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  1. Helmut Newtoni kuldpulmad

    Index Scriptorium Estoniae

    1999-01-01

    Saksa-juudi päritolu moefotograaf Helmut Newton tähistab 1999. aastal kolleegist abikaasa Alice Springsiga oma kuldpulma aastapäeva fotoalbumiga "Us and them", mis koondab Newtoni ja Springsi fotosid teineteisest, portreid, supermodelle ja mannekeene

  2. Hiigelraamat Helmut Newtonilt

    Index Scriptorium Estoniae

    1999-01-01

    Saksa kunstiraamatute kirjastaja Benedikt Taschen annab aastavahetuseks välja kirjastuse arvates suurima raamatu, mis XX sajandil avaldatud. Fotograaf Helmut Newtoni album 'Sumo' on 480 lk., autori poolt signeeritud, 50x70 cm, kaalub 30 kg, hind 22200 Eesti krooni. Aluse raamatule kujundab Philippe Starck

  3. (AJST) STRUCTURAL EVOLUTION OF BODE SAADU AREA ...

    African Journals Online (AJOL)

    opiyo

    2, pp. 17-24. STRUCTURAL EVOLUTION OF BODE SAADU AREA,. SOUTHWESTERN NIGERIA. C. T. Okonkwo. Department of Geology, University of Ilorin P.M.B. 1515, Ilorin, Nigeria. E-mail cokonkwo@unilorin.edu.ng. ABSTRACT: The Bode Saadu area comprises metasedimentary and metaigneous rocks which have.

  4. Emil Artin and Helmut Hasse the correspondence 1923-1958

    CERN Document Server

    Lemmermeyer, Franz; Roquette, Peter

    2014-01-01

    This volume presents English translations of the letters exchanged between Emil Artin and Helmut Hasse written from 1921 to 1958. The letters are accompanied by extensive comments explaining the mathematical background and providing other essential context. Most letters deal with class field theory and shed new light on the birth of one of its most profound results: Artin’s reciprocity law.

  5. Chasing Great Paths of Helmut “Oxidative Stress” Sies

    DEFF Research Database (Denmark)

    Majima, H.; Indo, H.; Nakanishi, I.

    2016-01-01

    Prof. Dr. Helmut Sies is a pioneer of “Oxidative Stress”, and has published over 18 papers with the name of “Oxidative Stress” in the title. He has been Editor-in-Chief of the journal “Archives of Biochemistry and Biophysics” for many years, and is a former Editor-in-Chief of the journal “Free...

  6. Female body as a fetish in Helmut Newton's photography

    Directory of Open Access Journals (Sweden)

    Pantović Katarina

    2017-01-01

    Full Text Available The paper illuminates some of the principles by which Helmut Newton's photographic poetics functions. It is examined from the perspectives of recent art history, feminist critique and psychoanalytic theory. His photographs came to a standstill not far from pornography, yet they stayed within the jet-set community, reflecting at the same time the sexual revolution in the 60s and 70s of the twentieth century and the rising of the fashion and film industries and other Western emancipatory movements. Newton's obscure photojournalism provoked conventions, presenting the female body as a fetish and object of erotic pleasure, affirming, nonetheless, a new feminine self-consciousness and freedom. Thus, he constituted modern eroticism by connecting fetishism, voyeurism and sadomasochism, creating a provocative hybrid photography that embraced fashion, eroticism and portrait, hence documenting, in highly stylistic manner, the decadency and eccentricity of the lifestyle of the rich.

  7. Modified BODE indexes: Agreement between multidimensional prognostic systems based on oxygen uptake

    Directory of Open Access Journals (Sweden)

    José Luis Lopez-Campos

    2010-05-01

    Full Text Available José Luis Lopez-Campos, Pilar Cejudo, Eduardo Marquez, Francisco Ortega, Esther Quintana, Carmen Carmona, Emilia BarrotUnidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospitales Universitarios Virgen del Rocío, Seville, SpainAim: It has been recently shown that the original BODE index has a high degree of correlation with two modified BODE indexes using maximal oxygen uptake expressed either as mL/min/kg (mBODE or as the percentage predicted (mBODE%. In this study we investigated the agreement between the two modified BODE indexes (mBODE and mBODE% in patients with stable chronic obstructive pulmonary disease (COPD.Methods: A total of 169 patients with stable COPD were enrolled in this cross-sectional study. Differences between the two mBODE indexes were assessed using kappa coefficients and Bland-Altman plots. One out of every three patients underwent the six-minute walking test to investigate the agreement with the original BODE index.Results: Correlations between the two mBODE indexes with each other (r = 0.96, P < 0.001 and with the original BODE index (mBODE r = 0.88, P < 0.001; mBODE% r = 0.93, P < 0.001 were excellent. However, the two mBODE indexes were significantly different from each other (mBODE 5.27 ± 2.3 versus mBODE% 4.31 ± 2.5; P < 0.001. The kappa coefficients were significantly lower (entire study group k = 0.5, P < 0.001 for every GOLD stage. The mean difference between the two mBODE indexes was 0.8 ± 0.6 units. Differences with the original BODE were higher for the mBODE (1.8 ± 0.9 than for the mBODE% (0.6 ± 0.8.Conclusions: The new mBODE indexes are highly correlated but significantly different from each other. The differences between the novel indexes deserve further scrutiny.Keywords: BODE index, chronic obstructive pulmonary disease, exercise testing, multidimensional evaluation, oxygen uptake

  8. Associations between BODE index and systemic inflammatory biomarkers in COPD.

    Science.gov (United States)

    Gaki, Eleni; Kontogianni, Konstantina; Papaioannou, Andriana I; Bakakos, Petros; Gourgoulianis, Konstantinos I; Kostikas, Konstantinos; Alchanatis, Manos; Papiris, Spyridon; Loukides, Stelios

    2011-12-01

    COPD is a multicomponent disease and systemic inflammation represents one of the possible mechanisms responsible for its systemic manifestations, including skeletal muscle weakness and cachexia. Fat-free mass index (FFMI) that reflects the skeletal muscle mass, has been shown to be associated with both dyspnoea and exercise capacity. We hypothesized that the multidimensional BODE index, that reflects the multicomponent nature of COPD, might be related to biomarkers of systemic inflammation. We further evaluated associations between FFMI and systemic inflammation. BODE index and FFMI were calculated in 222 stable COPD patients and 132 smokers or ex-smokers with normal lung function. Systemic inflammation was evaluated with the measurement of leptin, adiponectin, CRP, IL-6, and TNF-α in serum samples of COPD patients. In patients with COPD, both BODE index and FFMI presented significant positive and negative associations respectively with leptin levels (R(2) 0.61 and 0.65, respectively), whereas FFMI presented an additional negative association with the levels of TNF-α (R(2) 0.38). No significant associations were observed in smokers or ex-smokers with normal lung function. Both BODE index and FFMI, are related to the circulating levels of leptin in patients with COPD, suggesting a possible role for leptin in the systemic component of COPD. The additional association of FFMI with TNF-α may further support a role of systemic inflammation in muscle wasting in COPD.

  9. Laste väärkohtlemist tuleb ennetada / Bianca Mikovitsh ; interv. Helmut Bachmann

    Index Scriptorium Estoniae

    Mikovitsh, Bianca

    2006-01-01

    Eile algas Paides Kesk-Eesti noortekeskuses sotsiaaltöötajate kolmepäevane koolitus, mille eesmärk on tõkestada ja leevendada laste väärkohtlemist ja kuritarvitust Järvamaal. Kommenteerib Helmut Bachman, Kesk-Eesti noortekeskuse erinoorsootöö spetsialist

  10. Further numerical investigations into the significance of Bode's law.

    Science.gov (United States)

    Conway, B. A.; Zelenka, R. E.

    1988-01-01

    In this work the validity of the Titius-Bode law is assessed by comparing the closeness of fit of semi-random, computer-generated distance distributions to that of the actual distribution. The sample distributions are semi-random in that they are drawn from a population which obeys the "law of increasing differences", expressing the fact that the separations between planets increase, moving outward from the Sun. The authors consider the solar system excluding Pluto, whose orbit is very irregular, and two further abridged systems, lacking Mercury and/or Neptune. They also apply the analysis to the regular satellites of the giant planets. The results are not favourable to Bode's law.

  11. The Significance of BODE (BMI, Obstruction, Dyspnea, Exercise Index in Patients with Mustard Lung

    Directory of Open Access Journals (Sweden)

    OmidShadkam

    2013-05-01

    Full Text Available Introduction: Chronic Obstructive Pulmonary Disease (COPD secondary to sulfur mustard exposure, known as mustard lung, is an important late pulmonary complication. The BODE (Body mass index, Obstruction, Dyspnea, and Exercise index has been established as a valuable tool for determining the adverse consequences of COPD. The aim of this study was to evaluate the role of the BODE index in patients with mustard lung. Materials and Methods: Eighty-two consecutively stable patients with mustard lung with all levels of severity were entered this study. The following parameters were recorded in all patients: standard spirometry, pulse oximetry, health-related quality of life, the BODE index. Additionally, the severity of COPD was determined by GOLD (Global initiative for chronic Obstructive Lung Disease staging. The correlation of the BODE index with pulmonary parameters was determined. Results: The mean age of the patients was 47.30±7.08 SD years. The mean BODE index was 3.16±2.25 SD. There was a statistically significant inverse correlation between the BODE index and oxygen saturation (r=-0.30, p=0.007. Also a statistically significant correlation was found between the BODE index and quality of life (r=0.80, p=0.001. The BODE index was not correlated with age of the patients and duration of disease. Conclusions: The results of this study showed that the BODE index is correlated with important clinical parameters and can be used in clinical practice

  12. Obtaining real-time Bode (analysis of electronic circuits with LabVIEW

    Directory of Open Access Journals (Sweden)

    Akif Akgül

    2017-08-01

    Full Text Available Bode diagram is a term used in many fields of science and engineering that can be described as frequency response analysis. LabVIEW is a multifunctional program for acquiring, processing and analyzing data. In this paper, real time Bode diagram of electronic circuits are obtained in LabVIEW platform without using special VIs(virtual instruments such as SI Bode Plot VI. In addition to this, the realized study can be easily integrated in to other commonly used platforms such as MATLAB and C to obtain bode diagram results in real time. To evaluate performance of the realized study, Bode diagram results obtained from LabVIEW is compared with the results obtained from ORCAD-PSpice simulations.

  13. Behavior of Quality of Life (SGRQ) in COPD Patients According to BODE Scores.

    Science.gov (United States)

    Nonato, Nívia L; Díaz, Orlando; Nascimento, Oliver A; Dreyse, Jorge; Jardim, José R; Lisboa, Carmen

    2015-07-01

    To evaluate if the association between the BODE index and deterioration in health-related quality of life is linear. To determine possible associations between the BODE index and health status evaluated by the Saint George's Respiratory Questionnaire (SGRQ) at all levels of disease severity in COPD. A cross-sectional study was carried out on 253 patients from two Latin American respiratory centers (Brazil and Chile) with a clinical diagnosis of COPD, based on GOLD criteria. Assessment included the BODE index and the SGRQ questionnaire. Patients had a BODE index of 3.1±2.0; FEV1 (%) of 49±19.2; BMI (kg/m(2)) of 24.7±5.1; 6MWT distance (meters) of 444±96. Significant correlations were found between the BODE index and SGRQ total scores (r=0.5; <0.001), impact (r=0.45; <0.001) and activity (r=0.5; <0.001). From BODE score zero, HRQOL was already compromised in all SGRQ domains. SGRQ scores (total and domain) increased progressively for individual components of the BODE index, with the decrease in airflow limitation (<0.05), BMI (<0.002) and 6MWT (<0.05), and with the increase in the Modified Medical Research Council (MMRC) score (<0.05). There is an association between health-related quality of life, as assessed by the SGRQ and the BODE index within the entire spectrum of COPD severity. Even in early disease stages and BODE index zero, health-related quality of life is already impaired. Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

  14. The Titius-Bode law of planetary distances its history and theory

    CERN Document Server

    Nieto, Michael Martin

    1972-01-01

    The Titius-Bode Law of Planetary Distances: Its History and Theory is a 15-chapter book that first discusses the prehistory of the Law from Kepler to Kant. The next chapter details the formulation of the Titius-Bode Law. Subsequent chapters describe the Law's early successes and failures, early modifications of the Law, the Blagg-Richardson formulation, and the significance of the Law with respect to the origin of the solar system. Other chapters discuss the theories of all types that have been proposed to explain the """"classical Titius-Bode Law"""", i.e. the geometric progression.

  15. Analytic number theory in honor of Helmut Maier’s 60th birthday

    CERN Document Server

    Rassias, Michael

    2015-01-01

    This volume contains a collection of research and survey papers written by some of the most eminent mathematicians in the international community and is dedicated to Helmut Maier, whose own research has been groundbreaking and deeply influential to the field. Specific emphasis is given to topics regarding exponential and  trigonometric sums and their behavior in short intervals, anatomy of integers and cyclotomic polynomials, small gaps in sequences of sifted prime numbers, oscillation theorems for primes in arithmetic progressions, inequalities related to the distribution of primes in short intervals, the Möbius function, Euler’s totient function, the Riemann zeta function and the Riemann Hypothesis. Graduate students, research mathematicians, as well as computer scientists and engineers who are interested in pure and interdisciplinary research, will find this volume a useful resource. Contributors to this volume: Bill Allombert, Levent Alpoge, Nadine Amersi, Yuri Bilu, Régis de la Bretèche, Christian ...

  16. Hydrogen peroxide and central redox theory for aerobic life: A tribute to Helmut Sies: Scout, trailblazer, and redox pioneer.

    Science.gov (United States)

    Jones, Dean P

    2016-04-01

    When Rafael Radi and I wrote about Helmut Sies for the Redox Pioneer series, I was disappointed that the Editor restricted us to the use of "Pioneer" in the title. My view is that Helmut was always ahead of the pioneers: He was a scout discovering paths for exploration and a trailblazer developing strategies and methods for discovery. I have known him for nearly 40 years and greatly enjoyed his collegiality as well as brilliance in scientific scholarship. He made monumental contributions to 20th century physiological chemistry beginning with his first measurement of H2O2 in rat liver. While continuous H2O2 production is dogma today, the concept of H2O2 production in mammalian tissues was largely buried for half a century. He continued this leadership in research on oxidative stress, GSH, selenium, and singlet oxygen, during the timeframe when physiological chemistry and biochemistry transitioned to contemporary 21st century systems biology. His impact has been extensive in medical and health sciences, especially in nutrition, aging, toxicology and cancer. I briefly summarize my interactions with Helmut, stressing our work together on the redox code, a set of principles to link mitochondrial respiration, bioenergetics, H2O2 metabolism, redox signaling and redox proteomics into central redox theory. Copyright © 2015 The Author. Published by Elsevier Inc. All rights reserved.

  17. The relationship of the BODE index to oxygen saturation during daily activities in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Cutaia, Michael; Brehm, Robin; Cohen, Miriam

    2011-08-01

    The frequency of oxygen desaturation during daily activities in chronic obstructive pulmonary disease (COPD) is poorly defined. The BODE index predicts survival in COPD. The purpose of this study was to determine the relationship between BODE scores and oxygen saturation during daily activities. Seventy-eight patients with COPD (FEV(1) = 37%) underwent ambulatory oximetry and activity monitoring. We defined four activity categories: Walking, Slow-Intermittent-Walking (SIW), Active-Not-Walking (ANW), and Rest. We quantified oxygen desaturation during activity using a desaturation index (DSI = % time oxygen saturation SIW, 15% for ANW, and 28% for Rest. There was a strong association between BODE score and desaturation for Walking and SIW. During Walking, 21, 44, and 86% of patients in BODE groups I, II, and III, respectively, demonstrated desaturation. The DSI for Walking and SIW was increased in patients in BODE groups II and III compared to group I (P < 0.006, P < 0.007, respectively). BODE score was also linked to long-term oxygen therapy (LTOT) usage; the majority of patients not on LTOT (89%) had a BODE score <7. The majority of patients on LTOT (84%) demonstrated desaturation during Walking, but 42% of patients not on LTOT also demonstrated desaturation. In this subgroup of patients not on LTOT, all patients with a BODE score ≥ 7 demonstrated desaturation during Walking. The link between the BODE index and oxygen desaturation during daily activities suggests that desaturation is linked to disease severity. Our data suggest that patients with a BODE score ≥ 7 should be evaluated for desaturation during daily activities. Use of the BODE index to screen for exertional desaturation may have value as a tool that can lead to the earlier identification of patients who may be candidates for LTOT.

  18. Relationship of BODE Index to functional tests in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Eloisa Maria Gatti Regueiro

    2009-01-01

    Full Text Available OBJECTIVE: To determine if there is a correlation between the BODE Index and variables assessed during the Activities of Daily Living assessment, performance on lower limber tests, and peripheral muscle impairment of the upper limb in patients with chronic obstructive pulmonary disease. MATERIALS AND METHODS: Ten men (aged 58 to 80 years old with moderate to very severe obstruction were evaluated and classified by the BODE Index. They were evaluated by pulmonary ventilation (V•E, oxygen consumption (V•O2, and carbonic gas production (V•CO2 on the ADL assessment; Distance Walking (DW in the Six Minute Walking Test (6MWT and the Six Minute Walking Test on Treadmill (6MWTT; number of repetitions in the Sit-to-Stand Test; and the Hand Grip Strength Test. Correlations were evaluated between the classification and the tests performed (Pearson and Spearman test, p<0.05. RESULTS: The mean of the total score for the BODE Index was 2.80 (±1.03, with three patients scoring in the first quartile (Q1 and seven scoring in the second quartile (Q2. This Index showed a negative correlation with the 6MWTT (r=-0.86, the Sit-to-Stand Test (r=-0.66, and the Hand Grip Strength Test (r=-0.83. CONCLUSIONS: Our results show that there is no correlation between the BODE Index and the ventilatory and metabolic responses in the Activities of Daily Living assessment. On the other hand, a correlation was observed between the BODE Index and the variables assessed in the 6MWTT, Sit-to-Stand Test, and Hand Grip Strength Test in moderate to very severe Chronic Obstructive Pulmonary Disease patients. This suggests that these tests can be employed as predictors of physical exercise capacity, perhaps as complementary tests to the BODE Index.

  19. Education, Democracy, and Social Discourse: A Contemporary Response to George S. Counts and Boyd H. Bode

    Science.gov (United States)

    Collins, William J.

    2013-01-01

    Education, once known as the "great equalizer," is now being called to task for its tendency to disenfranchise and to legitimate inequality due to its obedience to the tenets of capitalism. Two of the nation's greatest educational thinkers, George S. Counts and Boyd H. Bode provided "instructions" for parents and teachers…

  20. Relationship between oxygen consumption kinetics and BODE Index in COPD patients

    Directory of Open Access Journals (Sweden)

    Borghi-Silva A

    2012-10-01

    Full Text Available Audrey Borghi-Silva,1 Thomas Beltrame,1,2 Michel Silva Reis,1 Luciana Maria Malosá Sampaio,3 Aparecida Maria Catai,1 Ross Arena,4 Dirceu Costa31Cardiopulmonary Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Federal University of São Carlos, São Carlos, SP, Brazil; 2Faculty of Applied Health Sciences, University of Waterloo, Waterloo, ON, Canada; 3Rehabilitation Sciences Master’s Program, Universidade Nove de Julho, Sao Paulo, SP, Brazil; 4Division of Physical Therapy, Department of Orthopedics, Division of Cardiology, Department of Internal Medicine, and Latin American and Iberian Institute, University of New Mexico, Albuquerque, NM, USABackground and objective: Patients with chronic obstructive pulmonary disease (COPD present with reduced exercise capacity due to impaired oxygen consumption (VO2, caused primarily by pulmonary dysfunction and deleterious peripheral adaptations. Assuming that COPD patients present with slower VO2 and heart rate (HR on-kinetics, we hypothesized that this finding is related to disease severity as measured by the BODE Index. In this context, the present study intends to evaluate the relationship between VO2 uptake on-kinetics during high-intensity exercise and the BODE Index in patients with COPD.Methods: Twenty males with moderate-to-severe stable COPD and 13 healthy control subjects matched by age and sex were evaluated. COPD patients were screened by the BODE Index and then underwent an incremental cardiopulmonary exercise test and a constant speed treadmill session at 70% of maximal intensity for 6 minutes. The onset of the exercise (first 360 seconds response for O2 uptake and HR was modeled according to a monoexponential fit.Results: Oxygen consumption and HR on-kinetics were slower in the COPD group compared with controls. Additionally, VO2 on-kinetic parameters revealed a strong positive correlation (r = 0.77, P < 0.05 with BODE scores and a moderate negative correlation with

  1. On 18 December 2004, the President of the Swiss Electro-technical Committee, Martin Reichle (left), presented the award to Helmut Schönbacher.

    CERN Multimedia

    2005-01-01

    Helmut Schönbacher, previously of CERN's Safety Commission, has received the 1906 Award of the International Electrotechnical Commission (IEC) for his standardization work on the influence of ionizing radiation on insulating materials. From 1986 until 2004, Schönbacher led a working group on radiation composed of internationally recognized experts, which edited standards in the IEC 60544 series on the determination of the effects of ionizing radiation on electrically insulating materials.

  2. Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index.

    Science.gov (United States)

    Puhan, Milo A; Garcia-Aymerich, Judith; Frey, Martin; ter Riet, Gerben; Antó, Josep M; Agustí, Alvar G; Gómez, Federico P; Rodríguez-Roisín, Roberto; Moons, Karel G M; Kessels, Alphons G; Held, Ulrike

    2009-08-29

    The BODE index (including body-mass index, airflow obstruction, dyspnoea, and exercise capacity) was an important contribution to the prognostic assessment of patients with chronic obstructive pulmonary disease (COPD). However, no study has assessed whether the risk of mortality predicted by the BODE index matches the observed mortality in different populations. We assessed the calibration of the BODE index, updated it to improve its calibration, and developed and validated a simplified index for use in primary-care settings. We included 232 patients from the Swiss Barmelweid cohort with longstanding and severe COPD and 342 patients from the Spanish Phenotype and Course of COPD cohort study who had had their first hospital admission due to moderate-to-severe COPD. In both cohorts we compared the observed 3-year risk of all-cause mortality with the risk predicted by the BODE index. We then updated the BODE index and developed a simplified ADO index (including age, dyspnoea, and airflow obstruction) from the Swiss cohort, and validated both in the Spanish cohort. Calibration of the BODE index was poor, with relative underprediction of 3-year risk of mortality by 36% in the Swiss cohort (median predicted risk 21.7% [IQR 12.7-31.7] vs 34.1% observed risk; p=0.013) and relative overprediction by 39% in the Spanish cohort (16.7% [12.7-31.7] vs 12.0%; p=0.035). The 3-year risk of mortality predicted by both the updated BODE (median 10.7% [8.1-13.8]) and ADO indices (11.8% [9.1-14.3]) matched the observed mortality in the Spanish cohort well (p=0.99 and p=0.98, respectively). Both the updated BODE and ADO indices could lend support to the prognostic assessment of patients with COPD in specialised and primary-care settings. Such assessment enhances the targeting of treatments to individual patients. Swiss National Science Foundation; Klinik Barmelweid; Fondo de Investigación Sanitaria Ministry of Health, Spain; Agència d'Avaluació de Tecnologia i Recerca M

  3. Validation of the i-BODE Index as a Predictor of hospitalization and Mortality in Patients with COPD Participating in Pulmonary Rehabilitation

    DEFF Research Database (Denmark)

    Moberg, Mia; Vestbo, Jørgen; Martinez, Gerd

    2014-01-01

    , and exercise capacity (ISWT) were significantly associated with all-cause mortality. The adjusted hazard ratio for death per one point increase in the i-BODE score was 1.28 (95% confidence interval 1.20 to 1.37). The i-BODE index was also a significant predictor of hospitalization, both for all causes and COPD...

  4. BODE index versus GOLD classification for explaining anxious and depressive symptoms in patients with COPD – a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Burghuber Otto

    2009-01-01

    Full Text Available Abstract Background Anxiety and depression are common and treatable risk factors for re-hospitalisation and death in patients with COPD. The degree of lung function impairment does not sufficiently explain anxiety and depression. The BODE index allows a functional classification of COPD beyond FEV1. The aim of this cross-sectional study was (1 to test whether the BODE index is superior to the GOLD classification for explaining anxious and depressive symptoms; and (2 to assess which components of the BODE index are associated with these psychological aspects of COPD. Methods COPD was classified according to the GOLD stages based on FEV1%predicted in 122 stable patients with COPD. An additional four stage classification was constructed based on the quartiles of the BODE index. The hospital anxiety and depression scale was used to assess anxious and depressive symptoms. Results The overall prevalence of anxious and depressive symptoms was 49% and 52%, respectively. The prevalence of anxious symptoms increased with increasing BODE stages but not with increasing GOLD stages. The prevalence of depressive symptoms increased with both increasing GOLD and BODE stages. The BODE index was superior to FEV1%predicted for explaining anxious and depressive symptoms. Anxious symptoms were explained by dyspnoea. Depressive symptoms were explained by both dyspnoea and reduced exercise capacity. Conclusion The BODE index is superior to the GOLD classification for explaining anxious and depressive symptoms in COPD patients. These psychological consequences of the disease may play a role in future classification systems of COPD.

  5. Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease : the updated BODE index and the ADO index

    NARCIS (Netherlands)

    Puhan, Milo A.; Garcia-Aymerich, Judith; Frey, Martin; ter Riet, Gerben; Anto, Josep M.; Agusti, Alvar G.; Gomez, Federico P.; Rodriguez-Roisin, Roberto; Moons, Karel G. M.; Kessels, Alphons G.; Held, Ulrike

    2009-01-01

    Background The BODE index (including body-mass index, airflow obstruction, dyspnoea, and exercise capacity) was an important contribution to the prognostic assessment of patients with chronic obstructive pulmonary disease (COPD). However, no study has assessed whether the risk of mortality predicted

  6. Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index

    NARCIS (Netherlands)

    Puhan, Milo A.; Garcia-Aymerich, Judith; Frey, Martin; ter Riet, Gerben; Antó, Josep M.; Agustí, Alvar G.; Gómez, Federico P.; Rodríguez-Roisín, Roberto; Moons, Karel G. M.; Kessels, Alphons G.; Held, Ulrike

    2009-01-01

    Background The BODE index (including body-mass index, airflow obstruction, dyspnoea, and exercise capacity) was an important contribution to the prognostic assessment of patients with chronic obstructive pulmonary disease (COPD). However, no study has assessed whether the risk of mortality predicted

  7. Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD

    DEFF Research Database (Denmark)

    Al-shair, Khaled; Dockry, Rachel; Mallia-Milanes, Brendan

    2009-01-01

    BACKGROUND: The prevalence of depression in stable COPD patients varies markedly, possibly because of use of different scales. We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle...... wasting in clinically stable COPD patients. METHODS: 122 stable COPD patients were assessed with the Centre for Epidemiologic Studies Depression Scale (CES-D) and the Brief Assessment Schedule Depression Cards (BASDEC). We also assessed patients with spirometry, bioelectrical impedance analysis, 6-minute...... walk distance (6MWD), St George's Respiratory Questionnaire (SGRQ) and MRC dyspnoea and Borg scales. RESULTS: The CES-D and BASDEC scales detected almost similar prevalence rates of depression (21% vs 17%) with a Kappa coefficient of 0.68, pdepression in women...

  8. BODE INDEX AND THE RISK OF OSTEOPOROTIC FRACTURES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

    Directory of Open Access Journals (Sweden)

    E. V. Kochetova

    2016-01-01

    Full Text Available The goal of the study: to define theoretic correlation between BODE index in men with chronic obstructive pulmonary disease (COPD and risk of osteoporotic fractures assessed as per bone mineral density and FRAX integral rate.Materials and methods. 125 men suffering from COPD smoking for a long period of time (the smoker index of 240 and time of smoking (packs/years of 40 were included into the study. 10 year risk of osteoporotic fractures was assessed by FRAX software. The respiratory function was evaluated by the multi-module unit of MasterLab/Jaeger type. BODE index was defined in the patients.Results. The minimum level of BODE was observed in those suffering from COPD of the 2nd stage – 2.23 ± 0.88. In case of the 3rd stage of COPD BODE made 5.05 ± 1.19, in the 4th stage of COPD it made 7.0 ± 1.0. The maximum risk of fractures was detected in the patients of the 4th stage of COPD. The minimum risk of fractures was diagnosed in the patients of the 2nd stage of COPD. The confident correlations were found between BODE and bone mineral density (r = -0.71, p < 0.005, as well as confident correlations between BODE and the risk of fractures (r = -0.54, p < 0.05. Conclusions. The correlation has been found between BODE index and the risk of fractures. 

  9. Evaluating a 1D and 2D water quality modeling framework: A case study of the lower Bode River, Germany

    Science.gov (United States)

    Sinha, Sumit; Rode, Michael; Borchardt, Dietrich

    2014-05-01

    The Bode River catchment in the Harz Mountain area of central Germany is heavily influenced by anthropogenic factors. 70% of the catchment is dominated by agriculture, 23 % by forest and the rest 7% is urban in nature. The area of the catchment is approximately 3300 km2 and is characterized by sharp gradients in temperature, precipitation and land use. In order to acquire better understanding of the hydrological nature of the catchment and biogeochemical characteristics of the Bode River various monitoring stations have been deployed as a part of the larger earth observation network initiative named Terrestrial Environmental Observatories. One of the major issues with the catchment is the problem of eutrophication due to solute inputs from agriculture. The research presented here evaluated the application and development of 1D and 2D hydrodynamic and water quality models in the downstream area of the Bode River. A stretch of 30 kms between Hadmersleeben and Stassfurt in the downstream area of the Bode River was modeled using 1D model HEC-RAS, the focus of the water quality modeling was transport and uptake of nitrate in the aforementioned modeled stretch. Flood events of varying peak magnitude at different times of the year were modeled. As regards to 2D modeling, TELEMAC-2D model was applied for the same reach. The hydrodynamic simulation results were validated with the help of free surface elevation at Athensleben, 8 kms upstream from the downstream end at Stassfurt. Water quality modeling, focusing on the Nitrate removal for the aforementioned stretch, is applied and developed for both 1D and 2D modeling framework. Results from hydrodynamic and water quality modeling were validated with RMSE (Root Mean Square Error) value of 0.074 and 0.36 for the modeled state variables across various events simulated. For the nutrient-rich reach modeled in this research it was found that the nutrient removal capacity of the stream is directly proportional to the incoming

  10. Does the BODE index reflect the level of physical activity in daily life in patients with COPD?

    Science.gov (United States)

    Mantoani, Leandro C; Hernandes, Nídia A; Guimarães, Mônica M; Vitorasso, Renato L; Probst, Vanessa S; Pitta, Fábio

    2011-01-01

    To study the relationship between the level of physical activity in daily life and disease severity assessed by the BODE index in patients with chronic obstructive pulmonary disease (COPD). Sixty-seven patients with COPD (36 men) with forced expiratory volume in the first second (FEV(1)) of 39 (27-47)% predicted and age of 66 (61-72) years old were evaluated by spirometry, dyspnea levels (measured by the Medical Research Council scale, MRC) and by the 6-minute walking test (6MWT). The BODE index was calculated based on the body mass index (weight/height²), FEV(1), MRC and 6MWT, and then the patients were divided in four quartiles according to their scores (Quartile I: 0 to 2 points, n=15; Quartile II: 3 to 4 points, n=20; Quartile III: 5 to 6 points, n=23; Quartile IV: 7 to 10 points, n=9). Two activity monitors (DynaPort® and SenseWear®) were used to evaluate the level of physical activity in daily life. The Kruskal-Wallis test (Dunns's post-hoc test), the Mann-Whitney test and the Spearman Correlation Coefficient were used for statistical analysis. There were modest correlation between the BODE index and the time spent walking per day, the total daily energy expenditure and the time spent in moderate and vigorous activities per day (-0.32 ≤ r ≤ -0.47; p≤0.01 for all variables). When comparing the pooled quartiles I+II with III+IV, there were significant difference between the time spent walking per day, the total daily energy expenditure and the time spent in moderate activities per day (p≤0.05). The level of physical activity in daily life has a modest correlation with the classification of COPD severity assessed by the BODE index, reflecting only differences between patients with classified as mild-moderate and severe-very severe COPD.

  11. Regional nitrogen dynamics in the TERENO Bode River catchment, Germany, as constrained by stable isotope patterns.

    Science.gov (United States)

    Mueller, Christin; Krieg, Ronald; Merz, Ralf; Knöller, Kay

    2016-01-01

    Interactions between hydrological characteristics and microbial activities affect the isotopic composition of dissolved nitrate in surface water. Nitrogen and oxygen isotopic signatures of riverine nitrate in 133 sampling locations distributed over the Bode River catchment in the Harz Mountains, Germany, were used to identify nitrate sources and transformation processes. An annual monitoring programme consisting of seasonal sampling campaigns in spring, summer and autumn was conducted. δ(15)N and δ(18)O of nitrate and corresponding concentrations were measured as well as δ(2)H and δ(18)O of water to determine the deuterium excess. In addition, precipitation on 25 sampling stations was sampled and considered as a potential input factor. The Bode River catchment is strongly influenced by agricultural land use which is about 70 % of the overall size of the catchment. Different nitrogen sources such as ammonia (NH4) fertilizer, soil nitrogen, organic fertilizer or nitrate in precipitation show partly clear nitrate isotopic differences. Processes such as microbial denitrification result in fractionation and lead to an increase in δ(15)N of nitrate. We observed an evident regional and partly temporal variation of nitrate isotope signatures which are clearly different between main landscape types. Spring water sections within the high mountains contain nitrate in low concentrations with low δ(15)NNO3 values of -3 ‰ and high δ(18)ONO3 values up to 13 ‰. High mountain stream water sub-catchments dominated by nearly undisturbed forest and grassland contribute nitrate with δ(15)NNO3 and δ(18)ONO3 values of -1 and -3.5 ‰, respectively. In the further flow path, which is affected by an increasing agricultural land use and urban sewage, we recognized an increase in δ(15)NNO3 and δ(18)ONO3 up to 22 and 18 ‰, respectively, with high variations during the year. A correlation seems to exist between the percentage of agricultural land use area and the

  12. The effects of acupoint-catgut embedment combined with medical treatment on the BODE index scores of chronic obstructive pulmonary disease (COPD) patients

    Science.gov (United States)

    Giri, P. B. S. W.; Srilestari, A.; Abdurrohim, K.; Yunus, F.

    2017-08-01

    Chronic Obstructive Pulmonary Disease (COPD) is now the fourth leading cause of death in the world. As COPD medications are associated with high mortality levels, continuous research into the improvement of treatment modalities is being conducted. This study aimed to identify the effects of acupoint-catgut embedment combined with medical treatment on the Body mass index, airflow Obstruction, Dyspnea and Exercise capacity (BODE) index scores of COPD patients. A single-blind randomized controlled trial was conducted on 48 patients; participants were allocated into either the acupoint-catgut embedment with medication group (case group) or the sham acupuncture with medication group (control group). Acupoint-catgut embedment was conducted at the BL13 Feishu, BL43 Gaohuangshu, BL20 Pishu, BL23 Shenshu, and ST40 Fenglong points two times at an interval of 15 days. The BODE index, a primary outcome indicator, was assessed on Day 1 and Day 30. The results showed statistically and clinically significant differences between the two groups—in fact, BODE index scores were reduced by 1.83 points in the case group (p = 0.000). Ultimately, BODE index scores were lower in the intervention group than in the control group, thus indicating a statistically significant and clinically important improvement of COPD-related symptoms. According to these results, acupoint-catgut embedment combined with medical treatment is concluded to be more effective than medical treatment alone in reducing BODE index scores.

  13. Correspondents and the Cold War. How foreign correspondents acted during the chancellery of Helmut Schmidt (1974-1982 in Germany and abroad

    Directory of Open Access Journals (Sweden)

    Thomas Birkner

    2016-09-01

    Full Text Available This paper addresses the role of foreign correspondents during the Cold War. More specifically, it focuses on the case study of the relationship between former German Chancellor Helmut Schmidt and foreign correspondents in Germanyand abroad. A synthesis of historical research and qualitative analysis of documentsand interviews provides a behind-the-scenes look at media diplomacy during the 70s andearly 80s. From the perspective of system theory and the concept of mediatization, mediaand politics are understood as separate but equal social systems that interact with eachother. This case study is based on documents from the private archives of Helmut Schmidtand from the annals of his party, the German Social Democrats, as well as interviews conducted with Schmidt and former journalist and correspondent Gerd Ruge. Analysis of theinterviews and the private and secret correspondence of Schmidt with journalists affordsan inside view into the role foreign correspondents played during the Cold War when communicationacross the Iron Curtain was especially challenging. Our conclusions show howimportant foreign correspondents are in international relations, while also demonstrating that aspects of international diplomacy, though involving journalists, were not necessarily included in media coverage. This study helps to clarify the complex interactions between media and politics. On the basis of our explorative research, a model is proffered of possible relations and interactions between politicians and foreign correspondents. As sources of information and means of communication, foreign correspondents exert a strong influence on the fates of nations and governments, before and behind the scenes. Esta proposta aborda o papel dos correspondentes estrangeiros durante a Guerra Fria. Mais especificamente, centra-se no estudo de caso da relação entre o ex-chanceler alemão Helmut Schmidt e os correspondentes estrangeiros na Alemanha e no exterior. A s

  14. A physical interpretation of the Titius-Bode rule and its connection to the closed orbits of Bertrandʼs theorem

    Science.gov (United States)

    Christodoulou, Dimitris M.; Kazanas, Demosthenes

    2017-12-01

    We consider the geometric Titius-Bode rule for the semimajor axes of planetary orbits. We derive an equivalent rule for the midpoints of the segments between consecutive orbits along the radial direction and we interpret it physically in terms of the work done in the gravitational field of the Sun by particles whose orbits are perturbed around each planetary orbit. On such energetic grounds, it is not surprising that some exoplanets in multiple-planet extrasolar systems obey the same relation. However, it is surprising that this simple interpretation of the Titius-Bode rule also reveals new properties of the bound closed orbits predicted by Bertrand’s theorem, which has been known since 1873.

  15. Field data-based mathematical modeling by Bode equations and vector fitting algorithm for renewable energy applications.

    Science.gov (United States)

    Sabry, A H; W Hasan, W Z; Ab Kadir, M Z A; Radzi, M A M; Shafie, S

    2018-01-01

    The power system always has several variations in its profile due to random load changes or environmental effects such as device switching effects when generating further transients. Thus, an accurate mathematical model is important because most system parameters vary with time. Curve modeling of power generation is a significant tool for evaluating system performance, monitoring and forecasting. Several numerical techniques compete to fit the curves of empirical data such as wind, solar, and demand power rates. This paper proposes a new modified methodology presented as a parametric technique to determine the system's modeling equations based on the Bode plot equations and the vector fitting (VF) algorithm by fitting the experimental data points. The modification is derived from the familiar VF algorithm as a robust numerical method. This development increases the application range of the VF algorithm for modeling not only in the frequency domain but also for all power curves. Four case studies are addressed and compared with several common methods. From the minimal RMSE, the results show clear improvements in data fitting over other methods. The most powerful features of this method is the ability to model irregular or randomly shaped data and to be applied to any algorithms that estimating models using frequency-domain data to provide state-space or transfer function for the model.

  16. Field data-based mathematical modeling by Bode equations and vector fitting algorithm for renewable energy applications

    Science.gov (United States)

    W. Hasan, W. Z.

    2018-01-01

    The power system always has several variations in its profile due to random load changes or environmental effects such as device switching effects when generating further transients. Thus, an accurate mathematical model is important because most system parameters vary with time. Curve modeling of power generation is a significant tool for evaluating system performance, monitoring and forecasting. Several numerical techniques compete to fit the curves of empirical data such as wind, solar, and demand power rates. This paper proposes a new modified methodology presented as a parametric technique to determine the system’s modeling equations based on the Bode plot equations and the vector fitting (VF) algorithm by fitting the experimental data points. The modification is derived from the familiar VF algorithm as a robust numerical method. This development increases the application range of the VF algorithm for modeling not only in the frequency domain but also for all power curves. Four case studies are addressed and compared with several common methods. From the minimal RMSE, the results show clear improvements in data fitting over other methods. The most powerful features of this method is the ability to model irregular or randomly shaped data and to be applied to any algorithms that estimating models using frequency-domain data to provide state-space or transfer function for the model. PMID:29351554

  17. Field data-based mathematical modeling by Bode equations and vector fitting algorithm for renewable energy applications.

    Directory of Open Access Journals (Sweden)

    A H Sabry

    Full Text Available The power system always has several variations in its profile due to random load changes or environmental effects such as device switching effects when generating further transients. Thus, an accurate mathematical model is important because most system parameters vary with time. Curve modeling of power generation is a significant tool for evaluating system performance, monitoring and forecasting. Several numerical techniques compete to fit the curves of empirical data such as wind, solar, and demand power rates. This paper proposes a new modified methodology presented as a parametric technique to determine the system's modeling equations based on the Bode plot equations and the vector fitting (VF algorithm by fitting the experimental data points. The modification is derived from the familiar VF algorithm as a robust numerical method. This development increases the application range of the VF algorithm for modeling not only in the frequency domain but also for all power curves. Four case studies are addressed and compared with several common methods. From the minimal RMSE, the results show clear improvements in data fitting over other methods. The most powerful features of this method is the ability to model irregular or randomly shaped data and to be applied to any algorithms that estimating models using frequency-domain data to provide state-space or transfer function for the model.

  18. Titius-Bode law in the Solar System. Dependence of the regularity parameter on the central body mass

    Science.gov (United States)

    Georgiev, Tsvetan B.

    2016-07-01

    Near-commensurability of the orbital sizes or periods exists in the Solar system for the massive planets and the massive satellites of Jupiter, Saturn and Uranus. It is well revealed by the Titius-Bode law (TBL) long ago by Dermott (1968), but is not been explained convincingly yet. Independently on this fact, the question about the dependence of the scale constant of the TBL on the mass of the central body is open. In this paper we show such a dependence. Due to the dynamic evolution the orbits of the massive planets and satellites may be in a transient stage when a primary TBL is well pronounced. Simultaneously a secondary TBL, a trail from the past as a hint for the future, may be less pronounced. The TBL is fitted after the numeration of the objects. For this reason we derive a special "curve" and we use 2 its minimums to introduce a primary and a secondary numeration for the objects. Thus we derive constants of 2 TBLs and build the searched dependence by twice as many points. In this paper we show and use pairs of TBLs for the satellite systems of Jupiter, Saturn, Uranus, Neptune and Pluto, as well as for the solar system in two cases - with 4 massive planets and with 8 massive planets. In fig. 10 we show the statistically significant dependences where the coefficient of the near-commensurability for the orbital sizes varies from about 1.3 for the satellites of Pluto to about 1.7 for the planets of the Sun.

  19. 32nd Annual Conference of the Gesellschaft für Klassifikation e.V., Joint Conference with the British Classification Society (BCS) and the Dutch/Flemish Classification Society (VOC), Helmut-Schmidt-University

    CERN Document Server

    Lausen, Berthold; Seidel, Wilfried; Ultsch, Alfred

    2010-01-01

    Data Analysis, Data Handling and Business Intelligence are research areas at the intersection of computer science, artificial intelligence, mathematics, and statistics. They cover general methods and techniques that can be applied to a vast set of applications such as in marketing, finance, economics, engineering, linguistics, archaeology, musicology, medical science, and biology. This volume contains the revised versions of selected papers presented during the 32nd Annual Conference of the German Classification Society (Gesellschaft für Klassifikation, GfKl). The conference, which was organized in cooperation with the British Classification Society (BCS) and the Dutch/Flemish Classification Society (VOC), was hosted by Helmut-Schmidt-University, Hamburg, Germany, in July 2008.

  20. Boscovich force in spherical coordinates: some gravitational implications for deflection of light, Trojan orbits, Titius-Bode structures, ring structures and flat rotation rate of galaxies

    Science.gov (United States)

    Munera, Hector A.

    2015-08-01

    From philosophical considerations, Boscovich proposed around 1760 a unified force of nature. Boscovich’s force turns out to be a particular case of the novel solutions for the homogeneous wave equation in spherical coordinates found by the present author in the 1990s [Found. Phys. Lett. 10, 31-41 (1997)]. As noted by J. J. Thomson before Bohr’s quantum theory, Boscovich’s force exhibits quantization in energy and distance.For each quantum number, our non-harmonic functions of the first kind (NHF-1k) predict the existence of a discrete number of spherical surfaces in dynamical equilibrium (SSDE), leading to both Titius-Bode and ring structures. Predictions agree with observed Titius-Bode patterns in our planetary system, and in the moons of Mars, Jupiter, Uranus, Saturn, and Neptune. At distances beyond the quantum structure associated with SSDEs, for even NHF-1ks the force becomes Newton’s inverse-square law; however, odd NHF-1ks exhibit a non-zero limit as distance tends to infinity, which immediately explains the flat rotation rate of spiral galaxies without additional asumptions as dark matter or MOND models. The SSDEs provide the physical counterpart to the mathematical spheres that appear in the recent solution of the three-body problem and the orbits of Trojan moons [Suvakov & Dmitrasinovic, Phys. Rev. Lett. 110, 114301 (2013)]. The inner-most SSDE is a photon-sphere, but inside it there is a monotonously increasing repulsion, thus acting as a “white” hole; this could be relevant in the context of the contradictory appearance of a black and a white hole in the creation of black holes in the laboratory [Leonhard & Philbin ArXiv:0803.0669 5 March 2008]. Deflection of light does not occur at the SSDEs but at intermediate locations where gravitational attraction reaches a maximum. Calculation of deflection involves three non-Newtonian aspects: the force is not exactly Newton’s, the distance is larger than the radius of the physical surface, and

  1. IL-8 gene variants are associated with lung function decline and multidimensional BODE index in COPD patients but not with disease susceptibility: a validation study.

    Science.gov (United States)

    Córdoba-Lanús, Elizabeth; Baz-Dávila, Rebeca; Espinoza-Jiménez, Adriana; Rodríguez-Pérez, María C; Varo, Nerea; de-Torres, Juan P; González-Almeida, Delia; Aguirre-Jaime, Armando; Casanova, Ciro

    2015-02-01

    COPD is a leading cause of dead worldwide and tobacco smoking is its major risk factor. IL8 is a proinflammatory chemokine mainly involved in the acute inflammatory reaction. The aim of this study was to test the association of IL-8, CXCR1 and CXCR2 gene variants and COPD susceptibility as part of a replication study and explore the effect of these variations in disease progression. 9 tagSNPs were genotyped in 728 Caucasian individuals (196 COPD patients, 80 smokers and 452 non-smoking controls). Pulmonary compromise was evaluated using spirometry and clinical parameters at baseline and annually over a 2 years period. We also determined plasma levels of TNF-α, IL-6, IL-8 and IL-16 in COPD patients. There was a lack of association between gene variants or haplotypes with predisposition to COPD. No correlation was observed between the polymorphisms and cytokines levels. Interestingly, significant associations were found between carriers of the rs4073A (OR = 3.53, CI 1.34-9.35, p = 0.01), rs2227306C (OR = 5.65, CI 1.75-18.88, p = 0.004) and rs2227307T (OR = 4.52, CI = 1.49-12.82, p = 0.007) alleles in the IL-8 gene and patients who scored higher in the BODE index and showed an important decrease in their FEV1 and FVC during the 2 years follow-up period (p disease, with an affectation beyond the pulmonary function and importantly, a reduction in lung function along the follow-up years.

  2. Ikka PÖFFist, 13. korda / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    2009-01-01

    13. Pimedate Ööde Filmifestival Tallinnas. Võistlusfilmid: "Minu aasta ilma seksita" (Austraalia; režissöör Sarah Watt), "Laila sünnipäev" (Palestiina-Tuneesia-Holland; režissöör Rashid Masharawi), "Emma Blanki viimased päevad" (Holland; režissöör Alex van Warmerdam), "Sinihabe" (Prantsusmaa; režissöör Catherine Breillat)

  3. Puhu ristist maailma teedele / Helmut Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Helmut, 1930-

    2009-01-01

    Tutvustus: Varje dag...-sextio år av lycka. Till minnet av Aare R. Mörner (1926-2008). Utgivare: Magnus och Henrik Mörner. Printed in Hungary, 2008. /Tõlge/: Iga päev...- kuuskümmend aastat õnne. Aare-R. Mörneri (1926-2008) mälestuseks. Väljaandjad: Magnus ja Henrik Mörner. Trükitud Ungaris, 2008. 199 lk.

  4. Rahvavalgustajad, teadlased, kirjanikud... / Helmut Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Helmut, 1930-

    1980-01-01

    Tartu Ülikooli ajaloost. Naabermaade kultuuriloosse oma tegevusega jälgi jätnud TÜ kasvandikest Georg Manzel (Mancelius), Christian Fürecker, Janis Reiters (Johannes Reuter), Olof (Olaus) Verelius, Isak Börk (Björk), Johannes Terserus, Abraham Thauvonius, Arvid Moller ja Petrus Schomerus

  5. Helmut Duidecka", Jadwiga Frelekb, Wojciech J. Szczepekb and

    African Journals Online (AJOL)

    oonfiguration (2,3). Moreover, in the E—configuration. (3-8 should suffer a 1-2 ppm shielding whereas its signal shift should be very similar to that of the ketone if the hydroxyl group is in Zeoirientation. A - C signal assignment of steroids can be ...

  6. Uso de testes complementares para avaliação do congelamento do sêmen de bodes submetidos ao manejo de fotoperíodo artificial Use of complementary tests to evaluate the freezing ability of semen from goats under artificial photoperiod exposure

    Directory of Open Access Journals (Sweden)

    Anselmo Domingos Ferreira Santos

    2006-10-01

    Full Text Available O congelamento do sêmen de bodes das raças Alpina e Saanen submetidos ao manejo de fotoperíodo artificial foi avaliado por meio dos testes de termorresistência (TTR, hiposmótico (HOST e de integridade do acrossoma. Foram utilizados oito machos caprinos (quatro da raça Alpina e quatro da raça Saanen de duas idades diferentes (jovens e adultos. A qualidade do sêmen durante as etapas do congelamento foi superior em bodes jovens de ambas as raças. Avaliada pelo TTR, a motilidade do sêmen fresco apresentou longevidade pós-descongelamento. Os resultados de motilidade espermática, obtidos imediatamente após o descongelamento, tiveram reflexos positivos sobre o TTR, indicando que os sêmens que apresentaram maior motilidade pós-coleta (86,2% vs 79,3% e pós-descongelamento (37,7% vs 32,0% tiveram maior longevidade seminal. Os resultados do HOST, tanto para o sêmen fresco quanto para o congelado, não diferiram entre raças e idades. Houve redução na porcentagem de espermatozóides íntegros após o congelamento e descongelamento do sêmen dos animais da raça Alpina e dos adultos Saanen. Houve redução superior a 14% nos valores do HOST para o sêmen congelado em relação aos valores observados para o sêmen fresco (38,0 vs 52,0%, respectivamente. A motilidade espermática progressiva mostrou maior sensibilidade à criopreservação que a integridade da membrana espermática, indicando que a motilidade espermática é mais afetada pelo processo de congelamento que a membrana plasmática. A integridade do acrossoma não foi influenciada pelo descongelamento. Os índices de danos acrossomais (edema, desprendimento parcial e até perda total de acrossoma mostraram-se dentro do padrão aceitável (44,5%, tanto no pós-descongelamento como após o término do TTR.The freezing ability of semen from Alpine and Saanen goats submitted to an artificial photoperiod exposure were evaluated by the thermo-resistance (TTR and hypoosmotic (HOST tests

  7. Childhood dilated cardiomyopathy in Jos, Nigeria | Bode-Thomas ...

    African Journals Online (AJOL)

    Results: childhood DCM (6 cases) was the commonest acquired heart condition diagnosed in children under the age of 5 years. Four patients presented with recurrent episodes of congestive heart failure (CHF) while 2 presented during their first episode. DCM was initially considered in only 1 child. Another child suffered a ...

  8. Computer in surgery | Bode | Nigerian Journal of Surgical Research

    African Journals Online (AJOL)

    Like most truly epochal revolutions, the computer age crept in on this generation before we could figure out its numerous possible applications. Over the past few years, an increasing appreciation of the usefulness of digital technology has emerged among various professions. How has the advent of the computer impacted ...

  9. Cardiac Arrhythmias in Children with Sickle Cell Anaemia | Bode ...

    African Journals Online (AJOL)

    Background : Sickle cell anaemia (SCA) is an important cause of morbidity and mortality in tropical Africa. Recurrent episodes of vaso-occlusive crisis often lead to organ ischaemia and/or infarction. Arrythmias are common and reliable manifestations of myocardial ischaemia and often follow infarction. The prevalence and ...

  10. FRACTAL MODEL OF DAMAGE ACCUMULATION IN SOLID BODES

    Directory of Open Access Journals (Sweden)

    Alim. Abed Al-Zobaede

    2014-01-01

    Full Text Available The paper considers a model of damage accumulation in parts of machines and structures which is based on a theory of fractals. Hidden process of destruction prior to the formation of macroscopic cracks is usually associated with the accumulation of micro-damages. Various models of damage accumulation and crack growth under the influence of power and thermal loads. However, models describing the accumulation process of micro-damages and their outgrowth into macro-crack are practically non-existent. Fractal structures with self-similarity are an adequate model of the fracture process. The MacDonald correlation function describing the medium structure allows to present the self-similarity of structures within a certain range of scales.The paper reviews models of damage accumulation near an opening in a composite medium and at layer boundaries. The Cantor model in a forward algorithm and a backward algorithm have been used in order to describe the model of damage accumulation. As it is known, the Cantor fractal (Cantor dust is obtained by using a recursive algorithm being applied to fracture mechanics can be regarded as a model of stepwise formation of dispersed micro-damages. The process of damage accumulation (latent destruction phase and its transition in the formation process of macro-cracks and their unification in a through-thickness crack can be described, for example, by the Paris' law.

  11. Sister Mary Joseph nodule: it does not bode well

    Directory of Open Access Journals (Sweden)

    Stephen A. Geller

    2014-09-01

    Full Text Available Sister Mary Joseph, the superintendent nurse and surgical assistant of Dr. William Mayo at St Mary’s Hospital (presently Mayo Clinic, was the first to note the association of umbilical nodules with intra-abdominal malignancy. Dr. Hamilton Bailey, a British surgeon, in his classic book Physical Signs in Clinical Surgery named the lesion for Sister Mary Joseph; the palpable bulging usually firm nodule distorting and invading into the umbilicus as a manifestation of metastatic malignancy from the abdomen or the pelvis.

  12. Concentrações plasmáticas de testosterona, triiodotironina (T3 e tiroxina (T4 em bodes submetidos ao estresse calórico Plasma concentrations of testosterone, triiodothyronine (T3, and thyroxine (T4 in bucks submitted to heat stress

    Directory of Open Access Journals (Sweden)

    L.A. Coelho

    2008-12-01

    Full Text Available Para verificar o efeito do estresse calórico (EC nas concentrações plasmáticas de testosterona, triiodotironina (T3 e tiroxina (T4, oito bodes, das raças Saanen (n=4 e Alpina (n=4, foram mantidos em câmara bioclimática, sob condições de termoneutralidade (13,0ºC a 26,7ºC durante 30 dias e, após um período (60 dias de descanso, submetidos ao EC (23,7ºC a 34,0ºC por 30 dias. Para minimizar as variações sazonais nos perfis hormonais devido ao fotoperíodo, durante toda fase experimental, incluindo a de adaptação em condições de termoneutralidade (30 dias, o fotoperíodo foi controlado utilizando-se alternância de dias longos (16h de luz e 8h de escuro e de dias curtos (8h de luz e 16h de escuro a cada 30 dias. As amostras de sangue foram coletadas duas vezes por semana durante cinco semanas. No conjunto das raças, o EC não influenciou (P>0,05 as concentrações de testosterona (1,8±0,2 vs 1,3±0,2ng/ml e nem a de T4 (52,7±2,8 vs 50,0±2,8ng/ml. Houve declínio (PTo verify the effect of heat stress (HS on plasma testosterone, triiodothyronine (T3, and thyroxine (T4 concentrations, eight Saanen (n=4 and Alpine Brown (n=4 bucks were kept in climate chamber under thermal neutral conditions (13.0ºC to 26.7ºC for 30 days. After a resting period (60 days, the same bucks were submitted to heat stress (23.7ºC to 34.0ºC for another 30 days. To neutralize the seasonal variations of hormonal profiles throughout the period, the photoperiod was controlled every 30 days altering long (16 hours of light and 8 hours of darkness and short days (8 hours of light and 16 hours of darkness. The blood samples were collected twice a week during five weeks. In both breeds, there was no effect of HS (P>0.05 on plasma concentrations of testosterone (1.8±0.2 vs 1.3±0.2ng/ml and T4 (52.7±2.8 vs 50.0±2.8ng/ml. There was a decline (P<0.01 of plasma T3 concentrations (1.3±0.1 vs 1.0±0.1ng/ml after HS treatment, but this reduction was only

  13. Punase režissööri tummad tunnistajad / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    1998-01-01

    Saksa režissöör Georg Wilhelm Pabst (1885-1967) ja saksa filminädalal Tallinna Kinomajas näidatud G. W. Pabsti filmid "Rõõmutu kõrvaltänav" ("Die freundlose Gasse") ja "Pandora laegas" ("Die Büchse der Pandora")

  14. Viis filmiõhtut PÖFFi seltsis / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    2008-01-01

    Pimeda Ööde Filmifestivali eel spetsiaalselt Stiili lugejaile mõeldud soovitus : režissöör Anne Fontaine film "Tütarlaps Monacost" (Prantsusmaa 2008), Petri Kotwica "Kiilasjää" (Soome 2007), Annemarie Jacir "Meresool" (Palestiina/Prantsusmaa 2008), Paul Kieffer "Araabia ööd" (Luksemburg 2007), Pernille Fisher Christensen "Tantsijad" (Taani/Rootsi 2008)

  15. 2 ühe hoobiga. "Funny Games", "Hellboy 2 : Kuldne armee" / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    2008-01-01

    Mängufilm "Jõhkrad mängud" ("Funny Games") : režissöör Michael Haneke : Suurbritannia - Ameerika Ühendriigid - Saksamaa 2007 ja "Hellboy 2: Kuldne armee" ( "The Golden Army") : režissöör Guillermo del Toro : Ameerika Ühendriigid 2008

  16. Helmut Duddeck*, Jadwiga Frelekº, wojciech, J. szczepekº and

    African Journals Online (AJOL)

    A cade : ic P r e s s , New Yc r k ( l 9 69) ; (b) H. Gun E in e r , N 1 R-. Spektroskopie, 2nd . ed . , Thiee, Stuttgart (l980) . H. Duddeck, %. Kaiser and D. Brosch, Magn. Reson. Che:. 23,. 548 (1985) ,. C. W. Shoppee and S. K. Roy, J. Che. St., 3774 (1963) . C. R. Narayanan and M. S. Parkar , Chen. Ird. , l63 (l974) . Ni. ºleot-ler, E.

  17. Tallinna Kinomajas näidati Põhjamaade tummfilme / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    1997-01-01

    Mängufilmid "Valge orjakaubanduse viimane ohver", režissöör A. Blom : Taani 1911; "Viirastuste vanker", režissöör V. Sjöström : Rootsi 1920; "Maa õnnistus", režissöör G. Sommerfeldt : Norra 1921

  18. Die Insolvenz – historische, literarische und philosophische Aspekte des wirtschaftlichen Scheiterns / Helmut Zipperer

    Index Scriptorium Estoniae

    Zipperer, Helmut

    2016-01-01

    Pankrotiõiguse ajaloolisi (nt XII tahvli seaduste mõju), kirjanduslikke (Gustav Freytagi kaupmeheromaan „Soll und Haben”; Thomas Manni „Buddenbrookid”) ja filosoofilisi aspekte (pankrotimenetlus ja õiglus)

  19. Review: Helmut Kromrey (2006). Empirische Sozialforschung. Modelle und Methoden der standardisierten Datenerhebung und Datenauswertung

    OpenAIRE

    Kuckartz, Udo

    2008-01-01

    Der Autor behandelt in seinem Lehrbuch die Hauptthemen der "traditionellen" empirischen Sozialforschung. Auf mehr als 650 Seiten werden zunächst die wissenschaftstheoretischen und methodischen Grundlagen der empirischen Forschung vorgestellt. Es folgen umfangreiche Teile zu den wichtigsten Methoden der Datenerhebung (Inhaltsanalyse, Beobachtung, Befragung) und der statistischen Datenauswertung. KROMREYs Buch eignet sich sehr gut als Grundlagentext für universitäre Einführungen in die Methoden...

  20. Ühinemist võib vaadelda mitmelt tasandilt / Helmut Bachman

    Index Scriptorium Estoniae

    Bachman, Helmut

    2004-01-01

    Türi vallavolikogu liikme hinnangul on Türi vallale soodsam liituda Türi linnaga, sest liitumine Oisu ja Kabala valdadega tooks kaasa olelusvõitluse. Vallakodanike aktiivsuse ja külaliikumise tähtsusest

  1. Raadi mõis Tartu Ülikooli teenistuses / Helmut Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Helmut, 1930-

    2010-01-01

    1921. aastal kinkis Eesti Vabariik Raadi mõisa Tartu Ülikoolile, hooneid ja maid hakkas kasutama põllumajandusteaduskond, härrastemaja anti Eesti Rahva Muuseumi käsutusse. Põllumajanduslike katsejaamade rajamine Raadile.

  2. Läti väljavaated Maastrichti kriteeriumide täitmiseks / Helmuts Ancans

    Index Scriptorium Estoniae

    Ancans, Helmuts

    2005-01-01

    Ilmunud ka: Kroon & Economy nr. 3, lk. 11-15. Läti valmisolekust euroga liitumiseks, kus kõige problemaatilisemaks teguriks võib kujuneda inflatsioon. Lisad: Maastrichti kriteeriumid; Inflatsiooni mõjutavad pakkumispoolsed tegurid

  3. Mida vaadata pimedatel öödel? / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    2006-01-01

    Lühitutvustused-arvustused 10. Pimedate Ööde Filmifestivali filmidest - "Psühhoterror" (rezh. Yannis Economidis ; Kreeka - Küpros), "Hullem neist hulludest" (rezh. Laurent Achard ; Prantsusmaa - Belgia), "Mehed tööl" (rezh. Mani Haghighi ; Iraan)

  4. Influência da aptidão produtiva (leite ou carne sobre a libido de bodes de raças exóticas e naturais da região semi-árida do nordeste brasileiro Influence of the productive aptitude (milk or meat on the libido of exotic male goats it is naturalized to the semi-arid area from the brazilian northeast region

    Directory of Open Access Journals (Sweden)

    Fernando Carlos Borja dos Santos

    2005-06-01

    Full Text Available Dezesseis reprodutores caprinos agrupados de acordo com a aptidão produtiva (carne ou leite foram avaliados quanto à libido. Em cada grupo racial (Anglo-Nubiano e Pardo-Sertanejo - para leite; e Boer e Moxotó - para carne, havia quatro animais. Cinco fêmeas mestiças de Anglo-Nubiano foram utilizadas, todas elas estrogenizadas. O experimento foi realizado em Patos - PB (região semi-árida do Nordeste brasileiro durante 42 dias, entre agosto e setembro de 2002. Os trinta dias iniciais foram reservados para o período adaptativo dos animais e os últimos doze dias, para o processo intensivo de coleta seminal, que obedeceu a um sistema contínuo e crescente de coletas dividido em três fases, cada uma com quatro dias: fase 1, uma coleta ao dia; fase 2, três coletas ao dia; fase 3, seis coletas ao dia. Durante as coletas seminais, todo o comportamento sexual dos bodes foi monitorado, inclusive a libido. Encontrou-se influência significativa (P Sixteen male goats were agrouped accord to productive aptitude (meat or milk and they were evaluated for the libido. In each racial group (Anglo-Nubiano and Pardo-Sertanejo - for milk; and Boer and Moxotó - for meat being a total of four animals. Five females crosbreed from Anglo-Nubiano in oestrous were used.. The experiment was conducted in Patos - PB (Brazilian Northeast, semi-area region during 42 days from August and September of 2002. The thirty initial days were reserved for the adaptadion period of the animals and the last twelve days the animals were submitted to intensive process of seminal collection in a continuous and growing system of collections divided in three phases, each one with four days: phase 1, a collection a day; phase 2, three collections a day; phase 3, six collections a day. During the seminal collections the whole sexual behavior of the male goats was monitored, besides the libido. The data shown a significant influence (P <0.05 on the productive aptitude as well the

  5. Success with pleasure: MIR interview with Helmut Meysenburg, Head of Brand Strategies, Market Research and Competition at BMW Group

    Directory of Open Access Journals (Sweden)

    2014-05-01

    Full Text Available Sheer driving pleasure is the essence of the BMW brand. For this reason, we have an ideal candidate for our real-world interview in this MIR issue about emotions in marketing. Mr. Meysenburg takes us behind the scenes of the world brand from Bavaria, the success of which makes one think that the promised thrill behind the wheel is definitely not a product of chance …

  6. 2 ühe hoobiga. "Uskumatu Hulk", "Aeg on käes..." / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    2008-01-01

    Seiklusfilm "Uskumatu Hulk" ("The Incredible Hulk") : režissöör Louis Leterrier : Ameerika Ühendriigid 2008 ja ulmefilm "Aeg on käes..." ("The Happening") : režissöör M. Night Shyamalan : peaosas Mark Wahlberg : Ameerika Ühendriigid - India 2008

  7. 85Th Percentile Speed Prediction Model For Bode Saadu– Jebba Road In Kwara State, Nigeria

    Directory of Open Access Journals (Sweden)

    O. O. Joseph

    2014-01-01

    Full Text Available Among the roadway element, horizontal alignment has long been recognized as having a significant effect on vehicle speeds. Unexpectedly tight horizontal curves can lead to accidents as drivers try to negotiate them at too high a speed. Design features, such as curvature and super elevation, are directly related to, and vary appreciably with design speed; while the 85%percentile speed of light vehicle is commonly used as a basis for the design i.e. the speed exceeded by only 15% of the vehicles. Reconnaissance survey of the area was carried out; geometric data were extracted from the working drawing while instantaneous speed were measured manually using stop watch at selected locations. Regression analysis of both the geometric data extracted and the 85th percentile speed evaluated were performed using Statistical Package for Social Sciences (SPSS to formulate simple mathematical model for operating speed. The coefficient of determination(R and coefficient of determination (R2 obtained were 85.2% and 72.6% respectively.In the reported model for 85th percentile vehicular speed, regression parameters were statistically significant for variables, the relationship exists between all the parameters since the both output shows R – sq value was more than 50%. It can be conclude that, the operating speed of the vehicle depends on the Radius (R; Length of curve (Lc; Tangent lengths (TL ; Gradient (G; and Super elevation (e. It is recommended that the model equation obtained could be used to obtained design speed in the study location and similar road network; while a large national research effort aimed at developing speed models for Nigerian situation should be conducted, the results will aid in the development of consistent design and traffic control

  8. Fractional order phase shaper design with Bode's integral for iso-damped control system.

    Science.gov (United States)

    Saha, Suman; Das, Saptarshi; Ghosh, Ratna; Goswami, Bhaswati; Balasubramanian, R; Chandra, A K; Das, Shantanu; Gupta, Amitava

    2010-04-01

    The phase curve of an open loop system is flat in nature if the derivative of its phase with respect to frequency is zero. With a flat-phase curve, the corresponding closed loop system exhibits an iso-damped property i.e. maintains constant overshoot with the change of gain. This implies enhanced parametric robustness e.g. to variation in system gain. In the recent past, fractional order (FO) phase shapers have been proposed by contemporary researchers to achieve enhanced parametric robustness. In this paper, a simple methodology is proposed to design an appropriate FO phase shaper to achieve phase flattening in a control loop, comprising a plant controlled by a classical Proportional Integral Derivative (PID) controller. The methodology is demonstrated with MATLAB simulation of representative plants and accompanying PID controllers. Copyright 2009 ISA. Published by Elsevier Ltd. All rights reserved.

  9. Fencing bodes a rapid collapse of the unique Greater Mara ecosystem

    Science.gov (United States)

    Løvschal, Mette; Bøcher, Peder Klith; Pilgaard, Jeppe; Amoke, Irene; Odingo, Alice; Thuo, Aggrey; Svenning, Jens-Christian

    2017-01-01

    With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes in its history. The 668,500-hectare Greater Mara is of crucial importance for the great migrations of large mammals and for Maasai pastoralist culture. However, the magnitude and pace of these fencing processes in this area are almost completely unknown. We provide new evidence that fencing is appropriating land in this area at an unprecedented and accelerating speed and scale. By means of a mapped series of multispectral satellite imagery (1985-2016), we found that in the conservancies with the most fences, areal cover of fenced areas has increased with >20% since 2010. This has resulted in a situation where fencing is rapidly increasing across the Greater Mara, threatening to lead to the collapse of the entire ecosystem in the near future. Our results suggest that fencing is currently instantiating itself as a new permanent self-reinforcing process and is about to reach a critical point after which it is likely to amplify at an even quicker pace, incompatible with the region’s role in the great wildebeest migration, wildlife generally, as well as traditional Maasai pastoralism.

  10. 1980–2008: The Illusion of the Perpetual Money Machine and What It Bodes for the Future

    OpenAIRE

    Didier Sornette; Peter Cauwels

    2014-01-01

    We argue that the present crisis and stalling economy that have been ongoing since 2007 are rooted in the delusionary belief in policies based on a “perpetual money machine” type of thinking. We document strong evidence that, since the early 1980s, consumption has been increasingly funded by smaller savings, booming financial profits, wealth extracted from house price appreciation and explosive debt. This is in stark contrast with the productivity-fueled growth that was seen in the 1950s and ...

  11. Modelling Defects Acceptors And Determination Of Electric Model From The Nyquist Plot And Bode In Thin Film CIGS

    Directory of Open Access Journals (Sweden)

    Demba Diallo

    2015-08-01

    Full Text Available Abstract The performance of the chalcopyrite material CuInGaSe2 CIGS used as an absorber layer in thin-film photovoltaic devices is significantly affected by the presence of native defects. Multivalent defects e.g. double acceptors or simple acceptor are important immaterial used in solar cell production in general and in chalcopyrite materials in particular. We used the thin film solar cell simulation software SCAPS to enable the simulation of multivalent defects with up to five different charge states.Algorithms enabled us to simulate an arbitrary number of possible states of load. The presented solution method avoids numerical inaccuracies caused by the subtraction of two almost equal numbers. This new modelling facility is afterwards used to investigate the consequences of the multivalent character of defects for the simulation of chalcopyrite based CIGS. The capacitance increase with the evolution of the number of defects C- f curves have found to have defect dependence.

  12. 1980–2008: The Illusion of the Perpetual Money Machine and What It Bodes for the Future

    Directory of Open Access Journals (Sweden)

    Didier Sornette

    2014-04-01

    Full Text Available We argue that the present crisis and stalling economy that have been ongoing since 2007 are rooted in the delusionary belief in policies based on a “perpetual money machine” type of thinking. We document strong evidence that, since the early 1980s, consumption has been increasingly funded by smaller savings, booming financial profits, wealth extracted from house price appreciation and explosive debt. This is in stark contrast with the productivity-fueled growth that was seen in the 1950s and 1960s. We describe the transition, in gestation in the 1970s, towards the regime of the “illusion of the perpetual money machine”, which started at full speed in the early 1980s and developed until 2008. This regime was further supported by a climate of deregulation and a massive growth in financial derivatives designed to spread and diversify the risks globally. The result has been a succession of bubbles and crashes, including the worldwide stock market bubble and great crash of October 1987, the savings and loans crisis of the 1980s, the burst in 1991 of the enormous Japanese real estate and stock market bubbles, the emerging markets bubbles and crashes in 1994 and 1997, the Long-Term Capital Management (LTCM crisis of 1998, the dotcom bubble bursting in 2000, the recent house price bubbles, the financialization bubble via special investment vehicles, the stock market bubble, the commodity and oil bubbles and the current debt bubble, all developing jointly and feeding on each other until 2008. This situation may be further aggravated in the next decade by an increase in financialization, through exchange-traded-funds (ETFs, speed and automation, through algorithmic trading and public debt, and through growing unfunded liabilities. We conclude that, to get out of this catch 22 situation, we should better manage and understand the incentive structures in our society, we need to focus our efforts on our real economy and we have to respect and master the art of planning and prediction. Only gradual change, with a clear long term planning, can steer our financial and economic system from the turbulence associated with the perpetual money machine to calmer and more sustainable waters.

  13. Development of Graphical Pole-Zero, Root-Locus, Bode, Nyquist, and Nichols Responses Using the OPTSYSX Program.

    Science.gov (United States)

    1984-09-01

    locus gains and roots A positive unity feedback system may be analyzed by specifying a negative gain range vice a positive gain range. S 33...0- L 00 .0-0- 0 C O0. L CO. 0- m a- 00ocooooo0000000c󈧄ococ000000000Cocc00oo0c’c𔃺c0 i t gilt I n ii of X 0 OR U.1 of (X I lilt US.’ 11 OZ *. I...Linear Control System Analy!sis and D e si, n: Convent&ional an-q51rfi-IUZFaw Tri117 DiStefanc III, J.J., Stubberud, A.R., and Williams,IJ, Feedback

  14. Review: Helmut Kromrey (2006. Empirische Sozialforschung. Modelle und Methoden der standardisierten Datenerhebung und Datenauswertung [Social Research Methods. Models and Methods of Standardized Data Collection and Data Analysis

    Directory of Open Access Journals (Sweden)

    Udo Kuckartz

    2008-01-01

    Full Text Available In the new edition of his textbook, KROMREY outlines the basic principles of "traditional" empirical social research. The 650 pages of the book address the foundations of scientific theory and methods within empirical research. There are also extensive explanations of the most important methods of data collection (content analysis, observation, survey and of statistical analyses of data. This book would be a very suitable textbook for introductory university courses in the methods of empirical social research. The text includes many examples and is written in a very understandable style. Qualitative research methods are only mentioned marginally in the "Alternative Research Paradigms" section. URN: urn:nbn:de:0114-fqs0801240

  15. Strafbare Beleidigung eines ausländischen Staatsoberhaupts durch politische Satire? – Was kann Deutschland aus dem Fall Böhmermann lernen? / Helmut Satzger

    Index Scriptorium Estoniae

    Satzger, Helmut

    2017-01-01

    Poliitilisest satiirist Türgi presidendi Erdogani kohta solvava luuletuse esitanud koomiku Jan Böhmermanni juhtumit taustal ja Saksamaa karistusseadustiku §st 103, mis käsitleb võõrriikide esindajate solvamist

  16. A globalização no Brasil: responsável ou bode expiatório? Globalization in Brazil: guilty or scapegoat?

    Directory of Open Access Journals (Sweden)

    Paulo Kliass

    2008-09-01

    Full Text Available After the sequence of structural adjustments decisions suggested by the IMF, Brazilian economy became wider opened, as the consequences from financial globalization were stronger than those from commercial globalization. Nevertheless, social and economical reality didn't show much improvement. On the contrary, figures on economic increase and inequalities show Brazil behind the average of developing countries. Even if the effects caused by "mondialisation" on weakened economies are well known, globalization can not be taken as the only guilty of weak economic increase, for maintaining the high level of inequalities or for the increase of precariousness. Responsibility must be searched on high inequalities in where operates "mondialisation", on weakness of public policies, on irresponsible way of opening of the economy and in fiscal policy in favor of financial sector. Other countries have reached quite different results, once the have adopted different public policies, which goal was to establish control and reduction upon the negatives effects of globalization.

  17. Kodu-uurija luule- ja fototeosega / Hannes Oja

    Index Scriptorium Estoniae

    Oja, Hannes

    1999-01-01

    rets. rmt.: Joonuks, Helmut. Õhtu, nagu tulekahi : sõja- ja lemmelaulud. Rakvere : H. Joonuks, 1998. 182 lk.; Joonuks, Helmut. Kirjanduslikke paiku Eestis : [fotoalbum]. Tallinn : Koolibri, 1999. 176 lk.

  18. Browse Author Index

    African Journals Online (AJOL)

    Items 651 - 700 of 1198 ... Kloos, Helmut · Kloos, Helmut · Kloos, Helmut · Kloos, Helmut · Koblinsky, M · Kogi-Makau, W · Koopman, Simone · Korra, Antenane · Kruseman, G · Kullgren, Gunnar · Kuma, T · Kumbi, S · Kumbi, S · Kume, A · Kumie, A · Kumie, A · Kumie, Abera · Kumie, Abera · Kumie, Abera · Kumie, Abera · Kuru ...

  19. A vocação política do teatro musical contemporâneo: o exemplo de três obras de Mauricio Kagel, Hans Werner Henze e Helmut Lachenmann

    Directory of Open Access Journals (Sweden)

    Ledice Fernandes de Oliveira Weiss

    2014-12-01

    Full Text Available O presente artigo visa identificar os meios pelos quais três obras de teatro musical contemporâneo incorporam em sua própria linguagem musical, técnico-instrumental e cênica uma preocupação eminentemente política, que lhes leva, por diferentes vias, a inovar o gênero.

  20. 77 FR 4881 - Commercial Driver's license (CDL) Standards; Rotel North American Tours, LLC; Application for...

    Science.gov (United States)

    2012-01-31

    ... Endres, Helmut Erbersdobler, Reinhard Freudenstein, Alexander Friedl, Peter Hess, Gerhard Kinateder, Hermann Lichtenauer, Karl Lippl, Horst Mahl, Franz Manzinger, Fabian Maurer, Rudolf Ramsl, Paul Schl gl...

  1. Bode, Barbara. Las campanas del silencio. Destrucción y creación en los Andes. Lima: Fondo Editorial del Congreso del Perú, 2015, 521 pp.

    OpenAIRE

    Donayre Miranda, Fabio

    2016-01-01

    Reseña el argumento del libro destacando las maneras como las circunstancias políticas, eclesiales y culturales dieron forma a la interpretación que la población de Huaraz dio al desastre desatado por el terremoto de 1970 en el callejón de Huaylas.

  2. Foundation Elements for Naval Low-Rise Buildings

    Science.gov (United States)

    2009-10-01

    hydroxyl groups (Hillis, 1984; Saheb and Jog, 1999). Cross-linking of lignin networks and an increased proportion of crystalline cellulose may...Science at Virginia Polytechnic Institute and State University. Krawinkler, Helmut, Parisi, Francisco, Ibarra , Luis, Ayoub, Ashraf, and Medina...for the degree of Master of Science in civil engineering at Washington State University. Krawinkler, Helmut, Parisi, Francisco, Ibarra , Luis

  3. Aasta moekunstnik on Oscar de la Renta

    Index Scriptorium Estoniae

    2000-01-01

    New Yorgis American Fashion Awards tseremoonial jagati auhindu: aasta parim naisterõivaste kujundaja Oscar de La Renta, parim meesteriiete looja Helmut Lang, elutöö preemia itaalia moekunstnik Valentinole, rahvusvahelise moekunsti auhind Jean Paul Gaultier'ile

  4. Eestlaste matusepaik Rootsis Frösö saarel / Uno Schultz

    Index Scriptorium Estoniae

    Schultz, Uno, 1956-

    2008-01-01

    Frösö kiriku taga surnuaias, valgete ristide ja hauakivide all puhkavad: Elmar Aunpuu, Aarne Meri, Heino Albo, Hindrek Lipp, Kalju Mälk, Heinrich Koppel, Sulev Paju, Eugenius Gorski, Edgar Toompuu, Helmut Lillevars, Venda Oskar, Walentin Riis

  5. 75 FR 33661 - Commercial Driver's License (CDL) Standards; Rotel North American Tours, LLC; Application for...

    Science.gov (United States)

    2010-06-14

    ... Dangl Rudolf Ramsl Reinfried Dangl Paul Schl gl Herbert Erber Walter Schreiner Helmut Erbersdobler Josef Stockinger Wilhelm Fuchs Josef Vogl ] Peter Hess Klaus Weber Michael Huber Markus W lfl Gerhard Kinateder...

  6. A large Cerenkov counter

    CERN Multimedia

    1981-01-01

    The photo shows the vertex Cerenkov counter C0 back side (with 12 mirrors) of the NA9 experiment. On foreground are members of the team (CERN and Wuppertal Uni), Salvo .., Manfred Poetsch, ..., Jocelyn Thadome, Helmut Braun, Heiner Brueck.

  7. Raamatututvustus / Rein Põder

    Index Scriptorium Estoniae

    Põder, Rein, 1943-

    1995-01-01

    Rousseau, Jean-Jacques. Üksildase uitaja mõtisklused; Hill, Susan. Proua de Winter; Kõrvemaast põhjarannani : Kuusalu kihelkonna kirjanduslik-kodulooline antoloogia / Koost. Helmut Elstrok; Tead.toim. Oskar Kuningas

  8. Avalikul loengul räägitakse muusikast kui eluks vajalikust ainest

    Index Scriptorium Estoniae

    2006-01-01

    Tallinna Ülikooli kunstide teaduskonna saalis esineb 27. novembril avaliku loenguga "Muusika kui eluks vajalik aine" Hamburgi muusika- ja teatriülikooli muusikateraapia instituudi direktor professor Hans-Helmut Decker-Voigt

  9. Produkthaftungsgesetz und Bibliotheken

    OpenAIRE

    Meyer, Hans-Burkard

    2002-01-01

    Produkthaftungsgesetz und Bibliotheken. - In: Bibliotheksdienst. 25. 1991. S. 706-709. - Auch ersch. in: Gutachtensammlung zum Bibliotheksrecht / [Red.: Helmut Rösner]. - Wiesbaden : Harrassowitz, 2002. - S. 304-306. - (Bibliotheksrecht ; 1)

  10. Lutshije dizainerõ muzhkoi odezhdõ 2004 goda / Zhanna Paulus

    Index Scriptorium Estoniae

    Paulus, Zhanna

    2005-01-01

    Meestemoe demonstratsioonid Milanos näitasid moetendentse 2005. aastaks. Meesterõivaste parimateks disaineriteks on moeasjatundajate arvates Helmut Lang, Ozwald Boateng, Miuccia Prada, Jean Paul Gaultier ja Giorgio Armani

  11. Book Review: "Water Resources Management in Ethiopia ...

    African Journals Online (AJOL)

    Abstract. Water Resources Management in Ethiopia: Implications for the Nile Basin. Edited by: Helmut Kloos and Worku Legesse (With 17 contributors) Cambria Press: Amherst: New York; 2010. Hard Cover, 415 pages (with 14 chapters and Index) ...

  12. Heads of the Estonian Security Police

    Index Scriptorium Estoniae

    2011-01-01

    Ülevaade Kaitsepolitsei juhtide Helmut Traugott Veemi, Eduard-Hans-Kristian Alveri, Eduard Lensini, Johan Soomani, August Tuulse (Tõns, Tenson), Konstantin Kirsimägi (Kirschberg), Tanel Võhma (Daniel Võhman) elust ja tegevusest

  13. Kaitsepolitsei juhid

    Index Scriptorium Estoniae

    2011-01-01

    Ülevaade Kaitsepolitsei juhtide Helmut Traugott Veemi, Eduard-Hans-Kristian Alveri, Eduard Lensini, Johan Soomani, August Tuulse (Tõns, Tenson), Konstantin Kirsimägi (Kirschberg), Tanel Võhma (Daniel Võhman) elust ja tegevusest

  14. The International Symposium on Si-Based Molecular Beam (4th) held in Anaheim, California, on 29 April-3 May 1991

    Science.gov (United States)

    1992-04-14

    Werner Wegscheider, Karl Eberl, Gerhard Abstreiter, Hans Cerva , and Helmut Oppolzer DIRECT IMAGING OF ORDERING IN Si-Ge ALLOYS, ULTRATHIN SUPERLATTICES...ABSTREITER!, HANS CERVA ** AND HELMUT OPPOLZERe *Walter Schottky Institut, Technieche Universitit MUnchen, Am Coulombwall, D-8046 Garching, Federal...AppI. Phys. Lett. A*, 329 (1989). 8. W. Wegachelder, K. Ebert, G. Abstrelter, H. Cerva and H. Oppolzer, AppI. Phys. Lett. §,7 14% (1990). 9. J. W

  15. in Patients with Mustard Lung

    Directory of Open Access Journals (Sweden)

    ShahrzadM Lari

    2013-05-01

    Full Text Available   Introduction: Chronic Obstructive Pulmonary Disease (COPD secondary to sulfur mustard exposure, known as mustard lung, is an important late pulmonary complication. The BODE (Body mass index, Obstruction, Dyspnea, and Exercise index has been established as a valuable tool for determining the adverse consequences of COPD. The aim of this study was to evaluate the role of the BODE index in patients with mustard lung.   Materials and Methods: Eighty-two consecutively stable patients with mustard lung with all levels of severity were entered this study. The following parameters were recorded in all patients: standard spirometry, pulse oximetry, health-related quality of life, the BODE index. Additionally, the severity of COPD was determined by GOLD (Global initiative for chronic Obstructive Lung Disease staging. The correlation of the BODE index with pulmonary parameters was determined. Results: The mean age of the patients was 47.30±7.08 SD years. The mean BODE index was 3.16±2.25 SD. There was a statistically significant inverse correlation between the BODE index and oxygen saturation (r=-0.30, p=0.007. Also a statistically significant correlation was found between the BODE index and quality of life (r=0.80, p=0.001. The BODE index was not correlated with age of the patients and duration of disease. Conclusions: The results of this study showed that the BODE index is correlated with important clinical parameters and can be used in clinical practice

  16. Electrochemical copolymerization of N-methylpyrrole and 2, 2 ...

    Indian Academy of Sciences (India)

    ... dispersive X-ray analysis (EDX) and electrochemical impedance spectroscopy (EIS). The capacitive behaviours of the modified electrodes were defined via Nyquist, Bode-magnitude, Bode-phase and admittance plots. The equivalent circuitmodel of R(C(R)(QR)(CR)) was performed to fit theoretical and experimental data.

  17. Electrochemical copolymerization of N-methylpyrrole and 2,2 ...

    Indian Academy of Sciences (India)

    electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and electrochemical impedance spectroscopy. (EIS). The capacitive behaviours of the modified electrodes were defined via Nyquist, Bode-magnitude, Bode-phase and admittance plots. The equivalent circuit model of R(C(R)(QR)(CR)) was performed to fit ...

  18. Beyond and behind the fingerprints of oxidative stress in age-related diseases: Secrets of successful aging.

    Science.gov (United States)

    Polidori, M Cristina; Scholtes, Marlies

    2016-04-01

    Several years after the first publication of the definition of oxidative stress by Helmut Sies, this topic is still focus of a large body of attention and research in the field of aging, neurodegeneration and disease prevention. The conduction of clinical and epidemiological research without a solid biochemical rationale has led to largely frustrating results without being able to disprove the oxidative stress hypothesis. The present work is dedicated to Helmut Sies and describes the successful scientific approach to bench-to-bedside (-to-behavior) oxidative stress clinical research. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Kodukoharaamatud / Voldemar Miller

    Index Scriptorium Estoniae

    Miller, Voldemar, 1911-2006

    1996-01-01

    Virve Orav. Narva-Jõesuu kodu-uurija pilguga. 1993. Helmut Elstrok. Padaorust Viru mereni. Viru-Nigula - Tln., 1994. Helmut Elstrok. Kõrvemaast Põhjarannani. Kuusalu - Tln.-Tapa, 1995. Lembit Arulo. Nii see olla võis... Põhjaranniku külaelust läbi aegade. Tln., 1994. Robert Nerman. Kopli. Miljöö, olustik, kultuurilugu 1918-1940. Tln., 1995. Ain Sarv. Varjusurmast tõusnud. Eestirootslaste ja Eestirootsi alade saatusest pärast Teist maailmasõda, Tln., 1994. Jaan Ellen. Kuhu kõik nad jäid? Tõsilugu Urvaste ürgorust. Tln., 1994

  20. Avafestivalile andis värvi Aki Kaurismäki / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2011-01-01

    Tallinna Pimedate Ööde esimesest Filmifestivalist. PÖFF'i juhi Tiina Loki, Kanal 2 programmidirektori Olle Mirme, PÖFFI pressijuhi Helmut Jänese, režissööri ja produtsendi Jaak Kilmi ning 1997 aasta PÖFF'i külalise soome filmirežissööri Aki Kaurismäki arvamus

  1. Die skeppingsordeninge en homoseksualiteit | Naudé | HTS ...

    African Journals Online (AJOL)

    The ordination of creation and homosexuality The idea of creation ordinances is treated according to the theologies of Emil Brunner, Karl Barth and Helmut Thielicke in the light of the conjugation of the ordinance and homosexuality by Heinrich Ott on the one hand, and between the ordinance and the relation between ...

  2. Külapiltnik rahvakultuuri säilitajana / Laine Vester

    Index Scriptorium Estoniae

    Vester, Laine

    2006-01-01

    Hanila Muuseumi Seltsi fotonäitused: "Sündinud Eesti Vabariigis. Talulapsed 1920-1940" Kinksi küla päevapiltniku Karl Tähe klaasnegatiivide kogu järgi ja "Kodukoht kolmkümmend aastat tagasi: maastikud, majad, inimesed" Helmut Polbergi kogust

  3. Eesti Vabariigi aukonsul Baden-Württembergis korraldas vastuvõtu / Meeli Bagger

    Index Scriptorium Estoniae

    Bagger, Meeli, 1958-

    2005-01-01

    6. juunil 2005 Audi-Forumis. Helmut Aurenz, ettevõtja ja aukonsul tutvustas Eestit, liidumaa peaminister Günther Oettinger rõhutas väikeriikide tähendust Euroopa Ühenduses, esinesid Clyde Kull ja Raivo Palmaru, klaveril musitseeris Kalle Randalu

  4. Kolmest Tallinna Ülikooli Humboldti stipendiaadist / Tiina Tamkivi

    Index Scriptorium Estoniae

    Tamkivi, Tiina

    2014-01-01

    Tallinna Ülikooli külastas jaanuaris teadlasi toetava fondi Alexander von Humboldt Stiftung president ja Berliini Tehnikaülikooli keemiaprofessor Helmut Schwarz. Tallinna Ülikoolist on Humboldti stipendiumi pälvinud kolm teadlast - professor Peeter Järvelaid, ajaloolane Juhan Kreem ja kunstiajaloolane Kersti Markus, kes lisavad artiklis ka omapoolsed selgitused

  5. South African Journal of Chemistry - Vol 56 (2003)

    African Journals Online (AJOL)

    A Stable Glutamate Biosensor Based on MnO2 Bulk-modified Screen-printed Carbon Electrode and Nafion(R) Film-immobilized Glutamate Oxidase · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Negussie W Beyene, Helmut Moderegger, Kurt Kalcher ...

  6. Bulletin of the Chemical Society of Ethiopia - Vol 1, No 1 (1987)

    African Journals Online (AJOL)

    HighfieidH andC NMR of 5-oxygenated of cholestane-6-oxime derivatives · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Helmut Duddeck, Jadwiga Frelek, Wojciech J. szczepek, Wladislaw J. Rodewald ...

  7. Author Details

    African Journals Online (AJOL)

    Duddeck, Helmut, Ethiopia. Vol 1, No 1 (1987) - Articles Highfieid 1H and 13C NMR of 5-oxygenated of cholestane-6-oxime derivatives. Abstract PDF · Vol 1, No 1 (1987) - Articles Isoflavonoids from taverniera abyssinica. Abstract PDF. ISSN: 1726-801X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers ...

  8. Cosmogenesis and Collapse

    OpenAIRE

    Pearle, Philip

    2010-01-01

    Comment: For a festschrift in Foundations of Physics in honor of Daniel Greenberger and Helmut Rauch in Foundations of Physics. This updates the previous version by adding an appendix (Appendix B) which contains the exact solution of a partial differential equation of importance in the paper

  9. Väike Tokyo / Aleksander Tsapov

    Index Scriptorium Estoniae

    Tsapov, Aleksander

    2007-01-01

    Londoni Canary Wharfi piirkonnast ja uutest kõrghoonetest (arhitektid: Norman Foster, Cesar Pell, Richard Rogers, Renzo Piano), Pariisi La Defense (AB Valode et Pistre, Thomas Myne), Berliini Potzdamer Platz'i (Helmut Jahn, Hans Kolhoff, üldplaneering: R. Piano) ning Barcelona Forum 2004/Diagonal al Mar'i (Jacques Herzog, Pierre de Meuron) arendusprojektidest

  10. 1. X toimus Hanila Muuseumi Seltsi pidulik koosolek... / Laine Vesker

    Index Scriptorium Estoniae

    Vesker, Laine

    2005-01-01

    Anti üle tunnistused seltsi auliikmetele, kelleks on Lennart Meri, Heinz Valk, Saima Mägi, Lily Kocins, Helmut Polberg, Mai Schröder, Eimar Kaasik, Hermi Vain, Elmar Vesker, Õie Pärna, Marju Heldema, Piret Leiumaa ja Salme Valdmets

  11. Download this PDF file

    African Journals Online (AJOL)

    1988-02-04

    Salah S. Massoud and Helmut Sigel*. Institute of Inorganic Chemistry, University of Basel,. Spitalstrasse 51, CH-4056 Basel, Switzerland. (Received February 4, 1988). ABSTRACT. The stability constants of 1:1 complexes formed between Ca2+ or Ca2+ and GMP2- were determined by potentiometric pH titration in aqueous.

  12. Ilmus 20. sajandi suurim raamat

    Index Scriptorium Estoniae

    1999-01-01

    Kirjastus Taschen andis austraalia fotograafi Helmut Newtoni elutöö kokkuvõttena välja tema 480-leheküljelise luksusalbumi 'Big Nude'. 70 cm kõrgune ja 50 cm laiune raamat kaalub 30 kilo, maksab 24000 kroon, trükiti 10000 eksemplari. Erilise raamatupuldi albumi jaoks kujundas Philippe Starck

  13. 2017-11-01T21:23:50Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    Paule, Peter; Research Institute for Symbolic Computation, Johannes Kepler University Linz, A-4040 Linz, Austria. Prodinger, Helmut; The John Knopfmacher Centre for Applicable Analysis and Number Theory, University of the Witwatersrand, Johannesburg 2050, South Africa. We describe the q-Engel series expansion for ...

  14. Obnazhonka s molotka

    Index Scriptorium Estoniae

    2008-01-01

    Christie'se oksjonil New Yorgis tuleb müügile saksa kollektsionääri Gert Elferingi kollektsioon kuulsuste aktifotodest. Kollektsioonis on 135 fotot maailmakuulsatelt fotograafidelt Helmut Newton, Richard Avedon, Man Ray, Diane Arbus, Horst P. Horst ja teised

  15. Eestlaste ristid Frösö kiriku juures / Uno Schultz

    Index Scriptorium Estoniae

    Schultz, Uno, 1956-

    2005-01-01

    12. sajandi lõpus Frösö saarele ehitatud samanimeline kirik on Rootsis populaarne laulatuskirik. Kiriku taha surnuaeda on maetud eestlased: Aunpuu, Elmar, Meri, Aarne, Albo, Heino, Lipp, Hindrek, Mälk, Kalju, Koppel, Heinrich, Paju, Sulev, Gorski, Eugenius, Toompuu, Edgar, Lillevars, Helmut, Oskar, Venda, Riis, Walentin

  16. Saksa vaim Kunstihoones

    Index Scriptorium Estoniae

    2001-01-01

    Fotokunsti väljapanek "Ajastu vaim. Saksa moefotod 1945-1995". Kuraator F. C Gundlach. Esindatud kunstnikud Helmut Newton, Wolfgang Tillmans, Jürgen Teller, Charlotte Rohrbach, Norbert Leonard, Willy Maywald, Regi Relang, Hubs Flöter, Herbert Tobias, Rico Puhlmann, Will McBride, Charlotte March.

  17. Don't Fence Me In: The Liberation of Undomesticated Critique

    Science.gov (United States)

    Ruitenberg, Claudia

    2004-01-01

    In response to Helmut Heid's critique of domesticated philosophical critique, I focus on the metaphor of domestication, which is central to his article. Drawing on the work of Jacques Derrida, I offer a deconstructive critique of the opposition between domesticated and undomesticated critique, arguing that a clear conceptual demarcation between…

  18. Viis aastat iPhone’i / Tõnu Ojala

    Index Scriptorium Estoniae

    Ojala, Tõnu, 1969-

    2012-01-01

    Jaanuar ajaloos: 9. jaanuaril 2007. aastal esitles Apple'i juht Steve Jobs esimest iPhone'i. 13. jaan. 1942 päästis Saksa katselendur Helmut Schenck esimese lendurina oma elu katapulteerumisega. 12. jaan. 1907 sündis Sergei Koroljov

  19. Raamat piilub seltsiellu ja rändab ajalukku / Kerttu Jänese

    Index Scriptorium Estoniae

    Jänese, Kerttu, 1981-

    2007-01-01

    Rmt.: Vivat Academia : üliõpilasseltsid ja -korporatsioonid Eestis / [peatoimetaja Helmut Piirimäe ; tegevtoimetaja Meelis Burget. - [Tartu] : Eesti Üliõpilaste Seltsi Kirjastus, 2007 ; Eesti lipp 120 : 5. juunil 2004 Tartus peetud teadusliku konverentsi materjalid / Meelis Burget, Toomas Hiio. - Tartu : EÜS Kirjastus, 2007

  20. Ernst Odefey 1882 1964: Leben und Werk des Hamburger Maiers und Grafikers(Ernst Odefey 1882 1964: Life and Work of the Hamburger Painter and Printmaker)

    Science.gov (United States)

    2016-01-01

    Engagement, einen geeigneten und reprasentativen Ausstellungsort zu finden . Unser ganz besonderer Dank gilt der Helmut-Schmidt-Universitat und Herrn...Tier- und Landschaftsmalerei. Ludwig von Hofmann (1903 nach Weimar berufen) gilt als einer der deutschen Hauptvertreter der naturlyrischen Variante...Schneider, der Maler gro13er Figurenkompositionen, und Theodor Hagen, der als der Haupt- vertreter der Weimarer Malerschule gilt und der bis zu

  1. Tuumafüüsik möllab BMW-s nagu jaksab / Toomas Pärna

    Index Scriptorium Estoniae

    Pärna, Toomas, 1966-

    2004-01-01

    Bayerische Motoren Werke (BMW) brändi maine kujundamisest, BMW juhi Helmut Panke poolt ärgitatud pidevast tootearendusest ettevõttes ning kiire arenguga seotud võimalikest riskidest. Lisa: BMW-de müük Eestis Vt. samas: BMW luksuskupee müüdud

  2. Sport und soziale Integration

    OpenAIRE

    Hofmann, Jürgen

    2012-01-01

    Sport und soziale Integration : Chancen, Probleme und Perspektiven für Städte und Kommunen ; Tagungsband der gleichnamigen Tagung am 28. und 29. Juni 2011 in Augsburg / Helmut Altenberger ... (Hrsg.). - Hamburg : Feldhaus, Ed. Czwalina, 2012. - 104 S. - (Sportwissenschaft und Sportpraxis ; 161)

  3. Augsburger Volkskundliche Nachrichten: 01/2002

    OpenAIRE

    2010-01-01

    Inhalt: • Helmut Krajicek: Die Sonderausstellung. Ein zentrales Thema der Öffentlichkeitsarbeit im Museum. • Eva Appel: Museen im Internet – einige Beobachtungen. • Mouna Dix: E-Mail-Hoaxes – Moderne Sagen im Internet. • Michael Schwendinger: Was steckt hinter einem Spuk? Geistererscheinungen in Volksglauben und Parapsychologie. • Berichte, Kongress, Ausstellungen, Publikationen, Preisrätsel, Veranstaltungskalender

  4. Plagiate finden und vermeiden

    Directory of Open Access Journals (Sweden)

    Dollfuß, Helmut

    2015-08-01

    Full Text Available This issue of GMS Medizin – Bibliothek – Information puts a focus on plagiarism assessment and prevention. Furthermore you will find news from the AGMB and Oliver Obst is starting a series of publications on mobile library applications. Guest editors for this focus issue are Natascha Miljković and Helmut Dollfuß.

  5. Haapsalus hakkab õudne / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    PÖFF-i abiga toimub Haapsalus õudusfilmide festival, idee autoriks reklaamiagentuuri Zavood juht Marek Reinaas. Eesti Kunstiakadeemia tudengid esinevad videoinstallatsioonide ja perfomance'ite eriprojektiga "Hirmurõõm". Lisatud festivali programmijuhi Helmut Jänese vastus ekstreemse õudusfilmi "Kannibali holokaust" näitamise kohta

  6. Multiplex kino Dresdenis / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    1999-01-01

    Hoone projekteerisid austria arhitektid Wolf D. Prix ja Helmut Swiczinsky arhitektuuribüroost Coop Himmelblau. Hoone on jaotatud kaheks ئ betoonist kinosaale sisaldav plokk ning klaasist 'ümberkukkuv' fuajee, mille interjööri ilmestavad betoonpostidele toetuvad metalltrepid.

  7. Parallel and Distributed Computing.

    Science.gov (United States)

    1986-12-11

    Shmoys A. Wigderson .1 Halpei- G. Mago M. Sipser A. Yao The vitorks!h3p w’ill be held at the Institute’s ne%% building at 1000 Centennial Drive...Simons IBM San Jose Michael Sipser MSRI Bruce Smith Rob Smith MCC L. Snyder University of Washington Danny Soroker UC Berkeley Helmut Stern UC Berkeley G.W

  8. The control of calcium signaling in the heart

    African Journals Online (AJOL)

    Dr Olaleye Samuel

    pipe water supplied by the New River Water Company. As this water contains .... Figure modified from (Eisner, Bode, Venetucci, & Trafford 2012). .... is this negative feedback system which is responsible for beat to .... Circulation Research, 87,.

  9. Alcohol metabolism: role in toxicity and carcinogenesis.

    Science.gov (United States)

    Badger, Thomas M; Ronis, Martin J J; Seitz, Helmut K; Albano, Emanuele; Ingelman-Sundberg, Magnus; Lieber, Charles S

    2003-02-01

    This article contains the proceedings of a symposium at the 2002 RSA Meeting in San Francisco, organized and co-chaired by Thomas M. Badger, Paul Shih-Jiun Yin, and Helmut Seitz. The presentations were (1) First-pass metabolism of ethanol: Basic and clinical aspects, by Charles Lieber; (2) Intracellular CYP2E1 transport, oxidative stress, cytokine release, and ALD, by Magnus Ingelman-Sundberg; (3) Pulsatile ethanol metabolism in intragastric infusion models: Potential role in toxic outcomes, by Thomas M. Badger and Martin J.J. Ronis; (4) Free radicals, adducts, and autoantibodies resulting from ethanol metabolism: Role in ethanol-associated toxicity, by Emanuele Albano; and (5) Gastrointestinal metabolism of ethanol and its possible role in carcinogenesis, by Helmut Seitz.

  10. German Business in Russia

    Directory of Open Access Journals (Sweden)

    Irakliy D. Gvazava

    2013-01-01

    Full Text Available Since Perestroika German-Russian relationships have been steadily developing fueled by close contacts between the leaders of both countries. Boris Yeltsin and Helmut Kohl, Vladimir Putin and Gerhard Schröder, Dmitry Medvedev and Angela Merkel had friendly relations resulted in some fruitful business projects, intergovernmental economic forums etc. In my article I will consider the activities of German companies in Russia, advantages, barriers and expectations

  11. A General Surface Representation Module Designed for Geodesy

    Science.gov (United States)

    1980-06-01

    Nr. 77. Rapp, R.H. (1978): Results of the application of least-squares collocation to selected geodetic problems. In: Moritz , H. and H. SUnkel (edt...report was prepared by Dr. Hans Slinkel, assistant to -Dr. Helmut Moritz , Professor, Technical University at Graz and Adjunct Professor, Department of...the inversion- free prediction and least-squares collocation . 2.2. 1 Inversion-free prediction. In many cases we face the following situation: there is

  12. Looking Forward: American Foundations between Continuity and Change

    OpenAIRE

    Hammack, David; Anheier, Helmut K. (Prof. Dr.)

    2010-01-01

    Foundations play an essential part in the philanthropic activity that defines so much of American life. No other nation provides its foundations with so much autonomy and freedom of action as does the United States. Liberated both from the daily discipline of the market and from direct control by government, American foundations understandably attract great attention. As David Hammack and Helmut Anheier note in this volume, "Americans have criticized foundations for... their alleged conservat...

  13. American foundations : roles and contributions

    OpenAIRE

    Anheier, Helmut K.; Hammack, David

    2010-01-01

    Foundations play an essential part in the philanthropic activity that defines so much of American life. No other nation provides its foundations with so much autonomy and freedom of action as does the United States. Liberated both from the daily discipline of the market and from direct control by government, American foundations understandably attract great attention. As David Hammack and Helmut Anheier note in this volume, "Americans have criticized foundations for... their alleged conservat...

  14. American Foundations: Their Roles and Contributions in Society

    OpenAIRE

    Anheier, Helmut K. (Prof. Dr.)

    2011-01-01

    Foundations play an essential part in the philanthropic activity that defines so much of American life. No other nation provides its foundations with so much autonomy and freedom of action as does the United States. Liberated both from the daily discipline of the market and from direct control by government, American foundations understandably attract great attention. As David Hammack and Helmut Anheier note in this volume, “Americans have criticized foundations for . . . their alleged conser...

  15. Miljonid sotsmaksust priid / Ralf-Martin Soe

    Index Scriptorium Estoniae

    Soe, Ralf-Martin

    2009-01-01

    Eesti tippadvokaadid teenivad enamiku oma kõrgest sissetulekust dividendidena ja ainult 10-20% pealt maksavad sotsiaalmaksu. Küsimusele, miks Te olete otsustanud juhatuse liikmetele üsna kõrget töötasu maksta, vastavad Sven Papp ja Aivar Pilv. Küsimusele, miks Te ei maksa juhatuse liikmetele tasu, vastavad Helmut Pikmets, Veikko Toomere ja Leon Glikman. Tabel: Advokaadibüroode osanikest juhatuse liikmed teenivad lõviosa tulust dividendidena

  16. JPRS Report, East Asia, Southeast Asia.

    Science.gov (United States)

    1988-11-16

    Countries Reported 26 Council of Ministers Decision on Petroleum Trade 26 Industrial, Commercial Banks Increase Assets 26 BIOGRAPHIC Biographic...Helmut Kohl to a press conference with foreign and Indonesian reporters at the Wisma Negara building in Jakarta on 2 October, [pas- sage omitted...IPRS-SEA-88-045 6 NOVEMBER 1988 !■■■■■ >A%1 WWMA FOREIGN BROADCAST INFORMATION SERVICE IPDG Report — C mfTMBüTION RTATSrtENJJl Approved for

  17. Forma y composición en la arquitectura deconstructivista

    OpenAIRE

    Medina Gómez, Vicente Esteban

    2011-01-01

    La arquitectura deconstructivista surge en una exposición, homónimamente titulada, que Philip Johnson y Mark Wigley organizaron en el Museo de Arte Moderno (MoMA) de Nueva York en 1988. En dicha oportunidad mostraron el trabajo de siete estudios de arquitectos estadounidenses y europeos: - Frank Owen Gehry - Daniel Libeskind - Rem Koolhaas / Office for Metropolitan Architecture -OMA- - Peter Eisenman - Zaha Hadid - Wolf Prix y Helmut Schwizinsky -Coop Himmelb(l)au- - B emard Tschumi Los comis...

  18. Untersuchung von Methoden zur ldentifikation der zeit und frequenzabhangigen Netzimpedanz (Investigation of Methods for the Identification of Time and Frequency dependent Network Impedances) Impedances

    Science.gov (United States)

    2016-10-01

    NUMBER Helmut-Schmidt-Universitat Holstenhofweg 85 22043 Hamburg Germany 11. SUPPLEMENTARY NOTES Text in German. 12a. DISTRIBUTION/AVAILABILITY...zum Gelingen dieser Arbeit beigetragen haben. Des Weiteren miichte ich mich bei meiner Familie und meinen Freunden bedanken, die mich stets...transformer windings," Proceedings of the Institution of Electrical Engineers, IEEE, vol. 113, no. 8, pp. 1387-1394, August 1966 [DPA10] Jordan, M.; Schulz

  19. Der ,Neue Mann' zwischen Familie und Beruf : Erkundungen bei Hans Fallada und Joseph Breitbach

    OpenAIRE

    Albert, Claudia

    2014-01-01

    Falladas „Kleiner Mann“ gehört zu den Erfolgstiteln der späten Weimarer Republik und darf bis heute mit uneingeschränktem Publikumsinteresse rechnen. Empathisch, realitätsnah, detailreich, aber wenig politisch engagiert, rief die Darstellung der absinkenden Mittelschicht schon in der Weimarer Republik den Vorwurf der „linken Melancholie“ hervor, der neben Fallada auch Kästner traf. Noch 1970 diente diese Kategorie dem Literaturwissenschaftler Helmut Lethen als Kampf- und Abwehrbegriff gegen e...

  20. MODERN MOVEMENT MEDIATIONS: BRAZILIAN MODERNISM AND THE IDENTITY OF POST-WAR ARCHITECTURE IN PRETORIA, SOUTH AFRICA.

    Directory of Open Access Journals (Sweden)

    Arthur Adrian Barker

    2017-08-01

    Full Text Available THE BRAZILIAN ARCHITECTURE OF OSCAR NIEMEYER INSPIRED THE DESIGN OF A NUMBER OF SOUTH AFRICAN BUILDINGS. THIS ARTICLE WILL CONTEXTUALISE MODERN MOVEMENT MEDIATIONS AND WILL HIGHLIGHT SIMILARITIES IN APPROACH TO IDENTITY, CONTEXT AND A RANGE OF EFFICIENCIES THROUGH A COMPARISON OF OSCAR NIEMEYER'S 1945 MINISTRY OF EDUCATION AND HEALTH BUILDING IN RIO DE JANEIRO AND HELMUT STAUCH'S 1952 MEAT BOARD BUILDING IN PRETORIA.

  1. Kunstiakadeemia - 85 / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1999-01-01

    28. XI tähistas Eesti Kunstiakadeemia oma 85. aastapäeva. Kunstihariduse tulevikule pühendatud paneeldiskussioonist Sakala keskuse väikeses saalis, pressikonverentsist, pidulikust aktusest. Kunstiakadeemia esimesteks audoktoriteks promoveeriti Boris Bernshtein, Kaljo Põllu, Enno Hallek, Ilja Kabakov. Auliikmeteks nimetati Mari Adamson, Leo Gens, Leili Kuldkepp, Helene Kuma, Paul Luhtein, Arseni Mölder, Evald Okas, Helmut Oruvee, Bruno Tomberg, Jaan Vares. Juubelialbumi kujundas Jüri Kaarma, ajaloolise ülevaate kirjutas Leo Gens

  2. Supporting members

    Science.gov (United States)

    Life Supporting Members L. Thomas Aldrich Thomas D. Barrow Hugh J . A. Chivers Allan V. Cox Samuel S. Goldich Pembroke J. Hart A. Ivan Johnson Helmut E. Landsberg Paolo Lanzano Murli H. Manghnani L. L. Nettleton Charles B. Officer Hyman Orlin Ned A. Ostenso Erick O. Schonstedt Waldo E. Smith Athelstan Spilhaus A. F. Spilhaus, Jr. John W. Townsend, Jr. James A. Van Allen Leonard W. Weis Charles A. Whitten J. Tuzo Wilson

  3. Modern oder Postmodern? Traditionalismus, Avantgarde oder Postavangarde?

    Directory of Open Access Journals (Sweden)

    Kostakeva Maria

    2006-01-01

    Full Text Available (nemački Mittelpunkt des Aufsatzes sind einige methodologische Probleme bei der Betrachtung der Kunst, bzw. Musik an der Schwelle der zwei Jahrhunderten. Anhang einiger Besonderheiten im Kompositionsverfahren von vier wichtigen Komponisten (György Ligeti, Alfred Schnittke, Helmut Lachenmann, Adriana Hölszky und im Licht der führenden Ideen der modernen Philosophie und Ästhetik wird versucht, die Idiomatik unserer Epoche unter Lupe zu stellen.

  4. Visit of Dr Stahl, Secretary of State, Federal Ministry for Education Science, Research and Technology, Germany, accompanied by MinDirig Dr Eschelbacher and MinR Dr Freytag

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    Visiting CERN on 19 January was Helmut Stahl, Secretary of State of the German Federal Ministry of Science, Education, Research and Technology (centre) seen here admiring prototype magnets for CERN's LHC proton collider with new President of CERN Council Hans Eschelbacher (right) and German delegate to CERN Council Arno Freytag. In the background is Dietrich Gusewell, Head of CERN's EST (Engineering Support and Technologies) Division.

  5. Guest Editorial

    Directory of Open Access Journals (Sweden)

    Jannicke Baalsrud Hauge

    2017-06-01

    Full Text Available This special issue presents five papers bringing new insights into the field of accessibility and serious games. This is a special issue from the workshops and the doctorial consortium from the 15th International Conference on Entertainment Computing 2016 hosted by professor Helmut Hlavacs at the University in Vienna, Austria (https://icec2016.cs.univie.ac.at/index.php?item=home.

  6. Five decades of the international neuropsychiatric Pula congresses (1961-2010)

    OpenAIRE

    Barac, Boško

    2010-01-01

    Summary: The International Neuropsychiatric Pula Symposia, now Congresses, have passed their five decades. The author participated at first as participant (in 1966), later as a help to the founder of the meetings, Professor Lopašić, as a Head of the “Yugoslav regional office” (from 1970), as a Kuratorium member (from 1974), as a Croatian Secretary General (1985-2007), collaborating with the Austrian Secretaries General: Gerald Grinschgl (1970-1985) and Helmut Lechner (1985-2005). ...

  7. Dynamic factor models in estimation and forecasting

    OpenAIRE

    Bystrov, Victor

    2008-01-01

    Defence date: 6 March 2008 Examining Board: Supervisor: Anindya Banerjee Second reader: Helmut Luetkepohl First made available online 2 June 2015. This thesis addresses the issue of the relative performance of dynamic factor models in finite samples in the presence of structural breaks. It extends an existing literature by considering new data sets and evaluating finite sample properties of dynamic factor models and factor-augmented VARs and VECMs in Monte Carlo exercises. C...

  8. JPRS Report Proliferation Issues

    Science.gov (United States)

    1991-11-07

    0842 GMT tories. After analysis , the scientists came to the conclu- 23 Oct 91 sion that the samples had high radioactivity. The micro- probe analysis ...Unfortunately, not less costly. We have made a We already have everything ready-the state program comprehensive analysis of these offers and concluded weighs a...projects. Investigations are currently being conducted istry, into 11 companies. into the companies H. und H. Metalform , Inwako For example, the Helmut

  9. Association of depression with disease severity in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Kim, Ki Uk; Park, Hye-Kyung; Jung, Hee Young; Ahn, Jong-Joon; Moon, Eunsoo; Kim, Yun Seong; Lee, Min Ki; Lee, Haejung

    2014-04-01

    Patients with chronic obstructive pulmonary disease (COPD), which is predicted to be the third most common cause of death worldwide by 2020, often suffer from depression, one of the most common and modifiable comorbidities of COPD. This study assessed the prevalence of depression in patients with COPD and the association of depression with disease severity. This was a multicenter, prospective cross-sectional study of 245 patients with stable COPD. Disease severity was assessed using two scales: the global initiative for chronic obstructive lung disease (GOLD) stage and BODE index. Depression was measured using the Centers for Epidemiologic Studies Depression (CES-D) scales. Data were analyzed using descriptive statistics, Spearman correlation, and multivariate logistic regression. Depression defined as a CES-D score of 24 and higher was observed in 17.6 % of patients with COPD. The prevalence of depression increased with disease severity based on the BODE quartile (r = 0.16; P = 0.014). By contrast, no difference was observed in the prevalence of depression among the severity groups using the GOLD staging system (r = - 0.01; P = 0.898). Elementary school graduates were more likely to experience depression than graduates of high school and above [odds ratio (OR) = 3.67; 95 % confidence interval (CI) 1.37-9.85] and patients in BODE quartile II were more likely to experience depression than those with BODE quartile I (OR = 2.5; 95 % CI  1.04-6.06). Depression was associated with disease severity according to the BODE quartile in patients with COPD. BODE quartile II was a significant predictor of depression. Screening patients with a high risk of depression and proactive intervention for those patients are needed.

  10. Author Details

    African Journals Online (AJOL)

    Bode-Thomas, F. Vol 30, No 1 (2003) - Articles Cardiac Arrhythmias in Children with Sickle Cell Anaemia Abstract PDF · Vol 29, No 3 (2002) - Articles Healthcare Service Auditing and Intervention in an Emergency Paediatric Unit. Abstract PDF · Vol 30, No 4 (2003) - Articles Paediatric Echocardiography in Jos University ...

  11. 367 Women in Leadership and Musical Authority in the Celestial ...

    African Journals Online (AJOL)

    operate in the background, supporting the male folk. Researchers and academics as noted in Bode Omojola's (2009) “Songs of the. King's Wives: Women, Power and Performance in the Yoruba. Public Sphere” have viewed the issue of gender discrimination from different directions and expressed their varied views on the.

  12. Rünnak vaatemängu ajastule / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2000-01-01

    Rahvusvaheline videokunsti ja uue meedia festival "Video Positive 2000" Liverpoolis üldteemal "The Other Side of Zero". Kontseptsiooni autor Steven Bode. Pikemalt sotsiaalsetest projektidest Internetis ja Iliyana Nedkova kureeritud näitusest "Spacecraft", kus oli väljas ka Mare Tralla töö "silm-vaatlusõhupall"

  13. Overexcitabilities and Giftedness Research: A Call for a Paradigm Shift

    Science.gov (United States)

    Mendaglio, Sal

    2012-01-01

    There has been an increase in publications of quantitative research studies investigating overexcitabilities (OEs) and giftedness. On one hand, increased interest in OEs bodes well for the dissemination of Dabrowski's theory of positive disintegration (TPD), from which OEs are derived. On the other hand, recent research raises concerns regarding…

  14. The Quality of Life in Hong Kong

    Science.gov (United States)

    Sing, Ming

    2009-01-01

    The AsiaBarometer of 1,000 respondents shows that Hong Kong people have a great desire for materialistic attainment, and such an emphasis on materialism bodes ill for their quality of life. Negative assessments of the public life sphere, which encompasses the natural environment, the social welfare system, and the democratic system, also detract…

  15. Pilot survey of ethnozoological utilization of vertebrates in ...

    African Journals Online (AJOL)

    A survey of some vertebrates used in traditional medical practices was carried out among the Ijebu and Ibadan people of southwestern Nigeria. Open-ended structured questionnaires were administered on 50 traders at five markets namely Oja-Oba, Bode and Oje in. Ibadan; Ita-Osu in Ijebu-Ode and Obada in Ijebu-Igbo.

  16. Bandwidth oriented proportional-integral controller design for back-to-back power converters in DFIG wind turbine system

    DEFF Research Database (Denmark)

    Zhou, Dao; Blaabjerg, Frede

    2017-01-01

    /power. This paper focuses on the modelling of power converters and the parameters design of PI controller. According to the Bode plots, the relationship among the switching frequency, inner loop bandwidth, and outer loop bandwidth can be found. At least one tenth difference between them is necessary for the sake...

  17. Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients

    DEFF Research Database (Denmark)

    Kerstjens, Huib A; Bjermer, Leif; Eriksson, Leif

    2010-01-01

    ). There was no statistically significant difference between AZD4818 and placebo in change from baseline to endpoint for FEV(1) (AZD4818-placebo: 0.026L, p=0.69), morning PEF (-6L/min, p=0.23), or other lung function measures. There was no difference between treatment groups in the 6-min walk test, MMRC dyspnoea index, BODE...

  18. Gauss, Carl Friedrich (1777-1855)

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    Scientist, born in Brunswick (now in Germany), worked in mathematics and physics including number theory, analysis, differential geometry, geodesy, magnetism, astronomy and optics. A child prodigy, at an early age Gauss independently discovered BODE's law, the binomial theorem and the prime number theorem, as well as the method of the construction of a regular 17-gon by ruler and compasses. In 18...

  19. African Journal of Paediatric Surgery: Editorial Policies

    African Journals Online (AJOL)

    M A Bankole (Nigeria) A B Van As (South Africa) F Abantanga (Ghana) C O Bode (Nigeria) J M Kyambi (Kenya) B Sani (Cote d'Voire) Overseas Editorial Consultants C J Stolar (New York) H Ford (Pittsburgh) B Nwomeh(Columbus) N A Ajayi (London) D Llyod (Liverpool) F Rescorla (Indianapolis, USA) Boix Ochoa (Spain)

  20. Variation in foraging activity of Acanthochitona garnoti (Mollusca ...

    African Journals Online (AJOL)

    Charles Griffiths are thanked for valuable comments on a draft of this paper. References. BODE, A. I <}S9. Production of the intertidal chiton Acal1lllOchitona ainita within a community of Corollina elongata (Rhodophyta). J. Moll. Stud 55: 37-44. BRANCH. G.M. 1981. Tho biology of limpets: physical factors, energy flow and ...

  1. Frequency-Domain Thermal Modelling and Characterization of Power Semiconductor Devices

    DEFF Research Database (Denmark)

    Ma, Ke; He, Ning; Liserre, Marco

    2016-01-01

    -based thermal networks are explained from a point of view of frequency domain. Based on the discovery, a more advanced thermal model developed in the frequency domain is proposed, which can be easily established by characterizing the slope variation from the bode diagram of the typically used Foster thermal...

  2. Exponential law as a more compatible model to describe orbits of planetary systems

    Directory of Open Access Journals (Sweden)

    M Saeedi

    2012-12-01

    Full Text Available   According to the Titus-Bode law, orbits of planets in the solar system obey a geometric progression. Many investigations have been launched to improve this law. In this paper, we apply square and exponential models to planets of solar system, moons of planets, and some extra solar systems, and compare them with each other.

  3. Building New Identities in Teacher Preparation for Inclusive Education in Ghana

    Science.gov (United States)

    Agbenyega, Joseph S.; Deku, Prosper K.

    2011-01-01

    "We want our classrooms to be just and caring, full of various conceptions of the good. We want them to be articulate, with the dialogue involving as many persons as possible, opening to one another, opening to the world" (Greene 1993 as cited in Nieto & Bode, 2008). These words sum up inclusive education as a multifaceted practice…

  4. Author Details

    African Journals Online (AJOL)

    Bode-Thomas, F. Vol 3, No 1 (2016) - Articles Enuresis among primary school children in Jos, Plateau State Abstract. ISSN: 2354-4325. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... Journal Quality · for Researchers · for Journals · for Authors ...

  5. Browse Title Index

    African Journals Online (AJOL)

    Items 101 - 150 of 1605 ... C.O. Bode, E.U. Onifade, A.E. Ohwovoride. Vol 17, No 6 (2014), An ectopic hamartomatous thymoma ... Vol 12, No 4 (2009), Aortic arch diameter and its significance in the clinical evaluation of cardiac and aortic enlargements, Abstract PDF. G.E Anyanwu, K.K Agwuna. Vol 19, No 1 (2016), Apical ...

  6. Assessment of selected cooking characteristics of prime starch and ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-08-04

    Aug 4, 2008 ... mandatory to enhance edibility of cassava fibres. This is because cooking step creates the physical properties ne-. *Corresponding author. E-mail: daramola_bode@yahoo.co.uk. cessary for the development of texture in food products. (Caldwell et al., 2000). Characterization of cooking properties of ...

  7. Hearings Before the Select Committee on Nutrition and Human Needs of the United States Senate, Ninety-Second Congress, First Session on Nutrition and Human Needs. Part 4--Implementation, 1970 Amendments to the National School Lunch Act. Hearings Held Washington, D.C., May 3-4, 1971.

    Science.gov (United States)

    Congress of the U.S., Washington, DC. Senate Select Committee on Nutrition and Human Needs.

    In trying to solve the problem of hunger in the classroom, the Senate Select Committee on Nutrition and Human Needs heard the testimony of many witnesses, among whom were: Miss Barbara Bode, Program Director, The Children's Foundation; Miss Barbara Hockert, President, Burlington Ad Hoc Committee on School Lunches; and, Mrs. Joseph H. Young,…

  8. African Journal of Anaesthesia and Intensive Care: Submissions

    African Journals Online (AJOL)

    1) For journal articles, give surname and initials of author, article title, name of journal, year of publication, volume number and first and last pages. E.g (i) Sanusi AA, Soyannwo OA, Amanor-Boadu SD. Intra-operative cardiac arrest. West Afr J Med 2001; 20: 192-195. (ii) Merah NA, ffoulkes-Crabbe DJO, Kushimo OT, Bode ...

  9. Predictive properties of different multidimensional staging systems in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Oga T

    2011-10-01

    Full Text Available Toru Oga1, Mitsuhiro Tsukino2, Takashi Hajiro3, Akihiko Ikeda4, Koichi Nishimura5 1Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 2Department of Respiratory Medicine, Hikone Municipal Hospital, Hikone, Japan; 3Department of Respiratory Medicine, Tenri Hospital, Tenri, Japan; 4Department of Respiratory Medicine, Nishi-Kobe Medical Center, Kobe, Japan; 5Department of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan Background: Chronic obstructive pulmonary disease (COPD is considered to be a respiratory disease with systemic manifestations. Some multidimensional staging systems, not based solely on the level of airflow limitation, have been developed; however, these systems have rarely been compared. Methods: We previously recruited 150 male outpatients with COPD for an analysis of factors related to mortality. For this report, we examined the discriminative and prognostic predictive properties of three COPD multidimensional measurements. These indices were the modified BODE (mBODE, which includes body mass index, airflow obstruction, dyspnea, and exercise capacity; the ADO, composed of age, dyspnea, and airflow obstruction; and the modified DOSE (mDOSE, comprising dyspnea, airflow obstruction, smoking status, and exacerbation frequency. Results: Among these indices, the frequency distribution of the mBODE index was the most widely and normally distributed. Univariate Cox proportional hazards analyses revealed that the scores on three indices were significantly predictive of 5-year mortality of COPD (P < 0.001. The scores on the mBODE and ADO indices were more significantly predictive of mortality than forced expiratory volume in 1 second, the Medical Research Council dyspnea score, and the St. George's Respiratory Questionnaire total score. However, peak oxygen uptake on progressive cycle ergometry was more significantly related to mortality than the scores on

  10. Klaasarhitektuur Berliinis / Pille Nagel

    Index Scriptorium Estoniae

    Nagel, Pille

    2004-01-01

    Helmut Jahni loodud Sony keskus (1993...2000) ja Kranzlereck (1992...2000), Potsdami platsi jaam (bürood Hilmer & Sattler und Albrecht, Modersohn & Freiesleben ja Hermann + Öttl, 1997...2000), intelligentse klaasfassaadiga Debise büroohoone (Renzo Piano koostöös Critoph Kohlbeckeriga, 1991...1997) ja GSW büroohoone (Sauerbruch Hutton Architekten, 1995...1999), topeltfassaadiga Nordrhein-Westfaleni liidumaade esindushoone (Petzinka Pink Architekten, 2000/2001), Riigipäevahoone klaaskuppel (Foster ja Partnerid, 1992...1999), klaaskatusega DZ-Pank (Frank Owen Gehry, 1996...1999)

  11. Recent advances in remote sensing and geoinformation processing for land degradation assessment

    CERN Document Server

    Roeder, Achim

    2009-01-01

    Acknowledgements Contributors Achim Röder & Joachim Hill, Remote sensing and geoinformation processing in land degradation assessment-an introduction Part 1 Setting the scene: principles in remote sensing and spatial scene modelling for land degradation assessmentEric F. Lambin, Helmut Geist, James F. Reynolds & D. Mark Stafford-Smith, Coupled human-environment system approaches to desertification: Linking people to pixels Susan L. Ustin, Alacia Palacios-Orueta, Michael L. Whiting, Stéphane Jacquemoud & Lin Li, Remote sensing based assessm

  12. Elamine gaasimahutites : nelja ajaloolise gasomeetri ümberehitus Viinis / Reinhard Seiss

    Index Scriptorium Estoniae

    Seiss, Reinhard

    2005-01-01

    Theodor Hermanni plaanide järgi 1896-1899 ehitatud nelja muinsuskaitse all oleva gasomeetri ümberehitusest aastail 1998-2001. Autorid Jean Nouvel, Coop Himmelb(l)au (arhitektid Wolf Prix, Helmut Swiczinsky), Manfred Wehdorn ja Wilhelm Holzbauer. Gasomeertrid on maapealsel korrusel ühendatud jalakäijate ala ja poekompleksiga Shopping Mall, hoonete ülemistes osades on bürood ja korterid, maa-alusel korrusel garaahid. Pleasuredome'i arhitekt Rüdiger Lainer. Linnaosa arendamise kavast. Ill.: 1 joonis, 7 värv. fotot

  13. Rethinking National Security

    Science.gov (United States)

    1990-10-01

    J00 1984) Jones, Rodney W., ed. Sl Nuclear Forces and . Zcurty Policy: Threats A Pn tialXn Conliic I th idl 4 &&.4 +.,tjLd South Asia . Lexington, MA...MkkAM, Zreetszi. and W.LaAX. Boulder: Lynn* Rlenner. 1909. (UA 23 .3275 1000) Schmidt. Helmut. & Grand S gly for the& M : TAI Anachronism 2f Nalional...Organizational Histor SL UA Natoa fnayL± CnmAsLA dMr.Ln f" Xon n d" Johnson . Washington: National Security Council. 106s. (Gov Does Prix 3.2:Or 3) Smith. Theresa

  14. Break-glass handling exceptional situations in access control

    CERN Document Server

    Petritsch, Helmut

    2014-01-01

    Helmut Petritsch describes the first holistic approach to Break-Glass which covers the whole life-cycle: from access control modeling (pre-access), to logging the security-relevant system state during Break-Glass accesses (at-access), and the automated analysis of Break-Glass accesses (post-access). Break-Glass allows users to override security restrictions in exceptional situations. While several Break-Glass models specific to given access control models have already been discussed in research (e.g., extending RBAC with Break-Glass), the author introduces a generic Break-Glass model. The pres

  15. Reseñas de libros: mayo de 1964

    Directory of Open Access Journals (Sweden)

    Antonio Panesso Robledo

    1964-05-01

    Full Text Available El documento presenta las reseñas de los siguientes títulos: Eric J. Hobsbawm. Las Revoluciones Burguesas. (The Age of Revolutions Gabriel García Marquez. Notas sobre la Mala Hora. Montaña, Antonio: Cuando termine la lluvia. Bogotá, Ediciones Tecer Mundo, 1963. 194 págs. Beinhauer Werner: El español coloquial. Madrid, Editorial Gredos, 1963. 445 págs. Hatzfeld, Helmut: Estudios sobre el barroco. Madrid, Editorial Gredos, 1964. 487 págs.

  16. The Burden of Trafalgar: Decisive Battle and Naval Strategic Expectations on the Eve of the First World War

    Science.gov (United States)

    1993-10-01

    enemies’ motive power, capture, risk, destroy.,,6 But what exactly was a victorious bataille royaZe to decide? What were its aims, and how did one tell a...Empire (London: George Bell and Sons, 1 895) , p. 47 . 53 . Helmut Pemsel, A History of War at Sea, tra ns. Maj . D.G . Smith (Annapolis: Naval I...1 803- 1 4 (London : George Allen & Unwin Ltd. , 1 973) , p. 1 4 . The author’s data are taken from Edouard D esbriere’s Projects et Tentilles

  17. Dr. von Braun and Army Ballistics Missile Agency (ABMA) Group

    Science.gov (United States)

    1959-01-01

    This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

  18. CERN safety expert receives international award

    CERN Multimedia

    2005-01-01

    On 18 December 2004, the President of the Swiss Electro-technical Committee, Martin Reichle (left), presented the award to Helmut Schönbacher. Helmut Schönbacher, of the Safety Commission at CERN, has received, the "1906 Award" of the International Electrotechnical Commission (IEC) for his standardisation work on the influence of ionizing radiation on insulating materials. From 1986 until 2004, Schönbacher was leader of a working group on radiation composed of internationally recognised experts. It edited standards of the IEC 60544 series on the determination of the effects of ionizing radiation on electrical insulating materials. The working group also edited three IEC Technical Reports on the determination of long-term radiation ageing in polymers. This standardisation work and long-term experience from CERN on the radiation ageing of materials also contributed to research coordination programmes of the International Atomic Energy Agency (IAEA). From 1968 until 1988, Schönbacher was a member of the Rad...

  19. Editorial: Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Andreas Zick

    2015-07-01

    Full Text Available Editorial 8(2 We are pleased to present issue 8 (2. The focus section is edited by Helmut Thome (University of Halle-Wittenberg, Germany and Steven F. Messner (University at Albany, United States, and focuses on methodological constraints, options, and solutions in longitudinal research on criminal violence. We are honored that Helmut Thome, Steven Messner, and the contributors offer their scientific knowledge and evidence in the interests of gaining a deeper understanding of one of the most promising methodological approaches in conflict and violence research, i.e. longitudinal data analyses. Sincere thanks to the editors and authors for opening up the potential of this specific kind of research for advances to better assess and understand criminal violence in a long term perspective. We hope this issue will be discussed and quoted in the interdisciplinary community of researchers. The open section again fulfills its aim to foster contributions on diverse topics in the field of conflict and violence, starting with an analysis of Southeast Asian media reception of the Israeli/Palestine conflict. The second paper shows how social cohesion activities have the potential to change disparaging attitudes in Cyprus. The third and final contribution examines teen dating violence in Switzerland from various angles.

  20. Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology.

    Science.gov (United States)

    Taniguchi, Naoyuki; Kizuka, Yasuhiko; Takamatsu, Shinji; Miyoshi, Eiji; Gao, Congxiao; Suzuki, Keiichiro; Kitazume, Shinobu; Ohtsubo, Kazuaki

    2016-04-01

    Reduction-oxidation (redox) response is one of the most important biological phenomena. The concept introduced by Helmut Sies encouraged many researchers to examine oxidative stress under pathophysiological conditions. Our group has been interested in redox regulation under oxidative stress as well as glycobiology in relation to disease. Current studies by our group and other groups indicate that functional and structural changes of glycans are regulated by redox responses resulting from the generation of reactive oxygen species (ROS) or reactive nitrogen species (RNS) in various diseases including cancer, diabetes, neurodegenerative disease such as Parkinson disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS), and chronic obstructive pulmonary disease (COPD), even though very few investigators appear to be aware of these facts. Here we propose that the field "glyco-redox" will open the door to a more comprehensive understanding of the mechanism associated with diseases in relation to glycan changes under oxidative stress. A tight link between structural and functional changes of glycans and redox system under oxidative stress will lead to the recognition and interest of these aspects by many scientists. Helmut's contribution in this field facilitated our future perspectives in glycobiology. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. DESY greets CERN

    CERN Multimedia

    Helmut Dosch, Chairman of the DESY Board of Directors, continues the series of occasional exchanges between CERN and other laboratories world-wide. As part of this exchange, CERN Director-General Rolf Heuer wrote a message in DESY inForm. Helmut Dosch took over from Albrecht Wagner in March 2009. You may think that the connections between CERN and DESY are obvious – particle physics labs with record-breaking accelerators and users from all around the world trying to solve mankind’s great mysteries. We even exchanged a few Directors. But did you know that there are similarities that are much closer to home – for example that both labs have names for their staff in the host language that are untranslatable into English? You are CERNoises and CERNois, we are DESYanerinnen and DESYaner. And in the end it’s the people it all comes down to. We at DESY admire the resourcefulness, enthusiasm, dedication and perseverance with which you at CERN have designed, built, started ...

  2. How to Dispel the Fog over the Past? Post-War Children, Their Fathers-Soldiers and Consequences of the Second World War

    Directory of Open Access Journals (Sweden)

    Ekaterina S. Lyubomirova

    2016-01-01

    Full Text Available The article is devoted to the new aspects in the study of the history of post-war Germany, revealed in the book written by Sabine Bode «Post-war children - born in the 1950s, and their fathers-soldiers». It discusses the contribution made by Bode in the study of mental and psycho-emotional consequences of the Second World War and the «exclusion of the past», which is reflected in the fate of the post-war children and continues to have an impact on the socio-political life of the Federal Republic of Germany up to the present day. Nevertheless the article criticizes an excessive preoccupation of the monograph with the descriptions of the individual biographies to the detriment of analysis.

  3. Potential consequences for stable chronic obstructive pulmonary disease patients who do not get the recommended minimum daily amount of physical activity.

    Science.gov (United States)

    Pitta, Fabio; Troosters, Thierry; Probst, Vanessa S; Lucas, Sarah; Decramer, Marc; Gosselink, Rik

    2006-01-01

    The present study attempted to determine whether patients with chronic obstructive pulmonary disease (COPD) get the minimum daily amount of physical activity recommended in the guidelines established by the American College of Sports Medicine (ACSM), as well as to characterize the consequences of noncompliance with those guidelines. This study involved 23 patients (median age: 61--range, 59-69 years; FEV1: 39% of predicted--range, 34-53%; BMI: 24 kg/m(2)--range, 21-27 kg/m(2)). The following parameters were evaluated: daily physical activity (DynaPort activity monitor); pulmonary function; muscle force; exercise tolerance; quality of life; functional status; and various indices of disease severity (GOLD, BODE and MRC). Based on compliance with the guidelines (minimum of 30 minutes of walking per day), 12 patients were considered "physically active", and 11 were considered "physically inactive". No significant differences were observed between the two groups in terms of age, gender, BMI, muscle force, ventilatory reserve, hyperinflation or quality of life. The inactive group presented more impaired pulmonary function and lower exercise tolerance, as well as lower MRC and BODE scores (p guidelines, both presenting a specificity of 0.83, compared with 0.50 for the GOLD index. The BODE index score increased significantly with each day of inactivity. A large number of COPD patients do not walk more than 30 minutes per day and are therefore not getting the minimum daily amount of physical activity recommended by the ACSM. Inactivity correlates with a higher mortality rate. The MRC and BODE indices proved superior to the GOLD index in predicting whether patients are physically inactive in their daily lives.

  4. Comparison of the 2017 and 2015 Global Initiative for Chronic Obstructive Lung Disease Reports. Impact on Grouping and Outcomes.

    Science.gov (United States)

    Cabrera López, Carlos; Casanova Macario, Ciro; Marín Trigo, José María; de-Torres, Juan P; Sicilia Torres, Rebeca; González, Jesús María; Polverino, Francesca; Divo, Miguel; Pinto Plata, Víctor; Zulueta, Javier J; Celli, Bartolomé

    2018-02-15

    The Global Initiative for Chronic Obstructive Lung Disease (GOLD) document has modified the grading system directing pharmacotherapy, but how this relates to the previous one from 2015 and to comorbidities, hospitalizations, and mortality risk is unknown. The aim of this study was to evaluate the changes in the GOLD groups from 2015 to 2017 and to assess the impact on severity, comorbidities, and mortality within each group. We prospectively enrolled and followed, for a mean of 5 years, 819 patients with chronic obstructive pulmonary disease (84% male) in clinics in Spain and the United States. We determined anthropometrics, lung function (FEV 1 %), dyspnea score (modified Medical Research Council scale), ambulatory and hospital exacerbations, and the body mass index, obstruction, dyspnea, and exercise capacity (BODE) and Charlson indexes. We classified patients by the 2015 and 2017 GOLD ABCD system, and compared the differential realignment of the same patients. We related the effect of the reclassification in BODE and Charlson distribution as well as chronic obstructive pulmonary disease and all-cause mortality between the two classifications. Compared with 2015, the 2017 grading decreased by half the proportion of patients in groups C and D (20.5% vs. 11.2% and 24.6% vs. 12.9%; P < 0.001). The distribution of Charlson also changed, whereas group D was higher than B in 2015, they become similar in the 2017 system. In 2017, the BODE index and risk of death were higher in B and D than in A and C. The mortality risk was better predicted by the 2015 than the 2017 system. Compared with 2015, the GOLD ABCD 2017 classification significantly shifts patients from grades C and D to categories A and B. The new grading system equalizes the Charlson comorbidity score in all groups and minimizes the differences in BODE between groups B and D, making the risk of death similar between them.

  5. Sol–gel synthesis and photoluminescence of CaTi1–x Zrx O3 :Pr ...

    Indian Academy of Sciences (India)

    Administrator

    Res. Bull. 41 674. Blasse G and Corsmit A F 1973 J. Solid State Chem. 6 513. Bode J H G and Van Oosterhout A B 1975 J. Lumin. 10 237. Cavalcante L S, Simőes A Z, Santos L P S, Santos M R M C,. Longo E and Varela J A 2006 J. Solid State Chem. 179. 3739. Cavalcante L S, Gurgel M F C, Simőes A Z, Longo E, Varela.

  6. Morphology and tectonics of the Mid-Atlantic Ridge, 7°–12°S

    OpenAIRE

    Bruguier, N.J.; Minshull, T.A.; Brozena, J. M.

    2003-01-01

    We present swath bathymetric, gravity, and magnetic data from the Mid-Atlantic Ridge between the Ascension and the Bode Verde fracture zones, where significant ridge–hot spot interaction has been inferred. The ridge axis in this region may be divided into four segments. The central two segments exhibit rifted axial highs, while the northernmost and southernmost segments have deep rift valleys typical of slow-spreading mid-ocean ridges. Bathymetric and magnetic data indicate that both central ...

  7. Original Article

    African Journals Online (AJOL)

    MR. USER

    Journal of Accident Surgery 1987; 18: 93-95. 4. Hiram, C:, Polk Jr, and Lewis M. Flint. Intra- abdominal injuries in poly trauma. World J. Surg. 1983; 7 pp. 5. Alexander Williams, J. Laparoscopy in. Abdominal Trauma: Injury: International Journal of the Care of the Injured. 1994; 25: 585-586. 6. Schurink G.W.H, Bode P.J, Van ...

  8. Disease: H01295 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available t across the blood brain barrier via the choroid plexus. It has been reported that mutations in FOLR1 cause this disea...ction. Neurodegenerative disease hsa04144(2348) Endocytosis FOLR1 [HSA:2348] [KO:..., Bode H, Debatin KM, Opladen T, Schwarz K Congenital null mutations of the FOLR1 gene: a progressive neurologic disease and its treatment. Neurology 73:2127-9 (2009) ...

  9. Psychosocial Development in Middle Childhood and Early Adolescence : A Handbook for Icehearts’ Educators

    OpenAIRE

    Bode, Christian

    2015-01-01

    Christian Bode. Psychosocial Development in Middle Childhood and Early Adolescence: A Handbook for Icehearts’ Educators. Helsinki 2015, 157 pages plus appendices. Diaconia University of Applied Sciences, Helsinki. Degree Programme in Social Services. The aim of this study was to develop a handbook for Icehearts’ educators, a Finnish third sector organization for children and youth work, and for other educators and caregivers. The focus lies on major psychosocial development phases during ...

  10. Research of Active Power Filter Modeling with Grid Impedance in Feedback Linearization and Quasi-Sliding Mode Control

    OpenAIRE

    Shi, Zeyu; Wang, Yingpin; Xie, Yunxiang; Li, Lanfang; Xu, Xiaogang

    2017-01-01

    Active power filter (APF) is the most popular device in regulating power quality issues. Currently, most literatures ignored the impact of grid impedance and assumed the load voltage is ideal, which had not described the system accurately. In addition, the controllers applied PI control; thus it is hard to improve the compensation quality. This paper establishes a precise model which consists of APF, load, and grid impedance. The Bode diagram of traditional simplified model is obviously diffe...

  11. Durable Hybrid Coatings Annual Performance Report (2009)

    Science.gov (United States)

    2009-10-01

    was done using a conventional curing system comprised of an H-bulb and conveyor belt . The UV intensity and UV-A dose measured using a dosimeter was...temperature to harden. The topcoat was applied with the sensor embedded between the layers. The experimental apparatus included a Perspex cylinder...representations of the spectra are shown in Figure 5 with immersion time as a parameter for the topcoat/primer system . The Bode magnitude plot for day 1 included

  12. Recent progress in organic electronics and photonics: A perspective on the future of organic devices

    KAUST Repository

    Bredas, Jean-Luc

    2016-02-25

    The fields of organic electronics and photonics have witnessed remarkable advances over the past few years. This progress bodes well for the increased utilization of organic materials as the active layers in devices for applications as diverse as light-emitting diodes, field-effect transistors, solar cells, or all-optical switches. In the present document, we choose to focus the discussion on organic all-optical switching applications. © 2015 The Japan Society of Applied Physics.

  13. Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery

    Directory of Open Access Journals (Sweden)

    DeMeo Dawn L

    2007-08-01

    Full Text Available Abstract Background In the National Emphysema Treatment Trial (NETT, marked variability in response to lung volume reduction surgery (LVRS was observed. We sought to identify genetic differences which may explain some of this variability. Methods In 203 subjects from the NETT Genetics Ancillary Study, four outcome measures were used to define response to LVRS at six months: modified BODE index, post-bronchodilator FEV1, maximum work achieved on a cardiopulmonary exercise test, and University of California, San Diego shortness of breath questionnaire. Sixty-four single nucleotide polymorphisms (SNPs were genotyped in five genes previously shown to be associated with chronic obstructive pulmonary disease susceptibility, exercise capacity, or emphysema distribution. Results A SNP upstream from glutathione S-transferase pi (GSTP1; p = 0.003 and a coding SNP in microsomal epoxide hydrolase (EPHX1; p = 0.02 were each associated with change in BODE score. These effects appeared to be strongest in patients in the non-upper lobe predominant, low exercise subgroup. A promoter SNP in EPHX1 was associated with change in BODE score (p = 0.008, with the strongest effects in patients with upper lobe predominant emphysema and low exercise capacity. One additional SNP in GSTP1 and three additional SNPs in EPHX1 were associated (p Conclusion Genetic variants in GSTP1 and EPHX1, two genes encoding xenobiotic metabolizing enzymes, were predictive of response to LVRS. These polymorphisms may identify patients most likely to benefit from LVRS.

  14. Intelligent Engine Systems: Adaptive Control

    Science.gov (United States)

    Gibson, Nathan

    2008-01-01

    We have studied the application of the baseline Model Predictive Control (MPC) algorithm to the control of main fuel flow rate (WF36), variable bleed valve (AE24) and variable stator vane (STP25) control of a simulated high-bypass turbofan engine. Using reference trajectories for thrust and turbine inlet temperature (T41) generated by a simulated new engine, we have examined MPC for tracking these two reference outputs while controlling a deteriorated engine. We have examined the results of MPC control for six different transients: two idle-to-takeoff transients at sea level static (SLS) conditions, one takeoff-to-idle transient at SLS, a Bode power command and reverse Bode power command at 20,000 ft/Mach 0.5, and a reverse Bode transient at 35,000 ft/Mach 0.84. For all cases, our primary focus was on the computational effort required by MPC for varying MPC update rates, control horizons, and prediction horizons. We have also considered the effects of these MPC parameters on the performance of the control, with special emphasis on the thrust tracking error, the peak T41, and the sizes of violations of the constraints on the problem, primarily the booster stall margin limit, which for most cases is the lone constraint that is violated with any frequency.

  15. Possíveis conseqüências de não se atingir a mínima atividade física diária recomendada em pacientes com doença pulmonar obstrutiva cronica estável Potential consequences for stable chronic obstructive pulmonary disease patients who do not get the recommended minimum daily amount of physical activity

    Directory of Open Access Journals (Sweden)

    Fabio Pitta

    2006-08-01

    Full Text Available OBJETIVO: O presente estudo investigou se pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC atingem a mínima atividade física recomendada pelos guidelines do American College of Sports Medicine (ACSM, assim como as consequências da não-aderência a esses guidelines. MÉTODOS: Atividade física na vida diária (DynaPort activity monitor, função pulmonar, força muscular, capacidade de exercício, qualidade de vida, estado funcional e diferentes índices de severidade (GOLD, BODE, MRC foram avaliados em 23 pacientes (61[59-69] anos; VEF1 39[34-53]%predito; IMC 24[21-27]kg/m²; mediana [intervalo interquartílico 25-75%]. RESULTADOS: De acordo com a aderência aos guidelines (andar no mínimo 30 minutos todo dia, 12 pacientes foram considerados "fisicamente ativos", e 11 "fisicamente inativos". Não foram observadas diferenças significativas entre os dois grupos em termos de idade, sexo, composição corporal, força muscular, reserva ventilatória, hiperinsuflação e qualidade de vida. O grupo inativo tinha pior função pulmonar, capacidade de exercício, MRC e BODE (pOBJECTIVE: The present study attempted to determine whether patients with chronic obstructive pulmonary disease (COPD get the minimum daily amount of physical activity recommended in the guidelines established by the American College of Sports Medicine (ACSM, as well as to characterize the consequences of noncompliance with those guidelines. METHODS: This study involved 23 patients (median age: 61 - range, 59-69 years; FEV1: 39% of predicted - range, 34-53%; BMI: 24 kg/m² - range, 21-27 kg/m². The following parameters were evaluated: daily physical activity (DynaPort activity monitor; pulmonary function; muscle force; exercise tolerance; quality of life; functional status; and various indices of disease severity (GOLD, BODE and MRC. RESULTS: Based on compliance with the guidelines (minimum of 30 minutes of walking per day, 12 patients were considered "physically

  16. Las últimas elecciones de la RDA. La puerta abierta hacia la reunificación alemana

    Directory of Open Access Journals (Sweden)

    Félix Gil Feito

    2012-10-01

    Full Text Available Las últimas elecciones celebradas el 18 de marzo de 1990 en la República Democrática Alemana (RDA fueron sin lugar a dudas una de las premisas fundamentales para que la Reunificación se produjera unos meses más tarde. Fundamental porque como reconocía el  propio Canciller de la República Federal Alemana (RFA, Helmut Kohl, era condición sine qua non que la RDA tuviera un régimen plenamente democrático con unas elecciones en las que todos los partidos políticos partieran con las mismas posibilidades. Sin que esto se produjera, las negociaciones que implicaban la ayuda económica necesaria para el bienestar de los ciudadanos del Este, así como avanzar y encaminar definitivamente la Reunificación con la formación de un nuevo gobierno en la RDA que sustituyera al SED después de cuarenta años de gobierno, la Reunificación de las dos Alemanias no hubiera llegado a fructificar nunca. Palabras clave: Reunificación alemana, elecciones, RDA , Helmut Kohl. _______________________Abstract:The last elections held on March 18, 1990 in the German Democratic Republic were without doubt one of the fundamental premises for the Reunification took place some months later. Critical because as acknowledged by the Chancellor of the FRG, Helmut Kohl, was a sine qua non that the GDR had a fully democratic regime with an election in which all political parties started with the same possibilities. Not that this should occur, the negotiations involving the financial support necessary for the welfare of the citizens of the East, and definitely the route ahead and Reunification with the formation of a new government in the GDR to replace the SED after forty years of government, the Reunification of the two Germanys had not come to fruition before.Keywords: German Reunification, election, RDA, Helmuth Kohl. 

  17. Les publications officielles du Club alpin austro-allemand (DÖAV et du DAV chilien depuis leurs créations jusqu’à aujourd’hui

    Directory of Open Access Journals (Sweden)

    Michel Mestre

    2010-05-01

    Full Text Available J’ai déjà eu l’occasion à au moins deux reprises de parler des publications du DÖAV et je ne voudrais pas reprendre tels quels ces éléments d’information, d’autant plus qu’existe une étude de synthèse, celle de Helmut Zebhauser, qui est fort bien documentée : il me paraît donc inutile de refaire ce travail, le résumer suffira ici. En revanche il était bon de donner un aperçu des publications des clubs germanophones depuis la fin de la Seconde Guerre mondiale, objet de la deuxième partie. Enfi...

  18. The Impact of Dealing with the Late Effects of National Socialist Terror on West German Psychiatric Care.

    Science.gov (United States)

    Söhner, Felicitas; Baader, Gerhard

    2017-11-21

    Health damages and the late effects of NS trauma were largely ignored in German-speaking countries. This paper describes how dealing with the late effects of Nazi terror influenced post-war psychiatry in West Germany and thus the development of the psychiatric reform. As part of a greater overview study of the impulses and framework conditions of the reform-orientated development of post-war psychiatry in West Germany, this analysis is based on a thorough literary and documentary analysis. The sources show that publications by Helmut Paul and Herberg [81] as well as Baeyer et al. [12] can be considered as remarkable milestones. The awareness of psychological late effects of NS persecution was only reluctantly taken up by the scientific community. Nevertheless, this discussion was an essential component of the reform-orientated psychiatry in West Germany in the late 1960s to 1970s.

  19. Origins of the tactical nuclear weapons modernization program: 1969-1979

    Energy Technology Data Exchange (ETDEWEB)

    Yaffe, M.D.

    1991-01-01

    On December 12, 1979 NATO decided to deploy new long-range theater nuclear forces. This marked the first major change in NATO's nuclear stockpile since the adoption of the flexible-response strategy in 1967. The decision was controversial inasmuch as the Allies disagreed on the fundamental role of nuclear weapons in this strategy and, thereby, the types and number of weapons required for an effective deterrent posture. Thus, the decision is often described as purely politically motivated, in which the Americans reluctantly acquiesced to a European initiative for long-range weapons, prominently expressed by West German Chancellor Helmut Schmidt in 1977. Recently declassified US government documents reveal, however, that long-range missiles were part of a long-term comprehensive nuclear-modernization program conceived in the Pentagon during the period of 1973 through 1975, and presented to skeptical European elites who favored arms-control negotiations over costly new deployments.

  20. Golden Jubilee photos: The first experiments

    CERN Document Server

    2004-01-01

    A year after the commissioning of the Synchrocyclotron (SC), the first experiments were already starting to bear fruit. In July 1958, Tito Fazzini, Giuseppe Fidecaro, Alec Merrison, Helmut Paul and Alvin Tollestrup produced conclusive evidence that approximately one pion in ten thousand decayed into an electron and a neutrino, as predicted by the weak interaction theory. This, the first of CERN's great discoveries, effectively put an end to the controversy that had been raging at the time. A few years later, Giuseppe Fidecaro began a collaboration at CERN with his wife Maria. In the image, Giuseppe and Maria Fidecaro in 1963, surrounded by spark chambers, inside the detector for the experiment on the decay of the rho meson into a pi meson and a photon.

  1. Elections to the Senior Staff Advisory Committee ('The Nine') 2006

    CERN Multimedia

    Sue Foffano

    2006-01-01

    The electronic voting procedure for the Senior Staff Advisory Committee ('The Nine') was closed on Friday 2 June. Of the 462 Senior Staff members eligible to vote, 291 voted and 5 abstained. The results are as follows: Electoral Group 2 Name Department Votes BURKHARDT Helmut AB 45 MARQUINA Miguel IT 45 MARTENS Reinoud IT 66 MESS Karl Hubert AT 48 PONCET Alain AT 44 SCHMICKLER Hermann AB 61 SILARI Marco SC 39 TSESMELIS Emmanuel TS 101 WILDNER Elena AT 62 Electoral Group 5a Name Department Votes GILDEMYN Pierre HR 42 SAINT-VITEUX Jean-Marc HR 39 UNNERVIK Anders FI 139 Reinoud Martens and Emmanuel Tsesmelis are therefore elected in Group 2, and Anders Unnervik is elected in Group 5a. Their mandate is from July 2006-June 2009. The committee now consists of these newly-elected members together with Philippe Charpentier, Daniel Froidevaux, Monica Pepe-Altarelli, Thomas Pettersson, Rudiger Schmidt and Andreas Schopper. Sue Foffano - Pollin...

  2. Bibliografía

    Directory of Open Access Journals (Sweden)

    Revista Chasqui

    2015-01-01

    Full Text Available “Cine venezolano, largometreajes”, Rodolfo Izaguirre, Fondo Editorial Cinemateca Nacional, Fondo de Fometno Cinematográfico, Caracas, 1983; El cine en la república Federal de Alemania, El nuevo cine alemán, origen, situación actual, Manual, Hans Funther Pflaum/Hans Helmut Prinzler, Inter Nationes Bonn, 1983; Comunicación visual y escuela “Aspectos pedagógicos del lenguaje visual, Lucia Lazotti Fontana. Colección Punto y línea, Editorial Gustavo Gili S.A., Barcelona, 1983; Cine, censura y exilio en América Latina, Alfonso Gumucio-Dagron, CIMCA, La Paz – Bolivia 1984.

  3. Electric power plant technology. Generators, transformers, auxiliary installations, protective systems. Lecture notes. 5. rev. ed.; Elektrische Kraftwerkstechnik. Generatoren, Transformatoren, Eigenbedarfsanlagen, Schutzeinrichtungen. Vorlesungsskript

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Ulrich

    2009-07-01

    The lecture series on electric power plant engineering was initiated in 1969 by Prof. Helmut Schaefer, founder of the then department of power economy and power plant engineering. The lecture series was continuously updated in its contents and didactic approach, e.g. by integrating innovative power generation concepts like micro cogeneration plants and fuel cell systems. The focus is on the fundamentals and function of generators, main transformers, auxiliary installations and protective systems in power plant. Apart from the electrotechnical aspects, also aspects of mechanical engineering are gone into. Also discussed are energy conversion concepts fo renewable power generation plants like wind turbines and PV systems. This is the 5th, completely revised edition. It addresses primarily attendants of the lectures but may also serve as a textbook and reference manual for interested experts.

  4. Twelve Scientific Specialists of the Peenemuende Team

    Science.gov (United States)

    2004-01-01

    Twelve scientific specialists of the Peenemuende team at the front of Building 4488, Redstone Arsenal, Huntsville, Alabama. They led the Army's space efforts at ABMA before transfer of the team to National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC). (Left to right) Dr. Ernst Stuhlinger, Director, Research Projects Office; Dr. Helmut Hoelzer, Director, Computation Laboratory: Karl L. Heimburg, Director, Test Laboratory; Dr. Ernst Geissler, Director, Aeroballistics Laboratory; Erich W. Neubert, Director, Systems Analysis Reliability Laboratory; Dr. Walter Haeussermarn, Director, Guidance and Control Laboratory; Dr. Wernher von Braun, Director Development Operations Division; William A. Mrazek, Director, Structures and Mechanics Laboratory; Hans Hueter, Director, System Support Equipment Laboratory;Eberhard Rees, Deputy Director, Development Operations Division; Dr. Kurt Debus, Director Missile Firing Laboratory; Hans H. Maus, Director, Fabrication and Assembly Engineering Laboratory

  5. Review: Susanne Martin (2013. Denken im Widerspruch. Theorie und Praxis nonkonformistischer Intellektueller [Thinking in Contradictions. The Theory and Practice of Nonconformist Intellectuals

    Directory of Open Access Journals (Sweden)

    Georg F. Simet

    2014-05-01

    Full Text Available This publication is the revised version of the author's doctoral thesis. The theory and practice of nonconformist intellectuals is laid out persuasively through focus on three selected intellectuals who played a decisive role in the first three or four decades of the Republic of Germany: Theodor W. ADORNO, Jean AMÉRY, and Günther ANDERS. Their nonconformist approach is then contrasted with the works of Paul F. LAZARSFELD und Helmut SCHELSKY who are introduced as conformists. Although the selected analyses are well chosen, they cannot represent the whole range of nonconformist thinkers. In addition, the comparison made between non-conformism and conformism is too schematic, and the description of and reflection on intellectuals in today's knowledge societies are only partly convincing. Nevertheless, the approach employed here shows some value and should be further developed, applied, and differentiated by analyzing more cases and integrating further contexts. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1402131

  6. Mobility disorders and pain, interrelations that need new research concepts and advanced clinical commitments

    Directory of Open Access Journals (Sweden)

    Sascha Sajer

    2017-12-01

    Full Text Available This Perspective will discuss topics recently suggested by Prof. Helmut Kern, Vienna, Austria, to advance the research activities of his team, that is: Topic A, 10 years post RISE; Topic B, New research for new solutions on old research questions; Topic C, Working groups on nerve regeneration, training-parameters of seniors in different ages, muscle adaptation; and studies of connective tissue and cartilage. This Perspective summarizes some of the basic concepts and of the evidence-based tools for developing further translational research activities. Clinically relevant results will ask for continuous interests of Basic and Applied Myologists and for the support during the next five to ten years of public and private granting agencies. All together, they will end in protocols, devices and multidisciplinary managements for persons suffering with muscle denervation, neuromuscular-related or non-related pain and for the increasing population of old, older and oldest senior citizens in Europe and beyond.

  7. [The development of international pediatric diabetes organizations].

    Science.gov (United States)

    Laron, Zvi

    2010-01-01

    Around 1960, it became clear that, with very few exceptions, the treatment of children with diabetes was not in the hands of paediatricians but in those of adult diabetologists. In 1972, Zvi Laron (Tel Aviv), Henri Lestradet (Paris) and Helmut Loeb (Bruxelles) decided that a separate paediatric association for the care and education of children and adolescents with diabetes was needed. The "International Study Group on Diabetes in Children and Adolescents (ISGD)" was born. In 1993, the name was changed to the "International Society for Pediatric and Adolescent Diabetes (ISPAD)". In 2009, a total of 891 members, from 89 countries, was counted. "Pediatric Diabetes" is the scientific membership journal with an impact factor of 2.424.

  8. Particle accelerator physics

    CERN Document Server

    Wiedemann, Helmut

    2015-01-01

    This book by Helmut Wiedemann is a well-established, classic text, providing an in-depth and comprehensive introduction to the field of high-energy particle acceleration and beam dynamics. The present 4th edition has been significantly revised, updated and expanded. The newly conceived Part I is an elementary introduction to the subject matter for undergraduate students. Part II gathers the basic tools in preparation of a more advanced treatment, summarizing the essentials of electrostatics and electrodynamics as well as of particle dynamics in electromagnetic fields. Part III is an extensive primer in beam dynamics, followed, in Part IV, by an introduction and description of the main beam parameters and including a new chapter on beam emittance and lattice design. Part V is devoted to the treatment of perturbations in beam dynamics. Part VI then discusses the details of charged particle acceleration. Parts VII and VIII introduce the more advanced topics of coupled beam dynamics and describe very intense bea...

  9. Disfunção diafragmática e mortalidade em pacientes portadores de DPOC Diaphragmatic dysfunction and mortality in patients with COPD

    Directory of Open Access Journals (Sweden)

    Wellington Pereira dos Santos Yamaguti

    2009-12-01

    Full Text Available OBJETIVO: Verificar se indivíduos portadores de DPOC com disfunção diafragmática apresentam maior risco de mortalidade quando comparados àqueles sem disfunção diafragmática. MÉTODOS: Foi avaliada a função pulmonar, a mobilidade diafragmática, a qualidade de vida e o índice conhecido como Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE em 42 pacientes portadores de DPOC. Os pacientes foram alocados em dois grupos de acordo com a gravidade do acometimento da mobilidade do diafragma: grupo de baixa mobilidade (BM; mobilidade 34,00 mm. O índice BODE e a qualidade de vida foram quantificados nos dois grupos. Todos os pacientes foram acompanhados prospectivamente por um período de até 48 meses a fim de identificarmos o número de óbitos decorrentes de complicações respiratórias devido a DPOC. RESULTADOS: Dos 42 pacientes avaliados, 20 foram classificados no grupo BM, e 22 foram alocados no grupo AM. Não houve diferenças significativas quanto à faixa etária, hiperinsuflação pulmonar e fatores relacionados à qualidade de vida entre os grupos. Entretanto, o grupo BM apresentou maior pontuação no índice BODE em relação ao grupo AM (p = 0,01. O acompanhamento dos pacientes ao longo de 48 meses permitiu identificar quatro óbitos na população estudada, sendo todos os casos no grupo BM (15,79%; p = 0,02. CONCLUSÕES: Esses resultados sugerem que pacientes portadores de DPOC com disfunção diafragmática, caracterizada por uma baixa mobilidade do diafragma, apresentam maior risco de mortalidade quando comparados àqueles sem disfunção diafragmática.OBJECTIVE: To determine whether COPD patients with diaphragmatic dysfunction present higher risk of mortality than do those without such dysfunction. METHODS: We evaluated pulmonary function, diaphragm mobility and quality of life, as well as determining the Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE index, in 42 COPD

  10. Predicting the Displacement Gain from the Mechanical Quality Factor in Ultrasonic Transducers

    Science.gov (United States)

    DeAngelis, Dominick A.

    The displacement gain is the most important performance parameter for power ultrasonic transducers typically used for welding or cutting: it controls the proportional relationship between the displacement of the tool and the voltage or current input to the transducer, a key process parameter. However, due to the aging effects of the PZT piezoceramics typically used in these transducers, and other variables such as gradual preload loss or tool clamp wear, this displacement gain can drift over time causing a shift in process, and loss of machine-to-machine portability in mass production environments. The "re-calibration" of the displacement gain usually involves a time consuming procedure of standardized controlled tests, and/or measurements using an expensive device such as a laser vibrometer. However, elementary engineering vibrations theory asserts that the displacement gain should be proportional to the static displacement (i.e., 0 Hz or DC) and the mechanical quality factor Qm at resonance, derived from a simple Bode plot, which is already familiar to most transducer designers. This research investigates the methods for obtaining the mechanical quality factor from Bode plots (e.g., constant current or constant voltage sweeps), and ring-down techniques using logarithmic decrement, based on their predictability for determining the displacement gain via the static displacement. The investigation focuses solely on welding transducers for semiconductor wire bonding which employ common hard PZT4 or PZT8 piezoelectric materials. Several other metrics are investigated such as impedance, capacitance and electro-mechanical coupling factor. The experimental and theoretical research methods include Bode plots, equivalent circuits, mechanical analogies and scanning laser vibrometry.

  11. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome.

    Science.gov (United States)

    Fu, Juan-Juan; Gibson, Peter G; Simpson, Jodie L; McDonald, Vanessa M

    2014-01-01

    The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults is not well understood. To examine the prognosis of OADs and to identify potential determinants for longitudinal changes in clinical outcomes. We consecutively recruited 99 older adults (>55 years) with OADs who underwent a multidimensional assessment at baseline and 4 years which involved spirometry, 6-min walk distance (6MWD), assessments of health status (Saint George's Respiratory Questionnaire, SGRQ), comorbidity, and serum and sputum biomarkers. All-cause mortality and respiratory hospitalisation during the follow-up period were recorded. Clinical outcomes were compared between basal and final visits, and changes in clinical outcomes were compared among asthma, COPD and asthma-COPD overlap groups. Associations between clinical parameters, biomarkers and prognosis were examined. After a median follow-up of 4.2 years, outcome data were available for 75 (75.8%) patients. There were 16 (16.2%) deaths. The BODE index predicted all-cause mortality in older people with OADs. While spirometry, 6MWD and SGRQ deteriorated significantly over the 4 years, there was significant heterogeneity in the longitudinal changes in these clinical outcomes. Participants with COPD had a significant decline in FEV1 (p = 0.003), SGRQ (p = 0.030) and 6MWD [decline of 75.5 (93.4) m, p = 0.024]. The change in 6MWD was lower in the asthma-COPD overlap group. Airflow reversibility was associated with a reduced decline in 6MWD. COPD patients had a poor prognosis compared with asthma and asthma-COPD overlap patients. The BODE index is a useful prognostic indicator in older adults with OADs. Both airway disease diagnosis and BODE index warrant specific attention in clinical practice. © 2013 S. Karger AG, Basel.

  12. Browse Author Index

    African Journals Online (AJOL)

    Thampi, C · Thapa, BR · Thatte, MD · Thejaswini, MU · Theodoros, D · Theron, A · Thirsk, I · Thomas-Bode, F · Tiryaki, T · Tiwari, P · Tobih, J E · Todo, S · Tomta, K · Torricelli, M · Touré, B M · Toure, B M · Trifa, M · Tripathy, BB · Trivedi, S · Tsang, T · Tueche, Serge · Tuncel, OK · Turial, S · Turki, AM · Twum, MB · Tzovaras, AA ...

  13. Prospects for spinel-stabilized, high-capacity lithium-ion battery cathodes

    Science.gov (United States)

    Croy, Jason R.; Park, Joong Sun; Shin, Youngho; Yonemoto, Bryan T.; Balasubramanian, Mahalingam; Long, Brandon R.; Ren, Yang; Thackeray, Michael M.

    2016-12-01

    Herein we report early results on efforts to optimize the electrochemical performance of a cathode composed of a lithium- and manganese-rich "layered-layered-spinel" (LLS) material for lithium-ion battery applications. Pre-pilot scale synthesis leads to improved particle properties compared with lab-scale efforts, resulting in high capacities (∼200 mAh g-1) and good energy densities (>700 Wh kgoxide-1) in tests with lithium-ion cells. Subsequent surface modifications give further improvements in rate capabilities and high-voltage stability. These results bode well for advances in the performance of this class of lithium- and manganese-rich cathode materials.

  14. Pavasarnakts : [luuletused] / Andres Ehin ; Andress Ehins, no igaņu valodas atdzejojis Guntars Godiņš

    Index Scriptorium Estoniae

    Ehin, Andres, 1940-2011

    2005-01-01

    Sisu: Pavasarnakts ; Būt suņa dzīvoklim ; "baltajā naktī..." ; Atmiņu bilde ; "ceļas vējsh" ; Sarkankrūtīsha saprāts ; Redzējums ; "dziļi zem zemes dzīvo..." ; Esmu, esmu, esmu... ; Nūdeles un makarona mīlestība ; "aiz vemmorskas bodes..." ; Haiku : [6 haikut] ; Esmu jūsu pazudusī mashīna ; Pakārtais ievārījums : (fragments)

  15. A Delayed Diagnosis: Conflicting Investigation Results Should Be Challenged

    Directory of Open Access Journals (Sweden)

    D. Mital

    2011-01-01

    Full Text Available We present a case where a diagnosis of advanced HIV led to many other diagnoses but more importantly life-threatening multivariant Castleman's disease which is rare and was successfully treated. This case highlights the importance of questioning and challenging investigations when it does not fit with the clinical picture. Multidisciplinary teams are crucial and always seek expert advice if unsure. The much-quoted adage of “many symptoms and signs will fit one diagnosis” also bodes well in this case.

  16. On spatial spillover in feedforward and feedback noise control

    Science.gov (United States)

    Xie, Antai; Bernstein, Dennis

    2017-03-01

    Active feedback noise control for rejecting broadband disturbances must contend with the Bode integral constraint, which implies that suppression over some frequency range gives rise to amplification over another range at the performance microphone. This is called spectral spillover. The present paper deals with spatial spillover, which refers to the amplification of noise at locations where no microphone is located. A spatial spillover function is defined, which is valid for both feedforward and feedback control with scalar and vector control inputs. This function is numerically analyzed and measured experimentally. Obstructions are introduced in the acoustic space to investigate their effect on spatial spillover.

  17. Short- and Long-Term Effects of Concurrent Strength and HIIT Training in Octogenarians with COPD.

    Science.gov (United States)

    Guadalupe-Grau, Amelia; Aznar-Laín, Susana; Mañas, Asier; Castellanos, Juan; Alcázar, Julián; Ara, Ignacio; Mata, Esmeralda; Daimiel, Rosa; García-García, Francisco José

    2017-01-01

    To investigate the short- and long-term effects of concurrent strength and high-intensity interval training (HIIT) on octogenarian COPD patients, nine males (age = 84.2 ± 2.8 years, BMI = 29.3 ± 2.3) with low to severe COPD levels (2.1 ± 1.5 BODE index) underwent a supervised 9-week strength and HIIT exercise program. Training had a significant (p HIIT training increases physical fitness in the oldest-old COPD patients, and has potential long-term benefits.

  18. Design Requirements for High-Efficiency Electronic Ballasts

    Science.gov (United States)

    Takahashi, Yuuji; Shimizu, Keiichi

    The energy loss of an electronic ballast is mainly composed of switch loss and induction loss. The loss decreases when setting the component values so as to reduce the phase angle of the road circuit. However, the lamp current limiting action falls and fails to stably operate the lamp. We have examined the ways to improve the control stability by using the loop transfer function, the bode plot in particular. By designing a control circuit with the experimentally measured loop transfer function and the transfer function of each functional circuit block, the tested lamp was able to operate stably.

  19. Seasonal and diurnal variations in methane and carbon dioxide in the Kathmandu Valley in the foothills of the central Himalayas

    Directory of Open Access Journals (Sweden)

    K. S. Mahata

    2017-10-01

    Full Text Available The SusKat-ABC (Sustainable Atmosphere for the Kathmandu Valley–Atmospheric Brown Clouds international air pollution measurement campaign was carried out from December 2012 to June 2013 in the Kathmandu Valley and surrounding regions in Nepal. The Kathmandu Valley is a bowl-shaped basin with a severe air pollution problem. This paper reports measurements of two major greenhouse gases (GHGs, methane (CH4 and carbon dioxide (CO2, along with the pollutant CO, that began during the campaign and were extended for 1 year at the SusKat-ABC supersite in Bode, a semi-urban location in the Kathmandu Valley. Simultaneous measurements were also made during 2015 in Bode and a nearby rural site (Chanban  ∼  25 km (aerial distance to the southwest of Bode on the other side of a tall ridge. The ambient mixing ratios of methane (CH4, carbon dioxide (CO2, water vapor, and carbon monoxide (CO were measured with a cavity ring-down spectrometer (G2401; Picarro, USA along with meteorological parameters for 1 year (March 2013–March 2014. These measurements are the first of their kind in the central Himalayan foothills. At Bode, the annual average mixing ratios of CO2 and CH4 were 419.3 (±6.0 ppm and 2.192 (±0.066 ppm, respectively. These values are higher than the levels observed at background sites such as Mauna Loa, USA (CO2: 396.8 ± 2.0 ppm, CH4: 1.831 ± 0.110 ppm and Waliguan, China (CO2: 397.7 ± 3.6 ppm, CH4: 1.879 ± 0.009 ppm during the same period and at other urban and semi-urban sites in the region, such as Ahmedabad and Shadnagar (India. They varied slightly across the seasons at Bode, with seasonal average CH4 mixing ratios of 2.157 (±0.230 ppm in the pre-monsoon season, 2.199 (±0.241 ppm in the monsoon, 2.210 (±0.200 ppm in the post-monsoon, and 2.214 (±0.209 ppm in the winter season. The average CO2 mixing ratios were 426.2 (±25.5 ppm in the pre-monsoon, 413.5 (±24.2 ppm in the monsoon

  20. Separation of human milk oligosaccharides using high-performance anion-exchange chromatography with pulsed amperometric detection

    DEFF Research Database (Denmark)

    Lie, Aleksander; Pedersen, Lars Haastrup

    -N-neotetraose, among others. As the basis for HPAE elution methods, the retention times and separation of various mono- and oligosaccharides were investigated as depending on eluent concentrations of NaOH and NaOAc, using a CarboPac PA1 column. The studied monosaccharides and several of the oligosaccharides exhibited...... maximum retention at distinct concentrations of NaOH. In addition, the different species showed varying relations between eluent composition and retention time, resulting in varying separation and even changes in elution order with different elution conditions. References: Bode L, Jantscher-Krenn E. (2012...

  1. Analysis of human milk oligosaccharides using high-performance anion-exchange chromatography with pulsed amperometric detection

    DEFF Research Database (Denmark)

    Lie, Aleksander; Pedersen, Lars Haastrup

    and temperature, using a CarboPac PA1 column. Specifically, the retention times and separations of various mono- and oligosaccharides, as depending on the eluent concentrations of NaOH and NaOAc, was studied. The investigated monosaccharides and several of the disaccharides exhibited maximum retention at distinct...... concentrations of NaOH. In addition, the different species showed varying relations between eluent composition and retention time, resulting in varying separation and even changes in elution order with different elution conditions. References: Bode L, Jantscher-Krenn E. (2012) Adv. Nutr. 3: 383S Lee YC. (1990...

  2. Produção em vaso e pós-colheita de hastes de pimentas ornamentais (Capsicum spp)

    OpenAIRE

    França, Christiane de Fátima Martins

    2015-01-01

    O cultivo de pimenteiras como planta ornamental de vaso e corte tem se expandido consideravelmente no Brasil e no mundo. Foi realizado um experimento durante a produção de pimentas ornamentais envasadas com o objetivo de avaliar o efeito do paclobutrazol no crescimento e qualidade ornamental de duas variedades comerciais de pimentas (Iracema Biquinho Vermelha e Bode Amarela), e em dois acessos do banco de germoplasma da Universidade Federal da Paraíba (2334PB e 2345PB). Outros cinco experimen...

  3. The Application of Parameter Space Design Method for Generator Excitation Control

    Science.gov (United States)

    Iki, Hiroyuki; Yoshimura, Shyuta; Uriu, Yosihisa

    Recently, control engineering changes from classical control theory to modern control theory, and analogue to digital. However, as a matter of fact, the sensitivity adjustment of the parameters using Bode diagram require many time and works. In this paper, the tool of Matlab/Simulink that adjusted the AVR control parameter of the PI control type brushless and Thyristor excitation method by using the technique for based on the parameter space planning method by QE was made. Moreover, the adjustment of the sensitivity parameter of the excitation control method intended for the dynamic stability level area in Single Machine Infinite Bus is examined with the tool.

  4. The Respiratory Impedance in an Asymmetric Model of the Lung Structure

    Directory of Open Access Journals (Sweden)

    Robin De Keyser

    2011-01-01

    Full Text Available This paper presents a model of the respiratory tree as a recurrent, but asymmetric, structure. The intrinsic properties posed by such a system lead to a multi-fractal structure, i.e. a non-integer order model of the total impedance. The fractional order behavior of the asymmetric tree simulated as a dynamic system is assessed by means of Bode plots, on a wide range of frequencies. The results indicate than in a specific frequency range, both the symmetric
    and asymmetric representation of the respiratory tree lead to similar values in the impedance.

  5. Hall v. Florida: defining intellectual disability in the shadow of the death penalty.

    Science.gov (United States)

    Appelbaum, Paul S

    2014-10-01

    When the U.S. Supreme Court held that persons with mental retardation (now called intellectual disability) could not be sentenced to death, it left the question of how to define the condition to the states. That issue was raised in Hall v. Florida, which challenged one state's "bright-line rule" barring consideration of defendants with IQs over 70. In an endorsement of the professional consensus, the justices ruled that a more flexible approach that takes into account both intellectual and adaptive functioning is required. The Court's posture may bode well for its acceptance of mental health expertise in future cases.

  6. Prognostic Value of C-Reactive Protein, Leukocytes, and Vitamin D in Severe Chronic Obstructive Pulmonary Disease

    DEFF Research Database (Denmark)

    Moberg, Mia; Vestbo, Jørgen; Martinez, Gerd

    2014-01-01

    Inflammatory biomarkers predict mortality and hospitalisation in chronic obstructive pulmonary disease (COPD). Yet, it remains uncertain if biomarkers in addition to reflecting disease severity add new prognostic information on severe COPD. We investigated if leukocytes, C-reactive protein (CRP......), and vitamin D were independent predictors of mortality and hospitalisation after adjusting for disease severity with an integrative index, the i-BODE index. In total, 423 patients participating in a pulmonary rehabilitation programme, with a mean value of FEV1 of 38% of predicted, were included. Mean followup...

  7. Liposomes as Safe Carriers of Drugs and Vaccines,

    Science.gov (United States)

    1992-01-01

    eotmpomftion. Fi U 1 Cancer 16: 1529)-153s 24. Leon A, llensegnu 1). Toffano G. Orlando P. Massari P I l-4X Eftcct of brain contes phospholipids on adenylate...Juliano RL. Bodes (f’I (19~85 I Liposomal am photeriein B for the treatment ol ytei fungcal inrfections in patients with cancer . A preliminarl, %tud%. J1...Transplantation 40: 96-") 31. Ntivamoto K. Schultz F. Heath T. Mitchell MD). Albertinc KII. StU~b NC II 08) Pulmon irs tntra)sascular macrophagces and

  8. 500 million people with no access to power - How India can tackle its severe power shortage during the next decades?

    Energy Technology Data Exchange (ETDEWEB)

    Kiss, Peter; Sagodi, Attila

    2010-09-15

    India's population, now around 1.1 billion (out of which 500 million are not yet connected to the grid), is growing fast, and is expected to surpass that of China soon after 2020. Its economy is also expanding and is expected to be over 9 percent for most of the next decade. All of this bodes well for the electricity sector; consumption, currently at 600TWh annually, is set to double by 2020. To meet this demand, total generating capacity should jump by 90 GW, to 241GW, with an increased emphasis on nuclear, clean coal and renewables, including solar and small-hydro.

  9. Eficacia de la Fisioterapia respiratoria estandarizada en Atención Primaria en los pacientes con EPOC moderada y su evaluación económica

    OpenAIRE

    Inglés Novell, Mª Montserrat

    2010-01-01

    OBJETIVOSEvaluar la eficacia sobre la calidad de vida y diversos factores predictores de la mortalidad (índice BODE, distancia caminada en 6 minutos, FEV1, disnea e índice de masa corporal) y el impacto económico de un programa de Fisioterapia Respiratoria Estandarizado realizado en Atención Primaria (FREAP) en enfermos con EPOC moderada a los 6 meses de su implementación.MÉTODODiseño: Ensayo clínico controlado aleatorizado. Emplazamiento: 14 equipos de atención primaria y 8 unidades de fisi...

  10. John Norris, Collision Course: NATO, Russian and Kosovo (foreword by Strobe Talbott. Westport: Praeger Publishers, 2005. 333 pages.

    Directory of Open Access Journals (Sweden)

    Guillaume Colin

    2006-11-01

    Full Text Available Recension requires thoroughness in reading and examining a book, including its cover. In this connection, the cover of John Norris' book bodes ill for its content. A physical map with mountains, waterways, a few localities - most of which are half hidden by the title. However, enough of them can be made out (Argun, Aksay, Khasavyurt, Gudermes... to understand that this is no map of Kosovo but that of Chechnya! Could anyone fail to suspect an unfortunate mistake, a slip of the pen confirming ...

  11. Hydrogel Biomaterials: A Smart Future?

    Science.gov (United States)

    Kopeček, Jindřich

    2007-01-01

    Hydrogels were the first biomaterials developed for human use. The state-of-the-art and potential for the future are discussed. Recently, new designs have produced mechanically strong synthetic hydrogels. Protein based hydrogels and hybrid hydrogels containing protein domains present a novel advance; such biomaterials may self-assemble from block or graft copolymers containing biorecognition domains. One of the domains, the coiled-coil, ubiquitously found in nature, has been used as an example to demonstrate the developments in the design of smart hydrogels. The application potential of synthetic, protein-based, DNA-based, and hybrid hydrogels bodes well for the future of this class of biomaterials. PMID:17697712

  12. Seasonal and diurnal variations in methane and carbon dioxide in the Kathmandu Valley in the foothills of the central Himalayas

    Science.gov (United States)

    Singh Mahata, Khadak; Panday, Arnico Kumar; Rupakheti, Maheswar; Singh, Ashish; Naja, Manish; Lawrence, Mark G.

    2017-10-01

    The SusKat-ABC (Sustainable Atmosphere for the Kathmandu Valley-Atmospheric Brown Clouds) international air pollution measurement campaign was carried out from December 2012 to June 2013 in the Kathmandu Valley and surrounding regions in Nepal. The Kathmandu Valley is a bowl-shaped basin with a severe air pollution problem. This paper reports measurements of two major greenhouse gases (GHGs), methane (CH4) and carbon dioxide (CO2), along with the pollutant CO, that began during the campaign and were extended for 1 year at the SusKat-ABC supersite in Bode, a semi-urban location in the Kathmandu Valley. Simultaneous measurements were also made during 2015 in Bode and a nearby rural site (Chanban) ˜ 25 km (aerial distance) to the southwest of Bode on the other side of a tall ridge. The ambient mixing ratios of methane (CH4), carbon dioxide (CO2), water vapor, and carbon monoxide (CO) were measured with a cavity ring-down spectrometer (G2401; Picarro, USA) along with meteorological parameters for 1 year (March 2013-March 2014). These measurements are the first of their kind in the central Himalayan foothills. At Bode, the annual average mixing ratios of CO2 and CH4 were 419.3 (±6.0) ppm and 2.192 (±0.066) ppm, respectively. These values are higher than the levels observed at background sites such as Mauna Loa, USA (CO2: 396.8 ± 2.0 ppm, CH4: 1.831 ± 0.110 ppm) and Waliguan, China (CO2: 397.7 ± 3.6 ppm, CH4: 1.879 ± 0.009 ppm) during the same period and at other urban and semi-urban sites in the region, such as Ahmedabad and Shadnagar (India). They varied slightly across the seasons at Bode, with seasonal average CH4 mixing ratios of 2.157 (±0.230) ppm in the pre-monsoon season, 2.199 (±0.241) ppm in the monsoon, 2.210 (±0.200) ppm in the post-monsoon, and 2.214 (±0.209) ppm in the winter season. The average CO2 mixing ratios were 426.2 (±25.5) ppm in the pre-monsoon, 413.5 (±24.2) ppm in the monsoon, 417.3 (±23.1) ppm in the post-monsoon, and 421.9 (±20

  13. COMET: a multicomponent home-based disease-management programmeversusroutine care in severe COPD.

    Science.gov (United States)

    Kessler, Romain; Casan-Clara, Pere; Koehler, Dieter; Tognella, Silvia; Viejo, Jose Luis; Dal Negro, Roberto W; Díaz-Lobato, Salvador; Reissig, Karina; Rodríguez González-Moro, José Miguel; Devouassoux, Gilles; Chavaillon, Jean-Michel; Botrus, Pierre; Arnal, Jean-Michel; Ancochea, Julio; Bergeron-Lafaurie, Anne; De Abajo, Carlos; Randerath, Winfried J; Bastian, Andreas; Cornelissen, Christian G; Nilius, Georg; Texereau, Joëlle B; Bourbeau, Jean

    2018-01-01

    The COPD Patient Management European Trial (COMET) investigated the efficacy and safety of a home-based COPD disease management intervention for severe COPD patients.The study was an international open-design clinical trial in COPD patients (forced expiratory volume in 1 s management intervention or to the usual management practices at the study centre. The disease management intervention included a self-management programme, home telemonitoring, care coordination and medical management. The primary end-point was the number of unplanned all-cause hospitalisation days in the intention-to-treat (ITT) population. Secondary end-points included acute care hospitalisation days, BODE (body mass index, airflow obstruction, dyspnoea and exercise) index and exacerbations. Safety end-points included adverse events and deaths.For the 157 (disease management) and 162 (usual management) patients eligible for ITT analyses, all-cause hospitalisation days per year (mean±sd) were 17.4±35.4 and 22.6±41.8, respectively (mean difference -5.3, 95% CI -13.7 to -3.1; p=0.16). The disease management group had fewer per-protocol acute care hospitalisation days per year (p=0.047), a lower BODE index (p=0.01) and a lower mortality rate (1.9% versus 14.2%; pmanagement intervention did not significantly reduce unplanned all-cause hospitalisation days, but reduced acute care hospitalisation days and mortality in severe COPD patients. Copyright ©ERS 2018.

  14. Study of metal corrosion using ac impedance techniques in the STS launch environment

    Science.gov (United States)

    Calle, Luz M.

    1989-01-01

    AC impedance measurements were performed to investigate the corrosion resistance of 19 alloys under conditions similar to the STS launch environment. The alloys were: Zirconium 702, Hastelloy C-22, Inconel 625, Hastelloy C-276, Hastelloy C-4, Inconel 600, 7Mo + N, Ferralium 255, Inco Alloy G-3, 20Cb-3, SS 904L, Inconel 825, SS 304LN, SS 316L, SS 317L, ES 2205, SS 304L, Hastelloy B-2, and Monel 400. AC impedance data were gathered for each alloy after one hour immersion time in each of the following three electrolyte solutions: 3.55 percent NaCl, 3.55 percent NaCl-0.1N HCl, and 3.55 percent NaCl-1.0N HCl. The data were analyzed qualitatively using the Nyquist plot and quantitatively using the Bode plot. Polarization resistance, Rp, values were obtained using the Bode plot. Zirconium 702 was the most corrosion resistant alloy in the three electrolytes. The ordering of the other alloys according the their resistance to corrosion varied as the concentration of hydrochloric acid in the electrolyte increased. The corrosion resistance of Zirconium 702 and Ferralium 255 increased as the concentration of hydrochloric acid in the electrolyte increased. The corrosion resistance of the other 17 alloys decreased as the concentration of the hyrdochloric acid in the electrolyte increased.

  15. Discovery of the first asteroid, Ceres historical studies in asteroid research

    CERN Document Server

    Cunningham, Clifford

    2016-01-01

    Based on extensive primary sources, many never previously translated into English, this is the definitive account of the origins of Ceres as it went from being classified as a new planet to reclassification as the first of a previously unknown group of celestial objects. Cunningham opens this critical moment of astronomical discovery to full modern analysis for the first time. This book includes all the voluminous correspondence, translated into English, between the astronomers of Europe about the startling discovery of Ceres by Piazzi in 1801. It covers the period up to March 1802, at which time Pallas was discovered. Also included are Piazzi's two monographs about Ceres, and the sections of two books dealing with Ceres, one by Johann Bode, the other by Johann Schroeter. The origin of the word 'asteroid' is explained, along with several chapters on the antecedents of the story going back to ancient Greek times. The formulation of Bode's Law is given, as are the details on the efforts of Baron von Zach to org...

  16. Veterans with chronic obstructive pulmonary disease achieve clinically relevant improvements in respiratory health after pulmonary rehabilitation.

    Science.gov (United States)

    Major, Stephen; Moreno, Marcella; Shelton, John; Panos, Ralph J

    2014-01-01

    To measure respiratory health and respiratory-related (RR) health care utilization in veterans with chronic obstructive pulmonary disease referred to pulmonary rehabilitation (PR) at the Cincinnati Veterans Administration (VA) Medical Center. We reviewed the records of 430 patients referred for PR from 2008 to 2010: 78 met inclusion criteria and completed PR (PR group); 92 qualified for PR but declined participation (referral group). All PR participants completed the St. George's Respiratory Questionnaire (SGRQ), BODE index, 6-minute walk test (6MWT), UCSD Shortness of Breath Questionnaire (UCSDSOBQ), Pulmonary Disease Knowledge Test, and self-reported use of short-acting bronchodilators before and after PR. All VA health care encounters during the 12 months before and after PR (PR group) or referral (referral group) were reviewed. Respiratory health improved after PR: SGRQ (60.6 ± 15.1, 51.1 ± 16.7), BODE (4.65 ± 1.93, 3.41 ± 1.84), 6MWT (497 ± 367 m, 572 ± 397 m), UCSDSOBQ (68.3 ± 21.1, 61.0 ± 20.9), Pulmonary Disease Knowledge Test (75.9 ± 12.4%, 85.9 ± 11.1%), short-acting bronchodilator (22.5 ± 25.3, 12.8 ± 15.6 inhalations per week) (before, after PR; P rehabilitation improves respiratory health in veterans with chronic obstructive pulmonary disease and decreases RR health care utilization.

  17. Effects of two Chinese herbal formulae for the treatment of moderate to severe stable chronic obstructive pulmonary disease: a multicenter, double-blind, randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Genfa Wang

    Full Text Available The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD.A multicenter, double-blind, double-dummy, and randomized controlled trial (RCT was conducted. All groups were treated with additional conventional medicines. There were a 6-month treatment and a 12-month follow-up for 5 times. Primary outcomes included lung function test, exacerbation frequency, score of SGRQ. Second outcomes consisted of 6MWD, BODE index, psychological field score, inflammatory factors and cortisol.A total of 331 patients were randomly divided into two active treatment groups (Bushen Yiqi (BY granule group, n = 109; Bushen Fangchuan (BF tablet group, n = 109 and a placebo group (n = 113. Finally 262 patients completed the study. BY granule & BF tablet increased the values of VC, FEV1 (% and FEV1/FVC (%, compared with placebo. BY granule improved PEF. Both treatments reduced acute exacerbation frequency (P = 0.067, BODE index and psychological field score, while improved 6MWD. In terms of descent rang of SGRQ score, both treatments increased (P = 0.01. Both treatments decreased inflammatory cytokines, such as IL-8, and IL-17(P = 0.0219. BY granule obviously descended IL-17(P0.05 among three groups.BY granule and BF tablet were positively effective for the treatment of COPD, and the former performed better in general.Chinese Clinical Trial Register center ChiCTR-TRC-09000530.

  18. Evaluation of paclobutrazol application method on quality characteristics of ornamental pepper

    Directory of Open Access Journals (Sweden)

    Christiane de Fátima Martins França

    2017-10-01

    Full Text Available The effects of three paclobutrazol (PBZ application methods on ornamental characteristics of two pepper cultivars (‘Biquinho Vermelha’ and ‘Bode Amarela’ were evaluated. Plant growth regulator at 10 μM PBZ was added at transplanting by drenching 250 mL PBZ solution on the pot substrate, foliar spray of 10 mL PBZ solution or by submerging seedlings root + substrate for 10 seconds in the PBZ solution. Control plants were treated with tap water applied directly on the substrate. Plant height, canopy compactness, fruits and leaves number, and leaf chlorophyll content were evaluated when 50% of the plants had approximately 30% of mature fruits (commercial maturity. PBZ applied by drenching influenced positively the ornamental characteristics of ‘Bode Amarela’. Otherwise, the best PBZ application method for ‘Biquinho Vermelha’ was not established. The results suggest that search for suitable PBZ application method that no affects the pepper ornamental characteristics must be done specifically for each pepper cultivar.

  19. The association of metabolic syndrome with adipose tissue hormones and insulin resistance in patients with COPD without co-morbidities.

    Science.gov (United States)

    Minas, Markos; Kostikas, Konstantinos; Papaioannou, Andriana I; Mystridou, Parthena; Karetsi, Eleni; Georgoulias, Panagiotis; Liakos, Nikolaos; Pournaras, Spyros; Gourgoulianis, Konstantinos I

    2011-12-01

    Chronic obstructive pulmonary disease (COPD) and metabolic syndrome represent common causes of morbidity and mortality in ageing populations. The effect of the co-existence of COPD and metabolic syndrome on adipose tissue hormones and insulin resistance as well as the differences between COPD patients with and without metabolic syndrome have not been adequately studied. The prevalence of metabolic syndrome, based on Adult Treatment Panel III (ATP III) criteria, was evaluated in 114 male patients with COPD without significant co-morbidities. Pulmonary functions tests (PFTs), arterial blood gases, quality of life and BODE index were assessed. Blood samples were obtained for the assessment of adipose tissue hormones and insulin resistance. The overall prevalence of metabolic syndrome was 21%, being more prevalent in earlier stages of COPD. Patients with COPD and metabolic syndrome were younger with higher body-mass index (BMI), had better pulmonary function, less static hyperinflation and air-trapping, better diffusing capacity for carbon monoxide and BODE index. These patients had higher levels of leptin, lower levels of adiponectin and increased insulin resistance, as expressed by HOMA index, compared with patients without metabolic syndrome. Metabolic syndrome was more prevalent in younger patients with less severe COPD. These patients may constitute a specific COPD phenotype with greater leptin to adiponectin imbalance and insulin resistance, despite smaller impairment in PFTs. The prognosis and differences of these patients compared with other COPD phenotypes needs to be determined in prospective studies.

  20. Relay feedback tuning of robust PID controllers with iso-damping property.

    Science.gov (United States)

    Chen, YangQuan; Moore, Kevin L

    2005-02-01

    A new tuning method for proportional-integral-derivative (PID) controller design is proposed for a class of unknown, stable, and minimum phase plants. We are able to design a PID controller to ensure that the phase Bode plot is flat, i.e., the phase derivative w.r.t. the frequency is zero, at a given frequency called the "tangent frequency" so that the closed-loop system is robust to gain variations and the step responses exhibit an iso-damping property. At the "tangent frequency," the Nyquist curve tangentially touches the sensitivity circle. Several relay feedback tests are used to identify the plant gain and phase at the tangent frequency in an iterative way. The identified plant gain and phase at the desired tangent frequency are used to estimate the derivatives of amplitude and phase of the plant with respect to frequency at the same frequency point by Bode's integral relationship. Then, these derivatives are used to design a PID controller for slope adjustment of the Nyquist plot to achieve the robustness of the system to gain variations. No plant model is assumed during the PID controller design. Only several relay tests are needed. Simulation examples illustrate the effectiveness and the simplicity of the proposed method for robust PID controller design with an iso-damping property.

  1. The Schäfertal-Catchment - An intensive research site within the TERENO Harz/Central German Lowland Observatory

    Science.gov (United States)

    Wollschläger, U.; Baeßler, C.; de Rooij, G. H.; Dietrich, P.; Fleckenstein, J. H.; Frenzel, M.; Klotz, S.; Lausch, A.; Martini, E.; Musolff, A.; Oswald, S.; Pause, M.; Reinstorf, F.; Rode, M.; Samaniego-Eguiguren, L.; Vogel, H.-J.; Werban, U.; Zacharias, S.

    2012-04-01

    The Bode river catchment in the TERENO Harz/Central German Lowland Observatory is the central study area for water-related research at the Helmholtz Centre for Environmental Research - UFZ. As integral part of the TERENO observation network of the Helmholtz Association, an integrated monitoring and research concept joining hydrological, atmospheric, biodiversity-related, and soil physical research is currently being implemented. The observation concept has been designed following a nested catchment monitoring approach comprising highly instrumented, intensive research sites as smallest units. We present an overview of the Schäfertal-Catchment, one of the intensive research sites within the Bode Hydrological Observatory. The central research goal is the long-term investigation of the catchment water budget and the feedbacks with climatic, pedological, geological, and ecological drivers. In this context three main research packages have been defined: (i) monitoring and modelling of water fluxes from the point to the catchment scale, (ii) soil-landscape-modelling, and (iii) investigation of biodiversity and ecosystem functioning. Within the Schäfertal several technologies for soil hydrological monitoring are combined in order to observe meso-scale vadose zone hydrological processes. In this presentation, the general research concept as well as conceptual approaches for the different specific research hypotheses are described. First results of ongoing monitoring activities are presented and discussed.

  2. Impact of the German Harz Mountain Weichselian ice-shield and valley glacier development onto Palaeolithic and megafauna disappearances

    Science.gov (United States)

    Diedrich, C.

    2013-12-01

    Three Pleistocene stages are recorded by 3D Google-Earth geomorphology, cave sediments, river terraces, megafauna, archaeological sites of the Harz Mountain Range and its forelands of northern Germany (central Europe, peak 1141 a.s.l.). Late Pleistocene glaciation stages are modeled preliminary in valley elevations between 407 and 760 a.s.l., starting all southeast below the Brocken Ice Field (above 750 a.s.l.). The 14-11 km long Oder and Bode Valley glaciers left typical moraines, kames, or dead ice depressions, such as fluvial cave relic sediments. The Bode River glacier passed during the LGM the Rübeland Caves, where it deposited reworked kames/lateral moraines in the Baumann's Cave, which floods mixed a Neanderthal camp, leopard lair and cave bear den area. 60 km downstream, fluvial to aeolian deposits were trapped in the gypsum karst doline Westeregeln (Neanderthal camp/hyena den). Late Aurignacians replaced in the region Neanderthals, but a gap of Late Palaeolithic (Gravettian-Magdalenian - 26,000-16,000 BP) settlement, and latest starting speleothem genesis (around 24,260 ± 568 BP) correlate to the LGM, when an "arctic reindeer fauna" with alpine elements (ibex, chamois) accumulated in bone assemblages of a wolverine, polar fox, mustelid, such as European eagle owl dens, which allow landscape reconstructions.

  3. Predictive Model for Anxiety and Depression in Spanish Patients with Stable Chronic Obstructive Pulmonary Disease.

    Science.gov (United States)

    González-Gutiérrez, María Victoria; Guerrero Velázquez, José; Morales García, Concepción; Casas Maldonado, Francisco; Gómez Jiménez, Francisco Javier; González Vargas, Francisco

    2016-03-01

    The association between chronic obstructive pulmonary disease (COPD) and anxiety and depression is not yet completely characterized, and differences between countries may exist. We used a predictive model to assess this association in a Spanish population. Prospective transversal descriptive study of 204 patients with stable COPD. Concomitant anxiety or depression were diagnosed by psychiatric assessment, using the diagnostic criteria of the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10). Sociodemographic, clinical and lung function parameters were analyzed. In total, 36% of stable COPD patients had psychiatric comorbidities, but 76% were unaware of their diagnosis. Nineteen percent had a pure anxiety disorder, 9.8% had isolated depression, and 7.3% had a mixed anxiety-depression disorder. Predictive variables in the multivariate analysis were younger age, higher educational level, lack of home support, higher BODE index, and greater number of exacerbations. The ROC curve of the model had an AUC of 0.765 (P<0.001). In COPD, concomitant psychiatric disorders are significantly associated with sociodemographic factors. Anxiety disorders are more common than depression. Patients with more severe COPD, according to BODE, younger patients and those with a higher educational level have a greater risk of being diagnosed with anxiety or depression in a structured psychiatric interview. In our population, most patients with psychiatric comorbidities remain unidentified. Copyright © 2015 SEPAR. Published by Elsevier Espana. All rights reserved.

  4. Caracterización eléctrica de tejido sanguíneo mediante función de transferencia Caracterización eléctrica de tejido sanguíneo mediante función de transferencia

    Directory of Open Access Journals (Sweden)

    Pascual Palomares Anda

    2012-02-01

    Full Text Available This paper presents an analysis and modeling of electrical impedance spectra applied to the study of experimental data of blood tissue and its main components: red cells, white and plasma. Using the electrical circuit theory yields the transfer functions and the graphic representation of Bode and Nyquist. You can see in this work the experimental technique’s potential to differentiate cellular components of blood tissue, and the usefulness of developing accurate models for analysis. En este trabajo se presenta un análisis y modelado de espectros de impedancia eléctrica aplicados al estudio de datos experimentales de tejido sanguíneo y sus principales componentes: glóbulos rojos, blancos y plasma. Usando la teoría de circuitos eléctricos se obtienen las funciones de transferencia y la representación gráfica de Bode y Nyquist. Se puede ver en este trabajo el potencial de la técnica experimental para diferenciar los elementos que forman al tejido sanguíneo, así como la utilidad de desarrollar modelos precisos para su análisis.

  5. Quantitative computed tomography measurements to evaluate airway disease in chronic obstructive pulmonary disease: Relationship to physiological measurements, clinical index and visual assessment of airway disease

    Energy Technology Data Exchange (ETDEWEB)

    Nambu, Atsushi, E-mail: nambu-a@gray.plala.or.jp [Department of Radiology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 (United States); Zach, Jordan, E-mail: ZachJ@NJHealth.org [Department of Radiology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 (United States); Schroeder, Joyce, E-mail: Joyce.schroeder@stanfordalumni.org [Department of Radiology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 (United States); Jin, Gongyoung, E-mail: gyjin@chonbuk.ac.kr [Department of Radiology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 (United States); Kim, Song Soo, E-mail: haneul88@hanmail.net [Department of Radiology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 (United States); Kim, Yu-IL, E-mail: kyionly@chonnam.ac.kr [Department of Medicine, National Jewish Health, Denver, CO (United States); Schnell, Christina, E-mail: SchnellC@NJHealth.org [Department of Medicine, National Jewish Health, Denver, CO (United States); Bowler, Russell, E-mail: BowlerR@NJHealth.org [Division of Pulmonary Medicine, Department of Medicine, National Jewish Health (United States); Lynch, David A., E-mail: LynchD@NJHealth.org [Department of Radiology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 (United States)

    2016-11-15

    Purpose: To correlate currently available quantitative CT measurements for airway disease with physiological indices and the body-mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index in patients with chronic obstructive pulmonary disease (COPD). Materials and methods: This study was approved by our institutional review board (IRB number 2778). Written informed consent was obtained from all subjects. The subjects included 188 current and former cigarette smokers from the COPDGene cohort who underwent inspiratory and expiratory CT and also had physiological measurements for the evaluation of airflow limitation, including FEF25-75%, airway resistance (Raw), and specific airway conductance (sGaw). The BODE index was used as the index of clinical symptoms. Quantitative CT measures included % low attenuation areas [% voxels ≤ 950 Hounsfield unit (HU) on inspiratory CT, %LAA{sub −950ins}], percent gas trapping (% voxels ≤ −856 HU on expiratory CT, %LAA {sub −856exp}), relative inspiratory to expiratory volume change of voxels with attenuation values from −856 to −950 HU [Relative Volume Change (RVC){sub −856} {sub to} {sub −950}], expiratory to inspiratory ratio of mean lung density (E/I-ratio {sub MLD}), Pi10, and airway wall thickness (WT), luminal diameter (LD) and airway wall area percent (WA%) in the segmental, subsegmental and subsubsegmental bronchi on inspiratory CT. Correlation coefficients were calculated between the QCT measurements and physiological measurements in all subjects and in the subjects with mild emphysema (%LAA{sub −950ins} <10%). Univariate and multiple variable analysis for the BODE index were also performed. Adjustments were made for age, gender, smoking pack years, FEF25-75%, Raw, and sGaw. Results: Quantitative CT measurements had significant correlations with physiological indices. Among them, E/I-ratio {sub MLD} had the strongest correlations with FEF25-75% (r = −0.648, <0.001) and sGaw (r = −0

  6. Biogas in the agriculture. State of the art. Proceedings; Biogas in der Landwirtschaft. Stand und Perspektiven. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Within the meeting of the Association for Technology and Structures in Agriculture (Darmstadt, Federal Republic of Germany) and the Agency for Renewable Resources (Guelzow, Federal Republic of Germany) between 15th and 16th September, 2009, in Weimar the following lectures were held: (1) Results of the actual biogas measurement II (Peter Weiland); (2) Agitators in biogas plants - Technology with central significance (Kay Rostalski); (3) How much energy is needed by a biogas fermenter? (Ludwig Heinloth); (4) The fermentation concept of Rueckert NatUrgas GmbH (Claus Rueckert, Dominique Pfeufer); (5) Experiences from the construction for the practice of the company MT-Energie GmbH (Bodo Drescher); (6) Fermenter/technology concept of Schmack Biogas AG (Thomas Moeeslinger); (7) Transport of biomass - How much does the logistics of Guelle and Co. cost? (Thore Toews); (8) Which factors determine the efficiency of biogas plants? (Gerd Reinhold); (9) Microbial diversity in biogas reactors in the fermentation of renewable raw materials (Michael Klocke et al.); (10) What do additives and ingredients contribute to the optimisation of the production of biogas? (Udo Hoelker); (11) Process optimisation - An interaction between technology and microbiology (Andreas Gronauer et al.); (12) Emissions at the production of biogas - an analysis if the environmental relevance (Joachim Clemens et al.); (13) Support systems for energy plants - Consequences to soil and environment (Matthias Willms et al.); (14) How ecological is biogas? (Sven Gaertner); (15) Biogas plant - Analysis of construction and operation from licensing view (Hans-Walter Schneichel); (16) Biogas plants - Analysis of construction and operation from contractual legal view (Florian Valentin); (17) Biogasplants - Analysis of construction and operation from remuneration legal view (Helmut Loibl); (18) Process and costs of treatment of residues of fermentation (Sebastian Wulf, Helmut Doehler); (19) How do residues of

  7. The escaping "pneuma" - gas of ancient earthquake concepts in relation to animal, atmospheric and thermal precursors

    Science.gov (United States)

    Helmut, Tributsch

    2013-04-01

    The escaping "pneuma" - gas of ancient earthquake concepts in relation to animal, atmospheric and thermal precursors Helmut Tributsch Present affiliation: Carinthian University for Applied Sciences, Bio-mimetics program, Europastrasse 4, 9524 Villach, Austria, helmut.tributsch@alice.it Retired from: Free University Berlin, Institute for physical and theoretical chemistry, Takustr. 3, 14195 Berlin, Germany. For two thousand years ancient European and medieval (including islamic) natural philosophers have considered a dry, warm gas, the "pneuma" ( breath, exhalation), escaping from the earth, as precursor and trigger of earthquakes. Also in China an escaping gas or breath (the qi) was considered the cause of earthquake, first in a document from 780 BC. We know today that escaping gas is not causing earthquakes. But it may be that natural phenomena that supported such a pneuma-concept have again and again been observed. The unpolluted environment and the largely absence of distracting artificial stimuli may have allowed the recognition of distinct earthquake precursors, such as described by ancient observers: (1) the sun becomes veiled and has a dim appearance, turns reddish or dark (2) a narrow long stretched cloud becomes visible, like a line drawn by a ruler, (3) earthquakes preceded by a thin streak of cloud stretching over a wide space. (4) earthquakes in the morning sometimes preceded by a still and a strong frost, (5) a surf - line of the air sea is forming (near the horizon). The described phenomena may be interpreted as a kind of smog forming above the ground prior to an earthquake, a smog exhaled from the ground, which is triggering water condensation, releasing latent heat, changing visibility, temperature, heat conduction and radiation properties. This could perfectly match the phenomenon, which is at the origin of satellite monitored temperature anomalies preceding earthquakes. Based on a few examples it will be shown that the time window of temperature

  8. Symposium energy plants 2007; Symposium Energiepflanzen 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    the agricultural engineering industry (Horst Weigelt); (u) Development, testing and demonstration of new logistic concepts for biofuels (Stefan Vodegel); (v) Evaluation of biogas substrates by means of NIRS (Helmut Messner); (w) Data collection energy plants (Helmut Doehler).

  9. History of anesthesia in Germany.

    Science.gov (United States)

    Wawersik, J

    1991-01-01

    The first ether anesthetic was administered in Germany by J.F. Heyfelder (1798-1869) at the Erlangen University Hospital on January 24, 1847. Thereafter, famous discoveries occurred in the field of pharmacology. Albert Niemann isolated cocaine from the coca shrub in 1860; Emil Fischer synthesized the first barbiturate, Veronal, in 1902; and Helmut Weese promoted the first ultra-short-acting barbiturate, hexobarbital (Evipan), in 1932. The local anesthetic effect of cocaine was reported by Koller at the Congress of the German Society for Ophthalmology on September 15, 1884, in Heidelberg. Many new techniques were tried first in German hospitals. Friedrich Trendelenburg carried out, by tracheotomy, the first operation with endotracheal intubation in 1869, and Franz Kuhn promoted and clinically practiced endotracheal intubation in Heidelberg beginning in 1900. August Bier performed the first operation under spinal anesthesia at the Kiel University Hospital on August 16, 1898. Carl Ludwig Schleich (1859-1922) standardized the methods of infiltration anesthesia by using a cocaine solution in sufficient dilution. The development of anesthesia machines was greatly influenced by Heinrich Dräger (1847-1917) and his son Bernhard Dräger (1870-1928). The Dräger Company in Lübeck built the first anesthesia machine with a carbon dioxide (CO2) absorber and circle system in 1925. Paul Sudeck and Helmut Schmidt worked with this system at the Hamburg University Hospital and reported their results in 1926. The first Dräger anesthesia machine was produced in 1902 and introduced into clinical use by Otto Roth (1863-1944) in Lübeck. Before the Second World War, three universities in Germany carried out research in the field of anesthesia: the University of Freiburg with H. Killian, the University of Hamburg with P. Sudeck and H. Schmidt, and the University of Würzburg with C.G. Gauss. Killian and Gauss established the first journals, Der Schmerz and Narkose und Anaesthesie, in

  10. Neurophysiological aspects and their relationship to clinical and functional impairment in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Carolina Chiusoli de Miranda Rocco

    2011-01-01

    Full Text Available OBJECTIVE: The purpose was to assess functional (balance L-L and A-P displacement, sit-to-stand test (SST and Tinetti scale - balance and gait and neurophysiological aspects (patellar and Achilles reflex and strength relating these responses to the BODE Index. INTRODUCTION: The neurophysiological alterations found in patients with chronic obstructive pulmonary disease (COPD are associated with the severity of the disease. There is also involvement of peripheral muscle which, in combination with neurophysiological impairment, may further compromise the functional activity of these patients. METHODS: A cross-sectional study design was used. Twenty-two patients with moderate to very severe COPD (>60 years and 16 age-matched healthy volunteers served as the control group (CG. The subjects performed spirometry and several measures of static and dynamic balance, monosynaptic reflexes, peripheral muscle strength, SST and the 6-minute walk test. RESULTS: The individuals with COPD had a reduced reflex response, 36.77±3.23 (p<0.05 and 43.54±6.60 (p<0.05, achieved a lower number repetitions on the SST 19.27±3.88 (p<0.05, exhibited lesser peripheral muscle strength on the femoral quadriceps muscle, 24.98±6.88 (p<0.05 and exhibited deficits in functional balance and gait on the Tinetti scale, 26.86±1.69 (p<0.05, compared with the CG. The BODE Index demonstrated correlations with balance assessment (determined by the Tinetti scale, r = 0.59 (p<0.05 and the sit-to-stand test, r = 0.78 (p<0.05. CONCLUSIONS: The individuals with COPD had functional and neurophysiological alterations in comparison with the control group. The BODE Index was correlated with the Tinetti scale and the SST. Both are functional tests, easy to administer, low cost and feasible, especially the SST. These results suggest a worse prognosis; however, more studies are needed to identify the causes of these changes and the repercussions that could result in their activities of daily

  11. COMMITTEES: Quark Matter 2008 Organising and International Advisory Committees

    Science.gov (United States)

    2008-10-01

    Organising Committee Madan M Aggarwal (Chandigarh) Jan-e Alam (Kolkata) Convener Arup Bandyopadhyay (Kolkata) Debades Bandyopadhyay (Kolkata) Rahul Basu (Chennai) Rakesh K Bhandari (Kolkata) Anju Bhasin (Jammu) Subhasis Chattopadhyay (Kolkata) Convener Sukalyan Chattopadhyay (Kolkata) Asis Chaudhuri (Kolkata) Premomoy Ghosh (Kolkata) Sanjay Ghosh (Kolkata) Sourendu Gupta (Mumbai) Muhammad Irfan (Aligarh) Durga P Mahapatra (Bhubaneswar) DAmruta Mishra (New Delhi) Ajit K Mohanty (Mumbai) Bedangadas Mohanty (Kolkata) Vaisali Naik (Kolkata) Tapan K Nayak (Kolkata) Convener Sudhir Raniwala (Jaipur) Sourav Sarkar (Kolkata) Bikash Sinha (Kolkata) Chair Dinesh Srivastava (Kolkata) Raghava Varma (Mumbai) Yogendra P Viyogi (Bhubaneswar)Co-chair International Advisory Committee R Aymar,Switzerland Jean Paul Blaizot, France Peter Braun Münzinger, Germany Igor M Dremin, Russia Kari Eskola, Finland Jens Jorgen Gaardhoje,Denmark Rajiv V Gavai, India Hans-Ake Gustaffson, Sweden Hans Gutbrod, Germany Miklos Gyulassy, USA Timothy Hallman, USA Hideki Hamagaki, Japan Tetsuo Hatsuda, Japan Huan-Zhong Huang, USA Barbara Jacak, USA Peter Jenni, Switzerland Taka Kajino, Japan Takeshi Kodama, Brazil T D Lee, USA Peter Levai, Hungary Luciano Maiani, Italy Larry McLerran, USA Berndt Müller, USA Guy Paic, Mexico Sibaji Raha, India Lodovico Riccati, Italy Hans Georg Ritter, USA Helmut Satz, Germany Jurgen Schukraft, Switzerland Yves Schutz, France Edward V Shuryak, USA Johanna Stachel, Germany Horst Stöcker, Germany Itzhak Tserruya, Israel Xin-Nian Wang, USA Bolek Wyslouch, USA Glenn R Young, USA William A Zajc, USA Wen-Long Zhan, China

  12. [Pharmacologists in the camps In the Third Reich--part one].

    Science.gov (United States)

    Prusek, Katarzyna; Labuzek, Krzysztof; Gonciarz, Maciej; Okopień, Boguslaw

    2013-10-01

    The outbreak of World War II is considered as the inception of the pharmacology of the III Reich. Hitler's soldiers are decimated on the front lines by malaria, typhoid, gas gangrene, they need efficient and easy accessible medicines. From now on German forces are engaged into pharmacology of war. Only augmentation of Fuehrer's army effectiveness is reckoned with. Research centers in the concentrations camps are being organized, prisoners are used as the human subject. In the investigations many noted and respected personages are involved. Dr. Helmut Vetter and Dr. Ding Erwing Schuler studied chemicals which may had potential use in the prevention and treatment of typhoid. Professor Eugen Haagen carried out experiments concerning the use of vaccines against typhoid. The latter, although sentenced to life imprisonment, he returned to research in 1952 as a result of the amnesty activities in the former West Germany, and then worked as a researcher. His studies were reflected in the book, and scientific publications. Professor. Eugen Haagen died of natural causes in 1972.

  13. [Hans Franz Edmund Killian - nestor of German anesthesia : Critical appraisal on the 125th anniversary of his birth].

    Science.gov (United States)

    Brandt, L; Goerig, M; Artmeier-Brandt, U

    2017-07-11

    The surgeon Hans Killian was born on 5 August 1892 in Freiburg im Breisgau, Germany. Together with the pharmacologist Hellmut Weese and the surgeon Helmut Schmidt he was one of the nestors of modern German anesthesia. Early on during his scientific and clinical career, he addressed problems of surgical anesthesia and in 1928 he became one of the editors of the first German journal of anesthesia Narcosis and Anesthesia ("Narkose und Anästhesie"). In 1934 he published the textbook Anesthesia for Surgical Purposes ("Narkose zu operativen Zwecken"). Between World Wars I and II, he campaigned for anesthesia to become an independent medical discipline comparable to the situation in the Anglo-Saxon countries at that time. Because of his merits in the foundation of the German Society of Anesthesia on 10 April 1953 he became its first honorary member. Killian died on 7 March 1982 in Freiburg, Germany. Excerpts of his autobiography which he wrote a few years before his death and which were part of his inheritance are published here for the first time.

  14. Medizinbibliotheken: Innovativ denken, strategisch planen, praktisch umsetzen / Medical libraries: think innovative, plan strategically, implement in practice

    Directory of Open Access Journals (Sweden)

    Bauer, Bruno

    2011-12-01

    Full Text Available The focus of the current issue 3/2011 of GMS Medizin – Bibliothek – Information is the annual conference 2011 of the German Medical Libraries Association in Cologne. The motto of the conference was “Think innovative, plan strategically, implement in practice”. Focal points of the meeting were innovation management, marketing and new applications in medical libraries.The authors in this issue are Bruno Bauer, Daniel Formanek & Helmut Dollfuß (E-Books at medical libraries: They came to stay, Ursula Georgy (Systematic innovation management, Maurizio Grilli (New library portal at Province College for Health-Care Professions Claudiana, Bozen, Sabine Köhrer-Weisser (Marketing in One Person Libraries, Roland Mumenthaler (Innovation Management at ETH-Bibliothek, Markus Schmiel (Performance-related bonuses at Hannover Medical School: practical experience report of the library, Guus van den Brekel (Mobile Computing & Semantic Web in Health & Medicine, Iris Reimann & Sonja Fräntz (Think innovative, plan strategically, implement in practice – Annual Meeting 2011 of the German MLA, 19th to 21th September in Cologne and Eike Hentschel (Aus der AGMB.

  15. Elections to the Senior Staff Advisory Committee 
("The Nine") 2007

    CERN Multimedia

    2007-01-01

    The electronic voting process for the Senior Staff Advisory Committee ("The Nine") was closed on Friday 1st June. Of the 449 Senior Staff members called to vote, 281 cast a vote, of which 279 were valid. The results are as follows: Electoral Group 1 Name\tDepartment\tVotes Patrick Janot\tPH\t50 Rolf Landua\tDSU\t86 Marcello Mannelli\tPH\t22 Thomas Ruf\tPH\t30 Electoral Group 2Name\tDepartment\tVotes Olivier Brunner\tAB\t47 Doris Burckhart\tPH\t44 Helmut Burkhardt\tAB\t31 Marco Cattaneo\tPH\t48 Paul Collier\tAB\t66 Hubert Gerwig\tPH\t19 Eugenia Hatziangeli\tAB\t34 Miguel Angel Marquina\tIT\t36 Malika Meddahi\tAB\t51 Alberto Pace\tIT\t123 Stephan Russenschuck\tAT\t35 Alan Silverman\tIT\t47 Detlef Swoboda\tTS\t25 Elena Wildner\tAT\t52 Rolf Landua is therefore elected in Group 1, and Alberto Pace, Paul Collier and Elena Wildner are elected in Group 2. Their mandate is from July 2007 to June 2010. The Committee now consists of these newly-elected members together with Monica Pepe-Altarelli, Rudiger Schmidt, R. Martens, A. Unnervik and E. Tsesmelis...

  16. Cold Atmospheric Plasma for Medicine: State of Research and Clinical Application

    Science.gov (United States)

    von Woedtke, Thomas

    2015-09-01

    Basic research in plasma medicine has made excellent progress and resulted in the fundamental insights that biological effects of cold atmospheric plasmas (CAP) are significantly caused by changes of the liquid environment of cells, and are dominated by redox-active species. First CAP sources are CE-certified as medical devices. Main focus of plasma application is on wound healing and treatment of infective skin diseases. Clinical applications in this field confirm the supportive effect of cold plasma treatment in acceleration of healing of chronic wounds above all in cases where conventional treatment fails. Cancer treatment is another actual and emerging field of CAP application. The ability of CAP to kill cancer cells by induction of apoptosis has been proved in vitro. First clinical applications of CAP in palliative care of cancer are realized. In collaboration with Hans-Robert Metelmann, University Medicine Greifswald; Helmut Uhlemann, Klinikum Altenburger Land GmbH Altenburg; Anke Schmidt and Kai Masur, Leibniz Institute for Plasma Science and Technology (INP Greifswald); Renate Schönebeck, Neoplas Tools GmbH Greifswald; and Klaus-Dieter Weltmann, Leibniz Institute for Plasma Science and Technology (INP Greifswald).

  17. 1974 view into the cage of the 520 keV preaccelerator of the PS Linac 1

    CERN Multimedia

    1974-01-01

    The "open pill box" (in the background at the left) contains the ion source, where for many years all protons accelerated at CERN were "born". It is directly attached to the acceleration column where the protons pass from 520 kV to earth potential. The "electronics platform" (big metal structure on insulating pillars in the middle of the picture, for details see 7403120 and 7403071X) contains all the equipment that has to be at the same potential as the source itself. It is being admired by Helmut Haseroth and Jean Luc Vallet (during servicing). The smaller metal box in the foreground is part of the "bouncer" which compensated the voltage drop during acceleration of a proton pulse. The high voltage supply (not included in this photo) was originally a Cockcroft-Walton generator. In 1973 it was replaced by a Sames generator (see 7403074X). The "old" 50 MeV Linac 1, the original PS injector built in the 1950s, was (since 1976) replaced by a new 50 MeV linac (Linac 2). It had a 750 keV "Cockcroft-Walton" (see 760...

  18. РЕКОМЕНДАЦИИ ПО ЛЕЧЕНИЮ ОСТРОГО КОРОНАРНОГО СИНДРОМА БЕЗ СТОЙКОГО ПОДЪЕМА СЕГМЕНТА ST

    OpenAIRE

    2012-01-01

    Члены комитета по практическим рекомендациям: Jeroen J. Bax (председатель) (Нидерланды), Angelo Auricchio (Швейцария), Helmut Baumgartner (Германия), Claudio Ceconi (Италия), Veronica Dean (Франция), Christi Deaton (Великобритания), Robert Fagard (Бельгия), Christian Funck-Brentano (Франция), David Hasdai (Израиль), Arno Hoes (Нидерланды), Juhani Knuuti (Финляндия), Philippe Kolh (Бельгия), Theresa McDonagh (Великобритания),Cyril Moulin (Франция), Don Poldermans (Нидерланды), Bogdan A. Popesc...

  19. GAC-EPA

    CERN Multimedia

    GAC-EPA

    2010-01-01

    GROUPEMENT DES ANCIENS DU CERN ET DE L’ESO Le GAC organise chaque mois des permanences avec entretiens individuels. La prochaine permanence se tiendra le Mardi 7 septembre de 13h30 à 16h00 Salle de conférence de l’Association du personnel Les permanences suivantes auront lieu les mardis 5 octobre, 2 novembre et 7 décembre. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants !) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires.   Nous avons appris avec tristesse les décès de : M. Helmut Rottstock (1928), décédé le 14 juillet 2010. Il avait pris sa ret...

  20. 15. dialogue on waste management MV. Current developments in waste and resources economics. Proceedings; 15. Dialog Abfallwirtschaft MV. Aktuelle Entwicklungen in der Abfall und Ressourcenwirtschaft. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    Nelles, Michael (ed.)

    2012-07-01

    Within the 15th dialogue on waste management MV at the University of Rostock (Rostock, Federal Republic of Germany) at 13th June, 2012, the following lectures were held: (1) 20 Years GAA - 20 years of successful work (Hartwig Roessler); (2) Acquisition and evaluation of waste management data in Mecklenburg-Western Pommerania - A basis for planning for strategies according to Cycle and Waste Management Act KrWG (Helmut Kietzmann); (3) Demographic change in Mecklenburg-Western Pommerania - Implications for the waste management (Matthias Leuchter); (4) The HPWM project (Jan Marquardt); (5) Consequences of the modified legal and regulatory situation for the operation of refuse-fuelled power stations (Kurt Wengenroth); (6) Foodstuffs in the waste - Analysis and mitigation proposals (Jakob Barabosz); (7) Disposal of electric and electronic equipment as well as manufacturer responsibility (Vera Susanne Rotter); (8) Advanced waste management concepts in developing countries - foundable? Realizable? Sustainable? (Wolfgang Pfaff-Simoneit); (9) Further development of the mechanical-biological waste treatment (Stephan Schuett); (10) Airjet-pipecleaner - the automatic cleaning facility for ventilation nozzles (Armin Seidel); (11) Exploitation of reusable materials from bottom ash (Dirk Bludau); (12) Is the thermal treatment suitable for the utilization of glass-fibre reinforced plastics wastes? (Karl-Heinz Plepla); (13) Recyclability of bioplastics(An-Sophie Kitzler); (14) Development of process-oriented quality inspections for the near private collection of refuse and recyclable material (Nico Schulte).

  1. Book review: Medicinal Sponges of the Persian Gulf

    Directory of Open Access Journals (Sweden)

    Arezoo Najafi

    2012-04-01

    Full Text Available Marine sponges with about 107 genuses and more than 15000 species constitute one of the most wonderful marine invertebrates. These creatures with wide variety of biologic compounds has offered unique source of marine bioproducts towards marine researchers and chemists. Persian Gulf is habitant of various marine organisms including different species of marine sponges. The book “Medicinal sponges of the Persian Gulf” offers comprehensive review of marine bioproducts of Persian Gulf sponges. Due to limited information regarding various species of Persian gulf sponges, list of identified marine sponges of Persian gulf and Red sea that is presented in the book was collected in collaboration with Dr. Helmut Lehnert from Germany, Dr. Rob Van Soest from Amsterdam university and Dr. Jochen Gugel from Stuttgart university. Derivatives of about 55 genuses and 28 species of Persian Gulf sponges were found to be bioactive through searching medical databases and are reviewed in different chapters of the book. Cytotoxic and antitumor compounds constitute the most products derived from Persian Gulf sponges. The review explores Persian gulf sponges as a natural pharmacy with potential pharmaceutical derivatives in near future and indicates further need for investigation of Persian gulf marine organisms’ for bioactive products.

  2. Conference: ActiWiz – Optimizing material selection at CERN's accelerators from the radiological point of view

    CERN Multimedia

    2012-01-01

    by Dr. Helmut Vincke (CERN), Chris Theis (CERN). Tuesday, October 30, 2012 from 15:00 to 16:30 at CERN ( 864-1-D02 - BE Auditorium Prévessin ) Description: The operation of a high-energy accelerator inevitably triggers the activation of equipment, which poses a safety hazard. Consequently access and handling constraints have to be imposed to ensure optimized working conditions. One of the key parameters determining the level of radioactivity is the material composition. Considering the radiological impact in addition to the engineering requirements during the selection of material clearly results in a safety benefit as well as a more efficient accelerator operation due to less stringent access and handling constraints. Another aspect is the minimization of future radioactive waste, which constitutes an important part of CERN’s commitment to limit its environmental impact by applying best practices. The ActiWiz software developed at CERN provides an easy to use method to optimize the m...

  3. Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle

    Directory of Open Access Journals (Sweden)

    Andreas Rank

    2010-05-01

    Full Text Available Andreas Rank, Oliver Weigert, Helmut OstermannMedizinische Klinik III – Grosshadern, Klinikum der Ludwig Maximilians-Universitaet Munich, Munich, GermanyAbstract: Traditionally, anti-platelet autoantibodies accelerating platelet clearance from the peripheral circulation have been recognized as the primary pathopysiological mechanism in chronic immune thrombocytopenia (ITP. Recently, increasing evidence supports the co-existence of insufficient megakaryopoiesis. Inadequate low thrombopoietin (TPO levels are associated with insufficient proliferation and differentiation of megakaryocytes, decreased proplatelet formation, and subsequent platelet release. Recently two novel activators of TPO receptors have been made available: romiplostim and eltrombopag. In several phase III studies, both agents demonstrated increase of platelet counts in about 80% of chronic ITP patients within 2 to 3 weeks. These agents substantially broaden the therapeutic options for patients with chronic ITP although long-term results are still pending. This review will provide an update on the current conception of underlying mechanisms in ITP and novel, pathophysiologically based treatment options.Keywords: immune thrombocytopenia, romiplostim, eltrombopag, megakaryopoiesis

  4. Medizinbibliotheken – Konstant im Wandel

    Directory of Open Access Journals (Sweden)

    Bauer, Bruno

    2013-12-01

    Full Text Available [english] The focus of the current issue 3/2013 of GMS Medizin – Bibliothek – Information is the annual conference 2013 of the German Medical Libraries Association in Berlin. The motto of the conference was “Medical libraries – Change is the constant”. The authors in this issue are Michaele Adam (Open access publishing in medicine – in the focus of bibliometrics at the SLUB Dresden, Bruno Bauer, Helmut Dollfuß & Daniel Formanek (The university library at the Medical University Vienna goes e-only. Change in the provision of literature from p+e to e-only on January 1, 2013, Henriette Senst & Jens Erling (The teaching services of the Robert Koch-Institute’s library and Martina Semmler-Schmetz & Jutta Matrisciano (Medical Libraries – Change is the Constant. Annual meeting 2013 of the German MLA (AGMB, September 16 to 18 in Berlin.Furthermore this focus issue features articles from Oliver Obst & Verena Salewsky (How do today’s students learn? An e-book study of the branch library of medicine, University of Münster and from Oliver Obst, Christiane Hofmann, Helge Knüttel & Petra Zöller (“Ask a question, get an answer, continue your work!” – Survey on the use of UpToDate at the universities of Freiburg, Leipzig, Münster and Regensburg.

  5. Empresários e ação coletiva: notas para um enforque relativo

    Directory of Open Access Journals (Sweden)

    Álvaro Bianchi

    2007-06-01

    Full Text Available Este artigo esboça um enfoque teórico relacional para o estudo da ação coletiva empresarial. Para tal, argumenta-se que tanto o individualismo metodológico de Mancur Olson como a análise sociológica das classes sociais de Claus Offe e Helmut Wiesenthal, enfoques amplamente difundidos nos estudos sobre o empresariado, apresentam uma forte tendência essencialista. Tal tendência tende a substituir o conflito social por determinismos de vários tipos - econômicos, culturais, psicológico etc. Em contraposição a estes enfoques, é esboçada uma abordagem relacional na qual a ação coletiva empresarial é o resultado das relações de forças existentes, destacando a dimensão conflitiva e histórica do processo de construção da ação e da organização coletiva. Para o estudo das associações empresariais, esta perspectiva permite pensá-las como resultado dos conflitos sociais e de lugar.

  6. The place of the 17th century in Jung's encounter with China.

    Science.gov (United States)

    Cambray, Joe

    2005-04-01

    After recounting several dreams and related alchemical interests of Jung's tied to the 17(th) century, a contextualizing look at select scientific and philosophical developments of that century is presented. Several precursors of the contemporary debates on the mind/body relation are noted, with special reference to the work of Antonio Damasio. This in turn leads to a reconsideration of the work of the 17(th) century polymath Gottfried Wilhelm Leibniz, which Jung read as a major precursor to his formulation of synchronicity (via Leibniz's concept of 'pre-established harmony'). Leibniz was the first philosopher to articulate the mind/body relationship in terms of supervenience, sharing an accord with those contemporary philosophers and scientists who see the mind as being an emergent property of the body-brain. Similarly, these ideas are also consistent with a reformulation of synchronicity in terms of emergence. Tracing Leibniz's interest in China reveals another set of links to Jung and to emergentism. Jung's use of Taoist concepts in developing the synchronicity principle is well known. According to scholars, Leibniz was the first major Western intellect to study the I-Ching, through the assistance of a Jesuit missionary in Beijing, Fr. Joachim Bouvet. Some details of the Leibniz-Bouvet correspondence are discussed here. Despite Helmut Wilhelm's presenting aspects of this correspondence at an Eranos conference, Jung does not appear to have integrated it into his writing on synchronicity--a possible reason for this omission is suggested.

  7. The speech choir in central European theatres and literary-musical works in the first third of the 20th century

    Directory of Open Access Journals (Sweden)

    Meyer-Kalkus Reinhart

    2015-01-01

    Full Text Available Speech choirs emerged as an offshoot of the choral gatherings of a wider youth musical and singing movement in the first half of the 20th century. The occasionally expressed opinion that choral speaking was cultivated primarily by the Hitler Youth and pressed into service on behalf of Nazi nationalist and racist propaganda is, historically, only partially accurate. The primary forces of choral speaking in Germany were, from 1919, the Social Democratic workers’ and cultural movement and the Catholic youth groups, in addition to elementary and secondary schools. The popularity of speech choirs around 1930 was also echoed in the music of the time. Compositions for musical speech choirs were produced by composers like Heinz Thiessen, Arnold Schönberg, Ernst Toch, Carl Orff, Vladimir Vogel, Luigi Nono, Helmut Lachenmann and Wolfgang Rihm. Moving forward from the Schönberg School, the post-1945 new music thereby opens up the spectrum of vocal expressions of sound beyond that of the singing voice. It does so not only for solo voices but for the choir as well.

  8. Werner Heisenberg - Life and Work

    CERN Multimedia

    2002-01-01

    Werner Heisenberg (centre) with Wolfgang Pauli (left) and Enrico Fermi on Lake Como, September 1927. An exhibition on the life and work of Werner Heisenberg will be on display in the Main Building (Mezzanine) at CERN from 1 - 23 July. The exhibition was produced by the University Archive of Leipzig University (Gerald Wiemers) and the Max-Planck-Institut für Physik in Munich (Helmut Rechenberg) to mark the centenary of Heisenberg's birth in 1901. German theoretical physicist Werner Karl Heisenberg (5 December 1901 - 1 February 1976) was one of the leading scientists of the 20th century. He carried out important work in nuclear and particle physics, but his most significant contribution was to the development of quantum mechanics. He is best known for his uncertainty principle, which restricts the accuracy with which some properties of atoms and particles - such as position and linear momentum - can be determined simultaneously. In 1932 he was awarded the Noble Prize in Physics 'for the creation of q...

  9. Werner Heisenberg - Life and Work

    CERN Document Server

    2002-01-01

    Werner Heisenberg (centre) with Wolfgang Pauli and Enrico Fermi, 1927. An exhibition on the life and work of Werner Heisenberg will be on display in the Main Building (Mezzanine) at CERN from 1 - 30 July*. German theoretical physicist Werner Karl Heisenberg (1901 - 1976) was one of the leading scientists of the 20th century. Nobel Prize in Physics in 1932, his most significant contribution was to the development of quantum mechanics. He is best known for his uncertainty principle, which restricts the accuracy with which some properties of atoms and particles can be determined simultaneously. Heisenberg was a keen supporter of CERN, and was as the first chairman of CERN's Scientific Policy Committee in October 1954. A related celebration will take place in the TH Amphitheatre (4/3-006), on Thursday 18 July at 16:00. After an introduction from the Director-General Luciano Maiani, his daughter, Barbara Blum, his last postgraduate, Helmut Rechenberg and Valentin Telegdi will evoke memories of the life and work ...

  10. Analysis of the article: the economics of wind energy within the generation mix; Analyse de l'article: the economics of wind energy within the generation mix

    Energy Technology Data Exchange (ETDEWEB)

    Bacher, P

    2006-11-15

    The author discusses the paper of Helmut Alt, published in the International Journal Energy Technology and Policy, in 2005. With more than 15,000 plants of different capacity ranges, Germany has become the world's No. 1 in generating electricity from wind power, covering around 4% of the electricity requirements at home. This is due on the one hand to the successful promotion by the Renewable Energy Act (EEG) and, on the other hand, to the tax breaks from loss allocation and depreciation. During low-load periods, load dispatchers today already have to balance power gradients of more than 10% of the respective network load per minute, which are increasingly covered by the provision of balancing power from conventional power plants. The legally fixed permanent subsidy burden of the electricity industry due to the high compensation fee for wind power alone currently amounts to? 1.4 billion a year. If base load capacity from nuclear power plants is replaced in the medium term, this will not reduce but rather increase CO{sub 2} emissions as generation from gas turbines will have to be increased temporarily in times of flagging winds. (A.L.B.)

  11. Adding Gestalt to the picture. Comment on "Move me, astonish me…" delight my eyes and brain: The Vienna Integrated Model of top-down and bottom-up processes in Art Perception (VIMAP) and corresponding affective, evaluative, and neurophysiological correlates; by Matthew Pelowski et al.

    Science.gov (United States)

    Wagemans, Johan

    2017-07-01

    Matthew Pelowski and his colleagues from the Helmut Leder lab [17] have made a remarkable contribution to the field of art perception by reviewing the extensive and varied literature (+300 references) on all the factors involved, from a coherent, synthetic perspective-The Vienna Integrated Model of top-down and bottom-up processes in Art Perception (VIMAP). VIMAP builds on earlier attempts from the same group to provide a comprehensive theoretical framework, but it is much wider in scope and richer in the number of levels and topics covered under its umbrella. It is particularly strong in its discussion of the different psychological processes that lead to a wide range of possible responses to art-from mundane, superficial reactions to more profound responses characterized as moving, disturbing, and transformative. By including physiological, emotional, and evaluative factors, the model is able to address truly unique, even intimate responses to art such as awe, chills, thrills, and the experience of the sublime. The unique way in which this rich set of possible responses to art is achieved is through a series of five mandatory consecutive processing steps (each with their own typical duration), followed by two conditional additional steps (which take more time). Three processing checks along this cascade lead to three more or less spontaneous outcomes (art, testing specific hypotheses derived from this framework for decades to come.

  12. Teaching Library: Vermittlung von Informationskompetenz an medizinischen Bibliotheken

    Directory of Open Access Journals (Sweden)

    Bauer, Bruno

    2014-08-01

    Full Text Available [english] The focus of the current issue 1-2/2014 of GMS Medizin – Bibliothek – Information is on “Teaching Library: information literacy instruction at medical libraries”. The authors in this issue are Marina Betker & Annette Kustos (Literature research training in health sciences in a new academic library – straight through and strategic planning: the concept of the “hsg Bochum”, Simone Waldboth (Integration of e-learning in the lecture “Information Literacy” at the Provincial College for Health-Care Professions „Claudiana“, Michaele Adam & Jens Mittelbach (Shaping the Future at the SLUB Dresden with Information Literacy in the Research Cycle, Gregor Steinrisser (Sucessfully failing – Fiction and Friction of a teaching library in university and clinical daily routine, Melanie Kintzel & Norbert Sunderbrink (Information literacy classes at the Medical Library of the University Medical Center Hamburg-Eppendorf, Markus Schmiel (The teaching and learning concept of the Library of the Hannover Medical School, Jutta Matrisciano & Martina Semmler-Schmetz (Teaching Library – Realization of a concept with many facets at the Library for the Medical Faculty of Mannheim, Karin Cepicka („Teaching Library“ at the Library oft the Medical University Vienna, Helmut Dollfuß (Library user education for the new curriculum at the Medical University Vienna, Manuela Rohrmoser & Irene Schachl (The cooperations of teaching librarians at Vienna University Library und Claudia Hausberger & David Frank (Curriculum reform – a work report from the Library of the University of Veterinary Medicine Vienna.

  13. Melting hadrons, boiling quarks from Hagedorn temperature to ultra-relativistic heavy-ion collisions at CERN : with a tribute to Rolf Hagedorn

    CERN Document Server

    2015-01-01

    This book shows how the study of multi-hadron production phenomena in the years after the founding of CERN culminated in Hagedorn's pioneering idea of limiting temperature, leading on to the discovery of the quark-gluon plasma - announced, in February 2000 at CERN. Following the foreword by Herwig Schopper -- the Director General (1981-1988) of CERN at the key historical juncture -- the first part is a tribute to Rolf Hagedorn (1919-2003) and includes contributions by contemporary friends and colleagues, and those who were most touched by Hagedorn: Tamás Biró, Igor Dremin, Torleif Ericson, Marek Gázdzicki, Mark Gorenstein, Hans Gutbrod, Maurice Jacob, István Montvay, Berndt Müller, Grazyna Odyniec, Emanuele Quercigh, Krzysztof Redlich, Helmut Satz, Luigi Sertorio, Ludwik Turko, and Gabriele Veneziano. The second and third parts retrace 20 years of developments that after discovery of the Hagedorn temperature in 1964 led to its recognition as the melting point of hadrons into boiling quarks, and t...

  14. The ecological consequences of temperament in spiders

    Directory of Open Access Journals (Sweden)

    Jonathan N. PRUITT, Susan E. RIECHERT

    2012-08-01

    Full Text Available Ecological and evolutionary studies on spiders have been featured prominently throughout the contemporary behavio­ral syndromes movement. Here we review the behavioral syndromes literature devoted to spiders, and identify some ways in which behavioral syndromes can impact the function of spiders in ecological communities. We further highlight three general themes within the behavioral syndromes literature for which spiders have served as front running model systems: (1 how trait correlations beget performance trade-offs, (2 the influence that behavioral trait variants have on interspecific interactions and (3 mechanisms that aid in maintaining behavioral variation within- and among-populations. Research on behavioral syndromes continues to grow at an impressive rate, and we feel the success of behavioral syndromes studies in spiders bodes well for their continued prominence [Current Zoology 58 (4: 589–596, 2012].

  15. Bioethanol Production from Waste Potatoes as a Sustainable Waste-to-energy Resource via Enzymatic Hydrolysis

    Science.gov (United States)

    Memon, A. A.; Shah, F. A.; Kumar, N.

    2017-07-01

    Ever increasing demand of energy and corresponding looming depletion of fossil fuels have transpired into a burning need of time to vie for alternative energy resources before the traditional energy sources are completely exhausted. Scientists are continuously working on sustainable energy production as an alternate source of energy to meet the present and future requirements. This research deals with conversion of the starch to fermentable carbon source (sugars) by fermentation through liquefaction by using yeast and alpha- amylase. The results show that the significant bioethanol production was achieved while using the parameters like temperature (30 °C) pH (6) and incubation time of 84 hrs. About 90 ml of bioethanol was produced from potato intake of 800 g. Pakistan being an agricultural country is rich in potato crop and this research bodes well to open new vistas to arrest the energy shortage in this part of the world

  16. Students want feedback and educators need dialogue

    DEFF Research Database (Denmark)

    Esbjerg, Lars; Rask, Morten

    2015-01-01

    wanting: a survey found that only a third of students at Business and Social Science (BSS), Aarhus University (AU), think they get sufficient feedback on their work , while educators bemoan the impossibility of activating and engaging students in the substantive, theoretical and methodological discussions...... in class-room settings that are considered central for effective learning. In other words, we have a situation where students want to talk to their teachers and teachers also want to engage in dialogue, but they seem to get nowhere. Based on qualitative and quantitative data from both students......We discuss what we call “the interaction paradox” in Danish management education. On the one hand, the fact that students want more feedback and educators want to foster dialogue with their students should bode well for interaction in educational settings. On the other hand, both groups are left...

  17. Minimal elastographic modeling of breast cancer for model based tumor detection in a digital image elasto tomography (DIET) system

    Science.gov (United States)

    Lotz, Thomas F.; Muller, Natalie; Hann, Christopher E.; Chase, J. Geoffrey

    2011-03-01

    Digital Image Elasto Tomography (DIET) is a non-invasive breast cancer screening technology that images the surface motion of a breast under harmonic mechanical actuation. A new approach capturing the dynamics and characteristics of tumor behavior is presented. A simple mechanical model of the breast is used to identify a transfer function relating the input harmonic actuation to the output surface displacements using imaging data of a silicone phantom. Areas of higher stiffness cause significant changes of damping and resonant frequencies as seen in the resulting Bode plots. A case study on a healthy and tumor silicone breast phantom shows the potential for this model-based method to clearly distinguish cancerous and healthy tissue as well as correctly predicting the tumor position.

  18. Local order origin of thermal stability enhancement in amorphous Ag doping GeTe

    Science.gov (United States)

    Xu, L.; Li, Y.; Yu, N. N.; Zhong, Y. P.; Miao, X. S.

    2015-01-01

    We demonstrate the impacts of Ag doping on the local atomic structure of amorphous GeTe phase-change material. The variations of phonon vibrational modes, boding nature, and atomic structure are shown by Raman, X-ray photoelectron spectroscopy, and ab initio calculation. Combining the experiments and simulations, we observe that the number of Ge atoms in octahedral site decreases and that in tetrahedral site increases. This modification in local order of GeTe originating from the low valence element will affect the crystallization behavior of amorphous GeTe, which is verified by differential scanning calorimetry and transmission electron microscope results. This work not only gives the analysis on the structural change of GeTe with Ag dopants but also provides a method to enhance the thermal stability of amorphous phase-change materials for memory and brain-inspired computing applications.

  19. Effect of dc-bias on the dielectric behavior of CNT/ABS nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    El Ghanem, Hasan M., E-mail: hmel@just.edu.jo [Physics Department, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110 (Jordan); Abdul Jawad, Saa' di [Physics Department, Hashemite University, P.O. Box 150459, Zarqa 13115 (Jordan); Al-Saleh, Mohammed H.; Hussain, Yazan A [Department of Chemical Engineering, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110 (Jordan); Salah, Wael [Physics Department, Hashemite University, P.O. Box 150459, Zarqa 13115 (Jordan)

    2013-06-01

    Several aspects of the dielectric behavior of multi-walled carbon nanotube (MWCNT)/acrylonitrile–butadiene–styrene (ABS) nanocomposites were studied. MWCNT/ABS nanocomposites with filler content between 2 wt% and 15 wt% were prepared by melt mixing and characterized by the impedance technique. The results showed that the dc and ac conductivities increase with increasing dc bias and MWCNT content. The effect of dc bias was more pronounced for nanocomposites with low MWCNT content. The bode diagram of the real impedance for nanocomposites containing 2 wt% MWCNT or higher exhibited a frequency independent plateau in the low frequency region revealing that dc conduction is the dominant conduction mechanism. The critical frequency at which ac conductivity becomes frequency dependent increased with increasing dc bias and MWCNT content.

  20. Pharmacy students' approaches to learning in undergraduate and graduate entry programs.

    Science.gov (United States)

    Smith, Lorraine; Krass, Ines; Sainsbury, Erica; Rose, Grenville

    2010-08-10

    To compare longitudinal data with previous cross-sectional data regarding Australian undergraduate pharmacy students' approaches to learning, and explore the differences in approaches to learning between undergraduate and postgraduate cohorts. Longitudinal, repeated measures design using a validated self-report survey instrument were used to gather data. Undergraduate students' preferences for meaning directed, undirected, and reproduction-directed approaches to learning displayed the same pattern across the 2 studies; however, application-directed scores increased significantly in the second half of the undergraduate degree program. Commencing postgraduate students' approaches to learning were similar to finishing undergraduate students, and this group was significantly more oriented towards meaning-directed learning compared to undergraduate students. Pharmacy students' maturation in approach to their learning was evident and this bodes well for pharmacists' engaging in life-long learning and capacity to work in increasingly complex health settings.

  1. Analysis of the Behavior of Undamped and Unstable High-Frequency Resonance in DFIG System

    DEFF Research Database (Denmark)

    Song, Yipeng; Blaabjerg, Frede

    2017-01-01

    the Bode diagram as an analysis tool. However, the HFR can be categorized into two different types: undamped HFR (which exists in steady state) and unstable HFR (which eventually results in complete instability and divergence), both of them are not investigated before. Since both the undamped HFR...... and unstable HFR are critical to the output wind power quality as well as the safe and reliable operation of the DFIG system, it is meaningful to discuss them using the Nyquist Criterion from two perspectives, 1) determining either the undamped HFR or the unstable HFR happens; 2) estimating the amplitude...... of the undamped HFR. The influence factors, including the weak network shunt capacitance, the current PI controller parameters are discussed when estimating the amplitude of the undamped HFR. The experimental and simulation results of a 7.5 kW down-scaled DFIG setup are provided to validate the analysis...

  2. Improvement of a high current DC power supply system for testing the large scaled superconducting cables and magnets

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Shuichi; Chikaraishi, Hirotaka; Tanahashi, Shugo [and others

    1993-11-01

    A dc 75 kA power supply system was constructed to test the superconducting (SC) R and D cables and magnets for the Large Helical Device. It consists of three 25 kA unit banks. A unit bank has two double-star-rectifier connections with the inter-phase reactors. A digital feedback control method is applied to the automatic current regulation (ACR) in each unit bank. For shortening the dead time of the feedback process, a new algorithm of a digital phase controller for the ACR is investigated. A Bode diagram of the feedback process is directly measured. It is confirmed that the dead time of the feedback process is reduced to one sixth, and that the feedback gain of PID compensation is improved by a factor of two from the original method. (author).

  3. Improvement of a high current dc power supply system for testing the large scaled superconducting cables and magnets

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Shuichi; Chikaraishi, Hirotaka; Tanahashi, Shugo [National Inst. for Fusion Science, Toki, Gifu (Japan)] [and others

    1994-07-01

    A dc 75 kA power supply system was constructed to test the SC (superconducting) R and D (research and development) cables and magnets for the Large Helical Device (LHD). It consists of three 25 kA unit banks. A unit bank has two double-star-rectifier connections with the inter-phase reactors. A digital feedback control method is applied to the automatic current regulation (ACR) in each unit bank. For shortening the dead time of the feedback process, a new algorithm of a digital phase controller for the ACR is investigated. A Bode diagram of the feedback process is directly measured. It is confirmed that the dead time of the feedback process is reduced to one sixth, and that the feedback gain of PID (proportional, integral and differential) compensation is improved by a factor of two from the original method.

  4. The 9th International Countercurrent Chromatography Conference held at Dominican University, Chicago, USA, August 1-3, 2016.

    Science.gov (United States)

    Friesen, J Brent; McAlpine, James B; Chen, Shao-Nong; Pauli, Guido F

    2017-10-20

    The 9th International Countercurrent Chromatography Conference (CCC 2016) was held at Dominican University near Chicago, IL (USA), from August 1st-3rd, 2016. The biennial CCC 20XX conferences provide an opportunity for countercurrent chromatography and centrifugal partition chromatography (CCC/CPC) manufactures, marketers, theorists, and research scientists to gather together socially, learn from each other, and advance countercurrent separation technology. A synopsis of the conference proceedings as well as a series of short reviews of the special edition articles is included in this document. Many productive discussions and collegial conversation at CCC 2016 attested to the liveliness, connectivity, and productivity of the global countercurrent research community and bodes well for the success of the 10th conference at the University of Braunschweig, Germany on August 1-3, 2018. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Herbs as new type of green inhibitors for acidic corrosion of steel

    Energy Technology Data Exchange (ETDEWEB)

    Khamis, E. [Faculty of Science, Chemistry Department, Alexandria University, P.O. Box 426 Ibrahimia Alexandria 21321 (Egypt); AlAndis, N. [College of Science, Chemistry Department, King Saud University (Saudi Arabia)

    2002-09-01

    Corrosion inhibition of steel in sulphuric acid by six different herb plants has been studied using a.c and d.c electrochemical techniques. The environmentally friendly investigated compounds are namely: thyme, coriander, hibiscus, anis, black cumin and Garden cress. Electrochemical impedance spectroscopy has been successfully used to evaluate the performance of these compounds. The ac measurements showed that the dissolution process is activation controlled. Bode and theta diagrams show only one time constant ({tau}). Potentiodynamic polarization curves indicate that the studied compounds are mixed-type inhibitors. The order of increasing inhibition efficiency was correlated with the change of the constituent active materials of the compounds. Thyme, which contains the powerful antiseptic thymol as the active ingredient, offers excellent protection for steel surface. (Abstract Copyright [2002], Wiley Periodicals, Inc.)

  6. REMPI Spectroscopy of HfF

    CERN Document Server

    Loh, Huanqian; Yahn, Tyler S; Looser, Herbert; Field, Robert W; Cornell, Eric A

    2012-01-01

    The spectrum of electronic states at 30000--33000 cm$^{-1}$ in hafnium fluoride has been studied using (1+1) resonance-enhanced multi-photon ionization (REMPI) and (1+1$'$) REMPI. Six $\\Omega' = 3/2$ and ten $\\Pi_{1/2}$ vibronic bands have been characterized. We report the molecular constants for these bands and estimate the electronic energies of the excited states using a correction derived from the observed isotope shifts. When either of two closely spaced $\\Pi_{1/2}$ electronic states is used as an intermediate state to access autoionizing Rydberg levels, qualitatively distinct autoionization spectra are observed. The intermediate state-specificity of the autoionization spectra bodes well for the possibility of using a selected $\\Pi_{1/2}$ state as an intermediate state to create ionic HfF$^+$ in various selected quantum states, an important requirement for our electron electric dipole moment (eEDM) search in HfF$^+$.

  7. The European Union Training Mission in Mali: A case study

    Directory of Open Access Journals (Sweden)

    Dicke Rachel

    2014-10-01

    Full Text Available For several years, the European Union (EU has been increasing its international presence and moving into the role of a global security actor. To support the goal of greater crisis management capabilities, European security integration (ESI has been deepening. This article therefore examines an Ell operation - the European Union Training Mission in Mali (EUTM Mali - with the aim of gauging the success of the EU's efforts at ESI. To determine the success of EUTM Mali and thus of ESI, three propositions are examined: if EUTM Mali is a security operation showing successful security integration, there will be evidence of (i broad participation, (ii financial burden-sharing and (iii the successful incorporation of troops and equipment. The first and third propositions are supported whereas the second does not receive as much support. Overall, EUTM Mali shows considerable success and bodes well for further ESI.

  8. High Temperature Materials Laboratory Fourteenth Annual Report: October 2000 through September 2001

    Energy Technology Data Exchange (ETDEWEB)

    Pasto, A.E.

    2002-05-16

    The HTML User Program continued to work with industrial, academic, and governmental users this year, accepting 92 new projects and developing 48 new user agreements. Table 1 presents the breakdown of these statistics. Figure 1 depicts the continued growth in user agreements and user projects. You will note that the total number of HTML proposals has now exceeded 1000. Also, the large number of new agreements bodes well for the future. At the end of the report, we present a list of proposals to the HTML and a list of agreements between HTML and universities and industries, broken down by state. Program highlights this year included several outstanding user projects (some of which are highlighted in later sections), the annual meeting of the HTML Programs Senior Advisory Committee, and approval by ORNL for the construction of a building to house our new aberration-corrected electron microscope (ACEM) and several other sensitive electron and optical instruments.

  9. Controlling the electrodeposition, morphology and structure of hydroxyapatite coating on 316L stainless steel.

    Science.gov (United States)

    Thanh, Dinh Thi Mai; Nam, Pham Thi; Phuong, Nguyen Thu; Que, Le Xuan; Anh, Nguyen Van; Hoang, Thai; Lam, Tran Dai

    2013-05-01

    Hydroxyapatite (HAp) coatings were prepared on 316L stainless steel (316LSS) substrates by electrochemical deposition in the solutions containing Ca(NO3)2·4H2O and NH4H2PO4 at different electrolyte concentrations. Along with the effect of precursor concentration, the influence of temperature and H2O2 content on the morphology, structure and composition of the coating was thoroughly discussed with the help of X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectra. The in vitro tests in simulated body fluids (SBF) were carried out and then the morphological and structural changes were estimated by SEM and electrochemical techniques (open circuit potential, polarization curves, Nyquist and Bode spectra measurements). Being simple and cost-effective, this method is advantageous for producing HAp implant materials with good properties/characteristics, aiming towards in vivo biomedical applications. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. Analytical design of fractional-order proportional-integral controllers for time-delay processes.

    Science.gov (United States)

    Vu, Truong Nguyen Luan; Lee, Moonyong

    2013-09-01

    A new design method of fractional-order proportional-integral controllers is proposed based on fractional calculus and Bode's ideal transfer function for a first-order-plus-dead-time process model. It can be extended to be applied to various dynamic models. Tuning rules were analytically derived to cope with both set-point tracking and disturbance rejection problems. Simulations of a broad range of processes are reported, with each simulated controller being tuned to have a similar degree of robustness in terms of resonant peak to other reported controllers. The proposed controller consistently showed improved performance over other similar controllers and established integer PI controllers. Copyright © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

  11. Classical controller design techniques for fractional order case.

    Science.gov (United States)

    Yeroglu, Celaleddin; Tan, Nusret

    2011-07-01

    This paper presents some classical controller design techniques for the fractional order case. New robust lag, lag-lead, PI controller design methods for control systems with a fractional order interval transfer function (FOITF) are proposed using classical design methods with the Bode envelopes of the FOITF. These controllers satisfy the robust performance specifications of the fractional order interval plant. In order to design a classical PID controller, an optimization technique based on fractional order reference model is used. PID controller parameters are obtained using the least squares optimization method. Different PID controller parameters that satisfy stability have been obtained for the same plant. Copyright © 2011 ISA. Published by Elsevier Ltd. All rights reserved.

  12. Educating and Inspiring Young People for the Next Generation of Exploration

    Science.gov (United States)

    Armstrong, Robert C., Jr.

    2007-01-01

    With the graying of the nation's scientific workforce and the decline in students pursuing science, technological, engineering, and math related-studies, real challenges lie ahead if America is to continue to sustain the Vision for Space Exploration in the foreseeable future. Likewise, challenges exist in the economic arena as the United States seeks to maintain its preeminence among the technological leaders of the world. Currently, less than 6 percent of high school seniors are pursuing engineering degrees, down from 36 percent a decade ago. Today, China produces six times as many engineers as does the United States and Japan, at half our population, develops twice as many engineers. Despite spending more per capita on public education than any other nation, except Switzerland, U.S. students of high school age are failing to compete with many foreign countries. These trends do not bode well for America's future competitiveness in space and other technically driven areas, such as defense.

  13. Stability of fractional quantum Hall states in disordered photonic systems

    Science.gov (United States)

    DeGottardi, Wade; Hafezi, Mohammad

    2017-11-01

    The possibility of realizing fractional quantum Hall liquids in photonic systems has attracted a great deal of interest of late. Unlike electronic systems, interactions in photonic systems must be engineered from nonlinear elements and are thus subject to positional disorder. The stability of the topological liquid relies on repulsive interactions. In this paper we investigate the stability of fractional quantum Hall liquids to impurities which host attractive interactions. Employing the Bose–Hubbard model with a magnetic field, we find that for sufficiently strong attractive interactions these impurities can destroy the topological liquid. However, we find that the liquid is quite robust to these defects, a fact which bodes well for the realization of topological quantum Hall liquids in photonic systems.

  14. Analysis and design of segment control system in segmented primary mirror

    Science.gov (United States)

    Yu, Wenhao; Li, Bin; Chen, Mo; Xian, Hao

    2017-10-01

    Segmented primary mirror will be adopted widely in giant telescopes in future, such as TMT, E-ELT and GMT. High-performance control technology of the segmented primary mirror is one of the difficult technologies for telescopes using segmented primary mirror. The control of each segment is the basis of control system in segmented mirror. Correcting the tilt and tip of single segment is the main work of this paper which is divided into two parts. Firstly, harmonic response done in finite element model of single segment matches the Bode diagram of a two-order system whose natural frequency is 45 hertz and damping ratio is 0.005. Secondly, a control system model is established, and speed feedback is introduced in control loop to suppress resonance point gain and increase the open-loop bandwidth, up to 30Hz or even higher. Corresponding controller is designed based on the control system model described above.

  15. A Meta-Model of Inter-Organisational Cooperation for the Transition to a Circular Economy

    Directory of Open Access Journals (Sweden)

    Alessandro Ruggieri

    2016-11-01

    Full Text Available The transition to a circular economy bodes well for a future of environmentally sustainable growth and economic development. The implications and advantages of a shift to a circular economy have been extensively demonstrated by the literature on the subject. What has not been sufficiently investigated is how this paradigm can be enabled through the inter-organisational cooperation among different business enterprises. In order to illustrate this point, in this paper we aim to contribute to the circular economy debate by describing and discussing such a meta-model of inter-organisational cooperation. The present study is therefore based on the analysis of three cases from an equal number of industries, from which we identified factors of potential impact for the stimulation of cooperation in a circular economy perspective. Last, but not least, we discuss the relations between the case studies and try to formulate all possible implications for both managers and research.

  16. Fundamental limitations in filtering and control

    CERN Document Server

    Seron, Maria M

    1997-01-01

    The issue of fundamental limitations in filtering and control lies at the very heart of any feedback system design, since it reveals what is and is not achievable on the basis of that system's structural and dynamic characteristics. Alongside new succinct treatments of Bode's original results from the 1940s, this book presents a comprehensive analysis of modern results, featuring contemporary developments in multivariable systems, sampled-data, periodic and nonlinear problems. The text gives particular prominence to sensitivity functions which measure the fundamental qualities of the system, including performance and robustness. With extensive appendices covering the necessary background on complex variable theory, this book is an ideal self-contained resource for researchers and practitioners in this field.

  17. Calculations of secondary electron yield of graphene coated copper for vacuum electronic applications

    Directory of Open Access Journals (Sweden)

    H. K. A. Nguyen

    2018-01-01

    Full Text Available The suppression of secondary electron yield (SEY which can possibly lead to multipactor is an important goal for several applications. Though some techniques have focused on geometric modifications to lower the SEY, the use of graphene coatings as thin as a few monolayers is a promising new development that deserves attention either as a standalone technique or in concert with geometric alterations. Here we report on Monte Carlo based numerical studies of SEY on graphene coated copper with comparisons to recent experimental data. Our predicted values are generally in good agreement with reported measurements. Suppression of the secondary electron yield by as much as 50 percent (over copper with graphene coating is predicted at energies below 125 eV, and bodes well for multipactor suppression in radio frequency applications.

  18. Calculations of secondary electron yield of graphene coated copper for vacuum electronic applications

    Science.gov (United States)

    Nguyen, H. K. A.; Mankowski, J.; Dickens, J. C.; Neuber, A. A.; Joshi, R. P.

    2018-01-01

    The suppression of secondary electron yield (SEY) which can possibly lead to multipactor is an important goal for several applications. Though some techniques have focused on geometric modifications to lower the SEY, the use of graphene coatings as thin as a few monolayers is a promising new development that deserves attention either as a standalone technique or in concert with geometric alterations. Here we report on Monte Carlo based numerical studies of SEY on graphene coated copper with comparisons to recent experimental data. Our predicted values are generally in good agreement with reported measurements. Suppression of the secondary electron yield by as much as 50 percent (over copper) with graphene coating is predicted at energies below 125 eV, and bodes well for multipactor suppression in radio frequency applications.

  19. Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids.

    Science.gov (United States)

    Przybyłek, Maciej; Ziółkowska, Dorota; Mroczyńska, Karina; Cysewski, Piotr

    2016-03-31

    The cocrystallization of salicylamide (2-hydroxybenzamide, SMD) and ethenzamide (2-ethoxybenzamide, EMD) with aromatic carboxylic acids was examined both experimentally and theoretically. The supramolecular synthesis taking advantage of the droplet evaporative crystallization (DEC) technique was combined with powder diffraction and vibrational spectroscopy as the analytical tools. This led to identification of eleven new cocrystals including pharmaceutically relevant coformers such as mono- and dihydroxybenzoic acids. The cocrystallization abilities of SMD and EMD with aromatic carboxylic acids were found to be unexpectedly divers despite high formal similarities of these two benzamides and ability of the R2,2(8) heterosynthon formation. The source of diversities of the cocrystallization landscapes is the difference in the stabilization of possible conformers by adopting alternative intramolecular hydrogen boding patterns. The stronger intramolecular hydrogen bonding the weaker affinity toward intermolecular complexation potential. The substituent effects on R2,2(8) heterosynthon properties are also discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Comparison of the methods for discrete approximation of the fractional-order operator

    Directory of Open Access Journals (Sweden)

    Zborovjan Martin

    2003-12-01

    Full Text Available In this paper we will present some alternative types of discretization methods (discrete approximation for the fractional-order (FO differentiator and their application to the FO dynamical system described by the FO differential equation (FDE. With analytical solution and numerical solution by power series expansion (PSE method are compared two effective methods - the Muir expansion of the Tustin operator and continued fraction expansion method (CFE with the Tustin operator and the Al-Alaoui operator. Except detailed mathematical description presented are also simulation results. From the Bode plots of the FO differentiator and FDE and from the solution in the time domain we can see, that the CFE is a more effective method according to the PSE method, but there are some restrictions for the choice of the time step. The Muir expansion is almost unusable.

  1. Byzantine history and the discourse of the Russian political/intellectual underground

    Directory of Open Access Journals (Sweden)

    Dmitry Shlapentokh

    2012-01-01

    In the view of the producer, the Byzantine Empire was strong when it followed its autocratic tradition and was attached to Orthodoxy. The movie generated extensive discussions, including among those who belong to Russia's political and intellectual fringe. Quite a few of them were neo-pagans; for them, Christianity, including Orthodox Christianity, was Russia's curse. For them, it was an Asian creed foreign to Aryan Russians. The fact that it was accepted by Russians implied that Russians had been subjugated by an alien, Asiatic, force. Many of these neo-pagans were quite pessimistic in regard to the country's future; and, indeed, their response indicates the deep alienation of quite a few Russians, which hardly bodes well for the country's future.

  2. Detection of a branched alkyl molecule in the interstellar medium: iso-propyl cyanide.

    Science.gov (United States)

    Belloche, Arnaud; Garrod, Robin T; Müller, Holger S P; Menten, Karl M

    2014-09-26

    The largest noncyclic molecules detected in the interstellar medium (ISM) are organic with a straight-chain carbon backbone. We report an interstellar detection of a branched alkyl molecule, iso-propyl cyanide (i-C3H7CN), with an abundance 0.4 times that of its straight-chain structural isomer. This detection suggests that branched carbon-chain molecules may be generally abundant in the ISM. Our astrochemical model indicates that both isomers are produced within or upon dust grain ice mantles through the addition of molecular radicals, albeit via differing reaction pathways. The production of iso-propyl cyanide appears to require the addition of a functional group to a nonterminal carbon in the chain. Its detection therefore bodes well for the presence in the ISM of amino acids, for which such side-chain structure is a key characteristic. Copyright © 2014, American Association for the Advancement of Science.

  3. Numerical modelling of impedance spectra of ionic conductor-insulator core-shell composites

    Science.gov (United States)

    Laugier, J.-M.; Raymond, L.; Albinet, G.; Knauth, P.

    2011-09-01

    Impedance spectra of ionic conductor-insulator core-shell composites are simulated in Cole-Cole and Bode representation using a 3D lattice of parallel resistance-capacitance elements. The composite model is based on a random ternary network, considering three impedance elements: good conductor (representing interface regions), conductor and insulator. The favourable interactions between the two phases lead to a significant non-random situation versus usual percolation models. Two percolation transitions are well observed: the first corresponds to ionic conduction enhancement by space charge layers. After the second transition, the conduction pathways are blocked by the insulator and the conductivity drops dramatically. Experimental impedance spectra of model copper- and lithium-ion conducting composites and nanocomposites are in good agreement with the simulation. The dc conductivity maximum can be described by a master equation: σmax ~ N-0.79 where N is proportional to the ionic conductor grain size.

  4. Bayesian versus politically motivated reasoning in human perception of climate anomalies

    Science.gov (United States)

    Ripberger, Joseph T.; Jenkins-Smith, Hank C.; Silva, Carol L.; Carlson, Deven E.; Gupta, Kuhika; Carlson, Nina; Dunlap, Riley E.

    2017-11-01

    In complex systems where humans and nature interact to produce joint outcomes, mitigation, adaptation, and resilience require that humans perceive feedback—signals of health and distress—from natural systems. In many instances, humans readily perceive feedback. In others, feedback is more difficult to perceive, so humans rely on experts, heuristics, biases, and/or identify confirming rationalities that may distort perceptions of feedback. This study explores human perception of feedback from natural systems by testing alternate conceptions about how individuals perceive climate anomalies, a form of feedback from the climate system. Results indicate that individuals generally perceive climate anomalies, especially when the anomalies are relatively extreme and persistent. Moreover, this finding is largely robust to political differences that generate predictable but small biases in feedback perception at extreme ends of the partisan spectrum. The subtlety of these biases bodes well for mitigation, adaptation, and resilience as human systems continue to interact with a changing climate system.

  5. What the emerging workforce wants in its leaders.

    Science.gov (United States)

    Wieck, K Lynn; Prydun, Margaret; Walsh, Terri

    2002-01-01

    To describe desired traits as perceived by emerging and entrenched workforce members. A national sample of nursing students (n = 108) and a sample of Midwestern American hospital managers (n = 126) were categorized by age and asked to rank the traits desired in their leaders. Participants ranked the most desired and least desired traits of leaders. Rankings were compared between groups as well as with desired traits from leadership studies in the 1990s. A high degree of congruency was found between emerging and entrenched health care workforce respondents. However, these findings showed little congruence with previous studies. Congruence of expectations facilitates mentoring relationships, so finding no difference between the older and younger groups bodes well for the mentoring of young nurse leaders. The key implication is the challenge to recruit and retain such leaders in the nursing profession in a systematic, logical, and generation-friendly way.

  6. R for fledglings

    Science.gov (United States)

    Donovan, Therese; Brown, Michelle; Katz, Jonathan

    2015-01-01

    We’ve been asked to provide a short introduction to R and its utility in natural resource management. In this short introduction, we can guarantee one thing: you won’t learn R in a few days. That would be like learning to speak French in a few days. To actually learn R, you need to practice….Bode Miller didn’t win his Olympic medals without hours and hours of practice. However, in this short introduction, you can gain an appreciation for what R can do, be introduced to some key functions that you will likely use over and over again, and learn some strategies for creating scripts for automating your work. There are several excellent R books that provide much more information than this short introduction….. R has a steep learning curve, and our hope is to cover some basics to get you over the initial hump.

  7. Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry.

    Science.gov (United States)

    Singh, Ajay K; Ko, Dong-Hyeon; Vishwakarma, Niraj K; Jang, Seungwook; Min, Kyoung-Ik; Kim, Dong-Pyo

    2016-02-26

    Exploration and expansion of the chemistries involving toxic or carcinogenic reagents are severely limited by the health hazards their presence poses. Here, we present a micro-total envelope system (μ-TES) and an automated total process for the generation of the carcinogenic reagent, its purification and its utilization for a desired synthesis that is totally enveloped from being exposed to the carcinogen. A unique microseparator is developed on the basis of SiNWs structure to replace the usual exposure-prone distillation in separating the generated reagent. Chloromethyl methyl ether chemistry is explored as a carcinogenic model in demonstrating the efficiency of the μ-TES that is fully automated so that feeding the ingredients for the generation is all it takes to produce the desired product. Syntheses taking days can be accomplished safely in minutes with excellent yields, which bodes well for elevating the carcinogenic chemistry to new unexplored dimensions.

  8. Universality of electronic friction: Equivalence of von Oppen's nonequilibrium Green's function approach and the Head-Gordon-Tully model at equilibrium

    Science.gov (United States)

    Dou, Wenjie; Subotnik, Joseph E.

    2017-09-01

    For a molecule moving near a single metal surface at equilibrium, following von Oppen and coworkers [N. Bode, S. V. Kusminskiy, R. Egger, and F. von Oppen, Beilstein J. Nanotechnol. 3, 144 (2012), 10.3762/bjnano.3.15] and using a nonequilibrium Green's-function (NEGF) approach, we derive a very general form of electronic friction that includes non-Condon effects. We then demonstrate that the resulting NEGF friction tensor agrees exactly with the Head-Gordon-Tully model, provided that finite temperature effects are incorporated correctly. The present results are in agreement with our recent claim that there is only one universal electronic friction tensor arising from the Born-Oppenheimer approximation [W. Dou, G. Miao, and J. E. Subotnik, Phys. Rev. Lett. 119, 046001 (2017), 10.1103/PhysRevLett.119.046001].

  9. Measurements of control stability characteristics of a wind-tunnel model using a transfer function method

    Science.gov (United States)

    Chopra, I.; Ballard, J. D.

    1980-01-01

    Recent state-of-the-art techniques in rotor systems include the use of active feedback to augment the dynamic control characteristics of an aircraft system. A recent test of a stoppable rotor with blade circulation blowing was conducted in the Ames Research Center's 40by 80-ft wind tunnel. A major part of the test schedule was dedicated to the acquisition of data to determine the stability of a closed-loop hub-moment feedback control system. Therefore, the open-loop control response was measured at several flight conditions to ascertain the stability of the system prior to the final closed-loop feedback control test. Measurements were made during both the stopped and rotating rotor modes, and open-loop Bode plots were obtained for the control loops associated with the moments about the longitudinal and lateral axis.

  10. Control-theoretic Approach to Communication with Feedback: Fundamental Limits and Code Design

    CERN Document Server

    Ardestanizadeh, Ehsan

    2010-01-01

    Feedback communication is studied from a control-theoretic perspective, mapping the communication problem to a control problem in which the control signal is received through the same noisy channel as in the communication problem, and the (nonlinear and time-varying) dynamics of the system determine a subclass of encoders available at the transmitter. The MMSE capacity is defined to be the supremum exponential decay rate of the mean square decoding error. This is upper bounded by the information-theoretic feedback capacity, which is the supremum of the achievable rates. A sufficient condition is provided under which the upper bound holds with equality. For the special class of stationary Gaussian channels, a simple application of Bode's integral formula shows that the feedback capacity, recently characterized by Kim, is equal to the maximum instability that can be tolerated by the controller under a given power constraint. Finally, the control mapping is generalized to the N-sender AWGN multiple access channe...

  11. Hydropower and water supply: competing water uses under a future drier climate modeling scenarios for the Tagus River basin, Portugal

    Science.gov (United States)

    Alexandre Diogo, Paulo; Nunes, João Pedro; Carmona Rodrigues, António; João Cruz, Maria; Grosso, Nuno

    2014-05-01

    Climate change in the Mediterranean region is expected to affect existing water resources, both in quantity and quality, as decreased mean annual precipitation and more frequent extreme precipitation events are likely to occur. Also, energy needs tend to increase, together with growing awareness that fossil fuels emissions are determinately responsible for global temperature rise, enhancing renewable energy use and reinforcing the importance of hydropower. When considered together, these facts represent a relevant threat to multipurpose reservoir operations. Great Lisbon main water supply (for c.a. 3 million people), managed by EPAL, is located in Castelo de Bode Reservoir, in the Tagus River affluent designated as Zêzere River. Castelo de Bode is a multipurpose infrastructure as it is also part of the hydropower network system of EDP, the main power company in Portugal. Facing the risk of potential climate change impacts on water resources availability, and as part of a wider project promoted by EPAL (designated as ADAPTACLIMA), climate change impacts on the Zêzere watershed where evaluated based on climate change scenarios for the XXI century. A sequential modeling approach was used and included downscaling climate data methodologies, hydrological modeling, volume reservoir simulations and water quality modeling. The hydrological model SWAT was used to predict the impacts of the A2 and B2 scenarios in 2010-2100, combined with changes in socio-economic drivers such as land use and water demands. Reservoir storage simulations where performed according to hydrological modeling results, water supply needs and dam operational requirements, such as minimum and maximum operational pool levels and turbine capacity. The Ce-Qual-W2 water quality model was used to assess water quality impacts. According to climate scenarios A2 and B2, rainfall decreases between 10 and 18% are expected by 2100, leading to drier climatic conditions and increased frequency and magnitude of

  12. Cerâmica Pré-Histórica No Litoral Piauiense: Uma Cerâmica Tremembé? / Prehistoric pottery In Coastline Piauiense: A Ceramic Tremembe?

    OpenAIRE

    Santos, Aline Gonçalves dos; Silva, Jacionira Coêlho; Júnior, Julimar Quaresma Mendes

    2013-01-01

    O presente trabalho tem como problemática a identidadedo material cerâmico encontrado em quatro sítios arqueológicoslocalizados no litoral piauiense, Dunas I, Dunas II, Lagoa do Portinhoe Seu Bode, entre os municípios de Parnaíba e Luís Correia. Alémdesses vestígios pré-históricos, existem informações documentaisde que, nos primeiros tempos da colonização, a costa do Piauí eCeará foi habitada por grupos indígenas denominados Tremembé,hoje estudados por etnógrafos nos dois Estados. Relatos de ...

  13. Composition Distribution and Electrochemical Behavior of an Ni2Al3 Coating on Q235 Steel

    Directory of Open Access Journals (Sweden)

    Ningning Li

    2016-03-01

    Full Text Available An Ni2Al3 coating was prepared via the electrodeposition of nickel followed by pack aluminization. Polarization curve and electrochemical impedance spectroscopy were performed to study the room temperature corrosion behavior of the coating in a 3.5 wt. % NaCl solution. The long-term impedance of the coating was also investigated after immersion for 30 days. Results show that the Ni2Al3 coating possessed lower corrosion current density (Icorr and higher polarization resistance (Rp than the substrate in the solution. The Bode plots of the coating showed two time constants after the long-term immersion. Pitting corrosion was found on the coating surface.

  14. Evaluation of “Credit Card” Libraries for Inhibition of HIV-1 gp41 Fusogenic Core Formation

    Science.gov (United States)

    Xu, Yang; Lu, Hong; Kennedy, Jack P.; Yan, Xuxia; McAllister, Laura; Yamamoto, Noboru; Moss, Jason A.; Boldt, Grant E.; Jiang, Shibo; Janda, Kim D.

    2008-01-01

    Protein-protein interactions are of critical importance in biological systems and small molecule modulators of such protein recognition and intervention processes are of particular interests. To investigate this area of research, we have synthesized small molecule libraries that can disrupt a number of biologically relevant protein-protein interactions. These library members are designed upon planar motifs, appended with a variety of chemical functions, which we have termed as “credit-card” structures. From two of our “credit-card” libraries, a series of molecules were uncovered which act as inhibitors against the HIV-1 gp41 fusogenic 6-helix bundle core formation, viral antigen p24 formation and cell-cell fusion at low micromolar concentrations. From the high-throughput screening assays we utilized, a selective index (SI) value of 4.2 was uncovered for compound 2261, which bodes well for future structure activity investigations and the design of more potent gp41 inhibitors. PMID:16827565

  15. Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation.

    Science.gov (United States)

    Xu, Yang; Lu, Hong; Kennedy, Jack P; Yan, Xuxia; McAllister, Laura A; Yamamoto, Noboru; Moss, Jason A; Boldt, Grant E; Jiang, Shibo; Janda, Kim D

    2006-01-01

    Protein-protein interactions are of critical importance in biological systems, and small molecule modulators of such protein recognition and intervention processes are of particular interest. To investigate this area of research, we have synthesized small-molecule libraries that can disrupt a number of biologically relevant protein-protein interactions. These library members are designed upon planar motif, appended with a variety of chemical functions, which we have termed "credit-card" structures. From two of our "credit-card" libraries, a series of molecules were uncovered which act as inhibitors against the HIV-1 gp41 fusogenic 6-helix bundle core formation, viral antigen p24 formation, and cell-cell fusion at low micromolar concentrations. From the high-throughput screening assays we utilized, a selective index (SI) value of 4.2 was uncovered for compound 2261, which bodes well for future structure activity investigations and the design of more potent gp41 inhibitors.

  16. Ice Accretion Modeling using an Eulerian Approach for Droplet Impingement

    Science.gov (United States)

    Kim, Joe Woong; Garza, Dennis P.; Sankar, Lakshmi N.; Kreeger, Richard E.

    2012-01-01

    A three-dimensional Eulerian analysis has been developed for modeling droplet impingement on lifting bodes. The Eulerian model solves the conservation equations of mass and momentum to obtain the droplet flow field properties on the same mesh used in CFD simulations. For complex configurations such as a full rotorcraft, the Eulerian approach is more efficient because the Lagrangian approach would require a significant amount of seeding for accurate estimates of collection efficiency. Simulations are done for various benchmark cases such as NACA0012 airfoil, MS317 airfoil and oscillating SC2110 airfoil to illustrate its use. The present results are compared with results from the Lagrangian approach used in an industry standard analysis called LEWICE.

  17. Brute-force mapmaking with compact interferometers: a MITEoR northern sky map from 128 to 175 MHz

    Science.gov (United States)

    Zheng, H.; Tegmark, M.; Dillon, J. S.; Liu, A.; Neben, A. R.; Tribiano, S. M.; Bradley, R. F.; Buza, V.; Ewall-Wice, A.; Gharibyan, H.; Hickish, J.; Kunz, E.; Losh, J.; Lutomirski, A.; Morgan, E.; Narayanan, S.; Perko, A.; Rosner, D.; Sanchez, N.; Schutz, K.; Valdez, M.; Villasenor, J.; Yang, H.; Zarb Adami, K.; Zelko, I.; Zheng, K.

    2017-03-01

    We present a new method for interferometric imaging that is ideal for the large fields of view and compact arrays common in 21 cm cosmology. We first demonstrate the method with the simulations for two very different low-frequency interferometers, the Murchison Widefield Array and the MIT Epoch of Reionization (MITEoR) experiment. We then apply the method to the MITEoR data set collected in 2013 July to obtain the first northern sky map from 128 to 175 MHz at ∼2° resolution and find an overall spectral index of -2.73 ± 0.11. The success of this imaging method bodes well for upcoming compact redundant low-frequency arrays such as Hydrogen Epoch of Reionization Array. Both the MITEoR interferometric data and the 150 MHz sky map are available at http://space.mit.edu/home/tegmark/omniscope.html.

  18. A Theory of the Origin of the Solar System

    Directory of Open Access Journals (Sweden)

    V. MITRA

    1969-06-01

    Full Text Available theory of tlie origin of the solar system is propounded.
    The approach belongs to the dualistic class of theories but still retains all
    the essential features of a monistic theory. It emphasizes the need of a
    foreign body approaching the solar nebula for the occurrence of an instability
    in the boundary layer of the nebular disc. This foreign body is postulated
    to be a brother star of the Sun in the sense that both belong to a common
    central parent body such as any two successive planets belong to
    the Sun. The analysis gives a law of distance of the planets from tlie Sun.
    This law is obeyed separately by both the groups of the planets more closely
    than the existing Titius - Bode's law. The law is also found to be applicable
    in the various satellite systems.

  19. Control analysis and experimental verification of a practical dc–dc boost converter

    Directory of Open Access Journals (Sweden)

    Saswati Swapna Dash

    2015-12-01

    Full Text Available This paper presents detailed open loop and closed loop analysis on boost dc–dc converter for both voltage mode control and current mode control. Here the boost dc–dc converter is a practical converter considering all possible parasitic elements like ESR and on state voltage drops. The open loop control, closed loop current mode control and voltage mode control are verified. The comparative study of all control techniques is presented. The PI compensator for closed loop current mode control is designed using these classical techniques like root locus technique and bode diagram. The simulation results are validated with the experimental results of voltage mode control for both open loop and closed loop control.

  20. The complex planetary synchronization structure of the solar system

    CERN Document Server

    Scafetta, Nicola

    2014-01-01

    The complex planetary synchronization structure of the solar system, which since Pythagoras of Samos (ca. 570-495 BC) is known as the music of the spheres, is briefly reviewed from the Renaissance up to contemporary research. Copernicus' heliocentric model from 1543 suggested that the planets of our solar system form a kind of mutually ordered and quasi-synchronized system. From 1596 to 1619 Kepler formulated preliminary mathematical relations of approximate commensurabilities among the planets, which were later reformulated in the Titius-Bode rule (1766-1772) that successfully predicted the orbital position of Ceres and Uranus. Following the discovery of the ~11 yr sunspot cycle, in 1859 Wolf suggested that the observed solar variability could be approximately synchronized with the orbital movements of Venus, Earth, Jupiter and Saturn. Modern research have further confirmed that: (1) the planetary orbital periods can be approximately deduced from a simple system of resonant frequencies; (2) the solar system ...

  1. Is love of nature in the US becoming love of electronic media? 16-year downtrend in national park visits explained by watching movies, playing video games, internet use, and oil prices.

    Science.gov (United States)

    Pergams, Oliver R W; Zaradic, Patricia A

    2006-09-01

    After 50 years of steady increase, per capita visits to US national parks have declined since 1988. This decline, coincident with the rise in electronic entertainment media, may represent a shift in recreation choices with broader implications for the value placed on biodiversity conservation and environmentally responsible behavior. We compared the decline in per capita visits with a set of indicators representing alternate recreation choices and constraints. The Spearman correlation analyses found this decline in NPV to be significantly negatively correlated with several electronic entertainment indicators: hours of television, (rs=-0.743, Pgames (rs=-0.773, Pnature (biophilia, Wilson 1984) to 'videophilia,' which we here define as "the new human tendency to focus on sedentary activities involving electronic media." Such a shift would not bode well for the future of biodiversity conservation.

  2. The Surprising History of Claims for Life on the Sun

    Science.gov (United States)

    Crowe, Michael J.

    2011-11-01

    Because astronomers are now convinced that it is impossible for life, especially intelligent life, to exist on the Sun and stars, it might be assumed that astronomers have always held this view. This paper shows that throughout most of the history of astronomy, some intellectuals, including a number of well-known astronomers, have advocated the existence of intelligent life on our Sun and thereby on stars. Among the more prominent figures discussed are Nicolas of Cusa, Giordano Bruno, William Whiston, Johann Bode, Roger Boscovich, William Herschel, Auguste Comte, Carl Gauss, Thomas Dick, John Herschel, and François Arago. One point in preparing this paper is to show differences between the astronomy of the past and that of the present.

  3. Noise Filtering and Prediction in Biological Signaling Networks

    CERN Document Server

    Hathcock, David; Weisenberger, Casey; Ilker, Efe; Hinczewski, Michael

    2016-01-01

    Information transmission in biological signaling circuits has often been described using the metaphor of a noise filter. Cellular systems need accurate, real-time data about their environmental conditions, but the biochemical reaction networks that propagate, amplify, and process signals work with noisy representations of that data. Biology must implement strategies that not only filter the noise, but also predict the current state of the environment based on information delayed due to the finite speed of chemical signaling. The idea of a biochemical noise filter is actually more than just a metaphor: we describe recent work that has made an explicit mathematical connection between signaling fidelity in cellular circuits and the classic theories of optimal noise filtering and prediction that began with Wiener, Kolmogorov, Shannon, and Bode. This theoretical framework provides a versatile tool, allowing us to derive analytical bounds on the maximum mutual information between the environmental signal and the re...

  4. Isotopic investigation of the discharge driven nitrogen dynamics in a mesoscale river catchment

    Science.gov (United States)

    Mueller, Christin; Zink, Matthias; Krieg, Ronald; Rode, Michael; Merz, Ralf; Knöller, Kay

    2016-04-01

    Nitrate in surface and groundwater has increased in the last decades due to landuse change, the application of different fertilizer for agricultural landuse and industrial dust in the atmospheric deposition. Increasing nitrate concentrations have a major impact on eutrophication, especially for coastal ecosystems. Therefore it is important to quantify potential nitrate sources and determine nitrate process dynamics with its drivers. The Bode River catchment (total size of 3200 m2) in the Harz Mountains in Germany was intensively investigated by a monitoring approach with 133 sampling points representing the same number of sub-catchments for a period of two years. The area is characterized by a strong anthropogenic gradient, with forest conservation areas in the mountain region, grassland, and intensively mixed farming in the lowlands. Consecutive discharge simulations by a mesoscale hydrological model (mhM) allow a quantitative analysis of nitrate fluxes for all observed tributaries. The investigation of nitrate isotopic signatures for characteristic landscape types allows the delineation of dominant NO3- sources: coniferous forests are characterized by recycled nitrified soil nitrogen; grassland is mainly impacted by organic fertilizer (manure) and nitrified soil-N; in agricultural land use areas nitrate predominantly derives from synthetic fertilizer application. Besides source delineation, the relationship between runoff and nitrate dynamics was analyzed for the entire Bode river catchment and, more detailed, for one major tributary with minor artificial reservoirs (Selke River). Thereby, it becomes apparent that nitrate isotopic variations increase with decreasing discharge. This effect might be due to a local, more intense impact of bacterial denitrification under low discharge conditions (higher residence time) in the anoxic soil zone, in the groundwater that discharges into the river and in the hyporheic zone. Generally, δ15N and δ18Oof nitrate decrease

  5. TNFA-863 polymorphism is associated with a reduced risk of Chronic Obstructive Pulmonary Disease: A replication study

    Directory of Open Access Journals (Sweden)

    Medina-Coello Chaxiraxi

    2011-10-01

    Full Text Available Background TNF-α mediated inflammation is thought to play a key role in the respiratory and systemic features of Chronic Obstructive Pulmonary Disease. The aim of the present study was to replicate and extend recent findings in Taiwanese and Caucasian populations of associations between COPD susceptibility and variants of the TNFA gene in a Spanish cohort. Methods The 3 reported SNPs were complemented with nine tag single nucleotide polymorphisms (SNP of the TNFA and LTA genes and genotyped in 724 individuals (202 COPD patients, 90 smokers without COPD and 432 healthy controls. Pulmonary function parameters and serum inflammatory markers were also measured in COPD patients. Results The TNFA rs1800630 (-863C/A SNP was associated with a lower COPD susceptibility (ORadj = 0.50, 95% CI = 0.33-0.77, p = 0.001. The -863A allele was also associated with less severe forms of the disease (GOLD stages I and II (ORadj = 0.303, 95%CI = 0.14-0.65, p = 0.014 and with lower scores of the BODE index (1 percent predicted (p = 0.004 and a lower BODE index (p = 0.003 over a 2 yrs follow-up period. None of the TNFA or LTA gene variants correlated with the serum inflammatory markers in COPD patients (p > 0.05. Conclusions We replicated the previously reported association between the TNFA -863 SNP and COPD. TNFA -863A allele may confer a protective effect to the susceptibility to the disease in the Spanish population.

  6. COPD assessment test (CAT): simple tool for evaluating quality of life of chemical warfare patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Lari, Shahrzad M; Ghobadi, Hassan; Attaran, Davood; Mahmoodpour, Afsoun; Shadkam, Omid; Rostami, Maryam

    2014-01-01

    Chronic obstructive pulmonary disease (COPD) is one of the serious late pulmonary complications caused by sulphur mustard exposure. Health status evaluations of chemical warfare patients with COPD are important to the management of these patients. The aim of this study was to determine the efficacy of the COPD assessment test (CAT) in evaluating the health-related quality of life (HRQOL) of chemical warfare patients with COPD. Eighty-two consecutive patients with stable COPD were enrolled in this study. All subjects were visited by one physician, and the HRQOL was evaluated by the CAT and St. George Respiratory Questionnaires (SGRQs). In addition, a standard spirometry test, 6-min walk distance test and pulse oxymetry were conducted. The severity of the COPD was determined using Global Initiative for Chronic Obstructive Lung Disease (GOLD) staging and the body mass index, obstruction, dyspnoea and exercise (BODE) index. The mean age of the patients was 47.30 ± 7.08 years. The mean CAT score was 26.03 ± 8.28. Thirty-five (43%) patients were in CAT stage 3. There were statistically significant correlations between the CAT and the SGRQ (r = 0.70, P = 0.001) and the BODE index (r = 0.70, P = 0.001). A statistically significant inverse correlation was found between the CAT score and the forced expiratory volume in 1 s (r = -0.30, P = 0.03). Our results demonstrated that the CAT is a simple and valid tool for assessment of HRQOL in chemical warfare patients with COPD and can be used in clinical practice. © 2013 John Wiley & Sons Ltd.

  7. Functional outcomes after lung transplant in chronic obstructive pulmonary disease.

    Science.gov (United States)

    Cerón Navarro, José; de Aguiar Quevedo, Karol; Ansótegui Barrera, Emilio; Jordá Aragón, Carlos; Peñalver Cuesta, Juan Carlos; Mancheño Franch, Nuria; Vera Sempere, Francisco José; Padilla Alarcón, Jose

    2015-03-01

    Lung transplantation (LT) is a therapeutic option with controversial results in chronic obstructive pulmonary disease (COPD). We aimed to analyze the outcomes of transplantation in terms of lung function and to identify prognostic factors. A retrospective analysis of 107 patients with COPD receiving lung transplants in the La Fe Hospital between 1991 and 2008 was performed. Preoperative variables, pulmonary function tests before and after LT, surgical procedure variables and long-term monitoring, expressed as mean or percentage, as applicable, were analyzed. Spirometric results before and after LT were analyzed. Linear or logistic regression were used for multivariate analysis depending on the variable. Ninety-four men (87.9%) and 13 women (12.1%) were transplanted, with a mean age±standard deviation of 52.58±8.05 years; 71% of LTs were double-lung transplantations. Spirometric values improved after LT: FVC: +1.22L (+34.9%), FEV1: +1.66L (+56.7%) and FEF25-75: +1.85L (+50.8%); P=.001. This functional improvement was maintained after 5 years only in the group with BODE score >7 (P=.001). Recipient height, type of LT, use of extracorporeal circulation during the surgical procedure, presence of bronchiolitis obliterans syndrome and the age and cause of death of the donor significantly influenced lung function over time. LT improves lung function in COPD patients. This improvement was maintained at 5years only in patients with BODE>7. Double lung transplantation provides better functional results than single-lung transplantation. Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.

  8. Clinical utility of computed tomographic lung volumes in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Lee, Jae Seung; Lee, Sang-Min; Seo, Joon Beom; Lee, Sei Won; Huh, Jin Won; Oh, Yeon-Mok; Lee, Sang-Do

    2014-01-01

    Published data concerning the utility of computed tomography (CT)-based lung volumes are limited to correlation with lung function. The aim of this study was to evaluate the clinical utility of the CT expiratory-to-inspiratory lung volume ratio (CT Vratio) by assessing the relationship with clinically relevant outcomes. A total of 75 stable chronic obstructive pulmonary disease (COPD) patients having pulmonary function testing and volumetric CT at full inspiration and expiration were retrospectively evaluated. Inspiratory and expiratory CT lung volumes were measured using in-house software. Correlation of the CT Vratio with patient-centered outcomes, including the modified Medical Research Council (MMRC) dyspnea score, the 6-min walk distance (6MWD), the St. George's Respiratory Questionnaire (SGRQ) score, and multidimensional COPD severity indices, such as the BMI, airflow obstruction, dyspnea, and exercise capacity index (BODE) and age, dyspnea, and airflow obstruction (ADO), were analyzed. The CT Vratio correlated significantly with BMI (r = -0.528, p < 0.001). The CT Vratio was also significantly associated with MMRC dyspnea (r = 0.387, p = 0.001), 6MWD (r = -0.459, p < 0.001), and SGRQ (r = 0.369, p = 0.001) scores. Finally, the CT Vratio had significant correlations with the BODE and ADO multidimensional COPD severity indices (r = 0.605, p < 0.001; r = 0.411, p < 0.001). The CT Vratio had significant correlations with patient-centered outcomes and multidimensional COPD severity indices. © 2013 S. Karger AG, Basel.

  9. Birmingham COPD Cohort: a cross-sectional analysis of the factors associated with the likelihood of being in paid employment among people with COPD

    Science.gov (United States)

    Rai, Kiran K; Jordan, Rachel E; Siebert, W Stanley; Sadhra, Steven S; Fitzmaurice, David A; Sitch, Alice J; Ayres, Jon G; Adab, Peymané

    2017-01-01

    Background Employment rates among those with chronic obstructive pulmonary disease (COPD) are lower than those without COPD, but little is known about the factors that affect COPD patients’ ability to work. Methods Multivariable analysis of the Birmingham COPD Cohort Study baseline data was used to assess the associations between lifestyle, clinical, and occupational characteristics and likelihood of being in paid employment among working-age COPD patients. Results In total, 608 of 1,889 COPD participants were of working age, of whom 248 (40.8%) were in work. Older age (60–64 years vs 30–49 years: odds ratio [OR] =0.28; 95% confidence interval [CI] =0.12–0.65), lower educational level (no formal qualification vs degree/higher level: OR =0.43; 95% CI =0.19–0.97), poorer prognostic score (highest vs lowest quartile of modified body mass index, airflow obstruction, dyspnea, and exercise (BODE) score: OR =0.10; 95% CI =0.03–0.33), and history of high occupational exposure to vapors, gases, dusts, or fumes (VGDF; high VGDF vs no VGDF exposure: OR =0.32; 95% CI =0.12–0.85) were associated with a lower probability of being employed. Only the degree of breathlessness of BODE was significantly associated with employment. Conclusion This is the first study to comprehensively assess the characteristics associated with employment in a community sample of people with COPD. Future interventions should focus on managing breathlessness and reducing occupational exposures to VGDF to improve the work capability among those with COPD. PMID:28138233

  10. Distribution and Outcomes of a Phenotype-Based Approach to Guide COPD Management: Results from the CHAIN Cohort.

    Directory of Open Access Journals (Sweden)

    Borja G Cosio

    Full Text Available The Spanish guideline for COPD (GesEPOC recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE, asthma-COPD overlap syndrome (ACOS, frequent exacerbator phenotype with emphysema (FEE or frequent exacerbator phenotype with chronic bronchitis (FECB. However, little is known on the distribution and outcomes of the four suggested phenotypes.We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes.We followed a cohort of well-characterized patients with COPD up to one-year. Baseline characteristics, health status (CAT, BODE index, rate of exacerbations and mortality up to one year of follow-up were compared between the four phenotypes.Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550 (66.2%; ACOS, 125 (15.0%; FEE, 38 (4.6%; and FECB, 99 (11.9%; additionally 19 (2.3% COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE nor FECB. At baseline, there were significant differences in symptoms, FEV1 and BODE index (all p<0.05. The FECB phenotype had the highest CAT score (17.1±8.2, p<0.05 compared to the other phenotypes. Frequent exacerbator groups (FEE and FECB were receiving more pharmacological treatment at baseline, and also experienced more exacerbations the year after (all p<0.05 with no differences in one-year mortality. Most of NE (93% and half of exacerbators were stable after one year.There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant differences in demographics, patient-centered outcomes and health care resources use.

  11. Diseño de Herramientas Didácticas Enfocadas al Aprendizaje de Sistemas de Control Utilizando Instrumentación Virtual

    Directory of Open Access Journals (Sweden)

    J. Martínez

    2017-10-01

    Full Text Available Resumen: En este artículo se describe el diseño de tres herramientas didácticas enfocadas al aprendizaje de sistemas de control implementadas en el software de instrumentación virtual LabVIEW. Estas herramientas están dirigidas al análisis de estabilidad en sistemas de control, el diseño de compensadores utilizando la técnica del lugar geométrico de las raíces y el diseño de compensadores utilizando la técnica de respuesta en frecuencia con trazas de Bode. Cada una de estas herramientas didácticas cuenta con una interfaz gráfica amigable con el usuario. La ventaja de estas herramientas didácticas es que incluyen opciones para realizar simulación en las áreas de control que software especializado no tiene. Abstract: This paper describes the design of three didactic tools focused on learning of control systems implemented in LabVIEW virtual instruments software. These tools are dedicated to stability analysis in control systems, compensator design using root locus approach and Bode diagrams in the frequency domain. Each of them has a friendly interface with the user. The advantage of these didactic tools is the several options to simulate some characteristics referent to control in contrast with others teaching tools. Palabras clave: Estabilidad, Simulación de Sistemas, Educación en Control, Laboratorio Virtual, Keywords: Stability, simulation systems, control education, virtual laboratory

  12. PREFACE: EDS2010 Preface

    Science.gov (United States)

    Heggie, Malcolm I.

    2011-03-01

    The biennial international conference on Extended Defects in Semiconductors started in 1978 with a meeting in Hünfeld, Germany. Subsequent meetings rotated between Poland, France, Great Britain, Germany, Russia and Italy, culminating in EDS2004 in Chernogolovka, EDS2006 in Halle and EDS2008 in Poitiers. EDS2010 was held at the University of Sussex at Brighton, UK from September 19th to 24th. An extension of the tabulation of this history, which first appeared on the EDS2006 website, is given in the attached PDF. It is with sadness that we note one of the founders of the series, Prof. Dr Helmut Alexander, passed away on 3 December 2009 and we were proud to dedicate EDS2010 to his memory. It has become a tradition to make an award in his name, and this year it was made to Ivan Isacov for his poster "Electrical levels of dislocation networks in p- and n-type silicon". A short and warm celebration of Prof. Dr Alexander's life by his friends and colleagues, Prof. Drs Helmut Gottschalk, Eicke Weber and Wolfgang Schröter, is included in this volume. The conference was a forum for the state-of-the-art of investigation and modelling of extended defects in semiconductors. Scientists from universities, research institutes and industry made contributions to a deeper understanding of extended defects, their interaction with point defects and their role in the development of semiconductor technology. The remit of the conference included extended defects, nanostructures, nanoparticles, quantum dots and interfaces within semiconducting materials ranging from narrow to wide band gaps, including graphene-derived materials and diamond. Scientific interests range from defect geometry, electronic structure, dynamics, spectroscopy, microscopy, reactions and chemistry to introduction mechanisms, such as implantation and strained layers and the operation of devices such as integrated circuits, heterostructures, and solar cells. The organisers were confronted with a long period between

  13. Anatomy during the Third Reich--the Institute of Anatomy at the University of Marburg, as an example.

    Science.gov (United States)

    Aumüller, G; Grundmann, K

    2002-05-01

    A complete documentation of German anatomical science and its representatives during the period of national socialism has not been published as yet--contrary to the situation in other medical disciplines. Instead of German anatomists, American anatomists have occasionally addressed this issue during their meetings and have reported on special aspects, such as the use of Nazi symbols in anatomical textbooks and atlases (Pernkopf 1952) and the use of corpses of justice victims for anatomical research and student education. Also, the genesis of the atrocious collection of "racial" skulls, initiated along with the SS-institution of the "Ahnenerbe" by the anatomist August Hirt of Strasbourg (who ordered more than 90 inmates from concentration camps to be murdered in the gas chamber built in the concentration camp of Natzweiler-Struthof close to Strasbourg, Alsace) has been described by Frederic Kasten and others. A broader view of the patterns of behaviour and political actions and fates of contemporary scientists, ranging from dismissal to clandestine opportunism, affirmative cooperation and fanatic activism can be obtained by the analysis of the activities in research, medical education and academic positions of the following members of the Institute of Anatomy at the Philipp-University in Marburg: Ernst Göppert, Eduard Jacobshagen, Ernst-Theodor Nauck, Adolf Dabelow, Helmut Becher and Alfred Benninghoff, whose activities and fates differ in several respects and allow more general deductions. Also, the individual fates of a number of prosecuted Jewish anatomists (Wassermann, München; Poll, Hamburg), of devoted and active members of the Nazi party (Clara, Leipzig; Blotevogel, Breslau) and of criminal fanatics (Hirt, Strasbourg; Kremer, Münster) are briefly discussed. The present contribution is an attempt to initiate a more detailed study of all German departments of anatomy during the Hitler regime and to generate a public discussion among the younger generation of

  14. Рекомендации по электрокардиостимуляции и сердечной ресинхронизирующей терапии

    OpenAIRE

    2008-01-01

    Специальная комиссия по электрокардиостимуляции и сердечной ресинхронизирующей терапии Европейского общества кардиологии. Разработано в сотрудничестве с Европейской ассоциацией ритма сердца Авторы/члены специальной комиссии: Panos E. Vardas* (председатель) (Греция); Angelo Auricchio (Швейцария); Jean-Jacques Blanc (Франция); Jean-Claude Daubert (Франция); Helmut Drexler (Германия); Hugo Ector (Бельгия); Maurizio Gasparini (Италия); Cecilia Linde (Швеция); Francisco Bello Morgado (Португалия);...

  15. Development of pediatric cardiology in latin america: accomplishments and remaining challenges.

    Science.gov (United States)

    Capelli, Horacio; Kreutzer, Christian; Kreutzer, Guillermo

    2011-01-01

    Until the first quarter of the 20th century, most physicians were more than happy to differentiate congenital heart lesions from rheumatic heart disease, which then was rampant. As early as 1932, Dr Rodolfo Kreutzer, from Buenos Aires, Argentina, was already involved in the study of congenital heart defects. He started off assessing children with a stethoscope and with Einthoven electrocardiography equipment. The cardiac unit at the Buenos Aires Children's Hospital was created in 1936. It established the onset of pediatric cardiology in Argentina and fueled its development in South America. Nearly at the same time, Agustin Castellanos from Cuba also became a pioneer in the assessment of congenital heart disease. He described the clinical applications of intravenous angiocardiography in 1937. Meanwhile in Mexico, Dr Ignacio Chavez founded the National Institute of Cardiology in 1944 in Mexico City. It was the first center in the world to be exclusively devoted to cardiology. From this center, Victor Rubio and Hugo Limon performed the first therapeutic cardiac catheterization in 1953. Meanwhile, Professor Euriclydes Zerbini from Sao Paulo, Brazil, built the largest and most important school of cardiac surgeons in South America. In Santiago, Chile, the Calvo Makenna Hospital was the center where Helmut Jaegger operated on the first infant with extracorporeal circulation in Latin America in 1956. The patient was a 1-month-old baby, with complete transposition of the great arteries, who underwent an Albert procedure. Currently, there are many fully equipped centers all over the region, capable of dealing with most lesions and of providing excellent medical, interventional, and surgical treatment. Outcomes have improved substantially over the last 20 years. These achievements have gone beyond our pioneers' dreams. However, many neonates and young infants die prior to surgery because referral centers are overburdened and have long surgical waiting lists. Clearly, we still

  16. Biomass, biogas, biofuels.... Questions and answers; Biomasse, Biogas, Biotreibstoffe... Fragen und Antworten

    Energy Technology Data Exchange (ETDEWEB)

    Faulstich, M.; Prechtl, S. (eds.)

    2007-07-01

    Within the scope of the 3rd symposium ''Processes and materials for energy technologies'', held between 20th and 21st June, 2007, at the ATZ Entwicklungszentrum in Sulzbach-Rosenberg (Federal Republic of Germany), the following lectures were held: (a) What is the future of the bioenergy? (Stephan Prechtl, Sulzbach-Rosenberg); (b) What are the legal news in the range of biogas and biomass? (Michael Roessert, Augsburg); (c) How will the European market of manufacturing plants develop? (Anton Mederle); (d) Availability of raw materials for the production of biofuels in the Germany and in the EC 25 (Juergen Zeddies, Dietrich Klein); (e) Domestic species of plants and their suitability as a supplier of energy and raw materials (Helmar Prestele); (f) What can the biomass perform in Germany? (Martin Faulstich, Kathrin Greiff); (g) When is the combustion of fermentation remainders significant? (Dieter Korz); (h) Attempt of an answer on the question: What burns better, grain or straw? (Fritz Grimm); (i) How does the use of biomass in high-temperature processes look like? (Helmut Seifert, Thomas Kolb, Andreas Hornung); (j) How can biomass be used best? (Udo Dinglreiter); (k) Which chances are offered by contracting models in the biogas sector? (Wilhelm Hiller, Diana Baumgaertner); (l) How can biogas be generated in compost heap? (Ottomar Ruehl, Rainer Scholz); (m) How does an investor of biofuel projects decide? (Klaus Hildebrand); (n) How fast can I drive with autogas, biogas or natural gas? (Peter Biedenkopf); (o) Use of vegetable oil in diesel engines (Markus Brautsch); (p) What are the targets of the bavarian energy policy? (Gerd von Laffert).

  17. The Effect of Ultraviolet Light on the "Liquid Wood"

    Science.gov (United States)

    Dumitru, Nedelcu; Sabina, Zǎgan; Ticuta, Negreanu-Pirjol; Remus, Zǎgan; Constantin, Cǎrausu

    2014-08-01

    To preserve resources, the goal is to use biobased materials containing the maximum possible amount of renewable biomass-based derivatives to secure a sustainable future. Bioplastics, biocomposites, biological fibres and related biomaterials will serve as substitutes for materials and products traditionally made from petroleum resources. To support this need, in 1998, Fraunhofer Institute of Chemistry and Tecnaro GmbH Company (founded by Jurgen Pfitzer and Helmut Nagele in Germany) investigated and developed a new compound made of wood components that can be processed as a thermoplastic material. It is well known that bioplastic and biocomposite materials represent another important group of bio-materials that include plastics reinforced with natural fibers and wood-plastic composites (WPCs). The aim of this research is to identify the behavior of "Liquid Wood" after UV irradiation. The materials used were Arbofill Fichte, Arboblend V2 Nature and Arboform L, V3 Nature. The samples were obtained by injection and the experimental study plan followed the Taguchi method with six input parameters and two levels for each of them. Three samples from each material were tested in an ultraviolet environment using different time of exposure in order to establish the material characteristics. After the irradiation process the material did not turn to yellow, which suggests that the composition of the sample liquid timber inhibitors have stability and the number of α-carbonyl (C = O) groups is sufficiently low. After the graphs analyzing can be inferred relatively similar performance of the samples in the first stage both UV and the VIS, indicating that the activity is almost absent. In UV is clearly observed the peak amplitude (maximum absorbance) at different wavelengths (λ). So, in terms of peak intensity the samples follow the order: Arboform L, V3 Nature; Arbofill Fichte and Arboblend V2 Nature.

  18. A preliminary report of the dopamine receptor D4 and the dopamine transporter 1 gene polymorphism and its association with attention deficit hyperactivity disorder

    Directory of Open Access Journals (Sweden)

    Helmut Niederhofer

    2008-09-01

    Full Text Available Helmut Niederhofer1, Frauke Menzel2, Karl Göbel3, Brigitte Hackenberg4,5, Rainer Richter2,6, Maria Hildegard Walter2, Christian Gross7, Markus Huber8, Roger Pycha8, Hans-Jürgen Menzel9,101Ospedale Regionale di Bolzano, Via Guncina, Bolzano, Italia; 2Institute for Psychology, University of Innsbruck, Innsbruck, Austria; 3Freiburger Allee 67, Böblingen, Germany; 4University Clinic for Psychiatry, 9Institute for Medical Biology and Human Genetics, Medical University of Innsbruck, Innsbruck, Austria; 5University Clinic for Pediatrics, Medical University Vienna, Wien, Austria; 6Department of Psychosomatic Medice and Psychotherapy, University Hospital, Eppendorf, Hamburg, Germany; 7Institut für Heilpädagogik, Klessheimer Allee 81, Salzburg, Austria; 8Krankenhaus Bruneck, Bruneck, ItaliaAbstract: Attention deficit hyperactivity disorder (ADHD is one of the most prevalent childhood-onset psychiatric syndromes affecting 5%–10% of school-age children worldwide. Distortions in the catecholaminergic system seem to be responsible for this condition. Within this system there are several candidate genes, the dopamine receptor D4 (DRD4 and the dopamine transporter 1 (DAT1, with common polymorphism which might be associated with ADHD. We performed a family based association study with 36 trios and 19 parent proband pairs. All diagnoses were confirmed by the “Hypescheme” diagnostic computer program. In this study we did not observe an association of ADHD with DRD4 and DAT1 polymorphism neither by the haplotype relative risk (HRR method nor by the transmission disequilibrium test (TdT method. The odds ratio for the DRD4 7-allele was 1.01 and 0.94 for both statistical tests, respectively, and the respective odds ratio for the DAT1 6-allele were 0.91 and 0.88.Keywords: ADHD, dopamine receptor D4, dopamine transporter, haplotype relative risk, transmission disequilibrium test

  19. Energetic use of renewable fuels. Logistics of energy carrier supply, technologies of usage, boundary conditions for economically efficient use of biomass. Proceedings; Energetische Nutzung nachwachsender Rohstoffe. Logistik der Energietraegerbereitstellung, Technologien der Energietraegernutzung, Rahmenbedinungen fuer den wirtschaftlichen Einsatz von Biomasse. Vortraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Within the workshop of the Fraunhofer Institute for Manufacturing Engineering and Automation IPA (Stuttgart, Federal Republic of Germany) at 6th October, 2009, in Stuttgart the following lectures were held: (1) State of the art and perspectives of the utilization of renewable raw materials in Germany (Helmut Lamp); (2) The Act on Power Generation from Renewable Energy Sources (EEWaermeG) and the German Energy Saving Ordinance (ENEV) (Martin Maslaton); (3) Biomass: Procurement and logistics in Europe (Hubert Roeder); (4) Obstacles with the mobilization of wood from the private forest (Frank Setzer); (5) Environmental effects of the production of field wood - Evaluation of long-term investigations (Volkhard Scholz, Juergen Kern, Antje Balasus); (6) Potentials of biomass and renewable raw materials in Hungary (Istvan Hagen, Andrea Hangosi, Zsolt Tegla); (7) Regional energy concepts for the extension of biomass utilization using the bio energy region ''Saxonian Switzerland - Eastern Erzgebirge'' as an example'' (Burkhard Zschau); (8) Biomass - wooden ash circular process at Baden Wuerttemberg as an example (Klaus von Wilpert); (9) Launching of a bio ampere technology of wood gasification (Dietmar Bendix, Rolf Noppen); (10) Wood gas power plant Senden - transformation - optimization - technology (Matthias Vitek); (11) A general view of heating installations with wood fuels with a performance of up to 70 kW and additional components for the energetic and emission technical optimization (Wilfried Linke); (12) Financial incentives for the innovative reduction of dust emissions for biomass furnaces according to the 1st German Federal Immission Control Act (Andrej Stanev); (13) Alternative fuels in heat generation plants up to 1 MW (Thomas Hening); (14) Industrial-scale pellet systems in Germany (Stefan Weiner); (15) Supercritical reformation of energy sources to syngas (Yevgeny Makhynya, Stefan Peil, Dieter Bathen); (16) The GoBiGas (Gothenburg

  20. The Metaphor of the Jewish People in the English Poetry by Rose Ausländer on the Example of the Poems “The Forbidden Tree” and “The Clinic”

    Directory of Open Access Journals (Sweden)

    Iryna Vikyrchak

    2017-12-01

    Full Text Available The article examines the image of the Jewish people in English poetry by Rosa Ausländer. Born in 1901 in Austrian Chernivtsi, a German-speaking poet changes the language of her writing after survuvung through the Holocaust and for almost ten years writes in English during the emigration in New York. The main motives of this period are the search for a new identity, the experience of having lost her mother and rethinking the horrors of the Second World War and its consequences for the Jewish people and for Europe in general English poetry written by Rosa Ausländer between 1947 and 1956 was published by Helmut Braun in 1995 in a collection tittles “The Forbidden Tree”. The program poem under the same title depicts a tree from the Garden of Eden maimed by the Nazis, the roots of which, in spite of everything, are strong and “vigorous”. In the poem “The Clinic” the surface motive is the rapid pace of life in the megalopolis, which also belongs to the leading motives of this period of writing and the life of the poetess. However, the images of “impersonal names”, a sense of distrust to state institutions, long waiting for the unknown and a reference to the typical image of the phoenix often used by Ausländer give the reader implicit indications of the Shoah's traumatic experience. In the poetry of Rosa Ausländer, the phoenix remains a symbol of hope and rebirth for the Jewish people.

  1. Identificación de parámetros con métodos numéricos para el modelado de sistemas eléctricos con dependencia frecuencial;Identification of parameters with numerical methods for the modelling of electrical systems with frequency dependence.

    Directory of Open Access Journals (Sweden)

    Eduardo Salvador Bañuelos Cabral

    2015-06-01

    Full Text Available El artículo presenta una descripción detallada de las técnicas más utilizadas para hacer ajuste racional de funciones del dominio de la frecuencia. Las técnicas son: Aproximación Asintótica de Bode, Mínimos Cuadrados Ordinarios, Mínimos Cuadrados Iterativamente Reponderados, Ajuste Vectorial y Levenberg-Marquardt. Estas técnicas se comparan aproximando una función analítica. Después, se aplican al ajuste racional de parámetros dependientes de la frecuencia de una línea de transmisión monofásica. El efecto del ajuste se evalúa considerando los casos de línea abierta, corto circuito y perfectamente acoplada. La transformada numérica de Laplace (NLT se utiliza como referencia para la evaluación. Se concluye que la adecuada implementación de cada técnica depende de varios factores; del tipo de función a ajustar, del rango de ajuste, y otros. Además, no es posible garantizar que una de las técnicas siempre converja al mejor resultado. El artículo propone algunas guías para seleccionar la técnica más adecuada para una aplicación particular. This paper provides a detailed description of the rational fitting techniques that are most used to approximate frequency domain functions. The techniques are: Bode asymptotic approximations, Ordinary Least-Squares, Iteratively Reweighted Least-Squares, Vector Fitting and Levenberg-Marquardt. These techniques are compared by approximating of an analytic function. Then, the techniques are applied to the rational-fitting of the frequency-dependent parameters corresponding to a single-phase transmission line. The effect of the rational representations is evaluated considering transients on cases of open-ended, short-circuited and perfectly matched lines. The numerical Laplace transform technique (NLT is used as reference for the evaluations. It follows that the proper implementation of each fitting technique depends on various factors; the type of function being adjusted, the desired

  2. [The clinical characteristics of intra-acinar pulmonary artery inflammation and its effect on clinical parameters in smokers with normal lung function and patients with chronic obstructive pulmonary disease].

    Science.gov (United States)

    Lao, Qi-fang; Zhong, Xiao-ning; He, Zhi-yi; Liu, Guang-nan; Lü, Zi-li; Wan, Peng

    2011-10-01

    To study the pathological characteristics of intra-acinar pulmonary artery inflammation and its correlation with smoking index and disease progression in smokers with normal lung function and smokers with chronic obstructive pulmonary disease (COPD). Patients requiring lung resection for peripheral lung cancer were divided into group A (nonsmokers with normal lung function, n = 10), group B (smokers with normal lung function, n = 13), and group C (smokers with stable COPD, n = 10). The lung tissue far away from tumor were resected to compare the pathological changes of intra-acinar pulmonary arteries and infiltration level of inflammatory cell in pulmonary non-muscularized arteries (NMA), pulmonary partially muscularized arteries (PMA) and muscularized arteries (MA) among the three groups. The correlation analysis was made among infiltration level, smoking index, percentage of predicted value of forced expiratory volume in one second (FEV(1)%Pred), six-minute-walk distance (6MWD) and BODE index. (1) Both group B and group C showed the intima and media thickness of MA was significantly higher, the lumen area of MA was narrower and the proportion of MA was higher, and collagenous fiber of MA adventitial proliferated and area increased in group C (P arteries that contained leukocytes, T lymphocytes, CD(8)(+)T lymphocytes and the number of these positive cells infiltrating the intra-acinar pulmonary arteries were increased, especially an increased number of CD(8)(+)T lymphocytes infiltrating in the arterial adventitia as compared with group A, moreover there were significant difference between group C and group B (P 0.05). (3) The number of leukocytes, T lymphocytes, CD(8)(+)T lymphocytes infiltrating MA showed a positive correlation with the thickness of MA (r = 0.563, 0.627, 0.589, P arterial inflammation appears in smokers with normal lung function and smokers with COPD patients. It involves in all types of intra-acinar pulmonary arteries especially NMA and

  3. Fatores genéticos e de ambiente sobre o intervalo de partos de cabras leiteiras no semi-árido nordestino Genetic and environmental factors affecting the kidding interval of dairy goats in the semi-arid Northeastern

    Directory of Open Access Journals (Sweden)

    José Lindenberg Rocha Sarmento

    2003-08-01

    Full Text Available Objetivou-se estudar a influência de efeitos genéticos e ambientais sobre o intervalo de partos, utilizando-se 486 registros de parição de cabras leiteiras mestiças criadas entre 1988 e 1996, no Estado da Paraíba. Os efeitos ambientais foram analisados pelo procedimento GLM do SAS por meio de um modelo que incluiu os efeitos fixos de grupo contemporâneo e tipo de parto, as covariáveis idade da cabra ao parto e duração da lactação e os efeitos aleatórios de bode e cabra dentro de bode e erro. O programa MTDFREML foi usado para estimar os parâmetros genéticos sob modelo animal, que incluía os mesmos efeitos fixos e covariáveis do modelo anterior. Como aleatórios foram considerados os efeitos genético aditivo, permanente de meio e erro. O intervalo de parto médio obtido foi 275,55 ± 60,96 dias. Os efeitos de grupo contemporâneo e duração da lactação influenciaram o intervalo de partos. As estimativas de herdabilidade e repetibilidade foram de baixa magnitude, 0,09 e 0,09, respectivamente, indicando que reduções mais rápidas nessa característica seriam obtidas por meio de melhorias no manejo.The aims of this study were evaluate influence of the environmental and genetic effects on the kidding interval, using 486 records of kidding crossbred dairy goats obtained from 1988 to 1996 in Paraiba State. The environmental effects were analyzed by means of the procedure GLM of the SAS with a model that included as fixed factors the contemporary group and kidding type, and covariates age of goat at kidding and lactation length. Buck, goat inside of the buck and error were included as random effects. MTDFREML program was used in the analysis with an animal model containing the contemporary group and kidding type, the linear and quadratic effects of age of kidding and lactation length as fixed effects. Animal and permanent environmental and error were included as random effects. The least-square means of kidding interval was 275

  4. Investigation of Large Scale Hydrological and Hydrochemical Processes by Regional Isotope Patterns

    Science.gov (United States)

    Knoeller, K.; Mueller, C.; Krieg, R.; Merz, R.

    2012-12-01

    Isotope studies conducted over large spatial and/or temporal scales can provide powerful insights into natural ecosystem processes and the effects of anthropogenic influences. The challenge of the presented project is to characterize and quantify large (regional) scale dynamics and trends in water and solute fluxes from two European catchments representing changing environmental conditions (e.g. elevated inputs, land use and climate change). One investigated area, the test site of the Bode region in the Harz Mountains, Germany, with an area of 3,200 km2, is part of the TERENO (Terrestrial Environmental Observatory) project. The second catchment is the Erlauf hydrographic basin in the alpine foothills in Austria covering an area of ca. 600 km2. The development of a statistically refined monitoring-network integrating a multi-isotopic approach is one primary objective of the conducted study. 133 stream water samples were taken in the Bode catchment in Germany for each of the three different sampling campaigns in 2012. All sampling locations represent the discharge from 133 sub-catchments. Consequently, hydrochemical data and isotopic signatures of the water samples were subsequently assigned to the respective sub-catchments. The smaller Erlauf catchment in Austria was characterized by 41 water samples for each sampling campaign considered to be representative for 41 sub-catchments. Laboratory analyses on all water samples were conducted for stable isotope signatures of water (δ18O, δ2H), of sulfate (δ34S and δ18O), of dissolved inorganic and organic carbon (δ13CDIC) and of nitrate (δ15N and δ18O). Regional isotope patterns of the different isotope systems obtained during the monitoring campaigns are combined with available regional data (e.g. elevation, elevation gradient, slope, vegetation cover, land use, soil, geology etc.). The temporal and spatial isotope distribution patterns and their combination with regional data undergo a comprehensive geo

  5. Estudio mediante EIS de la respuesta electroquímica de la aleación AA5083 frente a señales DC anódicas

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    Aballe, A.

    1998-05-01

    Full Text Available Electrochemical Impedance Spectroscopy (EIS has been applied to characterise the behaviour of AA5083 alloy samples under anodic polarisation in a 3.5 % NaCl solution. EIS spectra were obtained at different DC potentials falling within the passivity range characteristic of the anodic polarisation branch of this alloy in the cited corrosive environment. Three different types of electrochemical response, with specific features in the corresponding Nyquist diagrams, were observed within the potential range covered in this study. The different type of spectra have been fitted with equivalent circuits. The evolution of the values of the different elements in the circuits as a function of the applied DC polarisation potential has been established. The analysis of these data has allowed us to determine the ranges of polarisation potentials where the passivation layer remains stable, metastable pits are nucleated or where stable pits grow. Finally, the use of a "Bode Surface Plot" has been proposed to get a better visualization of the evolution of the system with the applied DC potential.

    Se ha llevado a cabo un estudio, mediante Espectroscopia de Impedancia Electroquímica (EIS, del comportamiento de la aleación AA5083 polarizada anódicamente en disolución de NaCl al 3,5 %. Los espectros de impedancia se registraron a distintos potenciales DC, seleccionados de acuerdo con el intervalo de pasividad que aparece en su curva de polarización anódica. En el rango de potenciales estudiado, se han obtenido tres tipos de respuesta electroquímica, cada una con un diagrama de Nyquist característico. Los diagramas obtenidos se han simulado construyendo los correspondientes circuitos equivalentes. La evolución, con la polarización aplicada, de los valores de los elementos que componen cada circuito ha permitido definir el intervalo de potencial en el que la capa pasiva es estable, se forman picaduras metaestables, o se nuclean y crecen picaduras. Por

  6. Chemical characteristics of soluble aerosols over the central Himalayas: insights into spatiotemporal variations and sources.

    Science.gov (United States)

    Tripathee, Lekhendra; Kang, Shichang; Rupakheti, Dipesh; Cong, Zhiyuan; Zhang, Qianggong; Huang, Jie

    2017-11-01

    In order to investigate the spatial and temporal variations of aerosols and its soluble chemical compositions of the data gap zone in the central Himalayan region, aerosol samples were collected at four sites. The sampling location were characterized by four different categories, such as urban (Bode), semi-urban site in the northern Indo-Gangetic Plain (Lumbini), rural (Dhunche), and semiarid rural (Jomsom). A total of 230 aerosol samples were collected from four representative sites for a yearlong period and analyzed for water-soluble inorganic ions (WSIIs). The annual average aerosol mass concentration followed the sequence as Bode (238.24 ± 162.24 μg/m3)> Lumbini (161.14 ± 105.95 μg/m3)> Dhunche (112.40 ± 40.30 μg/m3)> Jomsom (78.85 ± 34.28 μg/m3), suggesting heavier particulate pollution in the urban and semi-urban sites. The total soluble ions contributed to 12.61-28.19% of TSP aerosol mass. The results revealed that SO42- and NO3- were the major anion and Ca2+ and NH4+ were the major cation influencing the aerosol composition over the central Himalayas. Calcium played a major role in neutralizing aerosol acidity followed by NH4+ at all the sites. The major compound of aerosol was (NH4)2SO4 and NH4HSO4 in the central Himalayas. Clear seasonality was observed at three observation sites, with higher concentrations during non-monsoon (dry periods) and lower during monsoon (wet period), suggesting washing out of aerosol particles by heavy precipitation during monsoon. In contrast, semiarid sites did not show the clear seasonal trend due to limited precipitation. Stationary sources were predominant over the mobile sources mostly in the remote sites. Principal component analysis confirmed that the major sources of WSIIs in the region were industrial emissions, fossil fuel and biomass burning, and crustal fugitive dusts. Nevertheless, transboundary aerosol transport over the region from polluted cities from south Asia could not be ignored as

  7. Lung flute improves symptoms and health status in COPD with chronic bronchitis: A 26 week randomized controlled trial.

    Science.gov (United States)

    Sethi, Sanjay; Yin, Jingjing; Anderson, Pamela K

    2014-01-01

    Chronic obstructive pulmonary disease (COPD) is characterized by mucus hypersecretion that contributes to disease related morbidity and is associated with increased mortality. The Lung Flute® is a new respiratory device that produces a low frequency acoustic wave with moderately vigorous exhalation to increase mucus clearance. We hypothesized that the Lung Flute, used on a twice daily basis will provide clinical benefit to patients with COPD with chronic bronchitis. We performed a 26 week randomized, non-intervention controlled, single center, open label trial in 69 patients with COPD and Chronic Bronchitis. The primary endpoint was change in respiratory symptoms measured with the Chronic COPD Questionnaire (CCQ). Secondary endpoints included health status, assessed by the St. George Respiratory questionnaire (SGRQ), BODE (Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity) index score and exacerbation frequency. While the control patients did not demonstrate any significant changes in the primary endpoint (CCQ change at 26 weeks of +0.01, p = 0.8), a trend (p = 0.08) to decrease (improvement) in the CCQ (-0.23 at 26 weeks) was seen with the Lung Flute. Furthermore, a significant improvement in the symptom domain of the CCQ was seen only with the lung flute (-0.42, p = 0.004). Health status (SGRQ) improvement, was also only seen with the Lung Flute (-3.23, p = 0.03). The BODE score increased in the control group (3.31 at baseline, 4.14 at 26 weeks), however it remained stable in the Lung Flute arm (3.16 at baseline and 26 weeks), with the changes from baseline being significantly different between the 2 arms (p = 0.01). There was a trend for less exacerbations in the Lung Flute group (p = 0.07). Adverse effects were minor, with only 1 patient discontinuing treatment because of lack of efficacy. Serious adverse effects seen were all determined to be unrelated to the device use. The Lung Flute is a safe and effective

  8. Antimicrobial Peptides from Plants

    Directory of Open Access Journals (Sweden)

    James P. Tam

    2015-11-01

    Full Text Available Plant antimicrobial peptides (AMPs have evolved differently from AMPs from other life forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the disulfides cross-braced plant AMPs as cystine-rich peptides to confer them with extraordinary high chemical, thermal and proteolytic stability. The cystine-rich or commonly known as cysteine-rich peptides (CRPs of plant AMPs are classified into families based on their sequence similarity, cysteine motifs that determine their distinctive disulfide bond patterns and tertiary structure fold. Cystine-rich plant AMP families include thionins, defensins, hevein-like peptides, knottin-type peptides (linear and cyclic, lipid transfer proteins, α-hairpinin and snakins family. In addition, there are AMPs which are rich in other amino acids. The ability of plant AMPs to organize into specific families with conserved structural folds that enable sequence variation of non-Cys residues encased in the same scaffold within a particular family to play multiple functions. Furthermore, the ability of plant AMPs to tolerate hypervariable sequences using a conserved scaffold provides diversity to recognize different targets by varying the sequence of the non-cysteine residues. These properties bode well for developing plant AMPs as potential therapeutics and for protection of crops through transgenic methods. This review provides an overview of the major families of plant AMPs, including their structures, functions, and putative mechanisms.

  9. A novel design of feedback control system for plasma horizontal position in IR-T1 tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Naghidokht, A.; Khodabakhsh, R. [Department of physics, Urmia University, Urmia (Iran, Islamic Republic of); Salar Elahi, A., E-mail: Salari_phy@yahoo.com [Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Ghoranneviss, M. [Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of)

    2016-06-15

    Determination of accurate plasma horizontal position during plasma discharge is essential to transport it to a control system based on feedback. By using the plasma-circuits linearized model, Proportional Integral Derivative (PID) based controllers and a first order transfer function representing the power supply (PS) dynamics of vertical coil system for IR-T1 tokamak, we analyzed step feedback response of the overall system of IR-T1 tokamak and corresponding Bode diagrams for two cases with and without the plasma resistance and the eddy currents distribution. Also we did experiments for determination of plasma horizontal displacement in this tokamak. This work is done by four magnetic probes that are installed on the circular contour of the tokamak. This data used as input to the feedback controller to validate the performance of it. Results of feedback response analysis show that the controller has good performance. Due to approximations in the controller design, construction, installation and implementation of the controller is necessary and this is the purpose of our future works.

  10. Policy responses to the European debt crisis treating the “symptoms” or the “disease”?

    Directory of Open Access Journals (Sweden)

    Antzoulatos Angelos A.

    2012-01-01

    Full Text Available The conventional narrative for the European debt crisis stresses three factors, namely, bad policies and profligacy in the afflicted countries - mostly southern ones, flaws in the EMU design, and wise policies in the northern frugal countries. This paper argues that the root causes of the crisis lie in the failure of many “safety valves” of market economies, at many levels of the society, both in the crisis countries and in the more “prudent” EMU countries, in an economic environment where unfettered finance can overwhelm even the biggest and best managed economies. Hence, the policy responses based on the conventional narrative are akin to treating the “symptoms”, not the “disease”. As such, they may be setting the foundations for a bigger crisis in the future by strengthening the always-present perverse incentives of many economic players and by proposing complex and unworkable regulatory and supervisory structures. This, together with the unequal sharing of the burden of adjustment - both across and within countries, bodes ill for the long-term prospects of EMU, despite that the aforementioned failures are not intrinsically related to the euro.

  11. A Two-Disk Extended Jeffcott Rotor Model Distinguishing a Shaft Crack from Other Rotating Asymmetries

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    Xi Wu

    2008-01-01

    Full Text Available A mathematical model of a cracked rotor and an asymmetric rotor with two disks representing a turbine and a generator is utilized to study the vibrations due to imbalance and side load. Nonlinearities typically related with a “breathing” crack are included using a Mayes steering function. Numerical simulations demonstrate how the variations of rotor parameters affect the vibration response and the effect of coupling between torsional and lateral modes. Bode, spectrum, and orbit plots are used to show the differences between the vibration signatures associated with cracked shafts versus asymmetric shafts. Results show how nonlinear lateral-torsional coupling shifts the resonance peaks in the torsional vibration response for cracked shafts and asymmetric rotors. The resonance peaks shift depending on the ratio of the lateral-to-torsional natural frequencies with the peak responses occurring at noninteger values of the lateral natural frequency. When the general nonlinear models used in this study are constrained to reduce to linear torsional vibration, the peak responses occur at commonly reported integer ratios. Full spectrum analyses of the X and Y vibrations reveal distinct vibration characteristics of both cracked and asymmetric rotors including reverse vibration components. Critical speeds and vibration orders predicted using the models presented herein include and extend diagnostic indicators commonly reported.

  12. Technocultural education

    Directory of Open Access Journals (Sweden)

    Lars Løvlie

    2006-12-01

    Full Text Available In this essay I try to describe the development of a traditional liberal education into a technological liberal one. I propose that we start by dropping the classical oppositions between man and animal, and man and machine; that we stop pitting morality against technology and rhetoric; and that we do away with the idea that ICT in our schools will necessarily tear the fabric of education apart. We should rather try and re-describe the idea of an unencumbered and independent self in terms of relational concepts, like the cyborg or more radically: like the self as interface. John Dewey led the way to this view a century ago, by coining the word intelligence as the name of educative interactions between man, animal and machine. The self as interface is a self of differences rather than identities. But that idea does not do away with our emplaced body, or our personal sense of self and identity. In the postmodern world, the cyborg is a migrant with the ability to interpret signs, understand symbols of power, see through rhetorical games, engage in argumentation, and in these activities partake in his or her own political education. The Internet nomad does not bode anarchy. He or she is the radically decentred subject that may well participate in Kant’s cosmopolitanism, Jürgen Habermas’ discourse ethics and Jacques Derrida’s deconstruction. –  But this is to go slightly beyond the text submitted here …

  13. Many Faces of Migrations

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    Milica Antić Gaber

    2013-12-01

    We believe that in the present thematic issue we have succeeded in capturing an important part of the modern European research dynamic in the field of migration. In addition to well-known scholars in this field several young authors at the beginning their research careers have been shortlisted for the publication. We are glad of their success as it bodes a vibrancy of this research area in the future. At the same time, we were pleased to receive responses to the invitation from representatives of so many disciplines, and that the number of papers received significantly exceeded the maximum volume of the journal. Recognising and understanding of the many faces of migration are important steps towards the comprehensive knowledge needed to successfully meet the challenges of migration issues today and even more so in the future. It is therefore of utmost importance that researchers find ways of transferring their academic knowledge into practice – to all levels of education, the media, the wider public and, of course, the decision makers in local, national and international institutions. The call also applies to all authors in this issue of the journal.

  14. Progress and delivery of health care in Bhutan, the Land of the Thunder Dragon and Gross National Happiness.

    Science.gov (United States)

    Tobgay, Tashi; Dorji, Tandin; Pelzom, Dorji; Gibbons, Robert V

    2011-06-01

    The Himalayan Kingdom of Bhutan is rapidly changing, but it remains relatively isolated, and it tenaciously embraces its rich cultural heritage. Despite very limited resources, Bhutan is making a concerted effort to update its health care and deliver it to all of its citizens. Healthcare services are delivered through 31 hospitals, 178 basic health unit clinics and 654 outreach clinics that provide maternal and child health services in remote communities in the mountains. Physical access to primary health care is now well sustained for more than 90% of the population. Bhutan has made progress in key health indicators. In the past 50 years, life expectancy increased by 18 years and infant mortality dropped from 102.8 to 49.3 per 1000 live births between 1984 and 2008. Bhutan has a rich medical history. One of the ancient names for Bhutan was 'Land of Medicinal Herbs' because of the diverse medicinal plants it exported to neighbouring countries. In 1967, traditional medicine was included in the National Health System, and in 1971, formal training for Drungtshos (traditional doctors) and sMenpas (traditional compounders) began. In 1982, Bhutan established the Pharmaceutical and Research Unit, which manufactures, develops and researches traditional herbal medicines. Despite commendable achievements, considerable challenges lie ahead, but the advances of the past few decades bode well for the future. © 2011 Blackwell Publishing Ltd.

  15. Conceptualizing Quality in Participatory Health Research: A Phenomenographic Inquiry

    Directory of Open Access Journals (Sweden)

    Jane Springett

    2016-05-01

    Full Text Available Participatory approaches to research are gaining popularity in health and wellness disciplines because of their potential to bridge gaps between research and practice and promote health equity. A number of guidelines have been developed to help research-practitioners gauge the quality of participatory health research (PHR. In light of the increasing popularization of this approach in the field of public health, there is a need to check in with current practitioners to see if their practices are still reflective of past guidelines. The aim of this study was to understand how research-practitioners currently conceptualize the quality of participatory health research in particular. Using phenomenographic inquiry, we interviewed 13 researchers who described their experience of PHR. We identified 15 categories of description and visually represented the relationship between the categories using an outcome space. Our findings suggest that conceptualizations of what is considered high quality PHR have remained consistent. This reliability bodes well for the development of quality criteria for participatory health research. We discuss implications for scaling up this study to compare quality criteria beyond a North American context. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1602274

  16. Joint trajectories for social and physical aggression as predictors of adolescent maladjustment: Internalizing symptoms, rule-breaking behaviors, and borderline and narcissistic personality features

    Science.gov (United States)

    UNDERWOOD, MARION K.; BERON, KURT J.; ROSEN, LISA H.

    2011-01-01

    This investigation examined the relation between developmental trajectories jointly estimated for social and physical aggression and adjustment problems at age 14. Teachers provided ratings of children's social and physical aggression in Grades 3, 4, 5, 6, and 7 for a sample of 255 children (131 girls, 21% African American, 52% European American, 21% Mexican American). Participants, parents, and teachers completed measures of the adolescent's adjustment to assess internalizing symptoms, rule-breaking behaviors, and borderline and narcissistic personality features. Results showed that membership in a high and rising trajectory group predicted rule-breaking behaviors and borderline personality features. Membership in a high desister group predicted internalizing symptoms, rule-breaking behaviors, and borderline and narcissistic personality features. The findings suggest that although low levels of social and physical aggression may not bode poorly for adjustment, individuals engaging in high levels of social and physical aggression in middle childhood may be at greatest risk for adolescent psychopathology, whether they increase or desist in their aggression through early adolescence. PMID:21532919

  17. Gene therapy of inherited retinopathies: a long and successful road from viral vectors to patients.

    Science.gov (United States)

    Colella, Pasqualina; Auricchio, Alberto

    2012-08-01

    Inherited retinopathies (IRs) are common and untreatable blinding conditions inherited mostly as monogenic due to mutations in genes expressed in retinal photoreceptors (PRs) and in retinal pigment epithelium (RPE). Over the last two decades, the retina has emerged as one of the most favorable target tissues for gene therapy given its small size and its enclosed and immune-privileged environment. Different types of viral vectors have been developed, especially those based on the adeno-associated virus (AAV), which efficiently deliver therapeutic genes to PRs or RPE upon subretinal injections. Dozens of successful proofs of concept of the efficacy of gene therapy for recessive and dominant IRs have been generated in small and large models that have paved the way to the first clinical trials using AAV in patients with Leber congenital amaurosis, a severe form of childhood blindness. The results from these initial trials suggest that retinal gene therapy with AAV is safe in humans, that vision can be improved in patients that have suffered from severe impairment of visual function, in some cases for decades, and that readministration of AAV to the subretinal space is feasible, effective, and safe. However, none of the trials could match the levels of efficacy of gene therapy observed in a dog model of the disease, suggesting that there is room for improvement. In conclusion, these results bode well for further testing of AAV-mediated retinal gene therapy in patients with other monogenic and complex forms of blindness.

  18. A Dark Energy Camera Search for an Optical Counterpart to the First Advanced LIGO Gravitational Wave Event GW150914

    Science.gov (United States)

    Soares-Santos, M.; Kessler, R.; Burger, E.; Annis, J.; Brout, D.; Buckley-Geer, E.; Chen, H.; Cowperthwaite, P. S.; Diehl, H.T.; Doctor, Z.; hide

    2016-01-01

    We report the results of a deep search for an optical counterpart to the gravitational wave (GW) event GW150914, the first trigger from the Advanced LIGO GW detectors. We used the Dark Energy Camera (DECam) to image a 102 deg(exp 2) area, corresponding to 38% of the initial trigger high-probability sky region and to 11% of the revised high-probability region. We observed in the i and z bands at 4-5, 7, and 24 days after the trigger. The median 5(sigma) point-source limiting magnitudes of our search images are i = 22.5 and z = 21.8 mag. We processed the images through a difference-imaging pipeline using templates from pre-existing Dark Energy Survey data and publicly available DECam data. Due to missing template observations and other losses, our effective search area subtends 40 deg(exp 2), corresponding to a 12% total probability in the initial map and 3% in the final map. In this area, we search for objects that decline significantly between days 4-5 and day 7, and are undetectable by day 24, finding none to typical magnitude limits of i = 21.5, 21.1, 20.1 for object colors (i-z)= 1, 0, -1, respectively. Our search demonstrates the feasibility of a dedicated search program with DECam and bodes well for future research in this emerging field.

  19. Severe mammal declines coincide with proliferation of invasive Burmese pythons in Everglades National Park.

    Science.gov (United States)

    Dorcas, Michael E; Willson, John D; Reed, Robert N; Snow, Ray W; Rochford, Michael R; Miller, Melissa A; Meshaka, Walter E; Andreadis, Paul T; Mazzotti, Frank J; Romagosa, Christina M; Hart, Kristen M

    2012-02-14

    Invasive species represent a significant threat to global biodiversity and a substantial economic burden. Burmese pythons, giant constricting snakes native to Asia, now are found throughout much of southern Florida, including all of Everglades National Park (ENP). Pythons have increased dramatically in both abundance and geographic range since 2000 and consume a wide variety of mammals and birds. Here we report severe apparent declines in mammal populations that coincide temporally and spatially with the proliferation of pythons in ENP. Before 2000, mammals were encountered frequently during nocturnal road surveys within ENP. In contrast, road surveys totaling 56,971 km from 2003-2011 documented a 99.3% decrease in the frequency of raccoon observations, decreases of 98.9% and 87.5% for opossum and bobcat observations, respectively, and failed to detect rabbits. Road surveys also revealed that these species are more common in areas where pythons have been discovered only recently and are most abundant outside the python's current introduced range. These findings suggest that predation by pythons has resulted in dramatic declines in mammals within ENP and that introduced apex predators, such as giant constrictors, can exert significant top-down pressure on prey populations. Severe declines in easily observed and/or common mammals, such as raccoons and bobcats, bode poorly for species of conservation concern, which often are more difficult to sample and occur at lower densities.

  20. Nano-Optomechanical Systems for Gas Chromatography.

    Science.gov (United States)

    Venkatasubramanian, Anandram; Sauer, Vincent T K; Roy, Swapan K; Xia, Mike; Wishart, David S; Hiebert, Wayne K

    2016-11-09

    Microgas chromatography (GC) is promising for portable chemical analysis. We demonstrate a nano-optomechanical system (NOMS) as an ultrasensitive mass detector in gas chromatography. Bare, native oxide, silicon surfaces are sensitive enough to monitor volatile organic compounds at ppm levels, while simultaneously demonstrating chemical selectivity. The NOMS is able to sense GC peaks from derivatized metabolites at physiological concentrations. This is an important milestone for small-molecule quantitation assays in next generation metabolite analyses for applications such as disease diagnosis and personalized medicine. The optical microring, which plays an important role in the nanomechanical signal transduction mechanism, can also be used as an analyte concentration sensor. Different adsorption kinetics regimes are realized at different temperatures allowing temporary condensation of the analyte onto the sensor surfaces. This effect amplifies the signal, resulting in a 1 ppb level limit of detection, without partition enhancement from absorbing media. This sensitivity bodes well for NOMS as universal, ultrasensitive detectors in micro-GC, breath analysis, and other chemical-sensing applications.

  1. Enhancing the rate capability of high capacity xLi{sub 2}MnO{sub 3} . (1 - x)LiMO{sub 2} (M = Mn, Ni, Co) electrodes by Li-Ni-PO{sub 4} treatment

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sun-Ho; Thackeray, Michael M. [Electrochemical Energy Storage Department, Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439 (United States)

    2009-04-15

    The rate capability of high capacity xLi{sub 2}MnO{sub 3} . (1 - x)LiMO{sub 2} (M = Mn, Ni, Co) electrodes for lithium-ion batteries has been significantly enhanced by stabilizing the electrode surface by reaction with a Li-Ni-PO{sub 4} solution, followed by a heat-treatment step. Reversible capacities of 250 mAh/g at a C/11 rate, 225 mAh/g at C/2 and 200 mAh/g at C/1 have been obtained from 0.5Li{sub 2}MnO{sub 3} . 0.5LiNi{sub 0.44}Co{sub 0.25}Mn{sub 0.31}O{sub 2} electrodes between 4.6 and 2.0 V. The data bode well for their implementation in batteries that meet the 40-mile range requirement for plug-in hybrid vehicles. (author)

  2. Enhancing the rate capability of high capacity xLi{sub 2}MnO{sub 3} {sm_bullet} (1-x)LiMO{sub 2} (M=Mn, Ni, Co) electrodes.

    Energy Technology Data Exchange (ETDEWEB)

    Kang, S.-H.; Thackeray, M. M.; Chemical Sciences and Engineering Division

    2009-04-01

    The rate capability of high capacity xLi{sub 2}MnO{sub 3} {center_dot} (1 - x)LiMO{sub 2} (M = Mn, Ni, Co) electrodes for lithium-ion batteries has been significantly enhanced by stabilizing the electrode surface by reaction with a Li-Ni-PO{sub 4} solution, followed by a heat-treatment step. Reversible capacities of 250 mAh/g at a C/11 rate, 225 mAh/g at C/2 and 200 mAh/g at C/1 have been obtained from 0.5Li{sub 2}MnO{sub 3} {center_dot} 0.5LiNi{sub 0.44}Co{sub 0.25}Mn{sub 0.31}O{sub 2} electrodes between 4.6 and 2.0 V. The data bode well for their implementation in batteries that meet the 40-mile range requirement for plug-in hybrid vehicles.

  3. Japan Women's University Multi-Career Path Support Model for Female Researchers (abstract)

    Science.gov (United States)

    Toyama, Yoshikazu; Kodate, Kashiko

    2009-04-01

    The overall goal of this project, funded by MEXT-Japan (Ministry of Education, Culture, Sports, and Technology), is to implement prototypical programs to foster and proactively engage female researchers. The project aims to provide comprehensive support for female researchers who wish to raise a family and pursue an academic career, and increase opportunities for female researchers to play more active roles. To achieve these objectives, three core actions are taken. First, with out-of-office/out-of-lab research support (ubiquitous research support), an assistant researcher is provided to help perform experiments while the ubiquitous researcher is out of the laboratory. A communication network is introduced to connect the laboratory with home to facilitate in-home research. Second, with human resources support, researchers' career paths, abilities, and experiences are accumulated in e-portfolios. This enables researchers coming from different fields of employment to pursue other career paths. Third, a follow-up survey and project planning are conducted. We believe through science education, science can be demystified, and made more accessible and fascinating for children. This would bode well for future generations. Alumni questionnaires show that 80% of respondents were very satisfied to have graduated with a science background.

  4. Morphology, transport characteristics and viscoelastic polymer chain confinement in nanocomposites based on thermoplastic potato starch and cellulose nanofibers from pineapple leaf.

    Science.gov (United States)

    Balakrishnan, Preetha; Sreekala, M S; Kunaver, Matjaž; Huskić, Miroslav; Thomas, Sabu

    2017-08-01

    Eco-friendly "green" nano composites were fabricated from potato starch and cellulose nanofibers from pineapple leaf. Nanocomposites of starch/cellulose nanofibers were prepared by solution mixing followed by casting. The investigation of the viscoelastic properties confirms starch macromolecular chain confinement around the nano scale cellulose surface, superior dispersion and very good interaction between thermoplastic starch and cellulose nanofibers. The degree of chain confinement was quantified. The chain confinement was associated with the immobilization of the starch macromolecular chains in the network formed by the nano-scale cellulose fibers as a result of hydrogen boding interactions. From the results, it was assumed that the starch glycerol system exhibits a heterogenous nature and cellulose nanofibers tend to move towards glycerol rich starch phase. Barrier properties also improved with the addition of nanofiller up to 3wt.% but further addition depreciated properties due to possible fiber agglomeration. The kinetics of diffusion was investigated and typical kinetic parameters were determined and found that the nanocomposites follow pseudo fickian behaviour. The outcome of the work confirms that the prepared nanocomposites films can be used as a swap for packaging applications. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Booming markets for Moroccan argan oil appear to benefit some rural households while threatening the endemic argan forest

    Science.gov (United States)

    Lybbert, Travis J.; Aboudrare, Abdellah; Chaloud, Deborah; Magnan, Nicholas; Nash, Maliha

    2011-01-01

    Morocco's argan oil is now the most expensive edible oil in the world. High-value argan markets have sparked a bonanza of argan activity. Nongovernmental organizations, international and domestic development agencies, and argan oil cooperatives aggressively promote the win–win aim of simultaneously benefiting local people and the health of the argan forest. This paper tests some of these win–win claims. Analysis of a panel of detailed household data suggests that the boom has enabled some rural households to increase consumption, increase their goat herds (which bodes poorly for the argan forest), and send their girls to secondary school. The boom has predictably made households vigilant guardians of fruit on the tree, but it has not incited investments in longer term tree and forest health. We evaluate landscape-level impacts of these changes using commune-level data on educational enrollment and normalized difference vegetation index data over the period from 1981 to 2009. The results of the mesoanalysis of enrollment are consistent with the microanalysis: the argan boom seems to have improved educational outcomes, especially for girls. Our normalized difference vegetation index analysis, however, suggests that booming argan prices have not improved the forest and may have even induced degradation. We conclude by exploring the dynamic interactions between argan markets, local institutions, rural household welfare, and forest conservation and sustainability. PMID:21873185

  6. The RNAi pathway plays a small part in Wolbachia-mediated blocking of dengue virus in mosquito cells.

    Science.gov (United States)

    Terradas, Gerard; Joubert, D Albert; McGraw, Elizabeth A

    2017-03-06

    Wolbachia pipientis is an insect endosymbiont known to limit the replication of viruses including dengue and Zika in their primary mosquito vector, Aedes aegypti. Wolbachia is being released into mosquito populations globally in a bid to control the diseases caused by these viruses. It is theorized that Wolbachia's priming of the insect immune system may confer protection against subsequent viral infection. Other hypotheses posit a role for competition between Wolbachia and viruses for host cellular resources. Using an A. aegypti cell line infected with Wolbachia, we tested the effects of targeting siRNAs against the major innate immune pathways on dengue virus loads. We show that while Wolbachia infection induces genes in the Toll, JAK/STAT and RNAi pathways, only reduced expression of RNAi leads to a rebound of dengue virus loads in Wolbachia-infected cells. The magnitude of the effect explained less than 10% of the total DENV load, demonstrating that blocking must be dependent on other factors in addition to the expression of RNAi. The findings bode well for the long-term stability of blocking given that immunity gene expression would likely be highly plastic and susceptible to rapid evolution.

  7. [The EPI-SCAN survey to assess the prevalence of chronic obstructive pulmonary disease in Spanish 40-to-80-year-olds: protocol summary].

    Science.gov (United States)

    Ancochea, J; Badiola, C; Duran-Tauleria, E; Garcia Rio, F; Miravitlles, M; Muñoz, L; Sobradillo, V; Soriano, J B

    2009-01-01

    Chronic obstructive pulmonary disease (COPD) causes considerable morbidity and mortality in Spain. The 1997 IBERPOC study, applying the old criteria of the European Respiratory Society, reported a COPD prevalence of 9.1% in the adult population of Spain. The Epidemiologic Study of COPD in Spain (EPI-SCAN) aims to determine the current prevalence of COPD in residents of Spain aged 40-80 years and to estimate changes over the past 10 years. Secondary objectives are, among others, to describe the current prevalence of smoking and changes in COPD prevalence relative to previous studies; to describe treatments received by patients, quality of life, and the BODE index (body mass index, obstruction of airflow, dyspnea, and exercise tolerance); and to measure inflammatory markers in blood and exhaled-breath condensate. EPI-SCAN is a population-based, cross-sectional epidemiologic study targeting the general population of Spain aged between 40 and 80 years. Participating centers were located in Barcelona, Burgos, Cordoba, Huesca, Madrid, Oviedo, Seville, Valencia, Vic, and Vigo. All subjects filled in an extensive questionnaire to collect social, demographic, and clinical information. Slow and forced spirometry tests before and after a bronchodilator test were also undertaken. Additionally, selected subjects performed a 6-minute walk test and answered generic and specific quality-of-life questionnaires, as well as an activities-of-daily-living questionnaire. Exhaled-breath condensate and blood samples were also collected from these subjects for measurement of inflammatory and other biomarkers.

  8. Effects of Fe(III) and quality of humic substances on As(V) distribution in freshwater: Use of ultrafiltration and Kohonen neural network.

    Science.gov (United States)

    Gontijo, Erik S J; Watanabe, Cláudia H; Monteiro, Adnívia S C; da Silva, Gilmare A; Roeser, Hubert M P; Rosa, Andre H; Friese, Kurt

    2017-12-01

    Humic substances (HS) are ubiquitous organic compounds able to affect mobility and availability of arsenic (As) in aquatic systems. Although it is known that associations between HS and As occur mainly via iron (Fe)-cationic bridges, the behaviour and distribution of this metalloid in HS- and Fe-rich environments is still not fully understood. In this paper, the quality of HS from different rivers in Brazil and Germany and its influence on the behaviour of As(V) under different Fe(III) concentrations were investigated. HS were extracted from four different rivers (Cascatinha, Holtemme, Selke and Warme Bode), characterised and fractionated into different molecular weight sizes (10, 5 and 1 kDa). Complexation tests were performed using an ultrafiltration system and 1 kDa membranes. All data was analysed using the Kohonen neural network (SOM - Self organising maps). All samples, except Selke, exhibited similar results of free As (plants) as precursor material. Most of the As and Fe was distributed in the fractions of higher (>10 kDa) and lower (<1 kDa) size. HS quality is an important factor to take into account when studying the behaviour of As in HS-rich environments. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Formation of the solar system by instability

    Science.gov (United States)

    Griv, Evgeny; Gedalin, Michael

    2005-02-01

    The early gas and dust protosolar nebula of the solar composition is considered analytically. A simultaneous formation of the sun and all the planets around it (≈ 5 × 10(9) yr ago) through a local gravitational Jeans-type instability of small-amplitude gravity perturbations in the nebula disk is suggested. It is shown that a collective process, forming the basis of the disk instability hypothesis, solves with surprising simplicity the two main problems of the dynamical characteristics of the system, which are associated with its observed spacing and orbital momentum distribution, namely, Bode's law on planet spacing and the concentration of angular momentum in the planets and mass in the sun. Besides, the analysis is found to imply the existence of new planets or other Kuiper-type belts of comets at mean distances from the sun of 87 AU, 151 AU, 261 AU, 452 AU, 781 AU (Mercury, Venus, ..., Asteroid belt, ..., Neptune, Kuiper belt, new planets or other Kuiper-type belts).

  10. CERN HUMAN RESSOURCES 1999 FRENCH VERSION NOW AVAIABLE

    CERN Multimedia

    Division du Personnel

    1999-01-01

    A report on CERN Human Resources is published once every two years. The version of the 1999 report is now available in French and in English: in your divisional secretariat for paper copieson the Web: http://www.cern.ch/HRreportIn its foreword, the Director-General addresses some key issues:'Many (…) key personnel are now steadily approaching retirement. (…) More efficient working methods and new technology can absorb not all the natural depletion. New blood is vital, and about a hundred new people are taken on each year'About the RSL programme, he says:'… More than 30 additional posts have been opened by this voluntary scheme. This programme displays the excellent mutual understanding that has been carefully built up between CERN management and staff. This harmonious atmosphere bodes well for continued success.'The Human Resources 1999 report gives information on a lot of subjects:general information on CERN's aim and the organisation of its operations,major changes in recent years...

  11. What is the Value of Embedding Artificial Emotional Prosody in Human-Computer Interactions? Implications for Theory and Design in Psychological Science.

    Science.gov (United States)

    Mitchell, Rachel L C; Xu, Yi

    2015-01-01

    In computerized technology, artificial speech is becoming increasingly important, and is already used in ATMs, online gaming and healthcare contexts. However, today's artificial speech typically sounds monotonous, a main reason for this being the lack of meaningful prosody. One particularly important function of prosody is to convey different emotions. This is because successful encoding and decoding of emotions is vital for effective social cognition, which is increasingly recognized in human-computer interaction contexts. Current attempts to artificially synthesize emotional prosody are much improved relative to early attempts, but there remains much work to be done due to methodological problems, lack of agreed acoustic correlates, and lack of theoretical grounding. If the addition of synthetic emotional prosody is not of sufficient quality, it may risk alienating users instead of enhancing their experience. So the value of embedding emotion cues in artificial speech may ultimately depend on the quality of the synthetic emotional prosody. However, early evidence on reactions to synthesized non-verbal cues in the facial modality bodes well. Attempts to implement the recognition of emotional prosody into artificial applications and interfaces have perhaps been met with greater success, but the ultimate test of synthetic emotional prosody will be to critically compare how people react to synthetic emotional prosody vs. natural emotional prosody, at the behavioral, socio-cognitive and neural levels.

  12. What is the Value of Embedding Artificial Emotional Prosody in Human–Computer Interactions? Implications for Theory and Design in Psychological Science

    Science.gov (United States)

    Mitchell, Rachel L. C.; Xu, Yi

    2015-01-01

    In computerized technology, artificial speech is becoming increasingly important, and is already used in ATMs, online gaming and healthcare contexts. However, today’s artificial speech typically sounds monotonous, a main reason for this being the lack of meaningful prosody. One particularly important function of prosody is to convey different emotions. This is because successful encoding and decoding of emotions is vital for effective social cognition, which is increasingly recognized in human–computer interaction contexts. Current attempts to artificially synthesize emotional prosody are much improved relative to early attempts, but there remains much work to be done due to methodological problems, lack of agreed acoustic correlates, and lack of theoretical grounding. If the addition of synthetic emotional prosody is not of sufficient quality, it may risk alienating users instead of enhancing their experience. So the value of embedding emotion cues in artificial speech may ultimately depend on the quality of the synthetic emotional prosody. However, early evidence on reactions to synthesized non-verbal cues in the facial modality bodes well. Attempts to implement the recognition of emotional prosody into artificial applications and interfaces have perhaps been met with greater success, but the ultimate test of synthetic emotional prosody will be to critically compare how people react to synthetic emotional prosody vs. natural emotional prosody, at the behavioral, socio-cognitive and neural levels. PMID:26617563

  13. Biological determinants of plant and crop productivity of flax (Linum usitatissimum L.

    Directory of Open Access Journals (Sweden)

    Tadeusz Zając

    2012-12-01

    Full Text Available In Poland the cultivation of the fibrous form of flax (Linum usitatissimum L. is dying out, but the acreage of its oilseed form, linseed, which provides seed (Semen lini used in therapy and being a source of -linolenic acid, is expanding. Nowadays, linseed is grown in 64 countries of the world, but yield levels in these countries vary greatly. Under European conditions, seed yield of linseed shows high variation, which is evidence of little knowledge of the biology of this plant and the lack of precise cultivation solutions in agricultural technologies used. A major reason is the difficulty in obtaining optimal crop density. A sparse crop results in low above-ground biomass yield, which is translated into insufficient crop yields. The selection of highly productive domestic and foreign varieties can partially increase linseed yield; apart from some domestic varieties, the Canadian cultivar 'Flanders' and the Hungarian cultivar 'Barbara' are positive examples in this respect. There is a possibility of effective selection at early stages of linseed breeding, which bodes well for the prospect of obtaining highly productive varieties with normal or very low -linolenic acid content.

  14. Temperature-dependent impedance spectroscopy of La0.8Sr0.2FeO3 nano-crystalline material

    Science.gov (United States)

    Kafa, C. A.; Triyono, D.; Laysandra, H.

    2017-04-01

    LaFeO3 is a material with perovskite structure which electrical properties frequently investigated. Research are done due to the exhibition of excellent gas sensing behavior through resistivity comparison from the p-type semiconductor. Sr doping on LaFeO3 or La1-xSrxFeO3 are able to improve the electrical conductivity through structural modification. Using Sr dopant concentration (x) of 0.2, La0.8Sr0.2FeO3 nano-crystal pellet was synthesized. The synthesis used sol-gel method, followed by gradual heat treatment and uniaxial compaction. XRD characterization shows that the structure of the sample is Orthorhombic Perovskite. Topography of the sample by SEM reveals grain and grain boundary existence with emerging agglomeration. The electrical properties of the material, as functions of temperature and frequency, were measured by Impedance Spectroscopy method using RLC meter, for temperatures of 303-373K. Through the Nyquist plot and Bode plot, the electrical conductivity of La0.8Sr0.2FeO3 is contributed by the grain and grain boundary. Finally, the electrical permittivities of La0.8Sr0.2FeO3 are increasing with temperature increase, with the highest achieved when measured at 1 kHz frequency.

  15. Effect of Sr substitution on the room temperature electrical properties of La1-xSrxFeO3 nano-crystalline materials

    Science.gov (United States)

    Kafa, C. A.; Triyono, D.; Laysandra, H.

    2017-07-01

    LaFeO3 is a material with Perovskite structure which electrical properties got investigated a lot, because as a p-type semiconductor it showed good gas sensing behavior through resistivity comparison. Sr doping on LaFeO3 is able to improve the electrical conductivity through structural modification. Using the Sr atoms doping concentration (x) from 0.1 to 0.4, La1-xSrxFeO3 nanocrystal pellets were synthesized using sol-gel method, followed by gradual heat treatment and uniaxial compaction. Structural analysis from XRD characterization shows that the structure of the materials is Orthorhombic Perovskite. The topography of the sample by SEM reveals grain and grain boundary existence with emerging agglomeration. The electrical properties of the material, as functions of frequency, were measured by Impedance Spectroscopy method using RLC meter. Through the Nyquist plot and Bode plot, the electrical conductivity of La1-xSrxFeO3 is contributed by grain and grain boundaries. It is reported that La0.6Sr0.4FeO3 sample has the most superior electrical conductivity of all samples, and the electrical permittivity of both La0.8Sr0.2FeO3 and La0.7Sr0.3FeO3 are the most stable.

  16. Frequency and time domain characteristics of digital control of electric vehicle in-wheel drives

    Directory of Open Access Journals (Sweden)

    Jarzebowicz Leszek

    2017-12-01

    Full Text Available In-wheel electric drives are promising as actuators in active safety systems of electric and hybrid vehicles. This new function requires dedicated control algorithms, making it essential to deliver models that reflect better the wheel-torque control dynamics of electric drives. The timing of digital control events, whose importance is stressed in current research, still lacks an analytical description allowing for modeling its influence on control system dynamics. In this paper, authors investigate and compare approaches to the analog and discrete analytical modeling of torque control loop in digitally controlled electric drive. Five different analytical models of stator current torque component control are compared to judge their accuracy in representing drive control dynamics related to the timing of digital control events. The Bode characteristics and stepresponse characteristics of the analytical models are then compared with those of a reference model for three commonly used cases of motor discrete control schemes. Finally, the applicability of the presented models is discussed.

  17. The growth of partnerships to support patient safety practice adoption.

    Science.gov (United States)

    Mendel, Peter; Damberg, Cheryl L; Sorbero, Melony E S; Varda, Danielle M; Farley, Donna O

    2009-04-01

    To document the numbers and types of interorganizational partnerships within the national patient safety domain, changes over time in these networks, and their potential for disseminating patient safety knowledge and practices. Self-reported information gathered from representatives of national-level organizations active in promoting patient safety. Social network analysis was used to examine the structure and composition of partnership networks and changes between 2004 and 2006. Two rounds of structured telephone interviews (n=35 organizations in 2004 and 55 in 2006). Patient safety partnerships expanded between 2004 and 2006. The average number of partnerships per interviewed organization increased 40 percent and activities per reported partnership increased over 50 percent. Partnerships increased in all activity domains, particularly dissemination and tools development. Fragmentation of the overall partnership network decreased and potential for information flow increased. Yet network centralization increased, suggesting vulnerability to partnership failure if key participants disengage. Growth in partnerships signifies growing strength in the capacity to disseminate and implement patient safety advancements in the U.S. health care system. The centrality of AHRQ in these networks of partnerships bodes well for its leadership role in disseminating information, tools, and practices generated by patient safety research projects.

  18. High Temperature Materials Laboratory Thirteenth Annual Report: October 1999 Through September 2000

    Energy Technology Data Exchange (ETDEWEB)

    Pasto, AE

    2001-11-07

    The High Temperature Materials Laboratory (HTML) User Program continued to work with industrial, academic, and governmental users this year, accepting 86 new projects and developing 50 new user agreements. The table on the following page presents the breakdown of these statistics. The figure on page 2 depicts the continued growth in user agreements and user projects. You may note that our total number of proposals is nearing 1000, and we expect to achieve this number in our first proposal review meeting of FY 2001. The large number of new agreements bodes well for the future. A list of proposals to the HTML follows this section; at the end of the report, we present a list of agreements between HTML and universities and industries, broken down by state. Program highlights this year included several outstanding user projects (some of which are discussed in later sections), the annual meeting of the HTML Programs Senior Advisory Committee, the completion of a formal Multiyear Program Plan (MYPP), and finalization of a purchase agreement with JEOL for a new-generation electron microscope.

  19. Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice.

    Science.gov (United States)

    Jiang, Wenzhi; Zhou, Huanbin; Bi, Honghao; Fromm, Michael; Yang, Bing; Weeks, Donald P

    2013-11-01

    The type II CRISPR/Cas system from Streptococcus pyogenes and its simplified derivative, the Cas9/single guide RNA (sgRNA) system, have emerged as potent new tools for targeted gene knockout in bacteria, yeast, fruit fly, zebrafish and human cells. Here, we describe adaptations of these systems leading to successful expression of the Cas9/sgRNA system in two dicot plant species, Arabidopsis and tobacco, and two monocot crop species, rice and sorghum. Agrobacterium tumefaciens was used for delivery of genes encoding Cas9, sgRNA and a non-fuctional, mutant green fluorescence protein (GFP) to Arabidopsis and tobacco. The mutant GFP gene contained target sites in its 5' coding regions that were successfully cleaved by a CAS9/sgRNA complex that, along with error-prone DNA repair, resulted in creation of functional GFP genes. DNA sequencing confirmed Cas9/sgRNA-mediated mutagenesis at the target site. Rice protoplast cells transformed with Cas9/sgRNA constructs targeting the promoter region of the bacterial blight susceptibility genes, OsSWEET14 and OsSWEET11, were confirmed by DNA sequencing to contain mutated DNA sequences at the target sites. Successful demonstration of the Cas9/sgRNA system in model plant and crop species bodes well for its near-term use as a facile and powerful means of plant genetic engineering for scientific and agricultural applications.

  20. Fractional order ultra low-speed position servo: improved performance via describing function analysis.

    Science.gov (United States)

    Luo, Ying; Chen, Yangquan; Pi, Youguo

    2011-01-01

    In a reference of the previous work, a new systematic design method for fractional order proportional and derivative (FOPD) controller is proposed for a class of typical second-order plants. Simulation and experimental results in the reference show that, the dynamic performance and robustness with the designed FOPD controller outperforms that with the optimized traditional integer order proportional integral (IOPI) controller at normal speed. Furthermore, it is found that, for the ultra low-speed position tracking with a significant friction effect, the tracking performance using the designed FOPD controller is much better than that using the optimized IOPI controller. However, the reason of this advantage is unclear. In this paper, using the describing function method and Bode plots analysis, the observed advantage of the designed FOPD controller over the optimized IOPI controller, for the nonlinear low-speed position tracking system with friction effect, is explained with the theoretical analysis. This explanation for the priority of the designed FOPD controller is consistently demonstrated by the extended experimental results in this paper. Copyright © 2010 ISA. Published by Elsevier Ltd. All rights reserved.

  1. Hemodynamic parameters of the isolated dog kidney as determined by a frequency response method.

    Science.gov (United States)

    Sato, T; Shirataka, M; Ikeda, N; Vega, D; Yamashiro, S M; Grodins, F S

    1980-01-01

    The isolated kidney of the dog was perfused with autologous blood through an oxygenator. Responses of arterial input pressure (PI), venous pressure (PV), and venous flow (UV) were measured during sinusoidal forcing of arterial inflow (UA) at 5 to 1,000 cpm superimposed on a steady-state flow level. Pre- (RA) and postglomerular (REV) resistances, and compliances of artery (CA) and glomeruli (CG) were estimated based on a network model and using the Bode diagram of gains PI/UA, UV/UA. The data were evaluated by the least square method with a digital computer. The mean values of the parameters normalized for the average weight of the kidney (64.5g) were: CA = 0.0027 ml/mmHg, CG = 0.088, RA = 0.45 mmHg . min/ml, and REV = 0.35. Mean arterial pressure (PA) and glomerular pressure (PG) were 111 and 50 mmHg, respectively. The regression lines of PG against PA were significantly different at high and low PA, this being taken as a manifestation of autoregulation of the renal circulation. PG values were less than those given by the classical study of Winton but close to those recently obtained on mutants rats with a direct puncture method by Brenner et al. It is concluded that the present study has given an experimental background with which we may continuously estimate, under more intact conditions, circulatory parameter values by monitoring pressures and flows which respond to external perturbations.

  2. Non-dimensional analysis of PEM fuel cell phenomena by means of AC impedance measurements

    Science.gov (United States)

    Iranzo, Alfredo; Muñoz, Miguel; Pino, Fco. Javier; Rosa, Felipe

    AC impedance or electrochemical impedance spectroscopy (EIS) is becoming a fundamental technique used by researchers and scientists in proton exchange membrane (PEM) fuel cell analysis and development. In this work, in situ impedance measurements are presented for a series of operating conditions in a 50 cm 2 fuel cell. The electrode charge transfer resistance was determined from the corresponding arcs of the Nyquist diagrams. The analyses were performed for H 2/O 2 and H 2/air operation at different stoichiometric factors and reactant gases humidification. Characteristic time scales of charge transfer processes at the different operating conditions were estimated from the corresponding Bode plots. These values were used for a non-dimensional analysis of the different fuel cell electrochemical and transport processes, namely electrochemical reaction versus GDL reactant transport. Fuel cell adapted Damkhöler numbers are thus presented, where the results indicate that the GDL diffusion transport is the limiting process for the cases under analysis, especially when air is used as oxidant. Additional analysis of channel convective mass transport versus GDL diffusive mass transport is also presented.

  3. Nonnatural amino acid incorporation into the methionine 214 position of the metzincin Pseudomonas aeruginosa alkaline protease

    Directory of Open Access Journals (Sweden)

    Honek John F

    2005-10-01

    Full Text Available Abstract Background The alkaline protease from Pseudomonas aeruginosa (AprA is a member of the metzincin superfamily of metalloendoproteases. A key feature of these proteases is a conserved methionine-containing 1,4-tight β turn at the base of the active site zinc binding region. Results To explore the invariant methionine position in this class of protease, incorporation of a nonnatural fluorinated methionine, L-difluoromethionine (DFM, into this site was accomplished. Although overproduction of the N-terminal catalytic fragment of AprA resulted in protein aggregates which could not be resolved, successful heterologous production of the entire AprA was accomplished in the presence and absence of the nonnatural amino acid. DFM incorporation was found to only slightly alter the enzyme kinetics of AprA. In addition, differential scanning calorimetry indicated no significant alteration in the thermal stability of the modified enzyme. Conclusion Although invariant in all metzincin proteases, the methionine 214 position in AprA can be successfully replaced by the nonnatural amino acid DFM resulting in little effect on protein structure and function. This study indicates that the increased size of the methyl group by the introduction of two fluorines is still sufficiently non-sterically demanding, and bodes well for the application of DFM to biophysical studies of protein structure and function in this class of protease.

  4. Long-term antibacterial characteristics and cytocompatibility of titania nanotubes loaded with Au nanoparticles without photocatalytic effects

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guomin [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China); Feng, Hongqing, E-mail: fenghongqing@binn.cas.cn [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China); Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST), Beijing 100083 (China); Jin, Weihong; Gao, Ang; Peng, Xiang; Li, Wan; Wu, Hao [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China); Li, Zhou [Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST), Beijing 100083 (China); Chu, Paul K., E-mail: paul.chu@cityu.edu.hk [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China)

    2017-08-31

    Highlights: • Au@TiO{sub 2}-NT shows long-term antibacterial effects without photocatalytical effects. • An ROS-free antibacterial process is confirmed. • Au@TiO{sub 2}-NT shows good compatibility with osteoblasts and does not induce ROS production. - Abstract: Au nanoparticles (NPs) can endow titania nanotubes (Au@TiO{sub 2}-NT) with light-independent antibacterial properties which bode well for in vivo application because of the dark environment inside tissues. In this work, the long-term antibacterial bactericidal properties and cytocompatibility of Au@TiO{sub 2}-NT without photocatalytic effects are studied in details. The materials exhibit antibacterial effects against Staphylococcus aureus according to antibacterial tests carried out for a total time of 21 days, which are normally long enough for early stage tissue healing after surgery. In addition, adhesion and proliferation of MC3T3-E1 osteoblasts on Au@TiO{sub 2}-NT reveal cytocompatibility comparable to that of TiO{sub 2}-NT. No reactive oxygen species (ROS) are detected from either the bacteria or MC3T3-E1 cells cultured on the Au@TiO{sub 2}-NT surface. The absence of ROS, long-term antibacterial properties, and cytocompatibility make Au@TiO{sub 2}-NT promising biomaterials in orthopedic devices and implants.

  5. Haptic feedback enhances rhythmic motor control by reducing variability, not improving convergence rate.

    Science.gov (United States)

    Ankarali, M Mert; Tutkun Sen, H; De, Avik; Okamura, Allison M; Cowan, Noah J

    2014-03-01

    Stability and performance during rhythmic motor behaviors such as locomotion are critical for survival across taxa: falling down would bode well for neither cheetah nor gazelle. Little is known about how haptic feedback, particularly during discrete events such as the heel-strike event during walking, enhances rhythmic behavior. To determine the effect of haptic cues on rhythmic motor performance, we investigated a virtual paddle juggling behavior, analogous to bouncing a table tennis ball on a paddle. Here, we show that a force impulse to the hand at the moment of ball-paddle collision categorically improves performance over visual feedback alone, not by regulating the rate of convergence to steady state (e.g., via higher gain feedback or modifying the steady-state hand motion), but rather by reducing cycle-to-cycle variability. This suggests that the timing and state cues afforded by haptic feedback decrease the nervous system's uncertainty of the state of the ball to enable more accurate control but that the feedback gain itself is unaltered. This decrease in variability leads to a substantial increase in the mean first passage time, a measure of the long-term metastability of a stochastic dynamical system. Rhythmic tasks such as locomotion and juggling involve intermittent contact with the environment (i.e., hybrid transitions), and the timing of such transitions is generally easy to sense via haptic feedback. This timing information may improve metastability, equating to less frequent falls or other failures depending on the task.

  6. Corrosion Behavior of High Pressure Die Cast Al-Ni and Al-Ni-Ca Alloys in 3.5% NaCl Solution

    Energy Technology Data Exchange (ETDEWEB)

    Arthanari, Srinivasan; Jang, Jae Cheol; Shin, Kwang Seon [Seoul National University, Seoul (Korea, Republic of)

    2017-06-15

    In this investigation corrosion behavior of newly developed high-pressure die cast Al-Ni (N15) and Al-Ni-Ca (NX1503) alloys was studied in 3.5% NaCl solution. The electrochemical corrosion behavior was evaluated using open circuit potential (OCP) measurement, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS) techniques. Potentiodynamic polarization results validated that NX1503 alloy exhibited lower corrosion current density (i{sub corr}) value (5.969 μA/cm{sup 2}) compared to N15 (7.387 μA/cm{sup 2}). EIS-Bode plots revealed a higher impedance (|Z|) value and maximum phase angle value for NX1503 than N15 alloy. Equivalent circuit curve fitting analysis revealed that surface layer (R{sub 1}) and charge transfer resistance (R{sub ct}) values of NX1503 alloy was higher compared to N15 alloy. Immersion corrosion studies were also conducted for alloys using fishing line specimen arrangement to simultaneously measure corrosion rates from weight loss (P{sub W}) and hydrogen volume (P{sub H}) after 72 hours and NX1503 alloy had lower corrosion rate compared to N15 alloy. The addition of Ca to N15 alloy significantly reduced the Al{sub 3}Ni intermetallic phase and further grain refinement may be attributed for reduction in the corrosion rate.

  7. Corrosion and Fretting of a Modular Hip System: A Retrieval Analysis of 60 Rejuvenate Stems.

    Science.gov (United States)

    De Martino, Ivan; Assini, Joseph B; Elpers, Marcella E; Wright, Timothy M; Westrich, Geoffrey H

    2015-08-01

    Femoral stems with dual-taper modularity were introduced to allow independent control of length, offset, and version. Corrosion and fretting related to micromotion at the neck-stem junction are thought to stimulate an adverse local tissue reaction (ALTR). Analysis of 60 consecutively retrieved modular-neck stem implants (Rejuvenate, Stryker) revised primarily for ALTR was done to determine the variables influencing corrosion and fretting patterns at the neck-stem interface. Taper damage evaluation was performed with stereomicrocopic analysis with two observers. Evidence of fretting and corrosion was seen at the neck-stem taper in all implants, including three implants revised for periprosthetic fractures within four weeks of the index surgery indicating that this process starts early. Femoral stems paired with the long overall neck lengths had significantly higher corrosion scores. Correlation of the corrosion severity at particular locations with the length of implantation suggests that the neck-stem junction experiences cyclic cantilever bending in vivo. The positive correlation between the length of implantation and fretting/corrosion scores bodes poorly for patients who still have this implant. Scanning electron microscopy on a subset of specimens was also performed to evaluate the black corrosion material. We strongly urge frequent follow-up exams for every patient with this particular modular hip stem. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Acoustic Emission Technique Applied in Textiles Mechanical Characterization

    Directory of Open Access Journals (Sweden)

    Rios-Soberanis Carlos Rolando

    2017-01-01

    Full Text Available The common textile architecture/geometry are woven, braided, knitted, stitch boded, and Z-pinned. Fibres in textile form exhibit good out-of-plane properties and good fatigue and impact resistance, additionally, they have better dimensional stability and conformability. Besides the nature of the textile, the architecture has a great role in the mechanical behaviour and mechanisms of damage in textiles, therefore damage mechanisms and mechanical performance in structural applications textiles have been a major concern. Mechanical damage occurs to a large extent during the service lifetime consequently it is vital to understand the material mechanical behaviour by identifying its mechanisms of failure such as onset of damage, crack generation and propagation. In this work, textiles of different architecture were used to manufacture epoxy based composites in order to study failure events under tensile load by using acoustic emission technique which is a powerful characterization tool due to its link between AE data and fracture mechanics, which makes this relation a very useful from the engineering point of view.

  9. Update on behavioral interventions for autism and developmental disabilities.

    Science.gov (United States)

    Kasari, Connie

    2015-04-01

    Given the explosion in published behavioral interventions over the past several years, this review highlights the latest trends over the past year (2014) for children with complex learning and developmental needs. There were virtually no rigorous intervention studies published on developmental disorders in which the cause of the disorder is well known. Nearly all studies focus on autism spectrum disorder. Trends over the past year emphasize modular interventions with design improvements including comparisons of two active treatments and larger and more diverse samples. Far more community-implemented treatments on understudied populations were conducted, including minimally verbal children, girls, very young infants, and low-resourced families. Finally, new pilot data on prevention and neural mechanisms were published. An uptick in the number of rigorous tests of different interventions conducted in real-world settings with outcomes focused on core deficits bodes well for wide dissemination and implementation by nonspecialists in the community. Pilot and uncontrolled data on prevention and mechanism await further rigorous testing before conclusions can be drawn.

  10. Stability Analysis for Compliant Constant-Force Compression Mechanisms

    Directory of Open Access Journals (Sweden)

    Ikechukwu Celestine UGWUOKE

    2009-12-01

    Full Text Available Stability analysis in compliant mechanism (CM design is of utmostimportance. From a practical point of view, a CM that is unstable is of nosignificance (has no practical value. Three useful plots were considered in theevaluation of each of the dynamic models of nine configurations of compliantconstant-force compression mechanisms (CCFCMs for their stabilitycharacteristics, which includes the polar plot based on the Routh-Hurwitzstability criterion, the Bode plot, and the Nyquist diagram which considersstability in the real frequency domain. Frequency-domain stability criterion isvery useful for determining suitable approaches to adjusting the CCFCMparameters in order to increase its relative stability. The results obtained showthat the CCFCMs investigated do exhibit higher relative stability for highervalues of damping ratio, and for zero damping ratio, all the CCFCMsinvestigated were unstable. The result also show that for the CCFCMsinvestigated to be stable, damping ratio must be greater than 0.03 (ξ > 0.03and depending on what attributes are most desirable, the CCFCM parameterscan be optimized to achieve the desired results. Nyquist criterion provides uswith suitable information concerning the absolute stability and furthermore,can be utilized to define and ascertain the relative stability of a system.

  11. Solubilization and stabilization of bacteriophage MS2 in organic solvents.

    Science.gov (United States)

    Johnson, Harvey R; Hooker, Jacob M; Francis, Matthew B; Clark, Douglas S

    2007-06-01

    Several techniques were examined for the solubilization of bacteriophage MS2 in organic solvents. Direct extraction of the MS2 from an aqueous phase into isooctane containing 2 mM AOT, a proven approach for the organic solubilization of many proteins, was not successful. However, predried samples of MS2 were solubilized through the direct addition of organic solvents containing 500 mM AOT. As an alternative procedure, reverse micelles containing aqueous solutions of MS2 were prepared in isooctane using AOT, dehydrated through solvent evaporation and azeotropic drying, and resolubilized in a solvent of choice. The structure and microenvironment of organic-solubilized MS2 were investigated by UV absorbance, the fluorescence emission of an attached solvatochromatic dye, tryptophan fluorescence, and atomic force microscopy, all of which contributed evidence for a fully assembled capsid in the organic solvent. The solubilized MS2 was derivatized with stearic acid in chloroform, illustrating that bioconjugation reactions can be performed on organic-solubilized capsids using reagents that are completely insoluble in water. Furthermore, the organic-solubilized phage remained infectious after heating at 90 degrees C for 20 min, whereas phage in aqueous buffer or dried with nitrogen were nonviable following the heat treatment protocol. The extended range of available chemical modifications and the enhanced thermal stability of the organic-solubilized capsids bodes well for the formulation of storage-stable vaccines predicated on reactions in or exposure to organic media. (c) 2006 Wiley Periodicals, Inc.

  12. Characterization of the Wheat Leaf Metabolome during Grain Filling and under Varied N-Supply

    Directory of Open Access Journals (Sweden)

    Elmien Heyneke

    2017-11-01

    Full Text Available Progress in improving crop growth is an absolute goal despite the influence multifactorial components have on crop yield and quality. An Avalon × Cadenza doubled-haploid wheat mapping population was used to study the leaf metabolome of field grown wheat at weekly intervals during the time in which the canopy contributes to grain filling, i.e., from anthesis to 5 weeks post-anthesis. Wheat was grown under four different nitrogen supplies reaching from residual soil N to a luxury over-fertilization (0, 100, 200, and 350 kg N ha−1. Four lines from a segregating doubled haploid population derived of a cross of the wheat elite cvs. Avalon and Cadenza were chosen as they showed pairwise differences in either N utilization efficiency (NUtE or senescence timing. 108 annotated metabolites of primary metabolism and ions were determined. The analysis did not provide genotype specific markers because of a remarkable stability of the metabolome between lines. We speculate that the reason for failing to identify genotypic markers might be due to insufficient genetic diversity of the wheat parents and/or the known tendency of plants to keep metabolome homeostasis even under adverse conditions through multiple adaptations and rescue mechanism. The data, however, provided a consistent catalogue of metabolites and their respective responses to environmental and developmental factors and may bode well for future systems biology approaches, and support plant breeding and crop improvement.

  13. The Relationships Between Muscle Power and Physical Activity in Older Men With Chronic Obstructive Pulmonary Disease.

    Science.gov (United States)

    Hernández, María; Zambom-Ferraresi, Fabrício; Cebollero, Pilar; Hueto, Javier; Cascante, José Antonio; Antón, María M

    2017-07-01

    The purpose of this study was to determine the potential relationship between muscle power of the lower extremities and the physical activity in older men with chronic obstructive pulmonary disease (COPD). Forty-four men (70.3 ± 6.7 years old) with moderate-to-severe COPD completed the 6-min walk test (6MWT), BODE (body mass index, obstruction, dyspnea, and exercise), a one-repetition maximum strength of the quadriceps femoris (1RMQF), and muscle power at 50% and 70% 1RMQF. Physical activity was measured using an accelerometer. The 6MWT was associated with muscle power at 50% 1RMQF (r = .40; P = .013) but not muscle power at 70% 1RMQF (r = .24; P = .15) or 1RMQF (r = .13; P = .44). Light-intensity activity was positively correlated with muscle power at 50% 1RMQF (r = .52; P = .001). Lower limb muscle power is associated with the 6MWT and light-intensity activities in older men with COPD.

  14. Characterization of implant materials in fetal bovine serum and sodium sulfate by electrochemical impedance spectroscopy. II. Coarsely sandblasted samples.

    Science.gov (United States)

    Contu, F; Elsener, B; Böhni, H

    2003-10-01

    Electrochemical impedance spectroscopy is used to investigate the corrosion resistance of coarsely sandblasted implant alloys, commercially pure titanium, Ti6Al4V, Ti6Al7Nb, and CoCrMo in 0.1M sodium sulfate and fetal bovine serum. Coarsely sandblasted samples have a heterogeneous surface constituted by a large number of protrusions and recessions. Impedance spectra collected in sodium sulfate present two time constants (maxima in the phase-angle of the bode plot) associated with the total surface and with the tips, respectively. In bovine serum, the two maxima in the impedance spectra cannot be distinguished because of the formation of an adsorption layer of organic molecules, which causes a decrease in the values of both the total and tips' capacitances as well as an increase in the polarization resistance. Ti6Al4V and Ti6Al7Nb show the highest corrosion rate both in serum and in sodium sulfate. Based on the capacitance values obtained in sodium sulfate, the real surface area of the coarsely sandblasted electrodes has been estimated relative to mechanically polished surfaces. The values of the effective electrode area correlate with the mechanical properties of the samples: in fact, the softest electrode (commercially pure titanium) shows the largest effective electrode area, whereas the hardest material (CoCrMo alloy) shows the smallest surface area. Copyright 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 246-254, 2003

  15. A low-temperature study of manganese-induced ferromagnetism and valence band convergence in tin telluride

    Energy Technology Data Exchange (ETDEWEB)

    Chi, Hang, E-mail: chihang@bnl.gov [Department of Physics, University of Michigan, Ann Arbor, Michigan 48109 (United States); Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Tan, Gangjian; Kanatzidis, Mercouri G. [Department of Chemistry, Northwestern University, Evanston, Illinois 60208 (United States); Li, Qiang [Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Uher, Ctirad [Department of Physics, University of Michigan, Ann Arbor, Michigan 48109 (United States)

    2016-05-02

    SnTe is renowned for its promise in advancing energy-related technologies based on thermoelectricity and for its topological crystalline insulator character. Here, we demonstrate that each Mn atom introduces ∼4 μ{sub B} (Bohr magneton) of magnetic moment to Sn{sub 1−x}Mn{sub x}Te. The Curie temperature T{sub C} reaches ∼14 K for x = 0.12, as observed in the field dependent hysteresis of magnetization and the anomalous Hall effect. In accordance with a modified two-band electronic Kane model, the light L-valence-band and the heavy Σ-valence-band gradually converge in energy with increasing Mn concentration, leading to a decreasing ordinary Hall coefficient R{sub H} and a favorably enhanced Seebeck coefficient S at the same time. With the thermal conductivity κ lowered chiefly via point defects associated with the incorporation of Mn, the strategy of Mn doping also bodes well for efficient thermoelectric applications at elevated temperatures.

  16. Oil palm monoculture induces drastic erosion of an Amazonian forest mammal fauna.

    Science.gov (United States)

    Mendes-Oliveira, Ana Cristina; Peres, Carlos A; Maués, Paula Cristina R de A; Oliveira, Geovana Linhares; Mineiro, Ivo G B; de Maria, Susanne L Silva; Lima, Renata C S

    2017-01-01

    Oil palm monoculture comprises one of the most financially attractive land-use options in tropical forests, but cropland suitability overlaps the distribution of many highly threatened vertebrate species. We investigated how forest mammals respond to a landscape mosaic, including mature oil palm plantations and primary forest patches in Eastern Amazonia. Using both line-transect censuses (LTC) and camera-trapping (CT), we quantified the general patterns of mammal community structure and attempted to identify both species life-history traits and the environmental and spatial covariates that govern species intolerance to oil palm monoculture. Considering mammal species richness, abundance, and species composition, oil palm plantations were consistently depauperate compared to the adjacent primary forest, but responses differed between functional groups. The degree of forest habitat dependency was a leading trait, determining compositional dissimilarities across habitats. Considering both the LTC and CT data, distance from the forest-plantation interface had a significant effect on mammal assemblages within each habitat type. Approximately 87% of all species detected within oil palm were never farther than 1300 m from the forest edge. Our study clearly reinforces the notion that conventional oil palm plantations are extremely hostile to native tropical forest biodiversity, which does not bode well given prospects for oil palm expansion in both aging and new Amazonian deforestation frontiers.

  17. Outcomes of a telemonitoring-based program (telEPOC) in frequently hospitalized COPD patients.

    Science.gov (United States)

    Esteban, Cristóbal; Moraza, Javier; Iriberri, Milagros; Aguirre, Urko; Goiria, Begoña; Quintana, José M; Aburto, Myriam; Capelastegui, Alberto

    2016-01-01

    The increasing prevalence of chronic diseases requires changes in health care delivery. In COPD, telemedicine appears to be a useful tool. Our objective was to evaluate the efficacy (in improving health care-resource use and clinical outcomes) of a telemonitoring-based program (telEPOC) in COPD patients with frequent hospitalizations. We conducted a nonrandomized observational study in an intervention cohort of 119 patients (Galdakao-Usansolo Hospital) and a control cohort of 78 patients (Cruces Hospital), followed up for 2 years (ClinicalTrials.gov identifier: NCT02528370). The inclusion criteria were two or more hospital admissions in the previous year or three or more admissions in the previous 2 years. The intervention group received telemonitoring plus education and controls usual care. Most participants were men (13% women), and the sample had a mean age of 70 years, forced expiratory volume in 1 second of 45%, Charlson comorbidity index score of 3.5, and BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index score of 4.1. In multivariate analysis, the intervention was independently related to lower rates of hospital admission (odds ratio [OR] 0.38, 95% confidence interval [CI] 0.27-0.54; Ptelemonitoring and education was able to reduce the health care-resource use and stabilize the clinical condition of frequently admitted COPD patients.

  18. Impedance Spectroscopic Investigation of Proton Conductivity in Nafion Using Transient Electrochemical Atomic Force Microscopy (AFM

    Directory of Open Access Journals (Sweden)

    Emil Roduner

    2012-06-01

    Full Text Available Spatially resolved impedance spectroscopy of a Nafion polyelectrolyte membrane is performed employing a conductive and Pt-coated tip of an atomic force microscope as a point-like contact and electrode. The experiment is conducted by perturbing the system by a rectangular voltage step and measuring the incurred current, followed by Fourier transformation and plotting the impedance against the frequency in a conventional Bode diagram. To test the potential and limitations of this novel method, we present a feasibility study using an identical hydrogen atmosphere at a well-defined relative humidity on both sides of the membrane. It is demonstrated that good quality impedance spectra are obtained in a frequency range of 0.2–1,000 Hz. The extracted polarization curves exhibit a maximum current which cannot be explained by typical diffusion effects. Simulation based on equivalent circuits requires a Nernst element for restricted diffusion in the membrane which suggests that this effect is based on the potential dependence of the electrolyte resistance in the high overpotential region.

  19. YACHTING CLUB

    CERN Multimedia

    YACHTING CLUB

    2010-01-01

    INTERNAL RAGATTE - BEST EVER ! If you missed Internal Regatta III on Sunday 11 July, you missed one of the best we can recall! The winds were about perfect, fairly stable Bf 2 with periodic gusts higher and the resulting capsizes to keep crews concentrating. It was extremely hot but we ran the usual three heats for keelboats and a record four for dinghies, catamarans - where there was another record, surely: a total of 11 boats in that class, of which three privately owned by members. And a final record: we calculate five boats were competing in their first-ever regatta. Results on the webpage. Surprisingly for those who remember regattas of a couple of years back, only three keelboats competed, so there would have been plenty of scope for less experienced members to come along regardless and probably find themselves a place. It is also noteworthy that the keelboat winner was Andrea Messina with an - ummm, may I say - less experienced crew himself! We hope this win bodes well for his forthcoming Transl&am...

  20. What is the value of embedding artificial emotional prosody in human computer interactions? Implications for theory and design in psychological science.

    Directory of Open Access Journals (Sweden)

    Rachel L. C. Mitchell

    2015-11-01

    Full Text Available In computerised technology, artificial speech is becoming increasingly important, and is already used in ATMs, online gaming and healthcare contexts. However, today’s artificial speech typically sounds monotonous, a main reason for this being the lack of meaningful prosody. One particularly important function of prosody is to convey different emotions. This is because successful encoding and decoding of emotions is vital for effective social cognition, which is increasingly recognised in human-computer interaction contexts. Current attempts to artificially synthesise emotional prosody are much improved relative to early attempts, but there remains much work to be done due to methodological problems, lack of agreed acoustic correlates, and lack of theoretical grounding. If the addition of synthetic emotional prosody is not of sufficient quality, it may risk alienating users instead of enhancing their experience. So the value of embedding emotion cues in artificial speech may ultimately depend on the quality of the synthetic emotional prosody. However, early evidence on reactions to synthesised nonverbal cues in the facial modality bodes well. Attempts to implement the recognition of emotional prosody into artificial applications and interfaces have perhaps been met with greater success, but the ultimate test of synthetic emotional prosody will be to critically compare how people react to synthetic emotional prosody vs. natural emotional prosody, at the behavioural, socio-cognitive and neural levels.

  1. Photophysical Behavior of Modified Xanthenic Dyes Embedded into Silsesquioxane Hybrid Films: Application in Photooxidation of Organic Molecules

    Directory of Open Access Journals (Sweden)

    Carolina V. Waiman

    2017-01-01

    Full Text Available Polymeric materials based on a bridged silsesquioxane with pendant dodecyl chains were synthesized and modified with different xanthenic dyes with the aim of developing a material with potential application in photooxidation of organic compounds. The employed dyes constitute a family of novel xanthenic chromophores with outstanding properties as singlet oxygen photosensitizers. The hybrid matrix was chosen for its enhanced properties such as flexibility and chemical resistance. The employed dyes were easily incorporated into the hybrid polymer obtaining homogeneous, transparent, and low-refractive-index materials. The polymeric films were characterized using UV-Vis absorption, fluorescence, and laser flash photolysis techniques. The ability of these materials to produce singlet oxygen was tested following the photooxidation of 9,10-dimethylanthracene which is a well-known chemical trap for singlet oxygen. High photooxidation efficiencies were observed for these materials, which present the advantage of being easily removed/collected from the solution where photooxidation takes place. While photobleaching of the incorporated dyes is commonly observed in the solution, it takes place very slowly when dyes are embedded in the hybrid matrix. These properties bode well for the potential use of these materials in novel wastewater purification strategies.

  2. Marginal integrity evaluation of dental composite using optical coherence tomography

    Science.gov (United States)

    Stan, Adrian-Tudor; Cojocariu, Andreea-Codruta; Antal, Anca Adriana; Topala, Florin; Sinescu, Cosmin; Negrutiu, Meda Lavinia; Duma, Virgil-Florin; Podoleanu, Adrian Gh.

    2016-03-01

    In clinical dental practice it is often difficult or even impossible to distinguish and control interfacial adhesive defects from adhesive restorations using visual inspection or other traditional diagnostic methods. Nonetheless, non-invasive biomedical imaging methods like Optical Coherence Tomography (OCT) may provide a better view in this diagnostic outline. The aim of this study is to explore evaluations of the marginal adaptation of class I resin composites restorations using Time Domain (TD) OCT. Posterior human teeth have been chosen for this study. The teeth were stored in 0.9% physiological saline solution prior to use. A classical round-shaped class I cavity was prepared and cavities were restored with Charisma Diamond composite by Heraeus Kulzer and using a system of etch and rinse boding. The specimens were subjected to water storage and then to thermo-cycling. Three dimensional (3-D) scans of the restoration were obtained using a TD-OCT system centered at a 1300 nm wavelength. Open marginal adaptation at the interfaces and gaps inside the composite resins materials were identified using the proposed method. In conclusion, OCT has numerous advantages which justify its use for in vitro, as well as for in vivo studies. It can therefore be considered for non-invasive and fast detection of gaps at the restoration interface.

  3. Experimental Study on the Vibration of an Overhung Rotor with a Propagating Transverse Crack

    Directory of Open Access Journals (Sweden)

    S.A. Adewusi

    2002-01-01

    Full Text Available This paper presents an experimental study on the dynamic response of an overhung rotor with a propagating transverse crack. The effects of a propagating transverse crack and side load on the dynamic response of an overhung rotor are investigated in order to identify vibration signatures of a propagating crack in rotating shafts. Startup and steady state vibration signatures were analyzed and presented in the form of Bode plots, Frequency Spectrum Cascades, Frequency Spectrum Waterfalls and orbits. The startup results showed that crack reduces the critical speed and increases the vibration amplitude of the rotor system. It also excites 2X vibration in the startup vibration signatures. The steady state results showed that the propagating crack produces changes in vibration amplitudes of 1X and 2X vibration harmonics and excites 3X harmonic just before fracture. During crack propagation, 1X amplitude may increase or decrease depending on the location of the crack and the direction of vibration measurement while 2X amplitude always increases. The steady state vibration signal of a propagating crack also produces a two-loop orbit.

  4. Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia.

    Science.gov (United States)

    Okolo, Onyemaechi N; Johnson, Ariel C; Yun, Seongseok; Arnold, Stacy J; Anwer, Faiz

    2017-08-01

    Waldenström macroglobulinemia (WM) is a lymphoproliferative lymphoma that is characterized by monoclonal immunoglobulin M (IgM) protein and bone marrow infiltration. Its incidence is rare and rarer still is its ability to transform to a B-cell lymphoma, particularly the aggressive diffuse large B-cell lymphoma, which bodes a poor prognosis. When transformation includes mutations of MYC, BCL-2 and/or BCL-6, it is known as a 'double hit' or 'triple hit' lymphoma respectively. This paper presents a rare case of WM with mutations positive for MYC and BCL2, making it a case of double hit B-cell lymphoplasmacytic lymphoma with plasmatic differentiation without morphological transformation to aggressive histology like DLBCL. The paper also broadens to include discussions on current topics in the classification, diagnosis, possible causes of transformation, and treatment of WM, including transformation to double hit lymphoma. The significance of this case lies in that the presence of double hit lymphoma-like genetic mutations in WM have not been previously described in the literature and potentially such changes are harbinger of extra-nodal presentation, aggressive growth, and possibly poor prognosis, if data from other double-hit lymphoma are extrapolated.

  5. Intravesical Foreign Body: Tertiary care center experience from Pakistan.

    Science.gov (United States)

    Soomro, Hussam Uddin; Jalbani, Imran; Faruqui, Nuzhat

    2016-10-01

    Foreign body in bladder is relatively uncommon condition with variable presentations. Literature is limited to case reports and small series from region. Therefore, we planned this study to review our experience regarding intravesical foreign body. This retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised 14 patients having intravesical foreign bodies from March 1989 to March 2013. Demographics, presentation, mode of insertion, type of foreign body and management were noted. Of the 11(78.6%) patients included in the study, 10(90.9%) patients were male and 1(9.1%) was female. The mean age was 51± 20 years. In 5(45.5%) patients, foreign bodies reached bladder by iatrogenic route followed by self-insertion in 4(36.4%) patients. Retrieved foreign bodes included piece of Foley\\'s catheter, electric wire, ureteric stent, plastic material, double-J stent pusher, Endo gastrointestinal (GI) staples, sticks of broom and bomb shrapnel. All patients were managed successfully with endoscopic removal. However, 5(45.5%) patients required additional urological procedures. This could represent a urologic challenge. Careful history and symptoms could lead to further investigations.

  6. Measurement of mechanical properties of metallic glass at elevated temperature using sonic resonance method

    Science.gov (United States)

    Kaluvan, Suresh; Zhang, Haifeng; Mridha, Sanghita; Mukherjee, Sundeep

    2017-04-01

    Bulk metallic glasses are fully amorphous multi-component alloys with homogeneous and isotropic structure down to the atomic scale. Some attractive attributes of bulk metallic glasses include high strength and hardness as well as excellent corrosion and wear resistance. However, there are few reports and limited understanding of their mechanical properties at elevated temperatures. We used a nondestructive sonic resonance method to measure the Young's modulus and Shear modulus of a bulk metallic glass, Zr41.2Ti13.8Cu12.5Ni10Be22.5, at elevated temperatures. The measurement system was designed using a laser displacement sensor to detect the sonic vibration produced by a speaker on the specimen in high-temperature furnace. The OMICRON Bode-100 Vector Network Analyzer was used to sweep the frequency and its output was connected to the speaker which vibrated the material in its flexural mode and torsional modes. A Polytec OFV-505 laser vibrometer sensor was used to capture the vibration of the material at various frequencies. The flexural and torsional mode frequency shift due to the temperature variation was used to determine the Young's modulus and Shear modulus. The temperature range of measurement was from 50°C to 350°C. The Young's modulus was found to reduce from 100GPa to 94GPa for the 300°C temperature span. Similarly, the Shear modulus decreased from 38.5GPa at 50°C to 36GPa at 350°C.

  7. Reabilitação pulmonar em longo prazo na doença pulmonar obstrutiva crônica (DPOC

    Directory of Open Access Journals (Sweden)

    Cintia Laura Pereira de Araújo

    2014-04-01

    Full Text Available Introdução: A Doença Pulmonar Obstrutiva Crônica (DPOC prejudica o estado funcional, com consequente limitação das Atividades de Vida Diária (AVD. Este estudo teve como objetivo investigar o efeito de um programa de Reabilitação Pulmonar (RP, em longo prazo, no estado funcional, na dispneia e no índice BODE em pacientes com DPOC. Relato de caso: Trata-se de um estudo retrospectivo e documental, com análise dos prontuários de cinco pacientes participantes de um programa de RP por um ano. Destes prontuários foram coletados dados referentes às avaliações: espirometria, Índice de Massa Corporal (IMC, escalas London Chest Activity of Daily Living (LCADL e Medical Research Council e (MRC teste de caminhada de seis minutos. Após um ano participando do programa de exercício físico, a maioria dos pacientes apresentou maior capacidade funcional, menor dispneia e redução no risco de mortalidade. Conclusão: Um ano de RP parece ter função de manutenção da melhora da capacidade funcional de pacientes com DPOC, após 24 sessões de treinamento.

  8. Booming markets for Moroccan argan oil appear to benefit some rural households while threatening the endemic argan forest.

    Science.gov (United States)

    Lybbert, Travis J; Aboudrare, Abdellah; Chaloud, Deborah; Magnan, Nicholas; Nash, Maliha

    2011-08-23

    Morocco's argan oil is now the most expensive edible oil in the world. High-value argan markets have sparked a bonanza of argan activity. Nongovernmental organizations, international and domestic development agencies, and argan oil cooperatives aggressively promote the win-win aim of simultaneously benefiting local people and the health of the argan forest. This paper tests some of these win-win claims. Analysis of a panel of detailed household data suggests that the boom has enabled some rural households to increase consumption, increase their goat herds (which bodes poorly for the argan forest), and send their girls to secondary school. The boom has predictably made households vigilant guardians of fruit on the tree, but it has not incited investments in longer term tree and forest health. We evaluate landscape-level impacts of these changes using commune-level data on educational enrollment and normalized difference vegetation index data over the period from 1981 to 2009. The results of the mesoanalysis of enrollment are consistent with the microanalysis: the argan boom seems to have improved educational outcomes, especially for girls. Our normalized difference vegetation index analysis, however, suggests that booming argan prices have not improved the forest and may have even induced degradation. We conclude by exploring the dynamic interactions between argan markets, local institutions, rural household welfare, and forest conservation and sustainability.

  9. Dissecting Halo Components in IFU Data

    Directory of Open Access Journals (Sweden)

    Michael Merrifield

    2017-05-01

    Full Text Available While most astronomers are now familiar with tools to decompose images into multiple components such as disks, bulges, and halos, the equivalent techniques for spectral data cubes are still in their infancy. This is unfortunate, as integral field unit (IFU spectral surveys are now producing a mass of data in this format, which we are ill-prepared to analyze effectively. We have therefore been developing new tools to separate out components using this full spectral data. The results of such analyses will prove invaluable in determining not only whether such decompositions have an astrophysical significance, but, where they do, also in determining the relationship between the various elements of a galaxy. Application to a pilot study of IFU data from the cD galaxy NGC 3311 confirms that the technique can separate the stellar halo from the underlying galaxy in such systems, and indicates that, in this case, the halo is older and more metal poor than the galaxy, consistent with it forming from the cannibalism of smaller satellite galaxies. The success of the method bodes well for its application to studying the larger samples of cD galaxies that IFU surveys are currently producing.

  10. Assessing health status in COPD. A head-to-head comparison between the COPD assessment test (CAT and the clinical COPD questionnaire (CCQ

    Directory of Open Access Journals (Sweden)

    Tsiligianni Ioanna G

    2012-05-01

    Full Text Available Abstract Background Health status provides valuable information, complementary to spirometry and improvement of health status has become an important treatment goal in COPD management. We compared the usefulness and validity of the COPD Assessment Test (CAT and the Clinical COPD Questionnaire (CCQ, two simple questionnaires, in comparison with the St. George Respiratory Questionnaire (SGRQ. Methods We administered the CAT, CCQ and SGRQ in patients with COPD stage I-IV during three visits. Spirometry, 6 MWT, MRC scale, BODE index, and patients perspectives on questionnaires were recorded in all visits. Standard Error of Measurement (SEM was used to calculate the Minimal Clinical Important Difference (MCID of all questionnaires. Results We enrolled 90 COPD patients. Cronbach's alpha for both CAT and CCQ was high (0.86 and 0.89, respectively. Patients with severe COPD reported worse health status compared to milder subgroups. CAT and CCQ correlated significantly (rho =0.64, p  Conclusions The CAT and CCQ have similar psychometric properties with a slight advantage for CCQ based mainly on patients’ preference and are both valid and reliable questionnaires to assess health status in COPD patients.

  11. Inflammatory and repair serum biomarker pattern. Association to clinical outcomes in COPD

    Directory of Open Access Journals (Sweden)

    Pinto-Plata Victor

    2012-08-01

    Full Text Available Abstract Background The relationship between serum biomarkers and clinical expressions of COPD is limited. We planned to further describe this association using markers of inflammation and injury and repair. Methods We studied lung function, comorbidities, exercise tolerance, BODE index, and quality of life in 253 COPD patients and recorded mortality over three years. Serum levels of Interleukins 6,8 and16, tumor necrosis factor alpha (TNF α [inflammatory panel], vascular endothelial growth factor (VEGF, and matrix metalloproteinase 9 (MMP-9 [injury and repair panel] and pulmonary and activation-regulated chemokine (PARC/CCL-18 and monocyte chemotactic protein 1 (MCP-1/CCL2 [chemoattractant panel] were measured. We related the pattern of the biomarker levels to minimal clinically important differences (MCID using a novel visualization method [ObServed Clinical Association Results (OSCAR plot]. Results Levels of the inflammatory markers IL-6, TNF α were higher and those of injury and repair lower (p  Conclusions In COPD, serum biomarkers of inflammation and repair are distinctly associated with important clinical parameters and survival.

  12. Resveratrol in prevention and treatment of common clinical conditions of aging

    Directory of Open Access Journals (Sweden)

    M Andrea Markus

    2008-06-01

    Full Text Available M Andrea Markus, Brian J MorrisSchool of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, AustraliaAbstract: Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer’s disease. We present the latest molecular findings that account for the beneficial actions of resveratrol. The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases. While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.Keywords: resveratrol, longevity, SIRT, wine, aging, cancer

  13. Neurophysiological aspects and their relationship to clinical and functional impairment in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Rocco, Carolina Chiusoli de Miranda; Sampaio, Luciana Maria Malosá; Stirbulov, Roberto; Corrêa, João Carlos Ferrari

    2011-01-01

    The purpose was to assess functional (balance L-L and A-P displacement, sit-to-stand test (SST) and Tinetti scale - balance and gait) and neurophysiological aspects (patellar and Achilles reflex and strength) relating these responses to the BODE Index. The neurophysiological alterations found in patients with chronic obstructive pulmonary disease (COPD) are associated with the severity of the disease. There is also involvement of peripheral muscle which, in combination with neurophysiological impairment, may further compromise the functional activity of these patients. A cross-sectional study design was used. Twenty-two patients with moderate to very severe COPD (> 60 years) and 16 age-matched healthy volunteers served as the control group (CG). The subjects performed spirometry and several measures of static and dynamic balance, monosynaptic reflexes, peripheral muscle strength, SST and the 6-minute walk test. The individuals with COPD had a reduced reflex response, 36.77 ± 3.23 (p Tinetti scale, 26.86 ± 1.69 (p Tinetti scale), r = 0.59 (p test, r = 0.78 (p Tinetti scale and the SST. Both are functional tests, easy to administer, low cost and feasible, especially the SST. These results suggest a worse prognosis; however, more studies are needed to identify the causes of these changes and the repercussions that could result in their activities of daily living.

  14. An electrochemical study of corrosion protection by primer-topcoat systems on 4130 steel with ac impedance and dc methods

    Science.gov (United States)

    Mendrek, M. J.; Higgins, R. H.; Danford, M. D.

    1988-01-01

    To investigate metal surface corrosion and the breakdown of metal protective coatings, the ac impedance method is applied to six systems of primer coated and primer topcoated 4130 steel. Two primers were used: a zinc-rich epoxy primer and a red lead oxide epoxy primer. The epoxy-polyamine topcoat was used in four of the systems. The EG and G-PARC Model 368 ac impedance measurement system, along with dc measurements with the same system using the polarization resistance method, were used to monitor changing properties of coated 4230 steel disks immersed in 3.5 percent NaCl solutions buffered at pH 5.4 over periods of 40 to 60 days. The corrosion system can be represented by an electronic analog called an equivalent circuit consisting of resistors and capacitors in specific arrangements. This equivalent circuit parallels the impedance behavior of the corrosion system during a frequency scan. Values for the resistors and capacitors, that can be assigned in the equivalent circuit following a least-squares analysis of the data, describe changes that occur on the corroding metal surface and in the protective coatings. Two equivalent circuits have been determined that predict the correct Bode phase and magnitude of the experimental sample at different immersion times. The dc corrosion current density data are related to equivalent circuit element parameters. Methods for determining corrosion rate with ac impedance parameters are verified by the dc method.

  15. Modelling Groundwater-Surface water Exchange and its Implications on Groundwater Quality

    Science.gov (United States)

    Maier, Uli; Wiesner, Victoria; Trauth, Nico; Musolff, Andreas; Fleckenstein, Jan

    2014-05-01

    Hydrogeochemical interactions are still posing a significant challenge for the assessment of water quality at the catchment scale. Numerical modelling of water quality is still restricted by computer power and parameter uncertainty at larger scales and is demanding further research regarding the influence of surface water on groundwater resources. The Selke river is a tributary to the larger Bode river in the surroundings of the Harz mountains in northern Germany. Hydrology and water quality is monitored at a well-equipped field investigation site, which is accompanied by numerical modeling work at different scales. The site consists of approximately two km2 of river, alluvial sediments and gently inclined hillslopes. River stage, water levels and saturation in surface water, unsaturated zone and groundwater were simulated for quasi steady state conditions and a transient, climate-data driven run over the course of a year. Of particular interest are the observed model results for the hotspots of hydraulic and geochemical interaction, between the river, its alluvial plain and the hyporheic zone. Model results will be used to guide the further instrumentation of the field investigation. Such hotspots of interaction between environmental compartments are discussed, as well as travel time distributions from particle tracking and dispersive approaches. Groundwater nitrate contamination and its removal potential will be linked to the water exchange behavior.

  16. Coherence-limited solar power conversion: the fundamental thermodynamic bounds and the consequences for solar rectennas

    Science.gov (United States)

    Mashaal, Heylal; Gordon, Jeffrey M.

    2014-10-01

    Solar rectifying antennas constitute a distinct solar power conversion paradigm where sunlight's spatial coherence is a basic constraining factor. In this presentation, we derive the fundamental thermodynamic limit for coherence-limited blackbody (principally solar) power conversion. Our results represent a natural extension of the eponymous Landsberg limit, originally derived for converters that are not constrained by the radiation's coherence, and are irradiated at maximum concentration (i.e., with a view factor of unity to the solar disk). We proceed by first expanding Landsberg's results to arbitrary solar view factor (i.e., arbitrary concentration and/or angular confinement), and then demonstrate how the results are modified when the converter can only process coherent radiation. The results are independent of the specific power conversion mechanism, and hence are valid for diffraction-limited as well as quantum converters (and not just classical heat engines or in the geometric optics regime). The derived upper bounds bode favorably for the potential of rectifying antennas as potentially high-efficiency solar converters.

  17. Evolution and structure of sustainability science.

    Science.gov (United States)

    Bettencourt, Luís M A; Kaur, Jasleen

    2011-12-06

    The concepts of sustainable development have experienced extraordinary success since their advent in the 1980s. They are now an integral part of the agenda of governments and corporations, and their goals have become central to the mission of research laboratories and universities worldwide. However, it remains unclear how far the field has progressed as a scientific discipline, especially given its ambitious agenda of integrating theory, applied science, and policy, making it relevant for development globally and generating a new interdisciplinary synthesis across fields. To address these questions, we assembled a corpus of scholarly publications in the field and analyzed its temporal evolution, geographic distribution, disciplinary composition, and collaboration structure. We show that sustainability science has been growing explosively since the late 1980s when foundational publications in the field increased its pull on new authors and intensified their interactions. The field has an unusual geographic footprint combining contributions and connecting through collaboration cities and nations at very different levels of development. Its decomposition into traditional disciplines reveals its emphasis on the management of human, social, and ecological systems seen primarily from an engineering and policy perspective. Finally, we show that the integration of these perspectives has created a new field only in recent years as judged by the emergence of a giant component of scientific collaboration. These developments demonstrate the existence of a growing scientific field of sustainability science as an unusual, inclusive and ubiquitous scientific practice and bode well for its continued impact and longevity.

  18. ALICE on the move

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    A new management, new modules for its sub-detectors and an increased capacity to probe the properties of the quark-gluon plasma. The new year bodes well for ALICE and ion physics as quarks and gluons prepare to unveil their most profound mysteries.   Installation of one of the new EMCal modules in the detector. Paolo Giubellino, the new ALICE spokesperson, talks with enthusiasm about what has already been done by the ALICE collaboration and what is yet to come. He has recently taken over from Jurgen Schukraft, who led the collaboration from its earliest beginnings. “We had a very exciting first year of operation, with many interesting results coming up in a very short space of time,” says Giubellino, a heavy-ion-physics expert from the Italian National Institute for Nuclear Physics (see box for details). “The Christmas technical stop wasn’t a break for us as we upgraded the detector, completing the installation of the electromagnetic calorimeter (E...

  19. Study of control system for self-commutated converter compensator. Jireishiki muko denryoku hosho sochi no seigyo hoshiki no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, K.; Nakajima, T. (The Tokyo Electric Power Co. Inc., Tokyo (Japan)); Konishi, H.; Nakamura, T. (Hitachi, Ltd., Tokyo (Japan))

    1992-01-20

    A new control system with high response speed for self -commutated Static Var Compensator(SVC) has been developed. This system does not require phase detection, obtains real and imaginary components of instantaneous power from AC voltage and AC current of the system, and conducts vector control(VQ vector control) using these components. The operation process and the control principle in the VQ vector control system acre explained by block diagram. Then, responses of the system in each case of system start-up operation, sudden change of AC voltage magnitude, sudden phase change, and one phase line grounded fault were investigated by digital simulations of Electro-Magnetic Transients Program(EMTP). As a result, effectiveness of the control system by this system was verified. Sampling periods of input signals for digitalizing the control system were also examined by digital simulations and Bode diagram. Results of both methods agreed well with each other, and it was found that O.3ms or less is a suitable value. 6 refs., 12 figs.

  20. Influence of surface layer on mechanical and corrosion properties of nickel-titanium orthodontic wires.

    Science.gov (United States)

    Katić, Višnja; Curković, Helena Otmačić; Semenski, Damir; Baršić, Gorana; Marušić, Katarina; Spalj, Stjepan

    2014-11-01

    To analyze the effect of various coating formulations on the mechanical and corrosion properties of nickel-titanium (NiTi) orthodontic wires. Uncoated, rhodium-coated, and nitrified NiTi wires were observed with a three-point-bend test, surface roughness (Ra) measurement, scanning electron microscopy, energy dispersive spectroscopy, and electrochemical testing (open circuit potential, electrochemical impedance spectroscopy, and cyclic polarization scan). Differences in the properties of tested wire types were analyzed with analysis of variance and Tukey post hoc test. Uncoated and nitrified NiTi wires showed similar mechanical and anticorrosive properties, while rhodium-coated NiTi wires showed the highest Ra and significantly higher modulus of elasticity, yield strength, and delivery of forces during loading but not in unloading. Rhodium-coated NiTi wires also had the highest corrosion current density and corrosion potential, lowest impedance modulus, and two time constants on Bode plot, one related to the Rh/Au coating and the other to underlying NiTi. Working properties of NiTi wires were unaffected by various coatings in unloading. Nitrification improved corrosion resistance. Rhodium coating reduced corrosion resistance and pronounced susceptibility to pitting corrosion in artificial saliva because of galvanic coupling between the noble coating and the base alloy.

  1. Understanding key influencers' attitudes and beliefs about healthy public policy change for obesity prevention.

    Science.gov (United States)

    Raine, Kim D; Nykiforuk, Candace I J; Vu-Nguyen, Karen; Nieuwendyk, Laura M; VanSpronsen, Eric; Reed, Shandy; Wild, T Cameron

    2014-11-01

    As overweight and obesity is a risk factor for chronic diseases, the development of environmental and healthy public policy interventions across multiple sectors has been identified as a key strategy to address this issue. In 2009, a survey was developed to assess the attitudes and beliefs regarding health promotion principles, and the priority and acceptability of policy actions to prevent obesity and chronic diseases, among key policy influencers in Alberta and Manitoba, Canada. Surveys were mailed to 1,765 key influencers from five settings: provincial government, municipal government, school boards, print media companies, and workplaces with greater than 500 employees. A total of 236 surveys were completed with a response rate of 15.0%. Findings indicate nearly unanimous influencer support for individual-focused policy approaches and high support for some environmental policies. Restrictive environmental and economic policies received weakest support. Obesity was comparable to smoking with respect to perceptions as a societal responsibility versus a personal responsibility, boding well for the potential of environmental policy interventions for obesity prevention. This level of influencer support provides a platform for more evidence to be brokered to policy influencers about the effectiveness of environmental policy approaches to obesity prevention. © 2014 The Obesity Society.

  2. Structural properties, electric response and electronic feature of BaSnO{sub 3} perovskite

    Energy Technology Data Exchange (ETDEWEB)

    Cuervo Farfan, J. [Grupo de Fisica de Nuevos Materiales, Departamento de Fisica, Universidad Nacional de Colombia, AA 14490 Bogota D.C. (Colombia); Arbey Rodriguez, J.; Fajardo, F. [Grupo de Estudios de Materiales, Departamento de Fisica, Universidad Nacional de Colombia, Bogota DC (Colombia); Vera Lopez, E. [Grupo de Superficies, Electroquimica y Corrosion, UPTC, Tunja (Colombia); Landinez Tellez, D.A. [Grupo de Fisica de Nuevos Materiales, Departamento de Fisica, Universidad Nacional de Colombia, AA 14490 Bogota D.C. (Colombia); Roa-Rojas, J., E-mail: jroar@unal.edu.c [Grupo de Fisica de Nuevos Materiales, Departamento de Fisica, Universidad Nacional de Colombia, AA 14490 Bogota D.C. (Colombia)

    2009-10-01

    It has been observed that the semiconducting compound SnO{sub 2} presents very good results as gas sensor. One important development has been performed to study perovskite oxides for this relevant application. One oxide material which constitutes an excellent candidate for this technological application is BaSnO{sub 3}. Polycrystalline samples with single phase of BaSnO{sub 3} were synthesized by using the solid state reaction method. Samples were characterized structurally by means of X-ray diffraction (XRD) technique. Rietveld refinement, by using the GSAS code, reveals that this material synthesizes in a cubic perovskite, space group Pm3m (no. 221), with lattice parameter 4.1190(3)A. Electric response was examined through the impedance spectroscopy technique. Results of Bode diagram, from an equivalent circuit, evidence the semiconductor character of material. We carried out a theoretical study by means of the calculation of the bands diagram and the density of states of the BaSnO{sub 3}. Calculation was performed by employing the density functional theory (DFT), with the generalized gradient approach (GGA). DFT theory permitted to establish that BaSnO{sub 3} material has an indirect semiconducting behavior. The calculated gap for this perovskite-like stagnate is at least 0.4 eV. Bulk modulus for material was also determined to be 132 GPa.

  3. A Digitally Controlled Power Converter for an Electrostatic Precipitator

    Directory of Open Access Journals (Sweden)

    Pedro J. Villegas

    2017-12-01

    Full Text Available Electrostatic precipitators (ESPs are devices used in industry to eliminate polluting particles in gases. In order to supply them, an interface must be included between the three-phase main line and the required high DC voltage of tens of kilovolts. This paper describes an 80-kW power supply for such an application. Its structure is based on the series parallel resonant converter with a capacitor as output filter (PRC-LCC, which can adequately cope with the parasitic elements of the step-up transformer involved. The physical implementation of the prototype includes the use of silicon carbide—SiC—semiconductors, which provide better switching capabilities than their traditional silicon—Si—counterparts. As a result, a new control strategy results as a better alternative in which the resonant current is maintained in phase with the first harmonic of the inverter voltage. Although this operation mode imposes hard switching in one of the inverter legs, it minimizes the reactive energy that circulates through the resonant tank, the resonant current amplitude itself and the switching losses. Overall efficiency of the converter benefits from this. These ideas are supported mathematically using the steady state and dynamic models of the topology. They are confirmed with experimental measurements that include waveforms, Bode plots and thermal behavior. The experimental setup delivers 80 kW with an estimated efficiency of 98%.

  4. The Right to Freedom of Expression: The Mother of our Democracy

    Directory of Open Access Journals (Sweden)

    Willem Johannes van Vollenhoven

    2015-12-01

    Full Text Available This paper explores student-teachers' understanding of the right to freedom of expression in education. Analyses of case law and legal principles affirm that the right to freedom of expression is an essential prerequisite to protect and promote democracy. Based on qualitative research, the empirical evidence indicates that although student-teachers are aware of the fact that the right to freedom of expression is not absolute and may be limited, they have a superficial knowledge of the application of this right. Student-teachers have a sense of the importance of the right to freedom of expression in a democracy, but they have not yet internalised the mechanism or process of balancing the right in praxis. This does not bode well as the school system will fail to be a market place of ideas. In order to enable learners to reach their full potential as critical thinkers and autonomous citizens in a developing democracy, it is imperative that teachers should understand and master the application of the right to freedom of expression in schools.

  5. A precise deuterium abundance: remeasurement of the z = 3.572 absorption system towards the quasar PKS1937-101

    Science.gov (United States)

    Riemer-Sørensen, S.; Kotuš, S.; Webb, J. K.; Ali, K.; Dumont, V.; Murphy, M. T.; Carswell, R. F.

    2017-07-01

    The primordial deuterium abundance probes fundamental physics during the big bang nucleosynthesis and can be used to infer cosmological parameters. Observationally, the abundance can be measured using absorbing clouds along the lines of sight to distant quasars. Observations of the quasar PKS1937-101 contain two absorbers for which the deuterium abundance has previously been determined. Here, we focus on the higher redshift one at zabs = 3.572. We present new observations with significantly increased signal-to-noise ratio that enable a far more precise and robust measurement of the deuterium to hydrogen column density ratio, resulting in D I/H I = 2.62 ± 0.05 × 10-5. This particular measurement is of interest because it is amongst the most precise assessments to date and it has been derived from the second lowest column-density absorber [N(H I) = 17.9 cm-2] that has so-far been utilized for deuterium abundance measurements. The majority of existing high-precision measurements were obtained from considerably higher column density systems [I.e. N(H I) > 19.4 cm-2]. This bodes well for future observations as low column density systems are more common.

  6. A boom in energy technology innovation despite decades of stagnant investment

    Energy Technology Data Exchange (ETDEWEB)

    Bettencourt, Luis M [Los Alamos National Laboratory; Trancik, Jessika A [SANTA FE INSTITUTE; Kaur, Jasleen [INDIANA UNIV

    2009-01-01

    Rates of patenting in energy technologies in the United States stagnated during a period of low federal investment in the sector from the mid-1980's through 2000. To analyze the current state of the field, we built a new comprehensive database of energy patents in the USA and worldwide aggregated by nation and technology. We show that innovation in energy technologies, as measured by numbers of new patents, has grown dramatically over the last decade both for renewable and fossil fuel-based technologies, but that traditional investment -government and private support for research and development (R&D) -has not risen commensurately. We also show that while venture capital investment in the sector has increased significantly in the last few years it lags the observed uptick in patenting. We find increasing patenting rates in nations worldwide but also differences in regional priorities, as well as a marked divergence in innovation rates across technologies. Renewable energy technologies - especially solar and wind - currently show the fastest rates of innovation, while patenting levels in nuclear fission have remained low despite relatively high levels of sustained investment. While this sharp increase of innovative activity bodes well for change in the energy sector, the future of emerging technologies may hinge on sustained investment in R&D and favorable incentives for market entry.

  7. Enhancement of osteogenesis on micro/nano-topographical carbon fiber-reinforced polyetheretherketone-nanohydroxyapatite biocomposite.

    Science.gov (United States)

    Xu, Anxiu; Liu, Xiaochen; Gao, Xiang; Deng, Feng; Deng, Yi; Wei, Shicheng

    2015-03-01

    As an FDA-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses excellent mechanical properties similar to those of human cortical bone and is a prime candidate to replace conventional metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. The present work aimed at developing a novel carbon fiber-reinforced polyetheretherketone-nanohydroxyapatite (PEEK/CF/n-HA) ternary biocomposite with micro/nano-topographical surface for the enhancement of the osteogenesis as a potential bioactive material for bone grafting and bone tissue-engineering applications. The combined modification of oxygen plasma and sand-blasting could improve the hydrophily and generate micro/nano-topographical structures on the surface of the CFRPEEK-based ternary biocomposite. The results clearly showcased that the micro-/nano-topographical PEEK/n-HA/CF ternary biocomposite demonstrated the outstanding ability to promote the proliferation and differentiation of MG-63 cells in vitro as well as to boost the osseointegration between implant and bone in vivo, thereby boding well application to bone tissue engineering. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Flow-based impedimetric immunosensor for aflatoxin analysis in milk products.

    Science.gov (United States)

    Kanungo, Lizy; Bacher, Gautam; Bhand, Sunil

    2014-10-01

    Label-free detection technique based on impedance was investigated for aflatoxin M1 (AFM1) and aflatoxin M2 (AFM2) analysis in milk products. The impedance change resulting from antigen-antibody interaction was studied using a two-electrode setup made up of silver (Ag) wire. Processed milk such as drinking yogurt and flavored milk samples were analyzed in a flow-based setup. Two microflow pumps were used to construct the flow system where analytes (AFM1 and AFM2) were injected and impedance was measured using functionalized Ag wire electrodes. The flow system was optimized by adjusting both inlet and outlet flows to maintain the reaction volume optimum for impedance measurements. Using Bode plot, the matrix effect was investigated for detection of AFM1 and AFM2 in various matrices. Good recoveries were obtained even at low-AFM1 concentrations in the range of 1-100 pg/mL. The influence of AFM2 on the detection of AFM1 was also investigated. The proposed method provides good scope for online monitoring of such hazardous toxins in milk products.

  9. Identification method for helicopter flight dynamics modeling with rotor degrees of freedom

    Directory of Open Access Journals (Sweden)

    Wu Wei

    2014-12-01

    Full Text Available A comprehensive method based on system identification theory for helicopter flight dynamics modeling with rotor degrees of freedom is developed. A fully parameterized rotor flapping equation for identification purpose is derived without using any theoretical model, so the confidence of the identified model is increased, and then the 6 degrees of freedom rigid body model is extended to 9 degrees of freedom high-order model. Bode sensitivity function is derived to increase the accuracy of frequency spectra calculation which influences the accuracy of model parameter identification. Then a frequency domain identification algorithm is established. Acceleration technique is developed furthermore to increase calculation efficiency, and the total identification time is reduced by more than 50% using this technique. A comprehensive two-step method is established for helicopter high-order flight dynamics model identification which increases the numerical stability of model identification compared with single step algorithm. Application of the developed method to identify the flight dynamics model of BO 105 helicopter based on flight test data is implemented. A comparative study between the high-order model and rigid body model is performed at last. The results show that the developed method can be used for helicopter high-order flight dynamics model identification with high accuracy as well as efficiency, and the advantage of identified high-order model is very obvious compared with low-order model.

  10. Long-term antibacterial characteristics and cytocompatibility of titania nanotubes loaded with Au nanoparticles without photocatalytic effects

    Science.gov (United States)

    Wang, Guomin; Feng, Hongqing; Jin, Weihong; Gao, Ang; Peng, Xiang; Li, Wan; Wu, Hao; Li, Zhou; Chu, Paul K.

    2017-08-01

    Au nanoparticles (NPs) can endow titania nanotubes (Au@TiO2-NT) with light-independent antibacterial properties which bode well for in vivo application because of the dark environment inside tissues. In this work, the long-term antibacterial bactericidal properties and cytocompatibility of Au@TiO2-NT without photocatalytic effects are studied in details. The materials exhibit antibacterial effects against Staphylococcus aureus according to antibacterial tests carried out for a total time of 21 days, which are normally long enough for early stage tissue healing after surgery. In addition, adhesion and proliferation of MC3T3-E1 osteoblasts on Au@TiO2-NT reveal cytocompatibility comparable to that of TiO2-NT. No reactive oxygen species (ROS) are detected from either the bacteria or MC3T3-E1 cells cultured on the Au@TiO2-NT surface. The absence of ROS, long-term antibacterial properties, and cytocompatibility make Au@TiO2-NT promising biomaterials in orthopedic devices and implants.

  11. LHC Report: A new luminosity record

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    After about one month of operation, the LHC has already accumulated an integrated luminosity of 28 pb-1, which corresponds to over 50% of the total delivered to the experiments in 2010. This impressive start to the LHC run in 2011 bodes well for the rest of year.   Following careful collimator set-up and validation, the first phase of beam commissioning 2011 has come to an end. The first stable beams were declared on Sunday 13 March with a moderate 3 bunches per beam and an initial luminosity of 1.6 × 1030 cm-2s-1. Machine protection tests continued during the following week as the commissioning team made absolutely sure that all critical systems (beam dumps, beam interlock system, etc.) were functioning properly. When these tests had finished, the way was opened to increased intensity and the LHC quickly moved through the first part of its planned, staged intensity increase. Fills with increasing numbers of bunches were delivered to the experiments, culminating in a fill with 200...

  12. Genetic structure of herpetofauna on Halmahera Island, Indonesia: implications for Aketajawe-Lolobata National Park.

    Science.gov (United States)

    Setiadi, Mohammad Iqbal; Hamidy, Amir; Abidin, Zainal; Susanto, Dwi; Brown, Rafe M; Peterson, A Townsend; Li, Xingong; Evans, Ben J

    2010-04-01

    Genetic variation within species--a priority for biodiversity conservation--is influenced by natural selection, demography, and stochastic events such as genetic drift. We evaluated the role of these factors in 14 codistributed species of reptiles and amphibians on the Indonesian island of Halmahera by testing whether their molecular variation was correlated with geographic distance, ecology, riverine barriers, or Halmahera's paleoisland precursors. We found support for isolation by distance effects in four species. Two of these four were also significantly affected either by rivers or by ecology. A fifth species was significantly affected by ecology and a sixth was significantly affected by Halmahera's paleoislands. These findings--the most comprehensive survey of multispecies genetic variation on Halmahera to date--bode well for the efficacy of the recently established Aketajawe-Lolobata National Park in conserving a substantial component of vertebrate genetic variation on this island. Future success of conservation efforts will depend crucially, of course, on funding for and enforcement of conservation management of this park.

  13. Technocultural education

    Directory of Open Access Journals (Sweden)

    Lars Løvlie

    2006-03-01

    Full Text Available In this essay I try to describe the development of a traditional liberal education into a technological liberal one. I propose that we start by dropping the classical oppositions between man and animal, and man and machine; that we stop pitting morality against technology and rhetoric; and that we do away with the idea that ICT in our schools will necessarily tear the fabric of education apart. We should rather try and re-describe the idea of an unencumbered and independent self in terms of relational concepts, like the cyborg or more radically: like the self as interface. John Dewey led the way to this view a century ago, by coining the word intelligence as the name of educative interactions between man, animal and machine. The self as interface is a self of differences rather than identities. But that idea does not do away with our emplaced body, or our personal sense of self and identity. In the postmodern world, the cyborg is a migrant with the ability to interpret signs, understand symbols of power, see through rhetorical games, engage in argumentation, and in these activities partake in his or her own political education. The Internet nomad does not bode anarchy. He or she is the radically decentred subject that may well participate in Kant’s cosmopolitanism, Jürgen Habermas’ discourse ethics and Jacques Derrida’s deconstruction. – But this is to go slightly beyond the text submitted here …

  14. Comparison of recording positions of physical activity in patients with severe COPD undergoing LTOT.

    Science.gov (United States)

    Gorzelniak, Lukas; Dias, André; Schultz, Konrad; Wittmann, Michael; Karrasch, Stefan; Jörres, Rudolf A; Horsch, Alexander

    2012-08-01

    Accelerometry is increasingly used to assess physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD). It is not known how the relationship of PA to clinical results depends on the position of the PA sensor. We assessed the effect of monitor position by measuring lower extremity (ankle), upper extremity (wrist) and total body movement (hip) in 52 patients with severe COPD (mean [± SD] age, 62 ± 10 years; FEV(1), 38 ± 12% predicted) undergoing long-term oxygen therapy with and without walkers during a pulmonary rehabilitation (PR) program. Sensors were worn 8.5 ± 3.1 days and data was compared to the BODE score and the 6-minute walk distance (6MWD) assessed at the beginning and end of the PR. Mean ankle PA was moderately related to the 6MWD, irrespective of patients being equipped with a walker or not (p impact on the association between PA recordings and the 6MWD in very severe COPD. In our setting, ankle measurement seemed to best reflect the clinical state of patients.

  15. Experimental Characterization of Ionic Polymer Metal Composite as a Novel Fractional Order Element

    Directory of Open Access Journals (Sweden)

    Riccardo Caponetto

    2013-01-01

    Full Text Available Ionic polymer metal composites (IPMCs are electroactive materials made of ionic polymer thin membranes with platinum metallization on their surfaces. They are interesting materials due to not only their electromechanical applications as transducers but also to their electrochemical features and the relationship between the ionic/solvent current and the potential field. Their electrochemical properties thus suggest the possibility for exploiting them as compact fractional-order elements (FOEs with a view of defining fabrication processes and production strategies that assure the desired performances. In this paper, the experimental electrical characterization of a brand new IPMC setup in a fixed sandwich configuration is proposed. Two IPMC devices with different platinum absorption times (5 h and 20 h are characterized through experimental data: first, a preliminary linearity study is performed for a fixed input voltage amplitude in order to determine the frequency region where IPMC can be approximated as linear; then, a frequency analysis is carried out in order to identify a coherent fractional-order dynamics in the bode diagrams. Such analyses take the first steps towards a simplified model of IPMC as a compact electronic FOE for which the fractional exponent value depends on fabrication parameters as the absorption time.

  16. Estimating the spin diffusion length and the spin Hall angle from spin pumping induced inverse spin Hall voltages

    Science.gov (United States)

    Roy, Kuntal

    2017-11-01

    There exists considerable confusion in estimating the spin diffusion length of materials with high spin-orbit coupling from spin pumping experiments. For designing functional devices, it is important to determine the spin diffusion length with sufficient accuracy from experimental results. An inaccurate estimation of spin diffusion length also affects the estimation of other parameters (e.g., spin mixing conductance, spin Hall angle) concomitantly. The spin diffusion length for platinum (Pt) has been reported in the literature in a wide range of 0.5-14 nm, and in particular it is a constant value independent of Pt's thickness. Here, the key reasonings behind such a wide range of reported values of spin diffusion length have been identified comprehensively. In particular, it is shown here that a thickness-dependent conductivity and spin diffusion length is necessary to simultaneously match the experimental results of effective spin mixing conductance and inverse spin Hall voltage due to spin pumping. Such a thickness-dependent spin diffusion length is tantamount to the Elliott-Yafet spin relaxation mechanism, which bodes well for transitional metals. This conclusion is not altered even when there is significant interfacial spin memory loss. Furthermore, the variations in the estimated parameters are also studied, which is important for technological applications.

  17. Facile Fabrication of MoS2-Modified SnO2 Hybrid Nanocomposite for Ultrasensitive Humidity Sensing.

    Science.gov (United States)

    Zhang, Dongzhi; Sun, Yan'e; Li, Peng; Zhang, Yong

    2016-06-08

    An ultrasensitive humidity sensor based on molybdenum-disulfide- (MoS2)-modified tin oxide (SnO2) nanocomposite has been demonstrated in this work. The nanostructural, morphological, and compositional properties of an as-prepared MoS2/SnO2 nanocomposite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive spectrometry (EDS), nitrogen sorption analysis, and Raman spectroscopy, which confirmed its successful preparation and rationality. The sensing characteristics of the MoS2/SnO2 hybrid film device against relative humidity (RH) were investigated at room temperature. The RH sensing results revealed an unprecedented response, ultrafast response/recovery behaviors, and outstanding repeatability. To our knowledge, the sensor response yielded in this work was tens of times higher than that of the existing humidity sensors. Moreover, the MoS2/SnO2 hybrid nanocomposite film sensor exhibited great enhancement in humidity sensing performances as compared to the pure MoS2, SnO2, and graphene counterparts. Furthermore, complex impedance spectroscopy and bode plots were employed to understand the underlying sensing mechanisms of the MoS2/SnO2 nanocomposite toward humidity. The synthesized MoS2/SnO2 hybrid composite was proved to be an excellent candidate for constructing ultrahigh-performance humidity sensor toward various applications.

  18. Synthesis of mesoporous niobium nitride nanobelt arrays and their capacitive properties

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Biao; Xiao, Xiang; Su, Jianjun [The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081 (China); Zhang, Xuming, E-mail: xumzhang@wust.edu.cn [The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081 (China); Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China); Peng, Xiang [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China); Fu, Jijiang, E-mail: fujijiang@wust.edu.cn [The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081 (China); Chu, Paul K. [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China)

    2016-10-15

    Highlights: • Nb{sub 4}N{sub 5} NBAs was fabricated by hydrothermal reaction, protonation and nitridation. • The Nb foil provides the source of Nb and works as the conductive substrate. • Nb{sub 4}N{sub 5} NBAs electrode delivers good specific capacitance and rate performance. • The good capacitive property is attributable to high porosity and conductivity. - Abstract: Mesoporous niobium nitride nanobelt arrays (Nb{sub 4}N{sub 5} NBAs) are fabricated directly on Nb foils by a hydrothermal reaction in KOH, protonation treatment in HNO{sub 3}, and calcination in an NH{sub 3} ambient. The morphology, composition and pore structure of the Nb{sub 4}N{sub 5} NBAs are characterized in details. In addition, the mesoporous Nb{sub 4}N{sub 5} NBAs electrode has good specific capacitance (37.4 mF cm{sup −2}, or 124 F g{sup −1}) and delivers excellent rate performance due to the high porosity and good electron conductivity boding well for application to next-generation energy storage systems.

  19. Research of Active Power Filter Modeling with Grid Impedance in Feedback Linearization and Quasi-Sliding Mode Control

    Directory of Open Access Journals (Sweden)

    Zeyu Shi

    2017-01-01

    Full Text Available Active power filter (APF is the most popular device in regulating power quality issues. Currently, most literatures ignored the impact of grid impedance and assumed the load voltage is ideal, which had not described the system accurately. In addition, the controllers applied PI control; thus it is hard to improve the compensation quality. This paper establishes a precise model which consists of APF, load, and grid impedance. The Bode diagram of traditional simplified model is obviously different with complete model, which means the descriptions of the system based on the traditional simplified model are inaccurate and incomplete. And then design exact feedback linearization and quasi-sliding mode control (FBL-QSMC is based on precise model in inner current loop. The system performances in different parameters are analyzed and dynamic performance of proposed algorithm is compared with traditional PI control algorithm. At last, simulations are taken in three cases to verify the performance of proposed control algorithm. The results proved that the proposed feedback linearization and quasi-sliding mode control algorithm has fast response and robustness; the compensation performance is superior to PI control obviously, which also means the complete modeling and proposed control algorithm are correct.

  20. Meeting at the crossroads: collaboration between information technology departments and health sciences libraries.

    Science.gov (United States)

    King, Samuel; Cataldi-Roberts, Erica; Wentz, Erin

    2017-01-01

    The purposes of this survey were to determine the nature and extent of collaboration between health sciences libraries and their information technology (IT) departments, to identify strengths and issues connected to this relationship, and to provide examples demonstrating exceptional collaborative success. A fourteen-question survey was sent to a broad selection of health care and academic libraries through a variety of email discussion lists and was limited to one response per institution. Convenience sampling was used to collect the responses. An overwhelming majority of libraries described the relationship with their IT departments as good or excellent, and there were a variety of creative joint initiatives underway. Opportunities exist for continued and expanded library/IT collaboration. Good quality relationships between libraries and their IT departments are essential due to the interconnected nature of their services, and fortunately, this appears to be the norm at a variety of institutions. Mutual respect, open communication, realization of each department's mission, and responsiveness to each other's needs are part of what makes these relationships successful, which in turn leads to successful collaborative ventures that bode well for the future of both services.

  1. Joint trajectories for social and physical aggression as predictors of adolescent maladjustment: internalizing symptoms, rule-breaking behaviors, and borderline and narcissistic personality features.

    Science.gov (United States)

    Underwood, Marion K; Beron, Kurt J; Rosen, Lisa H

    2011-05-01

    This investigation examined the relation between developmental trajectories jointly estimated for social and physical aggression and adjustment problems at age 14. Teachers provided ratings of children's social and physical aggression in Grades 3, 4, 5, 6, and 7 for a sample of 255 children (131 girls, 21% African American, 52% European American, 21% Mexican American). Participants, parents, and teachers completed measures of the adolescent's adjustment to assess internalizing symptoms, rule-breaking behaviors, and borderline and narcissistic personality features. Results showed that membership in a high and rising trajectory group predicted rule-breaking behaviors and borderline personality features. Membership in a high desister group predicted internalizing symptoms, rule-breaking behaviors, and borderline and narcissistic personality features. The findings suggest that although low levels of social and physical aggression may not bode poorly for adjustment, individuals engaging in high levels of social and physical aggression in middle childhood may be at greatest risk for adolescent psychopathology, whether they increase or desist in their aggression through early adolescence.

  2. Reduction of Hexavalent Chromium Using Sorbaria sorbifolia Aqueous Leaf Extract

    Directory of Open Access Journals (Sweden)

    Shashi Prabha Dubey

    2017-07-01

    Full Text Available Aqueous plant leaves extract (PLE of an abundant shrub, Sorbaria sorbifolia, was explored for the reduction of hexavalent chromium, Cr(VI, to trivalent chromium, Cr(III. The effect of contact time, pH, PLE quantity, ionic strength, hardness, temperature and effective initial Cr(VI ion concentration were tested; Cr(VI reduction followed the pseudo-first order rate kinetics and maximum reduction was observed at pH 2. Significantly, Cr(VI reduction efficacies varied from 97 to 66% over the pH range of 2 to 10, which bodes well for PLE to be used for the reduction of Cr(VI also at a higher pH. PLE-mediated Cr(VI reduction displays considerable efficiency at various ionic strengths; however, hardness strongly affects the reduction ability. Higher temperature significantly enhances the Cr(VI reduction. This study reveals the potential use of PLE as a green reducing agent in aqueous extract for the efficient reduction of Cr(VI to Cr(III.

  3. Early investigations of Ceres and the discovery of Pallas historical studies in asteroid research

    CERN Document Server

    Cunningham, Clifford

    2016-01-01

    An asteroid scholar, Cunningham in this book picks up where his Discovery of the First Asteroid, Ceres left off in telling the story of the impact created by the discovery of this new class of object in the early 1800s. The best and brightest minds of mathematics, science, and philosophy were fascinated by Ceres, and figures as diverse as Gauss, Herschel, Brougham, Kant, and Laplace all contributed something to the conversation. The first few chapters deal with the mathematical and philosophical aspects of the discovery, and the rivalry between Germany and France that so affected science and astronomy of that era. The jockeying for glory over the discovery of Ceres by both Piazzi and Bode is examined in detail, as is the reception given to Herschel’s use of the word 'asteroid.' Archival research that reveals the creator of the word 'asteroid' is presented in this book. Astronomy was a truly cosmopolitan field at the time, spanning across various disciplines, and the discovery of Pallas, a story completely t...

  4. Discharge Driven Nitrogen Dynamics in a Mesoscale River Basin As Constrained by Stable Isotope Patterns.

    Science.gov (United States)

    Mueller, Christin; Zink, Matthias; Samaniego, Luis; Krieg, Ronald; Merz, Ralf; Rode, Michael; Knöller, Kay

    2016-09-06

    Nitrate loads and corresponding dual-isotope signatures were used to evaluate large scale N dynamics and trends in a river catchment with a strong anthropogenic gradient (forest conservation areas in mountain regions, and intensive agriculturally used lowlands). The Bode River catchment with an area of 3200 km(2) in the Harz Mountains and central German lowlands was investigated by a two years monitoring program including 133 water sampling points each representing a subcatchment. Based on discharge data either observed or simulated by the mesoscale hydrological model (mHM) a load based interpretation of hydrochemical and isotope data was conducted. Nitrate isotopic signatures in the entire catchment are influenced by (I) the contribution of different nitrogen sources, (II) by variable environmental conditions during the formation of nitrate, and (III) by a minor impact of denitrification. For major tributaries, a relationship between discharge and nitrate isotopic signatures is observed. This may in part be due to the fact, that during periods of higher hydrologic activity a higher wash out of isotopically lighter nitrate formed by bacterial nitrification processes of reduced or organic soil nitrogen occurs. Beyond that, in-stream denitrification seems to be more intense during periods of low flow.

  5. High genetic diversity and low population structure in Porter's sunflower (Helianthus porteri).

    Science.gov (United States)

    Gevaert, Scott D; Mandel, Jennifer R; Burke, John M; Donovan, Lisa A

    2013-01-01

    Granite outcrops in the southeastern United States are rare and isolated habitats that support edaphically controlled communities dominated by herbaceous plants. They harbor rare and endemic species that are expected to have low genetic variability and high population structure due to small population sizes and their disjunct habitat. We test this expectation for an annual outcrop endemic, Helianthus porteri (Porter's sunflower). Contrary to expectation, H. porteri has relatively high genetic diversity (H e = 0.681) and relatively low genetic structure among the native populations (F ST = 0.077) when compared to 5 other Helianthus species (N = 288; 18 expressed sequence tag-SSR markers). These findings suggest greater gene flow than expected. The potential for gene flow is supported by the analysis of transplant populations established with propagules from a common source in 1959. One population established close to a native population (1.5 km) at the edge of the natural range is genetically similar to and shares rare alleles with the adjacent native population and is distinct from the central source population. In contrast, a transplant population established north of the native range has remained similar to the source population. The relatively high genetic diversity and low population structure of this species, combined with the long-term success of transplanted populations, bode well for its persistence as long as the habitat persists.

  6. INCA- INTERACTIVE CONTROLS ANALYSIS

    Science.gov (United States)

    Bauer, F. H.

    1994-01-01

    plane to W plane and back. These capabilities allow the INCA user to perform block diagram algebraic manipulations quickly for functions in the S, Z, and W domains. Additionally, a versatile digital control capability has been included in INCA. Special plane transformations allow the user to easily convert functions from one domain to another. Other digital control capabilities include: 1) totally independent open loop frequency response analyses on a continuous plant, discrete control system with a delay, 2) advanced Z-transform capability for systems with delays, and 3) multirate sampling analyses. The current version of INCA includes Dynamic Functions (which change when a parameter changes), standard filter generation, PD and PID controller generation, incorporation of the QZ-algorithm (function addition, inverse Laplace), and describing functions that allow the user to calculate the gain and phase characteristics of a nonlinear device. The INCA graphic modes provide the user with a convenient means to document and study frequency response, time response, and root locus analyses. General graphics features include: 1) zooming and dezooming, 2) plot documentation, 3) a table of analytic computation results, 4) multiple curves on the same plot, and 5) displaying frequency and gain information for a specific point on a curve. Additional capabilities in the frequency response mode include: 1) a full complement of graphical methods Bode magnitude, Bode phase, Bode combined magnitude and phase, Bode strip plots, root contour plots, Nyquist, Nichols, and Popov plots; 2) user selected plot scaling; and 3) gain and phase margin calculation and display. In the time response mode, additional capabilities include: 1) support for inverse Laplace and inverse Z transforms, 2) support for various input functions, 3) closed loop response evaluation, 4) loop gain sensitivity analyses, 5) intersample time response for discrete systems using the advanced Z transform, and 6) closed loop

  7. Health rights in the balance: the case against perinatal shackling of women behind bars.

    Science.gov (United States)

    Dignam, Brett; Adashi, Eli Y

    2014-12-11

    Rationalized for decades on security grounds, perinatal shackling entails the application of handcuffs, leg irons, and/or waist shackles to the incarcerated woman prior to, during, and after labor and delivery. During labor and delivery proper, perinatal shackling may entail chaining women to the hospital bed by the ankle, wrist, or both. Medically untenable, legally challenged, and ever controversial, perinatal shackling remains the standard of practice in most US states despite sustained two-decades-long efforts by health rights legal advocates, human rights organizations, and medical professionals. Herein we review the current statutory, regulatory, legal, and medical framework undergirding the use of restraints on pregnant inmates and explore potential avenues of redress and relief to this challenge. We also recognize the courage of the women whose stories are being told. If history is any guide, the collective thrust of domestic and international law, attendant litigation, dedicated advocacy, and strength of argument bode well for continued progress toward restraint-free pregnancies in correctional settings. Copyright © 2014 Dignam and Adashi. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  8. Genetic Pedigree Analysis of the Pilot Breeding Program for the Rediscovered Galapagos Giant Tortoise from Floreana Island.

    Science.gov (United States)

    Miller, Joshua M; Quinzin, Maud C; Scheibe, Elizabeth H; Ciofi, Claudio; Villalva, Fredy; Tapia, Washington; Caccone, Adalgisa

    2018-02-27

    An aim of many captive breeding programs is to increase population sizes for reintroduction and establishment of self-sustaining wild populations. Genetic analyses play a critical role in these programs: monitoring genetic variation, identifying the origin of individuals, and assigning parentage to track family sizes. Here we use genetic pedigree analyses to examine three seasons of a pilot breeding program for the Floreana island Galapagos giant tortoise, C. niger, that had been declared extinct for ~150 years until individuals with mixed ancestry were recently discovered. We determined that eight of nine founding individuals were assigned parentage to at least one of 130 offspring produced, though there was considerable reproductive skew. In addition, we observed that genetic diversity of the progeny was lower than that of the founders. Despite the observed reproductive skew, we did not see evidence for assortative mating based on relatedness, but there was a trend towards reduced fitness when more related individuals bred. Finally, we found that the majority of progeny had ancestry assigned to the Floreana species (mean±SE = 0.51±0.02), though individual estimates varied. The success of these pilot seasons bodes well for a larger breeding program to help restore the previously extinct tortoise from Floreana island. Future efforts should continue to monitor for reproductive skew and assortative mating in order to maintain allelic diversity. We would also recommend forming smaller breeding groups and rotating individuals among them to prevent long-term reproductive skew among pairs.

  9. Relación entre la creación de valor y la inversión en I+D: una aproximación mediante redes neuronales artificiales

    Directory of Open Access Journals (Sweden)

    Ángel Samaniego Alcántar

    2013-11-01

    Full Text Available Este documento proporciona nueva evidencia sobre la interacción de los efectos del tipo de interés a cinco años, el nivel de apalancamiento (la relación del pasivo y activo, las pérdidas históricas, el crecimiento del PIB, la intensidad del gasto en I+D y los ingresos con el rendimiento de la acción en el corto plazo. El modelo no lineal utilizado (combinación de modelos mediante redes neuronales artificiales explica 31.59% de la varianza del rendimiento de las acciones en los primeros 5 meses del año, entre 2000-2006, en los mercados AMEX, NASDAQ y NYSE. Existe evidencia en la literatura que el 32% de explicación es alto, en comparación al estudio de la literatura realizado por Coad (2009 donde se utilizan modelos lineales que buscan explicar el crecimiento de la empresa. Se observa que los modelos lineales explican entre el 17% al 32% de la variabilidad de los datos. Al igual que en los trabajos de Bode (1998, Tsai (2005, Wang y Chien (2006 y Chien et al. (2010 se utilizan las redes neuronales artificiales para el estudio de la interacción entre la I+D y la empresa.

  10. Drought-induced starvation of aardvarks in the Kalahari: an indirect effect of climate change.

    Science.gov (United States)

    Rey, Benjamin; Fuller, Andrea; Mitchell, Duncan; Meyer, Leith C R; Hetem, Robyn S

    2017-07-01

    Aardvarks (Orycteropus afer) are elusive burrowing mammals, predominantly nocturnal and distributed widely throughout Africa except for arid deserts. Their survival may be threatened by climate change via direct and indirect effects of increasing heat and aridity. To measure their current physiological plasticity, we implanted biologgers into six adult aardvarks resident in the semi-arid Kalahari. Following a particularly dry and hot summer, five of the study aardvarks and 11 other aardvarks at the study site died. Body temperature records revealed homeothermy (35.4-37.2°C) initially, but heterothermy increased progressively through the summer, with declining troughs in the nychthemeral rhythm of body temperature reaching as low as 25°C before death, likely due to starvation. Activity patterns shifted from the normal nocturnal to a diurnal mode. Our results do not bode well for the future of aardvarks facing climate change. Extirpation of aardvarks, which play a key role as ecosystem engineers, may disrupt stability of African ecosystems. © 2017 The Author(s).

  11. Mylodon darwinii DNA sequences from ancient fecal hair shafts.

    Science.gov (United States)

    Clack, Andrew A; MacPhee, Ross D E; Poinar, Hendrik N

    2012-01-20

    Preserved hair has been increasingly used as an ancient DNA source in high throughput sequencing endeavors, and it may actually offer several advantages compared to more traditional ancient DNA substrates like bone. However, cold environments have yielded the most informative ancient hair specimens, while its preservation, and thus utility, in temperate regions is not well documented. Coprolites could represent a previously underutilized preservation substrate for hairs, which, if present therein, represent macroscopic packages of specific cells that are relatively simple to separate, clean and process. In this pilot study, we report amplicons 147-152 base pairs in length (w/primers) from hair shafts preserved in a south Chilean coprolite attributed to Darwin's extinct ground sloth, Mylodon darwinii. Our results suggest that hairs preserved in coprolites from temperate cave environments can serve as an effective source of ancient DNA. This bodes well for potential molecular-based population and phylogeographic studies on sloths, several species of which have been understudied despite leaving numerous coprolites in caves across of the Americas. Copyright © 2011. Published by Elsevier GmbH.

  12. Design, analysis and control of large transports so that control of engine thrust can be used as a back-up of the primary flight controls. Ph.D. Thesis

    Science.gov (United States)

    Roskam, Jan; Ackers, Deane E.; Gerren, Donna S.

    1995-01-01

    A propulsion controlled aircraft (PCA) system has been developed at NASA Dryden Flight Research Center at Edwards Air Force Base, California, to provide safe, emergency landing capability should the primary flight control system of the aircraft fail. As a result of the successful PCA work being done at NASA Dryden, this project investigated the possibility of incorporating the PCA system as a backup flight control system in the design of a large, ultra-high capacity megatransport in such a way that flight path control using only the engines is not only possible, but meets MIL-Spec Level 1 or Level 2 handling quality requirements. An 800 passenger megatransport aircraft was designed and programmed into the NASA Dryden simulator. Many different analysis methods were used to evaluate the flying qualities of the megatransport while using engine thrust for flight path control, including: (1) Bode and root locus plot analysis to evaluate the frequency and damping ratio response of the megatransport; (2) analysis of actual simulator strip chart recordings to evaluate the time history response of the megatransport; and (3) analysis of Cooper-Harper pilot ratings by two NaSA test pilots.

  13. Practical guidance for using rivaroxaban in patients with atrial fibrillation: balancing benefit and risk

    Directory of Open Access Journals (Sweden)

    Haas S

    2014-03-01

    Full Text Available Sylvia Haas,1 Christoph Bode,2 Bo Norrving,3 Alexander GG Turpie4 1Technical University Munich, Munich, Germany; 2Department of Cardiology and Angiology, University of Freiburg, Freiburg, Germany; 3Department of Clinical Neuroscience, Lund University Hospital, Lund, Sweden; 4Department of Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Rivaroxaban is a direct factor Xa inhibitor that is widely available to reduce the risk of stroke or systemic embolism in patients with nonvalvular atrial fibrillation and one or more risk factors for stroke. Rivaroxaban provides practical advantages compared with warfarin and other vitamin K antagonists, including a rapid onset of action, few drug interactions, no dietary interactions, a predictable anticoagulant effect, and no requirement for routine coagulation monitoring. However, questions have emerged relating to the responsible use of rivaroxaban in day-to-day clinical practice, including patient selection, dosing, treatment of patients with renal impairment, conversion from use of vitamin K antagonists to rivaroxaban and vice versa, coagulation tests, and management of patients requiring invasive procedures or experiencing bleeding or an ischemic event. This article provides practical recommendations relating to the use of rivaroxaban in patients with nonvalvular atrial fibrillation, based on clinical trial evidence, relevant guidelines, prescribing information, and the authors' clinical experience. Keywords: novel oral anticoagulants, direct factor Xa inhibitor, peri-interventional management, practical guidance, rivaroxaban, stroke prevention

  14. Enhancement of osteogenesis on micro/nano-topographical carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite biocomposite

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Anxiu [College of Stomatology, Chongqing Medical University, Chongqing 401147 (China); Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147 (China); Liu, Xiaochen [Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871 (China); Gao, Xiang; Deng, Feng [College of Stomatology, Chongqing Medical University, Chongqing 401147 (China); Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147 (China); Deng, Yi, E-mail: 18210357357@163.com [College of Stomatology, Chongqing Medical University, Chongqing 401147 (China); Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147 (China); Wei, Shicheng, E-mail: weishicheng99@163.com [College of Stomatology, Chongqing Medical University, Chongqing 401147 (China); Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147 (China)

    2015-03-01

    As an FDA-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses excellent mechanical properties similar to those of human cortical bone and is a prime candidate to replace conventional metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. The present work aimed at developing a novel carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite (PEEK/CF/n-HA) ternary biocomposite with micro/nano-topographical surface for the enhancement of the osteogenesis as a potential bioactive material for bone grafting and bone tissue-engineering applications. The combined modification of oxygen plasma and sand-blasting could improve the hydrophily and generate micro/nano-topographical structures on the surface of the CFRPEEK-based ternary biocomposite. The results clearly showcased that the micro-/nano-topographical PEEK/n-HA/CF ternary biocomposite demonstrated the outstanding ability to promote the proliferation and differentiation of MG-63 cells in vitro as well as to boost the osseointegration between implant and bone in vivo, thereby boding well application to bone tissue engineering. - Highlights: • A novel micro/nano-topographical PEEK/n-HA/CF ternary biocomposite was developed. • The modified PEEK biocomposite promotes proliferation and differentiation of cells. • In vivo osseointegration of the micro/nano-topographical PEEK/n-HA/CF was enhanced.

  15. Urate-lowering therapy: current options and future prospects for elderly patients with gout.

    Science.gov (United States)

    Stamp, Lisa K; Chapman, Peter T

    2014-11-01

    Gout is increasingly seen in the elderly population, in large part due to physiological decline in renal function with age, and as a result of therapy for comorbidities, in particular the use of diuretic therapies for hypertension and congestive heart failure. Urate-lowering therapy (ULT) is the cornerstone of successful long-term gout management with the aim of achieving a sustained reduction in urate (gout, the last 5-10 years has seen a plethora of new agents with several now used in routine clinical practice. There has also been a renewed focus on the optimal use of established ULT, specifically allopurinol, which remains the first-line therapy for most patients. There is emerging data on its use in patients with renal impairment and better recognition of risk factors of the rare but potentially lethal allopurinol hypersensitivity syndrome (AHS). Febuxostat, a new xanthine oxidase inhibitor, is now established in everyday practice. Uricosuric agents may be indicated in certain patient groups, whilst a new class of recombinant uricases (pegloticase) given by intravenous infusion may achieve dramatic and rapid urate-lowering effects. Cost and other factors have thus far limited its use to the very severe cases. Furthermore, increased understanding of urate metabolism has led to the development of a number of drugs currently under clinical evaluation. Common therapeutic targets are the urate transporters in the kidney and alternative xanthine oxidase inhibition pathways. These advances bode well for the better management of gout and hyperuricaemia in our elderly patients.

  16. Nucleosynthesis Predictions and High-Precision Deuterium Measurements

    Directory of Open Access Journals (Sweden)

    Signe Riemer-Sørensen

    2017-05-01

    Full Text Available Two new high-precision measurements of the deuterium abundance from absorbers along the line of sight to the quasar PKS1937–1009 were presented. The absorbers have lower neutral hydrogen column densities (N(HI ≈ 18 cm − 2 than for previous high-precision measurements, boding well for further extensions of the sample due to the plenitude of low column density absorbers. The total high-precision sample now consists of 12 measurements with a weighted average deuterium abundance of D/H = 2 . 55 ± 0 . 02 × 10 − 5 . The sample does not favour a dipole similar to the one detected for the fine structure constant. The increased precision also calls for improved nucleosynthesis predictions. For that purpose we have updated the public AlterBBN code including new reactions, updated nuclear reaction rates, and the possibility of adding new physics such as dark matter. The standard Big Bang Nucleosynthesis prediction of D/H = 2 . 456 ± 0 . 057 × 10 − 5 is consistent with the observed value within 1.7 standard deviations.

  17. Bode’s law and the discovery of Juno historical studies in asteroid research

    CERN Document Server

    Cunningham, Clifford J

    2017-01-01

    Johann Bode developed a so-called law of planetary distances best known as Bode’s Law. The story of the discovery of Juno in 1804 by Karl Harding tells how Juno fit into that scheme and is examined as it relates to the philosopher Georg Hegel’s 1801 thesis that there could be no planets between Mars and Jupiter. By 1804 that gap was not only filled but had three residents: Ceres, Pallas and Juno! When Juno was discovered no one could have imagined its study would call into question Newton’s law of gravity, or be the impetus for developing the mathematics of the fast Fourier transform by Carl Gauss. Clifford Cunningham, a dedicated scholar, opens to scrutiny this critical moment of astronomical discovery, continuing the story of asteroid begun in earlier volumes of this series. The fascinating issues raised by the discovery of Juno take us on an extraordinary journey. The revelation of the existence of this new class of celestial bodies transformed our understanding of the Solar System, the implications ...

  18. Solution-processed inorganic copper(I) thiocyanate (CuSCN) hole transporting layers for efficient p–i–n perovskite solar cells

    KAUST Repository

    Zhao, Kui

    2015-08-27

    CuSCN is a highly transparent, highly stable, low cost and easy to solution process HTL that is proposed as a low cost replacement to existing organic and inorganic metal oxide hole transporting materials. Here, we demonstrate hybrid organic-inorganic perovskite-based p-i-n planar heterojunction solar cells using a solution-processed copper(I) thiocyanate (CuSCN) bottom hole transporting layer (HTL). CuSCN, with its high workfunction, increases the open circuit voltage (Voc) by 0.23 V to 1.06 V as compared with devices based on the well-known poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) (0.83 V), resulting in a superior power conversion efficiency (PCE) of 10.8% without any notable hysteresis. Photoluminescence measurements suggest a similar efficiency of charge transfer at HTL/perovskite interface as PEDOT:PSS. However, we observe more efficient light harvesting in the presence of CuSCN at shorter wavelengths despite PEDOT:PSS being more transparent. Further investigation of the microstructure and morphology reveals differences in the crystallographic texture of the polycrystalline perovskite film, suggesting somewhat modified perovskite growth on the surface of CuSCN. The successful demonstration of the solution-processed inorganic HTL using simple and low temperature processing routes bodes well for the development of reliable and efficient flexible p-i-n perovskite modules or for integration as a front cell in hybrid tandem solar cells.

  19. WEO-2011 Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    There are few signs that the urgently needed change in direction in global energy trends is underway. Although the recovery in the world economy since 2009 has been uneven, and future economic prospects remain uncertain, global primary energy demand rebounded by a remarkable 5% in 2010, pushing CO2 emissions to a new high. Subsidies that encourage wasteful consumption of fossil fuels jumped to over $400 billion. The number of people without access to electricity remained unacceptably high at 1.3 billion, around 20% of the world's population. Despite the priority in many countries to increase energy efficiency, global energy intensity worsened for the second straight year. Against this unpromising background, events such as those at the Fukushima Daiichi nuclear power plant and the turmoil in parts of the Middle East and North Africa (MENA) have cast doubts on the reliability of energy supply, while concerns about sovereign financial integrity have shifted the focus of government attention away from energy policy and limited their means of policy intervention, boding ill for agreed global climate change objectives.

  20. Concise review: mesenchymal stem cells for diabetes.

    Science.gov (United States)

    Domínguez-Bendala, Juan; Lanzoni, Giacomo; Inverardi, Luca; Ricordi, Camillo

    2012-01-01

    Mesenchymal stem cells (MSCs) have already made their mark in the young field of regenerative medicine. Easily derived from many adult tissues, their therapeutic worth has already been validated for a number of conditions. Unlike embryonic stem cells, neither their procurement nor their use is deemed controversial. Here we review the potential use of MSCs for the treatment of type 1 diabetes mellitus, a devastating chronic disease in which the insulin-producing cells of the pancreas (the β-cells) are the target of an autoimmune process. It has been hypothesized that stem cell-derived β-cells may be used to replenish the islet mass in diabetic patients, making islet transplantation (a form of cell therapy that has already proven effective at clinically restoring normoglycemia) available to millions of prospective patients. Here we review the most current advances in the design and application of protocols for the differentiation of transplantable β-cells, with a special emphasis in analyzing MSC potency according to their tissue of origin. Although no single method appears to be ripe enough for clinical trials yet, recent progress in reprogramming (a biotechnological breakthrough that relativizes the thus far insurmountable barriers between embryonal germ layers) bodes well for the rise of MSCs as a potential weapon of choice to develop personalized therapies for type 1 diabetes.

  1. Dal manichino alla real doll. La bambola nella visualità contemporanea

    Directory of Open Access Journals (Sweden)

    Alessandra Olivares

    2014-12-01

    Full Text Available The doll, in its various manifestations of substitute of real woman for at least forty years is a subject at the heart of poetics of many artists that through it convey stereotypes, ideas and experiences related to the feminine universe. And yet over time is profoundly changed the way of understanding and representing this object, that is one of the most discussed and controversial of our time for the disturbing familiarity that does not leave indifferent those who observe. Particularly in the case of real dolls or sex dolls, so likely and cured in the minimums details to seem real. Disregarding the controversies and aspects related to the questionable erotic business that these dolls are part, what cannot be ignored is that more and more often they are at the heart of art projects that seem real psychological studies around the emotional sphere of the individual.There are many artists who through a skilful use of the photographic instrument, combined with set designed down to the smallest details, accessories and poses, committed their search around the possibility to transpire emotions from a subject who notoriously cannot try them.But why is it so important to provide with a soul these inanimate bodies? Why do we so much need of these surrogates to bring out human feelings and emotions?After excessive and obsessive use of the poetics of the doll in the Surrealism, starting in the 1970s, this subject is recovered and used as a kind of mirror to reflect the process of manipulation and reification of a body increasingly artificial, and advances in plastic surgery and genetic engineering as the crucial stages of the construction of a man-machine-thing. Among the exponents of this art, notoriously defined post-human, there are the pioneer Helmut Newton, followed by Cindy Sherman, Nick Knight, Charles Ray and Vanessa Beecroft, just to name a few.What however that is investigated is the inversion of march that we see in many artists. In the poetics

  2. Direct comparison of the FibroScan XL and M probes for assessment of liver fibrosis in obese and nonobese patients

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    Durango E

    2013-07-01

    Full Text Available Esteban Durango,1,* Christian Dietrich,1,* Helmut Karl Seitz,1 Cornelia Ursula Kunz,2 Gilles T Pomier-Layrargues,3 Andres Duarte-Rojo,4 Melanie Beaton,5 Magdy Elkhashab,6 Robert P Myers,7 Sebastian Mueller1,3 1Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, 2Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany; 3Liver Unit, Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, Montréal, Quebec, 4Toronto Western Hospital Liver Centre, Toronto, Ontario; 5Multi-Organ Transplant Unit, University of Western Ontario, London, Ontario; 6The Toronto Liver Centre, Toronto, Ontario; 7Liver Unit, Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada *These authors contributed equally to this researchBackground: A novel Fibroscan XL probe has recently been introduced and validated for obese patients, and has a diagnostic accuracy comparable with that of the standard M probe. The aim of this study was to analyze and understand the differences between these two probes in nonobese patients, to identify underlying causes for these differences, and to develop a practical algorithm to translate results for the XL probe to those for the M probe.Methods and results: Both probes were directly compared first in copolymer phantoms of varying stiffness (4.8, 11, and 40 kPa and then in 371 obese and nonobese patients (body mass index, range 17.2–72.4 from German (n = 129 and Canadian (n = 242 centers. Liver stiffness values for both probes correlated better in phantoms than in patients (r = 0.98 versus 0.82, P 10 kPa for F0, F1–2, F3, and F4 fibrosis, respectively significantly improved agreement between the two probes from r = 0.655 to 0.679.Conclusion: Liver stiffness can be measured in significantly more obese and nonobese patients using the XL probe than the M probe. However, the XL

  3. BOOK REVIEW: Great Physicists - The Life and Times of Leading Physicists from Galileo to Hawking

    Science.gov (United States)

    Cropper, William H.

    2002-11-01

    might occasionally miss a proper mention of their scientific heroes. These slightly critical observations should not obscure the impression that the chemist Cropper has succeeded with his goal of writing a very useful and informative book, displaying great understanding of the life of the physicists, their ingenious theoretical ideas and experimental discoveries. Simultaneously he has provided a pleasantly readable account of the great success story of physics extending over the past three hundred years. Both laymen and professionals may like to have the book in their public or private libraries. Helmut Rechenberg

  4. Out of the Shadows

    Science.gov (United States)

    Byers, Nina; Williams, Gary

    2010-12-01

    Foreword Freeman J. Dyson; Introduction Nina Byers; 1. Hertha Aryton 1854-1923 Joan Mason; 2. Margaret Maltby 1860-1944 Peggy Kidwell; 3. Agnes Pockels 1862-1935 Gary A. Williams; 4. Marie Curie 1867-1934 A. Pais; 5. Henrietta Leavitt 1868-1921 Jean L. Turner; 6. Harriet Brooks 1876-1933 C. W. Wong; 7. Lise Meitner 1878-1968 Ruth Lewin Sime; 8. Emmy Noether 1882-1935 Nina Byers; 9. Inge Lehmann 1888-1993 Bruce A. Bolt; 10. Marietta Blau 1894-1970 Leopold Halpern and Maurice M. Shapiro; 11. Hertha Sponer 1895-1968 Helmut Rechenberg; 12. Irene Joliot-Curie 1897-1956 Hélène Langevin-Joliot and Pierre Radvanyi; 13. Katherine Burr Blodgett 1898-1979 Gary A. Williams; 14. Cecilia Payne Gaposchkin 1900-1979 Vera C. Rubin; 15. Mary Cartwright 1900-1998 Freeman J. Dyson; 16. Bertha Jeffreys 1903-1999 Ruth M. Williams; 17. Kathleen Yardley Lonsdale1903-1971 Judith Milledge; 18. Maria Goeppert Mayer 1906-1972 Steven A. Moszkowski; 19. Helen Megaw 1907-2002 A. Michael Glazer and Christine Kelsey; 20. Yvette Cauchois 1908-1999 Christiane Bonnelle; 21. Marguerite Perey 1909-1975 Jean-Pierre Adloff and George B. Kauffman; 22. Dorothy Crowfoot Hodgkin 1910-1994 Jenny P. Glusker; 23. Gertrude Scharff Goldhaber 1911-1998 Alfred Scharff Goldhaber; 24. Chien Shiung Wu 1912-1997 Noemie Bencze-Koller; 25. Margaret E. Burbidge 1919 Virginia Trimble; 26. Phyllis Freier 1921-1992 Cecil J. Waddington; 27. Rosalyn S. Yalow 1921 M. S. Dresselhaus and F. A. Stahl; 28. Esther Conwell 1922 Lewis Rothberg; 29. Cecile Dewitt-Morette 1922 Bryce DeWitt; 30. Yvonne Choquet-Bruhat 1923 James W. York Jr.; 31. Vera Rubin 1928 Robert J. Rubin; 32. Mildred S. Dresselhaus 1930 G. Dresselhaus and F. A. Stahl; 33. Myriam Sarachik 1933 Jonathan R. Friedman; 34. Juliet Lee-Franzini 1933 Paolo Franzini; 35. Helen T. Edwards 1936 John Peoples; 36. Mary K. Gaillard 1939 Andreszej Buras; 37. Renata Kallosh 1943 Andrei Linde and Michael Gutperle; 38. Jocelyn Bell Burnell 1943 Ferdinand V. Coroniti and Gary A

  5. Correlates of preferences for autonomy in long-term care: results of a population-based survey among older individuals in Germany

    Directory of Open Access Journals (Sweden)

    Hajek A

    2018-01-01

    Full Text Available André Hajek,1 Thomas Lehnert,1 Annemarie Wegener,1 Steffi G Riedel-Heller,2 Hans-Helmut König1 1Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, 2Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany Purpose: Thus far, there is little evidence concerning the factors associated with preferences for autonomy in long-term care. Therefore, the aim of the present study was to investigate the correlates of preferences for autonomy in long-term care among older individuals in Germany. Methods: Data were gathered from a population-based survey of the German population aged ≥65 years in 2015 (N=1,006. Results: Multiple logistic regressions revealed that preferences for freedom of choice for foods were positively associated with living with partner or spouse (OR: 1.5 [1.0–2.2], being born in Germany (OR: 1.9 [1.1–3.3], and lower self-rated health (OR: 1.3 [1.1–1.6]. Preferences for freedom in choosing bedtime and sleep duration were positively associated with lower age (OR: 1.1 [1.0–1.1] and having children (OR: 2.2 [1.0–4.9]. Preferences for customized living space were positively associated with being female (OR: 2.5 [1.4–4.5] and being born in Germany (OR: 3.7 [1.9–7.1]. Neither preferences for decent and sanitary housing nor preferences for shared decision-making were associated with any of the independent variables. Conclusion: Various independent variables were associated with preferences for autonomy in long-term care. This suggests that preferences for care-related autonomy are complex. Knowing these might help refine long-term care health services. Keywords: caregivers, older adult, long-term care, Germany

  6. Mid-term outcomes of patients with PCI prior to CABG in comparison to patients with primary CABG

    Directory of Open Access Journals (Sweden)

    Sandra Eifert

    2010-06-01

    Full Text Available Sandra Eifert1, Helmut Mair1, Anne-Laure Boulesteix2, Eckehard Kilian1, Martin Adamczak1, Bruno Reichart1, Peter Lamm11Department of Cardiac Surgery, 2Department of Medical Informatics, Biometry and Epidemiology (IBE, Ludwig Maximilians University, Munich, GermanyAbstract: The number of percutaneous coronary interventions (PCI prior to coronary artery bypass grafting (CABG increased drastically during the last decade. Patients are referred for CABG with more severe coronary pathology, which may influence postoperative outcome. Outcomes of 200 CABG patients, collected consecutively in an observational study, were compared (mean follow-up: 5 years. Group A (n = 100, mean age 63 years, 20 women had prior PCI before CABG, and group B (n = 100, mean age 66, 20 women underwent primary CABG. In group A, the mean number of administered stents was 2. Statistically significant results were obtained for the following preoperative criteria: previous myocardial infarction: 54 vs 34 (P = 0.007, distribution of CAD (P < 0.0001, unstable angina: 27 vs 5 (P < 0.0001. For intraoperative data, the total number of established bypasses was 2.43 ± 1.08 vs 2.08 ± 1.08 (P = 0.017, with the number of arterial bypass grafts being: 1.26 ± 0.82 vs 1.07 ± 0.54 (P = 0.006. Regarding the postoperative course, significant results could be demonstrated for: adrenaline dosage (0.83 vs 0.41 mg/h; [p is not significant (ns] administered in 67 group A vs 47 group B patients (P = 0.006, and noradrenaline dosage (0.82 vs 0.87 mg/h; ns administered in 46 group A vs 63 group B patients (P = 0.023, CK/troponine I (P = 0.002; P < 0.001, postoperative resuscitation (6 vs 0; P = 0.029, intra aortic balloon pump 12 vs 1 (P = 0.003, and 30-day mortality (9% in group A vs 1% in group B; P = 0.018. Clopidogrel was administered in 35% of patients with prior PCI and in 19% of patients without prior PCI (P = 0.016. Patients with prior PCI presented for CABG with more severe CAD. Morbidity

  7. Anthroposophic therapy for asthma: A two-year prospective cohort study in routine outpatient settings

    Directory of Open Access Journals (Sweden)

    Harald J Hamre

    2009-11-01

    Full Text Available Harald J Hamre1, Claudia M Witt2, Gunver S Kienle1, Christof Schnürer3, Anja Glockmann1, Renatus Ziegler4, Stefan N Willich2, Helmut Kiene11Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany; 2Institute of Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, Germany; 3Internal Medicine Practice, A Fraenkel Centrum, Badenweiler, Germany; 4Society for Cancer Research, Arlesheim, SwitzerlandBackground: Anthroposophic treatment for asthma includes special artistic and physical therapies and special medications.Methods: We studied consecutive outpatients starting anthroposophic treatment for asthma under routine conditions in Germany. Main outcomes were average asthma severity (0–10, primary outcome; symptoms (1–4; and asthma-related quality of life at 12-month follow-up (Asthma Quality of Life Questionnaire [AQLQ] overall score, 1–7, for adults; KINDL Questionnaire for Measuring Health-Related Quality of Life in Children and Adolescents, asthma module, 0–100, for children at 12-month follow-up.Results: Ninety patients (54 adults, 36 children were included. Anthroposophic treatment modalities used were medications (88% of patients, n = 79/90; eurythmy therapy (22%; art therapy (10%; and rhythmical massage therapy (1%. Median number of eurythmy/art/massage sessions was 12 (interquartile range 10–20, median therapy duration was 120 days (84–184. From baseline to 12-month follow-up, all outcomes improved significantly (P < 0.001 for all comparisons. Average improvements were: average asthma severity 2.61 points (95% confidence interval CI: 1.90–3.32; cough 0.93 (95% CI: 0.60–1.25; dyspnea 0.92 (95% CI: 0.56–1.28; exertion-induced symptoms 0.95 (95% CI: 0.64–1.25; frequency of asthma attacks 0.78 (95% CI:0.41–1.14; awakening from asthma 0.90 (95% CI: 0.58–1.21; AQLQ overall score 1.44 (95% CI:0.97–1.92; and KINDL asthma module 14.74 (95% CI: 9.70–19

  8. Anthroposophic therapy for attention deficit hyperactivity: A two-year prospective study in outpatients

    Directory of Open Access Journals (Sweden)

    Harald J Hamre

    2010-08-01

    Full Text Available Harald J Hamre1, Claudia M Witt2, Gunver S Kienle1, Christoph Meinecke3, Anja Glockmann1, Renatus Ziegler4, Stefan N Willich2, Helmut Kiene11Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany; 2Institute of Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, Germany; 3Pediatric Consultant, Community Hospital Havelhöhe, Berlin, Germany; 4Society for Cancer Research, Arlesheim, SwitzerlandBackground: Anthroposophic treatment for attention deficit hyperactivity disorder (ADHD includes special artistic and physical therapies and special medications.Methods: We studied 61 consecutive children starting anthroposophic treatment for ADHD symptoms under routine outpatient conditions. Primary outcome was FBB-HKS (a parents’ questionnaire for ADHD core symptoms, 0–3, and secondary outcomes were disease and symptom scores (physicians’ and parents’ assessment, 0–10 and quality of life (KINDL® total score, 0–100.Results: A total of 67% of patients fulfilled the DSM-IV criteria for ADHD, 15% had an exclusion diagnosis such as pervasive developmental disorders, while 18% did not fulfill ADHD criteria for another reason. Anthroposophic treatment modalities used were eurythmy therapy (in 56% of patients, art therapy (20%, rhythmical massage therapy (8%, and medications (51%. From baseline to six-month follow-up, all outcomes improved significantly; average improvements were FBB-HKS total score 0.30 points (95% confidence interval [CI]: 0.18–0.43; P < 0.001, FBB-HKS inattention 0.36 (95% CI: 0.21–0.50; P < 0.001, FBB-HKS hyperactivity 0.29 (95% CI: 0.14–0.44; P < 0.001, FBB-HKS impulsivity 0.22 (95% CI: 0.03–0.40; P < 0.001, disease score 2.33 (95% CI: 1.84–2.82; P < 0.001, symptom score 1.66 (95% CI: 1.17–2.16; P < 0.001, and KINDL 5.37 (95% CI: 2.27–8.47; P = 0.001. Improvements were similar in patients not using stimulants (90% of patients at months 0–6 and

  9. SIX DECADES OF THE PULA NEUROPSYCHIATRIC MEETINGS--FROM NEUROPSYCHIATRY TO BORDERLANDS OF NEUROLOGY AND PSYCHIATRY BRAIN AND MIND.

    Science.gov (United States)

    Barac, Bosko; Demarin, Vida

    2015-12-01

    In 2010, the International Neuropsychiatric Pula Symposia, from 2005 Congresses (INPS/INPC), founded in 1961 by Zagreb and Graz University Neuropsychiatry Departments, celebrated their 50th anniversary of successful development. The co-author of the paper, Bosko Barac, witnessed their growth from 1966, collaborating in their organization from 1974 with the first Secretary General Gerald Grinschgl; elected for his successor after his unexpected death in 1985, he was leading the Kuratorium (Scientific Board) as Secretary General for 23 years, collaborating in this period with his Austrian partner and friend Helmut Lechner. In 2007, Barac handed over this responsible function to the co-author Vida Demarin. Starting when neuropsychiatry was a unique discipline, the INPC followed the processes of emancipation of neurology and psychiatry and their evolution to independent disciplines with new subspecialties. These respectable conferences greatly surpassed the significance of the two disciplines, neurology and psychiatry, granting collaboration of borderland medical and non-medical disciplines, connecting experts from the region, European countries and the world. Inaugurated in 'cold-war' times, in their first phase they enabled to make professional and human contacts between scientists from the two divided 'blocs' thanks to the 'non-aligned' position of the then Yugoslavia, fostering the ideas of mutual understanding and collaboration. On the other hand, the scientific development of the meetings took in the center of their study fields connecting the two disciplines, giving a quite unique quality to these meetings. For many years, the meetings cherished specific neurologic and psychiatric topics, at the same time planning increasing important topics of the 'borderland areas' in their programs. For the important achievements, they earned the title of the Pula School of Science and Humanism, promoting interdisciplinary scientific collaboration important for humanistic

  10. Gender differences in predictors of health status in patients with COPD Preditores do estado de saúde em pacientes com DPOC de acordo com o gênero

    Directory of Open Access Journals (Sweden)

    Renata Ferrari

    2010-02-01

    Full Text Available OBJECTIVE: To evaluate the health status (HS of COPD patients and to identify the main predictors of HS in these patients according to gender. METHODS: The study included 90 COPD patients (60 males and 30 females; mean age = 64 ± 9 years with a wide range of airway obstruction disorders (mean FEV1 = 56 ± 19% of predicted. The men were individually matched to the women by % of predicted FEV1 (ratio: 2:1. The patients were assessed regarding body composition; six-minute walk distance; perception of dyspnea using the Modified Medical Research Council Dyspnea Scale; Saint George's Respiratory Questionnaire (SGRQ; Charlson comorbidity index; and the multidimensional Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE index. Multiple linear regression analysis was performed to identify the predictors of HS by gender. RESULTS: Impairment of HS was greater among the women than among the men for SGRQ total score and for all SGRQ domains (total: 51 ± 18% vs. 38 ± 19%; p = 0.002; symptoms: 61 ± 22% vs. 42 ± 21%; p OBJETIVO: Avaliar o estado de saúde (ES de pacientes com DPOC e identificar os principais preditores do ES nesses pacientes de acordo com o gênero. MÉTODOS: Participaram do estudo 90 pacientes com DPOC (60 homens e 30 mulheres; idade média = 64 ± 9 anos com ampla faixa de distúrbios obstrutivos (VEF1 = 56 ± 19% do predito. Os homens foram pareados individualmente às mulheres em função de VEF1 % do predito (razão 2:1. Os pacientes foram avaliados em relação à sua composição corporal, distância percorrida no teste de caminhada de seis minutos; percepção da dispneia através da Modified Medical Research Council Dyspnea Scale; Saint George's Respiratory Questionnaire (SGRQ; índice de comorbidade de Charlson; e índice Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE multidimensional. A análise de regressão linear múltipla foi feita para identificar os preditores do ES por g

  11. A relação capacidade inspiratória / capacidade pulmonar total (IC/TLC é preditiva da mortalidade na DPOC

    Directory of Open Access Journals (Sweden)

    C. Casanova

    2005-07-01

    Full Text Available Resumo: Foram estudados em dois centros americanos (Flórida e Boston e dois espanhóis (Saragoça e Tenerife 689 doentes entre Dezembro de 1995 e Agosto de 2003, com uma média de estudo de 34 meses.A definição de DPOC foi: exposição tabágica> 20 UMA e FEV1/FVC pós-broncodilatador 25% estavam 58% dos doentes e abaixo de 25% os restantes (42%.A mortalidade nos doentes com IC/TLC 25%.O índice BODE, TM6m, IC/TLC e índice de Charlson foram os melhores preditores de mortalidade global e estes mais a dispneia (MRC para mortalidade de causa respiratória. A relação IC/TLC foi independente do índice BODE como factor preditivo de mortalidade. A correlação entre IC/TLC, MRC e TM6m foi significativa mas não superior à obtida para o FEV1, o que significa que IC/TLC traduz alteração funcional pulmonar, mas de uma forma diferente da do FEV1. Também IC/TLC se correlaciona melhor com o BMI do que FEV1, reflectindo melhor o impacto da gravidade da DPOC.Uma vez que IC/TLC é um excelente parâmetro preditivo de mortalidade, poderá ser esta a explicação para a redução na mortalidade dos doentes que efectuaram cirurgia de redução de volume no estudo NETT.Por último, Celli e o seu grupo propõem que a relação IC/TLC seja designada por «Fracção Inspiratória» por analogia com a “Fracção de Ejecção” utilizada pela cardiologia e de elevado significado clínico.Assim, estes autores recomendam a medição de IC/ /TLC ou Fracção Inspiratória com os outros parâmetros funcionais clássicos para uma avaliação correcta dos doentes com DPOC.

  12. Hegel, Analogy, and Extraterrestrial Life

    Science.gov (United States)

    Ross, Joseph T.

    Georg Wilhelm Friedrich Hegel rejected the possibility of life outside of the Earth, according to several scholars of extraterrestrial life. Their position is that the solar system and specifically the planet Earth is the unique place in the cosmos where life, intelligence, and rationality can be. The present study offers a very different interpretation of Hegel's statements about the place of life on Earth by suggesting that, although Hegel did not believe that there were other solar systems where rationality is present, he did in fact suggest that planets in general, not the Earth exclusively, have life and possibly also intelligent inhabitants. Analogical syllogisms are superficial, according to Hegel, insofar as they try to conclude that there is life on the Moon even though there is no evidence of water or air on that body. Similar analogical arguments for life on the Sun made by Johann Elert Bode and William Herschel were considered by Hegel to be equally superficial. Analogical arguments were also used by astronomers and philosophers to suggest that life could be found on other planets in our solar system. Hegel offers no critique of analogical arguments for life on other planets, and in fact Hegel believed that life would be found on other planets. Planets, after all, have meteorological processes and therefore are "living" according to his philosophical account, unlike the Moon, Sun, and comets. Whereas William Herschel was already finding great similarities between the Sun and the stars and had extended these similarities to the property of having planets or being themselves inhabitable worlds, Hegel rejected this analogy. The Sun and stars have some properties in common, but for Hegel one cannot conclude from these similarities to the necessity that stars have planets. Hegel's arguments against the presence of life in the solar system were not directed against other planets, but rather against the Sun and Moon, both of which he said have a different

  13. Evaluation of body composition in COPD patients using multifrequency bioelectrical impedance analysis

    Directory of Open Access Journals (Sweden)

    de Blasio F

    2016-09-01

    expiratory volume in 1 second (P<0.05 and vital capacity (P<0.005. Finally, the 5/250 impedance ratio was reduced (P<0.05 in patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD III and IV (compared to those with GOLD I and II or a BODE index between 6 and 10 points (compared to those with BODE index between 1 and 5 points.Conclusion: MF-BIA may be a useful tool for assessing body composition and nutritional status in COPD patients. In particular, the impedance ratio could give valuable information on cellular integrity and muscle quality.Keywords: muscle quality, impedance ratio, muscle strength

  14. Self-organizing systems in planetary physics: Harmonic resonances of planet and moon orbits

    Science.gov (United States)

    Aschwanden, Markus J.

    2018-01-01

    The geometric arrangement of planet and moon orbits into a regularly spaced pattern of distances is the result of a self-organizing system. The positive feedback mechanism that operates a self-organizing system is accomplished by harmonic orbit resonances, leading to long-term stable planet and moon orbits in solar or stellar systems. The distance pattern of planets was originally described by the empirical Titius-Bode law, and by a generalized version with a constant geometric progression factor (corresponding to logarithmic spacing). We find that the orbital periods Ti and planet distances Ri from the Sun are not consistent with logarithmic spacing, but rather follow the quantized scaling (Ri + 1 /Ri) =(Ti + 1 /Ti) 2 / 3 =(Hi + 1 /Hi) 2 / 3 , where the harmonic ratios are given by five dominant resonances, namely (Hi + 1 :Hi) =(3 : 2) ,(5 : 3) ,(2 : 1) ,(5 : 2) ,(3 : 1) . We find that the orbital period ratios tend to follow the quantized harmonic ratios in increasing order. We apply this harmonic orbit resonance model to the planets and moons in our solar system, and to the exo-planets of 55 Cnc and HD 10180 planetary systems. The model allows us a prediction of missing planets in each planetary system, based on the quasi-regular self-organizing pattern of harmonic orbit resonance zones. We predict 7 (and 4) missing exo-planets around the star 55 Cnc (and HD 10180). The accuracy of the predicted planet and moon distances amounts to a few percents. All analyzed systems are found to have ≈ 10 resonant zones that can be occupied with planets (or moons) in long-term stable orbits.

  15. Understanding of COPD among final-year medical students

    Science.gov (United States)

    Mohigefer, Javier; Calero-Acuña, Carmen; Marquez-Martin, Eduardo; Ortega-Ruiz, Francisco; Lopez-Campos, Jose Luis

    2018-01-01

    Objective Several previous studies have shown a suboptimal level of understanding of COPD among different population groups. Students in their final year of Medicine constitute a population that has yet to be explored. The evaluation of their understanding provides an opportunity to establish strategies to improve teaching processes. The objective of the present study is to determine the current level of understanding of COPD among said population. Methods A cross-sectional observational study was done using digital surveys given to medical students in their final year at the Universidad de Sevilla. Those surveyed were asked about demographic data, smoking habits as well as the clinical manifestation, diagnosis and treatment of COPD. Results Of the 338 students contacted, responses were collected from 211 of them (62.4%). Only 25.2% had an accurate idea about the concept of the disease. The study found that 24.0% of students were familiar with the three main symptoms of COPD. Tobacco use was not considered a main risk factor for COPD by 1.5% of students. Of those surveyed, 22.8% did not know how to spirometrically diagnose COPD. Inhaled corticosteroids were believed to be part of the main treatment for this disease among 51.0% of the students. Results show that 36.4% of respondents believed that home oxygen therapy does not help COPD patients live longer. Only 15.0% considered the Body-mass index, airflow Obstruction, Dyspnea, and Exercise (BODE) index to be an important parameter for measuring the severity of COPD. Giving up smoking was not believed to prevent worsening COPD among 3.4% of students surveyed. Almost half of students (47.1%) did not recommend that those suffering from COPD undertake exercise. Conclusion The moderate level of understanding among the population of medical students in their final year shows some strengths and some shortcomings. Teaching intervention is required to reinforce solid knowledge among this population. PMID:29343952

  16. David Bowie and the Art of Slow Innovation: A Fast-Second Winner Strategy for Biotechnology and Precision Medicine Global Development.

    Science.gov (United States)

    Özdemir, Vural; Patrinos, George P

    2017-11-01

    Original ideas and innovation cannot always be ordered like a courier service and delivered fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions, science and biotechnology innovation included, emphasize the speed as the prevailing ideology. But a narrow focus on speed has several and overlooked shortcomings. For example, it does not offer the opportunity to draw from, and stitch together disparate concepts and practices for truly disruptive innovation. Preventing false starts, learning from others' or our own mistakes, and customizing innovations for local community needs are difficult in a speed-hungry innovation ecosystem. We introduce a new strategy, the Fast-Second Winner, specifically in relation to global development of biotechnologies and precision medicine. This à la carte global development strategy envisions a midstream entry into the innovation ecosystem. Moreover, we draw from the works of the late David Bowie who defied rigid classifications as an artist and prolific innovator, and introduce the concept and practice of slow innovation that bodes well with the Fast-Second Winner strategy. A type of slow innovation, the Fast-Second Winner is actually fast and sustainable in the long term, and efficient by reducing false starts in new precision medicine application contexts and geographies, learning from other innovators' failures, and shaping innovations for the local community needs. The establishment of Centers for Fast-Second Innovation (CFSIs), and their funding, for example, by crowdfunding and other innovative mechanisms, could be timely for omics and precision medicine global development. If precision medicine is about tailoring drug treatments and various health interventions to individuals, we suggest to start from tailoring new ideas, and focus not only on how much we innovate but also what and how we innovate. In principle, the Fast-Second Winner can be applied to omics and other biotechnology

  17. A complete mitochondrial genome sequence from a mesolithic wild aurochs (Bos primigenius).

    LENUS (Irish Health Repository)

    Edwards, Ceiridwen J

    2010-01-01

    aurochsen haplogroup (haplogroup P), thus providing novel insights into pre-domestic patterns of variation. The high proportion of authentic, endogenous aurochs DNA preserved in this sample bodes well for future efforts to determine the complete genome sequence of a wild ancestor of domestic cattle.

  18. Crosslinked polymer nanoparticles containing single conjugated polymer chains

    Science.gov (United States)

    Ponzio, Rodrigo A.; Marcato, Yésica L.; Gómez, María L.; Waiman, Carolina V.; Chesta, Carlos A.; Palacios, Rodrigo E.

    2017-06-01

    Conjugated polymer nanoparticles are widely used in fluorescent labeling and sensing, as they have mean radii between 5 and 100 nm, narrow size dispersion, high brightness, and are photochemically stable, allowing single particle detection with high spatial and temporal resolution. Highly crosslinked polymers formed by linking individual chains through covalent bonds yield high-strength rigid materials capable of withstanding dissolution by organic solvents. Hence, the combination of crosslinked polymers and conjugated polymers in a nanoparticulated material presents the possibility of interesting applications that require the combined properties of constituent polymers and nanosized dimension. In the present work, F8BT@pEGDMA nanoparticles composed of poly(ethylene glycol dimethacrylate) (pEGDMA; a crosslinked polymer) and containing the commercial conjugated polymer poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT) were synthesized and characterized. Microemulsion polymerization was applied to produce F8BT@pEDGMA particles with nanosized dimensions in a ∼25% yield. Photophysical and size distribution properties of F8BT@pEDGMA nanoparticles were evaluated by various methods, in particular single particle fluorescence microscopy techniques. The results demonstrate that the crosslinking/polymerization process imparts structural rigidity to the F8BT@pEDGMA particles by providing resistance against dissolution/disintegration in organic solvents. The synthesized fluorescent crosslinked nanoparticles contain (for the most part) single F8BT chains and can be detected at the single particle level, using fluorescence microscopy, which bodes well for their potential application as molecularly imprinted polymer fluorescent nanosensors with high spatial and temporal resolution.

  19. Photoelectrochemical oxidation of ibuprofen via Cu{sub 2}O-doped TiO{sub 2} nanotube arrays

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Qiannan [College of Environment and Energy, South China University of Technology, Guangzhou (China); Peng, Yen-Ping, E-mail: yppeng@thu.edu.tw [Department of Environmental Science and Engineering, Tunghai University, Taichung, Taiwan (China); Chen, Hanlin [College of Environment and Energy, South China University of Technology, Guangzhou (China); Chang, Ken-Lin [School of Environmental Science and Engineering and Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 51006 China (China); Qiu, Yang-Neng; Lai, Shiau-Wu [Department of Environmental Science and Engineering, Tunghai University, Taichung, Taiwan (China)

    2016-12-05

    Highlights: • A p–n junction material was synthesized to enhance photocatalytic ability. • Cu{sub 2}O-doped TiO{sub 2} nanotube arrays works as a photoanode in a PEC system. • Recombination of photo-generated holes and electrons were greatly reduced. • Synergetic effect was quantified in PEC degradation. • Recombination of photogenerated holes and electrons was greatly enhanced. - Abstract: A p–n junction based Cu{sub 2}O-doped TiO{sub 2} nanotube arrays (Cu{sub 2}O-TNAs) were synthesized and used as a working anode in a photoelectrochemical (PEC) system. The results revealed that the Cu{sub 2}O-TNAs were dominated by the anatase phase and responded significantly to visible light. XPS analyses indicated that with an amount of 24.79% Cu doping into the structure, the band gap of Cu{sub 2}O-TNAs was greatly reduced. SEM images revealed that the supported TiO{sub 2} nanotubes had diameters of approximately 80 nm and lengths of about 2.63 μm. Upon doping with Cu{sub 2}O, the TiO{sub 2} nanotubes maintained their structural integrity, exhibiting no significant morphological change, favoring PEC applications. Under illumination, the photocurrent from Cu{sub 2}O/TNAs was 2.4 times larger than that from TNAs, implying that doping with Cu{sub 2}O significantly improved electron mobility by reducing the rate of recombination of electron-hole pairs. The EIS and Bode plot revealed that the estimated electron lifetimes, τ{sub el}, of TNAs and Cu{sub 2}O/TNAs were 6.91 and 26.26 ms, respectively. The efficiencies of degradation of Ibuprofen by photoelectrochemical, photocatalytic (PC), electrochemical (EC) and photolytic (P) methods were measured.

  20. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

    Science.gov (United States)

    Gendron, Tania F; Chew, Jeannie; Stankowski, Jeannette N; Hayes, Lindsey R; Zhang, Yong-Jie; Prudencio, Mercedes; Carlomagno, Yari; Daughrity, Lillian M; Jansen-West, Karen; Perkerson, Emilie A; O'Raw, Aliesha; Cook, Casey; Pregent, Luc; Belzil, Veronique; van Blitterswijk, Marka; Tabassian, Lilia J; Lee, Chris W; Yue, Mei; Tong, Jimei; Song, Yuping; Castanedes-Casey, Monica; Rousseau, Linda; Phillips, Virginia; Dickson, Dennis W; Rademakers, Rosa; Fryer, John D; Rush, Beth K; Pedraza, Otto; Caputo, Ana M; Desaro, Pamela; Palmucci, Carla; Robertson, Amelia; Heckman, Michael G; Diehl, Nancy N; Wiggs, Edythe; Tierney, Michael; Braun, Laura; Farren, Jennifer; Lacomis, David; Ladha, Shafeeq; Fournier, Christina N; McCluskey, Leo F; Elman, Lauren B; Toledo, Jon B; McBride, Jennifer D; Tiloca, Cinzia; Morelli, Claudia; Poletti, Barbara; Solca, Federica; Prelle, Alessandro; Wuu, Joanne; Jockel-Balsarotti, Jennifer; Rigo, Frank; Ambrose, Christine; Datta, Abhishek; Yang, Weixing; Raitcheva, Denitza; Antognetti, Giovanna; McCampbell, Alexander; Van Swieten, John C; Miller, Bruce L; Boxer, Adam L; Brown, Robert H; Bowser, Robert; Miller, Timothy M; Trojanowski, John Q; Grossman, Murray; Berry, James D; Hu, William T; Ratti, Antonia; Traynor, Bryan J; Disney, Matthew D; Benatar, Michael; Silani, Vincenzo; Glass, Jonathan D; Floeter, Mary Kay; Rothstein, Jeffrey D; Boylan, Kevin B; Petrucelli, Leonard

    2017-03-29

    There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. However, discovery of a G4C2 repeat expansion in the C9ORF72 gene as the most common genetic cause of ALS has opened up new avenues for therapeutic intervention for this form of ALS. G4C2 repeat expansion RNAs and proteins of repeating dipeptides synthesized from these transcripts are believed to play a key role in C9ORF72-associated ALS (c9ALS). Therapeutics that target G4C2 RNA, such as antisense oligonucleotides (ASOs) and small molecules, are thus being actively investigated. A limitation in moving such treatments from bench to bedside is a lack of pharmacodynamic markers for use in clinical trials. We explored whether poly(GP) proteins translated from G4C2 RNA could serve such a purpose. Poly(GP) proteins were detected in cerebrospinal fluid (CSF) and in peripheral blood mononuclear cells from c9ALS patients and, notably, from asymptomatic C9ORF72 mutation carriers. Moreover, CSF poly(GP) proteins remained relatively constant over time, boding well for their use in gauging biochemical responses to potential treatments. Treating c9ALS patient cells or a mouse model of c9ALS with ASOs that target G4C2 RNA resulted in decreased intracellular and extracellular poly(GP) proteins. This decrease paralleled reductions in G4C2 RNA and downstream G4C2 RNA-mediated events. These findings indicate that tracking poly(GP) proteins in CSF could provide a means to assess target engagement of G4C2 RNA-based therapies in symptomatic C9ORF72 repeat expansion carriers and presymptomatic individuals who are expected to benefit from early therapeutic intervention. Copyright © 2017, American Association for the Advancement of Science.

  1. Influence of comorbidities on the efficacy of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Higashimoto, Yuji; Yamagata, Toshiyuki; Maeda, Kazushige; Honda, Noritsugu; Sano, Akiko; Nishiyama, Osamu; Sano, Hiroyuki; Iwanaga, Takashi; Chiba, Yasutaka; Fukuda, Kanji; Tohda, Yuji

    2016-08-01

    To evaluate the influence of comorbidities and aging on pulmonary rehabilitation (PR) efficacy in patients with chronic obstructive pulmonary disease (COPD). This was a retrospective cohort study of patients with COPD attending an outpatient PR program. Comorbidity information was collected with the Charlson Index, BODE index and COPD-specific comorbidity test, and also included other common conditions not included in these indexes. The efficacy of PR was defined as a 54-m increase in 6-min walk distance or a four-point decrease in St. George's Respiratory Questionnaire score. Patients were divided into two age groups according to the median age of 72 years. A total of 21 of 52 patients (40%) showed a clinically significant benefit by the 6-min walk distance, and 29 patients (55.8%) by the St. George's Respiratory Questionnaire score. PR efficacy was not different between the elderly group and the younger group by either parameter. A total of 98% of the patients had at least one chronic comorbidity. Hypertension was the most frequently reported comorbidity (28.5%). Higher body mass index, Hospital Anxiety and Depression Scale anxiety score and St. George's Respiratory Questionnaire total score were associated with a good response to PR by the 6-min walk distance. None of the individual comorbidities or indexes were correlated with the efficacy of PR. Multiple logistic regression analysis showed that body mass index was independently associated with the response to PR. PR is equally effective in elderly and younger patients with COPD, with efficacy influenced by body mass index and anxiety. Geriatr Gerontol Int 2016; 16: 934-941. © 2015 Japan Geriatrics Society.

  2. A strong-lensing elliptical galaxy in the MaNGA survey

    Science.gov (United States)

    Smith, Russell J.

    2017-01-01

    I report discovery of a new galaxy-scale gravitational lens system, identified using public data from the Mapping Galaxies at Apache Point Observatory (MaNGA) survey, as part of a systematic search for lensed background line emitters. The lens is SDSS J170124.01+372258.0, a giant elliptical galaxy with velocity dispersion σ = 256 km s-1, at a redshift of zl = 0.122. After modelling and subtracting the target galaxy light, the integral-field data cube reveals [O II], [O III] and Hβ emission lines corresponding to a source at zs = 0.791, forming an identifiable ring around the galaxy centre. If the ring is formed by a single lensed source, then the Einstein radius is REin ≈ 2.3 arcsec, projecting to ˜5 kpc at the distance of the lens. The total projected lensing mass is MEin = (3.6 ± 0.6) × 1011 M⊙, and the total J-band mass-to-light ratio is 3.0 ± 0.7 solar units. Plausible estimates of the likely dark matter content could reconcile this with a Milky Way-like initial mass function (IMF), for which M/L ≈ 1.5 is expected, but heavier IMFs are by no means excluded with the present data. An alternative interpretation of the system, with a more complex source plane, is also discussed. The discovery of this system bodes well for future lens searches based on MaNGA and other integral-field spectroscopic surveys.

  3. Gender Differences in Plasma Biomarker Levels in a Cohort of COPD Patients: A Pilot Study

    Science.gov (United States)

    de Torres, Juan P.; Casanova, Ciro; Pinto-Plata, Victor; Varo, Nerea; Restituto, Patricia; Cordoba-Lanus, Elizabeth; Baz-Dávila, Rebeca; Aguirre-Jaime, Armando; Celli, Bartolome R.

    2011-01-01

    Rationale Little is known about gender differences in plasma biomarker levels in patients with chronic obstructive pulmonary disease (COPD). Hypothesis There are differences in serum biomarker levels between women and men with COPD. Objective Explore gender differences in plasma biomarker levels in patients with COPD and smokers without COPD. Methods We measured plasma levels of IL-6, IL-8, IL-16, MCP-1, MMP-9, PARC and VEGF in 80 smokers without COPD (40 males, 40 females) and 152 stable COPD patients (76 males, 76 females) with similar airflow obstruction. We determined anthropometrics, smoking history, lung function, exercise tolerance, body composition, BODE index, co-morbidities and quality of life. We then explored associations between plasma biomarkers levels and the clinical characteristics of the patients and also with the clinical and physiological variables known to predict outcome in COPD. Results The plasma biomarkers level explored were similar in men and women without COPD. In contrast, in patients with COPD the median value in pg/mL of IL-6 (6.26 vs 8.0, p = 0.03), IL-16 (390 vs 321, p = 0.009) and VEGF (50 vs 87, p = 0.02) differed between women and men. Adjusted for smoking history, gender was independently associated with IL-16, PARC and VEGF levels. There were also gender differences in the associations between IL-6, IL-16 and VEGF and physiologic variables that predict outcomes. Conclusions In stable COPD patients with similar airflow obstruction, there are gender differences in plasma biomarker levels and in the association between biomarker levels and important clinical or physiological variables. Further studies should confirm our findings. PMID:21267454

  4. USA aborts international family planning.

    Science.gov (United States)

    Potts, M

    1996-03-02

    The US Agency for International Development (USAID) has been a leader in international family planning for almost 30 years, accounting for 46% of all funds in international family planning provided by OECD countries during 1991. Moreover, relative to other donor countries, the US supplies worldwide a disproportionate amount of contraceptives. While international family planning activities received $546 million in 1995, the budget was slashed in 1996 to $72 million. This unprecedented cut will have a profound effect upon the reproductive health and family planning choices of tens of millions of people in developing countries. Millions of additional unintended pregnancies and maternal and child deaths may result. 1996 began with the White House and Congress in political gridlock, with negotiations on foreign aid stalled on the issue of abortion. The Republican-led House of Representatives wanted to bar support of any nongovernmental organization (NGO) which also provided information on abortion, while Democratic President Bill Clinton affirmed that he would veto such legislation. At the end of January, the House passed the Balanced Budget and Down Payment Act (HR 2880) containing clauses which cut the aid budget by 35% and barring new money in the area of family planning until July 1. Spending was limited to the allocation of 6.5% of the total budget each month. Some social marketing programmers who distribute condoms and oral contraceptives are already feeling the pinch, and some programs will simply run out of contraceptives. This cut in funding also bodes ill for achieving the goals of the 1994 International Conference on Population and Development. There is, however, hope that the cuts will be reversed for the next fiscal year. The author notes survey findings which indicate that US citizens support higher budgets for family planning.

  5. Biomimetic electroactive polyimide with rose petal-like surface structure for anticorrosive coating application

    Directory of Open Access Journals (Sweden)

    W. F. Ji

    2017-08-01

    Full Text Available In this work, an electroactive polyimide (EPI coating with biomimetic surface structure of rose petal used in anticorrosion application was first presented. First of all, amino-capped aniline trimer (ACAT was synthesized by oxidative coupling reaction, followed by characterized through Fourier transform infrared spectroscooy (FTIR, liquid chromatography – mass spcerometry (LC-MS and proton nuclear magnetic resonance (1H-NMR spectroscopy. Subsequently, as-prepared ACAT was reacted with isopropylidenediphenoxy-bis(phthalic anhydride (BPADA to give electroactive poly(amic acid (EPAA. Moreover, poly(dimethylsiloxane (PDMS was used to be the soft negative template for pattern transfer from the surface of rose petal to the surface of polymer coating. The EPI coating with biomimetic structure was obtained by programmed heating the EPAA slurry casting onto the negative PDMS template. The anticorrosive performance of as-prepared biomimetic EPI coating was demonstrated by performing a series of electrochemical measurements (Tafel, Nyquist, and Bode plots upon cold-rolled steel (CRS electrode in a NaCl aqueous solution. It should be noted that the biomimetic EPI coating with rose petal-like structure was found to exhibit better anticorrosion than that of EPI without biomimetic structure. Moreover, the surface contact angle of water droplets for biomimetic EPI coating was found to be ~150°, which is significantly higher than that of EPI coating with smooth structure (~87°, indicating that the EPI coating with biomimetic structure reveals better hydrophobicity. The apparent mechanism for improved anticorrosive properties is twofold: (1 the biomimetic structure of EPI coating can repel water droplets. (2 electroactivity of EPI coating promotes the formation of densely passive layer of metal oxide on metallic surface.

  6. X-linked nephrogenic diabetes insipidus: From the ship Hopewell to RFLP studies

    Energy Technology Data Exchange (ETDEWEB)

    Bichet, D.G.; Lonergan, M.; Arthus, M.F.; Ligier, S.; Kluge, R. (Universite de Montreal (Canada)); Hendy, G.N.; Pausova, Z.; Zingg, H.; Morgan, K.; Saenger, P. (McGill Univ., Montreal (Canada)) (and others)

    1992-11-01

    Nephrogenic diabetes insipidus (NDI; designated 304800 in Mendelian Inheritance in Man) is an X-linked disorder with abnormal renal and extrarenal V[sub 2] vasopression receptor responses. The mutant gene has been mapped to Xq28 by analysis of RFLPs, and tight linkage between DXS52 and DNI has been reported. In 1969, Bode and Crawford proposed, under the term, the Hopewell hypothesis' that most cases in North America could be traced to descendants of Ulster Scots who arrived in Nova Scotia in 1761 on the ship Hopewell. They also suggested a link between this family and a large Mormon pedigree. DNA samples obtained from 13 independent affected families, including 42 members of the Hopewell and Mormon pedigrees, were analyzed with probes in the Xq28 region. Genealogical reconstructions were performed. Linkage between NDI and DXS304 (probe U6:2.spl), DXS305 (St35-691), DXS52 (St14-1), DXS15 (DX13), and F8C (F814) showed no recombination in 12 families, with a maximum lod score of 13.5 for DXS52. A recombinant between NDI and DXS304, DXS305, was identified in one family. The haplotype segregating with the disease in the Hopewell pedigree was not shared by other North American families. PCR analysis of the St14 VNTR allowed the distinction of two alleles that were not distinguishable by Southern analysis. Carrier status was predicted in 24 of 26 at-risk females. The Hopewell hypothesis cannot explain the origin of NDI in many of the North American families, since they have no apparent relationship with the Hopewell earlier settlers, either by haplotype or by genealogical analysis. PCR analysis of the DXS52 VNTR in NDI families is very useful for carrier testing and presymptomatic diagnosis, which can prevent the first manifestations of dehydration. 39 refs., 7 figs., 3 tabs.

  7. The Methane Isotopologues by Solar Occultation (MISO Nanosatellite Mission: Spectral Channel Optimization and Early Performance Analysis

    Directory of Open Access Journals (Sweden)

    Damien Weidmann

    2017-10-01

    Full Text Available MISO is an in-orbit demonstration mission that focuses on improving the representation of the methane distribution throughout the upper troposphere and stratosphere, to complement and augment the nadir- and zenith-looking methane observing system for a better understanding of the methane budget. MISO also aims to raise to space mission readiness the concept of laser heterodyne spectro-radiometry (LHR and associated miniaturization technologies, through demonstration of Doppler-limited atmospheric transmittance spectroscopy of methane from a nanosatellite platform suitable for future constellation deployment. The instrumental and engineering approach to MISO is briefly presented to demonstrate the technical feasibility of the mission. LHR operates using narrow spectral coverage (<1 cm−1 focusing on a few carefully chosen individual ro-vibrational transitions. A line-by-line spectral channel selection methodology is developed and used to optimize spectral channel selection relevant to methane isotopologue sounding from co-registered thermal infrared and short-wave infrared LHR. One of the selected windows is then used to carry out a first performance analysis of methane retrievals based on measurement noise propagation. This preliminary analysis of a single observation demonstrates an ideal instrumental precision of <1% for altitudes in the range 8–20 km, <5% for 20–30 km and <10% up to 37 km on a single isotopologue profile, which leaves a significant reserve for real-world error budget degradation and bodes well for the mission feasibility. MISO could realistically demonstrate methane limb sounding at Doppler-limited spectral resolution, even from a cost-effective 6 dm3 nanosatellite.

  8. Comparative secretome analysis of Trichoderma asperellum S4F8 and Trichoderma reesei Rut C30 during solid-state fermentation on sugarcane bagasse

    Science.gov (United States)

    2013-01-01

    Background The lignocellulosic enzymes of Trichoderma species have received particular attention with regard to biomass conversion to biofuels, but the production cost of these enzymes remains a significant hurdle for their commercial application. In this study, we quantitatively compared the lignocellulolytic enzyme profile of a newly isolated Trichoderma asperellum S4F8 strain with that of Trichoderma reesei Rut C30, cultured on sugarcane bagasse (SCB) using solid-state fermentation (SSF). Results Comparison of the lignocellulolytic enzyme profiles of S4F8 and Rut C30 showed that S4F8 had significantly higher hemicellulase and β-glucosidase enzyme activities. Liquid chromatography tandem mass spectrometry analysis of the two fungal secretomes enabled the detection of 815 proteins in total, with 418 and 397 proteins being specific for S4F8 and Rut C30, respectively, and 174 proteins being common to both strains. In-depth analysis of the associated biological functions and the representation of glycoside hydrolase family members within the two secretomes indicated that the S4F8 secretome contained a higher diversity of main and side chain hemicellulases and β-glucosidases, and an increased abundance of some of these proteins compared with the Rut C30 secretome. Conclusions In SCB SSF, T. asperellum S4F8 produced a more complex lignocellulolytic cocktail, with enhanced hemicellulose and cellobiose hydrolysis potential, compared with T. reesei Rut C30. This bodes well for the development of a more cost-effective and efficient lignocellulolytic enzyme cocktail from T. asperellum for lignocellulosic feedstock hydrolysis. PMID:24286470

  9. Incorporating translational research with clinical research to increase effectiveness in healthcare for better health.

    Science.gov (United States)

    Estape, Estela S; Mays, Mary Helen; Harrigan, Rosanne; Mayberry, Robert

    2014-01-01

    The transfer of new scientific discoveries into healthcare interventions requires that basic and clinical researchers work together with health care providers to generate team science. These innovative models require translational teams, and need to extend beyond the academic environment. The future of translational science requires partnerships with the healthcare community as well as the broader, general community. This new integrated model of effective translational teams holds promise for addressing thorny and persistent health disparities, is consistent with the nation's strategic priority of eliminating health disparities, and bodes well for increasing healthcare effectiveness aimed at better health for all. As part of the 13th Research Centers in Minority Institutions (RCMI) International Symposium on Health Disparities, several senior academic leaders joined efforts to hold a workshop to discuss a model that considers the incorporation of two translational research strategies in research career development programs: Comparative effectiveness research (CER) and community-based participatory research (CBPR) for increasing healthcare effectiveness and eliminating healthcare disparities. Discussion included what issues may be most germane to the concept of a unified model for research workforce development through formal training and career development leading to increased effectiveness in healthcare for better health. We believe that there is a gap in knowledge and skills in formal research career development programs that will enable physicians, other clinicians, and basic scientists to actively participate in these two translational research strategies. The purpose of this paper is to share the outcomes of these discussions, and encourage further discussion and possible innovation in the formulation of a new model for translational research workforce development.

  10. The complex planetary synchronization structure of the solar system

    Science.gov (United States)

    Scafetta, N.

    2014-01-01

    The complex planetary synchronization structure of the solar system, which since Pythagoras of Samos (ca. 570-495 BC) is known as the music of the spheres, is briefly reviewed from the Renaissance up to contemporary research. Copernicus' heliocentric model from 1543 suggested that the planets of our solar system form a kind of mutually ordered and quasi-synchronized system. From 1596 to 1619 Kepler formulated preliminary mathematical relations of approximate commensurabilities among the planets, which were later reformulated in the Titius-Bode rule (1766-1772), which successfully predicted the orbital position of Ceres and Uranus. Following the discovery of the ~ 11 yr sunspot cycle, in 1859 Wolf suggested that the observed solar variability could be approximately synchronized with the orbital movements of Venus, Earth, Jupiter and Saturn. Modern research has further confirmed that (1) the planetary orbital periods can be approximately deduced from a simple system of resonant frequencies; (2) the solar system oscillates with a specific set of gravitational frequencies, and many of them (e.g., within the range between 3 yr and 100 yr) can be approximately constructed as harmonics of a base period of ~ 178.38 yr; and (3) solar and climate records are also characterized by planetary harmonics from the monthly to the millennial timescales. This short review concludes with an emphasis on the contribution of the author's research on the empirical evidences and physical modeling of both solar and climate variability based on astronomical harmonics. The general conclusion is that the solar system works as a resonator characterized by a specific harmonic planetary structure that also synchronizes the Sun's activity and the Earth's climate. The special issue Pattern in solar variability, their planetary origin and terrestrial impacts (Mörner et al., 2013) further develops the ideas about the planetary-solar-terrestrial interaction with the personal contribution of 10

  11. Demographics of Investigators Involved in OSSA-Funded Research

    Science.gov (United States)

    Stern, S. Alan; Konkel, Ronald; Habegger, Jay; Byerly, Radford, Jr.

    1991-01-01

    The birth of the U.S. civil space program and the subsequent, dramatic growth in the ranks of the space science research population occurred in the 1950s and 1960s'. The large, post- Sputnik/ Apollo buildup in space program manpower is now approximately one career-lifetime in the past. It is therefore natural to anticipate that a large fraction of the space program engineers, scientists, and managers who pioneered the early exploration of space are approaching retirement. Such a "retirement wave" bodes both a loss of manpower and, more fundamentally, a loss of experience from the civil-space manpower base. Such losses could play a critical role constraining in NASA's ability to expand or maintain its technical capabilities. If this indeed applies to the NASA space science research population, then the potential for problems is exacerbated by the anticipated growth in flight rates, data volume, and data-set diversity which will accompany the planned expansion in the OSSA science effort during the 1990s and 2000s. The purpose of this study was to describe the OSSA PI/Co-I population and to determine the degree to which the OSSA space science investigator population faces a retirement wave, and to estimate the future population of PIs in the 1990-2010 era. To conduct such a study, we investigated the present demographics of the PI and Co-1 population contained in the NASA/OSSA Announcement of Opportunity (AO) mailing list. PIs represent the "leadership" class of the OSSA scientific researcher population, and Co-Is represent one important, oncoming component of the "replacement" generation. Using the PI population data, we then make projection estimates of the future PI population from 1991 through 2010, under various NASA growth/PI demand scenarios.

  12. Engineering muscle tissue for the fetus: getting ready for a strong life

    Directory of Open Access Journals (Sweden)

    George Joseph Christ

    2015-04-01

    Full Text Available Congenital malformations frequently involve either skeletal, smooth or cardiac tissues. When large parts of those tissues are damaged, the repair of the malformations is challenged by the fact that so much autologous tissue is missing. Current treatments require the use of prostheses or other therapies and are associated with a significant morbidity and mortality. Nonetheless, affected children have generally good survival rates and mostly normal schooling. As such, new therapeutic modalities need to represent significant improvements with clear safety profiles. Regenerative medicine and tissue engineering technologies have the potential to dramatically improve the treatment of any disease or disorder involving a lack of viable tissue. With respect to congenital soft tissue anomalies, the development of, for example, implantable muscle constructs would provide not only the usual desired elasticity and contractile proprieties, but should also be able to grow with the fetus and/or in the postnatal life. Such an approach would eliminate the need for multiple surgeries. However, the more widespread clinical applications of regenerative medicine and tissue engineering technologies require identification of the optimal indications, as well as further elucidation of the precise mechanisms and best methods (cells, scaffolds/biomaterials for achieving large functional tissue regeneration in those clinical indications. In short, despite some amazing scientific progress, significant safety and efficacy hurdles remain. However, the rapid preclinical advances in the field bode well for future applications. As such, translational researchers and clinicians alike need be informed and prepared to utilize these new techniques for the benefit of their patients, as soon as they are available. To this end, we review herein, the clinical need(s, potential applications, and the relevant preclinical studies that are currently guiding the field toward novel

  13. [Tissue engineering of parathyroid gland].

    Science.gov (United States)

    Iovino, F; Armano, G; Auriemma, P P; Sergio, R; De Sena, G; Capuozzo, V; Rosso, F; Marino, G; Papale, F; Grimaldi, A; Barbarisi, A

    2010-01-01

    The postoperative hypoparathyroidism is a not rare complication after total thyroidectomy and/or total parathyroidectomy. Attempts to transplant parathyroid tissue began in 1975 with the work of Wells, but still today results are disappointing. However, with the development of tissue engineering techniques, some experimental approaches to build artificial parathyroid are been made. Bioengineered device, actively secreting PTH, for transplant in patients with iatrogenic hypoparathyroidism is unavailable. Parathyroid cells were obtained from three chronic uremic patients in hemodialysis, operated for secondary hyperparathyroidism. Cell cultures in RPMI medium were subsequently seeded on collagen scaffold (three-dimensional matrix with slow biodegradation). Collagen is the major component of the extracellular matrix and thus is a good substrate for cell adhesion and growth. Culture media, with a low calcium concentration, were optimised to physiologically stimulate parathyroid hormone secretion. Cell cultures were morphologically observed in optical and electron (ESEM) microscopy and metabolically assayed by MTT method until the tenth week. Besides, concentration of parathyroid hormone in the culture medium has been measured for several weeks. After 24 hours of culture in RPMI, cells extracted from human parathyroid glands were nearly all adherent and organised in clusters to resemble the glandular organization. The cellular population consisted predominantly of parathyroid cells (90-95%). On collagen scaffolds, cells maintains an epithelial-like morphology also after 10 weeks, colonizing the scaffold surface and keeping a good proliferative rate with a discrete production of parathyroid hormone. The use of parathyroid cells extracted from patients with secondary hyperparathyroidism was certainly an appropriate choice that enabled us to achieve these results, that albeit partial bode well for the experimental in vivo animal model. The bioengineered scaffolds when

  14. A thematic cost-benefit analysis of a marine protected area.

    Science.gov (United States)

    Rees, Siân E; Attrill, Martin J; Austen, Melanie C; Mangi, Stephen C; Rodwell, Lynda D

    2013-01-15

    The implementation of Marine Protected Areas (MPAs) is ultimately a social endeavour to sustain or improve human well-being via the conservation of marine ecosystems. The degree to which ecological gains are realised can depend upon how economic, ecological and social costs (negative impacts) and benefits (positive impacts) are included in the designation and management process. Without the support of key stakeholder groups whose user rights have been affected by the creation of an MPA, human impacts cannot be reduced. This study analyses a three year dataset to understand the themes associated with the economic, environmental and social costs and benefits of an MPA in Lyme Bay, United Kingdom (UK) following its establishment in 2008. Methodologically, the paper presents an ecosystem based management framework for analysing costs and benefits. Two hundred and forty one individuals were interviewed via questionnaire between 2008 and 2010 to determine perceptions and the level of support towards the MPA. Results reveal that despite the contentious manner in which this MPA was established, support for the MPA is strong amongst the majority of stakeholder groups. The level of support and the reasons given for support vary between stakeholder groups. Overall, the stakeholders perceive the social, economic and environmental benefits of the MPA to outweigh the perceived costs. There have been clear social costs of the MPA policy and these have been borne by mobile and static gear fishermen and charter boat operators. Local support for this MPA bodes well for the development of a network of MPAs around the UK coast under the United Kingdom Marine and Coastal Access Act 2009. However, this initial optimism is at risk if stakeholder expectation is not managed and the management vacuum is not filled. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Climate Analogues for agricultural impact projection and adaptation – a reliability test

    Directory of Open Access Journals (Sweden)

    Swen P.M. Bos

    2015-10-01

    both analyses, it appeared that differences between baseline and analogue sites were mostly explained by non-climatic factors. This does not bode well for using the analogue approach

  16. Barium boron aluminum silicate glass system for solid state optical gas sensors

    Science.gov (United States)

    Da Silva, M. J.; Karczewski, J.; Jasinski, P.; Chrzan, A.; Kalinowski, P.; Szymczewska, D.; Jasinski, G.

    2016-11-01

    Recent increasing demand for new eco-friendly materials and for low cost fabrication process for use in optical sensors field, raise concern about alternative materials for this application. We have designed two glass-ceramics compositions from the quaternary ROAl2O3- SiO2-B2O3(R=Ba) alkali-earth aluminum silicate system, labeled B72 and B69, with high refractive index (>1.6), large values of Abbe number (94.0 and 53.0, respectively), and free of lead and arsenic. We present an analysis and discussion of experimental optical properties, thermal and thermo-chemical stability along with important properties such as transition temperature (Tg), onset of crystallization (Tx) as well transport properties as ionic conductivity behavior in the quaternary glass-ceramic system containing boron for use as optical sensors. Complex Impedance Spectra (Bode Plot) and Potentiodynamic Polarization curves (Tafel plots) measurements were carried out in the temperature range of 600 to 850°C. The most probable conductivity mechanism is a thermally activated process of mobile ions overcoming a potential barrier (EA), according to the Arrhenius regime. Here we report that charge transfer is caused by the flux of electrons, in the region of elevated temperatures (>700°C), and is affected by immiscibility of crystals, nucleation and growth type, that causes phase separation. We found conductivity (σ) values from 10-9 to 10-5 S/cm at temperatures between 700 and 850°C. Our results highlight a need for research on ion mobility in the glassy network above the transition range, and the effect cause by metastable immiscibility in the alkaline-earth glasses are exposed. The two glass compositions B72 and B69 can be tailored by proper use as glassy optical sensor.

  17. Static and Functional Balance in Individuals With COPD: Comparison With Healthy Controls and Differences According to Sex and Disease Severity.

    Science.gov (United States)

    de Castro, Larissa A; Ribeiro, Laís Rg; Mesquita, Rafael; de Carvalho, Débora R; Felcar, Josiane M; Merli, Myriam F; Fernandes, Karen Bp; da Silva, Rubens A; Teixeira, Denilson C; Spruit, Martijn A; Pitta, Fabio; Probst, Vanessa S

    2016-11-01

    Studies have shown that individuals with COPD have impaired body balance, probably caused by the disease's multisystemic manifestations plus age-related decline in balance, potentially increasing the risk of falling and its consequences. However, little is known about the profile of individuals with COPD who present balance impairments, especially related to sex and disease severity stages. The aim of this work was to compare static and functional balance between subjects with COPD and healthy controls and to check possible differences according to sex and degrees of disease severity. Forty-seven subjects with COPD and 25 healthy controls were included in this study. Their static balance was assessed in one-legged stance using a force platform and functional balance with the Timed Up and Go test. Additionally, participants performed spirometry, the 6-min walk test and isometric quadriceps maximal voluntary contraction assessment. Disease severity was classified according to the Global Initiative for Obstructive Lung Disease stages and BODE (body mass index, air-flow obstruction, dyspnea, and exercise capacity) scores. In comparison with healthy controls, subjects with COPD had worse static (center of pressure displacement area: 9.3 ± 1.9 cm(2) vs 11.6 ± 4.0 cm(2), respectively, P = .01) and functional balance (Timed Up and Go test: 8.5 ± 1.3 s vs 10.3 ± 1.8 s, respectively, P static balance in comparison with men for all parameters related to center of pressure (P balance results. Individuals with COPD had worse static and functional balance in comparison with healthy controls. Sex can mediate these results, depending on the type of balance evaluation (force platform or functional test). Balance performance was similar among the groups classified according to disease severity. Copyright © 2016 by Daedalus Enterprises.

  18. The subgrid-scale scalar variance under supercritical pressure conditions

    Science.gov (United States)

    Masi, Enrica; Bellan, Josette

    2011-08-01

    To model the subgrid-scale (SGS) scalar variance under supercritical-pressure conditions, an equation is first derived for it. This equation is considerably more complex than its equivalent for atmospheric-pressure conditions. Using a previously created direct numerical simulation (DNS) database of transitional states obtained for binary-species systems in the context of temporal mixing layers, the activity of terms in this equation is evaluated, and it is found that some of these new terms have magnitude comparable to that of governing terms in the classical equation. Most prominent among these new terms are those expressing the variation of diffusivity with thermodynamic variables and Soret terms having dissipative effects. Since models are not available for these new terms that would enable solving the SGS scalar variance equation, the adopted strategy is to directly model the SGS scalar variance. Two models are investigated for this quantity, both developed in the context of compressible flows. The first one is based on an approximate deconvolution approach and the second one is a gradient-like model which relies on a dynamic procedure using the Leonard term expansion. Both models are successful in reproducing the SGS scalar variance extracted from the filtered DNS database, and moreover, when used in the framework of a probability density function (PDF) approach in conjunction with the β-PDF, they excellently reproduce a filtered quantity which is a function of the scalar. For the dynamic model, the proportionality coefficient spans a small range of values through the layer cross-stream coordinate, boding well for the stability of large eddy simulations using this model.

  19. Can identification of a fourth domain of life be made from sequence data alone, and could it be done on Mars?

    Science.gov (United States)

    Poole, Anthony M; Willerslev, Eske

    2007-10-01

    A central question in astrobiology is whether life exists elsewhere in the universe. If so, is it related to Earth life? Technologies exist that enable identification of DNA- or RNA-based microbial life directly from environmental samples here on Earth. Such technologies could, in principle, be applied to the search for life elsewhere; indeed, efforts are underway to initiate such a search. However, surveying for nucleic acid-based life on other planets, if attempted, must be carried out with caution, owing to the risk of contamination by Earth-based life. Here we argue that the null hypothesis must be that any DNA discovered and sequenced from samples taken elsewhere in the universe are Earth-based contaminants. Experience from studies of low-biomass ancient DNA demonstrates that some results, by their very nature, will not enable complete rejection of the null hypothesis. In terms of eliminating contamination as an explanation of the data, there may be value in identification of sequences that lie outside the known diversity of the three domains of life. We therefore have examined whether a fourth domain could be readily identified from environmental DNA sequence data alone. We concluded that, even on Earth, this would be far from trivial, and we illustrate this point by way of examples drawn from the literature. Overall, our conclusions do not bode well for planned PCR-based surveys for life on Mars, and we argue that other independent biosignatures will be essential in corroborating any claims for the presence of life based on nucleic acid sequences.

  20. Intoxicação experimental por Indigofera suffruticosa em caprinos e ovinos

    Directory of Open Access Journals (Sweden)

    Anna P.M. de Figueiredo

    2012-02-01

    Full Text Available Indigofera suffruticosa é uma planta invasora, ção. Em um caprino e um ovino foram realizados os testes que causa anemia hemolítica com hemoglobinúria em bo-de fragilidade osmótica, determinação de hemoglobina e vinos e, experimentalmente, anemia sem hemoglobinúria metemoglobina e pesquisa de corpúsculos de Heinz. Foi em cobaios. O objetivo deste trabalho foi determinar a comprovado que em caprinos e ovinos, I. suffruticosa cautoxicidade de I. suffruticosa para caprinos e ovinos. Par-sa anemia hemolítica sem hemoglobinúria com formação tes aéreas da planta foram administradas a seis caprinos de corpúsculos de Heinz. Os animais recuperaram-se da e quatro ovinos em doses diárias de 10, 20 e 40g por kg anemia, total ou parcialmente, mesmo com a continuidade de peso vivo, durante períodos de 2 a 24 dias. Foram ava-da administração da planta. Oito a 12 horas após a coleliados os parâmetros hematológicos (hematócrito, níveis ta observa-se pigmento azulado na urina. Sugere-se que o de hemoglobina e contagem de hemácias e foi coletada pigmento seja anilina ou algum metabolito dessa substânurina para urinálise e observação de variações na coloracia e que a anilina seja o princípio ativo responsável pela hemólise causada por I. suffruticosa.