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Sample records for hallym aging study

  1. Body Composition, Sarcopenia, and Suicidal Ideation in Elderly Koreans: Hallym Aging Study.

    Science.gov (United States)

    Kim, Jeong-Hyeon; Kim, Dong-Hyun; Park, Yong Soon

    2016-04-01

    This study was conducted to assess the relationship between body composition and suicidal ideation among the Korean elderly population (n = 302; ≥ 65 years) who participated in the Hallym Aging Study in 2010. Body composition was measured using dual-energy X-ray absorptiometry, and obesity was measured by the indices of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body fat percentage. Sarcopenia was defined as presence of both low muscle mass and low muscle function. Suicidal ideation was assessed using the Beck Scale for Suicide Ideation. We found no differences in body composition measures between subjects with suicidal ideation and those without. In the logistic regression analyses, there were no significant relationships for suicidal ideation according to body composition measures, including BMI, WC, WHR, WHtR, and body fat percentage in both sexes. After adjusting for age, smoking status, alcohol drinking, regular exercise, medical comorbidities, monthly income, education level, and presence of depressive symptoms, the odds ratio (OR) of suicidal ideation was higher in elderly men with sarcopenia compared to those without, whereas no significant relationships were observed in elderly women (OR 8.28, 95% confidence interval [CI] 1.20-61.34 in men; OR 0.79, 95% CI 0.07-8.43 in women). Sarcopenia is closely associated with an increased risk of suicidal ideation in elderly men.

  2. Waist Circumference, Not Body Mass Index, Is Associated with Renal Function Decline in Korean Population: Hallym Aging Study

    Science.gov (United States)

    Oh, Hyunju; Quan, Shan Ai; Jeong, Jin-Young; Jang, Soong-Nang; Lee, Jung Eun; Kim, Dong-Hyun

    2013-01-01

    Background Prospective investigation of obesity and renal function decline in Asia is sparse. We examined the associations of body mass index (BMI) and waist circumference (WC) with renal function decline in a prospective study of Korean population. Methods A total of 454 participants who had baseline estimated glomerular filtration rate (eGFR) levels of more than 60 mL/min/1.73 m2 in Hallym Aging Study (HAS) were included and followed for 6 years. Renal function decline was defined as follows: (1) an eGFR decline ≥3 mL/min/1.73 m2/year (n = 82 cases); (2) an eGFR decrease of 20% or greater (n = 87 cases) at follow-up; (3) an eGFR decrease of 20% greater at follow-up or eGFR decline ≥3 mL/min/1.73 m2/year (n = 91 cases); and (4) an eGFR 95 cm in men or >90 cm in women with ≤90 cm in men or ≤85 cm in women, ORs (95% CIs) ranged from 2.31 (1.14–4.69) to 2.78 (1.19–6.50) for the 4 definitions of renal function decline (all p-values for trend Korean population. Our results provide important evidence that simple measurement of central fat deposition rather than BMI could predict decline in renal function in Korean population. PMID:23536858

  3. Clinical Implications of Associations between Headache and Gastrointestinal Disorders: A Study Using the Hallym Smart Clinical Data Warehouse.

    Science.gov (United States)

    Lee, Sang-Hwa; Lee, Jae-June; Kwon, Youngsuk; Kim, Jong-Ho; Sohn, Jong-Hee

    2017-01-01

    The brain and gastrointestinal (GI) tract are strongly connected via neural, endocrine, and immune pathways. Previous studies suggest that headaches, especially migraines, may be associated with various GI disorders. However, upper GI endoscopy in migraineurs has shown a low prevalence of abnormal findings. Also, the majority of studies have not demonstrated an association between Helicobacter pylori (HP) infection and migraine, although a pathogenic role for HP infection in migraines has been suggested. Further knowledge concerning the relation between headaches and GI disorders is important as it may have therapeutic consequences. Thus, we sought to investigate possible associations between GI disorders and common primary headaches, such as migraines and tension-type headaches (TTH), using the Smart Clinical Data Warehouse (CDW) over a period of 10 years. We retrospectively investigated clinical data using a clinical data analytic solution called the Smart CDW from 2006 to 2016. In patients with migraines and TTH who visited a gastroenterology center, GI disorder diagnosis, upper GI endoscopy findings, and results of HP infection were collected and compared to clinical data from controls, who had health checkups without headache. The time interval between headache diagnosis and an examination at a gastroenterology center did not exceed 1 year. Patients were age- and sex-matched and eligible cases were included in the migraine ( n  = 168), the TTH ( n  = 168), and the control group ( n  = 336). Among the GI disorders diagnosed by gastroenterologists, gastroesophageal reflux disorder was more prevalent in the migraine group, whereas gastric ulcers were more common in the migraine and TTH groups compared with controls ( p  < 0.0001). With regard to endoscopic findings, there were high numbers of erosive gastritis and chronic superficial gastritis cases in the migraine and TTH groups, respectively, and the severity of gastritis was significantly

  4. Parylene C Aging Studies.

    Energy Technology Data Exchange (ETDEWEB)

    Achyuthan, Komandoor; Sawyer, Patricia Sue.; Mata, Guillermo Adrian; White II, Gregory Von; Bernstein, Robert

    2014-09-01

    Parylene C is used in a device because of its conformable deposition and other advantages. Techniques to study Parylene C aging were developed, and "lessons learned" that could be utilized for future studies are the result of this initial study. Differential Scanning Calorimetry yielded temperature ranges for Parylene C aging as well as post-deposition treatment. Post-deposition techniques are suggested to improve Parylene C performance. Sample preparation was critical to aging regimen. Short-term (%7E40 days) aging experiments with free standing and ceramic-supported Parylene C films highlighted "lessons learned" which stressed further investigations in order to refine sample preparation (film thickness, single sided uniform coating, machine versus laser cutting, annealing time, temperature) and testing issues ("necking") for robust accelerated aging of Parylene C.

  5. Design Evolution Study - Aging Options

    International Nuclear Information System (INIS)

    McDaniel, P.

    2002-01-01

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new

  6. Short- and long-term outcomes of laparoscopic surgery vs open surgery for transverse colon cancer: a retrospective multicenter study

    Directory of Open Access Journals (Sweden)

    Kim JW

    2016-04-01

    Full Text Available Jong Wan Kim,1 Jeong Yeon Kim,1 Byung Mo Kang,2 Bong Hwa Lee,3 Byung Chun Kim,4 Jun Ho Park5 1Department of Surgery, Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong Si, 2Department of Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon Si, 3Department of Surgery, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Anyang Si, 4Department of Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, 5Department of Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea Purpose: The purpose of the present study was to compare the perioperative and oncologic outcomes between laparoscopic surgery and open surgery for transverse colon cancer.Patients and methods: We conducted a retrospective review of patients who underwent surgery for transverse colon cancer at six Hallym University-affiliated hospitals between January 2005 and June 2015. The perioperative outcomes and oncologic outcomes were compared between laparoscopic and open surgery.Results: Of 226 patients with transverse colon cancer, 103 underwent laparoscopic surgery and 123 underwent open surgery. There were no differences in the patient characteristics between the two groups. Regarding perioperative outcomes, the operation time was significantly longer in the laparoscopic group than in the open group (267.3 vs 172.7 minutes, P<0.001, but the time to soft food intake (6.0 vs 6.6 days, P=0.036 and the postoperative hospital stay (13.7 vs 15.7 days, P=0.018 were shorter in the laparoscopic group. The number of harvested lymph nodes was lower in the laparoscopic group than in the open group (20.3 vs 24.3, P<0.001. The 5-year overall survival (90.8% vs 88.6%, P=0.540 and disease-free survival (86.1% vs 78.9%, P=0.201 rates were similar in both groups.Conclusion: The present study showed that laparoscopic surgery is associated

  7. Comparative study on medical utilization and costs of chronic obstructive pulmonary disease with good lung function

    Directory of Open Access Journals (Sweden)

    Lim JU

    2017-09-01

    Full Text Available Jeong Uk Lim,1 Kyungjoo Kim,2 Sang Hyun Kim,3 Myung Goo Lee,4 Sang Yeub Lee,5 Kwang Ha Yoo,6 Sang Haak Lee,1 Ki-Suck Jung,7 Chin Kook Rhee,2 Yong Il Hwang7 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St Paul’s Hospital, 2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Big Data Division, Health Insurance Review and Assessment Service, Wonju, 4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, 5Department of Internal Medicine, Korea University, Anam Hospital, 6Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Republic of Korea Introduction: Patients with mild to moderate chronic obstructive pulmonary disease (COPD are underdiagnosed and undertreated due to the asymptomatic nature of the disease. Previous studies on patients with mild COPD have focused on symptomatic patients. Therefore, in this study, we evaluated the treatment status of patients with early COPD in Korea.Materials and methods: We compared hospital visits, medical costs per person, and COPD medication use by patients with COPD screened from the general population and COPD cohort patients. Patients with COPD aged ≥40 years with the value of forced expiratory volume in 1 s (FEV1 ≥60% were selected from the 2007 to 2012 Korea National Health and Nutrition Examination Survey (KNHANES data. Data including the number of outpatient clinic visits, admission to hospitals, COPD-related medications, and medical

  8. Radiogenic age and isotopic studies

    International Nuclear Information System (INIS)

    1991-01-01

    This is one of an annual collection of reports presenting data from the Geochronology Section of the Continental Geoscience Division of the Geological Survey of Canada (GSC). The main purpose of this collection is to make geochronological and other radiogenic isotope data produced by the section available promptly to the geological community. Reports make full presentation of the data, relate these to field settings and make comparatively short interpretations. Other geochronological and isotope data produced in the laboratory but published in outside journals or separate GSC publications are summarized at the end of this report. Reports in this issue give U-Pb zircon ages for rocks in Newfoundland, Yukon Territory, Manitoba, Ontario, and the Northwest Territories; present a compilation of K-Ar ages; and discuss Precambrian activity in New Brunswick, the geochronology of rock from the Northwest Territories, and reconnaissance Nd studies of rocks from the Northwest Territories. (figs., tabs., refs.)

  9. Perceived age as clinically useful biomarker of ageing: cohort study

    DEFF Research Database (Denmark)

    Christensen, Kaare; Thinggaard, Mikael; McGue, Matt

    2009-01-01

    OBJECTIVE: To determine whether perceived age correlates with survival and important age related phenotypes. DESIGN: Follow-up study, with survival of twins determined up to January 2008, by which time 675 (37%) had died. SETTING: Population based twin cohort in Denmark. PARTICIPANTS: 20 nurses, 10...... young men, and 11 older women (assessors); 1826 twins aged >or=70. MAIN OUTCOME MEASURES: Assessors: perceived age of twins from photographs. Twins: physical and cognitive tests and molecular biomarker of ageing (leucocyte telomere length). RESULTS: For all three groups of assessors, perceived age...... increased with increasing discordance in perceived age within the twin pair-that is, the bigger the difference in perceived age within the pair, the more likely that the older looking twin died first. Twin analyses suggested that common genetic factors influence both perceived age and survival. Perceived...

  10. Auxiliary feedwater system aging study

    International Nuclear Information System (INIS)

    Kueck, J.D.

    1993-07-01

    This report documents the results of a Phase I follow-on study of the Auxiliary Feedwater (AFW) System that has been conducted for the US Regulatory Commission's Nuclear Plant Aging research Program. The Phase I study found a number of significant AFW System functions that are not being adequately tested by conventional test methods and some that are actually being degraded by conventional testing. Thus, it was decided that this follow-on study would focus on these testing omissions nd equipment degradation. The deficiencies in current monitoring and operating practice are categorized and evaluated. Areas of component degradation caused by current practice are discussed. Recommendations are made for improved diagnostic methods and test procedures

  11. Auxiliary feedwater system aging study

    International Nuclear Information System (INIS)

    Kueck, J.D.

    1992-01-01

    The Phase 1 Auxiliary Feedwater (AFW) System Aging Study, NUREG/CR-5404 V1, focused on how and to what extent the various AFW system component types fail, how the failures have been and can be detected, and on the value of current testing requirements and practices. This follow-on study, which will be provided in full in NUREG/CR-5404 V2, provides a closure to the Phase 1 Study. For each of the component types and for the various sources of component failure identified in the Phase 1 Study, the methods of failure detection were designated and tabulated and the following findings became evident: Instrumentation and Control (I and C) related failures dominated the group of failures that were detected during demand conditions; many of the potential failure sources not detectable by the current monitoring practices were related to the I and C portion of the system; some component failure modes are actually aggravated by conventional test methods; and several important system functions did not undergo any function verification test. The goal of this follow-on study was to categorize and evaluate the deficiencies in testing identified by Phase 1 and to make specific recommendations for corrective action. In addition, this study presents discussions of alternate, state-of-the-art test methods, and provides a proposed Auxiliary Feedwater Pump test at normal operating pressure which should do much to verify system operability while eliminating degradation

  12. Age determination and geological studies

    International Nuclear Information System (INIS)

    Stevens, R.D.; Delabio, R.N.; Lachance, G.R.

    1982-01-01

    Two hundred and eight potassium-argon age determinations carried out on Canadian rocks and minerals are reported. Each age determination is accompanied by a description of the rock and mineral concentrate used; brief interpretative comments regarding the geological significance of each age are also provided where possible. The experimental procedures employed are described in brief outline and the constants used in the calculation of ages are listed. Two geological time-scales are reproduced in tabular form for ready reference and an index of all Geological Survey of Canada K-Ar age determinations published in this format has been prepared using NTS quadrangles as the primary reference

  13. Radiogenic age and isotopic studies

    International Nuclear Information System (INIS)

    1992-01-01

    This is one of an annual collection of reports presenting data from the Geochronology Section of the Continental Geoscience Division of the Geological Survey of Canada (GSC). The main purpose of this collection is to make geochronological and other radiogenic isotope data produced by the section available promptly to the geological community. Reports make full presentation of the data, relate these to field settings and make comparatively short interpretations. Other geochronological and isotope data produced in the laboratory but published in outside journals or separate GSC publications are summarized at the end of this report. Report 5 contains 24 papers from most regions of Canada, but particularly from British Columbia. The Geochronology Laboratory has, over the years, provided substantial U-Pb dating for the Cordilleran Division of the Geological Survey of Canada in Vancouver, and the results of a number of these studies are presented this year. A compilation of K-Ar ages is given. (figs., tabs., refs.)

  14. Differences in the risk factors of reflux esophagitis according to age in Korea.

    Science.gov (United States)

    Park, C H; Kim, K O; Baek, I H; Choi, M H; Jang, H J; Kae, S H; Kim, J B; Baik, G H; Shin, W G; Kim, K H; Kim, H Y

    2014-01-01

    The prevalence of gastroesophageal reflux disease in Korea has been believed to be low, but the incidence of gastroesophageal reflux disease in Korea is expected to increase because of the longer life expectancy and more ingestion of westernized food. The aim of this study was to report differences in the risk factors of reflux esophagitis (RE) according to age in Korea. We prospectively recruited the subjects who had RE among those who visited a health promotion center for upper gastrointestinal cancer surveillance at Hallym Medical Center (five institutions) between January 2008 and February 2009. The enrolled study participants comprised 742 subjects with RE and 1484 healthy controls. The independent risk factors of RE in young and adult group were male sex, smoking, coffee, body mass index ≥ 25, hiatal hernia, and Helicobacter pylori negativity. The risk factors of RE in elderly group were smoking, coffee, and hiatal hernia. The risk factors for RE according to age group were found to differ. In elderly group, Helicobacter pylori infection was not a significant protective factor contrary to young and adult groups. © 2012 Copyright the Authors. Journal compilation © 2012, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.

  15. Radiogenic age and isotopic studies

    International Nuclear Information System (INIS)

    Parrish, R.R.

    1990-01-01

    This is one of an annual collection of reports presenting data from the Geochronology Section of the Continental Geoscience Division of the Geological Survey of Canada (GSC). The main purpose of this collection is to make geochronological and other radiogenic isotope data produced by the section available promptly to the geological community. Reports make full presentation of the data, relate these to field settings and make comparatively short interpretations. Other geochronological and isotope data produced in the laboratory but published in outside journals or separate GSC publications are summarized at the end of this report. Reports in this issue cover methods for Rb-Sr and Sm-Nd isotopic analyses; 40 Ar- 39 Ar ages for the New Quebec Crater and for basaltic rocks; U-Pb ages for a differentiated mafic sill in the Ogilvie Mountains, plutonic rocks in the Contwoyto-Nose Lakes are, zircons from the Anton Complex, the Clinton-Colden gabbro-anorthosite intrusion, the Himag plutonic suite, the Campbell granite, the Central Gneiss Belt, Silurian granites, a metarhyolite, plagiogranite and gabbro, and the Wage shear zone; Rb-Sr ages for granitic rocks; K-Ar and Rb-Sr geochronology of granites; a compilation of K-Ar ages; ages of archean and proterozoic mylonites and pre-Misi granitoid domes; and reconnaissance geochronology of Baffin Island

  16. Study of polyurethanes ageing offshore

    Energy Technology Data Exchange (ETDEWEB)

    Aquino, Fabio G.; Sheldrake, Terry; Clevelario, Judimar; Pires, Fabio [Wellstream International, Panama City, FL (United States); Coutinho, Fernanda M.B. [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil)

    2008-07-01

    The oil industry is one of the sectors with the highest number of production systems employing high technology. Brazil is worldwide renowned as a leader in oil and gas extraction in deep and ultra deep water. Inside the production chain, a great part the oil and gas produced is conveyed through flexible pipelines that connect the production wells to the platforms. There are two segments of these lines that receive different names according to their application characteristics. When the pipes are laid on the seabed in a static service condition, are called Flow lines and when they raise from the seabed to the platform in a dynamic service condition, are called Risers. The pipes designed for dynamic applications are equipped with Bend Stiffeners, components with conical form and in general with urethane basis, which has the function of providing a smooth stiffness transition between the flexible structure of the pipes and an extremely rigid structure, the platform, not allowing that this component infringes their minimum operation Bend Radius. According to Caire, the proper compression of curvature stiffeners and the material used in its manufacture is becoming increasingly important in industry due to its growing use and the occurrence of failures that have been recorded in recent years. This paper discusses the changes in the mechanical properties of polyurethanes by the hydrolysis during accelerated ageing, reaction of water with functional groups of the polymer chain, as well as mass variation, considering that these materials are designed for a service life exceeding twenty years for operation in water. (author)

  17. Aging management and life extension - Containment aging study

    International Nuclear Information System (INIS)

    Tai, Tom M.; Deng, Daniel

    2004-01-01

    Bechtel is currently completing an aging study on a concrete containment structure. The target plant is a two-unit PWR plant with a generating capacity of about 850 MWe from each unit. Both units are less than 20 years old. The total electrical energy output from this plant site accounts for more than 50% of the utility's baseload operation. Although no utility in the United States has made a decision to submit a license renewal application, some have begun to investigate the feasibility of developing an life cycle management (LCM) program for a strategy to operate their plants efficiently, to investigate the financial benefit and safety implications of license renewal to operate their nuclear power plants beyond their current licensed periods, and to prepare a program plan for plant decommissioning. The LCM program includes economic, environmental, regulatory and technical aspects of continuing plant operations beyond the current license period. The Electric Power Research Institute (EPRI) has been supportive to assist utilities and owners groups in their research and development efforts to develop the technical requirements and the issues associated with important to license renewal structures. The focus of this paper is on the technical issues related to the evaluation of the material condition of the containment structure with respect to aging and the effective management of that aging. (author)

  18. Aging studies in atomic bomb survivors

    International Nuclear Information System (INIS)

    Belsky, J.L.; Moriyama, I.M.; Fujita, Shoichiro; Kawamoto, Sadahisa.

    1979-07-01

    Although the studies of the effect of ionizing radiation on atomic bomb survivors have not produced any evidence of radiation-induced aging, there have been studies on experimental animals and man which suggest accelerated aging after exposure to ionizing radiation. To determine if certain physiologic functions could be related to exposure to ionizing radiation, a battery of age-related tests was given at the time of the physical examinations at ABCC. Some 11,351 persons were given these non-invasive age-related tests. The results were essentially negative. Until a satisfactory operational definition of biologic or physiologic age is developed, the administration of functional tests as a measure of aging does not seem justified. (author)

  19. Aging studies in atomic bomb survivors

    International Nuclear Information System (INIS)

    Belsky, J.L.; Moriyama, I.M.; Fujita, Seiichiro; Kawamoto, Sadahisa.

    1980-01-01

    Though acceleration of aging induced by radiation could not be demonstrated in many investigations on delayed effects of ionizing radiation on a-bomb survivors, studies on acceleration of aging after the exposure to ionizing radiation in human and animals have been carried out. To investigate whether physiological function was related to the exposure to ionizing radiation, a series of examinations concerning age was carried out at the time of general health examinations at ABCC. Simple examinations concerning aging were carried out on 11,351 a-bomb survivors, but the result was essentially negative. If biological or physiological age was defined clearly, the results of functional test would be used as criterion of aging. (Tsunoda, M.)

  20. Ageing management studies of RAPS-1

    International Nuclear Information System (INIS)

    Bohra, A.K.; Jain, L.K.; Joshi, K.M.

    2006-01-01

    Unit-l of Rajasthan Atomic Power Station (RAPS-1) is the first nuclear power plant of India with pressurized heavy water reactor. The construction of Unit-l of Rajasthan Atomic Power Station (RAPS-1) was started in the year 1966 in collaboration with Canada. The Unit-1 achieved first criticality on August 1972 and was first synchronized to Grid on November 1972. During initial operation of the Unit, several problems were faced in its various systems and these were addressed by incorporating various engineering changes and procedures. In this unit various major innovative repairs were done like end shield leak repair, OPRD leak repair. Considering the operation of various systems of Unit-1, since year 1971 it was imperative to study ageing degradation mechanisms and mitigating measures were to be taken. Although the ageing management is a continuous process the opportunity of Unit-1 shutdown for upgradations from 30-04-2002 to 08-02-2004 was utilized for inspection and assessment of health of various SSC, which otherwise could not have been done with unit in operational state. This paper contains the following in detail. (1) Ageing management programme, its objectives and scope (2) Methodology of ageing management studies - Replacement and upgradation -Additional inspection programme based on ageing management review - Statistical analysis of ageing degradation occurrence - Estimation of residual life span of cables and relays (3) Criteria for selection of components for ageing management programme (4) Findings of ageing management studies-case studies. The ageing study done for RAPS-1 indicated that appropriate ageing monitoring methods and procedures exist in the station for taking timely mitigating measures. The technological obsoleteness has been overcome by installing new components of latest technology. On overall assessment, the Unit-1 was considered fit for further service. (author)

  1. Harvard Aging Brain Study : Dataset and accessibility

    NARCIS (Netherlands)

    Dagley, Alexander; LaPoint, Molly; Huijbers, Willem; Hedden, Trey; McLaren, Donald G.; Chatwal, Jasmeer P.; Papp, Kathryn V.; Amariglio, Rebecca E.; Blacker, Deborah; Rentz, Dorene M.; Johnson, Keith A.; Sperling, Reisa A.; Schultz, Aaron P.

    2017-01-01

    The Harvard Aging Brain Study is sharing its data with the global research community. The longitudinal dataset consists of a 284-subject cohort with the following modalities acquired: demographics, clinical assessment, comprehensive neuropsychological testing, clinical biomarkers, and neuroimaging.

  2. Age 60 Study. Part 1. Bibliographic Database

    Science.gov (United States)

    1994-10-01

    CMIATIONS phanocardlography, study of the arterial distensibility by the carotidogm, and the chronocudiographic meuurement of an index of systolic flow and...pilot performance and age, considering muscular strength, cardio-respiratory capacity, body weight and mental aspects). AEROSPACE MEDICINE, VOL. 42...great differences exhibited in the dynamic muscular endurance, aerobic capacity, power, agility, and coordination for the two groups. The standard

  3. Aging studies for the CMS RPC system

    CERN Document Server

    Eysermans, Jan

    2017-01-01

    Aging effects are studied for the Resistive Plate Chambers (RPC) at the Compact Muon Solenoid (CMS) experiment at the CERN Large Hadron Colider (LHC), which can manifest themselves during the High-Luminosity LHC (HL-LHC) running period. A dedicated consolidation program is set up using the CERN Gamma Irradiation Facility ++, where RPC detectors are exposed to a high gamma flux for a long term period equivalent to the HL-LHC operational time. Based on the past operational experience, the high background conditions are estimated and the RPC are tested under such circumstances. Several parameters are monitored as function of integrated charge and dedicated test beam periods allows measuring the detector efficiency as function of the background rate. In this work, an overview of the measurements which were performed for these studies is given. After having accumulated a significant amount of the total irradiation, no aging effects or degradation of the RPC detectors have been observed. These results suggest that ...

  4. Computed tomographic study of aged schizophrenic patients

    International Nuclear Information System (INIS)

    Seno, Haruo; Fujimoto, Akihiko; Ishino, Hiroshi; Shibata, Masahiro; Kuroda, Hiroyuki; Kanno, Hiroshi.

    1997-01-01

    The width of interhemispheric fissure, lateral ventricles and third ventricle were measured using cranial computed tomography (CT; linear method) in 45 elderly inpatients with chronic schizophrenia and in 28 age-matched control subjects. Twenty-three patients were men and 22 were women. In addition, Mini-Mental State Examination, Brief Psychiatric Rating Scale (BPRS) and a subclass of BPRS were undertaken in all patients. There is a significant enlargement of the maximum width of the interhemispheric fissure (in both male and female) and a significant enlargement of ventricular system (more severe in men than in women) in aged schizophrenics, as seen with CT, compared with normal controls. These findings are consistent with previous studies of non-aged schizophrenic patients. Based upon the relation between psychiatric symptoms and CT findings, the most striking is a significant negative correlation between the third ventricle enlargement and the positive and depressive symptoms in all patients. This result suggests that the advanced third ventricle enlargement may decrease these symptoms in aged schizophrenics. (author)

  5. STUDY ON NONINFECTIOUS DERMATOSES IN PAEDIATRIC AGE

    Directory of Open Access Journals (Sweden)

    Ananthi Mahalingam

    2017-09-01

    Full Text Available BACKGROUND Paediatric dermatology is a unique subspecialty in that child is not a miniature adult. Paediatric dermatoses differ from that of the adults in clinical presentation, treatment and prognosis. Various studies from India have shown infections and infestations to be the most common paediatric dermatoses. This study was planned to determine the epidemiological pattern of common noninfectious dermatoses in our paediatric patients as no such data are available from this part of the country. A cross-sectional study was undertaken to study the prevalence of the noninfectious dermatoses in all the new paediatric patients attending the Skin Outpatient Department (OPD at Villupuram Medical College over a period of three years. MATERIALS AND METHODS A total number of 550 children in the age group ranging from newborn to 12 years with noninfectious dermatoses attending the OPD for the first time were enrolled in the study. RESULTS Physiological changes of skin was the most common dermatoses in the newborn age group, while eczema was the most common dermatoses in infants, preschool and school going children. In the infants, eczema was followed by pigmentary disorders, mongolian spots, vascular nevi, ichthyosis, epidermolysis bullosa, alopecia areata and papular urticaria in the order of prevalence. Among preschool going children, eczema was followed by papular urticaria, papulosquamous disorders, pigmentary disorders, hair disorders, nevi, drug reactions, keratinisation disorders, urticaria, etc. In the school going age group, eczema was followed by papulosquamous disorders, pigmentary disorders, papular urticaria, nutritional disorders, ichthyosis, nevi, miliaria, drug reaction, hair disorders, photodermatoses, urticaria, collagen vascular disease and vascular nevi in the order of prevalence. CONCLUSION Eczema, papulosquamous disorders, papular urticaria, pigmentary disorders seem to be the most common noninfectious dermatoses in children. However

  6. Aging Studies of VCE Dismantlement Returns

    Energy Technology Data Exchange (ETDEWEB)

    Letant, S; Alviso, C; Pearson, M; Albo, R; Small, W; Wilson, T; Chinn, S; Maxwell, R

    2011-10-17

    VCE is an ethylene/vinyl acetate/vinyl alcohol terpolymer binder for filled elastomers which is designed to accept high filler loadings. Filled elastomer parts consist of the binder (VCE), a curing agent (Hylene MP, diphenol-4-4{prime}-methylenebis(phenylcarbamate)), a processing aid (LS, lithium stearate), and filler particles (typically 70% fraction by weight). The curing of the filled elastomer parts occurs from the heat-activated reaction between the hydroxyl groups of VCE with the Hylene MP curing agent, resulting in a cross-linked network. The final vinyl acetate content is typically between 34.9 and 37.9%, while the vinyl alcohol content is typically between 1.27 and 1.78%. Surveillance data for this material is both scarce and scattered, complicating the assessment of any aging trends in systems. In addition, most of the initial surveillance efforts focused on mechanical properties such as hardness and tensile strength, and chemical information is therefore lacking. Material characterization and aging studies had been performed on previous formulations of the VCE material but the Ethylene Vinyl Acetate (EVA) starting copolymer is no longer commercially available. New formulations with replacement EVA materials are currently being established and will require characterization as well as updated aging models.

  7. Harvard Aging Brain Study: Dataset and accessibility.

    Science.gov (United States)

    Dagley, Alexander; LaPoint, Molly; Huijbers, Willem; Hedden, Trey; McLaren, Donald G; Chatwal, Jasmeer P; Papp, Kathryn V; Amariglio, Rebecca E; Blacker, Deborah; Rentz, Dorene M; Johnson, Keith A; Sperling, Reisa A; Schultz, Aaron P

    2017-01-01

    The Harvard Aging Brain Study is sharing its data with the global research community. The longitudinal dataset consists of a 284-subject cohort with the following modalities acquired: demographics, clinical assessment, comprehensive neuropsychological testing, clinical biomarkers, and neuroimaging. To promote more extensive analyses, imaging data was designed to be compatible with other publicly available datasets. A cloud-based system enables access to interested researchers with blinded data available contingent upon completion of a data usage agreement and administrative approval. Data collection is ongoing and currently in its fifth year. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Estimation of Correlation between Chronological Age, Skeletal Age and Dental Age in Children- A Cross-sectional Study.

    Science.gov (United States)

    Macha, Madhulika; Lamba, Bharti; Avula, Jogendra Sai Sankar; Muthineni, Sridhar; Margana, Pratap Gowd Jai Shankar; Chitoori, Prasad

    2017-09-01

    In the modern era, identification and determination of age is imperative for diversity of reasons that include disputed birth records, premature delivery, legal issues and for validation of birth certificate for school admissions, adoption, marriage, job and immigration. Several growth assessment parameters like bone age, dental age and the combination of both have been applied for different population with variable outcomes. It has been well documented that the chronological age does not necessarily correlate with the maturational status of a child. Hence, efforts were made to determine a child's developmental age by using dental age (calcification of teeth) and skeletal age (skeletal maturation). The present study was aimed to correlate the chronological age, dental age and skeletal age in children from Southeastern region of Andhra Pradesh, India. Out of the total 900 screened children, only 100 subjects between age groups of 6-14 years with a mean age of 11.3±2.63 for males and 10.77±2.24 for females were selected for the study. Dental age was calculated by Demirjian method and skeletal age by modified Middle Phalanx of left hand third finger (MP3) method. Pearson's and Spearman's correlation tests were done to estimate the correlation between chronological, dental and skeletal ages among study population. There was a significant positive correlation between chronological age, dental age and all stages of MP3 among males. Similar results were observed in females, except for a non-significant moderate correlation between chronological age and dental age in the H stage of the MP3 region. The results of the present study revealed correlation with statistical significance (p<0.05) between chronological, dental and skeletal ages among all the subjects (48 males and 52 females) and females attained maturity earlier than males in the present study population.

  9. Study of jojoba oil aging by FTIR.

    Science.gov (United States)

    Le Dréau, Y; Dupuy, N; Gaydou, V; Joachim, J; Kister, J

    2009-05-29

    As the jojoba oil was used in cosmetic, pharmaceutical, dietetic food, animal feeding, lubrication, polishing and bio-diesel fields, it was important to study its aging at high temperature by oxidative process. In this work a FT-MIR methodology was developed for monitoring accelerate oxidative degradation of jojoba oils. Principal component analysis (PCA) was used to differentiate various samples according to their origin and obtaining process, and to differentiate oxidative conditions applied on oils. Two spectroscopic indices were calculated to report simply the oxidation phenomenon. Results were confirmed and deepened by multivariate curve resolution-alternative least square method (MCR-ALS). It allowed identifying chemical species produced or degraded during the thermal treatment according to a SIMPLISMA pretreatment.

  10. Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

    Science.gov (United States)

    O’Brien, Richard J.; Resnick, Susan M.; Zonderman, Alan B.; Ferrucci, Luigi; Crain, Barbara J.; Pletnikova, Olga; Rudow, Gay; Iacono, Diego; Riudavets, Miguel A.; Driscoll, Ira; Price, Donald L.; Martin, Lee J.; Troncoso, Juan C.

    2010-01-01

    The Baltimore Longitudinal Study of Aging (BLSA) was established in 1958 and is one the oldest prospective studies of aging in the USA and the world. The BLSA is supported by the National Institute of Aging (NIA) and its mission is to learn what happens to people as they get old and how to sort out changes due to aging and from those due to disease or other causes. In 1986, an autopsy program combined with comprehensive neurologic and cognitive evaluations was established in collaboration with the Johns Hopkins University Alzheimer’s Disease Research Center (ADRC). Since then, 211 subjects have undergone autopsy. Here we review the key clinical neuropathological correlations from this autopsy series. The focus is on the morphological and biochemical changes that occur in normal aging, and the early neuropathological changes of neurodegenerative diseases, especially Alzheimer’s disease (AD). We highlight the combined clinical, pathologic, morphometric, and biochemical evidence of asymptomatic AD, a state characterized by normal clinical evaluations in subjects with abundant AD pathology. We conclude that in some individuals, successful cognitive aging results from compensatory mechanisms that occur at the neuronal level (i.e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease. PMID:19661626

  11. Aging

    International Nuclear Information System (INIS)

    Sasaki, Hideo; Kodama, Kazunori; Yamada, Michiko

    1991-01-01

    The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bomb (A-bomb) survivors, Finch and Beebe concluded that while most studies had shown no correlation between aging and radiation exposure, they had not involved the large numbers of subjects required to provide strong evidence for or against the hypothesis. Extending LSS mortality data up to 1978 did not alter the earlier conclusion that any observed life-shortening was associated primarily with cancer induction rather than with any nonspecific cause. The results of aging studies conducted during the intervening 15 years using data from the same populations are reviewed in the present paper. Using clinical, epidemiological, and laboratory techniques, a broad spectrum of aging parameters have been studied, such as postmortem morphological changes, tests of functional capacity, physical tests and measurements, laboratory tests, tissue changes, and morbidity. With respect to the aging process, the overall results have not been consistent and are generally thought to show no relation to radiation exposure. Although some preliminary results suggest a possible radiation-induced increase in atherosclerotic diseases and acceleration of aging in the T-cell-related immune system, further study is necessary to confirm these findings. In the future, applying the latest gerontological study techniques to data collected from subjects exposed 45 years ago to A-bomb radiation at relatively young ages will present a new body of data relevant to the study of late radiation effects. (author) 103 refs

  12. Aging study of the powdered magnetite nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Umar Saeed, E-mail: omar_aps@yahoo.co.uk [Department of Physics, University of Peshawar (Pakistan); Rahim, Abdur, E-mail: rahimkhan533@gmail.com [Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Lahore (Pakistan); Khan, Nasrullah [Department of Physics, Kohat University of Science and Technology, Kohat (Pakistan); Muhammad, Nawshad; Rehman, Fozia [Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Lahore (Pakistan); Ahmad, Khalid [Institute of Chemistry, State University of Campinas, PO Box 6154, 13083-970 Campinas, SP (Brazil); Iqbal, Jibran [College of Natural and Health Sciences, Zayed University, 144534 Abu Dhabi (United Arab Emirates)

    2017-03-01

    Magnetite nanoparticles were produced via co-precipitation method and then stored at room temperature for 6 years in aerobic atmosphere. Variations in the inherent solid phase and solid interfacial properties of the prepared magnetite nanoparticles were investigated. For this purpose the fresh and aged samples were characterized using transmission electron microscopy, vibrating sample magnetometer, X-ray diffractometer and energy dispersive X-ray spectrometer. The solid phase transformations of magnetite nanoparticles to maghemite nanoparticles as well as formation of other iron oxides were happened. After aging of 6 years, no change was occurred in the magnetic features; however increase in particle size from 9.6 to 18.5 measured by transmission electron microscopy was confirmed. The crystallite size and vibrating sample magnetometer values were measured before and after aging and found to increase from 8.98 nm and 47.23 emu/g to 16.18 nm and 58.36 emu/g respectively. The formation of other iron oxides, recrystallization and agglomeration during aging process, caused a significant decrease in the specific surface area from 124.43 to 45.00 m{sup 2}/g of the stored sample. - Highlights: • Magnetite nanoparticles (NPs) were produced via co-precipitation method. • Inherent solid phase and interfacial properties of NP were evaluated after 6 years. • The solid phase transformations of magnetite NPs to maghemite NPs was happened. • After aging of 6 years, no change was occurred in the magnetic features.

  13. Aging study of the powdered magnetite nanoparticles

    International Nuclear Information System (INIS)

    Khan, Umar Saeed; Rahim, Abdur; Khan, Nasrullah; Muhammad, Nawshad; Rehman, Fozia; Ahmad, Khalid; Iqbal, Jibran

    2017-01-01

    Magnetite nanoparticles were produced via co-precipitation method and then stored at room temperature for 6 years in aerobic atmosphere. Variations in the inherent solid phase and solid interfacial properties of the prepared magnetite nanoparticles were investigated. For this purpose the fresh and aged samples were characterized using transmission electron microscopy, vibrating sample magnetometer, X-ray diffractometer and energy dispersive X-ray spectrometer. The solid phase transformations of magnetite nanoparticles to maghemite nanoparticles as well as formation of other iron oxides were happened. After aging of 6 years, no change was occurred in the magnetic features; however increase in particle size from 9.6 to 18.5 measured by transmission electron microscopy was confirmed. The crystallite size and vibrating sample magnetometer values were measured before and after aging and found to increase from 8.98 nm and 47.23 emu/g to 16.18 nm and 58.36 emu/g respectively. The formation of other iron oxides, recrystallization and agglomeration during aging process, caused a significant decrease in the specific surface area from 124.43 to 45.00 m"2/g of the stored sample. - Highlights: • Magnetite nanoparticles (NPs) were produced via co-precipitation method. • Inherent solid phase and interfacial properties of NP were evaluated after 6 years. • The solid phase transformations of magnetite NPs to maghemite NPs was happened. • After aging of 6 years, no change was occurred in the magnetic features.

  14. Aging

    International Nuclear Information System (INIS)

    Finch, S.C.; Beebe, G.W.

    1975-01-01

    The hypothesis that ionizing radiation accelerates natural aging has been under investigation at the Atomic Bomb Casualty Commission since 1959. Postmortem observations of morphologic and chemical changes, tests of functional capacity, physical tests and measurements, clinical laboratory tests, tissue changes, morbidity, and mortality have all been examined by ABCC investigators interested in this hypothesis. These studies have been beset with conceptual difficulties centered on the definition and measurement of aging. An empirical approach early led to the calculation of an index of physiologic age as a linear combination of age-related tests of various organ systems. Most studies have been negative but have not involved the large numbers that might be required to provide strong evidence for or against the hypothesis. Mortality, however, has been examined on the basis of a large sample and over the period 1950-1972 had provided no support for the hypothesis of radiation-accelerated aging. Ionizing radiation dose, of course shorten human life, but its life-shortening effect appears to be the result of specific radiation-induced disease, especially neoplasms. The hypothesis is now much less attractive than it was 10-20 years ago but still has some value in stimulating research on aging. The experience of the A-bomb survivors provides an unusual opportunity for a definitive test of the hypothesis. (auth.)

  15. Aging study on atomic bomb survivors

    International Nuclear Information System (INIS)

    Okajima, Shunzo; Aoyama, Takashi; Norimura, Toshiyuki; Nishimori, Issei; Shiomi, Toshio

    1976-01-01

    This is an ad interim report on the survey which is being performed at the Atomic Disease Institute, Nagasaki University School of Medicine for the acceleration of aging in atomic bomb survivors. The survivors group consisted of 50 females between 40 and 49 years of age who were exposed somewhere within 1.4 km where exposure dose could be estimated accurately and whose mean estimated exposure dose was 225.9+-176.8 rads. The control group consisted of females of the same age group who were exposed at sites more than 2.5 km apart (atmospheric dose 2.9 rads). The items for the judgement of aging included physical measurements, external findings, functional findings, and special tests (urine, blood, pattern of serum protein fraction, and chromosome aberrations). As far as chromosome aberrations were concerned, the number of cells with stable aberrations, Cs, showed differences between the two groups, and the number of cells with exchange-type aberrations was large in the survivors group. No significant differences were observed in the other tests. (Serizawa, K.)

  16. Aging road user studies of intersection safety.

    Science.gov (United States)

    2014-10-01

    Task 1.1 assessed younger (21-35 years), middle-aged (50-64 years), and older (65+) drivers ability to : quickly perceive the presence of marked/unmarked crosswalks and pedestrians within them in computer-based : laboratory tasks that recorded res...

  17. Managing aging workers: a mixed methods study on bundles of HR practices for aging workers

    NARCIS (Netherlands)

    Kooij, Dorien T. A. M.; Jansen, Paul G. W.; Dikkers, Josje S. E.; de Lange, Annet H.

    2014-01-01

    Since abilities and motives change with age and common human resource (HR) practices might be less suitable for aging employees, scholars and practitioners are currently challenged to find new ways of managing aging workers and motivating them to continue working. Therefore, this mixed methods study

  18. Late Bronze Age hoard studied by PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez Neira, P.C., E-mail: carolina.gutierrez@uam.es [CMAM, Universidad Autonoma de Madrid, c/Farady 3, E-28049 Madrid (Spain); Zucchiatti, A., E-mail: alessandro.zucchiatti@uam.es [CMAM, Universidad Autonoma de Madrid, c/Farady 3, E-28049 Madrid (Spain); Montero-Ruiz, I., E-mail: ignacio.montero@cchs.csic.es [CCHS-CSIC, Albasanz 26-28, E 28037 Madrid (Spain); Vilaca, R., E-mail: rvilaca@fl.uc.pt [University of Coimbra, Largo da Porta Ferrea, 3000-447 Coimbra (Portugal); Bottaini, C., E-mail: keret18@yahoo.it [University of Coimbra, Largo da Porta Ferrea, 3000-447 Coimbra (Portugal); Gener, M., E-mail: marc.gener@cchs.csic.es [CCHS-CSIC, Albasanz 26-28, E 28037 Madrid (Spain); Climent-Font, A., E-mail: acf@uam.es [CMAM, Universidad Autonoma de Madrid, c/Farady 3, E-28049 Madrid (Spain); Department of Applied Physics, Universidad Autonoma de Madrid, Campus Cantobalanco, E-28049 Madrid (Spain)

    2011-12-15

    The hoards of metallic objects belonging to the Late European Bronze Age can be interpreted differently depending on the type, number and composition of the artefacts. PIXE analysis has been performed in nine items from the Hoard of Freixanda in Portugal comprising four socket axes, a palstave axe, a ring, a chisel, a dagger, and a casting debris. Besides the composition of the main matrix elements, that is Cu and Sn, the amount of trace elements of interest like, As, Pb, Ni, and Ag has been determined using this ion beam technique. The high tin content alloy and the high purity of the metals from the Freixanda hoard are characteristic of the Portuguese and Spanish Late Bronze Age metallurgy, supporting the idea of a regional production.

  19. Study of ageing effects in aerogel

    International Nuclear Information System (INIS)

    Bellunato, T.; Calvi, M.; Coluzza, C.; Longo, G.; Matteuzzi, C.; Musy, M.; Negri, P.; Perego, D.L.

    2004-01-01

    Ageing effects on aerogel due to irradiation and absorption of humidity have been investigated. Aerogel tiles have been exposed to γ radiation from a 60 Co source and to proton and neutron high intensity beams. The transmittance has been monitored in the wavelength range between 200 and 800 nm, determining the clarity factor C as a function of the increasing dose of irradiation. The index of refraction n was also measured

  20. Study of ageing effects in aerogel

    CERN Document Server

    Bellunato, T F; Coluzza, C; Longo, G; Matteuzzi, C; Musy, M; Negri, P; Perego, D L

    2004-01-01

    Ageing effects on aerogel due to irradiation and absorption of humidity have been investigated. Aerogel tiles have been exposed to gamma radiation from a 60-Co source and to proton and neutron high intensity beams. The transmittance has been monitored in the wavelength range between 200 nm and 800 nm, determining the clarity factor C as a function of the increasing dose of irradiation. The index of refraction n was also measured.

  1. Clinical studies of renal morphological changes with aging

    International Nuclear Information System (INIS)

    Hosokawa, Shin-ichi; Kawamura, Juichi; Tomoyoshi, Tadao; Yoshida, Osamu

    1980-01-01

    We studied the change of renal shape due to development and aging by using sup(99m)Tc-DMSA renal scintigraphy. In pediatric age group, the angle between renal longitudinal axis and the lumbar vertebrae is small but becomes larger with aging. The renal size grows with aging in the adult age group, and becomes largest. In geriatric age group it decreases with aging. The stability of renal position is marked in the adult age group, but in the pediatric and geriatric age group it seemed unstable. Renal contour is smooth in the pediatric and adult age group but unsmooth in the geriatric. sup(99m)Tc-DMSA renal image shows diffusely homogeneous renal uptake in the pediatric and adult age groups but not homogeneous in the geriatric. (author)

  2. Rubidium-strontium and uranium-lead isotopic age studies

    International Nuclear Information System (INIS)

    Loveridge, W.D.

    1981-01-01

    The results of five Rb-Sr isotopic age studies predominantly on whole-rock samples, and six U-Pb studies on zircon monazite concentrates are presented. Descriptions of the geological problems and interpretations of the measured ages are included. Laboratory age determination methods and techniques are described or referenced

  3. Study of the aging processes in polyurethane adhesives using thermal treatment and differential calorimetric, dielectric, and mechanical techniques ; 1, identifying the aging processes ; 2, quantifying the aging effect

    CERN Document Server

    Althouse, L P

    1979-01-01

    Study of the aging processes in polyurethane adhesives using thermal treatment and differential calorimetric, dielectric, and mechanical techniques ; 1, identifying the aging processes ; 2, quantifying the aging effect

  4. Differences in physical aging measured by walking speed: evidence from the English Longitudinal Study of Ageing.

    Science.gov (United States)

    Weber, Daniela

    2016-01-28

    Physical functioning and mobility of older populations are of increasing interest when populations are aging. Lower body functioning such as walking is a fundamental part of many actions in daily life. Limitations in mobility threaten independent living as well as quality of life in old age. In this study we examine differences in physical aging and convert those differences into the everyday measure of single years of age. We use the English Longitudinal Study of Ageing, which was collected biennially between 2002 and 2012. Data on physical performance, health as well as information on economics and demographics of participants were collected. Lower body performance was assessed with two timed walks at normal pace each of 8 ft (2.4 m) of survey participants aged at least 60 years. We employed growth curve models to study differences in physical aging and followed the characteristic-based age approach to illustrate those differences in single years of age. First, we examined walking speed of about 11,700 English individuals, and identified differences in aging trajectories by sex and other characteristics (e.g. education, occupation, regional wealth). Interestingly, higher educated and non-manual workers outperformed their counterparts for both men and women. Moreover, we transformed the differences between subpopulations into single years of age to demonstrate the magnitude of those gaps, which appear particularly high at early older ages. This paper expands research on aging and physical performance. In conclusion, higher education provides an advantage in walking of up to 15 years for men and 10 years for women. Thus, enhancements in higher education have the potential to ensure better mobility and independent living in old age for a longer period.

  5. Aging Trajectories in Different Body Systems Share Common Environmental Etiology: The Healthy Aging Twin Study (HATS).

    Science.gov (United States)

    Moayyeri, Alireza; Hart, Deborah J; Snieder, Harold; Hammond, Christopher J; Spector, Timothy D; Steves, Claire J

    2016-02-01

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal clinical data were collected on 3,508 female twins in the TwinsUK registry (complete pairs:740 monozygotic (MZ), 986 dizygotic (DZ), mean age at entry 48.9 ± 10.4, range 18-75 years; mean follow-up 10.2 ± 2.8 years, range 4-17.8 years). Panel data on multiple age-related variables were used to estimate biological ages for each individual at each time point, in linear mixed effects models. A weighted average approach was used to combine variables within predefined body system groups. Aging trajectories for each system in each individual were then constructed using linear modeling. Multivariate structural equation modeling of these aging trajectories showed low genetic effects (heritability), ranging from 2% in metabolic aging to 22% in cardiovascular aging. However, we found a significant effect of shared environmental factors on the variations in aging trajectories in cardiovascular (54%), skeletal (34%), morphometric (53%), and metabolic systems (53%). The remainder was due to environmental factors unique to each individual plus error. Multivariate Cholesky decomposition showed that among aging trajectories for various body systems there were significant and substantial correlations between the unique environmental latent factors as well as shared environmental factors. However, there was no evidence for a single common factor for aging. This study, the first of its kind in aging, suggests that diverse organ systems share non-genetic sources of variance for aging trajectories. Confirmatory studies are needed using population-based twin cohorts and alternative methods of handling missing data.

  6. Is There Successful Aging for Nonagenarians? The Vitality 90+ Study

    Directory of Open Access Journals (Sweden)

    Lily Nosraty

    2012-01-01

    Full Text Available Objectives. This study was designed (1 to estimate the prevalence of successful aging among nonagenarians based on six different models and (2 to investigate whether successful aging is associated with socio-demographic factors. Methods. A mailed survey was conducted with people aged 90+ in Tampere in 2010. Responses were received from 1283 people. The prevalence of successful aging was measured by six multidimensional models including physical, social, and psychological components. Age, sex, marital status, level of education, and place of living were studied as factors associated with successful aging. Results. The prevalence of successful aging varied from 1.6% to 18.3% depending on the model applied. Successful aging was more prevalent in men, and also more prevalent among community-living people. In most models, successful aging was also associated with younger age, being married, and a higher level of education. Discussion. Models which emphasize the absence of disease and activity as criteria for successful aging may not be the most relevant and applicable in oldest old. Instead, preference should be given to models that focus more on autonomy, adaptation and sense of purpose. Age-sensitive approaches would help us better understand the potential of successful aging among individuals who already have success in longevity.

  7. Organic Tanks Safety Program: Waste aging studies

    International Nuclear Information System (INIS)

    Camaioni, D.M.; Samuels, W.D.; Lenihan, B.D.; Clauss, S.A.; Wahl, K.L.; Campbell, J.A.

    1994-11-01

    The underground storage tanks at the Hanford Complex contain wastes generated from many years of plutonium production and recovery processes, and mixed wastes from radiological degradation processes. The chemical changes of the organic materials used in the extraction processes have a direct on several specific safety issues, including potential energy releases from these tanks. This report details the first year's findings of a study charged with determining how thermal and radiological processes may change the composition of organic compounds disposed to the tank. Their approach relies on literature precedent, experiments with simulated waste, and studies of model reactions. During the past year, efforts have focused on the global reaction kinetics of a simulated waste exposed to γ radiation, the reactions of organic radicals with nitrite ion, and the decomposition reactions of nitro compounds. In experiments with an organic tank non-radioactive simulant, the authors found that gas production is predominantly radiolytically induced. Concurrent with gas generation they observe the disappearance of EDTA, TBP, DBP and hexone. In the absence of radiolysis, the TBP readily saponifies in the basic medium, but decomposition of the other compounds required radiolysis. Key organic intermediates in the model are C-N bonded compounds such as oximes. As discussed in the report, oximes and nitro compounds decompose in strong base to yield aldehydes, ketones and carboxylic acids (from nitriles). Certain aldehydes can react in the absence of radiolysis to form H 2 . Thus, if the pathways are correct, then organic compounds reacting via these pathways are oxidizing to lower energy content. 75 refs

  8. Age differences in the motor control of speech: An fMRI study of healthy aging.

    Science.gov (United States)

    Tremblay, Pascale; Sato, Marc; Deschamps, Isabelle

    2017-05-01

    Healthy aging is associated with a decline in cognitive, executive, and motor processes that are concomitant with changes in brain activation patterns, particularly at high complexity levels. While speech production relies on all these processes, and is known to decline with age, the mechanisms that underlie these changes remain poorly understood, despite the importance of communication on everyday life. In this cross-sectional group study, we investigated age differences in the neuromotor control of speech production by combining behavioral and functional magnetic resonance imaging (fMRI) data. Twenty-seven healthy adults underwent fMRI while performing a speech production task consisting in the articulation of nonwords of different sequential and motor complexity. Results demonstrate strong age differences in movement time (MT), with longer and more variable MT in older adults. The fMRI results revealed extensive age differences in the relationship between BOLD signal and MT, within and outside the sensorimotor system. Moreover, age differences were also found in relation to sequential complexity within the motor and attentional systems, reflecting both compensatory and de-differentiation mechanisms. At very high complexity level (high motor complexity and high sequence complexity), age differences were found in both MT data and BOLD response, which increased in several sensorimotor and executive control areas. Together, these results suggest that aging of motor and executive control mechanisms may contribute to age differences in speech production. These findings highlight the importance of studying functionally relevant behavior such as speech to understand the mechanisms of human brain aging. Hum Brain Mapp 38:2751-2771, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  9. Age and fecundability in a North American preconception cohort study.

    Science.gov (United States)

    Wesselink, Amelia K; Rothman, Kenneth J; Hatch, Elizabeth E; Mikkelsen, Ellen M; Sørensen, Henrik T; Wise, Lauren A

    2017-12-01

    There is a well-documented decline in fertility treatment success with increasing female age; however, there are few preconception cohort studies that have examined female age and natural fertility. In addition, data on male age and fertility are inconsistent. Given the increasing number of couples who are attempting conception at older ages, a more detailed characterization of age-related fecundability in the general population is of great clinical utility. The purpose of this study was to examine the association between female and male age with fecundability. We conducted a web-based preconception cohort study of pregnancy planners from the United States and Canada. Participants were enrolled between June 2013 and July 2017. Eligible participants were 21-45 years old (female) or ≥21 years old (male) and had not been using fertility treatments. Couples were followed until pregnancy or for up to 12 menstrual cycles. We analyzed data from 2962 couples who had been trying to conceive for ≤3 cycles at study entry and reported no history of infertility. We used life-table methods to estimate the unadjusted cumulative pregnancy proportion at 6 and 12 cycles by female and male age. We used proportional probabilities regression models to estimate fecundability ratios, the per-cycle probability of conception for each age category relative to the referent (21-24 years old), and 95% confidence intervals. Among female patients, the unadjusted cumulative pregnancy proportion at 6 cycles of attempt time ranged from 62.0% (age 28-30 years) to 27.6% (age 40-45 years); the cumulative pregnancy proportion at 12 cycles of attempt time ranged from 79.3% (age 25-27 years old) to 55.5% (age 40-45 years old). Similar patterns were observed among male patients, although differences between age groups were smaller. After adjusting for potential confounders, we observed a nearly monotonic decline in fecundability with increasing female age, with the exception of 28-33 years, at which

  10. Study of aging and ordering processes in titanium carbide

    International Nuclear Information System (INIS)

    Arbuzov, M.P.; Khaenko, B.V.; Kachkovskaya, Eh.T.

    1977-01-01

    Aging and ordering processes in titanium carbide were investigated on monocrystals (fragments of alloys) with the aid of roentgenographic method. The sequence of phase transformations during aging was ascertained,and a monoclinic structure of the carbon atoms ordering is suggested. The microhardness of titanium carbide was studied as a function of the heat treatment of alloys and the main factors (ordering and dislocation structure) which govern the difference in the microhardness of hardened and aged (annealed) specimens were determined

  11. Rheological Study of Ageing Soft Glasses of Laponite

    Indian Academy of Sciences (India)

    Table of contents. Rheological Study of Ageing Soft Glasses of Laponite · Colloidal glasses · Laponite Na+0.7[(Si8Mg5.5Li0.3)O20(OH)4]–0.7 · Effect of salt (NaCl) · Arrested state · Relaxation dynamics · Rheology of aging system · Slide 8 · Experimental Protocol · Ageing and Creep experiments · Slide 11 · Slide 12.

  12. Retirement age and the age of onset of Alzheimer's disease: results from the ICTUS study.

    Directory of Open Access Journals (Sweden)

    Catherine Grotz

    Full Text Available To test whether deferred retirement is associated with delayed onset of Alzheimer's disease (AD, and, if so, to determine whether retirement age still predicts the age at onset of AD when two potential biases are considered.The study sample was gathered from the Impact of Cholinergic Treatment Use/Data Sharing Alzheimer cohort (ICTUS/DSA, a European study of 1,380 AD patients. Information regarding retirement age, onset of symptoms and covariates was collected at baseline whereas age at diagnosis was gathered from the patient's medical record prior to study entry. Linear mixed models, adjusted for gender, education, occupation, center, country, household income, depression and cardiovascular risk factors were conducted on 815 patients.(1 The global analyses (n = 815 revealed that later age at retirement was associated with later age at diagnosis (β = 0.31, p < 0.0001; (2 once the selection bias was considered (n = 637, results showed that this association was weaker but remained significant (β = 0.15, p = 0.004; (3 once the bias of the reverse causality (i.e., the possibility that subjects may have left the workforce due to prior cognitive impairment was considered (n = 447, the effect was no longer significant (β = 0.06, p = 0.18.The present study supports that there is an association between retirement age and age at onset of AD. However, the strength of this association appears to be overestimated due to the selection bias. Moreover, the causality issue remains unresolved. Further prospective investigations are mandatory in order to correctly address this question.

  13. Subjective age and personality development: a 10-year study.

    Science.gov (United States)

    Stephan, Yannick; Sutin, Angelina R; Terracciano, Antonio

    2015-04-01

    Personality theory and research typically focus on chronological age as a key indicator of personality development. This study examines whether the subjective experience of age is an alternative marker of the biomedical and psychosocial factors that contribute to individual differences in personality development. The present study uses data from the Midlife in the United States longitudinal survey (N = 3,617) to examine how subjective age is associated with stability and change in personality and the dynamic associations between subjective age and personality traits over a 10-year period. Regression analyses indicated that a younger subjective age at baseline was associated with increases in Openness, Conscientiousness, and Agreeableness; correlated changes were also found. The rank-order stability of Extraversion and Openness and overall profile consistency were higher among those with a younger subjective age at baseline and were also associated with the rate of subjective aging over time. The present study reveals that beyond chronological age, the age an individual feels is related to changes in characteristic ways of thinking, feeling, and behaving over time. © 2014 Wiley Periodicals, Inc.

  14. Pilot study protocol to inform a future longitudinal study of ageing using linked administrative data: Healthy AGeing in Scotland (HAGIS).

    Science.gov (United States)

    Douglas, Elaine; Rutherford, Alasdair; Bell, David

    2018-01-10

    Population ageing is a welcome testament to improvements in the social, economic and health circumstances over the life course. However, these successes necessitate that we understand more about the pathways of ageing to plan and cost our health and social care services, to support our ageing population to live healthier for longer and to make adequate provisions for retirement. Longitudinal studies of ageing facilitate such understanding in many countries around the world. Scotland presently does not have a longitudinal study of ageing, despite dramatic increases to its ageing population and its poor health record. Healthy AGeing in Scotland (HAGIS) constitutes the launch of Scotland's first comprehensive longitudinal study of ageing. A sample of 1000 people aged 50+ years will be invited to take part in a household social survey. The innovative sampling procedure used administrative data to identify eligible households. Anonymised survey responses will be linked to administrative data. Ethics approval was obtained from the host institution for the study design and from the Public Benefits and Privacy Panel for administrative data linkage. Anonymised survey data will be deposited with the UK Data Service. A subset of survey data, harmonised with other global ageing studies, will be available via the Gateway to Global Aging platform. These data will enable powerful cross-country comparisons across the social, economic and health domains that will be relevant for national and international research.Research publications from the HAGIS team will be disseminated through journal articles and national and international conferences. The findings will support current and future research and policy debate on ageing populations. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  15. Aging and Alzheimer's Disease: Lessons from the Nun Study.

    Science.gov (United States)

    Snowdon, David A.

    1997-01-01

    Describes a woman who maintained high cognitive test scores until her death at 101 years of age despite anatomical evidence of Alzheimer's disease. The woman was part of a larger "Nun Study" in which 678 sisters donated their brains to teach others about the etiology of aging and Alzheimer's disease. Findings are discussed. (RJM)

  16. Study on kinetic of strain-aging in zircaloy-4

    International Nuclear Information System (INIS)

    Gomes, P.A.

    1977-01-01

    The strain-aging in zircaloy-4 has been investigated in this work and a study of the general problems involving this phenomenon has been realized in Zirconium and its alloys. It has been verified that a yield point appears in the Zircaloy-4, when it is submitted to strain-aging treatment between the temperatures 200 0 C and 400 0 C. (author)

  17. Age

    Science.gov (United States)

    ... adults? How can you reduce anesthesia risks in older patients? Age Age may bring wisdom but it also brings ... Ask your physician to conduct a pre-surgery cognitive test — an assessment of your mental function. The physician can use the results as a ...

  18. Healthy ageing in the Nun Study: definition and neuropathologic correlates.

    Science.gov (United States)

    Tyas, Suzanne L; Snowdon, David A; Desrosiers, Mark F; Riley, Kathryn P; Markesbery, William R

    2007-11-01

    Although the concept of healthy ageing has stimulated considerable interest, no generally accepted definition has been developed nor has its biological basis been determined. To develop a definition of healthy ageing and investigate its association with longevity and neuropathology. Analyses were based on cognitive, physical, and post-mortem assessments from 1991 to 1998 in the Nun Study, a longitudinal study of ageing in participants 75+ years at baseline. We defined three mutually exclusive levels of healthy ageing (excellent, very good, and good) based on measures of global cognitive function, short-term memory, basic and instrumental activities of daily living, and self-rated function. Mortality analyses were based on 636 participants; neuropathologic analyses were restricted to 221 who had died and were autopsied. Only 11% of those meeting criteria for the excellent level of healthy ageing at baseline subsequently died, compared with 24% for the very good, 39% for the good, and 60% for the remaining participants. Survival curves showed significantly greater longevity with higher levels of healthy ageing. The risk of not attaining healthy ageing, adjusted for age, increased two-fold in participants with brain infarcts alone, six-fold in those with Alzheimer neuropathology alone, and more than thirteen-fold in those with both brain infarcts and Alzheimer neuropathology. The biological validity of our definition of healthy ageing is supported by its strong association with mortality and longevity. Avoiding Alzheimer and stroke neuropathology is critical to the maintenance of healthy ageing, and the presence of both pathologies dramatically decreases the likelihood of healthy ageing.

  19. A longitudinal study of brain volume changes in normal aging

    Energy Technology Data Exchange (ETDEWEB)

    Takao, Hidemasa, E-mail: takaoh-tky@umin.ac.jp [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Hayashi, Naoto [Department of Computational Diagnostic Radiology and Preventive Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Ohtomo, Kuni [Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan)

    2012-10-15

    Purpose: To evaluate the effect of normal aging on brain volumes and examine the effects of age and sex on the rates of changes in global and regional brain volumes. Methods: A total of 199 normal subjects (65 females and 134 males, mean age = 56.4 ± 9.9 years, age range = 38.1–82.9 years) were included in this study. Each subject was scanned twice, at an interval of about 2 years (range = 1.5–2.3 years). Two-time-point percentage brain volume change (PBVC) was estimated with SIENA 2.6. Results: The mean annualized PBVC was −0.23%/y. Analysis of covariance (ANCOVA) for annual brain volume changes revealed a main effect of age. There was no main effect of sex, nor was there a sex-by-age interaction. Voxel-wise analysis revealed a negative correlation between age and edge displacement values mainly in the periventricular region. Conclusions: The results of our study indicate that brain atrophy accelerates with increasing age and that there is no gender difference in the rate of brain atrophy.

  20. A longitudinal study of brain volume changes in normal aging

    International Nuclear Information System (INIS)

    Takao, Hidemasa; Hayashi, Naoto; Ohtomo, Kuni

    2012-01-01

    Purpose: To evaluate the effect of normal aging on brain volumes and examine the effects of age and sex on the rates of changes in global and regional brain volumes. Methods: A total of 199 normal subjects (65 females and 134 males, mean age = 56.4 ± 9.9 years, age range = 38.1–82.9 years) were included in this study. Each subject was scanned twice, at an interval of about 2 years (range = 1.5–2.3 years). Two-time-point percentage brain volume change (PBVC) was estimated with SIENA 2.6. Results: The mean annualized PBVC was −0.23%/y. Analysis of covariance (ANCOVA) for annual brain volume changes revealed a main effect of age. There was no main effect of sex, nor was there a sex-by-age interaction. Voxel-wise analysis revealed a negative correlation between age and edge displacement values mainly in the periventricular region. Conclusions: The results of our study indicate that brain atrophy accelerates with increasing age and that there is no gender difference in the rate of brain atrophy

  1. [Aging of cognitive functions. Results of a longitudinal study].

    Science.gov (United States)

    Poitrenaud, J; Barrère, H; Darcet, P; Driss, F

    1983-12-29

    This study had the two following purposes: to assess the age-related changes in the fluid and crystallized components of intelligence in subjects over age sixty five; to examine whether these age-related changes were linked to any biological, psychological and social factors. The sample was composed of 50 male subjects who were examined three times: in 1968, 1973 and 1977. At the beginning of the study, their age ranged from 60 to 79 years and they were all in good health. In the whole, their socio-economic level was high. At each wave of the study, these subjects were given the same battery of three mental tests: a vocabulary test, selected to assess crystallized intelligence; a perceptual test and a speeded digit coding test, both selected to assess fluid intelligence. Results show that the two components of intelligence have different aging trajectories over age sixty. On the vocabulary test, performances hold until an advanced age (about 75-80), then significantly decline. On the perceptual and digit coding tests, performances sharply and significantly decline with age, this decline looking approximately linear. Whatever the test used, individual differences in age-related changes in performance are found to be great. On vocabulary test, this variability is linked to two factors, independently of age: among subjects who have suffered from a cardio-arterial disease between wave 1 and wave 3, as well as in those who have not maintained an occupational activity, decline in performance is greater than in other subjects. On the two other tests, no factor was found to be significantly linked with change in performance between wave 1 and wave 3.

  2. Ageing of cables and new approach for the study of polymer ageing

    International Nuclear Information System (INIS)

    Monchy-Leroy, C.; Therond, P.

    2011-01-01

    The study of nuclear cable ageing has become an important subject in particular within the framework of the lifetime extension of nuclear power plants. Until 2000, the approach developed by EDF was a purely empirical one, which establishes from a behavior law, the temporal evolution of a macroscopic property of the jacket or the insulation (generally elongation at break), according to the ageing conditions, such as the temperature and the dose rate. These simulations, coupled with analyses of cables taken on sites after several years of ageing, can demonstrate and justify the good behavior in time of the cables installed in the French nuclear power plants. However from an industrial point of view, this approach, as any empirical approach, is not sustainable and suffers numerous limitations. In particular, the results obtained are not transposable from one industrial formulation to another. That is why for some years, EDF has developed a more generic approach based on the understanding and the modeling of the ageing of polymers by thermo-oxidation and radio-oxidation. This new approach consists of identifying all the occurring reactions at the molecular scale during the polymer ageing. The numerical resolution of the system of differential equations stemming from the scheme of reactions, allows access to the spatial and temporal distributions of the oxidation products formed during the ageing. Today the studies are focused on elastomer matrices of type Polyethylene (PE) and co-polymers of type Ethylene-Propylene-Rubber (EPR) to which were added stabilizers and fillers. Later, the model will allow us to simulate the ageing of any industrial polymer. (authors)

  3. Healthy aging and dementia: findings from the Nun Study.

    Science.gov (United States)

    Snowdon, David A

    2003-09-02

    The Nun Study is a longitudinal study of 678 Catholic sisters 75 to 107 years of age who are members of the School Sisters of Notre Dame congregation. Data collected for this study include early and middle-life risk factors from the convent archives, annual cognitive and physical function evaluations during old age, and postmortem neuropathologic evaluations of the participants' brains. The case histories presented include a centenarian who was a model of healthy aging, a 92-year-old with dementia and clinically significant Alzheimer disease neuropathology and vascular lesions, a cognitively and physically intact centenarian with almost no neuropathology, and an 85-year-old with well-preserved cognitive and physical function despite a genetic predisposition to Alzheimer disease and an abundance of Alzheimer disease lesions. These case histories provide examples of how healthy aging and dementia relate to the degree of pathology present in the brain and the level of resistance to the clinical expression of the neuropathology.

  4. AGE DETERMINATION FROM PUBIC SYMPHYSEAL CHANGES- AN AUTOPSY STUDY

    Directory of Open Access Journals (Sweden)

    Jinesh Parambathettu Sasidharan

    2017-02-01

    Full Text Available BACKGROUND Biological identity is one of the first things to be established when analysing skeletal, badly decomposed or otherwise unidentified human remains. The determination of age at death is an important component of identity establishment. Pubic symphysis examination is one of the reliable methods of age estimation. We attempt to determine the age of deceased from pubic symphysis using Suchey-Brooks method and to find the accuracy of Suchey-Brooks method in our population. From among the cases brought for autopsy at Department of Forensic Medicine, Government Medical College, Kottayam, Kerala, from 01/03/2012 to 28/02/2013, 316 cases were included in the study. Their pubic symphysis were harvested. Age determined using SucheyBrooks method and compared with their chronological age. The aim of the study is to- 1. Determine the age of deceased from pubic symphysis using Suchey-Brooks method. 2. Compare the age determined by Suchey-Brooks method and chronological age and find the accuracy of Suchey-Brooks method in our population. MATERIALS AND METHODS Study Design- Descriptive study- Cross-sectional study, Centre of Study- Department of Forensic Medicine, Government Medical College, Kottayam, Study Sample- From the cases brought for medicolegal postmortem examination in the Department of Forensic Medicine, Government Medical College, Kottayam, Kerala, a sample of 316 cases were selected. To make the distribution among various age groups, even the total sample divided for the age group, which resulted in having 60 samples per age group. Age groups were considered as Group 1- Age between 18-25 years; Group 2- Age between 25-35 years; Group 3- Age between 35-45 years; Group 4- Age between 45-55 years; Group 5- Age between 55-65 years. Inclusion Criteria- 1. Cases with known age; 2. Cases whose age between 18 and 65 years. Exclusion Criteria- 1. Unknown cases; 2. Known cases with doubtful age; 3. Individuals having pubic bone trauma involving the

  5. Aging Trajectories in Different Body Systems Share Common Environmental Etiology : The Healthy Aging Twin Study (HATS)

    NARCIS (Netherlands)

    Moayyeri, Alireza; Hart, Deborah J.; Snieder, Harold; Hammond, Christopher J.; Spector, Timothy D.; Steves, Claire J.

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal

  6. Learning at old age: a study on winter bees

    Directory of Open Access Journals (Sweden)

    Andreas Behrends

    2010-04-01

    Full Text Available Ageing is often accompanied by a decline in learning and memory abilities across the animal kingdom. Understanding age-related changes in cognitive abilities is therefore a major goal of current research. The honey bee is emerging as a novel model organism for age-related changes in brain function, because learning and memory can easily be studied in bees under controlled laboratory conditions. In addition, genetically similar workers naturally display life expectancies from six weeks (summer bees to six months (winter bees. We studied whether in honey bees, extreme longevity leads to a decline in cognitive functions. Six-month-old winter bees were conditioned either to odours or to tactile stimuli. Afterwards, long-term memory and discrimination abilities were analysed. Winter bees were kept under different conditions (flight /no flight opportunity to test for effects of foraging activity on learning performance. Despite their extreme age, winter bees did not display an age-related decline in learning or discrimination abilities, but had a slightly impaired olfactory long-term memory. The opportunity to forage indoors led to a slight decrease in learning performance. This suggests that in honey bees, unlike in most other animals, age per se does not impair associative learning. Future research will show which mechanisms protect winter bees from age-related deficits in learning.

  7. Proteomic study on gender differences in aging kidney of mice

    Directory of Open Access Journals (Sweden)

    Cristobal Susana

    2009-04-01

    Full Text Available Abstract Background This study aims to analyze sex differences in mice aging kidney. We applied a proteomic technique based on subfractionation, and liquid chromatography coupled with 2-DE. Samples from male and female CD1-Swiss outbred mice from 28 weeks, 52 weeks, and 76 weeks were analysed by 2-DE, and selected proteins were identified by matrix assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS. Results This proteomic analysis detected age-related changes in protein expression in 55 protein-spots, corresponding to 22 spots in males and 33 spots in females. We found a protein expression signature (PES of aging composed by 8 spots, common for both genders. The identified proteins indicated increases in oxidative and proteolytic proteins and decreases in glycolytic proteins, and antioxidant enzymes. Conclusion Our results provide insights into the gender differences associated to the decline of kidney function in aging. Thus, we show that proteomics can provide valuable information on age-related changes in expression levels of proteins and related modifications. This pilot study is still far from providing candidates for aging-biomarkers. However, we suggest that the analysis of these proteins could suggest mechanisms of cellular aging in kidney, and improve the kidney selection for transplantation.

  8. Progression of aging in Mexico: the Mexican Health and Aging Study (MHAS) 2012

    Science.gov (United States)

    Wong, Rebeca; Michaels-Obregón, Alejandra; Palloni, Alberto; Gutiérrez-Robledo, Luis Miguel; González-González, César; López-Ortega, Mariana; Téllez-Rojo, Martha María; Mendoza-Alvarado, Laura Rosario

    2015-01-01

    Objective To describe the third wave of the Mexican Health and Aging Study (MHAS), completed in 2012, and present preliminary results. Materials and methods Descriptive analyses by gender and age group of demographic and socioeconomic characteristics, health conditions and health behaviors, as well as social support and life satisfaction measures are presented. In addition, external validations are presented by comparing MHAS 2012 indicators with other national data sources. Results For the panel of older adults in the sample, the rate of health care insurance coverage increased greatly between 2001 and 2012, a significantly higher change in rural compared to urban areas. The results for 2012 are consistent with the previous two waves for the main indicators of health and physical disability prevalence, risk factors, and behaviors. Conclusions The MHAS offers a unique opportunity to study aging in Mexico, as well as to complete cross-national comparisons. The cumulative number of deaths in the cohort should support the study of mortality and its association with health outcomes and behaviors over the life cycle. In addition, the sub-samples of objective markers will enable methodological research on self-reports and associations of biomarkers in old age with similar health outcomes and behaviors. PMID:26172238

  9. Aging properties studies in a Cu-Ag-Cr Alloy

    International Nuclear Information System (INIS)

    Jia, S.G.; Zheng, M.S.; Liu, P.; Ren, F.Z.; Tian, B.H.; Zhou, G.S.; Lou, H.F.

    2006-01-01

    A Cu-Ag-Cr alloy was produced by means of vacuum induction melting. The effects of aging processes on microhardness and conductivity of Cu-Ag-Cr alloy were studied. The microstructure of the alloy was examined using transmission electron microscope (TEM). Aging at 450 deg. C for 4 h, the alloy has an excellent combination of microhardness and conductivity, the microhardness and conductivity reach 132 HV and 80% IACS, respectively. The precipitates responsible for the age-hardening effect are fcc Cr. The fine and dispersed precipitates are fully coherent with the Cu matrix and make the Cu-Ag-Cr alloy possesses higher hardness and conductivity

  10. Social mobility and inflammatory and metabolic markers at older ages: the English Longitudinal Study of Ageing.

    Science.gov (United States)

    Na-Ek, Nat; Demakakos, Panayotes

    2017-03-01

    Since our knowledge of the associations between socioeconomic position (SEP) over the life course and inflammatory and metabolic markers, which are excellent predictors of cardiovascular disease, remains limited, we examined the association between social mobility over the life course and these markers at older ages. Our study used cross-sectionally collected data from 6142 participants aged 50 years and older from the English Longitudinal Study of Ageing. We estimated linear and logistic models of the associations between social mobility, using information on childhood and adult SEP, C reactive protein (CRP), fibrinogen, glycated haemoglobin (HbA1c) and high-density lipoprotein (HDL) cholesterol. Our models were gradually adjusted for age, sex, chronic diseases, obesity, physical activity, alcohol consumption, smoking status and depressive symptoms. Participants who experienced upward social mobility had higher CRP, fibrinogen and HbA1c levels compared with those who had stable high SEP over the life course, but lower compared with those who experienced downward social mobility or had stable low SEP. They also had lower HDL levels compared with those who had stable high SEP or downwardly mobile. Adjustment for covariates partially explained the associations between social mobility and CRP and HDL, and fully explained those between social mobility and fibrinogen and HbA1c. Social mobility is associated with inflammatory and metabolic markers at older ages with some of the observed associations persisting after accounting for covariates. Upward social mobility appears to partially reverse the damaging effect of childhood social disadvantage on inflammatory profiles in older ages. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  11. Roentgen study of bone age in obese children

    International Nuclear Information System (INIS)

    Baldzhijski, A.; Totsev, N.; Petrova, Ch.

    1991-01-01

    The study included 100 children (50 boys and 50 girls) aged from 1 to 18 years with different degree of obesity, classified according to the scheme of Knyazev et al. The bone age was determined by a X-ray method including conventional X-ray study of the left hand at standard conditions. The H. Thiemann - I. Nittz Atlass (1986) was used as a test. It was established that the children with overweight had a change in the bone age which in most cases outstriped the calendar one. It was stated that the determination of the index 'bone age' remained to be a reliable method for studing the obesity effect on the growth and developing of the children' organism. 2 figs., 2 tabs., 12 refs

  12. Profile and determinants of successful aging in the Ibadan Study of Ageing.

    Science.gov (United States)

    Gureje, Oye; Oladeji, Bibilola D; Abiona, Taiwo; Chatterji, Somnath

    2014-05-01

    To determine the profile and determinants of successful aging in a developing country characterized by low life expectancy and where successful agers may represent a unique group. Community-based cohort study. Eight contiguous states in the Yoruba-speaking region of Nigeria. A multistage clustered sampling of households was used to select a representative sample of individuals (N = 2,149) aged 65 and older at baseline. Nine hundred thirty were successfully followed for an average of 64 months between August 2003 and December 2009. Lifestyle and behavioral factors were assessed at baseline. Successful aging, defined using each of three models (absence of chronic health conditions, functional independence, and satisfaction with life), was assessed at follow-up. Between 16% and 75% of respondents could be classified as successful agers using one of the three models while 7.5% could be so classified using a combination of all the models. Correlations between the three models were small, ranging from 0.08 to 0.15. Different features predicted their outcomes, suggesting that they represent relatively independent trajectories of aging. Whichever model was used, more men than women tended to be classified as aging successfully. Men who aged successfully, using a combination of all the three models, were more likely never to have smoked (adjusted odds ratio (aOR) = 4.7, 95% confidence interval (CI) = 1.55-14.46) and to report, at baseline, having contacts with friends (aOR = 4.2, 95% CI = 1.0-18.76) or participating in community activities (aOR = 16.0, 95% CI = 1.23-204.40). In women, there was a nonlinear trend for younger age at baseline to predict this outcome. Modifiable social and lifestyle factors predicted successful aging in this population, suggesting that health promotion targeting behavior change may lead to tangible benefits for health and well-being in old age. © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

  13. Aging study of boiling water reactor high pressure injection systems

    International Nuclear Information System (INIS)

    Conley, D.A.; Edson, J.L.; Fineman, C.F.

    1995-03-01

    The purpose of high pressure injection systems is to maintain an adequate coolant level in reactor pressure vessels, so that the fuel cladding temperature does not exceed 1,200 degrees C (2,200 degrees F), and to permit plant shutdown during a variety of design basis loss-of-coolant accidents. This report presents the results of a study on aging performed for high pressure injection systems of boiling water reactor plants in the United States. The purpose of the study was to identify and evaluate the effects of aging and the effectiveness of testing and maintenance in detecting and mitigating aging degradation. Guidelines from the United States Nuclear Regulatory Commission's Nuclear Plant Aging Research Program were used in performing the aging study. Review and analysis of the failures reported in databases such as Nuclear Power Experience, Licensee Event Reports, and the Nuclear Plant Reliability Data System, along with plant-specific maintenance records databases, are included in this report to provide the information required to identify aging stressors, failure modes, and failure causes. Several probabilistic risk assessments were reviewed to identify risk-significant components in high pressure injection systems. Testing, maintenance, specific safety issues, and codes and standards are also discussed

  14. SCI Longitudinal Aging Study: 40 Years of Research.

    Science.gov (United States)

    Krause, James S; Clark, Jillian M R; Saunders, Lee L

    2015-01-01

    The Spinal Cord Injury (SCI) Longitudinal Aging Study was initiated in 1973 and has conducted 8 assessments over the past 40 years. It was designed to help rehabilitation professionals understand the life situation of people with SCI, but it has developed into the most long-standing study of aging and SCI and has resulted in over 50 publications. Our purpose was to provide a detailed history of the study, response patterns, utilization of measures, and a summary of key findings reported in the literature. Five participant samples have been incorporated over the 40 years, with enrollment in 1973, 1984, 1993 (2 samples), and 2003. A total of 2,208 participants have completed 6,001 assessments, with a particularly large number of assessments among those who are more than 40 years post injury (n = 349). The overall results have indicated changing patterns of outcomes over time as persons with SCI age, with some notable declines in participation and health. There has been a survivor effect whereby persons who are more active, well-adjusted, and healthier live longer. This study has several important features that are required for longitudinal research including (a) consistency of follow-up, (b) consistency of measures over time, (c) addition of new participant samples to counteract attrition, and (d) inclusion of a large number of individuals who have reached aging milestones unparalleled in the literature. Data from this study can inform the literature on the natural course of aging with SCI.

  15. Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study.

    Science.gov (United States)

    Schnack, Hugo G; van Haren, Neeltje E M; Nieuwenhuis, Mireille; Hulshoff Pol, Hilleke E; Cahn, Wiepke; Kahn, René S

    2016-06-01

    Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used support vector regression, a supervised machine learning technique, to address this question. In a longitudinal sample of 341 schizophrenia patients and 386 healthy subjects with one or more structural MRI scans (1,197 in total), machine learning algorithms were used to build models to predict the age of the brain and the presence of schizophrenia ("schizophrenia score"), based on the gray matter density maps. Age at baseline ranged from 16 to 67 years, and follow-up scans were acquired between 1 and 13 years after the baseline scan. Differences between brain age and chronological age ("brain age gap") and between schizophrenia score and healthy reference score ("schizophrenia gap") were calculated. Accelerated brain aging was calculated from changes in brain age gap between two consecutive measurements. The age prediction model was validated in an independent sample. In schizophrenia patients, brain age was significantly greater than chronological age at baseline (+3.36 years) and progressively increased during follow-up (+1.24 years in addition to the baseline gap). The acceleration of brain aging was not constant: it decreased from 2.5 years/year just after illness onset to about the normal rate (1 year/year) approximately 5 years after illness onset. The schizophrenia gap also increased during follow-up, but more pronounced variability in brain abnormalities at follow-up rendered this increase nonsignificant. The progressive brain loss in schizophrenia appears to reflect two different processes: one relatively homogeneous, reflecting accelerated aging of the brain and related to various measures of outcome, and a more variable one, possibly reflecting individual variation and

  16. MRI study of the brain in aged volunteers

    International Nuclear Information System (INIS)

    Kasahara, Hiroo; Tanno, Munehiko; Yamada, Hideo; Endoh, Kazuo; Kobayashi, Mitsuru; Karasawa, Akihide.

    1993-01-01

    In order to characterize age-related and chronological changes of the brain, longitudinal studies of aged volunteers were conducted using computed tomography since 1982. The present paper discusses correlations between brain function and findings of MR images which were obtained using a 1.5 T superconductive MR instrument since 1989. A total of 118 volunteers aged 60 to 88 years old with a mean age of 75.0±6.7 participated in the study, which consisted of MRI, EEG recording, the Benton Visual Retention Test and a medical interview. Subjects with a past history or clinical evidence of CVD, head trauma or dementia were excluded from the study. Incidence of T 2 high signal intensity lesions increased with age. Some showing T 1 low signal intensity in the same lesion were considered to be lacunar infarction, over all incidence of which was 24.6%. Numbers of correct responses on the BVRT showed a negative correlation with numbers of T 2 high signal intensity lesions. Although the aged volunteers in the present study could achieve all activity of daily living without any trouble, high cortical function evaluated by visuoperceptual performance of BVRT was somewhat disturbed in participants with multiple T 2 high signal intensity lesions. Brain atrophy seems to be more advanced in groups with T 2 hyper intensity lesions than in the group without them. These findings may support the notion that T 2 high signal intensity lesions are not merely an index of aging but pathologic lesions accompanied with senescence, although further studies including clinico-pathological correlation are necessary to establish this concept. (author)

  17. Age estimation using exfoliative cytology and radiovisiography: A comparative study.

    Science.gov (United States)

    Nallamala, Shilpa; Guttikonda, Venkateswara Rao; Manchikatla, Praveen Kumar; Taneeru, Sravya

    2017-01-01

    Age estimation is one of the essential factors in establishing the identity of an individual. Among various methods, exfoliative cytology (EC) is a unique, noninvasive technique, involving simple, and pain-free collection of intact cells from the oral cavity for microscopic examination. The study was undertaken with an aim to estimate the age of an individual from the average cell size of their buccal smears calculated using image analysis morphometric software and the pulp-tooth area ratio in mandibular canine of the same individual using radiovisiography (RVG). Buccal smears were collected from 100 apparently healthy individuals. After fixation in 95% alcohol, the smears were stained using Papanicolaou stain. The average cell size was measured using image analysis software (Image-Pro Insight 8.0). The RVG images of mandibular canines were obtained, pulp and tooth areas were traced using AutoCAD 2010 software, and area ratio was calculated. The estimated age was then calculated using regression analysis. The paired t -test between chronological age and estimated age by cell size and pulp-tooth area ratio was statistically nonsignificant ( P > 0.05). In the present study, age estimated by pulp-tooth area ratio and EC yielded good results.

  18. Study of ageing side effects in the DELPHI HPC calorimeter

    CERN Document Server

    Bonivento, W

    1997-01-01

    The readout proportional chambers of the HPC electromagnetic calorimeter in the DELPHI experiment are affected by large ageing. In order to study the long-term behaviour fo the calorimeter, one HPC module was extracted from DELPHI in 1992 and was brought to a test area where it was artificially aged during a period of two years; an ageing level exceeding the one expected for the HPC at the end of the LEP era was reached. During this period the performance of the module was periodically tested by means of dedicated beam tests whose results are discussed in this paper. These show that ageing has no significant effects on the response linearity and on the energy resolution for electromagnetic showers, once the analog response loss is compensated for by increasing the chamber gain through the anode voltage.

  19. RECRUITING OLDER VOLUNTEERS: FINDINGS FROM THE BELGIAN AGEING STUDIES

    Directory of Open Access Journals (Sweden)

    Sarah DURY

    2010-01-01

    Full Text Available Although there is a significant body of work concerning voluntary work, hardly any attention is given to volunteering of older individuals. Moreover, the potential volunteers among older adults is even less examined. Next to volunteering among olde r adults, the neighbou rhood becomes more salient when people age and this due to their more intense use and time spent in the neighbourhood. In response to these lacunae, the main purpose of this contribution is to examine the impact of subjective neighbourhood features on the recruitment potential for volunteering among older people. This study uses data collected from the Belgian Ageing Studies. 59.977 adults aged sixty and over living self-reliantly in 127 Flemish municipalities in Belgium participated in this study. A binary logistic regression is ap plied to analyse the key va riables characterizing potential volunteers. Our findings stress the need for recognizing the crucial importance of the locality when recruiting older adults for volunteer activities.

  20. Audiometric changes with age in Hiroshima: a statistical study

    Energy Technology Data Exchange (ETDEWEB)

    Hollingsworth, J W; Ishii, Goro

    1960-10-01

    Audiometry observations were analyzed for 290 irradiated survivors of the 1945 atomic bomb in Hiroshima and in 293 nonirradiated subjects. The study was undertaken in order to determine the age changes in audiology in irradiated and nonirradiated subjects as well as to investigate the pattern of hearing levels in a Japanese population for comparison with patterns in Caucasians. The following statistical observations were made. Correlation between hearing levels for right and left ear. Correlation between hearing levels at various cycles. Changes in hearing levels by age and sex. The relation between age and decibel loss was not linear and correlation ratios with age were 0.45 to 0.72. Audiometry seems to be of some value as one of a battery of tests of physiologic aging designed for detection of irradiation induced nonspecific aging acceleration. In this relatively small sample, no differences in hearing acuity were detected in the atomic bomb survivors as compared with the control sample. 6 references, 3 figures, 9 tables.

  1. Dental age estimation using Willems method: A digital orthopantomographic study

    Directory of Open Access Journals (Sweden)

    Rezwana Begum Mohammed

    2014-01-01

    Full Text Available In recent years, age estimation has become increasingly important in living people for a variety of reasons, including identifying criminal and legal responsibility, and for many other social events such as a birth certificate, marriage, beginning a job, joining the army, and retirement. Objectives: The aim of this study was to assess the developmental stages of left seven mandibular teeth for estimation of dental age (DA in different age groups and to evaluate the possible correlation between DA and chronological age (CA in South Indian population using Willems method. Materials and Methods: Digital Orthopantomogram of 332 subjects (166 males, 166 females who fit the study and the criteria were obtained. Assessment of mandibular teeth (from central incisor to the second molar on left quadrant development was undertaken and DA was assessed using Willems method. Results and Discussion: The present study showed a significant correlation between DA and CA in both males (r = 0.71 and females (r = 0.88. The overall mean difference between the estimated DA and CA for males was 0.69 ± 2.14 years (P 0.05. Willems method underestimated the mean age of males by 0.69 years and females by 0.08 years and showed that females mature earlier than males in selected population. The mean difference between DA and CA according to Willems method was 0.39 years and is statistically significant (P < 0.05. Conclusion: This study showed significant relation between DA and CA. Thus, digital radiographic assessment of mandibular teeth development can be used to generate mean DA using Willems method and also the estimated age range for an individual of unknown CA.

  2. The Estimation of Gestational Age at Birth in Database Studies.

    Science.gov (United States)

    Eberg, Maria; Platt, Robert W; Filion, Kristian B

    2017-11-01

    Studies on the safety of prenatal medication use require valid estimation of the pregnancy duration. However, gestational age is often incompletely recorded in administrative and clinical databases. Our objective was to compare different approaches to estimating the pregnancy duration. Using data from the Clinical Practice Research Datalink and Hospital Episode Statistics, we examined the following four approaches to estimating missing gestational age: (1) generalized estimating equations for longitudinal data; (2) multiple imputation; (3) estimation based on fetal birth weight and sex; and (4) conventional approaches that assigned a fixed value (39 weeks for all or 39 weeks for full term and 35 weeks for preterm). The gestational age recorded in Hospital Episode Statistics was considered the gold standard. We conducted a simulation study comparing the described approaches in terms of estimated bias and mean square error. A total of 25,929 infants from 22,774 mothers were included in our "gold standard" cohort. The smallest average absolute bias was observed for the generalized estimating equation that included birth weight, while the largest absolute bias occurred when assigning 39-week gestation to all those with missing values. The smallest mean square errors were detected with generalized estimating equations while multiple imputation had the highest mean square errors. The use of generalized estimating equations resulted in the most accurate estimation of missing gestational age when birth weight information was available. In the absence of birth weight, assignment of fixed gestational age based on term/preterm status may be the optimal approach.

  3. Aging studies on the first resistive-micromegas quadruplet @ GIF++

    CERN Document Server

    Alvarez Gonzalez, Barbara; The ATLAS collaboration

    2016-01-01

    Aging studies of the first resistive-micromegas quadruplet at GIF++: preliminary results A resistive-micromegas quadruplet built at CERN, serving as prototype of the ATLAS micromegas, has been installed at the new CERN Gamma Irradiation Facility (GIF++) with the aim of carrying out a long-term aging study. The detector has four active layers about 0.5 m2 each equipped with 1024 read-out strips and sputtered resistive layer for spark protection. It is exposed to an intense gamma irradiation (~50 MHz/cm2 provided by the 16.65 TBq 137Cs source of GIF++), corresponding to ~10 times more the expected counting rate at High-Luminosity LHC. Two smaller resistive bulk-micromegas produced at the CERN PCB workshop have also been installed at GIF++ in order to provide a comparison of the aging behavior with the micromegas quadruplet. We will give an overview of the aging properties of the resistive micromegas after few months of irradiation at GIF++. Detector aging evolution will be presented in terms of dark and amplifi...

  4. Accelerated optical polymer aging studies for LED luminaire applications

    Science.gov (United States)

    Estupiñán, Edgar; Wendling, Peter; Kostrun, Marijan; Garner, Richard

    2013-09-01

    There is a need in the lighting industry to design and implement accelerated aging methods that accurately simulate the aging process of LED luminaire components. In response to this need, we have built a flexible and reliable system to study the aging characteristics of optical polymer materials, and we have employed it to study a commercially available LED luminaire diffuser made of PMMA. The experimental system consists of a "Blue LED Emitter" and a working surface. Both the temperatures of the samples and the optical powers of the LEDs are appropriately characterized in the system. Several accelerated aging experiments are carried out at different temperatures and optical powers over a 90 hour period and the measured transmission values are used as inputs to a degradation model derived using plausibility arguments. This model seems capable of predicting the behavior of the material as a function of time, temperature and optical power. The model satisfactorily predicts the measured transmission values of diffusers aged in luminaires at two different times and thus can be used to make application recommendations for this material. Specifically, at 35000 hours (the manufacturer's stated life of the luminaire) and at the typical operational temperature of the diffuser, the model predicts a transmission loss of only a few percent over the original transmission of the material at 450 nm, which renders this material suitable for this application.

  5. Health and aging: development of the Irish Longitudinal Study on Ageing health assessment.

    Science.gov (United States)

    Cronin, Hilary; O'Regan, Clare; Finucane, Ciaran; Kearney, Patricia; Kenny, Rose Anne

    2013-05-01

    To assist researchers planning studies similar to The Irish Longitudinal Study on Ageing (TILDA), concerning the development of the health assessment component, to promote use of the archived data set, to inform researchers of the methods employed, and to complement the accompanying article on normative values. Prospective, longitudinal study of older adults. Republic of Ireland. Eight thousand five hundred four community-dwelling adults who participated in wave 1 of the TILDA study. The main areas of focus for the TILDA health assessments are neurocardiovascular instability, locomotion, and vision. The article describes the scientific rationale for the choice of assessments and seeks to determine the potential advantages of incorporating novel biomeasures and technologies in population-based studies to advance understanding of aging-related disorders. The detailed description of the physical measures will facilitate cross-national comparative research and put into context the normative values outlined in the subsequent article. © 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society.

  6. Accelerated brain aging in schizophrenia : A longitudinal pattern recognition study

    NARCIS (Netherlands)

    Schnack, Hugo G.; Van Haren, Neeltje E M; Nieuwenhuis, Mireille; Pol, Hilleke E Hulshoff; Cahn, Wiepke; Kahn, René S.

    2016-01-01

    OBJECTIVE: Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used

  7. Accelerated Brain Aging in Schizophrenia : A Longitudinal Pattern Recognition Study

    NARCIS (Netherlands)

    Schnack, Hugo G; van Haren, Neeltje E M; Nieuwenhuis, Mireille; Hulshoff Pol, Hilleke E; Cahn, Wiepke; Kahn, René S

    2016-01-01

    OBJECTIVE: Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used

  8. Study healthy ageing and intellectual disabilities : Recruitment and design

    NARCIS (Netherlands)

    Hilgenkamp, Thessa I. M.; Bastiaanse, Luc P.; Hermans, Heidi; Penning, Corine; van Wijck, Ruud; Evenhuis, Heleen M.

    2011-01-01

    Problems encountered in epidemiologic health research in older adults with intellectual disabilities (ID) are how to recruit a large-scale sample of participants and how to measure a range of health variables in such a group. This cross-sectional study into healthy ageing started with founding a

  9. studies on the reproductive status, catch and age compositions of ...

    African Journals Online (AJOL)

    ADMIN

    reproductive status of samples of Glossina pallidipes, trapped in NGU-2G traps. The objective was to assess ... male flies. Key words/phrases: Abortion, age reproductive status, Glossina pallidipes, NGU-2G traps, pregnancy. INTRODUCTION. From an ... ecology and behaviour of G. pallidipies. The present study was, ...

  10. A Taiwan Study Abroad Program on Aging, Culture, and Healthcare

    Science.gov (United States)

    Hou, Su-I

    2018-01-01

    This article introduces a Taiwan Study Abroad program on aging, culture, and healthcare. The program is a short-term academic summer program (6 credits) to bring U.S. students to Taiwan. During 2011 ~ 2015, a total of four groups including over 54 students and faculty members participated. This program partnered with multiple universities,…

  11. Studies of the Future Aged. An International Symposium.

    Science.gov (United States)

    Friis, Henning; Sheppard, Harold L., Ed.

    These six papers report on future-oriented studies of the situation of the elderly. "Changing Elderly in a Changing Society: Danish Elderly in the Next Century" (Henning Friis) reports on research dealing with preferences of the future elderly for their life when they grow older. "Aging Effectively: Meeting the Challenge of an Aging…

  12. Do hassles and uplifts change with age? Longitudinal findings from the VA normative aging study.

    Science.gov (United States)

    Aldwin, Carolyn M; Jeong, Yu-Jin; Igarashi, Heidi; Spiro, Avron

    2014-03-01

    To examine emotion regulation in later life, we contrasted the modified hedonic treadmill theory with developmental theories, using hassles and uplifts to assess emotion regulation in context. The sample was 1,315 men from the VA Normative Aging Study aged 53 to 85 years, who completed 3,894 observations between 1989 and 2004. We computed 3 scores for both hassles and uplifts: intensity (ratings reflecting appraisal processes), exposure (count), and summary (total) scores. Growth curves over age showed marked differences in trajectory patterns for intensity and exposure scores. Although exposure to hassles and uplifts decreased in later life, intensity scores increased. Group-based modeling showed individual differences in patterns of hassles and uplifts intensity and exposure, with relative stability in uplifts intensity, normative nonlinear changes in hassles intensity, and complex patterns of individual differences in exposure for both hassles and uplifts. Analyses with the summary scores showed that emotion regulation in later life is a function of both developmental change and contextual exposure, with different patterns emerging for hassles and uplifts. Thus, support was found for both hedonic treadmill and developmental change theories, reflecting different aspects of emotion regulation in late life. (c) 2014 APA, all rights reserved.

  13. Perspectives on healthy aging among Thai elderly: a qualitative study.

    Science.gov (United States)

    Thanakwang, Kattika; Soonthorndhada, Kusol; Mongkolprasoet, Jiraporn

    2012-12-01

    In this qualitative study, we provide an in-depth understanding of the views of healthy aging among Thai elderly and explore the ways that contribute to healthy aging. Data were collected using focus groups and in-depth interviews in four selected provinces of Thailand, and were analyzed using content analysis. The results revealed that Thai elderly described being healthy as the result of multiple components involving physical, mental, and social well-being. Healthy aging was viewed as an absence of serious diseases, having functional independence, a positive psycho-emotional outlook, and making a social contribution. The factors considered to contribute to healthy aging included activities promoting physical and psychological health, as well as active engagement in social activities. Understanding how the elderly define healthy aging and identifying the most important components and factors that contribute to being healthy provides insight into possible policy implications and interventions to promote health and well-being among Thai elderly. © 2012 Wiley Publishing Asia Pty Ltd.

  14. Clinical study on brain tumors in the aged

    International Nuclear Information System (INIS)

    Teramoto, Akira; Manaka, Shinya; Takakura, Kintomo

    1981-01-01

    In order to investigate the clinical features and the prognosis of brain tumors in the aged, 132 cases over 60 years of age were studied from the consecutive series of 1,793 brain tumors in the University of Tokyo Hospital (1963 - 1979). The incidence of brain tumors in the aged was 7.4% on the whole, while it showed a significant increase from 4.8% (1960's) to 11.5% (the later half of 1970's). Histologically, meningiomas were the most common tumors (26%), followed by neurinomas (17%), pituitary adenomas (16%) and metastatic tumors (15%). Malignant gliomas were found more frequently than benign ones. There were more meningiomas as age advanced. The proportion and the number of meningioma cases has obviously increased in recent years when CT scanners became available. Symptoms of intracranial hypertention were found less frequently in aged patients although they were still common in cases of glioblastomas. The duration from onset to surgery was relatively long, especially in cases of neurinomas and pituitary adenomas. Two cases of astrocytomas belonged to the category of silent gliomas. Overall operative mortality rate was 10.6%, while it showed a marked decrease to 4.7% in the 1970's. Five-year survival rates were as follows: meningiomas (58%), pituitary adenomas (70%), neurinomas (80%), glioblastomas (20%) and astrocytomas (25%). As for functional prognoses, 30% of the patients showed poor states on ADL, mostly because of residual psychic disorders. (author)

  15. Age and workers' perceptions of workplace safety: a comparative study.

    Science.gov (United States)

    Gyekye, Seth Ayim; Salminen, Simo

    2009-01-01

    The study examined the relationship between age and (i) safety perception; (ii) job satisfaction; (iii) compliance with safety management policies; and (iv) accident frequency. Participants were Ghanaian industrial workers (N=320) categorized into 4 age groups: 19-29 years; 30-39 years; 40-50 years; and 51 years and above. Workplace safety perception was assessed with Hayes, Perander, Smecko, and Trask's (1998) 50-item Work Safety Scale (WSS): a scale that effectively captures the dimensions identified by safety experts to influence perceptions of workplace safety. ANOVA was used to test for differences in the mean scores of the 4 groups. Post Hoc analysis revealed differences of statistical significance between the 2 younger cohorts and the 2 older cohorts. The results indicated a positive association between age and safety perception. Older workers had the best perceptions on safety, indicated the highest level of job satisfaction, were the most compliant with safety procedures, and recorded the lowest accident involvement rate. From a practical perspective, understanding age-related perceptions of workplace safety would benefit management's decisions regarding workers' adaptability, general work effectiveness, accident frequency, implementation of safety management policies, and handling of age-related accident characteristics.

  16. Multiproteinopathy, neurodegeneration and old age: a case study.

    Science.gov (United States)

    Rojas, Julio C; Stephens, Melanie L; Rabinovici, Gil D; Kramer, Joel H; Miller, Bruce L; Seeley, William W

    2018-02-01

    A complex spectrum of mixed brain pathologies is common in older people. This clinical pathologic conference case study illustrates the challenges of formulating clinicopathologic correlations in late-onset neurodegenerative diseases featuring cognitive-behavioral syndromes with underlying multiple proteinopathy. Studies on the co-existence and interactions of Alzheimer's disease (AD) with neurodegenerative non-AD pathologies in the aging brain are needed to understand the pathogenesis of neurodegeneration and to support the development of diagnostic biomarkers and therapies.

  17. Ferrocyanide safety project ferrocyanide aging studies FY 1995 annual report

    International Nuclear Information System (INIS)

    Lilga, M.A.; Alderson, E.V.; Hallen, R.T.

    1995-09-01

    This annual report gives the results of the work conducted by the Pacific Northwest Laboratory in FY 1995 on Task 3 of the Ferrocyanide Safety Project, Ferrocyanide Aging Studies. Aging refers to the dissolution and hydrolysis of simulated Hanford ferrocyanide waste in alkaline aqueous solutions by radiolytic and chemical means. The ferrocyanide simulant primarily used in these studies was dried In-Farm-1B, Rev. 7, prepared by Westinghouse Hanford Company to simulate the waste generated when the In-Farm flowsheet was used to remove radiocesium from waste supernates in single-shell tanks at the Hanford Site. In the In-Farm flowsheet, nickel ion and ferrocyanide anion were added to waste supernates to precipitate sodium nickel ferrocyanide, Na 2 NiFe(CN) 6 , and co-precipitate radiocesium. Once the radiocesium was removed, supernates were pumped from the tanks, and new wastes from cladding removal processes or from evaporators were added. These new wastes were typically highly caustic, having hydroxide ion concentrations of over 1 M and as high as 4 M. The Aging Studies task is investigating reactions this caustic waste may have had with the precipitated ferrocyanide waste in a radiation field. In previous Aging Studies research, Na 2 NiFe(CN) 6 in simulants was shown to dissolve in basic solutions, forming insoluble Ni(OH) 2 and soluble Na 4 Fe(CN) 6 . The influence on solubility of base strength, sodium ion concentration, anions, and temperature was previously investigated. The results may indicate that even ferrocyanide sludge that did not come into direct contact with highly basic wastes may also have aged significantly

  18. Positronium in metal-oxide powders studied with age. The age-momentum correlation technique

    International Nuclear Information System (INIS)

    Waeyenberge, B. van; Dauve, Ch.

    2001-01-01

    For the first time positronium is investigated in the fine powders of MgO and Al 2 O 3 using age-momentum correlation technique based on a relativistic positron beam. The application of this technique for investigating the interaction of positronium with the grain surfaces is discussed and compared with other techniques. The previously reported interaction of the positronium with paramagnetic centers is further studied. A qualitative interpretation of the spectra is given. In the Al 2 O 3 samples we found some unexpected behaviour of the conversion quenching of ortho-positronium at irradiation induced paramagnetic surface defect. (author)

  19. First Exploratory Study on the Ageing of Rammed Earth Material

    Science.gov (United States)

    Bui, Quoc-Bao; Morel, Jean-Claude

    2014-01-01

    Rammed earth (RE) is attracting renewed interest throughout the world thanks to its “green” characteristics in the context of sustainable building. In this study, the ageing effects on RE material are studied on the walls which have been constructed and exposed for 22 years to natural weathering. First, mechanical characteristics of the “old” walls were determined by two approaches: in-situ dynamic measurements on the walls; laboratory tests on specimens which had been cut from the walls. Then, the walls’ soil was recycled and reused for manufacturing of new specimens which represented the initial state. Comparison between the compressive strength, the Young modulus of the walls after 22 years on site and that of the initial state enables to assess the ageing of the studied walls. PMID:28787920

  20. Neuroimaging Studies Illustrate the Commonalities Between Ageing and Brain Diseases.

    Science.gov (United States)

    Cole, James H

    2018-07-01

    The lack of specificity in neuroimaging studies of neurological and psychiatric diseases suggests that these different diseases have more in common than is generally considered. Potentially, features that are secondary effects of different pathological processes may share common neurobiological underpinnings. Intriguingly, many of these mechanisms are also observed in studies of normal (i.e., non-pathological) brain ageing. Different brain diseases may be causing premature or accelerated ageing to the brain, an idea that is supported by a line of "brain ageing" research that combines neuroimaging data with machine learning analysis. In reviewing this field, I conclude that such observations could have important implications, suggesting that we should shift experimental paradigm: away from characterizing the average case-control brain differences resulting from a disease toward methods that place individuals in their age-appropriate context. This will also lead naturally to clinical applications, whereby neuroimaging can contribute to a personalized-medicine approach to improve brain health. © 2018 WILEY Periodicals, Inc.

  1. A correlative study of dental age and skeletal maturation.

    Science.gov (United States)

    Sachan, Kiran; Sharma, Vijay Prakash; Tandon, Pradeep

    2011-01-01

    Skeletal age had been assessed by comparison between maturation of hand-wrist with stages of cervical vertebrae or canine calcification stages in past and this had been closely related to craniofacial growth. The importance of pubertal growth spurt in various types of orthodontic therapies is already established. Hence, this study was aimed to evaluate the relationship of skeletal maturity by hand-wrist with cervical vertebral maturation indicators and canine calcification stages. The study consisted of randomly selected 90 children from Lucknow population with 45 males (age range 10-13 years) and 45 females (age range 9-12 years). Lateral Cephalogram, hand-wrist x-ray, and periapical x-rays of maxillary and mandibular right canines were taken. Mean, standard deviation was calculated of different groups. Correlation was made among cervical vertebral maturation, hand wrist maturation, and canine calcification stages at various age groups. There was strong correlation between skeletal maturation indicator and cervical vertebral maturation indicator for both male (0.849) and female (0.932), whereas correlation between skeletal maturation indicator and canine calcification was good for both male and female (0.635, 0.891). It was concluded that cervical vertebral maturation indicator and canine calcification stages can also be used for assessing skeletal maturity.

  2. MORPHOLOGICAL STUDY OF THE HUMAN OVARY IN DIFFERENT AGE GROUPS

    Directory of Open Access Journals (Sweden)

    Ritu Saloi

    2017-02-01

    Full Text Available BACKGROUND Ovarian pathology can manifest in various ways, e.g. menstrual abnormalities, cystic disease, infertility, benign and malignant tumours of the ovary, etc. Ovarian cancer is one of the leading cancers in Indian women. The aim was undertaken to observe the age-related changes in the human ovary and to study if there is any difference between the right and left ovaries with respect to length, breadth, thickness and weight and compare it with the established findings of previous workers, which will help the clinicians to adopt appropriate diagnosis and treatment of the various clinical conditions associated with the ovaries. MATERIALS AND METHODS A study on human ovary was conducted in the Department of Anatomy, Gauhati Medical College, Guwahati. The morphological characteristics of 42 pairs of normal human ovaries of different age groups were studied (14 pairs in each age group. The ovaries were divided into three groups, viz. Group A or pre-reproductive, Group B or reproductive and Group C or postmenopausal. The results were statistically analysed and ‘t’ test was done to find out the significant difference of mean value. RESULTS The morphology of the ovary including the length, breadth, thickness and weight of the three groups were measured and the findings were compared with each other and also with the findings of studies done by previous workers. CONCLUSION The study showed that there were certain differences in the morphology of ovary in the three groups. The study also revealed that the weight of the right ovary was more than the left ovary in all the three age groups. The results were statistically analysed and compared with the findings of previous workers.

  3. Study of dynamic strain aging in dual phase steel

    International Nuclear Information System (INIS)

    Queiroz, R.R.U.; Cunha, F.G.G.; Gonzalez, B.M.

    2012-01-01

    Highlights: ► Characterization of the high temperature mechanical behavior of a dual phase steel. ► Determination of the effect of dynamic strain aging on the strain hardening rate. ► Identification of the mechanism associated with dynamic strain aging. ► The value of the interaction energy carbon–dislocation in ferrite was confirmed. - Abstract: The susceptibility to dynamic strain aging of a dual phase steel was evaluated by the variation of mechanical properties in tension with the temperature and the strain rate. The tensile tests were performed at temperatures varying between 25 °C and 600 °C and at strain rates ranging from 10 −2 to 5 × 10 −4 s −1 . The studied steel presented typical manifestations related to dynamic strain aging: serrated flow (the Portevin–Le Chatelier effect) for certain combinations of temperature and strain rates; the presence of a plateau in the variation of yield stress with temperature; a maximum in the curves of tensile strength, flow stress, and work hardening exponent as a function of temperature; and a minimum in the variation of total elongation with temperature. The determined apparent activation energy values, associated with the beginning of the Portevin–Le Chatelier effect and the maximum in the variation of flow stress with temperature, were 83 kJ/mol and 156 kJ/mol, respectively. These values suggest that the mechanism responsible for dynamic strain aging in the dual phase steel is the locking of dislocations by carbon atoms in ferrite and that the formation of clusters and/or transition carbides and carbide precipitation in martensite do not interfere with the dynamic strain aging process.

  4. Twins for epigenetic studies of human aging and development

    DEFF Research Database (Denmark)

    Tan, Qihua; Christiansen, Lene; Thomassen, Mads

    2013-01-01

    Most of the complex traits including aging phenotypes are caused by the interaction between genome and environmental conditions and the interface of epigenetics may be a central mechanism. Although modern technologies allow us high-throughput profiling of epigenetic patterns already at genome level...... and environmental contributions to human diseases and complex traits. In the era of functional genomics, the valuable sample of twins is helping to bridge the gap between gene activity and the environments through epigenetic mechanisms unlimited by DNA sequence variations. We propose to extend the classical twin...... design to study the aging-related molecular epigenetic phenotypes and link them with environmental exposures especially early life events. Different study designs and application issues will be highlighted and novel approaches introduced with aim at making uses of twins in assessing the environmental...

  5. In-plant natural versus artificial aging study

    International Nuclear Information System (INIS)

    Shaw, M.

    1989-01-01

    A few years ago, cable specimens and small electrical components were placed in the reactor buildings of several operating nuclear plants in the United States. Temperature and radiation at the specimen locations are being monitored during the life of the plants. Measured physical properties of materials removed periodically during planned outages over the next 10 to 30 years will be compared with properties of artificially aged materials in identical specimens to assess artificial aging practice. This will also lead to improved lifetime predictions for cables and equipment. The study is being performed by the University of Connecticut's Institute for Materials Science in collaboration with U. S. utilities under the sponsorship of the Electric Power Research Institute (EPRI). Cofunding is being provided by Northeast Utilities and Detroit Edison. This paper gives the status of the study, along with some preliminary results

  6. Ageing studies with argon/methane based gas mixtures

    International Nuclear Information System (INIS)

    Silander, K.; De Lima, E.P.; Fraga, M.M.; Ferreira Marques, R.; Fraga, F.; Salete M.; Policarpo, A.J.P.L.; Leite, S.C.P.

    1995-01-01

    Ageing studies on a single wire proportional counter with Ar/CH 4 (90:10) (P10) and Ar/CH 4 /H 2 (89.5 : 10 : 0.5) (P10/H 2 ) mixtures irradiated with 6.4 keV X-ray photons from an X-ray generator, under well controlled conditions, are reported. For both mixtures, results are presented for the variation of the gain as a function of the accumulated charge per centimetre of the wire. The intensities of the main emissions (CI line at 193.1 nm and of the CH (A-X, B-X, C-X) molecular bands centred, respectively, at 431, 389 and 314 nm) are also measured. No ageing effects were observed up to an accumulated charge of 350 mC/cm with the P10/H 2 mixture. The tests performed with P10 following the P10/H 2 run, both for low and high irradiation rates, showed also negligible ageing, in contradiction with previous results. This may indicate that there is still some hydrogen adsorbed in the system that prevents the chamber from ageing. (orig.)

  7. Study clarifies associations between hypogonadism and health in aging men.

    Science.gov (United States)

    Amory, John K

    2012-11-01

    Tajar and colleagues present the associations between moderate and severe hypogonadism, symptoms of androgen deficiency and the prevelence of end-organ evidence of androgen deficency in 2966 older men in the European Male Aging Study. They find lower muscle mass, reduced bone mineral density, anemia, insulin resistence, metabolic syndrome and cardiovascular disease, with greater risks of these signs of androgen deficiency at lower serum testosterone concentrations.

  8. Cohort Differences in Cognitive Aging in the Longitudinal Aging Study Amsterdam.

    Science.gov (United States)

    Brailean, Anamaria; Huisman, Martijn; Prince, Martin; Prina, A Matthew; Deeg, Dorly J H; Comijs, Hannie

    2016-09-30

    This study aims to examine cohort differences in cognitive performance and rates of change in episodic memory, processing speed, inductive reasoning, and general cognitive performance and to investigate whether these cohort effects may be accounted for by education attainment. The first cohort (N = 705) was born between 1920 and 1930, whereas the second cohort (N = 646) was born between 1931 and 1941. Both birth cohorts were aged 65 to 75 years at baseline and were followed up 3 and 6 years later. Data were analyzed using linear mixed models. The later born cohort had better general cognitive performance, inductive reasoning, and processing speed at baseline, but cohort differences in inductive reasoning and general cognitive performance disappeared after adjusting for education. The later born cohort showed steeper decline in processing speed. Memory decline was steeper in the earlier born cohort but only from Time 1 to Time 3 when the same memory test was administered. Education did not account for cohort differences in cognitive decline. The later born cohort showed better initial performance in certain cognitive abilities, but no better preservation of cognitive abilities overtime compared with the earlier born cohort. These findings carry implications for healthy cognitive aging. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America.

  9. Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging.

    Science.gov (United States)

    Ericsson, Malin; Lundholm, Cecilia; Fors, Stefan; Dahl Aslan, Anna K; Zavala, Catalina; Reynolds, Chandra A; Pedersen, Nancy L

    2017-07-03

    In this report we analyzed genetically informative data to investigate within-person change and between-person differences in late-life cognitive abilities as a function of childhood social class. We used data from nine testing occasions spanning 28 y in the Swedish Adoption/Twin Study of Aging and parental social class based on the Swedish socioeconomic index. Cognitive ability included a general factor and the four domains of verbal, fluid, memory, and perceptual speed. Latent growth curve models of the longitudinal data tested whether level and change in cognitive performance differed as a function of childhood social class. Between-within twin-pair analyses were performed on twins reared apart to assess familial confounding. Childhood social class was significantly associated with mean-level cognitive performance at age 65 y, but not with rate of cognitive change. The association decreased in magnitude but remained significant after adjustments for level of education and the degree to which the rearing family was supportive toward education. A between-pair effect of childhood social class was significant in all cognitive domains, whereas within-pair estimates were attenuated, indicating genetic confounding. Thus, childhood social class is important for cognitive performance in adulthood on a population level, but the association is largely attributable to genetic influences.

  10. Proteomics and aging : studying the influence of aging on endothelial cells and human plasma

    NARCIS (Netherlands)

    Eman, M.R.

    2007-01-01

    In general, human aging is considered one of the most complex and less-well understood process in biology. In this thesis the possibilities of proteomics technology in the field of aging were explored. The complexity of the aging process was supposed to accompanied by relatively subtle proteome

  11. Morphological changes of the epiglottis with aging: A radiological study

    International Nuclear Information System (INIS)

    Jin, Bong Joon; Sim, Joong Seop; Yoon, Sei Chul; Ahn, Kwan Shik; Bahk, Yong Whee

    1983-01-01

    In man the epiglottis is a thin lamella of a yellow elastic cartilage. The upper part is free and is known as leaf and lower part participates in the formation of the anterior wall of the vestibule of the larynx. The ipithelial covering extends forward onto the base of the tongue over the medial glossoepiglottic folds. The sides of epiglottis are connected with the cartilages of Wrisberg and arytenoid cartilage by the aryepiglottic fold. In view of these anatomical complexities, the function and physiology of the epiglottis have been debated since Magendi (1815), who proposed the theory that the epiglottis acts as a flap valve to prevent food entering the windpipe, and who found that he could remove the free part of the epiglottis in dog without spoilling the dog. Following the introduction of laryngoscopy (Gracia, 1815; Liston, 1840; Czermark; 1861) and modern cineradiographic equipment in 1950's, the anatomy and physiology of epiglottis has become much clearer age as it is seen on the lateral x-ray of the neck. In the present study we have made an attempt to systematically analyze aging changes of the epiglottis in the lateral x-ray of the neck in 245 healthy adults. The age ranged from 16 to 65 years old. Based on our observation the epiglottis was classified into type A, B and C according to their curvatures. Thus, type A represented those with posterior curvature, type B those with straight epiglottis and type C anterior curvature. Type C was subdivided into I, II and III according to the degree of curvature. Thus, type C-I, C-II and C-III represented mild, moderate and marked anterior curvature, respectively. Type A epiglottis was found in the second, third and fourth decades and type C-III in the older age group. Type A was least common and type C most prevalent. It seems that the epiglottis inclines anteriorly with backward curvature with age (p<0.0001)

  12. A genome-wide association study of aging.

    Science.gov (United States)

    Walter, Stefan; Atzmon, Gil; Demerath, Ellen W; Garcia, Melissa E; Kaplan, Robert C; Kumari, Meena; Lunetta, Kathryn L; Milaneschi, Yuri; Tanaka, Toshiko; Tranah, Gregory J; Völker, Uwe; Yu, Lei; Arnold, Alice; Benjamin, Emelia J; Biffar, Reiner; Buchman, Aron S; Boerwinkle, Eric; Couper, David; De Jager, Philip L; Evans, Denis A; Harris, Tamara B; Hoffmann, Wolfgang; Hofman, Albert; Karasik, David; Kiel, Douglas P; Kocher, Thomas; Kuningas, Maris; Launer, Lenore J; Lohman, Kurt K; Lutsey, Pamela L; Mackenbach, Johan; Marciante, Kristin; Psaty, Bruce M; Reiman, Eric M; Rotter, Jerome I; Seshadri, Sudha; Shardell, Michelle D; Smith, Albert V; van Duijn, Cornelia; Walston, Jeremy; Zillikens, M Carola; Bandinelli, Stefania; Baumeister, Sebastian E; Bennett, David A; Ferrucci, Luigi; Gudnason, Vilmundur; Kivimaki, Mika; Liu, Yongmei; Murabito, Joanne M; Newman, Anne B; Tiemeier, Henning; Franceschini, Nora

    2011-11-01

    Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death. No single nucleotide polymorphism (SNP) was a genome-wide significant predictor of either outcome (p < 5 × 10(-8)). We found 14 independent SNPs that predicted risk of death, and 8 SNPs that predicted event-free survival (p < 10(-5)). These SNPs are in or near genes that are highly expressed in the brain (HECW2, HIP1, BIN2, GRIA1), genes involved in neural development and function (KCNQ4, LMO4, GRIA1, NETO1) and autophagy (ATG4C), and genes that are associated with risk of various diseases including cancer and Alzheimer's disease. In addition to considerable overlap between the traits, pathway and network analysis corroborated these findings. These findings indicate that variation in genes involved in neurological processes may be an important factor in regulating aging free of major disease and achieving longevity. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Ferrocyanide Safety Project: Subtask 3.4, Aging Studies

    International Nuclear Information System (INIS)

    Lilga, M.A.; Lumetta, M.R.; Riemath, W.F.; Romine, R.A.; Schiefelbein, G.F.

    1992-11-01

    The Hanford Ferrocyanide Task Team is addressing issues involving ferrocyanide precipitates in single-shell waste storage tanks (SSTs), in particular the storage of waste in a safe manner. This Task Team, composed of researchers from Westinghouse Hanford Company (WHC), Pacific Northwest Laboratory (PNL), and outside consultants, was formed in response to the need for an updated analysis of safety questions about the Hanford ferrocyanide tanks. This annual report gives the results of the work conducted by PNL in FY 1992 on Subtask 3.4, Aging Studies, which is part of Task 3, Chemical Nature of Feffocyanide in Wastes. Subtask 3.4 deals with the aging behavior and solubilization of ferrocyanide tank waste sludges in a basic aqueous environment. Investigated were the effects of pH variation, ionic strength, salts present in SSTS, and gamma radiation on solubilization of vendor-prepared Na 2 NiFe(CN) 6

  14. MORPHOLOGICAL STUDY OF THE AGE RELATED CHANGES OF THE CERVIX

    Directory of Open Access Journals (Sweden)

    Monjushree Chakravarty

    2016-07-01

    Full Text Available BACKGROUND Disease of the cervix is a common clinical condition in females, worldwide and especially in a developing country like India. The study was undertaken in Guwahati Medical College to see the age related changes in the morphology of the cervix. AIM The study was done to observe the age related changes in the cervix and compare the same with the different studies done by the previous workers around the world so as to help clinicians to diagnose the pathologies of this part of the female reproductive system better. MATERIALS AND METHOD The specimens were divided into three groups viz. pre-reproductive, reproductive and post-menopausal. Twenty specimens were collected of each group. The results were statistically analysed and ‘t’ test was employed to find out the significant difference between the mean value. SUMMARY A study of the 60 specimens collected were done to find the morphological parameters of each group viz. pre-reproductive, reproductive and post-menopausal and the findings of each group were compared to one another and were related to the finding of previous workers. CONCLUSION The study showed that there were certain differences in the morphology of the three groups and these differences tallied with that of the previous workers.

  15. Biochemical study on changes of artery with age

    International Nuclear Information System (INIS)

    Ito, Takanori

    1979-01-01

    The study was made in order to elucidate the aging phenomenon by focussing on the structural changes of elastin in aorta. Human thoracic aorta was separated in to three layers (intima, media and externa), and further intima was divided to three parts (normal, plaque and fatty streak part). Those parts were quantitatively determined on chemical substances, such as elastin, triglyceride, cholesterol, calcium and phosphorus. While experimental arteriosclerosis was made on rats with the load of cholesterol, and aorta of experimental rats were labeled with 45 CaCl 2 . Finally Ca ++ binding site on elastin was examined by, separating 45 Ca binding elastin from 45 Ca labeled aorta. Following results were obtained: 1) The elastin contents of human thoracic aorta decreased with age, especially in intima and fatty streak. 2) The cholesterol, calcium and phosphorus contents increased with age in, all layers of human thoracic aorta and remarkable decreases of them were observed in plaque and in fatty streak. 3) The elastin of fatty streak in human thoracic aorta was rich in aspartic acid, glutamic acid, serine and hydroxyproline compared with amino acid contents of that of normal part. 4) The 45 Ca binding peptide was separated from 45 Ca binding elastin extracted from experimentally induced arteriosclerosis by thin layer chromatography and it was characteristic peptide containing aspartic acid, glutamic acid, threonine, serine, glycine and alanine. This characteristic amino acid contents was in good agreement with increased amino acid contents in the elastin from fatty streak of human thoracic aorta. (author)

  16. Boiling-Water Reactor internals aging degradation study

    International Nuclear Information System (INIS)

    Luk, K.H.

    1993-09-01

    This report documents the results of an aging assessment study for boiling water reactor (BWR) internals. Major stressors for BWR internals are related to unsteady hydrodynamic forces generated by the primary coolant flow in the reactor vessel. Welding and cold-working, dissolved oxygen and impurities in the coolant, applied loads and exposures to fast neutron fluxes are other important stressors. Based on results of a component failure information survey, stress corrosion cracking (SCC) and fatigue are identified as the two major aging-related degradation mechanisms for BWR internals. Significant reported failures include SCC in jet-pump holddown beams, in-core neutron flux monitor dry tubes and core spray spargers. Fatigue failures were detected in feedwater spargers. The implementation of a plant Hydrogen Water Chemistry (HWC) program is considered as a promising method for controlling SCC problems in BWR. More operating data are needed to evaluate its effectiveness for internal components. Long-term fast neutron irradiation effects and high-cycle fatigue in a corrosive environment are uncertainty factors in the aging assessment process. BWR internals are examined by visual inspections and the method is access limited. The presence of a large water gap and an absence of ex-core neutron flux monitors may handicap the use of advanced inspection methods, such as neutron noise vibration measurements, for BWR

  17. Water hammer and its effect on ageing: an analytical study

    International Nuclear Information System (INIS)

    Kedia, Suruchi

    2006-01-01

    Water hammer can be disastrous from the point of view of ageing of the pipe(s)/Piping system. Design of restraints and protection devices for the various piping systems must consider severe stresses that may generate because of fluid transients. These fluid transients are termed as water hammer when it is restricted to water. But to have limited margins on the stress loads of piping system it is very important to predict the actual dimensions of the stresses. This paper covers various causes and analyses of the situations under which water hammer waves get generated and also way(s) to have control on occurrences of such situations. Few case studies are also covered showing the results and graphs of the stress waves generated because of water hammer. Effort has also been made in the paper in the direction to find out the methodology to compute the ageing of the system because of water hammer waves. Further in this paper an attempt is made to show the systematic methodology towards the diagnosis of water hammer that can be treated as a foundation stone for the creation of water hammer diagnosis system. Active measures to minimize the water hammer intensity by influencing fluid dynamic conditions of the system will also be suggested. Finally the paper will present the ageing aspects because of the stresses that generate due to water hammer. (author)

  18. Rubidium-strontium and uranium-lead isotopic age studies

    International Nuclear Information System (INIS)

    Loveridge, W.D.

    1980-01-01

    Rubidium-strontium whole rock isochron ages and initial 87 Sr/ 86 Sr ratios and uranium-lead ages on zircon from suites of samples selected from localities across Canada are presented. Descriptions of the geological probelms and interpretations of the measured ages are included. Laboratory age determination methods and techniques are described or referenced. (auth)

  19. Intellectual functioning in old and very old age: cross-sectional results from the Berlin Aging Study.

    Science.gov (United States)

    Lindenberger, U; Baltes, P B

    1997-09-01

    This study documents age trends, interrelations, and correlates of intellectual abilities in old and very old age (70-103 years) from the Berlin Aging Study (N = 516). Fourteen tests were used to assess 5 abilities: reasoning, memory, and perceptual speed from the mechanic (broad fluid) domain and knowledge and fluency from the pragmatic (broad crystallized) domain. Intellectual abilities had negative linear age relations, with more pronounced age reductions in mechanic than in pragmatic abilities. Interrelations among intellectual abilities were highly positive and did not follow the mechanic-pragmatic distinction. Sociobiographical indicators were less closely linked to intellectual functioning than sensory-sensorimotor variables, which predicted 59% of the total reliable variance in general intelligence. Results suggest that aging-induced biological factors are a prominent source of individual differences in intelligence in old and very old age.

  20. A STUDY OF DACRYOCYSTITIS IN PAEDIATRIC AGE GROUP

    Directory of Open Access Journals (Sweden)

    Ravi Kumar

    2016-03-01

    Full Text Available BACKGROUND Dacryocystitis in infants is a serious complication of congenital, but seldom of acquired nasolacrimal duct obstructions. If conservative treatment fails, dacryocystorhinostomy (DCR appears to be effective. The indications, special clinical history and results will be reviewed. PATIENTS AND METHODS From January 2006 to December 2010, a total of 30 children prospectively were involved in the study (26 male, 4 female with persistent dacryocystitis (4 patients were treated surgically by DCR and were continuously documented. The patients ranged in age from 10 months to 14 years old (mean age 4.9 years. Included in our study were 16 children (12 male, 4 female with 4 surgically treated lacrimal ducts. RESULTS The cause of dacryocystitis was congenital obstruction in 13 children and trauma (maxillary fracture in 1 child, respectively. Of these, 2 children (15% had additional anomalies of the lacrimal system, 1 (7.6% systemic malformations and 8 out of the 30 children (26% had a family history of nasolacrimal duct obstruction. We found a functional success rate (with complete resolution of symptoms of 90% (27 out of 30 lacrimal ducts over follow-up periods ranging from 1 month to 4 years (average 1 years. 8 children probing were done and remaining 18 children were managed conservatively. CONCLUSION Patients with persistent dacryocystitis due to congenital nasolacrimal duct obstruction have a prevalence of further nasolacrimal abnormalities and a family history In the case of persistent dacryocystitis, DCR is indicated after the age of 1 year and has the same success rate in infants as in adults (90-95%.

  1. Advanced maternal age and risk perception: A qualitative study

    Science.gov (United States)

    2012-01-01

    Background Advanced maternal age (AMA) is associated with several adverse pregnancy outcomes, hence these pregnancies are considered to be “high risk.” A review of the empirical literature suggests that it is not clear how women of AMA evaluate their pregnancy risk. This study aimed to address this gap by exploring the risk perception of pregnant women of AMA. Methods A qualitative descriptive study was undertaken to obtain a rich and detailed source of explanatory data regarding perceived pregnancy risk of 15 women of AMA. The sample was recruited from a variety of settings in Winnipeg, Canada. In-depth interviews were conducted with nulliparous women aged 35 years or older, in their third trimester, and with singleton pregnancies. Interviews were recorded and transcribed verbatim, and content analysis was used to identify themes and categories. Results Four main themes emerged: definition of pregnancy risk, factors influencing risk perception, risk alleviation strategies, and risk communication with health professionals. Conclusions Several factors may influence women's perception of pregnancy risk including medical risk, psychological elements, characteristics of the risk, stage of pregnancy, and health care provider’s opinion. Understanding these influential factors may help health professionals who care for pregnant women of AMA to gain insight into their perspectives on pregnancy risk and improve the effectiveness of risk communication strategies with this group. PMID:22988825

  2. Lung function in type 2 diabetes: the Normative Aging Study.

    Science.gov (United States)

    Litonjua, Augusto A; Lazarus, Ross; Sparrow, David; Demolles, Debbie; Weiss, Scott T

    2005-12-01

    Cross-sectional studies have noted that subjects with diabetes have lower lung function than non-diabetic subjects. We conducted this analysis to determine whether diabetic subjects have different rates of lung function change compared with non-diabetic subjects. We conducted a nested case-control analysis in 352 men who developed diabetes and 352 non-diabetic subjects in a longitudinal observational study of aging in men. We assessed lung function among cases and controls at three time points: Time0, prior to meeting the definition of diabetes; Time1, the point when the definition of diabetes was met; and Time2, the most recent follow-up exam. Cases had lower forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) at all time points, even with adjustment for age, height, weight, and smoking. In multiple linear regression models adjusting for relevant covariates, there were no differences in rates of FEV1 or FVC change over time between cases and controls. Men who are predisposed to develop diabetes have decreased lung function many years prior to the diagnosis, compared with men who do not develop diabetes. This decrement in lung function remains after the development of diabetes. We postulate that mechanisms involved in the insulin resistant state contribute to the diminished lung function observed in our subjects.

  3. Whole grain intake: The Baltimore Longitudinal Study of Aging.

    Science.gov (United States)

    Maras, Janice E; Newby, P K; Bakun, Peter J; Ferrucci, Luigi; Tucker, Katherine L

    2009-02-01

    Our objective was to identify major dietary sources of whole grains and to describe the construction of a database of whole grain content of foods. Dietary information was collected with 7-d food records from men and women in the Baltimore Longitudinal Study of Aging, mean age 62.1 +/- 16.0 years, who participated in the dietary assessment portion of the study (n = 1516), and estimates of whole grain intake were obtained from a newly developed database. The Pyramid Servings database and 1994-1996 Continuing Survey of Food Intakes by Individuals (CSFII) recipe ingredients database were then used to calculate both servings and gram weights of whole grain intakes. Mean intakes of whole grains, refined grains, and total grains, as well as frequency of intake for major whole grain food groups and whole grain content for each group, were calculated. Top contributors of whole grains were ready-to-eat breakfast cereals (made with whole grain as well as bran), hot breakfast cereals (made with whole grain), multi-grain bread, and whole wheat bread. While more research is needed to better understand the benefits of whole grains, the development of research tools, including databases to accurately assess whole grain intake, is a critical step in completing such research.

  4. Coping with multimorbidity in old age – a qualitative study

    Directory of Open Access Journals (Sweden)

    Löffler Christin

    2012-05-01

    Full Text Available Abstract Background Comparatively few studies address the problems related to multimorbidity. This is surprising, since multimorbidity is a particular challenge for both general practitioners and patients. This study focuses on the latter, analyzing the way patients aged 65–85 cope with multimorbidity. Methods 19 narrative in-depth interviews with multimorbid patients were conducted. The data was analysed using grounded theory. Of the 19 interviewed patients 13 were female and 6 male. Mean age was 75 years. Participating patients showed a relatively homogeneous socio-economic status. Patients were recruited from the German city of Hamburg and the state of North Rhine-Westphalia. Results Despite suffering from multimorbidity, interviewees held positive attitudes towards life: At the social level, patients tried to preserve their autonomy to the most possible extent. At the emotional level, interviewees oscillated between anxiety and strength - having, however, a positive approach to life. At the practical level, patients aimed at keeping their diseases under control. The patients tended to be critical in regards to medication. Conclusions These findings might have implications for the treatment of multimorbid patients in primary care and further research: The generally presumed passivity of older individuals towards medical treatment, which can be found in literature, is not evident among our sample of older patients. In future, treatment of these patients might take their potential for pro-active cooperation more strongly into account than it is currently the case.

  5. Genome and Epigenome Editing in Mechanistic Studies of Human Aging and Aging-Related Disease.

    Science.gov (United States)

    Lau, Cia-Hin; Suh, Yousin

    2017-01-01

    The recent advent of genome and epigenome editing technologies has provided a new paradigm in which the landscape of the human genome and epigenome can be precisely manipulated in their native context. Genome and epigenome editing technologies can be applied to many aspects of aging research and offer the potential to develop novel therapeutics against age-related diseases. Here, we discuss the latest technological advances in the CRISPR-based genome and epigenome editing toolbox, and provide insight into how these synthetic biology tools could facilitate aging research by establishing in vitro cell and in vivo animal models to dissect genetic and epigenetic mechanisms underlying aging and age-related diseases. We discuss recent developments in the field with the aims to precisely modulate gene expression and dynamic epigenetic landscapes in a spatial and temporal manner in cellular and animal models, by complementing the CRISPR-based editing capability with conditional genetic manipulation tools including chemically inducible expression systems, optogenetics, logic gate genetic circuits, tissue-specific promoters, and the serotype-specific adeno-associated virus. We also discuss how the combined use of genome and epigenome editing tools permits investigators to uncover novel molecular pathways involved in the pathophysiology and etiology conferred by risk variants associated with aging and aging-related disease. A better understanding of the genetic and epigenetic regulatory mechanisms underlying human aging and age-related disease will significantly contribute to the developments of new therapeutic interventions for extending health span and life span, ultimately improving the quality of life in the elderly populations. © 2016 S. Karger AG, Basel.

  6. Provenance study of a Bronze Age sword from Giurgiu

    International Nuclear Information System (INIS)

    Olariu, Agata; Badica, T.; Popescu, I. V.; Alexandrescu, E.

    2000-01-01

    This work is a compositional study of a bronze sword recently discovered near Giurgiu using the method of charged particles induced X ray emission (PIXE). The sword is of it Reutlingen type dated in the period Bronze Age D - Hallstatt A1, around 1200 B. C. The knowledge of its composition could give supplementary information about the provenance of this sword by comparing with other copper-based alloy objects from Bronze Age. To obtain the composition of the sword we have applied the method PIXE at the Tandem accelerator of IFIN-HH Magurele. We have extracted 3 samples from the body of the sword: one sample from the tip of the sword and 2 samples from the hilt. The samples have been flattened by a hammer and introduced in the irradiation chamber of the PIXE spectrometer. The targets have been irradiated by a current of protons of 3 MeV and about 5 nA from the linear accelerator Tandem of the department. The detection of the characteristic X ray emission have been done by a GeHP detector. The acquisition of the X ray spectra has been done online on a PC with a MCA interface Canberra. The detection system gave a 190 eV resolution at 5.9 keV. In the frame of the experimental conditions the following elements have been observed: As, Co, Cr, Cu, Fe, Ni, Pb, Sn and Zn. In the table we present the results of the PIXE analysis of the Bronze Age sword from Giurgiu. The instrumentation errors have been less than 15%. The values of the elemental concentrations have been normalized to 100%. In order to have a comparative study of composition we considered also the composition of 7 swords of the same type and from the same period from regions from the south of Danube in Bulgaria, and 6 copper-based alloy objects from Spalnaca deposit, in Transylvania, dated also Bronze Age. The sword from Giurgiu has a composition closer to the Bulgarian swords for the elements: As, Co, Cu, Ni, Sn. The ratios Sn/Cu versus As/Cu for the sword from Giurgiu, Spalnaca-Transylvania objects and

  7. Chronic disease and independence in old age: A case study

    International Nuclear Information System (INIS)

    Reeves, Pauline J.

    2006-01-01

    This report uses case study methodology to examine the issue of long-term care of the elderly in the United Kingdom, including where that care should take place. The report will examine the difficulties inherent in maintaining independent living for the elderly (in particular the danger and cost of falls). The case study presented is that of an elderly female patient who had suffered from chronic rheumatoid arthritis for over 10 years. She was admitted to hospital several times from December 2003 to January 2004. The discussion of her case is set in the context of the sociology of ageing; long-term care of the elderly and the UK National Service Frameworks, of which standard six relates to falls in the elderly. The report will also consider the problems in deciding whether it is necessary to terminate independent living for an individual

  8. Holocaust survivors in old age: the Jerusalem Longitudinal Study.

    Science.gov (United States)

    Stessman, Jochanan; Stesssman, Jochanan; Cohen, Aaron; Hammerman-Rozenberg, Robert; Bursztyn, Michael; Azoulay, Daniel; Maaravi, Yoram; Jacobs, Jeremy M

    2008-03-01

    To examine the hypothesis that Holocaust exposure during young adulthood negatively affects physical aging, causing greater morbidity, faster deterioration in health parameters, and shorter survival. A longitudinal cohort study of the natural history of an age-homogenous representative sample born in 1920/21 and living in Jerusalem. Community-based home assessments. Four hundred fifty-eight subjects of European origin aged 70 at baseline and 77 at follow-up. Comprehensive assessment of physical, functional, and psychosocial domains; biographical history of concentration camp internment (Camp), exposure to Nazi occupation during World War II (Exposure), or lack thereof (Controls); and 7-year mortality data from the National Death Registry. Holocaust survivors of the Camp (n=93) and Exposure (n=129) groups were more likely than Controls (n=236) to be male and less educated and have less social support (P=.01), less physical activity (P=.03), greater difficulty in basic activities of daily living (P=.009), poorer self-rated health (P=.04), and greater usage of psychiatric medication (P=.008). No other differences in health parameters or physical illnesses were found. Holocaust survivors had similar rates of deterioration in health and illness parameters over the follow-up period, and 7-year mortality rates were identical. Proportional hazard models showed that being an elderly Holocaust survivor was not predictive of greater 7-year mortality. Fifty years after their Holocaust trauma, survivors still displayed significant psychosocial and functional impairment, although no evidence was found to support the hypothesis that the delayed effects of the trauma of the Holocaust negatively influence physical health, health trajectories, or mortality.

  9. Aging gracefully: a comparative study of Japanese and Malaysian women aged 65-75.

    Science.gov (United States)

    Kok, Jin Kuan; Yap, Yuet Ngor

    2014-12-01

    Longer lives and extended retirement have created a 'young old age' stage of life. How people spend their "young old age" has become increasingly important. This research aims to investigate the different ageing experiences of Japanese and Malaysian women and the activities they engaged in their "young old age". In-depth interviews were conducted to collect data and an adapted grounded theory approach was used for data analysis. Findings reveal many common characteristics for both groups of research participants. The emerging themes show that Japanese and Malaysian Chinese have different life missions evident in their daily activities, one passing on culture and the other passing on family values and life experience. They also differ in their choice of living arrangement (independent versus dependent/interdependent), attitudes to life (fighting versus accepting) and activities in which to engage (aesthetic pursuits versus family oriented activities). Copyright © 2014 Elsevier Inc. All rights reserved.

  10. AFSC/REFM: Bomb-produced age validation study

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish age validation with bomb-produced radiocarbon (14C) requires a known-age Delta14C reference chronology spanning the era of a marine increase in bomb-produced...

  11. Risk evaluations of aging: Procedures guide for an age-dependent PSA with emphasis on prioritization and sensitivity studies

    International Nuclear Information System (INIS)

    Vesely, W.E.

    1991-01-01

    Based on the previous work which has been performed in the project, a procedures guide is being developed for carrying out an age-dependent probabilistic safety assessment (PSA) for evaluating the core damage frequency with aging effects explicitly treated. A PSA is basically a Level 1 Probabilistic Risk Assessment (PRA). The emphasis of the guide is on prioritization and sensitivity studies. Focus is also on active components although consideration of aging effects in passive components is also treated. The guide is intended to become a NUREG/CR and is the first of three volumes which are being developed. The following topics with demonstrations and applications are described in the presentation: (1) the age-dependent PSA versus the standard PSA; (2) component reliability models used in an age-dependent PSA; (3) approaches for transforming a PSA into an age-dependent PSA; (4) application of an age-dependent PSA; (5) using a PSA to evaluate the risk effects from aging passive components; (6) evaluation of the risk importance of passive components; (7) prioritizations of aging contributors; (8) evaluations of test and maintenance effectiveness; and (9) sensitivity studies and uncertainty analyses of aging effects

  12. X-Ray Exam: Bone Age Study (For Parents)

    Science.gov (United States)

    ... Fitness Diseases & Conditions Infections Drugs & Alcohol School & Jobs Sports Expert Answers (Q&A) Staying Safe Videos for ... large numbers of other kids of the same gender and age. The bone age is measured ... on the X-ray. A difference between a child's bone age and his or ...

  13. STUDIES ON HUMAN FALLOPIAN TUBAL EPITHELIUM IN DIFFERENT AGE GROUPS

    Directory of Open Access Journals (Sweden)

    Jayasri

    2016-02-01

    Full Text Available BACKGROUND AND AIMS The “fallopian tubes” (oviducts or uterine tubes are long paired flexuous reproductive organ which transports ova, spermatozoa, zygotes, the pre-implantation morulae and blastocyst. It has major role during reproductive period, but it remains as if vestigial organ before puberty and after menopause. Due to increasing rate of tubal block and infertility, oviducts and their structures gaining importance and have become a subject of research in present days particularly epithelium. The aim of the study is to ascertain any histological difference of tubal epithelium in different age groups and the research work could be utilized for investigation and management of infertility. MATERIALS AND METHODS Seven samples of each group i.e., prereproductive, reproductive & postmenopausal were collected from fresh unembalmed human cadavers received in the department of Anatomy, FAA Medical College, Barpeta, Assam. The slides were prepared using the standard laboratory procedure. Under low and high power objectives the type of cells were observed and epithelial height was measured in the different segments. Stress was given for any significant difference of epithelial height between the different age groups. RESULTS Study revealed that among the groups within the same segment, epithelial height was recorded highest (33.57µm in reproductive group as against the lowest (22.91µm in post-menopausal group. Epithelial structures of the prereproductive and reproductive groups were significantly differed (p<0.01 from the postmenopausal group. CONCLUSIONS From the findings of the present study it can be concluded that: 1. In all the groups fallopian tubal epithelium is of simple columnar type and contains three types of cells. Cells are ciliated, secretory & peg (intercalary cells. 2. In all the groups same type of increasing trend of epithelial height from intramural segment to ampullary segment was recorded. 3. In intergroup comparison of

  14. Biosystems Study of the Molecular Networks Underlying Hippocampal Aging Progression and Anti-aging Treatment in Mice

    Directory of Open Access Journals (Sweden)

    Jiao Wang

    2017-12-01

    Full Text Available Aging progression is a process that an individual encounters as they become older, and usually results from a series of normal physiological changes over time. The hippocampus, which contributes to the loss of spatial and episodic memory and learning in older people, is closely related to the detrimental effects of aging at the morphological and molecular levels. However, age-related genetic changes in hippocampal molecular mechanisms are not yet well-established. To provide additional insight into the aging process, differentially-expressed genes of 3- versus 24- and 29-month old mice were re-analyzed. The results revealed that a large number of immune and inflammatory response-related genes were up-regulated in the aged hippocampus, and membrane receptor-associated genes were down-regulated. The down-regulation of transmembrane receptors may indicate the weaker perception of environmental exposure in older people, since many transmembrane proteins participate in signal transduction. In addition, molecular interaction analysis of the up-regulated immune genes indicated that the hub gene, Ywhae, may play essential roles in immune and inflammatory responses during aging progression, as well as during hippocampal development. Our biological experiments confirmed the conserved roles of Ywhae and its partners between human and mouse. Furthermore, comparison of microarray data between advanced-age mice treated with human umbilical cord blood plasma protein and the phosphate-buffered saline control showed that the genes that contribute to the revitalization of advanced-age mice are different from the genes induced by aging. These results implied that the revitalization of advanced-age mice is not a simple reverse process of normal aging progression. Our data assigned novel roles of genes during aging progression and provided further theoretic evidence for future studies exploring the underlying mechanisms of aging and anti-aging-related disease

  15. Aging studies for the ATLAS Transition Radiation Tracker (TRT)

    CERN Document Server

    Åkesson, T; Bondarenko, V; Capéans-Garrido, M; Catinaccio, A; Cwetanski, Peter; Danielsson, H; Dittus, F; Dolgoshein, B A; Dressnandt, N; Ebenstein, W L; Eerola, Paule Anna Mari; Farthouat, Philippe; Fedin, O; Froidevaux, D; Gavrilenko, I; Grichkevitch, Y; Gagnon, P; Hajduk, Z; Keener, P T; Kekelidze, G D; Konovalov, S; Kowalski, T; Kramarenko, V A; Laritchev, A; Lichard, P; Lundberg, B; Luehring, F C; Markina, I; Manara, A; McFarlane, K; Mitsou, V; Muraviev, S; Newcomer, F M; Ogren, H; Oh, S H; Olszowska, J; Peshekhonov, V D; Rembser, C; Romaniouk, A; Rhone, O; Rust, D R; Shchegelskii, V; Shmeleva, A; Smirnov, S; Smirnova, L N; Sosnovtsev, V V; Sutchkov, S; Tartarelli, F; Tikhomirov, V; Van Berg, R; Vassilieva, L; Wang, C; Williams, H H

    2003-01-01

    A summary of the aging and material validation studies carried out for the ATLAS Transition Radiation Tracker (TRT) is presented. Particular emphasis is put on the different phenomena observed in straw tubes operating with the chosen Xe/CF//4/CO//2 mixture. The most serious effects observed are silicon deposition on the anode wire and damage of the anode wire gold plating. Etching phenomena and active radical effects are also discussed. With a careful choice of all materials and components, and with good control of the water contamination in the active gas, the ATLAS TRT will operate reliably for 10 years at the LHC design luminosity. To demonstrate this fully, more work is still needed on the gas system purification elements, in particular to understand their interplay with the active species containing fluorine created in the avalanche process under irradiation.

  16. The ageing kidney: biochemical and morphological study after irradiation

    International Nuclear Information System (INIS)

    Franciolini, F.; Becciolini, A.; Torcini, G.; Lanini, A.

    1982-01-01

    The behaviour of some activities of the kidney was studied both in young-adult and in adult rats exposed to an 8-Gy dose of γ-rays and killed at various intervals after irradiation (both in the morning and in the evening). Brush border and lysosomal enzymes did not show marked differences among control rats of the same age even if adult animals showed levels of maltase, alkaline phosphatase and LAP activities higher than the young-adult group. Moreover, irradiation did not induce typical modifications of the same enzyme activities in young-adult and adult rats. Adult animals showed a reduction in the brush border enzyme activities at 120 hours after irradiation while, at the same interval, lysosomal activities underwent an increase both in young and in adult animals. (orig.) [de

  17. Shift work and cognitive aging: a longitudinal study.

    Science.gov (United States)

    Bokenberger, Kathleen; Ström, Peter; Dahl Aslan, Anna K; Åkerstedt, Torbjörn; Pedersen, Nancy L

    2017-09-01

    Objectives The few studies of shift work and late life cognitive functioning have yielded mixed findings. The aim of the present study is to estimate the association between shift-work experience and change in cognitive performance before and after retirement age among older adults who were gainfully employed. Methods Five hundred and ninety five participants with no dementia were followed up for a mean of 17.6 standard deviation (SD) 8.8 years from a Swedish population-based sample. Participants had self-reported information on any type of shift-work experience (ever/never) in 1984 and measures of cognitive performance (verbal, spatial, memory, processing speed, and general cognitive ability) from up to 9 waves of cognitive assessments during 1986-2012. Night work history (ever/never) from 1998-2002 was available from a subsample (N=320). Early adult cognitive test scores were available for 77 men. Results In latent growth curve modeling, there were no main effects of "any-type" or night shift work on the mean scores or rate of change in any of the cognitive domains. An interaction effect between any-type shift work and education on cognitive performance at retirement was noted. Lower-educated shift workers performed better on cognitive tests than lower-educated day workers at retirement. Sensitivity analyses, however, indicated that the interactions appeared to be driven by selection effects. Lower-educated day workers demonstrated poorer cognitive ability in early adulthood than lower-educated shift workers, who may have selected jobs entailing higher cognitive demand. Conclusion There was no difference in late-life cognitive aging between individuals with a history of working shifts compared to those who had typical day work schedules during midlife.

  18. Flow Reactor for studying Physicochemical and aging properties of SOA

    Science.gov (United States)

    Babar, Z. B.

    2016-12-01

    Secondary organic aerosols (SOA) have importance in environmental processes such as affecting earth's radiative balance and cloud formation processes. For studying SOA formation large scale environmental batch reactors and laboratory scale flow reactors have been used. In this study application of flow reactor to study physicochemical properties of SOA is also investigated after its characterization. The flow reactor is of cylindrical design (ID 15 cm x L 70 cm) equipped with UV lamps. It is coupled with various instruments such as scanning mobility particle sizer, NOx analyzer, ozone analyzer, VOC analyzer, hygrometer, and temperature sensors for gas and particle phase measurements. OH radicals were generated by custom build ozone generator and relative humidity. The following characterizations were performed: (1) residence time distribution (RTD) measurements, (2) RH and temperature control, (3) OH radical exposure range (atmospheric aging time), (4) gas phase oxidation of SOA precursors such as α-pinene by OH radical. The flow reactor yielded narrow RTDs. In particular, RH and temperature can be controlled effectively between 0-60% and 22-43oC, respectively. OH radical exposure ranges from 6.49x1010 to 3.68x1011 molecules/cm3s (0.49 to 4.91 days). Our initial efforts on OH radical generation using hydrogen peroxide and its quantification by using flourescenet technique will be also be presented.

  19. Attitudes Towards Ads and Age: A Study in Seniors

    Directory of Open Access Journals (Sweden)

    Marta M. Estrada

    2014-08-01

    Full Text Available Older adults make up one of the markets with the greatest potential in the future. It is essential that businesses take the diversity within this group into account, and perform segmentation in order to obtain a favorable attitude towards the ad. The potential for segmentation by chronological age has been called into question in recent years, with cognitive age emerging as the main alternative. This research aims to analyses the relationship between the variables of attitude towards the ad, attitude towards the brand and purchasing intention among older adults, noting the moderating effect of the joint use of chronological age and cognitive age on these items. 

  20. A longitudinal study of age-related changes in intraocular pressure: the Kangbuk Samsung Health Study.

    Science.gov (United States)

    Zhao, Di; Kim, Myung Hun; Pastor-Barriuso, Roberto; Chang, Yoosoo; Ryu, Seungho; Zhang, Yiyi; Rampal, Sanjay; Shin, Hocheol; Kim, Joon Mo; Friedman, David S; Guallar, Eliseo; Cho, Juhee

    2014-09-02

    To examine the longitudinal association between age and intraocular pressure (IOP) in a large sample of Korean men and women. We conducted a prospective cohort study of 274,064 young and middle-aged Korean adults with normal fundoscopic findings, following them from January 1, 2002, to February 28, 2010. Health exams were scheduled annually or biennially. At each visit, IOP was measured in both eyes using automated noncontact tonometers. The longitudinal change in IOP with age was evaluated using three-level mixed models for longitudinal paired-eye data, accounting for correlations between paired eyes and repeated measurements over time. In fully adjusted models, the average longitudinal change in IOP per 1-year increase in age was -0.065 mm Hg (95% confidence interval [CI] -0.068 to -0.063), with marked sex differences (P < 0.001). In men, the average annual IOP change was -0.093 mm Hg (95% CI -0.096 to -0.091) throughout follow-up. In women, the average annual IOP change was -0.006 mm Hg (95% CI -0.010 to -0.003), with a relatively flat association in the age range of 30 to 59 years and more marked annual decreases at younger and older ages. Intraocular pressure was inversely associated with age in a large cohort of Korean adults attending health-screening visits. For men, this inverse association was observed throughout the entire age range, while for women it was evident only in younger (<30 years of age) and older (≥60 years of age) women, with no association in women aged 30 to 59. Further research is needed to better understand the underlying mechanisms and to reconsider cutoffs for defining high IOP by age and sex groups in Asian populations. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

  1. Active Aging Policies between Individual Needs and Collective Goods. A Study of Active Aging Policies and Practices in Norway

    Directory of Open Access Journals (Sweden)

    Tove Midtsundstad

    2014-05-01

    Full Text Available A main objective of European governments is to reduce the number of early retirees, either by reforming pension systems or promoting active aging in working life. The importance of formulating a coherent personnel policy for all age groups is increasingly recognized by employers. However, there is still a lack of knowledge as how to strategically cope with an aging labor force. The aim of this article is to define and discuss a number of challenges arising from workplace-related active aging policies. We in particular discuss how an emphasis on economic incentives and gains (“senior goods” may give rise to unanticipated side effects for the employers as well as the employees. The article is based on results from two recent studies: one study examining six Norwegian municipalities with seemingly good practices in work-related old age policies, and another examining such policies in eight establishments in four different industries.

  2. Recent aging studies for the ATLAS transition radiation tracker

    CERN Document Server

    Capéans-Garrido, M; Anghinolfi, F; Arik, E; Baker, O K; Baron, S; Benjamin, D; Bertelsen, H; Bondarenko, V; Bychkov, V; Callahan, J; Cardiel-Sas, L; Catinaccio, A; Cetin, S A; Cwetanski, Peter; Dam, M; Danielsson, H; Dittus, F; Dologshein, B; Dressnandt, N; Driouichi, C; Ebenstein, W L; Eerola, Paule Anna Mari; Farthouat, Philippe; Fedin, O; Froidevaux, D; Gagnon, P; Grichkevitch, Y; Grigalashvili, N S; Hajduk, Z; Hansen, P; Kayumov, F; Keener, P T; Kekelidze, G D; Khristatchev, A; Konovalov, S; Koudine, L; Kovalenko, S; Kowalski, T; Kramarenko, V A; Krüger, K; Laritchev, A; Lichard, P; Luehring, F C; Lundberg, B; Maleev, V; Markina, I; McFarlane, K W; Mialkovski, V; Mindur, B; Mitsou, V A; Morozov, S; Munar, A; Muraviev, S; Nadtochy, A; Newcorner, F M; Ogren, H; Oh, S H; Olszowska, J; Passmore, S; Patritchev, S; Peshekhonov, V D; Petti, R; Price, M; Rembser, C; Rohne, O; Romaniouk, A; Rust, D R; Ryabov, Yu; Ryzhov, V; Shchegelskii, V; Seliverstov, D M; Shin, T; Shmeleva, A; Smirnov, S; Sosnovtsev, V V; Soutchkov, V; Spiridenkov, E; Szczygiel, R; Tikhomirov, V; Van Berg, R; Vassilakopoulos, V I; Vassilieva, L; Wang, C; Williams, H H; Zalite, A

    2004-01-01

    The transition radiation tracker (TRT) is one of the three subsystems of the inner detector of the ATLAS experiment. It is designed to operate for 10 yr at the LHC, with integrated charges of similar to 10 C/cm of wire and radiation doses of about 10 Mrad and 2 multiplied by 10**1**4 neutrons/cm**2. These doses translate into unprecedented ionization currents and integrated charges for a large-scale gaseous detector. This paper describes studies leading to the adoption of a new ionization gas regime for the ATLAS TRT. In this new regime, the primary gas mixture is 70%Xe-27%CO**2-3%O**2. It is planned to occasionally flush and operate the TRT detector with an Ar-based ternary mixture, containing a small percentage of CF**4, to remove, if needed, silicon pollution from the anode wires. This procedure has been validated in realistic conditions and would require a few days of dedicated operation. This paper covers both performance and aging studies with the new TRT gas mixture. 12 Refs.

  3. Ferrocyanide safety project ferrocyanide aging studies. Final report

    International Nuclear Information System (INIS)

    Lilga, M.A.; Hallen, R.T.; Alderson, E.V.

    1996-06-01

    This final report gives the results of the work conducted by Pacific Northwest National Laboratory (PNNL) from FY 1992 to FY 1996 on the Ferrocyanide Aging Studies, part of the Ferrocyanide Safety Project. The Ferrocyanide Safety Project was initiated as a result of concern raised about the safe storage of ferrocyanide waste intermixed with oxidants, such as nitrate and nitrite salts, in Hanford Site single-shell tanks (SSTs). In the laboratory, such mixtures can be made to undergo uncontrolled or explosive reactions by heating dry reagents to over 200 degrees C. In 1987, an Environmental Impact Statement (EIS), published by the U.S. Department of Energy (DOE), Final Environmental Impact Statement, Disposal of Hanford Defense High-Level Transuranic and Tank Waste, Hanford Site, Richland, Washington, included an environmental impact analysis of potential explosions involving ferrocyanide-nitrate mixtures. The EIS postulated that an explosion could occur during mechanical retrieval of saltcake or sludge from a ferrocyanide waste tank, and concluded that this worst-case accident could create enough energy to release radioactive material to the atmosphere through ventilation openings, exposing persons offsite to a short-term radiation dose of approximately 200 mrem. Later, in a separate study (1990), the General Accounting Office postulated a worst-case accident of one to two orders of magnitude greater than that postulated in the DOE EIS. The uncertainties regarding the safety envelope of the Hanford Site ferrocyanide waste tanks led to the declaration of the Ferrocyanide Unreviewed Safety Question (USQ) in October 1990

  4. Age, forgiveness, and meeting behavior: A multilevel study

    NARCIS (Netherlands)

    Schulte, E.-M.; Lehmann-Willenbrock, N.K.; Kauffeld, S.

    2013-01-01

    Purpose: This paper aims to examine the effects of age on counteractive team meeting behaviors (e.g. complaining). Forgiveness is included as a potential buffer against these behaviors. A multilevel model is developed to test individual and team level age effects. Design/methodology/approach: A

  5. Active Ageing and Active Citizenship in Liguria: A Case Study

    Science.gov (United States)

    Palumbo, Mauro

    2014-01-01

    Liguria has the oldest age structure in Europe because of a low birth rate and long lifespans and therefore is a very interesting laboratory region in which to experiment with active ageing policies. The generations that are now approaching retirement hold a high level of personal and professional resources; so the "new" elderly people…

  6. Age-Related Maculopathy: a biochemical and immunohistochemical study

    NARCIS (Netherlands)

    M. Kliffen (Mike)

    1996-01-01

    textabstractAge-related maculopathy (ARM) is an age-related degenerative disorder of the central part of the retina, the macula lutea (yellow spot). Essentially, ARM is a clinical diagnosis based on funduscopical changes. It is customary nowadays to call the late stages of ARM, geographic atrophy

  7. Aging driver and pedestrian safety : parking lot hazards study [summary].

    Science.gov (United States)

    2012-01-01

    In 2009, Florida reported the highest rate of pedestrian fatalities in the nation. At 2.51 deaths per 100,000 residents, Floridas rate was nearly twice the national average. These deaths occurred in all age groups, but compared to other age groups...

  8. DNA methylation age is associated with mortality in a longitudinal Danish twin study

    DEFF Research Database (Denmark)

    Christiansen, Lene; Lenart, Adam; Tan, Qihua

    2016-01-01

    included a 10-year longitudinal study of the 86 oldest-old twins (mean age of 86.1 at follow-up), which subsequently were followed for mortality for 8 years. We found that the DNAm age is highly correlated with chronological age across all age groups (r = 0.97), but that the rate of change of DNAm age...

  9. Practical problems of groundwater model ages for groundwater protection studies

    International Nuclear Information System (INIS)

    Matthess, G.; Muennich, K.O.; Sonntag, C.

    1976-01-01

    Water authorities in the Federal Republic of Germany have established a system of protection zones for the protection of groundwater supplies from pollution. One zone (Zone II) is defined by an outer boundary from which the groundwater needs 50 days to flow to the well. 50 days is the period accepted for the elimination of pathogenic germs. However, within Zone II carbon-14 measurements of water may give model ages of several thousand years, which may lead to some confusion in the legal and practical aspects of this scheme. These model ages may result from uncertainties in the chemical model, or from mixing of waters of different ages, either within the aquifer or during extraction at the well. The paper discusses scientific aspects of the establishment of protection zones. Two processes affecting the model age determinations are examined in detail. First, the mechanism of diffusion transport downwards through porous, but impermeable, aquicludes is examined for stable trace substances and radioactive isotopes. Secondly, examples are given of model ages resulting from mixtures of new and old waters. It is recommended that such model ages should not be reported as 'ages' since they may be misinterpreted in groundwater protection applications. (author)

  10. The Epidemiology of Social Isolation: National Health & Aging Trends Study.

    Science.gov (United States)

    Cudjoe, Thomas K M; Roth, David L; Szanton, Sarah L; Wolff, Jennifer L; Boyd, Cynthia M; Thorpe, Roland J

    2018-03-26

    Social isolation among older adults is an important but under-recognized risk for poor health outcomes. Methods are needed to identify subgroups of older adults at risk for social isolation. We constructed a typology of social isolation using data from the National Health and Aging Trends Study (NHATS) and estimated the prevalence and correlates of social isolation among community-dwelling older adults. The typology was formed from four domains: living arrangement, core discussion network size, religious attendance, and social participation. In 2011, 24% of self-responding, community-dwelling older adults (65+ years), approximately 7.7 million people, were characterized as socially isolated, including 1.3 million (4%) who were characterized as severely socially isolated. Multinomial multivariable logistic regression indicated that being unmarried, male, having low education, and low income were all independently associated with social isolation. Black and Hispanic older adults had lower odds of social isolation compared to White older adults, after adjusting for covariates. Social isolation is an important and potentially modifiable risk that affects a significant proportion of the older adult population.

  11. Organic tanks safety program FY95 waste aging studies

    International Nuclear Information System (INIS)

    Camaioni, D.M.; Samuels, W.D.; Clauss, S.A.; Lenihan, B.D.; Wahl, K.L.; Campbell, J.A.; Shaw, W.J.

    1995-09-01

    This report gives the second year's findings of a study of how thermal and radiological processes may change the composition of organic compounds in the underground tanks at Hanford. Efforts were focused on the global reaction kinetics in a simulated waste exposed to γ rays and the reactions of organic radicals with nitrite ion. The gas production is predominantly radiolytic. Decarboxylation of carboxylates is probably an aging pathway. TBP was totaly consumed in almost every run. Radiation clearly accelerated consumption of the other compounds. EDTA is more reactive than citrate. Oximes and possibly organic nitro compounds are key intermediates in the radiolytic redox reactions of organic compounds with nitrate/nitrite. Observations are consistent with organic compounds being progressively degraded to compounds with greater numbers of C-O bonds and fewer C-H and C-C bonds, resulting in an overall lower energy content. If the radwaste tanks are adequately ventilated and continually dosed by radioactivity, their total energy content should have declined. Level of risk depends on how rapidly carboxylate salts of moderate energy content (including EDTA fragments) degrade to low energy oxalate and formate

  12. Ageing tests study on wood-based sandwich panels

    Directory of Open Access Journals (Sweden)

    Mateo, Raquel

    2011-12-01

    Full Text Available Composite lightweight wood panels are being increasingly used in construction in Spain. Their growing use should be accompanied by necessary guarantees based on studies of their properties. As it is prescriptive and in addition to others tests, in the present work is examinated the durability of these panels when exposed to the climatic conditions, a characteristic of great importance for wood products, according to Guide ETAG 016, the current standard defining the ageing tests to be used. However, due to the use class of this material, there are indications that the testing outlined in this Guide is inappropriate for assessing the ageing of wood-based sandwich panels. Alternative tests are here proposed that recreate rather better the real conditions under which these products are used. Covering the samples in a waterproof sheeting permeable to the outward movement of water vapour, which is in fact used in the installation, provided the best procedure for testing these panels.

    Los paneles sándwich de madera son un producto de creciente aplicación en la edificación de nuestro país. Este ascendente uso del material debe estar acompañado de las garantías necesarias avaladas por un estudio previo de sus prestaciones. Como es preceptivo y entre otros, se evalúa su durabilidad frente a las condiciones climatológicas, clave en los productos derivados de la madera, acorde a la normativa actual definida con tal fin, la Guía ETAG 016. Sin embargo, debido a la clase de uso del material, se ha detectado que dicha normativa tal y como está concebida no es capaz de valorar su envejecimiento adecuadamente. En este trabajo se proponen ensayos alternativos al establecido tras exhaustivos análisis que recrean las condiciones reales de uso y más acordes a los productos de madera. Se concluye que la incorporación de una lámina impermeable pero permeable al vapor de agua hacia el exterior, como las utilizadas en el montaje, aportan el mejor

  13. Do levels of perceived stress increase with increasing age after age 65? A population-based study.

    Science.gov (United States)

    Osmanovic-Thunström, Almira; Mossello, Enrico; Åkerstedt, Torbjörn; Fratiglioni, Laura; Wang, Hui-Xin

    2015-09-01

    psychological and health-related stressors often occur in advanced ages, but little is known about perceived stress in adults aged 65 and over. This study aimed to test the hypothesis that levels of perceived stress increase with increasing age and to detect factors that may account for the association. a dementia-free cohort of 1,656 adults aged 66-97 years living at home or in institutions, participating in the Swedish National Aging and Care study, Kungsholmen (SNAC-K) was assessed for levels of perceived stress using the 10-item perceived stress scale (PSS). prevalence of high stress according to the top tertile of the population (PSS score 20+) was 7.8% in adults aged 81+ years, 7.5% in adults aged 72-78 and 6.2% in adults aged 66 years (P = 0.020). More women than men reported high stress, 8.3 versus 5.4% (P = 0.001). Levels of stress increased with increasing age (P = 0.001) in the linear regression model. This association remained after adjustment for demographic and psychosocial factors, but no longer was present after adjusting for health-related factors. health-related stress is highly prevalent in older adults and seems to play an important role in the association between levels of perceived stress and age in older adults. © The Author 2015. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Studies of Viking Age swords: metallography and archaeology

    Directory of Open Access Journals (Sweden)

    Elisabeth Astrup, Eva

    2011-12-01

    Full Text Available The paper is a comment on Alan Williams investigation ‘A Metallurgical Study of some Viking Swords’ published in Gladius XXIX. Williams’ paper comprise metallurgical investigations of 44 Viking Age Swords, all with ULFBERHT inscriptions. Such investigations, made by a well qualified metallurgist, are essential to archaeology. Unfortunately, this one has some serious limitations. In order to give a good description of the quality of a sword-blade, samples showing at least the section through both the edge and the central part of the blade are necessary. This is mostly not the case in Williams’ investigations, and he gives insufficient information about his samples. Other weak points are his group division and his interpretation of the production area for blades containing high-carbon steel.

    Este trabajo es un comentario sobre la investigación de Alan Williams ‘A Metallurgical Study of some Viking Swords` publicado en Gladius XXIX. El artículo de Williams incluye un estudio arqueometalúrgico de 44 espadas de época vikinga, todas ellas con la inscripción ULFBERHT. Estas investigaciones, realizadas por un arqueometalúrgico altamente cualificado, son esenciales en arqueología. Sin embargo, esta en concreto presenta algunas serias limitaciones. Para poder proporcionar una buena descripción de la calidad de la hoja de una espada, son necesarias muestras de al menos la sección desde el filo y hasta la parte central de la hoja. Este no es el caso de la mayoría de las muestras de Williams, quien proporciona insuficiente información sobre su toma de muestras. Otros puntos débiles son su clasificación en grupos y su interpretación del área de producción para las hojas que contienen un acero con elevado contenido de carbono.

  15. Quantitative analysis of the renal aging in rats. Stereological study

    OpenAIRE

    Melchioretto, Eduardo Felippe; Zeni, Marcelo; Veronez, Djanira Aparecida da Luz; Martins Filho, Eduardo Lopes; Fraga, Rogério de

    2016-01-01

    ABSTRACT PURPOSE: To evaluate the renal function and the renal histological alterations through the stereology and morphometrics in rats submitted to the natural process of aging. METHODS: Seventy two Wistar rats, divided in six groups. Each group was sacrificed in a different age: 3, 6, 9, 12, 18 and 24 months. It was performed right nephrectomy, stereological and morphometric analysis of the renal tissue (renal volume and weight, density of volume (Vv[glom]) and numerical density (Nv[glo...

  16. Chronic pain, perceived stress, and cellular aging: an exploratory study

    OpenAIRE

    Sibille, Kimberly T; Langaee, Taimour; Burkley, Ben; Gong, Yan; Glover, Toni L; King, Chris; Riley, Joseph L; Leeuwenburgh, Christiaan; Staud, Roland; Bradley, Laurence A; Fillingim, Roger B

    2012-01-01

    Abstract Background Chronic pain conditions are characterized by significant individual variability complicating the identification of pathophysiological markers. Leukocyte telomere length (TL), a measure of cellular aging, is associated with age-related disease onset, psychosocial stress, and health-related functional decline. Psychosocial stress has been associated with the onset of chronic pain and chronic pain is experienced as a physical and psychosocial stressor. However, the utility of...

  17. Age groups related glioblastoma study based on radiomics approach.

    Science.gov (United States)

    Li, Zeju; Wang, Yuanyuan; Yu, Jinhua; Guo, Yi; Zhang, Qi

    2017-12-01

    Glioblastoma is the most aggressive malignant brain tumor with poor prognosis. Radiomics is a newly emerging and promising technique to reveal the complex relationships between high-throughput medical image features and deep information of disease including pathology, biomarkers and genomics. An approach was developed to investigate the internal relationship between magnetic resonance imaging (MRI) features and the age-related origins of glioblastomas based on a quantitative radiomics method. A fully automatic image segmentation method was applied to segment the tumor regions from three dimensional MRI images. 555 features were then extracted from the image data. By analyzing large numbers of quantitative image features, some predictive and prognostic information could be obtained by the radiomics approach. 96 patients diagnosed with glioblastoma pathologically have been divided into two age groups (age groups (T test, p age difference (T test, p= .006). In conclusion, glioblastoma in different age groups present different radiomics-feature patterns with statistical significance, which indicates that glioblastoma in different age groups should have different pathologic, protein, or genic origins.

  18. The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond

    Directory of Open Access Journals (Sweden)

    Whalley Lawrence J

    2007-12-01

    Full Text Available Abstract Background Cognitive ageing is a major burden for society and a major influence in lowering people's independence and quality of life. It is the most feared aspect of ageing. There are large individual differences in age-related cognitive changes. Seeking the determinants of cognitive ageing is a research priority. A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age. Methods/Design The study is designed as a follow-up cohort study. The participants comprise surviving members of the Scottish Mental Survey of 1947 (SMS1947; N = 70,805 who reside in the Edinburgh area (Lothian of Scotland. The SMS1947 applied a valid test of general intelligence to all children born in 1936 and attending Scottish schools in June 1947. A total of 1091 participants make up the Lothian Birth Cohort 1936. They undertook: a medical interview and examination; physical fitness testing; extensive cognitive testing (reasoning, memory, speed of information processing, and executive function; personality, quality of life and other psycho-social questionnaires; and a food frequency questionnaire. They have taken the same mental ability test (the Moray House Test No. 12 at age 11 and age 70. They provided blood samples for DNA extraction and testing and other biomarker analyses. Here we describe the background and aims of the study, the recruitment procedures and details of numbers tested, and the details of all examinations. Discussion The principal strength of this cohort is the rarely captured phenotype of lifetime cognitive change. There is additional rich information to examine the determinants of individual differences in this lifetime cognitive change. This protocol report is important in alerting other researchers to the data available in the cohort.

  19. Analyzing age-specific genetic effects on human extreme age survival in cohort-based longitudinal studies

    DEFF Research Database (Denmark)

    Tan, Qihua; Jacobsen, Rune; Sørensen, Mette

    2013-01-01

    The analysis of age-specific genetic effects on human survival over extreme ages is confronted with a deceleration pattern in mortality that deviates from traditional survival models and sparse genetic data available. As human late life is a distinct phase of life history, exploring the genetic...... effects on extreme age survival can be of special interest to evolutionary biology and health science. We introduce a non-parametric survival analysis approach that combines population survival information with individual genotype data in assessing the genetic effects in cohort-based longitudinal studies...

  20. Dermatological disease in the older age group: a cross-sectional study in aged care facilities.

    Science.gov (United States)

    Deo, Maneka S; Kerse, Ngaire; Vandal, Alain C; Jarrett, Paul

    2015-12-23

    To estimate the prevalence of dermatological disease in aged care facilities, and the relationship between cognitive or physical disability and significant disease. 2 large aged care facilities in Auckland, New Zealand, each providing low and high level care. All 161 residents of the facilities were invited to participate. The only exclusion criterion was inability to obtain consent from the individual or designated guardian. 88 participants were recruited-66 females (75%), 22 males (25%) with average age 87.1 years (SD 5.5 years). Primary--presence of significant skin disease (defined as that which in the opinion of the investigators needed treatment or was identified as a patient concern) diagnosed clinically on full dermatological examination by a dermatologist or dermatology trainee. Secondary--functional and cognitive status (Rehabilitation Complexity Scale and Abbreviated Mental Test Score). 81.8% were found to have at least one significant condition. The most common disorders were onychomycosis 42 (47.7%), basal cell carcinoma 13 (14.8%), asteototic eczema 11 (12.5%) and squamous cell carcinoma in situ 9 (10.2%). Other findings were invasive squamous cell carcinoma 7 (8%), bullous pemphigoid 2 (2.3%), melanoma 2 (2.3%), lichen sclerosus 2 (2.3%) and carcinoma of the breast 1 (1.1%). Inflammatory disease was more common in those with little physical disability compared with those with serious physical disability (OR 3.69; 95% CI 1.1 to 12.6, p=0.04). No significant association was found between skin disease and cognitive impairment. A high rate of dermatological disease was found. Findings ranged from frequent but not life-threatening conditions (eg, onychomycosis), to those associated with a significant morbidity (eg, eczema, lichen sclerosus and bullous pemphigoid), to potentially life-threatening (eg, squamous cell carcinoma, melanoma and breast cancer). Those with less significant physical impairment were found to be at greater risk of inflammatory

  1. Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging.

    Science.gov (United States)

    Petrini, Stefania; Borghi, Rossella; D'Oria, Valentina; Restaldi, Fabrizia; Moreno, Sandra; Novelli, Antonio; Bertini, Enrico; Compagnucci, Claudia

    2017-05-31

    Nuclear integrity and mechanical stability of the nuclear envelope (NE) are conferred by the nuclear lamina, a meshwork of intermediate filaments composed of A- and B-type lamins, supporting the inner nuclear membrane and playing a pivotal role in chromatin organization and epigenetic regulation. During cell senescence, nuclear alterations also involving NE architecture are widely described. In the present study, we utilized induced pluripotent stem cells (iPSCs) upon prolonged in vitro culture as a model to study aging and investigated the organization and expression pattern of NE major constituents. Confocal and four-dimensional imaging combined with molecular analyses, showed that aged iPSCs are characterized by nuclear dysmorphisms, nucleoskeletal components (lamin A/C-prelamin isoforms, lamin B1, emerin, and nesprin-2) imbalance, leading to impaired nucleo-cytoplasmic MKL1 shuttling, actin polymerization defects, mitochondrial dysfunctions, SIRT7 downregulation and NF-kBp65 hyperactivation. The observed age-related NE features of iPSCs closely resemble those reported for premature aging syndromes (e.g., Hutchinson-Gilford progeria syndrome) and for somatic cell senescence. These findings validate the use of aged iPSCs as a suitable cellular model to study senescence and for investigating therapeutic strategies aimed to treat premature aging.

  2. Study of Aging ion exchange membranes used in separation processes

    International Nuclear Information System (INIS)

    Bellakhal, N.; Ghalloussi, R.; Dammak, L.

    2009-01-01

    Presently, the most important application of ion exchange membranes (IEM) is the electrodialysis. This technique consists of a membrane separation using a series of anion exchange membranes alternately and cations, often used for the desalination of brackish water. These membranes are confronted with problems of aging. Indeed, the more they are used more physical and chemical properties will change. A comparative study of the behavior of both EMI and new but the same treatment is carried out by measuring a magnitude transfer characteristic: ion permeability. Ionic permeability is a physical quantity can have an idea about the selectivity of the membrane towards the charged species and the p orosity o f the membrane. It is a transport of ions (cations + anions) through the membrane. Thus, determining the ion permeability is to determine the diffusion flux of a strong electrolyte through a membrane separating two compartments (one containing electrolytes and other water initially ultrapure who will gradually electrolyte through the membrane). The measurement technique used is that by conductimetric detection because of the ease of its implementation and its accuracy. Thus, the variation of the concentration of the electrolyte is continuously monitored by measuring the conductivity of the solution diluted with time. The curves s = f (t) MEA and MEC new and used varying concentration of the electrolyte membranes show that let in less waste of strong electrolyte (NaCl and HCl) than new ones. This can be explained by: - The functional sites are combined with polyvalent ions present even in trace amounts in the solution process and become inactive. The membrane loses its hydrophilic character and turns into a film almost hydrophobic. - The chemical attacks and electrodialysis operations have degraded and eliminated much of the fixed sites leading to the same effects on the hydrophilic membrane. - These two assumptions have been reinforced by the extent of exchange

  3. Cerebral Hemodynamics in the Elderly: A Transcranial Doppler Study in the Einstein Aging Study Cohort.

    Science.gov (United States)

    Yang, Dixon; Cabral, Digna; Gaspard, Emmanuel N; Lipton, Richard B; Rundek, Tatjana; Derby, Carol A

    2016-09-01

    We sought to describe the relationship between age, sex, and race/ethnicity with transcranial Doppler hemodynamic characteristics from major intracerebral arterial segments in a large elderly population with varying demographics. We analyzed 369 stroke-free participants aged 70 years and older from the Einstein Aging Study. Single-gate, nonimaging transcranial Doppler sonography, a noninvasive sonographic technique that assesses real-time cerebrovascular hemodynamics, was used to interrogate 9 cerebral arterial segments. Individual Doppler spectra and cerebral blood flow velocities were acquired, and the pulsatility index and resistive index were calculated by the device's automated waveform-tracking function. Multiple linear regression models were used to examine the independent associations of age, sex, and race/ethnicity with transcranial Doppler measures, adjusting for hypertension, history of myocardial infarction or revascularization, and history of diabetes. Among enrolled participants, 303 individuals had at least 1 vessel insonated (mean age [SD], 80 [6] years; 63% women; 58% white; and 32% black). With age, transcranial Doppler measures of mean blood flow velocity were significantly decreased in the basilar artery (P = .001) and posterior cerebral artery (right, P = .003; left, P = .02). Pulsatility indices increased in the left middle cerebral artery (P = .01) and left anterior cerebral artery (P = .03), and the resistive index was increased in the left middle cerebral artery (P = .007) with age. Women had higher pulsatility and resistive indices compared to men in several vessels. We report a decreased mean blood flow velocity and weakly increased arterial pulsatility and resistance with aging in a large elderly stroke-free population. These referential trends in cerebrovascular hemodynamics may carry important implications in vascular diseases associated with advanced age, increased risk of cerebrovascular disease, cognitive decline, and dementia.

  4. Organic tanks safety program FY96 waste aging studies

    International Nuclear Information System (INIS)

    Camaioni, D.M.; Samuels, W.D.; Linehan, J.C.; Clauss, S.A.; Sharma, A.K.; Wahl, K.L.; Campbell, J.A.

    1996-10-01

    Uranium and plutonium production at the Hanford Site produced large quantities of radioactive by-products and contaminated process chemicals, which are stored in underground tanks awaiting treatment and disposal. Having been made strongly alkaline and then subjected to successive water evaporation campaigns to increase storage capacity, the wastes now exist in the physical forms of salt cakes, metal oxide sludges, and partially saturated aqueous brine solutions. The tanks that contain organic process chemicals mixed with nitrate/nitrite salt wastes may be at risk for fuel- nitrate combustion accidents. The purpose of the Waste Aging Task is to elucidate how chemical and radiological processes will have aged or degraded the organic compounds stored in the tanks. Ultimately, the task seeks to develop quantitative measures of how aging changes the energetic properties of the wastes. This information will directly support efforts to evaluate the hazard as well as to develop potential control and mitigation strategies

  5. Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study.

    Science.gov (United States)

    Singh, Jatinder; Schupf, Nicole; Boudreau, Robert; Matteini, Amy M; Prasad, Tanushree; Newman, Anne B; Liu, YongMei; Christensen, Kaare; Kammerer, Candace M

    2015-12-01

    One method by which to identify fundamental biological processes that may contribute to age-related disease and disability, instead of disease-specific processes, is to construct endophenotypes comprising linear combinations of physiological measures. Applying factor analyses methods to phenotypic data (2006-2009) on 28 traits representing 5 domains (cognitive, cardiovascular, metabolic, physical, and pulmonary) from 4,472 US and Danish individuals in 574 pedigrees from the Long Life Family Study (United States and Denmark), we constructed endophenotypes and assessed their relationship with mortality. The most dominant endophenotype primarily reflected the physical activity and pulmonary domains, was heritable, was significantly associated with mortality, and attenuated the association of age with mortality by 24.1%. Using data (1997-1998) on 1,794 Health, Aging and Body Composition Study participants from Memphis, Tennessee, and Pittsburgh, Pennsylvania, we obtained strikingly similar endophenotypes and relationships to mortality. We also reproduced the endophenotype constructs, especially the dominant physical activity and pulmonary endophenotype, within demographic subpopulations of these 2 cohorts. Thus, this endophenotype construct may represent an underlying phenotype related to aging. Additional genetic studies of this endophenotype may help identify genetic variants or networks that contribute to the aging process. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. LESBIAN, GAY, BISEXUAL, TRANSGENDER AGEING AND CARE: A LITERATURE STUDY

    Directory of Open Access Journals (Sweden)

    Henderson, Neil

    2016-08-01

    Full Text Available There is an increasing body of research on ageing and end-of-life care (EOLC of lesbian, gay, bisexual and transgender (LGBT older people in the UK, USA and Australia. In contrast, in South Africa, despite progressive legislation to protect LGBT rights, there has been minimal research in this area. This article reports on a critical review of literature on ageing of the LGBT community. Key themes identified include discrimination by health care workers and health risks for LGBT older people alongside the need for training of health professionals. The article concludes with consideration of the needs of LGBT persons in South Africa

  7. An Empirical Comparison of Different Models of Active Aging in Canada: The International Mobility in Aging Study.

    Science.gov (United States)

    Bélanger, Emmanuelle; Ahmed, Tamer; Filiatrault, Johanne; Yu, Hsiu-Ting; Zunzunegui, Maria Victoria

    2017-04-01

    Active aging is a concept that lacks consensus. The WHO defines it as a holistic concept that encompasses the overall health, participation, and security of older adults. Fernández-Ballesteros and colleagues propose a similar concept but omit security and include mood and cognitive function. To date, researchers attempting to validate conceptual models of active aging have obtained mixed results. The goal of this study was to examine the validity of existing models of active aging with epidemiological data from Canada. The WHO model of active aging and the psychological model of active aging developed by Fernández-Ballesteros and colleagues were tested with confirmatory factor analysis. The data used included 799 community-dwelling older adults between 65 and 74 years old, recruited from the patient lists of family physicians in Saint-Hyacinthe, Quebec and Kingston, Ontario. Neither model could be validated in the sample of Canadian older adults. Although a concept of healthy aging can be modeled adequately, social participation and security did not fit a latent factor model. A simple binary index indicated that 27% of older adults in the sample did not meet the active aging criteria proposed by the WHO. Our results suggest that active aging might represent a human rights policy orientation rather than an empirical measurement tool to guide research among older adult populations. Binary indexes of active aging may serve to highlight what remains to be improved about the health, participation, and security of growing populations of older adults. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. Quantitative analysis of the renal aging in rats. Stereological study.

    Science.gov (United States)

    Melchioretto, Eduardo Felippe; Zeni, Marcelo; Veronez, Djanira Aparecida da Luz; Martins, Eduardo Lopes; Fraga, Rogério de

    2016-05-01

    To evaluate the renal function and the renal histological alterations through the stereology and morphometrics in rats submitted to the natural process of aging. Seventy two Wistar rats, divided in six groups. Each group was sacrificed in a different age: 3, 6, 9, 12, 18 and 24 months. It was performed right nephrectomy, stereological and morphometric analysis of the renal tissue (renal volume and weight, density of volume (Vv[glom]) and numerical density (Nv[glom]) of the renal glomeruli and average glomerular volume (Vol[glom])) and also it was evaluated the renal function for the dosage of serum creatinine and urea. There was significant decrease of the renal function in the oldest rats. The renal volume presented gradual increase during the development of the rats with the biggest values registered in the group of animals at 12 months of age and significant progressive decrease in older animals. Vv[glom] presented statistically significant gradual reduction between the groups and the Nv[glom] also decreased significantly. The renal function proved to be inferior in senile rats when compared to the young rats. The morphometric and stereological analysis evidenced renal atrophy, gradual reduction of the volume density and numerical density of the renal glomeruli associated to the aging process.

  9. Study of aging effects in PWR power plants components - 15043

    International Nuclear Information System (INIS)

    Silva Borges, D. da; Lava, D.D.; Guimaraes, A.C.F.; Moreira, M. de L.

    2015-01-01

    In this paper we present a simulation about the aging process of the containment spray injection system (CSIS) of a pressurized water reactor (PWR) using the fault tree method (FT). The FT has the capacity to present the logic of events that leads to system unavailability, to capture frequency estimation of events, to model and calculate hazardous events frequency (before they happen) and help developing protective layers. The Monte Carlo method and Fussell-Vesely importance measure are used in this paper to determine the system unavailability probability and the most sensitive events to the aging process. The injection system fault tree consists of a main tree and 10 sub-trees. The main tree is composed of 35 basic events, 5 gates and 1 top event. The paper details the methodology. It can be seen that the increase of the failure rate of components due to the aging process, generates the increase in the general unavailability of the system that contains these components. The extension of the operating life of nuclear power plant must be accompanied by a special attention to the aging process of its components

  10. Aging driver and pedestrian safety : parking lot hazards study.

    Science.gov (United States)

    2012-06-20

    In 2009, Florida reported the highest rate of : pedestrian fatalities in the nation. At 2.51 : deaths per 100,000 residents, Floridas rate was : nearly twice the national average. These deaths : occurred in all age groups, but compared to : other ...

  11. Exercise, Arterial Crosstalk-Modulation, and Inflammation in an Aging Population: The ExAMIN AGE Study.

    Science.gov (United States)

    Streese, Lukas; Deiseroth, Arne; Schäfer, Juliane; Schmidt-Trucksäss, Arno; Hanssen, Henner

    2018-01-01

    Background: Age is a key determinant for the development of cardiovascular disease and higher age coincides with an increased prevalence of obesity and physical inactivity. The study examines the influence of physical activity on aging processes of physiological systems focusing on the mechanisms of vascular aging. Methods/Design: The study consists of two parts. The cross-sectional approach aims at examining the association of physical fitness and cardiovascular risk with large and small artery function in healthy older active (HOA, n = 40) and sedentary (HOS, n = 40) persons as well as older sedentary individuals with increased cardiovascular risk (OSR, n = 80) aged 50-80 years. In the interventional approach, the OSR group is randomized into a 12-week walking-based high intensity interval training (HIIT) group or a control condition, aiming at examining the effects of HIIT on arterial function in diseased older adults. Active lifestyle is defined as >9 metabolic equivalent of task (MET) per week and sedentary as ≤3 MET/week. Inclusion criteria for OSR are overweight or obesity (body mass index ≥30 kg/m 2 ) plus at least one additional cardiovascular risk factor. The primary outcome is arterial stiffness as determined by aortic pulse wave velocity (PWV). The secondary outcomes are retinal arterial and venous diameters. Further cardiovascular assessments include peripheral PWV, central haemodynamics, retinal endothelial function, carotid intima media thickness, cardiac strain and diastolic function as well as autonomic function and inflammation. Physical fitness is measured by a treadmill-based spiroergometry to determine peak oxygen uptake. Discussion: The aim of the study is to demonstrate the importance of and need for specific physical activity programs for seniors to achieve healthier aging as a long-term goal. Vascular function defines disease- and age-related end organ damage and represents the potential to contain health at older age. This research

  12. Exercise, Arterial Crosstalk-Modulation, and Inflammation in an Aging Population: The ExAMIN AGE Study

    Directory of Open Access Journals (Sweden)

    Lukas Streese

    2018-02-01

    Full Text Available Background: Age is a key determinant for the development of cardiovascular disease and higher age coincides with an increased prevalence of obesity and physical inactivity. The study examines the influence of physical activity on aging processes of physiological systems focusing on the mechanisms of vascular aging.Methods/Design: The study consists of two parts. The cross-sectional approach aims at examining the association of physical fitness and cardiovascular risk with large and small artery function in healthy older active (HOA, n = 40 and sedentary (HOS, n = 40 persons as well as older sedentary individuals with increased cardiovascular risk (OSR, n = 80 aged 50–80 years. In the interventional approach, the OSR group is randomized into a 12-week walking-based high intensity interval training (HIIT group or a control condition, aiming at examining the effects of HIIT on arterial function in diseased older adults. Active lifestyle is defined as >9 metabolic equivalent of task (MET per week and sedentary as ≤3 MET/week. Inclusion criteria for OSR are overweight or obesity (body mass index ≥30 kg/m2 plus at least one additional cardiovascular risk factor. The primary outcome is arterial stiffness as determined by aortic pulse wave velocity (PWV. The secondary outcomes are retinal arterial and venous diameters. Further cardiovascular assessments include peripheral PWV, central haemodynamics, retinal endothelial function, carotid intima media thickness, cardiac strain and diastolic function as well as autonomic function and inflammation. Physical fitness is measured by a treadmill-based spiroergometry to determine peak oxygen uptake.Discussion: The aim of the study is to demonstrate the importance of and need for specific physical activity programs for seniors to achieve healthier aging as a long-term goal. Vascular function defines disease- and age-related end organ damage and represents the potential to contain health at older age. This

  13. Ageing studies for the ATLAS MDT muonchambers and development of a gas filter to prevent drift tube ageing

    International Nuclear Information System (INIS)

    Koenig, S.

    2008-01-01

    The muon spectrometer of the ATLAS detector, which is currently assembled at the LHC accelerator at CERN, uses drift tubes as basic detection elements over most of the solid angle. The performance of these monitored drift tubes (MDTs), in particular their spatial resolution of 80 μm, determines the precision of the spectrometer. If ageing effects occur, the precision of the drift tubes will be degraded. Hence ageing effects have to be minimized or avoided altogether if possible. Even with a gas mixture of Ar:CO 2 =93:7, which was selected for its good ageing properties, ageing effects were observed in test systems. They were caused by small amounts of impurities, in particular volatile silicon compounds. Systematic studies revealed the required impurity levels deteriorating the drift tubes to be well below 1 ppm. Many components of the ATLAS MDT gas system are supplied by industry. In a newly designed ageing experiment in Freiburg these components were validated for their use in ATLAS. With a fully assembled ATLAS gas distribution rack as test component ageing effects were observed. It was therefore decided to install gas filters in the gas distribution lines to remove volatile silicon compounds efficiently from the gas mixture. Finally a filter was designed that can adsorb up to 5.5 g of volatile silicon compounds, hereby reducing the impurities in the outlet gas mixture to less than 30 ppb. (orig.)

  14. Ageing studies for the ATLAS MDT muonchambers and development of a gas filter to prevent drift tube ageing

    Energy Technology Data Exchange (ETDEWEB)

    Koenig, S.

    2008-01-15

    The muon spectrometer of the ATLAS detector, which is currently assembled at the LHC accelerator at CERN, uses drift tubes as basic detection elements over most of the solid angle. The performance of these monitored drift tubes (MDTs), in particular their spatial resolution of 80 {mu}m, determines the precision of the spectrometer. If ageing effects occur, the precision of the drift tubes will be degraded. Hence ageing effects have to be minimized or avoided altogether if possible. Even with a gas mixture of Ar:CO{sub 2}=93:7, which was selected for its good ageing properties, ageing effects were observed in test systems. They were caused by small amounts of impurities, in particular volatile silicon compounds. Systematic studies revealed the required impurity levels deteriorating the drift tubes to be well below 1 ppm. Many components of the ATLAS MDT gas system are supplied by industry. In a newly designed ageing experiment in Freiburg these components were validated for their use in ATLAS. With a fully assembled ATLAS gas distribution rack as test component ageing effects were observed. It was therefore decided to install gas filters in the gas distribution lines to remove volatile silicon compounds efficiently from the gas mixture. Finally a filter was designed that can adsorb up to 5.5 g of volatile silicon compounds, hereby reducing the impurities in the outlet gas mixture to less than 30 ppb. (orig.)

  15. Ageing studies for the ATLAS MDT Muonchambers and development of a gas filter to prevent drift tube ageing

    CERN Document Server

    König, Stefan

    2008-01-01

    The muon spectrometer of the ATLAS detector at CERN uses drift tubes as basic detection elements over most of the solid angle. The performance of these monitored drift tubes (MDTs), in particular their spatial resolution of 80 µm, determines the precision of the spectrometer. If ageing effects occur, the precision of the drift tubes will be degraded. Hence ageing effects have to be minimized or avoided altogether if possible. Even with a gas mixture of Ar:CO2 (93:7), which was selected for its good ageing properties, ageing effects were observed in test systems. They were caused by small amounts of impurities, in particular volatile silicon compounds. Systematic studies revealed the required impurity levels deteriorating the drift tubes to be well below 1 ppm. Many components of the ATLAS MDT gas system are supplied by industry. In a newly designed ageing experiment in Freiburg these components were validated for their use in ATLAS. With a fully assembled ATLAS gas distribution rack as test component ageing ...

  16. [A study on flomoxef against respiratory infections in the aged].

    Science.gov (United States)

    Tanimoto, H; Chonabayashi, N; Nakamori, Y; Nakatani, T; Yoshimura, K; Noguchi, M; Nakata, K

    1987-10-01

    Flomoxef (FMOX, 6315-S) was used in the treatment of 10 patients (male 8, female 2) with respiratory infections, and clinical responses and side effects of FMOX were evaluated. The mean age of the patients was 68.2 years, and the mean body weight was 45.8 kg; this background of the patients indicates that most of them were elderly, and light in body weight. FMOX was administrated by drip infusion in 1 g doses twice daily in all the cases. The mean duration of FMOX therapy was 14 days, and the mean total dose administered was 28 g. Efficacy rate was 80% in the 10 cases. Adverse reactions were not observed and no abnormalities in laboratory tests were detected. In conclusion, FMOX is an effective antibiotic in the treatment of aged patients with respiratory infections.

  17. Age-related changes in False Recognition: An ERP Study

    OpenAIRE

    Robb, Lindsey

    2011-01-01

    Episodic memory function is well known to decline with age and there is evidence to suggest seniors prone to forget events compared to younger adults (Aizpurua & Koutstaal, 2010). What’s more, seniors are inclined to falsely ‘remember’ events which did not happen. For example, seniors are more affected by misleading post-event information (e.g. lures), remembering that information as having occurred alongside the original event (Roediger & Geraci, 2007; Chan & McDermott, 2007; Koutstaal, 2006...

  18. Chronic pain, perceived stress, and cellular aging: an exploratory study

    Directory of Open Access Journals (Sweden)

    Sibille Kimberly T

    2012-02-01

    Full Text Available Abstract Background Chronic pain conditions are characterized by significant individual variability complicating the identification of pathophysiological markers. Leukocyte telomere length (TL, a measure of cellular aging, is associated with age-related disease onset, psychosocial stress, and health-related functional decline. Psychosocial stress has been associated with the onset of chronic pain and chronic pain is experienced as a physical and psychosocial stressor. However, the utility of TL as a biological marker reflecting the burden of chronic pain and psychosocial stress has not yet been explored. Findings The relationship between chronic pain, stress, and TL was analyzed in 36 ethnically diverse, older adults, half of whom reported no chronic pain and the other half had chronic knee osteoarthritis (OA pain. Subjects completed a physical exam, radiographs, health history, and psychosocial questionnaires. Blood samples were collected and TL was measured by quantitative polymerase chain reaction (qPCR. Four groups were identified characterized by pain status and the Perceived Stress Scale scores: 1 no pain/low stress, 2 no pain/high stress, chronic pain/low stress, and 4 chronic pain/high stress. TL differed between the pain/stress groups (p = 0.01, controlling for relevant covariates. Specifically, the chronic pain/high stress group had significantly shorter TL compared to the no pain/low stress group. Age was negatively correlated with TL, particularly in the chronic pain/high stress group (p = 0.03. Conclusions Although preliminary in nature and based on a modest sample size, these findings indicate that cellular aging may be more pronounced in older adults experiencing high levels of perceived stress and chronic pain.

  19. Age, growth rates, and paleoclimate studies of deep sea corals

    Science.gov (United States)

    Prouty, Nancy G; Roark, E. Brendan; Andrews, Allen; Robinson, Laura; Hill, Tessa; Sherwood, Owen; Williams, Branwen; Guilderson, Thomas P.; Fallon, Stewart

    2015-01-01

    Deep-water corals are some of the slowest growing, longest-lived skeletal accreting marine organisms. These habitat-forming species support diverse faunal assemblages that include commercially and ecologically important organisms. Therefore, effective management and conservation strategies for deep-sea corals can be informed by precise and accurate age, growth rate, and lifespan characteristics for proper assessment of vulnerability and recovery from perturbations. This is especially true for the small number of commercially valuable, and potentially endangered, species that are part of the black and precious coral fisheries (Tsounis et al. 2010). In addition to evaluating time scales of recovery from disturbance or exploitation, accurate age and growth estimates are essential for understanding the life history and ecology of these habitat-forming corals. Given that longevity is a key factor for population maintenance and fishery sustainability, partly due to limited and complex genetic flow among coral populations separated by great distances, accurate age structure for these deep-sea coral communities is essential for proper, long-term resource management.

  20. Burden of disability attributable to vertigo and dizziness in the aged: results from the KORA-Age study.

    Science.gov (United States)

    Mueller, Martin; Strobl, Ralf; Jahn, Klaus; Linkohr, Birgit; Peters, Annette; Grill, Eva

    2014-10-01

    Complaints of vertigo and dizziness are common in primary care in the aged. They can be caused by distinct vestibular disorders, but can also be a symptom in other conditions like non-vestibular sensory loss, vascular encephalopathy or anxiety. The aim of this study was to investigate the specific contribution of vertigo and dizziness to the total burden of disability in aged persons when controlling for the presence of other health conditions. Data originate from the MONICA/KORA study, a population-based cohort. Survivors of the original cohorts who were 65 years and older were examined by telephone interview in 2009. Disability was assessed with the Health Assessment Questionnaire. Logistic regression was used to adjust for potential confounders and additive regression to estimate the contribution of vertigo and dizziness to disability prevalence. Adjusted for age, sex and other chronic conditions, vertigo and dizziness were associated with disability (odds ratio 1.66, 95% confidence intervals 1.40-1.98). In both men and women between 65 and 79 years, vertigo and dizziness were among the strongest contributors to the burden of disability with a prevalence of 10.5% (6.6 to 15.1) in men and 9.0% (5.7 to 13.0) in women. In men, this effect is stable across all age-groups, whereas it decreases with age in women. Vertigo and dizziness independently and relevantly contribute to population-attributable disability in the aged. They are not inevitable consequences of ageing but arise from distinct disease entities. Careful management of vertigo and dizziness might increase population health and reduce disability. © The Author 2013. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  1. Maternal age and offspring developmental vulnerability at age five: A population-based cohort study of Australian children.

    Directory of Open Access Journals (Sweden)

    Kathleen Falster

    2018-04-01

    Full Text Available In recent decades, there has been a shift to later childbearing in high-income countries. There is limited large-scale evidence of the relationship between maternal age and child outcomes beyond the perinatal period. The objective of this study is to quantify a child's risk of developmental vulnerability at age five, according to their mother's age at childbirth.Linkage of population-level perinatal, hospital, and birth registration datasets to data from the Australian Early Development Census (AEDC and school enrolments in Australia's most populous state, New South Wales (NSW, enabled us to follow a cohort of 99,530 children from birth to their first year of school in 2009 or 2012. The study outcome was teacher-reported child development on five domains measured by the AEDC, including physical health and well-being, emotional maturity, social competence, language and cognitive skills, and communication skills and general knowledge. Developmental vulnerability was defined as domain scores below the 2009 AEDC 10th percentile cut point. The mean maternal age at childbirth was 29.6 years (standard deviation [SD], 5.7, with 4,382 children (4.4% born to mothers aged <20 years and 20,026 children (20.1% born to mothers aged ≥35 years. The proportion vulnerable on ≥1 domains was 21% overall and followed a reverse J-shaped distribution according to maternal age: it was highest in children born to mothers aged ≤15 years, at 40% (95% CI, 32-49, and was lowest in children born to mothers aged between 30 years and ≤35 years, at 17%-18%. For maternal ages 36 years to ≥45 years, the proportion vulnerable on ≥1 domains increased to 17%-24%. Adjustment for sociodemographic characteristics significantly attenuated vulnerability risk in children born to younger mothers, while adjustment for potentially modifiable factors, such as antenatal visits, had little additional impact across all ages. Although the multi-agency linkage yielded a broad range of

  2. Early vascular aging in young and middle-aged ischemic stroke patients: the Norwegian Stroke in the Young Study.

    Directory of Open Access Journals (Sweden)

    Sahrai Saeed

    Full Text Available Ischemic stroke survivors have high risk of cardiovascular morbidity and mortality even at young age, suggesting that early arterial aging is common among such patients.We measured aortic stiffness by carotid-femoral pulse wave velocity (PWV in 205 patients (69% men aged 15-60 years with acute ischemic stroke in the prospective Norwegian Stroke in the Young Study. High for age carotid-femoral PWV was identified in the reference normogram.Patients were on average 49 ± 10 years old, 34% had a history of hypertension and 37% had metabolic syndrome (MetS. In the total study population, higher PWV was associated with history of hypertension (β = 0.18, higher age (β = 0.34, systolic blood pressure (BP (β = 0.28 and serum creatinine (β = 0.18 and lower high-density lipoprotein (HDL cholesterol (β = -0.10, all p < 0.01 in multivariate linear regression analysis (multiple R2 = 0.42, p < 0.001. High for age PWV was found in 18% of patients. In univariate analyses, known hypertension was associated with a 6-fold, MetS with a 4-fold and presence of carotid plaque with a 3.7-fold higher risk for high for age PWV (all p < 0.01. In multiple logistic regression analysis higher systolic BP (odds ratio [OR] 1.04; 95% confidence interval [CI] 1.02-1.06; p < 0.01, history of hypertension (OR 3.59; 95% CI 1.52-8.51; p < 0.01, low HDL cholesterol (OR 3.03; 95% CI 1.00-9.09; p = 0.05 and higher serum creatinine (OR 1.04; 95% CI 1.01-1.06; p < 0.01 were associated with high for age PWV.Higher PWV is common in younger and middle-aged ischemic stroke patients and associated with a clustering of classical cardiovascular risk factors. ClinicalTrials.gov NCT01597453.

  3. Modeling Active Aging and Explicit Memory: An Empirical Study.

    Science.gov (United States)

    Ponce de León, Laura Ponce; Lévy, Jean Pierre; Fernández, Tomás; Ballesteros, Soledad

    2015-08-01

    The rapid growth of the population of older adults and their concomitant psychological status and health needs have captured the attention of researchers and health professionals. To help fill the void of literature available to social workers interested in mental health promotion and aging, the authors provide a model for active aging that uses psychosocial variables. Structural equation modeling was used to examine the relationships among the latent variables of the state of explicit memory, the perception of social resources, depression, and the perception of quality of life in a sample of 184 older adults. The results suggest that explicit memory is not a direct indicator of the perception of quality of life, but it could be considered an indirect indicator as it is positively correlated with perception of social resources and negatively correlated with depression. These last two variables influenced the perception of quality of life directly, the former positively and the latter negatively. The main outcome suggests that the perception of social support improves explicit memory and quality of life and reduces depression in active older adults. The findings also suggest that gerontological professionals should design memory training programs, improve available social resources, and offer environments with opportunities to exercise memory.

  4. Accelerated aging studies and environmental stability of prototype tamper tapes

    Energy Technology Data Exchange (ETDEWEB)

    Wright, B.W.; Wright, C.W. [Pacific Northwest Lab., Richland, WA (United States); Bunk, A.R. [Battelle Columbus Lab., OH (United States)] [and others

    1995-05-01

    This report describes the results of accelerated aging experiments (weathering) conducted on prototype tamper tapes bonded to a variety of surface materials. The prototype tamper tapes were based on the patented Confirm{reg_sign} tamper-indicating technology developed and produced by 3M Company. Tamper tapes bonded to surfaces using pressure sensitive adhesive (PSA) and four rapid-set adhesives were evaluated. The configurations of the PSA-bonded tamper tapes were 1.27-cm-wide Confirm{reg_sign} 1700 windows with vinyl underlay and 2.54-cm-wide Confirm{reg_sign} 1700 windows with vinyl and polyester underlays. The configurations of the rapid-set adhesive-bonded tamper tapes were 2.54-cm-wide Confirm{reg_sign} (1700, 1500 with and without primer, and 1300) windows with vinyl underlay. Surfaces used for bonding included aluminum, steel, stainless steel, Kevlar{reg_sign}, brass, copper, fiberglass/resin with and without gel coat, polyurethane-painted steel, acrylonitrile:butadiene:styrene plastic, polyester fiberglass board, Lexan polycarbonate, and cedar wood. Weathering conditions included a QUV cabinet (ultraviolet light at 60{degrees}C, condensing humidity at 40{degrees}C), a thermal cycling cabinet (-18{degrees}C to 46{degrees}C), a Weather-O-Meter (Xenon lamp), and exposure outdoors in Daytona Beach, Florida. Environmental aging exposures lasted from 7 weeks to 5 months. After exposure, the tamper tapes were visually examined and tested for transfer resistance. Tamper tapes were also exposed to a variety of chemical liquids (including organic solvents, acids, bases, and oxidizing liquids) to determine chemical resistance and to sand to determine abrasion resistance.

  5. Body image, aging, and identity in women over 50: The Gender and Body Image (GABI) study.

    Science.gov (United States)

    Hofmeier, Sara M; Runfola, Cristin D; Sala, Margarita; Gagne, Danielle A; Brownley, Kimberly A; Bulik, Cynthia M

    2017-01-01

    We conducted a qualitative study of 1,849 women over age 50 to capture the thoughts, feelings, and attitudes that women at middle age have about their bodies and the experience of aging. Via an open-ended question online survey, four primary themes emerged: (a) the physical and psychological experience of aging; (b) the injustices, inequities, and challenges of aging; (c) the importance of self-care; and (d) a plea for recognition of the need to maintain a contributory role in society. Results highlight the complexities of women's psychological and physical aspects of aging and point toward important topics worthy of further study in this growing population.

  6. An evaluation of third molar eruption for assessment of chronologic age: A panoramic study.

    Science.gov (United States)

    Tuteja, Monica; Bahirwani, Shraddha; Balaji, P

    2012-01-01

    The identity of a person can be established by assessing one's age, and in order to be entitled to civil rights and social benefits, verification of the chronological age is required and thereby age estimation has gained an increasing significance in recent years. Tooth eruption is one of the criteria of developmental morphology that can be evaluated by either clinical examination or by evaluation of dental radiographs to determine the dental age. The present study was aimed to evaluate the reliability of the third molar eruption stage as a parameter for forensic age estimation in living subjects. The stage of wisdom tooth eruption in 77 male and 73 female Indian subjects aged between 12-26 years was determined by subjecting them to conventional orthopantomograms and was interpreted to assess the third molar eruption stages to evaluate the dental age. Predicted minimum age and mean age of the study sample were found to be significant predictors (Page. Minimum age was able to explain 58.3% of the variation in actual age and the mean age was able to explain 60.3% of variation in actual age. Third molar is fairly a reliable indicator to determine the age of alveolar, gingival, and complete emergence of third molar in the occlusal plane in adolescents and young adults. Minimum and most probable ages of examined subjects can also be evaluated using third molar eruption stage.

  7. Personality Traits Predict the Developmental Course of Externalizing: A Four-Wave Longitudinal Study Spanning Age 17 to Age 29.

    Science.gov (United States)

    Walton, Kate E; Krueger, Robert F; Elkins, Irene; D'Accordo, Cassandra; McGue, Matt; Iacono, William G

    2017-06-01

    The objective of the present study was to determine whether and how personality predicts the developmental course of externalizing problems, including antisocial behavior and substance dependence. In a large, population-based longitudinal study (N = 1,252), the 11 personality traits assessed by the Multidimensional Personality Questionnaire were measured at age 17, and DSM diagnoses of adult antisocial behavior, alcohol dependence, and drug dependence were obtained at ages 17, 20, 24, and 29. We fit a quadratic multiple indicator latent growth model where the three diagnoses loaded onto an externalizing factor. This model fit the data well, and externalizing increased until it started to decline at age 24. High aggression and low control were the most significant predictors of the development of externalizing, with aggression playing a significant role in the development of externalizing across the 12-year time span, and control predicting the development from age 17 to 24. The findings highlight the importance of considering the developmental course of externalizing in the context of personality and suggest that the specific personality traits of aggression and control might be targeted in externalizing prevention and intervention programs. © 2016 Wiley Periodicals, Inc.

  8. Personality Traits Predict the Developmental Course of Externalizing: A Four-wave Longitudinal Study Spanning Age 17 to Age 29

    Science.gov (United States)

    Walton, Kate E.; Krueger, Robert F.; Elkins, Irene; D’Accordo, Cassandra; McGue, Matt; Iacono, William G.

    2016-01-01

    Objective The objective of the present study was to determine whether and how personality predicts the developmental course of externalizing problems, including antisocial behavior and substance dependence. Method In a large population-based longitudinal study (N=1252), the 11 personality traits assessed by the Multidimensional Personality Questionnaire were measured at age 17, and DSM diagnoses of adult antisocial behavior, alcohol dependence, and drug dependence were obtained at ages 17, 20, 24, and 29. We fit a quadratic multiple indicator latent growth model where the three diagnoses loaded onto an externalizing factor. Results This model fit the data well, and externalizing increased until it started to decline at age 24. High aggression and low control were the most significant predictors of the development of externalizing, with aggression playing a significant role in the development of externalizing across the 12-year time span, and control predicting the development from age 17 to 24. Conclusions The findings highlight the importance of considering the developmental course of externalizing in the context of personality and suggest that the specific personality traits of aggression and control might be targeted in externalizing prevention and intervention programs. PMID:26808279

  9. N-terminal pro-brain natriuretic peptide and abnormal brain aging: The AGES-Reykjavik Study.

    Science.gov (United States)

    Sabayan, Behnam; van Buchem, Mark A; de Craen, Anton J M; Sigurdsson, Sigurdur; Zhang, Qian; Harris, Tamara B; Gudnason, Vilmundur; Arai, Andrew E; Launer, Lenore J

    2015-09-01

    To investigate the independent association of serum N-terminal fragment of the prohormone natriuretic peptide (NT-proBNP) with structural and functional features of abnormal brain aging in older individuals. In this cross-sectional study based on the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we included 4,029 older community-dwelling individuals (born 1907 to 1935) with a measured serum level of NT-proBNP. Outcomes included parenchymal brain volumes estimated from brain MRI, cognitive function measured by tests of memory, processing speed, and executive functioning, and presence of depressive symptoms measured using the Geriatric Depression Scale. In a substudy, cardiac output of 857 participants was assessed using cardiac MRI. In multivariate analyses, adjusted for sociodemographic and cardiovascular factors, higher levels of NT-proBNP were independently associated with lower total (p brain volumes. Likewise, in multivariate analyses, higher levels of NT-proBNP were associated with worse scores in memory (p = 0.005), processing speed (p = 0.001), executive functioning (p brain parenchymal volumes, impaired executive function and processing speed, and higher depressive symptoms were independent of the level of cardiac output. Higher serum levels of NT-proBNP, independent of cardiovascular risk factors and a measure of cardiac function, are linked with alterations in brain structure and function. Roles of natriuretic peptides in the process of brain aging need to be further elucidated. © 2015 American Academy of Neurology.

  10. The role of age of disclosure of biological origins in the psychological wellbeing of adolescents conceived by reproductive donation: a longitudinal study from age 1 to age 14.

    OpenAIRE

    Ilioi, Elena; Blake, Lucy; Jadva, Vasanti Harish; Roman, Gabriela; Golombok, Susan Esther

    2017-01-01

    $\\textbf{BACKGROUND}$: The question of whether children should be told of their biological origins is one of the most controversial issues regarding the birth of children through donated eggs, sperm, embryos or surrogacy. $\\textbf{METHODS}$: In the sixth phase of this longitudinal study when the children were aged 14 years, family relationships and adolescent adjustment were examined in 87 families created through reproductive donation and 54 natural conception families. The quality of f...

  11. The role of age of disclosure of biological origins in the psychological wellbeing of adolescents conceived by reproductive donation: a longitudinal study from age 1 to age 14

    OpenAIRE

    Ilioi, Elena; Blake, Lucy; Jadva, Vasanti; Roman, Gabriela; Golombok, Susan

    2016-01-01

    Background The question of whether children should be told of their biological origins is one of the most controversial issues regarding the birth of children through donated eggs, sperm, embryos or surrogacy. Methods In the sixth phase of this longitudinal study when the children were aged 14?years, family relationships and adolescent adjustment were examined in 87 families created through reproductive donation and 54 natural conception families. The quality of family relationships was asses...

  12. Age at menarche and age at natural menopause in East Asian women: a genome-wide association study.

    Science.gov (United States)

    Shi, Jiajun; Zhang, Ben; Choi, Ji-Yeob; Gao, Yu-Tang; Li, Huaixing; Lu, Wei; Long, Jirong; Kang, Daehee; Xiang, Yong-Bing; Wen, Wanqing; Park, Sue K; Ye, Xingwang; Noh, Dong-Young; Zheng, Ying; Wang, Yiqin; Chung, Seokang; Lin, Xu; Cai, Qiuyin; Shu, Xiao-Ou

    2016-12-01

    Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high heritability. Abnormal timing of menarche or menopause is associated with a reduced span of fertility and risk for several age-related diseases including breast, endometrial and ovarian cancer, cardiovascular disease, and osteoporosis. To identify novel genetic loci for AM or ANM in East Asian women and to replicate previously identified loci primarily in women of European ancestry by genome-wide association studies (GWASs), we conducted a two-stage GWAS. Stage I aimed to discover promising novel AM and ANM loci using GWAS data of 8073 women from Shanghai, China. The Stage II replication study used the data from another Chinese GWAS (n = 1230 for AM and n = 1458 for ANM), a Korean GWAS (n = 4215 for AM and n = 1739 for ANM), and de novo genotyping of 2877 additional Chinese women. Previous GWAS-identified loci for AM and ANM were also evaluated. We identified two suggestive menarcheal age loci tagged by rs79195475 at 10q21.3 (beta = -0.118 years, P = 3.4 × 10 -6 ) and rs1023935 at 4p15.1 (beta = -0.145 years, P = 4.9 × 10 -6 ) and one menopausal age locus tagged by rs3818134 at 22q12.2 (beta = -0.276 years, P = 8.8 × 10 -6 ). These suggestive loci warrant a further validation in independent populations. Although limited by low statistical power, we replicated 19 of the 98 menarche loci and 5 of the 20 menopause loci previously identified in women of European ancestry in East Asian women, suggesting a shared genetic architecture for these two traits across populations.

  13. The Mediterranean healthy eating, ageing, and lifestyle (MEAL) study: rationale and study design.

    Science.gov (United States)

    Grosso, Giuseppe; Marventano, Stefano; D'Urso, Maurizio; Mistretta, Antonio; Galvano, Fabio

    2017-08-01

    There is accumulating evidence suggesting that Mediterranean lifestyles, including nutrition and sleeping patterns as well as social integration, may play a role in reducing age-related diseases. However, the literature is mostly deficient of evidence provided by Italian Mediterranean islands that more closely adhered to the originally described lifestyles. In this paper, we described the rationale and the study design of the Mediterranean healthy Eating, Ageing, and Lifestyle (MEAL) study, a prospective population-based cohort established in Sicily, southern Italy. The main exposures investigated are classical determinants of health, including demographic, nutritional habits, smoking and physical activity status, as well as eating-related behaviors, sleeping habits, sun exposure, social resources, and perceived stress. Anthropometric measurements will be collected. The main outcomes included depression, quality of life, and, after the follow-up period, also cardiovascular disease and cancer. The MEAL study may provide important data to increase our knowledge regarding the prevalence, incidence, and risk factors of age-related disorders in the Mediterranean region.

  14. The Philosophy of Local Studies in the Interactive Age

    Science.gov (United States)

    Reid, Peter H.; Macafee, Caroline

    2007-01-01

    The authors examine strategic priorities for local studies libraries in the context of the interactive Web. They examine the implications for access, investigations and the needs of different users. The philosophy that has previously guided local studies is articulated as a number of maxims, taking into account also social inclusion and lifelong…

  15. Rhetoric to action: a study of stakeholder perceptions of aging well in two local communities.

    Science.gov (United States)

    Everingham, Jo-Anne; Lui, Chi-Wai; Bartlett, Helen; Warburton, Jeni; Cuthill, Michael

    2010-11-01

    This qualitative study of local perceptions of policy goals and action in relation to aging reports 31 stakeholder interviews within 2 Australian communities exploring (a) the meaning of aging well; and (b) preferred policy actions to achieve positive aging outcomes. Findings suggest that community perceptions of aging well are broadly consistent with the goals of national and international policy frameworks in focusing on 3 dimensions--health, social engagement, and security. Further, participants believe that achievement of positive aging outcomes requires a mix of self-help, community action, and government intervention--particularly government support and encouragement for aging well initiatives.

  16. Age-related weakness of proximal muscle studied with motor cortical mapping: a TMS study.

    Directory of Open Access Journals (Sweden)

    Ela B Plow

    Full Text Available Aging-related weakness is due in part to degeneration within the central nervous system. However, it is unknown how changes to the representation of corticospinal output in the primary motor cortex (M1 relate to such weakness. Transcranial magnetic stimulation (TMS is a noninvasive method of cortical stimulation that can map representation of corticospinal output devoted to a muscle. Using TMS, we examined age-related alterations in maps devoted to biceps brachii muscle to determine whether they predicted its age-induced weakness. Forty-seven right-handed subjects participated: 20 young (22.6 ± 0.90 years and 27 old (74.96 ± 1.35 years. We measured strength as force of elbow flexion and electromyographic activation of biceps brachii during maximum voluntary contraction. Mapping variables included: 1 center of gravity or weighted mean location of corticospinal output, 2 size of map, 3 volume or excitation of corticospinal output, and 4 response density or corticospinal excitation per unit area. Center of gravity was more anterior in old than in young (p<0.001, though there was no significant difference in strength between the age groups. Map size, volume, and response density showed no significant difference between groups. Regardless of age, center of gravity significantly predicted strength (β = -0.34, p = 0.005, while volume adjacent to the core of map predicted voluntary activation of biceps (β = 0.32, p = 0.008. Overall, the anterior shift of the map in older adults may reflect an adaptive change that allowed for the maintenance of strength. Laterally located center of gravity and higher excitation in the region adjacent to the core in weaker individuals could reflect compensatory recruitment of synergistic muscles. Thus, our study substantiates the role of M1 in adapting to aging-related weakness and subtending strength and muscle activation across age groups. Mapping from M1 may offer foundation for an examination of mechanisms that

  17. The global status of freshwater fish age validation studies and a prioritization framework for future research

    Science.gov (United States)

    Pope, Kevin L.; Hamel, Martin J.; Pegg, Mark A.; Spurgeon, Jonathan J.

    2016-01-01

    Age information derived from calcified structures is commonly used to estimate recruitment, growth, and mortality for fish populations. Validation of daily or annual marks on age structures is often assumed, presumably due to a lack of general knowledge concerning the status of age validation studies. Therefore, the current status of freshwater fish age validation studies was summarized to show where additional effort is needed, and increase the accessibility of validation studies to researchers. In total, 1351 original peer-reviewed articles were reviewed from freshwater systems that studied age in fish. Periodicity and age validation studies were found for 88 freshwater species comprising 21 fish families. The number of age validation studies has increased over the last 30 years following previous calls for more research; however, few species have validated structures spanning all life stages. In addition, few fishes of conservation concern have validated ageing structures. A prioritization framework, using a combination of eight characteristics, is offered to direct future age validation studies and close the validation information gap. Additional study, using the offered prioritization framework, and increased availability of published studies that incorporate uncertainty when presenting research results dealing with age information are needed.

  18. STUDY OF DURATION INFLUENCE OF ARTIFICIAL AGING ON THE PROPERTIES OF STEEL

    OpenAIRE

    Ms. Irina L. Polyanskaya; Ms. Nina V. Filisyuk

    2016-01-01

    The article presents the studies of artificial strain aging of pipe steels. Changes in temperature accelerate the aging process, which resulted in a change of its microstructure. The effect of strain aging on the mechanical properties of the steel in toughness tests is determined.

  19. Age at menopause in women with type 1 diabetes mellitus : the OVADIA study

    NARCIS (Netherlands)

    Yarde, F.; van der Schouw, Y. T.; de Valk, H. W.; Franx, A.; Eijkemans, M. J. C.; Spierings, W.; Fauser, Bart; Broekmans, F. J. M.

    STUDY QUESTION: Is type 1 diabetes a determinant of advanced ovarian ageing, resulting in an early age at natural menopause? SUMMARY ANSWER: No clear evidence was provided that type 1 diabetes is a determinant of accelerated ovarian ageing resulting in an early menopause. WHAT IS KNOWN ALREADY: The

  20. Exploring Aging Attitudes through a Puppet Making Research Study

    Science.gov (United States)

    Whiteland, Susan R.

    2016-01-01

    Intergenerational programs often reduce ageism and stereotypical thinking. This author uses a mixed methods case study to investigate how attitudes may change when older adults and children participate in an intergenerational art project. The research question, "Is there a positive correlation in children's attitudes toward older adults and…

  1. Ageing of structural materials in tokamaks: TEXTOR liner study

    Science.gov (United States)

    Weckmann, A.; Petersson, P.; Rubel, M.; Fortuna-Zaleśna, E.; Zielinski, W.; Romelczyk-Baishya, B.; Grigore, E.; Ruset, C.; Kreter, A.

    2017-12-01

    After the final shut-down of the tokamak TEXTOR, all of its machine parts became accessible for comprehensive studies. This unique opportunity enabled the study of the Inconel 625 liner by a wide range of methods. The aim was to evaluate eventual alteration of surface and bulk characteristics from recessed wall elements that may influence the machine performance. The surface was covered with stratified layers consisting mainly of boron, carbon, oxygen, and in some cases also silicon. Wall conditioning and limiter materials hence predominantly define deposition on the liner. Deposited layers on recessed wall elements reach micrometre thickness within decades, peel off and may contribute to the dust inventory in tokamaks. Deuterium content was about 4,7 at% on average most probably due to wall conditioning with deuterated gas, and very low concentration in the Inconel substrate. Inconel 625 retained its mechanical strength despite 26 years of cyclic heating, stresses and particle bombardment.

  2. Study of cnidarian-algal symbiosis in the "omics" age.

    Science.gov (United States)

    Meyer, Eli; Weis, Virginia M

    2012-08-01

    The symbiotic associations between cnidarians and dinoflagellate algae (Symbiodinium) support productive and diverse ecosystems in coral reefs. Many aspects of this association, including the mechanistic basis of host-symbiont recognition and metabolic interaction, remain poorly understood. The first completed genome sequence for a symbiotic anthozoan is now available (the coral Acropora digitifera), and extensive expressed sequence tag resources are available for a variety of other symbiotic corals and anemones. These resources make it possible to profile gene expression, protein abundance, and protein localization associated with the symbiotic state. Here we review the history of "omics" studies of cnidarian-algal symbiosis and the current availability of sequence resources for corals and anemones, identifying genes putatively involved in symbiosis across 10 anthozoan species. The public availability of candidate symbiosis-associated genes leaves the field of cnidarian-algal symbiosis poised for in-depth comparative studies of sequence diversity and gene expression and for targeted functional studies of genes associated with symbiosis. Reviewing the progress to date suggests directions for future investigations of cnidarian-algal symbiosis that include (i) sequencing of Symbiodinium, (ii) proteomic analysis of the symbiosome membrane complex, (iii) glycomic analysis of Symbiodinium cell surfaces, and (iv) expression profiling of the gastrodermal cells hosting Symbiodinium.

  3. Determinants of resilience for people ageing in remote places: a case study in northern Australia

    Directory of Open Access Journals (Sweden)

    Heather Gibb

    2018-02-01

    Full Text Available The purpose of this study was to investigate how people managed to stay resilient as they aged in remote places. In Western developed countries, 'successful ageing' is associated with older people's right to age in their chosen place. To remain resilient, older people require support to supplement diminishing self-reliance associated with increasing frailty. Such support services do not extend to remote communities, making it difficult to age in place. This article reports on a case study of ageing in remote places, from the perspective of seniors within a small community in remote northern Australia. The study found how older people attempt through volunteer efforts, to supplement the gaps in aged support services. This collective effort to achieve ageing in place demonstrated greater integration with place and social resilience within the community. However, seniors' social resilience was seen as tenuous, given collective self-reliance is based on volunteer efforts of older people.

  4. Short- and long-term outcomes of laparoscopic surgery vs open surgery for transverse colon cancer: a retrospective multicenter study.

    Science.gov (United States)

    Kim, Jong Wan; Kim, Jeong Yeon; Kang, Byung Mo; Lee, Bong Hwa; Kim, Byung Chun; Park, Jun Ho

    2016-01-01

    The purpose of the present study was to compare the perioperative and oncologic outcomes between laparoscopic surgery and open surgery for transverse colon cancer. We conducted a retrospective review of patients who underwent surgery for transverse colon cancer at six Hallym University-affiliated hospitals between January 2005 and June 2015. The perioperative outcomes and oncologic outcomes were compared between laparoscopic and open surgery. Of 226 patients with transverse colon cancer, 103 underwent laparoscopic surgery and 123 underwent open surgery. There were no differences in the patient characteristics between the two groups. Regarding perioperative outcomes, the operation time was significantly longer in the laparoscopic group than in the open group (267.3 vs 172.7 minutes, Pstudy showed that laparoscopic surgery is associated with several perioperative benefits and similar oncologic outcomes to open surgery for the resection of transverse colon cancer. Therefore, laparoscopic surgery offers a safe alternative to open surgery in patients with transverse colon cancer.

  5. Condition monitoring: a study on ageing in Inconel 718

    International Nuclear Information System (INIS)

    Acharya, Vidhi; Murthy, G.V.S.

    2015-01-01

    The development of contemporary high temperature materials is needed to enable the successful introduction of cleaner and more efficient next generation power plants. Due to inherent limitations in steels, new high temperature materials must be selected for a change in operating parameters. Inconel-718 is currently considered to be one of the leading materials for use in high temperature applications. Due to its excellent high-temperature mechanical properties, Inconel-718 is believed to be a contender for forged components of Advanced Ultra-Supercritical (A-USC) power plants. The A-USC power plant with steam conditions of 700°C/35 MPa, is expected to have greater efficiency. Thus the microstructural stability and its impact on the mechanical properties of this alloy at elevated temperatures will certainly be a crucial factor that influences the reliability of the power plants. Therefore it is of imminent importance to study the microstructural evolution of components made out of Inconel-718 preferably by Non-destructive methods

  6. The longitudinal urban cohort ageing study (LUCAS: study protocol and participation in the first decade

    Directory of Open Access Journals (Sweden)

    Dapp Ulrike

    2012-07-01

    Full Text Available Abstract Background We present concept, study protocol and selected baseline data of the Longitudinal Urban Cohort Ageing Study (LUCAS in Germany. LUCAS is a long-running cohort study of community-dwelling seniors complemented by specific studies of geriatric patients or diseases. Aims were to (1 Describe individual ageing trajectories in a metropolitan setting, documenting changes in functional status, the onset of frailty, disability and need of care; (2 Find determinants of healthy ageing; (3 Assess long-term effects of specific health promotion interventions; (4 Produce results for health care planning for fit, pre-frail, frail and disabled elderly persons; (5 Set up a framework for embedded studies to investigate various hypotheses in specific subgroups of elderly. Methods/Design In 2000, twenty-one general practitioners (GPs were recruited in the Hamburg metropolitan area; they generated lists of all their patients 60 years and older. Persons not terminally ill, without daily need of assistance or professional care were eligible. Of these, n = 3,326 (48 % agreed to participate and completed a small (baseline and an extensive health questionnaire (wave 1. In 2007/2008, a re-recruitment took place including 2,012 participants: 743 men, 1,269 women (647 deaths, 197 losses, 470 declined further participation. In 2009/2010 n = 1,627 returned the questionnaire (90 deaths, 47 losses, 248 declined further participation resulting in a good participation rate over ten years with limited and quantified dropouts. Presently, follow-up data from 2007/2008 (wave 2 and 2009/2010 (wave 3 are available. Data wave 4 is due in 2011/2012, and the project will be continued until 2013. Information on survival and need of nursing care was collected continuously and cross-checked against official records. We used Fisher’s exact test and t-tests. The study served repeatedly to evaluate health promotion interventions and concepts. Discussion LUCAS

  7. A mechanistic understanding of ageing revealed by studying the young.

    Science.gov (United States)

    Crespi, Erica J

    2012-03-01

    A main focus within biomedical research is to understand how adverse environmental conditions experienced during early development affects lifelong health (Barker 1992). Within this context, extensive research in rodent models and humans has shown that intrauterine growth retardation (IUGR) caused by nutrient restriction during early development is often followed by post-natal 'catch-up' growth when access to food resources improves. However, this accelerated growth rate seems to come at a cost, as metabolic and endocrine processes that are programmed during this time cause later-life onset of diseases such as obesity, insulin resistance and cardiovascular disease (reviewed in Crespi & Denver 2005). In this issue Molecular Ecology, Geiger et al. (2012) asked what are the costs of catch-up growth in nutrient-restricted king penguin chicks (Fig. 1) by measuring lengths of telomeres, the protective DNA sequences at the end of chromosomes, before and after catch-up growth, as the amount and rate of telomere sequence loss over time has been associated with reduced lifespan in both model and nonmodel organisms (see reviews of Costantini et al. 2010; Haussmann & Marchetto 2010). Geiger et al. (2011) found that chicks entering the post-winter growth season at a smaller size exhibited increased growth rates (i.e. catch-up growth) at the cost of increased oxidative stress and reduced telomere lengths compared with the chicks entering the growth period at a larger size. Furthermore, chicks that did not survive had drastically shorter telomere lengths and reduced antioxidant capacities at the beginning of the growth period than all other chicks, thereby directly associating telomere length to mortality. These results suggest that while catch-up growth allows smaller chicks to head off into the world on equal footing with chicks that hatched at a larger size, it likely comes at the cost of a shortened lifespan. Thus, this study provides a mechanism that supports the

  8. Acromegaly and aging: a comparative cross-sectional study.

    Science.gov (United States)

    Hatipoglu, Esra; Yuruyen, Mehmet; Keskin, Ela; Yavuzer, Hakan; Niyazoglu, Mutlu; Doventas, Alper; Erdincler, Deniz Suna; Beger, Tanju; Kadioglu, Pinar; Gundogdu, Sadi

    2015-02-01

    Cognitive and functional geriatric assessment may change in acromegaly. Herein we aimed to determine at which points geriatric assessment of the cases with acromegaly differs from that of general elderly population. In this comparative cross-sectional study, a total of 30 cases with acromegaly (controlled n = 14, uncontrolled n = 16) and 30 gender and body-mass index-matched cases without acromegaly (control group, CG) above 60 years old were included. Cognitive functions were evaluated on the basis of the mini-mental state exam (MMSE). Affective status was determined using the geriatric depression scale. Activities of daily living (ADL) were ranked according to the Barthel index while instrumental activities of daily living (IADL) were graded on the basis of the Lawton scale. Nutritional status was evaluated using the mini-nutritional assessment (MNA). Body composition was measured through bioimpedance analysis. Functional mobility was determined using the Timed Up and Go test (TUG) and muscle strength with the handgrip strength test. Scores on the MMSE were significantly lower in the elderly cases with acromegaly than in the cases without acromegaly (p < 0.001). Dementia was more frequent in the acromegaly group than in the CG (p = 0.04). Total MNA scores were significantly lower in cases with acromegaly than in the CG (p = 0.006). More subjects in the acromegaly group (33%) were at greater risk of malnutrition than in the CG (3%) (p = 0.003). There was greater moderate functional impairment based on Barthel ADL in the acromegaly group than in the CG (p = 0.04). Acromegaly may impair cognitive functions, functional mobility and instrumental daily living activities in the geriatric population. With acromegaly, the risk of malnutrition may also increase. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Perceptions of Successful Ageing Among Iranian Elders: Insights From a Qualitative Study.

    Science.gov (United States)

    Zanjari, Nasibeh; Sharifian Sani, Maryam; Hosseini Chavoshi, Meimanat; Rafiey, Hassan; Mohammadi Shahboulaghi, Farahnaz

    2016-10-01

    The aim of this article is to explore the perceptions of successful ageing among Iranian elderly. The data were collected in Tehran city on 60 older adults using a semistructured interview. The collected data were analyzed using directed content analysis. The findings revealed various dimensions of successful ageing among Iranian older adults. Social well-being is the most prevalent dimension of successful ageing, followed by psychological well-being, physical health, spirituality and transcendence, financial security, and an elder-friendly environmental and social context. Also, the findings from this study provide a new understanding of successful ageing in the context of Iran and contribute additional elements. This qualitative study highlights the importance of multidimensional and contextual viewpoints to successful ageing. In conclusion, to achieve multidimensional successful ageing, the interaction between all levels of successful ageing such as individual, family, and environment must be considered. © The Author(s) 2016.

  10. Cross-Sectional Study of Gender Role Conflict Examining College-Aged and Middle-Aged Men.

    Science.gov (United States)

    Cournoyer, Robert J.; And Others

    1995-01-01

    College-aged (n=88) and middle-aged (n=89) men completed 5 measures that assess gender role conflict and psychological well-being. Results indicate that, compared with college-aged men, middle-aged men were less conflicted about success, power, and competition, but were more conflicted about work and family responsibilities. The discussion focuses…

  11. Study of age and growth of Indian sand whiting, sillago sihama (Forsskal) from Zuari estuary, Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Shamsan, E.F.; Ansari, Z.A.

    it is useful to determine the age of the candidate species. The knowledge of age and growth of an economically important fish is essential for understanding the age composition of the stocks and the role of various class-years in the fisheries. It is also... essential to determine the mortality and survival rate of various year-classes and success of the yearly broods after recruitment. Accordingly, knowledge of age and growth is of vital importance in the fisheries management. It is proposed to study age...

  12. The use of music in aged care facilities: A mixed-methods study.

    Science.gov (United States)

    Garrido, Sandra; Dunne, Laura; Perz, Janette; Chang, Esther; Stevens, Catherine J

    2018-02-01

    Music is frequently used in aged care, being easily accessible and cost-effective. Research indicates that certain types of musical engagement hold greater benefits than others. However, it is not clear how effectively music is utilized in aged care facilities and what the barriers are to its further use. This study used a mixed-methods paradigm, surveying 46 aged care workers and conducting in-depth interviews with 5, to explore how music is used in aged care facilities in Australia, staff perceptions of the impact of music on residents, and the barriers to more effective implementation of music in aged care settings.

  13. Adoptive paternal age and risk of psychosis in adoptees: a register based cohort study.

    Directory of Open Access Journals (Sweden)

    Mats Ek

    Full Text Available The association between advancing paternal age and increased risk of schizophrenia in the off-spring is well established. The underlying mechanisms are unknown. In order to investigate whether the psychosocial environment associated with growing up with an aged father explains the increased risk we conducted a study of all adoptive children in Sweden from 1955-1985 (n =31 188. Their risk of developing schizophrenia or non-affective psychosis in relation to advancing age of their adoptive fathers' was examined. We found no association between risk of psychoses and advancing adoptive paternal age. There was no support of psychosocial environmental factors explaining the "paternal age effect".

  14. The role of age of disclosure of biological origins in the psychological wellbeing of adolescents conceived by reproductive donation: a longitudinal study from age 1 to age 14.

    Science.gov (United States)

    Ilioi, Elena; Blake, Lucy; Jadva, Vasanti; Roman, Gabriela; Golombok, Susan

    2017-03-01

    The question of whether children should be told of their biological origins is one of the most controversial issues regarding the birth of children through donated eggs, sperm, embryos or surrogacy. In the sixth phase of this longitudinal study when the children were aged 14 years, family relationships and adolescent adjustment were examined in 87 families created through reproductive donation and 54 natural conception families. The quality of family relationships was assessed by standardised interview with mothers and by standardised questionnaires and an observational measure with mothers and adolescents. Adolescent adjustment was assessed using standardised questionnaires. Systematic information on whether and when parents had told children about their biological origins was obtained at earlier phases of the study. There were no overall differences between disclosing families and either nondisclosing or natural conception families. However, within the disclosing families, more positive family relationships and higher levels of adolescent wellbeing were found for adolescents who had been told about their biological origins before age 7. The earlier children born through reproductive donation are told about their biological origins, the more positive are the outcomes in terms of the quality of family relationships and psychological wellbeing at adolescence. © 2016 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

  15. Trajectories of Verbal Episodic Memory in Middle-Aged and Older Adults: Evidence from the English Longitudinal Study of Ageing.

    Science.gov (United States)

    Olaya, Beatriz; Bobak, Martin; Haro, Josep Maria; Demakakos, Panayotes

    2017-06-01

    To identify distinct latent groups of baseline levels and age-related decline in verbal episodic memory in middle-aged and older adults, and to identify factors associated with these trajectories. Longitudinal study of six data collections over a period of 10 years. Population-based cohort in England. 9,515 community-dwelling adults aged 50-79 years. Six repeated measurements of immediate and delayed recall of 10 words over 10-year follow-up. Group-based trajectory modeling was used to identify patterns of baseline levels and subsequent decline in memory in two age categories (50-64 and 65-79 years), and to investigate associations between trajectories and baseline predictors of group membership (gender, education, household wealth, marital status, smoking and physical activity) and time-varying covariates (depressive symptoms and number of chronic conditions). Four trajectories were identified and labelled according to baseline status and decline in memory: very low/decline (9.8%), low/stable (40.2%), average/stable (39.5%) and good/stable (10.5%) in the younger group, and very low/rapid decline (15.7%), low/decline (32.0%), average/stable (38.8%), and good/stable (13.5%) in older participants. In people with stable or declining trajectories, a higher number of depressive symptoms and the presence of cardiovascular diseases were associated with worse memory. Female sex, younger age, and higher education, wealth and physical activity were consistently associated with more favourable trajectories. We identified four memory trajectories. Factors known to be associated with cognitive reserve (such as education, wealth and physical activity) were associated with better memory function while depressive symptoms and cardiovascular disease were associated with poorer memory. This suggests that interventions to reduce depressive symptoms and better manage cardiovascular risk factors and disease in midlife may help prevent or delay future memory decline. © 2017, Copyright

  16. Looking Very Old Age in the Eye: A Nuanced Approach to the Fourth Age in Contemporary Irish Fiction: A Case Study.

    Science.gov (United States)

    Zamorano Llena, Carmen

    2018-04-21

    Associations of young-old age with successful aging have contributed to relegating negatively perceived aspects of aging to very old age. This has prompted the formation of the social imaginary of the fourth age. Re-examinations of the fourth age foreground the diversity of aging experiences among the oldest old. In this sense, literature is in a privileged position to contribute individual narratives of aging to this field. The main aim of this article is to analyze Irish writer Jennifer Johnston's later fiction and how particularly two of her later fictional works contribute a nuanced re-examination of the fourth age through the narrativization of individual aging experiences of the oldest old in the contemporary Irish context. The work of sociologists and social theorists on re-examinations of the fourth age functions as the framework to analyze the selected fictional texts. The analysis of the oldest old characters in Truth or Fiction and Naming the Stars shows the contribution of literary texts to rethinking the fourth age as a time characterized by the inextricable combination of gains and losses, with emphasis on the diversity of the aging experiences of the oldest old and on the importance of sociocultural influence on individual aging. Combining longitudinal analyses with case studies, such as the ones suggested by these fictional texts, can provide a more accurate knowledge of the experience of advanced old age and the fourth age.

  17. Pilot studies of management of ageing of nuclear power plant instrumentation and control components

    International Nuclear Information System (INIS)

    Burnay, S.G.; Simola, K.; Kossilov, A.; Pachner, J.

    1993-01-01

    This paper describes pilot studies which have been implemented to study the aging behavior of safety related component parts of nuclear power plants. In 1989 the IAEA initiated work on pilot studies related to the aging of such components. Four components were identified for study. They are the primary nozzle of a reactor vessel; a motor operated isolating valve; the concrete containment building; and instrumentation and control cables within the containment facility. The study was begun with phase 1 efforts directed toward understanding the aging process, and methods for monitoring and minimizing the effects of aging. Phase 2 efforts are directed toward aging studies, documentation of the ideas put forward, and research to answer questions identified in phase 1. This paper describes progress made on two of these components, namely the motor operated isolation valves, and in-containment I ampersand C cables

  18. Defining and Estimating Healthy Aging in Spain: A Cross-sectional Study.

    Science.gov (United States)

    Rodriguez-Laso, Angel; McLaughlin, Sara J; Urdaneta, Elena; Yanguas, Javier

    2018-03-19

    Using an operational continuum of healthy aging developed by U.S. researchers, we sought to estimate the prevalence of healthy aging among older Spaniards, inform the development of a definition of healthy aging in Spain, and foster cross-national research on healthy aging. The ELES pilot study is a nationwide, cross-sectional survey of community-dwelling Spaniards 50 years and older. The prevalence of healthy aging was calculated for the 65 and over population using varying definitions. To evaluate their validity, we examined the association of healthy aging with the 8 foot up & go test, quality of life scores and self-perceived health using multiple linear and logistic regression. The estimated prevalence of healthy aging varied across the operational continuum, from 4.5% to 49.2%. Prevalence figures were greater for men and those aged 65 to 79 years and were higher than in the United States. Predicted mean physical performance scores were similar for 3 of the 4 definitions, suggesting that stringent definitions of healthy aging offer little advantage over a more moderate one. Similar to U.S. researchers, we recommend a definition of healthy aging that incorporates measures of functional health and limiting disease as opposed to definitions requiring the absence of all disease in studies designed to assess the effect of policy initiatives on healthy aging.

  19. MOD-AGE - an algorithm for age-depth model construction; U-series dated speleothems case study

    Science.gov (United States)

    Hercman, H.; Pawlak, J.

    2012-04-01

    We present MOD-AGE - a new system for chronology construction. MOD-AGE can be used for profiles that have been dated by different methods. As input data, the system uses the following basic measurements: activities, atomic ratios or age, as well as depth measurement. Based on probability distributions describing the measurement results, MOD-AGE estimates the age~depth relation and its confidence bands. To avoid the use of difficult-to-meet assumptions, MOD-AGE uses nonparametric methods. We applied a Monte Carlo simulation to model age and depth values based on the real distribution of counted data (activities, atomic ratios, depths etc.). Several fitting methods could be applied for estimating the relationships; based on several tests, we decide to use LOESS method (locally weighted scatterplot smoothing). The stratigraphic correction procedure applied in the MOD-AGE program uses a probability calculus, which assumes that the ages of all the samples are correctly estimated. Information about the probability distribution of the samples' ages is used to estimate the most probable sequence that is concordant according to the superposition rule. MOD-AGE is presented as a tool for the chronology construction of speleothems that have been analyzed by the U-series method, and it is compared to the StalAge algorithm presented by D. Scholtz and D.L Hoffmann (2011). Scholtz, D., Hoffmann, D. L., 2011. StalAge - An algorithm designed for construction of speleothem age models. Quaternary Geochronology 6, 369-382.

  20. Internet Use and Psychological Well-Being at Advanced Age: Evidence from the English Longitudinal Study of Aging

    Directory of Open Access Journals (Sweden)

    David Quintana

    2018-03-01

    Full Text Available This work explores the connection between psychological well-being and Internet use in older adults. The study is based on a sample of 2314 participants in the English Longitudinal Study of Aging. The subjects, aged 50 years and older, were interviewed every two years over the 2006–2007 to 2014–2015 period. The connection between the use of Internet/Email and the main dimensions of psychological well-being (evaluative, hedonic and eudaimonic was analyzed by means of three generalized estimating equation models that were fitted on 2-year lagged repeated measurements. The outcome variables, the scores on three well-being scales, were explained in terms of Internet/Email use, controlling for covariates that included health and socioeconomic indicators. The results support the existence of a direct relationship between Internet/Email use and psychological well-being. The connection between the main predictor and the score of the participants on the scale used to measure the eudaimonic aspect was positive and statistically significant at conventional levels (p-value: 0.015. However, the relevance of digital literacy on the evaluative and the hedonic components could not be confirmed (p-values for evaluative and hedonic dimensions were 0.078 and 0.192, respectively.

  1. Does age impact self-actualization needs?—an empirical study ...

    African Journals Online (AJOL)

    Thus, although this study supports the existence of needs, the chronology of their dominance may not be as per Maslow's hierarchy pyramid. This empirical study establishes that there may not be progressive increase in self-actualization need as age progresses. Keywords: Maslow, need priorities, age, self-actualization ...

  2. Rumination, Age, and Years of Experience: A Predictive Study of Burnout

    Science.gov (United States)

    McDuffy, Moriel S.

    2016-01-01

    This study used a non-experimental design to examine whether job satisfaction, rumination, age and years of experience predict burnout among human service workers serving high-risk populations. The study also used a stepwise regression to assess whether job satisfaction, rumination, age, or years of experience predict burnout equally. Burnout was…

  3. Dietary quality, lifestyle factors and healthy ageing in Europe: the SENECA study

    NARCIS (Netherlands)

    Haveman-Nies, A.; Groot, de C.P.G.M.; Staveren, van W.A.

    2003-01-01

    Objective: to identify dietary and lifestyle factors that contribute to healthy ageing. Subjects: for the analyses, data of the longitudinal SENECA study were used. The study population consisted of 1091 men and 1109 women aged 70-75 years from Belgium, France, Denmark, Italy, The Netherlands,

  4. The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.

    Science.gov (United States)

    Treuting, P M; Snyder, J M; Ikeno, Y; Schofield, P N; Ward, J M; Sundberg, J P

    2016-03-01

    Pathology is a discipline of medicine that adds great benefit to aging studies of rodents by integrating in vivo, biochemical, and molecular data. It is not possible to diagnose systemic illness, comorbidities, and proximate causes of death in aging studies without the morphologic context provided by histopathology. To date, many rodent aging studies do not utilize end points supported by systematic necropsy and histopathology, which leaves studies incomplete, contradictory, and difficult to interpret. As in traditional toxicity studies, if the effect of a drug, dietary treatment, or altered gene expression on aging is to be studied, systematic pathology analysis must be included to determine the causes of age-related illness, moribundity, and death. In this Commentary, the authors discuss the factors that should be considered in the design of aging studies in mice, with the inclusion of robust pathology practices modified after those developed by toxicologic and discovery research pathologists. Investigators in the field of aging must consider the use of histopathology in their rodent aging studies in this era of integrative and preclinical geriatric science (geroscience). © The Author(s) 2016.

  5. Old age and forgoing treatment: a nationwide mortality follow-back study in the Netherlands

    NARCIS (Netherlands)

    Martins Pereira, S.; Pasman, H.R.W.; Heide, A.; van Delden, J.J.M.; Onwuteaka-Philipsen, B.D.

    2015-01-01

    Background The ageing of the population raises the need to study forgoing treatment decisions among older people. Aim To describe the incidence and decision-making of forgoing treatment and identify age-related differences. Methods A nationwide study of a stratified sample from the Statistics

  6. Old age and forgoing treatment : a nationwide mortality follow-back study in the Netherlands

    NARCIS (Netherlands)

    Pereira, Sandra Martins; Pasman, H. Roeline; van der Heide, Agnes; van Delden, Johannes J. M.; Onwuteaka-Philipsen, Bregje D.

    Background The ageing of the population raises the need to study forgoing treatment decisions among older people. Aim To describe the incidence and decision-making of forgoing treatment and identify age-related differences. Methods A nationwide study of a stratified sample from the Statistics

  7. Comparison of menarche age between two generations (tehran lipid and glucose study)

    International Nuclear Information System (INIS)

    Ainy, E.; Aziz, F.

    2007-01-01

    Menarcheal age is considered to be an indicator of puberty. There is a lack of information on menarcheal age in Tehranian girls, in comparison to that of their mothers. This cross-sectional study was aimed at comparing the age of menarches between two generations. The subjects were 812 (406 daughters and 406 mothers) chosen from among 15005 participants of the longitudinal Tehran Lipid and Glucose Study. Demographic information and the age of menarche were recorded in a questionnaire. We have considered a minimal of 25 years duration to be one generation. Distribution of the menarcheal age and linear regression were performed. The mean age of menarche in daughters and their mothers were 13.2+-1.4 and 13.6+-1.5 years, respectively. There was significant correlation between the mother and daughter menarcheal age (r=0.25, P<0.002). 25th, 50th and 75th percentiles for menarcheal ages in daughters and their mothers were 12.2, 13.1, 14.1 and 12.7, 13.5, 14.5 years respectively. Minimum and maximum ages of menarche were the same (10 and 18 years) in the two groups. We found a decrease in the average menarcheal age during 25 years (one generation) similar to the results of other studies. (author)

  8. Internet use and the digital divide in the English longitudinal study of ageing.

    Science.gov (United States)

    Gilleard, Chris; Higgs, Paul

    2008-09-01

    This paper examines the digital divide in Internet use in later life. We hypothesise that the differential diffusion of domestic information and communication technologies between pre- and post-Second World War cohorts is primarily responsible for this divide rather than either age-associated structural inequalities or age-related intrinsic features of mental and/or physical infirmity. Using data from the English Longitudinal Study of Ageing we show that age/cohort differences in Internet use persist after income, education, employment and health status are controlled for. However, when engagement with domestic information and communication technology and cultural activities are taken into account, age/cohort influences on Internet use decline. These contingent 'age/cohort' effects suggest that 'generational' rather than 'structural' or 'stage of life' influences may be more salient explanations of the (age-based) digital divide.

  9. Gestational Age at Birth and 'Body-Mind' Health at 5 Years of Age: A Population Based Cohort Study.

    Directory of Open Access Journals (Sweden)

    Frances M Cronin

    Full Text Available Numerous studies have identified the effects of prematurity on the neonate's physical health, however few studies have explored the effects of prematurity on both the physical and mental health of the child as they develop. Secondary analysis of data from the Millennium Cohort Study, a longitudinal study of infants (n = 18 818, born 2000-2002 in the United Kingdom was performed. Effects of gestational age at birth on health outcomes at 5 years were measured using parental rating of their children's general health and severity of behavior problems. The association between parent's general health ratings and behavior problem ratings was low: 86% of those reporting serious behavior problems (5% of the sample, n = 764 rated their child as being in excellent, very good, or good health. Still, a gradient of increasing risk of poorer outcome with decreasing gestational age was observed for a composite health measure (poor/fair health and/or serious behavior problems, suggesting an association with prematurity for this composite assessment of health status. The greatest contribution to the childhood composite health measure at 5 years was for children born at 32-36 weeks gestation: population attributable fractions for having poor outcomes was 3.4% (Bonferroni-adjusted 95% confidence interval 1.1%-6.2%, compared to 1% (0.2-2.3 for birth at less than 32 weeks. Results suggest that preterm children, by school entry, are not only at high risk of physical health problems, but also of behavioral health problems. The recognition of, and response to comprehensive health and well-being outcomes related to prematurity are important in order to correctly plan and deliver adequate paediatric health services and policies.

  10. Gestational Age at Birth and 'Body-Mind' Health at 5 Years of Age: A Population Based Cohort Study.

    Science.gov (United States)

    Cronin, Frances M; Segurado, Ricardo; McAuliffe, Fionnuala M; Kelleher, Cecily C; Tremblay, Richard E

    2016-01-01

    Numerous studies have identified the effects of prematurity on the neonate's physical health, however few studies have explored the effects of prematurity on both the physical and mental health of the child as they develop. Secondary analysis of data from the Millennium Cohort Study, a longitudinal study of infants (n = 18 818, born 2000-2002 in the United Kingdom) was performed. Effects of gestational age at birth on health outcomes at 5 years were measured using parental rating of their children's general health and severity of behavior problems. The association between parent's general health ratings and behavior problem ratings was low: 86% of those reporting serious behavior problems (5% of the sample, n = 764) rated their child as being in excellent, very good, or good health. Still, a gradient of increasing risk of poorer outcome with decreasing gestational age was observed for a composite health measure (poor/fair health and/or serious behavior problems), suggesting an association with prematurity for this composite assessment of health status. The greatest contribution to the childhood composite health measure at 5 years was for children born at 32-36 weeks gestation: population attributable fractions for having poor outcomes was 3.4% (Bonferroni-adjusted 95% confidence interval 1.1%-6.2%), compared to 1% (0.2-2.3) for birth at less than 32 weeks. Results suggest that preterm children, by school entry, are not only at high risk of physical health problems, but also of behavioral health problems. The recognition of, and response to comprehensive health and well-being outcomes related to prematurity are important in order to correctly plan and deliver adequate paediatric health services and policies.

  11. Gestational Age at Birth and 'Body-Mind' Health at 5 Years of Age: A Population Based Cohort Study.

    LENUS (Irish Health Repository)

    Cronin, Frances M

    2016-01-01

    Numerous studies have identified the effects of prematurity on the neonate\\'s physical health, however few studies have explored the effects of prematurity on both the physical and mental health of the child as they develop. Secondary analysis of data from the Millennium Cohort Study, a longitudinal study of infants (n = 18 818, born 2000-2002 in the United Kingdom) was performed. Effects of gestational age at birth on health outcomes at 5 years were measured using parental rating of their children\\'s general health and severity of behavior problems. The association between parent\\'s general health ratings and behavior problem ratings was low: 86% of those reporting serious behavior problems (5% of the sample, n = 764) rated their child as being in excellent, very good, or good health. Still, a gradient of increasing risk of poorer outcome with decreasing gestational age was observed for a composite health measure (poor\\/fair health and\\/or serious behavior problems), suggesting an association with prematurity for this composite assessment of health status. The greatest contribution to the childhood composite health measure at 5 years was for children born at 32-36 weeks gestation: population attributable fractions for having poor outcomes was 3.4% (Bonferroni-adjusted 95% confidence interval 1.1%-6.2%), compared to 1% (0.2-2.3) for birth at less than 32 weeks. Results suggest that preterm children, by school entry, are not only at high risk of physical health problems, but also of behavioral health problems. The recognition of, and response to comprehensive health and well-being outcomes related to prematurity are important in order to correctly plan and deliver adequate paediatric health services and policies.

  12. Effect of women's age on embryo morphology, cleavage rate and competence-A multicenter cohort study

    DEFF Research Database (Denmark)

    Grøndahl, Marie Louise; Christiansen, Sofie Lindgren; Kesmodel, Ulrik Schiøler

    2017-01-01

    This multicenter cohort study on embryo assessment and outcome data from 11,744 IVF/ICSI cycles with 104,830 oocytes and 42,074 embryos, presents the effect of women's age on oocyte, zygote, embryo morphology and cleavage parameters, as well as cycle outcome measures corrected for confounding.......0001) with increasing age. Maternal age had no effect on cleavage parameters or on the morphology of the embryo day 2 post insemination. Interestingly, initial hCG value after single embryo transfer followed by ongoing pregnancy was increased with age in both IVF (p = 0.007) and ICSI (p = 0.001) cycles. For the first...... time, we show that a woman's age does impose a significant footprint on early embryo morphological development (3PN). In addition, the developmentally competent embryos were associated with increased initial hCG values as the age of the women increased. Further studies are needed to elucidate...

  13. Aging effects on cerebral asymmetry: a voxel-based morphometry and diffusion tensor imaging study.

    Science.gov (United States)

    Takao, Hidemasa; Abe, Osamu; Yamasue, Hidenori; Aoki, Shigeki; Kasai, Kiyoto; Sasaki, Hiroki; Ohtomo, Kuni

    2010-01-01

    The hemispheres of the human brain are functionally and structurally asymmetric. The purpose of this study was to evaluate the effects of aging on gray and white matter asymmetry. Two hundred twenty-six right-handed normal volunteers aged 21-71 years were included in this study. The effects of aging on gray matter volume asymmetry and white matter fractional anisotropy asymmetry were evaluated with use of voxel-based morphometry and voxel-based analysis of fractional anisotropy maps derived from diffusion tensor imaging (DTI), respectively. The voxel-based morphometry showed no significant correlation between age and gray matter volume asymmetry. The voxel-based analysis of DTI also showed no significant correlation between age and white matter fractional anisotropy asymmetry. Our results showed no significant effects of aging on either gray matter volume asymmetry or white matter fractional anisotropy asymmetry.

  14. Prediction of BMI at age 11 in a longitudinal sample of the Ulm Birth Cohort Study.

    Directory of Open Access Journals (Sweden)

    Hanna Christiansen

    Full Text Available Obesity is one of the greatest public health challenges in the world with childhood prevalence rates between 20-26% and numerous associated health risks. The aim of the current study was to analyze the 11-year follow-up data of the Ulm Birth Cohort Study (UBCS, to identify whether abnormal eating behavior patterns, especially restrained eating, predict body mass index (BMI at 11 years of age and to explore other factors known to be longitudinally associated with it. Of the original UBCS, n = 422 children (~ 40% of the original sample and their parents participated in the 11-year follow-up. BMI at age 8 and 11 as well as information on restrained eating, psychological problems, depressive symptoms, lifestyle, and IQ at age 8 were assessed. Partial Least Squares Structural Equation Modeling (PLS-SEM was used to predict children's BMI scores at age 11. PLS-SEM explained 68% of the variance of BMI at age 11, with BMI at age 8 being the most important predictor. Restrained eating, via BMI at age 8 as well as parental BMI, had further weak associations with BMI at age 11; no other predictor was statistically significant. Since established overweight at age 8 already predicts BMI scores at age 11 longitudinally, obesity interventions should be implemented in early childhood.

  15. 40Ar-39Ar age studies for tectonics of the Gondwana land

    International Nuclear Information System (INIS)

    Takigami, Yutaka; Sugiura, Naoji.

    1997-01-01

    40 Ar- 39 Ar age studies have been performed for samples from Antarctica and India which were parts of the Gondwana land at Mesozoic and Paleozoic time in order to investigate their thermal history and tectonic movement. From the both areas, ages of about 500 Ma which have been considered to be the age of Pan-African Orogeny were obtained, which represents that this thermal event spread widely over the Gondwana land. (author)

  16. Prevalence and correlates of successful ageing: a comparative study between China and South Korea.

    Science.gov (United States)

    Feng, Qiush; Son, Joonmo; Zeng, Yi

    2015-06-01

    Successful ageing is often defined as a later life with less disease and disease-related disability, high level of cognitive and physical functions, and an active life style. Few studies have compared successful ageing across different societies in a non-Western social context. This study aims to compare prevalence and correlates of successful ageing between China and South Korea. The data come from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the Korean Longitudinal Study of Ageing (KLoSA). A total of 19,346 community-dwelling elders over 65 years were included, 15,191 from China and 4,155 from Korea. A multidimensional construct of successful ageing was used, with the criteria of no major comorbidity, being free of disability, good mental health, engaging in social or productive activity, and satisfaction on life. Correlates of successful ageing included demographics (gender, age, and rural/urban residence), socioeconomic features (financial status, education, and spouse accompany), and health behaviours (smoking, alcohol-drinking, and exercising). The results showed that 18.6 % of the older adults in China was successful agers, which was less than 25.2 % in Korea. When gender and age were adjusted, older adults were 51 % less likely to be successful agers in China than Korea ( p  Korea. However, before the socioeconomic variables are under control, rural residence was negatively related to successful ageing in China, whereas this is not the case in Korea. And the gender gap of successful ageing was mostly explained by socioeconomic features and health behaviours in Korea, but not in China. In both countries, good financial condition was highly associated with successful ageing. The study suggests that advancement of public health system could better control progression of non-communicable diseases among old people and thus promote successful ageing.

  17. Age-related changes in the macula. A histopathological study of fifty Indian donor eyes

    OpenAIRE

    Biswas Jyotirmay; Raman Rajiv

    2002-01-01

    PURPOSE: Age-related macular degeneration (ARMD) is clinically less common in India compared to the West. Therefore, clinicians are unfamiliar with histopathologic evidence of age-related macular changes in the Indian population. METHODS: Fifty consecutive human donor eyes removed for corneal grafting were studied for gross, microscopic and histochemical features of age-related changes in the macula in the Indian population. A horizontal block was cut from the globe including the optic disc, ...

  18. ^<40>Ar-^<39>Ar Age Studies for Tectonics of the Gondwana Land

    OpenAIRE

    Takigami, Yutaka; Sugiura, Naoji

    1997-01-01

    ^Ar-^Ar age studies have been performed for samples from Antarctica and India which were parts of the Gondwana land at Mesozoic and Paleozoic time in order to investigate their thermal history and tectonic movement. From the both areas, ages of about 500 Ma which have been considered to be the age of Pan-African Orogeny were obtained, which represents that this thermal event spread widely over the Gondwana land.

  19. The Relationship of Korean Students' Age and Years of English-as-a-Foreign-Language Exposure with English-Reading Ability: A Cross-Age Study

    Science.gov (United States)

    Fitzgerald, Jill; Stenner, A. Jackson; Sanford-Moore, Eleanor E.; Koons, Heather; Bowen, Kimberly; Kim, Kee Hyung

    2015-01-01

    The purpose of the present cross-age study with South Korean students was to investigate the relationship of age and years of English-as-a-foreign-language (EFL) exposure with English-reading ability. The main research question was, "Do individuals' age and number of years of English exposure interact in relation to English-reading…

  20. The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda.

    Science.gov (United States)

    Moffitt, Terrie E; Belsky, Daniel W; Danese, Andrea; Poulton, Richie; Caspi, Avshalom

    2017-02-01

    To prevent onset of age-related diseases and physical and cognitive decline, interventions to slow human aging and extend health span must eventually be applied to people while they are still young and healthy. Yet most human aging research examines older adults, many with chronic disease, and little is known about aging in healthy young humans. This article explains how this knowledge gap is a barrier to extending health span and puts forward the case that geroscience should invest in researching the pace of aging in young adults. As one illustrative example, we describe an initial effort to study the pace of aging in a young-adult birth cohort by using repeated waves of biomarkers collected across the third and fourth decades to quantify the pace of coordinated physiological deterioration across multiple organ systems (eg, pulmonary, periodontal, cardiovascular, renal, hepatic, metabolic, and immune function). Findings provided proof of principle that it is possible to quantify individual variation in the pace of aging in young adults still free of age-related diseases. This article articulates research needs to improve longitudinal measurement of the pace of aging in young people, to pinpoint factors that slow or speed the pace of aging, to compare pace of aging against genomic clocks, to explain slow-aging young adults, and to apply pace of aging in preventive clinical trials of antiaging therapies. This article puts forward a research agenda to fill the knowledge gap concerning lifelong causes of aging. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Corneal clarity measurements in healthy volunteers across different age groups: Observational study.

    Science.gov (United States)

    Alzahrani, Khaled; Carley, Fiona; Brahma, Arun; Morley, Debbie; Hillarby, M Chantal

    2017-11-01

    The aim of this study was to standardize and investigate the changes in corneal clarity with age. Densitometry software for the Oculus Pentacam was used to examine corneal clarity at different age groups.A total of 192 eyes from 97 healthy participants were included in this cohort comparative nonrandomized, cross-sectional study. An Oculus Pentcam was used to image the cornea of healthy participants grouped by age (between 10 and 70 years old). Data from the densitometry output have been used to determine clarity in concentric zones and different depths of the cornea.Corneal densitometry (CD) across all ages showed significant differences between groups when divided into the following layers: anterior, central, and posterior or divided into 0 to 2, 2 to 6, and 6 to 10 mm concentric zones (P age in all 3 layers of the periphery (6-10 mm) (P age group had lower clarity than the 20 to 30-age group (P age is differed when the cornea is divided into layers and zones. This study suggests that there are other factors that may play an essential role in corneal clarity as well as age.

  2. [MESGI50 study: description of a cohort on Maturity and Satisfactory Ageing].

    Science.gov (United States)

    Corominas Barnadas, Josep María; López-Pousa, Secundino; Vilalta-Franch, Joan; Calvó-Perxas, Laia; Juvinyà Canal, Dolors; Garre-Olmo, Josep

    To describe the demographic, health and socio-economic characteristics of the participants in the Study on Maturity and Satisfactory Ageing in Girona (MESGI50 study). Population-based Study linked to the Survey of Health, Ageing, and Retirement in Europe (SHARE). The reference population was the inhabitants of the province of Girona (Spain) aged 50 and over. A probabilistic two-stage stratified cluster sampling according to the number of inhabitants and the degree of ageing of the population was used. Twenty-eight municipalities were randomly selected according to their type (demographically aged or young), and then stratified by the population size. The response rate was 65% with a mean of 1.7 eligible individuals per household and a final sample of 2,065 households and 3,331 participants. The design effect was 1.27. 52.9% were women and the mean age was 66.9 years (SD=11.5). The self-rated health status, hand grip strength, restriction in daily life activities and depressive symptomatology increased with age and more markedly in women. There were differences in alcohol consumption and eating patterns depending on the area of residence. The demographic, health and socio-economic characteristics during the ageing process differ depending on age group, gender, and area of residence. Copyright © 2016 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  3. Age differences in adults' daily social interactions: An ecological momentary assessment study.

    Science.gov (United States)

    Zhaoyang, Ruixue; Sliwinski, Martin J; Martire, Lynn M; Smyth, Joshua M

    2018-04-30

    Prevailing research has suggested that social relationships get better with age, but this evidence has been largely based on studies with lengthy reporting intervals. Using an ecological momentary assessment approach, the present study examined age differences in several characteristics of social interactions as reported in near-real time: the frequency, quality, and partner type. Participants (N = 173) ages 20-79 years reported their social interactions at 5 random times throughout the day for 1 week. Results revealed that age was associated with higher frequency of interacting with family and lower frequency of interacting with peripheral partners. These age effects, however, became nonsignificant after accounting for contextual factors such as race, gender, education, employment status, family structure, and living arrangement. In contrast, a curvilinear relationship best characterized age differences in both positive and negative ratings of daily social interaction quality, with middle-aged adults reporting the lowest positive ratings and older adults reporting the lowest negative ratings among all ages. Contextual factors did not account for these patterns of age differences in interaction quality. Furthermore, the intraindividual variability of interaction frequency with peripheral partners, partner diversity, and interaction quality (positivity and negativity) was lower among older adults than among younger adults. Findings from the present study portray a nuanced picture of social interactions in daily life and advance the understanding of social interactions across the life span. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  4. Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study

    Science.gov (United States)

    Allerhand, Michael; Eadie, Elizabeth; Thomas, Avril; Corley, Janey; Pattie, Alison; Taylor, Adele; Shenkin, Susan D; Cox, Simon; Gow, Alan; Starr, John M; Deary, Ian J

    2016-01-01

    Cognitive decline and carotid artery atheroma are common at older ages. In community-dwelling subjects, we assessed cognition at ages 70, 73 and 76 and carotid Doppler ultrasound at age 73, to determine whether carotid stenosis was related to cognitive decline. We used latent growth curve models to examine associations between four carotid measures (internal carotid artery stenosis, velocity, pulsatility and resistivity indices) and four cognitive ability domains (memory, visuospatial function, crystallised intelligence, processing speed) adjusted for cognitive ability at age 11, current age, gender and vascular risk factors. Amongst 866 participants, carotid stenosis (median 12.96%) was not associated with cognitive abilities at age 70 or cognitive decline from age 70 to 76. Increased ICA pulsatility and resistivity indices were associated with slower processing speed (both P function (P = 0.036, 0.031, respectively) at age 70, and declining crystallised intelligence from ages 70 to 76 (P = 0.008, 0.006, respectively). The findings suggest that vascular stiffening, rather than carotid luminal narrowing, adversely influences cognitive ageing and provides a potential target for ameliorating age-related cognitive decline. PMID:28155579

  5. Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study.

    Science.gov (United States)

    Wardlaw, Joanna M; Allerhand, Michael; Eadie, Elizabeth; Thomas, Avril; Corley, Janey; Pattie, Alison; Taylor, Adele; Shenkin, Susan D; Cox, Simon; Gow, Alan; Starr, John M; Deary, Ian J

    2017-08-01

    Cognitive decline and carotid artery atheroma are common at older ages. In community-dwelling subjects, we assessed cognition at ages 70, 73 and 76 and carotid Doppler ultrasound at age 73, to determine whether carotid stenosis was related to cognitive decline. We used latent growth curve models to examine associations between four carotid measures (internal carotid artery stenosis, velocity, pulsatility and resistivity indices) and four cognitive ability domains (memory, visuospatial function, crystallised intelligence, processing speed) adjusted for cognitive ability at age 11, current age, gender and vascular risk factors. Amongst 866 participants, carotid stenosis (median 12.96%) was not associated with cognitive abilities at age 70 or cognitive decline from age 70 to 76. Increased ICA pulsatility and resistivity indices were associated with slower processing speed (both P < 0.001) and worse visuospatial function ( P = 0.036, 0.031, respectively) at age 70, and declining crystallised intelligence from ages 70 to 76 ( P = 0.008, 0.006, respectively). The findings suggest that vascular stiffening, rather than carotid luminal narrowing, adversely influences cognitive ageing and provides a potential target for ameliorating age-related cognitive decline.

  6. Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population.

    Science.gov (United States)

    Pyun, Jung-A; Kim, Sunshin; Cho, Nam H; Koh, InSong; Lee, Jong-Young; Shin, Chol; Kwack, KyuBum

    2014-05-01

    The aim of this study was to identify polymorphisms and gene-gene interactions that are significantly associated with age at menarche and age at menopause in a Korean population. A total of 3,452 and 1,827 women participated in studies of age at menarche and age at natural menopause, respectively. Linear regression analyses adjusted for residence area were used to perform genome-wide association studies (GWAS), candidate gene association studies, and interactions between the candidate genes for age at menarche and age at natural menopause. In GWAS, four single nucleotide polymorphisms (SNPs; rs7528241, rs1324329, rs11597068, and rs6495785) were strongly associated with age at natural menopause (lowest P = 9.66 × 10). However, GWAS of age at menarche did not reveal any strong associations. In candidate gene association studies, SNPs with P menopause, there was a significant interaction between intronic SNPs on ADAM metallopeptidase with thrombospondin type I motif 9 (ADAMTS9) and SMAD family member 3 (SMAD3) genes (P = 9.52 × 10). For age at menarche, there were three significant interactions between three intronic SNPs on follicle-stimulating hormone receptor (FSHR) gene and one SNP located at the 3' flanking region of insulin-like growth factor 2 receptor (IGF2R) gene (lowest P = 1.95 × 10). Novel SNPs and synergistic interactions between candidate genes are significantly associated with age at menarche and age at natural menopause in a Korean population.

  7. A Cross-Sectional Study of Ageing and Cardiovascular Function over the Baboon Lifespan.

    Directory of Open Access Journals (Sweden)

    Kristen R Yeung

    Full Text Available Ageing is associated with changes at the molecular and cellular level that can alter cardiovascular function and ultimately lead to disease. The baboon is an ideal model for studying ageing due to the similarities in genetic, anatomical, physiological and biochemical characteristics with humans. The aim of this cross-sectional study was to investigate the changes in cardiovascular profile of baboons over the course of their lifespan.Data were collected from 109 healthy baboons (Papio hamadryas at the Australian National Baboon Colony. A linear regression model, adjusting for sex, was used to analyse the association between age and markers of ageing with P 12 years had significantly shorter telomeres when compared to younger (<3 years baboons (P = 0.001.This study is the first to demonstrate that cardiovascular function alters with age in the baboon. This research identifies similarities within cardiovascular parameters between humans and baboon even though the length of life differs between the two species.

  8. Building and commissioning of a setup to study ageing phenomena in gaseous detectors

    International Nuclear Information System (INIS)

    Abuhoza, A.; Schmidt, H.R.; Biswas, S.; Frankenfeld, U.; Hehner, J.; Schmidt, C.J.

    2016-01-01

    In high-rate heavy-ion experiments, gaseous detectors encounter big challenges in terms of degradation of their performance due to a phenomenon called ageing. A setup for high precision ageing studies has been constructed and commissioned at the GSI detector laboratory. The setup as well as the gas system have been carefully optimized to reach a high sensitivity for ageing effects. Two different materials have been examined for their influence on gaseous detectors: RTV-3145 and Gerband 705. The details of the construction of the ageing test setup and the test results will be presented.

  9. Building and commissioning of a setup to study ageing phenomena in gaseous detectors

    Energy Technology Data Exchange (ETDEWEB)

    Abuhoza, A., E-mail: aabuhoza@kacst.edu.sa [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt 64291 (Germany); King Abdulaziz City for Science and Technology (KACST), Riyadh (Saudi Arabia); Goethe-Universität, Frankfurt (Germany); Schmidt, H.R. [Eberhard-Karls-Universität, Tübingen (Germany); Biswas, S. [School of Physical Sciences, National Institute of Science Education and Research, Jatni 752050 (India); Frankenfeld, U.; Hehner, J.; Schmidt, C.J. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt 64291 (Germany)

    2016-07-11

    In high-rate heavy-ion experiments, gaseous detectors encounter big challenges in terms of degradation of their performance due to a phenomenon called ageing. A setup for high precision ageing studies has been constructed and commissioned at the GSI detector laboratory. The setup as well as the gas system have been carefully optimized to reach a high sensitivity for ageing effects. Two different materials have been examined for their influence on gaseous detectors: RTV-3145 and Gerband 705. The details of the construction of the ageing test setup and the test results will be presented.

  10. Applied dendroecology and environmental forensics. Characterizing and age dating environmental releases: fundamentals and case studies

    Science.gov (United States)

    Jean-Christophe Balouet; Gil Oudijk; Kevin T. Smith; Ioana Petrisor; Hakan Grudd; Bengt. Stocklassa

    2007-01-01

    Dendroecology, or the use of ring patterns to assess the age of trees and environmental factors controlling their growth, is a well-developed method in climatologic studies. This method holds great potential as a forensic tool for age dating, contamination assessment, and characterization of releases. Moreover, the method is independent of the physical presence of...

  11. Contribution of NIRS to the Study of Prefrontal Cortex for Verbal Fluency in Aging

    Science.gov (United States)

    Kahlaoui, Karima; Di Sante, Gabriele; Barbeau, Joannie; Maheux, Manon; Lesage, Frederic; Ska, Bernadette; Joanette, Yves

    2012-01-01

    Healthy aging is characterized by a number of changes on brain structure and function. Several neuroimaging studies have shown an age-related reduction in hemispheric asymmetry on various cognitive tasks, a phenomenon captured by Cabeza (2002) in the Hemispheric Asymmetry Reduction in Older Adults (HAROLD) model. Although this phenomenon is…

  12. Data resource profile: the World Health Organization Study on global AGEing and adult health (SAGE).

    Science.gov (United States)

    Kowal, Paul; Chatterji, Somnath; Naidoo, Nirmala; Biritwum, Richard; Fan, Wu; Lopez Ridaura, Ruy; Maximova, Tamara; Arokiasamy, Perianayagam; Phaswana-Mafuya, Nancy; Williams, Sharon; Snodgrass, J Josh; Minicuci, Nadia; D'Este, Catherine; Peltzer, Karl; Boerma, J Ties

    2012-12-01

    Population ageing is rapidly becoming a global issue and will have a major impact on health policies and programmes. The World Health Organization's Study on global AGEing and adult health (SAGE) aims to address the gap in reliable data and scientific knowledge on ageing and health in low- and middle-income countries. SAGE is a longitudinal study with nationally representative samples of persons aged 50+ years in China, Ghana, India, Mexico, Russia and South Africa, with a smaller sample of adults aged 18-49 years in each country for comparisons. Instruments are compatible with other large high-income country longitudinal ageing studies. Wave 1 was conducted during 2007-2010 and included a total of 34 124 respondents aged 50+ and 8340 aged 18-49. In four countries, a subsample consisting of 8160 respondents participated in Wave 1 and the 2002/04 World Health Survey (referred to as SAGE Wave 0). Wave 2 data collection will start in 2012/13, following up all Wave 1 respondents. Wave 3 is planned for 2014/15. SAGE is committed to the public release of study instruments, protocols and meta- and micro-data: access is provided upon completion of a Users Agreement available through WHO's SAGE website (www.who.int/healthinfo/systems/sage) and WHO's archive using the National Data Archive application (http://apps.who.int/healthinfo/systems/surveydata).

  13. Mediterranean Diet Score and Its Association with Age-Related Macular Degeneration : The European Eye Study

    NARCIS (Netherlands)

    Hogg, Ruth E; Woodside, Jayne V; McGrath, Alanna; Young, Ian S; Vioque, Jesus L; Chakravarthy, Usha; de Jong, Paulus T; Rahu, Mati; Seland, Johan; Soubrane, Gisele; Tomazzoli, Laura; Topouzis, Fotis; Fletcher, Astrid E

    2017-01-01

    PURPOSE: To examine associations between adherence to a Mediterranean diet and prevalence of age-related macular degeneration (AMD) in countries ranging from Southern to Northern Europe. DESIGN: Cross-sectional, population-based epidemiologic study. PARTICIPANTS: Of 5060 randomly sampled people aged

  14. Effects of Divorce on Children of Different Ages: A Descriptive Study.

    Science.gov (United States)

    Schwartz, Lita Linzer

    The impact of divorce on children seems to vary according to the child's age. Previous studies on the impact of divorce on children have generally focused on pre-schoolers and elementary-age children. Since more long-term marriages are ending in divorce, attention should also be given to adolescent and adult children of divorce. Subjects (N=26)…

  15. Age, intelligence, and event-related brain potentials during late childhood: A longitudinal study.

    NARCIS (Netherlands)

    Molenaar, P.C.M.; Molen, M.W.; Stauder, J.E.A.

    2003-01-01

    he relation between event-related brain activity, age, and intelligence was studied using a visual oddball task presented longitudinally to girls at 9, 10, and 11 years of age. The event-related brain potential (ERP) components showed typical gradual decrements in latency and amplitude with

  16. Incidence and progression rates of age-related maculopathy: the Rotterdam Study

    NARCIS (Netherlands)

    J.J.M. Willemse-Assink (Jacqueline); R. van Leeuwen (Redmer); R.C.W. Wolfs (Roger); J.R. Vingerling (Hans); Th. Stijnen (Theo); P.T.V.M. de Jong (Paulus); C.C.W. Klaver (Caroline); A. Hofman (Albert)

    2001-01-01

    textabstractPURPOSE: To describe the incidence rate of age-related macular degeneration (AMD) and the progression rates of early stages of age-related maculopathy (ARM), and to study the hierarchy of fundus features that determine progression. METHODS: A group of 4953 subjects

  17. Perceiving Age and Gender in Unfamiliar Faces: An fMRI Study on Face Categorization

    Science.gov (United States)

    Wiese, Holger; Kloth, Nadine; Gullmar, Daniel; Reichenbach, Jurgen R.; Schweinberger, Stefan R.

    2012-01-01

    Efficient processing of unfamiliar faces typically involves their categorization (e.g., into old vs. young or male vs. female). However, age and gender categorization may pose different perceptual demands. In the present study, we employed functional magnetic resonance imaging (fMRI) to compare the activity evoked during age vs. gender…

  18. The age-dependency of genetic and environmental influences on serum cytokine levels : A twin study

    NARCIS (Netherlands)

    Sas, Arthur A.; Jamshidi, Yalda; Zheng, Dongling; Wu, Ting; Korf, Jakob; Alizadeh, Behrooz Z.; Snieder, Harold; Spector, Timothy D.

    2012-01-01

    Previous epidemiologic studies have evaluated the use of immunological markers as possible tools for measuring ageing and predicting age-related pathology. The importance of both genetic and environmental influences in regulation of these markers has been emphasized. In order to further evaluate

  19. Cardiovascular risk factors associated with age-related macular degeneration: the Tromso Study

    DEFF Research Database (Denmark)

    Erke, M. G.; Bertelsen, G.; Peto, T.

    2014-01-01

    PurposeTo examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). MethodsA population-based, cross-sectional study of Caucasians aged 65-87years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic...

  20. Advanced paternal age and risk of fetal death: a cohort study

    DEFF Research Database (Denmark)

    Nybo Andersen, Anne-Marie; Hansen, Kasper Daniel; Andersen, Per Kragh

    2004-01-01

    Cohort from 1997 to 1999 to assess the association between paternal age and fetal death. Fathers of the pregnancies were identified by record linkage to population registers. The paternal age-related risks of fetal death and its components, early and late fetal loss, were estimated using survival......A possible detrimental paternal age effect on offspring health due to mutations of paternal origin should be reflected in an association between paternal age and fetal loss. The authors used data from a prospective study of 23,821 pregnant women recruited consecutively to the Danish National Birth...... analysis. Pregnancies fathered by a man aged 50 or more years (n = 124) had almost twice the risk of ending in a fetal loss compared with pregnancies with younger fathers (hazard ratio = 1.88, 95% confidence interval: 0.93, 3.82), after adjustment for maternal age, reproductive history, and maternal...

  1. The effect of aging on atherosclerotic plaque inflammation and molecular calcification: A PET CT imaging study

    DEFF Research Database (Denmark)

    Blomberg, Björn; Thomassen, Anders; Simonsen, Jane Angel

    Aim: Aging is an important independent risk factor for the inception and maturation of atherosclerotic plaques. This study aimed to investigate the effect of aging on atherosclerotic plaque inflammation and molecular calcification. Methods: Thirteen healthy volunteers without traditional......SUV) [Mean SUVAORTA - Mean SUVBLOOD POOL]. Furthermore, the average maximum 18F-NaF cSUV was determined in the coronary arteries. Calculating regression and correlation coefficients summarized the data. Results: A quadratic relationship was observed between aging and aortic 18F-FDG avidity. A second order...... polynomial regression established that aging is a strong predictor of the degree of aortic plaque inflammation (R2 = 0.71, F statistic = 11.98, P = 0.002). A linear relationship was observed between aging and molecular calcification. Linear regression established that aging is a predictor of both the degree...

  2. Aging of nuclear station diesel generators: Evaluation of operating and expert experience: Phase 1, Study

    International Nuclear Information System (INIS)

    Hoopingarner, K.R.; Vause, J.W.; Dingee, D.A.; Nesbitt, J.F.

    1987-08-01

    Pacific Northwest Laboratory evaluated operational and expert experience pertaining to the aging degradation of diesel generators in nuclear service. The research, sponsored by the US Nuclear Regulatory Commission (NRC), identified and characterized the contribution of aging to emergency diesel generator failures. This report, Volume I, reviews diesel-generator experience to identify the systems and components most subject to aging degradation and isolates the major causes of failure that may affect future operational readiness. Evaluations show that as plants age, the percent of aging-related failures increases and failure modes change. A compilation is presented of recommended corrective actions for the failures identified. This study also includes a review of current, relevant industry programs, research, and standards. Volume II reports the results of an industry-wide workshop held on May 28 and 29, 1986 to discuss the technical issues associated with aging of nuclear service emergency diesel generators

  3. Age-related differences in emotion recognition ability: a cross-sectional study.

    Science.gov (United States)

    Mill, Aire; Allik, Jüri; Realo, Anu; Valk, Raivo

    2009-10-01

    Experimental studies indicate that recognition of emotions, particularly negative emotions, decreases with age. However, there is no consensus at which age the decrease in emotion recognition begins, how selective this is to negative emotions, and whether this applies to both facial and vocal expression. In the current cross-sectional study, 607 participants ranging in age from 18 to 84 years (mean age = 32.6 +/- 14.9 years) were asked to recognize emotions expressed either facially or vocally. In general, older participants were found to be less accurate at recognizing emotions, with the most distinctive age difference pertaining to a certain group of negative emotions. Both modalities revealed an age-related decline in the recognition of sadness and -- to a lesser degree -- anger, starting at about 30 years of age. Although age-related differences in the recognition of expression of emotion were not mediated by personality traits, 2 of the Big 5 traits, openness and conscientiousness, made an independent contribution to emotion-recognition performance. Implications of age-related differences in facial and vocal emotion expression and early onset of the selective decrease in emotion recognition are discussed in terms of previous findings and relevant theoretical models.

  4. Ageing study of protection automation components of Olkiluoto nuclear power plant

    International Nuclear Information System (INIS)

    Simola, K.; Haenninen, S.

    1993-07-01

    A study on ageing of reactor protection system of the Olkiluoto nuclear power plant is described. The objective of the study was to present an ageing analysis approach and apply in to the automation chains of reactor protection system of the Olkiluoto nuclear power plant. The study includes the measuring instrumentation, the protection logics, and the control electronics of some pumps and valves. The analysis is based on the information collected on the structure of the system, environmental conditions and maintenance practices of components, and operating experience. Based on this information, the possible ageing effects of equipment and their safety significance are evaluated. (orig.). (15 refs., 16 figs., 12 tabs.)

  5. Effects of aging on sleep structure throughout adulthood: a population-based study.

    Science.gov (United States)

    Moraes, Walter; Piovezan, Ronaldo; Poyares, Dalva; Bittencourt, Lia Rita; Santos-Silva, Rogerio; Tufik, Sergio

    2014-04-01

    Although many studies have shown the evolution of sleep parameters across the lifespan, not many have included a representative sample of the general population. The objective of this study was to describe age-related changes in sleep structure, sleep respiratory parameters and periodic limb movements of the adult population of São Paulo. We selected a representative sample of the city of São Paulo, Brazil that included both genders and an age range of 20-80 years. Pregnant and lactating women, people with physical or mental impairments that prevent self-care and people who work every night were not included. This sample included 1024 individuals who were submitted to polysomnography and structured interviews. We subdivided our sample into five-year age groups. One-way analysis of variance was used to compare age groups. Pearson product-moment was used to evaluate correlation between age and sleep parameters. Total sleep time, sleep efficiency, percentage of rapid eye movement (REM) sleep and slow wave sleep showed a significant age-related decrease (Pincrease (Pincreased and oxygen saturation decreased with age. The reduction in the percentage of REM sleep significantly correlated with age in women, whereas the reduction in the percentage of slow wave sleep correlated with age in men. The periodic limb movement (PLM) index increased with age in men and women. Sleep structure and duration underwent significant alterations throughout the aging process in the general population. There was an important correlation between age, sleep respiratory parameters and PLM index. In addition, men and women showed similar trends but with different effect sizes. Copyright © 2014 Elsevier B.V. All rights reserved.

  6. Alcohol consumption, smoking and development of visible age-related signs: a prospective cohort study.

    Science.gov (United States)

    Schou, Anne L; Mølbak, Marie-Louise; Schnor, Peter; Grønbæk, Morten; Tolstrup, Janne S

    2017-12-01

    Visible age-related signs indicate biological age, as individuals that appear old for their age are more likely to be at poor health, compared with people that appear their actual age. The aim of this study was to investigate whether alcohol and smoking are associated with four visible age-related signs (arcus corneae, xanthelasmata, earlobe crease and male pattern baldness). We used information from 11 613 individuals in the Copenhagen City Heart Study (1976-2003). Alcohol intake, smoking habits and other lifestyle factors were assessed prospectively and visible age-related signs were inspected during subsequent examinations. The risk of developing arcus corneae, earlobe crease and xanthelasmata increased stepwise with increased smoking as measured by pack-years. For alcohol consumption, a high intake was associated with the risk of developing arcus corneae and earlobe crease, but not xanthelasmata. High alcohol consumption and smoking predict development of visible age-related signs. This is the first prospective study to show that heavy alcohol use and smoking are associated with generally looking older than one's actual age. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  7. Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study.

    Science.gov (United States)

    Golding, Jean; Steer, Colin; Pembrey, Marcus

    2010-04-01

    A number of studies have assessed ages of parents of children with autistic spectrum disorders (ASD), and reported both maternal and paternal age effects. Here we assess relationships with grandparental ages. We compared the parental and grandparental ages of children in the population-based Avon Longitudinal Study of Parents and Children (ALSPAC), according to their scores in regard to 4 autistic trait measures and whether they had been given a diagnosis of ASD. Mean maternal and paternal ages of ASD cases were raised, but this appears to be secondary to a maternal grandmother age effect (P = 0.006): OR = 1.66[95%CI 1.16, 2.37] for each 10-year increase in the grandmother's age at the birth of the mother. Trait measures also revealed an association between the maternal grandmother's age and the major autistic trait-the Coherence Scale (regression coefficient b = 0.142, [95%CI = 0.057, 0.228]P = 0.001). After allowing for confounders the effect size increased to b = 0.217[95%CI 0.125, 0.308](Pautistic trait was unexpected, there is some biological plausibility, for the maternal side at least, given that the timing of female meiosis I permits direct effects on the grandchild's genome during the grandmother's pregnancy. An alternative explanation is the meiotic mismatch methylation (3 M) hypothesis, presented here for the first time. Nevertheless the findings should be treated as hypothesis generating pending corroborative results from other studies.

  8. The study of nursing students’ learning initiative in the course reform of aged caring

    Directory of Open Access Journals (Sweden)

    Sun Wenjing

    2017-01-01

    Full Text Available Purpose: Analyzing the influence of nursing students’ learning initiative in the course reform of aged caring. Discuss the way of the aged care reform. Method: To reform the course of aged care in our school level 2013 88 nursing undergraduate. The specific content: learning aged care theory, learning Japanese care technology basic knowledge, adding Japanese and Taiwan’s nursing concepts to the traditional aged care teaching, performing sitcoms about old people’s disease and nursing way , reporting the plan of aged care by PowerPoint, organizing student volunteers to visit the nursing home and so on. The specific content lasted four months. Adopting the learning initiative (ALS scale developed by Zang Yuli and others after course reform. Measure the students’ learning initiative before and after the teaching. Result: Nursing student’s self-study ability was in the middle and lower level before the course reform(59.26±7.38; After the course reform, nursing student gain higher score than before learning on the three aspects contain “Learning motivation”,“Learning goals” and “Solid study”. The difference has statistically significant.(P<0.05.Conclusion: Through the aged care course reform, nursing students strengthen the study enthusiasm and initiative; enhance nursing student’s self-study ability. It is conducive to improve the learning interest of aged care course for nursing students.

  9. Renal hemodynamic changes with aging: a preliminary study using CT perfusion in the healthy elderly.

    Science.gov (United States)

    Zhao, Hong; Gong, Jingshan; Wang, Yan; Zhang, Zuoquan; Qin, Peixin

    2010-01-01

    To investigate renal blood flow perfusion parameter changes associated with aging using multislice spiral computed tomography (CT). This prospective study was approved by the institute's ethics committee for clinical study and written informed consent was obtained from all subjects. Forty-two consecutive patients who underwent abdominal CT without obvious renal abnormality at plain scanning were enrolled in this study. The renal perfusion scan was carried out using 16-slice spiral CT. The Pearson correlation coefficient was used to examine the correlation between perfusion parameter changes with aging. In both the cortex and medulla, blood flow (BF) and blood volume (BV) were negatively correlated with age, while time-to-peak (TTP) value and mean transit time (MTT) showed a positive correlation with age. Changes in BF, TTP, and MTT were found to have a statistically significant correlation with age in both the cortex and medulla, while the correlation between BV and age showed no statistical significance. It is feasible to assess renal hemodynamics changes with aging in the elderly using the current clinically available CT perfusion imaging technology in vivo. It may be helpful in the management of aged patients to familiarize with the renal hemodynamics changes in clinical work-up. Copyright 2010 Elsevier Inc. All rights reserved.

  10. Age-Related Change in Visual Working Memory: A study of 55,753 Participants Aged 8 to 75

    Directory of Open Access Journals (Sweden)

    James R. Brockmole

    2013-01-01

    Full Text Available Visual working memory abilities of 55,753 individuals between the ages of 8 and 75 were assessed to provide the most fine-grain analysis of age-related change in visual working memory to date. Results showed that visual working memory changes throughout the lifespan, peaking at age 20. A sharp linear decline follows that is so severe that by age 55, adults possess poorer immediate visual memory than 8 and 9 year olds. These developmental changes were largely explained by changing visual working memory capacity coupled with small short-term visual feature binding difficulties among children and older adults.

  11. Negative perceptions of ageing predict the onset and persistence of depression and anxiety: Findings from a prospective analysis of the Irish Longitudinal Study on Ageing (TILDA).

    Science.gov (United States)

    Freeman, Aislinné Theresa; Santini, Ziggi Ivan; Tyrovolas, Stefanos; Rummel-Kluge, Christine; Haro, Josep Maria; Koyanagi, Ai

    2016-07-15

    Although there is a growing literature on the adverse health outcomes related with negative ageing perceptions, studies on their association with mental disorders such as depression and anxiety are scarce. Thus, the aim of the current study was to prospectively assess the association between negative ageing perceptions and incident/persistent depression and anxiety using nationally representative data from Ireland. Data from two consecutive waves of the Irish Longitudinal Study on Ageing (TILDA) were analysed. The analytical sample consisted of 6095 adults aged ≥50 years. Validated scales for negative ageing perceptions, depression, and anxiety were used. Multivariable logistic regression analyses were used to assess the association between negative ageing perceptions at baseline and the onset and persistence of depression and anxiety at two-year follow up. After adjusting for potential confounders, negative ageing perceptions at baseline predicted the new onset of depression and anxiety at follow-up. Among those with depression or anxiety at baseline, negative ageing perceptions also predicted the persistence of these conditions at follow-up. Baseline data on negative ageing perceptions were used for the analysis and it is possible that scores could have changed over time. Addressing negative perceptions towards ageing by developing interventions that activate positive ageing perceptions, and target societal attitudes by means of policy change, public campaigns, and community education programmes, may shift social perceptions and reduce the burden of depression and anxiety among the elderly. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  12. Magnetic ageing study of high and medium permeability nanocrystalline FeSiCuNbB alloys

    Energy Technology Data Exchange (ETDEWEB)

    Lekdim, Atef, E-mail: atef.lekdim@univ-lyon1.fr; Morel, Laurent; Raulet, Marie-Ange

    2017-04-15

    increasing the energy efficiency is one of the most important issues in modern power electronic systems. In aircraft applications, the energy efficiency must be associated with a maximum reduction of mass and volume, so a high components compactness. A consequence from this compactness is the increase of operating temperature. Thus, the magnetic materials used in these applications, have to work at high temperature. It raises the question of the thermal ageing problem. The reliability of these components operating at this condition becomes a real problem which deserves serious interest. Our work takes part in this context by studying the magnetic material thermal ageing. The nanocrystalline materials are getting more and more used in power electronic applications. Main advantages of nanocrystalline materials compared to ferrite are: high saturation flux density of almost 1.25 T and low dynamic losses for low and medium frequencies. The nanocrystalline Fe{sub 73.5}Cu{sub 1}Nb{sub 3}Si{sub 15.5}B{sub 7} alloys have been chosen in our aging study. This study is based on monitoring the magnetic characteristics for several continuous thermal ageing (100, 150, 200 and 240 °C). An important experimental work of magnetic characterization is being done following a specific monitoring protocol. Elsewhere, X-Ray Diffraction and magnetostriction measurements were carried out to support the study of the anisotropy energies evolution with ageing. This latter is discussed in this paper to explain and give hypothesis about the ageing phenomena. - Highlights: • The magnetic ageing of the nanocrystalline materials is related to their annealing. • The degradations with ageing are not related to a change of the grain size diameter. • The amount of anisotropies introduced with ageing depends just on ageing conditions.

  13. Development of a Healthy Aging Score in the Population-Based Rotterdam Study: Evaluating Age and Sex Differences.

    Science.gov (United States)

    Jaspers, Loes; Schoufour, Josje D; Erler, Nicole S; Darweesh, Sirwan K L; Portegies, Marileen L P; Sedaghat, Sanaz; Lahousse, Lies; Brusselle, Guy G; Stricker, Bruno H; Tiemeier, Henning; Ikram, M Arfan; Laven, Joop S E; Franco, Oscar H; Kavousi, Maryam

    2017-03-01

    To develop a healthy aging score (HAS), to assess age and sex differences in HAS, and to evaluate the association of the HAS with survival. Prospective population-based cohort. Inhabitants of Ommoord, Rotterdam, The Netherlands. A total of 1405 men and 2122 women, mean (standard deviation) age 75.9 (6.4) years. We included 7 domains in the total score of HAS: chronic diseases, mental health, cognitive function, physical function, pain, social support, and quality of life; each scored 0, 1, or 2 in each domain. A total score (range 0-14) was constructed and was assessed continuously and in tertiles (13-14: healthy aging, 11-12: intermediate aging, 0-10: poor aging). Sex-specific change in the mean HAS was computed for the age categories of 65-69, 70-74, 75-79, 80-84, and ≥85 years. The association between HAS and mortality was assessed with Cox proportional hazards models. Mean follow-up was 8.6 (3.4) years. Men had poorer scores in the chronic disease domain than women. However, women had poorer mental health, worse physical function, more pain, and lower quality of life compared with men. The prevalence of healthy aging was higher in men (n = 396, 28.2%), than in women (n = 526, 24.8%). The mean (standard deviation) HAS was 11.1 (2.2) in men and 10.7 (2.3) in women. Mean HAS was higher in men than in women for all age categories. The β for change in mean HAS across the 5 increasing age categories was -0.55 (-0.65 to -0.45) in men and -0.65 (-0.73 to -0.57) in women. The age-adjusted hazard ratio per unit increase in HAS with mortality was 0.86 (0.83-0.89) in men, and 0.89 (0.87-0.91) in women. Levels of HAS were lower in women compared with men, in all age categories. The HAS declined with increasing age for both sexes, albeit slightly steeper in women. The HAS was strongly associated with mortality in both sexes. A better understanding of population healthy aging and sex differences in this regard could aid to implement strategies for sustainable

  14. Aging Well: Observations From the Women’s Health Initiative Study

    Science.gov (United States)

    Rillamas-Sun, Eileen; Cochrane, Barbara B.; La Croix, Andrea Z.; Seeman, Teresa E.; Tindle, Hilary A.; Zaslavsky, Oleg; Bird, Chloe E.; Johnson, Karen C.; Manson, JoAnn E.; Ockene, Judith K.; Seguin, Rebecca A.; Wallace, Robert B.

    2016-01-01

    Abstract Background. As the proportion of the population aged 80 and over accelerates, so does the value of understanding the processes of aging well. The purposes of this article are to: (a) review contemporary theoretical and conceptual perspectives on aging well, (b) describe indicators of aging well that reflect key concepts and perspectives as assessed in the Women’s Health Initiative (WHI) and (c) characterize the status of aging among women aged 80 and older using data obtained from WHI participants at the WHI Extension 2 follow-up. Methods. Data from the Lifestyle Questionnaire, which was administered from 2011 to 2012 during the WHI Follow-up Study (Extension 2), were analyzed to provide a profile of the WHI cohort with respect to aging well. Results. Data revealed substantial diversity in the cohort with respect to the various measures of aging well. Although many reported physical functioning levels consistent with disability, most rated their health as good or better. Most reported moderately high levels of resilience, self-control, and self-mastery but lower levels of environmental mastery. Finally, the cohort reported high levels of optimal aging as reflected by their high levels of emotional well-being and moderately high levels of life satisfaction and social support, but more modest levels of personal growth and purpose in life. Conclusions. The wide range of some dimensions of aging well suggest that further examination of predictors of positive coping and resilience in the face of aging-related disability could identify opportunities to support and facilitate aging well among U.S. women. PMID:26858322

  15. Age-related differences in dual task performance: A cross-sectional study on women.

    Science.gov (United States)

    Brustio, Paolo R; Magistro, Daniele; Rabaglietti, Emanuela; Liubicich, Monica E

    2017-02-01

    Simultaneous performances of motor and attention-demanding tasks are common in activities of everyday life. The present cross-sectional study examined the changes and age-related differences on mobility performance with an additional cognitive or motor task, and evaluated the relative dual-task cost (DTC) on the motor performance in young, middle-aged and older women. A total of 30 young (mean age 25.12 ± 3.00 years), 30 middle-aged (mean age 47.82 ± 5.06 years) and 30 older women (mean age 72.74 ± 5.95 years) were recruited. Participants carried out: (i) single task: Timed Up & Go Test; (ii) cognitive dual-task: Timed Up & Go Test while counting backwards by three; (iii) manual dual-task: Timed Up & Go Test while carrying a glass of water. A repeated measures anova with between-factor as age groups and within-factor as tasks was carried out to assess the effect of aging on the performance of mobility tasks. DTC was calculated as ([performance in single-task - performance in dual-task] / performance in single task) × 100%. One-way ancova were carried out to compare the DTC among the three age groups. A significant interaction between age groups and task (F 4,172  = 6.716, P performance under dual-task condition compared with young and middle-aged groups. Furthermore, DTC differences in cognitive task were observed in older women compared with younger and middle-aged women (F 2,86  = 7.649, P task. Dual-task conditions might affect mobility performance differently across the lifespan, and could be particularly challenging in older women. Geriatr Gerontol Int 2017; 17: 315-321. © 2015 Japan Geriatrics Society.

  16. Sensory processing difficulties in school-age children born very preterm : An exploratory study

    NARCIS (Netherlands)

    Bröring, Tinka; Königs, Marsh; Oostrom, Kim J.; Lafeber, Harrie N.; Brugman, Anniek; Oosterlaan, Jaap

    Background Very preterm birth has a detrimental impact on the developing brain, including widespread white matter brain abnormalities that threaten efficient sensory processing. Yet, sensory processing difficulties in very preterm children are scarcely studied, especially at school age. Aims To

  17. Age-related changes in functional connectivity of cerebellar PlV: a FDG PET study

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Sang Soo; Yoon, Eun Jin; Bang, Seong Ae; Park, Hyun Soo; Kim, Yu Kyeong; Kim, Sang Eun [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2007-07-01

    The cerebellum is known to have strong connection with cerebral cortex, and it shows the greatest mean shrinkage with aging. Changes in functional connectivity between cerebellum and cortical and subcortical cerebral areas possibly occur in normal aging. In this study, we tested changes of interregional connection between cerebellar posterior inferior vermis (PIV) and cerebrum in healthy subjects divided in three classes of age group (young: 20-30, middle age: 40-50, elderly: over 60 years) using FDG PET. 211 healthy subjects (age, 20-82 y; 134 female) were studied with resting-state brain glucose utilization measured by FDG-PET, cerebellar PIV activity after count-normalization to the whole gray matter mean count was extracted. Using PIV count as a 'seed', the maps of cross-correlation coefficients were computed by measuring the correlation between 'seed' and all the other brain voxels (P < 0.001 uncorrected, k = 100). Across all age groups, positive correlations of metabolic activity in the cerebellar PIV showed in cerebellum itself and bilateral thalamus. An extended positive correlation in cuneus which is served for visual information processing was observed in middle aged and elderly group differently from the young group. Also, in elderly group, this correlation was observed in the frontal areas such as right orbital and precentral gyri. Negative correlation implicating mutual inhibition between the areas was also founded in prefrontal and cingulate cortices and temporoparietal association areas. Comparing with the young group, in theses areas, enlarged negative correlations was founded with aging. We identified age related changes in cerebrocerebellar communication loop which reflect changes in local neuroplasticity in the normal aging brain. Present result may have implication for understanding the functional decline of cerebellum related cognitive ability as well as the deficit of motor coordination in normal aging and its compensation

  18. Delivery outcomes for nulliparous women at the extremes of maternal age - a cohort study.

    LENUS (Irish Health Repository)

    Vaughan, DA

    2013-06-12

    OBJECTIVE: To examine the associations between extremes of maternal age (≤17 years or ≥40 years) and delivery outcomes. DESIGN: Retrospective cohort study. SETTING: Urban maternity hospital in Ireland. POPULATION: A total of 36 916 nulliparous women with singleton pregnancies who delivered between 2000 and 2011. METHODS: The study population was subdivided into five maternal age groups based on age at first booking visit: ≤17 years, 18-19 years, 20-34 years, 35-39 years and women aged ≥40 years. Logistic regression analyses were performed to examine the associations between extremes of maternal age and delivery outcomes, adjusting for potential confounding factors. MAIN OUTCOME MEASURES: Preterm birth, admission to the neonatal unit, congenital anomaly, caesarean section. RESULTS: Compared with maternal age 20-34 years, age ≤17 years was a risk factor for preterm birth (adjusted odds ratio [adjOR] 1.83, 95% confidence interval [95% CI] 1.33-2.52). Babies born to mothers ≥40 years were more likely to require admission to the neonatal unit (adjOR 1.35, 95% CI 1.06-1.72) and to have a congenital anomaly (adjOR 1.71, 95% CI 1.07-2.76). The overall caesarean section rate in nulliparous women was 23.9% with marked differences at the extremes of maternal age; 10.7% at age ≤17 years (adjOR 0.46, 95% CI 0.34-0.62) and 54.4% at age ≥40 years (adjOR 3.24, 95% CI 2.67-3.94). CONCLUSIONS: Extremes of maternal age need to be recognised as risk factors for adverse delivery outcomes. Low caesarean section rates in younger women suggest that a reduction in overall caesarean section rates may be possible.

  19. Age-related changes in functional connectivity of cerebellar PlV: a FDG PET study

    International Nuclear Information System (INIS)

    Cho, Sang Soo; Yoon, Eun Jin; Bang, Seong Ae; Park, Hyun Soo; Kim, Yu Kyeong; Kim, Sang Eun

    2007-01-01

    The cerebellum is known to have strong connection with cerebral cortex, and it shows the greatest mean shrinkage with aging. Changes in functional connectivity between cerebellum and cortical and subcortical cerebral areas possibly occur in normal aging. In this study, we tested changes of interregional connection between cerebellar posterior inferior vermis (PIV) and cerebrum in healthy subjects divided in three classes of age group (young: 20-30, middle age: 40-50, elderly: over 60 years) using FDG PET. 211 healthy subjects (age, 20-82 y; 134 female) were studied with resting-state brain glucose utilization measured by FDG-PET, cerebellar PIV activity after count-normalization to the whole gray matter mean count was extracted. Using PIV count as a 'seed', the maps of cross-correlation coefficients were computed by measuring the correlation between 'seed' and all the other brain voxels (P < 0.001 uncorrected, k = 100). Across all age groups, positive correlations of metabolic activity in the cerebellar PIV showed in cerebellum itself and bilateral thalamus. An extended positive correlation in cuneus which is served for visual information processing was observed in middle aged and elderly group differently from the young group. Also, in elderly group, this correlation was observed in the frontal areas such as right orbital and precentral gyri. Negative correlation implicating mutual inhibition between the areas was also founded in prefrontal and cingulate cortices and temporoparietal association areas. Comparing with the young group, in theses areas, enlarged negative correlations was founded with aging. We identified age related changes in cerebrocerebellar communication loop which reflect changes in local neuroplasticity in the normal aging brain. Present result may have implication for understanding the functional decline of cerebellum related cognitive ability as well as the deficit of motor coordination in normal aging and its compensation mechanism of brain

  20. Demonstration of statistical approaches to identify component's ageing by operational data analysis-A case study for the ageing PSA network

    International Nuclear Information System (INIS)

    Rodionov, Andrei; Atwood, Corwin L.; Kirchsteiger, Christian; Patrik, Milan

    2008-01-01

    The paper presents some results of a case study on 'Demonstration of statistical approaches to identify the component's ageing by operational data analysis', which was done in the frame of the EC JRC Ageing PSA Network. Several techniques: visual evaluation, nonparametric and parametric hypothesis tests, were proposed and applied in order to demonstrate the capacity, advantages and limitations of statistical approaches to identify the component's ageing by operational data analysis. Engineering considerations are out of the scope of the present study

  1. Comparison study on mechanical properties single step and three step artificial aging on duralium

    Science.gov (United States)

    Tsamroh, Dewi Izzatus; Puspitasari, Poppy; Andoko, Sasongko, M. Ilman N.; Yazirin, Cepi

    2017-09-01

    Duralium is kind of non-ferro alloy that used widely in industrial. That caused its properties such as mild, high ductility, and resistance from corrosion. This study aimed to know mechanical properties of duralium on single step and three step articial aging process. Mechanical properties that discussed in this study focused on toughness value, tensile strength, and microstructure of duralium. Toughness value of single step artificial aging was 0.082 joule/mm2, and toughness value of three step artificial aging was 0,0721 joule/mm2. Duralium tensile strength of single step artificial aging was 32.36 kgf/mm^2, and duralium tensile strength of three step artificial aging was 32,70 kgf/mm^2. Based on microstructure photo of duralium of single step artificial aging showed that precipitate (θ) was not spreading evenly indicated by black spot which increasing the toughness of material. While microstructure photo of duralium that treated by three step artificial aging showed that it had more precipitate (θ) spread evenly compared with duralium that treated by single step artificial aging.

  2. Sexual Quality of Life and Aging: A Prospective Study of a Nationally Representative Sample.

    Science.gov (United States)

    Forbes, Miriam K; Eaton, Nicholas R; Krueger, Robert F

    2017-02-01

    Unlike other life domains, sexual quality of life (SQoL) has a negative relationship with age. This study disentangled the effect of age in this relationship from confounding sociocultural influences (e.g., the period of time in which data were collected, and cohort differences) and aimed to understand the roles of other sexual domains (i.e., frequency, perceived control, thought and effort invested in sex, and number of sexual partners). We analyzed data from the longitudinal Midlife in the United States study (n = 6,278; age range 20-93), which were collected between 1995 and 2013. Repeated measures linear mixed-effects models showed that age was the most robust time-related predictor of declining SQoL. However, after the sexual domains were included in the model, age had a positive relationship with SQoL and older adults' SQoL was differentially influenced by the quality-not quantity-of sex. When partnership characteristics were included in the model, age was no longer related to SQoL. These findings suggest that aging may be associated with the acquisition of skills and strategies that can buffer age-related declines in SQoL, particularly in the context of a positive relationship. We summarize these findings as sexual wisdom.

  3. Association of maternal age with child health: A Japanese longitudinal study.

    Directory of Open Access Journals (Sweden)

    Tsuguhiko Kato

    Full Text Available Average maternal age at birth has been rising steadily in Western and some Asian countries. Older maternal age has been associated with adverse pregnancy and birth outcomes; however, studies on the relationship between maternal age and young children's health remain scarce. Therefore, we sought to investigate the association of maternal age with child health outcomes in the Japanese population. We analyzed data from two birth cohorts of the nationwide Japanese Longitudinal Survey of Babies in 21st Century (n2001 = 47,715 and n2010 = 38,554. We estimated risks of unintentional injuries and hospital admissions at 18 and 66 months according to maternal age, controlling for the following potential confounders: parental education; maternal parity, smoking status, and employment status; household income; paternal age, and sex of the child. We also included the following as potential mediators: preterm births and birthweight. We observed a decreasing trend in the risks of children's unintentional injuries and hospital admissions at 18 months according to maternal age in both cohorts. In the 2001 cohort, compared to mothers 40.0 years, respectively, controlling for confounders. Our findings were in line with previous findings from population-based studies conducted in the United Kingdom and Canada suggesting that older maternal age may be beneficial for early child health.

  4. Is 27 really a dangerous age for famous musicians? Retrospective cohort study.

    Science.gov (United States)

    Wolkewitz, Martin; Allignol, Arthur; Graves, Nicholas; Barnett, Adrian G

    2011-12-20

    To test the "27 club" hypothesis that famous musicians are at an increased risk of death at age 27. Design Cohort study using survival analysis with age as a time dependent exposure. Comparison was primarily made within musicians, and secondarily relative to the general UK population. The popular music scene from a UK perspective. Musicians (solo artists and band members) who had a number one album in the UK between 1956 and 2007 (n = 1046 musicians, with 71 deaths, 7%). Risk of death by age of musician, accounting for time dependent study entry and the number of musicians at risk. Risk was estimated using a flexible spline which would allow a bump at age 27 to appear. We identified three deaths at age 27 amongst 522 musicians at risk, giving a rate of 0.57 deaths per 100 musician years. Similar death rates were observed at ages 25 (rate = 0.56) and 32 (0.54). There was no peak in risk around age 27, but the risk of death for famous musicians throughout their 20s and 30s was two to three times higher than the general UK population. The 27 club is unlikely to be a real phenomenon. Fame may increase the risk of death among musicians, but this risk is not limited to age 27.

  5. Genotype by sex and genotype by age interactions with sedentary behavior: the Portuguese Healthy Family Study.

    Directory of Open Access Journals (Sweden)

    Daniel M V Santos

    Full Text Available Sedentary behavior (SB expression and its underlying causal factors have been progressively studied, as it is a major determinant of decreased health quality. In the present study we applied Genotype x Age (GxAge and Genotype x Sex (GxSex interaction methods to determine if the phenotypic expression of different SB traits is influenced by an interaction between genetic architecture and both age and sex. A total of 1345 subjects, comprising 249 fathers, 327 mothers, 334 sons and 325 daughters, from 339 families of The Portuguese Healthy Family Study were included in the analysis. SB traits were assessed by means of a 3-d physical activity recall, the Baecke and IPAQ questionnaires. GxAge and GxSex interactions were analyzed using SOLAR 4.0 software. Sedentary behaviour heritability estimates were not always statistically significant (p>0.05 and ranged from 3% to 27%. The GxSex and GxAge interaction models were significantly better than the single polygenic models for TV (min/day, EEsed (kcal/day, personal computer (PC usage and physical activty (PA tertiles. The GxAge model is also significantly better than the polygenic model for Sed (min/day. For EEsed, PA tertiles, PC and Sed, the GxAge interaction was significant because the genetic correlation between SB environments was significantly different from 1. Further, PC and Sed variance heterogeneity among distinct ages were observed. The GxSex interaction was significant for EEsed due to genetic variance heterogeneity between genders and for PC due to a genetic correlation less than 1 across both sexes. Our results suggest that SB expression may be influenced by the interactions between genotype with both sex and age. Further, different sedentary behaviors seem to have distinct genetic architectures and are differentially affected by age and sex.

  6. [Successful aging and indicators of frailty in the elderly. Octabaix Study].

    Science.gov (United States)

    Ferrer, Assumpta; Formiga, Francesc; Sanz, Héctor; Monserrate, Elena; Verges, Dolors

    2014-11-01

    Successful aging as a process of adaptation to the optimal state is little known in older people. To describe successful aging and to analyze the factors associated with frailty in people aged 86 years. A cross-sectional study of a clinical trial at the second year of follow-up (Octabaix Study). Seven Primary Care Centers. Non-institutionalized subjects born in 1924. Data on sociodemographic, comorbidity and geriatric assessment scales were collected. Frailty was defined by the presence of 3 or more of the following criteria: muscle weakness, slow walking, weight loss, exhaustion, low physical activity. Successful aging was defined as: Barthel index >90/100 and Lobo test ≥ 24/35. Multiple regression analysis was performed. A total of 273 patients were evaluated, 39.2% men. The prevalence of successful aging was 47.2% (129). In the unsuccessful aging, the frailty prevalence was 34.7% (50). The frailty factors associated with unsuccessful aging were low activity (OR: 7.56; 95%CI: 3.8 -14.9), weakness (OR: 6.08; 95%CI: 2.5-14.7), slowness (OR: 5.1; 95%CI: 2.8-9.5), and exhaustion (OR: 3.6; 95%CI: 1.6-8.3). The prevalence of successful aging is high in 86-year-old community-dwelling subjects. The low physical activity multiplied by seven, and muscle weakness by 6, were the factors most associated with unsuccessful aging. Therefore, incorporating screening designed to detect these two factors could improve future interventions towards more optimal aging in the community, if these results are confirmed in future studies. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

  7. Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study.

    Directory of Open Access Journals (Sweden)

    Jean Golding

    2010-04-01

    Full Text Available A number of studies have assessed ages of parents of children with autistic spectrum disorders (ASD, and reported both maternal and paternal age effects. Here we assess relationships with grandparental ages.We compared the parental and grandparental ages of children in the population-based Avon Longitudinal Study of Parents and Children (ALSPAC, according to their scores in regard to 4 autistic trait measures and whether they had been given a diagnosis of ASD. Mean maternal and paternal ages of ASD cases were raised, but this appears to be secondary to a maternal grandmother age effect (P = 0.006: OR = 1.66[95%CI 1.16, 2.37] for each 10-year increase in the grandmother's age at the birth of the mother. Trait measures also revealed an association between the maternal grandmother's age and the major autistic trait-the Coherence Scale (regression coefficient b = 0.142, [95%CI = 0.057, 0.228]P = 0.001. After allowing for confounders the effect size increased to b = 0.217[95%CI 0.125, 0.308](P<0.001 for each 10 year increase in age.Although the relationship between maternal grandmother's age and ASD and a major autistic trait was unexpected, there is some biological plausibility, for the maternal side at least, given that the timing of female meiosis I permits direct effects on the grandchild's genome during the grandmother's pregnancy. An alternative explanation is the meiotic mismatch methylation (3 M hypothesis, presented here for the first time. Nevertheless the findings should be treated as hypothesis generating pending corroborative results from other studies.

  8. Effect of maternal age on the risk of preterm birth: A large cohort study.

    Science.gov (United States)

    Fuchs, Florent; Monet, Barbara; Ducruet, Thierry; Chaillet, Nils; Audibert, Francois

    2018-01-01

    Maternal age at pregnancy is increasing worldwide as well as preterm birth. However, the association between prematurity and advanced maternal age remains controversial. To evaluate the impact of maternal age on the occurrence of preterm birth after controlling for multiple known confounders in a large birth cohort. Retrospective cohort study using data from the QUARISMA study, a large Canadian randomized controlled trial, which collected data from 184,000 births in 32 hospitals. Inclusion criteria were maternal age over 20 years. Exclusion criteria were multiple pregnancy, fetal malformation and intra-uterine fetal death. Five maternal age categories were defined and compared for maternal characteristics, gestational and obstetric complications, and risk factors for prematurity. Risk factors for preterm birth births were included in the study. Chronic hypertension, assisted reproduction techniques, pre-gestational diabetes, invasive procedure in pregnancy, gestational diabetes and placenta praevia were linearly associated with increasing maternal age whereas hypertensive disorders of pregnancy followed a "U" shaped distribution according to maternal age. Crude rates of preterm birth before 37 weeks followed a "U" shaped curve with a nadir at 5.7% for the group of 30-34 years. In multivariate analysis, the adjusted odds ratio (aOR) of prematurity stratified by age group followed a "U" shaped distribution with an aOR of 1.08 (95%CI; 1.01-1.15) for 20-24 years, and 1.20 (95% CI; 1.06-1.36) for 40 years and older. Confounders found to have the greatest impact were placenta praevia, hypertensive complications, and maternal medical history. Even after adjustment for confounders, advanced maternal age (40 years and over) was associated with preterm birth. A maternal age of 30-34 years was associated with the lowest risk of prematurity.

  9. Aging studies of batteries and transformers in class IE power systems

    International Nuclear Information System (INIS)

    Edson, J.L.; Roberts, E.W.

    1992-01-01

    A Phase I aging study of batteries used in 1E Power Systems of nuclear power plants concluded that significant aging effects for aged batteries are growth of positive plants, loosening of active material in plates that have grown, loss of active material caused by gassing and corrosion, and embrittlement of the lead grids and straps. These effects contribute to decreased electrical capacity and decreased seismic ruggedness which, during a seismic event, can lead to decreased electrical performance or complete failure. Subsequently a Phase II test program was conducted to determine if seismic ruggedness of aged batteries can be inadequate even if the electrical capacity is satisfactory, as determined by tests recommended by IEEE Std 450-1987, open-quote IEEE Recommended Practice for Maintenance, Testing, and Replacement of Large Storage Batteries for Generating Stations and Substations.close quotes In addition, a Phase I aging study of transformers in 1E Power Systems was performed to identify stressors and failure mechanisms, investigate whether transformers are showing the effects of aging as they grow older, and to determine if current surveillance methods are effective in mitigating aging effects. This paper presents the results of these studies

  10. Epigenome-Wide Association Study of Cognitive Functioning in Middle-Aged Monozygotic Twins

    DEFF Research Database (Denmark)

    Starnawska, Anna; Tan, Qihua; McGue, Matt

    2017-01-01

    As the world's population ages, the age-related cognitive decline presents a great challenge to world's healthcare systems. One of the molecular mechanisms implicated in cognitive ageing is DNA methylation, an epigenetic modification known to be a key player in memory formation, maintenance......, and synaptic plasticity. Using the twin design we performed an epigenome-wide association study (EWAS) in a population of 486 middle-aged monozygotic twins (mean age at follow-up 65.9, SD = 6.1) and correlated their blood DNA methylation to their level (cross-sectional analysis) and change in cognitive...... abilities over 10 years (longitudinal analysis). We identified several CpG sites where cross-sectional cognitive functioning was associated with DNA methylation levels. The top identified loci were located in ZBTB46 (p = 5.84 × 10-7), and TAF12 (p = 4.91 × 10-7). KEGG's enrichment analyses of the most...

  11. The Study of enclaves and relative age of plutonic bodies in the Alvand Plutonic complex

    International Nuclear Information System (INIS)

    Sepahi Gerow, A. A.; Moien-Vaziri, H.

    2000-01-01

    The study of enclaves and field observations indicate that: The Alvand plutonic complex comprise several plutonic phases with sharp contact and different ages. The older plutonic rocks are composed of gabbro, diorite and tonalites. The porphyroid granites were formed at least in two phases and they are younger than gabbros, diorites and tonalites. The hololeucocratic granitoids were also formed in two phases and they are the youngest plutonic phase in the Alvand plutonic complex. The granitic rocks are magmatic and they are not metasomatic in origin. The porphyroid granites (monzogranites and granodiorites) are S-type (Anatexites). According to radiometric ages and relative ages we believe that mafic plutonism have occurred during pre-middle Cretaceous to Paleocene ages and felsic plutonism have occurred during middle Cretaceouc to Paleocene ages

  12. Crystal Structure Studies of Human Dental Apatite as a Function of Age

    Directory of Open Access Journals (Sweden)

    Th. Leventouri

    2009-01-01

    Full Text Available Studies of the average crystal structure properties of human dental apatite as a function of age in the range of 5–87 years are reported. The crystallinity of the dental hydroxyapatite decreases with the age. The a-lattice constant that is associated with the carbonate content in carbonate apatite decreases with age in a systematic way, whereas the c-lattice constant does not change significantly. Thermogravimetric measurements demonstrate an increase of the carbonate content with the age. FTIR spectroscopy reveals both B and A-type carbonate substitutions with the B-type greater than the A-type substitution by a factor up to ~5. An increase of the carbonate content as a function of age can be deduced from the ratio of the 2CO3 to the 1PO4 IR modes.

  13. Validation of a clinical leadership qualities framework for managers in aged care: a Delphi study.

    Science.gov (United States)

    Jeon, Yun-Hee; Conway, Jane; Chenoweth, Lynn; Weise, Janelle; Thomas, Tamsin Ht; Williams, Anna

    2015-04-01

    To establish validity of a clinical leadership framework for aged care middle managers (The Aged care Clinical Leadership Qualities Framework). Middle managers in aged care have responsibility not only for organisational governance also and operational management but also quality service delivery. There is a need to better define clinical leadership abilities in aged care middle managers, in order to optimise their positional authority to lead others to achieve quality outcomes. A Delphi method. Sixty-nine experts in aged care were recruited, representing rural, remote and metropolitan community and residential aged care settings. Panellists were asked to rate the proposed framework in terms of the relevance and importance of each leadership quality using four-point Likert scales, and to provide comments. Three rounds of consultation were conducted. The number and corresponding percentage of the relevance and importance rating for each quality was calculated for each consultation round, as well as mean scores. Consensus was determined to be reached when a percentage score reached 70% or greater. Twenty-three panellists completed all three rounds of consultation. Following the three rounds of consultation, the acceptability and face validity of the framework was confirmed. The study confirmed the framework as useful in identifying leadership requirements for middle managers in Australian aged care settings. The framework is the first validated framework of clinical leadership attributes for middle managers in aged care and offers an initial step forward in clarifying the aged care middle manager role. The framework provides clarity in the breadth of role expectations for the middle managers and can be used to inform an aged care specific leadership program development, individuals' and organisations' performance and development processes; and policy and guidelines about the types of activities required of middle managers in aged care. © 2014 John Wiley & Sons Ltd.

  14. Aging system interaction studies: In-depth engineering studies of selected systems

    International Nuclear Information System (INIS)

    Jacobs, P.T.

    1986-01-01

    A research program sponsored by the US Nuclear Regulatory Commission to investigate the aging impact on nuclear plant safety is described. The program progress to date is summarized and plans for FY-1987 and beyond are discussed

  15. Aging-Resistant Functionalized LDH⁻SAS/Nitrile-Butadiene Rubber Composites: Preparation and Study of Aging Kinetics/Anti-Aging Mechanism.

    Science.gov (United States)

    Li, Tianxiang; Shi, Zhengren; He, Xianru; Jiang, Ping; Lu, Xiaobin; Zhang, Rui; Wang, Xin

    2018-05-18

    With the aim of improving the anti-aging properties of nitrile-butadiene rubber (NBR), a functional organic filler, namely LDH⁻SAS, prepared by intercalating 4-amino-benzenesulfonic acid monosodium salt (SAS) into layered double hydroxides (LDHs) through anion exchange, was added to nitrile-butadiene rubber (NBR), giving the NBR/LDH⁻SAS composites. Successful preparation of LDH⁻SAS was confirmed by XRD, TGA and FTIR. LDH⁻SAS was well dispersed in the NBR matrix, owing to its strong interaction with the nitrile group of NBR. The obtained NBR/LDH⁻SAS composites exhibited excellent thermo-oxidative aging resistance as shown by TGA-DSC. Further investigation by ATR-FTIR indicated that SAS can capture the radical groups, even during the aging process, which largely accounts for the improved aging resistance.

  16. Aging-Resistant Functionalized LDH–SAS/Nitrile-Butadiene Rubber Composites: Preparation and Study of Aging Kinetics/Anti-Aging Mechanism

    Science.gov (United States)

    Li, Tianxiang; Shi, Zhengren; He, Xianru; Jiang, Ping; Lu, Xiaobin; Zhang, Rui

    2018-01-01

    With the aim of improving the anti-aging properties of nitrile-butadiene rubber (NBR), a functional organic filler, namely LDH–SAS, prepared by intercalating 4-amino-benzenesulfonic acid monosodium salt (SAS) into layered double hydroxides (LDHs) through anion exchange, was added to nitrile-butadiene rubber (NBR), giving the NBR/LDH–SAS composites. Successful preparation of LDH–SAS was confirmed by XRD, TGA and FTIR. LDH–SAS was well dispersed in the NBR matrix, owing to its strong interaction with the nitrile group of NBR. The obtained NBR/LDH–SAS composites exhibited excellent thermo-oxidative aging resistance as shown by TGA-DSC. Further investigation by ATR-FTIR indicated that SAS can capture the radical groups, even during the aging process, which largely accounts for the improved aging resistance. PMID:29783656

  17. Maternal age during pregnancy is associated with third trimester blood pressure level: the generation R study.

    Science.gov (United States)

    Gaillard, Romy; Bakker, Rachel; Steegers, Eric A P; Hofman, Albert; Jaddoe, Vincent W V

    2011-09-01

    We hypothesized that hemodynamic adaptations related to pregnancy and ageing might be associated with differences in blood pressure levels during pregnancy between younger and older women. This might partly explain the increased risk of gestational hypertensive disorders with advanced maternal age. We examined the associations of maternal age with systolic and diastolic blood pressure in each trimester of pregnancy and the risks of gestational hypertensive disorders. The study was conducted among 8,623 women participating in a population-based prospective cohort study from early pregnancy onwards. Age was assessed at enrolment. Blood pressure was measured in each trimester. Information about gestational hypertensive disorders was available from medical records. In second and third trimester, older maternal age was associated with lower systolic blood pressure (-0.9 mm Hg (95% confidence interval: -1.4, -0.3) and -0.6 mm Hg (95% confidence interval: -1.1, -0.02) per additional 10 maternal years, respectively). Older maternal age was associated with higher third trimester diastolic blood pressure (0.5 mm Hg (95% confidence interval: 0.04, 0.9) per additional 10 maternal years). Maternal age was associated with pregnancy-induced hypertension among overweight and obese women. Older maternal age is associated with lower second and third trimester systolic blood pressure, but higher third trimester diastolic blood pressure. These blood pressure differences seem to be small and within the physiological range. Maternal age is not consistently associated with the risks of gestational hypertensive disorders. Maternal body mass index might influence the association between maternal age and the risk of pregnancy-induced hypertension.

  18. Posterior Cranial Fossa Crowdedness Is Related to Age and Sex: an Magnetic Resonance Volumetric Study

    International Nuclear Information System (INIS)

    Lirng, J.F.; Fuh, J.L.; Chen, Y.Y.; Wang, S.J.

    2005-01-01

    Purpose: To measure 3-dimensional (3D) posterior cranial fossa (PCF) crowdedness and to evaluate the effect of age, sex, and body height on PCF. Material and Methods: Fifty-two healthy volunteers (24 M and 28 F; mean age 55.4±17.2 years; range 24-82 years) were recruited. Using a semi-automated magnetic resonance technique, we calculated a PCF crowdedness index (CI) as the ratio of hindbrain (HB) volume to PCF volume x100% and correlated this index with age, sex, body height, and other crowdedness parameters. Results: The mean PCF CI was 93.7±2.7%. Women had a more crowded PCF than men (95.0±1.7% versus 92.1±2.7%; P <0.001). PCF CI declined with age for both men ( r = -0.61; P = 0.002) and women ( r = -0.68; P <0.001). The association with age - but not HB volume - was maintained after we controlled for sex and body height. On multiple regression, both age and sex accounted for 57.5% of the PCF CI variance. Conclusion: Our study shows that PCF CI is associated with age and sex, and can therefore be used as a surrogate to assess hindbrain atrophy in a cross-sectional sample. Moreover, sex- and age-specific normal ranges may be needed to evaluate the PCF CI in clinical practice

  19. Structural hippocampal network alterations during healthy aging: A multi-modal MRI study

    Directory of Open Access Journals (Sweden)

    Amandine ePelletier

    2013-12-01

    Full Text Available While hippocampal atrophy has been described during healthy aging, few studies have examined its relationship with the integrity of White Matter (WM connecting tracts of the limbic system. This investigation examined WM structural damage specifically related to hippocampal atrophy in healthy aging subjects (n=129, using morphological MRI to assess hippocampal volume and Diffusion Tensor Imaging (DTI to assess WM integrity. Subjects with Mild Cognitive Impairment (MCI or dementia were excluded from the analysis. In our sample, increasing age was significantly associated with reduced hippocampal volume and reduced Fractional Anisotropy (FA at the level of the fornix and the cingulum bundle. The findings also demonstrate that hippocampal atrophy was specifically associated with reduced FA of the fornix bundle, but it was not related to alteration of the cingulum bundle. Our results indicate that the relationship between hippocampal atrophy and fornix FA values is not due to an independent effect of age on both structures. A recursive regression procedure was applied to evaluate sequential relationships between the alterations of these two brain structures. When both hippocampal atrophy and fornix FA values were included in the same model to predict age, fornix FA values remained significant whereas hippocampal atrophy was no longer significantly associated with age. According to this latter finding, hippocampal atrophy in healthy aging could be mediated by a loss of fornix connections. Structural alterations of this part of the limbic system, which have been associated with neurodegeneration in Alzheimer’s disease, result at least in part from the aging process.

  20. Posterior Cranial Fossa Crowdedness Is Related to Age and Sex: an Magnetic Resonance Volumetric Study

    Energy Technology Data Exchange (ETDEWEB)

    Lirng, J.F.; Fuh, J.L.; Chen, Y.Y.; Wang, S.J. [Taipei Veterans General Hospital, Taiwan (China). Dept. of Radiology and Neurological Inst.

    2005-11-01

    Purpose: To measure 3-dimensional (3D) posterior cranial fossa (PCF) crowdedness and to evaluate the effect of age, sex, and body height on PCF. Material and Methods: Fifty-two healthy volunteers (24 M and 28 F; mean age 55.4{+-}17.2 years; range 24-82 years) were recruited. Using a semi-automated magnetic resonance technique, we calculated a PCF crowdedness index (CI) as the ratio of hindbrain (HB) volume to PCF volume x100% and correlated this index with age, sex, body height, and other crowdedness parameters. Results: The mean PCF CI was 93.7{+-}2.7%. Women had a more crowded PCF than men (95.0{+-}1.7% versus 92.1{+-}2.7%; P <0.001). PCF CI declined with age for both men ( r = -0.61; P = 0.002) and women ( r = -0.68; P <0.001). The association with age - but not HB volume - was maintained after we controlled for sex and body height. On multiple regression, both age and sex accounted for 57.5% of the PCF CI variance. Conclusion: Our study shows that PCF CI is associated with age and sex, and can therefore be used as a surrogate to assess hindbrain atrophy in a cross-sectional sample. Moreover, sex- and age-specific normal ranges may be needed to evaluate the PCF CI in clinical practice.

  1. Identity Formation in Adulthood: A Longitudinal Study from Age 27 to 50

    Science.gov (United States)

    Fadjukoff, Päivi; Pulkkinen, Lea; Kokko, Katja

    2016-01-01

    ABSTRACT Longitudinal patterns of identity formation were analyzed in a representative cohort group of Finnish men and women born in 1959 across ages 27, 36, 42, and 50. The data were drawn from the Jyväskylä Longitudinal Study of Personality. Identity status (diffused, moratorium, foreclosed, achieved) from all four ages was available for 172 participants (54% females). Marcia’s Identity Status Interview used in this research included five domains: religious beliefs, political identity, occupational career, intimate relationships, and lifestyle. The findings indicated great variability in identity status across domains at each age level, and the identity trajectories fluctuated from age 27 to 50. The developmental trend from age 27 to 50 was moderately progressive (toward achievement) for the five domains and for overall identity, with the exception of a slightly regressive trend in male religious identity. Remaining stable in the same status category across the four measurements was rare and emerged only for diffusion in the ideological domains. Women generally outnumbered men in identity achievement at earlier ages, but the gender differences diminished in most domains at age 50, except in religious identity. In women overall diffusion decreased over time, but in men it remained at about 20% at ages 42 and 50. PMID:27019650

  2. Reliability of third molar development for age estimation in Gujarati population: A comparative study.

    Science.gov (United States)

    Gandhi, Neha; Jain, Sandeep; Kumar, Manish; Rupakar, Pratik; Choyal, Kanaram; Prajapati, Seema

    2015-01-01

    Age assessment may be a crucial step in postmortem profiling leading to confirmative identification. In children, Demirjian's method based on eight developmental stages was developed to determine maturity scores as a function of age and polynomial functions to determine age as a function of score. Of this study was to evaluate the reliability of age estimation using Demirjian's eight teeth method following the French maturity scores and Indian-specific formula from developmental stages of third molar with the help of orthopantomograms using the Demirjian method. Dental panoramic tomograms from 30 subjects each of known chronological age and sex were collected and were evaluated according to Demirjian's criteria. Age calculations were performed using Demirjian's formula and Indian formula. Statistical analysis used was Chi-square test and ANOVA test and the P values obtained were statistically significant. There was an average underestimation of age with both Indian and Demirjian's formulas. The mean absolute error was lower using Indian formula hence it can be applied for age estimation in present Gujarati population. Also, females were ahead of achieving dental maturity than males thus completion of dental development is attained earlier in females. Greater accuracy can be obtained if population-specific formulas considering the ethnic and environmental variation are derived performing the regression analysis.

  3. The Gambian Bone and Muscle Ageing Study: Baseline Data from a Prospective Observational African Sub-Saharan Study

    Directory of Open Access Journals (Sweden)

    Ayse Zengin

    2017-08-01

    Full Text Available The Gambian Bone and Muscle Ageing Study is a prospective observational study investigating bone and muscle ageing in men and women from a poor, subsistence farming community of The Gambia, West Africa. Musculoskeletal diseases, including osteoporosis and sarcopenia, form a major part of the current global non-communicable disease burden. By 2050, the vast majority of the world’s ageing population will live in low- and middle-income countries with an estimated two-fold rise in osteoporotic fracture. The study design was to characterise change in bone and muscle outcomes and to identify possible preventative strategies for fracture and sarcopenia in the increasing ageing population. Men and women aged ≥40 years from the Kiang West region of The Gambia were recruited with stratified sampling by sex and age. Baseline measurements were completed in 488 participants in 2012 who were randomly assigned to follow-up between 1.5 and 2 years later. Follow-up measurements were performed on 465 participants approximately 1.7 years after baseline measurements. The data set comprises a wide range of measurements on bone, muscle strength, anthropometry, biochemistry, and dietary intake. Questionnaires were used to obtain information on health, lifestyle, musculoskeletal pain, and reproductive status. Baseline cross-sectional data show preliminary evidence for bone mineral density and muscle loss with age. Men had greater negative differences in total body lean mass with age than women following adjustments for body size. From peripheral quantitative computed tomography scans, greater negative associations between bone outcomes and age at the radius and tibia were shown in women than in men. Ultimately, the findings from The Gambian Bone and Muscle Ageing Study will contribute to the understanding of musculoskeletal health in a transitioning population and better characterise fracture and sarcopenia incidence in The Gambia with an aim to the

  4. CLINICAL STUDIES OF RENAL MORPHOLOGICAL CHANGES WITH AGING - DEMONSTRATING BY USING 99mTc-DMSA SCINTIGRAPHY -

    OpenAIRE

    細川, 進一; 川村, 寿一; 友吉, 唯夫; 吉田, 修

    1980-01-01

    We studied the change of renal shape due to development and aging by using 99mTc-DMSA renal scintigraphy. In pediatric age group, the angle between renal longitudinal axis and the lumbar vertebrae is small but becomes larger with aging. The renal size grows with aging in the adult age group, and becomes largest. In geriatric age group it decreases with aging. The stability of renal position is marked in the adult age group, but in the pediatric and geriatric age group it seemed unstable. Rena...

  5. Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.

    NARCIS (Netherlands)

    van Oostrom, Sandra H; Engelfriet, Peter M; Verschuren, W M Monique; Schipper, Maarten; Wouters, Inge M; Boezen, Marike; Smit, Henriëtte A; Kerstjens, Huib A M; Picavet, H Susan J

    2018-01-01

    The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS)

  6. Physical activity as a determinant of change in mobility performance : the Longitudinal Aging Study Amsterdam

    NARCIS (Netherlands)

    Visser, Marjolein; Pluijm, Saskia M F; Stel, Vianda S; Bosscher, Ruud J; Deeg, Dorly J H

    2002-01-01

    OBJECTIVES: This study examined the association of (change in) physical activity and decline in mobility performance in older men and women. DESIGN: A 3-year prospective study using data of the Longitudinal Aging Study. SETTING: Netherlands. PARTICIPANTS: Two thousand one hundred nine men and women

  7. Signs of Facial Aging in Men in a Diverse, Multinational Study: Timing and Preventive Behaviors.

    Science.gov (United States)

    Rossi, Anthony M; Eviatar, Joseph; Green, Jeremy B; Anolik, Robert; Eidelman, Michael; Keaney, Terrence C; Narurkar, Vic; Jones, Derek; Kolodziejczyk, Julia; Drinkwater, Adrienne; Gallagher, Conor J

    2017-11-01

    Men are a growing patient population in aesthetic medicine and are increasingly seeking minimally invasive cosmetic procedures. To examine differences in the timing of facial aging and in the prevalence of preventive facial aging behaviors in men by race/ethnicity. Men aged 18 to 75 years in the United States, Canada, United Kingdom, and Australia rated their features using photonumeric rating scales for 10 facial aging characteristics. Impact of race/ethnicity (Caucasian, black, Asian, Hispanic) on severity of each feature was assessed. Subjects also reported the frequency of dermatologic facial product use. The study included 819 men. Glabellar lines, crow's feet lines, and nasolabial folds showed the greatest change with age. Caucasian men reported more severe signs of aging and earlier onset, by 10 to 20 years, compared with Asian, Hispanic, and, particularly, black men. In all racial/ethnic groups, most men did not regularly engage in basic, antiaging preventive behaviors, such as use of sunscreen. Findings from this study conducted in a globally diverse sample may guide clinical discussions with men about the prevention and treatment of signs of facial aging, to help men of all races/ethnicities achieve their desired aesthetic outcomes.

  8. A Study of Correlation of Various Growth Indicators with Chronological Age.

    Science.gov (United States)

    Singh, Sarabjeet; Sandhu, Navreet; Puri, Taruna; Gulati, Ritika; Kashyap, Rita

    2015-01-01

    The aim of this study was to assess the relationship of chronological age with cervical vertebrae skeletal maturation, frontal sinus width and antegonial notch depth and a correlation, if any, among the three variables. The samples were derived from lateral cephalometric radiographs of 80 subjects (40 males, 40 females; age range: 10 to 19 years). Cervical vertebral development was evaluated by the method of Hassel and Farman, frontal sinus width was measured by the method described by Ertürk and antegonial notch depth as described by Singer et al. The Pearson's correlation coefficients were estimated to assess the relationship of chronological age with cervical vertebrae skeletal maturation, frontal sinus width and antegonial notch depth. The Pearson's correlation coefficient were 0.855 (p correlation was found between chronological age and cervical vertebrae skeletal maturation, and between chronological age and frontal sinus width. Nonsignificant correlation was found between chronological age and antegonial notch depth. How to cite this article: Singh S, Sandhu N, Puri T, Gulati R, Kashyap R. A Study of Correlation of Various Growth Indicators with Chronological Age. Int J Clin Pediatr Dent 2015;8(3): 190-195.

  9. State of the Art Study on Aging of Asphalt Mixtures and Use of Antioxidant Additives

    Directory of Open Access Journals (Sweden)

    Okan Sirin

    2018-01-01

    Full Text Available The detrimental effects of hardening in asphalt pavements were first recognized by pioneering pavement engineers in the 1900s and have been studied extensively during the last 70 years. This hardening process, referred to as asphalt aging, is generally defined as change in the rheological properties of asphalt binders/mixtures due to changes in chemical composition during construction and its service life period. Aging causes the asphalt material to stiffen and embrittle, which affects the durability and leads to a high potential for cracking. This paper presents the state of the art on asphalt and asphalt mixture aging and use of antioxidant additives to retard the aging. A picture of complex molecular structure of asphalt and its changes due to atmospheric condition and various protocols used to simulate aging in laboratory environment are also discussed. Emphasis is given on recent studies on simulation of aging of asphalt mixtures as there has been limited research on mixtures compared to the asphalt binder. Finally, this paper presents the application of antiaging techniques and its mechanism, use of various types of antioxidant additives to retard aging of asphalt and, hence, improve the performance of asphalt pavements.

  10. Why older workers work beyond the retirement age: a qualitative study.

    Science.gov (United States)

    Sewdas, Ranu; de Wind, Astrid; van der Zwaan, Lennart G L; van der Borg, Wieke E; Steenbeek, Romy; van der Beek, Allard J; Boot, Cécile R L

    2017-08-22

    The aims of the present study were to: 1) gain insight into reasons for working beyond the statutory retirement age from older workers' perspectives, and 2) explore how the domains of the research framework Study on Transitions in Employment, Ability and Motivation (STREAM) can be applied to working beyond retirement age. A qualitative research design included individual interviews (n = 15) and three focus groups (n = 18 participants) conducted with older workers aged 65 years and older continuing in a paid job or self-employment. Interview participants were recruited from an existing STREAM cohort study. Focus group participants were recruited from companies and employment agencies. The data were subjected to thematic analysis. The most important motives for working beyond retirement age were maintaining daily routines and financial benefit. Good health and flexible work arrangements were mentioned as important preconditions. The themes emerging from the categorization of the motives and preconditions corresponded to the domains of health, work characteristics, skills and knowledge, and social and financial factors from the STREAM research framework. However, our analysis revealed one additional theme-purpose in life. This study offers important new insights into the various preconditions and motives that influence working beyond retirement age. In addition, the five domains of the STREAM research framework, including the additional domain of 'purpose in life', seem to be applicable to working beyond retirement age. This knowledge contributes to the development of work-related interventions that enhance older workers' motivation to prolong their working lives.

  11. Early childhood predictors of age of initiation to use of cannabis: a birth prospective study.

    Science.gov (United States)

    Hayatbakhsh, Reza; Williams, Gail M; Bor, William; Najman, Jake M

    2013-05-01

    Early age of cannabis use predicts subsequent illicit drug abuse and other psychosocial problems. Identification of factors associated with early cannabis use may contribute to the development of preventive interventions. This study aimed to examine the early life predictors of age of initiation to cannabis. Data were from Mater Hospital and University of Queensland Study of Pregnancy, a population-based prospective birth cohort study. Participants were a cohort of 3488 young adults who self-reported frequency and age of onset of cannabis use at the 21 year follow up. Of 3488 young adults, 48.9% (51.8% men and 46.4% women) reported having ever used cannabis. For those who had ever used cannabis, age of onset had mean and median of 15.8 and 16.0 years, respectively. In multivariate analysis child's gender, change in maternal marital status, quality of marital relationship, maternal cigarette smoking and alcohol consumption and maternal depression when the child was 5 years statistically significantly predicted age of initiation to cannabis use. The present study explores the impact of early childhood factors associated with age of onset of cannabis use. It is suggested that the family environment within which children are reared, including factors such as parents' marital circumstances, has a major influence on initiation to cannabis use in adolescence. Research is needed to disentangle the pathways of association between these early life factors and early initiation to use of cannabis. © 2012 Australasian Professional Society on Alcohol and other Drugs.

  12. Positron annihilation study of ageing of an Al-Mg-Si-RE alloy

    International Nuclear Information System (INIS)

    Decheng Tian; Zhu-Xin Yu; Cai-Guo Zhan; Shao-Ling Wang

    1989-01-01

    Results of a positron lifetime study on an industrial aluminium-based alloy containing 0.65% Mg, 0.61% Si, 0.27% Fe, and 0.125% rare earths aged in a wide temperature range including the critical temperature of Guinier-Preston zone formation are presented. The hardness study shows an abrupt decrease of hardness at the aging temperature 230 0 C corresponding to formation of β-phase. Results of positron lifetime study are in consistence with those of the hardness study

  13. Age differences in coping and locus of control: a study of managerial stress in Hong Kong.

    Science.gov (United States)

    Siu, O; Cooper, C L; Spector, P E; Donald, I

    2001-12-01

    The present study involved data collection from 3 samples of Hong Kong managers to examine mechanisms by which age would relate to work well-being. A total of 634 managers was drawn by random sampling and purposive sampling methods. The results showed that age was positively related to well-being (job satisfaction and mental well-being). Furthermore, older managers reported fewer sources of stress, better coping, and a more internal locus of control. Multiple regression analyses suggested that the relations of age with 2 well-being indicators can be attributed to various combinations of coping, work locus of control, sources of stress, managerial level, and organizational tenure.

  14. Brain CT studies in 26 cases of aged patients with Down syndrome

    International Nuclear Information System (INIS)

    Arai, Yukio; Yoshihara, Sachiko; Iinuma, Kazuso.

    1995-01-01

    Computed tomographic images of brains from 26 individuals (10 males and 16 females) with Down syndrome were analysed for roentgenographic measurement. Their ages ranged from 14 to 47 years, the average being 28 years. The results showed that their Sylvian fissure ratio was larger in the aged group. A high incidence of calcification in basal ganglia, choroid plexus and pineal body was noted (85%). An increased Sylvian fissure ratio and a high incidence of intracranial calcification may be practically used as representatives of premature aging. Furthermore, a high incidence of mega cisterna magna implicates that it is worthy of study whether individuals with Down syndrome have a predisposition to underdevelopment of cerebellum. (author)

  15. An in vivo study on brain microstructure in biological and chronological ageing

    DEFF Research Database (Denmark)

    Altmann-Schneider, Irmhild; de Craen, Anton J M; van den Berg-Huysmans, Annette A

    2015-01-01

    phenotype of familial longevity. Moreover, we aimed to describe cerebral ageing effects on MTI parameters in an elderly cohort. All subjects were included from the Leiden Longevity Study and underwent 3 Tesla MTI of the brain. In total, 183 offspring of nonagenarian siblings, who are enriched for familial...... factors of longevity, were contrasted with 163 environmentally and age-matched controls. No differences in cortical and subcortical gray matter and white matter MTI parameters were found between offspring and control subjects using histogram-based and voxel-wise analyses. Cortical gray matter and white...... matter MTI parameters decreased with increasing chronological age (all p

  16. Study and prediction model on low temperature aging embrittlement in duplex stainless steels

    International Nuclear Information System (INIS)

    Sanchez, L.; Gutierrez-Solana, F.

    1997-01-01

    Within the framework of a general study on low temperature (280-400 degree centigree) aging embrittlement in duplex stainless steels, a relationship has been obtained between aging, measured from ferrite hardness evolution, and bulk materials embrittlement, determined from fracture toughness and fracture impact tests. The existing correlation between the increase in ferrite hardness and its percentage presence in the fracture path supports this relationship and results in the development of a prediction design model which provides the fracture resistance curves, for any aging level, based on the chemical composition and the steel's properties in an unaged state. (Author)

  17. Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons

    Directory of Open Access Journals (Sweden)

    Valerio eRizzo

    2015-01-01

    Full Text Available Several studies using vertebrate and invertebrate animal models have shown aging associated changes in brain function. Importantly, changes in soma size, loss or regression of dendrites and dendritic spines and alterations in the expression of neurotransmitter receptors in specific neurons were described. Despite this understanding, how aging impacts intrinsic properties of individual neurons or circuits that govern a defined behavior is yet to be determined. Here we discuss current understanding of specific electrophysiological changes in individual neurons and circuits during aging.

  18. Active aging - resilience and external support as modifiers of the disablement outcome: AGNES cohort study protocol.

    Science.gov (United States)

    Rantanen, Taina; Saajanaho, Milla; Karavirta, Laura; Siltanen, Sini; Rantakokko, Merja; Viljanen, Anne; Rantalainen, Timo; Pynnönen, Katja; Karvonen, Anu; Lisko, Inna; Palmberg, Lotta; Eronen, Johanna; Palonen, Eeva-Maija; Hinrichs, Timo; Kauppinen, Markku; Kokko, Katja; Portegijs, Erja

    2018-05-02

    Population aging increases the need for knowledge on positive aspects of aging, and contributions of older people to their own wellbeing and that of others. We defined active aging as an individual's striving for elements of wellbeing with activities as per their goals, abilities and opportunities. This study examines associations of health, health behaviors, health literacy and functional abilities, environmental and social support with active aging and wellbeing. We will develop and validate assessment methods for physical activity and physical resilience suitable for research on older people, and examine their associations with active aging and wellbeing. We will examine cohort effects on functional phenotypes underlying active aging and disability. For this population-based study, we plan to recruit 1000 participants aged 75, 80 or 85 years living in central Finland, by drawing personal details from the population register. Participants are interviewed on active aging, wellbeing, disability, environmental and social support, mobility, health behavior and health literacy. Physical activity and heart rate are monitored for 7 days with wearable sensors. Functional tests include hearing, vision, muscle strength, reaction time, exercise tolerance, mobility, and cognitive performance. Clinical examination by a nurse and physician includes an electrocardiogram, tests of blood pressure, orthostatic regulation, arterial stiffness, and lung function, as well as a review of chronic and acute conditions and prescribed medications. C-reactive protein, small blood count, cholesterol and vitamin D are analyzed from blood samples. Associations of factors potentially underlying active aging and wellbeing will be studied using multivariate methods. Cohort effects will be studied by comparing test results of physical and cognitive functioning with results of a cohort examined in 1989-90. The current study will renew research on positive gerontology through the novel approach to

  19. Internal migration and regional differences of population aging: An empirical study of 287 cities in China.

    Science.gov (United States)

    Chen, Rong; Xu, Ping; Li, Fen; Song, Peipei

    2018-04-02

    In addition to birth and death, migration is also an important factor that determines the level of population aging in different regions, especially under the current context of low fertility and low mortality in China. Drawing upon data from the fifth and sixth national population census of 287 prefecture-level cities in China, this study explored the spatial patterns of population aging and its trends from 2000 to 2010 in China. We further examined how the large-scale internal migration was related to the spatial differences and the changes of aging by using multivariate quantitative models. Findings showed that the percentage of elder cities (i.e. proportion of individuals aged 65 and above to total population is higher than 7%) increased from 50% to 90% in the total 287 cities within the decade. We also found that regional imbalances of population aging have changed since 2000 in China. The gap of aging level between East zone and the other three zones (i.e. West, Central, and North-east) has considerably narrowed down. In 2000, Eastern region had the greatest number (65) of and the largest proportion (74.7%) of elder cities among all four regions. By 2010, the proportion (87.4%) of elder cities in the eastern region was slightly lower than Central (91.4%), Western (88.2%) and North-east sectors (91.2%). Results from multivariate quantitative models showed that the regional differences of population aging appear to be affected much more by the large-scale internal migration with clear age selectivity and orientation preference than by the impact of fertility and mortality. Population aging is expected to continue in China, which will in turn exacerbate regional imbalances. Policies and implications are discussed to face the challenges that the divergent aging population may present in China.

  20. Successful mental health aging: results from a longitudinal study of older Australian men.

    Science.gov (United States)

    Almeida, Osvaldo P; Norman, Paul; Hankey, Graeme; Jamrozik, Konrad; Flicker, Leon

    2006-01-01

    The authors investigated the associations of medical and lifestyle factors with the mental health of men in their 80s. This was a prospective study of a community-representative cohort of older men. Successful mental health aging was defined as reaching age 80 years with Mini-Mental State Examination score (MMSE) of 24 or more and Geriatric Depression Scale-15 items (GDS-15) score of 5 or less. Of 601 men followed for 4.8 years, 76.0% enjoyed successful mental health aging. Successful mental health aging was inversely associated with age (hazard ratio [HR] = 0.87; 95% confidence interval [CI]: 0.81-0.94), non-English-speaking background (HR = 0.42; 95% CI: 0.21-0.85), and the consumption of full-cream milk (HR = 0.63; 95% CI: 0.45-0.89), and directly associated with high school or university education (HR = 1.92; 95% CI: 1.34-2.75) and vigorous (HR = 1.89; 95% CI: 1.17-3.05) and nonvigorous physical activity (HR = 1.50; 95% CI: 1.05-2.14). Marital status, smoking and alcohol use, weekly consumption of meat or fish, and a medical history of hypercholesterolemia, hypertension, diabetes, myocardial infarction, and stroke were not associated with mental health outcomes in men aged 80 years or over. Three in four men who reach age 80 years undergo successful mental health aging. Factors associated with successful mental health aging include education and lifestyle behaviors such as physical activity. Lifestyle modification by means of increasing physical activity and reducing saturated fat intake may prove to be a safe, inexpensive, and readily available strategy to help maximize the successful mental health aging of the population.

  1. Successful ageing: A study of the literature using citation network analysis.

    Science.gov (United States)

    Kusumastuti, Sasmita; Derks, Marloes G M; Tellier, Siri; Di Nucci, Ezio; Lund, Rikke; Mortensen, Erik Lykke; Westendorp, Rudi G J

    2016-11-01

    Ageing is accompanied by an increased risk of disease and a loss of functioning on several bodily and mental domains and some argue that maintaining health and functioning is essential for a successful old age. Paradoxically, studies have shown that overall wellbeing follows a curvilinear pattern with the lowest point at middle age but increases thereafter up to very old age. To shed further light on this paradox, we reviewed the existing literature on how scholars define successful ageing and how they weigh the contribution of health and functioning to define success. We performed a novel, hypothesis-free and quantitative analysis of citation networks exploring the literature on successful ageing that exists in the Web of Science Core Collection Database using the CitNetExplorer software. Outcomes were visualized using timeline-based citation patterns. The clusters and sub-clusters of citation networks identified were starting points for in-depth qualitative analysis. Within the literature from 1902 through 2015, two distinct citation networks were identified. The first cluster had 1146 publications and 3946 citation links. It focused on successful ageing from the perspective of older persons themselves. Analysis of the various sub-clusters emphasized the importance of coping strategies, psycho-social engagement, and cultural differences. The second cluster had 609 publications and 1682 citation links and viewed successful ageing based on the objective measurements as determined by researchers. Subsequent sub-clustering analysis pointed to different domains of functioning and various ways of assessment. In the current literature two mutually exclusive concepts of successful ageing are circulating that depend on whether the individual himself or an outsider judges the situation. These different points of view help to explain the disability paradox, as successful ageing lies in the eyes of the beholder. Copyright © 2016 The Authors. Published by Elsevier Ireland

  2. Can Survival Bias Explain the Age Attenuation of Racial Inequalities in Stroke Incidence?: A Simulation Study.

    Science.gov (United States)

    Mayeda, Elizabeth Rose; Banack, Hailey R; Bibbins-Domingo, Kirsten; Zeki Al Hazzouri, Adina; Marden, Jessica R; Whitmer, Rachel A; Glymour, M Maria

    2018-07-01

    In middle age, stroke incidence is higher among black than white Americans. For unknown reasons, this inequality decreases and reverses with age. We conducted simulations to evaluate whether selective survival could account for observed age patterning of black-white stroke inequalities. We simulated birth cohorts of 20,000 blacks and 20,000 whites with survival distributions based on US life tables for the 1919-1921 birth cohort. We generated stroke incidence rates for ages 45-94 years using Reasons for Geographic and Racial Disparities in Stroke (REGARDS) study rates for whites and setting the effect of black race on stroke to incidence rate difference (IRD) = 20/10,000 person-years at all ages, the inequality observed at younger ages in REGARDS. We compared observed age-specific stroke incidence across scenarios, varying effects of U, representing unobserved factors influencing mortality and stroke risk. Despite a constant adverse effect of black race on stroke risk, the observed black-white inequality in stroke incidence attenuated at older age. When the hazard ratio for U on stroke was 1.5 for both blacks and whites, but U only directly influenced mortality for blacks (hazard ratio for U on mortality =1.5 for blacks; 1.0 for whites), stroke incidence rates in late life were lower among blacks (average observed IRD = -43/10,000 person-years at ages 85-94 years versus causal IRD = 20/10,000 person-years) and mirrored patterns observed in REGARDS. A relatively moderate unmeasured common cause of stroke and survival could fully account for observed age attenuation of racial inequalities in stroke.

  3. Life style and longevity among initially healthy middle-aged men: prospective cohort study.

    Science.gov (United States)

    Heir, Trond; Erikssen, Jan; Sandvik, Leiv

    2013-09-11

    Few studies have examined how various lifestyle factors in midlife predict longevity, and none of these studies have examined the impact of physical fitness. The present study aimed to examine longevity in relation to smoking, overweight and physical fitness. We prospectively studied longevity (defined as reaching at least 85 years of age) in relation to smoking status, body mass index and physical fitness in 821 healthy men between 51 and 59 years of age. Of these, 369 were smokers, 320 were overweight, and 31 were obese. The associations were adjusted for age, systolic blood pressure and cholesterol level, using multivariate logistic regression analysis. Deaths were registered until the 31st of December, 2006. Physical fitness was measured as the total work performed in a maximal exercise tolerance bicycle test. 252 men survived to the age of 85 years (30.7%). Smoking status was significantly and independently related to longevity; 37.2% of the non-smokers survived to the age of 85, and 22.8% of the smokers. Among non-smokers, overweight and physical fitness were significantly and independently related to longevity after adjustment for age, blood pressure and cholesterol level, but not among smokers. Among non-smokers with high physical fitness, 48.8% reached the age of 85 years, compared to 27.9% among non-smokers with low physical fitness. Lifestyle variables appear to be strong and independent predictors of longevity in initially healthy middle-aged men. The probability of longevity may be a useful concept when informing the general public about the benefits of a healthy lifestyle.

  4. Accumulation of advanced glycation end (AGEs products in intensive care patients: an observational, prospective study

    Directory of Open Access Journals (Sweden)

    Rommes Johannes H

    2010-05-01

    Full Text Available Abstract Background Oxidative stress plays an important role in the course and eventual outcome in a majority of patients admitted to the intensive care unit (ICU. Markers to estimate oxidative stress are not readily available in a clinical setting. AGEs accumulation has been merely described in chronic conditions, but can also occur acutely due to oxidative stress. Since AGEs have emerged to be stable end products, these can be a marker of oxidative stress. Skin autofluorescence (AF is a validated marker of tissue content of AGEs. We hypothesized that AGEs accumulate acutely in ICU patients. Methods We performed an observational prospective study in a medical surgical ICU in a university affiliated teaching hospital. All consecutively admitted ICU patients in a 2 month period were included. Skin AF was measured using an AGE reader in 35 consecutive ICU patients > 18 yrs. As a comparison, historical data of a control group (n = 231 were used. These were also used to calculate age-adjusted AF-levels (AFadj. Values are expressed as median and interquartile range [P25-P75]. Differences between groups were tested by non parametric tests. P Results AFadj values were higher in ICU patients (0.33 [0.00 - 0.68] than in controls (-0.07 [-0.29 - 0.24]; P adj were observed between acute or planned admissions, or presence of sepsis, nor was skin AFadj related to severity of disease as estimated by APACHE-II score, length of ICU, hospital stay or mortality. Conclusion Acute AGE accumulation in ICU patients was shown in this study, although group size was small. This can possibly reflect oxidative stress in ICU patients. Further studies should reveal whether AGE-accumulation will be a useful parameter in ICU patients and whether skin AF has a predictive value for outcome, which was not shown in this small study.

  5. Influence of memory, attention, IQ and age on auditory temporal processing tests: preliminary study

    OpenAIRE

    Murphy, Cristina Ferraz Borges; Zachi, Elaine Cristina; Roque, Daniela Tsubota; Ventura, Dora Selma Fix; Schochat, Eliane

    2014-01-01

    PURPOSE: To investigate the existence of correlations between the performance of children in auditory temporal tests (Frequency Pattern and Gaps in Noise - GIN) and IQ, attention, memory and age measurements. METHOD: Fifteen typically developing individuals between the ages of 7 to 12 years and normal hearing participated in the study. Auditory temporal processing tests (GIN and Frequency Pattern), as well as a Memory test (Digit Span), Attention tests (auditory and visual modality) and ...

  6. A study of personality in children aged 8-12 years: Comparing self- and partents' ratings

    OpenAIRE

    Quartier, V.; Rossier, J.

    2008-01-01

    This study was designed to investigate personality development with children aged 8 to 12. For this purpose, Children's self-perceptions were compared to parent's ratings. 506 children and their parents completed a selection of 38 questions from the Hierarchical Personality Inventory for Children (HiPIC). Results showed an age-related increase in the structural congruence of children's ratings compared to parents' ratings and a highly significant increase in the reliabilities of both parents'...

  7. A Study of Correlation of Various Growth Indicators with Chronological Age

    OpenAIRE

    Singh, Sarabjeet; Sandhu, Navreet; Puri, Taruna; Gulati, Ritika; Kashyap, Rita

    2015-01-01

    ABSTRACT Introduction: The aim of this study was to assess the relationship of chronological age with cervical vertebrae skeletal maturation, frontal sinus width and antegonial notch depth and a correlation, if any, among the three variables. Materials and methods: The samples were derived from lateral cephalometric radiographs of 80 subjects (40 males, 40 females; age range: 10 to 19 years). Cervical vertebral development was evaluated by the method of Hassel and Farman, frontal sinus width ...

  8. Age at menopause and incident heart failure: the Multi-Ethnic Study of Atherosclerosis.

    Science.gov (United States)

    Ebong, Imo A; Watson, Karol E; Goff, David C; Bluemke, David A; Srikanthan, Preethi; Horwich, Tamara; Bertoni, Alain G

    2014-06-01

    This study aims to evaluate the associations of early menopause (menopause occurring before age 45 years) and age at menopause with incident heart failure (HF) in postmenopausal women. We also explored the associations of early menopause and age at menopause with left ventricular (LV) measures of structure and function in postmenopausal women. We included 2,947 postmenopausal women, aged 45 to 84 years without known cardiovascular disease (2000-2002), from the Multi-Ethnic Study of Atherosclerosis. Cox proportional hazards models were used to examine the associations of early menopause and age at menopause with incident HF. In 2,123 postmenopausal women in whom cardiac magnetic resonance imaging was obtained at baseline, we explored the associations of early menopause and age at menopause with LV measures using multivariable linear regression. Across a median follow-up of 8.5 years, we observed 71 HF events. There were no significant interactions with ethnicity for incident HF (Pinteraction > 0.05). In adjusted analysis, early menopause was associated with an increased risk of incident HF (hazard ratio, 1.66; 95% CI, 1.01-2.73), whereas every 1-year increase in age at menopause was associated with a decreased risk of incident HF (hazard ratio, 0.96; 95% CI, 0.94-0.99). We observed significant interactions between early menopause and ethnicity for LV mass-to-volume ratio (LVMVR; Pinteraction = 0.02). In Chinese-American women, early menopause was associated with a higher LVMVR (+0.11; P = 0.0002), whereas every 1-year increase in age at menopause was associated with a lower LVMVR (-0.004; P = 0.04) at baseline. Older age at menopause is independently associated with a decreased risk of incident HF. Concentric LV remodeling, indicated by a higher LVMVR, is present in Chinese-American women who experienced early menopause at baseline.

  9. Longitudinal and cross-sectional changes with age in selected anthropometric and physiological traits in hospitalized adults: an insight from the Polish Longitudinal Study of Aging (PLSA

    Directory of Open Access Journals (Sweden)

    Chmielewski Piotr

    2015-12-01

    Full Text Available Longitudinal studies of aging concerning individuals with comparable lifestyle, diet, health profile, socioeconomic status, and income remain extraordinarily rare. The purposes of our ongoing project are as follows: (i to collect extensive data on biological and medical aspects of aging in the Polish population, (ii to determine factors affecting the rate and course of aging, (iii to understand how aging unfolds as a dynamic and malleable process in ontogeny, and (iv to find novel predictors of longevity. Our investigation followed 142 physically healthy asylum inmates, including 68 males and 74 females, for at least 25 years from the age of 45 years onward. Cross-sectional assessment involved 225 inmates, including 113 males and 112 females. All the patients lived for a very long time under similar and good environmental conditions at the hospital in Cibórz, Lubuskie Province. They maintained virtually the same daily schedule and lifestyle. The rate and direction of changes with age in selected anthropometric and physiological traits were determined using ANOVA, t-test, and regression analysis. There were sex differences in the rate and pattern of age-related changes in certain characteristics such as relative weight, red blood cell count, monocyte count, thymol turbidity value, systolic blood pressure, and body temperature. Body weight, the body mass index (BMI, and total bilirubin level increased with advancing age, while body height decreased with age in both sexes. In conclusion, the aging process was associated with many regressive alterations in biological traits in both sexes but the rate and pattern of these changes depended on biological factors such as age and sex. There were only few characteristics which did not change significantly during the period under study. On the basis of comparison between the pattern of longitudinal changes with aging and the pattern of cross-sectional changes with age in the analyzed traits, we were able

  10. Towards measurement of the Healthy Ageing Phenotype in lifestyle-based intervention studies.

    Science.gov (United States)

    Lara, Jose; Godfrey, Alan; Evans, Elizabeth; Heaven, Ben; Brown, Laura J E; Barron, Evelyn; Rochester, Lynn; Meyer, Thomas D; Mathers, John C

    2013-10-01

    Given the biological complexity of the ageing process, there is no single, simple and reliable measure of how healthily someone is ageing. Intervention studies need a panel of measures which capture key features of healthy ageing. To help guide our research in this area, we have adopted the concept of the "Healthy Ageing Phenotype" (HAP) and this study aimed to (i) identify the most important features of the HAP and (ii) identify/develop tools for measurement of those features. After a comprehensive assessment of the literature we selected the following domains: physiological and metabolic health, physical capability, cognitive function, social wellbeing, and psychological wellbeing which we hoped would provide a reasonably holistic characterisation of the HAP. We reviewed the literature and identified systematic reviews and/or meta-analysis of cohort studies, and clinical guidelines on outcome measures of these domains relevant to the HAP. Selection criteria for these measures included: frequent use in longitudinal studies of ageing; expected to change with age; evidence for strong association with/prediction of ageing-related phenotypes such as morbidity, mortality and lifespan; whenever possible, focus on studies measuring these outcomes in populations rather than on individuals selected on the basis of a particular disease; (bio)markers that respond to (lifestyle-based) intervention. Proposed markers were exposed to critique in a Workshop held in Newcastle, UK in October 2012. We have selected a tentative panel of (bio)markers of physiological and metabolic health, physical capability, cognitive function, social wellbeing, and psychological wellbeing which we propose may be useful in characterising the HAP and which may have utility as outcome measures in intervention studies. In addition, we have identified a number of tools which could be applied in community-based intervention studies designed to enhance healthy ageing. We have proposed, tentatively, a panel

  11. Older adults' perceptions of ageing and their health and functioning: a systematic review of observational studies.

    Science.gov (United States)

    Warmoth, Krystal; Tarrant, Mark; Abraham, Charles; Lang, Iain A

    2016-07-01

    Many older people perceive ageing negatively, describing it in terms of poor or declining health and functioning. These perceptions may be related to older adults' health. The aim of this review was to synthesise existing research on the relationship between older adults' perceptions of ageing and their health and functioning. A systematic search was conducted of five electronic databases (ASSIA, CINAHL, IBSS, MEDLINE and PsycINFO). Citations within identified reports were also searched. Observational studies were included if they included perceptions of ageing and health-related measures involving participants aged 60 years and older. Study selection, data extraction and quality appraisal were conducted using predefined criteria. Twenty-eight reports met the criteria for inclusion. Older adults' perceptions of ageing were assessed with a variety of measures. Perceptions were related to health and functioning across seven health domains: memory and cognitive performance, physical and physiological performance, medical conditions and outcomes, disability, care-seeking, self-rated health, quality of life and death. How ageing is perceived by older adults is related to their health and functioning in multiple domains. However, higher quality and longitudinal studies are needed to further investigate this relationship.

  12. Demirjian's method in the estimation of age: A study on human third molars.

    Science.gov (United States)

    Lewis, Amitha J; Boaz, Karen; Nagesh, K R; Srikant, N; Gupta, Neha; Nandita, K P; Manaktala, Nidhi

    2015-01-01

    The primary aim of the following study is to estimate the chronological age based on the stages of third molar development following the eight stages (A to H) method of Demirjian et al. (along with two modifications-Orhan) and secondary aim is to compare third molar development with sex and age. The sample consisted of 115 orthopantomograms from South Indian subjects with known chronological age and gender. Multiple regression analysis was performed with chronological age as the dependable variable and third molar root development as independent variable. All the statistical analysis was performed using the SPSS 11.0 package (IBM ® Corporation). Statistically no significant differences were found in third molar development between males and females. Depending on the available number of wisdom teeth in an individual, R (2) varied for males from 0.21 to 0.48 and for females from 0.16 to 0.38. New equations were derived for estimating the chronological age. The chronological age of a South Indian individual between 14 and 22 years may be estimated based on the regression formulae. However, additional studies with a larger study population must be conducted to meet the need for population-based information on third molar development.

  13. Stressors of School-age Children With Allergic Diseases: A Qualitative Study.

    Science.gov (United States)

    Iio, Misa; Hamaguchi, Mana; Nagata, Mayumi; Yoshida, Koichi

    2018-05-08

    Most studies of stress in children with chronic diseases have been geared toward parents and caregivers have not considered allergic diseases together. This study aimed to identify the stressors associated with allergic diseases in Japanese school-age children. Stressors associated with allergic diseases of 11 school-age children (seven boys and four girls; age range: 9-12 years) were investigated using semi-structured interviews. In the qualitative thematic analysis of stressors about allergic diseases, two themes: allergic disease-specific stressors and common stressors in chronic diseases, and 12 categories were identified. A thematic map was applied to four domains of stressor: physiological factors, psychological factors, social factors, and environmental factors. The results showed that school-age children with allergic diseases have a variety of stressors. Future studies should aim to develop an allergic disease-specific stress management program with school-age children. In children with allergic diseases, not only is stress management in daily life important, but also stress management for disease-specific matters to control the symptoms and maintain mental health. Stress management should be supported for school-age children with allergic diseases. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses

    Directory of Open Access Journals (Sweden)

    Jenna M. Bartley

    2017-09-01

    exploratory studies highlight the impact of caloric restriction on fecal microbiome in both young and aged animals, as well as the many complex relationships between flu responses and gut microbiota. Thus, these preliminary studies provide the necessary groundwork to examine how gut microbiota alterations may be leveraged to influence declining immune responses with aging.

  15. Self-esteem development from young adulthood to old age: a cohort-sequential longitudinal study.

    Science.gov (United States)

    Orth, Ulrich; Trzesniewski, Kali H; Robins, Richard W

    2010-04-01

    The authors examined the development of self-esteem from young adulthood to old age. Data came from the Americans' Changing Lives study, which includes 4 assessments across a 16-year period of a nationally representative sample of 3,617 individuals aged 25 years to 104 years. Latent growth curve analyses indicated that self-esteem follows a quadratic trajectory across the adult life span, increasing during young and middle adulthood, reaching a peak at about age 60 years, and then declining in old age. No cohort differences in the self-esteem trajectory were found. Women had lower self-esteem than did men in young adulthood, but their trajectories converged in old age. Whites and Blacks had similar trajectories in young and middle adulthood, but the self-esteem of Blacks declined more sharply in old age than did the self-esteem of Whites. More educated individuals had higher self-esteem than did less educated individuals, but their trajectories were similar. Moreover, the results suggested that changes in socioeconomic status and physical health account for the decline in self-esteem that occurs in old age.

  16. Age as a determinant of nutritional status: A cross sectional study

    Directory of Open Access Journals (Sweden)

    Gariballa Salah

    2005-10-01

    Full Text Available Abstract Background Undenutrition is known to be prevalent and largely unrecognised in older patients; however, aberrations in indicators of nutritional status may simply reflect effects of age and/or functional disability. Objective The aim of this study was to measure the effect, if any of age on nutritional status in older patients. Design 445 randomly selected hospitalised patients consented to nutritional status assessment derived from anthropometric, haematological, and biochemical data within 72 hours of admission. Nutritional status was compared between those age Results Body weight, body mass index, mid-upper arm circumference, haemoglobin, serum albumin and plasma ascorbic acid were all significantly lower in people aged ≥ 75 years compared with those 3, red-cell folate and vitamin B12 concentrations were lower in those aged ≥ 75 years, differences were not statistically significant. After adjusting for disability and co-morbidity in a multivariate analysis, age alone had a significant and independent effect on important anthropometric and biochemical nutritional assessment variables. Conclusion Increasing age is independently associated with poor nutritional status. This may partly explain the poor clinical outcome in older patients.

  17. Evaluation of third molar development and its relation to chronological age: a panoramic radiographic study.

    Science.gov (United States)

    Zandi, Mohammad; Shokri, Abbas; Malekzadeh, Hamid; Amini, Payam; Shafiey, Parastu

    2015-06-01

    Third molar development, in comparison to other teeth in the dentition, has the greatest variation in morphology, anatomical position, and time of development and eruption, and its reliability for chronological age estimation is controversial. The aim of the present study was to evaluate third molar development and its relation to chronological age using panoramic radiography. A total of 2536 digital panoramic radiographs of individuals aged between 5 and 26 years were selected. The developmental status of the third molars was assessed using eight-stage developmental scoring proposed by Demirjian et al., with one modification: a stage 0 was added. The collected data were entered into a checklist and subjected to statistical analyses. The mean ages of the first appearance of third molar bud, complete crown formation, and root apex closure were around 9, 14, and 22 years, respectively. In both jaws, third molar development occurred symmetrically, and sexual dimorphism was observed at some developmental stages. Finally, two formulas were presented to estimate age of the juveniles and adolescents based on their gender and developmental stages of the third molars, and validated on a second sample consisting of 523 individuals aged between 8 and 22. Assessment of third molar development was found to be a reliable method for age estimation of individuals between 11 and 22 years. Because of possible ethnic and geographic differences in third molar development, population specific researches were recommended.

  18. A longitudinal study of structural brain network changes with normal aging

    Directory of Open Access Journals (Sweden)

    Kai eWu

    2013-04-01

    Full Text Available The aim of this study was to investigate age-related changes in the topological organization of structural brain networks by applying a longitudinal design over 6 years. Structural brain networks were derived from measurements of regional gray matter volume and were constructed in age-specific groups from baseline and follow-up scans. The structural brain networks showed economical small-world properties, providing high global and local efficiency for parallel information processing at low connection costs. In the analysis of the global network properties, the local and global efficiency of the baseline scan were significantly lower compared to the follow-up scan. Moreover, the annual rate of changes in local and global efficiency showed a positive and negative quadratic correlation with the baseline age, respectively; both curvilinear correlations peaked at approximately the age of 50. In the analysis of the regional nodal properties, significant negative correlations between the annual rate of changes in nodal strength and the baseline age were found in the brain regions primarily involved in the visual and motor/ control systems, whereas significant positive quadratic correlations were found in the brain regions predominately associated with the default-mode, attention, and memory systems. The results of the longitudinal study are consistent with the findings of our previous cross-sectional study: the structural brain networks develop into a fast distribution from young to middle age (approximately 50 years old and eventually became a fast localization in the old age. Our findings elucidate the network topology of structural brain networks and its longitudinal changes, thus enhancing the understanding of the underlying physiology of normal aging in the human brain.

  19. Aging affects the interaction between attentional control and source memory: an fMRI study.

    Science.gov (United States)

    Dulas, Michael R; Duarte, Audrey

    2014-12-01

    Age-related source memory impairments may be due, at least in part, to deficits in executive processes mediated by the PFC at both study and test. Behavioral work suggests that providing environmental support at encoding, such as directing attention toward item-source associations, may improve source memory and reduce age-related deficits in the recruitment of these executive processes. The present fMRI study investigated the effects of directed attention and aging on source memory encoding and retrieval. At study, participants were shown pictures of objects. They were either asked to attend to the objects and their color (source) or to their size. At test, participants determined if objects were seen before, and if so, whether they were the same color as previously. Behavioral results showed that direction of attention improved source memory for both groups; however, age-related deficits persisted. fMRI results revealed that, across groups, direction of attention facilitated medial temporal lobe-mediated contextual binding processes during study and attenuated right PFC postretrieval monitoring effects at test. However, persistent age-related source memory deficits may be related to increased recruitment of medial anterior PFC during encoding, indicative of self-referential processing, as well as underrecruitment of lateral anterior PFC-mediated relational processes. Taken together, this study suggests that, even when supported, older adults may fail to selectively encode goal-relevant contextual details supporting source memory performance.

  20. Microstructural evolution during isothermal aging and strain-induced transformation followed by isothermal aging in Co-Cr-Mo-C alloy: A comparative study

    International Nuclear Information System (INIS)

    Lashgari, H.R.; Zangeneh, Sh.; Hasanabadi, F.; Saghafi, M.

    2010-01-01

    The present study was undertaken to investigate the effects of isothermal aging (at 850 deg. C for 4, 8, 16 and 24 h) and strain-induced transformation (engineering strains of 10% and 20%) followed by isothermal aging (at 850 deg. C for 4, 8 and 16 h) on the microstructural evolution of a Co-28Cr-5Mo-0.3C alloy. The obtained results showed that isothermal aging at 850 deg. C resulted in the formation of lamellar-type carbides at the grain boundaries. Moreover, X-ray diffraction analysis indicated that isothermal aging of solution treated specimens at 850 deg. C for 24 h did not lead to complete fcc phase transformation to hcp one. In contrast with the isothermally aged specimens, applying plastic deformation to the solutionized samples accelerated the completion and saturation of fcc(metastable) → hcp transformation after 8 h aging at 850 deg. C. In addition, the X-ray diffraction results indicated that implementing isothermal aging of the strain-induced specimens at the higher aging time (16 h) caused the formation of (1 1 1) fcc and (2 0 0) fcc diffraction peaks again. Also, the strain-induced specimens followed by isothermal aging showed higher amount of microhardness as compared with the other specimens aged solely.

  1. Does eating particular diets alter risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements?

    Science.gov (United States)

    Background: Recent information suggests that the Age-Related Eye Disease Study (AREDS) supplement, enhanced intake of omega-3 fatty acids, and diminishing dietary glycemic index (dGI) are protective against advanced age-related macular degeneration (AMD). Methods: Dietary information was collected a...

  2. Physical activity, healthy diet and good cognitive functioning: findings from the longitudinal aging study Amsterdam

    NARCIS (Netherlands)

    Nijholt, Willemke; Jager-Wittenaar, Harriët; Visser, M.; Hobbelen, Hans

    2014-01-01

    Background. In an ageing society cognitive decline is expected to become an important health problem. Previous studies showed that a healthy lifestyle, i.e. sufficient physical activity and a healthy diet,can benefit cognitive function. In this study, we aimed to assess the (synergistic) association

  3. Parents' posttraumatic stress after burns in their school-aged child : A prospective study

    NARCIS (Netherlands)

    Egberts, Marthe R|info:eu-repo/dai/nl/412493616; van de Schoot, A.G.J.|info:eu-repo/dai/nl/304833207; Geenen, R.|info:eu-repo/dai/nl/087017571; Van Loey, Nancy E E

    OBJECTIVE: This prospective study examined the course and potential predictors of parents' posttraumatic stress symptoms (PTSS) after burn injury in their child (Age 8 to 18 years). METHOD: One hundred eleven mothers and 91 fathers, representing 118 children, participated in the study. Within the

  4. The Perceived Impact of Playing Music while Studying: Age and Cultural Differences

    Science.gov (United States)

    Kotsopoulou, Anastasia; Hallam, Susan

    2010-01-01

    Rating scale questionnaires were administered to 600 students in three age groups, 12-13, 15-16 and 20-21 from Japan, the UK, Greece and the USA. The questionnaires explored the extent of playing music while studying, the kinds of tasks when music was played, the perceived effects of music on studying, the characteristics and types of music played…

  5. Learn with the Classics: Using Music To Study Smart at Any Age.

    Science.gov (United States)

    Andersen, Ole; Marsh, Marcy; Harvey, Arthur

    This book, accompanied by a musical CD-ROM, provides information on how to enhance learning through music at any age. Sections include: (1) "Let Music Prime Your Brain For Learning," which teaches how important it is to prime the brain for learning through music; (2) "Study Smart," which demonstrates highly effective studying techniques devised by…

  6. The Temporal Relation Between Pain and Depression : Results From the Longitudinal Aging Study Amsterdam

    NARCIS (Netherlands)

    Hilderink, Peter H.; Burger, Huibert; Deeg, Dorly J.; Beekman, Aartjan T.; Voshaar, Richard C. Oude

    2012-01-01

    Objective: Pain and depression are both common in old age, but their (long-term) temporal relationship remains unknown. This study is designed to determine whether pain predicts the onset of depression and vice versa. Methods: This is a prospective, population-based cohort study with 12-year

  7. Reasons for Discontinuing Study: The Case of Mature Age Female Students with Children.

    Science.gov (United States)

    Scott, Catherine; And Others

    1996-01-01

    A study of 118 adult women students, with children, in 3 Australian universities found 3 major factors in withdrawal: socioeconomic class (lack of family support for mother's study, lack of money, domestic responsibilities, lack of needed skills); nontraditional major (economics, business, law); and age (younger students because of family or…

  8. Age-related changes in the macula. A histopathological study of fifty Indian donor eyes.

    Science.gov (United States)

    Biswas, Jyotirmay; Raman, Rajiv

    2002-09-01

    Age-related macular degeneration (ARMD) is clinically less common in India compared to the West. Therefore, clinicians are unfamiliar with histopathologic evidence of age-related macular changes in the Indian population. Fifty consecutive human donor eyes removed for corneal grafting were studied for gross, microscopic and histochemical features of age-related changes in the macula in the Indian population. A horizontal block was cut from the globe including the optic disc, and the macula. Six sections, 6 microns thick, were cut from three levels in the macula at a distance of 140 microns. These were stained with haemotoxylin-eosin, periodic acid-Schiff, Mallory, Masson trichrome, alcian blue and von Kossa stains. The presence of basal laminar deposits, drusen and thickening and calcification of Bruch's membrane in the macula were assessed at 400 x magnification using a modified version of Sark's classification. Twenty-four donor eyes (48%) had some form of age-related macular change. These included basal laminar deposits, hard drusen, soft drusen, extensive retinal pigment epithelium atrophy of the macula, and disciform degeneration of macula. A combination of changes was often seen. Age-related changes were more common in the seventh and eighth decade. Our study shows that histological changes characteristic of the early stages of age-related macular degeneration are fairly common in the Indian population. However, advanced macular changes are significantly rare.

  9. Challenges and motivators to physical activity faced by retired men when ageing: a qualitative study.

    Science.gov (United States)

    Bredland, Ebba Langum; Söderström, Sylvia; Vik, Kjersti

    2018-05-15

    Active ageing reflects the message from World Health Organisation about addressing the challenge faced by the rapidly ageing population. Knowledge about barriers and facilitators to an active lifestyle must be given more attention. In addition, men seem to participate less in cultural activities and less in fall-prevention groups than women do. When mostly women work with the elderly in primary care, one might question whether the activities offered to older men meet their activity preferences. The aim of this study is to provide new knowledge about challenges and motivators encountered by retired men in maintaining physical activity when ageing. Nine retired men, aged between 66 and 83, wrote a Time Geographic Diary for 7 days each. Two focus group discussions with the men were held. A Systemic Text Condensation was used to analyse the data. The analyses identified three categories to describe challenges in being physical active: differences between men and women; meaningful physical activity; and environmental - especially socio-cultural - constraints. Motivating conditions were seen as: new activities to get younger friends, and more information about how to cope. To achieve the aim of active ageing, service providers as well as local authorities need to have a better understanding of the challenges retired men encounter when ageing. This study highlights vital aspects of the challenges faced by retired men in maintaining their physical activity level.

  10. Familial concordance for age at natural menopause: results from the Breakthrough Generations Study.

    Science.gov (United States)

    Morris, Danielle H; Jones, Michael E; Schoemaker, Minouk J; Ashworth, Alan; Swerdlow, Anthony J

    2011-09-01

    Existing estimates of the heritability of menopause age have a wide range. Furthermore, few studies have analyzed to what extent familial similarities might reflect shared environment, rather than shared genes. We therefore analyzed familial concordance for age at natural menopause and the effects of shared genetic and environmental factors on this concordance. Participants were 2,060 individuals comprising first-degree relatives, aged 31 to 90 years, and participating in the UK Breakthrough Generations Study. Menopause data were collected using a self-administered questionnaire and analyzed using logistic regression and variance-components models. Women were at an increased risk of early menopause (≤45 y) if their mother (odds ratio, 6.2; P menopause. Likewise, women had an increased risk of late menopause (≥54 y) if their relative had had a late menopause (mother: odds ratio, 6.1; P menopause age attributed to environmental factors shared by sisters. We confirm that early menopause aggregates within families and show, for the first time, that there is also strong familial concordance for late menopause. Both genes and shared environment were the source of variation in menopause age. Past heritability estimates have not accounted for shared environment, and thus, the effect of genetic variants on menopause age may previously have been overestimated.

  11. Age-related changes in the macula. A histopathological study of fifty Indian donor eyes

    Directory of Open Access Journals (Sweden)

    Biswas Jyotirmay

    2002-01-01

    Full Text Available PURPOSE: Age-related macular degeneration (ARMD is clinically less common in India compared to the West. Therefore, clinicians are unfamiliar with histopathologic evidence of age-related macular changes in the Indian population. METHODS: Fifty consecutive human donor eyes removed for corneal grafting were studied for gross, microscopic and histochemical features of age-related changes in the macula in the Indian population. A horizontal block was cut from the globe including the optic disc, and the macula. Six sections, 6 microns thick, were cut from three levels in the macula at a distance of 140 microns. These were stained with haemotoxylin-eosin, periodic acid-Schiff, Mallory, Masson trichrome, alcian blue and von Kossa stains. The presence of basal laminar deposits, drusen and thickening and calcification of Bruch′s membrane in the macula were assessed at 400 x magnification using a modified version of Sark′s classification. RESULTS: Twenty-four donor eyes (48% had some form of age-related macular change. These included basal laminar deposits, hard drusen, soft drusen, extensive retinal pigment epithelium atrophy of the macula, and disciform degeneration of macula. A combination of changes was often seen. Age-related changes were more common in the seventh and eighth decade. CONCLUSION: Our study shows that histological changes characteristic of the early stages of age-related macular degeneration are fairly common in the Indian population. However, advanced macular changes are significantly rare.

  12. Parental Predictors of Children's Shame and Guilt at Age 6 in a Multimethod, Longitudinal Study.

    Science.gov (United States)

    Parisette-Sparks, Alyssa; Bufferd, Sara J; Klein, Daniel N

    2017-01-01

    Shame and guilt are self-conscious emotions that begin to develop early in life and are associated with various forms of psychopathology. However, little is known about the factors that contribute to these emotions in young children. Specifically, no longitudinal studies to date have examined a range of parent factors that shape the expression of children's shame and guilt. The current multimethod, longitudinal study sought to determine whether parenting style, parental psychopathology, and parents' marital satisfaction assessed when children were age 3 predict expressions of shame and guilt in children at age 6. A large community sample of families (N = 446; 87.4% Caucasian) with 3-year-old children (45.7% female) was recruited through commercial mailing lists. Parent variables were assessed when children were age 3 with mother- and father-report questionnaires and a diagnostic interview. Children's expressions of shame and guilt were observed in the laboratory at age 6. Fathers', but not mothers', history of depression and permissive parenting assessed when children were age 3 predicted children's expressions of shame and guilt when children were age 6; parents' marital dissatisfaction also predicted children's shame and guilt. These findings suggest that parents, and fathers in particular, contribute to expressions of self-conscious emotions in children. These data on emotional development may be useful for better characterizing the risk and developmental pathways of psychopathology.

  13. Molecular studies of exercise, skeletal muscle, and ageing [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    James A. Timmons

    2016-06-01

    Full Text Available The purpose of an F1000 review is to reflect on the bigger picture, exploring controversies and new concepts as well as providing opinion as to what is limiting progress in a particular field. We reviewed about 200 titles published in 2015 that included reference to ‘skeletal muscle, exercise, and ageing’ with the aim of identifying key articles that help progress our understanding or research capacity while identifying methodological issues which represent, in our opinion, major barriers to progress. Loss of neuromuscular function with chronological age impacts on both health and quality of life. We prioritised articles that studied human skeletal muscle within the context of age or exercise and identified new molecular observations that may explain how muscle responds to exercise or age. An important aspect of this short review is perspective: providing a view on the likely ‘size effect’ of a potential mechanism on physiological capacity or ageing.

  14. Hippocampus age-related microstructural changes in schizophrenia: a case-control mean diffusivity study.

    Science.gov (United States)

    Chiapponi, Chiara; Piras, Fabrizio; Fagioli, Sabrina; Girardi, Paolo; Caltagirone, Carlo; Spalletta, Gianfranco

    2014-08-01

    Macrostructural-volumetric abnormalities of the hippocampus have been described in schizophrenia. Here, we characterized age-related changes of hippocampal mean diffusivity as an index of microstructural damage by carrying out a neuroimaging study in 85 patients with a DSM-IV-TR diagnosis of schizophrenia and 85 age- and gender-matched healthy controls. We performed analyses of covariance, with diagnosis as fixed factor, mean diffusivity as dependent variable and age as covariate. Patients showed an early increase in mean diffusivity in the right and left hippocampus that increased with age. Thus, microstructural hippocampal changes associated with schizophrenia cannot be confined to a specific time window. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Study of the experience feedback relating to ageing of electronic component and cables

    International Nuclear Information System (INIS)

    Gauthier, G.; Henry, J.Y.

    1992-11-01

    This study was conducted on electronic components and electrical cables taken from the Brennilis EL4 reactor, during dismantling, after 18 years of operation. Its aim was to examine the state of the equipment taken from the site and thus to check its characteristics and in particular for cables: to check, whenever possible, the suitability of the accelerated ageing methods by comparing the characteristics observed on the samples from EL4 with test samples held in storage and previously subjected to similar accelerated ageing: predicting medium and long-term ageing by extrapolation from the selected mathematical model. The result of this initial work confirmed the need for extreme caution regarding the accelerated ageing methods. Further work on cables and polymers is underway and will enable the laws currently used for qualification tests to be evaluated. (author) [fr

  16. Study of the experience feedback relating to ageing of electronic components and cables

    International Nuclear Information System (INIS)

    Gauthier, G.; Henry, J.Y.

    1992-11-01

    This study was conducted on electronic components and electrical cables taken from the Brennilis EL4 reactor, during dismantling, after 18 years of operation. Its aim was to examine the state of the equipment taken from the site and thus to check its characteristics and in particular for cables: to check, whenever possible, the suitability of the accelerated ageing methods by comparing the characteristics observed on the samples from EL4 with test samples held in storage and previously subjected to similar accelerated ageing: predicting medium and long-term ageing by extrapolation from the selected mathematical model. The result of this initial work confirmed the need for extreme caution regarding the accelerated ageing methods. Further work on cables and polymers is underway and will enable the laws currently used for qualification tests to be evaluated

  17. A STUDY ON PREVALENCE AND CAUSES OF CORNEAL BLINDNESS IN PAEDIATRIC AGE GROUP

    Directory of Open Access Journals (Sweden)

    E. Ramadevi

    2017-12-01

    Full Text Available BACKGROUND Corneal disease is responsible for less than 2% of blindness in children in industrialised countries. In poor countries of the world, corneal scarring occurs due to vitamin A deficiency, measles and ophthalmia neonatorum. Thus, corneal disease is an important cause of blindness among children living in developing nations, which already carry a major burden of blindness. The aim of the study is to study the1. Prevalence of corneal blindness in the paediatric age group. 2. Causes of corneal blindness in the paediatric age group. 3. Morbidity of corneal blindness in the paediatric age group. MATERIALS AND METHODS It was cross-sectional observational study. Study Period- December 2014 to August 2016. Study Done- Government General Hospital, Kakinada. Sample Size- 50 patients. Inclusion Criteria- Children of age group 6 to 12 years with corneal blindness who have attended the outpatient department during the study period. Exclusion Criteria- Children with childhood blindness other than corneal pathology. Study Tools- Predesigned, semi-structured questionnaire regarding age, sex and age of onset of visual loss, laterality, history of ocular injury, vitamin A immunisation, family history of consanguinity and place of residence and socioeconomic status was taken. Visual acuity was measured using an E optotype and Landolt broken C chart with best corrected vision. Visual loss was classified according to the WHO categories of visual impairment. Ophthalmic examination was done by slit lamp and B scan. RESULTS Ocular trauma and corneal ulcers are most common cause of corneal blindness. 84% of corneal blindness cases were preventable and curable. CONCLUSION Trauma was the commonest cause of corneal blindness followed by infectious keratitis. 84% of corneal blindness was preventable and curable. Most causes of corneal blindness were avoidable.

  18. Aging of snubbers in nuclear service: Phase I study results and Phase II plans

    International Nuclear Information System (INIS)

    Goodman, R.L.; Bush, S.H.; Page, R.E.

    1988-01-01

    Two major research areas were investigated in the Phase I snubber aging studies. The first area involved a preliminary evaluation of the effects of various aging mechanisms on snubber operation; failure modes of mechanisms were identified and their contributions to aging degradation were assessed relative to other failure modes. The second area involved estimating the efficacy of existing tests and examinations that are intended to determine the effects of aging and degradation. Available data on snubber behavior and operating experience were reviewed, using licensee event reports and other historical data for the 10-year period from 1973 through 1983. Value-impact was considered in terms of (1) exposure of workers to radioactive environments for examination/testing and (2) the cost for expansion of the snubber testing program due to failed snubbers. Results from the Phase I studies identified the need to modify or improve examination and testing procedures to enhance snubber reliability. Based on the results of the Phase I snubber studies, the seals and fluids were identified as the two principal elements affected by aging degradation in hydraulic snubbers. Phase II work, which was initiated in FY 1987, will develop cooperative activities between PNL and operating utilities through the Snubber Utility Group (SNUG), who will work to establish a strong data and experience base for both hydraulic and mechanical snubbers based on actual operating and maintenance history at nuclear power plants. Application guidelines for snubbers will be recommended based on the study results

  19. Paternal age at birth is associated with offspring leukocyte telomere length in the nurses' health study.

    Science.gov (United States)

    Prescott, J; Du, M; Wong, J Y Y; Han, J; De Vivo, I

    2012-12-01

    Is the association between paternal age at birth and offspring leukocyte telomere length (LTL) an artifact of early life socioeconomic status (SES)? Indicators of early life SES did not alter the relationship between paternal age at birth and offspring LTL among a population of white female nurses. Telomere length is considered a highly heritable trait. Recent studies report a positive correlation between paternal age at birth and offspring LTL. Maternal age at birth has also been positively associated with offspring LTL, but may stem from the strong correlation with paternal age at birth. The Nurses' Health Study (NHS) is an ongoing prospective cohort study of 121 700 female registered nurses who were enrolled in 1976. Great effort goes into maintaining a high degree of follow-up among our cohort participants (>95% of potential person-years). In 1989-1990, a subset of 32 826 women provided blood samples from which we selected participants for several nested case-control studies of telomere length and incident chronic disease. We used existing LTL data on a total of 4250 disease-free women who also reported maternal and paternal age at birth for this study. Nested case-control studies of stroke, myocardial infarction, cancers of the breast, endometrium, skin, pancreas and colon, as well as colon adenoma, were conducted within the blood sub-cohort. Each study used the following study design: for each case of a disease diagnosed after blood collection, a risk-set sampling scheme was used to select from one to three controls from the remaining participants in the blood sub-cohort who were free of that disease when the case was diagnosed. Controls were matched to cases by age at blood collection (± 1 year), date of blood collection (± 3 months), menopausal status, recent postmenopausal hormone use at blood collection (within 3 months, except for the myocardial infarction case-control study), as well as other factors carefully chosen for each individual study. The

  20. Aging studies of resistive bulk Micromegas chambers for the ATLAS muon spectrometer upgrade

    CERN Document Server

    Spencer, Katie Louise

    2017-01-01

    A long-term operation study is presented as a probe of the aging properties of two bulk-resistive Micromegas chambers installed at the GIF$^{++}$ Gamma Irradiation Facility at CERN. Trends in the instantaneous chamber current, recorded over $\\approx$ 500 days of sustained exposure to the GIF$^{++}$ high intensity photon source, are analysed as a function of time in order to identify any signs of detector aging. As part of the study, additional variations in the current due to the changing external conditions of the chambers must be corrected for in order to isolate any aging effects. These include the changing chamber positions with respect to the photon source and the temperature and pressure fluctuations of the detector gas medium. Due to a number of subsets of the total irradiation period in which the exact detector positions are unknown, the aging study at the present time remains inconclusive. As a result, an alternative long-term aging study utilising the instantaneous chamber dark currents is suggested...

  1. Dietary compound score and risk of age-related macular degeneration in the Age-Related Eye Disease Study

    Science.gov (United States)

    Purpose: Because foods provide many nutrients, which may interact with each other to modify risk for multifactorial diseases such as age-related macular degeneration (AMD), we sought to develop a composite scoring system to summarize the combined effect of multiple dietary nutrients on AMD risk. Th...

  2. Uranium-series comminution ages of continental sediments: Case study of a Pleistocene alluvial fan

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Victoria E.; DePaolo, Donald J.; Christensen, John N.

    2010-04-30

    Obtaining quantitative information about the timescales associated with sediment transport, storage, and deposition in continental settings is important but challenging. The uranium-series comminution age method potentially provides a universal approach for direct dating of Quaternary detrital sediments, and can also provide estimates of the sediment transport and storage timescales. (The word"comminution" means"to reduce to powder," reflecting the start of the comminution age clock as reduction of lithic parent material below a critical grain size threshold of ~;;50 mu m.) To test the comminution age method as a means to date continental sediments, we applied the method to drill-core samples of the glacially-derived Kings River Fan alluvial deposits in central California. Sediments from the 45 m core have independently-estimated depositional ages of up to ~;;800 ka, based on paleomagnetism and correlations to nearby dated sediments. We characterized sequentially-leached core samples (both bulk sediment and grain size separates) for U, Nd, and Sr isotopes, grain size, surface texture, and mineralogy. In accordance with the comminution age model, where 234U is partially lost from small sediment grains due to alpha recoil, we found that (234U/238U) activity ratios generally decrease with age, depth, and specific surface area, with depletions of up to 9percent relative to radioactive equilibrium. The resulting calculated comminution ages are reasonable, although they do not exactly match age estimates from previous studies and also depend on assumptions about 234U loss rates. The results indicate that the method may be a significant addition to the sparse set of available tools for dating detrital continental sediments, following further refinement. Improving the accuracy of the method requires more advanced models or measurements for both the recoil loss factor fa and weathering effects. We discuss several independent methods for obtaining fa on individual samples

  3. Prevalence of cognitive impairment in individuals aged over 65 in an urban area: DERIVA study

    Directory of Open Access Journals (Sweden)

    Rodríguez-Sánchez Emiliano

    2011-11-01

    Full Text Available Abstract Background Few data are available on the prevalence of cognitive impairment (CI in Spain, and the existing information shows important variations depending on the geographical setting and the methodology employed. The aim of this study was to determine the prevalence of CI in individuals aged over 65 in an urban area, and to analyze its associated risk factors. Methods Design: A descriptive, cross-sectional, home questionnaire-based study; Setting: Populational, urban setting. Participants: The reference population comprised over-65s living in the city of Salamanca (Spain in 2009. Randomized sampling stratified according to health district was carried out, and a total of 480 people were selected. In all, 327 patients were interviewed (68.10%, with a mean age of 76.35 years (SD: 7.33. Women accounted for 64.5% of the total. Measurements: A home health questionnaire was used to obtain the following data: age, sex, educational level, family structure, morbidity and functionality. All participants completed a neuropsychological test battery. The prevalence data were compared with those of the European population, with direct adjustment for age and sex. Diagnoses were divided into three general categories: normal cognitive function, cognitive impairment - no dementia (CIND, and dementia. Results The prevalence of CI among these over-65s was 19% (14.7% CIND and 4.3% dementia. The age-and sex-adjusted global prevalence of CI was 14.9%. CI increased with age (p Conclusions The observed raw prevalence of CI was 19% (14.9% after adjusting for age and sex. Older age and the presence of diabetes and anxiety-depression increased the risk of CI, while higher educational level reduced the risk.

  4. Dental age assessment of young Iranian adults using third molars: A multivariate regression study.

    Science.gov (United States)

    Bagherpour, Ali; Anbiaee, Najmeh; Partovi, Parnia; Golestani, Shayan; Afzalinasab, Shakiba

    2012-10-01

    In recent years, a noticeable increase in forensic age estimations of living individuals has been observed. Radiologic assessment of the mineralisation stage of third molars is of particular importance, with regard to the relevant age group. To attain a referral database and regression equations for dental age estimation of unaccompanied minors in an Iranian population was the goal of this study. Moreover, determination was made concerning the probability of an individual being over the age of 18 in case of full third molar(s) development. Using the scoring system of Gleiser and Hunt, modified by Köhler, an investigation of a cross-sectional sample of 1274 orthopantomograms of 885 females and 389 males aged between 15 and 22 years was carried out. Using kappa statistics, intra-observer reliability was tested. With Spearman correlation coefficient, correlation between the scores of all four wisdom teeth, was evaluated. We also carried out the Wilcoxon signed-rank test on asymmetry and calculated the regression formulae. A strong intra-observer agreement was displayed by the kappa value. No significant difference (p-value for upper and lower jaws were 0.07 and 0.59, respectively) was discovered by Wilcoxon signed-rank test for left and right asymmetry. The developmental stage of upper right and upper left third molars yielded the greatest correlation coefficient. The probability of an individual being over the age of 18 is 95.6% for males and 100.0% for females in case four fully developed third molars are present. Taking into consideration gender, location and number of wisdom teeth, regression formulae were arrived at. Use of population-specific standards is recommended as a means of improving the accuracy of forensic age estimates based on third molars mineralisation. To obtain more exact regression formulae, wider age range studies are recommended. Copyright © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  5. Association study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals

    DEFF Research Database (Denmark)

    Soerensen, Mette; Nygaard, Marianne; Dato, Serena

    2015-01-01

    -old Danes (age 92-93) with 4 phenotypes known to predict their survival: cognitive function, hand grip strength, activity of daily living (ADL), and self-rated health. Based on previous studies in humans and foxo animal models, we also explore self-reported diabetes, cancer, cardiovascular disease......FOXO3A variation has repeatedly been reported to associate with human longevity, yet only few studies have investigated whether FOXO3A variation also associates with aging-related traits. Here, we investigate the association of 15 FOXO3A tagging single nucleotide polymorphisms (SNPs) in 1088 oldest...... borderline significance (P = 0.054), while ADL did not (P = 0.396). Although the single-SNP associations did not formally replicate in another study population of oldest-old Danes (n = 1279, age 94-100), the estimates were of similar direction of effect as observed in the Discovery sample. A pooled analysis...

  6. Work after age 65: A prospective study of Australian men and women.

    Science.gov (United States)

    Majeed, Tazeen; Forder, Peta M; Tavener, Meredith; Vo, Kha; Byles, Julie

    2017-06-01

    This study describes hours in paid work for Australian men and women aged over 65, focusing on associations between work and education. Data were analysed separately for men and women, from baseline and first follow-up surveys of the 45 and Up Study. Generalised estimating equation models were used to identify associations between work, education and other factors over time. The odds of doing paid work increased with higher education level and decreased with time, age, poorer physical function and having health conditions (high blood pressure, diabetes, stroke and breast cancer). Un-partnered women were more likely to work in later life than partnered women. This study quantifies the importance of education and health factors in determining continued participation of Australian men and women in paid work in later life. These factors need to be considered for policies aiming to increase workforce participation beyond 65 years of age. © 2017 AJA Inc.

  7. Aging in Saudi Arabia: An Exploratory Study of Contemporary Older Persons' Views About Daily Life, Health, and the Experience of Aging.

    Science.gov (United States)

    Karlin, Nancy J; Weil, Joyce; Felmban, Wejdan

    2016-01-01

    Objective: This exploratory study sought to measure current self-reported experiences of older Saudi adults. Method: Self-reported aging perceptions and demographic data from semistructured questions were obtained from 52 community-dwelling older Saudi adults aged 50 or older. A thematic content analysis was completed around issues of family life/social support, daily/weekly activities, health and health programs, and older adults' own thoughts about aging and the experience and future of personal aging. Results: Several key themes emerged from the interviews. The majority of respondents in this preliminary study acknowledge a preference for family care. Formal programs in Saudi Arabia are attended with relative infrequency while older adults recognize family support as the preferred method of support. Older Saudi interviewees hold a positive view of aging, but physical functioning, varying financial resources, and other daily obligations are a concern for those in this study. Discussion: Data suggest as the Saudi population ages, more research is needed on the aging experience with particiular emphasis on issues relevant to older adults . Future research must work to clarify the aging experience as cultural context changes.

  8. Metabolic syndrome and its components in Polish women of childbearing age: a nationwide study

    Directory of Open Access Journals (Sweden)

    Dorota Szostak-Węgierek

    2017-07-01

    Full Text Available Abstract Background Abnormal body mass and related metabolic disorders may affect female reproductive health. The purpose of the study was to determine the prevalence of underweight, overweight, obesity, lipid and glucose metabolism disorders, hypertension, and metabolic syndrome, among Polish women of childbearing age. Methods One thousand five hundred eighty-eight non-pregnant Polish women of childbearing age (20–49 years who participated in the Multi-Centre National Population Health Examination Survey (WOBASZ II study in 2013–2014, were assigned to 3 age groups: 20–29 years (n = 403, 30–39 years (n = 600 and 40–49 years (n = 585. Measurements of weight, height, waist circumference, blood pressure, blood lipids, and blood glucose were taken. For statistical analysis, the Kruskal-Wallis, Chi-Square, and Cohran-Armitage tests were used. Results Of the participants, 4.3% were determined to be underweight, 25.2% were overweight, 15% were obese, and 53.1% had abdominal obesity. With age, the prevalence of both excessive body mass and abdominal obesity tended to increase, and that of underweight to decrease. Frequency of hypercholesterolemia and hypertriglyceridemia found in the whole group were 50% and 12.6% respectively, and also tended to rise with age. Low serum HDL-cholesterol (high density lipoprotein cholesterol levels were found in 15.1% of the participants. Prevalence of impaired fasting glucose in the whole group was 8.2% and tended to increase with age. Diabetes was found in 1.2% of the participants and its prevalence also tended to rise with age, at the borderline of significance. Frequency of arterial hypertension and metabolic syndrome in the whole group was 15.7% and 14.1% respectively and both tended to increase with age. Conclusions Overweight and obesity, especially of abdominal type, and the related metabolic abnormalities are common in Polish women of childbearing age. Their prevalence tends to increase with

  9. Metabolic syndrome and its components in Polish women of childbearing age: a nationwide study.

    Science.gov (United States)

    Szostak-Węgierek, Dorota; Waśkiewicz, Anna; Piotrowski, Walerian; Stepaniak, Urszula; Pająk, Andrzej; Kwaśniewska, Magdalena; Nadrowski, Paweł; Niklas, Arkadiusz; Puch-Walczak, Aleksandra; Drygas, Wojciech

    2017-07-13

    Abnormal body mass and related metabolic disorders may affect female reproductive health. The purpose of the study was to determine the prevalence of underweight, overweight, obesity, lipid and glucose metabolism disorders, hypertension, and metabolic syndrome, among Polish women of childbearing age. One thousand five hundred eighty-eight non-pregnant Polish women of childbearing age (20-49 years) who participated in the Multi-Centre National Population Health Examination Survey (WOBASZ II study) in 2013-2014, were assigned to 3 age groups: 20-29 years (n = 403), 30-39 years (n = 600) and 40-49 years (n = 585). Measurements of weight, height, waist circumference, blood pressure, blood lipids, and blood glucose were taken. For statistical analysis, the Kruskal-Wallis, Chi-Square, and Cohran-Armitage tests were used. Of the participants, 4.3% were determined to be underweight, 25.2% were overweight, 15% were obese, and 53.1% had abdominal obesity. With age, the prevalence of both excessive body mass and abdominal obesity tended to increase, and that of underweight to decrease. Frequency of hypercholesterolemia and hypertriglyceridemia found in the whole group were 50% and 12.6% respectively, and also tended to rise with age. Low serum HDL-cholesterol (high density lipoprotein cholesterol) levels were found in 15.1% of the participants. Prevalence of impaired fasting glucose in the whole group was 8.2% and tended to increase with age. Diabetes was found in 1.2% of the participants and its prevalence also tended to rise with age, at the borderline of significance. Frequency of arterial hypertension and metabolic syndrome in the whole group was 15.7% and 14.1% respectively and both tended to increase with age. Overweight and obesity, especially of abdominal type, and the related metabolic abnormalities are common in Polish women of childbearing age. Their prevalence tends to increase with age. Underweight is relatively common in the youngest age group.

  10. Effect of age on the diagnostic efficiency of HbA1c for diabetes in a Chinese middle-aged and elderly population: The Shanghai Changfeng Study.

    Science.gov (United States)

    Wu, Li; Lin, Huandong; Gao, Jian; Li, Xiaoming; Xia, Mingfeng; Wang, Dan; Aleteng, Qiqige; Ma, Hui; Pan, Baishen; Gao, Xin

    2017-01-01

    Glycated hemoglobin A1c (HbA1c) ≥6.5% (or 48mmol/mol) has been recommended as a new diagnostic criterion for diabetes; however, limited literature is available regarding the effect of age on the HbA1c for diagnosing diabetes and the causes for this age effect remain unknown. In this study, we investigated whether and why age affects the diagnostic efficiency of HbA1c for diabetes in a community-based Chinese population. In total, 4325 participants without previously known diabetes were enrolled in this study. Participants were stratified by age. Receiver operating characteristic curve (ROC) was plotted for each age group and the area under the curve (AUC) represented the diagnostic efficiency of HbA1c for diabetes defined by the plasma glucose criteria. The area under the ROC curve in each one-year age group was defined as AUCage. Multiple regression analyses were performed to identify factors inducing the association between age and AUCage based on the changes in the β and P values of age. The current threshold of HbA1c (≥6.5% or 48mmol/mol) showed low sensitivity (35.6%) and high specificity (98.9%) in diagnosing diabetes. ROC curve analyses showed that the diagnostic efficiency of HbA1c in the ≥75 years age group was significantly lower than that in the 45-54 years age group (AUC: 0.755 vs. 0.878; PHbA1c was negatively correlated with age (r = -0.557, P = 0.001). When adjusting the red blood cell (RBC) count in the multiple regression model, the negative association between age and AUCage disappeared, with the regression coefficient of age reversed to 0.001 and the P value increased to 0.856. The diagnostic efficiency of HbA1c for diabetes decreased with aging, and this age effect was induced by the decreasing RBC count with age. HbA1c is unsuitable for diagnosing diabetes in elderly individuals because of their physiologically decreased RBC count.

  11. Effect of age on the diagnostic efficiency of HbA1c for diabetes in a Chinese middle-aged and elderly population: The Shanghai Changfeng Study.

    Directory of Open Access Journals (Sweden)

    Li Wu

    Full Text Available Glycated hemoglobin A1c (HbA1c ≥6.5% (or 48mmol/mol has been recommended as a new diagnostic criterion for diabetes; however, limited literature is available regarding the effect of age on the HbA1c for diagnosing diabetes and the causes for this age effect remain unknown. In this study, we investigated whether and why age affects the diagnostic efficiency of HbA1c for diabetes in a community-based Chinese population.In total, 4325 participants without previously known diabetes were enrolled in this study. Participants were stratified by age. Receiver operating characteristic curve (ROC was plotted for each age group and the area under the curve (AUC represented the diagnostic efficiency of HbA1c for diabetes defined by the plasma glucose criteria. The area under the ROC curve in each one-year age group was defined as AUCage. Multiple regression analyses were performed to identify factors inducing the association between age and AUCage based on the changes in the β and P values of age.The current threshold of HbA1c (≥6.5% or 48mmol/mol showed low sensitivity (35.6% and high specificity (98.9% in diagnosing diabetes. ROC curve analyses showed that the diagnostic efficiency of HbA1c in the ≥75 years age group was significantly lower than that in the 45-54 years age group (AUC: 0.755 vs. 0.878; P<0.001. Pearson correlation analysis showed that the AUCage of HbA1c was negatively correlated with age (r = -0.557, P = 0.001. When adjusting the red blood cell (RBC count in the multiple regression model, the negative association between age and AUCage disappeared, with the regression coefficient of age reversed to 0.001 and the P value increased to 0.856.The diagnostic efficiency of HbA1c for diabetes decreased with aging, and this age effect was induced by the decreasing RBC count with age. HbA1c is unsuitable for diagnosing diabetes in elderly individuals because of their physiologically decreased RBC count.

  12. Changes in human gut flora with age: an Indian familial study.

    Science.gov (United States)

    Marathe, Nachiket; Shetty, Sudarshan; Lanjekar, Vikram; Ranade, Dilip; Shouche, Yogesh

    2012-09-26

    The gut micro flora plays vital role in health status of the host. The majority of microbes residing in the gut have a profound influence on human physiology and nutrition. Different human ethnic groups vary in genetic makeup as well as the environmental conditions they live in. The gut flora changes with genetic makeup and environmental factors and hence it is necessary to understand the composition of gut flora of different ethnic groups. Indian population is different in physiology from western population (YY paradox) and thus the gut flora in Indian population is likely to differ from the extensively studied gut flora in western population. In this study we have investigated the gut flora of two Indian families, each with three individuals belonging to successive generations and living under the same roof. Denaturation gradient gel electrophoresis analysis showed age-dependant variation in gut microflora amongst the individuals within a family. Different bacterial genera were dominant in the individual of varying age in clone library analysis. Obligate anaerobes isolated from individuals within a family showed age related differences in isolation pattern, with 27% (6 out of 22) of the isolates being potential novel species based on 16S rRNA gene sequence. In qPCR a consistent decrease in Firmicutes number and increase in Bacteroidetes number with increasing age was observed in our subjects, this pattern of change in Firmicutes / Bacteroidetes ratio with age is different than previously reported in European population. There is change in gut flora with age amongst the individuals within a family. The isolation of high percent of novel bacterial species and the pattern of change in Firmicutes /Bacteroidetes ratio with age suggests that the composition of gut flora in Indian individuals may be different than the western population. Thus, further extensive study is needed to define the gut flora in Indian population.

  13. Age matters. A study on motivation, flow and self-esteem in competing athletes.

    OpenAIRE

    Fossmo, Toril

    2006-01-01

    The present study tested whether there were any differences between athletes varying in age, or practising different sports at different levels, on the variables motivation, flow, self-esteem and personality. Of the 145 athletes that participated in the study, there were 85 males and 59 females (one missing) ranging from 18 to 40 years of age (M = 21.34, SD = 3.89). The athletes were grouped as team sport athletes (n = 74) and individual sport athletes (n = 71) in order to determine if th...

  14. A study of aging effects of barrel Time-Of-Flight system in the BESIII experiment

    Science.gov (United States)

    Liu, Huan-Huan; Sun, Sheng-Sen; Fang, Shuang-Shi; Wu, Zhi; Dai, Hong-Liang; Heng, Yue-Kun; Zhou, Ming; Deng, Zi-Yan; Liu, Huai-Min

    2018-02-01

    The Time-Of-Flight system consisting of plastic scintillation counters plays an important role for particle identification in the BESIII experiment at the BEPCII double ring e+e- collider. Degradation of the detection efficiency of the barrel TOF system has been observed since the start of physical data taking and this effect has triggered intensive and systematic studies about aging effects of the detector. The aging rates of the attenuation lengths and relative gains are obtained based on the data acquired in past several years. This study is essential for ensuring an extended operation of the barrel TOF system in optimal conditions.

  15. A Study of the Effect of Age of Onset of Treatment on the Observed Development of Down's Syndrome Babies.

    Science.gov (United States)

    Sanz, M. T.; Menendez, J.

    1996-01-01

    Studied how early treatment affected the development of a sample of 30 Down syndrome babies incorporated into the study at different ages. Found that development quotients descended significantly at 18 months of age as the period in treatment shortened. (AJH)

  16. Body and self: a phenomenological study on the ageing body and identity.

    Science.gov (United States)

    Bullington, J

    2006-06-01

    The aim of the study was to investigate how older people (60+) experience the ageing body and how these experiences affect aged peoples' sense of identity. Explorative, open ended, interviews were conducted with 13 respondents between the ages of 63 and 82, recruited from a retired peoples' organisation, Church organisations, and from the working population. The qualitative data was analysed with a phenomenological method, the so called EPP method, the empirical phenomenological psychological method. The results showed that generally the experience of the ageing body has to do with a changed life world, reactions to this change in terms of body and self, and finding ways to feel at home in this changed situation. Results are presented as three typologies, reflecting the different ways in which the respondents described this general experience: existential awakening, making it good enough, and new possibilities. The results give support to the research that points out the importance of activity for the self esteem of the elderly. According to this study, however, the meaning of "activity" can vary and can have different sources of motivation. Respondents in only one typology expressed frustration over limitations of the ageing body. Respondents exhibited entirely different ways of relating to the fact that death was approaching, which raises questions about how the elderly experience this impending horizon. Finally, the gender differences in this small study were quite clear: all the male respondents belonged to the typology "New possibilities", raising questions about gender aspects concerning the meaning of freedom, appearance, activity, and self esteem.

  17. Age as a Risk Factor for Burnout Syndrome in Nursing Professionals: A Meta-Analytic Study.

    Science.gov (United States)

    Gómez-Urquiza, José L; Vargas, Cristina; De la Fuente, Emilia I; Fernández-Castillo, Rafael; Cañadas-De la Fuente, Guillermo A

    2017-04-01

    Although past research has highlighted the possibility of a direct relationship between the age of nursing professionals and burnout syndrome, results have been far from conclusive. The aim of this study was to conduct a wider analysis of the influence of age on the three dimensions of burnout syndrome (emotional exhaustion, depersonalization, and personal accomplishment) in nurses. We performed a meta-analysis of 51 publications extracted from health sciences and psychology databases that fulfilled the inclusion criteria. There were 47 reports of information on emotional exhaustion in 50 samples, 39 reports on depersonalization for 42 samples, and 31 reports on personal accomplishment in 34 samples. The mean effect sizes indicated that younger age was a significant factor in the emotional exhaustion and depersonalization of nurses, although it was somewhat less influential in the dimension of personal accomplishment. Because of heterogeneity in the effect sizes, moderating variables that might explain the association between age and burnout were also analyzed. Gender, marital status, and study characteristics moderated the relationship between age and burnout and may be crucial for the identification of high-risk groups. More research is needed on other variables for which there were only a small number of studies. Identification of burnout risk factors will facilitate establishment of burnout prevention programs for nurses. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years

    Energy Technology Data Exchange (ETDEWEB)

    Gracien, Rene-Maxime; Nuernberger, Lucas; Hof, Stephanie-Michelle; Reitz, Sarah C.; Hilker-Roggendorf, Ruediger; Baudrexel, Simon [Goethe University, Department of Neurology, Frankfurt/Main (Germany); Goethe University, Brain Imaging Center, Frankfurt/Main (Germany); Hok, Pavel [Goethe University, Department of Neurology, Frankfurt/Main (Germany); Goethe University, Brain Imaging Center, Frankfurt/Main (Germany); Palacky University, Department of Neurology, Olomouc (Czech Republic); Rueb, Udo [Goethe University, Dr. Senckenberg Chronomedical Institute, Frankfurt/Main (Germany); Steinmetz, Helmuth [Goethe University, Department of Neurology, Frankfurt/Main (Germany); Klein, Johannes C. [Goethe University, Department of Neurology, Frankfurt/Main (Germany); Goethe University, Brain Imaging Center, Frankfurt/Main (Germany); University of Oxford, Nuffield Department of Clinical Neurosciences, Oxford (United Kingdom); Deichmann, Ralf [Goethe University, Brain Imaging Center, Frankfurt/Main (Germany)

    2017-04-15

    T1 relaxometry is a promising tool for the assessment of microstructural changes during brain ageing. Previous cross-sectional studies demonstrated increasing T1 values in white and decreasing T1 values in grey matter over the lifetime. However, these findings have not yet been confirmed on the basis of a longitudinal study. In this longitudinal study over 7 years, T1 relaxometry was used to investigate the dynamics of age-related microstructural changes in older healthy subjects. T1 mapping was performed in 17 healthy subjects (range 51-77 years) at baseline and after 7 years. Advanced cortical and white matter segmentation was used to determine mean T1 values in the cortex and white matter. The analysis revealed a decrease of mean cortical T1 values over 7 years, the rate of T1 reduction being more prominent in subjects with higher age. T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. In contrast, mean white matter T1 values remained stable. T1 mapping is shown to be sensitive to age-related microstructural changes in healthy ageing subjects in a longitudinal setting. Data of a cohort in late adulthood and the senescence period demonstrate a decrease of cortical T1 values over 7 years, most likely reflecting decreasing water content and increased iron concentrations. (orig.)

  19. Is midlife occupational physical activity related to disability in old age? The SNAC-Kungsholmen study.

    Directory of Open Access Journals (Sweden)

    Elisabeth Rydwik

    Full Text Available OBJECTIVES: Leisure-time physical activity (PA has been established to be related to more years lived without disability. However, less is known about the relationship between occupational PA and disability in old age. The aim of the study was 1 to investigate whether midlife occupational PA is related to late-life disability, and 2 to test the hypothesis that the association differs according to the occupational categories of blue and white collar work. METHODS: The study population was derived from the Swedish National Study on Aging and Care, and consisted of a random sample of 1804 subjects aged 72 and above. The association of occupational PA during the longest held occupation with disability in old age was determined using logistic regression. RESULTS: There was no significant relationship between occupational PA and disability in personal or instrumental activities of daily living (ADL after controlling for demographic and health-related factors. However, in stratified analyses moderate levels of occupational PA was associated with a lower odds ratio of dependency in personal ADL amongst white collar workers, compared to low level of occupational PA (OR = 0.34 95% C1 0.12-0.98. CONCLUSIONS: Moderate levels of midlife occupational PA were associated with a decreased risk of personal ADL disability in old age among white collar workers, but not among blue collar workers. Our results highlight the importance of encouraging white collar workers to engage in physical activity during or outside work hours.

  20. Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years

    International Nuclear Information System (INIS)

    Gracien, Rene-Maxime; Nuernberger, Lucas; Hof, Stephanie-Michelle; Reitz, Sarah C.; Hilker-Roggendorf, Ruediger; Baudrexel, Simon; Hok, Pavel; Rueb, Udo; Steinmetz, Helmuth; Klein, Johannes C.; Deichmann, Ralf

    2017-01-01

    T1 relaxometry is a promising tool for the assessment of microstructural changes during brain ageing. Previous cross-sectional studies demonstrated increasing T1 values in white and decreasing T1 values in grey matter over the lifetime. However, these findings have not yet been confirmed on the basis of a longitudinal study. In this longitudinal study over 7 years, T1 relaxometry was used to investigate the dynamics of age-related microstructural changes in older healthy subjects. T1 mapping was performed in 17 healthy subjects (range 51-77 years) at baseline and after 7 years. Advanced cortical and white matter segmentation was used to determine mean T1 values in the cortex and white matter. The analysis revealed a decrease of mean cortical T1 values over 7 years, the rate of T1 reduction being more prominent in subjects with higher age. T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. In contrast, mean white matter T1 values remained stable. T1 mapping is shown to be sensitive to age-related microstructural changes in healthy ageing subjects in a longitudinal setting. Data of a cohort in late adulthood and the senescence period demonstrate a decrease of cortical T1 values over 7 years, most likely reflecting decreasing water content and increased iron concentrations. (orig.)

  1. Age Adjusted D-Dimer for exclusion of Pulmonary Embolism: a retrospective cohort study.

    LENUS (Irish Health Repository)

    Monks, D

    2017-08-01

    D-Dimer (DD) will increase with age and recent studies have shown the upper limit of normal can be raised in those who are low risk and over 50. We studied age adjusted D-dimer (AADD) levels to assess whether pulmonary embolism (PE) could be safely excluded. This study analysed the Emergency Department (ED) Computed Tomographic Pulmonary Angiography (CTPA) requests. There were 756 requests. The parameters studied were; age, DD value, calculated AADD, CT result and Simplified Geneva Score (SGS). The primary outcome was the diagnostic performance of AADD. One hundred and eighty-five patients were included in the final cohort. Twenty-one patients had a negative DD after age adjustment. Of these one had a PE, corresponding to a failure rate of 4.76% (1 in 22). The sensitivity of AADD was 0.96 (95% CI 0.76 to 0.99) and its specificity was 0.12 (95% CI 0.08- 0.19). AADD demonstrated a reduction in false positives with one false negative, giving rise to a failure rate higher than that of other larger studies. Further study is indicated to accurately define the diagnostic characteristics for the Irish context.

  2. Lessons from the Bone Chapter of the Malaysian Aging Men Study

    Directory of Open Access Journals (Sweden)

    Kok-Yong Chin

    2016-05-01

    Full Text Available Male osteoporosis in Malaysia is a largely neglected problem. Therefore, a bone health study in men using quantitative ultrasonometry was launched as part of the Malaysian Aging Men Study in 2009–2012. This review aimed to summarize the findings of the aforementioned bone health study. The study examined the bone health of Chinese and Malaysian men aged 20 years and above living in Kuala Lumpur using a quantitative ultrasound device. Participants answered a questionnaire on their demographic details and physical activity status. Body anthropometry of the participants was measured and their blood collected for biochemical analysis. Results showed that a significant proportion of the Malaysian Chinese and Malay men had suboptimal bone health indicated by calcaneal speed of sound and vitamin D status. Age-related decline of the calcaneal speed of sound in these men was gradual and biphasic without ethnic difference. Body anthropometry such as height, weight, body mass index, and body fat percentage contributed to the variation of the calcaneal speed of sound in Malaysian men. Age-related changes in testosterone, insulin-like growth factor 1, and thyroid stimulating hormone also influenced the calcaneal speed of sound in these men. This study serves as a reminder that male osteoporosis in Malaysia should be an issue of concern. It is also a basis for a more comprehensive study on bone health in men in the future.

  3. Lessons from the Bone Chapter of the Malaysian Aging Men Study.

    Science.gov (United States)

    Chin, Kok-Yong; Wan Ngah, Wan Zurinah; Ima-Nirwana, Soelaiman

    2016-05-25

    Male osteoporosis in Malaysia is a largely neglected problem. Therefore, a bone health study in men using quantitative ultrasonometry was launched as part of the Malaysian Aging Men Study in 2009-2012. This review aimed to summarize the findings of the aforementioned bone health study. The study examined the bone health of Chinese and Malaysian men aged 20 years and above living in Kuala Lumpur using a quantitative ultrasound device. Participants answered a questionnaire on their demographic details and physical activity status. Body anthropometry of the participants was measured and their blood collected for biochemical analysis. Results showed that a significant proportion of the Malaysian Chinese and Malay men had suboptimal bone health indicated by calcaneal speed of sound and vitamin D status. Age-related decline of the calcaneal speed of sound in these men was gradual and biphasic without ethnic difference. Body anthropometry such as height, weight, body mass index, and body fat percentage contributed to the variation of the calcaneal speed of sound in Malaysian men. Age-related changes in testosterone, insulin-like growth factor 1, and thyroid stimulating hormone also influenced the calcaneal speed of sound in these men. This study serves as a reminder that male osteoporosis in Malaysia should be an issue of concern. It is also a basis for a more comprehensive study on bone health in men in the future.

  4. Age-dependent impairment of auditory processing under spatially focused and divided attention: an electrophysiological study.

    Science.gov (United States)

    Wild-Wall, Nele; Falkenstein, Michael

    2010-01-01

    By using event-related potentials (ERPs) the present study examines if age-related differences in preparation and processing especially emerge during divided attention. Binaurally presented auditory cues called for focused (valid and invalid) or divided attention to one or both ears. Responses were required to subsequent monaurally presented valid targets (vowels), but had to be suppressed to non-target vowels or invalidly cued vowels. Middle-aged participants were more impaired under divided attention than young ones, likely due to an age-related decline in preparatory attention following cues as was reflected in a decreased CNV. Under divided attention, target processing was increased in the middle-aged, likely reflecting compensatory effort to fulfill task requirements in the difficult condition. Additionally, middle-aged participants processed invalidly cued stimuli more intensely as was reflected by stimulus ERPs. The results suggest an age-related impairment in attentional preparation after auditory cues especially under divided attention and latent difficulties to suppress irrelevant information.

  5. A study on some adrenal androgens and immunological parameters in aging men

    International Nuclear Information System (INIS)

    Mater, S.N.A.

    2002-01-01

    The objective of the study was to demonstrate a possible relationship between endocrinosescence; as represented by serum level of DHEA and its sulfated form DHEAS; and immunoesescence; represented by interleukin-6 (il-6) in aging males. eighty - two male volunteers were classified according to their age into four groups: group 1 ( 20-30 years old , N = 19), group II (>30 -50 year, N= 21), group III (>50-65 years, N=21) and group IV (>65 years, N = 21). there were significant reduction in the levels of DHEA and DHEAS with advance in age in men, and these reduction were somehow importantly and directly related to age-related functional decrements, especially when accompanied with elevated levels of IL-6, which show sudden increase in their levels with advance in age . conclusion: this reverse relation between DHEA and DHEAS from side and il-6 from another side may participate in the explanation of aging process and some diseases related to it due to functional decrements, as a results of over production of pro inflammatory cytokine (IL-6)

  6. Ageing differentially affects neural processing of different conflict types – an fMRI study

    Directory of Open Access Journals (Sweden)

    Margarethe eKorsch

    2014-04-01

    Full Text Available Interference control and conflict resolution is affected by ageing. There is increasing evidence that ageing does not compromise interference control in general but rather shows distinctive effects on different components of interference control. Different conflict types, (e.g. stimulus-stimulus (S-S or stimulus-response (S-R conflicts trigger different cognitive processes and thus activate different neural networks. In the present functional magnetic resonance imaging (fMRI study, we used a combined Flanker and Stimulus Response Conflict (SRC task to investigate the effect of ageing on S-S and S-R conflicts. Behavioral data analysis revealed larger SRC effects in elderly. fMRI Results show that both age groups recruited similar regions (caudate nucleus, cingulate gyrus and middle occipital gyrus during Flanker conflict processing. Furthermore, elderly show an additional activation pattern in parietal and frontal areas. In contrast, no common activation of both age groups was found in response to the SRC. These data suggest that ageing has distinctive effects on S-S and S-R conflicts.

  7. Ageing differentially affects neural processing of different conflict types-an fMRI study.

    Science.gov (United States)

    Korsch, Margarethe; Frühholz, Sascha; Herrmann, Manfred

    2014-01-01

    Interference control and conflict resolution is affected by ageing. There is increasing evidence that ageing does not compromise interference control in general but rather shows distinctive effects on different components of interference control. Different conflict types, [e.g., stimulus-stimulus (S-S) or stimulus-response (S-R) conflicts] trigger different cognitive processes and thus activate different neural networks. In the present functional magnetic resonance imaging (fMRI) study, we used a combined Flanker and Stimulus Response Conflict (SRC) task to investigate the effect of ageing on S-S and S-R conflicts. Behavioral data analysis revealed larger SRC effects in elderly. fMRI Results show that both age groups recruited similar regions [caudate nucleus, cingulate gyrus and middle occipital gyrus (MOG)] during Flanker conflict processing. Furthermore, elderly show an additional activation pattern in parietal and frontal areas. In contrast, no common activation of both age groups was found in response to the SRC. These data suggest that ageing has distinctive effects on S-S and S-R conflicts.

  8. Magnetic Properties Studies on Thermal Aged Fe-Cu Alloys for the Simulation of Radiation Damage

    Energy Technology Data Exchange (ETDEWEB)

    Lee, C. K.; Kishore, M.B.; Park, D. G. [KAERI, Daejeon (Korea, Republic of); Son, De Rac. [Hannam University, Daejeon (Korea, Republic of)

    2016-05-15

    We evaluated the changes in magnetic properties due to cold rolling and thermal ageing of a Fe-1%Cu model alloy in this study. Initially, the alloy was 10% cold rolled, and isothermally aged at 400 .deg. C for 1, 10, 100 and 1000 hr. The samples were prepared at various thermal aging conditions and all the conditions were interpreted. The hysteresis loops, Magnetic Barkhausen noise (BN). The change of magnetic properties can be interpreted in terms of the domain wall motion and dislocation dynamics associated with copper rich precipitates (CRPs).The results were interpreted in terms of ageing time dependence of the precipitates evolution such as the volume fraction and size distribution. In order to evaluate the radiation embrittlement of RPV steel, A Cold rolled Fe-Cu model Alloy was prepared, The prepared samples were thermally aged by annealing at 400 .deg. C for various times, the magnetic properties of the annealed samples were measured, The Barkhausen noise and BH Loop shows a considerable trend corresponding to the Ageing time. The magnetic properties were interpreted and correlated to the CRPs formed through annealing process.

  9. The Role of Energy Balance in Successful Aging Among Elderly Individuals: The Multinational MEDIS Study.

    Science.gov (United States)

    Tyrovolas, Stefanos; Haro, Josep Maria; Mariolis, Anargiros; Piscopo, Suzanne; Valacchi, Giuseppe; Makri, Kornilia; Zeimbekis, Akis; Tyrovola, Dimitra; Bountziouka, Vassiliki; Gotsis, Efthimios; Metallinos, George; Tur, Josep-Antoni; Matalas, Antonia; Lionis, Christos; Polychronopoulos, Evangelos; Panagiotakos, Demosthenes

    2015-12-01

    The determinants that promote living beyond life expectancy and successful aging still remain unknown. The aim of the present work was to evaluate the role of energy balance in successful aging, in a random sample of older adults living in the Mediterranean basin. During 2005 to 2011, 2,663 older (aged 65-100 years) adults from 21 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were voluntarily enrolled in the study. Dietary habits, energy intake, expenditure, and energy balance were derived throughout standard procedures. A successful aging index (range = 0-10) was used. After adjusting for several confounders, high energy intake (i.e., >1,700 kcal/day), b-coefficient [95% CI] = -0.21[-0.37, -0.05], as well as positive energy balance, b-coefficient [95% CI] = -0.21 [-0.37, -0.05], were inversely associated with successful aging. A diet with excessive energy intake and a positive energy balance seems to be associated with lower quality of life, as measured through successful aging. © The Author(s) 2015.

  10. Physiological Study on the Relation of Heart Rate Variability in Ageing and Thyroid Hormone Disorder

    Directory of Open Access Journals (Sweden)

    Elsayed A. M. Shokr

    2016-04-01

    Full Text Available The present study aimed to investigate whether cardiac autonomic dysfunction in aging human might be related to an underlying thyroid disturbance. ageing has been associated with hypothyroidism and cardiac autonomic dysfunction. On the basis of body mass index (BMI, 150 patients were grouped into three groups (n = 50 48 years ± 2, 55 years ± 2 and 63 years ± 2. Electrocardiogram was recorded using PowerLab system and the time and frequency domain measures of heart rate variability (HRV were calculated. Fasting blood samples were drawn for measurement of serum thyroid stimulating hormone (TSH, total thyroxin (T4 and total triiodothyronine (T3 concentrations. The levels of TSH, T4 and T3 were not significantly different between the groups. The frequency domain HRV parameter reflecting parasympathetic tone (high-frequency normalized units, HFnu was significantly reduced in aging third groups group. The parameters which reflect sympathetic activation (Heart rate, low-frequency normalized units; LFnu and the LF/HF ratio were significantly increased in the aging group. HFnu was significantly and negatively correlated with age, whereas LFnu and LF/HF ratio were significantly and positively correlated with the above mentioned parameters. No significant relationships were noted between the HRV parameters and the levels of TSH or thyroid hormones. Cardiac autonomic dysfunction in aging human is not linked with underlying thyroid disturbance.

  11. Healthy Ageing in People with Intellectual Disabilities from Managers' Perspective: A Qualitative Study.

    Science.gov (United States)

    Johansson, Maria; Björne, Petra; Runesson, Ingrid; Ahlström, Gerd

    2017-08-18

    An increasing number of people with intellectual disability (ID) are reaching older ages today although they experience more health problems than the older population without ID. Leaders in intellectual disability services can greatly influence the conditions for a healthy ageing, and the aim of the present study was to explore healthy ageing in this group from the perspective of the leaders. Interviews with 20 leaders were subjected to qualitative content analysis. The findings gave rise to the overall theme ageing in dependence, which emerged from the following six categories: Supporting self-determination; Inaccessible activities after retirement; Signs of decline; Increased and specific needs for support and care; A non-question of gender; Aspects concerning the end of life and death. A prerequisite for healthy ageing in the case of people with ID is, according to the leaders, that they can live the life according to their preferences and make independent choices whilst at the same time receiving adequate support. With the shrinking of their social network after retirement, they become increasingly dependent on staff and leaders in the group home, who need to know what healthy ageing implies.

  12. Seroprevalence study of anti diphtheria antibodies in two age-groups of Romanian adults.

    Science.gov (United States)

    Dragomirescu, Cristiana Cerasella; Coldea, Ileana-Luminiţa; Ilie, Anamaria; Stănescu, Aurora; Ungureanu, Vasilica; Popa, Mircea Ioan

    2014-01-01

    Diphtheria represents a serious infectious disease with high epidemic potential. It is a vaccine preventable disease (a minimum vaccine coverage of 95% for children of 1 year and 90% in adults could prevent the disease). Diphtheria vaccination is included in the National Immunization Program (NIP). Complete vaccination for children consists in DTaP (diphtheria toxoid, tetanus toxoid and acellular pertussis vaccine) vaccine administration from the age of 2 months until 4 years and dT vaccine (tetanus toxoid and a reduced dose of diphtheria toxoid) at 14 years old. The aim of this paper was to highlight the protection against diphtheria of an age segment of the Romanian adult population (20 to 39 years old) using a seroprevalence study. The Romanian subjects were selected from two age groups: 20-29 years (n = 219) and 30-39 years (n = 229), representative for all counties of Romania. The commercial kit Anti-Diphtheria Toxoid ELISA (IgG) (EUROIMMUN) was used to detect the antibodies of IgG class against diphtheria toxoid in the sera obtained from our subjects. We detected a 56.6% rate of positive sera (> 0.1 IU/ml--protection level) for the 20-29 age group and 31.7% positivity for the 30-39 age group. These data show a low protection level against diphtheria of the Romanian adult population, which decreases with age. The serologic data on preventable vaccine diseases are useful in order to evaluate the success of the immunization programs.

  13. Study and understanding of the ageing mechanisms in lead-calcium alloys

    International Nuclear Information System (INIS)

    Rossi, F.

    2006-12-01

    The data available in the literature about ageing and over-ageing of lead-calcium alloys are often incomplete and inconsistent. It is undoubtedly due to the experimental difficulties encountered to observe the structure transformations which are numerous. As a result there is a certain confusion among the results of the different authors. Moreover, small variations in the process parameters and chemical composition may have some influence on the alloy behaviour. This work enabled us to obtain a set of TTT diagrams, more realistic and accurate than the ones available in the literature. Experimental techniques developed (particularly the preservation of the cold chain with is essential for the guaranty of the results repeatability), enabled particularly the study of the first transformations and better control the five stages of ageing and over-ageing. Our work have enabled to determine precisely the kinetics and the mechanisms of the transformations. This work constitutes a thorough analysis of the ageing and over-ageing of theses alloys. (author)

  14. Age-related contrast enhancement study of normal bone marrow in lumbar spinal MR imaging

    International Nuclear Information System (INIS)

    Kim, Young A; Ha, Doo Hoe

    1999-01-01

    The purpose of this study was to evaluate the degree of contrast enhancement of normal bone marrow in L-spine relating to aging and to determine the range of contrast enhancement in normal bone marrow. We analyzed a total of 120 patients (20 per decade) who had undergone lumbar spinal MRI and who ranged in age from the 2nd decade to more than the 7th. Bone marrow revealed no abnormal pathology. Sagittal T1-weighted spin echo sequences were obtained before and after gadolinium administration. For each sequence, a region of interest was drawn within the L1 vertebral body from the midsagittal slice. Signal intensity (SI) values of each sequence were ascertained and the percentage increase in SI was calculated. After contrast enhancement, lumbar MRI revealed no statistically significant in the percentage increase in SI of normal bone marrow in relation to aging. Most patients (99%) however showed an SI increase of between 10% and 49%. In only four, none of whom were aged over 40, was this increase above 50%. Lumbar MRI, revealed no statistically significant difference in percentage increase in SI in normal bone marrow relating to aging, but when the increase is above 50% in a patient aged over 40, bone marrow pathology should be further investigated

  15. The Role of Age and Gender in the Choice of Address Forms: A Sociolinguistic Study

    Directory of Open Access Journals (Sweden)

    Mahzad Mardiha

    2012-09-01

    Full Text Available The main objective of the present study is to investigate the impact of gender as well as age on the choice of forms of address in Persian. The hypothesis is that variation in the forms of address is related not only to gender of the interlocutors but also to the age of them. For this study, 30 university students- 15 males and 15 females- participated in this process that all of them were asked to fill out a questionnaire presented in the appendix. The results of the data analysis indicate that both men and women use address forms of formality (Šoma more frequently in addressing the older people from both genders that shows age is more significant than gender in determining the pronouns in address system of Persian.

  16. Organisational culture in residential aged care facilities: a cross-sectional observational study.

    Science.gov (United States)

    Etherton-Beer, Christopher; Venturato, Lorraine; Horner, Barbara

    2013-01-01

    Organisational culture is increasingly recognised as important for provision of high-quality long-term care. We undertook this study to measure organisational culture in residential aged care facilities in two Australian states. Cross-sectional observational study in 21 residential aged care facilities in Western Australia (n = 14) and Queensland (n = 7), Australia. Staff and next-of-kin of residents participated. Measurement comprised surveys of facility staff and residents' next-of-kin, and structured observation of indicators of care quality. Staff tended to rate organisational culture positively. Some qualitative feedback from staff emphasised negative perceptions of communication, leadership and teamwork. Staffing levels were perceived as a dominant challenge, threatening care quality. Direct observation revealed variability within and between facilities but suggested that most facilities (n = 12) were in the typical range, or were quality facilities (n = 8). There was scope to strengthen organisational culture in participating aged care facilities.

  17. Pilot studies on management of ageing of nuclear power plant components: Results of Phase 1

    International Nuclear Information System (INIS)

    1992-10-01

    To facilitate cooperation between the IAEA Member States and thus to enhance the safety and reliability of operating nuclear plants the IAEA has initiated pilot studies on the management of ageing of four representative plant components: the primary nozzle of the reactor pressure vessel, a motor operated valve, the concrete containment building and instrumentation and control cables. Phase 1 of the studies has been completed and its results are presented in this report. The report documents current understanding of ageing and methods for monitoring and mitigation of this ageing for the above components, identifies existing knowledge and technology gaps and defines follow-up work to deal with these gaps. Refs, figs and tabs

  18. Archaeointensity study of five Late Bronze Age fireplaces from Corent (Auvergne, France)

    OpenAIRE

    Hervé , Gwenaël; Chauvin , Annick; Milcent , Pierre-Yves; Tramon , Arthur

    2016-01-01

    International audience; Recent excavations at Corent (France) unearthed a vast Late Bronze Age settlement. The high density of fireplaces especially highlights it. The present study focuses on the archaeomagnetic study of five fireplaces. These ones were dated between 950 and 800 BCE by cross-dating of metallic and ceramic artefacts and by radiocarbon. The main objective of our study is to increase the archaeointensity database in Western Europe at the beginning of the first millennium BCE. T...

  19. Declines in swimming performance with age: a longitudinal study of Masters swimming champions

    Directory of Open Access Journals (Sweden)

    Rubin RT

    2013-03-01

    Full Text Available Robert T Rubin,1,2 Sonia Lin,3 Amy Curtis,4 Daniel Auerbach,5 Charlene Win6 1Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; 2UCLA Bruin Masters Swim Club, Los Angeles, CA, USA; 3Saint Louis University School of Medicine, Saint Louis, MO, USA; 4Indiana University School of Medicine, Indianapolis, IN, USA; 5University of California, Berkeley, CA, USA; 6Loyola Marymount University, Los Angeles, CA, USA Introduction: Because of its many participants and thorough records, competitive Masters swimming offers a rich data source for determining the rate of physical decline associated with aging in physically fit individuals. The decline in performance among national champion swimmers, both men and women and in short and long swims, is linear, at about 0.6% per year up to age 70–75, after which it accelerates in quadratic fashion. These conclusions are based primarily on cross-sectional studies, and little is known about individual performance declines with aging. Herein we present performance profiles of 19 male and 26 female national and international champion Masters swimmers, ages 25 to 96 years, participating in competitions for an average of 23 years. Methods and results: Swimmers’ longitudinal data were compared with the fastest times of world record holders across ages 35–100 years by two regression methods. Neither method proved to accurately model this data set: compared with the rates of decline estimated from the world record data, which represent the best recorded times at given ages, there was bias toward shallower rates of performance decline in the longitudinal data, likely owing to a practice effect in some swimmers as they began their Masters programs. In swimmers’ later years, once maximum performance had been achieved, individual profiles followed the decline represented in the world records, and a few swimmers became the world record holders. In some instances

  20. Ageing and Performance Studies of the Outer Tracker of the LHCb Detector

    International Nuclear Information System (INIS)

    Haas, T.

    2007-01-01

    The Outer Tracker is part of the LHCb tracking system. It uses drift chamber to measure the track of a particle. The straws have a length of 2.5m and a diameter of 4.9 mm. They are operated in proportional mode and should measure tracks with a precision of 200 μm per hit. In the first part, this thesis presents the results of a performance study for the Outer Tracker, focussing on spatial resolution and efficiency. The main part of this thesis deals with aging studies. Neither a test with 8 keV X-rays nor with highly ionising protons showed any change in the module behavior due to aging. The acceleration factors compared to LHCb were 8-180 (anode current >80 nA/cm) in the most irradiated areas. A charge of up to 3 C/cm was accumulated. Aging tests at anode currents below 15 nA/cm (acceleration factor 1) showed a significant gain drop for the already produced modules after only a few days (1-2 mC/cm) of irradiation. The aging depends on several parameters like gas flow velocity or gas mixture. There is no aging for anode currents >12 nA/cm. This aging is an effect of outgassing material used in the module. Tests showed that the outgassing is probably caused by the epoxy adhesive. Flushing and warming the modules reduce the aging significantly. As things are, the Outer Tracker modules can be operated in LHCb for several years. (orig.)

  1. Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study.

    Directory of Open Access Journals (Sweden)

    Marjon Stijntjes

    Full Text Available BACKGROUND: Decline in cognitive performance is a highly prevalent health condition in elderly. We studied whether offspring of nonagenarian siblings with a familial history of longevity, perform better on cognitive tests compared to their partners as controls. This is relevant since it could provide insights into determinants underlying decline in cognitive performance. METHODS: Cross-sectional analysis within the longitudinal cohort of the Leiden Longevity Study consisting of middle-aged offspring of nonagenarian siblings together with their partners (n = 500, mean age (SD 66.3 (6.1 and 65.7 (7.2 years, respectively as controls. Memory function, attention and processing speed were tested using the 15-Picture Learning Test, Stroop test and Digit Symbol Substitution Test. Data were analyzed with regression adjusted for age, gender, years of education and additionally for diabetes mellitus, cardiovascular diseases, alcohol use, smoking, inflammatory markers and apolipoprotein E genotype. Robust standard errors were used to account for familial relationships among the offspring. RESULTS: Cognitive performance was worse at higher calendar age (p<0.001, all except Stroop test part 1. The offspring performed better compared to their partners on trial 3 (p = 0.005, the immediate (p = 0.016 and delayed (p = 0.004 recall of the 15-Picture Learning Test as well as on the interference and combined interference score of the Stroop test (p = 0.014 and p = 0.036, respectively in the fully adjusted model. The difference between offspring and partners was estimated to be more than three years according to the observed difference in calendar age. CONCLUSIONS: Offspring of nonagenarian siblings with a familial history of longevity have better cognitive performance compared to the group of their partners of comparable age. This effect is independent of age-related diseases and known possible confounders. Possible explanations might be differences in subclinical

  2. Brain atrophy during aging. Quantitative studies with X-CT and NMR-CT

    Energy Technology Data Exchange (ETDEWEB)

    Matsuzawa, Taiju; Yamada, Kenji; Yamada, Susumu; Ono, Shuichi; Takeda, Shunpei; Hatazawa, Jun; Ito, Masatoshi; Kubota, Kazuo

    1985-12-01

    Age-related brain atrophy was investigated in thousands of persons with no neurologic disturbances using X-CT and NMR-CT. Brain atrophy was minimal in 34-35 years old in both sexes, increased exponentially to the increasing age after 34-35 years, and probably resulted in dementia, such as vascular or multi-infarct dementia. Brain atrophy was significantly greater in men than in women at all ages. Brain volumes were maximal in 34-35 years old in both sexes with minimal individual differences which increased proportionally to the increasing age. Remarkable individual differences in the extent of brain atrophy (20 - 30 %) existed among aged subjects. Progression of brain atrophy was closely related to loss of mental activities independently of their ages. Our longitudinal study has revealed that the most important factors promoting brain atrophy during aging was the decrease in the cerebral blood flow. We have classified brain atrophy into sulcal and cisternal enlargement type (type I), ventricular enlargement type (type II) and mixed type (type III) according to the clinical study using NMR-CT. Brain atrophy of type I progresses significantly in almost all of the geriatric disorders. This type of brain atrophy progresses significantly in heavy smokers and drinkers. Therefore this type of brain atrophy might be caused by the decline in the blood flow in anterior and middle cerebral arteries. Brain atrophy of type II was caused by the disturbance of cerebrospinal fluid circulation after cerebral bleeding and subarachnoid bleeding. Brain atrophy of type III was seen in vascular dementia or multi-infarct dementia which was caused by loss of brain matter after multiple infarction, and was seen also in dementia of Alzheimer type in which degeneration of nerve cells results in brain atrophy. NMR-CT can easily detect small infarction (lacunae) and edematous lesions resulting from ischemia and hypertensive encephalopathy. (J.P.N.).

  3. Prenatal famine, birthweight, reproductive performance and age at menopause: the Dutch hunger winter families study.

    Science.gov (United States)

    Yarde, F; Broekmans, F J M; van der Pal-de Bruin, K M; Schönbeck, Y; te Velde, E R; Stein, A D; Lumey, L H

    2013-12-01

    Is there an association between acute prenatal famine exposure or birthweight and subsequent reproductive performance and age at menopause? No association was found between intrauterine famine exposure and reproductive performance, but survival analysis showed that women exposed in utero were 24% more likely to experience menopause at any age. Associations between prenatal famine and subsequent reproductive performance have been examined previously with inconsistent results. Evidence for the effects of famine exposure on age at natural menopause is limited to one study of post-natal exposure. This cohort study included men and women born around the time of the Dutch famine of 1944-1945. The study participants (n = 1070) underwent standardized interviews on reproductive parameters at a mean age of 59 years. The participants were grouped as men and women with prenatal famine exposure (n = 407), their same-sex siblings (family controls, n = 319) or other men and women born before or after the famine period (time controls, n = 344). Associations of famine exposure with reproductive performance and menopause were analysed using logistic regression and survival analysis with competing risk, after controlling for family clustering. Gestational famine exposure was not associated with nulliparity, age at birth of first child, difficulties conceiving or pregnancy outcome (all P> 0.05) in men or women. At any given age, women were more likely to experience menopause after gestational exposure to famine (hazard ratio 1.24; 95% CI 1.03, 1.51). The association was not attenuated with an additional control for a woman's birthweight. In this study, there was no association between birthweight and age at menopause after adjustment for gestational famine exposure. Age at menopause was self-reported and assessed retrospectively. The study power to examine associations with specific gestational periods of famine exposure and reproductive function was limited. Our findings support

  4. Why older workers work beyond the retirement age: a qualitative study

    Directory of Open Access Journals (Sweden)

    Ranu Sewdas

    2017-08-01

    Full Text Available Abstract Background The aims of the present study were to: 1 gain insight into reasons for working beyond the statutory retirement age from older workers’ perspectives, and 2 explore how the domains of the research framework Study on Transitions in Employment, Ability and Motivation (STREAM can be applied to working beyond retirement age. Methods A qualitative research design included individual interviews (n = 15 and three focus groups (n = 18 participants conducted with older workers aged 65 years and older continuing in a paid job or self-employment. Interview participants were recruited from an existing STREAM cohort study. Focus group participants were recruited from companies and employment agencies. The data were subjected to thematic analysis. Results The most important motives for working beyond retirement age were maintaining daily routines and financial benefit. Good health and flexible work arrangements were mentioned as important preconditions. The themes emerging from the categorization of the motives and preconditions corresponded to the domains of health, work characteristics, skills and knowledge, and social and financial factors from the STREAM research framework. However, our analysis revealed one additional theme—purpose in life. Conclusion This study offers important new insights into the various preconditions and motives that influence working beyond retirement age. In addition, the five domains of the STREAM research framework, including the additional domain of ‘purpose in life’, seem to be applicable to working beyond retirement age. This knowledge contributes to the development of work-related interventions that enhance older workers’ motivation to prolong their working lives.

  5. Lateralization patterns of covert but not overt movements change with age: An EEG neurofeedback study.

    Science.gov (United States)

    Zich, Catharina; Debener, Stefan; De Vos, Maarten; Frerichs, Stella; Maurer, Stefanie; Kranczioch, Cornelia

    2015-08-01

    The mental practice of movements has been suggested as a promising add-on therapy to facilitate motor recovery after stroke. In the case of mentally practised movements, electroencephalogram (EEG) can be utilized to provide feedback about an otherwise covert act. The main target group for such an intervention are elderly patients, though research so far is largely focused on young populations (study therefore aimed to examine the influence of age on the neural correlates of covert movements (CMs) in a real-time EEG neurofeedback framework. CM-induced event-related desynchronization (ERD) was studied in young (mean age: 23.6 years) and elderly (mean age: 62.7 years) healthy adults. Participants performed covert and overt hand movements. CMs were based on kinesthetic motor imagery (MI) or quasi-movements (QM). Based on previous studies investigating QM in the mu frequency range (8-13Hz) QM were expected to result in more lateralized ERD% patterns and accordingly higher classification accuracies. Independent of CM strategy the elderly were characterized by a significantly reduced lateralization of ERD%, due to stronger ipsilateral ERD%, and in consequence, reduced classification accuracies. QM were generally perceived as more vivid, but no differences were evident between MI and QM in ERD% or classification accuracies. EEG feedback enhanced task-related activity independently of strategy and age. ERD% measures of overt and covert movements were strongly related in young adults, whereas in the elderly ERD% lateralization is dissociated. In summary, we did not find evidence in support of more pronounced ERD% lateralization patterns in QM. Our finding of a less lateralized activation pattern in the elderly is in accordance to previous research and with the idea that compensatory processes help to overcome neurodegenerative changes related to normal ageing. Importantly, it indicates that EEG neurofeedback studies should place more emphasis on the age of the potential end

  6. Assessment of effect of age, gender, and dentoalveolar changes on mandibular morphology: A digital panoramic study

    Directory of Open Access Journals (Sweden)

    V Sairam

    2018-01-01

    Full Text Available Introduction: With progressive development in the growth and function of the jaws, changes are observed in size as well as shape of the mandible, which vary on the basis of age, gender, and dental status. The objective of this study was to evaluate and assess the morphological changes of the mandible, with varying age, gender, and dental status, using panoramic radiographs. Materials and Methods: A retrospective study was conducted using digital panoramic radiographs taken by Kodak 8000c digital panoramic and cephalometric system on 150 patients, comprising fifty edentulous individuals (above 50 years of age, fifty old dentate individuals (above 50 years of age, and fifty young dentate individuals (below 25 years of age. All the mandibular measurements (gonial angle, ramus length, condylar length (CL, ramus notch depth, and cortical bone thickness were carried out using RadiAnt DICOM VIEWER 2.2.9 (32-bit software. The measurements were then subjected to paired t-test, Tukey's multiple post hoc procedures, and multiple linear regression analysis. Results: Descriptive statistics for all the parameters on the right and left sides of the mandible in both males and females were analyzed. A statistical significance of P < 0.05 was observed for all the variables except one variable (CL. Conclusion: In the present study, all the variables showed increased measurements in males except gonial angle, which was found to be wider in females, indicating that women tend to get affected by varying dental statuses than men. Hence, the parameters used in this study may act as good indicators for the assessment of the effect of age, gender, and dental status on mandibular morphology.

  7. Comparative study of age estimation using dentinal translucency by digital and conventional methods

    Science.gov (United States)

    Bommannavar, Sushma; Kulkarni, Meena

    2015-01-01

    Introduction: Estimating age using the dentition plays a significant role in identification of the individual in forensic cases. Teeth are one of the most durable and strongest structures in the human body. The morphology and arrangement of teeth vary from person-to-person and is unique to an individual as are the fingerprints. Therefore, the use of dentition is the method of choice in the identification of the unknown. Root dentin translucency is considered to be one of the best parameters for dental age estimation. Traditionally, root dentin translucency was measured using calipers. Recently, the use of custom built software programs have been proposed for the same. Objectives: The present study describes a method to measure root dentin translucency on sectioned teeth using a custom built software program Adobe Photoshop 7.0 version (Adobe system Inc, Mountain View California). Materials and Methods: A total of 50 single rooted teeth were sectioned longitudinally to derive a 0.25 mm uniform thickness and the root dentin translucency was measured using digital and caliper methods and compared. The Gustafson's morphohistologic approach is used in this study. Results: Correlation coefficients of translucency measurements to age were statistically significant for both the methods (P < 0.125) and linear regression equations derived from both methods revealed better ability of the digital method to assess age. Conclusion: The custom built software program used in the present study is commercially available and widely used image editing software. Furthermore, this method is easy to use and less time consuming. The measurements obtained using this method are more precise and thus help in more accurate age estimation. Considering these benefits, the present study recommends the use of digital method to assess translucency for age estimation. PMID:25709325

  8. The prevalence of age-related macular degeneration in Italy (PAMDI) study: report 1.

    Science.gov (United States)

    Piermarocchi, Stefano; Segato, Tatiana; Scopa, Pasquale; Masetto, Morena; Ceca, Stela; Cavarzeran, Fabiano; Peto, Tunde

    2011-06-01

    The present study aimed to estimate prevalence and risk factors associated with age-related macular degeneration (ARMD) in an Italian population and to analyze differences between urban and rural communities. We conducted a population-based cross-sectional study among elderly residents in Northeast Italy. Participants were divided into urban and rural groups based on whether they lived in the city of Padova or the villages of Teolo and Torreglia, respectively. Fundus photographs were graded according to the International Classification for Age-related Maculopathy. A total of 1162 randomly selected subjects aged 61 years or more were invited to participate in the study. We examined 885 subjects, and 845 were eligible for fundus photograph grading. ARMD was estimated to affect 62.7% of the whole population (drusen 63-124 μm = 48.3%; drusen ≥125 μm = 10.4%; advanced ARMD = 4.1%). Age was confirmed as a risk factor for drusen ≥125 μm and advanced ARMD (Odds Ratio [OR] = 1.47, 95% Confidence Interval [CI] 1.28-1.69 and OR = 1.62, 95% CI 1.28-2.05, respectively, for a 5-year increase in age). The rural group appeared to be at a higher risk of developing large drusen compared to the urban sample (OR = 1.61, 95% CI 1.01-2.63) when adjusting for age and gender. The results confirmed that ARMD affects a high percentage of the elderly population in Italy. This study does not support the hypothesis that living in a rural environment or belonging to a population of the Mediterranean basin may be protective against the intermediate stages of the disease.

  9. Physical activity in middle-aged women and hip fracture risk: the UFO study.

    Science.gov (United States)

    Englund, U; Nordström, P; Nilsson, J; Bucht, G; Björnstig, U; Hallmans, G; Svensson, O; Pettersson, U

    2011-02-01

    In a population-based case-control study, we demonstrate that middle-aged women who were active with walking or in different physical spare time activities were at lower risk of later sustaining a hip fracture compared to more sedentary women. In middle-aged women participating in the Umeå Fracture and Osteoporosis (UFO) study, we investigated whether physical activity is associated with a subsequent decreased risk of sustaining a hip fracture. The UFO study is a nested case-control study investigating associations between bone markers, lifestyle, and osteoporotic fractures. We identified 81 female hip fracture cases that had reported lifestyle data before they sustained their fracture. Each case was compared with two female controls who were identified from the same cohort and matched for age and week of reporting data, yielding a total cohort of 237 subjects. Mean age at baseline was 57.2 ± 5.0 years, and mean age at fracture was 65.4 ± 6.4 years. Conditional logistic regression analysis with adjustments for height, weight, smoking, and menopausal status showed that subjects who were regularly active with walking or had a moderate or high frequency of physical spare time activities (i.e. berry/mushroom picking and snow shovelling) were at reduced risk of sustaining a hip fracture (OR 0.14; 95% CI; 0.05-0.53 for walking and OR 0.19; 95% CI; 0.08-0.46, OR 0.17, 95% CI; 0.05-0.64 for moderate and high frequency of spare time activities, respectively) compared to more sedentary women. An active lifestyle in middle age seems to reduce the risk of future hip fracture. Possible mechanisms may include improved muscle strength, coordination, and balance resulting in a decreased risk of falling and perhaps also direct skeletal benefits.

  10. Normal morphology of sacroiliac joints in children: magnetic resonance studies related to age and sex

    International Nuclear Information System (INIS)

    Bollow, M.; Paris, S.; Mutze, S.; Hamm, B.; Braun, J.; Kannenberg, J.; Biedermann, T.; Schauer-Petrowskaja, C.

    1997-01-01

    Objective. To determine in a prospective study the normal MRI morphology of the sacroiliac joints (SIJs) in relation to age and sex during adolescence. Design and patients. A total of 98 children (63 boys, mean age 12.7±2.8 years; 35 girls, mean age 13.7±2.3 years), ranging in age from 8 to 17 years, with juvenile chronic arthritis (JCA) but without signs of sacroiliitis fulfilled the study prerequisites (no back pain and no pathologic changes of the SIJs on physical examination before MRI in a 1.5-year follow-up). An additional eight HLA-B27-negative boys and eight HLA-B27-negative girls without arthritis served as controls. The MRI protocol comprised a T1-weighted SE sequence, an opposed-phase T2*-weighted GE sequence, and a dynamic contrast-enhanced study in single-section technique. Results. Noncontrast MRI permitted differentiation of ''open'' from ossified segmental and lateral apophyses of the sacral wings, with a significant difference in age (P <0.05) between children with open and ossified apophyses. Ossification of the apophyses of the sacral wings was seen significantly earlier (P <0.05) in girls than in boys. Girls also had a significantly higher incidence of transitional lumbosacral vertebrae, pelvic asymmetries, and accessory joints. In the contrast-enhanced opposed-phase MRI study, normal cartilage of the SIJs showed no contrast enhancement whereas the joint capsule showed a moderate enhancement. Conclusion. There are significant age- and sex-related differences in the normal MRI morphology of juvenile SIJs. Our findings might serve as a standard of comparison for the evaluation of pathologic changes - in particular for the early identification of juvenile sacroiliitis. (orig.)

  11. Is the age at menopause a cause of sexual dysfunction? A Brazilian population-based study.

    Science.gov (United States)

    Lett, Caio; Valadares, Ana L R; Baccaro, Luiz F; Pedro, Adriana O; Filho, Jeffrey L; Lima, Marcelo; Costa-Paiva, Lucia

    2018-01-01

    The aim of the study was to evaluate the association between age at menopause and sexual dysfunction and the components of sexual function in postmenopausal women. In this cross-sectional population-based study, data of 540 women aged 45 to 60 years regarding the age they were when they achieved menopause and its association with sexual dysfunction (evaluated using the Short Personal Experiences Questionnaire) were obtained through interviews. We assessed the data for associations between age at menopause and sexual dysfunction and demographic, behavioral, and clinical characteristics. Age at menopause was not associated with sexual dysfunction. Arousal (dysfunction) was the only component of sexual function that was associated with premature ovarian insufficiency (POI) and early menopause (P = 0.01). It was reported by 64.2% of women with POI (women 45 years, respectively (P = 0.04). In women with POI or early menopause, Poisson regression analysis showed that having a partner with sexual problems (prevalence ratio [PR] = 6.6; 95% CI: 3.3-13,2; P POI. The major factors affecting this association were having a partner with sexual problems, dyspareunia, and no satisfaction with the partner as a lover. These findings highlight the importance of evaluating partner problems and improving lubrication in these groups of women.

  12. Study of Adolescents Perceived Parenting Styles Based on their Gender and Age

    Directory of Open Access Journals (Sweden)

    صادق تقی لو

    2017-12-01

    Full Text Available Parenting styles play a major role in determining the life styles of adolescents and that is why they share a special significance. The present study was done with the aim to investigate adolescents’ perceived parenting styles based on their gender and age. The study was conducted by a post-event method and with a sample size of 623 subjects (311 female and 312 male, who were selected by the multistage sampling method. Data were analyzed, after being collected by the Baumrind Parenting Styles Questionnaire, using multivariate analysis of variance. The results indicated that the main effects of gender and age are significant at 0.01 level. Parents’ interaction with boys is more authoritarian and with girls more authoritative; also compared with adolescents less than 17 years, they interact with adolescents 17 years old more permissively. The interaction effects of gender and age were significant at 0.05 level only in the permissive parenting style. This means that unlike the girls, parents use more and more the permissive parenting style along with increasing age of adolescent teenage boys. It was concluded that the interaction patterns of parents with children are not fixed and these patterns vary according to gender and age of the children.

  13. Being given a cancer diagnosis in old age: a phenomenological study

    DEFF Research Database (Denmark)

    Esbensen, Bente Appel; Swane, Christine E; Hallberg, Ingalill Rahm

    2008-01-01

    Objectives: The aim of the study was to illuminate the lived experience of being given a cancer diagnosis in old age. Background: Little research has been done on the experience of elderly people developing cancer and the impact of the illness on their lives. Such knowledge is needed to support e...... in clinical practice, to identify the specific meaning the turning point has for an elderly person with cancer, and to understand the particular approach he or she uses to handle the awareness of being old. (C) 2006 Elsevier Ltd. All rights reserved Udgivelsesdato: 2008/3......Objectives: The aim of the study was to illuminate the lived experience of being given a cancer diagnosis in old age. Background: Little research has been done on the experience of elderly people developing cancer and the impact of the illness on their lives. Such knowledge is needed to support...... elderly people in dealing with issues arising after cancer is diagnosed. Design: A descriptive phenomenological method was used to investigate the phenomenon "the lived experience of being given a cancer diagnosis in old age". Participants: In total, 16 persons (aged 65+, mean age 76, range 68...

  14. Genetic Complexity of Episodic Memory: A Twin Approach to Studies of Aging

    Science.gov (United States)

    Kremen, William S.; Spoon, Kelly M.; Jacobson, Kristen C.; Vasilopoulos, Terrie; McCaffery, Jeanne M.; Panizzon, Matthew S.; Franz, Carol E.; Vuoksimaa, Eero; Xian, Hong; Rana, Brinda K.; Toomey, Rosemary; McKenzie, Ruth; Lyons, Michael J.

    2016-01-01

    Episodic memory change is a central issue in cognitive aging, and understanding that process will require elucidation of its genetic underpinnings. A key limiting factor in genetically informed research on memory has been lack of attention to genetic and phenotypic complexity, as if “memory is memory” and all well-validated assessments are essentially equivalent. Here we applied multivariate twin models to data from late-middle-aged participants in the Vietnam Era Twin Study of Aging to examine the genetic architecture of 6 measures from 3 standard neuropsychological tests: the California Verbal Learning Test-2, and Wechsler Memory Scale-III Logical Memory (LM) and Visual Reproductions (VR). An advantage of the twin method is that it can estimate the extent to which latent genetic influences are shared or independent across different measures before knowing which specific genes are involved. The best-fitting model was a higher order common pathways model with a heritable higher order general episodic memory factor and three test-specific subfactors. More importantly, substantial genetic variance was accounted for by genetic influences that were specific to the latent LM and VR subfactors (28% and 30%, respectively) and independent of the general factor. Such unique genetic influences could partially account for replication failures. Moreover, if different genes influence different memory phenotypes, they could well have different age-related trajectories. This approach represents an important step toward providing critical information for all types of genetically informative studies of aging and memory. PMID:24956007

  15. Study about the effects of different fitness sports on cognitive function and emotion of the aged.

    Science.gov (United States)

    Zhang, Xinan; Ni, Xiaomei; Chen, Peijie

    2014-12-01

    The aim of the study was to explore the effects of different fitness sports on cognitive function and emotion of the aged people. A total of 150 subjects aged between 60 and 70 were recruited from Shenyang Aged University and elderly activity center. All subjects reported no fitness before this study. The aged subjects were divided into five groups, included swimming group (A group), running group (B group), square dancing group (C group), Tai Chi group (D group) and control group (E group) with 30 people in each group. Subjects in each group received exercise intervention continued for 18 months. At baseline, 6, 12 and 18 months after intervention, the P300 test, SECF, HAMD and HAMA scale evaluations were performed. Compared to E group, the P2, N2 and P3 latency and response time in the D group after intervention for 6 months, and in the A-C groups after intervention for 12 months were significantly prolonged. The anxiety symptom and depression levels in the A-D groups after intervention for 12 months were significantly decreased when compared to E group (P effect of exercise intervention for Tai Chi group was the most significant. Different fitness sports have marked beneficial effect on cognitive function and emotion of the aged people, especially the Tai Chi exercise.

  16. Glomerulogenesis: Can it predict the gestational age? A study of 176 fetuses

    Directory of Open Access Journals (Sweden)

    Panduranga Chikkannaiah

    2012-01-01

    Full Text Available Background: Accurate assessment of gestational age of fetuses is essential from both clinical and medico-legal point of view. Crown-rump length, crown-heel length, foot length, and the weight of the fetus are the commonly used parameters for fetal age assessment. However, this estimate often lacks accuracy and sometimes is necessary to combine other data. An analysis of the embryological development of nephrons in the kidney can assist in this determination. Objective : To correlate the gestational age with the histological study of sequential development of nephrons in fetal kidney. Materials and Methods: This study included 176 fetuses delivered between June 2009 and June 2011 and aged from 12 to 40 weeks. The number of glomerular generations counted in hematoxylin and eosin-stained microscopic sections of the kidneys were correlated with the reported period of gestation based on obstetrical methods. Regression analysis was used to determine the statistical significance of the correlation. Results: A high degree of statistically significant correlation was observed between the period of gestation and the number of glomerular generations (P value < 0.0001. Conclusion: The histological assessment of the number of glomerular generations in kidney can be used as a reliable method of estimating fetal age.

  17. Age at Menarche and Time Spent in Education: A Mendelian Randomization Study.

    Science.gov (United States)

    Gill, D; Del Greco M, F; Rawson, T M; Sivakumaran, P; Brown, A; Sheehan, N A; Minelli, C

    2017-09-01

    Menarche signifies the primary event in female puberty and is associated with changes in self-identity. It is not clear whether earlier puberty causes girls to spend less time in education. Observational studies on this topic are likely to be affected by confounding environmental factors. The Mendelian randomization (MR) approach addresses these issues by using genetic variants (such as single nucleotide polymorphisms, SNPs) as proxies for the risk factor of interest. We use this technique to explore whether there is a causal effect of age at menarche on time spent in education. Instruments and SNP-age at menarche estimates are identified from a Genome Wide Association Study (GWAS) meta-analysis of 182,416 women of European descent. The effects of instruments on time spent in education are estimated using a GWAS meta-analysis of 118,443 women performed by the Social Science Genetic Association Consortium (SSGAC). In our main analysis, we demonstrate a small but statistically significant causal effect of age at menarche on time spent in education: a 1 year increase in age at menarche is associated with 0.14 years (53 days) increase in time spent in education (95% CI 0.10-0.21 years, p = 3.5 × 10 -8 ). The causal effect is confirmed in sensitivity analyses. In identifying this positive causal effect of age at menarche on time spent in education, we offer further insight into the social effects of puberty in girls.

  18. Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: A 1H-MRS study

    International Nuclear Information System (INIS)

    Reyngoudt, Harmen; Claeys, Tom; Vlerick, Leslie; Verleden, Stijn; Acou, Marjan; Deblaere, Karel; De Deene, Yves; Audenaert, Kurt; Goethals, Ingeborg; Achten, Eric

    2012-01-01

    Objective: To study age-related metabolic changes in N-acetylaspartate (NAA), total creatine (tCr), choline (Cho) and myo-inositol (Ins). Materials and methods: Proton magnetic resonance spectroscopy ( 1 H-MRS) was performed in the posterior cingulate cortex (PCC) and the left hippocampus (HC) of 90 healthy subjects (42 women and 48 men aged 18–76 years, mean ± SD, 48.4 ± 16.8 years). Both metabolite ratios and absolute metabolite concentrations were evaluated. Analysis of covariance (ANCOVA) and linear regression were used for statistical analysis. Results: Metabolite ratios Ins/tCr and Ins/H 2 O were found significantly increased with age in the PCC (P 2 O was only observed in the PCC (P 1 H-MRS results in these specific brain regions can be important to differentiate normal ageing from age-related pathologies such as mild cognitive impairment (MCI) and Alzheimer's disease.

  19. Age adjustment in ecological studies: using a study on arsenic ingestion and bladder cancer as an example.

    Science.gov (United States)

    Guo, How-Ran

    2011-10-20

    Despite its limitations, ecological study design is widely applied in epidemiology. In most cases, adjustment for age is necessary, but different methods may lead to different conclusions. To compare three methods of age adjustment, a study on the associations between arsenic in drinking water and incidence of bladder cancer in 243 townships in Taiwan was used as an example. A total of 3068 cases of bladder cancer, including 2276 men and 792 women, were identified during a ten-year study period in the study townships. Three methods were applied to analyze the same data set on the ten-year study period. The first (Direct Method) applied direct standardization to obtain standardized incidence rate and then used it as the dependent variable in the regression analysis. The second (Indirect Method) applied indirect standardization to obtain standardized incidence ratio and then used it as the dependent variable in the regression analysis instead. The third (Variable Method) used proportions of residents in different age groups as a part of the independent variables in the multiple regression models. All three methods showed a statistically significant positive association between arsenic exposure above 0.64 mg/L and incidence of bladder cancer in men and women, but different results were observed for the other exposure categories. In addition, the risk estimates obtained by different methods for the same exposure category were all different. Using an empirical example, the current study confirmed the argument made by other researchers previously that whereas the three different methods of age adjustment may lead to different conclusions, only the third approach can obtain unbiased estimates of the risks. The third method can also generate estimates of the risk associated with each age group, but the other two are unable to evaluate the effects of age directly.

  20. Culture and diet among Chinese American children aged 9–13 years: A qualitative study

    Science.gov (United States)

    This study examined Chinese American children's behaviors, food preferences, and cultural influences on their diet. Qualitative individual interviews were conducted with twenty-five Chinese American children aged 9-13 years in community centers and Chinese schools in Houston, TX using constructs fro...

  1. Cycle aging studies of lithium nickel manganese cobalt oxide-based batteries using electrochemical impedance spectroscopy

    NARCIS (Netherlands)

    Maheshwari, Arpit; Heck, Michael; Santarelli, Massimo

    2018-01-01

    The cycle aging of a commercial 18650 lithium-ion battery with graphite anode and lithium nickel manganese cobalt (NMC) oxide-based cathode at defined operating conditions is studied by regular electrochemical characterization, electrochemical impedance spectroscopy (EIS) and post-mortem analysis.

  2. Cataract surgery and the risk of aging macula disorder: The Rotterdam study

    NARCIS (Netherlands)

    L. Ho (Lintje); S. Boekhoorn (Sharmila); A. Liana (Alin); P. Tikka-Kleemola (Päivi); A.G. Uitterlinden (André); A. Hofman (Albert); P.T.V.M. de Jong (Paulus); Th. Stijnen (Theo); J.R. Vingerling (Hans)

    2008-01-01

    textabstractPURPOSE. To investigate still-controversial associations between prior cataract surgery and aging macula disorder (AMD) in a general population. METHODS. Baseline lens status and risk of incident AMD (iAMD) were examined in participants of the prospective population-based Rotterdam Study

  3. Addressing the Myths and Realities of Age in a Russian Theatre Study.

    Science.gov (United States)

    Mikhailova, Anna

    1994-01-01

    Reports on an extensive study conducted with 10- to 12-year-old children in 3 Moscow schools to determine their aesthetic perceptions and comprehension of layers of metaphoric meanings in the Leningrad Theatre for Young Spectators' production of "Bambi." Shows that metaphoric comprehension decreases within this age group, countering the…

  4. Relative Age Effects in a Cognitive Task: A Case Study of Youth Chess

    Science.gov (United States)

    Helsen, Werner F.; Baker, Joseph; Schorer, Joerg; Steingröver, Christina; Wattie, Nick; Starkes, Janet L.

    2016-01-01

    The relative age effect (RAE) has been demonstrated in many youth and professional sports. In this study, we hypothesized that there would also be a RAE among youth chess players who are typically involved in a complex cognitive task without significant physical requirements. While typical RAEs have been observed in adult chess players, in this…

  5. Effects of Aging on True and False Memory Formation: An fMRI Study

    Science.gov (United States)

    Dennis, Nancy A.; Kim, Hongkeun; Cabeza, Roberto

    2007-01-01

    Compared to young, older adults are more likely to forget events that occurred in the past as well as remember events that never happened. Previous studies examining false memories and aging have shown that these memories are more likely to occur when new items share perceptual or semantic similarities with those presented during encoding. It is…

  6. Social media child in the age of endemic sexuality: a study of ...

    African Journals Online (AJOL)

    This paper entitled “Social Media Child in the Age of Endemic Sexuality: A Study of Secondary School Students in Kogi State” sought to ascertain the social media usage pattern of secondary school students in Kogi state; the influence of social media on their sexual attitude; and how the social media influence their sexual ...

  7. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index

    DEFF Research Database (Denmark)

    Minster, Ryan L; Sanders, Jason L; Singh, Jatinder

    2015-01-01

    BACKGROUND: The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. METHODS: We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted...

  8. Keep Your Brain Fit! A Psychoeducational Training Program for Healthy Cognitive Aging: A Feasibility Study

    Science.gov (United States)

    Reijnders, Jennifer; van Heugten, Caroline; van Boxtel, Martin

    2015-01-01

    A psychoeducational face-to-face training program (Keep Your Brain Fit!) was developed to support the working population in coping with age-related cognitive changes and taking proactive preventive measures to maintain cognitive health. A feasibility study was conducted to test the training program presented in a workshop format. Participants…

  9. Language Maintenance and Loss in Preschool-Age Children of Mexican Immigrants: Longitudinal Study

    Science.gov (United States)

    Guiberson, Mark M.; Barrett, Karen C.; Jancosek, Elizabeth G.; Itano, Christine Yoshinaga

    2006-01-01

    In this study, the authors plotted the Spanish language usage of 10 preschool-age children over the course of 3 years and assigned them to one of two groups: language maintenance and language loss. The authors then compared the groups' scores on structured tasks, language behaviors, and language usage/exposure variables. They found that children…

  10. Ageing and Dementia in a Longitudinal Study of a Cohort with Down Syndrome

    Science.gov (United States)

    Carr, Janet; Collins, Suzanne

    2014-01-01

    Background: A population sample of people with Down syndrome has been studied from infancy and has now been followed up again at age 47 years. Methods: Intelligence and language skills were tested and daily living skills assessed. Memory/cognitive deterioration was examined using two test instruments. Results: Scores on verbal tests of…

  11. Age at natural menopause and risk of type 2 diabetes : A prospective cohort study

    NARCIS (Netherlands)

    T. Muka (Taulant); E. Asllanaj (Eralda); N. Avazverdi (Naim); L. Jaspers (Loes); N. Stringa (Najada); J. Milic (Jelena); S. Ligthart (Symen); M.K. Ikram (Kamran); J.S.E. Laven (Joop); M. Kavousi (Maryam); A. Dehghan (Abbas); O.H. Franco (Oscar)

    2017-01-01

    markdownabstract__Aims/hypothesis__ In this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators. __Methods__ We included 3639 postmenopausal women from the

  12. Traditional-Aged College Juniors' Career Planning Self-Efficacy: A Case Study

    Science.gov (United States)

    Sherman, Dawn C.

    2012-01-01

    The purpose of this single-site case study was to explore and describe traditional-age college juniors' reports of self-efficacy (Bandura, 1997) regarding Career Planning (Barker & Kellen, 1998). More specifically, the career planning confidence levels of college juniors enrolled in a required career development course at a private business…

  13. Comment: emotion, goals, and distance: a view from the study of adult development and aging

    OpenAIRE

    Isaacowitz, Derek M; Freund, Alexandra M

    2016-01-01

    In this commentary, we consider how Balcetis’s proposals may interface with the study of motivation and emotion in lifespan developmental psychology, pointing to open questions regarding the distance perception of long-term chronic goals as well as age-related shifts from informational to emotional goals.

  14. Depression and Dementia in Aging Adults with Down Syndrome: A Case Study Approach.

    Science.gov (United States)

    Sung, Hyunsook; And Others

    1997-01-01

    A case study of three adults (ages 46-47) with Down syndrome investigated the patterns of symptoms associated with depression and dementia. Characteristics that distinguish between dementia and depression in adults with Down syndrome are described. Periodic comprehensive assessment of adults with Down syndrome to detect functioning changes is…

  15. Study of pionic specific heat in 32S-emulsion interactions at 200 AGeV

    International Nuclear Information System (INIS)

    Ghosh, Dipak; Deb, Argha; Mallick, Asok Kumar; Chatterjee, Rini; Lahiri, Madhumita; Bhattacharyya, Swarnapratim; Sahoo, Swarup Ranjan; Patra, Kanchan Kumar; Mondal, Mitali; Haldar, Prabir Kumar

    2002-01-01

    Multifractality reveals self-similarity in particle production process. Studies on multifractality of pions from 32 S-emulsion interactions at 200 AGeV by Takagi method which is assumed to be free from the shortcomings encountered by G-moment method is presented

  16. The Impact of Instrumental Music Learning on Attainment at Age 16: A Pilot Study

    Science.gov (United States)

    Hallam, Susan; Rogers, Kevin

    2016-01-01

    There is increasing international evidence that playing a musical instrument has a positive impact on attainment at school but little research has been undertaken in the UK. This study addresses this drawing on data on attainment at age 11 and 16 relating to 608 students, 115 of whom played a musical instrument. The fndings showed that the young…

  17. Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study.

    Science.gov (United States)

    Elovainio, Marko; Sommerlad, Andrew; Hakulinen, Christian; Pulkki-Råback, Laura; Virtanen, Marianna; Kivimäki, Mika; Singh-Manoux, Archana

    2017-11-07

    Social relations are important for health, particularly at older ages. We examined the salience of frequency of social contacts and marital status for cognitive ageing trajectories over 21 years, from midlife to early old age. Data are from the Whitehall II cohort study, including 4290 men and 1776 women aged 35-55 years at baseline (1985-88). Frequency of social contacts and marital status were measured in 1985-88 and 1989-90. Assessment of cognitive function on five occasions (1991-94, 1997-99, 2003-04, 2007-09 and 2012-13) included the following tests: short-term memory, inductive reasoning, verbal fluency (phonemic and semantic) and a combined global score. Cognitive trajectories over the study period were analysed using longitudinal latent growth class analyses, and the associations of these latent classes (trajectory memberships) with social relations were analysed using multinominal logistic regression. More frequent social contacts [relative risk (RRR) 0.96, 95% confidence interval (CI) 0.94 - 0.98] and being married (RRR 0.70, 95% CI 0.58 - 0.84) were associated with lower probability of being on a low rather than high cognitive performance trajectory over the subsequent 21 years. These associations persisted after adjustment for covariates. Of the sub-tests, social relations variables had the strongest association with phonemic fluency (RRR 0.95, 95% CI 0.94 - 0.97 for frequent contact; RRR 0.59, 95% CI 0.48 - 0.71 for being married). More frequent social contacts and having a spouse were associated with more favourable cognitive ageing trajectories. Further studies are needed to examine whether interventions designed to improve social connections affect cognitive ageing. © The Author 2017; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association

  18. Analysis, prediction, and case studies of early-age cracking in bridge decks

    Science.gov (United States)

    ElSafty, Adel; Graeff, Matthew K.; El-Gharib, Georges; Abdel-Mohti, Ahmed; Mike Jackson, N.

    2016-06-01

    Early-age cracking can adversely affect strength, serviceability, and durability of concrete bridge decks. Early age is defined as the period after final setting, during which concrete properties change rapidly. Many factors can cause early-age bridge deck cracking including temperature change, hydration, plastic shrinkage, autogenous shrinkage, and drying shrinkage. The cracking may also increase the effect of freeze and thaw cycles and may lead to corrosion of reinforcement. This research paper presents an analysis of causes and factors affecting early-age cracking. It also provides a tool developed to predict the likelihood and initiation of early-age cracking of concrete bridge decks. Understanding the concrete properties is essential so that the developed tool can accurately model the mechanisms contributing to the cracking of concrete bridge decks. The user interface of the implemented computer Excel program enables the user to input the properties of the concrete being monitored. The research study and the developed spreadsheet were used to comprehensively investigate the issue of concrete deck cracking. The spreadsheet is designed to be a user-friendly calculation tool for concrete mixture proportioning, temperature prediction, thermal analysis, and tensile cracking prediction. The study also provides review and makes recommendations on the deck cracking based mainly on the Florida Department of Transportation specifications and Structures Design Guidelines, and Bridge Design Manuals of other states. The results were also compared with that of other commercially available software programs that predict early-age cracking in concrete slabs, concrete pavement, and reinforced concrete bridge decks. The outcome of this study can identify a set of recommendations to limit the deck cracking problem and maintain a longer service life of bridges.

  19. 2017 Accomplishments – Tritium Aging Studies on Stainless Steel Weldments and Heat-Affected Zones

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, Michael J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hitchcock, Dale [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Krentz, Tim [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); McNamara, Joy [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Duncan, Andrew [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2018-01-31

    In this study, the combined effects tritium and decay helium in forged and welded Types 304L and 21-6-9 stainless steels were studied. To measure these effects, fracture mechanic specimens were thermally precharged with tritium and aged for approximately 17 years to build in decay helium from tritium decay prior to testing. The results are compared to earlier measurements on the same alloys and weldments (4-5, 8-9). In support of Enhanced Surveillance, “Tritium Effects on Materials”, the fracture toughness properties of long-aged tritium-charged stainless-steel base metals and weldments were measured and compared to earlier measurements. The fracture-toughness data were measured by thermally precharging as-forged and as-welded specimens with tritium gas at 34.5 MPa and 350°C and aging for approximately 17 years to build-in decay helium prior to testing. These data result from the longest aged specimens ever tested in the history of the tritium effects programs at Savannah River and the fracture toughness values measured were the lowest ever recorded for tritium-exposed stainless steel. For Type 21-6-9 stainless steel, fracture toughness values were reduced to less than 2-4% of the as-forged values to 41 lbs / in specimens that contained more than 1300 appm helium from tritium decay. The fracture toughness properties of long-aged weldments were also measured. The fracture toughness reductions were not as severe because the specimens did not retain as much tritium from the charging and aging as did the base metals. For Type 304L weldments, the specimens in this study contained approximately 600 appm helium and their fracture toughness values averaged 750 lbs / in. The results for other steels and weldments are reported and additional tests will be conducted during FY18.

  20. Estimation of natural age of menopause in Iranian women: A meta-analysis study

    Directory of Open Access Journals (Sweden)

    Abdolreza Rajaeefard

    2011-10-01

    Full Text Available Introduction: The mean age of menopause have been reported at the age of 51 in the world and regarding the increase in life expectancy in many countries more than a third of the life time of women i s in menopause period. The importance of menopause is due to its relationship with various diseases and quality of life. The present study was conducted to estimate the average natural age of menopause in women based on a meta-analysis study. Material and Methods: In a meta-analysis study on all the existing articles in the natural age o f menopause in Iran, 21 articles were selected based on inclusion criteria. Begg and Egger tests fo r publication bias and Cochrane test were used to determine the heterogeneity among samples. ???? estimate of mean calculated based on Random effect model in Stata11 software. Results: The publication bias assumption was rejected by Begg and Egger tests with significant value s equal to 0.174 and 0.446 respectively. There was a heterogeneity among samples (Q=4626.3, df=20 , P<0.001. So based on random effect model the mean age of menopause was calculated as 48.183 with 95 % CI=47.457-48.91. Conclusion: The average age of natural menopause in Iranian women is favorable to some places of Middle East, but is less compared with developed countries and the world mean. Because of the importance of this period in women, educational programs seem to be necessary.

  1. Dyslipidemia and its risk factors among urban middle-aged Iranians: A population-based study.

    Science.gov (United States)

    Ebrahimi, Hossein; Emamian, Mohammad Hassan; Hashemi, Hassan; Fotouhi, Akbar

    2016-01-01

    Dyslipidemia is a known risk factor for cardiovascular disease and is a leading cause of mortality in developed and developing countries. This study was aimed to determine the prevalence of dyslipidemia and its risk factors in an urban group of Iranian adult population. In this study, based on the criteria set by the National Cholesterol Education Program, the prevalence of dyslipidemia was evaluated in a population of 4737 people aged 45-69 years who participated in the second phase of an ophthalmology cohort study in Shahroud. Dyslipidemia prevalence was determined by age, sex, and risk factors of the disease; the findings were tested by using simple and multiple logistic regression. The prevalence of dyslipidemia was 66.5% (CI 95%: 64.4-68.6) in males, 61.3% (CI 95%: 59.5-63.2) in females, and 63.4% (CI 95%: 62.0-64.9%) in both sexes. The prevalence of hypertriglyceridemia, hypercholesterolemia, low HDL-C, and high LDL-C, respectively, was 28.8%, 13.4%, 42.3%, and 13.4%, respectively. In multivariate logistic regression model, increase of age (for females), abdominal obesity, overweight and obesity, hypertension, and diabetes were associated with an increased odd of dyslipidemia. The prevalence of dyslipidemia in middle-aged urban population in Iran is high, and with increasing age there is an increased risk of dyslipidemia. Hence, considering the growing trend of aging in Iran, there is need for taking special measures to deal with dyslipidemia as a health priority. Furthermore, the need for planning in order to reduce the risk of dyslipidemia and prevent its complications is greater than ever. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  2. Age in antiretroviral therapy programmes in South Africa: a retrospective, multicentre, observational cohort study.

    Science.gov (United States)

    Cornell, Morna; Johnson, Leigh F; Schomaker, Michael; Tanser, Frank; Maskew, Mhairi; Wood, Robin; Prozesky, Hans; Giddy, Janet; Stinson, Kathryn; Egger, Matthias; Boulle, Andrew; Myer, Landon

    2015-09-01

    As access to antiretroviral therapy (ART) expands, increasing numbers of older patients will start treatment and need specialised long-term care. However, the effect of age in ART programmes in resource-constrained settings is poorly understood. The HIV epidemic is ageing rapidly and South Africa has one of the highest HIV population prevalences worldwide. We explored the effect of age on mortality of patients on ART in South Africa and whether this effect is mediated by baseline immunological status. In this retrospective cohort analysis, we studied HIV-positive patients aged 16-80 years who started ART for the first time in six large South African cohorts of the International Epidemiologic Databases to Evaluate AIDS-Southern Africa collaboration, in KwaZulu-Natal, Gauteng, and Western Cape (two primary care clinics, three hospitals, and a large rural cohort). The primary outcome was mortality. We ascertained patients' vital status through linkage to the National Population Register. We used inverse probability weighting to correct mortality for loss to follow-up. We estimated mortality using Cox's proportional hazards and competing risks regression. We tested the interaction between baseline CD4 cell count and age. Between Jan 1, 2004, and Dec 31, 2013, 84,078 eligible adults started ART. Of these, we followed up 83,566 patients for 174,640 patient-years. 8% (1817 of 23,258) of patients aged 16-29 years died compared with 19% (93 of 492) of patients aged 65 years or older. The age adjusted mortality hazard ratio was 2·52 (95% CI 2·01-3·17) for people aged 65 years or older compared with those 16-29 years of age. In patients starting ART with a CD4 count of less than 50 cells per μL, the adjusted mortality hazard ratio was 2·52 (2·04-3·11) for people aged 50 years or older compared with those 16-39 years old. Mortality was highest in patients with CD4 counts of less than 50 cells per μL, and 15% (1103 of 7295) of all patients aged 50 years or older

  3. Ageing Studies on the First Resistive-MicroMeGaS Quadruplet at GIF++ Preliminary Results

    Directory of Open Access Journals (Sweden)

    Alvarez Gonzalez B.

    2018-01-01

    Full Text Available A resistive-MicroMeGaS quadruplet built at CERN has been installed at the new CERN Gamma Irradiation Facility (GIF++ with the aim of carrying out a long-term ageing study. Two smaller resistive bulk-MicroMeGaS produced at the CERN PCB workshop have also been installed at GIF++ in order to provide a comparison of the ageing behavior with the MicroMeGaS quadruplet. We give an overview of the ongoing tests at GIF++ in terms of particle rate, integrated charge and spatial resolution of the MicroMeGaS detectors.

  4. Contribution to the study of the kinetics of maraging steel aging

    International Nuclear Information System (INIS)

    Santos Victor, O.B. dos.

    1990-01-01

    Maraging steels are materials with very low contents of C and with Ni, Co, Mo and T1 additions, that can reach very high mechanical strength values by combinations of heat treatment operations. Three 18% Ni Maraging steels have had some aspects of their aging kinetics investigated by experimental procedures using electrical resistivity, internal friction and hardness measurement techniques, in samples aged from 30 seconds to several hours. Finally, it was verified that the techniques employed were very adequate to the purposes of the present kinetics studies. (author)

  5. Ageing-induced enhancement of open porosity of mesoporous silica films studied by positron annihilation spectroscopy

    International Nuclear Information System (INIS)

    He Chunqing; Muramatsu, Makoto; Oshima, Nagayasu; Ohdaira, Toshiyuki; Kinomura, Atsushi; Suzuki, Ryoichi

    2006-01-01

    We show that ageing of the silica sol in a closed vessel enhanced the open porosity of calcined mesoporous silica film studied by positron. Positron annihilation lifetime spectroscopy (PALS) based on a pulsed slow positron beam was used to estimate the mesopore size. 2-dimensional PALS (2D-PALS) and ortho-positronium time-of-flight (Ps-TOF) were used to evaluate the open porosity, interconnectivity and tortuosity of mesopores in the silica films. Results revealed that little change in pore size but significant enhancement of open porosity and/or pore interconnectivity occurred in the silica film deposited after the precursor solution aged for a relative longer time

  6. Radiogenic age and isotopic studies: report 9. Current research 1995-F

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    `Radiogenic Age and Isotopic Studies` is an annual collection of research presentations containing U-Pb, Sm-Nd, Rb-Sr, and {sup 40}Ar-{sup 39}Ar data generated by the Geochronology Laboratory under the auspices of the Continental Geoscience Division, Geological Survey of Canada. Report 9 contains 5 papers from regions across Canada, followed by a compilation of {sup 40}Ar-{sup 39}Ar and K-Ar ages. Authors herein present data, relate results to field settings, and make brief interpretations. Readers are thus reminded that much of the research encompassed represents `work-in-progress` and that more extensive publications may follow at a later date.

  7. Aging Studies on the First Resistive-Micromegas Quadruplet at GIF++

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00022061; The ATLAS collaboration; Iengo, Paolo; Bianco, Michele; Farina, Edoardo Maria; Sidiropoulou, Ourania; Kuger, Fabian; Longo, Luigi; Sekhniaidze, Givi; Lin, Tai-Hua; Schott, Matthias; Valderanis, Chrysostomos; Wotschack, Jorg

    2015-01-01

    A resistive-micromegas quadruplet built at CERN has been installed at the new CERN Gamma Irradiation Facility (GIF++) with the aim of carrying out a long-term aging study. Two smaller resistive bulk-micromegas produced at the CERN PCB workshop have also been installed at GIF++ in order to provide a comparison of the aging behavior with the micromegas quadruplet. We give an overview of the ongoing tests at GIF++ in terms of particle rate, integrated charge and spatial resolution of the micromegas detectors.

  8. Radiogenic age and isotopic studies: report 9. Current research 1995-F

    International Nuclear Information System (INIS)

    1996-01-01

    'Radiogenic Age and Isotopic Studies' is an annual collection of research presentations containing U-Pb, Sm-Nd, Rb-Sr, and 40 Ar- 39 Ar data generated by the Geochronology Laboratory under the auspices of the Continental Geoscience Division, Geological Survey of Canada. Report 9 contains 5 papers from regions across Canada, followed by a compilation of 40 Ar- 39 Ar and K-Ar ages. Authors herein present data, relate results to field settings, and make brief interpretations. Readers are thus reminded that much of the research encompassed represents 'work-in-progress' and that more extensive publications may follow at a later date

  9. Trends in Dementia Incidence in a Birth Cohort Analysis of the Einstein Aging Study.

    Science.gov (United States)

    Derby, Carol A; Katz, Mindy J; Lipton, Richard B; Hall, Charles B

    2017-11-01

    Trends in dementia incidence rates have important implications for planning and prevention. To better understand incidence trends over time requires separation of age and cohort effects, and few prior studies have used this approach. To examine trends in dementia incidence and concomitant trends in cardiovascular comorbidities among individuals aged 70 years or older who were enrolled in the Einstein Aging Study between 1993 and 2015. In this birth cohort analysis of all-cause dementia incidence in persons enrolled in the Einstein Aging Study from October 20, 1993, through November 17, 2015, a systematically recruited, population-based sample of 1348 participants from Bronx County, New York, who were 70 years or older without dementia at enrollment and at least one annual follow-up was studied. Poisson regression was used to model dementia incidence as a function of age, sex, educational level, race, and birth cohort, with profile likelihood used to identify the timing of significant increases or decreases in incidence. Birth year and age. Incident dementia defined by consensus case conference based on annual, standardized neuropsychological and neurologic examination findings, using criteria from the DSM-IV. Among 1348 individuals (mean [SD] baseline age, 78.5 [5.4] years; 830 [61.6%] female; 915 [67.9%] non-Hispanic white), 150 incident dementia cases developed during 5932 person-years (mean [SD] follow-up, 4.4 [3.4] years). Dementia incidence decreased in successive birth cohorts. Incidence per 100 person-years was 5.09 in birth cohorts before 1920, 3.11 in the 1920 through 1924 birth cohorts, 1.73 in the 1925 through 1929 birth cohorts, and 0.23 in cohorts born after 1929. Change point analyses identified a significant decrease in dementia incidence among those born after July 1929 (95% CI, June 1929 to January 1930). The relative rate for birth cohorts before July 1929 vs after was 0.13 (95% CI, 0.04-0.41). Prevalence of stroke and myocardial infarction

  10. MR imaging of capitellar ossification: a study in children of different ages

    International Nuclear Information System (INIS)

    Fader, Lauren M.; Laor, Tal; Eismann, Emily A.; Cornwall, Roger; Little, Kevin J.

    2014-01-01

    The capitellar ossification center is used routinely to evaluate elbow alignment on radiography. However, whether capitellar ossification is central and concentric to support this practice is unknown. To define the pattern of capitellar ossification at different ages of childhood. This HIPAA-compliant study was IRB approved. MR imaging examinations from 81 children (ages 1-13 years, at least 3 boys and 3 girls in each age group) were included. We determined the center points of the ossified capitellum and the cartilaginous capitellum on the sagittal and coronal sequences that best showed differentiation between cartilage and bone. Percentage offset of the center of the ossified capitellum from the center of the cartilaginous capitellum was calculated in anterior-posterior, proximal-distal and medial-lateral dimensions, and compared across age groups and between genders. Linear regressions were used to ascertain the effect of age on percentage offset for all patients and for each gender. Capitellar ossification begins eccentrically with sagittal anterior proximal offset and coronal medial offset. With age, ossification proceeds posteriorly, distally and laterally. Percentage offset gradually diminishes with age. The ossified capitellum centralizes in the sagittal plane by 12-13 years. In the coronal plane, the capitellum ossifies medially beyond the proximal radioulnar joint and remains eccentric at 12-13 years. Centralization in boys lags in the anterior-posterior dimension. Capitellar ossification is an eccentric process, with lag in anterior-posterior centralization in boys. Medial offset persists at 12-13 years. Recognition of this eccentric ossification may allow for more accurate assessment of elbow alignment on radiographs, especially in younger children. (orig.)

  11. B12 deficiency increases with age in hospitalized patients: a study on 14,904 samples.

    Science.gov (United States)

    Mézière, Anthony; Audureau, Etienne; Vairelles, Stéphane; Krypciak, Sébastien; Dicko, Michèle; Monié, Marguerite; Giraudier, Stéphane

    2014-12-01

    Cobalamin deficiency is responsible for hematological, neurological, neurocognitive, and neuropsychiatric impairments and is a risk factor for cardiovascular diseases, particularly in the elderly people. In order to determine B12 status in old inpatients, a total number of 14,904 hospitalized patients in whom B12 measurements were performed in five hospitals in the Paris metropolitan area were included from January 1, 2011 to December 31, 2011. The aims of the study were to determine whether age had an impact on B12 and folate deficiencies and to evaluate correlations between B12 and biological parameters-folate, hemoglobin, mean cell volume, homocystein (tHcy)-and age. Patients were aged 70.3±19.5 years. Low B12 concentration ( 17 µmol/L), 20.4% had low folate concentration (folate 17 µmol/L), and 4.7% of patients were both functional B12 and folate deficient. The B12 or folate deficient patients had lower mean cell volume level than nondeficient patients. Increase in mean cell volume and tHcy concentrations with age and decrease in B12, folate, and hemoglobin levels with age were observed. Frequency of functional B12 deficiency was 9.6% in patients aged 30-60 years and 14.2% in patients over 90 years. Frequency of functional folate deficiency was 9.5% in 30-60 years and 12.1% in >90 years. In inpatients, functional B12 deficiency and functional folate deficiency increase with age and are not associated with anemia or macrocytosis. False vitamin B deficiencies are frequent. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  12. Variation in referral and access to new psychological therapy services by age: an empirical quantitative study.

    Science.gov (United States)

    Pettit, Sophie; Qureshi, Adam; Lee, William; Stirzaker, Alex; Gibson, Alex; Henley, William; Byng, Richard

    2017-07-01

    Older people with common mental health problems (CMHPs) are known to have reduced rates of referral to psychological therapy. To assess referral rates to the Improving Access to Psychological Therapies (IAPT) services, contact with a therapist, and clinical outcome by age. Empirical research study using patient episodes of care from South West of England IAPT services. By analysing 82 513 episodes of care (2010-2011), referral rates and clinical improvement were compared with both total population and estimated prevalence in each age group using IAPT data. Probable recovery of those completing treatment was calculated for each group. Estimated prevalence of CMHPs peaks in 45-49-year-olds (20.59% of population). The proportions of patients identified with CMHPs being referred peaks at 20-24 years (22.95%) and reduces with increase in age thereafter to 6.00% for 70-74-year-olds. Once referred, the proportion of those attending first treatment increases with age between 20 years (57.34%) and 64 years (76.97%). In addition, the percentage of those having a clinical improvement gradually increases from the age of 18 years (12.94%) to 69 years (20.74%). Younger adults are more readily referred to IAPT services. However, as a proportion of those referred, probabilities of attending once, attending more than once, and clinical improvement increase with age. It is uncertain whether optimum levels of referral have been reached for young adults. It is important to establish whether changes to service configuration, treatment options, and GP behaviour can increase referrals for middle-aged and older adults. © British Journal of General Practice 2017.

  13. Brain volumes in healthy adults aged 40 years and over: a voxel-based morphometry study.

    Science.gov (United States)

    Riello, Roberta; Sabattoli, Francesca; Beltramello, Alberto; Bonetti, Matteo; Bono, Giorgio; Falini, Andrea; Magnani, Giuseppe; Minonzio, Giorgio; Piovan, Enrico; Alaimo, Giuseppina; Ettori, Monica; Galluzzi, Samantha; Locatelli, Enrico; Noiszewska, Malgorzata; Testa, Cristina; Frisoni, Giovanni B

    2005-08-01

    Gender and age effect on brain morphology have been extensively investigated. However, the great variety in methods applied to morphology partly explain the conflicting results of linear patterns of tissue changes and lateral asymmetry in men and women. The aim of the present study was to assess the effect of age, gender and laterality on the volumes of gray matter (GM) and white matter (WM) in a large group of healthy adults by means of voxel-based morphometry. This technique, based on observer-independent algorithms, automatically segments the 3 types of tissue and computes the amount of tissue in each single voxel. Subjects were 229 healthy subjects of 40 years of age or older, who underwent magnetic resonance (MR) for reasons other than cognitive impairment. MR images were reoriented following the AC-PC line and, after removing the voxels below the cerebellum, were processed by Statistical Parametric Mapping (SPM99). GM and WM volumes were normalized for intracranial volume. Women had more fractional GM and WM volumes than men. Age was negatively correlated with both fractional GM and WM, and a gender x age interaction effect was found for WM, men having greater WM loss with advancing age. Pairwise differences between left and right GM were negative (greater GM in right hemisphere) in men, and positive (greater GM in left hemisphere) in women (-0.56+/-4.2 vs 0.99+/-4.8; p=0.019). These results support side-specific accelerated WM loss in men, and may help our better understanding of changes in regional brain structures associated with pathological aging.

  14. MR imaging of capitellar ossification: a study in children of different ages

    Energy Technology Data Exchange (ETDEWEB)

    Fader, Lauren M. [University of Cincinnati College of Medicine, Cincinnati, OH (United States); Laor, Tal [Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States); Eismann, Emily A.; Cornwall, Roger; Little, Kevin J. [Cincinnati Children' s Hospital Medical Center, Division of Orthopaedic Surgery, Cincinnati, OH (United States)

    2014-08-15

    The capitellar ossification center is used routinely to evaluate elbow alignment on radiography. However, whether capitellar ossification is central and concentric to support this practice is unknown. To define the pattern of capitellar ossification at different ages of childhood. This HIPAA-compliant study was IRB approved. MR imaging examinations from 81 children (ages 1-13 years, at least 3 boys and 3 girls in each age group) were included. We determined the center points of the ossified capitellum and the cartilaginous capitellum on the sagittal and coronal sequences that best showed differentiation between cartilage and bone. Percentage offset of the center of the ossified capitellum from the center of the cartilaginous capitellum was calculated in anterior-posterior, proximal-distal and medial-lateral dimensions, and compared across age groups and between genders. Linear regressions were used to ascertain the effect of age on percentage offset for all patients and for each gender. Capitellar ossification begins eccentrically with sagittal anterior proximal offset and coronal medial offset. With age, ossification proceeds posteriorly, distally and laterally. Percentage offset gradually diminishes with age. The ossified capitellum centralizes in the sagittal plane by 12-13 years. In the coronal plane, the capitellum ossifies medially beyond the proximal radioulnar joint and remains eccentric at 12-13 years. Centralization in boys lags in the anterior-posterior dimension. Capitellar ossification is an eccentric process, with lag in anterior-posterior centralization in boys. Medial offset persists at 12-13 years. Recognition of this eccentric ossification may allow for more accurate assessment of elbow alignment on radiographs, especially in younger children. (orig.)

  15. Treadmill Exercise Attenuates Retinal Oxidative Stress in Naturally-Aged Mice: An Immunohistochemical Study

    Directory of Open Access Journals (Sweden)

    Chan-Sik Kim

    2015-09-01

    Full Text Available In the retina, a number of degenerative diseases, including glaucoma, diabetic retinopathy, and age-related macular degeneration, may occur as a result of aging. Oxidative damage is believed to contribute to the pathogenesis of aging as well as to age-related retinal disease. Although physiological exercise has been shown to reduce oxidative stress in rats and mice, it is not known whether it has a similar effect in retinal tissues. The aim of this study was to evaluate retinal oxidative stress in naturally-aged mice. In addition, we evaluated the effects of aerobic training on retinal oxidative stress by immunohistochemically evaluating oxidative stress markers. A group of twelve-week-old male mice were not exercised (young control. Two groups of twenty-two-month-old male mice were created: an old control group and a treadmill exercise group. The old control group mice were not exercised. The treadmill exercise group mice ran on a treadmill (5 to 12 m/min, 30 to 60 min/day, 3 days/week for 12 weeks. The retinal thickness and number of cells in the ganglion cell layer of the naturally-aged mice were reduced compared to those in the young control mice. However, treadmill exercise reversed these morphological changes in the retinas. We evaluated retinal expression of carboxymethyllysine (CML, 8-hydroxy-2′-deoxyguanosine (8-OHdG and nitrotyrosine. The retinas from the aged mice showed increased CML, 8-OHdG, and nitrotyrosine immunostaining intensities compared to young control mice. The exercise group exhibited significantly lower CML levels and nitro-oxidative stress than the old control group. These results suggest that regular exercise can reduce retinal oxidative stress and that physiological exercise may be distinctly advantageous in reducing retinal oxidative stress.

  16. Prevalence of cognitive impairment in individuals aged over 65 in an urban area: DERIVA study.

    Science.gov (United States)

    Rodríguez-Sánchez, Emiliano; Mora-Simón, Sara; Patino-Alonso, María C; García-García, Ricardo; Escribano-Hernández, Alfonso; García-Ortiz, Luis; Perea-Bartolomé, Ma Victoria; Gómez-Marcos, Manuel A

    2011-11-17

    Few data are available on the prevalence of cognitive impairment (CI) in Spain, and the existing information shows important variations depending on the geographical setting and the methodology employed. The aim of this study was to determine the prevalence of CI in individuals aged over 65 in an urban area, and to analyze its associated risk factors. A descriptive, cross-sectional, home questionnaire-based study; Populational, urban setting. The reference population comprised over-65s living in the city of Salamanca (Spain) in 2009. Randomized sampling stratified according to health district was carried out, and a total of 480 people were selected. In all, 327 patients were interviewed (68.10%), with a mean age of 76.35 years (SD: 7.33). Women accounted for 64.5% of the total. A home health questionnaire was used to obtain the following data: age, sex, educational level, family structure, morbidity and functionality. All participants completed a neuropsychological test battery. The prevalence data were compared with those of the European population, with direct adjustment for age and sex. Diagnoses were divided into three general categories: normal cognitive function, cognitive impairment - no dementia (CIND), and dementia. The prevalence of CI among these over-65s was 19% (14.7% CIND and 4.3% dementia). The age-and sex-adjusted global prevalence of CI was 14.9%. CI increased with age (p < 0.001) and decreased with increasing educational level (p < 0.001). Significant risk factors were found with the multivariate analyses: age (OR = 1.08, 95%CI: 1.03-1.12), anxiety-depression (OR = 3.47, 95%CI: 1.61-7.51) and diabetes (OR = 2.07, 95%CI: 1.02-4.18). In turn, years of education was found to be a protective factor (OR = 0.79, 95%CI: 0.70-0.90). Although CI was more frequent among women and in people living without a partner, these characteristics were not significantly associated with CI risk. The observed raw prevalence of CI was 19% (14.9% after adjusting for age

  17. Study of cerebral metabolism of glucose in normal human brain correlated with age

    International Nuclear Information System (INIS)

    Si, M.

    2007-01-01

    sensory-motor cortex(BA5, 7).In spite of the cerebral atrophy of aging, these relative hypometabolic brain areas are considered to be correlated with structural and functional cerebral changes and cognitive dysfunction such as verbal and spatial working memory deficit in the process of normal brain aging. The study of cerebral metabolism of glucose in normal human brains can be used for reference and instruction in future clinical studies and in normal brain aging. (author)

  18. Aging in autonomic control by multifractal studies of cardiac interbeat intervals in the VLF band

    International Nuclear Information System (INIS)

    Makowiec, Danuta; Kryszewski, Stanisław; Rynkiewicz, Andrzej; Wdowczyk-Szulc, Joanna; Żarczyńska-Buchowiecka, Marta; Gałąska, Rafał

    2011-01-01

    The heart rate responds dynamically to various intrinsic and environmental stimuli. The autonomic nervous system is said to play a major role in this response. Multifractal analysis offers a novel method to assess the response of cardiac interbeat intervals. Twenty-four hour ECG recordings of RR interbeat intervals (of 48 elderly volunteers (age 65–94), 40 middle-aged persons (age 45–53) and 36 young adults (age 18–26)) were investigated to study the effect of aging on autonomic regulation during normal activity in healthy adults. Heart RR-interval variability in the very low frequency (VLF) band (32–420 RR intervals) was evaluated by multifractal tools. The nocturnal and diurnal signals of 6 h duration were studied separately. For each signal, the analysis was performed twice: for a given signal and for the integrated signal. A multifractal spectrum was quantified by the h max value at which a multifractal spectrum attained its maximum, width of a spectrum, Hurst exponent, extreme events h left and distance between the maxima of a signal and its integrated counterpart. The following seven characteristics are suggested as quantifying the age-related decrease in the autonomic function ('int' refers to the integrated signal): (a) h sleep max − h max wake > 0.05 for a signal; (b) h int max > 1.15 for wake; (c) h int max − h max > 0.85 for sleep; (d) Hurst wake − Hurst sleep < 0.01; (e) width wake > 0.07; (f) width int < 0.30 for sleep; (g) h int left > 0.75. Eighty-one percent of elderly people had at least four of these properties, and ninety-two percent of young people had three or less. This shows that the multifractal approach offers a concise and reliable index of healthy aging for each individual. Additionally, the applied method yielded insights into dynamical changes in the autonomic regulation due to the circadian cycle and aging. Our observations support the hypothesis that imbalance in the autonomic control due to healthy aging could

  19. Evidence for Cognitive Aging in Midlife Women: Study of Women's Health Across the Nation.

    Directory of Open Access Journals (Sweden)

    Arun S Karlamangla

    Full Text Available Although cross-sectional studies suggest that cognitive aging starts in midlife, few longitudinal studies have documented within-individual declines in cognitive performance before the seventh decade. Learning from repeat testing, or practice effects, can mask the decline in younger cohorts. In women, the menopause transition also affects test performance and can confound estimates of underlying decline. We designed this study to determine if, after controlling for practice effects, the menopause transition, and the symptoms associated with it, there is evidence of cognitive aging in midlife women. We used data from a longitudinal observational study in 2,124 participants from the Study of Women's Health Across the Nation. Outcomes examined were scores on annual tests of processing speed, verbal episodic memory (immediate and delayed, and working memory. To reduce the impact of practice effects and of the menopause transition, we used the third cognition testing visit as the baseline. Average age at this baseline was 54 years, and the majority of the women were postmenopausal; half the cohort was 2 or more years beyond the final menstrual period. There were 7,185 cognition assessments with median follow-up time of 6.5 years. In mixed effects regression, adjusted for practice effects, retention, menopause symtoms (depressive, anxiety, vasomotor, and sleep disturbance, and covariates, scores on 2 of 4 cognition tests declined. Mean decline in cognitive speed was 0.28 per year (95% confidence interval [CI] 0.20 to 0.36 or 4.9% in 10 years, and mean decline in verbal episodic memory (delayed testing was 0.02 per year (95% CI: 0.00 to 0.03 or 2% in 10 years. Our results provide strong, longitudinal evidence of cognitive aging in midlife women, with substantial within-woman declines in processing speed and memory. Further research is needed to identify factors that influence decline rates and to develop interventions that slow cognitive aging.

  20. Glaucomatous Optic Neuropathy Associated with Nocturnal Dip in Blood Pressure: Findings from the Maracaibo Aging Study.

    Science.gov (United States)

    Melgarejo, Jesús D; Lee, Joseph H; Petitto, Michele; Yépez, Juan B; Murati, Felipe A; Jin, Zhezhen; Chávez, Carlos A; Pirela, Rosa V; Calmón, Gustavo E; Lee, Winston; Johnson, Matthew P; Mena, Luis J; Al-Aswad, Lama A; Terwilliger, Joseph D; Allikmets, Rando; Maestre, Gladys E; De Moraes, C Gustavo

    2018-01-05

    To determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics. Observational cross-sectional study. A subset (n = 93) of the participants from the Maracaibo Aging Study (MAS) who met the study eligibility criteria were included. These participants, who were at least 40 years of age, had measurements for optical tomography coherence, visual field (VF) tests, 24-hour BP, office BP, and intraocular pressure 20% compared with daytime BP) were significant risk factors for glaucomatous damage (odds ratio, 19.78 and 5.55, respectively). In this population, the link between nocturnal BP and GON is determined by extreme dipping effects rather than low nocturnal BP levels alone. Further studies considering extreme decreases in nocturnal BP in individuals at high risk of glaucoma are warranted. Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  1. Imbalanced geodemographical structures in Târnave regional system. Case study: population ageing.

    Directory of Open Access Journals (Sweden)

    H.-V. CONȚIU

    2017-05-01

    Full Text Available The demographic prospects of a regional system, the natural dynamics of the population, the potential of manpower resources, planning and forecast of its use, show a high degree of dependence on the demographical structure by age, the identified imbalances involving an increase in the vulnerability of the regional system and therefore an enhancement of geodemographical risks (acceleration of population ageing, decreasing population trend, disappearance of some rural settlements, socio-economic failures etc.. In this study, a special attention is paid to the analysis of ageing index and demographical dependency ratio, and the share of young and old people to the Târnave regional system, taking into account as milestones, the population censuses from 1910, 1992 2002 and 2011.

  2. A feasibility study on age-related factors of wrist pulse using principal component analysis.

    Science.gov (United States)

    Jang-Han Bae; Young Ju Jeon; Sanghun Lee; Jaeuk U Kim

    2016-08-01

    Various analysis methods for examining wrist pulse characteristics are needed for accurate pulse diagnosis. In this feasibility study, principal component analysis (PCA) was performed to observe age-related factors of wrist pulse from various analysis parameters. Forty subjects in the age group of 20s and 40s were participated, and their wrist pulse signal and respiration signal were acquired with the pulse tonometric device. After pre-processing of the signals, twenty analysis parameters which have been regarded as values reflecting pulse characteristics were calculated and PCA was performed. As a results, we could reduce complex parameters to lower dimension and age-related factors of wrist pulse were observed by combining-new analysis parameter derived from PCA. These results demonstrate that PCA can be useful tool for analyzing wrist pulse signal.

  3. The study of evaluation methodology of the aging and degradation researches

    International Nuclear Information System (INIS)

    Cho, C. J.; Park, Z. H.; Jeong, I. S.

    2001-01-01

    To judge the usefulness of aging related researches like PLIM (Plant lifetime Management) and aging related degradation, et. al. in PSR(Periodic Safety Review), the evaluation methodology of the R and D have been proposed up to now are reviewed. The infometric methodology is considered to be the optimum method for the evaluation of the nuclear related researches. And finally, to increase the objectiveness and reliability of the infometric methodology in the aging and degradation researches, the indexes of safety, technology and economics are introduced. From this study, the infometric methodology has the advantage of the actual engineering evaluation in the nuclear related researches with other methodologies, but for the further research, the effective construction of DB and survey of various statistics in the technical reports and papers are needed

  4. Spectroscopic studies of the physical origin of environmental aging effects on doped graphene

    International Nuclear Information System (INIS)

    Chang, J.-K.; Hsu, C.-C.; Liu, S.-Y.; Wu, C.-I.; Gharib, M.; Yeh, N.-C.

    2016-01-01

    The environmental aging effect of doped graphene is investigated as a function of the organic doping species, humidity, and the number of graphene layers adjacent to the dopant by studies of the Raman spectroscopy, x-ray and ultraviolet photoelectron spectroscopy, scanning electron microscopy, infrared spectroscopy, and electrical transport measurements. It is found that higher humidity and structural defects induce faster degradation in doped graphene. Detailed analysis of the spectroscopic data suggest that the physical origin of the aging effect is associated with the continuing reaction of H_2O molecules with the hygroscopic organic dopants, which leads to formation of excess chemical bonds, reduction in the doped graphene carrier density, and proliferation of damages from the graphene grain boundaries. These environmental aging effects are further shown to be significantly mitigated by added graphene layers.

  5. Incidence of cervical cancer after several negative smear results by age 50: prospective observational study

    DEFF Research Database (Denmark)

    Rebolj, Matejka; van Ballegooijen, Marjolein; Lynge, Elsebeth

    2009-01-01

    /100,000 (95% confidence interval 33 to 51) in the younger group and 36/100,000 (24 to 52) in the older group (P=0.48). The cumulative incidence rate of cervical intraepithelial neoplasia grade I+ was twice as high in the younger than in the older group (Pcervical cancer......OBJECTIVE: To determine the incidence of cervical cancer after several negative cervical smear tests at different ages. DESIGN: Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry...... of histopathology and cytopathology (PALGA). SETTING: Netherlands, national data. Population 218,847 women aged 45-54 and 445,382 aged 30-44 at the time of the third negative smear test. MAIN OUTCOME MEASURES: 10 year cumulative incidence of interval cervical cancer. RESULTS: 105 women developed cervical cancer...

  6. Influence of memory, attention, IQ and age on auditory temporal processing tests: preliminary study.

    Science.gov (United States)

    Murphy, Cristina Ferraz Borges; Zachi, Elaine Cristina; Roque, Daniela Tsubota; Ventura, Dora Selma Fix; Schochat, Eliane

    2014-01-01

    To investigate the existence of correlations between the performance of children in auditory temporal tests (Frequency Pattern and Gaps in Noise--GIN) and IQ, attention, memory and age measurements. Fifteen typically developing individuals between the ages of 7 to 12 years and normal hearing participated in the study. Auditory temporal processing tests (GIN and Frequency Pattern), as well as a Memory test (Digit Span), Attention tests (auditory and visual modality) and intelligence tests (RAVEN test of Progressive Matrices) were applied. Significant and positive correlation between the Frequency Pattern test and age variable were found, which was considered good (p<0.01, 75.6%). There were no significant correlations between the GIN test and the variables tested. Auditory temporal skills seem to be influenced by different factors: while the performance in temporal ordering skill seems to be influenced by maturational processes, the performance in temporal resolution was not influenced by any of the aspects investigated.

  7. Sex and age related differences in postmyelographic adverse reactions. A prospective study of 1765 myelographies

    Energy Technology Data Exchange (ETDEWEB)

    Maly, P

    1989-09-01

    Differences in frequency of postmyelographic adverse reactions were analyzed with respect to sex and age in a prospective study including 1026 patients injected with metrizamide and 739 injected with iohexol. Regardless of the type of contrast medium or myelography, all types of adverse reactions were 1.4-3.8 times as frequent in women as in men. Most of the differences were statistically significant. Headache was more frequent, while vomiting and dizziness were less frequent in both women and men aged 26-50 years compared with those over 50 years of age. Dizziness and increased low back pain were consistently reported spontaneously by the patients less frequently than emerged via formal interview. The large differences between the sexes suggest that further research on contrast media toxicity would be best performed with separation of the data by gender. (orig.).

  8. Parenting style in childhood and mortality risk at older ages: a longitudinal cohort study.

    Science.gov (United States)

    Demakakos, Panayotes; Pillas, Demetris; Marmot, Michael; Steptoe, Andrew

    2016-08-01

    Parenting style is associated with offspring health, but whether it is associated with offspring mortality at older ages remains unknown. We examined whether childhood experiences of suboptimal parenting style are associated with increased risk of death at older ages. Longitudinal cohort study of 1964 community-dwelling adults aged 65-79 years. The association between parenting style and mortality was inverse and graded. Participants in the poorest parenting style score quartile had increased risk of death (hazard ratio (HR) = 1.72, 95% CI 1.20-2.48) compared with those in the optimal parenting style score quartile after adjustment for age and gender. Full adjustment for covariates partially explained this association (HR = 1.49, 95% CI 1.02-2.18). Parenting style was inversely associated with cancer and other mortality, but not cardiovascular mortality. Maternal and paternal parenting styles were individually associated with mortality. Experiences of suboptimal parenting in childhood are associated with increased risk of death at older ages. © The Royal College of Psychiatrists 2016.

  9. Housing for ageing LGBTQ people in Sweden: a descriptive study of needs, preferences, and concerns.

    Science.gov (United States)

    Kottorp, A; Johansson, K; Aase, P; Rosenberg, L

    2016-09-01

    With an increasing number of ageing people who identify themselves as lesbian, gay, bisexual, transgender, or queer (LGBTQ), there is a risk that traditional housing for older people fails to meet the needs of these people. The aim of this study was to describe LGBTQ people's needs, preferences, and concerns according to ageing and housing. Based on a survey (n = 487), and six focus-group discussions (n = 30), with LGBTQ persons, quantitative and qualitative approaches were used to analyse the findings. When comparing the ranking of preferences (in terms of activity options, environmental features, and staff competence) in a senior housing setting between the LGBTQ people (n = 200) and heterosexual matched controls (n = 198), only minor differences were detected. The findings from the focus groups included: (1) a dilemma between segregation and openness, (2) the importance of safety associated with ageing together with persons with similar experiences, and (3) networks of persons at different ages connected through close friendship supported participation in activities in LGBTQ-profiled senior housing. The findings provide knowledge to improve awareness of sexual orientation when it comes to needs and preferences in relation to ageing and housing in a Swedish context.

  10. Parenting style in childhood and mortality risk at old age: a longitudinal cohort study

    Science.gov (United States)

    Demakakos, Panayotes; Pillas, Demetris; Marmot, Michael; Steptoe, Andrew

    2018-01-01

    Background Parenting style is associated with offspring health, but whether it is associated with offspring mortality at older ages remains unknown. Aims We examined whether childhood experiences of suboptimal parenting style are associated with increased risk of death at older ages. Method Longitudinal cohort study of 1,964 community-dwelling adults aged 65 to 79 years. Results The association between parenting style and mortality was inverse and graded. Participants in the poorest parenting style score quartile had increased risk of death (hazard ratio (HR) 1.72; 95% CI, 1.20-2.48) compared with those in the optimal parenting style score quartile after adjustment for age and sex. Full adjustment for covariates partially explained this association (HR 1.49; 95% CI, 1.02-2.18). Parenting style was inversely associated with cancer and other mortality, but not cardiovascular mortality. Maternal and paternal parenting styles were individually associated with mortality. Conclusions Experiences of suboptimal parenting in childhood are associated with increased risk of death at older ages. PMID:26941265

  11. Age at onset typology in opioid dependent men: an exploratory study.

    Science.gov (United States)

    De, Biswajit; Mattoo, Surendra K; Basu, Debasish

    2002-04-01

    This study attempted to apply age at onset typology in ICD-10 diagnosed opioid dependence. The sample comprised 80 men seeking treatment at an addiction clinic. The measures included socio-demographic and clinical profile, Severity of Opioid Dependence Questionnaire, Modified Sensation Seeking Scale, Multiphasic Personality Questionnaire (MPQ) and Family History Assessment Module. A cut-off age of 20/21 years for an early-onset late-onset typology of opioid dependence was obtained using two methods - the modal age at onset method and one-third sample by age at onset method. The early onset group showed significant differences in terms of it being more often younger, urban, unmarried, wage earning or students, using oral opioids (not heroin or injectables), showing higher lifetime use and dependence of sedatives, earlier onset of use and dependence of sedatives and tobacco, and higher global psychopathology in terms of MPQ. The early onset group also showed statistically insignificant trends for lesser use and dependence of alcohol, higher severity of opioid dependence, more legal and less social complications, higher sensation seeking (except boredom susceptibility), and more frequent substance dependence in first degree relatives. The age at onset typology in opioid dependence appears to be feasible and having some similarities to similar typology in alcoholism.

  12. Electron microscopic radioautographic studies on macromolecular synthesis in mitochondria of animal cells in aging

    International Nuclear Information System (INIS)

    Nagata, Tetsuji

    2010-01-01

    Study aging changes of intramitochondrial DNA, RNA, protein synthesis of mouse organs during the development and aging, 30 groups of developing and aging mice (3 individuals each), from fetal day 19 to postnatal newborn at day 1, 3, 9, 14 and adult at month 1, 2, 6, 12 to 24, were injected with either 3 H-thymidine, 3 H-uriidine, or 3 H-leucine, sacrificed 1 h later and liver, adrenal, lung and testis tissues observed by electron microscopic radioautography. Accordingly, numbers of mitochondria per cell profile area, numbers of labeled mitochondria and the mitochondrial labeling index labeled with 3 H-labeled precursors showing DNA, RNA, protein synthesis in these cells (hepatocytes, 3 zones of the adrenal cortices - zona glomerulosa, fasciculata and reticularis -, adrenal medullary cells, pulmonary cells and testis cells) were counted per cells and compared among the respective developing and aging groups. The numbers of mitochondria in these cells increased from fetal day 19 to postnatal month 1 and 2. However, the numbers of labeled mitochondria and the labeling indices of intramitochondrial DNA, RNA, protein syntheses incorporating the 3 H-labeled precursors in the described tissue cells increased from fetal day 19 to postnatal month 1 and decreased to month 24. These data support that the activity of intramitochnodrial DNA, RNA, protein syntheses in cells of these tissues increased and decreased by development and aging in mice. The intramitochondrial DNA, RNA and protein syntheses in some other organs were also reviewed and discussed. (author)

  13. Association of Mandible Anatomy with Age, Gender, and Dental Status: A Radiographic Study

    International Nuclear Information System (INIS)

    Chole, Revant H.; Patil, Ranjitkumar N.; Balsaraf Chole, Swati; Gondivkar, Shailesh; Gadbail, Amol R.; Yuwanati, Monal B.

    2013-01-01

    Introduction. Gonial angle and antegonial region are important landmarks in mandible which is influenced by gender, age, and dental status. The objective of this study was to evaluate the gonial angle, antegonial angle, and antegonial depth and to investigate their relationship to gender, age group, and dental status. Materials and Methods. A total of 1060 panoramic radiographs were evaluated: the dentulous group, 854 subjects and the edentulous group, 206 subjects. The patients were grouped into six age groups of 10-years each. Gonial angle, antegonial angle, and antegonial depth were measured from panoramic radiographs. Results and Discussion. Corelation of age with gonial angle, antegonial angle and antegonial depth was not significant. Significant difference in mandibular angle was found between males and females. Males had significantly smaller antegonial angle and greater antegonial depth than females. Significant difference was found for gonial angle, antegonial angle, and antegonial depth between right and left sides of mandible. Conclusion. Gonial angle, antegonial angle, and antegonial depth can be implicated as a forensic tool for gender determination but not suitable for age determination

  14. Comparative study of modified polypropylene nanocomposites under environment and accelerated ageing conditions

    International Nuclear Information System (INIS)

    Komatsu, Luiz Gustavo Hiroki

    2016-01-01

    The understanding of degradation mechanism action on the polymer nanocomposites in face of weathering (UV light, heat, acid rain, among others), is the key for development of new additives and new applications. In this work the nanocomposite synthesis was carried in molten state, using twin-screw extruder. The polymer matrix was the HMS-PP (high melt polypropylene) synthesized by gamma irradiation and the nanometric inorganic component was the montmorillonite clay. For better compatibilization between the matrix and clay, it were used maleic anhydride as coupling agent. For environment and in oven accelerated aging assays, the dumbbell samples were prepared under hot pressing. The characterization of clay addition effects and aging effects on the nanocomposites, required the use of techniques of Differential Scanning Calorimetry (DSC), Thermogravimetry (TGA), Fourier Transformed Infrared Spectroscopy (FT-IR), Xray Fluorescence (WDXRF), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS) and mechanical properties. Samples with 0.1; 1; 3; 5; 10 % of clay were tested. The sample with 5% of clay showed better stability on the environmental assay and accelerated aging in oven assay. On the other hand, the sample with higher percent of clay (10%), was more degraded under on environmental aging than under accelerated aging in stove. In this case, became more resistant until 56 days of assay. On the studied concentrations (less than ≤ 3%) of clay, it can be seen an equilibrium between barrier effect and metallic ions action accelerating the degradative process. (author)

  15. Electron microscopic radioautographic studies on macromolecular synthesis in mitochondria of animal cells in aging

    Energy Technology Data Exchange (ETDEWEB)

    Nagata, Tetsuji, E-mail: nagata@kowagakuen.ac.j [Shinshu Univ. School of Medicine, Matsumoto (Japan). Dept. of Anatomy and Cell Biology

    2010-07-01

    Study aging changes of intramitochondrial DNA, RNA, protein synthesis of mouse organs during the development and aging, 30 groups of developing and aging mice (3 individuals each), from fetal day 19 to postnatal newborn at day 1, 3, 9, 14 and adult at month 1, 2, 6, 12 to 24, were injected with either {sup 3}H-thymidine, {sup 3}H-uriidine, or {sup 3}H-leucine, sacrificed 1 h later and liver, adrenal, lung and testis tissues observed by electron microscopic radioautography. Accordingly, numbers of mitochondria per cell profile area, numbers of labeled mitochondria and the mitochondrial labeling index labeled with {sup 3}H-labeled precursors showing DNA, RNA, protein synthesis in these cells (hepatocytes, 3 zones of the adrenal cortices - zona glomerulosa, fasciculata and reticularis -, adrenal medullary cells, pulmonary cells and testis cells) were counted per cells and compared among the respective developing and aging groups. The numbers of mitochondria in these cells increased from fetal day 19 to postnatal month 1 and 2. However, the numbers of labeled mitochondria and the labeling indices of intramitochondrial DNA, RNA, protein syntheses incorporating the {sup 3}H-labeled precursors in the described tissue cells increased from fetal day 19 to postnatal month 1 and decreased to month 24. These data support that the activity of intramitochnodrial DNA, RNA, protein syntheses in cells of these tissues increased and decreased by development and aging in mice. The intramitochondrial DNA, RNA and protein syntheses in some other organs were also reviewed and discussed. (author)

  16. Morphometric study on age-dependent pulmonary lesions in rats exposed to nitrogen dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Kyono, H.; Kawai, K.

    1982-01-01

    Electronmicroscopic morphometry was performed on lung of 1, 3, 12 and 21 months-old rats exposed to 0.1, 0.5, 3 and 10 ppm nitrogen dioxide (NO/sub 2/) continuously for one month. The rats used in this experiment were all supplied at one time from one colony and kept under a barrier system until exposure. Effects of aging on the responses of lungs to NO/sub 2/ were studied by comparing the dose-effect reaction patterns among the age groups. A trend of dose-dependent increase of arithmetic mean thickness of air-blood barrier was found in all age groups examined. The response of lung to NO/sub 2/ exposure showed age-related differences. Based on the morphometric index, the response declines from 1 to 12 months, but increases again in 21-months-old rats. The compartmental components of alveolar wall tissue such as type I epithelial cells, type II epithelial cells, interstitial cells, interstitial matrix and capillary endothelium appeared to have various degrees of response due to both age at onset of exposure and NO/sub 2/ concentration, resulting in the appearance of varying stages in impairment or repair. Accordingly, the response of each compartmental component of lung to the concentrations of NO/sub 2/ did not always exhibit a simple dose-dependent increase or decrease but sometimes indicated a multiphasic reaction pattern.

  17. Estimation of sex and age of 'virtual skeletons'-a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Grabherr, Silke [University Hospital of Lausanne, Institute of Forensic Medicine, Lausanne (Switzerland)]|[University of Bern, Institute of Forensic Medicine, Bern (Switzerland)]|[University Hospital of Lausanne, Service of Diagnostic and Interventional Radiology, Lausanne (Switzerland); Cooper, Christine; Ulrich-Bochsler, Susi [University of Bern, Institute for the History of Medicine, Historical Anthropology, Bern (Switzerland); Uldin, Tanya [Service of Osteo-Archaeology, Aesch (Switzerland); Ross, Steffen; Oesterhelweg, Lars; Bolliger, Stephan; Thali, Michael J. [University of Bern, Institute of Forensic Medicine, Bern (Switzerland); Christe, Andreas [University of Bern, Institute of Forensic Medicine, Bern (Switzerland)]|[University of Bern, Institute of Diagnostic Radiology, Bern (Switzerland); Schnyder, Pierre [University Hospital of Lausanne, Service of Diagnostic and Interventional Radiology, Lausanne (Switzerland); Mangin, Patrice [University Hospital of Lausanne, Institute of Forensic Medicine, Lausanne (Switzerland)

    2009-02-15

    This article presents a feasibility study with the objective of investigating the potential of multi-detector computed tomography (MDCT) to estimate the bone age and sex of deceased persons. To obtain virtual skeletons, the bodies of 22 deceased persons with known age at death were scanned by MDCT using a special protocol that consisted of high-resolution imaging of the skull, shoulder girdle (including the upper half of the humeri), the symphysis pubis and the upper halves of the femora. Bone and soft-tissue reconstructions were performed in two and three dimensions. The resulting data were investigated by three anthropologists with different professional experience. Sex was determined by investigating three-dimensional models of the skull and pelvis. As a basic orientation for the age estimation, the complex method according to Nemeskeri and co-workers was applied. The final estimation was effected using additional parameters like the state of dentition, degeneration of the spine, etc., which where chosen individually by the three observers according to their experience. The results of the study show that the estimation of sex and age is possible by the use of MDCT. Virtual skeletons present an ideal collection for anthropological studies, because they are obtained in a non-invasive way and can be investigated ad infinitum. (orig.)

  18. Age-specific association of migraine with cryptogenic TIA and stroke: Population-based study.

    Science.gov (United States)

    Li, Linxin; Schulz, Ursula G; Kuker, Wilhelm; Rothwell, Peter M

    2015-10-27

    To determine whether there is an association between previous migraine and cryptogenic TIA or ischemic stroke at older ages. We determined the age-specific associations of history of migraine and Trial of Org 10172 in Acute Stroke Treatment (TOAST) subtype of TIA and ischemic stroke in a population-based cohort study (Oxford Vascular Study; 2002-2012). Among 1,810 eligible patients with TIA or ischemic stroke, 668 (36.9%) had cryptogenic events, of whom 187 (28.0%) had previous migraine. Migraine was more commonly associated with cryptogenic events than with those of known etiology (odds ratio [OR] 1.73, 95% confidence interval [CI] 1.38-2.16, p TIA or stratified by sex or vascular territory of event. In this population-based study of stroke etiology stratified by age, migraine was most strongly associated with cryptogenic TIA and ischemic stroke, particularly at older ages, suggesting a causal role or a shared etiology. © 2015 American Academy of Neurology.

  19. Estimation of sex and age of ''virtual skeletons''-a feasibility study

    International Nuclear Information System (INIS)

    Grabherr, Silke; Cooper, Christine; Ulrich-Bochsler, Susi; Uldin, Tanya; Ross, Steffen; Oesterhelweg, Lars; Bolliger, Stephan; Thali, Michael J.; Christe, Andreas; Schnyder, Pierre; Mangin, Patrice

    2009-01-01

    This article presents a feasibility study with the objective of investigating the potential of multi-detector computed tomography (MDCT) to estimate the bone age and sex of deceased persons. To obtain virtual skeletons, the bodies of 22 deceased persons with known age at death were scanned by MDCT using a special protocol that consisted of high-resolution imaging of the skull, shoulder girdle (including the upper half of the humeri), the symphysis pubis and the upper halves of the femora. Bone and soft-tissue reconstructions were performed in two and three dimensions. The resulting data were investigated by three anthropologists with different professional experience. Sex was determined by investigating three-dimensional models of the skull and pelvis. As a basic orientation for the age estimation, the complex method according to Nemeskeri and co-workers was applied. The final estimation was effected using additional parameters like the state of dentition, degeneration of the spine, etc., which where chosen individually by the three observers according to their experience. The results of the study show that the estimation of sex and age is possible by the use of MDCT. Virtual skeletons present an ideal collection for anthropological studies, because they are obtained in a non-invasive way and can be investigated ad infinitum. (orig.)

  20. Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study.

    Science.gov (United States)

    Horvat, Pia; Gardiner, Julian; Kubinova, Ruzena; Pajak, Andrzej; Tamosiunas, Abdonas; Schöttker, Ben; Pikhart, Hynek; Peasey, Anne; Jansen, Eugene; Bobak, Martin

    2016-04-01

    Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related to cognitive ageing but epidemiological evidence remains inconclusive. The aim of this study was to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function in middle-aged and older adults from three Central and Eastern European populations. Men and women aged 45-69 at baseline participating in the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study were recruited in Krakow (Poland), Kaunas (Lithuania) and six urban centres in the Czech Republic. Tests of immediate and delayed recall, verbal fluency and letter search were administered at baseline and repeated in 2006-2008. Serum concentrations of biomarkers at baseline were measured in a sub-sample of participants. Associations of vitamin quartiles with baseline (n=4166) and follow-up (n=2739) cognitive domain-specific z-scores were estimated using multiple linear regression. After adjusting for confounders, folate was positively associated with letter search and vitamin B-12 with word recall in cross-sectional analyses. In prospective analyses, participants in the highest quartile of folate had higher verbal fluency (pcognitive domains in older Central and Eastern Europeans. These findings do not lend unequivocal support to potential importance of folate and vitamin B-12 status for cognitive function in older age. Long-term longitudinal studies and randomised trials are required before drawing conclusions on the role of these vitamins in cognitive decline. Copyright © 2016. Published by Elsevier Inc.

  1. Targeting Aging with Functional Food: Pasta with Opuntia Single-Arm Pilot Study.

    Science.gov (United States)

    Aiello, Anna; Di Bona, Danilo; Candore, Giuseppina; Carru, Ciriaco; Zinellu, Angelo; Di Miceli, Giuseppe; Nicosia, Aldo; Gambino, Caterina Maria; Ruisi, Paolo; Caruso, Calogero; Vasto, Sonya; Accardi, Giulia

    2018-06-01

    Interventions to extend life span represent the new perspective in aging investigation. Healthy dietary habits are important modifiable factors that can favor a healthy aging phenotype. Many studies have demonstrated benefits for metabolic syndrome and type 2 diabetes mellitus resulting from the traditional Mediterranean foods. Opuntia Ficus Indica (OFI), widespread in the Mediterranean basin, belongs to the Cactaceae family. It is known for its antioxidant and anti-inflammatory properties. Moreover, products containing extracts from OFI fruits or cladodes have been used to control obesity and other metabolic parameters, such as glycemia and lipid profile. The aim of this study was to analyze the antioxidant and anti-inflammatory effect of pasta with 3% of OFI cladode extracts added to show its beneficial effect in human health. We performed a single arm longitudinal intervention study