78 FR 43838 - Airworthiness Directives; Hamilton Sundstrand Corporation Propellers
2013-07-22
..., Engine & Propeller Directorate, Aircraft Certification Service. BILLING CODE 4910-13-P ...-48-AD RIN 2120-AA64 Airworthiness Directives; Hamilton Sundstrand Corporation Propellers AGENCY... had applied to certain Hamilton Sundstrand Corporation 14SF-7, 14SF-15, and 14SF-23 series...
2013-05-23
..., CT 06096-1010; or Hamilton Standard Division, One Hamilton Road, United Technologies Corporation, Mail Stop 1A-3-C63, Windsor Locks, CT 06096-1010; phone: 877-808-7575; fax: 860-660-0372; email: tech... corrosion to accumulate to critical limits. Hamilton Sundstrand developed, and we approved,...
78 FR 9001 - Airworthiness Directives; Hamilton Sundstrand Corporation Propellers
2013-02-07
... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation... armature, preventing the pump from feathering the propeller. This condition, if not corrected, could...
76 FR 7101 - Airworthiness Directives; Hamilton Sundstrand Propellers Model 247F Propellers
2011-02-09
... Aircraft Certification Office, FAA, Engine and Propeller Directorate, 12 New England Executive Park... Propellers Model 247F Propellers AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule... requires removing affected propeller blades from service. This AD was prompted by reports of blades...
Elizabeth Hamilton: Enlightenment Educator.
Russell, Rosalind
1986-01-01
Elizabeth Hamilton, an eighteenth- and early nineteenth-century Scottish writer on education, was one of the first to advocate the application of educational psychology to teaching. She introduced Pestalozzi's method to the English-reading public and argued for equal education for all children of both sexes and all social backgrounds. (LFL)
... be limited. Home Visit Global Sites Search Help? hs-CRP Share this page: Was this page helpful? Also ... it used? A high-sensitivity C-reactive protein (hs-CRP) test may be used to help evaluate an ...
Emory, Amber Elizabeth; Chirica, Dan Cristian; Doyle, Jim
2013-01-01
This presentation covered the original plan for the Hurricane and Severe Storm Sentinel (HS3) Data Catalog available through the ESPO HS3 mission page (http://espo.nasa.gov/missions/hs3/) and provided examples of Model Products, Operational Products, and Research (Instrument) Products from the 2012 field campaign. The presentation also covered lessons learned and suggested improvements to the Data Catalog for the upcoming 2013 HS3 field campaign.
Sánchez Santos, José Manuel (1967-)
2012-01-01
A materia Mecánica Clásica II forma parte do bloque que no Grao en Física se dedica á Mecánica Clásica, que é a parte da Física que estuda o movemento das partículas e os corpos materiais e que comprende a teoría iniciada por Galileo e Newton e desenvolvida nos séculos XVIII e XIX por Lagrange e Hamilton, incluíndo tamén a Relatividade Especial de Einstein. A materia divídese en catro bloques temáticos de similar peso e duración temporal. O primeiro deles ten un marcado carácter teóric...
Bufano, F.; Pignata, G.; Bersten, M.
2014-01-01
Observations spanning a large wavelength range, from X-ray to radio, of the Type IIb supernova 2011hs are presented, covering its evolution during the first year after explosion. The optical light curve presents a narrower shape and a fainter luminosity at peak than previously observed for Type I...
Determinant Sums for Undirected Hamiltonicity
Björklund, Andreas
2010-01-01
We present a Monte Carlo algorithm for Hamiltonicity detection in an $n$-vertex undirected graph running in $O^*(1.657^{n})$ time. To the best of our knowledge, this is the first superpolynomial improvement on the worst case runtime for the problem since the $O^*(2^n)$ bound established for TSP almost fifty years ago (Bellman 1962, Held and Karp 1962). It answers in part the first open problem in Woeginger's 2003 survey on exact algorithms for NP-hard problems. For bipartite graphs, we improve the bound to $O^*(1.414^{n})$ time. Both the bipartite and the general algorithm can be implemented to use space polynomial in $n$. We combine several recently resurrected ideas to get the results. Our main technical contribution is a new reduction inspired by the algebraic sieving method for $k$-Path (Koutis ICALP 2008, Williams IPL 2009). We introduce the Labeled Cycle Cover Sum in which we are set to count weighted arc labeled cycle covers over a finite field of characteristic two. We reduce Hamiltonicity to Labeled ...
High-Order Hamilton's Principle and the Hamilton's Principle of High-Order Lagrangian Function
ZHANG Ming-Jiang; ZHAO Hong-Xia; FANG Jian-Hui; MA Shan-Jun; LU Kai
2008-01-01
In this paper, based on the theorem of the high-order velocity energy, integration and variation principle, the high-order Hamilton's principle of general holonomic systems is given. Then, three-order Lagrangian equations and four-order Lagrangian equations are obtained from the high-order Hamilton's principle. Finally, the Hamilton's principle of high-order Lagrangian function is given.
Strebel differentials and Hamilton sequences
LI; Zhong(
2001-01-01
［1］Strebel, K., Point shift differentials and extremal quasiconformal mappings, Annale Acad. Scle. Fenn. Math., 1998, 23: 475 -494.［2］Gardiner, F. P., Approximation of infinite dimensional Teichmutller space, Trans. Amer. Soc., 1999, 282: 367-383.［3］Lakic, N. , The Strebel points, Comptemp. Math. , 1997, 211: 417-431.［4］Wu Sheng jian, Hamilton sequences for extremal quasiconformal mappings of the unit disc, Science in China, Ser. A, 1999,42(10): 1033-1042.［5］Li Zhong, Qi Yi, A note on point shift differentials, Science in China, Ser. A, 1999, 42(5): 449-455.［6］Hamilton, R. S., Extremal quasiconformal mappings with prescribed boundary values, Trans. Amer. Math. Soc. , 1969,138: 399-406.［7］Krushkal, S. , Extremal quasiconformal mappings, Sirbirsk. Mat. Zh., 1969, 10: 573-583.［8］Reich, E., Strebel, K., Extremal quasiconformal mappings with given boundary values, Contributions to Analysis, New York: Academic Press, 1974, 375-391.［9］Strebel, K. , On quasiconformal mappings of open Riemann surfaces, Commemt. Math. Helr., 1978, 53: 301-321.［10］Earle, C., Li Zhong, Extremal quasiconformal mappings in plane domains, Quasiconformal Mappings and Analysis A Col-lection of Papers Honoring F. W. Gehring, New York: Springer-Verlag, 1998, 141-158.［11］Strebel, K., On quadratic differentials and extremal quasiconforrnal mappings, in Proc. of the Intern. Congress of Math.,Vancouver, 1974.［12］Li Zhong, Some new results on the geometry of infinite dimensional Teichmuller space, in Proceedings of the 3rd International Colloquium on Finite or Infinite Dimensional Complex Analysis, 1995, 369-378.
An extended Hamilton — Jacobi method
Kozlov, Valery V.
2012-11-01
We develop a new method for solving Hamilton's canonical differential equations. The method is based on the search for invariant vortex manifolds of special type. In the case of Lagrangian (potential) manifolds, we arrive at the classical Hamilton — Jacobi method.
Hamilton optics: transformational theory of optics
Winston, Roland; Ge, Wenjun
2013-09-01
In 1824 William Rowan Hamilton presented a memoir to the Royal Irish Academy on Optics(Trans. R. Irish. Acacamy, XV, 1828), which was the foundation for transformational optics, classical mechanics, nonimaging optics and thermodynamical foundation of nonimaging optics,etc. It is useful for us even in 2013 to revisit the Hamilton resolution.
Digitization of the Mary Hamilton Papers
Gardner Anne-Christine
2017-03-01
Full Text Available Held at The John Rylands Library, Manchester, the Mary Hamilton Papers are a valuable, but still largely untapped resource for linguistic, cultural and literary studies focussing on the late eighteenth century. In her diaries Lady Mary Hamilton (1756-1816 documents daily life and friendships with intellectual figures of the time, for instance Horace Walpole and members of the Bluestocking circle, which included Elizabeth Montagu and Frances Burney. The archive also contains letters written to Lady Mary Hamilton by her family and other members of her social network.
Clean air Hamilton 2001 progress report
NONE
2002-05-01
This community initiative called Clean Air Hamilton was established to improve air quality in Hamilton, Ontario. It has been mandated to annually report on progress and provide advice with regard to current air quality issues. The quality of life of residents is improved as a result of the work performed by Clean Air Hamilton, and it also enhances Hamilton's image. Numerous inquiries have been received from City officials in several municipalities such as Toronto, Kitchener-Waterloo and Windsor as a testament to the success of the initiative. Financial support is received from all levels of government. The funding received from the Council has helped in attracting additional donations in support of this initiative. Clean Air Hamilton was involved in one capacity or another in research, emissions reduction projects and public awareness campaigns during 2001, and its contributions were valued at approximately 500,000 dollars. The City of Hamilton was awarded the United Nations for Human Settlements award as a result of Clean Air Hamilton's community process in local air quality improvement. In addition, the City received the Dubai International Award for Best Practices in Improving the Living Environment. Clean Air Hamilton is ready to move to the next phase, which requires moving current structures that supplements voluntary commitments with committed funding from key stakeholders. Since June 1996, the advisory level of 32 on the Air Pollution Index has not been reached, and rarely goes over 20. Throughout the 1990s, levels of toxics have decreased significantly. A three-year self-sustaining program should be developed and funding sought for those initiatives, discussions should be facilitated among industrial stakeholders when they address air quality issues, and research should continue to be supported and advice on current air quality issues be provided to City Council. 1 fig.
Hamilton's indicators of the force of selection
Baudisch, Annette
2005-01-01
To quantify the force of selection, Hamilton [Hamilton, W. D. (1966) J. Theor. Biol. 12, 12-45] derived expressions for the change in fitness with respect to age-specific mutations. Hamilton's indicators are decreasing functions of age. He concluded that senescence is inevitable: survival...... and fertility decline with age. I show that alternative parameterizations of mutational effects lead to indicators that can increase with age. I then consider the case of deleterious mutations with age-specific effects. In this case, it is the balance between mutation and selection pressure that determines...... the equilibrium number of mutations in a population. In this balance, the effects of different parameterizations cancel out, but only to a linear approximation. I show that mutation accumulation has little impact at ages when this linear approximation holds. When mutation accumulation matters, nonlinear effects...
Richard Hamilton: the Very Great Semiographer
Paul, Frédéric
2012-01-01
For fifty years and more, Richard Hamilton has been an enthralling artist. He was not only a Pop Art pioneer, but also one of its earliest theoreticians… before the United States pilfered the idea and turned it into a lucrative trademark—their industrial model inspiring the movement, but the formulae of Cubism and Surrealism, with the re-use of found objects by collage and assemblage, also playing their part. Hamilton is little known outside the United Kingdom, and has been signally overlooke...
Conformal invariance conserved quantity of Hamilton systems
Cai Jian-Le; Luo Shao-Kai; Mei Feng-Xiang
2008-01-01
This paper studies conformal invariance and comserved quantRies of Hamilton system.The definition and the determining equation of conformal invariance for Hamilton system are provided.The relationship between the conformal invariance and the Lie symmetry are discussed,and the necessary and sufficient condition that the conformal invariance would be the Lie symmetry of the system under the infinitesimal one-parameter transformation group is deduced.It gives the conserved quantities of the system and an example for illustration.
HS0139+0559, HS0229+8016, HS0506+7725 and HS0642+5049: Four new long-period cataclysmic variables
Aungwerojwit, A; Rodríguez-Gil, P; Hagen, H J; Harlaftis, E T; Papadimitriou, C; Lehto, H; Araújo-Betancor, S; Heber, U; Fried, R E; Engels, D; Katajainen, S
2005-01-01
We present time-resolved optical spectroscopy and photometry of four relatively bright (V~14.0-15.5) long-period cataclysmic variables (CVs) discovered in the Hamburg Quasar Survey: HS0139+0559, HS0229+8016, HS0506+7725 and HS0642+5049. Their respective orbital periods, 243.69+-0.49min, 232.550+-0.049min, 212.7+-0.2min and 225.90+-0.23min are determined from radial velocity and photometric variability studies. HS0506+7725 is characterised by strong Balmer and He emission lines, short-period (~10-20min) flickering and weak X-ray emission in the ROSAT All Sky Survey. The detection of a deep low state (~18.5) identifies HS0506+7725 as a member of the VY Scl stars. HS0139+0559, HS0229+8016 and HS0642+5049 display thick-disc like spectra and no or only weak flickering activity. HS0139+0559 and HS0229+8016 exhibit clean quasi-sinusoidal radial velocity varations of their emission lines but no or very little orbital photometric variability. In contrast, we detect no radial velocity variation in HS0642+5049 but a not...
Measuring Social Capital in Hamilton, Ontario
Kitchen, Peter; Williams, Allison; Simone, Dylan
2012-01-01
Social capital has been studied by academics for more than 20 years and within the past decade there has been an explosion of growth in research linking social capital to health. This paper investigates social capital in Hamilton, Ontario by way of a telephone survey of 1,002 households in three neighbourhood groups representing high, mixed and…
Measuring Social Capital in Hamilton, Ontario
Kitchen, Peter; Williams, Allison; Simone, Dylan
2012-01-01
Social capital has been studied by academics for more than 20 years and within the past decade there has been an explosion of growth in research linking social capital to health. This paper investigates social capital in Hamilton, Ontario by way of a telephone survey of 1,002 households in three neighbourhood groups representing high, mixed and…
The face of energy poverty in Hamilton
Cooper, T. [McQuesten Legal and Community Services, Hamilton, ON (Canada)
2007-07-01
In 1907, Hamilton, Ontario was known as the electric city, where jobs were plentiful and where the cheapest hydro power in the world was produced. This presentation stated that currently, Hamilton which faces one of the highest poverty rates in the province of Ontario, with 96,000 residents living below the low income cutoff. Heat and hydro costs have escalated and have driven more Hamiltonians into deep poverty. Several quotes from residents were presented along with photographs to illustrate the situation. A graph depicting poverty by age demographics was also provided. The presentation emphasized that there is a need for a housing emergency loan program and a utility arrears program for the City of Hamilton, as many tenants are struggling to survive without heat, gas or electricity. The presentation concluded that Hamilton is in need of an effective heat strategy during the summer cooling months because senior citizens, persons with disabilities and families living in low-income, poorly ventilated housing are particularly at risk during an extreme heat event. refs., tabs., figs.
Hamilton County: A Rural School District Profile.
Harned, Catherine
Using state education agency, census, industry employment and occupational information data, this paper provides a detailed picture of a rural school district in Southern Illinois. Mining and agriculture are the major industries in Hamilton County. The major mining employer closed in February 1988, and the drought of 1988 is likely to adversely…
Hamilton-Jacobi renormalization for Lifshitz spacetime
Baggio, M.; de Boer, J.; Holsheimer, K.
2012-01-01
Just like AdS spacetimes, Lifshitz spacetimes require counterterms in order to make the on-shell value of the bulk action finite. We study these counterterms using the Hamilton-Jacobi method. Rather than imposing boundary conditions from the start, we will derive suitable boundary conditions by
An unusual ophthalmic finding in Lane-Hamilton syndrome.
Villegas, Victor M; Rachitskaya, Aleksandra V; Lam, Byron L; McKeown, Craig A; Berrocal, Audina M
2014-12-01
Lane-Hamilton syndrome is a rare condition that is characterized by idiopathic pulmonary hemosiderosis and celiac disease. We report the case of an 18-month-old girl with Lane-Hamilton syndrome who had unilateral pigmentary retinopathy.
Conformal invariance and Hamilton Jacobi theory for dissipative systems
Kiehn, R. M.
1975-01-01
For certain dissipative systems, a comparison can be made between the Hamilton-Jacobi theory and the conformal invariance of action theory. The two concepts are not identical, but the conformal action theory covers the Hamilton-Jacobi theory.
VIABILITY SOLUTIONS TO STRUCTURED HAMILTON-JACOBI EQUATIONS UNDER CONSTRAINTS
2011-01-01
International audience; Structured Hamilton-Jacobi partial differential equations are Hamilton-Jacobi equations where the time variable is replaced by a vector-valued variable "structuring" the system. It could be the time-age pair (Hamilton-Jacobi-McKendrick equations) or candidates for initial or terminal conditions (Hamilton-Jacobi-Cournot equations) among a manifold of examples. Here, we define the concept of "viability solution" which always exists and can be computed by viability algori...
Hamilton Jacobi method for solving ordinary differential equations
Mei, Feng-Xiang; Wu, Hui-Bin; Zhang, Yong-Fa
2006-08-01
The Hamilton-Jacobi method for solving ordinary differential equations is presented in this paper. A system of ordinary differential equations of first order or second order can be expressed as a Hamilton system under certain conditions. Then the Hamilton-Jacobi method is used in the integration of the Hamilton system and the solution of the original ordinary differential equations can be found. Finally, an example is given to illustrate the application of the result.
Three-order pseudo-Hamilton canonical equations
Ma Shan-Jun; Huang Pei-Tian; Yan Rong; Zhao Hong-Xia
2006-01-01
Based on the three-order Lagrangian equations, Hamilton's function ofacceleration H* and generalized acceleration momentum P*α are defined, and pseudo-Hamilton canonical equations corresponding to three-order Lagrangian equations are obtained. The equations are similar to Hamilton's canonical equations of analytical mechanics in form.
Hamilton--Jacobi meet M\\"obius
Faraggi, Alon E
2015-01-01
Adaptation of the Hamilton--Jacobi formalism to quantum mechanics leads to a cocycle condition, which is invariant under $D$--dimensional M\\"obius transformations with Euclidean or Minkowski metrics. In this paper we aim to provide a pedagogical presentation of the proof of the M\\"obius symmetry underlying the cocycle condition. The M\\"obius symmetry implies energy quantization and undefinability of quantum trajectories, without assigning any prior interpretation to the wave function. As such, the Hamilton--Jacobi formalism, augmented with the global M\\"obius symmetry, provides an alternative starting point, to the axiomatic probability interpretation of the wave function, for the formulation of quantum mechanics and the quantum spacetime. The M\\"obius symmetry can only be implemented consistently if spatial space is compact, and correspondingly if there exist a finite ultraviolet length scale. Evidence for non--trivial space topology may exist in the cosmic microwave background radiation.
Quantum Potential Via General Hamilton - Jacobi Equation
Mollai, Maedeh; Jami, Safa; Ahanj, Ali
2011-01-01
In this paper, we sketch and emphasize the automatic emergence of a quantum potential (QP) in general Hamilton-Jacobi equation via commuting relations, quantum canonical transformations and without the straight effect of wave function. The interpretation of QP in terms of independent entity is discussed along with the introduction of quantum kinetic energy. The method has been extended to relativistic regime, and same results have been concluded.
Covariant Hamilton equations for field theory
Giachetta, Giovanni [Department of Mathematics and Physics, University of Camerino, Camerino (Italy); Mangiarotti, Luigi [Department of Mathematics and Physics, University of Camerino, Camerino (Italy)]. E-mail: mangiaro@camserv.unicam.it; Sardanashvily, Gennadi [Department of Theoretical Physics, Physics Faculty, Moscow State University, Moscow (Russian Federation)]. E-mail: sard@grav.phys.msu.su
1999-09-24
We study the relations between the equations of first-order Lagrangian field theory on fibre bundles and the covariant Hamilton equations on the finite-dimensional polysymplectic phase space of covariant Hamiltonian field theory. If a Lagrangian is hyperregular, these equations are equivalent. A degenerate Lagrangian requires a set of associated Hamiltonian forms in order to exhaust all solutions of the Euler-Lagrange equations. The case of quadratic degenerate Lagrangians is studied in detail. (author)
Canonical equations of Hamilton with beautiful symmetry
Liang, Guo; Guo, Qi
2012-01-01
The Hamiltonian formulation plays the essential role in constructing the framework of modern physics. In this paper, a new form of canonical equations of Hamilton with the complete symmetry is obtained, which are valid not only for the first-order differential system, but also for the second-order differential system. The conventional form of the canonical equations without the symmetry [Goldstein et al., Classical Mechanics, 3rd ed, Addison-Wesley, 2001] are only for the second-order differe...
Fifty years with the Hamilton scales for anxiety and depression. A tribute to Max Hamilton
Bech, P
2009-01-01
From the moment Max Hamilton started his psychiatric education, he considered psychometrics to be a scientific discipline on a par with biochemistry or pharmacology in clinical research. His clinimetric skills were in operation in the 1950s when randomised clinical trials were established...... as the method for the evaluation of the clinical effects of psychotropic drugs. Inspired by Eysenck, Hamilton took the long route around factor analysis in order to qualify his scales for anxiety (HAM-A) and depression (HAM-D) as scientific tools. From the moment when, 50 years ago, Hamilton published his first...... placebo-controlled trial with an experimental anti-anxiety drug, he realized the dialectic problem in using the total score on HAM-A as a sufficient statistic for the measurement of outcome. This dialectic problem has been investigated for more than 50 years with different types of factor analyses without...
Hamilton Graph Based on DNA Computing
ZHANGJia-xiu
2004-01-01
DNA computing is a novel method for solving a class of intractable computationalproblems in which the computing can grow exponentially with problem size. Up to now, manyaccomplishments have been achieved to improve its performance and increase its reliability.Hamilton Graph Problem has been solved by means of molecular biology techniques. A smallgraph was encoded in molecules of DNA, and the “operations” of the computation wereperformed with standard protocols and enzymes. This work represents further evidence forthe ability of DNA computing to solve NP-complete search problems.
Algebra and geometry of Hamilton's quaternions
Krishnaswami, Govind S
2016-01-01
Inspired by the relation between the algebra of complex numbers and plane geometry, William Rowan Hamilton sought an algebra of triples for application to three dimensional geometry. Unable to multiply and divide triples, he invented a non-commutative division algebra of quadruples, in what he considered his most significant work, generalizing the real and complex number systems. We give a motivated introduction to quaternions and discuss how they are related to Pauli matrices, rotations in three dimensions, the three sphere, the group SU(2) and the celebrated Hopf fibrations.
Hamilton-Jacobi Method and Gravitation
Di Criscienzo, R; Zerbini, S
2010-01-01
Studying the behaviour of a quantum field in a classical, curved, spacetime is an extraordinary task which nobody is able to take on at present time. Independently by the fact that such problem is not likely to be solved soon, still we possess the instruments to perform exact predictions in special, highly symmetric, conditions. Aim of the present contribution is to show how it is possible to extract quantitative information about a variety of physical phenomena in very general situations by virtue of the so-called Hamilton-Jacobi method. In particular, we shall prove the agreement of such semi-classical method with exact results of quantum field theoretic calculations.
Hamilton-Jacobi Method and Gravitation
di Criscienzo, R.; Vanzo, L.; Zerbini, S.
Studying the behaviour of a quantum field in a classical, curved, spacetime is an extraordinary task which nobody is able to take on at present time. Independently by the fact that such problem is not likely to be solved soon, still we possess the instruments to perform exact predictions in special, highly symmetric, conditions. Aim of the present contribution is to show how it is possible to extract quantitative information about a variety of physical phenomena in very general situations by virtue of the so-called Hamilton-Jacobi method. In particular, we shall prove the agreement of such semi-classical method with exact results of quantum field theoretic calculations.
Italian Validation of Homophobia Scale (HS
Giacomo Ciocca, PsyD, PhD
2015-09-01
Conclusions: The Italian validation of the HS revealed the use of this self‐report test to have good psychometric properties. This study offers a new tool to assess homophobia. In this regard, the HS can be introduced into the clinical praxis and into programs for the prevention of homophobic behavior. Ciocca G, Capuano N, Tuziak B, Mollaioli D, Limoncin E, Valsecchi D, Carosa E, Gravina GL, Gianfrilli D, Lenzi A, and Jannini EA. Italian validation of Homophobia Scale (HS. Sex Med 2015;3:213–218.
Hamilton y el Descubrimiento de los Cuaterniones
José Manuel Sánchez Muñoz
2011-10-01
Full Text Available Este artículo pretende ofrecer una visión general del descubrimiento de los llamados cuaterniones por parte del matemático irlandés William Rowan Hamilton. Se pretende dar al lector algunos detalles del nacimiento de los números imaginarios en el siglo XVI, su interpretación geométrica a principios del siglo XIX, y la extensión del plano complejo a las tres dimensiones a través de los cuaterniones, que abrirían el paso al estudio y el desarrollo de las nuevas álgebras no conmutativas y a una nueva interpretación tridimensional de la realidad física.
Viscous warm inflation: Hamilton-Jacobi formalism
Akhtari, L.; Mohammadi, A.; Sayar, K.; Saaidi, Kh.
2017-04-01
Using Hamilton-Jacobi formalism, the scenario of warm inflation with viscous pressure is considered. The formalism gives a way of computing the slow-rolling parameter without extra approximation, and it is well-known as a powerful method in cold inflation. The model is studied in detail for three different cases of the dissipation and bulk viscous pressure coefficients. In the first case where both coefficients are taken as constant, it is shown that the case could not portray warm inflationary scenario compatible with observational data even it is possible to restrict the model parameters. For other cases, the results shows that the model could properly predicts the perturbation parameters in which they stay in perfect agreement with Planck data. As a further argument, r -ns and αs -ns are drown that show the acquired result could stand in acceptable area expressing a compatibility with observational data.
Hamilton-Jacobi skeleton on cortical surfaces.
Shi, Y; Thompson, P M; Dinov, I; Toga, A W
2008-05-01
In this paper, we propose a new method to construct graphical representations of cortical folding patterns by computing skeletons on triangulated cortical surfaces. In our approach, a cortical surface is first partitioned into sulcal and gyral regions via the solution of a variational problem using graph cuts, which can guarantee global optimality. After that, we extend the method of Hamilton-Jacobi skeleton [1] to subsets of triangulated surfaces, together with a geometrically intuitive pruning process that can trade off between skeleton complexity and the completeness of representing folding patterns. Compared with previous work that uses skeletons of 3-D volumes to represent sulcal patterns, the skeletons on cortical surfaces can be easily decomposed into branches and provide a simpler way to construct graphical representations of cortical morphometry. In our experiments, we demonstrate our method on two different cortical surface models, its ability of capturing major sulcal patterns and its application to compute skeletons of gyral regions.
Canonical equations of Hamilton with beautiful symmetry
Liang, Guo
2012-01-01
The Hamiltonian formulation plays the essential role in constructing the framework of modern physics. In this paper, a new form of canonical equations of Hamilton with the complete symmetry is obtained, which are valid not only for the first-order differential system, but also for the second-order differential system. The conventional form of the canonical equations without the symmetry [Goldstein et al., Classical Mechanics, 3rd ed, Addison-Wesley, 2001] are only for the second-order differential system. It is pointed out for the first time that the number of the canonical equations for the first-order differential system is half of that for the second-order differential system. The nonlinear Schr\\"{o}dinger equation, a universal first-order differential system, can be expressed with the new canonical equations in a consistent way.
Stability of Controlled Hamilton Systems Excited by Gaussian White Noise
SHANG Mei; GUO Yong-xin; MEI Feng-xiang
2008-01-01
A new method is introduced in this paper. This method can be used to study the stability of controlled holonomic Hamilton systems under disturbance of Gaussian white noise. At first, the motion equation of controlled holonomic Hamilton systems excited by Gaussian noise is formulated. A theory to stabilize the system is provided. Finally, one example is given to illustrate the application procedures.
On the Hamilton-Jacobi Treatment of Constrained Systems
Sami.I.Muslih; Hosam A.El-Zalan
2003-01-01
Systems with singular-higher order Lagrangians are investigated by two methods: Dirac method and Hamilton-Jacobi method. An example is studied and it is shown that the Hamilton-Jacobi method gives the correct canonical generalized equations of motion, contrary to Dirac method, where Dirac conjecture is invalid.
Invariant surfaces and tracking by the Hamilton-Jacobi method
Warnock, R.L.; Ruth, R.D.
1986-09-01
The Hamilton-Jacobi method is described for a model of betatron motion in one degree of freedom, namely, a harmonic oscillator perturbed by a lattice of sextupoles. The Hamilton-Jacobi equation is given in terms of Fourier amplitudes. Invariant surfaces have been obtained in phase space, and finite time symplectic maps were obtained for tracking of single particles. (LEW)
Italian Validation of Homophobia Scale (HS).
Ciocca, Giacomo; Capuano, Nicolina; Tuziak, Bogdan; Mollaioli, Daniele; Limoncin, Erika; Valsecchi, Diana; Carosa, Eleonora; Gravina, Giovanni L; Gianfrilli, Daniele; Lenzi, Andrea; Jannini, Emmanuele A
2015-09-01
The Homophobia Scale (HS) is a valid tool to assess homophobia. This test is self-reporting, composed of 25 items, which assesses a total score and three factors linked to homophobia: behavior/negative affect, affect/behavioral aggression, and negative cognition. The aim of this study was to validate the HS in the Italian context. An Italian translation of the HS was carried out by two bilingual people, after which an English native translated the test back into the English language. A psychologist and sexologist checked the translated items from a clinical point of view. We recruited 100 subjects aged18-65 for the Italian validation of the HS. The Pearson coefficient and Cronbach's α coefficient were performed to test the test-retest reliability and internal consistency. A sociodemographic questionnaire including the main information as age, geographic distribution, partnership status, education, religious orientation, and sex orientation was administrated together with the translated version of HS. The analysis of the internal consistency showed an overall Cronbach's α coefficient of 0.92. In the four domains, the Cronbach's α coefficient was 0.90 in behavior/negative affect, 0.94 in affect/behavioral aggression, and 0.92 in negative cognition, whereas in the total score was 0.86. The test-retest reliability showed the following results: the HS total score was r = 0.93 (P homophobia. In this regard, the HS can be introduced into the clinical praxis and into programs for the prevention of homophobic behavior.
HS06 Benchmark for an ARM Server
Kluth, Stefan
2014-06-01
We benchmarked an ARM cortex-A9 based server system with a four-core CPU running at 1.1 GHz. The system used Ubuntu 12.04 as operating system and the HEPSPEC 2006 (HS06) benchmarking suite was compiled natively with gcc-4.4 on the system. The benchmark was run for various settings of the relevant gcc compiler options. We did not find significant influence from the compiler options on the benchmark result. The final HS06 benchmark result is 10.4.
HS06 Benchmark for an ARM Server
Kluth, Stefan
2013-01-01
We benchmarked an ARM cortex-A9 based server system with a four-core CPU running at 1.1 GHz. The system used Ubuntu 12.04 as operating system and the HEPSPEC 2006 (HS06) benchmarking suite was compiled natively with gcc-4.4 on the system. The benchmark was run for various settings of the relevant gcc compiler options. We did not find significant influence from the compiler options on the benchmark result. The final HS06 benchmark result is 10.4.
A Hamilton-Jacobi Formalism for Thermodynamics
Rajeev, S G
2007-01-01
We show that classical thermodynamics has a formulation in terms of Hamilton-Jacobi theory, analogous to mechanics. Even though the thermodynamic variables come in conjugate pairs such as pressure/volume or temperature/entropy, the phase space is odd-dimensional. For a system with \\m{n} thermodynamic degrees of freedom it is \\m{2n+1}-dimensional. The equations of state of a substance pick out an \\m{n}-dimensional submanifold. A family of substances whose equations of state depend on \\m{n} parameters define a hypersurface of co-dimension one. This can be described by the vanishing of a function which plays the role of a Hamiltonian. The ordinary differential equations (characteristic equations) defined by this function describe a dynamical system on the hypersurface. Its orbits can be used to reconstruct the equations of state. The `time' variable associated to this dynamics is related to, but is not identical to, entropy. After developing this formalism on well-grounded systems such as the van der Waals gases...
Sam D. Hamilton Noxubee National Wildlife Refuge: Comprehensive Conservation Plan
US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Sam D. Hamilton Noxubee NWR for the next 15 years. This plan outlines the Refuge vision...
Hamilton-Jakobi method for classical mechanics in Grassmann algebra
Tabunshchyk, K. V.
1998-01-01
We present the Hamilton-Jakobi method for the classical mechanics with constrains in Grassmann algebra. In the frame of this method the solution for the classical system characterized by the SUSY Lagrangian is obtained.
Hamilton´s Principle and Electric Circuits Tudory
2006-01-01
In the theory of electrical or electromechanical circuits different methods are known for construction of mathematical model. In this paper another, alternative method is introduced that is based on Hamilton variational principle that is generally valid in physics.
Researcher Profile: An Interview with Axton Betz-Hamilton
Axton Betz-Hamilton
2015-07-01
Full Text Available Dr. Axton Betz-Hamilton teaches consumer studies courses at Eastern Illinois University, including Personal and Family Finance, Housing, and Consumer Issues. She conducts research on identity theft as well as financial abuse within families.
Packing tight Hamilton cycles in 3-uniform hypergraphs
Frieze, Alan; Loh, Po-Shen
2010-01-01
Let H be a 3-uniform hypergraph with N vertices. A tight Hamilton cycle C \\subset H is a collection of N edges for which there is an ordering of the vertices v_1, ..., v_N such that every triple of consecutive vertices {v_i, v_{i+1}, v_{i+2}} is an edge of C (indices are considered modulo N). We develop new techniques which enable us to prove that under certain natural pseudo-random conditions, almost all edges of H can be covered by edge-disjoint tight Hamilton cycles, for N divisible by 4. Consequently, we derive the corollary that random 3-uniform hypergraphs can be almost completely packed with tight Hamilton cycles w.h.p., for N divisible by 4 and P not too small. Along the way, we develop a similar result for packing Hamilton cycles in pseudo-random digraphs with even numbers of vertices.
THE RELAXING SCHEMES FOR HAMILTON-JACOBI EQUATIONS
Hua-zhong Tang; Hua-mu Wu
2001-01-01
Hamilton-Jacobiequation appears frequently in applications, e.g., in differential games and control theory, and is closely related to hyperbolic conservation laws[3, 4, 12]. This is helpful in the design of difference approximations for Hamilton-Jacobi equation and hyperbolic conservation laws. In this paper we present the relaxing system for HamiltonJacobiequations in arbitrary space dimensions, and high resolution relaxing schemes for Hamilton-Jacobi equation, based on using the local relaxation approximation. The schemes are numerically tested on a variety of 1D and 2D problems, including a problem related to optimal control problem. High-order accuracy in smooth regions, good resolution of discontinuities, and convergence to viscosity solutions are observed.
Hamilton Place - Ontario Canadá
Garwood-Jones, T. P.
1975-04-01
Full Text Available Although comparatively modest as to its exterior, the interior of the theatre-auditorium Hamilton Place has been most successfully solved, both as regards design and acoustics. Construction techniques and elements have been utilized to achieve two different sections in one and the same hall with on one hand the capacity to be able to capture shades of the spoken word at theatrical functions and on the other to reproduce the sharpness and variety of orchestras and choirs. The following elements deserve special mention: the mobile wall which incorporates the orchestra into the hall by closing the proscenium arch; the two elevating platforms where the orchestra is placed; the vertical velvet surfaces, hung like banners which soften the repercussion of the sound; the mobile horizontal surfaces over the orchestra that direct and orient the sound. The most interesting construction techniques are: the subdivision of the building into different parts, each one with independent foundation so as to avoid the transmission of the sound from one section to the other; the texture of the brick walls that disperse the reflected sound; and the use of counterforts to create smaller more personal sections for varied use. The acoustic characteristics are improved by means of a sound installation, formed by small loudspeakers placed under each seat and by other bigger ones distributed in the walls that surround the hall. The building is completed by various service installations that are appropriate to this type of construction, as well as by a small theatre-studio for the rehearsals of the orchestra and the actors, while other functions are going on in the main hall.El teatro-auditorio Hamilton Place, aunque relativamente modesto por fuera, tiene soluciones muy afortunadas en el interior, tanto por su diseño como por su adecuación acústica. Se han utilizado elementos y técnicas constructivas destinadas a conseguir, en una única sala, dos espacios
Hamilton Jeffers and the Double Star Catalogues
Tenn, Joseph S.
2013-01-01
Astronomers have long tracked double stars in efforts to find those that are gravitationally-bound binaries and then to determine their orbits. Court reporter and amateur astronomer Shelburne Wesley Burnham (1838-1921) published a massive double star catalogue containing more than 13,000 systems in 1906. The next keeper of the double stars was Lick Observatory astronomer Robert Grant Aitken (1864-1951), who produced a much larger catalogue in 1932. Aitken maintained and expanded Burnham’s records of observations on handwritten file cards, eventually turning them over to Lick Observatory astrometrist Hamilton Moore Jeffers (1893-1976). Jeffers further expanded the collection and put all the observations on punched cards. With the aid of Frances M. "Rete" Greeby (1921-2002), he made two catalogues: an Index Catalogue with basic data about each star, and a complete catalogue of observations, with one observation per punched card. He enlisted Willem van den Bos of Johannesburg to add southern stars, and they published the Index Catalogue of Visual Double Stars, 1961.0. As Jeffers approached retirement he became greatly concerned about the disposition of the catalogues. He wanted to be replaced by another "double star man," but Lick Director Albert E. Whitford (1905-2002) had the new 120-inch reflector, the world’s second largest telescope, and he wanted to pursue modern astrophysics instead. Jeffers was vociferously opposed to turning over the card files to another institution, and especially against their coming under the control of Kaj Strand of the U.S. Naval Observatory. In the end the USNO got the files and has maintained the records ever since, first under Charles Worley (1935-1997), and, since 1997, under Brian Mason. Now called the Washington Double Star Catalog (WDS), it is completely online and currently contains more than 1,000,000 measures of more than 100,000 pairs.
Geometric Hamilton-Jacobi theory on Nambu-Poisson manifolds
de León, M.; Sardón, C.
2017-03-01
The Hamilton-Jacobi theory is a formulation of classical mechanics equivalent to other formulations as Newtonian, Lagrangian, or Hamiltonian mechanics. The primordial observation of a geometric Hamilton-Jacobi theory is that if a Hamiltonian vector field XH can be projected into the configuration manifold by means of a 1-form dW, then the integral curves of the projected vector field XHd Wcan be transformed into integral curves of XH provided that W is a solution of the Hamilton-Jacobi equation. Our aim is to derive a geometric Hamilton-Jacobi theory for physical systems that are compatible with a Nambu-Poisson structure. For it, we study Lagrangian submanifolds of a Nambu-Poisson manifold and obtain explicitly an expression for a Hamilton-Jacobi equation on such a manifold. We apply our results to two interesting examples in the physics literature: the third-order Kummer-Schwarz equations and a system of n copies of a first-order differential Riccati equation. From the first example, we retrieve the original Nambu bracket in three dimensions and from the second example, we retrieve Takhtajan's generalization of the Nambu bracket to n dimensions.
Solution Hamilton-Jacobi equation for oscillator Caldirola-Kanai
LEONARDO PASTRANA ARTEAGA
2016-12-01
Full Text Available The method allows Hamilton-Jacobi explicitly determine the generating function from which is possible to derive a transformation that makes soluble Hamilton's equations. Using the separation of variables the partial differential equation of the first order called Hamilton-Jacobi equation is solved; as a particular case consider the oscillator Caldirola-Kanai (CK, which is characterized in that the mass presents a temporal evolution exponentially . We demonstrate that the oscillator CK position presents an exponential decay in time similar to that obtained in the damped sub-critical oscillator, which reflects the dissipation of total mechanical energy. We found that in the limit that the damping factor is small, the behavior is the same as an oscillator with simple harmonic motion, where the effects of energy dissipation is negligible.
Geometrical Field Theory of Hamilton Dynamic System In Rational Mechanics
Jianhua, Xiao
2011-01-01
When a set of particles are moving in a potential field, two aspects are concerned: 1) the relative motion of particle in spatial domain; 2) the particle velocity variations in time domain. The difficulty on treating the systems is originated from the fact that the motion in time domain and the motion in spatial domain are coupled together completely. Generally, for a Hamilton dynamic system established by a set of general velocity functions, several abstract theories have been well established, such as Lie algebra, Symplectic manifold, Poisson brackets, and others. However, mathematically, to find out a general Hamilton function is very difficult even for very simple problems. Inspired by these abstract mathematic researches, the Hamilton dynamic system is studied by geometrical field theory of deformation. Firstly, referring to the instant configuration, the deformation tensor in spatial domain and the velocity transformation tensor in time domain are established for a dynamic system defined by a set of gen...
Quantum Hamilton-Jacobi Cosmology and Classical-Quantum Correlation
Fathi, M.; Jalalzadeh, S.
2017-07-01
How the time evolution which is typical for classical cosmology emerges from quantum cosmology? The answer is not trivial because the Wheeler-DeWitt equation is time independent. A framework associating the quantum Hamilton-Jacobi to the minisuperspace cosmological models has been introduced in Fathi et al. (Eur. Phys. J. C 76, 527 2016). In this paper we show that time dependence and quantum-classical correspondence both arise naturally in the quantum Hamilton-Jacobi formalism of quantum mechanics, applied to quantum cosmology. We study the quantum Hamilton-Jacobi cosmology of spatially flat homogeneous and isotropic early universe whose matter content is a perfect fluid. The classical cosmology emerge around one Planck time where its linear size is around a few millimeter, without needing any classical inflationary phase afterwards to make it grow to its present size.
Russell, Anna Christine [Sandia National Laboratories (SNL-CA), Livermore, CA (United States)
2014-09-01
Throughout my HS-STEM internship, I worked on two different projects with a systems analysis group at Sandia National Laboratories in Livermore, California (SNLCA). The first, and primary, project entailed building a conceptual model of health surveillance detection of a bioterror attack. The second project was much smaller in scope and looked at cost tradeoffs between volumetric and surface decontamination after the release of anthrax in a city. Both projects helped me to understand the challenges of planning for a bioterror attack and the importance of preparedness in the public health sector.
the doubly magic nucleus 270Hs
Silisteanu I.
2016-01-01
Full Text Available The α-decay and spontaneous fission half-lives of nuclei around 270Hs are calculated with formulas derived from an in-depth analysis of the available experimental data and of results of theoretical models. The parameters of these formulas result from the fit of half-lives with respect to the reaction energies, the height of the SF barrier and the fissionability. The calculated partial and total half-lives are compared with the experimental data and results of other approximations. Half-life predictions are made for many unknown nuclei.
A Quantum Algorithm for Finding a Hamilton Circuit
GUO Hao; LONG Gui-Lu; SUN Yang; XIU Xiao-Lin
2001-01-01
A quantum algorithm for solving the classical NP-complete problem - the Hamilton circuit is presented. The algorithm employs the quantum SAT and the quantum search algorithms. The algorithm is square-root faster than classical algorithm, and becomes exponentially faster than classical algorithm if nonlinear quantum mechanical computer is used.
Hamilton´s Principle and Electric Circuits Tudory
Daniel Mayer
2006-01-01
Full Text Available In the theory of electrical or electromechanical circuits different methods are known for construction of mathematical model. In this paper another, alternative method is introduced that is based on Hamilton variational principle that is generally valid in physics.
Spin Hamilton Operators, Symmetry Breaking, Energy Level Crossing and Entanglement
Steeb, Willi-Hans; Hardy, Yorick; de Greef, Jacqueline
2011-01-01
We study finite-dimensional product Hilbert spaces, coupled spin systems, entanglement and energy level crossing. The Hamilton operators are based on the Pauli group. We show that swapping the interacting term can lead from unentangled eigenstates to entangled eigenstates and from an energy spectrum with energy level crossing to avoided energy level crossing.
Numerical Solution of Hamilton-Jacobi Equations in High Dimension
2012-11-23
high dimension FA9550-10-1-0029 Maurizio Falcone Dipartimento di Matematica SAPIENZA-Universita di Roma P. Aldo Moro, 2 00185 ROMA AH930...solution of Hamilton-Jacobi equations in high dimension AFOSR contract n. FA9550-10-1-0029 Maurizio Falcone Dipartimento di Matematica SAPIENZA
Hojman Exact Invariants and Adiabatic Invariants of Hamilton System
无
2007-01-01
The perturbation to Lie symmetry and adiabatic invariants are studied. Based on the concept of higherorder adiabatic invariants of mechanical systems with action of a small perturbation, the perturbation to Lie symmetry is studied, and Hojman adiabatic invariants of Hamilton system are obtained. An example is given to illustrate the application of the results.
Hamilton,Sir William Rowan(1805-1865)
2002-01-01
Shortly after Hamilton submitted his paper and while still an undergraduate,Trinity College elected him to the post of Andrews professor of astronomy and royal astronomer of Ireland’ to succeed Brinkley,who had been made a bishop. Thus an undergraduate(not quite 22years old) became ex officio an examiner of graduates who were candidates
Whittaker方程的Hamilton化%Hamiltonization of Whittaker equations
丁光涛
2010-01-01
引入Whittaker方程的Birkhoff表示,构造与该表示对应的Hamilton函数,并利用Hamilton-Poisson方法得到Whittaker方程的解.指出上述Hamilton函数与传统分析力学中Hamilton函数的区别.
Unconventional Hamilton-type variational principles for analytical mechanics
2007-01-01
According to the basic idea of classical yin-yang complementarity and modern dual-complementarity, in a simple and unified new way proposed by Luo, the un-conventional Hamilton-type variational principles of holonomic conservative system in analytical mechanics can be established systematically. This unconventional Hamilton-type variational principle can fully characterize the initial-value problem of analytical mechanics, so that it is an important innovation for the Hamilton-type variational principle. In this paper, an important integral relation is given, which can be considered as the expression of the generalized principle of virtual work for analytical mechanics in mechanics. Based on this relation, it is possible not only to obtain the principle of virtual work of holonomic conservative system in analytical mechanics, but also to derive systematically the complementary functionals for three-field and two-field unconventional variational principles, and the functional for the one-field one by the generalized Legendre transformation given in this paper. Further, with this new approach, the intrinsic relationship among various principles can be explained clearly. Meanwhile, the unconventional Hamilton-type variational principles of nonholonomic conservative system in analytical mechanics can also be established systematically in this paper.
Unconventional Hamilton-type variational principles for analytical mechanics
LUO En; LIANG LiFu; LI WeiHua
2007-01-01
According to the basic idea of classical yin-yang complementarity and modern dual-complementarity, in a simple and unified new way proposed by Luo, the unconventional Hamilton-type variational principles of holonomic conservative system in analytical mechanics can be established systematically. This unconventional Hamilton-type variational principle can fully characterize the initial-value problem of analytical mechanics, so that it is an important innovation for the Hamilton-type variational principle. In this paper, an important integral relation is given, which can be considered as the expression of the generalized principle of virtual work for analytical mechanics in mechanics. Based on this relation, it is possible not only to obtain the principle of virtual work of holonomic conservative system in analytical mechanics, but also to derive systematically the complementary functionals for three-field and two-field unconventional variational principles, and the functional for the one-field one by the generalized Legendre transformation given in this paper. Further, with this new approach, the intrinsic relationship among various principles can be explained clearly. Meanwhile, the unconventional Hamilton-type variational principles of nonholonomic conservative system in analytical mechanics can also be established systematically in this paper.
Unconventional Hamilton-type variational principles for electromagnetic elastodynamics
无
2006-01-01
According to the basic idea of classical yin-yang complementarity and modern dual-complementarity, in a simple and unified new way proposed by Luo, the unconventional Hamilton-type variational principles for electromagnetic elastodynamics can be established systematically. This new variational principles can fully characterize the initial-boundary-value problem of this dynamics. In this paper, the expression of the generalized principle of virtual work for electromagnetic dynamics is given. Based on this equation, it is possible not only to obtain the principle of virtual work in electromagnetic dynamics, but also to derive systematically the complementary functionals for eleven-field, nine-field and six-field unconventional Hamilton-type variational principles for electromagnetic elastodynamics, and the potential energy functionals for four-field and three-field ones by the generalized Legendre transformation given in this paper. Furthermore, with this approach, the intrinsic relationship among various principles can be explained clearly.
Beam dynamics with the Hamilton-Jacobi equation
Gabella, W.E.; Ruth, R.D.; Warnock, R.L.
1989-03-01
We describe a non-perturbative method to solve the Hamilton-Jacobi equation for invariant surfaces in phase space. The problem is formulated in action-angle variables with a general nonlinear perturbation. The solution of the Hamilton-Jacobi equation is regarded as the fixed point of a map on the Fourier coefficients of the generating function. Periodicity of the generator in the independent variable is enforced with a shooting method. We present two methods for finding the fixed point and hence the invariant surface. A solution by plain iteration is economical but has a restricted domain of convergence. The Newton iteration is costly but yields solutions up to the dynamic aperture. Examples of lattices with sextupoles for chromatic correction are discussed. 10 refs., 5 figs., 1 tab.
Studying on Opinion Evolution by Hamilton-Jacobi Equation
Feng, Chen-Jie; Huo, Jie; Hao, Rui; Wang, Xu-Ming
2016-01-01
A physical description of an opinion evolution is conducted based on the Hamilton-Jacobi equation derived from a generalized potential and the corresponding Langevin equation. The investigation mainly focuses on the heterogeneities such as age, connection circle and overall quality of the participants involved in the opinion exchange process. The evolutionary patterns of opinion can be described by solution of the Hamilton-Jacobi equation, information entropy. The results show that the overall qualities of the participants play critical roles in forming an opinion. The higher the overall quality is, the easier the consensus can reach. The solution also demonstrates that the age and the connection circle of the agents play equally important roles in forming an opinion. The essence of the age, overall quality, and connection circle corresponds to the maturity of thought (opinion inertia), reason and intelligence, influence strength of the environment, respectively. So the information entropy distributes in the ...
Hamilton geometry: Phase space geometry from modified dispersion relations
Barcaroli, Leonardo; Gubitosi, Giulia; Loret, Niccoló; Pfeifer, Christian
2015-01-01
We describe the Hamilton geometry of the phase space of particles whose motion is characterised by general dispersion relations. In this framework spacetime and momentum space are naturally curved and intertwined, allowing for a simultaneous description of both spacetime curvature and non-trivial momentum space geometry. We consider as explicit examples two models for Planck-scale modified dispersion relations, inspired from the $q$-de Sitter and $\\kappa$-Poincar\\'e quantum groups. In the first case we find the expressions for the momentum and position dependent curvature of spacetime and momentum space, while for the second case the manifold is flat and only the momentum space possesses a nonzero, momentum dependent curvature. In contrast, for a dispersion relation that is induced by a spacetime metric, as in General Relativity, the Hamilton geometry yields a flat momentum space and the usual curved spacetime geometry with only position dependent geometric objects.
Hamilton-Jacobi formalism of tachyon inflation and cosmological perturbations
LIU Daojun
2014-08-01
Full Text Available We study the cosmological inflation models driven by the rolling tachyon field which has a Born-Infeld-type action.We drive the Hamilton-Jacobi equation for the cosmological dynamics of tachyon inflation and the mode equations for the scalar and tensor perturbations of tachyon field and spacetime, then a solution under the slow-roll condition is given. In the end,a realistic model from string theory is discussed.
Sir William Rowan Hamilton: Life, Achievements, Stature in Physics
2016-06-01
Against the background of the development ofphysics, and in particular of mechanics, over thecenturies since Galileo and Newton, we describethe life and work of William Rowan Hamilton inthe 19th century. The depth of his ideas whichbrought together the understanding of ray opticsand classical mechanics, and the remarkableways in which his work paved the way to theconstruction of quantum mechanics in the 20thcentury, are emphasized.
Wave-Particle Duality and the Hamilton-Jacobi Equation
Sivashinsky, Gregory I
2009-01-01
The Hamilton-Jacobi equation of relativistic quantum mechanics is revisited. The equation is shown to permit solutions in the form of breathers (oscillating/spinning solitons), displaying simultaneous particle-like and wave-like behavior. The de Broglie wave thus acquires a clear deterministic meaning of a wave-like excitation of the classical action function. The problem of quantization in terms of the breathing action function and the double-slit experiment are discussed.
Hamilton,Sir William Rowan(1805-1865)
2002-01-01
Irish mathematician and astronomer who developed the theory of quaternions, a landmark in the development of algebra,and discovered the phenomenon of conical refraction. His unification of dynamics and optics,moreover,has had alasting influence on mathematical physics, even though the full significance of his work was not fully appreciated until after the risd of quantum mechanics. Like his English contemporaries Thomas Babington Macaulay and John Stuart Mill,Hamilton showed
Conformal invariance and Hojman conserved quantities of canonical Hamilton systems
Liu Chang; Liu Shi-Xing; Mei Feng-Xiang; Guo Yong-Xin
2009-01-01
This paper discusses the conformal invariance by infinitesimal transformations of canonical Hamilton systems. The necessary and sufficient conditions of conformal invariance being Lie symmetrical simultaneously by the action of infinitesimal transformations are given. The determining equations of the conformal invariance are gained. Then the Hojman conserved quantities of conformal invariance by special infinitesimal transformations are obtained. Finally an illustrative example is given to verify the results.
Hamilton-Jacobi method for a simple resonance
Rudnev, Mischa
2003-01-01
It is well known that a generic small perturbation of a Liouville-integrable Hamiltonian system causes breakup of resonant and near-resonant invariant tori. A general approach to the simple resonance case in the convex real-analytic setting is developed, based on a new technique for solving the Hamilton-Jacobi equation. It is shown that a generic perturbation creates in the core of a resonance a partially hyperbolic lower-dimensional invariant torus, whose Lagrangian stable and unstable manif...
Kinetic derivation of a Hamilton-Jacobi traffic flow model
Borsche, Raul; Kimathi, Mark
2012-01-01
Kinetic models for vehicular traffic are reviewed and considered from the point of view of deriving macroscopic equations. A derivation of the associated macroscopic traffic flow equations leads to different types of equations: in certain situations modified Aw-Rascle equations are obtained. On the other hand, for several choices of kinetic parameters new Hamilton-Jacobi type traffic equations are found. Associated microscopic models are discussed and numerical experiments are presented discussing several situations for highway traffic and comparing the different models.
Unconventional Hamilton-type variational principles for nonlinear coupled thermoelastodynamics
罗恩; 邝君尚; 黄伟江; 罗志国
2002-01-01
According to the basic idea of classical yin-yang complementarity and modem dual-com plementarity, in a simple and unified new way proposed by Luo, the unconventional Hamilton-type vari ational principles for geometrically nonlinear coupled thermoelastodynamics can be established system atically. The new unconventional Hamilton-type variational principle can fully characterize the initia boundary-value problem of this dynamics. In this paper, an important integral relation is given, which can be considered as the expression of the generalized principle of virtual work for geometrically nonlin ear coupled thermodynamics. Based on this relation, it is possible not only to obtain the principle of vir tual work in geometrically nonlinear coupled thermodynamics, but also to derive systematically the complementary functionals for eight-field, six-field, four-field and two-field unconventional Hamilton type variational principles by the generalized Legendre transformations given in this paper. Further more, with this approach, the intrinsic relationship among various principles can be explained clearly.
Occupational Accident Declaration Form (HS50)
HR Department
2007-01-01
https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under the occupational scheme in the event of cure (defined in § 15 as the certified end to the impairment of the patient’s state of health caused by the illness or accident), or consolidation (defined in § 14 as certification that no further improvement in the patient’s state of health can be expected from appropriate medical treatment). The right to such reimbursement shall resume only in the...
Analysis of the HI-6, HS-3 and HS-6, Influence on the Liver Methabolizing Enzyme Systems
2001-09-01
ON THE LIVER METHABOLIZING ENZIME SYSTEMS Christophor Dishovsky, Maria Kadiiska*, Petko Alov* Military Medical Academy, 1606, Sofia, Bulgaria...reactivators of ChE, liver, methabolizing enzime systems FIGURES AND TABLES Table 1. Effect of reactivators of ChE HS-3, HS-6, HI-6 on the hexobarbital
Hansen, Jesper Bent; Bech, Per
2011-01-01
-reporting versions (definitely and semidefinitely anchored) corresponding to the Hamilton Depression Scale (HAMD), the Hamilton Subscale (HAM6), and the Bech-Rafaelsen Melancholia Scale (MES) were compared to each other and the clinician-rated version. The unidimensional property of the sum score in each scale...
National Aeronautics and Space Administration — ITN Energy Systems, Inc., in collaboration with Hamilton Sundstrand, proposes to design and develop multifunctional fibers for use in energy generation, energy...
Nuclear power and the Hamilton-Jefferson debate
Hacker, A.
The basic sources of nuclear opposition derive from the philosophical arguments of Thomas Jefferson against Alexander Hamilton's vision of an industrial society with a strong central authority. Today's young people continue Jefferson's radical plea for the individual freedoms associated with personal ownership and limited government, but they accept the structure of the former while searching for the romanticism of the latter. The nuclear debate reflects this dichotomy and will continue even if the issues of waste disposal and safety are resolved. (DCK)
Multimodal electromechanical model of piezoelectric transformers by Hamilton's principle.
Nadal, Clement; Pigache, Francois
2009-11-01
This work deals with a general energetic approach to establish an accurate electromechanical model of a piezoelectric transformer (PT). Hamilton's principle is used to obtain the equations of motion for free vibrations. The modal characteristics (mass, stiffness, primary and secondary electromechanical conversion factors) are also deduced. Then, to illustrate this general electromechanical method, the variational principle is applied to both homogeneous and nonhomogeneous Rosen-type PT models. A comparison of modal parameters, mechanical displacements, and electrical potentials are presented for both models. Finally, the validity of the electrodynamical model of nonhomogeneous Rosen-type PT is confirmed by a numerical comparison based on a finite elements method and an experimental identification.
DISCONTINUOUS SOLUTIONS IN L∞ FOR HAMILTON-JACOBI EQUATIONS
无
2000-01-01
An approach is introduced to construct global discontinuous solutions in L∞ for Hamilton Jacobi equations. This approach allows the initial data only in L∞ and applies to the equations with nonconvex Hamiltonians. The profit functions are introduced to formulate the notion of discontinuous solutions in L. The existence of global discontinuous solutions in L∞ is established. These solutions in L∞ coincide with the viscosity solutions and the minimax solutions, provided that the initial data are continuous. A prototypical equation is analyzed to examine the L∞ stability of our L∞ solutions. The analysis also shows that global discontinuous solutions are determined by the topology in which the initial data are approximated.
Hamilton-Jacobi method for curved domain walls and cosmologies
Skenderis, Kostas; Townsend, Paul K.
2006-12-01
We use Hamiltonian methods to study curved domain walls and cosmologies. This leads naturally to first-order equations for all domain walls and cosmologies foliated by slices of maximal symmetry. For Minkowski and AdS-sliced domain walls (flat and closed FLRW cosmologies) we recover a recent result concerning their (pseudo)supersymmetry. We show how domain-wall stability is consistent with the instability of AdS vacua that violate the Breitenlohner-Freedman bound. We also explore the relationship to Hamilton-Jacobi theory and compute the wave-function of a 3-dimensional closed universe evolving towards de Sitter spacetime.
The Hamilton-Jacobi method and Hamiltonian maps
Abdullaev, S.S. [Institut fuer Plasmaphysik, Forschungszentrum Juelich GmbH, EURATOM Association, Trilateral Euregio Cluster, Juelich (Germany)
2002-03-29
A method for constructing time-step-based symplectic maps for a generic Hamiltonian system subjected to perturbation is developed. Using the Hamilton-Jacobi method and Jacobi's theorem in finite periodic time intervals, the general form of the symplectic maps is established. The generating function of the map is found by the perturbation method in the finite time intervals. The accuracy of the maps is studied for fully integrable and partially chaotic Hamiltonian systems and compared to that of the symplectic integration method. (author)
The Hamilton-Jacobi method and Hamiltonian maps
Abdullaev, S. S.
2002-03-01
A method for constructing time-step-based symplectic maps for a generic Hamiltonian system subjected to perturbation is developed. Using the Hamilton-Jacobi method and Jacobi's theorem in finite periodic time intervals, the general form of the symplectic maps is established. The generating function of the map is found by the perturbation method in the finite time intervals. The accuracy of the maps is studied for fully integrable and partially chaotic Hamiltonian systems and compared to that of the symplectic integration method.
Hamilton and Hardy for the 21st Century
Ogden, Trevor
2016-01-01
Hamilton and Hardy’s Industrial Toxicology is now 80 years old, and the new sixth edition links us with a pioneer era. This is an impressive book, but the usefulness of the hardback version as a reference book is unfortunately limited by its poor index. There is now an ebook version, and for the practitioner on the move this has the great advantages of searchability and portability. However, Wiley ebooks can apparently only be downloaded when first purchased, so their lifetime is limited to that of the device. The Kindle edition should avoid this shortcoming.
Intralesional triamcinolone for flares of hidradenitis suppurativa (HS)
Riis, Peter Theut; Boer, Jurr; Prens, Errol P
2016-01-01
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Standard practice of managing acute flares with corticosteroid injection lacks scientific evidence. OBJECTIVE: We sought to assess the outcomes of routine treatment using intralesional triamcinolone...
Fast methods for static Hamilton-Jacobi Partial Differential Equations
Vladimirsky, Alexander Boris
2001-05-01
The authors develop a family of fast methods approximating the solution to a wide class of static Hamilton-Jacobi partial differential equations. These partial differential equations are considered in the context of control-theoretic and front-propagation problems. In general, to produce a numerical solution to such a problem, one has to solve a large system of coupled non-linear discretized equations. The techniques use partial information about the characteristic directions to de-couple the system. Previously known fast methods, available for isotropic problems, are discussed in detail. They introduce a family of new Ordered Upwinding Methods (OUM) for general (anisotropic) problems and prove convergence to the viscosity solution of the corresponding Hamilton-Jacobi partial differential equation. The hybrid methods introduced here are based on the analysis of the role played by anisotropy in the context of front propagation and optimal trajectory problems. The performance of the methods is analyzed and compared to that of several other numerical approaches to these problems. Computational experiments are performed using test problems from control theory, computational geometry and seismology.
A hybrid-stress element based on Hamilton principle
Cen, Song; Zhang, Tao; Li, Chen-Feng; Fu, Xiang-Rong; Long, Yu-Qiu
2010-08-01
A novel hybrid-stress finite element method is proposed for constructing simple 4-node quadrilateral plane elements, and the new element is denoted as HH4-3 β here. Firstly, the theoretical basis of the traditional hybrid-stress elements, i.e., the Hellinger-Reissner variational principle, is replaced by the Hamilton variational principle, in which the number of the stress variables is reduced from 3 to 2. Secondly, three stress parameters and corresponding trial functions are introduced into the system equations. Thirdly, the displacement fields of the conventional bilinear isoparametric element are employed in the new models. Finally, from the stationary condition, the stress parameters can be expressed in terms of the displacement parameters, and thus the new element stiffness matrices can be obtained. Since the required number of stress variables in the Hamilton variational principle is less than that in the Hellinger-Reissner variational principle, and no additional incompatible displacement modes are considered, the new hybrid-stress element is simpler than the traditional ones. Furthermore, in order to improve the accuracy of the stress solutions, two enhanced post-processing schemes are also proposed for element HH4-3 β. Numerical examples show that the proposed model exhibits great improvements in both displacement and stress solutions, implying that the proposed technique is an effective way for developing simple finite element models with high performance.
Fast methods for static Hamilton-Jacobi Partial Differential Equations
Vladimirsky, Alexander Boris [Univ. of California, Berkeley, CA (United States)
2001-01-01
The authors develop a family of fast methods approximating the solution to a wide class of static Hamilton-Jacobi partial differential equations. These partial differential equations are considered in the context of control-theoretic and front-propagation problems. In general, to produce a numerical solution to such a problem, one has to solve a large system of coupled non-linear discretized equations. The techniques use partial information about the characteristic directions to de-couple the system. Previously known fast methods, available for isotropic problems, are discussed in detail. They introduce a family of new Ordered Upwinding Methods (OUM) for general (anisotropic) problems and prove convergence to the viscosity solution of the corresponding Hamilton-Jacobi partial differential equation. The hybrid methods introduced here are based on the analysis of the role played by anisotropy in the context of front propagation and optimal trajectory problems. The performance of the methods is analyzed and compared to that of several other numerical approaches to these problems. Computational experiments are performed using test problems from control theory, computational geometry and seismology.
Deckers, Inge E.; Janse, Ineke C.; van der Zee, Hessel H.; Nijsten, Tamar; Boer, Jurr; Horvath, Barbara; Prens, Errol P.
2016-01-01
Background: Hidradenitis suppurativa (HS) is a chronic debilitating disease, whereby school attendance and employment can be disturbed. Objective: We sought to determine the socioeconomic status (SES) in patients with HS relative to other dermatologic patients, and whether specific clinical HS
Unconditionally stable methods for Hamilton-Jacobi equations
Karlsen, Kenneth Hvistendal; Risebro, Nils Henrik
2000-05-01
We present new numerical methods for constructing approximate solutions to the Cauchy problem for Hamilton-Jacobi equations of the form u{sub t} + H(D{sub x}u) = 0. The methods are based on dimensional splitting and front tracking for solving the associated (non-strictly hyperbolic) system of conservation laws p{sub t} + D{sub x}H(p) = 0, where p = D{sub x}u. In particular, our methods depend heavily on a front tracking method for one-dimensional scalar conservation laws with discontinuous coefficients. The proposed methods are unconditionally stable in the sense that the time step is not limited by the space discretization and they can be viewed as ''large time step'' Godunov type (or front tracking) methods. We present several numerical examples illustrating the main features of the proposed methods. We also compare our methods with several methods from the literature. (author)
The Hamilton principle for fluid binary mixtures with two temperatures
Gouin, Henri
2009-01-01
For binary mixtures of fluids without chemical reactions, but with components having different temperatures, the Hamilton principle of least action is able to produce the equation of motion for each component and a balance equation of the total heat exchange between components. In this nonconservative case, a Gibbs dynamical identity connecting the equations of momenta, masses, energy and heat exchange allows to deduce the balance equation of energy of the mixture. Due to the unknown exchange of heat between components, the number of obtained equations is less than the number of field variables. The second law of thermodynamics constrains the possible expression of a supplementary constitutive equation closing the system of equations. The exchange of energy between components produces an increasing rate of entropy and creates a dynamical pressure term associated with the difference of temperature between components. This new dynamical pressure term fits with the results obtained by classical thermodynamical a...
Surface Modification of ZnO Nanorods with Hamilton Receptors
Lukas Zeininger
2015-04-01
Full Text Available A new prototype of a Hamilton receptor suitable for the functionalization of inorganic nanoparticles was synthesized and characterized. The hydrogen bonding receptor was coupled to a catechol moiety, which served as anchor group for the functionalization of metal oxides, in particular zinc oxide. Synthesized zinc oxide nanorods [ZnO] were used for surface functionalization. The wet-chemical functionalization procedure towards monolayer-grafted particles [ZnO-HR] is described and a detailed characterization study is presented. In addition, the detection of specific cyanurate molecules is demonstrated. The hybrid structures [ZnO-HR-CA] were stable towards agglomeration and exhibited enhanced dispersability in apolar solvents. This observation, in combination with several spectroscopic experiments gave evidence of the highly directional supramolecular recognition at the surface of nanoparticles.
Geometric Hamilton-Jacobi theory for higher-order autonomous systems
Colombo, Leonardo; de León, Manuel; Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso
2014-06-01
The geometric framework for the Hamilton-Jacobi theory is used to study this theory in the background of higher-order mechanical systems, in both the Lagrangian and Hamiltonian formalisms. Thus, we state the corresponding Hamilton-Jacobi equations in these formalisms and apply our results to analyze some particular physical examples.
Sense of Belonging and Mental Health in Hamilton, Ontario: An Intra-Urban Analysis
Kitchen, Peter; Williams, Allison; Chowhan, James
2012-01-01
This paper examines geographic variations in sense of community belonging in Hamilton, Ontario. It also identifies the most significant health and social factors associated with belonging in the city. The research employs data from the 2007/08 Canadian Community Health Survey for respondents aged 18 or over living in the Hamilton Census…
Hogue, Ross W; Feltham, Humphrey L C; Miller, Reece G; Brooker, Sally
2016-05-01
Access to a new family of thioether-linked PSRT ligands, 4-substituted-3,5-bis{[(2-pyridylmethyl)sulfanyl]methyl}-4H-1,2,4-triazoles (analogues of the previously studied amino-linked PMRT ligands), has been established. Four such ligands have been prepared, PSPhT, PS(i)BuT, PS(t-Bu)PhT, and PS(Me)PhT, with R = Ph, (i)Bu, (t-Bu)Ph, and (Me)Ph, respectively. Three dinuclear colorless to pale green iron(II) complexes, [Fe(II)2(PSRT)2](BF4)4·solvent, featuring N4S2 donor sets, were prepared. Single-crystal structure determinations on [Fe(II)2(PSPhT)2](BF4)4·2MeCN·H2O, [Fe(II)2(PSPhT)2](BF4)4·2(1)/2MeCN·(1)/2H2O·THF, [Fe(II)2(PS(Me)PhT)2](BF4)4·2MeCN, and [Fe(II)2(PS(i)BuT)2](BF4)4·4MeCN reveal that all four are stabilized in the [HS-HS] state to 100 K and that both possible binding modes of the bis-terdentate ligands, cis- and trans-axial, are observed. Variable-temperature magnetic susceptibility studies of air-dried crystals (solvatomorphs of the single crystal samples) reveal the first examples of spin crossover (SCO) for a dinuclear iron(II) complex with N4S2 coordination. Specifically, [Fe(II)2(PSPhT)2](BF4)4·2(1)/2H2O undergoes a multistep but complete SCO from [HS-HS] to [LS-LS], whereas [Fe(II)2(PS(Me)PhT)2](BF4)4·1(1)/2MeCN·2H2O exhibits a half-SCO from [HS-HS] to [HS-LS]. In contrast, [Fe(II)2(PS(i)BuT)2](BF4)4·MeCN·H2O remains [HS-HS] down to 50 K. The reflectance spectrum of pale green [Fe(II)2(PSPhT)2](BF4)4·(1)/2CHCl3·2(1)/2H2O (solvatomorph A) reveals a trace of LS character (572 nm band (1)A1g → (1)T1g). Evans' (1)H NMR method and UV-vis spectroscopy studies revealed that on cooling dark green acetonitrile solutions of these complexes from 313 to 233 K, all three undergo SCO centered at or near room temperature. The tendency of the complexes to go LS in solution reflects the electronic impact of R on the σ-donor strength of the PSRT ligand, whereas the opposite trend in stabilization of the LS state is seen in the solid state, where
Saroj K. Ghosh
2015-05-01
Full Text Available The histological features and histochemical characterization of the stomach were investigated in Mystus cavasius (Hamilton, Oreochromis niloticus (Linnaeus and Gudusia chapra (Hamilton having different feeding habits. Histologically the stomach of all the three fishes was made up of mucosa, submucosa, muscularis and serosa. The mucosa of superficial epithelium consists of a single layer of compactly arranged columnar epithelial cells. Prominent gastric glands are present in M. cavasius whereas in G. chapra the gastric glands are totally absent in the gizzard like stomach. However, in O. niloticus tubular gastric glands are present in the glandular epithelium of caecal like stomach. The distribution and chemical nature of mucopolysaccharides in the aforementioned fishes were studied histochemically by employing Periodic Acid Schiff’s in combination with the Alcian Blue (PAS–AB technique. Columnar epithelial cells lining the mucosa of the stomach including mucosal border were provided with exclusively neutral mucin which was probably involved in the protective functions against acid and enzymes. The different intensities of reaction of Best Carmine (BC for glycogen in the epithelial lining and gastric glands of the stomach of the aforesaid three fish species under study were discussed. The intense reaction for protein and tryptophan was noticed in the gastric epithelium and gastric glands of M. cavasius probably due to accumulation of zymogen granules in the gastric glands. On the contrary, moderate reaction for protein and tryptophan was associated with the epithelial cells and gastric glands of O. niloticus and G. chapra. The cytoarchitecture and different degrees of localization of mucopolysaccharides, glycogen, protein and tryptophan in the stomach of M. cavasius, O. niloticus and G. chapra were correlated with the functional significance of the region concerned.
Developing competitive marketing and sales strategy for HS-Eden
Dragusha, Cajup
2016-01-01
Start-ups are faced with variety of challenges and uncertainty therefore comprehensive marketing and sales strategy must be in place to make sure that limited resources are spend wisely in order to minimize uncertainty and pave a path that would lead to successful business. HS Eden is a new-start-up venture created in Lappeenranta University of Technology with an ambition to develop AMB systems for commercial use. The aim of this study was to build a marketing and sales strategy to help HS-Ed...
无向完全图的哈密顿回路%Hamilton Circles of No Direction Graph
梁震; 陈新军
2000-01-01
In this article,a way of finding all Hamilton cycles of a perfect no direction graph will be presented.Then we can find out the formula of all Hamilton circles of a perfect no direction graph.Finally the way will be expanded to other cases like finding whether a graph has Hamilton cycles or not.
The fate of Hamilton's Hodograph in Special and General Relativity
Gibbons, G W
2015-01-01
The hodograph of a non-relativistic particle motion in Euclidean space is the curve described by its momentum vector. For a general central orbit problem the hodograph is the inverse of the pedal curve of the orbit, (i.e. its polar reciprocal), rotated through a right angle. Hamilton showed that for the Kepler/Coulomb problem, the hodograph is a circle whose centre is in the direction of a conserved eccentricity vector. The addition of an inverse cube law force induces the eccentricity vector to precess and with it the hodograph. The same effect is produced by a cosmic string. If one takes the relativistic momentum to define the hodograph, then for the Sommerfeld (i.e. the special relativistic Kepler/Coulomb problem) there is an effective inverse cube force which causes the hodograph to precess. If one uses Schwarzschild coordinates one may also define a a hodograph for timelike or null geodesics moving around a black hole. Iheir pedal equations are given. In special cases the hodograph may be found explicitl...
Singular Hamilton-Jacobi equation for the tail problem
Mirrahimi, Sepideh; Perthame, Benoit; Souganidis, Panagiotis E
2010-01-01
In this paper we study the long time-long range behavior of reaction diffusion equations with negative square root -type reaction terms. In particular we investigate the exponential behavior of the solutions after a standard hyperbolic scaling. This leads to a Hamilton-Jacobi variational inequality with an obstacle that depends on the solution itself and defines the open set where the limiting solution does not vanish. Counter-examples show a nontrivial lack of uniqueness for the variational inequality depending on the conditions imposed on the boundary of this open set. Both Dirichlet and state constraints boundary conditions play a role. When the competition term does not change sign, we can identify the limit, while, in general, we find lower and upper bounds for the limit. Although models of this type are rather old and extinction phenomena are as important as blow-up, our motivation comes from the so-called "tail problem" in population biology. One way to avoid meaningless exponential tails, is to impose...
Hamilton's equations for a fluid membrane
Capovilla, R [Departamento de Fisica, Centro de Investigacion y de Estudios Avanzados, Apdo. Postal 14-740, 07000 Mexico, DF (Mexico); Guven, J [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Apdo. Postal 70-543, 04510 Mexico, DF (Mexico); Rojas, E [Facultad de Fisica e Inteligencia Artificial, Universidad Veracruzana, 91000 Xalapa, Veracruz (Mexico)
2005-10-14
Consider a homogeneous fluid membrane described by the Helfrich-Canham energy, quadratic in the mean curvature of the membrane surface. The shape equation that determines equilibrium configurations is fourth order in derivatives and cubic in the mean curvature. We introduce a Hamiltonian formulation of this equation which dismantles it into a set of coupled first-order equations. This involves interpreting the Helfrich-Canham energy as an action; equilibrium surfaces are generated by the evolution of space curves. Two features complicate the implementation of a Hamiltonian framework. (i) The action involves second derivatives. This requires treating the velocity as a phase-space variable and the introduction of its conjugate momentum. The canonical Hamiltonian is constructed on this phase space. (ii) The action possesses a local symmetry-reparametrization invariance. The two labels we use to parametrize points on the surface are themselves physically irrelevant. This symmetry implies primary constraints, one for each label, that need to be implemented within the Hamiltonian. The two Lagrange multipliers associated with these constraints are identified as the components of the acceleration tangential to the surface. The conservation of the primary constraints implies two secondary constraints, fixing the tangential components of the momentum conjugate to the position. Hamilton's equations are derived and the appropriate initial conditions on the phase-space variables are identified. Finally, it is shown how the shape equation can be reconstructed from these equations.
Quantitative Compactness Estimates for Hamilton-Jacobi Equations
Ancona, Fabio; Cannarsa, Piermarco; Nguyen, Khai T.
2016-02-01
We study quantitative compactness estimates in {W^{1,1}_{loc}} for the map {S_t}, {t > 0} that is associated with the given initial data {u_0in Lip (R^N)} for the corresponding solution {S_t u_0} of a Hamilton-Jacobi equation u_t+Hbig(nabla_{x} ubig)=0, qquad t≥ 0,quad xinR^N, with a uniformly convex Hamiltonian {H=H(p)}. We provide upper and lower estimates of order {1/\\varepsilon^N} on the Kolmogorov {\\varepsilon}-entropy in {W^{1,1}} of the image through the map S t of sets of bounded, compactly supported initial data. Estimates of this type are inspired by a question posed by Lax (Course on Hyperbolic Systems of Conservation Laws. XXVII Scuola Estiva di Fisica Matematica, Ravello, 2002) within the context of conservation laws, and could provide a measure of the order of "resolution" of a numerical method implemented for this equation.
The Hamilton depression scale. Evaluation of objectivity using logistic models.
Bech, P; Allerup, P; Gram, L F; Reisby, N; Rosenberg, R; Jacobsen, O; Nagy, A
1981-03-01
The consistency of the Hamilton Depression Scale (HDS) as a measure of the severity of depressive states has been examined when the scale was used weekly during a trial when imipramine. By use of logistic models (Rasch) the consistency of the HDS has been considered across patient-variables as age, sex, plasma levels of imipramine, and diagnosis. The results showed that the original 17-item HDS was without adequate consistency, i.e. the total score of the sample of items was no one-dimensional measure of depressive states. However, a melancholia subscale of the HDS contained items the total of which can be used to compare patients quantitatively, although in some part of the analysis one of these items showed ceiling effect. It was concluded that the melancholia subscale (containing the items depressed mood, guilt, work and interests, retardation, psychic anxiety, and general somatic symptoms) can form the basis for further improvements in the field of quantitative rating scales for depressive states.
An electromechanical model of neuronal dynamics using Hamilton's principle
Drapaca, Corina S.
2015-01-01
Damage of the brain may be caused by mechanical loads such as penetration, blunt force, shock loading from blast, and by chemical imbalances due to neurological diseases and aging that trigger not only neuronal degeneration but also changes in the mechanical properties of brain tissue. An understanding of the interconnected nature of the electro-chemo-mechanical processes that result in brain damage and ultimately loss of functionality is currently lacking. While modern mathematical models that focus on how to link brain mechanics to its biochemistry are essential in enhancing our understanding of brain science, the lack of experimental data required by these models as well as the complexity of the corresponding computations render these models hard to use in clinical applications. In this paper we propose a unified variational framework for the modeling of neuronal electromechanics. We introduce a constrained Lagrangian formulation that takes into account Newton's law of motion of a linear viscoelastic Kelvin–Voigt solid-state neuron as well as the classic Hodgkin–Huxley equations of the electronic neuron. The system of differential equations describing neuronal electromechanics is obtained by applying Hamilton's principle. Numerical simulations of possible damage dynamics in neurons will be presented. PMID:26236195
New facility in Hamilton to generate electricity from biosolids
Nolan, W. [Liberty Energy, Hamilton, ON (Canada); Thomson, M.; Ahluwalia, J. [Environ EC Canada, Mississauga, ON (Canada)
2009-07-15
Ontario's Green Energy Act was introduced in 2009 to facilitate progress toward greenhouse gas (GHG) reduction and to increase the amount of energy produced from renewable energy sources. This article described a technology that can be used to generate electricity from the biosolids that are generated at wastewater treatment plants and pulp and paper mills across Ontario. Liberty Energy Inc. is proposing to build a new renewable energy thermal electric power plant in Hamilton, Ontario. The facility will use waste biomass as fuel consisting of biosolids, or sewage sludge. These materials have traditionally been managed through land filling, land application, or incineration. The use of waste biomass for power generation will provide a long term, sustainable and environmentally friendly method to manage these waste materials. This article reviewed some of the thermal treatment technologies, including fixed hearth, multiple hearth, rotary kilns and fluidized bed reactors. The odour management plan for the facility includes sealed storage of biosolids and indoor receiving of both biosolids and biomass, with all venting to either the gasifier or a biofilter. The exhaust from the gasifier will be treated by selective catalytic and non-catalytic reduction technology, lime slurry wet scrubbers, fabric filters and powdered activated carbon scrubbers. 2 figs.
Value Functions for Certain Class of Hamilton Jacobi Equations
Anup Biswas; Rajib Dutta; Prosenjit Roy
2011-08-01
We consider a class of Hamilton Jacobi equations (in short, HJE) of type $$u_t+\\frac{1}{2}\\left(|u_{x_n}|^2+\\cdots+|u_{x_{n-1}}|^2\\right)+\\frac{e^u}{m}|u_{x_n}|^m=0,$$ in $\\mathbb{R}^n×\\mathbb{R}_+$ and >1, with bounded, Lipschitz continuous initial data. We give a Hopf-Lax type representation for the value function and also characterize the set of minimizing paths. It is shown that the minimizing paths in the representation of value function need not be straight lines. Then we consider HJE with Hamiltonian decreasing in of type $$u_t+H_1(u_{x_1},\\ldots,u_{x_i})+e^{-u}H_2(u_{x_{i+1}},\\ldots,u_{x_n})=0$$ where $H_1,H_2$ are convex, homogeneous of degree $n,m>1$ respectively and the initial data is bounded, Lipschitz continuous. We prove that there exists a unique viscosity solution for this HJE in Lipschitz continuous class. We also give a representation formula for the value function.
An electromechanical model of neuronal dynamics using Hamilton's principle.
Drapaca, Corina S
2015-01-01
Damage of the brain may be caused by mechanical loads such as penetration, blunt force, shock loading from blast, and by chemical imbalances due to neurological diseases and aging that trigger not only neuronal degeneration but also changes in the mechanical properties of brain tissue. An understanding of the interconnected nature of the electro-chemo-mechanical processes that result in brain damage and ultimately loss of functionality is currently lacking. While modern mathematical models that focus on how to link brain mechanics to its biochemistry are essential in enhancing our understanding of brain science, the lack of experimental data required by these models as well as the complexity of the corresponding computations render these models hard to use in clinical applications. In this paper we propose a unified variational framework for the modeling of neuronal electromechanics. We introduce a constrained Lagrangian formulation that takes into account Newton's law of motion of a linear viscoelastic Kelvin-Voigt solid-state neuron as well as the classic Hodgkin-Huxley equations of the electronic neuron. The system of differential equations describing neuronal electromechanics is obtained by applying Hamilton's principle. Numerical simulations of possible damage dynamics in neurons will be presented.
An Electromechanical Model of Neuronal Dynamics using Hamilton's Principle
Corina Stefania Drapaca
2015-07-01
Full Text Available Damage of the brain may be caused by mechanical loads such as penetration, blunt force, shock loading from blast, and by chemical imbalances due to neurological diseases and aging that trigger not only neuronal degeneration but also changes in the mechanical properties of brain tissue. An understanding of the interconnected nature of the electro-chemo-mechanical processes that result in brain damage and ultimately loss of functionality is currently lacking. While modern mathematical models that focus on how to link brain mechanics to its biochemistry are essential in enhancing our understanding of brain science, the lack of experimental data required by these models as well as the complexity of the corresponding computations render these models hard to use in clinical applications. In this paper we propose a unified variational framework for the modeling of neuronal electromechanics. We introduce a constrained Lagrangian formulation that takes into account Newton's law of motion of a linear viscoelastic Kelvin-Voigt solid-state neuron as well as the classic Hodgkin-Huxley equations of the electronic neuron. The system of differential equations describing neuronal electromechanics is obtained by applying Hamilton's principle. Numerical simulations of possible damage dynamics in neurons will be presented.
Mohammad Hamid
2010-01-01
Full Text Available Objective: To study the possible association between high levels of fetal haemoglobin(HbF in β-thalassemia intermedia patients and HS-111 and 3`HS1 sequence variations.Materials and Methods: In this study, the 3' HS-1 and HS-111 regions of 30 ß-thalassaemiaintermedia patients (ß°/ß° with high levels of HbF, 21 ß-thalassemia major patientsand 40 normal Iranian individuals were analyzed by single-strand conformation polymorphism(SSCP and polymerase chain reaction (PCR sequencing.Results: Two nucleotide variations in 3' HS111 (-21A>G and 3`HS1 (179C>T wereidentified. The most frequent sequence variation was 3' HS111 (-21A in the intermediapatients and 3`HS111 (-21G in the major thalassemia patients. In contrast to the 3`HS1marker, both 3'HS111 A and G variants showed a correlation with each studied group.Conclusion: The HS111 marker in conjunction with other parameters could be used asappropriate genetic markers to discriminate β-thalassemia intermedia patients (β°/β° withhigh levels of HbF from β-thalassemia major patients.
刘道军
2014-01-01
讨论带有Born-Infeld作用量的快子场所驱动的暴涨模型.首先给出了快子暴涨方程的Hamilton-Jacobi形式并且考虑如何去解Hamilton-Jacobi方程;然后讨论快子场的宇宙学扰动给出扰动场的模方程;最后,讨论了一个真实的由弦理论得来的滚动快子模型.
NUMERICAL METHOD BASED ON HAMILTON SYSTEM AND SYMPLECTIC ALGORITHM TO DIFFERENTIAL GAMES
无
2006-01-01
The resolution of differential games often concerns the difficult problem of two points border value (TPBV), then ascribe linear quadratic differential game to Hamilton system. To Hamilton system, the algorithm of symplectic geometry has the merits of being able to copy the dynamic structure of Hamilton system and keep the measure of phase plane. From the viewpoint of Hamilton system, the symplectic characters of linear quadratic differential game were probed; as a try, Symplectic-Runge-Kutta algorithm was presented for the resolution of infinite horizon linear quadratic differential game. An example of numerical calculation was given, and the result can illuminate the feasibility of this method. At the same time, it embodies the fine conservation characteristics of symplectic algorithm to system energy.
Hamilton-Jacobi method for classical mechanics in Grassmann algebra (in English)
Tabunshchyk, K. V.
We present the Hamilton--Jacobi method for the classical mechanics with the constrains in Grassmann algebra. Within the framework of this method the solution for the classical system characterized by the SUSY Lagrangian is obtained.
Hamilton-Jacobi theorems for regular reducible Hamiltonian systems on a cotangent bundle
Wang, Hong
2017-09-01
In this paper, some of formulations of Hamilton-Jacobi equations for Hamiltonian system and regular reduced Hamiltonian systems are given. At first, an important lemma is proved, and it is a modification for the corresponding result of Abraham and Marsden (1978), such that we can prove two types of geometric Hamilton-Jacobi theorem for a Hamiltonian system on the cotangent bundle of a configuration manifold, by using the symplectic form and dynamical vector field. Then these results are generalized to the regular reducible Hamiltonian system with symmetry and momentum map, by using the reduced symplectic form and the reduced dynamical vector field. The Hamilton-Jacobi theorems are proved and two types of Hamilton-Jacobi equations, for the regular point reduced Hamiltonian system and the regular orbit reduced Hamiltonian system, are obtained. As an application of the theoretical results, the regular point reducible Hamiltonian system on a Lie group is considered, and two types of Lie-Poisson Hamilton-Jacobi equation for the regular point reduced system are given. In particular, the Type I and Type II of Lie-Poisson Hamilton-Jacobi equations for the regular point reduced rigid body and heavy top systems are shown, respectively.
Thomas, Marion
2006-06-01
Robert Yerkes is a pivotal figure in American psychology and primatology in the first half of the twentieth century. As is well known, Yerkes first studied ape intelligence in 1915, on a visit to the private California laboratory of the psychiatrist Gilbert Hamilton, a former student. Less widely appreciated is how far the work done at the Hamilton lab, in its aims and ambitions as well as its techniques, served as a template for much of Yerkes's research thereafter. This paper uses the Hamilton-Yerkes relationship to re-examine Yerkes's career and, more generally, that of American psychology in the early twentieth century. Three points especially are emphasized: first, the role of Freudian psychoanalysis as a spur to Hamilton's experimental studies of ape intelligence; second, the importance of Hamilton's laboratory, with its semi-wild population of monkeys and ape, as a model for Yerkes's efforts to create a laboratory of his own; and third, the influence on Yerkes of Hamilton's optimism about experimental psychological studies of nonhuman primates as a source of lessons beneficial to a troubled human world.
Jónsson and HS Modules over Commutative Rings
Greg Oman
2014-01-01
Full Text Available Let R be a commutative ring with identity and let M be an infinite unitary R-module. (Unless indicated otherwise, all rings are commutative with identity 1≠0 and all modules are unitary. Then M is called a Jónsson module provided every proper submodule of M has smaller cardinality than M. Dually, M is said to be homomorphically smaller (HS for short if |M/N|<|M| for every nonzero submodule N of M. In this survey paper, we bring the reader up to speed on current research on these structures by presenting the principal results on Jónsson and HS modules. We conclude the paper with several open problems.
High-speed Neural Network HS-K-WTA-2%高速神经网络HS-K-WTA-2的研究
朱红; 陈清华; 刘国岁
2007-01-01
该文提出了一种新的K-Winners-Take-All神经网络:High-Speed-K-Winners-Take-All-2(HS-K-WTA-2).HS-K-WTA-2以竞争学习算法为基础.HS-K-WTA-2能够从任何一个数集中识别出K个较大的数,或K个较小的数.该文给出HS-K-WTA-2算法及算法复杂度的分析结果.用专门为研究K-WTA神经网络开发的仿真程序对HS-K-WTA-2、HS-K-WTA和Winstrons进行仿真研究.结果显示:当所取的数集N较大时,HS-K-WTA-2要比Winstrons和HS-K-WTA速度更快.HS-K-WTA-2的硬件实现比Winston的硬件实现要简单,比HS-K-WTA的硬件实现复杂.
High Speed Oblivious Random Access Memory (HS-ORAM)
2015-09-01
and Automated Teller Machines ( ATM ) security while generally impractical due to performance limitations and high acquisition costs. This idea has...HIGH SPEED OBLIVIOUS RANDOM ACCESS MEMORY (HS-ORAM) PRIVATE MACHINES , INC. SEPTEMBER 2015 FINAL TECHNICAL REPORT...UNIT NUMBER I1 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Private Machines Inc. 164 20th Street #3D Brooklyn, NY 11232 8. PERFORMING
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File list: NoD.Epd.20.AllAg.Hs_68 [Chip-atlas[Archive
Full Text Available NoD.Epd.20.AllAg.Hs_68 hg19 No description Epidermis Hs 68 SRX007036,SRX007038,SRX0...07037,SRX007035 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.Epd.20.AllAg.Hs_68.bed ...
Wei, Wei; Miller, Rebecca L; Leary, Julie A
2013-06-18
Heparan sulfate (HS) is one of the most complex and informative biopolymers found on the cell surface or in the extracellular matrix as either free HS fragments or constituents of HS proteoglycans (HSPGs). Analysis of free HS and HSPG sugar chains in human serum at the disaccharide level has great potential for early disease diagnosis and prognosis; however, the low concentration of HS in human serum, together with the complexity of the serum matrix, limits the information on HS. In this study, we present and validate the development of a new sensitive method for in-depth compositional analysis of free HS and HSPG sugar chains. This protocol involved several steps including weak anion exchange chromatography, ultrafiltration, and solid-phase extraction for enhanced detection prior to LC-MS/MS analysis. Using this protocol, a total of 51 serum samples from 26 premenopausal and 25 postmenopausal women were analyzed. Statistically significant differences in heparin/HS disaccharide profiles were observed. The proportion of N-acetylation and N-sulfation in both free HS and HSPG sugar chains were significantly different between pre- and postmenopausal women, indicating changes in N-deacetylase/N-sulfotransferases (NDSTs), the enzymes involved in the initial step of the biosynthetic pathway. Differences in the proportion of 6-O-sulfation suggest that 6-O-sulfotransferase and/or 6-O-sulfatase enzymes may also be implicated.
Ley, T J; Hug, B; Fiering, S; Epner, E; Bender, M A; Groudine, M
1998-06-30
To gain insights into the functions of individual DNA'se hypersensitive sites within the beta globin locus control region (LCR), we deleted the endogenous 5' HS-2 and HS-3 regions from the mouse germline using homologous recombination techniques. We demonstrated that the deletion of either murine 5' HS-2 or 5' HS-3 reduced the expression of the embryonic epsilon y and beta h1 globin genes minimally in yolk sac-derived erythrocytes, but that both knockouts reduced the output of the adult beta (beta-Major + beta-Minor) globin genes by approximately 30% in adult erythrocytes. When the selectable marker PGK-Neo cassette was retained within either the HS-2 or HS-3 region, a much more severe reduction in globin gene expression was observed at all developmental stages. PGK-Neo was shown to be expressed in an erythroid-specific fashion when it was retained in the HS-3 position. These results show that neither 5' HS-2 nor HS-3 is required for the activity of embryonic globin genes, nor are these sites required for correct developmental switching. However, each site is required for approximately 30% of the total LCR activity associated with adult beta-globin gene expression in adult red blood cells. Each site therefore contains some non-redundant information that contributes to adult globin gene function.
A quantitative test of Hamilton's rule for the evolution of altruism.
Markus Waibel
2011-05-01
Full Text Available The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb - c > 0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r is their genetic relatedness. While many studies have provided qualitative support for Hamilton's rule, quantitative tests have not yet been possible due to the difficulty of quantifying the costs and benefits of helping acts. Here we use a simulated system of foraging robots to experimentally manipulate the costs and benefits of helping and determine the conditions under which altruism evolves. By conducting experimental evolution over hundreds of generations of selection in populations with different c/b ratios, we show that Hamilton's rule always accurately predicts the minimum relatedness necessary for altruism to evolve. This high accuracy is remarkable given the presence of pleiotropic and epistatic effects as well as mutations with strong effects on behavior and fitness (effects not directly taken into account in Hamilton's original 1964 rule. In addition to providing the first quantitative test of Hamilton's rule in a system with a complex mapping between genotype and phenotype, these experiments demonstrate the wide applicability of kin selection theory.
Neural-Based Cuckoo Search of Employee Health and Safety (HS
Koffka Khan
2013-01-01
Full Text Available A study using the cuckoo search algorithm to evaluate the effects of using computer-aided workstations on employee health and safety (HS is conducted. We collected data for HS risk on employees at their workplaces, analyzed the data and proposed corrective measures applying our methodology. It includes a checklist with nine HS dimensions: work organization, displays, input devices, furniture, work space, environment, software, health hazards and satisfaction. By the checklist, data on HS risk factors are collected. For the calculation of an HS risk index a neural-swarm cuckoo search (NSCS algorithm has been employed. Based on the HS risk index, IHS four groups of HS risk severity are determined: low, moderate, high and extreme HS risk. By this index HS problems are allocated and corrective measures can be applied. This approach is illustrated and validated by a case study. An important advantage of the approach is its easy use and HS index methodology speedily pointing out individual employee specific HS risk.
李锐; 郝祥晖; 李登峰
2002-01-01
研究在窗函数的Fourier变换具有紧支集条件下,Sobolev空间Hs(Rd)上不存在Weyl-Heisenberg框架.这个结果表明:对Sobolev空间Hs(Rd)上的Weyl-Heisenberg框架的研究意义不大.
UNCONVENTIONAL HAMILTON-TYPE VARIATIONAL PRINCIPLES FOR DYNAMICS OF REISSNER SANDWICH PLATE
HUANG Wei-jiang; LUO En; SHE Hui
2006-01-01
According to the basic idea of classical yin-yang complementarity and modern dual-complementarity, in a simple and unified way proposed by Luo(1987), some unconventional Hamilton-type variational principles for dynamics of Reissner sandwich plate can be established systematically. The unconventional Hamilton-type variation principle can fully characterize the initial-boundary-value problem of this dynamics. In this paper, an important integral relation is given, which can be considered as the generalized principle of virtual work in mechanics. Based on this relation, it is possible not only to obtain the principle of virtual work in dynamics of Reissner sandwich plate, but also to derive systematically the complementary functionals for five-field, two-field and one-field unconventional Hamilton-type variational principles by the generalized Legender transformations. Furthermore, with this approach, the intrinsic relationship among the various principles can be explained clearly.
Computational method for the quantum Hamilton-Jacobi equation: one-dimensional scattering problems.
Chou, Chia-Chun; Wyatt, Robert E
2006-12-01
One-dimensional scattering problems are investigated in the framework of the quantum Hamilton-Jacobi formalism. First, the pole structure of the quantum momentum function for scattering wave functions is analyzed. The significant differences of the pole structure of this function between scattering wave functions and bound state wave functions are pointed out. An accurate computational method for the quantum Hamilton-Jacobi equation for general one-dimensional scattering problems is presented to obtain the scattering wave function and the reflection and transmission coefficients. The computational approach is demonstrated by analysis of scattering from a one-dimensional potential barrier. We not only present an alternative approach to the numerical solution of the wave function and the reflection and transmission coefficients but also provide a computational aspect within the quantum Hamilton-Jacobi formalism. The method proposed here should be useful for general one-dimensional scattering problems.
Hamilton and Hardy: Mentoring and Friendship in the Service of Occupational Health.
Sullivan, Marianne
This article explores the mentoring relationship between Alice Hamilton and Harriet Hardy, two female physician-researchers who had a tremendous impact on the development of the field of occupational health in the United States during the 20th century. The article relies on letters the women wrote to each other. Hamilton, the elder, supported and furthered Hardy's career by asking her to coauthor the second edition of a seminal occupational health text. After beginning this intellectual collaboration, Hamilton remained a mentor to Hardy, and a decades-long friendship ensued. The article explores their relationship within the historical, political, and social context in which the women worked and made remarkable contributions to public health.
On the Hamilton-Jacobi method in classical and quantum nonconservative systems
Dutra, A. de Souza; Correa, R. A. C.; Moraes, P. H. R. S.
2016-08-01
In this work we show how to complete some Hamilton-Jacobi solutions of linear, nonconservative classical oscillatory systems which appeared in the literature, and we extend these complete solutions to the quantum mechanical case. In addition, we obtain the solution of the quantum Hamilton-Jacobi equation for an electric charge in an oscillating pulsing magnetic field. We also argue that for the case where a charged particle is under the action of an oscillating magnetic field, one can apply nuclear magnetic resonance techniques in order to find experimental results regarding this problem. We obtain all results analytically, showing that the quantum Hamilton-Jacobi formalism is a powerful tool to describe quantum mechanics.
Glaucoma at the Hamilton Glaucoma Center and the University of California, San Diego
Robert N. Weinreb
2011-01-01
@@ Known for its unique cross-disciplinary investigative programs and clinical excellence, the scientists and clinicians at the Hamilton Glaucoma Center of the University of California, San Diego seek to enhance the discovery and translation of innovative research to clinical glaucoma care to prevent and cure glaucoma blindness.With state of the art laboratory and clinical facilities located on the La Jolla campus (Figure 1), the Center is a home for a worldrenowned team of scientists and staff.More than 100 post-doctoral fellows in Glaucoma, many of whom hold distinguished academic positions throughout the world, have been trained at the Hamilton Glaucoma Center and the University of California, San Diego.At the core of Hamilton Glaucoma Center activities are the outstanding faculty that are described below.
曹玉松
2013-01-01
从保险公司的角度出发,在投资基金价格服从带漂移的几何布朗运动的假定下,基于Hamilton-Jacobi-Bellman理论,给出了使得盈余终值的期望指数效用最大化的比例再保险函数的最优比例,及其各个风险市场的最优投资比例.%From the insurer's point of view,on the assumption that investment fund follows the Geometric Brownian motion,based on the theory of Hamilton-Jacobi-Bellman equation,the paper gives the optimal proportion of the proportional reinsurance and the capital amount of each risky investment markets,which can make the expected exponential utility of terminal wealth maximum.
Hawking radiation of Kerr-de Sitter black holes using Hamilton-Jacobi method
Ibungochouba Singh, T.; Ablu Meitei, I.; Yugindro Singh, K.
2013-05-01
Hawking radiation of Kerr-de Sitter black hole is investigated using Hamilton-Jacobi method. When the well-behaved Painleve coordinate system and Eddington coordinate are used, we get the correct result of Bekenstein-Hawking entropy before and after radiation but a direct computation will lead to a wrong result via Hamilton-Jacobi method. Our results show that the tunneling probability is related to the change of Bekenstein-Hawking entropy and the derived emission spectrum deviates from the pure thermal but it is consistent with underlying unitary theory.
Respiratory Medicine at McMaster University, Hamilton, Ontario: 1968 To 2013
Jones, Norman L.; Paul M O’Byrne
2014-01-01
The medical school at McMaster University (Hamilton, Ontario) was conceived in 1965 and admitted the first class in 1969. John Evans became the founding Dean and he invited Moran Campbell to be the first Chairman of the Department of Medicine. Moran Campbell, already a world figure in respiratory medicine and physiology, arrived at McMaster in September 1968, and he invited Norman Jones to be Coordinator of the Respiratory Programme.At that time, Hamilton had a population of 300,000, with two...
Obituary: George Hamilton Bowen Jr. (1925-2009)
Willson, Lee Anne; Struck, Curtis
2011-12-01
Our colleague and collaborator George Hamilton Bowen, Jr., passed away November 1, 2009 in Ames, Iowa. George was born June 20, 1925 in Tulsa, Oklahoma to George and Dorothy (Huntington) Bowen. He married Marjorie Brown June 19, 1948 in Redondo Beach, California; they had five children, with eight grandchildren and five great-grandchildren at the time of his death. George H. Bowen's third or perhaps his fourth career was in astronomy. He was drafted into the navy in 1944, at the end of his first year as a student at Caltech, and ended his war-time service as an electronic technician on the aircraft carrier Shangri-La. He later said "In just nine months, starting from scratch (Ohm's law!), we learned an amazing amount - not by memorization, of course, but by study and real understanding of the basic function of the most advanced AC circuits then being used for instrumentation, measurements, communications, control systems, and much more." He gained a confidence that he could quickly and accurately diagnose and solve technical problems that stood him well in future work. One accomplishment he took particular pride in was figuring out how the radar control used cams and gears to solve the trigonometry for accurate pointing. He also described how the captain was alarmed when weather conditions changed so that refraction no longer showed them distant, small boats around the curvature of Earth. After the war, George Bowen returned to undergraduate and eventually graduate study at Caltech, where he was recruited to the biophysics research group headed by future Nobel Laureate Max Delbrück. George often described his joy in working with these first-rate scientists and finding himself accepted as a part of the effort. He finished his BS with honors in 1949 and his PhD in 1953 with a thesis on "Kinetic Studies on the Mechanism of Photoreactivation of Bacteriophase T2 Inactivated by Ultraviolet Light" involving work with E Coli. This work was supported by grants from the U
符明昌; 周莲; 羊文芳; 苏显都
2016-01-01
目的：探讨血清脑钠肽前体(NT-proBNP)、高敏肌钙蛋白T (hs-TnT)、超敏C反应蛋白(hs-CRP)与急性心肌梗死(AMI)的相关性，并分析联合检测对AMI患者的诊断价值。方法选取2013年1月至2015年6月海南省第三人民医院112例AMI患者和80例体检者(对照组)，分别检测AMI患者3 h、12 h、1 d、3 d、7 d血清NT-proBNP、hs-TnT及hs-CRP水平，并与对照组进行比较。绘制受试工作特征曲线(ROC)评价NT-proBNP、hs-TnT及hs-CRP在AMI中的诊断价值，并应用Logistic回归模型分析AMI的独立危险因素。结果 AMI组血清NT-proBNP、hs-TnT及hs-CRP水平明显高于对照组，差异均有统计学意义(P<0.05)。血清NT-proBNP、Hs-TnT及Hs-CRP在AMI患者中出现峰值时间分别为1 d、12 h、3 d。应用Logistic回归模型对变量进行单因素及多因素分析，发现NT-proBNP、hs-TnT及hs-CRP是发生AMI的独立危险因素，其OR值及95%CI分别为1.012(0.874~1.136)、1.350(1.026~1.724)、1.168(1.014~1.337)。ROC曲线显示，NT-proBNP、hs-TnT、hs-CRP和三项联合检测的AUC及95%CI分别为：0.860(0.784~0.975)、0.834(0.762~0.905)、0.748(0.668~0.817)、0.885(0.794~0.971)。Spearman相关分析显示，NT-proBNP与hs-TnT呈明显正相关(r=0.679，P<0.05)，NT-proBNP与hs-CRP呈明显正相关(r=0.602，P<0.05)，hs-TnT与hs-CRP呈明显正相关(r=0.568，P<0.05)。结论 NT-proBNP、hs-TnT及hs-CRP是AMI发生的独立预测因子，联合检测可提高AMI诊断的准确性，有助于早期治疗并改善预后。%Objective To investigate the diagnostic value of serum N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT) and hypersensitive C-reactive protein (hs-CRP) in acute myocardial infarction (AMI), and to analyze their correlation. Methods A total of 112 patients of AMI (AMI group) and 80 sub-jects of physical examination (control group) in Third People's Hospital of Hainan Province were selected from January
Assessment of cytokine levels and hs-CRP in bipolar I disorder before and after treatment.
Uyanik, Vesile; Tuglu, Cengiz; Gorgulu, Yasemin; Kunduracilar, Hakan; Uyanik, Mehmet Sevki
2015-08-30
We aimed to assess the relationship between cytokine levels and the severity of the manic period in medication free patients. 30 Medication free patients and 28 healthy subjects (HS) were recruited. Plasma levels of pro-inflammatory, anti-inflammatory, inflammatory cytokines, and hs-CRP levels were investigated upon hospital admission, after six weeks follow up in bipolar disease manic episode and the results were compared to HS. The severity of the manic episodes was assessed according to the Young mania rating scale. TNF-α, INF-γ, IL-6 and hs-CRP levels were significantly higher in patients with manic episode of bipolar I disorder before treatment than HS. After treatment the levels of TNF-α, INF-γ, IL-6 and hs-CRP were observed to be significantly decreased. There was no difference between the levels of anti-inflammatory cytokines in patients before or after treatment of bipolar disorder and HS. hs-CRP was observed to be the only parameter correlated with clinical response. The most significant outcome of this study is the correlation between clinical outcome and hs-CRP levels in treatment naive manic episode bipolar type I patients. hs-CRP is the most consistent indicator according to pro-inflammatory, inflammatory and anti-inflammatory cytokines, in predicting treatment outcomes.
Hamilton Systems of the Compound KdV Equation%组合KdV方程的Hamilton系统
吕书强; 蔡春; 马青华
2014-01-01
In this article, according to Hamilton Systems of the KdV Equation, and proved Hamilton Systems of the Compound KdV Equation.%本文根据KdV方程的Hamilton系统，构造并证明了组合KdV方程的Hamilton系统。
Gharbi, A.; Touloum, S.; Bouda, A.
2015-04-01
We study the Klein-Gordon equation with noncentral and separable potential under the condition of equal scalar and vector potentials and we obtain the corresponding relativistic quantum Hamilton-Jacobi equation. The application of the quantum Hamilton-Jacobi formalism to the double ring-shaped Kratzer potential leads to its relativistic energy spectrum as well as the corresponding eigenfunctions.
Field, J. H.
2011-01-01
It is shown how the time-dependent Schrodinger equation may be simply derived from the dynamical postulate of Feynman's path integral formulation of quantum mechanics and the Hamilton-Jacobi equation of classical mechanics. Schrodinger's own published derivations of quantum wave equations, the first of which was also based on the Hamilton-Jacobi…
Field, J. H.
2011-01-01
It is shown how the time-dependent Schrodinger equation may be simply derived from the dynamical postulate of Feynman's path integral formulation of quantum mechanics and the Hamilton-Jacobi equation of classical mechanics. Schrodinger's own published derivations of quantum wave equations, the first of which was also based on the Hamilton-Jacobi…
N=2 gauge theories on the hemisphere $HS^4$
Gava, Edi; Muteeb, Nouman; Giraldo-Rivera, V I
2016-01-01
Using localization techniques, we compute the path integral of $N=2$ SUSY gauge theory coupled to matter on the hemisphere $HS^4$, with either Dirichlet or Neumann supersymmetric boundary conditions. The resulting quantities are wave-functions of the theory depending on the boundary data. The one-loop determinant are computed using $SO(4)$ harmonics basis. We solve kernel and co-kernel equations for the relevant differential operators arising from gauge and matter localizing actions. The second method utilizes full $SO(5)$ harmonics to reduce the computation to evaluating $Q_{SUSY}^2$ eigenvalues and its multiplicities. In the Dirichlet case, we show how to glue two wave-functions to get back the partition function of round $S^4$. We will also describe how to obtain the same results using $SO(5)$ harmonics basis.
3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.
Dam, G.B. ten; Kurup, S.; Westerlo, E.M. van de; Versteeg, E.M.M.; Lindahl, U.; Spillmann, D.; Kuppevelt, A.H.M.S.M. van
2006-01-01
Antibodies against heparan sulfate (HS) are useful tools to study the structural diversity of HS. They demonstrate the large sequential variation within HS and show the distribution of HS oligosaccharide sequences within their natural environment. We analyzed the distribution and the structural char
Hamilton decompositions of regular expanders: a proof of Kelly's conjecture for large tournaments
Kühn, Daniela
2012-01-01
A long-standing conjecture of Kelly states that every regular tournament on n vertices can be decomposed into (n-1)/2 edge-disjoint Hamilton cycles. We prove this conjecture for large n. In fact, we prove a far more general result, based on our recent concept of robust expansion and a new method for decomposing graphs. We show that every sufficiently large regular digraph G on n vertices whose degree is linear in n and which is a robust outexpander has a decomposition into edge-disjoint Hamilton cycles. This enables us to obtain numerous further results, e.g. as a special case we confirm a conjecture of Erdos on packing Hamilton cycles in random tournaments. As corollaries to the main result, we also obtain several results on packing Hamilton cycles in undirected graphs, giving e.g. the best known result on a conjecture of Nash-Williams. We also apply our result to solve a problem on the domination ratio of the Asymmetric Travelling Salesman problem, which was raised e.g. by Glover and Punnen as well as Alon,...
Mobile Air Monitoring: Measuring Change in Air Quality in the City of Hamilton, 2005-2010
Adams, Matthew D.; DeLuca, Patrick F.; Corr, Denis; Kanaroglou, Pavlos S.
2012-01-01
This paper examines the change in air pollutant concentrations between 2005 and 2010 occurring in the City of Hamilton, Ontario, Canada. After analysis of stationary air pollutant concentration data, we analyze mobile air pollutant concentration data. Air pollutants included in the analysis are CO, PM[subscript 2.5], SO[subscript 2], NO,…
An optimal L1-minimization algorithm for stationary Hamilton-Jacobi equations
Guermond, Jean-Luc
2009-01-01
We describe an algorithm for solving steady one-dimensional convex-like Hamilton-Jacobi equations using a L1-minimization technique on piecewise linear approximations. For a large class of convex Hamiltonians, the algorithm is proven to be convergent and of optimal complexity whenever the viscosity solution is q-semiconcave. Numerical results are presented to illustrate the performance of the method.
Air Quality in Hamilton: Who Is Concerned? Perceptions from Three Neighbourhoods
Simone, Dylan; Eyles, John; Newbold, K. Bruce; Kitchen, Peter; Williams, Allison
2012-01-01
This study investigates the factors influencing perceptions of air quality in the industrial city of Hamilton, Canada. The research employs data collected via a telephone survey of 1,002 adult residents in three neighbourhoods. Perceptions in the neighbourhoods were examined by individual socio-demographic factors (age, gender, marital and…
LI Wei-hua; LUO En; HUANG Wei-jiang
2007-01-01
According to the basic idea of classical yin-yang complementarity and modem dual-complementarity, in a simple and unified new way proposed by Luo, the unconventional Hamilton-type variational principles for geometrically nonlinear elastodynamics of orthogonal cable-net structures are established systematically, which can fully characterize the initial-boundary-value problem of this kind of dynamics. An important integral relation is made, which can be considered as the generalized principle of virtual work for geometrically nonlinear dynamics of orthogonal cable-net structures in mechanics. Based on such relationship, it is possible not only to obtain the principle of virtual work for geometrically nonlinear dynamics of orthogonal cable-net structures, but also to derive systematically the complementary functionals for five-field, four-field, three-field and two-field unconventional Hamilton-type variational principles, and the functional for the unconventional Hamilton-type variational principle in phase space and the potential energy functional for one-field unconventional Hamilton-type variational principle for geometrically nonlinear elastodynamics of orthogonal cable-net structures by the generalized Legendre transformation given in this paper. Furthermore, the intrinsic relationship among various principles can be explained clearly with this approach.
Octavia Butler and Virginia Hamilton: Black Women Writers and Science Fiction.
Hampton, Gregory Jerome; Brooks, Wanda M.
2003-01-01
Notes that African American literature has always had science fiction elements in its focus on narratives of the alienated and marginalized "other." Contends that Octavia Butler and Virginia Hamilton are two African American writers of science fiction who examine the connections between the stories of a culture and the genre of science…
Excellent reliability of the Hamilton Depression Rating Scale (HDRS-21) in Indonesia after training
Istriana, E.; Kurnia, A.; Weijers, A.; Hidayat, T.; Pinxten, W.J.L.; Jong, C.A.J. de; Schellekens, A.F.A.
2013-01-01
Introduction: The Hamilton Depression Rating Scale (HDRS) is the most widely used depression rating scale worldwide. Reliability of HDRS has been reported mainly from Western countries. The current study tested the reliability of HDRS ratings among psychiatric residents in Indonesia, before and afte
Hamilton-Jacobi equation and the breaking of the WKB approximation
Canfora, F. [Istituto Nazionale di Fisica Nucleare, GC di Salerno (Italy) and Dipartimento di Fisica E.R. Caianiello, Universita di Salerno, Via S. Allende, 84081 Baronissi (Salerno) (Italy)]. E-mail: canfora@sa.infn.it
2005-03-17
A simple method to deal with four-dimensional Hamilton-Jacobi equation for null hypersurfaces is introduced. This method allows to find simple geometrical conditions which give rise to the failure of the WKB approximation on curved spacetimes. The relation between such failure, extreme blackholes and the Cosmic Censor hypothesis is briefly discussed.
And Others; Gilmartin, Harvey
1979-01-01
Presented is a form of Hamilton's principle for classical mechanics appropriate to the study of arbitrary self-sustained vibrations in one dimension. It is applied as an approximate computational tool to the study of several examples of anharmonic oscillation. (Author/GA)
Helping in cooperatively breeding long-tailed tits: a test of Hamilton's rule.
Hatchwell, Ben J; Gullett, Philippa R; Adams, Mark J
2014-05-19
Inclusive fitness theory provides the conceptual framework for our current understanding of social evolution, and empirical studies suggest that kin selection is a critical process in the evolution of animal sociality. A key prediction of inclusive fitness theory is that altruistic behaviour evolves when the costs incurred by an altruist (c) are outweighed by the benefit to the recipient (b), weighted by the relatedness of altruist to recipient (r), i.e. Hamilton's rule rb > c. Despite its central importance in social evolution theory, there have been relatively few empirical tests of Hamilton's rule, and hardly any among cooperatively breeding vertebrates, leading some authors to question its utility. Here, we use data from a long-term study of cooperatively breeding long-tailed tits Aegithalos caudatus to examine whether helping behaviour satisfies Hamilton's condition for the evolution of altruism. We show that helpers are altruistic because they incur survival costs through the provision of alloparental care for offspring. However, they also accrue substantial benefits through increased survival of related breeders and offspring, and despite the low average relatedness of helpers to recipients, these benefits of helping outweigh the costs incurred. We conclude that Hamilton's rule for the evolution of altruistic helping behaviour is satisfied in this species.
Light Rail Transit in Hamilton: Health, Environmental and Economic Impact Analysis
Topalovic, P.; Carter, J.; Topalovic, M.; Krantzberg, G.
2012-01-01
Hamilton's historical roots as an electric, industrial and transportation-oriented city provide it with a high potential for rapid transit, especially when combined with its growing population, developing economy, redeveloping downtown core and its plans for sustainable growth. This paper explores the health, environmental, social and economic…
Two-item discrimination and Hamilton search learning in infant pigtailed macaque monkeys
Ha, J.C.; Mandell, D.J.; Gray, J.
2011-01-01
This study investigated how infant pigtailed macaque monkeys performed on two separate learning assessments, two-object discrimination/reversal and Hamilton search learning. Although the learning tasks have been tested on several species, including non-human primates, there have been no normative
Perceptions of Quality Life in Hamilton's Neighbourhood Hubs: A Qualitative Analysis
Eby, Jeanette; Kitchen, Peter; Williams, Allison
2012-01-01
This paper examines perceptions of quality of life in Hamilton, Ontario, Canada from the perspective of residents and key community stakeholders. A series of eight focus groups were conducted. Six sessions were held with residents of neighbourhood "hubs", areas characterized by high levels of poverty. The following themes were highlighted as…
Perceptions of Quality Life in Hamilton's Neighbourhood Hubs: A Qualitative Analysis
Eby, Jeanette; Kitchen, Peter; Williams, Allison
2012-01-01
This paper examines perceptions of quality of life in Hamilton, Ontario, Canada from the perspective of residents and key community stakeholders. A series of eight focus groups were conducted. Six sessions were held with residents of neighbourhood "hubs", areas characterized by high levels of poverty. The following themes were…
Deformed Hamilton-Jacobi Method in Covariant Quantum Gravity Effective Models
Benrong, Mu; Yang, Haitang
2014-01-01
We first briefly revisit the original Hamilton-Jacobi method and show that the Hamilton-Jacobi equation for the action $I$ of tunnelings of a fermionic particle from a charged black hole can be written in the same form as that of a scalar particle. For the low energy quantum gravity effective models which respect covariance of the curved spacetime, we derive the deformed model-independent KG/Dirac and Hamilton-Jacobi equations using the methods of effective field theory. We then find that, to all orders of the effective theories, the deformed Hamilton-Jacobi equations can be obtained from the original ones by simply replacing the mass of emitted particles $m$ with a parameter $m_{eff}$ that includes all the quantum gravity corrections. Therefore, in this scenario, there will be no corrections to the Hawking temperature of a black hole from the quantum gravity effects if its original Hawking temperature is independent of the mass of emitted particles. As a consequence, our results show that breaking covariance...
Angel, V.; Garvey, A.; Sydor, M.
2017-08-01
In the face of changing economies and patterns of development, the definition of heritage is diversifying, and the role of inventories in local heritage planning is coming to the fore. The Durand neighbourhood is a layered and complex area located in inner-city Hamilton, Ontario, Canada, and the second subject area in a set of pilot inventory studies to develop a new city-wide inventory strategy for the City of Hamilton,. This paper presents an innovative digital workflow developed to undertake the Durand Built Heritage Inventory project. An online database was developed to be at the centre of all processes, including digital documentation, record management, analysis and variable outputs. Digital tools were employed for survey work in the field and analytical work in the office, resulting in a GIS-based dataset that can be integrated into Hamilton's larger municipal planning system. Together with digital mapping and digitized historical resources, the Durand database has been leveraged to produce both digital and static outputs to shape recommendations for the protection of Hamilton's heritage resources.
Octavia Butler and Virginia Hamilton: Black Women Writers and Science Fiction.
Hampton, Gregory Jerome; Brooks, Wanda M.
2003-01-01
Notes that African American literature has always had science fiction elements in its focus on narratives of the alienated and marginalized "other." Contends that Octavia Butler and Virginia Hamilton are two African American writers of science fiction who examine the connections between the stories of a culture and the genre of science fiction.…
On the convergence rate of operator splitting for Hamilton-Jacobi equations with source terms
Jakobsen, Espen R.; Karlsen, Kenneth H.; Risebro, Nils Henrik
2000-02-01
We establish a rate of convergence for a semi-discrete operator splitting method applied to Hamilton-Jacobi equations with source terms. The method is based on sequentially solving a Hamilton-Jacobi equation and an ordinary differential equation. The Hamilton-Jacobi equation is solved exactly while the ordinary differential equation is solved exactly or by an explicit Euler method. We prove that the L{sup {infinity}} error associated with the operator splitting method is bounded by O({delta}t), where {delta}t is the splitting (or time) step. This error bound is an improvement over the existing O((sqroot)({delta}t)) bound due to Souganidis [40]. In the one dimensional case, we present a fully discrete splitting method based on an unconditionally stable front tracking method for homogenuous Hamilton-Jacobi equations. It is proved that this fully discrete splitting method possesses a linear convergence rate. Moreover, numerical results are presented to illustrate the theoreticle convergence results. (author)
Air Quality in Hamilton: Who Is Concerned? Perceptions from Three Neighbourhoods
Simone, Dylan; Eyles, John; Newbold, K. Bruce; Kitchen, Peter; Williams, Allison
2012-01-01
This study investigates the factors influencing perceptions of air quality in the industrial city of Hamilton, Canada. The research employs data collected via a telephone survey of 1,002 adult residents in three neighbourhoods. Perceptions in the neighbourhoods were examined by individual socio-demographic factors (age, gender, marital and…
Two-item discrimination and Hamilton search learning in infant pigtailed macaque monkeys
Ha, J.C.; Mandell, D.J.; Gray, J.
2011-01-01
This study investigated how infant pigtailed macaque monkeys performed on two separate learning assessments, two-object discrimination/reversal and Hamilton search learning. Although the learning tasks have been tested on several species, including non-human primates, there have been no normative re
Enhanced Preliminary Assessment. Task Order 2. Hamilton Army Airfield, Novato, California
1990-01-01
that Novato and San Rafael will likely continue to be the population centers of the county. 2.4.2 CIUMATE Hamilton Army Airfield is located...Sacramento Reserve Center (2) Modesto Reserve Center (1) San Pablo Reserve Center (2) Concord Reserve Center (4) Santa Rosa Reserve Center (4) A-7 -4 - IEI
Increased Hs-CRP/adiponectin ratio is associated with increase carotid intima-media thickness
Liao, Huocheng; Li, Zhiming; Zheng, Dongdan; Liu, Jianping; Liu, Yan; Xiao, Chun; Wang, Hongguang
2014-01-01
Background High sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression. The purpose of our study was to investigate the value of Hs-CRP and ANP ratio (Hs-CRP/APN ratio) on evaluating atherosclerosis progression. Method One hundred sixty consecutive participants underwent carotid intima-media thickness (CIMT) measured by ultrasound were enrolled and drawn fasting blood samples for plasma l...
Kadar hs-CRP pada pasien DM tipe 2 Dengan dan Tanpa Hipertensi
Ramadhani, Efi
2016-01-01
Introduction: More than 50% of patients with type-2 diabetes have hypertension. Hypertension contributes the development of cardiovascular disease. hs-CRP is an inflammation marker which is associated with cardiovascular risk. The aim of this study is to measure hs-CRP in type-2 diabetes with and without hypertension and to assess hs-CRP levels based on cardiovascular risk group. Methods: This study is an analytical observational cross-sectional study. Performed at the Department of Clini...
The possible existence of Hs in nature from a geochemical point of view
Ivanov, A V
2006-01-01
A hypothesis of the existence of a long-lived isotope 271Hs in natural molybdenites and osmirides is considered from a geochemical point of view. It is shown that the presence of Hs in these minerals can be explained only by making an additional ad hoc assumption on the existence of an isobaric pair of 271Bh-271Hs. This assumption could be tested by mass-spectrometric measurements of U, Pb, Kr, Xe, and Zr isotopic shifts.
李林
2009-01-01
@@ 越来越多的研究表明,同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)是动脉粥样硬化独立的危险因素[1～2].本文通过检测冠心病(CHD)患者与对照组血中的Hcy、hs-CRP水平,探讨CHD的严重程度与Hcy、hs-CRP的相关性.
Noll, K M; Wolfe, R S
1986-09-30
The structure of component B of the methylcoenzyme M methylreductase system of Methanobacterium thermoautotrophicum was recently found to be 7-mercaptoheptanoylthreonine phosphate (HS-HTP). The work described here demonstrates that this compound is found in two forms: enzyme-free and enzyme-bound. HS-HTP was found to be bound to component C of the methylcoenzyme M methylreductase system. The cofactor extracted from the protein by heat denaturation was found to comigrate with the mixed disulfide of HS-HTP and 2-mercaptoethanol by high-performance liquid chromatography, suggesting HS-HTP is not modified in the bound state.
In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse.
Bébin, Anne-Gaëlle; Carrion, Claire; Marquet, Marie; Cogné, Nadine; Lecardeur, Sandrine; Cogné, Michel; Pinaud, Eric
2010-04-01
In the mouse, the regulatory region located at the 3' end of the IgH locus includes four transcriptional enhancers: HS3a, HS1-2, HS3b, and HS4; the first three lie in a quasi-palindromic structure. Although the upstream elements HS3a and HS1-2 proved dispensable for Ig expression and class switch recombination (CSR), the joint deletion of HS3b and HS4 led to a consistent decrease in IgH expression in resting B cells and to a major CSR defect. Within this pair of distal enhancers, it was questionable whether HS3b and HS4 could be considered individually as elements critical for IgH expression and/or CSR. Studies in HS4-deficient mice recently revealed the role of HS4 as restricted to Igmicro-chain expression from the pre-B to the mature B cell stage and left HS3b as the last candidate for CSR regulation. Our present study finally invalidates the hypothesis that CSR could mostly rely on HS3b itself. B cells from HS3b-deficient animals undergo normal proliferation, germline transcription, and CSR upon in vitro stimulation with LPS; in vivo Ag-specific responses are not affected. In conclusion, our study highlights a major effect of the global ambiance of the IgH locus; enhancers demonstrated as being strongly synergistic in transgenes turn out to be redundant in their endogenous context.
Swenson, Sarah A
2015-02-01
W.D. Hamilton's theory of inclusive fitness aimed to define the evolved limits of altruism with mathematical precision. Although it was meant to apply universally, it has been almost irretrievably entwined with the particular case of social insects that featured in his famous 1964 papers. The assumption that social insects were central to Hamilton's early work contradicts material in his rich personal archive. In fact, careful study of Hamilton's notes, letters, diaries, and early essays indicates the extent to which he had humans in mind when he decided altruism was a topic worthy of biological inquiry. For this reason, this article reconsiders the role of extra-scientific factors in Hamilton's early theorizing. In doing so, it offers an alternative perspective as to why Hamilton saw self-sacrifice to be an important subject. Although the traditional narrative prioritizes his distaste for benefit-of-the-species explanations as a motivating factor behind his foundational work, I argue that greater attention ought to be given to Hamilton's hope that science could be used to address social ills. By reconsidering the meaning Hamilton intended inclusive fitness to have, we see that while he was no political ideologue, the socio-political relevance of his theory was nevertheless integral to its development.
Sistem Informasi Penjualan Pemasangan Kacafilm “HS Auto Film"
Noer Tjahja Moekthi Pratjitana
2013-07-01
Full Text Available The growing market share in many business areas especially in service area is causing the use of conventional accounting system being ineffective. One of the companies which still using the conventional one is a window film set-up service company called HS Auto Film. The process of processing sales data is less accurate and slower in the contrary of the developing sales data. Computer-based window film set-up Sales Information System is built in order to make the processing data more accurate and faster. The information system is built using Visual Basic programming language along with .NET framework technology and SQL Server database that embedded in the application itself. The making and development process of the Sales Information System is using waterfall method. Waterfall method consists of user requirement, analysis, design, implementation, and testing. Entity Relationship Diagram, Data Flow Diagram and Flowchart are also used in the Information System design. The output of this application design is a desktop application that can help user to control the set-up of window film, manage payment bill, and manage document in accounting in faster and more accurate way. The information system can be developed later using web-based system so that the development and maintenance can be done easier.
Complete genomic sequence of campylobacter jejuni subsp. jejuni HS:19 penner reference strain
Campylobacter jejuni subsp. jejuni (Cjj) infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). Capsular type Penner HS:19 is among several capsule types shown to be markers for GBS. This study describes the genome of Cjj HS:19...
Genomic Sequence of Campylobacter jejuni subsp. jejuni HS:19 Penner Serotype Reference Strain RM3420
Huynh, Steven; Heikema, Astrid P.
2017-01-01
ABSTRACT Campylobacter jejuni subsp. jejuni infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). Penner serotype HS:19 is among several capsular types shown to be markers for GBS. This study describes the genome of C. jejuni subsp. jejuni HS:19 Penner reference strain RM3420. PMID:28232429
Vegetable and Fruit Intakes Are Associated with hs-CRP Levels in Pre-Pubertal Girls.
Navarro, Pilar; de Dios, Olaya; Jois, Asha; Gavela-Pérez, Teresa; Gorgojo, Lydia; Martín-Moreno, José M; Soriano-Guillen, Leandro; Garcés, Carmen
2017-03-02
The influence of diet on inflammation in children remains unclear. We aimed to analyze the influence of diet on high-sensitivity C-reactive protein (hs-CRP) levels in a pre-pubertal population free of other influences that may affect hs-CRP levels. We determined hs-CRP levels in 571 six- to eight-year-old children using an hs-CRP ELISA kit. Information on food and nutrient intake was obtained through a food-frequency questionnaire. Overall dietary quality was assessed using the Healthy Eating Index (HEI). We found that girls in the highest tertile of hs-CRP levels had a higher intake of saturated fatty acid, and lower intakes of fiber and vitamin E and a lower HEI score when compared to those in tertiles 1 and 2. We also observed a significant decrease in fruit and vegetable intakes by hs-CRP tertile. Factor analysis showed that a dietary pattern that was loaded most strongly with vegetable, fruit, fiber and vitamin A and E intakes correlated negatively (-0.132, p hs-CRP. No such association was found in boys. In conclusion, our data show that girls with a poorer quality diet show higher hs-CRP levels already at a pre-pubertal age.
HS-4, a highly potent inhibitor of cell proliferation of human cancer cell
Gui-Lan Xing; Shu-Hong Tian; Xue-Li Xie; Jian Fu
2015-01-01
Objective:To investigate the antitumor activity of the compound HS-4 and the action mechanism.Methods:MTT method was used to testin vitroantitumor activity of the compound HS-4. Orthotopic xenotransplantation tumor model of liver cancer was established in nude mice, and,in vivoantitumor activity of compound HS-4 was tested with a small animal in-vivo imaging system. Sequencing of small RNA library and RNA library was performed in HS-4 treated tumor cell group and control group to investigate the anti-cancer mechanism of HS-4 at level of functional genomics, using high-throughput sequencing technology. Results:HS-4 was found to have relatively highin-vitro antitumor activity against liver cancer cells, gastric cancer cells, renal cancer cells, lung cancer cells, breast cancer cells and colon cancer cells. The IC50 values against SMMC-7721 and Bel-7402 of liver cancer cells were 0.14 and 0.13 nmol/L respectively, while the IC50 values against MGC-803 and SGC-7901 of gastric cancer cells were 0.19 and 0.21 nmol/L, respectively. It was demonstrated that HS- 4 possessed a better therapeutic effect in liver cancer.Conclusions: A new reliable orthotopic xenotransplantation tumor model of liver cancer in nude mice is established. The new compounds HS-4 was found to possess relatively highin vivo andin vitroantitumor activity against liver cancer cells.
Yang, Shu-Zheng; Feng, Zhong-Wen; Li, Hui-Ling
2017-02-01
We derive the Hamilton-Jacobi equation from the Dirac equation, then, with the help of the Hamilton-Jacobi equation, the the tunneling radiation behavior of the non-stationary spherical symmetry de Sitter black hole is discussed, at last, we obtained the tunneling rate and Hawking temperature. Our results showed that the Hamilton-Jacobi equation is a fundamental dynamic equation, it can widely be derived from the dynamic equations which describe the particles with any spin. Therefore, people can easy calculate the tunneling behavior from the black holes.
无
2004-01-01
CP-HS900是原Hitachi经济型产品CP-HS800的升级机型，采用3片0．55英寸液晶板和160W UHB灯泡。CP-HS900除配有CP-HS800的所有接口外还设计了RS-232C控制接口和USB鼠标控制接口，机器重量3．0kg。CP-HS900具有28dB降噪模式，演示过程中，听众不受噪音打扰。另
A Practical Approach to the Hamilton-Jacobi Formulation of Holographic Renormalization
Elvang, Henriette
2016-01-01
We revisit the subject of holographic renormalization for asymptotically AdS spacetimes. For many applications of holography, one has to handle the divergences associated with the on-shell gravitational action. The brute force approach uses the Fefferman-Graham (FG) expansion near the AdS boundary to identify the divergences, but subsequent reversal of the expansion is needed to construct the infinite counterterms. While in principle straightforward, the method is cumbersome and application/reversal of FG is formally unsatisfactory. Various authors have proposed an alternative method based on the Hamilton-Jacobi equation. However, this approach may appear to be abstract, difficult to implement, and in some cases limited in applicability. In this paper, we clarify the Hamilton-Jacobi formulation of holographic renormalization and present a simple algorithm for its implementation to extract cleanly the infinite counterterms. While the derivation of the method relies on the Hamiltonian formulation of general rel...
Generalisations of Hamilton's Rule Applied to Non-Additive Public Goods Games with Random Group Size
James A R Marshall
2014-07-01
Full Text Available Inclusive fitness theory has been described as being limited to certain special cases of social evolution. In particular some authors argue that the theory can only be applied to social interactions having additive fitness effects, and involving only pairs of individuals. This article takes an elegant formulation of non-additive public goods games from the literature, and shows how the two main generalisations of Hamilton's rule can be applied to such games when group sizes are random. In doing so inclusive fitness theory is thus applied to a very general class of social dilemmas, thereby providing further evidence for its generality. Interestingly, one of the two predominant versions of Hamilton's rule is found to be mathematically easier to apply to the scenario considered, despite both necessarily giving equivalent predictions.
Fleck, Marcelo Pio de Almeida; Chaves, Márcia Lorena Fagundes; Poirier-Littré, Marie France; Bourdel, Marie Chantal; Loo, Henri; Guelfi, Julien Daniel
2004-02-01
Among various research strategies for depression, the cross-cultural approach is a useful tool to investigate depressive disorders. The Hamilton Rating Scale for Depression was applied to 130 depressed inpatients in France and Brazil. Items were factorized by principal component analysis with Varimax rotation using the Kaiser or simulation method for factor sorting. Three factors were obtained in France, and four in Brazil. The first factor includes the core symptoms of depression in both samples. Qualitative and quantitative differences appeared in the anxiety factor between Brazilian and French samples. Insomnia items appeared as another factor for both groups. A limitation of this study is that it was conducted with small inpatient samples. Principal component analysis of the Hamilton Rating Scale for Depression for depressive inpatients in these two countries showed a similar structure. Differences observed were in the way anxiety items were distributed.
图的谱半径和Hamilton性%Spectral radius and Hamiltonicity of a graph
朱五华
2011-01-01
从图G的闭包理论角度去研究图的Hamilton性。利用图的补图谱半径的界，讨论了Hamilton图存在的谱条件，证明了n阶图G，如果它的补图的谱半径小于或等于（n-3）的算术平方根，则G是Hamilton图。%The Hamihonicity is studied from the closure theory of a graph G. We discuss some spectral conditions for the existence of Hamilton graph by using bounds of spectral radius of the Complement of a graph, and show that if G is a graph of order n with spectral radius of its complement is less than or equal to the arithmetic square root of （ n - 3） , then G is a Hamilton graph.
The Wasserstein geometry of nonlinear σ models and the Hamilton-Perelman Ricci flow
Carfora, Mauro
Nonlinear sigma models are quantum field theories describing, in the large deviation sense, random fluctuations of harmonic maps between a Riemann surface and a Riemannian manifold. Via their formal renormalization group analysis, they provide a framework for possible generalizations of the Hamilton-Perelman Ricci flow. By exploiting the heat kernel embedding introduced by Gigli and Mantegazza, we show that the Wasserstein geometry of the space of probability measures over Riemannian metric measure spaces provides a natural setting for discussing the relation between nonlinear sigma models and Ricci flow theory. In particular, we analyze the embedding of Ricci flow into a heat kernel renormalization group flow for dilatonic nonlinear sigma models, and characterize a non-trivial generalization of the Hamilton-Perelman version of the Ricci flow. We discuss in detail the monotonicity and gradient flow properties of this extended flow.
Computational method for the quantum Hamilton-Jacobi equation: bound states in one dimension.
Chou, Chia-Chun; Wyatt, Robert E
2006-11-07
An accurate computational method for the one-dimensional quantum Hamilton-Jacobi equation is presented. The Mobius propagation scheme, which can accurately pass through singularities, is used to numerically integrate the quantum Hamilton-Jacobi equation for the quantum momentum function. Bound state wave functions are then synthesized from the phase integral using the antithetic cancellation technique. Through this procedure, not only the quantum momentum functions but also the wave functions are accurately obtained. This computational approach is demonstrated through two solvable examples: the harmonic oscillator and the Morse potential. The excellent agreement between the computational and the exact analytical results shows that the method proposed here may be useful for solving similar quantum mechanical problems.
Relations between low-lying quantum wave functions and solutions of the Hamilton-Jacobi equation
Friedberg, R; Zhao Wei Qin
1999-01-01
We discuss a new relation between the low lying Schroedinger wave function of a particle in a one-dimentional potential V and the solution of the corresponding Hamilton-Jacobi equation with -V as its potential. The function V is $\\geq 0$, and can have several minina (V=0). We assume the problem to be characterized by a small anhamornicity parameter $g^{-1}$ and a much smaller quantum tunneling parameter $\\epsilon$ between these different minima. Expanding either the wave function or its energy as a formal double power series in $g^{-1}$ and $\\epsilon$, we show how the coefficients of $g^{-m}\\epsilon^n$ in such an expansion can be expressed in terms of definite integrals, with leading order term determined by the classical solution of the Hamilton-Jacobi equation. A detailed analysis is given for the particular example of quartic potential $V={1/2}g^2(x^2-a^2)^2$.
Superluminal Neutrinos and a Curious Phenomenon in the Relativistic Quantum Hamilton-Jacobi Equation
Matone, Marco
2011-01-01
OPERA's results, if confirmed, pose the question of superluminal neutrinos. We investigate the kinematics defined by the quantum version of the relativistic Hamilton-Jacobi equation, i.e. E^2=p^2c^2+m^2c^4+2mQc^2, with Q the quantum potential of the free particle. The key point is that the quantum version of the Hamilton-Jacobi equation is a third-order differential equation, so that it has integration constants which are missing in the Schr\\"odinger and Klein-Gordon equations. In particular, a non-vanishing imaginary part of an integration constant leads to a quantum correction to the expression of the velocity which is curiously in agreement with OPERA's results.
Conformal invariance, Noether symmetry, Lie symmetry and conserved quantities of Hamilton systems
Chen Rong; Xu Xue-Jun
2012-01-01
In this paper,the relation of the conformal invariance,the Noether symmetry,and the Lie symmetry for the Hamilton system is discussed in detail. The definition of the conformal invariance for Hamilton systems is given.The relation between the conformal invariance and the Noether symmetry is discussed,the conformal factors of the determining expressions are found by using the Noether symmetry,and the Noether conserved quantity resulted from the conformal invariance is obtained.The relation between the conformal invariance and the Lie symmetry is discussed,the conformal factors are found by using the Lie symmetry,and the Hojman conserved quantity resulted from the conformal invariance of the system is obtained.Two examples are given to illustrate the application of the results.
Deriving the Hamilton equations of motion for a nonconservative system using a variational principle
Tveter, Frank Thomas
1998-03-01
The classical derivation of the canonical transformation theory [H. Goldstein, Classical Mechanics, 2nd ed. (Addison-Wesley, Reading, 1981)] is based on Hamilton's principle which is only valid for conservative systems. This paper avoids this principle by using an approach that is basically reversed compared to the classical derivation. The Lagrange equations of motion are formulated in the undefined and general variable set {Q,P}, and the general Hamilton equations of motion are derived from the Lagrange equations by using a variational principle. The undefined general variables {Q,P} are defined through a transformation to a special (defined) variable set {q,p}. The transformation equations connecting the two sets are derived by using the invariants property of the value of the Lagrangian. This approach results in a more general interpretation of the generator function.
Large time behavior of weakly coupled systems of first-order Hamilton-Jacobi equations
Camilli, Fabio; Loreti, Paola; Nguyen, Vinh Duc
2011-01-01
We show a large time behavior result for class of weakly coupled systems of first-order Hamilton-Jacobi equations in the periodic setting. We use a PDE approach to extend the convergence result proved by Namah and Roquejoffre (1999) in the scalar case. Our proof is based on new comparison, existence and regularity results for systems. An interpretation of the solution of the system in terms of an optimal control problem with switching is given.
Bound States and Band Structure - a Unified Treatment through the Quantum Hamilton - Jacobi Approach
Ranjani, S S; Panigrahi, P K
2005-01-01
We analyze the Scarf potential, which exhibits both discrete energy bound states and energy bands, through the quantum Hamilton-Jacobi approach. The singularity structure and the boundary conditions in the above approach, naturally isolate the bound and periodic states, once the problem is mapped to the zero energy sector of another quasi-exactly solvable quantum problem. The energy eigenvalues are obtained without having to solve for the corresponding eigenfunctions explicitly. We also demonstrate how to find the eigenfunctions through this method.
Perturbation to Unified Symmetry and Adiabatic Invariants for Relativistic Hamilton Systems
ZHANG Ming-Jiang; FANG Jian-Hui; LU Kai; PANG Ting; LIN Peng
2009-01-01
Based on the concept of adiabatic invariant, the perturbation to unified symmetry and adiabatic invariants for relativistic Hamilton systems are studied. The definition of the perturbation to unified symmetry for the system is presented, and the criterion of the perturbation to unified symmetry is given. Meanwhile, the Noether adiabatic invariants, the generalized Hojman adiabatic invariants, and the Mei adiabatic invariants for the perturbed system are obtained.
WANG Yu-Sheng; ZHANG Xiao-Ni; YUAN Bao-He; FANG Jian-Hui; YANG Guo-Hong; LIN Peng; PANG Ting
2008-01-01
Based on the concept of higher-order adiabatic invariants of mechanical system with action of a small perturbation, the perturbation to Lie symmetry and generalized Hojman adiabatic invariants for the relativistic Hamilton system are studied. Perturbation to Lie symmetry is discussed under general infinitesimal transformation of groups in which time is variable. The form and the criterion of generalized Hojman adiabatic invariants for this system are obtained. Finally, an example is given to illustrate the results.
A Discontinuous Galerkin Finite Element Method for Hamilton-Jacobi Equations
Hu, Changqing; Shu, Chi-Wang
1998-01-01
In this paper, we present a discontinuous Galerkin finite element method for solving the nonlinear Hamilton-Jacobi equations. This method is based on the Runge-Kutta discontinuous Galerkin finite element method for solving conservation laws. The method has the flexibility of treating complicated geometry by using arbitrary triangulation, can achieve high order accuracy with a local, compact stencil, and are suited for efficient parallel implementation. One and two dimensional numerical examples are given to illustrate the capability of the method.
A Large Deviation, Hamilton-Jacobi Equation Approach to a Statistical Theory for Turbulence
2012-09-03
and its associated compressible Euler equations, Comptes Rendus Mathematique , (09 2011): 973. doi: 10.1016/j.crma.2011.08.013 2012/09/03 14:17:15 6...Hamilton-Jacobi PDE is shown to be well-posed. (joint work with T Nguyen, Journal de Mathematique Pures et Appliquees). Future works focusing on large time behavior for such equations is currently under its way. Technology Transfer
Hamilton dynamics for the Lefschetz thimble integration akin to the complex Langevin method
Fukushima, Kenji
2015-01-01
The Lefschetz thimble method, i.e., the integration along the steepest descent cycles, is an idea to evade the sign problem by complexifying the theory. We discuss that such steepest descent cycles can be identified as ground-state wave-functions of a supersymmetric Hamilton dynamics, which is described with a framework akin to the complex Langevin method. We numerically construct the wave-functions on a grid using a toy model and confirm their well-localized behavior.
Grajevskaja, Viktorija
2017-01-01
Danio rerio (Hamilton, 1822) is a powerful vertebrate model system, which provides a unique combination of advantages that are important for an investigation of cardiovascular development and regeneration. However, conditional mutagenesis, which is essential for dissecting a role of developmental genes in regeneration, has not been demonstrated in the adult zebrafish. This remains a main disadvantage of D. rerio model system. The main aim of this research project was to use insertional ge...
On the Hamilton-Jacobi-Bellman Equation by the Homotopy Perturbation Method
Abdon Atangana
2014-01-01
Full Text Available Our concern in this paper is to use the homotopy decomposition method to solve the Hamilton-Jacobi-Bellman equation (HJB. The approach is obviously extremely well organized and is an influential procedure in obtaining the solutions of the equations. We portrayed particular compensations that this technique has over the prevailing approaches. We presented that the complexity of the homotopy decomposition method is of order O(n. Furthermore, three explanatory examples established good outcomes and comparisons with exact solution.
Fu Jing-Li; Chen Li-Qun; Chen Xian-Wei
2006-01-01
This paper investigates the momentum-dependent symmetries for nonholonomic nonconservative Hamilton canonical systems. The definition and determining equations of the momentum-dependent symmetries are presented, based on the invariance of differential equations under infinitesimal transformations with respect to the generalized coordinates and generalized momentums. The structure equation and the non-Noether conserved quantities of the systems are obtained. The inverse issues associated with the momentum-dependent symmetries are discussed. Finally, an example is discussed to further illustrate the applications.
Adaptive dynamics via Hamilton-Jacobi approach and entropy methods for a juvenile-adult model.
Carrillo, José Antonio; Cuadrado, Sílvia; Perthame, Benoît
2007-01-01
We consider a nonlinear system describing a juvenile-adult population undergoing small mutations. We analyze two aspects: from a mathematical point of view, we use an entropy method to prove that the population neither goes extinct nor blows-up; from an adaptive evolution point of view, we consider small mutations on a long time scale and study how a monomorphic or a dimorphic initial population evolves towards an Evolutionarily Stable State. Our method relies on an asymptotic analysis based on a constrained Hamilton-Jacobi equation. It allows to recover earlier predictions in Calsina and Cuadrado [A. Calsina, S. Cuadrado, Small mutation rate and evolutionarily stable strategies in infinite dimensional adaptive dynamics, J. Math. Biol. 48 (2004) 135; A. Calsina, S. Cuadrado, Stationary solutions of a selection mutation model: the pure mutation case, Math. Mod. Meth. Appl. Sci. 15(7) (2005) 1091.] that we also assert by direct numerical simulation. One of the interests here is to show that the Hamilton-Jacobi approach initiated in Diekmann et al. [O. Diekmann, P.-E. Jabin, S. Mischler, B. Perthame, The dynamics of adaptation: an illuminating example and a Hamilton-Jacobi approach, Theor. Popul. Biol. 67(4) (2005) 257.] extends to populations described by systems.
Chou, Chia-Chun
2014-03-14
The complex quantum Hamilton-Jacobi equation-Bohmian trajectories (CQHJE-BT) method is introduced as a synthetic trajectory method for integrating the complex quantum Hamilton-Jacobi equation for the complex action function by propagating an ensemble of real-valued correlated Bohmian trajectories. Substituting the wave function expressed in exponential form in terms of the complex action into the time-dependent Schrödinger equation yields the complex quantum Hamilton-Jacobi equation. We transform this equation into the arbitrary Lagrangian-Eulerian version with the grid velocity matching the flow velocity of the probability fluid. The resulting equation describing the rate of change in the complex action transported along Bohmian trajectories is simultaneously integrated with the guidance equation for Bohmian trajectories, and the time-dependent wave function is readily synthesized. The spatial derivatives of the complex action required for the integration scheme are obtained by solving one moving least squares matrix equation. In addition, the method is applied to the photodissociation of NOCl. The photodissociation dynamics of NOCl can be accurately described by propagating a small ensemble of trajectories. This study demonstrates that the CQHJE-BT method combines the considerable advantages of both the real and the complex quantum trajectory methods previously developed for wave packet dynamics.
Schmid, L. A.
1977-01-01
The first and second variations are calculated for the irreducible form of Hamilton's Principle that involves the minimum number of dependent variables necessary to describe the kinetmatics and thermodynamics of inviscid, compressible, baroclinic flow in a specified gravitational field. The form of the second variation shows that, in the neighborhood of a stationary point that corresponds to physically stable flow, the action integral is a complex saddle surface in parameter space. There exists a form of Hamilton's Principle for which a direct solution of a flow problem is possible. This second form is related to the first by a Friedrichs transformation of the thermodynamic variables. This introduces an extra dependent variable, but the first and second variations are shown to have direct physical significance, namely they are equal to the free energy of fluctuations about the equilibrium flow that satisfies the equations of motion. If this equilibrium flow is physically stable, and if a very weak second order integral constraint on the correlation between the fluctuations of otherwise independent variables is satisfied, then the second variation of the action integral for this free energy form of Hamilton's Principle is positive-definite, so the action integral is a minimum, and can serve as the basis for a direct trail and error solution. The second order integral constraint states that the unavailable energy must be maximum at equilibrium, i.e. the fluctuations must be so correlated as to produce a second order decrease in the total unavailable energy.
程晓良; 徐渊辑; 孟炳泉
2005-01-01
An algorithm for numerical solution of discrete Hamilton-Jacobi-Bellman equations is proposed.The method begins with a suitable initial guess value of the solution,then finds a suitable matrix to linearize the system and constructs an iteration algorithm to generate the monotone sequence.The convergence of the algorithm for nonlinear discrete Hamilton-Jacobi-Bellman equations is proved.Some numerical examples are presented to confirm the effciency of this algorithm.
Ghosh, Esha; Rangan, C Pandu
2011-01-01
Hamiltonicity is an important property in parallel and distributed computation. Existence of Hamiltonian cycle allows efficient emulation of distributed algorithms on a network wherever such algorithm exists for linear-array and ring, and can ensure deadlock freedom in some routing algorithms in hierarchical interconnection networks. Hamiltonicity can also be used for construction of independent spanning tree and leads to designing fault tolerant protocols. Optical Transpose Interconnection Systems or OTIS (also referred to as two-level swapped network) is a widely studied interconnection network topology which is popular due to high degree of scalability, regularity, modularity and package ability. Surprisingly, to our knowledge, only one strong result is known regarding Hamiltonicity of OTIS - showing that OTIS graph built of Hamiltonian base graphs are Hamiltonian. In this work we consider Hamiltonicity of OTIS networks, built on Non-Hamiltonian base and answer some important questions. First, we prove tha...
Retinol-binding protein-4 and hs-CRP levels in patients with migraine.
Tanik, Nermin; Celikbilek, Asuman; Metin, Aslı; Gocmen, Ayse Yesim; Inan, Levent Ertugrul
2015-10-01
Retinol-binding protein-4 (RBP4) and high-sensitivity C-reactive protein (hs-CRP) levels are associated with inflammation in patients with migraine. The release of proinflammatory cytokines during migraine results in recurrent sterile neurogenic inflammation. This study aimed to determine the correlation between RBP4 and hs-CRP levels, and migraine, which is considered an inflammatory disease. The study included 48 migraine patients and 40 age- and gender-matched controls. Migraine was diagnosed according to International Classification of Headache Disorders-II. The serum RBP4 level was measured using a commercial ELISA kit and hs-CRP was measured using an enzyme immunoassay test kit. The serum RBP4 level was significantly lower in the migraine patients than in the controls (P hs-CRP level was significantly higher in the migraine patients (P hs-CRP levels did not differ between the migraine patients with and without aura (P > 0.05). Migraine headache severity, frequency and duration were not correlated with serum RBP or hs-CRP levels (P > 0.05). The observed high hs-CRP level and low RBP4 level in migraine patients suggest that vitamin A might play a major role in the pathogenesis of migraine. It is known that inflammation is a key factor in many diseases. Additional research might result in a better understanding of the anti-inflammatory effects of vitamin A.
Heat Pipe Heat Exchangers with Double Isolation Layers for Prevention of Interpath Leakage Project
National Aeronautics and Space Administration — Advanced Cooling Technologies, Inc. (ACT), supported by Hamilton Sundstrand, proposes to develop a heat pipe heat exchanger that is low mass and provides two levels...
The ISS Water Processor Catalytic Reactor as a Post Processor for Advanced Water Reclamation Systems
Nalette, Tim; Snowdon, Doug; Pickering, Karen D.; Callahan, Michael
2007-01-01
Advanced water processors being developed for NASA s Exploration Initiative rely on phase change technologies and/or biological processes as the primary means of water reclamation. As a result of the phase change, volatile compounds will also be transported into the distillate product stream. The catalytic reactor assembly used in the International Space Station (ISS) water processor assembly, referred to as Volatile Removal Assembly (VRA), has demonstrated high efficiency oxidation of many of these volatile contaminants, such as low molecular weight alcohols and acetic acid, and is considered a viable post treatment system for all advanced water processors. To support this investigation, two ersatz solutions were defined to be used for further evaluation of the VRA. The first solution was developed as part of an internal research and development project at Hamilton Sundstrand (HS) and is based primarily on ISS experience related to the development of the VRA. The second ersatz solution was defined by NASA in support of a study contract to Hamilton Sundstrand to evaluate the VRA as a potential post processor for the Cascade Distillation system being developed by Honeywell. This second ersatz solution contains several low molecular weight alcohols, organic acids, and several inorganic species. A range of residence times, oxygen concentrations and operating temperatures have been studied with both ersatz solutions to provide addition performance capability of the VRA catalyst.
Changing the conversation--the occupational health nurse's role in integrated HS3.
Weiss, Marjorie D
2009-07-01
Occupational health nurses have the skills and knowledge to provide a holistic perspective in advancing their company's triple bottom line, healthy people, healthy planet, and healthy profits. The HS3 model provides a road map for integrating health, safety, sustainability, and stewardship, all of which directly impact every company's triple bottom line. Occupational health nurses can use the HS3 model to promote healthy lifestyles, reduce risk and injuries, protect the natural environment, and improve resource alignment. Occupational health nurses have a unique opportunity to demonstrate the value they bring to their employers using synergistic HS3 planning that cost-effectively links work injury management, health promotion, environmental protection, safety training and surveillance, and regulatory compliance. Implementing the HS3 model requires occupational health nurses to be innovators who can change the conversation.
Osteoprotegerin improves risk detection by traditional cardiovascular risk factors and hsCRP
Mogelvang, Rasmus; Haahr-Pedersen, Sune; Bjerre, Mette;
2013-01-01
To evaluate the association of plasma osteoprotegerin (OPG) to hospitalisation for ischaemic heart disease (IHD), ischaemic stroke and all-cause mortality, and the effect of combining plasma OPG and high-sensitivity C-reactive protein (hsCRP).......To evaluate the association of plasma osteoprotegerin (OPG) to hospitalisation for ischaemic heart disease (IHD), ischaemic stroke and all-cause mortality, and the effect of combining plasma OPG and high-sensitivity C-reactive protein (hsCRP)....
HS2ST MEDIATED KIDNEY MESENCHYME INDUCTION REGULATES EARLY URETERIC BUD BRANCHING
Mita M. Shah; Sakurai, Hiroyuki; Sweeney, Derina E.; Gallegos, Thomas F.; Bush, Kevin T.; Esko, Jeffrey D.; Nigam, Sanjay K
2010-01-01
Heparan sulfate proteoglycans (HSPGs) are central modulators of developmental processes likely through their interaction with growth factors, such as GDNF, members of the FGF and TGFβ superfamilies, EGF receptor ligands and HGF. Absence of the biosynthetic enzyme, heparan sulfate 2-O-sulfotransferase (Hs2st) leads to kidney agenesis. Using a novel combination of in vivo and in vitro approaches, we have reanalyzed the defect in morphogenesis of the Hs2st−/− kidney. We observed that, while the ...
Suttiprapa, Sutas; Rinaldi, Gabriel; Brindley, Paul J
2012-06-01
Vesicular stomatitis virus glycoprotein (VSVG) pseudotyped murine leukemia virus (MLV) virions can transduce schistosomes, leading to chromosomal integration of reporter transgenes. To develop VSVG-MLV for functional genomics in schistosomes, the influence of the chicken β-globin cHS4 element, a prototypic chromatin insulator, on transgene expression was examined. Plasmid pLNHX encoding the MLV 5'- and 3'-Long Terminal Repeats flanking the neomycin phosphotransferase gene (neo) was modified to include, within the U3 region of the 3'-LTR, active components of cHS4 insulator, the 250 bp core fused to the 400 bp 3'-region. Cultured larvae of Schistosoma mansoni were transduced with virions from producer cells transfected with control or cHS4-bearing plasmids. Schistosomules transduced with cHS4 virions expressed 2-20 times higher levels of neo than controls, while carrying comparable numbers of integrated proviral transgenes. The findings not only demonstrated that cHS4 was active in schistosomes but also they represent the first report of activity of cHS4 in any Lophotrochozoan species, which has significant implications for evolutionary conservation of heterochromatin regulation. The findings advance prospects for transgenesis in functional genomics of the schistosome genome to discover intervention targets because they provide the means to enhance and extend transgene activity including for vector based RNA interference.
Evaluation of Usefulness of hs-CRP and Ferritin Assays in Patients with Nasal Polyps
Robert Partyka
2014-01-01
Full Text Available Background. Chronic nature of the nasal polyps, tendency to recurrence, and lack of satisfying treatment need the diagnostic’s parameters which show early inflammatory state as ferritin and hs-CRP. The Aim of Study. Assessment of hs-CRP and ferritin blood levels in nasal polyps patients in evaluation of treatment efficacy. Methods. All 38 patients were divided into 2 groups. Group I included 19 patients with anti-inflammatory therapy 2 weeks after surgery. Group II included 19 patients without anti-inflammatory therapy 2 weeks after surgery. The levels of hs-CRP and ferritin have been assessed before and 2 and 6 weeks after surgical treatment. Results. Research showed statistically significant difference of ferritin’s concentration between examined groups 6 weeks after surgery (P<0.05 and statistically significant difference of hs-CRP concentration 2 and 6 weeks after surgery (P<0.05. Conclusion. (1 The analysis of serum ferritin and hs-CRP concentrations can be useful in early postoperative detection of inflammatory state in patients with nasal polyps and for the effectiveness of therapy. (2 Lack of correlation between mean ferritin and hs-CRP serum levels, at each diagnostic and monitoring stage, shows that they are independent and cannot be determined interchangeably.
Prevalence of Hidradenitis Suppurativa (HS): A Population-Based Study in Olmsted County, Minnesota
Shahi, Varun; Alikhan, Ali; Vazquez, Benjamin G.; Weaver, Amy L.; Davis, Mark D.
2014-01-01
BACKGROUND/AIMS Hidradenitis suppurativa (HS) is a follicular occlusion disorder occurring in apocrine-rich regions of the skin. Estimates of the prevalence of this disorder have not been population-based. We sought to provide population-based information on the prevalence of HS in Olmsted County, Minnesota as of 1/1/2009. METHODS Rochester Epidemiology Project, a unique infrastructure that combines and makes accessible all medical records in Olmsted County since the 1960s, was used to collect population-based data on the prevalence of HS. RESULTS We identified 178 confirmed cases of HS that included 135 females and 43 males, and estimated the total sex- and age-adjusted prevalence in Olmsted County to be 127.8 per 100,000 or 0.13%. The total prevalence was significantly higher among women than men. CONCLUSION This study represents the first population-based investigation on the prevalence of HS. In this population-based cohort, HS was less prevalent than previous reports have suggested. PMID:25228133
A CORRELATION STUDY BETWEEN CONVENTIONAL LIPID PARAMETERS AND HS - CRP IN CORONARY HEART DISEASE
Rangaswamy
2015-05-01
Full Text Available BACKGROUND: Coronary heart disease (CHD is the most common form of heart disease. Changes in lifestyle, decreased physical activity, dietary modifications etc., in indian population is considered to be the major risk factor. By 2020 it is estimated that it will be th e major cause of death in the world. High sensitivity CRP (hs - CRP test measures very small amounts of CRP in the blood and is helpful even in healthy individuals to assess their potential risk for heart ailments. The hs - CRP levels are directly proportiona l to extent source of CHD which indicates that the hs - CRP has positive correlation with the disease burden. Hence the present study was undertaken. MATERIAL AND METHODS: The study was done by taking two groups controls and cases between the ages 25 - 60 year s. Fasting blood samples were collected and analysed for estimation of triglycerides, cholesterol, LDL - cholesterol, HDL - cholesterol and hs - crp levels. RESULT: Serum levels of cholesterol, TG, LDL - C, and hs - CRP (p - value 0.0001 were significantly increased and HDL - C (p - value 0.0002 was significantly decreased in cases as compared to healthy controls. CONCLUSION: It is seen that hs - CRP level is significantly elevated in cases (MI patients than the normal controls. So the present study shows a significant a nd positive correlation with conventional lipid profile parameters.
Viscosity solutions of two classes of coupled Hamilton-Jacobi-Bellman equations
Başar Tamer
2001-01-01
Full Text Available This paper studies viscosity solutions of two sets of linearly coupled Hamilton-Jacobi-Bellman (HJB equations (one for finite horizon and the other one for infinite horizon which arise in the optimal control of nonlinear piecewise deterministic systems where the controls could be unbounded. The controls enter through the system dynamics as well as the transitions for the underlying Markov chain process, and are allowed to depend on both the continuous state and the current state of the Markov chain. The paper establishes the existence and uniqueness of viscosity solutions for these two sets of HJB equations, whose Hamiltonian structures are different from the standard ones.
Code Red: Explaining Average Age of Death in the City of Hamilton
Patrick F. DeLuca
2015-11-01
Full Text Available The aim of this study is to identify the underlying factors that explain the average age of death in the City of Hamilton, Ontario, Canada, as identified in the Code Red Series of articles that were published in the city's local newspaper in 2010. Using a combination of data from the Canadian Census, the Government of Ontario and the Canadian Institute for Health Information, factor analysis was performed yielding three factors relating to poverty, working class, and health and aging. In a regression analysis these factors account for 42% of the total variability in the average ages of death observed at the census tract level of geography within the city.
基于DNA计算的Hamilton图%Hamilton Graph Based on DNA Computing
张家秀
2004-01-01
DNA computing is a novel method for solving a class of intractable computational problem,in which the computing can grow exponentially with problem size.Up to now,many accomplishments have been achieved to improve its performance and increase its reliability.Hamilton Graph Problem has been solved by means of molecular biology techniques.A small graph was encoded in molecules of DNA,and the "operations" of the computation were performed with standard protocols and enzymes.This work represents further evidence for the ability of DNA computing to solve NP-complete search problems.
MODERNOS Y MILITANTES. California a través de Harwell Hamilton Harris y Gordon Drake
PARRA MARTINEZ, JOSE
2013-01-01
A través del establecimiento de una genealogía moderna que recorre tres generaciones de arquitectos californianos entre mediados de los años 20 y finales de los años 40, desde Richard Neutra a Gordon Drake pasando por Harwell Hamilton Harris, esta tesis aborda el modo en que estos autores entendieron y expresaron su particular vinculación con el medio físico y el paisaje creativo del Sur de California. El análisis de las obras donde estos arquitectos coincidieron en su condición de discípulos...
Hamilton formalism and Noether symmetry for mechanico-electrical systems with fractional derivatives
Zhang Shi-Hua; Chen Ben-Yong; Fu Jing-Li
2012-01-01
This paper presents extensions to the traditional calculus of variations for mechanico-electrical systems containing fractional derivatives.The Euler-Lagrange equations and the Hamilton formalism of the mechanico-electrical systems with fractional derivatives are established.The definition and the criteria for the fractional generalized Noether quasisymmetry are presented. Furthermore,the fractional Noether theorem and conseved quantities of the systems are obtained by virtue of the invariance of the Hamiltonian action under the infinitesimal transformations.An example is presented to illustrate the application of the results.
Scalar particles emission from black holes with topological defects using Hamilton-Jacobi method
Jusufi, Kimet
2015-01-01
We study quantum tunneling of charged and uncharged scalar particles from the event horizon of Schwarzschild-de Sitter and Reissner-Nordstr\\"{o}m-de Sitter black holes pierced by an infinitely long spinning cosmic string and a global monopole. In order to find the Hawking temperature and the tunneling probability we solve the Klein-Gordon equation by using the Hamilton-Jacobi method and WKB approximation. We show that Hawking temperature is independent of the presence of topological defects in both cases.
On the Connection between the Hamilton-Jacobi-Bellman and the Fokker-Planck Control Frameworks
Annunziato, Mario
2014-09-01
In the framework of stochastic processes, the connection between the dynamic programming scheme given by the Hamilton-Jacobi-Bellman equation and a recently proposed control approach based on the Fokker-Planck equation is discussed. Under appropriate assumptions it is shown that the two strategies are equivalent in the case of expected cost functionals, while the FokkerPlanck formalism allows considering a larger class of objectives. To illustrate the connection between the two control strategies, the cases of an Itō stochastic process and of a piecewise-deterministic process are considered.
MacDonald, B.L., E-mail: macdonbl@mcmaster.ca [McMaster Univ., Dept. of Medical Physics and Applied Radiation Sciences, Hamilton, Ontario (Canada); Vanderstelt, J., E-mail: joshv@nray.ca [Nray Services Inc., Dundas, Ontario (Canada)
2015-03-15
Non-destructive analytical techniques are becoming increasingly important for the study of objects of cultural heritage interest. We present a study that applied two techniques: x-ray fluorescence (XRF) and neutron radiography, for the investigation of a time capsule recovered from an urban construction site in Gore Park, Hamilton. XRF analysis revealed the composition of the artifact, while n-radiography showed that its contents remained intact after being interred for 91 years. Results of this study demonstrate the value of non-destructive techniques for the analysis and preservation of cultural heritage. (author)
Park, Chandeok
This dissertation presents a general methodology for solving the optimal feedback control problem in the context of Hamiltonian system theory. It is first formulated as a two point boundary value problem for a standard Hamiltonian system, and the associated phase flow is viewed as a canonical transformation. Then relying on the Hamilton-Jacobi theory, we employ generating functions to develop a unified methodology for solving a variety of optimal feedback control formulations with general types of boundary conditions. The major accomplishment is to establish a theoretical connection between the optimal cost function and a special kind of generating function. Guided by this recognition, we are ultimately led to a new flexible representation of the optimal feedback control law for a given system, which is adjustable to various types of boundary conditions by algebraic conversions and partial differentiations. This adaptive property provides a substantial advantage over the classical dynamic programming method in the sense that we do not need to solve the Hamilton-Jacobi-Bellman equation repetitively for varying types of boundary conditions. Furthermore for a special type of boundary condition, it also enables us to work around an inherent singularity of the Hamilton-Jacobi-Bellman equation by a special algebraic transformation. Taking full advantage of these theoretical insights, we develop a systematic algorithm for solving a class of optimal feedback control problems represented by smooth analytic Hamiltonians, and apply it to problems with different characteristics. Then, broadening the practical utility of generating functions for problems where the relevant Hamiltonian is non-smooth, we construct a pair of Cauchy problems from the associated Hamilton-Jacobi equations. This alternative formulation is justified by solving problems with control constraints which usually feature non-smoothness in the control logic. The main result of this research establishes that
On a Hamilton-Poisson Approach of the Maxwell-Bloch Equations with a Control
Lăzureanu, Cristian
2017-09-01
In this paper we consider the 3D real-valued Maxwell-Bloch equations with a parametric control given by \\dot {x}=y+az+byz,\\dot {y}=xz,\\dot {z}=-xy (a,b\\in \\mathbb {R}). We give two Lie-Poisson structures of this system that are related with well-known Lie algebras. Moreover, we construct infinitely many Hamilton-Poisson realizations of this system. We also analyze the stability of the equilibrium points, as well as the existence of periodic orbits. In addition, we emphasize some connections between the energy-Casimir mapping of the considered system and the above-mentioned dynamical elements.
Scalar particles emission from black holes with topological defects using Hamilton-Jacobi method
Jusufi, Kimet
2015-11-01
We study quantum tunneling of charged and uncharged scalar particles from the event horizon of Schwarzschild-de Sitter and Reissner-Nordström-de Sitter black holes pierced by an infinitely long spinning cosmic string and a global monopole. In order to find the Hawking temperature and the tunneling probability we solve the Klein-Gordon equation by using the Hamilton-Jacobi method and WKB approximation. We show that Hawking temperature is independent of the presence of topological defects in both cases.
Coordinates Used in Derivation of Hawking Radiation via Hamilton-Jacobi Method
Liu, Bo; He, Xiaokai; Liu, Wenbiao
2009-05-01
Coordinates used in derivation of Hawking radiation via Hamilton-Jacobi method are investigated more deeply. In the case of a 4-dimensional Schwarzschild black hole, a direct computation leads to a wrong result. In the meantime, making use of the isotropic coordinate or invariant radial distance, we can get the correct conclusion. More coordinates including Painleve and Eddington-Finkelstein are tried to calculate the semi-classical Hawking emission rate. The reason of the discrepancy between naive coordinate and well-behaved coordinates is also discussed.
Fast methods for the Eikonal and related Hamilton- Jacobi equations on unstructured meshes.
Sethian, J A; Vladimirsky, A
2000-05-23
The Fast Marching Method is a numerical algorithm for solving the Eikonal equation on a rectangular orthogonal mesh in O(M log M) steps, where M is the total number of grid points. The scheme relies on an upwind finite difference approximation to the gradient and a resulting causality relationship that lends itself to a Dijkstra-like programming approach. In this paper, we discuss several extensions to this technique, including higher order versions on unstructured meshes in Rn and on manifolds and connections to more general static Hamilton-Jacobi equations.
Algebra and Geometry of Hamilton's Quaternions: 'Well, Papa, Can You Multiply Triplets?'
2016-06-01
Inspired by the relation between the algebra ofcomplex numbers and plane geometry, WilliamRowan Hamilton sought an algebra of triples forapplication to three-dimensional geometry. Unableto multiply and divide triples, he inventeda non-commutative division algebra of quadruples,in what he considered his most significantwork, generalizing the real and complex numbersystems. We give a motivated introduction toquaternions and discuss how they are related toPauli matrices, rotations in three dimensions, thethree sphere, the group SU(2) and the celebratedHopf fibrations.
Hamilton-Jacobi equation, heteroclinic chains and Arnol'd diffusion in three time scales systems
Gallavotti, G; Mastropietro, V; Gallavotti, Giovanni; Gentile, Guido; Mastropietro, Vieri
1998-01-01
Interacting systems consisting of two rotators and a point mass near a hyperbolic fixed point are considered, in a case in which the uncoupled systems have three very different characteristic time scales. The abundance of quasi periodic motions in phase space is studied via the Hamilton-Jacobi equation. The main result, a high density theorem of invariant tori, is derived by the classical canonical transformation method extending previous results. As an application the existence of long heteroclinic chains (and of Arnol'd diffusion) is proved for systems interacting through a trigonometric polynomial in the angle variables.
Dey, Bijoy K; Janicki, Marek R; Ayers, Paul W
2004-10-08
Classical dynamics can be described with Newton's equation of motion or, totally equivalently, using the Hamilton-Jacobi equation. Here, the possibility of using the Hamilton-Jacobi equation to describe chemical reaction dynamics is explored. This requires an efficient computational approach for constructing the physically and chemically relevant solutions to the Hamilton-Jacobi equation; here we solve Hamilton-Jacobi equations on a Cartesian grid using Sethian's fast marching method. Using this method, we can--starting from an arbitrary initial conformation--find reaction paths that minimize the action or the time. The method is demonstrated by computing the mechanism for two different systems: a model system with four different stationary configurations and the H+H(2)-->H(2)+H reaction. Least-time paths (termed brachistochrones in classical mechanics) seem to be a suitable chioce for the reaction coordinate, allowing one to determine the key intermediates and final product of a chemical reaction. For conservative systems the Hamilton-Jacobi equation does not depend on the time, so this approach may be useful for simulating systems where important motions occur on a variety of different time scales.
Sense of Place and Health in Hamilton, Ontario: A Case Study.
Williams, Allison; Kitchen, Peter
2012-09-01
The concept of sense of place has received considerable attention by social scientists in recent years. Research has indicated that a person's sense of place is influenced by a number of factors including the built environment, socio-economic status (SES), well-being and health. Relatively few studies have examined sense of place at the neighbourhood level, particularly among communities exhibiting different levels of SES. This article investigates sense of place among three neighbourhood groups in Hamilton, Ontario representing areas of low, mixed and high SES. It analyses data from a 16-point sense of place scale derived from the Hamilton Household Quality of Life Survey carried out in 2010-2011 among 1,002 respondents. The paper found that sense of place was highest among residents of the high SES neighbourhood group as well as among home owners, people residing in single-detached homes, retired residents and those living in their neighbourhood for more than 10 years. From a health perspective, the paper found that a strong association existed between sense of place and self-perceived mental health across the three neighbourhood groups. Furthermore, by way of regression modeling, the paper examined the factors influencing health-related sense of place. Among the sample of respondents, a strong connection was found between housing, particularly home ownership, and high levels of health-related sense of place.
A practical approach to the Hamilton-Jacobi formulation of holographic renormalization
Elvang, Henriette; Hadjiantonis, Marios
2016-06-01
We revisit the subject of holographic renormalization for asymptotically AdS spacetimes. For many applications of holography, one has to handle the divergences associated with the on-shell gravitational action. The brute force approach uses the Fefferman- Graham (FG) expansion near the AdS boundary to identify the divergences, but subsequent reversal of the expansion is needed to construct the infinite counterterms. While in principle straightforward, the method is cumbersome and application/reversal of FG is formally unsatisfactory. Various authors have proposed an alternative method based on the Hamilton-Jacobi equation. However, this approach may appear to be abstract, difficult to implement, and in some cases limited in applicability. In this paper, we clarify the Hamilton-Jacobi formulation of holographic renormalization and present a simple algorithm for its implementation to extract cleanly the infinite counterterms. While the derivation of the method relies on the Hamiltonian formulation of general relativity, the actual application of our algorithm does not. The work applies to any D-dimensional holographic dual with asymptotic AdS boundary, Euclidean or Lorentzian, and arbitrary slicing. We illustrate the method in several examples, including the FGPW model, a holographic model of 3d ABJM theory, and cases with marginal scalars such as a dilaton-axion system.
V. Angel
2017-08-01
Full Text Available In the face of changing economies and patterns of development, the definition of heritage is diversifying, and the role of inventories in local heritage planning is coming to the fore. The Durand neighbourhood is a layered and complex area located in inner-city Hamilton, Ontario, Canada, and the second subject area in a set of pilot inventory studies to develop a new city-wide inventory strategy for the City of Hamilton,. This paper presents an innovative digital workflow developed to undertake the Durand Built Heritage Inventory project. An online database was developed to be at the centre of all processes, including digital documentation, record management, analysis and variable outputs. Digital tools were employed for survey work in the field and analytical work in the office, resulting in a GIS-based dataset that can be integrated into Hamilton’s larger municipal planning system. Together with digital mapping and digitized historical resources, the Durand database has been leveraged to produce both digital and static outputs to shape recommendations for the protection of Hamilton’s heritage resources.
From classical Lagrangians to Hamilton operators in the Standard-Model Extension
Schreck, Marco
2016-01-01
In this article we investigate whether a theory based on a classical Lagrangian for the minimal Standard-Model Extension (SME) can be quantized such that the result is equal to the corresponding low-energy Hamilton operator obtained from the field-theory description. This analysis is carried out for the whole collection of minimal Lagrangians found in the literature. The upshot is that first quantization can be performed consistently. The unexpected observation is made that at first order in Lorentz violation and at second order in the velocity the Lagrangians are related to the Hamilton functions by a simple transformation. Under mild assumptions, it is shown that this holds universally. This result is used successfully to obtain classical Lagrangians for two complicated sectors of the minimal SME that have not been considered in the literature so far. Therefore, it will not be an obstacle anymore to derive such Lagrangians even for involved sets of coefficients - at least to the level of approximation state...
HERMITE WENO SCHEMES WITH LAX-WENDROFF TYPE TIME DISCRETIZATIONS FOR HAMILTON-JACOBI EQUATIONS
Jianxian Qiu
2007-01-01
In this paper, we use Hermite weighted essentially non-oscillatory (HWENO) schemes with a Lax-Wendroff time discretization procedure, termed HWENO-LW schemes, to solve Hamilton-Jacobi equations. The idea of the reconstruction in the HWENO schemes comes from the original WENO schemes, however both the function and its first derivative values are evolved in time and are used in the reconstruction. One major advantage of HWENO schemes is its compactness in the reconstruction. We explore the possibility in avoiding the nonlinear weights for part of the procedure, hence reducing the cost but still maintaining non-oscillatory properties for problems with strong discontinuous derivative. As a result,comparing with HWENO with Runge-Kutta time discretizations schemes (HWENO-RK) of Qiu and Shu [19] for Hamilton-Jacobi equations, the major advantages of HWENO-LW schemes are their saving of computational cost and their compactness in the reconstruction.Extensive numerical experiments are performed to illustrate the capability of the method.
A practical approach to the Hamilton-Jacobi formulation of holographic renormalization
Elvang, Henriette; Hadjiantonis, Marios [Department of Physics and Michigan Center for Theoretical Physics, University of Michigan,450 Church Str., Ann Arbor MI 48109 (United States)
2016-06-08
We revisit the subject of holographic renormalization for asymptotically AdS spacetimes. For many applications of holography, one has to handle the divergences associated with the on-shell gravitational action. The brute force approach uses the Fefferman-Graham (FG) expansion near the AdS boundary to identify the divergences, but subsequent reversal of the expansion is needed to construct the infinite counterterms. While in principle straightforward, the method is cumbersome and application/reversal of FG is formally unsatisfactory. Various authors have proposed an alternative method based on the Hamilton-Jacobi equation. However, this approach may appear to be abstract, difficult to implement, and in some cases limited in applicability. In this paper, we clarify the Hamilton-Jacobi formulation of holographic renormalization and present a simple algorithm for its implementation to extract cleanly the infinite counterterms. While the derivation of the method relies on the Hamiltonian formulation of general relativity, the actual application of our algorithm does not. The work applies to any D-dimensional holographic dual with asymptotic AdS boundary, Euclidean or Lorentzian, and arbitrary slicing. We illustrate the method in several examples, including the FGPW model, a holographic model of 3d ABJM theory, and cases with marginal scalars such as a dilaton-axion system.
From classical Lagrangians to Hamilton operators in the standard model extension
Schreck, M.
2016-07-01
In this article we investigate whether a theory based on a classical Lagrangian for the minimal Standard Model Extension (SME) can be quantized such that the result is equal to the corresponding low-energy Hamilton operator obtained from the field-theory description. This analysis is carried out for the whole collection of minimal Lagrangians found in the literature. The upshot is that the first quantization can be performed consistently. The unexpected observation is made that at first order in Lorentz violation and at second order in the velocity, the Lagrangians are related to the Hamilton functions by a simple transformation. Under mild assumptions, it is shown that this holds universally. That result is used successfully to obtain classical Lagrangians for two complicated sectors of the minimal SME that have not been considered in the literature so far. Therefore, it will not be an obstacle anymore to derive such Lagrangians even for involved sets of coefficients—at least to the level of approximation stated above.
Lenters, M. [Roundabouts Canada, Whitby, ON (Canada)
2003-07-01
The capacity and safety advantages of roundabouts over traffic signals is being increasingly recognized to moderate high traffic flow. The feasibility of establishing a roundabout at the intersection of Wilson Street, Meadowbrook Drive, and Hamilton Drive in the Town of Ancaster, Ontario was studied. A preliminary analysis of the potential operational performance of a modern roundabout for this intersection was conducted by SRM Associates, also known as Roundabouts Canada. Traffic capacity performance between a roundabout and a traffic signal was compared, as well as a cost benefit comparison (including a life cycle cost analysis) of a signalised intersection versus a roundabout. A capacity and safety prediction model, RODEL, was used to develop preliminary geometric parameters and the safety performance prediction for a roundabout. The results indicated that the implementation of a roundabout at said intersection would be beneficial in terms of traffic capacity and operational performance. It is expected that traffic flow in the next 20 to 25 years will not generate excessive queuing or delay. Consultations with the public have shown that the roundabout was the preferred intersection control. A single lane roundabout with single lane entries and exits was recommended. 6 refs., 8 figs.
Okasha, S; Martens, J
2016-03-01
Hamilton's original work on inclusive fitness theory assumed additivity of costs and benefits. Recently, it has been argued that an exact version of Hamilton's rule for the spread of a pro-social allele (rb > c) holds under nonadditive pay-offs, so long as the cost and benefit terms are defined as partial regression coefficients rather than pay-off parameters. This article examines whether one of the key components of Hamilton's original theory can be preserved when the rule is generalized to the nonadditive case in this way, namely that evolved organisms will behave as if trying to maximize their inclusive fitness in social encounters. © 2015 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2015 European Society For Evolutionary Biology.
Retrovirus silencer blocking by the cHS4 insulator is CTCF independent
Yao, Shuyuan; Osborne, Cameron S.; Bharadwaj, Rikki R.; Pasceri, Peter; Sukonnik, Tanya; Pannell, Dylan; Recillas-Targa, Félix; West, Adam G.; Ellis, James
2003-01-01
Silencing of retrovirus vectors poses a significant obstacle to genetic manipulation of stem cells and their use in gene therapy. We describe a mammalian silencer blocking assay using insulator elements positioned between retrovirus silencer elements and an LCRβ-globin reporter transgene. In transgenic mice, we show that retrovirus silencers are blocked by the cHS4 insulator. Silencer blocking is independent of the CTCF binding site and is most effective when flanking the internal reporter transgene. These data distinguish silencer blocking activity by cHS4 from its enhancer blocking activity. Retrovirus vectors can be created at high titer with one but not two internal dimer cHS4 cores. cHS4 in the LTRs has no effect on expression in transduced F9 cells, suggesting that position effect blocking is not sufficient to escape silencing. The Drosophila insulators gypsy and Scs fail to block silencing in transgenic mice, but gypsy stimulates vector expression 2-fold when located in the LTRs of an infectious retrovirus. The silencer blocking assay complements existing insulator assays in mammalian cells, provides new insight into mechanisms of insulation and is a valuable tool to identify additional silencer blocking insulators that cooperate with cHS4 to improve stem cell retrovirus vector design. PMID:12954767
Changes of levels of hs-CRP, Hsp70, and MPO in patients with preeclampsia
Xia Liu
2016-01-01
Objective:To observe the changes of the levels of hs-CRP, Hsp70, and MPO in patients with preeclampsia (PE) and their clinical significance. Methods:A total of 60 pregnant women with mild and severe PE who were admitted in our hospital from January, 2013 to March, 2014 were included in the study and divided into the mild group and the severe group with 30 cases in each group. The levels of serum hs-CRP, Hsp70, and MPO were detected, and their relations with PE were analyzed. The lipid metabolism related indicators were meanwhile detected. A total of 30 healthy later pregnant women at the same stage were served as the control group for comparative analysis. Results:The levels of serum hs-CRP, Hsp70, and MPO in the mild and severe PE group were significantly higher than those in the control group (P0.05). Conclusions: The abnormal lipid metabolism in different degrees exists in the pregnant women with PE, and hs-CRP, Hsp70, and MPO are together involved in the pathogenesis of PE. Detection of the levels of hs-CRP, Hsp70, and MPO in the pregnant women with PE can accurately reflect the condition of PE.
Poly(lactic-co-glycolic) Acid/Solutol HS15-Based Nanoparticles for Docetaxel Delivery.
Cho, Hyun-Jong; Park, Ju-Hwan; Kim, Dae-Duk; Yoon, In-Soo
2016-02-01
Docetaxel (DCT) is one of anti-mitotic chemotherapeutic agents and has been used for the treatment of gastric cancer as well as head and neck cancer, breast cancer and prostate cancer. Poly(lactic- co-glycolic) acid (PLGA) is one of representative biocompatible and biodegradable polymers, and polyoxyl 15 hydroxystearate (Solutol HS15) is a nonionic solubilizer and emulsifying agent. In this investigation, PLGA/Solutol HS15-based nanoparticles (NPs) for DCT delivery were fabricated by a modified emulsification-solvent evaporation method. PLGA/Solutol HS15/DCT NPs with about 169 nm of mean diameter, narrow size distribution, negative zeta potential, and spherical morphology were prepared. The results of solid-state studies revealed the successful dispersion of DCT in PLGA matrix and its amorphization during the preparation process of NPs. According to the result of in vitro release test, emulsifying property of Solutol HS15 seemed to contribute to the enhanced drug release from NPs at physiological pH. All these findings imply that developed PLGA/Solutol HS15-based NP can be a promising local anticancer drug delivery system for cancer therapy.
Gabella, W.E.; Ruth, R.D.; Warnock, R.L.
1988-05-01
Periodic solutions of the Hamilton-Jacobi equation determine invariant tori in phase space. The Fourier spectrum of a torus with respect to angular coordinates gives useful information about nonlinear resonances and their potential for causing instabilities. We describe a method to solve the Hamilton-Jacobi equation for an arbitrary accelerator lattice. The method works with Fourier modes of the generating functions, and imposes periodicity in the machine azimuth by a shooting method. We give examples leading to three-dimensional plots in a surface of section. It is expected that the technique will be useful in lattice optimization. 14 refs., 6 figs., 1 tab.
Schindler, Lisa Verena; Becker, Anna; Wickleder, Mathias Siegfried
2016-12-05
The unique hydrogenium-bis-tetrasulfate anion [H(S4 O13 )2 ](3-) in the crystal structure of Li3 [H(S4 O13 )2 ] (monoclinic, P21 /n (No. 14), Z=2, a=552.46(4) pm, b=939.70(6) pm, c=1876.6(1) pm, β=97.492(3)°, V=965.9(1)⋅10(6) pm(3) ) is the longest protonated polysulfate chain ever observed. Very strong symmetrical hydrogen bonds are a bold feature of the crystal structure. The protonation of a very weak base such as [S4 O13 ](2-) and accordingly the stabilization of the first base of the superacid H2 S4 O13 is a significant success towards the still elusive polysulfuric acids.
DEVELOPMENT OF THE HS99 AIR TRANSPORT TYPE A FISSILE PACKAGE
Blanton, P.; Eberl, K.
2012-07-10
An air-transport Type A Fissile radioactive shipping package for the transport of special form uranium sources has been developed by the Savannah River National Laboratory (SRNL) for the Department of Homeland Security. The Package model number is HS99 for Homeland Security Model 99. This paper presents the major design features of the HS99 and highlights engineered materials necessary for meeting the design requirements for this light-weight Type AF packaging. A discussion is provided demonstrating how the HS99 complies with the regulatory safety requirements of the Nuclear Regulatory Commission. The paper summarizes the results of structural testing to specified in 10 CFR 71 for Normal Conditions of Transport and Hypothetical Accident Conditions events. Planned and proposed future missions for this packaging are also addressed.
ICARE-HS: atmospheric correction of airborne hyperspectral urban images using 3D information
Ceamanos, Xavier; Briottet, Xavier; Roussel, Guillaume; Gilardy, Hugo
2016-10-01
The algorithm ICARE-HS (Inversion Code for urban Areas Reflectance Extraction using HyperSpectral imagery) is presented in this paper. ICARE-HS processes airborne hyperspectral images for atmospheric compensation taking into account the strong relief of urban areas. A digital surface model is used to provide the 3D information, which is key to simulating relief-related effects such as shadow casting, multiple reflections between objects and variable illumination depending on local solid angle of view of the sky. Some of these effects are modeled using ray tracing techniques. ICARE-HS is applied to airborne hyperspectral data of the city center of Toulouse, which are also processed by a standard atmospheric correction method for comparison.
Vincent-Fabert, Christelle; Truffinet, Véronique; Fiancette, Remi; Cogné, Nadine; Cogné, Michel; Denizot, Yves
2009-06-01
Several studies have reported that regulatory elements located 3' of the IgH locus (namely hs3a, hs1,2, hs3b, and hs4) might play a role during class switch recombination (CSR) and Ig synthesis. While individual deletion of hs3a or hs1,2 had no effect, pairwise deletion of hs3b (an inverted copy of hs3a) and hs4 markedly affected CSR and Ig expression. Among these two elements, hs4 was tentatively presented with the master role due to its unique status within the 3' regulatory region: distal position outside repeated regions, early activation in pre-B cells, strong activity throughout B cell ontogeny. To clarify its role, we generated mice with a clean deletion of the hs4 after replacement with a floxed neo(R) cassette. Surprisingly, and as for previous deletion of hs3a or hs1,2, deletion of hs4 did not affect either in vivo CSR or the secretion level of any Ig isotype. In vitro CSR and Ig secretion in response to LPS and cytokines was not affected either. The only noticeable effects of the hs4 deletion were a decrease in the number of B splenocytes and a decreased membrane IgM expression. In conclusion, while dispensable for CSR and Ig transcription in plasma cells, hs4 mostly appears to contribute to Ig transcription in resting B lymphocytes.
Waist Circumference was Positively Correlated with Chemerin, Retinol-Binding Protein 4 and hsCRP
Lucia Herminawati
2012-04-01
Full Text Available BACKGROUND: Central obesity is associated with various chronic metabolic disorders characterized by abnormal cytokine production, increased acute phase reactants, and activation of inflammatory signaling pathways. This study was aimed to investigate the association of waist circumference, chemerin, and retinol binding protein (RBP-4 with inflammation in men with central obesity. METHODS: The research was conducted with a crosssectional design involving 68 centrally obese male subjects aged 30 to 60 years old, with waist circumference (WC >90 cm. All subjects fulfilled the inclusion and exclusion criteria. Anthropometric parameters, fasting glucose, creatinine, SGOT, SGPT, and hsCRP were measured. Serum concentrations of chemerin and RBP4 were measured by ELISA. RESULTS: The trend lines showed that chemerin, RBP4 and hsCRP increased with WC. Pearson correlation test showed a positively significant correlation between WC and hsCRP (r=0.242, p<0.05; and also between chemerin and hsCRP (r=0.244, p<0.05 and RBP4 (r=0.321, p<0.01. Subjects were stratified into four groups based on their chemerin and RBP4 levels (high chemerin/high RBP4, high chemerin/low RBP4, low chemerin/high RBP4, or low chemerin/low RBP4. Subjects who were in the high chemerin/low RBP4 group were more likely to have high level of inflammation (47.6%, but subjects with high chemerin/high RBP4 showed low level of inflammation (42.9% as compared with the other three groups. CONCLUSIONS: We concluded that increased WC was correlated with elevated levels of chemerin, RBP4 and hsCRP. High chemerin was correlated with increased level of RBP4 as well as with high level of inflammation. KEYWORDS: waist circumference, chemerin, RBP4, hsCRP, inflammation.
Yan, Yi; Pieretti, Joyce; Ju, Zhongliang; Wei, Shiniu; Christin, John R; Bah, Fatmata; Birshtein, Barbara K; Eckhardt, Laurel A
2011-08-01
Immunoglobulin heavy chain (IgH) genes are formed, tested, and modified to yield diverse, specific, and high affinity antibody responses to antigen. The processes involved must be regulated, however, to avoid unintended damage to chromosomes. The 3' regulatory region of the Igh locus plays a major role in regulating class-switch recombination (CSR), the process by which antibody effector functions are modified during an immune response. Loss of all known enhancer-like elements in this region dramatically impairs CSR, but individual element deletions have no effect on this process. In the present study, we explored the hypothesis that an underlying functional redundancy in the homologous elements hs3a and hs3b was masking the importance of either element to CSR. Several transgenic mouse lines were generated, each carrying a bacterial artificial chromosome transgene that mimicked Igh locus structure but in which hs3a was missing and hs3b was flanked by loxP sites. Matings to Cyclization Recombination Enzyme-expressing mice established "pairs" of lines that differed only in the presence or absence of hs3b. Remarkably, CSR remained robust in the absence of both hs3a and hs3b, suggesting that the remaining two elements of the 3' regulatory region, hs1.2 and hs4, although individually dispensable for CSR, are, together, sufficient to support CSR.
Hitzl, D. L.; Zele, F.
Recently, the application of Hamilton's law of varying action to initial value problems in dynamics has been generalized and simplified. Using the Hitzl et al. (1984) new integral variation method, approximate solutions can be constructed to arbitrary initial value problems involving systems of first-order ordinary differential equations. The new constructive technique is briefly described, and the method is illustrated with two example problems: (1) the damped oscillator (two linear differential equations), and (2) the Lagrange planetary equations with zonal harmonics and drag (a highly nonlinear system of six coupled first-order differential equations). Numerical results confirm that the integral variation method indeed provides accurate approximate analytical solutions over a specified finite time interval.
Hybrid massively parallel fast sweeping method for static Hamilton-Jacobi equations
Detrixhe, Miles; Gibou, Frédéric
2016-10-01
The fast sweeping method is a popular algorithm for solving a variety of static Hamilton-Jacobi equations. Fast sweeping algorithms for parallel computing have been developed, but are severely limited. In this work, we present a multilevel, hybrid parallel algorithm that combines the desirable traits of two distinct parallel methods. The fine and coarse grained components of the algorithm take advantage of heterogeneous computer architecture common in high performance computing facilities. We present the algorithm and demonstrate its effectiveness on a set of example problems including optimal control, dynamic games, and seismic wave propagation. We give results for convergence, parallel scaling, and show state-of-the-art speedup values for the fast sweeping method.
Leclerc, M
2012-01-01
We introduce a symmetric Poisson bracket that allows us to describe anticommuting fields on a classical level in the same way as commuting fields, without the use of Grassmann variables. By means of a simple example, we show how the Dirac bracket for the elimination of the second class constraints can be introduced, how the classical Hamiltonian equations can be derived and how quantization can be achieved through a direct correspondence principle. Finally, we show that the semiclassical limit of the corresponding Schroedinger equation leads back to the Hamilton-Jacobi equation of the classical theory. Summarizing, it is shown that the relations between classical and quantum theory are valid for fermionic fields in exactly the same way as in the bosonic case, and that there is no need to introduce anticommuting variables on a classical level.
Buenker, R J
2003-01-01
The erroneous prediction of the speed of light in dispersive media has been looked upon historically as unequivocal proof that Newton's corpuscular theory is incorrect. Examination of his arguments shows that they were only directly applicable to the momentum of photons, however, leaving open the possibility that the cause of his mistake was the unavailability of a suitable mechanical theory to enable a correct light speed prediction, rather than his use of a particle model. It is shown that Hamilton's canonical equations of motion remove Newton's error quantitatively, and also lead to the most basic formulas of quantum mechanics without reference to any of the pioneering experiments of the late nineteenth century. An alternative formulation of the wave-particle duality principle is then suggested which allows the phenomena of interference and diffraction to be understood in terms of statistical distributions of large populations of photons or other particles.
Hamilton-Jacobi method for molecular distribution function in a chemical oscillator.
Nakanishi, Hiizu; Sakaue, Takahiro; Wakou, Jun'ichi
2013-12-07
Using the Hamilton-Jacobi method, we solve chemical Fokker-Planck equations within the Gaussian approximation and obtain a simple and compact formula for a conditional probability distribution. The formula holds in general transient situations, and can be applied not only to a steady state but also to an oscillatory state. By analyzing the long time behavior of the solution in the oscillatory case, we obtain the phase diffusion constant along the periodic orbit and the steady distribution perpendicular to it. A simple method for numerical evaluation of these formulas are devised, and they are compared with Monte Carlo simulations in the case of Brusselator as an example. Some results are shown to be identical to previously obtained expressions.
A Hamilton-Jacobi-Bellman approach for termination of seizure-like bursting.
Wilson, Dan; Moehlis, Jeff
2014-10-01
We use Hamilton-Jacobi-Bellman methods to find minimum-time and energy-optimal control strategies to terminate seizure-like bursting behavior in a conductance-based neural model. Averaging is used to eliminate fast variables from the model, and a target set is defined through bifurcation analysis of the slow variables of the model. This method is illustrated for a single neuron model and for a network model to illustrate its efficacy in terminating bursting once it begins. This work represents a numerical proof-of-concept that a new class of control strategies can be employed to mitigate bursting, and could ultimately be adapted to treat medically intractible epilepsy in patient-specific models.
The Classical Limit of Minimal Length Uncertainty Relation:Revisit with the Hamilton-Jacobi Method
Guo, Xiaobo; Yang, Haitang
2015-01-01
The existence of a minimum measurable length could deform not only the standard quantum mechanics but also classical physics. The effects of the minimal length on classical orbits of particles in a gravitation field have been investigated before, using the deformed Poisson bracket or Schwarzschild metric. In this paper, we use the Hamilton-Jacobi method to study motions of particles in the context of deformed Newtonian mechanics and general relativity. Specifically, the precession of planetary orbits, deflection of light, and time delay in radar propagation are considered in this paper. We also set limits on the deformation parameter by comparing our results with the observational measurements. Finally, comparison with results from previous papers is given at the end of this paper.
Saroj Kumar Ghosh
2015-08-01
Full Text Available Organization of various cells lining the olfactory mucosa of Puntius ticto (Hamilton, 1822 were described by light as well as scanning electron microscopy. The paired olfactory chambers located antero-dorsal to the eyes and communicated outside through anterior and posterior nasal openings. The oval shaped olfactory rosette lied at the bottom of chamber and composed of 18-20 lamellae arranged on either side of median raphe. Sensory and non-sensory regions were distributed separately on each lamella. The sensory epithelium consisted mainly of two distinct morphological forms: ciliated and microvillous receptor cells. The non-sensory epithelium contained ciliated non-sensory cells, stratified epithelial cells with concentric microridges and mucous cells. Basal cells were situated at the deeper part of the epithelium, adjacent to the central core. The functional significance of cellular components of the olfactory epithelium was discussed with the habit and habitat of fish.
Binding of polycyclic aromatic hydrocarbons by size classes of particulate in Hamilton Harbor water
Leppard, G.G. [National Water Research Inst., Burlington, Ontario (Canada). Aquatic Ecosystem Protection Branch]|[McMaster Univ., Hamilton, Ontario (Canada). Dept. of Biology; Flannigan, D.T. [McMaster Univ., Hamilton, Ontario (Canada). Dept. of Biology; Mavrocordatos, D. [McMaster Univ., Hamilton, Ontario (Canada). Dept. of Biology]|[Univ. of Lausanne (Switzerland). Dept. of Chemistry; Marvin, C.H. [McMaster Univ., Hamilton, Ontario (Canada). Dept. of Chemistry]|[Agriculture and Agri-Food Canada, Vineland Station Ontario (Canada). Pest Management Research Centre; Bryant, D.W.; McCarry, B.E. [McMaster Univ., Hamilton, Ontario (Canada)
1998-11-15
In aquatic systems there is considerable transport of organic contaminants on suspended particles that act as carriers and influence the redistribution, bioavailability, and ultimate fate of contaminants. Using methodology not previously applied to the analysis of lake water, the authors demonstrate that polycyclic aromatic hydrocarbons (PAH) in Hamilton Harbor are predominantly sorbed to suspended flocs. Techniques employed were as follows: (i) differential cascade sedimentation and centrifugation to separate suspended particles; (ii) scanning transmission electron microscopy and energy-dispersive spectroscopy to identify flocs and individual particles in the size range of 10{sup {minus}3}--10{sup 3} {micro}m; (iii) gas chromatography-mass spectrometry to identify PAH in extracts prepared from size classes. Heterogeneous flocs larger than 20 {micro}m accounted for roughly 98% of phenanthrene binding, 89% of fluoranthene binding, and 85% of pyrene binding.
The list of tantalum lines for wavelengths calibration of the Hamilton echelle-spectrograph
Pakhomov, Yu V
2015-01-01
We present solution of the problem of wavelength calibration for Hamilton Echelle spectrograph using hollow cathode lamp, which was operated at Lick Observatory Shane telescope before June 9, 2011. The spectrum of the lamp claimed to be thorium-argon, contains, in addition to the lines of thorium and argon, a number of the unrecognized lines identified by us with tantalum. Using atomic data for measured lines of tantalum and thorium, we estimated the temperature of the gas in the lamp as T=3120+/-60 K. From the atomic line database VALD3 we selected all lines of TaI and TaII which can be seen in the spectrum of the lamp and compiled a list for the use in the processing of spectral observations. We note a limitation of the accuracy of calibration due to the influence of the hyperfine line splitting.
Initialization of the Shooting Method via the Hamilton-Jacobi-Bellman Approach
Cristiani, Emiliano
2009-01-01
The aim of this paper is to investigate from the numerical point of view the possibility of coupling the Hamilton-Jacobi-Bellman (HJB) equation and Pontryagin's Minimum Principle (PMP) to solve some control problems. A rough approximation of the value function computed by the HJB method is used to obtain an initial guess for the PMP method. The advantage of our approach over other initialization techniques (such as continuation or direct methods) is to provide an initial guess close to the global minimum. Numerical tests involving multiple minima, discontinuous control, singular arcs and state constraints are considered. The CPU time for the proposed method is less than four minutes up to dimension four, without code parallelization.
Probabilistic formulation of estimation problems for a class of Hamilton-Jacobi equations
Hofleitner, Aude
2012-12-01
This article presents a method for deriving the probability distribution of the solution to a Hamilton-Jacobi partial differential equation for which the value conditions are random. The derivations lead to analytical or semi-analytical expressions of the probability distribution function at any point in the domain in which the solution is defined. The characterization of the distribution of the solution at any point is a first step towards the estimation of the parameters defining the random value conditions. This work has important applications for estimation in flow networks in which value conditions are noisy. In particular, we illustrate our derivations on a road segment with random capacity reductions. © 2012 IEEE.
Hamilton-Jacobi formalism for inflation with non-minimal derivative coupling
Sheikhahmadi, Haidar; Saridakis, Emmanuel N.; Aghamohammadi, Ali; Saaidi, Khaled
2016-10-01
In inflation with nonminimal derivative coupling there is not a conformal transformation to the Einstein frame where calculations are straightforward, and thus in order to extract inflationary observables one needs to perform a detailed and lengthy perturbation investigation. In this work we bypass this problem by performing a Hamilton-Jacobi analysis, namely rewriting the cosmological equations considering the scalar field to be the time variable. We apply the method to two specific models, namely the power-law and the exponential cases, and for each model we calculate various observables such as the tensor-to-scalar ratio, and the spectral index and its running. We compare them with 2013 and 2015 Planck data, and we show that they are in a very good agreement with observations.
Holographic renormalization and Ward identities with the Hamilton-Jacobi method
Martelli, Dario E-mail: d.martelli@qmul.ac.uk; Mueck, Wolfgang E-mail: mueck@na.infn.it
2003-03-24
A systematic procedure for performing holographic renormalization, which makes use of the Hamilton-Jacobi method, is proposed and applied to a bulk theory of gravity interacting with a scalar field and a U(1) gauge field in the Stueckelberg formalism. We describe how the power divergences are obtained as solutions of a set of 'descent equations' stemming from the radial Hamiltonian constraint of the theory. In addition, we isolate the logarithmic divergences, which are closely related to anomalies. The method allows to determine also the exact one-point functions of the dual field theory. Using the other Hamiltonian constraints of the bulk theory, we derive the Ward identities for diffeomorphisms and gauge invariance. In particular, we demonstrate the breaking of U(1){sub R} current conservation, recovering the holographic chiral anomaly recently discussed in and.
Hamilton-Jacobi method for molecular distribution function in a chemical oscillator
Nakanishi, Hiizu; Sakaue, Takahiro; Wakou, Jun'ichi
2013-12-01
Using the Hamilton-Jacobi method, we solve chemical Fokker-Planck equations within the Gaussian approximation and obtain a simple and compact formula for a conditional probability distribution. The formula holds in general transient situations, and can be applied not only to a steady state but also to an oscillatory state. By analyzing the long time behavior of the solution in the oscillatory case, we obtain the phase diffusion constant along the periodic orbit and the steady distribution perpendicular to it. A simple method for numerical evaluation of these formulas are devised, and they are compared with Monte Carlo simulations in the case of Brusselator as an example. Some results are shown to be identical to previously obtained expressions.
Hawking radiation from a Vaidya black hole by Hamilton-Jacobi method
Ding, Han; Liu, Wen-Biao
2011-03-01
Using the Hamilton-Jacobi method, Hawking radiation from the apparent horizon of a dynamical Vaidya black hole is calculated. The black hole thermodynamics can be built successfully on the apparent horizon. If a relativistic perturbation is given to the apparent horizon, a similar calculation can also lead to a purely thermal spectrum, which corresponds to a modified temperature from the former. The first law of thermodynamics can also be constructed successfully at a new supersurface which has a small deviation from the apparent horizon. When the event horizon is thought as such a deviation from the apparent horizon, the expressions of the characteristic position and temperature are consistent with the previous result that asserts that thermodynamics should be built on the event horizon. It is concluded that the thermodynamics should be constructed on the apparent horizon exactly while the event horizon thermodynamics is just one of the perturbations near the apparent horizon.
Hawking radiation of Reissner-Nordstrom-de Sitter black hole by Hamilton-Jacobi method
Hossain, M Ilias
2013-01-01
In Refs. (M. Atiqur Rahman, M. Ilias Hossain (2012) Phys. Lett. B {\\bf 712} 1), we have developed Hamilton-Jacobi method for dynamical spacetime and discussed Hawking radiation of Schwarzschild-de Sitter black hole by massive particle tunneling method. In this letter, we have investigated the hawking purely thermal and nonthermal radiations of Reissner-Nordstr\\"{o}m-de Sitter (RNdS) black hole. We have considered energy and angular momentum as conserved and shown that the tunneling rate is related to the change of Bekenstein-Hawking entropy and the derived emission spectrum deviates from the pure thermal spectrum. The results we have obtained for RNdS black hole is also in accordance with Parikh and Wilczek\\rq s opinion and recovered the new result for Hawking radiation of RNdS black hole.
Back-Reaction of Black Hole Radiation from Hamilton-Jacobi Method
Ding, Chikun
2013-10-01
In the frame of Hamilton-Jacobi method, the back-reactions of the radiating particles together with the total entropy change of the whole system are investigated. The emission probability from this process is found to be equivalent to the null geodesic method. However its physical picture is more clear: the negative energy one of a virtual particle pair is absorbed by the black hole, resulting in the temperature, electric potential and angular velocity increase; then the black hole amount of heat, electric charge and angular momentum can spontaneously transfer to the positive energy particle; when obtaining enough energy, it can escape away to infinity, visible to distant observers. And this method can be applied to any sort of horizons and particles without a specific choice of (regular-across-the-horizon) coordinates.
The classical limit of minimal length uncertainty relation: revisit with the Hamilton-Jacobi method
Guo, Xiaobo; Wang, Peng; Yang, Haitang
2016-05-01
The existence of a minimum measurable length could deform not only the standard quantum mechanics but also classical physics. The effects of the minimal length on classical orbits of particles in a gravitation field have been investigated before, using the deformed Poisson bracket or Schwarzschild metric. In this paper, we first use the Hamilton-Jacobi method to derive the deformed equations of motion in the context of Newtonian mechanics and general relativity. We then employ them to study the precession of planetary orbits, deflection of light, and time delay in radar propagation. We also set limits on the deformation parameter by comparing our results with the observational measurements. Finally, comparison with results from previous papers is given at the end of this paper.
On a Lagrange-Hamilton formalism describing position and momentum uncertainties
Schuch, Dieter
1993-01-01
According to Heisenberg's uncertainty relation, in quantum mechanics it is not possible to determine, simultaneously, exact values for the position and the momentum of a material system. Calculating the mean value of the Hamiltonian operator with the aid of exact analytic Gaussian wave packet solutions, these uncertainties cause an energy contribution additional to the classical energy of the system. For the harmonic oscillator, e.g., this nonclassical energy represents the ground state energy. It will be shown that this additional energy contribution can be considered as a Hamiltonian function, if it is written in appropriate variables. With the help of the usual Lagrange-Hamilton formalism known from classical particle mechanics, but now considering this new Hamiltonian function, it is possible to obtain the equations of motion for position and momentum uncertainties.
Closed circle DNA algorithm of change positive-weighted Hamilton circuit problem
Zhou Kang; Tong Xiaojun; Xu Jin
2009-01-01
Chain length of closed circle DNA is equal. The same closed circle DNA's position corresponds to different recognition sequence, and the same recognition sequence corresponds to different foreign DNA segment, so closed circle DNA computing model is generalized. For change positive-weighted Hamilton circuit problem, closed circle DNA algorithm is put forward. First, three groups of DNA encoding are encoded for all arcs, and deck groups are designed for all vertices. All possible solutions axe composed. Then, the feasible solutions axe filtered out by using group detect experiment, and the optimization solutions are obtained by using group insert experiment and electrophoresis experiment. Finally, all optimization solutions are found by using detect experiment. Complexity of algorithm is concluded and validity of DNA algorithm is explained by an example. Three dominances of the closed circle DNA algorithm are analyzed, and characteristics and dominances of group delete experiment axe discussed.
Hamilton-Jacobi formalism for inflation with non-minimal derivative coupling
Sheikhahmadi, Haidar; Aghamohammadi, Ali; Saaidi, Khaled
2016-01-01
In inflation with nonminimal derivative coupling there is not a conformal transformation to the Einstein frame where calculations are straightforward, and thus in order to extract inflationary observables one needs to perform a detailed and lengthy perturbation investigation. In this work we bypass this problem by performing a Hamilton-Jacobi analysis, namely rewriting the cosmological equations considering the scalar field to be the time variable. We apply the method to two specific models, namely the power-law and the exponential cases, and for each model we calculate various observables such as the tensor-to-scalar ratio, and the spectral index and its running. We compare them with 2013 and 2015 Planck data, and we show that they are in a very good agreement with observations.
Solutions to estimation problems for scalar hamilton-jacobi equations using linear programming
Claudel, Christian G.
2014-01-01
This brief presents new convex formulations for solving estimation problems in systems modeled by scalar Hamilton-Jacobi (HJ) equations. Using a semi-analytic formula, we show that the constraints resulting from a HJ equation are convex, and can be written as a set of linear inequalities. We use this fact to pose various (and seemingly unrelated) estimation problems related to traffic flow-engineering as a set of linear programs. In particular, we solve data assimilation and data reconciliation problems for estimating the state of a system when the model and measurement constraints are incompatible. We also solve traffic estimation problems, such as travel time estimation or density estimation. For all these problems, a numerical implementation is performed using experimental data from the Mobile Century experiment. In the context of reproducible research, the code and data used to compute the results presented in this brief have been posted online and are accessible to regenerate the results. © 2013 IEEE.
Shuang XING
2015-06-01
Full Text Available Objective To explore the effect of the administration time of HS6101 on hematopoietic recovery in ICR mice injured by cyclophosphamide (CTX. Methods One hundred and three male ICR mice were divided into 4 groups: CTX control, HS6101 prevention, HS6101 treatment, and HS6101 prevention+treatment groups. CTX was intraperitoneally injected into the ICR mice at a dose of 100mg/(kg.d for three consecutive days to establish a chemotherapeutics-injured model. HS6101 at a dose of 27μg/mouse in 0.2ml was subcutaneously injected into the mice 1h before the first administration of CTX in HS6101-prevention group, 1h after the last administration of CTX in HS6101 treatment group, and both at 1h before the first administration and 1h after the last administration of CTX in HS6101 prevention + treatment group. Physiological saline was subcutaneously injected into the mice in CTX control group (0.2ml/mouse. 10μl peripheral blood was collected from the caudal vein for WBC, neutrophil lymphocyte, RBC and platelet counts on day -1, 3, 5, 7, 9, 11, 13, 15, 17 with the MEK-7222K cell analyzer, and the cell count was compared between HS6101 treatment mice and CTX control mice. Another 30 male ICR mice were used for bone marrow colony forming unit (CFU assay and bone marrow histopathological examination, and they were assigned into normal control, CTX control, HS6101 prevention, HS6101treatment and HS6101 prevention + treatment groups (each n=6. On the day 4 and day 9 after CTX injection, mice were sacrificed and bone marrow cells were collected from the left femur for mononuclear cell (MNC isolation. 1×104 MNCs were planted in 1.0ml mouse CFU culture medium M3434 and cultured in incubator with the temperature of 37℃, and 5% CO2 for 7 days. After that, granulocyte macrophage-colony-forming unit (GM-CFU, megakaryocyte colony forming unit (MK-CFU, mixture-colony-forming unit (Mix-CFU, burst-forming unit-erythroid (BFU-E and colony-forming unit-erythroid (CFU
Packing density of HS(CH2)(n)COOH self-assembled monolayers.
Snow, A W; Jernigan, G G; Ancona, M G
2011-12-01
Self-assembled monolayers (SAMs) of HS(CH(2))(n)COOH, n = 5, 10, 15 deposited from ethanol solution onto gold are prepared by five approaches, and their packing densities are evaluated by X-ray photoelectron spectroscopy (XPS) measurements. The five approaches are: (1) direct deposition; (2) acetic-acid-assisted deposition; (3) butyl-amine-assisted deposition; (4) displacement of a preformed HS(CH(2))(n)CH(3) (n = 5, 10, 15) SAMs; and (5) co-deposition with HS(CH(2))(n)CH(3) (n = 5, 10, 15). Packing density metrics are calculated from measurements of SAM and substrate photoemission intensities and their attenuations by two methods. In one case the attenuated photoemissions are expressed as a ratio relative to comparable measurements on an experimental HS(CH(2))(n)CH(3) model system. In the other case a new method is introduced where a calculated attenuation based on theoretical random coil and extended chain models is used as the reference to determine a packing density fraction. Packing densities are also correlated with the S2p(Au-bonded):Au4f peak area ratios and with shifts in the C1s binding energies. SAMs prepared by the direct deposition are a partial multilayer where a second molecular layer is physisorbed onto the SAM and not removable by solvent washing. The addition of acetic acid to the deposition solution disrupts dimer associations of HS(CH(2))(n)COOH in solution and at the surface of the monolayer and yields the most ordered monolayer with the highest density of -COOH groups. The addition of butyl amine results in a labile ammonium carbonate ion pair formation but results in a lower packing density in the SAM. The displacement of the preformed HS(CH(2))(n)CH(3) SAM and the co-deposition of HS(CH(2))(n)CH(3) with HS(CH(2))(n)COOH result in SAMs with little incorporation of the -COOH component.
PHOTOMETRIC ANALYSIS OF HS Aqr, EG Cep, VW LMi, AND DU Boo
Djurasevic, G.; Latkovic, O. [Astronomical Observatory, Volgina 7, 11000 Belgrade (Serbia); Bastuerk, Oe.; Y Latin-Small-Letter-Dotless-I lmaz, M. [Astronomy and Space Sciences Research and Application Center, Ankara University, TR-06837 Ahlatl Latin-Small-Letter-Dotless-I bel, Ankara (Turkey); Cal Latin-Small-Letter-Dotless-I skan, S.; Senavc Latin-Small-Letter-Dotless-I , H. V.; K Latin-Small-Letter-Dotless-I l Latin-Small-Letter-Dotless-I coglu, T.; Ekmekci, F. [Department of Astronomy and Space Sciences, Faculty of Science, Ankara University, TR-06100 Tandogan, Ankara (Turkey); Tanr Latin-Small-Letter-Dotless-I verdi, T., E-mail: olivia@aob.rs [Department of Physics, Faculty of Arts and Sciences, Nigde University, 51240 Nigde (Turkey)
2013-03-15
We analyze new multicolor light curves for four close late-type binaries: HS Aqr, EG Cep, VW LMi, and DU Boo, in order to determine the orbital and physical parameters of the systems and estimate the distances. The analysis is done using the modeling code of G. Djurasevic, and is based on up-to-date measurements of spectroscopic elements. All four systems have complex, asymmetric light curves that we model by including bright or dark spots on one or both components. Our findings indicate that HS Aqr and EG Cep are in semi-detached, while VW LMi and DU Boo are in overcontact configurations.
Respiratory medicine at McMaster University, Hamilton, Ontario: 1968 to 2013
Jones, Norman L; O’Byrne, Paul M
2014-01-01
The medical school at McMaster University (Hamilton, Ontario) was conceived in 1965 and admitted the first class in 1969. John Evans became the founding Dean and he invited Moran Campbell to be the first Chairman of the Department of Medicine. Moran Campbell, already a world figure in respiratory medicine and physiology, arrived at McMaster in September 1968, and he invited Norman Jones to be Coordinator of the Respiratory Programme. At that time, Hamilton had a population of 300,000, with two full-time respirologists, Robert Cornett at the Hamilton General Hospital and Michael Newhouse at St Joseph’s Hospital. From the clinical perspective, the aim of the Respiratory Programme was to develop a network approach to clinical problems among the five hospitals in the Hamilton region, with St Joseph’s Hospital serving as a regional referral centre, and each hospital developing its own focus: intensive care and burns units at the Hamilton General Hospital; cancer at the Henderson (later Juravinski) Hospital; tuberculosis and rehabilitation at the Chedoke Hospital; pediatrics and neonatal intensive care at the McMaster University Medical Centre; and community care at the Joseph Brant Hospital in Burlington (Ontario). The network provided an ideal base for a specialty residency program. There was also the need to establish viable research. These objectives were achieved through collaboration, support of hospital administration, and recruitment of clinicians and faculty, mainly from our own trainees and research fellows. By the mid-1970s the respiratory group numbered more than 25; outpatient clinic visits and research had grown beyond our initial expectations. The international impact of the group became reflected in the clinical and basic research endeavours. ASTHMA: Freddy Hargreave and Jerry Dolovich established methods to measure airway responsiveness to histamine and methacholine. Allergen inhalation was shown to increase airway responsiveness for several weeks
梁安玉
2014-01-01
目的：通过分析同一血液标本中超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)检测结果及出现此结果的原因，从而为儿科临床医生诊治疾病提供有力的依据。方法：选取2376例患儿同一血液标本同时测定hs-CRP、WBC，对测定结果进行比较分析。结果：hs-CRP升高占63.8%，WBC升高占39.4%，hs-CRP和WBC均升高占29.8%，hs-CRP和WBC均正常占22.1%，hs-CRP升高而WBC正常占26.1%，hs-CRP升高而WBC降低占7.9%；hs-CRP正常而WBC降低占4.5%；hs-CRP正常而WBC升高占9.6%。结论：hs-CRP和白细胞均可作为感染的判断指标， hs-CRP更优于白细胞，hs-CRP和白细胞可出现各种不同的结果，两者结合判断更有利于患儿疾病的诊治。
Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching.
Shah, Mita M; Sakurai, Hiroyuki; Sweeney, Derina E; Gallegos, Thomas F; Bush, Kevin T; Esko, Jeffrey D; Nigam, Sanjay K
2010-03-15
Heparan sulfate proteoglycans (HSPGs) are central modulators of developmental processes likely through their interaction with growth factors, such as GDNF, members of the FGF and TGFbeta superfamilies, EGF receptor ligands and HGF. Absence of the biosynthetic enzyme, heparan sulfate 2-O-sulfotransferase (Hs2st) leads to kidney agenesis. Using a novel combination of in vivo and in vitro approaches, we have reanalyzed the defect in morphogenesis of the Hs2st(-)(/)(-) kidney. Utilizing assays that separately model distinct stages of kidney branching morphogenesis, we found that the Hs2st(-/-) UB is able to undergo branching and induce mesenchymal-to-epithelial transformation when recombined with control MM, and the isolated Hs2st null UB is able to undergo branching morphogenesis in the presence of exogenous soluble pro-branching growth factors when embedded in an extracellular matrix, indicating that the UB is intrinsically competent. This is in contrast to the prevailing view that the defect underlying the renal agenesis phenotype is due to a primary role for 2-O sulfated HS in UB branching. Unexpectedly, the mutant MM was also fully capable of being induced in recombination experiments with wild-type tissue. Thus, both the mutant UB and mutant MM tissue appear competent in and of themselves, but the combination of mutant tissues fails in vivo and, as we show, in organ culture. We hypothesized a 2OS-dependent defect in the mutual inductive process, which could be on either the UB or MM side, since both progenitor tissues express Hs2st. In light of these observations, we specifically examined the role of the HS 2-O sulfation modification on the morphogenetic capacity of the UB and MM individually. We demonstrate that early UB branching morphogenesis is not primarily modulated by factors that depend on the HS 2-O sulfate modification; however, factors that contribute to MM induction are markedly sensitive to the 2-O sulfation modification. These data suggest that key
Manuel, R.; Gorissen, M.; Stokkermans, M.; Zethof, J.; Ebbesson, L.O.E.; Vis, van de J.W.; Flik, G.; Bos, van den R.
2015-01-01
The inhibitory avoidance paradigm allows the study of mechanisms underlying learning and memory formation in zebrafish (Danio rerio Hamilton). For zebrafish, the physiology and behavior associated with this paradigm are as yet poorly understood. We therefore assessed the effects of environmental enr
Fitzpatrick, P. M.; Harmon, G. R.; Liu, J. J. F.; Cochran, J. E.
1974-01-01
The formalism for studying perturbations of a triaxial rigid body within the Hamilton-Jacobi framework is developed. The motion of a triaxial artificial earth satellite about its center of mass is studied. Variables are found which permit separation, and the Euler angles and associated conjugate momenta are obtained as functions of canonical constants and time.
Sakamoto, Noboru; Schaft, Arjan J. van der
2007-01-01
In this paper, an analytical approximation approach for the stabilizing solution of the Hamilton-Jacobi equation using stable manifold theory is proposed. The proposed method gives approximated flows on the stable manifold of the associated Hamiltonian system and provides approximations of the
Sakamoto, Noboru; Schaft, Arjan J. van der
2007-01-01
In this paper, an analytical approximation approach for the stabilizing solution of the Hamilton-Jacobi equation using stable manifold theory is proposed. The proposed method gives approximated flows on the stable manifold of the associated Hamiltonian system and provides approximations of the stabl
Cardaliaguet, Pierre
2008-01-01
We investigate the regularity of solutions of first order Hamilton-Jacobi equation with super linear growth in the gradient variable. We show that the solutions are locally H\\"older continuous with H\\"older exponent depending only on the growth of the Hamiltonian. The proof relies on a reverse H\\"older inequality.
2011-12-15
... Energy Regulatory Commission Brian Hamilton v. El Paso Natural Gas, El Paso Western Pipelines; Notice Announcing Docket Number Change On December 2, 2011, the Commission issued a notice in docket number RP12-220... docket number, RP12-220-000 and give the proceeding a new docket number. This notice changes the...
Nicolaidis, Mary; Sica, Michael
The major goal of Project SPEED (at Fort Hamilton High School, Brooklyn, New York) was dropout prevention. In its first year of operation, 1982-83, the project provided English as a Second Language (ESL) instruction, bilingual instruction in basic skills required for graduation, and guidance services to approximately 300 limited English proficient…
THE CAUCHY PROBLEM OF NONLINEAR SCHR(O)DINGER-BOUSSINESQ EQUATIONS IN Hs(Rd)
Han Yongqian
2005-01-01
In this paper, the local well posedness and global well posedness of solutions for the initial value problem (IVP) of nonlinear Schrodinger-Boussinesq equations is considered in Hs(Rd) by resorting Besov spaces, where real number s ≥ 0.
Genomic sequence of Campylobacter jejuni subsp. jejuni HS:19 Penner serotype reference strain RM3420
C.T. Parker (Craig); Huynh, S. (Steven); A.P. Heikema (Astrid)
2017-01-01
textabstractCampylobacter jejuni subsp. jejuni infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). Penner serotype HS:19 is among several capsular types shown to be markers for GBS. This study describes the genome of C.
Baseline distribution and correlation analysis of hsCRP in an insurance applicant population.
Krause, Kenneth J; Williams, David S; White, Nancy
2008-01-01
Many clinical studies have shown that baseline levels of high sensitivity C-reactive protein (hsCRP) in apparently healthy men and women are highly predictive of future risk of heart attack, stroke, sudden cardiac death, and the development of peripheral arterial disease. This paper presents an analysis of the baseline characteristics of our prospective study cohort. The intent of our prospective study is to determine whether hsCRP can be used to better classify risk for life insurance applicants already at risk for cardiovascular events, as well as those who are not. The possibility that low levels of hsCRP levels in otherwise healthy applicants might be associated with more favorable cardiovascular risk could allow this test to be used to more precisely stratify risk in the standard-or-better underwriting classifications. In this preliminary analysis, high sensitivity CRP appears to be weakly correlated with BMI, and perhaps triglyceride level in this cohort of insurance applicants. Somewhat surprisingly, in contrast to many published reports, hsCRP was not found to be correlated with other lipid measures (TC, HDL, LDL), dysmetabolic markers or smoking classification during the underwriting process. We plan to analyze mortality results as they evolve in the future.
The Role of the Media in South African Construction Health and Safety (H&S
John Smallwood
2012-11-01
Full Text Available A large number of fatalities and injuries occur in the South African construction industry. Traditionally, the print media have dedicated editorial, published news, articles and letters, and have exposed abusive or non-conforming conditions and practices in terms of H&S. Literature also indicates that the print media can influence and has an impact on H&S.Given the level of fatalities and injuries and the potential role of the print media, a postal survey was conducted among editors of construction and related magazines. Findings indicate that: the print media do contribute to and play a role in construction H&S; industry has the capacity and needs to promote H&S on a wider basis; there is a need to improve construction H&S; to a degree, editors are aware of what constitutes unsafe acts and unsafe conditions, and the print media can play an increased role through the review of articles, advertisements, advertorial, editorial and phototgraphs to prevent the depiction of unhealthy and unsafe practices and conditions
Synthetic Human β-Globin 5'HS2 Constructs Function as Partially Active Locus Control Regions.
J. Ellis (James); D. Talbot; N.O. Dillon (Niall); F.G. Grosveld (Frank)
1993-01-01
textabstractTransgenes linked to the beta-globin locus control region (LCR) are transcribed in a copy-dependent manner that is independent of the integration site. It has previously been shown that the LCR 5'HS2 region does not require its NF-E2 dimer binding site for LCR activity. In this paper we
Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells.
Lee, Hye Min; Moon, Aree
2016-01-01
Amygdalin, D-mandelonitrile-β-D-glucoside-6-β-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor agent against breast cancer cells is not clear. The present study aimed to investigate the effect of amygdalin on the proliferation of human breast cancer cells. Here, we show that amygdalin exerted cytotoxic activities on estrogen receptors (ER)-positive MCF7 cells, and MDA-MB-231 and Hs578T triple-negative breast cancer (TNBC) cells. Amygdalin induced apoptosis of Hs578T TNBC cells. Amygdalin downregulated B-cell lymphoma 2 (Bcl-2), upregulated Bcl-2-associated X protein (Bax), activated of caspase-3 and cleaved poly ADP-ribose polymerase (PARP). Amygdalin activated a pro-apoptotic signaling molecule p38 mitogen-activated protein kinases (p38 MAPK) in Hs578T cells. Treatment of amygdalin significantly inhibited the adhesion of Hs578T cells, in which integrin α5 may be involved. Taken together, this study demonstrates that amygdalin induces apoptosis and inhibits adhesion of breast cancer cells. The results suggest a potential application of amygdalin as a chemopreventive agent to prevent or alleviate progression of breast cancer, especially TNBC.
Kim Vriens
Full Text Available Plant defensins are small, cysteine-rich peptides with antifungal activity against a broad range of yeast and fungi. In this study we investigated the antibiofilm activity of a plant defensin from coral bells (Heuchera sanguinea, i.e. HsAFP1. To this end, HsAFP1 was heterologously produced using Pichia pastoris as a host. The recombinant peptide rHsAFP1 showed a similar antifungal activity against the plant pathogen Fusarium culmorum as native HsAFP1 purified from seeds. NMR analysis revealed that rHsAFP1 consists of an α-helix and a triple-stranded antiparallel β-sheet stabilised by four intramolecular disulfide bonds. We found that rHsAFP1 can inhibit growth of the human pathogen Candida albicans as well as prevent C. albicans biofilm formation with a BIC50 (i.e. the minimum rHsAFP1 concentration required to inhibit biofilm formation by 50% as compared to control treatment of 11.00 ± 1.70 μM. As such, this is the first report of a plant defensin exhibiting inhibitory activity against fungal biofilms. We further analysed the potential of rHsAFP1 to increase the activity of the conventional antimycotics caspofungin and amphotericin B towards C. albicans. Synergistic effects were observed between rHsAFP1 and these compounds against both planktonic C. albicans cells and biofilms. Most notably, concentrations of rHsAFP1 as low as 0.53 μM resulted in a synergistic activity with caspofungin against pre-grown C. albicans biofilms. rHsAFP1 was found non-toxic towards human HepG2 cells up to 40 μM, thereby supporting the lack of a general cytotoxic activity as previously reported for HsAFP1. A structure-function study with 24-mer synthetic peptides spanning the entire HsAFP1 sequence revealed the importance of the γ-core and its adjacent regions for HsAFP1 antibiofilm activity. These findings point towards broad applications of rHsAFP1 and its derivatives in the field of antifungal and antibiofilm drug development.
Runzhou Ni; Lei Yang; Mingbing Xiao; Feng Li; Cuihua Lu
2006-01-01
OBJECTIVE To investigate the clinical value of hepatoma-specific alpha-fetoprotein (HS-AFP) and gamma-glutamyltransferase Ⅱ (GGT Ⅱ) for judgment of postoperative prognosis of patients with hepatocellular carcinoma (HCC).METHODS HS-AFP was separated and determined using native polyacrylamide electrophoresis with a discontinuous buffer system and Western blots. GGT Ⅱ was separated with native polyacrylamide electrophoresis with a discontinuous buffer system and detected by enzyme staining. Forty cases with HCC underwent serial determination of HS-AFP and GGT Ⅱ before and after radical excision. The correlations were analyzed between the two indices and survival time.RESULTS In the 40 cases with HCC, before radical excision the positive rates of HS-AFP and GGT Ⅱ were 57.5% and 67.5% respectively, with the positive rate of combined HS-AFP and GGT Ⅱ reaching 80.0%. After operation, the recurrence and metastasis rate in the groups with positive HS-AFP and GGT Ⅱ were 90.9% and 58.8% respectively, while in the groups with negative HS-AFP and GGT Ⅱ the rates were 20.7% and 26.1% respectively. Recurrence and metastasis occurred in all cases with both postoperative positive HS-AFP and GGT Ⅱ but only in 9.5% of the cases in whom both postoperative HS-AFP and GGT Ⅱ were negative. Univariate analysis revealed that postoperative HS-AFP and GGT Ⅱ were related to the prognosis in HCC.CONCLUSION Postoperative serum HS-AFP and GGT Ⅱ are very useful in predicting the prognosis of HCC patients.
Shakeel-u- Rehman
2017-05-01
Full Text Available Headspace solid-phase micro extraction (HS-SPME coupled with gas chromatography–mass spectrometry (GC–MS has been used for the chemical analysis of Melissa officinalis (leaves cultivated in Institute Germplasm. The HS-SPME analysis led to the identification of 22 components constituting 99.1% of the total volatile constituents present in the leaves whereas its hydrodistillate led to the identification of 24 volatile constituents constituting 98.1% of the volatile material. The chemical composition of the SPME and hydrodistilled extract of M. officinalis leaves comprised mainly of oxygenated monoterpenes (78.5% and 57.8% respectively and sesquiterpene hydrocarbons (14.9% and 29.7% respectively. The major components identified in the HS-SPME extract were citronellal (31.1%, citronellol (18.3%, β-caryophyllene (12.0%, (E-citral (11.9%, (Z-citral (9.6%, geraniol (3.6%, (Z-β-ocimene (3.1% and 1-octen-3-ol (2.0% whereas hydrodistilled essential oil was rich in (Z-citral (19.6%, β-caryophyllene (13.2%, (E-citral (11.2%, citronellal (10.2%, germacrene-d (8.3%, δ-3-carene (5.0%, 6-methyl-5-hepten-2-one (3.7% and citronellyl acetate (3.7%. The comparative analysis of volatile constituents of M. officinalis leaf extract using HS-SPME and hydrodistillation techniques shows both qualitative as well as quantitative differences. The current study is the first report involving rapid analysis of volatile components of M. officinalis by HS-SPME.
Post-synthetic regulation of HS structure: the yin and yang of the Sulfs in Cancer
Romain R Vives
2014-01-01
Full Text Available Heparan sulfate (HS is a complex polysaccharide that takes part in most major cellular processes, through its ability to bind and modulate a very large array of proteins. These interactions involve saccharide domains of specific sulfation pattern (S-domains, the assembly of which is tightly orchestrated by a highly regulated biosynthesis machinery. Another level of structural control does also take place at the cell surface, where degrading enzymes further modify HS post-synthetically. Amongst them are the Sulfs, a family of extracellular sulfatases (two isoforms in human that catalyze the specific 6-O-desulfation of HS. By targeting HS functional sulfated domains, Sulfs dramatically alter its ligand binding properties, thereby modulating a broad range of signaling pathways. Consequently, Sulfs play major roles during development, as well as in tissue homeostasis and repair. Sulfs have also been associated with many pathologies including cancer, but despite increasing interest, the role of Sulfs in tumor development still remains unclear. Studies have been hindered by a poor understanding of the Sulf enzymatic activities and conflicting data have shown either anti-oncogenic or tumor-promoting effects of these enzymes, depending on the tumor models analyzed. These opposite effects clearly illustrate the fine tuning of HS functions by the Sulfs, and the need to clarify the mechanisms involved. In this review, we will detail the present knowledge on the structural and functional properties of the Sulfs, with a special focus on their implication during tumor progression. Finally, we will discuss attempts and perspectives of using the Sulfs as a biomarker of cancer prognosis and diagnostic and as a target for anti-cancer therapies.
Unstable Angina Pectoris Patients Serum hs-CRP Levels in Clinical Research%不稳定心绞痛患者血清hs-CRP水平临床研究
易慧芳
2014-01-01
Objective Investigate al ergic hs CRP determination in patients with unstable angina pectoris diagnosis value of serum. Methods Choose 60 cases of unstable angina pectoris patients as observation group, In the treatment of day 1, day 15 test hs-CRP concentration in serum, select 60 outpatient patients with stable angina pectoris patients as control group. Results Group of patients with unstable angina pectoris patients serum hs- CRP concentration significantly increased, compared with the control group with very significant dif erence( P<0.05 ) ,Observation group in the treatment of before and after comparison, hs-CRP concentration in serum increased obviously, there are significant dif erences(P<0.05). Conclusion The hs-CRP significantly higher in patients with unstable angina pectoris, has a high diagnostic value.%目的：探讨超敏C反应蛋白( High sensitivity C Reactive Protein,hs-CRP )测定在不稳定心绞痛患者血清中的诊断价值。方法选取60例不稳定心绞痛患者作为观察组,在入院第1d、第15d检测血清中hs-CRP浓度,选取门诊稳定心绞痛患者60例作为对照组。结果不稳定心绞痛患者患者组血清中hs-CRP浓度明显增高,与对照组比较有非常显著性差异(P<0.05),观察组在治疗前、后比较,血清中hs-CRP浓度明显增高,有显著性差异(P<0.05)。结论 hs-CRP在不稳定心绞痛患者中显著增高,有很高的诊断价值。
ROS-Dependent Neuroprotective Effects of NaHS in Ischemia Brain Injury Involves the PARP/AIF Pathway
Qian Yu
2015-07-01
Full Text Available Background/Aims: Stroke is among the top causes of death worldwide. Neuroprotective agents are thus considered as potentially powerful treatment of stroke. Methods: Using both HT22 cells and male Sprague-Dawley rats as in vitro and in vivo models, we investigated the effect of NaHS, an exogenous donor of H2S, on the focal cerebral ischemia-reperfusion (I/R induced brain injury. Results: Administration of NaHS significantly decreased the brain infarcted area as compared to the I/R group in a dose-dependent manner. Mechanistic studies demonstrated that NaHS-treated rats displayed significant reduction of malondialdehyde content, and strikingly increased activity of superoxide dismutases and glutathione peroxidase in the brain tissues compared with I/R group. The enhanced antioxidant capacity as well as restored mitochondrial function are NaHS-treatment correlated with decreased cellular reactive oxygen species level and compromised apoptosis in vitro or in vivo in the presence of NaHS compared with control. Further analysis revealed that the inhibition of PARP-1 cleavage and AIF translocation are involved in the neuroprotective effects of NaHS. Conclusion: Collectively, our results suggest that NaHS has potent protective effects against the brain injury induced by I/R. NaHS is possibly effective through inhibition of oxidative stress and apoptosis.
Liu, Yu-Bin; Ying, Jie; Kuang, Su-Juan; Jin, Hao-Sheng; Yin, Zi; Chang, Liang; Yang, Hui; Ou, Ying-Liang; Zheng, Jiang-Hua; Zhang, Wei-Dong; Li, Chuan-Sheng; Jian, Zhi-Xiang
2015-12-01
To evaluate the effects of preoperative highly sensitive C-reactive protein (Hs-CRP) in serum on the prognostic outcomes of patients with hepatocellular carcinoma (HCC) following hepatic resection in Chinese samples.From January 2004 to December 2008, a total of 624 consecutive HCC patients who underwent hepatic resection were incorporated. Serum levels of Hs-CRP were tested at preoperation via a collection of venous blood samples. Survival analyses adopted the univariate and multivariate analyses.In our study, among the 624 screened HCC patients, 516 patients were eventually incorporated and completed follow-up. Positive correlations were found regarding preoperative serum Hs-CRP level and tumor size, Child-Pugh class, or tumor stage (all P Hs-CRP levels at preoperation (both P Hs-CRP-normal group, the overall survival (OS) and recurrence-free survival rates were evidently decreased in the Hs-CRP-elevated group. Further, preoperative serum Hs-CRP level might be having possible prediction effect regarding survival and recurrence of HCC patients after hepatic section in the multivariate analysis.Preoperative increased serum Hs-CRP level was an independent prognostic indicator in patients with HCC following hepatic resection in Chinese samples.
Alireza Yaghoubi
2015-09-01
Conclusion: The association and correlation between VN, MDA and hs-CRP indicate their involvement in the atherosclerosis process that may lead to progression of CAD. Also, these findings suggested that serum levels of VN, MDA and hs-CRP can help as diagnostic and monitoring markers in CAD patients and as markers of disease severity.
The dependence of the blood level of the oxime HS 6 on the severity of organophosphate poisoning
Wolthuis, O.L.; Clason-van der Wiel, H.J.; Visser, R.P.L.S.
1976-01-01
Atropinised anaesthetised rats were injected i.v. with 4, 6 or 8 x LD50 of the organophosphorous anticholinesterase soman. Subsequent treatment with one dose of HS 6 (100 mg/kg, i.v.) delayed respiratory failure by 1 h or more; a further postponement was obtained when an additional HS 6 infusion was
Kahner, Bryan N; Dorsam, Robert T; Mada, Sripal R; Kim, Soochong; Stalker, Timothy J; Brass, Lawrence F; Daniel, James L; Kitamura, Daisuke; Kunapuli, Satya P
2007-10-01
Collagen activates platelets through an intracellular signaling cascade downstream of glycoprotein VI (GPVI). We have investigated the contribution of hematopoietic lineage cell-specific protein 1 (HS1) downstream of GPVI in platelet activation. Stimulation of GPVI leads to tyrosine phosphorylation of HS1, which is blocked by Src-family kinase inhibitors. Coimmunoprecipitation experiments revealed that HS1 associates with Syk and phosphatidylinositol 3-kinases. HS1-null mice displayed increased bleeding times and increased time to occlusion in the FeCl(3) in vivo thrombosis model compared with their wild-type littermates. In addition, aggregation and secretion responses were diminished in HS1-null mouse platelets after stimulation of GPVI and protease-activated receptor 4 (PAR-4) agonists compared with wild-type littermate mouse platelets. Finally, Akt phosphorylation was diminished after GPVI or PAR-4 stimulation in platelets from HS1-null mice compared with their wild-type littermates. These results demonstrate that phosphorylation of the HS1 protein occurs downstream of GPVI stimulation and that HS1 plays a significant functional role in platelet activation downstream of GPVI and PARs.
Prinsi, Bhakti; Negri, Alfredo S; Espen, Luca; Piagnani, M Claudia
2016-05-25
The somaclonal variant HS, from sweet cherry (Prunus avium L.) 'Hedelfinger' (H), was previously selected for reduced tree vegetative vigor and lesser canopy density. In this work, we compared H and HS fruits at early unripe (green) and full ripe (dark red) stages by biochemical and proteomic approaches. The main biochemical parameters showed that fruit quality was not affected by somaclonal variation. The proteomic analysis identified 39 proteins differentially accumulated between H and HS fruits at the two ripening stages, embracing enzymes involved in several pathways, such as carbon metabolism, cell wall modification, stress response, and secondary metabolism. The evaluation of fruit phenolic composition by mass spectrometry showed that HS sweet cherries have higher levels of procyanidin, flavonol, and anthocyanin compounds. This work provides the first proteomic characterization of fruit ripening in sweet cherry, revealing new positive traits of the HS somaclonal variant.
Analysis of the changes of serum lipid and hs-CRP in patients with subclinical hypothyroidism
Jin-Mian Fan; Dong-Bo Zheng; Zhou-Ping Zhang
2016-01-01
Objective:To analyze changes of serum lipid and hs-CRP levels in patients with subclinical hypothyroidism in order to explore their correlations with TSH level.Methods:A total of 90 patients with subclinical hypothyroidism were included in the study and divided into the mild, moderate, and severe groups according to TSH level with 30 cases in each group; meanwhile, 30 healthy individuals were served as the control groups. The changes of the levels of TSH, serum lipid indicators (TC, TG, HDL-C, LDL-C, ApoA, ApoB, and Lpa), and hs-CRP in the four groups were observed. The correlation of serum lipid and hs-CRP with TSH was analyzed. Results: The levels of TSH, TC, TG, Lpa, and hs-CRP in the subclinical hypothyroidism subgroups were significantly higher than those in the control group. The levels of HDL-C, LDL-C, ApoA, and ApoB in patients with subclinical hypothyroidism were increased when compared with the control group. The levels of HDL-C, LDL-C, and ApoB in the moderate and severe groups were significantly higher than those in the control group. ApoA level in the severe group was significantly higher than that in the control group. LDL-C in the moderate group was significantly higher than that in the mild group, and that in the severe group was significantly higher than that in the moderate group. ApoB level in the severe group was significantly higher than that in the mild group. Spearman correlation analysis showed that TC, TG, LDL-C, ApoB, Lpa, and hs-CRP were positively correlated with TSH level, while HDL-C and ApoA had no correlation with TSH level.Conclusions:The levels of serum lipid and hs-CRP are abnormally elevated in patients with subclinical hypothyroidism, and are gradually increased along with the disease progression, which is closely associated with TSH level.
hsCRP in pre-hypertension and hypertension: a prospective study in Southern Asian region
Satwika Sinha
2014-08-01
Full Text Available Background: Hypertension is turned into a leading cause of non-communicable disease associated mortality and morbidity in both developing as well as developed world. Hypertension is reported to be the fourth contributor to premature death in developed countries and the seventh in developing countries. In the regard of early diagnosis and better prognosis, the concept of pre-hypertension, defined as a systolic blood pressure of 120-139 mmHg and/or a diastolic blood pressure of 80-89 mmHg was introduced as the new guideline for the management of blood pressure by the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure (JNC-7. Among various other factors inflammation may be a causative factor for development of Hypertension But the association is not very clear. Accordingly, we have designed our study to find any association of hsCRP with pre-hypertension and hypertension so that early prevention and control can help to avoid or delay the grave outcome and complications of hypertension. Methods: A total of 37 hypertensives, 30 pre-hypertensives and 31 age and sex matched healthy control subjects were selected for the study, with consent. Two BP readings were taken five minutes apart, on both arms, with a mercury sphygmomanometer. The estimation of serum hsCRP was done on XL-600 automatic analyzer with the kit (Erba Mannheim based on the measurement of antigen-antibody reaction by the end-point method. Results: There is significant difference in systemic and diastolic blood pressure and hsCRP in between group study. In pre-hypertensive group hsCRP is correlated with diastolic blood pressure. Conclusion: Our results suggest a correlation exists between hsCRP and hypertension more significantly with pre-hypertension. So estimation of serum hsCRP can be a good diagnostic as well as prognostic marker in diagnosing pre-hypertensives and prevent the occurance of hypertension and cardio
Canonical equations of Hamilton for the nonlinear Schr\\"{o}dinger equation
Liang, Guo; Ren, Zhanmei
2013-01-01
We define two different systems of mathematical physics: the second-order differential system (SODS) and the first-order differential system (FODS). The Newton's second law of motion and the nonlinear Schr\\"{o}dinger equation (NLSE) are the exemplary SODS and FODS, respectively. We obtain a new kind of canonical equations of Hamilton (CEH), which are of some kind of symmetry in form and are formally different with the conventional CEH without symmetry [H. Goldstein, C. Poole, J. Safko, Classical Mechanics, third ed., Addison-Wesley, 2001]. We also prove that the number of the CEHs is equal to the number of the generalized coordinates for the FODS, but twice the number of the generalized coordinates for the SODS. We show that the FODS can only be expressed by the new CEH, but do not by the conventional CEH, while the SODS can be done by both the new and the conventional CEHs. As an example, we prove that the nonlinear Schr\\"{o}dinger equation can be expressed with the new CEH in a consistent way.
Canonical equations of Hamilton for the nonlinear Schrödinger equation
Liang, Guo; Guo, Qi; Ren, Zhanmei
2015-09-01
We define two different systems of mathematical physics: the second order differential system (SODS) and the first order differential system (FODS). The Newton's second law of motion and the nonlinear Schrödinger equation (NLSE) are the exemplary SODS and FODS, respectively. We obtain a new kind of canonical equations of Hamilton (CEH), which exhibit some kind of symmetry in form and are formally different from the conventional CEH without symmetry [H. Goldstein, C. Poole, J. Safko, Classical Mechanics, third ed., Addison- Wesley, 2001]. We also prove that the number of the CEHs is equal to the number of the generalized coordinates for the FODS, but twice the number of the generalized coordinates for the SODS. We show that the FODS can only be expressed by the new CEH, but not introduced by the conventional CEH, while the SODS can be done by both the new and the conventional CEHs. As an example, we prove that the nonlinear Schrödinger equation can be expressed with the new CEH in a consistent way.
Videla, Nelson [FCFM, Universidad de Chile, Departamento de Fisica, Santiago (Chile)
2017-03-15
In the present work we study the consequences of considering an inflationary universe model in which the Hubble rate has a quasi-exponential dependence in the inflaton field, given by H(φ) = H{sub inf} exp[((φ)/(m{sub p}))/(p(1+(φ)/(m{sub p})))]. We analyze the inflation dynamics under the Hamilton-Jacobi approach, which allows us to consider H(φ), rather than V(φ), as the fundamental quantity to be specified. By comparing the theoretical predictions of the model together with the allowed contour plots in the n{sub s} - r plane and the amplitude of primordial scalar perturbations from the latest Planck data, the parameters charactering this model are constrained. The model predicts values for the tensor-to-scalar ratio r and for the running of the scalar spectral index dn{sub s}/d ln k consistent with the current bounds imposed by Planck, and we conclude that the model is viable. (orig.)
Social determinants of older adults' awareness of community support services in Hamilton, Ontario.
Tindale, J; Denton, M; Ploeg, J; Lillie, J; Hutchison, B; Brazil, K; Akhtar-Danesh, N; Plenderleith, J
2011-11-01
Community support services (CSSs) have been developed in Canada and other Western nations to enable persons coping with health or social issues to continue to live in the community. This study addresses the extent to which awareness of CSSs is structured by the social determinants of health. In a telephone interview conducted in February-March 2006, 1152 community-dwelling older adults (response rate 12.4%) from Hamilton, Ontario, Canada were made to read a series of four vignettes and were asked whether they were able to identify a CSS they may turn to in that situation. Across the four vignettes, 40% of participants did name a CSS as a possible source of assistance. Logistic regression was used to determine factors related to awareness of CSSs. Respondents most likely to have awareness of CSS include the middle-aged and higher-income groups. Being knowledgeable about where to look for information about CSSs, having social support and being a member of a club or voluntary organisations are also significant predictors of awareness of CSSs. Study results suggest that efforts be made to improve the level of awareness and access to CSSs among older adults by targeting their social networks as well as their health and social care providers.
Hamilton-Jacobi Many-Worlds Theory and the Heisenberg Uncertainty Principle
Tipler, Frank J
2010-01-01
I show that the classical Hamilton-Jacobi (H-J) equation can be used as a technique to study quantum mechanical problems. I first show that the the Schr\\"odinger equation is just the classical H-J equation, constrained by a condition that forces the solutions of the H-J equation to be everywhere $C^2$. That is, quantum mechanics is just classical mechanics constrained to ensure that ``God does not play dice with the universe.'' I show that this condition, which imposes global determinism, strongly suggests that $\\psi^*\\psi$ measures the density of universes in a multiverse. I show that this interpretation implies the Born Interpretation, and that the function space for $\\psi$ is larger than a Hilbert space, with plane waves automatically included. Finally, I use H-J theory to derive the momentum-position uncertainty relation, thus proving that in quantum mechanics, uncertainty arises from the interference of the other universes of the multiverse, not from some intrinsic indeterminism in nature.
Cook, Alana N; Moulden, Heather M; Mamak, Mini; Lalani, Shams; Messina, Katrina; Chaimowitz, Gary
2016-07-14
The Hamilton Anatomy of Risk Management-Forensic Version (HARM-FV) is a structured professional judgement tool of violence risk developed for use in forensic inpatient psychiatric settings. The HARM-FV is used with the Aggressive Incidents Scale (AIS), which provides a standardized method of recording aggressive incidents. We report the findings of the concurrent validity of the HARM-FV and the AIS with widely used measures of violence risk and aggressive acts, the Historical, Clinical, Risk Management-20, Version 3 (HCR-20(V3)) and a modified version of the Overt Aggression Scale. We also present findings on the predictive validity of the HARM-FV in the short term (1-month follow-up periods) for varying severities of aggressive acts. The results indicated strong support for the concurrent validity of the HARM-FV and AIS and promising support for the predictive accuracy of the tool for inpatient aggression. This article provides support for the continued clinical use of the HARM-FV within an inpatient forensic setting and highlights areas for further research. © The Author(s) 2016.
Wave front-ray synthesis for solving the multidimensional quantum Hamilton-Jacobi equation.
Wyatt, Robert E; Chou, Chia-Chun
2011-08-21
A Cauchy initial-value approach to the complex-valued quantum Hamilton-Jacobi equation (QHJE) is investigated for multidimensional systems. In this approach, ray segments foliate configuration space which is laminated by surfaces of constant action. The QHJE incorporates all quantum effects through a term involving the divergence of the quantum momentum function (QMF). The divergence term may be expressed as a sum of two terms, one involving displacement along the ray and the other incorporating the local curvature of the action surface. It is shown that curvature of the wave front may be computed from coefficients of the first and second fundamental forms from differential geometry that are associated with the surface. Using the expression for the divergence, the QHJE becomes a Riccati-type ordinary differential equation (ODE) for the complex-valued QMF, which is parametrized by the arc length along the ray. In order to integrate over possible singularities in the QMF, a stable and accurate Möbius propagator is introduced. This method is then used to evolve rays and wave fronts for four systems in two and three dimensions. From the QMF along each ray, the wave function can be easily computed. Computational difficulties that may arise are described and some ways to circumvent them are presented. © 2011 American Institute of Physics
Study of Finite Elements for Hamilton Systems%Hamilton系统的有限元研究
陈传淼; 汤琼
2011-01-01
该文对Hamilton系统的连续有限元法证明了两个优美的性质:在任何情形m次有限元总是能量守恒的,它对线性系统也是辛的,且对非线性系统每次步进是高精度O(h2m+1)近似辛的.在长时间计算中时空平面上轨道和周期的偏离随时间线性增长.数值实验表明其偏离比其他算法小.%Two nice properties of the continuous finite element method for Hamilton systems are proved as follows: in any case the m-degree finite elements always preserve the energy which is sympletic for linear systems and is approximately sympletic with high accuracy O(h2m+l) in each stepping for nonlinear systems. In long-time computation the deviation of trajectories and their periods in time-space plane will crease linearly with time. Numerical experiments show that their deviations are often smaller than that of other schemes.
Husbandry stress exacerbates mycobacterial infections in adult zebrafish, Danio rerio (Hamilton)
Ramsay, J.M.; Watral, V.; Schreck, C.B.; Kent, M.L.
2009-01-01
Mycobacteria are significant pathogens of laboratory zebrafish, Danio rerio (Hamilton). Stress is often implicated in clinical disease and morbidity associated with mycobacterial infections but has yet to be examined with zebrafish. The aim of this study was to examine the effects of husbandry stressors on zebrafish infected with mycobacteria. Adult zebrafish were exposed to Mycobacterium marinum or Mycobacterium chelonae, two species that have been associated with disease in zebrafish. Infected fish and controls were then subjected to chronic crowding and handling stressors and examined over an 8-week period. Whole-body cortisol was significantly elevated in stressed fish compared to non-stressed fish. Fish infected with M. marinum ATCC 927 and subjected to husbandry stressors had 14% cumulative mortality while no mortality occurred among infected fish not subjected to husbandry stressors. Stressed fish, infected with M. chelonae H1E2 from zebrafish, were 15-fold more likely to be infected than non-stressed fish at week 8 post-injection. Sub-acute, diffuse infections were more common among stressed fish infected with M. marinum or M. chelonae than non-stressed fish. This is the first study to demonstrate an effect of stress and elevated cortisol on the morbidity, prevalence, clinical disease and histological presentation associated with mycobacterial infections in zebrafish. Minimizing husbandry stress may be effective at reducing the severity of outbreaks of clinical mycobacteriosis in zebrafish facilities. ?? 2009 Blackwell Publishing Ltd.
Equation of motion of canonical tensor model and Hamilton-Jacobi equation of general relativity
Chen, Hua; Sato, Yuki
2016-01-01
The canonical tensor model (CTM) is a rank-three tensor model formulated as a totally constrained system in the canonical formalism. The constraint algebra of CTM has a similar structure as that of the ADM formalism of general relativity, and is studied as a discretized model for quantum gravity. In this paper, we analyze the classical equation of motion (EOM) of CTM in a formal continuum limit through a derivative expansion of the tensor up to the forth order, and show that it is the same as the EOM of a coupled system of gravity and a scalar field derived from the Hamilton-Jacobi equation with an appropriate choice of an action. The action contains a scalar field potential of an exponential form, and the system classically respects a dilatational symmetry. We find that the system has a critical dimension, given by six, over which it becomes unstable due to the wrong sign of the scalar kinetic term. In six dimensions, de Sitter spacetime becomes a solution to the EOM, signaling the emergence of a conformal s...
Quantized Hamilton dynamics describes quantum discrete breathers in a simple way.
Igumenshchev, Kirill; Prezhdo, Oleg
2011-08-01
We study the localization of energy in a nonlinear coupled system, exhibiting so-called breather modes, using quantized Hamilton dynamics (QHD). Already at the lowest order, which is only twice as complex as classical mechanics, this simple semiclassical method incorporates quantum-mechanical effects. The transition between the localized and delocalized regimes is instantaneous in classical mechanics, while it is gradual due to tunneling in both quantum mechanics and QHD. In contrast to classical mechanics, which predicts an abrupt appearance of breathers, quantum mechanics and QHD show an alternation of localized and delocalized behavior in the transient region. QHD includes zero-point energy that is reflected in a shifted energy asymptote for the localized states, providing another improvement on the classical perspective. By detailed analysis of the distribution and transfer of energy within classical mechanics, QHD, and quantum dynamics, we conclude that QHD is an efficient approach that accounts for moderate quantum effects and can be used to identify quantum breathers in large nonlinear systems.
Study of invariant surfaces and their break-up by the Hamilton-Jacobi method
Warnock, R.L.; Ruth, R.D.
1986-08-01
A method is described to compute invariant tori in phase space for calssical non-integrable Hamiltonian systems. Our procedure is to solve the Hamilton-Jacobi equation stated as a system of equations for Fourier coefficients of the generating function. The system is truncated to a finite number of Fourier modes and solved numerically by Newton's method. The resulting canonical transformation serves to reduce greatly the non-integrable part of the Hamiltonian. In examples studied to date the convergence properties of the method are excellent, even near chaotic regions and on the separatrices of isolated broad resonances. We propose a criterion for breakup of invariant surfaces, namely the vanishing of the Jacobian of the canonical transformation to new angle variables. By comparison with results from tracking, we find in an example with two nearly overlapping resonances that this criterion can be implemented with sufficient accuracy to determine critical parameters for the breakup ('transition to chaos') to an accuracy of 5 to 10%.
Performance of orangefin labeo, Labeo calbasu (Hamilton 1822 as a component of polyculture system
Bibha Chetia Borah
2014-04-01
Full Text Available This paper deals with the performance of orangefin labeo, Labeo calbasu (Hamilton, 1822 as a component of conventional composite carp culture system. The species was included as 50% substitution to common carp (Cyprinus carpio in view of its omnivorous feeding habit and bottom dwelling nature. The total production was 0.55% higher in the experimental culture (with L. calbasu and Cyprinus carpio than in the control (common carp only. The difference in the production was however not significant statistically. The comparative economics revealed 5.30% higher return from the experimental unit. Comparison of growth pattern and survival rates of other five species of carps indicated that inclusion of L. calbasu did not have any adverse impact on the other carps. Growth rate of other carps was observed to be higher in the experimental set by 0.05% on an average than the control. Calculated profit per hectare was found to be 9.2% higher in experimental plot than in the control. Although the gross production and return in the experimental unit was not significantly higher than the control, the data supported that L. calbasu is compatible to other component species in composite carp culture system and its inclusion will enhance the economic viability of the system.
Ghosh Saroj Kumar
2016-12-01
Full Text Available The morphoanatomy, cellular organization, and surface architecture of the olfactory apparatus in Cirrhinus reba (Hamilton is described using light and scanning electron microscopy. The oval shaped olfactory rosette contained 32 ± 2 primary lamellae on each side of the median raphe, and was lodged on the floor of the olfactory chamber. The olfactory lamellae were basically flat and compactly arranged in the rosette. The olfactory chamber communicated to the outside aquatic environment through inlet and outlet apertures with a conspicuous nasal flap in between. The mid dorsal portion of the olfactory lamellae was characterized by a linguiform process. Sensory and non-sensory regions were distributed separately on each lamella. The sensory epithelium occupied the apical part including the linguiform process, whereas the resting part of the lamella was covered with non-sensory epithelium. The sensory epithelium comprised both ciliated and microvillous receptor cells distinguished by the architecture on their apical part. The non-sensory epithelium possessed mucous cells, labyrinth cells, and stratified epithelial cells with distinctive microridges. The functional importance of the different cells lining the olfactory mucosa was correlated with the ecological habits of the fish examined.
High-Order Semi-Discrete Central-Upwind Schemes for Multi-Dimensional Hamilton-Jacobi Equations
Bryson, Steve; Levy, Doron; Biegel, Bryan (Technical Monitor)
2002-01-01
We present the first fifth order, semi-discrete central upwind method for approximating solutions of multi-dimensional Hamilton-Jacobi equations. Unlike most of the commonly used high order upwind schemes, our scheme is formulated as a Godunov-type scheme. The scheme is based on the fluxes of Kurganov-Tadmor and Kurganov-Tadmor-Petrova, and is derived for an arbitrary number of space dimensions. A theorem establishing the monotonicity of these fluxes is provided. The spacial discretization is based on a weighted essentially non-oscillatory reconstruction of the derivative. The accuracy and stability properties of our scheme are demonstrated in a variety of examples. A comparison between our method and other fifth-order schemes for Hamilton-Jacobi equations shows that our method exhibits smaller errors without any increase in the complexity of the computations.
Hailati, G.; Hu, Z. H.
2016-08-01
The transient stability of interconnected network with supplementary time-delay controller for generator excitations and static var compensator (SVC) has been investigated in this paper. Firstly, a delay-dependent stability criterion based on Hamilton function method is derived, and the criterion is in term of matrix inequalities. Secondly, a nonlinear time-delay Hamilton function model of interconnected network with SVCs is constructed. Thirdly, the wide-area time-delay supplementary controller (WATSC) for the interconnected network is designed and converted into the form of Hamiltonian system. The delay-dependent stability of the closed-loop power system is analysed. The gains of the WATSC are determined by using the theoretical analysis results. It is effective for the designed WATSC installed in the 16- machine, 68-bus power system for damping the inter-area modes. Then simulation results show that the method of the controller is effective.
Self-gravitation interaction of IR deformed Hořava-Lifshitz gravity via new Hamilton-Jacobi method
Liu, Molin; Xu, Yin; Lu, Junwang; Yang, Yuling; Lu, Jianbo; Wu, Yabo
2014-06-01
The apparent discovery of logarithmic entropies has a significant impact on IR deformed Hořava-Lifshitz (IRDHL) gravity in which the original infrared (IR) property is improved by introducing three-geometry's Ricci scalar term "μ4 R" in action. Here, we reevaluate the Hawking radiation in IRDHL by using recent new Hamilton-Jacobi method (NHJM). In particular, a thorough analysis is considered both in asymptotically flat Kehagias-Sfetsos and asymptotically non-flat Park models in IRDHL. We find the NHJM offers simplifications on the technical side. The modification in the entropy expression is given by the physical interpretation of self-gravitation of the Hawking radiation in this new Hamilton-Jacobi (HJ) perspectives.
Performance Analysis of an Enhanced PRMA-HS Protocol for LEO Satellite Communication
ZHUO Yong-ning; YAN Shao-hu; WU Shi-qi
2005-01-01
The packet reservation multiple access with hindering state (PRMA-HS) is a protocol suitable for LEO satellite mobile communication. Although working well with light system payload (amount of user terminals), the protocol imposes high channel congestion on system with heavy payload, thus degrades the system's quality of service. To controlling the channel congestion, a scheme of enhanced PRMA-HS protocol is proposed, which aims to reduce the collision of voice packets by adopting a mechanism of access control. Through theoretic analysis, the system's mathematic model is presented and the packet drop probability of the scheme is deduced. To testify the performance of the scheme, a simulation is performed and the results support our analysis.
The e-NutriHS: a web-based system for a Brazilian cohort study.
Folchetti, Luciana D; da Silva, Isis T; de Almeida Pititto, Bianca; Ferreira, Sandra R G
2015-01-01
The e-NutriHS is a web-based system developed to gather online information on health of a cohort of college students and graduates in nutrition. It consists of six validated and internationally recognized questionnaires regarding demographic and socioeconomic data, dietary habits, physical activity level, alcohol and tobacco use, anti-fat attitudes and personal and family histories. Our software and respective database is hosted in the School of Public Health server and is based on free programming languages. An e-NutriHS prototype was created preceding online deployment. An improved version of the website was released based on 20 volunteers' opinions. A total of 503 users were registered. Considering that web-based systems produce reliable data, are easy to use, less costly and are less time-consuming, we conclude that our experience deserves to be shared, particularly with middle income economy countries.
Sulfur isotope effects associated with protonation of HS- and volatilization of H2S
Fry, B.; Gest, H.; Hayes, J. M.
1986-01-01
The isotope effects associated with: (1) formation of H2S from HS- by protonation in aqueous solution; and (2) volatilization of H2S have been experimentally determined. Both isotopic distributions in closed systems at equilibrium and differential rates of volatilization of isotopic species in open systems were measured at 22 +/- 1 degrees C. It was found that, at equilibrium aqueous H2S is enriched in 34S by 2.0 - 2.7% relative to HS- and that H2S volatilized from solution is depleted in 34S by 0.5% relative to dissolved H2S. A small kinetic isotope effect accompanying volatilization of H2S was observed in the open-system experiments.
Parkway公司和Hamilton sundstrand公司在墨西哥合资成立Parkway-HS公司
无
2009-01-01
Parkway制品公司（Parkway Products Inc．）和Hamilton sundstrand公司共同出资成立了一家名为Parkway-HSL．L．C．的新公司，专门生产低成本的航空航天产品。该公司的工厂位于墨西哥的萨尔提略市，占地面积超过2300m2。
2016-05-01
Algorithm for Overcoming the Curse of Dimensionality for Certain Non-convex Hamilton-Jacobi Equations, Projections and Differential Games Yat Tin...complexity of the resulting algorithm is polynomial in the problem dimension; hence, it overcomes the curse of dimensionality [1, 2]. We extend previous work...compute the evolution of geometric objects [25], which was first used for reachability problems in [21, 22] to our knowledge . Numerical solutions to HJ PDE
李仁杰; 乔永芬; 刘洋
2002-01-01
We present a general approach to the construction of conservation laws for variable mass nonholonomic noncon-servative systems. First, we give the definition of integrating factors, and we study in detail the necessary conditionsfor the existence of the conserved quantities. Then, we establish the conservation theorem and its inverse theorem forHamilton's canonical equations of motion of variable mass nonholonomic nonconservative dynamical systems. Finally,we give an example to illustrate the application of the results.
Sucrose Octaacetate Chemical Kinetics and Shelf Lives at Various Formulation pHs.
Gaddam, Shalini; Stagner, William C
2017-06-23
Developing pediatric friendly dosage forms is a high priority worldwide. Sucrose octaacetate (SOA) has been recommended for use as a surrogate for bitter tasting active pharmaceutical ingredients. Even though SOA has found a number of human use applications and has been employed for decades, there are no rigorous chemical kinetic studies reported. A recently reported SOA stability-indicating method was used to perform SOA chemical kinetic and stability studies. As part of the chemical kinetic study, reaction order, activation energies, extrapolated rate constants, pH-rate profiles at 4 and 25°C, and estimated shelf lives at 4 and 25°C at different buffer pHs are provided. The estimated SOA shelf lives at 25°C and pHs 4.00, 5.20, and 6.00 were 25.3, 114, and 27.4 days, respectively. At 4°C, SOA's estimated shelf lives were 0.478, 5.26, and 1.47 years at pHs 4.00, 5.20, and 6.00, respectively. SOA can be formulated at pHs 4 to 6 and stored at 25°C for short-duration (less than 25 days) uses such as a bitter tasting surrogate for fundamental taste mechanism studies or brief taste masking assessment clinical studies. For longer term solution studies, like being used as a bitter tasting control for blinded clinical trials, SOA should be formulated at the optimum pH of 5.40 and refrigerated at 4°C for maximum stability. The reported data can be used as a starting point for developing stable SOA formulations and estimating shelf life.
A New Compound Along With Seven Known Compounds from an Endophytic Fungus Aspergillus sp. HS-05
Gang Chen
2013-08-01
Full Text Available Investigation of EtOAc extract from the fermentation broth of the endophytic fungus Asperilligus sp. HS-05 led to the isolation of a new compound (1 of spiro moiety named aspergispiroketal and seven known compounds (2-8. Their structures were elucidated mainly by NMR and HR-TOF-MS, as well as on comparison with the reported data. The absolute configuration of 1 was defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra.
Linear and Nonlinear Optical Characterization of PolyDCHD-HS Films
CHEN Xianfeng; XIE Shengwu; CHEN Yingli; XIA Yuxin; S. Stefano; E. Giorgetti; G. Margatti
2000-01-01
Waveguiding films of the highly soluble polycarbazolydiacetylene polyDCHD-HS were prepared by spin coating and characterized at different wavelengths: 5 dB/cm propagation losses were observed at 1321 nm.Measurements of the third order nonliearity at 1064nm with the surface plasmon resonance method gave the valueχ(3)= i4.4×10-17+3.5×10-18 m2/V2.
Right-invariant Sobolev metrics ${H}^{s}$ on the diffeomorphisms group of the circle
Escher, Joachim
2012-01-01
We study the geodesic flow on the diffeomorphisms group of the circle with respect to the right-invariant metric induced by the fractional Sobolev norm $H^s$ for $s\\ge1/2$. We show that the corresponding initial value problem possesses a maximal solution in the smooth category and that the Riemannian exponential mapping is a smooth diffeomorphism from a neighbourhood of 0 in $C^{\\infty}(S)$ onto a neighbourhood of the identity in $Diff^{\\infty}(S)$.
Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000
Rune Brautaset; Ulrika Birkeldh; Petra Frehr Alstig; Petra Wikén; Maria Nilsson
2016-01-01
Background Optical coherence tomography (OCT), can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance. Methods Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS10...
Stephen A. Royle
2016-06-01
Full Text Available This article deals with the encounters between a traditional Korean rural and island population and western military forces when the British navy occupied Geomundo, an archipelago known to them as Port Hamilton, for 22 months between 1885 and 1887. The paper first outlines the sometimes painful process of East Asian countries being opened up to trade and outside influences in the 19th century, a process sometimes urged upon them by naval weapons in this era of gunboat diplomacy. This provides the setting for the Port Hamilton Affair itself when in preparation for possible war with Russia, a British naval squadron steamed into Port Hamilton and took it without reference to the local people or their national government. After brief reference to the political consequences of this action, the focus is then on what the records from the occupation and earlier investigations by the British, who had long coveted the islands’ strategic harbour, reveal about the life of the islanders. The article considers both their traditional life, from a time rather before western travel accounts were written about the Korean mainland, and how the islanders fared under the British.
郑利平
2012-01-01
Objective To investigate the changes of serum matrix metalloproteinase-9(MMP-9) and high sensitive Creactive protein(hs-CRP) expressions in the patients with chronic heart failure (CHF). Methods A total of 120 CHF patients was divided into 4 groups according to NYHA cardiac function classes of Ⅰ ,Ⅱ , Ⅲ and Ⅳ. The expression levels of MMP-9 and hs-CRP were detected with ELISA and Latex enhanced immunoturbidimetric assay, respectively, and compared among 4 NYHA cardiac cardiac function classes. Results The expression levels of MMP-9 and hs-CRP were increased as the cardiac function became worsen(P<0. 05). The expression of serum MMP-9 was positively correlated to that of hs-CRP(r=0. 716,P<0. 01). Conclusion When the cardiac dysfunction becomes severe in CHF patients,the expressions of MMP-9 and hs-CRP are remarkably increased, which may participate in the myocardial remodeling of CHF.%目的 探讨基质金属蛋白酶9(MMP-9)和高敏C反应蛋白(hs-CRP)在慢性心力衰竭(CHF)患者的表达.方法 CHF患者120例,ELISA检测血清MMP-9表达,乳胶增强免疫比浊法检测血清hs-CRP水平.比较不同NYHA心功能状态患者MMP-9和hs-CRP的表达差异.结果 随着心功能的恶化,MMP-9和hs-CRP的表达水平显著升高(P＜0.05).CHF患者外周血MMP-9和hs-CRP的表达水平呈正相关(r=0.716,P＜0.01).结论 CHF患者外周血MMP-9和hs-CRP表达水平随着心功能的减低而升高,MMP-9和hs-CRP表达可能参与了CHF心肌重构的病理过程.
Interference of anesthetics in blood alcohol analysis by HS-GC-FID: A case report.
Monteiro, C; Proença, P; Tavares, C; Castañera, A; Corte Real, F
2016-08-01
One of the techniques most widely used in ethanol analysis in forensic laboratories is undoubtedly the headspace gas chromatography with flame-ionization detection (HS-GC-FID) since the determination of this substance is carried out directly, without the need for additional purification procedures, which leads to increased productivity. This is a very important factor due to the high number of alcohol analysis requested to these laboratories. The presence of other volatile substances can cause a problem given the fact that they can be interferents in ethanol analysis by HS-GC-FID, which can have legal consequences related with driving under the influence of alcohol. The authors report a case of a routine analysis by HS-GC-FID for the determination of ethanol of a driver who has suffered an accident in which the use of two chromatographic columns with different polarities was essential to obtain an unequivocally identification of this substance in presence of an interfering volatile anesthetic administered in the hospital. The method was validated according to international recommendations before being introduced into routine laboratory in terms of selectivity, limits of detection (LOD), limits of quantification (LOQ), linearity, repeatability, intermediate precision, accuracy, robustness and carryover.
Infrared Studies of the Reflective Properties of Solar Cells and the HS376 Spacecraft
Frith, James; Reyes, Jacqueline; Cowardin, Heather; Anz-Meador, Phillip; Buckalew, Brent; Lederer, Susan
2016-01-01
In 2015, a selection of HS-376 buses were observed photometrically with the United Kingdom Infrared Telescope (UKIRT) to explore relationships between time-on-orbit and Near Infrared (NIR) color. These buses were chosen because of their relatively simple shape, for the abundance of similar observable targets, and their surface material being primarily covered by solar cells. While the HS-376 spacecraft were all very similar in design, differences in the specific solar cells used in the construction of each model proved to be an unconstrained variable that could affect the observed reflective properties. In 2016, samples of the solar cells used on various models of HS-376 spacecraft were obtained from Boeing and were analyzed in the Optical Measurements Center at the Johnson Space Center using a visible-near infrared field spectrometer. The laboratory-based spectra are convolved to match the photometric bands previously obtained using UKIRT and compared with the on-orbit photometry. The results and future work are discussed here.
Rosalia E Napitupulu
2013-08-01
Full Text Available BACKGROUND: Obesity is closely related to chronic, low grade systemic inflammation (metaflammation and it leads to further metabolic complications such as hypertension, atherosclerosis, and type 2 diabetes due to the adipocytokine imbalance. This study was carried out to assess the correlation between progranulin, granulin, adiponectin and visceral adipose tissue-derived serine protease inhibitor (Vaspin with metaflammation (high sensitivity C-reactive protein (hs-CRP in centrally obese men. METHODS: This study was observational with a cross sectional design involving 60 men aged 30-60 years, consisted of 43 obese men (waist circumference (WC ≥90 cm and 13 non obese men (WC 105 cm. CONCLUSIONS: We found metaflammation (hs-CRP was significantly correlated with Vaspin, but not with progranulin, granulin and adiponectin, in obese men. We suggest the possibility of a dynamic expression of adipokines related to WC that are subjected to adipocytes hypertrophy-hyperplasia phenomenon. KEYWORDS: progranulin, granulin, adiponectin, Vaspin, hs-CRP, metaflammation, central obesity.
Correlation of hs-CRP with environmental risk factors of nephropathy in type 2 diabetes
Jay Prakash Sah
2015-06-01
Full Text Available The objective of the present study was to investigate the association of hs-CRP levels with environmental risk factors of diabetic nephropathy like smoking, drinking alcohol, diet, age of diabetic patient, duration of diabetes, medication of diabetes, and blood pressure medication. A hospital-based quantitative study was conducted at the Department of Clinical Biochemistry of Manipal Teaching Hospital (MTH Pokhara, Nepal, with 89 patients suffering from type 2 diabetes. Blood samples (n=89 from the patients were collected and the serums were separated. On the other hand, data on environmental risk factors of nephropathy were collected by using standard questionnaire. In this study, serum hs-CRP level was not found to be correlated with smoking (p=0.111, alcohol consumption (p=0.722, diet (p=0.496, duration of diabetes (p=0.519, age of diabetic patient (p=0.369, medication of diabetes (p=0.734, and blood pressure medication (p=0.625. Hence, our study concludes that serum hs-CRP value in type 2 diabetic patients is insignificantly correlated with the risk factors especially smoking, drinking alcohol, diet, duration of diabetes, age of diabetic patient, medication of diabetes, and medication of blood pressure.
Shang, Da; Xie, Qionghong; Shang, Bin; Zhang, Min; You, Li; Hao, Chuan-Ming; Zhu, Tongying
2017-01-01
Background. Coronary artery calcification (CAC) contributes to high risk of cardiocerebrovascular diseases in dialysis patients. However, the risk factors for CAC initiation in peritoneal dialysis (PD) patients are not known clearly. Methods. Adult patients with baseline CaCS = 0 and who were followed up for at least 3 years or until the conversion from absent to any measurable CAC detected were included in this observational cohort study. Binary logistic regression was performed to identify the risk factors for CAC initiation in PD patients. Results. 70 patients recruited to our study were split into a noninitiation group (n = 37) and an initiation group (n = 33) according to the conversion of any measurable CAC during their follow-up or not. In univariate analysis, systolic blood pressure, serum phosphorus, fibrinogen, hs-CRP, serum creatinine, and triglycerides were positively associated with the initiation of CAC, while the high density lipoprotein and nPCR did the opposite function. Multivariate analysis revealed that hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation after adjustments. Conclusions. Hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation in PD patients. These results suggested potential clinical strategies to prevent the initiation of CAC in PD patients.
The relationship of urotensin II with insulin resistance and hs-CRP in patients having PCOS.
Yilmaz, Özgür; Calan, Ozlem; Kume, Tuncay; Calan, Mehmet
2013-11-01
UrotensinII (UII), one of the most potent vasoconstrictor proteins, may be associated with insulin resistance. The objective of our research was to determine the level of UII in sera of patients with PCOS and to investigate the relationship between UII and insulin resistance in patients with PCOS. Fourty seven PCOS patients and 42 healthy women were included in the study. Serum fasting glucose, insulin, UII, free testosterone and hs-CRP levels of the patients were examined. The HOMA-IR formula was used to calculate insulin resistance. Insulin sensitivity was calculated by using the QUICKI-IS formula. The two groups did not show any a significant difference in terms of age and BMI (p > 0.05). Serum UII, hs-CRP, insulin levels and the HOMA-IR were significantly higher in the patients with PCOS (p hs-CRP(r = 0.51, p < 0.001). Our study data suggested that UII may have a role in the pathophysiology of insulin resistance and increased cardiovascular risk, which are commonly found in patients with PCOS.
Rapid discrimination and feature extraction of three Chamaecyparis species by static-HS/GC-MS.
Chen, Ying-Ju; Lin, Chun-Ya; Cheng, Sen-Sung; Chang, Shang-Tzen
2015-01-28
This study aimed to develop a rapid and accurate analytical method for discriminating three Chamaecyparis species (C. formosensis, C. obtusa, and C. obtusa var. formosana) that could not be easily distinguished by volatile compounds. A total of 23 leaf samples from three species were analyzed by static-headspace (static-HS) coupled with gas chromatography-mass spectrometry (GC-MS). The static-HS procedure, whose experimental parameters were properly optimized, yielded a high Pearson correlation-based similarity between essential oil and VOC composition (r = 0.555-0.999). Thirty-six major constituents were identified; along with the results of cluster analysis (CA), a large variation in contents among the three different species was observed. Principal component analysis (PCA) methods illustrated graphically the relationships between characteristic components and tree species. It was clearly demonstrated that the static-HS-based procedure enhanced greatly the speed of precise analysis of chemical fingerprint in small sample amounts, thus providing a fast and reliable tool for the prediction of constituent characteristics in essential oil, and also offering good opportunities for studying the role of these feature compounds in chemotaxonomy or ecophysiology.
Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction.
Wang, Ke-Sheng; Wang, Liang; Liu, Xuefeng; Zeng, Min
2013-12-01
The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes.We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides). We examined genetic associations of 117 single-nucleotide polymorphisms (SNPs) within the HS6ST3 gene with obesity and triglycerides using two Caucasian samples: the Marshfield sample (1442 obesity cases and 2122 controls), and the Health aging and body composition (Health ABC) sample (305 cases and 1336 controls). Logistic regression analysis of obesity as a binary trait and linear regression analysis of triglycerides as a continuous trait, adjusted for age and sex, were performed using PLINK. Single marker analysis showed that six SNPs in the Marshfield sample and one SNP in the Health ABC sample were associated with obesity (P triglycerides in the Marshfield sample (P triglycerides in the Marshfield sample. These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology.
Exploring Dust Impacts on Tropical Systems from the NASA HS-3 Field Campaign
Nowottnick, Ed; Colarco, Pete; da Silva, Arlindo; Barahona, Donifan; Hlavka, Dennis
2015-01-01
One of the overall scientific goals of the NASA Hurricane and Severe Storm Sentinel (HS-3) field campaign is to better understand the role of the Saharan Air Layer (SAL) in tropical storm development. During the 2012 HS-3 deployment, the Cloud Physics Lidar (CPL) observed dust within SAL air in close proximity to a developing Nadine (September 11, 2012). Throughout the mission, the NASA GEOS-5 modeling system supported HS-3 by providing 0.25 degrees resolution 5-day global forecasts of aerosols, which were used to support mission planning. The aerosol module was radiatively interactive within the GEOS-5 model, but aerosols were not directly coupled to cloud and precipitation processes. In this study we revisit the aerosol forecasts with an updated version of the GEOS-5 model. For the duration of Hurricane Nadine, we run multiday climate simulations leading up to each respective Global Hawk flight with and without aerosol direct interaction. For each set of simulations, we compare simulated dust mass fluxes to identify differences in SAL entrainment related to the interaction between dust aerosols and the atmosphere. We find that the direct effects of dust induce a low level anticyclonic circulation that temporarily shields Nadine from the intrusion of dry air, leading to a more intense storm.
Inhibitory effects of HS014 on glutamate release in astrocytes chronically treated with morphine
Haichen Chu; Zejun Niu; Zhao Yang; Xuefeng Zhang
2010-01-01
Previous studies have confirmed that the number of glial fibrillary acidic protein-positive cells significantly increases during morphine tolerance.However,morphine tolerance is reversed with melanocortin receptor antagonists,and analgesic action is enhanced accordingly.However,these mechanisms remain unclear.In the present study,following addition of morphine to Wistar rat spinal cord astrocytes,glutamate levels in the supematant significantly increased(P<0.05).At 30-120minutes following addition of intervention agent to spinal cord astrocytes,naloxone significantly increased glutamate release in morphine-tolerant model cells(P < 0.05),while melanocortin receptor antagonist HS014 decreased glutamate release(P < 0.05).Additional naloxone and HS014 to astrocytes significantly decreased glutamate release compared with additional naloxone alone(P < 0.01).Results from the present study demonstrated that glutamate release was increased in spinal cord astrocytes co-cultured with morphine.Naloxone increased glutamate release,and HS014 reduced glutamate release.
Zhang, Xia; Huang, Wen-Juan; Yu, Zhi-Gang
2015-05-01
The objective of this study is to explore the relationship between the hypersensitive c-reactive protein (hs-CRP) level and the prognosis of acute brainstem infarction. Serum levels of hs-CRP were measured in 68 patients with acute brainstem infarction 72 h after disease onset. The hs-CRP levels in the U.S. National Institutes of Health Stroke Scale (NIHSS) score group and in the modified RANKIN scale (mRS) score group were compared. The independent risk factors of brainstem infarction were analyzed using Logistic binary regression. The hs-CRP level was significantly higher in the group with NIHSS >5 compared with the one with NIHSS ≤ 5 (P = 0.004). In the group with mRS > 2, the age, smoking history, and blood glucose level were significantly higher than those in the group with mRS ≤ 2 (P hs-CRP level was significantly higher (P = 0.001). Age and hs-CRP level were the independent prognostic factors of the brainstem infarction. The serum hs-CRP level is closely related with the severity and prognosis of brainstem infarction, and is an independent risk factor of acute brainstem infarction.
High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men
Lee, Jieun; Yoon, Kijung; Ryu, Seungho; Chang, Yoosoo; Kim, Hyoung-Ryoul
2017-01-01
We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138) of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (p< 0.001). As the hs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range) may require appropriate follow-up and management to prevent NAFLD development. PMID:28234943
The Chicken β-Globin 5′HS4 Boundary Element Blocks Enhancer-Mediated Suppression of Silencing
Walters, Mark C.; Fiering, Steven; Bouhassira, Eric E.; Scalzo, David; Goeke, Scott; Magis, Wendy; Garrick, David; Whitelaw, Emma; Martin, David I. K.
1999-01-01
A constitutive DNase I-hypersensitive site 5′ of the chicken β-globin locus, termed 5′HS4 or cHS4, has been shown to insulate a promoter from the effect of an upstream enhancer and to reduce position effects on mini-white expression in Drosophila cells; on the basis of these findings, it has been designated a chromatin insulator. We have examined the effect of the cHS4 insulator in a system that assays both the level of gene expression and the rate of transcriptional silencing. Because transgenes flanked by insulator elements are shielded from position effects in Drosophila cells, we tested the ability of cHS4 to protect transgenes from position effects in mammalian cells. Flanking of an expression vector with the cHS4 insulator in a colony assay did not increase the number of G418-resistant colonies. Using lox/cre-based recombinase-mediated cassette exchange to control integration position, we studied the effect of cHS4 on the silencing of an integrated β-geo reporter at three genomic sites in K562 erythroleukemia cells. In this assay, enhancers act to suppress silencing but do not increase expression levels. While cHS4 blocked enhancement at each integration site, the strength of the effect varied from site to site. Furthermore, at some sites, cHS4 inhibited the enhancer effect either when placed between the enhancer and the promoter or when placed upstream of the enhancer. These results suggest that the activity of cHS4 is not dominant in all contexts and is unlikely to prevent silencing at all genomic integration sites. PMID:10207095
The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing.
Walters, M C; Fiering, S; Bouhassira, E E; Scalzo, D; Goeke, S; Magis, W; Garrick, D; Whitelaw, E; Martin, D I
1999-05-01
A constitutive DNase I-hypersensitive site 5' of the chicken beta-globin locus, termed 5'HS4 or cHS4, has been shown to insulate a promoter from the effect of an upstream enhancer and to reduce position effects on mini-white expression in Drosophila cells; on the basis of these findings, it has been designated a chromatin insulator. We have examined the effect of the cHS4 insulator in a system that assays both the level of gene expression and the rate of transcriptional silencing. Because transgenes flanked by insulator elements are shielded from position effects in Drosophila cells, we tested the ability of cHS4 to protect transgenes from position effects in mammalian cells. Flanking of an expression vector with the cHS4 insulator in a colony assay did not increase the number of G418-resistant colonies. Using lox/cre-based recombinase-mediated cassette exchange to control integration position, we studied the effect of cHS4 on the silencing of an integrated beta-geo reporter at three genomic sites in K562 erythroleukemia cells. In this assay, enhancers act to suppress silencing but do not increase expression levels. While cHS4 blocked enhancement at each integration site, the strength of the effect varied from site to site. Furthermore, at some sites, cHS4 inhibited the enhancer effect either when placed between the enhancer and the promoter or when placed upstream of the enhancer. These results suggest that the activity of cHS4 is not dominant in all contexts and is unlikely to prevent silencing at all genomic integration sites.
Bender, M A; Roach, J N; Halow, J; Close, J; Alami, R; Bouhassira, E E; Groudine, M; Fiering, S N
2001-10-01
The mammalian beta-globin locus is a multigenic, developmentally regulated, tissue-specific locus from which gene expression is regulated by a distal regulatory region, the locus control region (LCR). The functional mechanism by which the beta-globin LCR stimulates transcription of the linked beta-like globin genes remains unknown. The LCR is composed of a series of 5 DNaseI hypersensitive sites (5'HSs) that form in the nucleus of erythroid precursors. These HSs are conserved among mammals, bind transcription factors that also bind to other parts of the locus, and compose the functional components of the LCR. To test the hypothesis that individual HSs have unique properties, homologous recombination was used to construct 5 lines of mice with individual deletions of each of the 5'HSs of the endogenous murine beta-globin LCR. Here it is reported that deletion of 5'HS1 reduces expression of the linked genes by up to 24%, while deletion of 5'HS4 leads to reductions of up to 27%. These deletions do not perturb the normal stage-specific expression of genes from this multigenic locus. In conjunction with previous studies of deletions of the other HSs and studies of deletion of the entire LCR, it is concluded that (1) none of the 5'HSs is essential for nearly normal expression; (2) none of the HSs is required for proper developmental expression; and (3) the HSs do not appear to synergize either structurally or functionally, but rather form independently and appear to contribute additively to the overall expression from the locus.
Potoglou, Dimitrios
The focus of this thesis is twofold. First, it offers insight on how households' car-ownership behaviour is affected by urban form and availability of local-transit at the place of residence, after controlling for socio-economic and demographic characteristics. Second, it addresses the importance of vehicle attributes, household and individual characteristics as well as economic incentives and urban form to potential demand for alternative fuelled vehicles. Data for the empirical analyses of the aforementioned research activities were obtained through an innovative Internet survey, which is also documented in this thesis, conducted in the Census Metropolitan Area of Hamilton. The survey included a retrospective questionnaire of households' number and type of vehicles and a stated choices experiment for assessing the potential demand for alternative fuelled vehicles. Established approaches and emerging trends in automobile demand modelling identified early on in this thesis suggest a disaggregate approach and specifically, the estimation of discrete choice models both for explaining car ownership and vehicle-type choice behaviour. It is shown that mixed and diverse land uses as well as short distances between home and work are likely to decrease the probability of households to own a large number of cars. Regarding the demand for alternative fuelled vehicles, while vehicle attributes are particularly important, incentives such as free parking and access to high occupancy vehicle lanes will not influence the choice of hybrids or alternative fuelled vehicles. An improved understating of households' behaviour regarding the number of cars as well as the factors and trade-offs for choosing cleaner vehicles can be used to inform policy designed to reduce car ownership levels and encourage adoption of cleaner vehicle technologies in urban areas. Finally, the Internet survey sets the ground for further research on implementation and evaluation of this data collection method.
Clinical utility of the Snaith-Hamilton-Pleasure scale in the Chinese settings
Liu Wen-hua
2012-10-01
Full Text Available Abstract Background The Snaith-Hamilton-Pleasure-Scale (SHAPS is a self-reported scale evaluating anhedonia for neuropsychiatric disorders. It has demonstrated with impressive psychometric properties and advantages in its applicability over other similar instruments. However, very few studies have been conducted to examine the clinical utility of the SHAPS in the context of Chinese settings. The current study aimed to examine the clinical utility of the translated version of the SHAPS in the Chinese clinical settings. Methods A Chinese version of SHAPS was administered to 336 college students to examine the internal consistency and test-retest reliability at a 4-week interval. Moreover, the translated SHAPS was also administered to 141 patients with major depression, 72 patients with schizophrenia, and 72 healthy controls to examine its clinical discrimination. Results The internal consistency of the SHAPS for the non-clinical sample and test-retest reliability at a 4- week interval were 0.85 and 0.64, respectively. Moreover, the SHAPS also showed an excellent internal consistency (alpha was 0.93 and a one-factor solution with the first factor accounted for 51.53% of the variance in the clinical psychiatric samples. ANOVA of the SHAPS total score indicated that the patients with depression scored significantly more anhedonia than the patients with schizophrenia and healthy controls (p Conclusions These findings suggest that the Chinese version of the SHAPS is a useful and promising instrument in assessing anhedonia for clinical patients and non-clinical individuals in the Chinese settings.
Poerschmann, J; Parsi, Z; Gorecki, T
2008-04-04
Analytical pyrolysis of sediments contaminated with pollutants of medium to high molecular weights (up to approximately 500 Da) is very challenging when using conventional pyrolysis systems due to discrimination of high molecular weight analytes. In the framework of this contribution, non-discriminating pyrolysis and thermochemolysis using rapid heating in a Silcosteel capillary were applied to study organic pollutants in heavily contaminated sediments taken from the Hamilton Harbor. The novel pyrolysis approach, requiring very small amounts of sample, turned out to be very useful as a rapid screening method, e.g. for risk assessment studies, proving superior to commonly used solvent extraction. Main pollutants in the sediments under study included aromatic hydrocarbons, chiefly originating from coal tar and petroleum. Polycyclic aromatic hydrocarbons (PAHs) beyond six-rings, including coronene and truxene, could be detected. Sequential tetramethyl ammonium hydroxide-induced thermochemolysis performed at 500 and 750 degrees C enabled the differentiation between organic pollutants sorbed onto the sediment matrix on the one hand, and structural moieties of the condensed polymeric humic sediment matrix along with bound residues on the other hand. Thermochemolysis at 500 degrees C removed sorbates quantitatively, leaving only bare polymeric humic matrix. Significant PAH source indicators provided evidence that the lipidic fraction sorbed onto the sediments originated from PAHs formed chiefly in coal combustion processes. The polymeric humic organic matter network of the less polluted sediment was mainly of petrogenic origin, whereas black carbon, kerogen, etc. contributed to the organic carbon of the heavily polluted sediment. Thermochemolysis at 500 degrees C was also used to study fatty acid profiles of the sediments. The fatty acid methyl ester patterns obtained for the two sites under study differed significantly, with strong indications that microbial attenuation
The Hamilton Rating Scale for Depression: A meta-analytic reliability generalization study
José A. López-Pina
2009-01-01
Full Text Available La generalización de la fiabilidad es una aproximación meta-analítica para estudiar cómo las estimaciones de la fiabilidad a partir de las puntuaciones de los tests dependen de las características específicas en las que el test se aplica y, en consecuencia, el riesgo de inducir la fiabilidad de las puntuaciones a partir de aplicaciones previas del test. La Escala de Evaluación de la Depresión de Hamilton (HAM-D, por su nombre en inglés es uno de los instrumentos de medida más populares de la psicología clínica para evaluar los síntomas depresivos y de la que se han construido algunas versiones. El presente estudio meta-analítico es un estudio de generalización de la fiabilidad (GF para probar la heterogeneidad de las estimaciones de la fiabilidad a través de los estudios, examinar la influencia de distintas características y compara los resultados con los obtenidos en estudios previos de GF en otras escalas de depresión. Los análisis llevados a cabo con 35 coeficientes alfa obtenidos a partir de 23 estudios publicados mostraron una fiabilidad media de 0,79 (DT = 0,14, elevada heterogeneidad a través de los estudios y que algunas características de los estudios influyeron en la fiabilidad de las puntuaciones, principalmente el número de ítems, la variabilidad de las puntuaciones y el tipo de trastorno estudiado en la muestra. Además, se discuten las implicaciones para investigadores y clínicos cuando se utiliza la escala HAM-D.
Sunita Jaiprakash Ramanand; Jaiprakash B Ramanand; Girish T. Raparti; Ravi R Ghanghas; Nimish R. Halasawadekar; Praveenkumar T. Patil; Mayur P. Pawar; Mayur P. Shinde
2014-01-01
Background: Role of hs-CRP was studied in PCOS women. Methods: Correlation between serum hs-CRP and endocrine, metabolic profile was studied in 30 healthy women and 88 PCOS women. In PCOS women correlation between hs-CRP and clinical characteristics viz obesity, infertility, acne, hirsutism, acanthosis nigricans (AN) was also studied. Serum levels of hs-CRP, Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH:FSH ratio, Testosterone (Testo), fasting insulin, fasting blood gluc...
贲其稳; 倪润洲; 肖明兵; 陆翠华; 李立人; 毛振彪
2008-01-01
目的:探讨肝癌特异性甲胎蛋白(HS-AFP)对肝细胞癌的诊断及鉴别诊断价值.方法:对105例肝癌患者及151例良性肝病血清HS-AFP及AFP进行检测,并对10例HS-AFP阳性的良性肝病患者进行15个月随访观察.HS-AFP采用不连续缓冲系统PAGE结合Western blot分离检测,AFP采用化学发光法测定.结果:105例肝癌患者HS-AFP和AFP＞200μg/L阳性率分别为60.0%和50.5%(P＞0.05),良性肝痛患者HS-AFP阳性率显著低于AFP＞200μg/L的阳性率(P＜0.05).AFP处于50-400μg/L范围的肝癌组HS-AFP阳性率为77.1%.良性肝病组阳性率为13.6%(P＜0.01).151例良性肝病中有10例HS-AFP出现阳性,其中3例于随访期间检出肝癌.11例小体积肝癌HS-AFP阳性率(45.5%)高于AFP＞200μg/L的阳性率(18.2%).结论:HS-AFP对肝癌的诊断价值优于AFP浓度.对肝癌高危人群监测HS-AFP有助于肝癌的早期诊断.对血清AFP中低浓度升高的良恶性肝病有较高的鉴别诊断价值.
李茂
2014-01-01
Objective:To explore the levels of NT-proBNP and hs-CRP in serum of patients with acute coronary syndrome. Methods:50 cases of ACS were as the observation group;40 cases of healthy persons were as the control group.We detected the changes in the levels of NT-proBNP and hs-CRP in serum of the two groups.Results:In the observation group,the levels of NT-proBNP and hs-CRP in serum were significantly increased.Compared with the control group,the difference was statistically significant(P<0.05).Conclusion:The detection of NT-proBNP and hs-CRP is of great significance in the diagnosis of acute coronary syndrome.%目的：观察急性冠脉综合征(ACS)患者血清中NT-proBNP和hs-CRP水平。方法：50例ACS患者作观察组，40例健康者作对照组，检测两组血清中NT-proBNP和hs-CRP水平的变化。结果：观察组血清中NT-proBNP与hs-CRP水平均显著升高，与对照组相比差异有统计学意义(P＜0.05)。结论：NT-proBNP和hs-CRP的检测对急性冠脉综合征的诊断具有重要意义。
Blyme, Adam; Asferg, Camilla; Nielsen, O. W.
2016-01-01
Objective To investigate relations between inflammation and aortic valve stenosis (AS) by measuring high-sensitivity C-reactive protein, at baseline (hsCRP(0)) and after 1year (hsCRP(1)) and exploring associations with aortic valve replacement (AVR). Design We examined 1423 patients from...... the Simvastatin and Ezetimibe in Aortic Stenosis study. Results During first year of treatment, hsCRP was reduced both in patients later receiving AVR (2.3 [0.9-4.9] to 1.8 [0.8-5.4] mg/l, p...) predicted later AVR (HR=1.17, paortic valve area (AVA) and other risk factors. A higher rate of AVR was observed in the group with high hsCRP(0) and an increase during the first year (AVR(highCRP0CRP1inc)=47.3% versus AVR(highCRP0CRP1dec)=27.5%, p
Bolić, Bojana; Mijušković, Ana; Popović-Bijelić, Ana; Nikolić-Kokić, Aleksandra; Spasić, Snežana; Blagojević, Duško; Spasić, Mihajlo B; Spasojević, Ivan
2015-12-01
Interactions of hydrogen sulfide (HS(-)/H2S), a reducing signaling species, with superoxide dimutases (SOD) are poorly understood. We applied low-T EPR spectroscopy to examine the effects of HS(-)/H2S and superoxide radical anion O2.- on metallocenters of FeSOD, MnSOD, and CuZnSOD. HS(-)/H2S did not affect FeSOD, whereas active centers of MnSOD and CuZnSOD were open to this agent. Cu(2+) was reduced to Cu(1+), while manganese appears to be released from MnSOD active center. Untreated and O2.- treated FeSOD and MnSOD predominantly show 5 d-electron systems, i.e. Fe(3+) and Mn(2+). Our study provides new details on the mechanisms of (patho)physiological effects of HS(-)/H2S.
Role of inflammation as reflected by serum hsCRP and ferritin level in major depressive disorder
Soma Gupta
2016-09-01
Conclusions: The significant change in hsCRP and Ferritin which is not associated with grade wise alteration suggests that probably inflammation is the early event which causes depression. Therefore no gradual change is observed with increase in severity of the disease. hsCRP can be used as a biomarker of Inflammation in MDD cases. [Int J Res Med Sci 2016; 4(9.000: 4072-4077
High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men.
Lee, Jieun; Yoon, Kijung; Ryu, Seungho; Chang, Yoosoo; Kim, Hyoung-Ryoul
2017-01-01
We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138) of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (phs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range) may require appropriate follow-up and management to prevent NAFLD development.
Yuttana Sudjaroen
2015-01-01
Full Text Available Context: Coronary atherosclerosis still presents one of the main causes of death. Efficacious prevention should focus on the early control of cardiovascular risk factors, including lipid profiles, which are unable early detect in subclinical cases. High-sensitive C-reactive protein (hs-CRP can prove to be an early cardiac risk predictor. Aims: 1 To compare hs-CRP levels between healthy volunteer with normal blood pressure and those with prehypertension, and 2 to use hs-CRP levels along with other risks to be a cardiac risk predictor. Setting and Design: This was a cross-sectional study for 6 months′ duration from January to June 2013 at Kudjab Hospital located in Udon Thani province, Thailand. Materials and Methods: Forty (40 healthy volunteers with prehypertension and 40 volunteers with normal blood pressure were included in the study. Both groups were similar in age range and sex. Twelve-hour (12-h fasting blood samples were collected from all the participants. Serum was assayed for hs-CRP and lipid profile. Results: All of parameters were statistically significant difference (P < 000.1. The hs-CRP level (6.27 ± 7.8 mg/L was elevated in the prehypertension group. The relative risk of hs-CRP for prehypertension was 6.3 with the odds ratio of 15.48, whereas the relative risk of lipid profiles for prehypertension prediction was only 1.28, with the odds ratio of 1.67. Statistical Analysis: SPSS version 11.0 using the unpaired t-test for comparing demographic data and blood parameters and risk prediction of hs-CRP and lipid profiles were calculated by relative risk with odds ratio [95% confidence interval (CI]. Conclusions: Hs-CRP is an early cardiac risk predictor even with normal lipid profile, and can help measure additional risk especially subclinical people such as prehypertension.
Bernardo, Maria S; Gonçalves, M; Lapa, N; Barbosa, R; Mendes, B; Pinto, F; Gulyurtlu, Ibrahim
2009-11-15
A method for the determination of 15 aromatic hydrocarbons in eluates from solid residues produced during the co-pyrolysis of plastics and pine biomass was developed. In a first step, several sampling techniques (headspace solid phase microextraction (HS-SPME), static headspace sampling (HS), and dispersive liquid-liquid microextraction (DLLME) were compared in order to evaluate their sensitivity towards these analytes. HS-SPME and HS sampling had the better performance, but DLLME was itself as a technique able to extract volatiles with a significant enrichment factor. HS sampling coupled with GC-MS was chosen for method validation for the analytes tested. Calibration curves were constructed for each analyte with correlation coefficients higher than 0.999. The limits of detection were in the range of 0.66-37.85 ng/L. The precision of the HS method was evaluated and good repeatability was achieved with relative standard deviations of 4.8-13.2%. The recoveries of the analytes were evaluated by analysing fortified real eluate samples and were in the range of 60.6-113.9%. The validated method was applied in real eluate samples. Benzene, toluene, ethylbenzene and xylenes (BTEX) were the compounds in higher concentrations. The DLLME technique coupled with GC-MS was used to investigate the presence of less volatile contaminants in eluate samples. This analysis revealed the presence of significant amounts of alkyl phenols and other aromatic compounds with appreciable water solubility.
Liu, Li-Bin; Li, Mu; Zhuo, Wen-Yan; Zhang, Yu-Sheng; Xu, An-Ding
2015-01-01
The aim of this study was to evaluate the diagnostic value of the serum biochemical markers high-sensitivity C-reactive protein (hs-CRP), D-dimer (DD) and fibrinogen (Fg) in differentiating etiological subtypes of ischemic stroke. This study was a retrospective case-only study, consecutively including patients with acute ischemic stroke. All patients were classified into subtypes using the TOAST classification system. A total of 317 patients were evaluated. Hs-CRP and DD levels were significantly different among the subtypes and were the highest in CE, followed by LAA and SAA; no significant difference between the subtypes was found for Fg. Hs-CRP > 6.96 mg/L was classified as the CE subtype, with a sensitivity of 41% and a specificity of 74%; DD > 791.30 ng/mL was classified as CE, with a sensitivity of 58% and a specificity of 78%. The combination of hs-CRP and DD classification as CE yielded a sensitivity of 65% and a specificity of 91%. DD > 791.30 ng/mL was considered an independent predictive factor of CE. Hs-CRP and DD could be useful for identifying the etiological subtypes of acute ischemic stroke, especially for predicting CE. The diagnostic value of DD was higher than that of hs-CRP.
Sanip, Zulkefli; Ariffin, Farah Diana; Al-Tahami, Belqes Abdullah Mohammed; Sulaiman, Wan Azman Wan; Rasool, Aida Hanum Ghulam
2013-01-01
Obese subjects had increased serum high sensitivity C-reactive protein (hs-CRP), decreased adiponectin levels, and impaired microvascular endothelial function compared to lean subjects. We investigated the relationships of serum hs-CRP, adiponectin and microvascular endothelial function with obesity indices and metabolic markers in overweight and obese female subjects. Anthropometric profile, body fat composition, biochemical analysis, serum hs-CRP and adiponectin levels, and microvascular endothelial function were measured in 91 female subjects. Microvascular endothelial function was determined using laser Doppler fluximetry and the process of iontophoresis. Mean age and body mass index (BMI) of subjects were 34.88 (7.87) years and 32.93 (4.82) kg/m(2). hs-CRP levels were positively correlated with weight, BMI, waist circumference, hip circumference, body fat and visceral fat. Adiponectin levels were positively correlated with insulin sensitivity index (HOMA-%S), and inversely correlated with waist hip ratio, triglyceride, fasting insulin and insulin resistance index (HOMA-IR). No relationship was seen between microvascular endothelial function and obesity indices, and metabolic markers. In overweight and obese female subjects, hs-CRP levels were correlated with obesity indices while adiponectin levels were inversely correlated with obesity indices and metabolic markers. No significant relationship was seen between microvascular endothelial function with obesity indices and metabolic markers including hs-CRP and adiponectin in female overweight and obese subjects.
Devanarayanan, Sivasankar; Nandeesha, Hanumanthappa; Kattimani, Shivanand; Sarkar, Siddharth; Jose, Jancy
2016-12-01
Inflammation, dyslipidemia and altered copper levels have been reported in several psychiatric disorders, including schizophrenia. However, their association with the severity of psychopathology in schizophrenia is yet to be established. The present study was designed to assess the serum levels of copper, highly sensitive C-reactive protein (hs-CRP) and lipid profile and to explore their association with psychopathology scores in schizophrenia. 40 cases and 40 controls were included in the study. Serum copper, hs-CRP and lipid profile were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS). Copper, hs-CRP, total cholesterol and LDL-Cholesterol were significantly increased and HDL-Cholesterol was significantly reduced in schizophrenia cases when compared with controls. Copper was positively correlated with hs-CRP (r=0.338, p=0.003). Total cholesterol was significantly correlated with PANSS total (r=0.452, p=0.003) and negative symptom scores (r=0.337, p=0.033). Triacylglycerol was positively correlated with general psychopathology symptom score (r=0.416, p=0.008). Copper and hs-CRP were increased and correlated well with each other in schizophrenia cases. Though total cholesterol and triacylglycerol showed positive association with severity of the psychopathology, copper and hs-CRP were not associated with the disease severity. Copyright © 2016 Elsevier B.V. All rights reserved.
Arthur Kummer
2010-08-01
Full Text Available Anxiety is common in Parkinson's disease (PD, but studies concerning specific anxiety disorders are scarce. Essential psychometric properties of anxiety rating scales are also lacking. OBJECTIVE: To investigate general anxiety disorder (GAD in PD and psychometric properties of the Hamilton Anxiety Rating Scale (Ham-A. METHOD: Ninety-one PD patients underwent neurological and psychiatric examination, which included the MINI-Plus, the Ham-A and the Hamilton Depression Rating Scale (Ham-D. RESULTS: GAD was present in 30.8% of PD patients. Patients with GAD had longer disease duration (p=0.044 and were in use of higher doses of levodopa (p=0.034. They also tended to have more motor fluctuations and dyskinesias. The group with GAD scored higher in Ham-A (pAnsiedade é comum na doença de Parkinson (DP, mas estudos sobre transtornos de ansiedade específicos são ainda escassos. Faltam também estudos sobre propriedades psicométricas essenciais das escalas de ansiedade. OBJETIVO: Investigar o transtorno de ansiedade generalizada (TAG na DP e propriedades psicométricas da Escala de Ansiedade de Hamilton (Ham-A. MÉTODO: Noventa e um pacientes com DP se submeteram a exames neurológico e psiquiátrico, que incluiu o MINI-Plus, a Ham-A e a Escala de Depressão de Hamilton (Ham-D. RESULTADOS: TAG esteve presente em 30,8% dos participantes. Pacientes com TAG tinham maior duração de doença (p=0,044 e estavam em uso de maiores doses de levodopa (p=0,034. Também havia uma tendência desses pacientes terem mais flutuações motoras e discinesias. O grupo com TAG pontuou mais alto na Ham-A (p<0,001, nas subescalas somática (p<0,001 e psíquica da Ham-A (p<0,001, e na Ham-D (p=0,004. A Ham-A mostrou boa consistência interna (alfa de Cronbach=0,893 e um ponto de corte de 10/11 é sugerido para triar o TAG. CONCLUSÃO: TAG é freqüente na DP e a Ham-A pode ser um instrumento útil para triar esse transtorno.
Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene × gender interaction
Ke-Sheng Wang; Liang Wang; Xuefeng Liu; Min Zeng
2013-12-01
The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes. We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides). We examined genetic associations of 117 single-nucleotide polymorphisms (SNPs) within the HS6ST3 gene with obesity and triglycerides using two Caucasian samples: the Marshfield sample (1442 obesity cases and 2122 controls), and the Health aging and body composition (Health ABC) sample (305 cases and 1336 controls). Logistic regression analysis of obesity as a binary trait and linear regression analysis of triglycerides as a continuous trait, adjusted for age and sex, were performed using PLINK. Single marker analysis showed that six SNPs in the Marshfield sample and one SNP in the Health ABC sample were associated with obesity $(P \\lt 0.05)$. SNP rs535812 revealed a stronger association with obesity in meta-analysis of these two samples $(P = 0.0105)$. The T–A haplotype from rs878950 and rs9525149 revealed significant association with obesity in the Marshfield sample $(P = 0.012)$. Moreover, nine SNPs showed associations with triglycerides in the Marshfield sample $(P \\lt 0.05)$ and the best signal was rs1927796 $(P = 0.00858)$. In addition, rs7331762 showed a strong gene × gender interaction $(P = 0.00956)$ for obesity while rs1927796 showed a strong gene × gender interaction $(P = 0.000625)$ for triglycerides in the Marshfield sample. These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology.
无
2010-01-01
佳能IXU S1000 HS具有10倍光学变焦．但机身厚度仅约22.3毫米．在秉承伊克萨斯系列时尚设计风格的同时．实现了高倍光学变焦．IXU S1000 HS共有3种机身色彩可供选择，包括玛瑙褐，宝石粉和珍珠银．不但配置了“HS SYSTEM”．
Tribological resistance of high speed steel HS 6-5-2 remelted with electric arc
A. Dziedzic
2009-07-01
Full Text Available The intensity of tribological wear of the high speed steel HS 6-5-2 remelted with the GTAW method has been compared to the heat treatment steel in a conventional way. Moreover, the types of the wear appeared during the friction. The tribiological research, were done in the technically dry friction conditions on a testing machine of the pin-on-disc T-01M. The smallest intensity of wear was shown by the high speed steel remelted with the parameters leading to obtain the biggest speed of cooling of the molten metal. The main wear type appearing during the research, was the abrasion and adhesive wear.
Material characteristics of CLEARCERAM-Z HS for use in large diameter mirror blanks
Kishi, Takayuki; Goto, Naoyuki; Hoffman, Brion; Kawashima, Yasuyuki; Suzuki, Kenji; Yoshizawa, Kazuharu; Suzuki, Kaito
2010-07-01
There is growing interest within the Astronomical community in the development and use of very large aperture telescopes which will incorporate the latest advancements in optical materials. Two of the most notable of these large size telescope projects, the Thirty Meter Telescope (TMT) and European Extremely Large Telescope (E-ELT), will use mirror segments in the actively controlled primary mirrors. In this paper we present the results of a material characteristics study on Ohara CLEARCERAM®-Z HS large diameter blanks which includes data on the CTE, CTE uniformity, residual stress and internal quality targeting potential use in the TMT Primary Mirror Segment Banks.
Study on the changes of RDW and hs-CRP in patients with preeclampsia%子痫前期患者 RDW 与 hs-CRP 检测的临床价值
王爱兰; 刘庆翠
2015-01-01
Objective:To evaluate the relationship of RDW and hs-CRP with the presence and severity of preeclampsia .Methods :RDW was meas-ured using blood cell counter ,and hs-CRP level of patients with preeclampsia was measured through ELISA method .Results:The RDW ,systolic and diastolic blood pressure ,proteinuria ,white blood cell and hs-CRP levels were significantly higher in preeclampsia group .Subgroup analysis revealed that RDW levels were significantly increased in patients with severe preeclampsia when compared to the patients with mild preeclampsia .Conclusion:The RDW and hs-CRP levels were significantly higher in preeclampsia group than control pregnancy patients ,and they increased with the increase of severity of disease ,the was a positive correlation between them .RDW can be used for indicator of severity of disease .%目的:评价红细胞分布宽度(RDW)及超敏C反应蛋白(hs -CRP)与子痫前期发病及严重程度的关系.方法:采用血细胞计数器测量 RDW值 ,酶联免疫吸附法(ELISA)测定子痫前期患者血清中CRP水平.结果:子痫前期组RDW、收缩压和舒张压、尿蛋白、白细胞和hs -CRP显著增高.亚组分析表明 ,重度子痫前期患者RDW水平较轻度组显著升高.结论:子痫前期患者RDW和hs-CRP明显高于正常妊娠者 ,且随着疾病严重程度的增加而升高 ,两者呈正相关.RDW可作为判断疾病轻重的指标.
Ângela Maria Alves e Souza; MARIA DE NAZARÉ DE OLIVEIRA FRAGA; LEILA MEMÓRIA PAIVA MORAES; MARIA LÚCIA PINHEIRO GARCIA; KARL DMITRI RAMOS MOURA; PAULO CÉSAR ALMEIDA
2008-01-01
La necesidad de evaluar la asistencia a un grupo de mujeres nos llevó a la aplicación de una escala. Fueron seleccionadas dieciocho usuarias con diagnóstico de trastornos neuróticos, relacionados al estrés y somato formes. Se aplicó la Escala de Evaluación de Ansiedad de Hamilton (HAM-A) con el objetivo de verificar el nivel de ansiedad antes y después de empezar las sesiones grupales. Realizamos 16 sesiones semanales, con desarrollo de técnicas de relajación y arte terapia, y como referencia...
Hossain, M Ilias
2013-01-01
Incorporating Parikh and Wilczek's opinion to the Kerr de-Sitter (KdS) black hole Hawking non-thermal and purely thermal radiations have been investigated using Hamilton-Jacobi method. We have taken the background spacetime of KdS black hole as dynamical, involving the self-gravitation effect of the emitted particles, energy and angular momentum has been taken as conserved and show that the tunneling rate is related to the change of Bekenstein-Hawking entropy and the derived emission spectrum deviates from the pure thermal spectrum. The explored results gives a correction to the Hawking radiation of KdS black hole.
WANG Peng-Zhou; ZHANG Hong-Hao; ZHANG Shun-Li; YAN Wen-Bin; LI Xue-Song
2008-01-01
By using combinatorics, we give a new proof for the recurrence relations of the characteristic polynomial coefficients, and we further obtain an explicit expression for the generic term of the coefficient sequence, which yields the trace formulae of the Cayley-Hamilton's theorem with all coefficients explicitly given. This implies a byproduct, a complete expression for the determinant of any finite-dimensional matrix in terms of the traces of its successive powers.And we discuss some of their applications to chiral perturbation theory and general relativity.
功能化CdS∶Mn荧光探针测定hs-DNA%Detection of hs-DNA by functinal CdS∶Mn fluorescent probe
张艺; 李紫薇; 何晓燕; 王兴磊
2015-01-01
在油胺溶剂中,利用溶剂热法于160℃加热反应12 h,合成了CdS∶Mn量子点,并用巯基乙酸对合成的量子点进行了包裹.借助X射线衍射分析、傅里叶红外光谱、荧光谱图等测试方法对材料进行表征,数据表明,合成的CdS∶Mn量子点JCPDS#为80-0019,在CdS∶Mn量子点上成功修饰上了羧基(-COOH),CdS∶Mn晶体修饰前后主要发射峰从526 nm蓝移至488 nm.以COOH-CdS∶Mn功能化材料为荧光探针,基于DNA对材料的荧光猝灭,实现了对DNA的定量测定.实验在pH=6.6条件下,功能化荧光材料的荧光强度和鲱鱼精DNA(hs-DNA)的质量浓度呈线性关系,线性方程为△F =78.69-0.179c,检出限为0.053 mg/L,相关系数R=0.998 8,RSD =0.27％.
Effects of fluorinated and hydrogenated surfactants on human serum albumin at different pHs.
Sabín, Juan; Prieto, Gerardo; González-Pérez, Alfredo; Ruso, Juan M; Sarmiento, Félix
2006-01-01
Complexation between human serum albumin (HSA) and two different surfactants, one fully fluorinated (sodium perfluorooctanoate, SPFO) and one fully hydrogenated (sodium caprylate, SO), was studied using zeta-potential measurements and difference spectroscopy. The study was carried out at three different pHs, 3.2, 6.7, and 10.0. The spectroscopy study was performed at pHs 6.7 and 10.0, given that at pH 3.2 high turbidity was observed in the wide range of surfactant concentrations. The results were interpreted in terms of the electrostatic and hydrophobic contributions to the stability of the different phases formed in the water-surfactant-HSA system. Solutions and precipitates were observed in the concentration range investigated in more detail. Using Pace methods, the thermodynamic values of the surfactant-induced conformational changes in HSA were determined for sodium perfluorooctanoate in the concentration range 2-12 mmol dm(-3) at pH 6.7 and 5-22 mmol dm(-3) at pH 10.0. Electrophoretic measurements were used to characterize surfactant adsorption by determining the number of molecules adsorbed on the surface of HSA and the Gibbs energy of adsorption. Finally, the interactions between human serum albumin and other anionic surfactants studied by other authors were compared with those observed in the present work.
Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000.
Rune Brautaset
Full Text Available Optical coherence tomography (OCT, can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance.Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. Repeatability was evaluated by use of the coefficient of repeatability (CR and the coefficient of repeatability as a percentage of the mean (CR%, and the obtained measurements were compared between the instruments.CR% of optic disc parameters ranged between 0.90 and 22.22% and 0.00 and 16.00% with the Canon and Zeiss OCT respectively. For macular parameters CR% ranged between 0.62 and 2.81% and 0.99 and 1.81% with the Canon and Zeiss OCT respectively. No statistical difference could be found when comparing the CR of all macular and disc measurements between the instruments. Compared to our previously published data repeatability has significantly improved with the inclusion of automatic tracking systems with both the Canon and Zeiss OCT.Automatic tracking function improves repeatability in both Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. However, measurements generated by the two instruments are still not interchangeable.
Marier, R; Andriole, V T
1978-07-01
We have compared continuous counterimmunoelectrophoresis (CCIE) and discontinuous counterimmunoelectrophoresis (DCIE) with immunodiffusion (ID) in the identification of Candida albicans antibody using HS antigen. Eighteen sera with a titer of 1/1 to 1/32 1/32 by CCIE were titered by CCIE and ID. Fewer were positive by CCIE and ID (13 of 18 and 9 of 18, respectively). Furthermore, the titers were lower when measured by these two methods in comparison to DCIE (4 of 18 and 3 of 18 sera had titers greather than or equal to 1/8 in comparison with 7 of 18 greater than or equal to 1/8 by DCIE). Finally, DCIE was found to be much faster than CCIE and ID. After 20 min of electrophoresis, 17 of 21 sera were positive by DCIE, whereas none were positive by CCIE. Even after 90 min, only 10 of 21 were positive by CCIE, whereas 4 of 21 were positive by ID. The increased sensitivity and speed of DCIE over CCIE and ID suggest that DCIE is preferable to these other methods in the measurement of candida antibody using HS antigen.
王挺; 连炬飞; 周永贤; 郭莉; 陈汉彪
2014-01-01
Objective To evaluate the clinical value of serum homocysteine (Hcy),cystalin C (CysC) and high-sensitivity C-reactive protein (hs-CRP) joint detect for the diagnosis of hypertensive disorders complicating pregnancy (HDP).Method Serum levels of Hcy,CysC and hs-CRP of 86 HDP patients (HDP group) and 96 normal pregnant women (control group) were measured,analyzed and compared.Results Comparing HDP group and control group,severe HDP group and mild HDP group,there were significances differences in serum levels of Hcy,CysC and hs-CRP(P＜0.05).Significant positive correlation exist between Hcy and Cysc,hs-CRP in HDP group (r=0.592,0.668),and the serum levels of Hcy,CysC and hs-CRP is positively correlated with the severity of HDP(r=0.759,0.266,0.365).Conclusion The serum levels of Hcy,CysC and hs-CRP in HDP patient is positively correlated with the severity of HDP.Joint detection of the serum levels of Hcy,CysC and hs-CRP is important for the diagnosis of HDP and illness progression and prognosis.%目的 探讨血清同型半胱氨酸(Hcy)、胱抑素C(CysC)及超敏-C反应蛋白(hs-CRP)联合检测对诊断妊娠期高血压疾病(HDP)的临床价值.方法 选取86例妊娠期高血压疾病患者(HDP组)和96例正常妊娠孕妇(对照组),分别检测血清Hcy 、CysC和hs-CRP,并对结果进行分析比较.结果 HDP组与对照组比较,重度HDP组与轻度HDP组比较,Hcy、CysC和hs-CRP差异均有统计学意义(P＜0.05).HDP组Hcy与CysC、hs-CRP呈显著正相关(r=0.592、0.668),且Hcy 、CysC和hs-CRP浓度与HDP病情轻重呈正相关(r=0.759、0.266、0.365).结论 HDP患者血清Hcy 、Cysc和hs-CRP浓度与HDP病情轻重呈正相关,联合检测对诊断妊娠期高血压疾病及其病情进展、预后判断具有重要的指导意义.
张丽娜; 车璐; 曹艳菲; 李新娜; 崔颖; 寇筱囡; 陈刚
2013-01-01
Objective We study if plasma levels of hs-CRP related to DM2+HBP patients. Methods hs-CRP were measured in subjects with DM2 and /or HBP, including 13 patients with DM2, 17 patients with HBP, 34 patients with DM2+HBP, and 25 healthy test control subjects. hs-CRP tested by Electro-Chemiluminescence Immuno Assay (ECLI). Results The plasma hs-CRP levels were significantly lower in the controls than in the DM2+HBP group (p<0.05), DM2 associated with HBP was also correlated with increased plasma hs-CRP levels (n=89, r =0.25, p=0.0160). Conclusions This study suggests that patients with two associated diseases have a more active inflammatory state.%目的：研究炎性反应标志物超敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）与2型糖尿病(type 2 diabetes mel itus, DM2)伴随或者不伴随高血压是否存在相关性。方法入组13例2型糖尿病患者无合并症，17例高血压患者(high blood pressure, HBP)，34例2型糖尿病伴随高血压患者（DM2+HBP），25例健康体检对照组，电化学免疫发光法测定血清hs-CRP。结果健康对照组hs-CRP水平明显低于HBP+DM2患者（p＜0.05），DM2伴随HBP与hs-CRP水平显著相关（n=89， r=0.25， p=0.0160）。讨论 DM2+HBP患者具有相对活跃的炎性状态。
Seggelen Vera
2005-02-01
Full Text Available Abstract Background In human carcinomas, overexpression of cortactin correlates with poor prognosis. Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp2/3 mediated actin polymerization. It shares a high amino acid sequence and structural similarity to hematopoietic lineage cell-specific protein 1 (HS1 although their functions differ considerable. In this manuscript we describe the genomic organization of these two genes in a variety of species by a combination of cloning and database searches. Based on our analysis, we predict the genesis of the actin-binding repeat domain during evolution. Results Cortactin homologues exist in sponges, worms, shrimps, insects, urochordates, fishes, amphibians, birds and mammalians, whereas HS1 exists in vertebrates only, suggesting that both genes have been derived from an ancestor cortactin gene by duplication. In agreement with this, comparative genome analysis revealed very similar exon-intron structures and sequence homologies, especially over the regions that encode the characteristic highly conserved F-actin-binding repeat domain. Cortactin splice variants affecting this F-actin-binding domain were identified not only in mammalians, but also in amphibians, fishes and birds. In mammalians, cortactin is ubiquitously expressed except in hematopoietic cells, whereas HS1 is mainly expressed in hematopoietic cells. In accordance with their distinct tissue specificity, the putative promoter region of cortactin is different from HS1. Conclusions Comparative analysis of the genomic organization and amino acid sequences of cortactin and HS1 provides inside into their origin and evolution. Our analysis shows that both genes originated from a gene duplication event and subsequently HS1 lost two repeats, whereas cortactin gained one repeat. Our analysis genetically underscores the significance of the F-actin binding domain in
张翠玲; 姜艳梅; 高霞; 王欣
2008-01-01
[目的]通过对h-FABP、hs-CRP、cTnT 3项指标的联合检测为急性心肌梗死(AMI)的诊断提供可靠依据.[方法]cTnT检测采用金标记免疫渗滤法;hs-CRP检测采用免疫散射比浊法;h-FABP检测采用96T ELISA方法.[结果]健康组与AMI组比较,h-FABP:(5.46±0.19),(23.27±1.77)ng/mL,P＜0.01;cTnT:(0.10±0.01),(0.64±0.11)ng/mL,P＜0.01;hs-CRP:(0.85±0.10),(17.39±4.69)mg/L,P＜0.01;cTnT、hs-CRP、h-FABP在40例AMI患者发作0～3 h阳性率分别为50%、55.26%、85%.3项指标联合分析阳性率可达98%.[结论]h-FABP、hs-CRP与cTnT联合检测对AMI早期诊断具有高灵敏性和特异性.
Salisbury, Donald; Renn, Jürgen; Sundermeyer, Kurt
2016-02-01
Classical background independence is reflected in Lagrangian general relativity through covariance under the full diffeomorphism group. We show how this independence can be maintained in a Hamilton-Jacobi approach that does not accord special privilege to any geometric structure. Intrinsic space-time curvature-based coordinates grant equal status to all geometric backgrounds. They play an essential role as a starting point for inequivalent semiclassical quantizations. The scheme calls into question Wheeler’s geometrodynamical approach and the associated Wheeler-DeWitt equation in which 3-metrics are featured geometrical objects. The formalism deals with variables that are manifestly invariant under the full diffeomorphism group. Yet, perhaps paradoxically, the liberty in selecting intrinsic coordinates is precisely as broad as is the original diffeomorphism freedom. We show how various ideas from the past five decades concerning the true degrees of freedom of general relativity can be interpreted in light of this new constrained Hamiltonian description. In particular, we show how the Kuchař multi-fingered time approach can be understood as a means of introducing full four-dimensional diffeomorphism invariants. Every choice of new phase space variables yields new Einstein-Hamilton-Jacobi constraining relations, and corresponding intrinsic Schrödinger equations. We show how to implement this freedom by canonical transformation of the intrinsic Hamiltonian. We also reinterpret and rectify significant work by Dittrich on the construction of “Dirac observables.”
Jyh-Chang Hwang
Full Text Available A high sensitivity C-reactive protein to albumin ratio (hs-CRP/Alb predicts mortality risk in patients with acute kidney injury. However, it varies dynamically. This study was conducted to evaluate whether a variation of this marker was associated with long-term outcome in clinically stable hemodialysis (HD patients.hs-CRP/Alb was checked bimonthly in 284 clinically stable HD outpatients throughout all of 2008. Based on the "slope" of trend equation derived from 5-6 hs-CRP/alb ratios for each patient, the total number of patients was divided into quartiles--Group 1: β≦ -0.13, n = 71; group 2: β>-0.13≦0.003; n = 71, group 3: β>0.003≦0.20; and group 4: β>0.20, n = 71. The observation period was from January 1, 2009 to August 31, 2012.Group 1+4 showed a worse long-term survival (p = 0.04 and a longer 5-year hospitalization stay than Group 2+3 (38.7±44.4 vs. 16.7±22.4 days, p<0.001. Group 1+4 were associated with older age (OR = 1.03, 95% CI = 1.01-1.05 and a high prevalence of congestive heart failure (OR = 2.02, 95% CI = 1.00-4.11. Standard deviation (SD of hs-CRP/Alb was associated with male sex (β = 0.17, p = 0.003, higher Davies co-morbidity score (β = 0.16, p = 0.03, and baseline hs-CRP (β = 0.39, p<0.001. Patients with lower baseline and stable trend of hs-CRP/Alb had a better prognosis. By multivariate Cox proportional methods, SD of hs-CRP/alb (HR: 1.05, 95% CI: 1.01-1.08 rather than baseline hs-CRP/Alb was an independent predictive factor for long-term mortality after adjusting for sex and HD vintage.Clinically stable HD patients with a fluctuating variation of hs-CRP/Alb are characterized by old age, and more co-morbidity, and they tend to have longer subsequent hospitalization stay and higher mortality risk.
Dexi Bi
Full Text Available Plasmids play critical roles in bacterial fitness and evolution of Pseudomonas aeruginosa. Here two plasmids found in a drug-resistant P. aeruginosa clinical isolate HS87 were completely sequenced. The pHS87b plasmid (11.2 kb carries phage-related genes and function-unknown genes. Notably, pHS87b encodes an integrase and has an adjacent tRNAThr-associated attachment site. A corresponding integrated form of pHS87b at the tRNAThr locus was identified on the chromosome of P. aeruginosa, showing that pHS87b is able to site-specifically integrate into the 3'-end of the tRNAThr gene. The pHS87a plasmid (26.8 kb displays a plastic structure containing a putative replication module, stability factors and a variable region. The RepA of pHS87a shows significant similarity to the replication proteins of pPT23A-family plasmids. pHS87a carries a transposon Tn6049, a truncated insertion sequence ΔIS1071 and a Tn402-like class 1 integron which contains an aacA4 cassette that may confer aminoglycoside resistance. Thus, pHS87b is a site-specific integrative plasmid whereas pHS87a is a plastic antibiotic resistance plasmid. The two native plasmids may promote the fitness and evolution of P. aeruginosa.
Yaodong Dong
Full Text Available Aminoglycoside antibiotics such as gentamicin could cause ototoxicity in mammalians, by inducing oxidative stress and apoptosis in sensory hair cells of the cochlea. Sodium hydrosulfide (NaHS is reported to alleviate oxidative stress and apoptosis, but its role in protecting aminoglycoside-induced hearing loss is unclear. In this study, we investigated the anti-oxidant and anti-apoptosis effect of NaHS in in vitro cultured House Ear Institute-Organ of Corti 1 (HEI-OC1 cells and isolated mouse cochlea. Results from cultured HEI-OC1 cells and cochlea consistently indicated that NaHS exhibited protective effects from gentamicin-induced ototoxicity, evident by maintained cell viability, hair cell number and cochlear morphology, reduced reactive oxygen species production and mitochondrial depolarization, as well as apoptosis activation of the intrinsic pathway. Moreover, in the isolated cochlear culture, NaHS was also demonstrated to protect the explant from gentamicin-induced mechanotransduction loss. Our study using multiple in vitro models revealed for the first time, the potential of NaHS as a therapeutic agent in protecting against aminoglycoside-induced hearing loss.
Dong, Yaodong; Liu, Dongliang; Hu, Yue; Ma, Xiulan
2015-01-01
Aminoglycoside antibiotics such as gentamicin could cause ototoxicity in mammalians, by inducing oxidative stress and apoptosis in sensory hair cells of the cochlea. Sodium hydrosulfide (NaHS) is reported to alleviate oxidative stress and apoptosis, but its role in protecting aminoglycoside-induced hearing loss is unclear. In this study, we investigated the anti-oxidant and anti-apoptosis effect of NaHS in in vitro cultured House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and isolated mouse cochlea. Results from cultured HEI-OC1 cells and cochlea consistently indicated that NaHS exhibited protective effects from gentamicin-induced ototoxicity, evident by maintained cell viability, hair cell number and cochlear morphology, reduced reactive oxygen species production and mitochondrial depolarization, as well as apoptosis activation of the intrinsic pathway. Moreover, in the isolated cochlear culture, NaHS was also demonstrated to protect the explant from gentamicin-induced mechanotransduction loss. Our study using multiple in vitro models revealed for the first time, the potential of NaHS as a therapeutic agent in protecting against aminoglycoside-induced hearing loss. PMID:26295804
Jian-Lin Huang
2013-07-01
Full Text Available We decorated HS-functionalized cellulose nanocrystallite (CNC films with monodisperse Au nanoparticles (AuNPs to form a novel nanocomposite catalyst AuNPs@HS-CNC. The uniform, fine AuNPs were made by the reduction of HAuCl4 solution with thiol (HS- group-functionalized CNC films. The AuNPs@HS-CNC nanocomposites were examined by X-ray photoelectron spectroscopy (XPS, TEM, ATR-IR and solid-state NMR. Characterizations suggested that the size of the AuNPs was about 2–3 nm and they were evenly distributed onto the surface of CNC films. Furthermore, the unique nanocomposite Au@HS-CNC catalyst displayed high catalytic efficiency in promoting three-component coupling of an aldehyde, an alkyne, and an amine (A3-coupling either in water or without solvent. Most importantly, the catalyst could be used repetitively more than 11 times without significant deactivation. Our strategy also promotes the use of naturally renewable cellulose to prepare reusable nanocomposite catalysts for organic synthesis.
Zhu, Rui; Wu, Min; Yang, Jian
2013-01-01
Sludge retention time (SRT) and phosphorus to carbon ratio (P/C) in the feed are important control parameters in biological phosphorus removal. In this study, humus soil sequencing batch reactor (HS-SBR) process was operated with different SRTs (five, 10 and 15 days) and P/C feeding (0.0125 and 0.1) to evaluate their phosphorus removal efficiencies. The HS-SBR was composed of a humus soil reactor (HSR) and a conventional SBR (designated as hsSBR to differentiate from the conventional SBR used as a control). The results showed that the phosphorus removal efficiency was 82.7%, 97.3% and 97.3% at SRTs of five, 10 and 15 days respectively and acetate utilization efficiency for phosphorus release with SRTs of 10 and 15 days was much higher than that with an SRT of five days. In addition, a high P/C feeding (0.1) could promote the growth of the phosphate accumulating organisms in the hsSBR; however, the efficiency of phosphorus removal was lower than a low P/C feeding (0.0125) at an SRT of 15 days. All these observations suggested that a relatively long SRT and low P/C feeding exert a useful effect on the phosphorus removal in the hsSBR.
Rasmidar Samad
2015-06-01
Full Text Available C-Reactive Protein and serum lipids are correlated with atherosclerosis. The purpose of this study was to prove that increasing level of hs-CRP and serum lipids were correlated with periodontitis. This was a cross-sectional approach with 63 samples. Periodontitis was determined if the pocket depth (PD was more than 4 mm and the attachment loss (AL was more than 2 mm. Serum lipids and hs-CRP was analyzed by enzymatic method and chemiluminescent (Immulite hs_CRP alternatively. With unpaired t-test it has showed that there was a difference level of hs-CRP and total cholesterol in periodontitis and non-periodontitis. It was found that there was a significant positive correlation between PD (r=0.26, AL (r=0.25 with hs-CRP serum level; and PD (r=0.27, AL (r=0.30 with total cholesterol and LDL. It was concluded that there is a possibility that there is a relationship between periodontitis and atherosclerosis.
Yu, Qian; Wang, Binrong; Zhao, Tianzhi; Zhang, Xiangnan; Tao, Lei; Shi, Jinshan; Sun, Xude; Ding, Qian
2017-01-01
Brain ischemia leads to poor oxygen supply, and is one of the leading causes of brain damage and/or death. Neuroprotective agents are thus in great need for treatment purpose. Using both young and aged primary cultured hippocampal neurons as in vitro models, we investigated the effect of sodium hydrosulfide (NaHS), an exogenous donor of hydrogen sulfide, on oxygen-glucose deprivation (OGD) damaged neurons that mimick focal cerebral ischemia/reperfusion (I/R) induced brain injury. NaHS treatment (250 μM) protected both young and aged hippocampal neurons, as indicated by restoring number of primary dendrites by 43.9 and 68.7%, number of dendritic end tips by 59.8 and 101.1%, neurite length by 36.8 and 66.7%, and spine density by 38.0 and 58.5% in the OGD-damaged young and aged neurons, respectively. NaHS treatment inhibited growth-associated protein 43 downregulation, oxidative stress in both young and aged hippocampal neurons following OGD damage. Further studies revealed that NaHS treatment could restore ERK1/2 activation, which was inhibited by OGD-induced protein phosphatase 2 (PP2A) upregulation. Our results demonstrated that NaHS has potent protective effects against neuron injury induced by OGD in both young and aged hippocampal neurons.
Huang, Jian-Lin
2013-01-01
Summary We decorated HS-functionalized cellulose nanocrystallite (CNC) films with monodisperse Au nanoparticles (AuNPs) to form a novel nanocomposite catalyst AuNPs@HS-CNC. The uniform, fine AuNPs were made by the reduction of HAuCl4 solution with thiol (HS-) group-functionalized CNC films. The AuNPs@HS-CNC nanocomposites were examined by X-ray photoelectron spectroscopy (XPS), TEM, ATR-IR and solid-state NMR. Characterizations suggested that the size of the AuNPs was about 2–3 nm and they were evenly distributed onto the surface of CNC films. Furthermore, the unique nanocomposite Au@HS-CNC catalyst displayed high catalytic efficiency in promoting three-component coupling of an aldehyde, an alkyne, and an amine (A3-coupling) either in water or without solvent. Most importantly, the catalyst could be used repetitively more than 11 times without significant deactivation. Our strategy also promotes the use of naturally renewable cellulose to prepare reusable nanocomposite catalysts for organic synthesis. PMID:23946833
蔡念光; 王玉凤; 王晓明; 程健君; 贾天军; 吕占军
2011-01-01
Objective To analyze the correlation between coronary heart disease(CHD) and the gene polymorphism of mannan binding lectin(MBL), the plasma contents of MBL and the level of high-sensitivity C-reactive protein (hs-CRP).Methods The anti-coagulated blood of CHD patients (group CHD, 100 cases) and healthy people(group C,60 cases) was collected.The point mutation of MBL ExonI 54 codon was detected by PCR-RFLP.The content of MBL and the level of hs-CRP were detected by ELISA kit and immunoturbidimetry, respectively.Results There was no significant difference in the genotypes of MBL ExonI 54 codon between group CHD and group C(P＞0.05).The plasma content of MBL and the level of hs-CRP in group CHD were higher than those in group C (P＜0.01).In group CHD, there was no obvious difference in the content of MBL between the patients with high level of hs-CRP(＞3 mg/L) and those with normal level of hs-CRP(＜3 mg/L) (P＞0.05).Conclusion MBL and hs-CRP may be involved in the occurrence and development of CHD via different mechanisms.%目的 研究冠心病(CHD)与甘露聚糖结合凝集素(MBL)基因多态性及其血浆MBL和高敏G-反应蛋白(hs-CRP)水平的关系.方法 收集100例CHD患者(CHD组)和60例健康人群(对照组)抗凝血,限制片段长度多态性法(PCR-RFLP)检测MBL ExonI 54位密码子基因点突变,ELISA法和免疫比浊法分别检测血浆MBL含量和高敏G-反应蛋白(hs-CRP)水平.结果 CHD组与对照组MBL基因ExonI 54位密码子点突变频率比较差异无统计学意义(P＞0.05).CHD组血浆MBI和hs-CRP含量均高于对照组(P＜0.01).而CHI组内血浆hs-CRP水平升高者(＞3 mg/L)与hs-CRP水平正常者(＜3 mg/L)MBL含量比较差异无统计学意义(P＞0.05).结论 MBL和hs-CRP可能以不同机制参与CHD发生、发展过程.
RoHS directive: restriction of the use of lead in electronic equipment
2007-01-01
The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here. Please note that the session will be held in French.
RoHS directive: restriction of the use of lead in electronic equipment
2007-01-01
The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 to p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here Please note that the session will be held in French.
Pizzol, Massimo; Thomsen, Marianne
Waste from Electrical and Electronic Equipment (WEEE) is the fastest growing waste fraction in Europe and is classified as hazardous as it may include substances that have adverse effects on human health or cause damage to the environment (UNEP, 2009). The European Community Directive 2002/96/EC...... on Waste Electrical and Electronic Equipment (WEEE Directive), together with the European Community Directive 2002/95/EC on the Restriction of Hazardous Substances (RoHS Directive) were established respectively to set collection, recycling and recovery targets, and to restrict the use of six hazardous......HS directive, flows of toxic compounds are still significant in WEEE, as can be demonstrated by performing a Substance Flow Analysis (SFA) (Brunner, 2004) on a Danish WEEE treatment facility. This is due to the presence, in the WEEE, of devices constituting an exception to the RoHS directive and of other...
RoHS regulated substances in mixed plastics from waste electrical and electronic equipment.
Wäger, Patrick A; Schluep, Mathias; Müller, Esther; Gloor, Rolf
2012-01-17
The disposal and recovery of plastics from waste electrical and electronic equipment (WEEE) are of considerable importance, both from an environmental and an economic perspective. This paper presents the results of a study investigating current concentrations of hazardous substances in mixed plastics from WEEE and their implications for an environmentally sound recovery. The study included 53 sampling campaigns for mixed plastics from WEEE. The samples were analyzed with regard to heavy metals (cadmium, chromium, mercury, and lead) and flame retardants (PentaBDE, OctaBDE, DecaBDE, DecaBB) regulated in the RoHS Directive. Besides these substances, other brominated flame retardants known to occur in electronics (HBCD, TBBPA) as well as the total bromine and phosphorus contents were considered. Results show that no mixed plastics fraction from WEEE is completely free from substances regulated in the RoHS Directive. The lowest number and average concentrations were found in flat screen monitors. The highest concentrations were found in mixed plastics from CRT monitors and TVs. Mixed plastics fractions with high average concentrations of heavy metals originate from the treatment of small household appliances (cadmium), ICT equipment (lead), and consumer equipment (lead). Mixed plastics fractions with high average concentrations of brominated flame retardants mainly originate from the treatment of small household appliances for high temperature applications (DecaBDE), CRT monitors (OctaBDE and DecaBDE) and consumer equipment (DecaBDE), in particular CRT TVs (DecaBDE). To avoid a dissipation of hazardous substances into plastics and the environment, it is recommended that mixed plastics from WEEE are subject to a strict quality management.
Nattich-Rak, Małgorzata; Adamczyk, Zbigniew; Wasilewska, Monika; Sadowska, Marta
2015-07-01
Adsorption mechanism of human fibrinogen on mica at different pHs is studied using the streaming potential and colloid deposition measurements. The fibrinogen monolayers are produced by a controlled adsorption under diffusion transport at pH of 3.5 and 7.4. Initially, the electrokinetic properties of these monolayers and their stability for various ionic strength are determined. It is shown that at pH 3.5 fibrinogen adsorbs irreversibly on mica for ionic strength range of 4×10(-4) to 0.15 M. At pH 7.4, a partial desorption is observed for ionic strength below 10(-2) M. This is attributed to the desorption of the end-on oriented molecules whereas the side-on adsorbed molecules remain irreversibly bound at all ionic strengths. The orientation of molecules and monolayer structure is evaluated by the colloid deposition measurements involving negatively charged polystyrene latex microspheres, 820 nm in diameter. An anomalous deposition of negative latex particles on substrates exhibiting a negative zeta potential is observed. At pH 3.5 measurable deposition of latex is observed even at low ionic strength where the approach distance of latex particles exceeded 70 nm. At pH 7.4 this critical distance is 23 nm. This confirms that fibrinogen monolayers formed at both pHs are characterized by the presence of the side-on and end-on oriented molecules that prevail at higher coverage range. It is also shown that positive charge is located at the end parts of the αA chains of the adsorbed fibrinogen molecules. Therefore, it is concluded that the colloid deposition method is an efficient tool for revealing protein adsorption mechanisms at solid/electrolyte interfaces.
2014-01-01
Past research in Hamilton, Ontario has found that age and longevity of residence are positively associated with evaluations of sense of place (SoP); further, evaluations of SoP between immigrants and Canadian-born individuals have shown no clear pattern (Williams et al. 2010; Williams and Kitchen 2012). This paper builds on this work by further examining evaluations of SoP among both immigrants and Canadian-born residents and across gender in Hamilton, while expanding the study to two other s...
Guerrieri, Elena; Mallareddy, Jayapal Reddy; Tóth, Géza; Schmidhammer, Helmut; Spetea, Mariana
2015-03-18
Herein we report the radiolabeling and pharmacological investigation of a novel radioligand, the N-cyclobutylmethyl substituted diphenethylamine [(3)H]HS665, designed to bind selectively to the kappa opioid peptide (KOP) receptor, a target of therapeutic interest for the treatment of a variety of human disorders (i.e., pain, affective disorders, drug addiction, and psychotic disorders). HS665 was prepared in tritium-labeled form by a dehalotritiated method resulting in a specific activity of 30.65 Ci/mmol. Radioligand binding studies were performed to establish binding properties of [(3)H]HS665 to the recombinant human KOP receptor in membranes from Chinese hamster ovary cells stably expressing human KOP receptors (CHOhKOP) and to the native neuronal KOP receptor in guinea pig brain membranes. Binding of [(3)H]HS665 was specific and saturable in both tissue preparations. A single population of high affinity binding sites was labeled by [(3)H]HS665 in membranes from CHOhKOP cells and guinea pig brain with similar equilibrium dissociation constants, Kd, 0.45 and 0.64 nM, respectively. Average receptor density of [(3)H]HS665 recognition sites were 5564 and 154 fmol/mg protein in CHOhKOP cells and guinea pig brain, respectively. This study shows that the new radioligand distinguishes and labels KOP receptors specifically in neuronal and cellular systems expressing KOP receptors, making this molecule a valuable tool in probing structural and functional mechanisms governing ligand-KOP receptor interactions in both a recombinant and native in vitro setting.
Nynne Sharma
Full Text Available DNA transposons have become important vectors for efficient non-viral integration of transgenes into genomic DNA. The Sleeping Beauty (SB, piggyBac (PB, and Tol2 transposable elements have distinct biological properties and currently represent the most promising transposon systems for animal transgenesis and gene therapy. A potential obstacle, however, for persistent function of integrating vectors is transcriptional repression of the element and its genetic cargo. In this study we analyze the insulating effect of the 1.2-kb 5'-HS4 chicken β-globin (cHS4 insulator element in the context of SB, PB, and Tol2 transposon vectors. By examining transgene expression from genomically inserted transposon vectors encoding a marker gene driven by a silencing-prone promoter, we detect variable levels of transcriptional silencing for the three transposon systems in retinal pigment epithelium cells. Notably, the PB system seems less vulnerable to silencing. Incorporation of cHS4 insulator sequences into the transposon vectors results in 2.2-fold and 1.5-fold increased transgene expression levels for insulated SB and PB vectors, respectively, but an improved persistency of expression was not obtained for insulated transgenes. Colony formation assays and quantitative excision assays unveil enhanced SB transposition efficiencies by the inclusion of the cHS4 element, resulting in a significant increase in the stable transfection rate for insulated SB transposon vectors in human cell lines. Our findings reveal a positive impact of cHS4 insulator inclusion for SB and PB vectors in terms of increased transgene expression levels and improved SB stable transfection rates, but also the lack of a long-term protective effect of the cHS4 insulator against progressive transgene silencing in retinal pigment epithelium cells.
徐旭赟; 黄美英
2015-01-01
Objective To evaluate the value of combined detection of high sensitivity C-reactive protein ( hs-CRP ) and homocysteine (Hcy) levels in diagnosing gestational diabetes mellitus (GDM) and its value on predicting pregnancy outcomes. Methods Thirty-five women with GDM accepting pre-natal screening in Third People’ s Hospital of Anji County from January 2012 to March 2014 were selected in observation group. Another 35 healthy women diagnosed without GDM at the same period were selected in control group. The levels of hs-CRP, Hcy, fasting plasma glucose ( FPG) and fasting insulin ( FINS) in two groups were detected and compared, and the pregnancy outcomes were followed up. Results The levels of FPG, FINS, hs-CRP and Hcy in the observation group were higher than those in the control group, and the differences were significant (t value was 13. 07, 12. 02, 3. 65 and 12. 02, respectively, all P <0. 05). The incidence of adverse reactions was 34. 3% (12/35) and 11. 4% (4/35) in the observation group and the control group, respectively with statistical significance (χ2 =5. 19,P<0. 05). Sixteen cases were found with adverse pregnancy outcomes, and their hs-CRP and Hcy levels were higher than those of 54 normal pregnant women (t value was 7. 88 and 14. 17, respectively, both P<0. 05). Conclusion The levels of hs-CRP and Hcy are closely related with GDM, and the high levels have predictive value for adverse pregnancy outcomes. Therefore, attention should be attracted on them.%目的：探讨联合检测超敏C反应蛋白( hs-CRP)和同型半胱氨酸( Hcy)水平在妊娠期糖尿病( GDM)诊断及对妊娠结局的预测价值。方法选择2012年1月至2014年3月在安吉县第三人民医院门诊接受检查的GDM患者35例作为观察组；选择同期经临床排除GDM的正常孕产妇35例作为对照组。检测两组患者的hs-CRP和Hcy、空腹血糖和胰岛素水平,并跟踪两组妊娠结局。结果观察组患者空腹血糖、胰岛素、hs-CRP 和 Hcy
李方江; 王晓元; 张文婷; 杜美玲; 李清; 张强; 李慧敏
2015-01-01
目的：探讨冠心病患者外周血高敏C反应蛋白（hs CRP ）、氧化型低密度脂蛋白（ox LDL ）和同型半胱氨酸（Hcy ）水平及其意义。方法选取经冠状动脉造影检查证实冠心病组272例，分为急性心肌梗死（AMI ）组105例，不稳定型心绞痛（UA ）组126例，稳定型心绞痛（SAP ）组41例；选取冠状动脉造影证实冠状动脉无狭窄病变56例为对照组。采集研究对象入院24小时内静脉血，ELISA法检测ox LDL水平，日立7070型全自动生化分析仪测定hs CRP、Hcy、总胆固醇（TC ）、甘油三脂（TG ）、低密度脂蛋白（LDL ）指标。结果冠心病组血清hs CRP、ox LDL、Hcy水平显著高于对照组，差异有统计学意义（ P＜0.01）；AMI组血清hs CRP、ox LDL、Hcy水平显著高于SAP组，差异有统计学意义（ P＜0.05）；AMI组血清hs CRP、ox LDL水平显著高于UA组，差异有统计学意义（ P＜0.05）。结论联合检测hs CRP、ox LDL、Hcy有助于对冠心病的诊断。%Objective To investigate the level and significance of peripheral high sensitivity C reactive protein (hs CRP ) ,oxidized low density lipoprotein (ox LDL ) and homocysteine (Hcy ) in patients with coronary heart disease. Methods 272 patients with coro-nary heart disease were selected ,which confirmed by coronary angiography , including 105 cases of acute myocardial infarction (AMI) ,126 cases of unstable angina (UA) and 41 cases of stable angina patients (SAP). The control group included 56 patients with no coronary artery stenosis confirmed by coronary angiography . Collected the fasting blood of patients within 24 hours of admis-sion ,the levels of ox LDL was detected by ELISA ,and the determination of hs CRP、Hcy、total cholesterol ,triglycerides ,LDL index was detected by Hitachi 7070 automatic biochemical analyzer. Results The serum levels of hs CRP、ox LDL、Hcy in the grope of coro-nary heart disease were significantly higher than
Kelsall, G.H.; Thompson, I. (Imperial College, London (United Kingdom). Dept. of Mineral Resources Engineering)
1993-04-01
Electrochemical techniques were used to study the oxidation of HS[sup -] ions at pH 9.3. Voltammetry of gold electrodes in HS[sup -]-containing solutions showed that multilayers of sulphur and soluble oxidation products were formed. As a known HS[sup -] oxidation product, thiosulphate solutions were also studied voltammetrically, but found to be electro-inactive at mildly oxidising potentials. The voltammetric behaviour of polysulphide ions, S[sub n][sup 2-] (n = 2 to 5), was similar to that of HS[sup -] solutions on oxidation, though they could be reduced to HS[sup -] ions at low potentials. Ring-disc electrode experiments, extending the HS[sup -] concentration range that had been studied previously, confirmed that polysulphide ions were produced on reduction of anodically deposited elemental sulphur. This was demonstrated in both cyclic voltammetry and potential step experiments. (author)
HS-SPME-GC-MS分析螺旋藻挥发性成分%Analysis of Volatile Components of Spirulina by HS-SPME-GC-MS
张丽君; 许柏球; 王金林; 罗欢忠; 陈晚霞; 林伟强
2013-01-01
The Spirulina platensis was selected as material and the odor flavor components was analyzed .The volatile components was determined by Headspace solid phase microextraction combined with gas hromatography mass spectrometry (HS-SPME-GC-MS).The results showd that 17 volatile components were indentified,including alkanes (relative content 79.77%), aldehydes and ketones (relative content 18.27%), alcohols (relative content 0.84 %) and aromatic compounds (relative content 1.17 %). The main volatile components of Spirulina platensis were Heptadecane (relative content 64.52 %), Pentadecane ( relative content8.59%), Dihydroactinidiolide (relative content 7.21%) ,β-ionone ( relative content 6.65%) and Hexadecane (relative content4.29%).% 以钝顶螺旋藻藻粉为原料，对其腥味物质进行分析。采用顶空固相微萃取和气相色谱-质谱联用技术，对钝顶螺旋藻的挥发性成分进行检测，共鉴定出17种有机化合物，烷烃类化合物（相对含量79.77%）、醛酮类化合物（相对含量18.27%）、醇类化合物（相对含量0.84%）、芳香族化合物（相对含量1.17%）。螺旋藻的主要挥发成分依次为十七烷（平均相对含量为64.52%）、十五烷（平均相对含量为8.59%）、二氢猕猴桃内酯（平均相对含量为7.21%）、β-紫罗兰酮（平均相对含量为6.65%）和十六烷（平均相对含量为4.29%）。
Freche, J. C.; Ashbrook, R. L.
1973-01-01
The cobalt-base alloy HS-31 was atomized into powder and then consolidated by extrusion or by hot isostatic pressing (HIP) in an autoclave over a range of temperatures spanning the solidus, approximately 2340 F. Extrusions were subsequently autoclaved at the same conditions. Extrusions autoclaved at 2420 F had a life of 300 hours at 1200 F and 30 hours at 1800 F at stresses that result in a 10-hour life with cast HS-31. Superior stress rupture lives of autoclaved material are probably related to the solidification structure at the grain boundaries as well as to the increased grain size.
Mercier, Marie Le; Fortin, Shannon; Mathieu, Véronique; Roland, Isabelle; Spiegl-Kreinecker, Sabine; Haibe-Kains, Benjamin; Bontempi, Gianluca; Decaestecker, Christine; Berger, Walter; Lefranc, Florence; Kiss, Robert
2009-01-01
We have previously reported that galectin 1 (Gal-1) plays important biological roles in astroglial as well as in oligodendroglial cancer cells. As an oligodendroglioma model, we make use of the Hs683 cell line that has been previously extensively characterized at cell biology, molecular biology, and genetic levels. Galectin 1 has been shown to be involved in Hs683 oligodendroglioma chemoresistance, neoangiogenesis, and migration. Down-regulating Gal-1 expression in Hs683 cells through targete...
Kim, Min-Gul; Cho, Baik-Hwan; Chae, Soo-Wan; Park, Tae-Sun; Kim, Dal-Sik
2015-01-01
Background Systemic low-grade inflammation (SLGI), as assessed by measurements of high-sensitivity C-reactive protein (hs-CRP), is a strong independent risk factor for cardiovascular diseases (CVD). Although individuals with hs-CRP ≤ 1 mg/L have been defined as being at low risk according to AHA/CDC guidelines, the value of very low hs-CRP levels (
Ping Kei Chan
Full Text Available Hypersensitive site 5 (5'HS5 of the beta-globin Locus Control Region functions as a developmental stage-specific border in erythroid cells. Here, we have analyzed the role of 5'HS5 in the three dimensional organization of the beta-gene locus using the Chromatin Conformation Capture (3C technique. The results show that when 5'HS5 is deleted from the locus, both remote and internal regulatory elements are still able to interact with each other in a three-dimensional configuration termed the Active Chromatin Hub. Thus, the absence of 5'HS5 does not have an appreciable effect on the three dimensional organization of the beta-globin locus. This rules out models in which 5'HS5 nucleates interactions with remote and/or internal regulatory elements. We also determined the binding of CTCF, the only defined insulator protein in mammalian cells, to 5'HS5 by using chromatin immunoprecipitation (ChIP assays. We detect low levels of CTCF binding to 5'HS5 in primitive erythroid cells, in which it functions as a border element. Surprisingly, we also observe binding levels of CTCF to 5'HS5 in definitive erythroid cells. Thus, binding of CTCF to 5'HS5 per se does not render it a functional border element. This is consistent with the previous data suggesting that CTCF has dual functionality.
Wai Kit Chan
Full Text Available Heparan sulfate (HS is a linear carbohydrate composed of polymerized uronate-glucosamine disaccharide units that decorates cell surface and secreted glycoproteins in the extracellular matrix. In mammals HS is subjected to differential sulfation by fifteen different heparan sulfotransferase (HST enzymes of which Hs2st uniquely catalyzes the sulfation of the 2-O position of the uronate in HS. HS sulfation is postulated to be important for regulation of signaling pathways by facilitating the interaction of HS with signaling proteins including those of the Fibroblast Growth Factor (Fgf family which signal through phosphorylation of extracellular signal-regulated kinases Erk1/2. In the developing mouse telencephalon Fgf2 signaling regulates proliferation and neurogenesis. Loss of Hs2st function phenocopies the thinned cerebral cortex of mutant mice in which Fgf2 or Erk1/2 function are abrogated, suggesting the hypothesis that 2-O-sulfated HS structures play a specific role in Fgf2/Erk signaling pathway in this context in vivo. This study investigated the molecular role of 2-O sulfation in Fgf2/Erk signaling in the developing telencephalic midline midway through mouse embryogenesis at E12.5. We examined the expression of Hs2st, Fgf2, and Erk1/2 activity in wild-type and Hs2st-/- mice. We found that Hs2st is expressed at high levels at the midline correlating with high levels of Erk1/2 activation and Erk1/2 activation was drastically reduced in the Hs2st-/- mutant at the rostral telencephalic midline. We also found that 2-O sulfation is specifically required for the binding of Fgf2 protein to Fgfr1, its major cell-surface receptor at the rostral telencephalic midline. We conclude that 2-O sulfated HS structures generated by Hs2st are needed to form productive signaling complexes between HS, Fgf2 and Fgfr1 that activate Erk1/2 at the midline. Overall, our data suggest the interesting possibility that differential expression of Hs2st targets the rostral
LDL-C和hs-CRP在急性冠脉综合征诊断中的价值%Diagnosis value of LDL-C and hs-CRP in acute coronary syndrome
叶碧宁
2012-01-01
目的 分析研究低密度脂蛋白胆固醇(LDL-C)、血清高敏C 反应蛋白(hs-CRP)对急性冠脉综合征(ACS)的临床诊断价值.方法 选择2009年9月至2010年9月期间该院心内科收治的84例ACS患者作为研究组,并选择同时期门诊体检的84例健康者作为对照组,分别用免疫比浊法检测两组的血清hs-CRP水平,速率法检测LDL-C水平,并分析计算LDL-C和hs-CRP在诊断ACS方面的效能.结果 研究组血清LDL-C和hs-CRP的浓度明显高于对照组的(P<0.05).单独LDL-C诊断ACS的敏感性与特异性分别为51.2%和82.3%,阳性和阴性预测值分别为75.9%和55.3%.单独hs-CRP诊断ACS的敏感性与特异性分别为48.8%和85.6%,阳性和阴性预测值分别为73.8%和52.9%.LDL-C和hs-CRP联合诊断ACS的阳性例数为82例,与单独LDL-C诊断的阳性例数差异有显著性(χ2=6.41,P＜0.05),与单独hs-CRP诊断的阳性例数也差异有显著性(χ2=6.63,P＜0.05),敏感性与特异性分别为95.6%和46.3%,阳性和阴性预测值分别为65.6%和91.2%.结论 联合检测LDL-C和hs-CRP可有助于早期诊断ACS.%Objective To explore detection value of low-density lipoprotein cholesterol( LDL-C ) and high sensitive C-reactive protein ( hs-CRP ) in the diagnosis of acute coronary syndrome( ACS ). Methods Eighty-four cases of ACS as the research group were collected and 84 healthy people as the control group were collected. Serum hs-CRP levels of the two groups were tested by immune turbidimetry method, and LDL-C levels were tested by rate method. Efficiency of hs-CRP level and LDL-C level in the diagnosis of ACS was analyzed. Results The levels of LDL-C and hs-CRP of the research group were significantly higher than those in the control group, with P <0. 05. The sensitivity and specificity of LDL-C in the diagnosis of ACS was 51. 2% and 82. 3% , positive and negative predictive value was 75. 9% and 55. 3% . The sensitivity and specificity of hs-CRP in the diagnosis of ACS was 48. 8% and 85
Cagnetti, Filippo
2013-11-01
We consider a numerical scheme for the one dimensional time dependent Hamilton-Jacobi equation in the periodic setting. This scheme consists in a semi-discretization using monotone approximations of the Hamiltonian in the spacial variable. From classical viscosity solution theory, these schemes are known to converge. In this paper we present a new approach to the study of the rate of convergence of the approximations based on the nonlinear adjoint method recently introduced by L.C. Evans. We estimate the rate of convergence for convex Hamiltonians and recover the O(h) convergence rate in terms of the L∞ norm and O(h) in terms of the L1 norm, where h is the size of the spacial grid. We discuss also possible generalizations to higher dimensional problems and present several other additional estimates. The special case of quadratic Hamiltonians is considered in detail in the end of the paper. © 2013 IMACS.
Shuhuan Wen
2012-01-01
Full Text Available This paper works on hybrid force/position control in robotic manipulation and proposes an improved radial basis functional (RBF neural network, which is a robust relying on the Hamilton Jacobi Issacs principle of the force control loop. The method compensates uncertainties in a robot system by using the property of RBF neural network. The error approximation of neural network is regarded as an external interference of the system, and it is eliminated by the robust control method. Since the conventionally fixed structure of RBF network is not optimal, resource allocating network (RAN is proposed in this paper to adjust the network structure in time and avoid the underfit. Finally the advantage of system stability and transient performance is demonstrated by the numerical simulations.
McGann, M; Dewar, R L; von Nessi, G
2010-01-01
The vanishing of the divergence of the total stress tensor (magnetic plus kinetic) in a neighborhood of an equilibrium plasma containing a toroidal surface of discontinuity gives boundary and jump conditions that strongly constrain allowable continuations of the magnetic field across the surface. The boundary conditions allow the magnetic fields on either side of the discontinuity surface to be described by surface magnetic potentials, reducing the continuation problem to that of solving a Hamilton--Jacobi equation. The characteristics of this equation obey Hamiltonian equations of motion, and a necessary condition for the existence of a continued field across a general toroidal surface is that there exist invariant tori in the phase space of this Hamiltonian system. It is argued from the Birkhoff theorem that existence of such an invariant torus is also, in general, sufficient for continuation to be possible. An important corollary is that the rotational transform of the continued field on a surface of disco...
无
2000-01-01
It is proved that if f is a Teichmüller self-mapping of the unit disk with a holomorphic quadratic differential φ1, and φ satisfies the growth condition m(φ,r) = 1/2π f02π |φ(reiθ)| dθ =o((1 - r)-s), r → 1, for any s ＞ 1, then f is extremal, and there exists a sequence {tn}, 0 ＜ tn ＜ 1, lim tn = 1, such that {φ(tnz)} is a Hamilton sequence. It is the precision of a n→∞ theorem of Reich-Strebel in 1974, and gives a fairly satisfactory answer to a question of Reich in 1988.
Kovach, Ryan P.; Luikart, Gordon; Lowe, Winsor H.; Boyer, Matthew C.; Muhlfeld, Clint C.
2016-01-01
Hamilton and Miller (2016) provide an interesting and provocative discussion of how hybridization and introgression can promote evolutionary potential in the face of climate change. They argue that hybridization—mating between individuals from genetically distinct populations—can alleviate inbreeding depression and promote adaptive introgression and evolutionary rescue. We agree that deliberate intraspecific hybridization (mating between individuals of the same species) is an underused management tool for increasing fitness in inbred populations (i.e., genetic rescue; Frankham 2015; Whiteley et al. 2015). The potential risks and benefits of assisted gene flow have been discussed in the literature, and an emerging consensus suggests that mating between populations isolated for approximately 50–100 generations can benefit fitness, often with a minor risk of outbreeding depression (Frankham et al. 2011; Aitken & Whitlock 2013; Allendorf et al. 2013).
Hamilton-Jacobi method and effective actions of D-brane and M-brane in supergravity
Sato, Matsuo E-mail: machan@het.phys.sci.osaka-u.ac.jp; Tsuchiya, Asato E-mail: tsuchiya@het.phys.sci.osaka-u.ac.jp
2003-11-03
We show that the effective actions of D-brane and M-brane are solutions to the Hamilton-Jacobi (H-J) equations in supergravities. This fact means that these effective actions are on-shell actions in supergravities. These solutions to the H-J equations reproduce the supergravity solutions that represent D-branes in a B{sub 2} field, M2 branes and the M2-M5 bound states. The effective actions in these solutions are those of a probe D-brane and a probe M-brane. Our findings can be applied to the study of the gauge/gravity correspondence, especially the holographic renormalization group, and a search for new solutions of supergravity.
Sakalli, I., E-mail: izzet.sakalli@emu.edu.tr; Mirekhtiary, S. F., E-mail: fatemeh.mirekhtiary@emu.edu.tr [Eastern Mediterranean University G. Magosa, Department of Physics (Turkey)
2013-10-15
Hawking radiation of a non-asymptotically flat 4-dimensional spherically symmetric and static dilatonic black hole (BH) via the Hamilton-Jacobi (HJ) method is studied. In addition to the naive coordinates, we use four more different coordinate systems that are well-behaved at the horizon. Except for the isotropic coordinates, direct computation by the HJ method leads to the standard Hawking temperature for all coordinate systems. The isotropic coordinates allow extracting the index of refraction from the Fermat metric. It is explicitly shown that the index of refraction determines the value of the tunneling rate and its natural consequence, the Hawking temperature. The isotropic coordinates in the conventional HJ method produce a wrong result for the temperature of the linear dilaton. Here, we explain how this discrepancy can be resolved by regularizing the integral possessing a pole at the horizon.
Sakalli, I.; Mirekhtiary, S. F.
2013-10-01
Hawking radiation of a non-asymptotically flat 4-dimensional spherically symmetric and static dilatonic black hole (BH) via the Hamilton-Jacobi (HJ) method is studied. In addition to the naive coordinates, we use four more different coordinate systems that are well-behaved at the horizon. Except for the isotropic coordinates, direct computation by the HJ method leads to the standard Hawking temperature for all coordinate systems. The isotropic coordinates allow extracting the index of refraction from the Fermat metric. It is explicitly shown that the index of refraction determines the value of the tunneling rate and its natural consequence, the Hawking temperature. The isotropic coordinates in the conventional HJ method produce a wrong result for the temperature of the linear dilaton. Here, we explain how this discrepancy can be resolved by regularizing the integral possessing a pole at the horizon.
Sakalli, I
2013-01-01
Hawking radiation of a non-asymptotically flat (NAF) 4-dimensional spherically symmetric and static dilatonic black hole (BH) via the Hamilton-Jacobi (HJ) method has been studied. In addition to the naive coordinates, we have used four more different coordinate systems which are well-behaved at the horizon. Except the isotropic coordinates, direct computation of the HJ method leads us the standard Hawking temperature for all coordinate systems. The isotropic coordinates render possible to get the index of refraction extracting from the Fermat metric. It is explicitly shown that the index of refraction determines the value of the tunneling rate and its natural consequence, Hawking temperature. The isotropic coordinates within the conventional HJ method produce wrong result for the temperature of the LDBH. Here, we explain how this discrepancy can be resolved by regularizing the integral possessing a pole at the horizon.
Rahman, M Atiqur
2013-01-01
The massive particles tunneling method has been used to investigate the Hawking non-thermal and purely thermal radiations of Schwarzschild Anti-de Sitter (SAdS) black hole. Considering the spacetime background to be dynamical, incorporate the self-gravitation effect of the emitted particles the imaginary part of the action has been derived from Hamilton-Jacobi equation. Using the conservation laws of energy and angular momentum we have showed that the non-thermal and purely thermal tunneling rates are related to the change of Bekenstein-Hawking entropy and the derived emission spectrum deviates from the pure thermal spectrum. The result obtained for SAdS black hole is also in accordance with Parikh and Wilczek\\rq s opinion and gives a correction to the Hawking radiation of SAdS black hole.
Hamilton-Jacobi method and effective actions of D-brane and M-brane in supergravity
Sato, Matsuo; Tsuchiya, Asato
2003-11-01
We show that the effective actions of D-brane and M-brane are solutions to the Hamilton-Jacobi (H-J) equations in supergravities. This fact means that these effective actions are on-shell actions in supergravities. These solutions to the H-J equations reproduce the supergravity solutions that represent D-branes in a B2 field, M2 branes and the M2-M5 bound states. The effective actions in these solutions are those of a probe D-brane and a probe M-brane. Our findings can be applied to the study of the gauge/gravity correspondence, especially the holographic renormalization group, and a search for new solutions of supergravity.
Rahman, M. Atiqur; Hossain, M. Ilias
2013-06-01
The massive particles tunneling method has been used to investigate the Hawking non-thermal and purely thermal radiations of Schwarzschild Anti-de Sitter (SAdS) black hole. Considering the spacetime background to be dynamical, incorporate the self-gravitation effect of the emitted particles the imaginary part of the action has been derived from Hamilton-Jacobi equation. Using the conservation laws of energy and angular momentum we have showed that the non-thermal and purely thermal tunneling rates are related to the change of Bekenstein-Hawking entropy and the derived emission spectrum deviates from the pure thermal spectrum. The result obtained for SAdS black hole is also in accordance with Parikh and Wilczek's opinion and gives a correction to the Hawking radiation of SAdS black hole.
Salisbury, Donald; Sundermeyer, Kurt
2015-01-01
Classical background independence is reflected in Lagrangian general relativity through covariance under the full diffeomorphism group. We show how this independence can be maintained in a Hamilton-Jacobi approach that does not accord special privilege to any geometric structure. Intrinsic spacetime curvature based coordinates grant equal status to all geometric backgrounds. They play an essential role as a starting point for inequivalent semi-classical quantizations. The scheme calls into question Wheeler's geometrodynamical approach and the associated Wheeler-DeWitt equation in which three-metrics are featured geometrical objects. The formalism deals with variables that are manifestly invariant under the full diffeomorphism group. Yet, perhaps paradoxically, the liberty in selecting intrinsic coordinates is precisely as broad as is the original diffeomorphism freedom. We show how various ideas from the past five decades concerning the true degrees of freedom of general relativity can be interpreted in light...
九节点Hamilton等参元列式%9-node Isoparametric Element of Hamilton Canonical Equation
邢瑞山; 卿光辉
2012-01-01
结合弹性材料修正后的H-R变分原理和九节点四边形等参元二次插值函数,建立了九节点Hamilton等参元列式的正则方程.简要地介绍了弹性材料修正后的H-R变分原理.基于变分原理使用3×3的高斯积分详细地推导了Hamilton正则方程的九节点等参元列式,使得九节点等参元在有限元法中的优越性与弹性力学Hamihon正则方程的半解析法得到了有机的结合.数值实例的结果证明了本文九节点Hamilton等参元列式的正确性.%The 9-node isoparametric element of Hamiltonian canonical equation has been established by combining the modified Hellinger-Reissner (H-R) variational principle of elastic material and quadratic interpolation function of 9-node quadrilateral isoparametric element. Firstly, the modified H-R variational principle for the elastic material was briefly presented. Then, based on the variational principle and the 3 ×3 Guass integration, the Hamilton canonical equation of 9-node isoparametric element was derived in detail. The advantages of 9-node isoparametric element in finite element were combined with the semi-analytical method of elasticity Hamilton canoncial equation organically. The results of numerical examples prove the correctness of the 9-node isoparametric element formulation.
周金锋; 程自平
2013-01-01
目的 探讨B型钠尿肽前体(NT-ProBNP)和高敏C反应蛋白(hs-CRP)联合检测对心力衰竭诊断、病情评估和预后判断的价值.方法 测定该院2010年1月-2012年11月103例明确诊断为充血性心力衰竭(CHF)的患者,测定入院时、出院时血浆NT-ProBNP 和血清hs-CRP水平,进行治疗前后对比观察,并随机抽取该院35名健康体检者作对照组比较,随访6月观察患者心脏事件再发生的情况.结果 血浆NT-ProBNP和血清hs-CRP和水平在心衰不同心功能分级组和健康对照组之间差异有统计学意义,心功能越差,其浓度越高(P<0.05);治疗前后比较,差异均也有统计学意义(P<0.05);出院后发生心脏事件组血浆NT-ProBNP 和血清hs-CRP水平浓度明显高于未发生心脏事件组(P<0.05).结论 心衰患者中NT-ProBNP 、hs-CRP明显升高,二者联合检测对心衰诊断、病情评估和预后判断有应用意义.%Objective To observe the value of B-type natriuretic peptide precursor (NT -ProBNP)and high-sensitivity C-eactive protein (hs-CRP)on patients of heart failure in diagnosis , illness evaluation and prognosis through jointed detection . Methods From January 2010 to November 2012,103 cases of CHF patients were measured plasma NT -ProBNP and hs -CRP serum levels on admission and at discharge. Before and after treatment comparison observations were made ,35 health were selected randomly for control. The patients were followed up for 6 months to observe it cardiac events happen again . Results NT-ProBNP and hs -CRP serum and plasma levels in different heart failure cardiac function grading group had statistically significant difference from healthy control group . The poorer heart function , the higher concentration ( P < 0.05 ) ; Before and after treatment, difference had statistical significance ( P < 0.05 ) ; Concentrations of plasma NT -ProBNP and hs -CRP level were significantly higher in cardiac evento after discharge group than those without cardiac
张丽娜; 寇筱囡; 李新娜; 曹艳菲; 车璐
2014-01-01
目的：探讨超敏C反应蛋白（high-sensitivity C-reactive protein, hs-CRP）作为肥胖青少年心血管疾病发病风险的生物标志物的评估价值。方法6-18岁青少年，体重指数（body mass index, BMI）超过2 SDS。所有入组对象空腹12h采集静脉血，检测hs-CRP，肝脏功能检测，血脂检测，尿酸等检测；糖耐量试验。我们认为肥胖青少年存在代谢综合征症状，至少包括两个以下症状：高甘油三酯血症、低高密度脂蛋白胆固醇（high density lipoprotein cholesterol, HDL-C）、高血压及糖代谢障碍。结果115例青少年患者中，24%显示存在代谢综合症，存在代谢综合症的患者血清hs-CRP水平（M=3.8ml/L；95% CI：2.9-4.8）高与不存在代谢综合征症状的肥胖青少年（M=1.9ml/L；95% CI：1.5-2.5），经多变量分析，影响hs-CRP水平的是BMI、甘油三酯、HDL-C水平。讨论血清hs-CRP是判断肥胖青少年是否存在早期心血管疾病发生风险的有价值的生物标志物。%Objective To assess the utility of the high -sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese teenagers. Methods The study included teenagers between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. Al the patients had their blood pressure taken and hs-CRP, hepatic function, lipid and uric acid were determined after 12 h of fasting, likewise , an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. Results Out of the 115 obese teenagers 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (M=3.8ml/L; 95% CI: 2.9-4.8) in comparison with the obese patients who did not show signs of metabolic syndrome(M=1.9ml/L; 95% CI: 1.5-2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-C levels. Conclusions The hs-CRP is
丁金凤; 金世欣; 张毅
2016-01-01
The fractional Noether symmetries and fractional conserved quantities for Hamilton system with time delay based on Caputo derivatives are discussed.The fractional Hamilton canonical equations of the corresconding system with time delay are established base upon the fractional Hamilton principle of the Hamilton systems with time delay.Then,the fractional Noether symmetries of the Hamilton system with time delay are obtained,which based on the invariance of the fractional Hamilton action with time delay under the infinitesimal transformations of group.Finally,fractional Noether theorems with time delay of the Hamilton system are established.At the end,one example is given to illustrate the application of the results.%提出并讨论了Caputo导数定义下的含时滞的Hamilton系统的分数阶Noether对称性与守恒量。根据含时滞的Hamilton系统的分数阶Hamilton原理，建立了相应的含时滞的分数阶Hamilton 正则方程；依据分数阶Hamilton作用量在无限小变换下的不变性，得到了含时滞的Hamilton系统的分数阶Noether对称性；最后，建立了系统的含时滞的分数阶Noether理论，并举例说明结果的应用。
Ma, Yi; Ghoshdastider, Umesh; Wang, Jufang; Ye, Wei; Dötsch, Volker; Filipek, Slawomir; Bernhard, Frank; Wang, Xiaoning
2012-12-01
Glucosamine 6-phosphate N-acetyltransferase (GNA1; EC 2.3.1.4) is required for the de novo synthesis of N-acetyl-d-glucosamine-6-phosphate (GlcNAc-6P), which is an essential precursor in Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) biosynthesis pathway. Therefore, GNA1 is indispensable for the viability of organisms. Here, a novel cell-free expression strategy was developed to efficiently produce large amounts of human GNA1(HsGNA1) and HsGNA1-sGFP for throughput inhibitor screening. The binding site of inhibitor glucose-6-phosphate (G6P) to hGNA was identified by simulated annealing. Subtle differences to the binding site of Aspergillius GNA1(AfGNA1) can be harnessed for inhibitor design. HsGNA1 may be also useful as an antimicrobial and chemotherapeutic target against cancer. Additionally HsGNA1 inhibitors/modulators can possibly be administered with other drugs in the next generation of personalized medicine.
Junca, Pierre; Sandoz, Jean-Christophe
2015-01-01
The recent development of the olfactory conditioning of the sting extension response (SER) has provided new insights into the mechanisms of aversive learning in honeybees. Until now, very little information has been gained concerning US detection and perception. In the initial version of SER conditioning, bees learned to associate an odor CS with an electric shock US. Recently, we proposed a modified version of SER conditioning, in which thermal stimulation with a heated probe is used as US. This procedure has the advantage of allowing topical US applications virtually everywhere on the honeybee body. In this study, we made use of this possibility and mapped thermal responsiveness on the honeybee body, by measuring workers' SER after applying heat on 41 different structures. We then show that bees can learn the CS-US association even when the heat US is applied on body structures that are not prominent sensory organs, here the vertex (back of the head) and the ventral abdomen. Next, we used a neuropharmalogical approach to evaluate the potential role of a recently described Transient Receptor Potential (TRP) channel, HsTRPA, on peripheral heat detection by bees. First, we applied HsTRPA activators to assess if such activation is sufficient for triggering SER. Second, we injected HsTRPA inhibitors to ask whether interfering with this TRP channel affects SER triggered by heat. These experiments suggest that HsTRPA may be involved in heat detection by bees, and represent a potential peripheral detection system in thermal SER conditioning.
Time delay in the variability of multiply lensed QSOs HS0810+2554 and Q2237+030
Storrs, Alex; Lainez, Sergio
2017-01-01
We present time delay in variability between the brightest lensed images of two multiply lensed QSO systems, HS0810+2554 and Q2237+030. This data can help constrain the mass distribution of the lensing galaxies, and perhaps on Hubble’s Constant as well. Observations were made with the Towson University 0.4m telescope.
Poultry products serve as the main source of Campylobacter jejuni subsp. jejuni (Cjj) infections in humans. Cjj infections are a leading cause of foodborne gastroenteritis and are a prevalent antecedent to Guillain-Barré syndrome (GBS). This study describes the genome of Cjj HS:19 strain RM1285 isol...
Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE−/− Mice
Asha Ford
2013-01-01
Full Text Available Hydrogen sulfide is emerging as an important mediator of vascular function that has antioxidant and cytoprotective effects. The aim of this study was to investigate the role of endogenous H2S and the effect of chronic exogenous H2S treatment on vascular function during the progression of atherosclerotic disease. ApoE−/− mice were fed a high-fat diet for 16 weeks and treated with the H2S donor NaHS or the cystathionine-γ-lyase (CSE inhibitor D,L-propargylglycine (PPG, to inhibit endogenous H2S production for the final 4 weeks. Fat-fed ApoE−/− mice displayed significant aortic atherosclerotic lesions and significantly impaired endothelial function compared to wild-type mice. Importantly, 4 weeks of NaHS treatment significantly reduced vascular dysfunction and inhibited vascular superoxide generation. NaHS treatment significantly reduced the area of aortic atherosclerotic lesions and attenuated systolic blood pressure. Interestingly, inhibiting endogenous, CSE-dependent H2S production with PPG did not exacerbate the deleterious vascular changes seen in the untreated fat-fed ApoE−/− mice. The results indicate NaHS can improve vascular function by reducing vascular superoxide generation and impairing atherosclerotic lesion development. Endogenous H2S production via CSE is insufficient to counter the atherogenic effects seen in this model; however exogenous H2S treatment has a significant vasoprotective effect.
Kazuki Saito
2013-04-01
Full Text Available Plants produce various volatile organic compounds (VOCs, which are thought to be a crucial factor in their interactions with harmful insects, plants and animals. Composition of VOCs may differ when plants are grown under different nutrient conditions, i.e., macronutrient-deficient conditions. However, in plants, relationships between macronutrient assimilation and VOC composition remain unclear. In order to identify the kinds of VOCs that can be emitted when plants are grown under various environmental conditions, we established a conventional method for VOC profiling in Arabidopsis thaliana (Arabidopsis involving headspace-solid-phase microextraction-gas chromatography-time-of-flight-mass spectrometry (HS-SPME-GC-TOF-MS. We grew Arabidopsis seedlings in an HS vial to directly perform HS analysis. To maximize the analytical performance of VOCs, we optimized the extraction method and the analytical conditions of HP-SPME-GC-TOF-MS. Using the optimized method, we conducted VOC profiling of Arabidopsis seedlings, which were grown under two different nutrition conditions, nutrition-rich and nutrition-deficient conditions. The VOC profiles clearly showed a distinct pattern with respect to each condition. This study suggests that HS-SPME-GC-TOF-MS analysis has immense potential to detect changes in the levels of VOCs in not only Arabidopsis, but other plants grown under various environmental conditions.
van der Velde, Marije; Bello, Aminu K.; Brantsma, Auke H.; El Nahas, Meguid; Bakker, Stephan J. L.; de Jong, Paul E.; Gansevoort, Ronald T.
2012-01-01
Background. To investigate the added value of elevated urinary albumin excretion (UAE) and high high-sensitive C-reactive protein (hs-CRP) in predicting new-onset type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD) and chronic kidney disease (CKD) in addition to the present metabolic syndr
Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome
Waode Nurfina
2010-12-01
Full Text Available BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS and correlate with the inflammation and oxidative stress. METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP and F2-Isoprostane. RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220 and F2-Isoprostane (r=0.023. CONCLUSIONS: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane. KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane.
Radhey Shyam Chejara
2015-06-01
Conclusion: At the end of the study we concluded that both a low serum free testosterone level and high hs-CRP concentration may play an important role in the pathogenesis of mild anemia and low hematocrit values in DM type 2 patients. [Int J Res Med Sci 2015; 3(6.000: 1501-1504
Gao, Mei-Yue; Qi, Huan; Li, Jian-Song; Zhang, Hui; Zhang, Ji; Wang, Ji-Dong; Xiang, Wen-Sheng
2017-09-01
A new naphthalenepropanoic acid analog (1) was isolated from the broth of the actinomycetes Micromonospora sp. HS-HM-036. The structure of compound 1 was determined based on MS and extensive NMR analysis. A preliminary investigation of the biological activity of compound 1 was also described.
Annarita Miccio
Full Text Available Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the HS2 enhancer of the GATA1 gene in protecting the expression of a β-globin minigene delivered by a lentiviral vector in hematopoietic stem/progenitor cells. Gene expression from proviruses carrying GATA1-HS2 in both LTRs was persistent and resistant to silencing at most integration sites in the in vivo progeny of human hematopoietic progenitors and murine long-term repopulating stem cells. The GATA1-HS2-modified vector allowed correction of murine β-thalassemia at low copy number without inducing clonal selection of erythroblastic progenitors. Chromatin immunoprecipitation studies showed that GATA1 and the CBP acetyltransferase bind to GATA1-HS2, significantly increasing CBP-specific histone acetylations at the LTRs and β-globin promoter. Recruitment of CBP by the LTRs thus establishes an open chromatin domain encompassing the entire provirus, and increases the therapeutic efficacy of β-globin gene transfer by reducing expression variegation and epigenetic silencing.
Azim, M.E.; Wahab, M.A.; Dam, van A.A.; Beveridge, M.C.M.; Verdegem, M.C.J.
2001-01-01
The effects of periphyton, grown on bamboo substrates, on growth and production of two Indian major carps, rohu, Labeo rohita (Hamilton) and gonia, Labeo gonius (Linnaeus), were studied at the Bangladesh Agricultural University, Mymensingh. For each species, five ponds were provided with bamboo subs
Bech, Per; Csillag, Claudio; Hellström, Lone;
2013-01-01
Objective: To use principal component analysis (PCA) to test the hypothesis that the items of the Hamilton Depression Scale (HAM-D17) have been selected to reflect depression disability, whereas some of the items are specific for sub-typing depression into typical vs. atypical depression. Method:...
Szigeti, Jeno
2011-01-01
If A is an n \\times n matrix over a ring R satisfying the polynomial identity [x,y][u,v]=0, then an invariant Cayley-Hamilton identity of the form \\Sigma A^{i}c_{i,j}A^{j}=0 with c_{i,j}\\in R and c_{n,n}=(n!)^2 holds for A.
Osetrin, Konstantin; Osetrin, Evgeny
2015-01-01
The characteristics of dust matter in space-time models, admitting the existence of privilege coordinate systems are given, where the single-particle Hamilton-Jacobi equation can be integrated by the method of complete separation of variables. The resulting functional form of the 4-velocity field and energy density of matter for all types of spaces under consideration is presented.
NONE
1996-02-01
The decision document presents the selected remedial action for Operable Unit 1 of the FEMP site in Hamilton and Butler Counties, Ohio. Operable Unit 1 consists of Waste Pits 1 through 6, the Burn Pit, the Clearwell, and associated environmental media (excluding groundwater).
Swenson, Sarah A
2015-12-01
W.D. Hamilton's theory of inclusive fitness saw the evolution of altruism from the point of view of the gene. It was at heart a theory of limits, redefining altruistic behaviours as ultimately selfish. This theory inspired two controversial texts published almost in tandem, E.O. Wilson's Sociobiology: The New Synthesis (1975) and Richard Dawkins's The Selfish Gene (1976). When Wilson and Dawkins were attacked for their evolutionary interpretations of human societies, they claimed a distinction between reporting what is and declaring what ought to be. Can the history of sociobiological theories be so easily separated from its sociopolitical context? This paper draws upon unpublished materials from the 1960s and early 1970s and documents some of the ways in which Hamilton saw his research as contributing to contemporary concerns. It pays special attention to the 1969 Man and Beast Smithsonian Institution symposium in order to explore the extent to which Hamilton intended his theory to be merely descriptive versus prescriptive. From this, we may see that Hamilton was deeply concerned about the political chaos he perceived in the world around him, and hoped to arrive at a level of self-understanding through science that could inform a new social order.
Molnár, Orsolya; Bajer, Katalin; Mészáros, Boglárka; Török, János; Herczeg, Gábor
2013-06-01
During female mate choice, conspicuous male sexual signals are used to infer male quality and choose the best sire for the offspring. The theory of parasite-mediated sexual selection (Hamilton-Zuk hypothesis) presumes that parasite infection can influence the elaboration of sexual signals: resistant individuals can invest more energy into signal expression and thus advertise their individual quality through signal intensity. By preferring these males, females can provide resistance genes for their offspring. Previous research showed that nuptial throat colour of male European green lizard, Lacerta viridis, plays a role in both inter- and intrasexual selections as a condition-dependent multiple signalling system. The aim of this study was to test the predictions of the Hamilton-Zuk hypothesis on male European green lizards. By blood sampling 30 adult males during the reproductive season, we found members of the Haemogregarinidae family in all but one individual (prevalence = 96%). The infection intensity showed strong negative correlation with the throat and belly colour brightness in line with the predictions of the Hamilton-Zuk hypothesis. In addition, we found other correlations between infection intensity and other fitness-related traits, suggesting that parasite load has a remarkable effect on individual fitness. This study shows that throat patch colour of the European green lizards not only is a multiple signalling system but also possibly acts as an honest sexual signal of health state in accordance with the Hamilton-Zuk hypothesis.
HS-SPME/GC-MS分析发酵人参香气成分%Analysis of Volatile Components of Fermented Panax Ginseng by HS-SPME/GC-MS
柴贺; 周亚楠; 初琦; 王玉华; 朴春红
2016-01-01
研究Kefir粒发酵对人参香气成分产生的影响.鲜人参经预处理后进行Kefir粒无氧和有氧发酵,利用顶空固相微萃取与气质联用相结合的方法优化顶空萃取头类型、萃取时间、萃取温度,再分析发酵前后人参香气成分的变化.结果表明:萃取头类型为非键合型PDMS(聚二甲基硅氧烷,涂层厚度100μm)、萃取时间为30 min,萃取温度为75℃时萃取效果最佳.该条件下未发酵人参香气共50种,其中烷烃类21种,萜烯类18种,醇类4种,醛酮类2种,酚类2种,芳香类1种,含氮杂环化合物2种,人参呈土腥味;Kefir粒无氧发酵人参香气成分共64种,其中烷烃类22种,萜烯类21种,醇类9种,醛酮类4种,芳香类3种,酯类2种,酚类1种,含氮杂环化合物2种,发酵后的人参呈果香和朗姆味;Kefir粒有氧发酵人参香气成分共64种,其中烷烃19种,萜烯类22种,醇类8种,醛酮类4种,芳香类2种,酯类3种,酚酸类2种,含氮杂环化合物4种,发酵后的人参呈草药味和烧烤香味.Kefir发酵人参显著提高了人参的芳香气味.%In order to study on the effect of Kefir fermented ginseng on the aroma components of panax ginseng, headspace solid-phase microextraction (HS-SPME) and gas chromatograph coupled with mass spectrometry (GC-MS) were used for the qualitative determination of volatile components in ginseng, anaerobic fermented ginseng and aerobic fermented ginseng. The conditions of SPME fiber type, extraction time and equilibrium temperature were optimized. Optimum adsorption was achieved using PDMS (100μm) fiber for adsorption at 75 ℃for 30 min. As a result, 50 aroma compounds were extracted out of the ginseng, including 21 alkanes, 18 terpenes, 4 alcohols, 2 aldehydes and ketones, 2 phenols, 1 aromatics, 2 heterocyclic.Samples were smelled of wood and earth; 64 aroma compounds were extracted out of the anaerobic ginseng, including 22 alkanes, 21 terpenes, 9 alcohols, 4 aldehydes and ketones, 3 aromatics, 2
Kazumi Hirano
Full Text Available Maintenance of self-renewal and pluripotency in mouse embryonic stem cells (mESCs is regulated by the balance between several extrinsic signaling pathways. Recently, we demonstrated that heparan sulfate (HS chains play important roles in the maintenance and differentiation of mESCs by regulating extrinsic signaling. Sulfated HS structures are modified by various sulfotransferases during development. However, the significance of specific HS structures during development remains unclear. Here, we show that 3-O-sulfated HS structures synthesized by HS 3-O-sulfotransferases (3OSTs and recognized by the antibody HS4C3 increase during differentiation of mESCs. Furthermore, expression of Fas on the cell surface of the differentiated cells also increased. Overexpression of the HS4C3-binding epitope in mESCs induced apoptosis and spontaneous differentiation even in the presence of LIF and serum. These data showed that the HS4C3-binding epitope was required for differentiation of mESCs. Up-regulation of the HS4C3-binding epitope resulted in the recruitment of Fas from the cytoplasm to lipid rafts on the cell surface followed by activation of Fas signaling. Indeed, the HS4C3-binding epitope interacted with a region that included the heparin-binding domain (KLRRRVH of Fas. Reduced self-renewal capability in cells overexpressing 3OST resulted from the degradation of Nanog by activated caspase-3, which is downstream of Fas signaling, and was rescued by the inhibition of Fas signaling. We also found that knockdown of 3OST and inhibition of Fas signaling reduced the potential for differentiation into the three germ layers during embryoid body formation. This is the first demonstration that activation of Fas signaling is mediated by an increase in the HS4C3-binding epitope and indicates a novel signaling pathway for differentiation in mESCs.
Romain Desprat
Full Text Available Insertional mutagenesis has emerged as a major obstacle for gene therapy based on vectors that integrate randomly in the genome. Reducing the genotoxicity of genomic viral integration can, in first approximation, be equated with reducing the risk of oncogene activation, at least in the case of therapeutic payloads that have no known oncogenic potential, such as the globin genes. An attractive solution to the problem of oncogene activation is the inclusion of insulators/enhancer-blockers in the viral vectors. In this study we have used Recombinase-Mediated Cassette Exchange to characterize the effect of integration of globin therapeutic cassettes in the presence or absence of the chicken HS4 and three other putative insulators inserted near Stil, Tal1 and MAP17, three well-known cellular proto-oncogenes in the SCL/Tal1 locus. We show that insertion of a Locus Control Region-driven globin therapeutic globin transgene had a dramatic activating effect on Tal1 and Map17, the two closest genes, a minor effect on Stil, and no effect on Cyp4x1, a non-expressed gene. Of the four element tested, cHS4 was the only one that was able to suppress this transgene-mediated insertional transcriptional activation. cHS4 had a strong suppressive effect on the activation expression of Map17 but has little or no effect on expression of Tal1. The suppressive activity of cHS4 is therefore promoter specific. Importantly, the observed suppressive effect of cHS4 on Map17 activation did not depend on its intercalation between the LCR and the Map 17 promoter. Rather, presence of one or two copies of cHS4 anywhere within the transgene was sufficient to almost completely block the activation of Map17. Therefore, at this complex locus, suppression of transgene-mediated insertional transcriptional activation by cHS4 could not be adequately explained by models that predict that cHS4 can only suppress expression through an enhancer-blocking activity that requires intercalation
Effect of Tanreqing injection on mycoplasma pneumonia in patients of hs-CRP, PCT, T cell subsets
Mei Bai
2016-01-01
Objective: To explore the effect of Tanreqing injection for treatment and its clinical significance through the changes of mycoplasma pneumonia patients with hs-CRP, PCT levels and cellular immune index. Method:A total of 114 cases of mycoplasma pneumonia, which were randomly divided into routine antibiotic treatment group (n=53) (control group), Tanreqing injection treatment group (n=61) (treatment group), to observe the two groups' hs-CRP and PCT levels in serum and the cellular immune regulation after treatment in patients, and contrast the curative effect. Results:the two groups before treatment, hs-CRP and PCT levels in serum had no significant difference;the treatment group after treatment, hs-CRP and PCT levels in serum were significantly lower than before treatment, and lower than that of the control group's;the control group after treatment of serum hs-CRP was significantly lower than that before treatment, compared to the before treatment, the level of PCT decreased slightly, but compared with before treatment there was no significant difference;after treatment, CD3+, CD4+, CD4+/CD8+, CD56+value were significantly higher than the control group's;CD8+and CD4+CD25+were significantly lower than the control group's;effective treatment group was significantly higher than the control group. The average hospitalization time was less than the control group's. Conclusion:Tanreqing injection adjuvant therapy could improve the treatment effect in mycoplasma pneumonia patients, regulate immune function, which was worth popularizing in clinical use.
Zhang, Ying-Xin; Hu, Kang-Di; Lv, Kai; Li, Yan-Hong; Hu, Lan-Ying; Zhang, Xi-Qi; Ruan, Long; Liu, Yong-Sheng; Zhang, Hua
2015-01-01
H2S is a signaling molecule in plants and animals. Here we investigated the effects of H2S on programmed cell death (PCD) in barley (Hordeum vulgare L.) aleurone layers. The H2S donor NaHS significantly delayed PCD in aleurone layers isolated from imbibed embryoless barley grain. NaHS at 0.25 mM effectively reduced the accumulation of superoxide anion (·O2 (-)), hydrogen peroxide (H2O2), and malondialdehyde (MDA), promoted the activity of superoxide dismutase (SOD), guaiacol peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX), and decreased those of lipoxygenase (LOX) in isolated aleurone layers. Quantitative-PCR showed that NaHS treatment of aleurone tissue led to enhanced transcript levels of the antioxidant genes HvSOD1, HvAPX, HvCAT1, and HvCAT2 and repressed transcript levels of HvLOX (lipoxygenase gene) and of two cysteine protease genes HvEPA and HvCP3-31. NaHS treatment in gibberellic acid- (GA-) treated aleurone layers also delayed the PCD process, reduced the content of ·O2 (-), and increased POD activity while decreasing LOX activity. Furthermore, α-amylase secretion in barley aleurone layers was enhanced by NaHS treatment regardless of the presence or absence of GA. These data imply that H2S acted as an antioxidant in delaying PCD and enhances α-amylase secretion regardless of the presence of GA in barley aleurone layers.
Ying-Xin Zhang
2015-01-01
Full Text Available H2S is a signaling molecule in plants and animals. Here we investigated the effects of H2S on programmed cell death (PCD in barley (Hordeum vulgare L. aleurone layers. The H2S donor NaHS significantly delayed PCD in aleurone layers isolated from imbibed embryoless barley grain. NaHS at 0.25 mM effectively reduced the accumulation of superoxide anion (·O2-, hydrogen peroxide (H2O2, and malondialdehyde (MDA, promoted the activity of superoxide dismutase (SOD, guaiacol peroxidase (POD, catalase (CAT, and ascorbate peroxidase (APX, and decreased those of lipoxygenase (LOX in isolated aleurone layers. Quantitative-PCR showed that NaHS treatment of aleurone tissue led to enhanced transcript levels of the antioxidant genes HvSOD1, HvAPX, HvCAT1, and HvCAT2 and repressed transcript levels of HvLOX (lipoxygenase gene and of two cysteine protease genes HvEPA and HvCP3-31. NaHS treatment in gibberellic acid- (GA- treated aleurone layers also delayed the PCD process, reduced the content of ·O2-, and increased POD activity while decreasing LOX activity. Furthermore, α-amylase secretion in barley aleurone layers was enhanced by NaHS treatment regardless of the presence or absence of GA. These data imply that H2S acted as an antioxidant in delaying PCD and enhances α-amylase secretion regardless of the presence of GA in barley aleurone layers.
赵有翼; 田东霞
2012-01-01
Objective To study the significance of urinary albumin excretion rate(UAER) and high sensitivity C-reactive protein (hs-CRP) in patients with unstable angina pectoris. Methods All 178 patients with unstable angina pectoris were divided into four groups. Initial onset angina pectoris group consisted of 46 patients, progressive angina pectoris group consisted of SO patients,spontaneous angina group consisted of 54 patients,and post-infarction angina pectoris group consisted of 28 patients. The level of UAER and hs-CRP were tested and the data were compared to that of 40 healthy controls. Results The levels of UAER and hs-CRP were higher both in initial onset angina pectoris group and progressive angina pectoris group than those of health con-trols(P <0.01). The UAER in post-infarction angina pectoris group was higher either( P < 0.05). Conclusion The level of UAER and hs-CRP in early periods of patients with unstable angina pectoris should be tested so as to get the best curing effect. Combining with myocardial zymogram and electrocardiogram examination,the proper therapy can prevent myocardial infarction.%目的 探讨尿微量白蛋白排泄率(UAER)与超敏C-反应蛋白(hs-CRP)在不稳定型心绞痛诊断中的临床意义.方法 将178例临床诊断为不稳定型心绞痛患者分为初发劳力型心绞痛组46例,恶化劳力型心绞痛组50例,自发型心绞痛组54例及梗死后心绞痛组28例；同期正常体检者40例作为对照组,分别应用免疫金标法测定尿微量白蛋白排泄率,免疫比浊法测定超敏C-反应蛋白水平,并进行比较.结果 初发型心绞痛组和恶化型心绞痛组的UAER及hs-CRP均有很大程度的增高,二者显著高于对照组(P＜0.01)；梗死后心绞痛组UAER明显高于对照组(P＜0.05),hs-CRP在正常范围；自发型心绞痛组两项测定指标均在正常范围.结论 在心绞痛的早期应该注意监测UAER和hs-CRP的变化,以其尽早干预心绞痛的病程进展,对于
Allelic Imbalance of mRNA Associated with α2-HS Glycoprotein (Fetuin-A Polymorphism
Yoshihiko Inaoka
2015-01-01
Full Text Available Alpha 2-HS glycoprotein (AHSG, also designated as fetuin-A, exhibits polymorphism in population genetics consisting of two major alleles of AHSG∗1 and AHSG∗2. The serum level in the AHSG∗1 homozygote is significantly higher than that of the AHSG∗2 homozygote. This study examined the molecular mechanism for the cis-regulatory expression. To quantitate allele-specific mRNA in intra-assays of the heterozygote, RT-PCR method employing primers that were incorporated to the two closely located SNPs was developed. The respective magnitudes of AHSG∗1 to AHSG∗2 in the liver tissues and hepatic culture cells of PLC/PRF/5 were determined quantitatively as 2.5-fold and 6.2-fold. The mRNA expressional difference of two major alleles was observed, which is consistent with that in the serum level. The culture cells carried heterozygous genotypes in rs4917 and rs4918, but homozygous one in rs2248690. It was unlikely that the imbalance was derived from the SNP located in the promotor site. Furthermore, to investigate the effect of mRNA degradation, RNA synthesis in the cell culture was inhibited potently by the addition of actinomycin-D. No marked change was apparent between the two alleles. The results indicated that the cis-regulatory expressional difference is expected to occur at the level of transcription or splicing of mRNA.
Allelic Imbalance of mRNA Associated with α2-HS Glycoprotein (Fetuin-A) Polymorphism.
Inaoka, Yoshihiko; Osawa, Motoki; Mukasa, Nahoko; Miyashita, Keiko; Satoh, Fumiko; Kakimoto, Yu
2015-01-01
Alpha 2-HS glycoprotein (AHSG), also designated as fetuin-A, exhibits polymorphism in population genetics consisting of two major alleles of AHSG(∗) 1 and AHSG(∗) 2. The serum level in the AHSG(∗) 1 homozygote is significantly higher than that of the AHSG(∗) 2 homozygote. This study examined the molecular mechanism for the cis-regulatory expression. To quantitate allele-specific mRNA in intra-assays of the heterozygote, RT-PCR method employing primers that were incorporated to the two closely located SNPs was developed. The respective magnitudes of AHSG(∗) 1 to AHSG(∗) 2 in the liver tissues and hepatic culture cells of PLC/PRF/5 were determined quantitatively as 2.5-fold and 6.2-fold. The mRNA expressional difference of two major alleles was observed, which is consistent with that in the serum level. The culture cells carried heterozygous genotypes in rs4917 and rs4918, but homozygous one in rs2248690. It was unlikely that the imbalance was derived from the SNP located in the promotor site. Furthermore, to investigate the effect of mRNA degradation, RNA synthesis in the cell culture was inhibited potently by the addition of actinomycin-D. No marked change was apparent between the two alleles. The results indicated that the cis-regulatory expressional difference is expected to occur at the level of transcription or splicing of mRNA.
Determination of benzene in different food matrices by distillation and isotope dilution HS-GC/MS
Medeiros Vinci, Raquel [Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent (Belgium); Canfyn, Michael [Food, Medicines and Consumer Safety, Scientific Institute of Public Health, Rue Juliette Wytsmanstraat 14, 1050 Brussels (Belgium); De Meulenaer, Bruno [Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent (Belgium); Schaetzen, Thibault de; Van Overmeire, Ilse; De Beer, Jacques [Food, Medicines and Consumer Safety, Scientific Institute of Public Health, Rue Juliette Wytsmanstraat 14, 1050 Brussels (Belgium); Van Loco, Joris, E-mail: Joris.VanLoco@iph.fgov.BE [Food, Medicines and Consumer Safety, Scientific Institute of Public Health, Rue Juliette Wytsmanstraat 14, 1050 Brussels (Belgium)
2010-07-05
Benzene is classified by the IARC as carcinogenic to humans. Several sources may contribute for the occurrence of benzene in foods, such as, environmental contamination and the reaction of benzoate salts with ascorbic acid (naturally present or added as food additives). Matrix effect on benzene recovery (e.g. in fatty foods) and artefactual benzene formation from benzoate during analysis in the presence of ascorbate are some of the challenges presented when determining benzene in a wide range of foodstuffs. Design of experiment (DOE) was used to determine the most important variables in benzene recovery from headspace GC/MS. Based on the results of the DOE, a versatile method for the extraction of benzene from all kind of food commodities was developed. The method which consisted of distillation and isotope dilution HS-GC/MS was in-house validated. Artefactual benzene was prevented by addition of a borate buffer solution (pH 11) under distillation conditions. The method presented in this study allows the use of a matrix-independent calibration with detection limits below the legal limit established by the European Council for benzene in drinking water (1 {mu}g L{sup -1}).
Determination of benzene in different food matrices by distillation and isotope dilution HS-GC/MS.
Vinci, Raquel Medeiros; Canfyn, Michael; De Meulenaer, Bruno; de Schaetzen, Thibault; Van Overmeire, Ilse; De Beer, Jacques; Van Loco, Joris
2010-07-01
Benzene is classified by the IARC as carcinogenic to humans. Several sources may contribute for the occurrence of benzene in foods, such as, environmental contamination and the reaction of benzoate salts with ascorbic acid (naturally present or added as food additives). Matrix effect on benzene recovery (e.g. in fatty foods) and artefactual benzene formation from benzoate during analysis in the presence of ascorbate are some of the challenges presented when determining benzene in a wide range of foodstuffs. Design of experiment (DOE) was used to determine the most important variables in benzene recovery from headspace GC/MS. Based on the results of the DOE, a versatile method for the extraction of benzene from all kind of food commodities was developed. The method which consisted of distillation and isotope dilution HS-GC/MS was in-house validated. Artefactual benzene was prevented by addition of a borate buffer solution (pH 11) under distillation conditions. The method presented in this study allows the use of a matrix-independent calibration with detection limits below the legal limit established by the European Council for benzene in drinking water (1 microg L(-1)).
Integrated HS and ALS Remote Sensing Data Sources to Develop Green Corridors in Sopron Mountains
János Tamás
2015-01-01
Full Text Available The green corridors are part of the European Union rural landscapes, but the regional increase in size of agricultural parcels had a significant effect on European land use in the 20th century. This effect radically reduced the coverage of natural forest. One ecological problem with the remaining forests is the partial missing of the network connecting the parts with ecological green corridors. Another economical problem is the verifiability for the payment system of agroforestry. Remote sensing methods are currently used to supervise monitoring the arable lands, plantations, natural reserve areas, as well as to help for the European Union payment system. Nowadays the airborne hyperspectral (HS and LiDAR (Light Detection And Ranging; ALS remote sensing technologies are becoming of more widespread use. They can be applied especially in spatial decision support system (SDSS, used in decisions about for nature, environment, forests, agriculture protection, conservation and monitoring, as well as for monitoring of biomass production. Our site selection model was the first step towards planning an agroforestry plantation which uses these integrated technologies to connect the parts with green corridors.
Subaru high resolution spectroscopy of complex metal absorption lines of QSO HS1603+3820
Misawa, T; Takada-Hidai, M; Wang, Y; Kashikawa, N; Iye, M; Tanaka, I; Misawa, Toru; Yamada, Toru; Takada-Hidai, Masahide; Wang, Yiping; Kashikawa, Nobunari; Iye, Masanori; Tanaka, Ichi
2002-01-01
We present a high resolution spectrum of the quasar, HS1603+3820 (z_em=2.542), observed with the High Dispersion Spectrograph (HDS) on Subaru Telescope. This quasar, first discovered in the Hamburg/CfA Quasar Survey, has 11 C IV lines at 1.96 2.29 and resolves some of them into multiple narrow components with b 65 km/s). We use three properties of C IV lines, specifically, time variability, covering factor, and absorption line profile, to classify them into quasar intrinsic absorption lines (QIALs) and spatially intervening absorption lines (SIALs). The C IV lines at 2.42 < z_abs < 2.45 are classified as QIALs in spite of their large velocity shifts from the quasar. Perhaps they are produced by gas clouds ejected from the quasar with the velocity of v_ej = 8000 km/s -- 10000 km/s. On the other hand, three C IV lines at 2.48 < z_abs < 2.55 are classified as SIALs, which suggests there exist intervening absorbers near the quasar. We, however, cannot rule out QIALs for the two lines at z_abs ~ 2.54...
Time-Variable Complex Metal Absorption Lines in the Quasar HS1603+3820
Misawa, T; Charlton, J C; Tajitsu, A; Misawa, Toru; Eracleous, Michael; Charlton, Jane C.; Tajitsu, Akito
2005-01-01
We present a new spectrum of the quasar HS1603+3820 taken 1.28 years (0.36 years in the quasar rest frame) after a previous observation with Subaru+HDS. The new spectrum enables us to search for time variability as an identifier of intrinsic narrow absorption lines (NALs). This quasar shows a rich complex of C IV NALs within 60,000 km/s of the emission redshift. Based on covering factor analysis, Misawa et al. found that the C IV NAL system at z_abs= 2.42--2.45 (System A, at a shift velocity of v_sh = 8,300--10,600 km/s relative to the quasar) was intrinsic to the quasar. With our new spectrum, we perform time variability analysis as well as covering factor analysis to separate intrinsic NALs from intervening NALs for 8 C IV systems. Only System A, which was identified as an intrinsic system in the earlier paper by Misawa et al., shows a strong variation in line strength (W_obs ~ 10.4A -> 19.1A). We speculate that a broad absorption line (BAL) could be forming in this quasar. We illustrate the plausibility of...
Study on the Aromatic Components of Green Plum Wine by HS-SPME-GC-MS
Yingying MA; Hechuan WU; Qingbin LIU; Lingyun WANG; Xiao DOU; Lin YANG; Jiangang YANG
2016-01-01
In order to better blend green plum wine and study aromatic components of green plum wine,a qualitative analysis on aromatic components of soaked base liquor,green plum soaked wine,green plum juice,and fermented wine of green plum juice by Head Space Solid-phase Microextraction( HS-SPME) and Gas Chromatograph Mass Spectrometer( GC-MS) was studied in this paper. Experiment results indicated that14,32,17,and 46 kinds of aromatic components were identified respectively from four samples. Different aromatic components determined the special flavor and taste of green plum wine. Unique aromatic components generated in soaking process include benzaldehyde,1-butanol,2-methyl-,S-(-),benzoic acid ethyl ester,and 5-( hydroxymethyl). Special aromatic components in green plum juice were furfural,phenylethyl alcohol,and benzyl alcohol. The aromatic components in fermented wine of green plum juice mainly included phenylethyl alcohol( 6. 941%,relative content of peak area,same below),1-butanol,3-methyl-( 6. 940%),octanoic acid,ethyl ester( 3. 734%),decanoic acid,ethyl ester( 2. 590%),hexanoic acid,ethyl ester( 2. 479%),ethyl 9-decenoate( 2. 080%),and 5-hydroxymethyl( 1. 756%). This study was expected to provide scientific basis and data reference for quality improvement of green plum wine.
Gharibzahedi, Seyed Mohammad Taghi; Razavi, Seyed Hadi; Mousavi, Seyed Mohammad
2012-11-01
An acceptable strategy to incorporate canthaxanthin (CX) as a natural colorant into products is by means of oil-in-water emulsions. The used CX in this study was produced by bacterium Dietzia natronolimnaea HS-1 using a batch bioreactor system. A central composite rotatable design-response surface methodology (CCRD-RSM) consisting of three-factored factorial design with five levels was applied for analysis of the results to obtain the optimal formulation of emulsions. Three independent variables including fenugreek gum (FG, 0.2-0.5%, w/w), coconut oil (CO, 6-10%, w/w), and CO/CX ratio (10:1-50:1) were transformed to coded values and second-order polynomial models was developed to predict the responses (pproperties such as volume-weighted mean diameter (D₄₃), specific surface area (S(v)) and polydispersity index (PDI) of emulsions. The 3-D response surface plot derived from the mathematical models was used to determine the optimal conditions. Main emulsion components under the optimum conditions ascertained presently by RSM: 50:1 CO/CX ratio, 0.49% (w/w) FG content and 6.28% (w/w) CO concentration. At this optimum point, stability, viscosity, D₄₃, S(v) and PDI were 90.6%, 0.0118 Pas, 0.595 μm, 12.03 m²/ml and 1.380, respectively.
Canthaxanthin biosynthesis by Dietzia natronolimnaea HS-1: effects of inoculation and aeration rate
Forouzan Rostami
2014-06-01
Full Text Available The interest in production of natural colorants by microbial fermentation has been currently increased. The effects of D-glucose concentration (3.18-36.82 g/L, inoculum size (12.5 x 10(9-49.5 x 10(9 cfu cells/mL and air-flow rate (1.95-12.05 L/L min on the biomass, total carotenoid and canthaxanthin (CTX accumulation of Dietzia natronolimnaea HS-1 in a batch bioreactor was scrutinized using a response surface methodology-central composite rotatable design (RSM-CCRD. Second-order polynomial models with high R² values ranging from 0.978 to 0.990 were developed for the studied responses using multiple linear regression analysis. The models showed the maximum cumulative amounts of biomass (7.85 g/L, total carotenoid (5.48 mg/L and CTX (4.99 mg/L could be achieved at 23.38 g/L of D-glucose, 31.2 x 10(9 cfu cells/mL of inoculation intensity and air-flow rate of 7.85 L/L min. The predicted values for optimum conditions were in good agreement with experimental data.
The orbital and superhump periods of the dwarf nova HS 0417+7445 in Camelopardalis
Shears, J H; Brady, S; Dubovsky, P; Miller, I; Staels, B
2010-01-01
We present the 2005-2010 outburst history of the SUUMa-type dwarf HS 0417+7445,along with a detailed analysis of extensive time-series photometry obtained in March 2008 during the second recorded superoutburst of the system. The mean outburst interval is 197 \\pm 59 d, with a median of 193 d. The March 2008 superoutburst was preceeded by a precursor outburst, had an amplitude of 4.2 magnitudes, and the whole event lasted about 16 days. No superhumps were detected during the decline from the precursor outburst, and our data suggests instead that orbital humps were present during that phase. Early superhumps detected during the rise to the superoutburst maximum exhibited an unusually large fractional period excess of epsilon = 0.137 (Psh = 0.0856(88) d). Following the maximum, a linear decline in brightness followed, lasting at least 6 days. During this decline, a stable superhump period of Psh = 0.07824(2) d was measured. Superimposed on the superhumps were orbital humps, which allowed us to accurately measure ...
Production and decay of element 114: high cross sections and the new nucleus 277Hs
Dullmann, Ch.E.; Schadel, M.; Yakushev, A.; Turler, A.; Eberhardt, K.; Kratz, J.V.; Ackermann, D.; Andersson, L.-L.; Block, M.; Bruchle, W.; Dvorak, J.; Essel, H.G.; Ellison, P.A.; Even, J.; Gates, J.M.; Gorshkov, A.; Graeger, R.; Gregorich, K.E.; Hartmann, W.; Herzberg, R.-D.; Hessberger, F.P.; Hild, D.; Hubner, A.; Jager, E.; Khuyagbaatar, J.; Kindler, B.; Krier, J.; Kurz, N.; Lahiri, S.; Liebe, D.; Lommel, B.; Maiti, M.; Nitsche, H.; Omtvedt, J.P.; Parr, E.; Rudolph, D.; Runke, J.; Schausten, B.; Schimpf, E.; Semchenkov, A.; Steiner, J.; Thorle-Pospiech, P.; Uusitalo, J.; Wegrzecki, M.; Wiehl, N.
2009-12-22
The fusion-evaporation reaction {sup 244}Pu({sup 48}Ca,3-4n){sup 288,289}114 was studied at the new gas-filled recoil separator TASCA. Thirteen correlated decay chains were observed and assigned to the production and decay of {sup 288,289}114. At a compound nucleus excitation energy of E* = 39.8-43.9 MeV, the 4n evaporation channel cross section was 9.8{sub -3.1}{sup +3.9} pb. At E* = 36.1-39.5 MeV, that of the 3n evaporation channel was 8.0{sub -4.5}{sup +7.4} pb. In one of the 3n evaporation channel decay chains, a previously unobserved {alpha} branch in {sup 281}Ds was observed (probability to be of random origin from background: 0.1%). This {alpha} decay populated the new nucleus {sup 277}Hs, which decayed by spontaneous fission after a lifetime of 4.5 ms.
Analysis of Five Earthy-Musty Odorants in Environmental Water by HS-SPME/GC-MS
Zhen Ding
2014-01-01
Full Text Available The pressing issue of earthy and musty odor compounds in natural waters, which can affect the organoleptic properties of drinking water, makes it a public health concern. A simple and sensitive method for simultaneous analysis of five odorants in environmental water was developed by headspace solid-phase microextraction (HS-SPME coupled to chromatography-mass spectrometry (GC-MS, including geosmin (GSM and 2-methylisoborneol (2-MIB, as well as dimethyl trisulfide (DMTS, β-cyclocitral, and β-ionone. Based on the simple modification of original magnetic stirrer purchased from CORNING (USA, the five target compounds can be separated within 23 min, and the calibration curves show good linearity with a correlation coefficient above 0.999 (levels = 5. The limits of detection (LOD are all below 1.3 ng L−1, and the relative standard deviation (%RSD is between 4.4% and 9.9% (n = 7 and recoveries of the analytes from water samples are between 86.2% and 112.3%. In addition, the storage time experiment indicated that the concentrations did not change significantly for GSM and 2-MIB if they were stored in canonical environment. In conclusion, the method in this study could be applied for monitoring these five odorants in natural waters.
Hojjati, Mohammad; Razavi, Seyed Hadi; Rezaei, Karamatollah; Gilani, Kambiz
2014-09-01
The strain bacterium Dietzia natronolimnaea has propounded as a source for biological production of canthaxanthin. Because of sensitivity of this pigment, examine on its stability is important. In this study, stability of encapsulated canthaxanthin from D. natronolimnaea HS-1 using soluble soybean polysaccharide (SSPS), gum acacia (GA), and maltodextrin (MD) as wall materials was investigated at 4, 25, and 45 °C in light and dark conditions during 4 months of storage. It was shown that the type of walls influenced the size of emulsion droplets; spray dried particles, microencapsulation efficiency (ME), and retention of canthaxanthin in microcapsules. SSPS and MD produced the smallest and the biggest emulsion droplets and spray dried particles, respectively. Microcapsules made with SSPS resulted in better ME and higher stability for canthaxanthin. Samples were degraded in all conditions, especially in light and 45 °C. Degradation of microencapsulated canthaxanthin with SSPS and GA proceeded more slowly than did with MD. Regardless of the type of wall materials, total canthaxanthin contents of the microencapsulated products decreased by an increase in time or temperature. Also, samples exposed to light indicated less stability at 4 and 25 °C when compared to the storage at dark conditions. According to the results of this study, SSPS can be considered as potential wall material for the encapsulation of carotenoids.
Definition of the switch surface in the solution structure of Cdc42Hs.
Feltham, J L; Dötsch, V; Raza, S; Manor, D; Cerione, R A; Sutcliffe, M J; Wagner, G; Oswald, R E
1997-07-22
Proteins of the rho subfamily of ras GTPases have been shown to be crucial components of pathways leading to cell growth and the establishment of cell polarity and mobility. Presented here is the solution structure of one such protein, Cdc42Hs, which provides insight into the structural basis for specificity of interactions between this protein and its effector and regulatory proteins. Standard heteronuclear NMR methods were used to assign the protein, and approximately 2100 distance and dihedral angle constraints were used to calculate a set of 20 structures using a combination of distance geometry and simulated annealing refinement. These structures show overall similarity to those of other GTP-binding proteins, with some exceptions. The regions corresponding to switch I and switch II in H-ras are disordered, and no evidence was found for an alpha-helix in switch II. The 13-residue insertion, which is only present in rho-subtype proteins and has been shown to be an important mediator of binding of regulatory and target proteins, forms a compact structure containing a short helix lying adjacent to the beta4-alpha3 loop. The insert forms one edge of a "switch surface" and, unexpectedly, does not change conformation upon activation of the protein by the exchange of GTP analogs for GDP. These studies indicate the insert region forms a stable invariant "footrest" for docking of regulatory and effector proteins.
Wang, L; Chang, S; Guan, J; Shangguan, S; Lu, X; Wang, Z; Wu, L; Zou, J; Zhao, H; Bao, Y; Qiu, Z; Niu, B; Zhang, T
2015-01-01
Epigenetic regulation of long interspersed nucleotide element-1 (LINE-1) retrotransposition events plays crucial roles during early development. Previously we showed that LINE-1 hypomethylation in neuronal tissues is associated with pathogenesis of neural tube defect (NTD). Herein, we further evaluated LINE-1 Homo sapiens (L1Hs) methylation in tissues derived from three germ layers of stillborn NTD fetuses, to define patterns of tissue specific methylation and site-specific hypomethylation at CpG sites within an L1Hs promoter region. Stable, tissue-specific L1Hs methylation patterns throughout three germ layer lineages of the fetus, placenta, and maternal peripheral blood were observed. Samples from maternal peripheral blood exhibited the highest level of L1Hs methylation (64.95%) and that from placenta showed the lowest (26.82%). Between samples from NTDs and controls, decrease in L1Hs methylation was only significant in NTD-affected brain tissue at 7.35%, especially in females (8.98%). L1Hs hypomethylation in NTDs was also associated with a significant increase in expression level of an L1Hs-encoded transcript in females (r = -0.846, p = 0.004). This could be due to genomic DNA instability and alternation in chromatins accessibility resulted from abnormal L1Hs hypomethylation, as showed in this study with HCT-15 cells treated with methylation inhibitor 5-Aza.
Xiong, J.; Koopal, L.K.; Weng, L.; Wang, J.; Tan, W.
2015-01-01
The effects of soil fulvic (JGFA) and humic acid (JGHA) on Pb binding to goethite were investigated with batch experiments and modeling. The CD-MUSIC and NICA-Donnan model could describe the Pb binding to, respectively, the binary Pb–goethite and Pb–HS systems. The adsorption of humic substances (HS
陈干明; 王晴; 张欣中
2012-01-01
目的 探讨糖尿病并发急性脑梗死患者血清hs-CRP水平与病情及预后的关系.方法 测定88例糖尿病并发急性脑梗死患者血清hs-CRP含量,分析与病情及预后关系.结果 糖尿病并发急性脑梗死患者血清hs-CRP水平明显高于糖尿病并发脑腔隙性脑梗死患者(P<0.01);脑梗死重型组血清hs-CRP水平高于中型、轻型组(P<0.05);随防1年,血清hs-CRP水平高者易复发.结论 糖尿病并发急性脑梗死患者血清hs-CRP水平升高,提示患者病情重、预后差、易复发.早期测定血清hs-CRP水平有助于评估糖尿病并发急性脑梗死的病情及预后.%Objective To the correlation of the serum hs - CRP level, the clinical situation and the prognosis of the patient with diabetes complicated with acute cerebral infarction. Methods 88 patients with diabetes complicated with acute cerebral infarction were measure of their serum hs - CRP level, the correlation to the clinical situation and prognosis was ananlyzed. Results The serum hs - CRP level of the patient with diabetes complicated with acute cerebral infarction was significantly higher than that of the patient with diabetes complicated with cerebral lacunar infarction ( P < 0. 01) , the serum hs - CRP level was higher in the severe infarction than in the medium and mild group ( P < 0. 05) , the patients were followed up for one year and those with high level of serum hs - CRP was more easy for relatpsing. Conclusions The serum hs - CRP level in the patient with diabetes complicated with acute cerebral infarction is elevated, which indicates a more severe clinical situation and poor prognosis. The early measurement of serum hs - CRP helps for the evaluation of diabetes complicated with acute cerebral infarction and its prognosis.
Niyi-Odumosu, F A; Bello, O A; Biliaminu, S A; Owoyele, B V; Abu, T O; Dominic, O L
2017-03-06
There is an inverse relationship between regular physical activity and concentration of serum inflammatory markers, with variations in resting CRP in trained and untrained subjects. The effect of acute and prolonged exercises has been studied on inflammatory markers with dearth of information and controversies on the resting serum values of high sensitivity CRP (hs-CRP). Therefore, this study sought to identify and compare variations that occur in serum levels of high sensitivity CRP in groups of sportsmen (6) and physically active untrained subjects. Eighty-one healthy male participants made up of 21 untrained (control), 10 footballers, 10 athletes, 10 karates, 10 volleyballers, 10 basketballers, and 10 baseballers voluntarily participated in the study. Participants rested while in sitting position for about 30 minutes during which blood pressures and heart rates were taken. 5 mls of venous blood was withdrawn from the antecubital vein of the participants (aseptically) between 7:00 and 10:00 am into lithium heparin bottles following an overnight fast. The supernatant was decanted and centrifuged at 3000 rpm, serum was collected and stored at -20ºC prior to biochemical assay which was done with the use of enzyme linked immunosorbent assay (ELISA) kits for hs-CRP. Differences in the means within the sporting groups were analysed using one-way ANOVA while the difference between the trained sportsmen and untrained young adults was analysed using the independent T-test. Statistical significance was set at p hs-CRP (µg/ml) was 1.0±0.2 in the untrained, 2.6±0.7 in footballers, 3.6±2.1 in track athletes, 2.4±0.5 in basketballers, 2.2±0.5 in volleyballers, 2.4±1.3 in baseballers, and 1.7±0.5 in karate respectively. There was no significant difference in the resting hs-CRP amongst the sporting groups, and in the sportsmen and untrained group. Resting serum levels of hs-CRP falls within normal range, and varies insignificantly in groups of sports, and in sportsmen
Aleksandrova, Olga
2017-04-01
Humic substances represent the major reservoir of carbon (C) in ecosystems, and their turnover is crucial for understanding the global C cycle. As shown by some investigators [1-2], the phenomenon of the uptake of the whole humic particles by plant roots is a significant step of biogeochemical cycle of carbon in soils. The mechanism of HS entry the root interior remained unknown for a long time. However recently, the last one was discovered [3]. An advanced model [3] includes two hypotheses. These hypotheses are as follows: (1) each nano-size particle possesses a quantum image that can be revealed as a packet of electromagnetic waves; (2) the interaction of nano-size particle with the membrane (plasma membrane) of living cells, on which it is adsorbed, occurs via the development of the Rayleigh-Taylor (RT) instability on the membrane surface. An advanced model allows us to look insight some into some phenomena that were observed by experiments but remained not understood [2]. The authors [2] applied tritium autoradiography to wheat seedlings cultivated with tritium-labeled HS to consider the uptake of humic particles by plant roots. They found a significant increase in the content of some polar (monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG), sulfoquinovosyl diacylglycerol (SQDG) and phosphatidylcholine (PC)) and neutral (free fatty acids, FFA) lipids which were detected in the wheat seedlings treated with humic particles. Authors [2] pointed that lipids MGDG, DGDG, SQDG are crucial for functional and structural integrity of the photosystem complex. Therefore, a stimulating action of adsorbed humic particles evoked phenomena like photosynthesis in root cells that can be interpreted using an advanced model: humic particles being nano-size particles become adsorbed on the plant roots in soils, and influence their micro environment, where they are located, with the specific electromagnetic exposure. Another finding of authors consisted in the
Urban Transformation and Property Value Variation. The Role of HS Stations
Carmela Gargiulo
2010-04-01
operation, partly in operation or not yet in operation. Besides, the description of each case is divided into: summary description of the characteristics of the HS railway line; description of the main features of cities that represent the nodes of the selected routes; identify the characteristics of the surrounding context of the railway station; measurement of the change in property values in the surrounding context of the railway station due to HS link. The third part provides a comparative outline of the effects of High Speed stations on property values and the urban typologies and characteristics that influence this relation. The first result of this article is a comparative framework between all study cases. In conclusion, the comparative reading shows that the effect from opening of the High Speed railway stations on property values is valuable in cases where it contributes significantly to raising the socio-economic and the quality conditions of spaces.
Theses\\' subjects chosen from public needs: Experience of Yazd Health Study (YaHS
AA Dehghanitaftiti
2014-12-01
Full Text Available Yazd Health Study (YaHS is an endeavor to involve students in design, implementation and analysis of a large study. Over 150 graduate and post graduate students from various disciplines have been invited to participate in a large longitudinal study with 10000 samples. Participants were selected randomly from Yazd population, over 1000000 as December 2014. Four hundred variables grouped in the following sections were asked 1 demographics, 2 physical activity, 3sleep quality and quantity, 4 mental health, 5 history y of chronic illnesses, 6 history of surgical operations, 7 dental health, 8 history of accidents, 9 dietetic habits, 10 occupation and communication history, 11 traditional medicine, 12 history of smoking and addiction and 13 women’s health. The interview follows by anthropometric measurements including weight, height, BMI, waist circumference, hip circumference, neck circumference and WHR. Per cent body fat, % body muscle, visceral fat, resting metabolism have been measured followed by pulse and blood pressure. Students were trained to participate in design, piloting and the main phase of data collection. Students evaluated the experience useful and constructive. In return of their collaboration in interviewing 50-100 study participants, they will receive data for their theses' proposal. This will help them to access a large and high quality set of data and disseminate the results in high quality peer reviewed journals as well as national and international conferences. The students mandated to write an executive summary of their thesis and disseminate it to health managers and inter-sectoral decision makers. They will gain bonus score if they can publish their main findings in public media. Acknowledgments: Thanks to students who participated in the study and A. Professor Masoud Mirzaei, the principal investigator of Yazd Health Study (YAHS for providing information on the design and the progress of the study.
Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts
Yoon, Jong Hyuk; Kim, Jaeyoon; Lee, Hyeongjoo [NovaCell Technology Inc., Pohang, Kyungbuk 790-784 (Korea, Republic of); Kim, So Young [Department of Dermatology, Chung-Ang University College of Medicine, Seoul 156-756 (Korea, Republic of); Department of Convergence Medicine and Pharmaceutical Biosciences, Graduate School, Chung-Ang University, Seoul 156-756 (Korea, Republic of); Jang, Hwan-Hee [Functional Food and Nutrition Division, Department of Agrofood Resources, Rural Development Administration, Suwon 441-853 (Korea, Republic of); Ryu, Sung Ho [Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk 790-784 (Korea, Republic of); Kim, Beom Joon [Department of Dermatology, Chung-Ang University College of Medicine, Seoul 156-756 (Korea, Republic of); Department of Convergence Medicine and Pharmaceutical Biosciences, Graduate School, Chung-Ang University, Seoul 156-756 (Korea, Republic of); Lee, Taehoon G., E-mail: taehoon@novacelltech.com [NovaCell Technology Inc., Pohang, Kyungbuk 790-784 (Korea, Republic of)
2012-11-23
Highlights: Black-Right-Pointing-Pointer We identify a function of the YIGSR peptide to enhance collagen synthesis in Hs27. Black-Right-Pointing-Pointer YIGSR peptide enhanced collagen type 1 synthesis both of gene and protein levels. Black-Right-Pointing-Pointer There were no changes in cell proliferation and MMP-1 level in YIGSR treatment. Black-Right-Pointing-Pointer The YIGSR effect on collagen synthesis mediated activation of FAK, pyk2 and ERK. Black-Right-Pointing-Pointer The YIGSR-induced FAK and ERK activation was modulated by FAK and MEK inhibitors. -- Abstract: The dermal ECM is synthesized from fibroblasts and is primarily compromised of fibrillar collagen and elastic fibers, which support the mechanical strength and resiliency of skin, respectively. Laminin, a major glycoprotein located in the basement membrane, promotes cell adhesion, cell growth, differentiation, and migration. The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the {beta}1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. In this study, we identified a novel function of the YIGSR peptide to enhance collagen synthesis in human dermal fibroblasts. To elucidate this novel function regarding collagen synthesis, we treated human dermal fibroblasts with YIGSR peptide in both a time- and dose-dependent manner. According to subsequent experiments, we found that the YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. This YIGSR peptide-mediated collagen type 1 synthesis was modulated by FAK inhibitor and MEK inhibitor. This study clearly reveals that YIGSR peptide plays a novel function on the collagen type 1 synthesis of dermal fibroblasts and also suggests that YIGSR is a strong candidate
Quantification of Polyfunctional Thiols in Wine by HS-SPME-GC-MS Following Extractive Alkylation
Lauren E. Musumeci
2015-07-01
Full Text Available Analyses of key odorous polyfunctional volatile thiols in wines (3-mercaptohexanol (3-MH, 3-mercaptohexylacetate (3-MHA, and 4-mercapto-4-methyl-2-pentanone (4-MMP are challenging due to their high reactivity and ultra-trace concentrations, especially when using conventional gas-chromatography electron impact mass spectrometry (GC-EI-MS. We describe a method in which thiols are converted to pentafluorobenzyl (PFB derivatives by extractive alkylation and the organic layer is evaporated prior to headspace solid phase microextraction (HS-SPME and GC-EI-MS analysis. Optimal parameters were determined by response surface area modeling. The addition of NaCl solution to the dried SPME vials prior to extraction resulted in up to less than fivefold improvement in detection limits. Using 40 mL wine samples, limits of detection for 4-MMP, 3-MH, and 3-MHA were 0.9 ng/L, 1 ng/L, and 17 ng/L, respectively. Good recovery (90%–109% and precision (5%–11% RSD were achieved in wine matrices. The new method was used to survey polyfunctional thiol concentrations in 61 commercial California and New York State wines produced from V. vinifera (Riesling, Gewürztraminer, Cabernet Sauvignon, Sauvignon blanc and non-varietal rosé wines, V. labruscana (Niagara, and Vitis spp. (Cayuga White. Mean 4-MMP concentrations in New York Niagara (17 ng/L were not significantly different from concentrations in Sauvignon blanc, but were significantly higher than 4-MMP in other varietal wines.
Online breath gas analysis in unrestrained mice by hs-PTR-MS.
Szymczak, Wilfried; Rozman, Jan; Höllriegl, Vera; Kistler, Martin; Keller, Stefan; Peters, Dominika; Kneipp, Moritz; Schulz, Holger; Hoeschen, Christoph; Klingenspor, Martin; de Angelis, Martin Hrabě
2014-04-01
The phenotyping of genetic mouse models for human disorders may greatly benefit from breath gas analysis as a noninvasive tool to identify metabolic alterations in mice. Phenotyping screens such as the German Mouse Clinic demand investigations in unrestrained mice. Therefore, we adapted a breath screen in which exhaled volatile organic compounds (VOCs) were online monitored by proton transfer reaction mass spectrometry (hs-PTR-MS). The source strength of VOCs was derived from the dynamics in the accumulation profile of exhaled VOCs of a single mouse in a respirometry chamber. A careful survey of the accumulation revealed alterations in the source strength due to confounders, e.g., urine and feces. Moreover changes in the source strength of humidity were triggered by changes in locomotor behavior as mice showed a typical behavioral pattern from activity to settling down in the course of subsequent accumulation profiles. We demonstrated that metabolic changes caused by a dietary intervention, e.g., after feeding a high-fat diet (HFD) a sample of 14 male mice, still resulted in a statistically significant shift in the source strength of exhaled VOCs. Applying a normalization which was derived from the distribution of the source strength of humidity and accounted for varying locomotor behaviors improved the shift. Hence, breath gas analysis may provide a noninvasive, fast access to monitor the metabolic adaptation of a mouse to alterations in energy balance due to overfeeding or fasting and dietary macronutrient composition as well as a high potential for systemic phenotyping of mouse mutants, intervention studies, and drug testing in mice.
中度嗜盐菌HS1产纤维素酶发酵条件的研究%Study on Cellulase Production by A Moderately Halophilic Bacterium HS1
韩秋菊; 张倩倩
2011-01-01
对一株中度嗜盐菌HS1产纤维素酶的活性进行了初步研究.单因素实验和正交实验结果表明,菌株HS1产纤维素酶的最佳发酵氮源为1.5%NaNO3,优化的发酵条件为:液体种子接种量6%、培养温度35℃、初始pH值6.5、培养时间4 d.%In this paper, cellulase production by a moderately halophilic bacterium HS1 was preliminarily explored. Through single factor experiment and orthogonal experiment, it was found that the optimal nitrogen source was 1.5％ NaNO3 for production of cellulase and the optimum fermentation conditions were as follows:inoculating quantity of liquid seed of 6％ ,culture temperature of 35℃, initial pH value of 6.5 and culture time of 4 d.
Poceva Panovska, Ana; Acevska, Jelena; Stefkov, Gjoshe; Brezovska, Katerina; Petkovska, Rumenka; Dimitrovska, Aneta
2016-02-01
Within this research, a headspace (HS) gas chromatography-flame ionization detector-mass spectrometry method was developed for profiling of residual solvents (RSs) in active pharmaceutical ingredients (APIs). Design of experiment was used for optimization of sample preparation, as well as for robustness testing of the method. HS equilibration temperature and dilution medium were detected as parameters with greater impact on the sensitivity, compared with the time used for equilibration of the samples. Regardless of the sample solubility, the use of water for sample preparation was found to be crucial for better sensitivity. The use of a well-designed strategy for method development and robustness testing, additional level of identification confidence, as well as use of internal standard provided a strong and reliable analytical tool for API fingerprinting, thus enabling the authentication of the substance based on the RS profile.
On the Highest Oxidation States of Metal Elements in MO4 Molecules (M = Fe, Ru, Os, Hs, Sm, and Pu).
Huang, Wei; Xu, Wen-Hua; Schwarz, W H E; Li, Jun
2016-05-02
Metal tetraoxygen molecules (MO4, M = Fe, Ru, Os, Hs, Sm, Pu) of all metal atoms M with eight valence electrons are theoretically studied using density functional and correlated wave function approaches. The heavier d-block elements Ru, Os, Hs are confirmed to form stable tetraoxides of Td symmetry in (1)A1 electronic states with empty metal d(0) valence shell and closed-shell O(2-) ligands, while the 3d-, 4f-, and 5f-elements Fe, Sm, and Pu prefer partial occupation of their valence shells and peroxide or superoxide ligands at lower symmetry structures with various spin couplings. The different geometric and electronic structures and chemical bonding types of the six iso-stoichiometric species are explained in terms of atomic orbital energies and orbital radii. The variations found here contribute to our general understanding of the periodic trends of oxidation states across the periodic table.
Anastasia A. Batrakova
2015-11-01
Full Text Available Known, that some teleostei can perceive the geomagnetic field (GMF. However, the information about magnetosensitivity in Cyprinidae fish from artificial and natural habitats is obscure. We have registered preferred directions in Danio rerio (Hamilton from aquaria-cultivated line exposed to the natural GMF, 180 degrees reversal of horizontal GMF component, 180 degrees reversal of vertical GMF component, 180 degrees reversal of both vertical and horizontal GMF components and 90 degrees clockwise turn of horizontal GMF component. We also registered the preferred directions in Rutilus rutilus (L. from Rybinsk reservoir exposed to the natural GMF and 90 degrees clockwise turn of horizontal GMF component. It was found that zebrafish prefer two opposite directions towards east and west in the natural GMF. When the horizontal component of GMF was turned 90 degrees clockwise D. rerio prefer two opposite directions towards north and south. The possible reason of bimodality in zebrafish’s preferred directions distributions is discussed. The only direction towards east-north-east observed in roach under the natural GMF. This direction coincided with the way from the place of capture to the streamflow part of Rybinsk reservoir. And it was changed by south-south-east direction when turned the horizontal component of GMF 90 degrees clockwise. The possible reason of the choosing directions by fish with GMF is discussed.
Csiszar, Susan A; Gandhi, Nilima; Alexy, Radka; Benny, Donald T; Struger, John; Marvin, Chris; Diamond, Miriam L
2011-07-01
A model formulation based on "aquivalence", as defined in terms of activity is presented to estimate the multimedia fate of ionizing chemicals. The aquivalence approach is analogous to fugacity but aquivalence is applicable to neutral and ionizing compounds, and has been applied previously to speciating chemicals, notably metals. The new aquivalence-based mass-balance model treats ionizing organic compounds that exist as interconverting neutral and ionic species which are subject to fate processes at differing rates. The model is illustrated by application to four ionizing pharmaceuticals in Hamilton Harbour, Lake Ontario. At the system pH of 7.9-8.5, ibuprofen, gemfibrozil, and naproxen are expected to be almost entirely ionic and triclosan split between ionic and neutral forms. Measured seasonal surface water concentrations, which were 2-10 times lower in the late summer and fall than during spring, were used to solve for unknown values of chemical half-life in the water column due to degradation (photo- and bio-) of the ionizing and neutral forms and secondarily, ionic sorption coefficients of the ionizing forms. Model estimates of half-lives in the habour's water ranged from 11 to 77, 11 to 147 and 10 to 37 for ionic ibuprofen, gemfibrozil, and naproxen, respectively; and 4-22 days and 2-9 days for ionic and neutral triclosan, respectively, with the shortest half-lives in spring and the longest in summer.
Mondal, Debashri; Barat, Sudip; Mukhopadhyay, M K
2007-01-01
Static renewal bioassay tests were conducted to evaluate the acute toxicity of two neem based biopesticides, applied widely on tea plantation namely, Nimbecidine and Neem Gold either separately as well as, in combination to the fingerlings (mean body length- 4.46 +/- 0.15 cm; mean body weight- 0.49 +/- 0.15g) of a fresh water loach, Lepidocephalichthys guntea (Hamilton Buchanan) acclimatized to laboratory conditions prior to experiment. The 96 hours LC50 values for Nimbecidine and Neem Gold and the combination of the two were 0.0135 mgl(-1), 0.0525mgl(-1) and 0.0396 mgl(-1), respectively. The regular water quality analysis showed, that with increasing doses of biopesticides, dissolved oxygen level was lower and other parameters like pH, free carbon dioxide, total alkalinity total hardness, chloride ions of water increased. The fish under toxicity stress suffered several abnormalities such as erratic and rapid movement, body imbalance and surface floating responding proportionately to the increase in concentrations of the toxicant biopesticides. The 96 hours LC50 values proved Nimbecidine more toxic than Neem Gold and the combination of the two biopesticides.
Koraliya S. Todorova
2012-10-01
Full Text Available Aim: To evaluate the concurrent validity of the Hamilton Depression Rating Scale (HAMD-17 against ICD-10 criteria for depressive disorder and its performance as a screening and diagnostic tool for depression in patients with epilepsy (PWE.Subjects and Methods: One hundred and six PWE underwent clinical psychiatric examination followed by evaluation on HAMD-17. ICD-10 criteria for comorbid depressive disorder were applied. Internal consistency was assessed using Cronbach’s α. A “receiver operating characteristics” (ROC curve was obtained and the sensitivity, specificity, positive and negative predictive values (PPV, NPV were calculated for different cut-off points of the HAMD-17.Results: Internal consistency measured by Cronbach’s α was 0.74. Maximal discrimination between depressed and non depressed was obtained at a cut-off score of 8/9 (sensitivity 0.93, specificity 0.98. High sensitivity and NPV at the same cut-off score (sensitivity 0.93, NPV 1.0 show the screening properties, and high specificity and PPV at cut-offs 9/10, the diagnostic properties of the instrument. The area under the ROC curve (AUC=0.746 indicates the concurrent validity of the HAMD-17 score with the ICD-10 criteria for depressive disorder.Conclusion: The validity of the HAMD-17 against ICD-10 criteria for depressive disorder in PWE in our study is fair. The concurrent administration of diagnostic criteria can ascertain the presence of core symptoms of depression.
Dewi, Kartika; Palm, Harry W
2013-01-25
Based on light and scanning electron microscopy, two new species of philometrid nematodes, Spirophilometra endangae sp. nov. and Philometra epinepheli sp. nov. (Nematoda: Dracunculoidea: Philometridae) are described from Epinephelus coioides (Hamilton, 1822) (Perciformes: Serranidae) from the South Bali Sea, Indonesia. Spirophilometra endangae sp. nov. was isolated from the fins of E. coioides. The new species can be distinguished from the most closely related S. eichleri Parukhin, 1971 by a larger total body length and the site of infection in the host. The new species differs from S. centropomi (Caballero, 1974) also in the larger body size of the gravid females and the site of infection in the host. S. en-dangae sp. nov. differs from S. pacifica (Moravec, Santana-Pineros, Gonzales-Solis & Torres-Huerta, 2007) in the struc-ture and arrangement of the spines on the middle part of the body, the infection site of the worm, the type host and the zoogeographical host distribution. Philometra epinepheli sp. nov. differs from all other Philometra spp. congeners so far recorded from Ephinepelus groupers in the total body length and the site of infection. This is the first opercula-infecting species of Philometra described from the fish family Serranidae.
Nagoor Gani, A; Latha, S R
2016-01-01
A Hamiltonian cycle in a graph is a cycle that visits each node/vertex exactly once. A graph containing a Hamiltonian cycle is called a Hamiltonian graph. There have been several researches to find the number of Hamiltonian cycles of a Hamilton graph. As the number of vertices and edges grow, it becomes very difficult to keep track of all the different ways through which the vertices are connected. Hence, analysis of large graphs can be efficiently done with the assistance of a computer system that interprets graphs as matrices. And, of course, a good and well written algorithm will expedite the analysis even faster. The most convenient way to quickly test whether there is an edge between two vertices is to represent graphs using adjacent matrices. In this paper, a new algorithm is proposed to find fuzzy Hamiltonian cycle using adjacency matrix and the degree of the vertices of a fuzzy graph. A fuzzy graph structure is also modeled to illustrate the proposed algorithms with the selected air network of Indigo airlines.
L’«invenzione» della complementarità del pensiero federalista di Kant e Hamilton in Italia
Corrado Malandrino
2011-01-01
Full Text Available The ‘invention’ of the ‘complementarity’ of Kant’s and Hamilton’s federalist thought is the result of Mario Albertini’s philosophical elaboration. His idea of this ‘complementarity’ is bound to join together in one theoretical unit the value of the ‘perpetual peace’ among nation-states with the constitutional concept of the liberal right in the international (and particularly European frame. Albertini says this is possible, like both Kant and Hamilton demonstrated in theirs federalist essays (Zum ewigen Frieden and The Federalist, through the theory of the federal state. Therefore Kant’s and Hamilton’s political discourses are, in the opinion of Albertini and of his students, ‘complementary’ and constitute a homogeneous nucleus. Nevertheless Albertini’s theory appears as a rhetorical ‘invention’, that is a rhetorical procedure and argument to elaborate a convincing federalist ideology, not a result of scientific proceedings and discovery.