WorldWideScience

Sample records for group direct observation

  1. Working Group 1: Observations

    International Nuclear Information System (INIS)

    Trenberth, K.; Angell, J.; Barry, R.; Bradley, R.; Diaz, H.; Elliott, W.; Etkins, R.; Folland, C.; Jenne, R.; Jones, P.; Karl, T.; Levitus, S.; Oort, A.; Parker, D.; Ropelewski, C.; Vinnikov, K.; Wigley, T.

    1991-01-01

    Topics of discussion include the following: the need for observations; issues in establishing global climate trends; climate variables such as surface air temperature over land, marine temperature, precipitation, circulation, upper air measurements, historical observations, subsurface ocean data, sea level, cryosphere, clouds, solar radiation, and aerosols; future considerations and recommendations which focuses on the establishment of a global benchmark climate monitoring network and data management

  2. Working Group 1: Observations

    International Nuclear Information System (INIS)

    Trenberth, K.; Angell, J.; Barry, R.; Bradley, R.; Diaz, H.; Elliott, W.; Etkins, R.; Folland, C.; Jenne, R.; Jones, P.; Karl, T.; Levitus, S.; Oort, A.; Parker, D.; Ropelewski, C.; Vinnikov, K.; Wigley, T.

    1990-01-01

    Topics of discussion include the following: the need for observations; issues in establishing global climate trends; climate variables such as surface air temperature over land, marine temperature, precipitation, circulation, upper air measurements, historical observations, subsurface ocean data, sea level, cryosphere, clouds, solar radiation, and aerosols; future considerations and recommendations which focuses on the establishment of a global benchmark climate monitoring network and data management

  3. Direct Bandgap Group IV Materials

    Science.gov (United States)

    2016-01-21

    AFRL-AFOSR-JP-TR-2017-0049 Direct Bandgap group IV Materials Hung Hsiang Cheng NATIONAL TAIWAN UNIVERSITY Final Report 01/21/2016 DISTRIBUTION A...NAME(S) AND ADDRESS(ES) NATIONAL TAIWAN UNIVERSITY 1 ROOSEVELT RD. SEC. 4 TAIPEI CITY, 10617 TW 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING...14. ABSTRACT Direct bandgap group IV materials have been long sought for in both academia and industry for the implementation of photonic devices

  4. Directed ortho-Lithiation: Observation of an Unexpected 1-Lithio to 3-Lithio Conversion of 1-Lithio-naphthyllithium Compounds with an ortho-Directing 2-(Dimethylamino)methyl Group

    NARCIS (Netherlands)

    Jastrzebski, J.T.B.H.; Arink, A.M.; Kleijn, H.; Braam, T.W.; Lutz, M.; Spek, A.L.; van Koten, G.

    2013-01-01

    Regioselectivity is an important aspect in the design of organic protocols involving Directed ortho-Lithiation (DoL) of arenes, in particular with those arenes containing heteroatom substituents as directing groups. The DoL of 2-[(dimethylamino)methyl]naphthalene (dman) that proceeds with low

  5. Directly observed therapy for treating tuberculosis

    Science.gov (United States)

    Karumbi, Jamlick; Garner, Paul

    2015-01-01

    Background Tuberculosis (TB) requires at least six months of treatment. If treatment is incomplete, patients may not be cured and drug resistance may develop. Directly Observed Therapy (DOT) is a specific strategy, endorsed by the World Health Organization, to improve adherence by requiring health workers, community volunteers or family members to observe and record patients taking each dose. Objectives To evaluate DOT compared to self-administered therapy in people on treatment for active TB or on prophylaxis to prevent active disease. We also compared the effects of different forms of DOT. Search methods We searched the following databases up to 13 January 2015: the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register of Controlled Trials (CENTRAL), published in the Cochrane Library; MEDLINE; EMBASE; LILACS and mRCT. We also checked article reference lists and contacted relevant researchers and organizations. Selection criteria Randomized controlled trials (RCTs) and quasi-RCTs comparing DOT with routine self-administration of treatment or prophylaxis at home. Data collection and analysis Two review authors independently assessed risk of bias of each included trial and extracted data. We compared interventions using risk ratios (RR) with 95% confidence intervals (CI). We used a random-effects model if meta-analysis was appropriate but heterogeneity present (I2 statistic = 50%). We assessed the quality of the evidence using the GRADE approach. Main results Eleven trials including 5662 participants met the inclusion criteria. DOT was performed by a range of people (nurses, community health workers, family members or former TB patients) in a variety of settings (clinic, the patient's home or the home of a community volunteer). DOT versus self-administered Six trials from South Africa, Thailand, Taiwan, Pakistan and Australia compared DOT with self-administered therapy for treatment. Trials included DOT at home by family members

  6. Photometric observations of nine Shakhbazian compact groups

    International Nuclear Information System (INIS)

    Tovmassian, H.M.; Tiersch, H.; Tovmassian, G.H.; Neizvestny, S.

    2010-01-01

    By observations with the 1.5m telescope at San Pedro Martir (OAN, UNAM, Mexico) the BVR magnitudes are determined for 66 member galaxies in Shakhbazian Compact Galaxy Groups ShCG 40, ShCG 176, ShCG 270, ShCG 278, ShCG 310 and ShCG 342. Three other groups were observed in two or only in one band. Seven galaxies in ShCG 298 were observed in B and R, six galaxies in ShCG 95 were observed in V and 7 galaxies in ShCG 345 were observed in V and R. The distribution of brightness of observed galaxies is determined. Signs of interaction between galaxies are detected in some groups

  7. Ergodic directional switching in mobile insect groups

    KAUST Repository

    Escudero, Carlos

    2010-07-29

    We obtain a Fokker-Planck equation describing experimental data on the collective motion of locusts. The noise is of internal origin and due to the discrete character and finite number of constituents of the swarm. The stationary probability distribution shows a rich phenomenology including nonmonotonic behavior of several order and disorder transition indicators in noise intensity. This complex behavior arises naturally as a result of the randomness in the system. Its counterintuitive character challenges standard interpretations of noise induced transitions and calls for an extension of this theory in order to capture the behavior of certain classes of biologically motivated models. Our results suggest that the collective switches of the group\\'s direction of motion might be due to a random ergodic effect and, as such, they are inherent to group formation. © 2010 The American Physical Society.

  8. Observational properties of compact groups of galaxies

    International Nuclear Information System (INIS)

    Hickson, P.

    1990-01-01

    Compact groups are small, relatively isolated, systems of galaxies with projected separations comparable to the diameters of the galaxies themselves. Two well-known examples are Stephan's Quintet (Stephan, 1877) and Seyfert's Sextet (Seyfert 1948a,b). In groups such as these, the apparent space density of galaxies approaches 10(exp 6) Mpc(sub -3), denser even than the cores of rich clusters. The apparent unlikeliness of the chance occurrence of such tight groupings lead Ambartsumyan (1958, 1975) to conclude that compact groups must be physically dense systems. This view is supported by clear signs of galaxy interactions that are seen in many groups. Spectroscopic observations reveal that typical relative velocities of galaxies in the groups are comparable to their internal stellar velocities. This should be conducive to strong gravitational interactions - more so than in rich clusters, where galaxy velocities are typically much higher. This suggests that compact groups could be excellent laboratories in which to study galaxy interactions and their effects. Compact groups often contain one or more galaxies whose redshift differs greatly from those of the other group members. If these galaxies are at the same distance as the other members, either entire galaxies are being ejected at high velocities from these groups, or some new physical phenomena must be occurring. If their redshifts are cosmological, we must explain why so many discordant galaxies are found in compact groups. In recent years much progress has been made in addressing these questions. Here, the author discusses the current observational data on compact groups and their implications

  9. Directly observed therapy for treating tuberculosis

    OpenAIRE

    Karumbi, Jamlick; Garner, Paul

    2015-01-01

    Background Tuberculosis (TB) requires at least six months of treatment. If treatment is incomplete, patients may not be cured and drug resistance may develop. Directly Observed Therapy (DOT) is a specific strategy, endorsed by the World Health Organization, to improve adherence by requiring health workers, community volunteers or family members to observe and record patients taking each dose. Objectives To evaluate DOT compared to self-administered therapy in people on treatment for active TB...

  10. Direct gauging of the Poincare group

    International Nuclear Information System (INIS)

    Edelen, D.G.B.

    1985-01-01

    The problem of gauging matter fields with a Poincare invariant action functional that admits an r parameter, semisimple group G(r) of internal symmetries is considered. A minimal replacement operator for the total group P 10 xG(r) is obtained, together with the requisite compensating 1-forms for both the Poincare and the G(r) sectors. A basis for P 10 xG(r)-invariant Lagrangian densities for the free fields is obtained. Restriction to Lagrangian densities that are at most quadratic in the associated curvature and torsion fields eliminates active coupling between the P 10 free field Lagrangian and the G(r) free field Lagrangian, although there is passive coupling that arises through the requirement of tensorial covariance under general coordinate transformations generated by the local action of the translation group. A superposition principle, modulo passive coupling, thus holds for quadratic free field Lagrangian for the total group: Lsub(TOT)=Lsub(p)+Lsub(G(r)). Field equations for the matter fields and the compensating fields of the G(r) sector are obtained. Both share the passive coupling to P 10 that is required in order to achieve ''tensorial'' covariance, but only the matter fields couple directly to the Poincare fields and only to the Lorentz sector. For ''weak'' Poincare fields, the field equations for the matter fields and the compensating fields of the internal symmetries go over into the standard field equations of gauge theory for an internal symmetry group. (author)

  11. Ergodic directional switching in mobile insect groups

    KAUST Repository

    Escudero, Carlos; Yates, Christian A.; Buhl, Jerome; Couzin, Iain D.; Erban, Radek; Kevrekidis, Ioannis G.; Maini, Philip K.

    2010-01-01

    We obtain a Fokker-Planck equation describing experimental data on the collective motion of locusts. The noise is of internal origin and due to the discrete character and finite number of constituents of the swarm. The stationary probability distribution shows a rich phenomenology including nonmonotonic behavior of several order and disorder transition indicators in noise intensity. This complex behavior arises naturally as a result of the randomness in the system. Its counterintuitive character challenges standard interpretations of noise induced transitions and calls for an extension of this theory in order to capture the behavior of certain classes of biologically motivated models. Our results suggest that the collective switches of the group's direction of motion might be due to a random ergodic effect and, as such, they are inherent to group formation. © 2010 The American Physical Society.

  12. Direct observation limits on antimatter gravitation

    International Nuclear Information System (INIS)

    Fischler, Mark; Lykken, Joe; Roberts, Tom; Fermilab

    2008-01-01

    The proposed Antihydrogen Gravity experiment at Fermilab (P981) will directly measure the gravitational attraction g between antihydrogen and the Earth, with an accuracy of 1% or better. The following key question has been asked by the PAC: Is a possible 1% difference between g and g already ruled out by other evidence? This memo presents the key points of existing evidence, to answer whether such a difference is ruled out (a) on the basis of direct observational evidence; and/or (b) on the basis of indirect evidence, combined with reasoning based on strongly held theoretical assumptions. The bottom line is that there are no direct observations or measurements of gravitational asymmetry which address the antimatter sector. There is evidence which by indirect reasoning can be taken to rule out such a difference, but the analysis needed to draw that conclusion rests on models and assumptions which are in question for other reasons and are thus worth testing. There is no compelling evidence or theoretical reason to rule out such a difference at the 1% level

  13. International Space Station Earth Observations Working Group

    Science.gov (United States)

    Stefanov, William L.; Oikawa, Koki

    2015-01-01

    The multilateral Earth Observations Working Group (EOWG) was chartered in May 2012 in order to improve coordination and collaboration of Earth observing payloads, research, and applications on the International Space Station (ISS). The EOWG derives its authority from the ISS Program Science Forum, and a NASA representative serves as a permanent co-chair. A rotating co-chair position can be occupied by any of the international partners, following concurrence by the other partners; a JAXA representative is the current co-chair. Primary functions of the EOWG include, 1) the exchange of information on plans for payloads, from science and application objectives to instrument development, data collection, distribution and research; 2) recognition and facilitation of opportunities for international collaboration in order to optimize benefits from different instruments; and 3) provide a formal ISS Program interface for collection and application of remotely sensed data collected in response to natural disasters through the International Charter, Space and Major Disasters. Recent examples of EOWG activities include coordination of bilateral data sharing protocols between NASA and TsNIIMash for use of crew time and instruments in support of ATV5 reentry imaging activities; discussion of continued use and support of the Nightpod camera mount system by NASA and ESA; and review and revision of international partner contributions on Earth observations to the ISS Program Benefits to Humanity publication.

  14. Cosmic curvature tested directly from observations

    Science.gov (United States)

    Denissenya, Mikhail; Linder, Eric V.; Shafieloo, Arman

    2018-03-01

    Cosmic spatial curvature is a fundamental geometric quantity of the Universe. We investigate a model independent, geometric approach to measure spatial curvature directly from observations, without any derivatives of data. This employs strong lensing time delays and supernova distance measurements to measure the curvature itself, rather than just testing consistency with flatness. We define two curvature estimators, with differing error propagation characteristics, that can crosscheck each other, and also show how they can be used to map the curvature in redshift slices, to test constancy of curvature as required by the Robertson-Walker metric. Simulating realizations of redshift distributions and distance measurements of lenses and sources, we estimate uncertainties on the curvature enabled by next generation measurements. The results indicate that the model independent methods, using only geometry without assuming forms for the energy density constituents, can determine the curvature at the ~6×10‑3 level.

  15. WMAP haze: Directly observing dark matter?

    International Nuclear Information System (INIS)

    Forbes, Michael McNeil; Zhitnitsky, Ariel R.

    2008-01-01

    In this paper, we show that dark matter in the form of dense matter/antimatter nuggets could provide a natural and unified explanation for several distinct bands of diffuse radiation from the core of the Galaxy spanning over 13 orders of magnitude in frequency. We fix all of the phenomenological properties of this model by matching to x-ray observations in the keV band, and then calculate the unambiguously predicted thermal emission in the microwave band, at frequencies smaller by 11 orders of magnitude. Remarkably, the intensity and spectrum of the emitted thermal radiation are consistent with - and could entirely explain - the so-called 'WMAP haze': a diffuse microwave excess observed from the core of our Galaxy by the Wilkinson Microwave Anisotropy Probe (WMAP). This provides another strong constraint of our proposal, and a remarkable nontrivial validation. If correct, our proposal identifies the nature of the dark matter, explains baryogenesis, and provides a means to directly probe the matter distribution in our Galaxy by analyzing several different types of diffuse emissions.

  16. Me against we: in-group transgression, collective shame, and in-group-directed hostility.

    Science.gov (United States)

    Piff, Paul K; Martinez, Andres G; Keltner, Dacher

    2012-01-01

    People can experience great distress when a group to which they belong (in-group) is perceived to have committed an immoral act. We hypothesised that people would direct hostility toward a transgressing in-group whose actions threaten their self-image and evoke collective shame. Consistent with this theorising, three studies found that reminders of in-group transgression provoked several expressions of in-group-directed hostility, including in-group-directed hostile emotion (Studies 1 and 2), in-group-directed derogation (Study 2), and in-group-directed punishment (Study 3). Across studies, collective shame-but not the related group-based emotion collective guilt-mediated the relationship between in-group transgression and in-group-directed hostility. Implications for group-based emotion, social identity, and group behaviour are discussed.

  17. Direct observation of nanowire growth and decomposition

    DEFF Research Database (Denmark)

    Rackauskas, Simas; Shandakov, Sergey D; Jiang, Hua

    2017-01-01

    knowledge, so far this has been only postulated, but never observed at the atomic level. By means of in situ environmental transmission electron microscopy we monitored and examined the atomic layer transformation at the conditions of the crystal growth and its decomposition using CuO nanowires selected...

  18. Direct observation of ballistic Andreev reflection

    Science.gov (United States)

    Klapwijk, T. M.; Ryabchun, S. A.

    2014-12-01

    An overview is presented of experiments on ballistic electrical transport in inhomogeneous superconducting systems which are controlled by the process of Andreev reflection. The initial experiments based on the coexistence of a normal phase and a superconducting phase in the intermediate state led to the concept itself. It was followed by a focus on geometrically inhomogeneous systems like point contacts, which provided a very clear manifestation of the energy and direction dependence of the Andreev reflection process. The point contacts have recently evolved towards the atomic scale owing to the use of mechanical break-junctions, revealing a very detailed dependence of Andreev reflection on the macroscopic phase of the superconducting state. In present-day research, the superconducting in homogeneity is constructed by clean room technology and combines superconducting materials, for example, with low-dimensional materials and topological insulators. Alternatively, the superconductor is combined with nano-objects, such as graphene, carbon nanotubes, or semiconducting nanowires. Each of these "inhomogeneous systems" provides a very interesting range of properties, all rooted in some manifestation of Andreev reflection.

  19. Direction: happiness : improving well-being of vulnerable groups

    NARCIS (Netherlands)

    Weiss, Laura Anne

    2016-01-01

    In the PhD-thesis ‘Direction: Happiness. Improving well-being of vulnerable groups’, the effects of the Happiness Route, a positive psychology intervention, were examined. The intervention is directed at a vulnerable group with an accumulation of risk factors for a low well-being; lonely people with

  20. Direct observation of rectified motion of vortices by Lorentz microscopy

    Indian Academy of Sciences (India)

    We have investigated the vortex dynamics for the `ratchet' operation in a niobium superconductor via a direct imaging of Lorentz microscopy. We directly observe one-directional selective motion of field-gradient-driven vortices along fabricated channels. This results from the rectification of vortices in a spatially asymmetric ...

  1. Direct Observation vs. Video-Based Assessment in Flexible Cystoscopy

    DEFF Research Database (Denmark)

    Dagnaes-Hansen, Julia; Mahmood, Oria; Bube, Sarah

    2018-01-01

    .86. Interrater reliability was 0.74 for single measure and 0.85 for average measures. A hawk-dove effect was seen between the 2 raters. Direct observer bias was detected when comparing direct observer scores to the assessment by an independent video-rater (p

  2. The Impact of Process Observers on Interpersonal Group Therapy

    Science.gov (United States)

    Hogan, Christopher; Harris, Rafael S.; Cassidy, Jennie M.

    2006-01-01

    The impact of including process observers (all master's-level trainees) and their notes on the outcome of interpersonal group therapy at a university counseling center was investigated. For a total of four groups, one method per group of delivering the notes to the participants was designated and assessed for perceived differences. A self-report…

  3. Observations of Student Behavior in Collaborative Learning Groups

    Science.gov (United States)

    Adams, Jeffrey P.; Brissenden, Gina; Lindell, Rebecca S.; Slater, Timothy F.; Wallace, Joy

    In an effort to determine how our students were responding to the use of collaborative learning groups in our large enrollment introductory astronomy (ASTRO 101) courses, we systematically observed the behavior of 270 undergraduate students working in 48 self-formed groups. Their observed behaviors were classified as: (i) actively engaged; (ii) watching actively; (iii) watching passively; and (iv) disengaged. We found that male behavior is consistent regardless of the sex-composition of the groups. However, females were categorized as watching passively and or disengaged significantly more frequently when working in groups that contained uneven numbers of males and females. This case study observation suggests that faculty who use collaborative learning groups might find that the level of student participation in collaborative group learning activities can depend on the sex-composition of the group.

  4. Quality of life among dots (directly observed treatment short course ...

    African Journals Online (AJOL)

    Quality of life among dots (directly observed treatment short course) cured patients: ... which is a specific instrument and covers four domains of health i.e. physical, ... thereby necessitating measures for the improvement of the overall health of ...

  5. Directly Observed Treatment Short Course (DOTS) appears to have ...

    African Journals Online (AJOL)

    Directly Observed Treatment Short Course (DOTS) appears to have reduced the self-care role of pulmonary tuberculosis patient: evidence from a correctional study between Personal Health Beliefs (PHB) and Self Care Practices (SCP)

  6. Evolution of group-wise cooperation: Is direct reciprocity insufficient?

    Science.gov (United States)

    Kurokawa, Shun; Ihara, Yasuo

    2017-02-21

    Group-wise cooperation, or cooperation among three or more individuals, is an integral part of human societies. It is likely that group-wise cooperation also played a crucial role in the survival of early hominins, who were confronted with novel environmental challenges, long before the emergence of Homo sapiens. However, previous theoretical and empirical studies, focusing mainly on modern humans, have tended to suggest that evolution of cooperation in sizable groups cannot be explained by simple direct reciprocity and requires some additional mechanisms (reputation, punishment, etc.), which are cognitively too demanding for early hominins. As a partial resolution of the paradox, our recent analysis of a stochastic evolutionary model, which considers the effect of random drift, has revealed that evolution of group-wise cooperation is more likely to occur in larger groups when an individual's share of the benefit produced by one cooperator does not decrease with increasing group size (i.e., goods are non-rivalrous). In this paper, we further extend our previous analysis to explore possible consequences of introducing rare mistakes in behavior or imperfect information about behavior of others on the model outcome. Analyses of the extended models show that evolution of group-wise cooperation can be facilitated by large group size even when individuals intending to cooperate sometimes fail to do so or when all the information about the past behavior of group members is not available. We argue, therefore, that evolution of cooperation in sizable groups does not necessarily require other mechanisms than direct reciprocity if the goods to be produced via group-wise cooperation are non-rivalrous. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Directional effects in transitional resonance spectra and group constants

    International Nuclear Information System (INIS)

    Hill, R.N.; Oh, K.O.; Rhodes, J.D.

    1989-01-01

    Analytical exploratory investigations indicate that transition effects such as streaming cause a considerable spatial variation in the neutron spectra across resonances; streaming leads to opposite effects in the forward and backward directions. The neglect of this coupled spatial/angular variations of the transitory resonance spectra is an approximation that is common to all current group constant generation methodologies. This paper presents a description of the spatial/angular coupling of the neutron flux across isolated resonances. It appears to be necessary to differentiate between forward-and backward-directed neutron flux components or even to consider components in narrower angular cones. The effects are illustrated for an isolated actinide resonance in a simplified fast reactor blanket problem. The resonance spectra of the directional flux components φ + and φ - , and even more so the 90-deg cone components, are shown to deviate significantly from the infinite medium approximation, and the differences increase with penetration. The charges in φ + lead to a decreasing scattering group constant that enhances neutron transmission; the changes in φ - lead to an increasing group constant inhibiting backward scattering. Therefore, the changes in the forward-and backward-directed spectra both lead to increased neutron transmission. Conversely, the flux (φ = φ + +φ - ) is shown to agree closely with the infinite medium approximation both in the analytical formulas and in the numerical solution. The directional effect cancel in the summation. The forward-and backward-directed flux components are used as weighting spectra to illustrate the group constant changes for a single resonance

  8. Flattening the organization: implementing self-directed work groups.

    Science.gov (United States)

    Brandon, G M

    1996-01-01

    In response to tremendous growth of managed care and threats to financial stability and job security, the Greater Baltimore Medical Center (GBMC) restructured itself into independent business units. The radiology department at GBMC resolved to reduce cost per unit-of-service, improve service, determine optimal staffing levels and reduce the number of layers of organization. It was decided to achieve those goals by implementing self-directed work groups. Staff buy-in was critical to success of the project. To begin, the staff was educated intensively about current trends in healthcare, managed care and potential changes in the job market. The radiology department was allowed to reduce the size of its staff through attrition and worked hard to focus staff concern on the impact each individual could have on the bottom line and the resultant effect on job security. Self-directed work groups were designed on a matrix that used small "service teams" in combinations to form larger "work groups." Actual work and daily activities occur at the service team level; information exchange and major decisions occue at the work group level. Seventeen months after beginning the project and 10 months after implementation, the organization has flattened, staff members have adjusted well to new roles, there have been no lay-offs, and the matrix system of small and large groups have proved particularly valuable.

  9. Automated Ecological Assessment of Physical Activity: Advancing Direct Observation.

    Science.gov (United States)

    Carlson, Jordan A; Liu, Bo; Sallis, James F; Kerr, Jacqueline; Hipp, J Aaron; Staggs, Vincent S; Papa, Amy; Dean, Kelsey; Vasconcelos, Nuno M

    2017-12-01

    Technological advances provide opportunities for automating direct observations of physical activity, which allow for continuous monitoring and feedback. This pilot study evaluated the initial validity of computer vision algorithms for ecological assessment of physical activity. The sample comprised 6630 seconds per camera (three cameras in total) of video capturing up to nine participants engaged in sitting, standing, walking, and jogging in an open outdoor space while wearing accelerometers. Computer vision algorithms were developed to assess the number and proportion of people in sedentary, light, moderate, and vigorous activity, and group-based metabolic equivalents of tasks (MET)-minutes. Means and standard deviations (SD) of bias/difference values, and intraclass correlation coefficients (ICC) assessed the criterion validity compared to accelerometry separately for each camera. The number and proportion of participants sedentary and in moderate-to-vigorous physical activity (MVPA) had small biases (within 20% of the criterion mean) and the ICCs were excellent (0.82-0.98). Total MET-minutes were slightly underestimated by 9.3-17.1% and the ICCs were good (0.68-0.79). The standard deviations of the bias estimates were moderate-to-large relative to the means. The computer vision algorithms appeared to have acceptable sample-level validity (i.e., across a sample of time intervals) and are promising for automated ecological assessment of activity in open outdoor settings, but further development and testing is needed before such tools can be used in a diverse range of settings.

  10. Directing-Group-mediated C-H-Alkynylations.

    Science.gov (United States)

    Caspers, Lucien D; Nachtsheim, Boris J

    2018-05-18

    C-C triple bonds are amongst the most versatile functional groups in synthetic chemistry. Complementary to the Sonogashira coupling the direct metal-catalyzed alkynylation of C-H bonds has emerged as a highly promising approach in recent years. To guarantee a high regioselectivity suitable directing groups (DGs) are necessary to guide the transition metal (TM) into the right place. In this Focus Review we present the current developments in DG-mediated C(sp 2 )-H and C(sp 3 )-H modifications with terminal alkynes under oxidative conditions and with electrophilic alkynylation reagents. We will discuss further modifications of the alkyne, in particular subsequent cyclizations to carbo- and heterocycles and modifications of the DG in the presence of the alkyne. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Direct observation of OH production from the ozonolysis of olefins

    Science.gov (United States)

    Donahue, Neil M.; Kroll, Jesse H.; Anderson, James G.; Demerjian, Kenneth L.

    Ozone olefin reactions may be a significant source of OH in the urban atmosphere, but current evidence for OH production is indirect and contested. We report the first direct observation of OH radicals from the reaction of ozone with a series of olefins (ethene, isoprene, trans-2-butene and 2,3 dimethyl-2-butene) in 4-6 torr of nitrogen. Using LIF to directly observe the steady-state of OH produced by the initial ozone-olefin reaction and subsequently destroyed by the OH-olefin reaction, we are able to establish OH yields broadly consistent with indirect values. The identification of the OH is unequivocal, and there is no indication that it is produced by a secondary process. To support these observations, we present a complete ab-initio potential energy surface for the O3-ethene reaction, extending from the reactants to available products.

  12. Automated Ecological Assessment of Physical Activity: Advancing Direct Observation

    Directory of Open Access Journals (Sweden)

    Jordan A. Carlson

    2017-12-01

    Full Text Available Technological advances provide opportunities for automating direct observations of physical activity, which allow for continuous monitoring and feedback. This pilot study evaluated the initial validity of computer vision algorithms for ecological assessment of physical activity. The sample comprised 6630 seconds per camera (three cameras in total of video capturing up to nine participants engaged in sitting, standing, walking, and jogging in an open outdoor space while wearing accelerometers. Computer vision algorithms were developed to assess the number and proportion of people in sedentary, light, moderate, and vigorous activity, and group-based metabolic equivalents of tasks (MET-minutes. Means and standard deviations (SD of bias/difference values, and intraclass correlation coefficients (ICC assessed the criterion validity compared to accelerometry separately for each camera. The number and proportion of participants sedentary and in moderate-to-vigorous physical activity (MVPA had small biases (within 20% of the criterion mean and the ICCs were excellent (0.82–0.98. Total MET-minutes were slightly underestimated by 9.3–17.1% and the ICCs were good (0.68–0.79. The standard deviations of the bias estimates were moderate-to-large relative to the means. The computer vision algorithms appeared to have acceptable sample-level validity (i.e., across a sample of time intervals and are promising for automated ecological assessment of activity in open outdoor settings, but further development and testing is needed before such tools can be used in a diverse range of settings.

  13. Direct observations of blob deformation during a substorm

    Directory of Open Access Journals (Sweden)

    T. Ishida

    2015-05-01

    Full Text Available Ionospheric blobs are localized plasma density enhancements, which are mainly produced by the transportation process of plasma. To understand the deformation process of a blob, observations of plasma parameters with good spatial–temporal resolution are desirable. Thus, we conducted the European Incoherent Scatter radar observations with high-speed meridional scans (60–80 s during October and December 2013, and observed the temporal evolution of a blob during a substorm on 4 December 2013. This paper is the first report of direct observations of blob deformation during a substorm. The blob deformation arose from an enhanced plasma flow shear during the substorm expansion phase, and then the blob split into two smaller-scale blobs, whose scale sizes were more than ~100 km in latitude. Our analysis indicates that the Kelvin–Helmholtz instability and dissociative recombination could have deformed the blob structure.

  14. An attempt to observe directly beauty particles in nuclear emulsions

    International Nuclear Information System (INIS)

    Albanese, J.P.; Arnold, R.; Matteuzzi, C.; Musset, P.; Piuz, F.; Poulard, G.; Price, M.J.; Ramello, L.; Sletten, H.; Allasia, D.; Bisi, V.; Gamba, D.; Marzari-Chiesa, A.; Riccati, L.; Romero, A.; Armenise, N.; Calicchio, M.; Erriquez, O.; Lavopa, P.; Maggi, G.; Muciaccia, M.T.; Natali, S.; Nuzzo, S.; Romano, F.; Ruggieri, F.; Baroni, G.; Di Ciaccio, L.; Di Liberto, S.; Manfredini, A.; Meddi, F.; Petrera, S.; Romano, G.; Rosa, G.; Santonico, R.; Sebastiani, F.; Barth, M.; Bertrand, D.; Bertrand-Coremans, G.; Roosen, R.; Sacton, J.; Schorochoff, G.; Wickens, J.; Breslin, A.C.; Montwill, A.; O'Connor, A.; Davis, D.G.; Davis, D.H.; Downes, J.K.; Duff, B.G.; Esten, M.J.; Gjerpe, I.; Heymann, F.F.; Imrie, D.C.; Lush, G.J.; Tovee, D.N.; Hazama, M.; Isokane, Y.; Tsuneoka, Y.; Maeda, Y.; Tasaka, S.

    1983-01-01

    An attempt at the direct observation of the cascade decay of beauty particles, produced by π - of 350 GeV/c leading to 3 muons or 4 muons in the final state, has been made in an emulsion/counter hybrid experiment at CERN. Under the assumption that the lifetime of beauty particles is of the order of 10 - 13 s the non-observation of any candidates provides an upper limit for beauty production of approx.=90 nb at the 90% confidence level. (orig.)

  15. Direct observation during surgery shows preservation of cerebral microcirculation in patients with traumatic brain injury

    NARCIS (Netherlands)

    Pérez-Bárcena, Jon; Romay, Eduardo; Llompart-Pou, Juan Antonio; Ibáñez, Javier; Brell, Marta; Llinás, Pedro; González, Elsa; Merenda, Amedeo; Ince, Can; Bullock, Ross

    2015-01-01

    To describe the alterations of the cortical microcirculation of the brain (blood flow and vessel density) in TBI patients who and compare them with a control group. Prospective and observational study in a third-level university hospital. Cortical microcirculation in the brain was directly observed

  16. Observability of linear control systems on Lie groups

    International Nuclear Information System (INIS)

    Ayala, V.; Hacibekiroglu, A.K.

    1995-01-01

    In this paper, we study the observability problem for a linear control system Σ on a Lie group G. The drift vector field of Σ is an infinitesimal automorphism of G and the control vectors are elements in the Lie algebra of G. We establish algebraic conditions to characterize locally and globally observability for Σ. As in the linear case on R n , these conditions are independent of the control vector. We give an algorithm on the co-tangent bundle of G to calculate the equivalence class of the neutral element. (author). 6 refs

  17. Direct observation of lubricant additives using tomography techniques

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yunyun [Department of Materials Science and Engineering, Texas A& M University, College Station, Texas 77843 (United States); Sanchez, Carlos [Mechanical Engineering, Texas A& M University, College Station, Texas 77843 (United States); Parkinson, Dilworth Y. [Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Liang, Hong, E-mail: hliang@tamu.edu [Department of Materials Science and Engineering, Texas A& M University, College Station, Texas 77843 (United States); Mechanical Engineering, Texas A& M University, College Station, Texas 77843 (United States)

    2016-07-25

    Lubricants play important roles in daily activities such as driving, walking, and cooking. The current understanding of mechanisms of lubrication, particularly in mechanical systems, has been limited by the lack of capability in direct observation. Here, we report an in situ approach to directly observe the motion of additive particles in grease under the influence of shear. Using the K-edge tomography technique, it is possible to detect particular additives in a grease and observe their distribution through 3D visualization. A commercial grease as a reference was studied with and without an inorganic additive of Fe{sub 3}O{sub 4} microparticles. The results showed that it was possible to identify these particles and track their movement. Under a shear stress, Fe{sub 3}O{sub 4} particles were found to adhere to the edge of calcium complex thickeners commonly used in grease. Due to sliding, the grease formed a film with increased density. This approach enables in-line monitoring of a lubricant and future investigation in mechanisms of lubrication.

  18. Observation interventions as a means to manipulate collective efficacy in groups.

    Science.gov (United States)

    Bruton, Adam M; Mellalieu, Stephen D; Shearer, David A

    2014-02-01

    The purpose of this multistudy investigation was to examine observation as an intervention for the manipulation of individual collective efficacy beliefs. Study 1 compared the effects of positive, neutral, and negative video footage of practice trials from an obstacle course task on collective efficacy beliefs in assigned groups. The content of the observation intervention (i.e., positive, neutral, and negative video footage) significantly influenced the direction of change in collective efficacy (p team/sport vs. unfamiliar team/sport) on individual collective efficacy perceptions when observing positive footage of competitive basketball performance. Collective efficacy significantly increased for both the familiar and unfamiliar conditions postintervention, with the largest increase for the familiar condition (p individual perceptions of collective efficacy in group-based activities. The findings suggest that observations of any group displaying positive group characteristics are likely to increase collective efficacy beliefs; however, observation of one's own team leads to the greatest increases.

  19. The Group on Earth Observations (GEO) through 2025

    Science.gov (United States)

    Ryan, Barbara; Cripe, Douglas

    Ministers from the Group on Earth Observations (GEO) Member governments, meeting in Geneva, Switzerland in January 2014, unanimously renewed the mandate of GEO through 2025. Through a Ministerial Declaration, they reconfirmed that GEO’s guiding principles of collaboration in leveraging national, regional and global investments and in developing and coordinating strategies to achieve full and open access to Earth observations data and information in order to support timely and knowledge-based decision-making - are catalysts for improving the quality of life of people around the world, advancing global sustainability, and preserving the planet and its biodiversity. GEO Ministers acknowledged and valued the contributions of GEO Member governments and invited all remaining Member States of the United Nations to consider joining GEO. The Ministers also encouraged all Members to strengthen national GEO arrangements, and - of particular interest to COSPAR - they highlighted the unique contributions of Participating Organizations. In this regard, ten more organizations saw their applications approved by Plenary and joined the ranks along with COSPAR to become a Participating Organization in GEO, bringing the current total to 77. Building on the efforts of a Post-2015 Working Group, in which COSPAR participated, Ministers provided additional guidance for GEO and the evolution of its Global Earth Observation System of System (GEOSS) through 2025. Five key areas of activities for the next decade include the following: 1.) Advocating for the value of Earth observations and the need to continue improving Earth observation worldwide; 2.) Urging the adoption and implementation of data sharing principles globally; 3.) Advancing the development of the GEOSS information system for the benefit of users; 4.) Developing a comprehensive interdisciplinary knowledge base defining and documenting observations needed for all disciplines and facilitate availability and accessibility of

  20. Direct observation of ionic structure at solid-liquid interfaces

    DEFF Research Database (Denmark)

    Siretanu, Igor; Ebeling, Daniel; Andersson, Martin Peter

    2014-01-01

    The distribution of ions and charge at solid-water interfaces plays an essential role in a wide range of processes in biology, geology and technology. While theoretical models of the solid-electrolyte interface date back to the early 20th century, a detailed picture of the structure of the electric...... double layer has remained elusive, largely because of experimental techniques have not allowed direct observation of the behaviour of ions, i.e. with subnanometer resolution. We have made use of recent advances in high-resolution Atomic Force Microscopy to reveal, with atomic level precision, the ordered...

  1. Offshore Rayleigh Group Velocity Observations of the South Island, New Zealand, from Ambient Noise Data

    KAUST Repository

    Yeck, William L.; Sheehan, Anne F.; Stachnik, Joshua C.; Lin, Fan-Chi

    2017-01-01

    We present azimuthally anisotropic Rayleigh group velocity models from 8 - 35 s both offshore and onshore of the South Island of New Zealand. We use MOANA (Marine Observations of Anisotropy Near Aotearoa) broadband ocean seismic data in combination with on land data from the New Zealand National Seismography Network (NZNSN) to investigate the seismic structure of the flanks of the Australian-Pacific plate boundary. At 8 s, we observe low offshore group velocities best explained by the influence of the water layer and thick water-laden sediments. At long periods (20-30 s), group velocities are lower on the South Island relative to its offshore flanks, due to thickened crust beneath the island, with the lowest velocities primarily beneath the Southern Alps. Group velocity azimuthal anisotropy fast directions near the Alpine Fault align with the direction of relative plate motion between the Australian and Pacific plates. In the southern portion of the island, fast directions rotate anticlockwise, likely in response to a decrease in dextral shearing away from the plate boundary. Azimuthal anisotropy fast directions align with absolute plate motion offshore on the Pacific plate. Based on the depth sensitivity of our observations, we suggest diffuse deformation occurs throughout the crust. Our observations match trends in previous Pn anisotropy and SKS shear wave splitting observations, and therefore suggest a consistent pattern of distributed deformation throughout the lithosphere.

  2. Offshore Rayleigh Group Velocity Observations of the South Island, New Zealand, from Ambient Noise Data

    KAUST Repository

    Yeck, William L.

    2017-02-15

    We present azimuthally anisotropic Rayleigh group velocity models from 8 - 35 s both offshore and onshore of the South Island of New Zealand. We use MOANA (Marine Observations of Anisotropy Near Aotearoa) broadband ocean seismic data in combination with on land data from the New Zealand National Seismography Network (NZNSN) to investigate the seismic structure of the flanks of the Australian-Pacific plate boundary. At 8 s, we observe low offshore group velocities best explained by the influence of the water layer and thick water-laden sediments. At long periods (20-30 s), group velocities are lower on the South Island relative to its offshore flanks, due to thickened crust beneath the island, with the lowest velocities primarily beneath the Southern Alps. Group velocity azimuthal anisotropy fast directions near the Alpine Fault align with the direction of relative plate motion between the Australian and Pacific plates. In the southern portion of the island, fast directions rotate anticlockwise, likely in response to a decrease in dextral shearing away from the plate boundary. Azimuthal anisotropy fast directions align with absolute plate motion offshore on the Pacific plate. Based on the depth sensitivity of our observations, we suggest diffuse deformation occurs throughout the crust. Our observations match trends in previous Pn anisotropy and SKS shear wave splitting observations, and therefore suggest a consistent pattern of distributed deformation throughout the lithosphere.

  3. Direct observation of crystal texture by neutron diffraction topography

    International Nuclear Information System (INIS)

    Tomimitsu, Hiroshi

    1982-02-01

    This document reports the development and the applications of the neutron diffraction topography (NDT), which have been carried out at JAERI in these 10 years. This describes how the substructure of Cu-5%Ge single crystal of large-scale (3 cm in diameter and 10 cm in length) was revealed by the NDT-observation. It was discovered that the specimen crystal was made up from the layer-substructures parallel to (001) and to the [110] growth direction, and that each (001) layer-substructure mentioned above was further subdivided into the central thin sublayer parallel to (001) and thick plates of [100] and [010] directions, attached symmetrically to both sides of the central (001) sublayer with regular intervals. The model of the substructure described above was supported by the calculation of the diffraction intensities. The model of the layer-substructure described above, on the other hand, suggested a simple mechanism of crystal growth of the specimen. This document also reports the NDT-observation of the three-dimensional distribution of the lattice strains within a hot-pressed Ge single crystal, and the equal thickness fringes and the coherent boundaries of a twinned Si crystal. The powerfulness and the reliability of the NDT-technique were thus demonstrated. (author)

  4. Young adult smoking in peer groups: an experimental observational study.

    Science.gov (United States)

    Harakeh, Zeena; Vollebergh, Wilma A M

    2013-03-01

    The aim of this experimental observational study is to examine whether, in a group setting (same-sex triads), passive peer influence (imitation) in the context of homogeneous and heterogeneous (contradictory) behavior of peer models affects young adults' smoking behavior. An experiment was conducted among 48 daily-smoking college and university students aged 17-25. Participants had to complete a 30-min music task with two same-sex confederates. We tested the following three conditions: (a) neither of the confederates is smoking, (b) one confederate is smoking and the other is not, and (c) both confederates are smoking. The primary outcome tested was the total number of cigarettes smoked during the task. Students in the condition with two smoking peer models and in the condition with one smoking peer model and one nonsmoking peer model smoked significantly more cigarettes than those in the condition with two nonsmoking peer models. However, results for the condition with two smoking peer models did not differ significantly from the condition with one smoking peer model and one nonsmoking peer model. Our findings show that in a group setting, the impact of the homogeneity of smoking peers on young adults' smoking behavior is not greater than the impact of the heterogeneity of smoking and nonsmoking peers. This would suggest that the smoking peer in the group has a greater impact on the daily-smoking young adult, thus reducing or even eliminating the protective effect of the nonsmoking peer model.

  5. Direct observation of vibrational energy dispersal via methyl torsions.

    Science.gov (United States)

    Gardner, Adrian M; Tuttle, William D; Whalley, Laura E; Wright, Timothy G

    2018-02-28

    Explicit evidence for the role of methyl rotor levels in promoting energy dispersal is reported. A set of coupled zero-order vibration/vibration-torsion (vibtor) levels in the S 1 state of para -fluorotoluene ( p FT) are investigated. Two-dimensional laser-induced fluorescence (2D-LIF) and two-dimensional zero-kinetic-energy (2D-ZEKE) spectra are reported, and the assignment of the main features in both sets of spectra reveals that the methyl torsion is instrumental in providing a route for coupling between vibrational levels of different symmetry classes. We find that there is very localized, and selective, dissipation of energy via doorway states, and that, in addition to an increase in the density of states, a critical role of the methyl group is a relaxation of symmetry constraints compared to direct vibrational coupling.

  6. Useful technique for submucous myomectomy under direct transcervical resectoscope observation

    Directory of Open Access Journals (Sweden)

    Tatsuji Hoshino

    2017-08-01

    Full Text Available The transcervical resectoscope (TCR is used for resecting a submucous myoma (SMM. Safe grasping of an SMM with forceps and its complete resection under transabdominal ultrasound (TAUS guidance is not always easy. SMMs are slippery, making them difficult to grasp. The SMM moves right to left and anterior to posterior when the surgeon tries to grasp it with placental forceps. Surgeons could use small Martin forceps (65% smaller to grasp SMMs safely and tightly under direct TCR (transcervical resectoscope observation. We present a case in which this operative procedure was used to remove an SMM with Figure and Video. The benefits of this procedure are enormous and could be immeasurably important to hysteroscopists and gynecologists.

  7. Direct observation of thermal disorder and decomposition of black phosphorus

    Science.gov (United States)

    Yoo, Seung Jo; Kim, Heejin; Lee, Ji-Hyun; Kim, Jin-Gyu

    2018-02-01

    Theoretical research has been devoted to reveal the properties of black phosphorus as a two-dimensional nanomaterial, but little attention has been paid for the experimental characterization. In this study, the thermal disorder and decomposition of black phosphorus were examined using in situ heating transmission electron microscopy experiments. We observed that the breaking of crystallographic symmetry begins at 380 °C under vacuum condition, followed by the phosphorus evaporates after long-term heating at 400 °C. This decomposition process can be initiated by the surficial vacancy and proceeds toward both interlayer ([010]) and intralayer ([001]) directions. The results on the thermal behavior of black phosphorus provide useful guidance for thin film deposition and fabrication processes with black phosphorus.

  8. Semiquantitative bacterial observations with group B streptococcal vulvovaginitis.

    Science.gov (United States)

    Monif, G R

    1999-01-01

    OBJECTIVE: Group B streptococcal (GBS) vulvovaginitis is a poorly-delineated clinical entity. The purpose of this study is to report semiquantitative data from four cases of GBS vulvovaginitis and to comment on their significance in terms of the in vitro inhibitory capabilities of GBS. METHODOLOGY: Four patients whose clinical presentations were consistent with GBS vulvovaginitis, from whom GBS was isolated and for whom semi-quantitative as well as qualitative microbiologic data existed, were identified. RESULTS: To produce vulvovaginitis, GBS must be at a high multiplicity (10(8) CFU/g of vaginal fluid). Single coisolates were identified in three of the four cases (two cases of Escherichia coli and one case of Staphylococcus aureus). Group B streptococcus does not inhibit either of these bacteria in vitro. CONCLUSION: When the growth requirements for the demonstration of in vitro inhibition for GBS or lack thereof are met in vivo, the in vivo observations are consistent with those projected from the in vitro data. PMID:10524667

  9. Assimilation of wind speed and direction observations: results from real observation experiments

    Directory of Open Access Journals (Sweden)

    Feng Gao

    2015-06-01

    Full Text Available The assimilation of wind observations in the form of speed and direction (asm_sd by the Weather Research and Forecasting Model Data Assimilation System (WRFDA was performed using real data and employing a series of cycling assimilation experiments for a 2-week period, as a follow-up for an idealised post hoc assimilation experiment. The satellite-derived Atmospheric Motion Vectors (AMV and surface dataset in Meteorological Assimilation Data Ingest System (MADIS were assimilated. This new method takes into account the observation errors of both wind speed (spd and direction (dir, and WRFDA background quality control (BKG-QC influences the choice of wind observations, due to data conversions between (u,v and (spd, dir. The impacts of BKG-QC, as well as the new method, on the wind analysis were analysed separately. Because the dir observational errors produced by different platforms are not known or tuned well in WRFDA, a practical method, which uses similar assimilation weights in comparative trials, was employed to estimate the spd and dir observation errors. The asm_sd produces positive impacts on analyses and short-range forecasts of spd and dir with smaller root-mean-square errors than the u,v-based system. The bias of spd analysis decreases by 54.8%. These improvements result partly from BKG-QC screening of spd and dir observations in a direct way, but mainly from the independent impact of spd (dir data assimilation on spd (dir analysis, which is the primary distinction from the standard WRFDA method. The potential impacts of asm_sd on precipitation forecasts were evaluated. Results demonstrate that the asm_sd is able to indirectly improve the precipitation forecasts by improving the prediction accuracies of key wind-related factors leading to precipitation (e.g. warm moist advection and frontogenesis.

  10. Direct observation, study and control of molecular super rotors

    Science.gov (United States)

    Korobenko, Aleksey; Milner, Alexander; Hepburn, John; Milner, Valery

    2014-05-01

    Extremely fast rotating molecules whose rotational energy is comparable with or exceeds the molecular bond strength are known as ``super rotors''. It has been speculated that super rotors may exhibit a number of unique properties, yet only indirect evidence of these molecular objects has been reported to date. We demonstrate the first direct observation of molecular super rotors by detecting coherent unidirectional molecular rotation with extreme frequencies exceeding 10 THz. The technique of an ``optical centrifuge'' is used to control the degree of rotational excitation in an ultra-broad range of rotational quantum numbers, reaching as high as N = 95 in oxygen and N = 60 in nitrogen. State-resolved detection enables us to determine the shape of the excited rotational wave packet and quantify the effect of centrifugal distortion on the rotational spectrum. Femtosecond time resolution reveals coherent rotational dynamics with increasing coherence times at higher angular momentum. We demonstrate that molecular super rotors can be created and observed in dense samples under normal conditions where the effects of ultrafast rotation on many-body interactions, inter-molecular collisions and chemical reactions can be readily explored.

  11. Direct observation of the spin-dependent Peltier effect.

    Science.gov (United States)

    Flipse, J; Bakker, F L; Slachter, A; Dejene, F K; van Wees, B J

    2012-02-05

    The Peltier coefficient describes the amount of heat that is carried by an electrical current when it passes through a material. When two materials with different Peltier coefficients are placed in contact with one another, the Peltier effect causes a net flow of heat either towards or away from the interface between them. Spintronics describes the transport of electric charge and spin angular momentum by separate spin-up and spin-down channels in a device. The observation that spin-up and spin-down charge transport channels are able to transport heat independently of each other has raised the possibility that spin currents could be used to heat or cool the interface between materials with different spin-dependent Peltier coefficients. Here, we report the direct observation of the heating and cooling of such an interface by a spin current. We demonstrate this spin-dependent Peltier effect in a spin-valve pillar structure that consists of two ferromagnetic layers separated by a non-ferromagnetic metal. Using a three-dimensional finite-element model, we extract spin-dependent Peltier coefficients in the range -0.9 to -1.3 mV for permalloy. The magnetic control of heat flow could prove useful for the cooling of nanoscale electronic components or devices.

  12. Direct gauging of the Poincare group V. Group scaling, classical gauge theory, and gravitational corrections

    International Nuclear Information System (INIS)

    Edelen, D.G.B.

    1986-01-01

    Homogeneous scaling of the group space of the Poincare group, P 10 , is shown to induce scalings of all geometric quantities associated with the local action of P 10 . The field equations for both the translation and the Lorentz rotation compensating fields reduce to O(1) equations if the scaling parameter is set equal to the general relativistic gravitational coupling constant 8πGc -4 . Standard expansions of all field variables in power series in the scaling parameter give the following results. The zeroth-order field equations are exactly the classical field equations for matter fields on Minkowski space subject to local action of an internal symmetry group (classical gauge theory). The expansion process is shown to break P 10 -gauge covariance of the theory, and hence solving the zeroth-order field equations imposes an implicit system of P 10 -gauge conditions. Explicit systems of field equations are obtained for the first- and higher-order approximations. The first-order translation field equations are driven by the momentum-energy tensor of the matter and internal compensating fields in the zeroth order (classical gauge theory), while the first-order Lorentz rotation field equations are driven by the spin currents of the same classical gauge theory. Field equations for the first-order gravitational corrections to the matter fields and the gauge fields for the internal symmetry group are obtained. Direct Poincare gauge theory is thus shown to satisfy the first two of the three-part acid test of any unified field theory. Satisfaction of the third part of the test, at least for finite neighborhoods, seems probable

  13. Direct Observation of Radiation Defects: Experiment and Interpretation

    International Nuclear Information System (INIS)

    Dudarev, S.L.

    2012-01-01

    Electron microscopy is arguably the only available experimental method suitable for the direct visualization of nano-scale defect structures formed under irradiation. Images of dislocation loops and point-defect clusters in crystals are usually produced using diffraction contrast methods. For relatively large defects, a combination of dynamical imaging and image contrast simulations is required for determining the nature of visible radiation defects. At the same time, density functional theory (DFT) models developed over the last decade have provided unique information about the structure of nano-scale defects produced by irradiation, including the defects that are so small that they cannot be observed in an electron microscope, and about the pathways of migration and interaction between radiation defects. DFT models, involving no experimental input parameters and being as quantitatively accurate and informative as the most advanced experimental techniques for the direct observation of defects, have created a new paradigm for the scientific investigation of radiation damage phenomena. In particular, DFT models offer new insight into the origin of temperature-dependent response of materials to irradiation, a problem of pivotal significance for applications. By combining information derived from the first-principles models for radiation defects with information derived from small-scale experimental observations it may be possible to acquire quantitative knowledge about how materials respond to irradiation and, using this knowledge, develop materials suitable for advanced applications in fission and fusion. It now appears possible to pose the question about the development of integrated fusion power plant models, combining neutron transport calculations and microscopic models for microstructural evolution of materials, for example models for ab initio prediction of helium embrittlement. Such models, based on scientific principles and quantitative data, and developed

  14. Direct observation of hematopoietic progenitor chimerism in fetal freemartin cattle

    Directory of Open Access Journals (Sweden)

    Taponen Juhani

    2007-11-01

    Full Text Available Abstract Background Cattle twins are well known as blood chimeras. However, chimerism in the actual hematopoietic progenitor compartment has not been directly investigated. Here, we analyzed fetal liver of chimeric freemartin cattle by combining a new anti-bovine CD34 antibody and Y-chromosome specific in situ hybridization. Results Bull-derived CD34+ cells were detected in the liver of the female sibling (freemartin at 60 days gestation. The level of bull-derived CD34+ cells was lower in the freemartin than in its male siblings. Bull (Y+ and cow hematopoietic cells often occurred in separate clusters. Around clusters of Y+CD34+ cells, Y+CD34- cells were typically observed. The thymi were also strongly chimeric at 60 days of gestation. Conclusion The fetal freemartin liver contains clusters of bull-derived hematopoietic progenitors, suggesting clonal expansion and differentiation. Even the roots of the hematopoietic system in cattle twins are thus strongly chimeric from the early stages of fetal development. However, the hematopoietic seeding of fetal liver apparently started already before the onset of functional vascular anastomosis.

  15. Method for observing phase objects without halos and directional shadows

    Science.gov (United States)

    Suzuki, Yoshimasa; Kajitani, Kazuo; Ohde, Hisashi

    2015-03-01

    A new microscopy method for observing phase objects without halos and directional shadows is proposed. The key optical element is an annular aperture at the front focal plane of a condenser with a larger diameter than those used in standard phase contrast microscopy. The light flux passing through the annular aperture is changed by the specimen's surface profile and then passes through an objective and contributes to image formation. This paper presents essential conditions for realizing the method. In this paper, images of colonies formed by induced pluripotent stem (iPS) cells using this method are compared with the conventional phase contrast method and the bright-field method when the NA of the illumination is small to identify differences among these techniques. The outlines of the iPS cells are clearly visible with this method, whereas they are not clearly visible due to halos when using the phase contrast method or due to weak contrast when using the bright-field method. Other images using this method are also presented to demonstrate a capacity of this method: a mouse ovum and superimposition of several different images of mouse iPS cells.

  16. First direct observation of time-reversal violation

    International Nuclear Information System (INIS)

    Angelopoulos, A.; Apostolakis, A.; Aslanides, E.; Bertin, V.; Ealet, A.; Henry-Couannier, F.; Le Gac, R.; Montanet, F.; Touchard, F.; Backenstoss, G.; Benelli, A.; Kokkas, P.; Leimgruber, F.; Pavlopoulos, P.; Polivka, G.; Rickenbach, R.; Schietinger, T.; Tauscher, L.; Vlachos, S.; Bargassa, P.

    2000-01-01

    Using its unique capability of strangeness tagging at K 0 production in pp-bar→K ± π ± K 0 (K-bar) 0 ) and at decay with the lepton charge in semileptonic decays CPLEAR measured the semileptonic decay-rate asymmetry (R(K-bar) 0 →e + π - ν)-R(K 0 →e - π + ν-bar)/R(K-bar) 0 →e + π - ν)+R(K 0 →e - π + ν-bar). The asymmetry, fitted over the eigentime interval 1-20 τ S , yielded a non-zero result of (6.6±1.3 stat ±1.1 syst )x10 -3 . A thorough phenomenological analysis identifies T violation in K 0 mixing and/or CPT violation in semileptonic decays as possible interpretations. A confrontation with world data on neutral kaon decays, however, excludes the latter with sufficient precision to establish the result as the first direct observation of time reversal non-invariance

  17. Working Group Report: WIMP Dark Matter Direct Detection

    International Nuclear Information System (INIS)

    Cushman, P.; Galbiati, C.; McKinsey, D. N.; Robertson, H.; Tait, T. M.P.

    2013-01-01

    As part of the Snowmass process, the Cosmic Frontier WIMP Direct Detection subgroup (CF1) has drawn on input from the Cosmic Frontier and the broader Particle Physics community to produce this document. The charge to CF1 was (a) to summarize the current status and projected sensitivity of WIMP direct detection experiments worldwide, (b) motivate WIMP dark matter searches over a broad parameter space by examining a spectrum of WIMP models, (c) establish a community consensus on the type of experimental program required to explore that parameter space, and (d) identify the common infrastructure required to practically meet those goals.

  18. Working Group Report: WIMP Dark Matter Direct Detection

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, P.; Galbiati, C.; McKinsey, D. N.; Robertson, H.; Tait, T. M.P.

    2013-10-30

    As part of the Snowmass process, the Cosmic Frontier WIMP Direct Detection subgroup (CF1) has drawn on input from the Cosmic Frontier and the broader Particle Physics community to produce this document. The charge to CF1 was (a) to summarize the current status and projected sensitivity of WIMP direct detection experiments worldwide, (b) motivate WIMP dark matter searches over a broad parameter space by examining a spectrum of WIMP models, (c) establish a community consensus on the type of experimental program required to explore that parameter space, and (d) identify the common infrastructure required to practically meet those goals.

  19. Who Uses Earth Observations? User Types in Group on Earth Observations

    Science.gov (United States)

    Fontaine, K. S.

    2011-12-01

    How can we communicate concepts in the physical sciences unless we know our audience? The Group on Earth Observations (GEO) User Interface Committee (UIC) has a responsibility within GEO to support and advocate for the user community in the development of Global Earth Observations System of Systems (GEOSS) and related work. As part of its efforts, the UIC has been working on developing a taxonomy that can be used to characterize the broad spectrum of users of GEOSS and its data, services, and applications. The user type taxonomy is designed to be broad and flexible but aims at describing the needs of the users GEOSS is going to serve. These user types represent a continuum of users of Earth observations from research through to decision support activities, and it includes organizations that use GEOSS as a tool to provide data and services for customers and consumers of the information. The classification scheme includes factors about skills and capacity for using Earth observations, sophistication level, spatial resolution, latency, and frequency of data. As part of the effort to develop a set of User Types, the GEO UIC foresees that those inside and outside GEO can use the typologies to understand how to engage users at a more effective level. This talk presents the GEOSS User Type taxonomy, explaining the development and highlights of key feedback. The talk will highlight possible ways to use the User Type taxonomy to communicate concepts and promote the use of Earth observations to a wide variety of users.

  20. Direct quantification of negatively charged functional groups on membrane surfaces

    KAUST Repository

    Tiraferri, Alberto; Elimelech, Menachem

    2012-01-01

    groups at the surface of dense polymeric membranes. Both techniques consist of associating the membrane surface moieties with chemical probes, followed by quantification of the bound probes. Uranyl acetate and toluidine blue O dye, which interact

  1. Modelling 1-minute directional observations of the global irradiance.

    Science.gov (United States)

    Thejll, Peter; Pagh Nielsen, Kristian; Andersen, Elsa; Furbo, Simon

    2016-04-01

    Direct and diffuse irradiances from the sky has been collected at 1-minute intervals for about a year from the experimental station at the Technical University of Denmark for the IEA project "Solar Resource Assessment and Forecasting". These data were gathered by pyrheliometers tracking the Sun, as well as with apertured pyranometers gathering 1/8th and 1/16th of the light from the sky in 45 degree azimuthal ranges pointed around the compass. The data are gathered in order to develop detailed models of the potentially available solar energy and its variations at high temporal resolution in order to gain a more detailed understanding of the solar resource. This is important for a better understanding of the sub-grid scale cloud variation that cannot be resolved with climate and weather models. It is also important for optimizing the operation of active solar energy systems such as photovoltaic plants and thermal solar collector arrays, and for passive solar energy and lighting to buildings. We present regression-based modelling of the observed data, and focus, here, on the statistical properties of the model fits. Using models based on the one hand on what is found in the literature and on physical expectations, and on the other hand on purely statistical models, we find solutions that can explain up to 90% of the variance in global radiation. The models leaning on physical insights include terms for the direct solar radiation, a term for the circum-solar radiation, a diffuse term and a term for the horizon brightening/darkening. The purely statistical model is found using data- and formula-validation approaches picking model expressions from a general catalogue of possible formulae. The method allows nesting of expressions, and the results found are dependent on and heavily constrained by the cross-validation carried out on statistically independent testing and training data-sets. Slightly better fits -- in terms of variance explained -- is found using the purely

  2. Directional selection causes decanalization in a group I ribozyme.

    Science.gov (United States)

    Hayden, Eric J; Weikert, Christian; Wagner, Andreas

    2012-01-01

    A canalized genotype is robust to environmental or genetic perturbations. Canalization is expected to result from stabilizing selection on a well-adapted phenotype. Decanalization, the loss of robustness, might follow periods of directional selection toward a new optimum. The evolutionary forces causing decanalization are still unknown, in part because it is difficult to determine the fitness effects of mutations in populations of organisms with complex genotypes and phenotypes. Here, we report direct experimental measurements of robustness in a system with a simple genotype and phenotype, the catalytic activity of an RNA enzyme. We find that the robustness of a population of RNA enzymes decreases during a period of directional selection in the laboratory. The decrease in robustness is primarily caused by the selective sweep of a genotype that is decanalized relative to the wild-type, both in terms of mutational robustness and environmental robustness (thermodynamic stability). Our results experimentally demonstrate that directional selection can cause decanalization on short time scales, and demonstrate co-evolution of mutational and environmental robustness.

  3. Direct observation of two proton radioactivity using digital photography

    International Nuclear Information System (INIS)

    Rykaczewski, Krzysztof Piotr; Pfutzner, M.; Dominik, Wojciech; Janas, Z.; Miernik, K.; Bingham, C.R.; Czyrkowski, HenryK.; Cwiok, Mikolaj; Darby, Iain; Dabrowski, Ryszard; Ginter, T. N.; Grzywacz, Robert Kazimierz; Karny, M.; Korgul, A.; Kusmierz, Waldemar; Liddick, Sean; Rajabali, Mustafa; Stolz, A.

    2007-01-01

    Recently the observation of a new type of spontaneous radioactive decay has been claimed in which two protons are simultaneously ejected by an atomic nucleus from the ground state1,2,3. Experimental data obtained for the extremely neutron-deficient nuclei 45Fe and 54Zn, were interpreted as the first evidence of such a decay mode which has been sought since 1960.4 However, the technique applied in those studies allowed only measurements of the decay time and the total energy released. Particles emitted in the decay were not identified and the conclusions had to be supported by theoretical arguments. Here we show for the first time, directly and unambiguously, that 45Fe indeed disintegrates by two-proton decay. Furthermore, we demonstrate that the decay branch of this isotope leads to various particle emission channels including two-proton and three-proton emission. To achieve this result we have developed a new type of detector V the Optical Time Projection Chamber (OTPC) in which digital photography is applied to nuclear physics for the first time. The detector records images of tracks from charged particles, allowing for their unambiguous identification and the reconstruction of decay events in three dimensions. This new and simple technique provides a powerful method to identify exotic decay channels involving emission of charged particles. It is expected that further studies with the OTPC device will yield important information on nuclei located at and beyond the proton drip-line, thus providing new material for testing and improving models of very unstable atomic nuclei

  4. Attainment of students’ conception in magnetic fields by using of direct observation and symbolic language ability

    Science.gov (United States)

    Desy Fatmaryanti, Siska; Suparmi; Sarwanto; Ashadi

    2017-11-01

    This study focuses on description attainment of students’ conception in the magnetic field. The conception was based by using of direct observation and symbolic language ability. The method used is descriptive quantitative research. The subject of study was about 86 students from 3 senior high school at Purworejo. The learning process was done by guided inquiry model. During the learning, students were required to actively investigate the concept of a magnetic field around a straight wire electrical current Data retrieval was performed using an instrument in the form of a multiple choice test reasoned and observation during the learning process. There was four indicator of direct observation ability and four indicators of symbolic language ability to grouping category of students conception. The results of average score showed that students conception about the magnitude more better than the direction of magnetic fields in view of symbolic language. From the observation, we found that students could draw the magnetic fields line not from a text book but their direct observation results. They used various way to get a good accuracy of observation results. Explicit recommendations are presented in the discussion section at the end of this paper.

  5. Direct quantification of negatively charged functional groups on membrane surfaces

    KAUST Repository

    Tiraferri, Alberto

    2012-02-01

    Surface charge plays an important role in membrane-based separations of particulates, macromolecules, and dissolved ionic species. In this study, we present two experimental methods to determine the concentration of negatively charged functional groups at the surface of dense polymeric membranes. Both techniques consist of associating the membrane surface moieties with chemical probes, followed by quantification of the bound probes. Uranyl acetate and toluidine blue O dye, which interact with the membrane functional groups via complexation and electrostatic interaction, respectively, were used as probes. The amount of associated probes was quantified using liquid scintillation counting for uranium atoms and visible light spectroscopy for the toluidine blue dye. The techniques were validated using self-assembled monolayers of alkanethiols with known amounts of charged moieties. The surface density of negatively charged functional groups of hand-cast thin-film composite polyamide membranes, as well as commercial cellulose triacetate and polyamide membranes, was quantified under various conditions. Using both techniques, we measured a negatively charged functional group density of 20-30nm -2 for the hand-cast thin-film composite membranes. The ionization behavior of the membrane functional groups, determined from measurements with toluidine blue at varying pH, was consistent with published data for thin-film composite polyamide membranes. Similarly, the measured charge densities on commercial membranes were in general agreement with previous investigations. The relative simplicity of the two methods makes them a useful tool for quantifying the surface charge concentration of a variety of surfaces, including separation membranes. © 2011 Elsevier B.V.

  6. Signed directed social network analysis applied to group conflict

    DEFF Research Database (Denmark)

    Zheng, Quan; Skillicorn, David; Walther, Olivier

    2015-01-01

    Real-world social networks contain relationships of multiple different types, but this richness is often ignored in graph-theoretic modelling. We show how two recently developed spectral embedding techniques, for directed graphs (relationships are asymmetric) and for signed graphs (relationships...... are both positive and negative), can be combined. This combination is particularly appropriate for intelligence, terrorism, and law enforcement applications. We illustrate by applying the novel embedding technique to datasets describing conflict in North-West Africa, and show how unusual interactions can...

  7. Rhodium-catalyzed regioselective olefination directed by a carboxylic group.

    Science.gov (United States)

    Mochida, Satoshi; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro

    2011-05-06

    The ortho-olefination of benzoic acids can be achieved effectively through rhodium-catalyzed oxidative coupling with alkenes. The carboxylic group is readily removable to allow ortho-olefination/decarboxylation in one pot. α,β-Unsaturated carboxylic acids such as methacrylic acid also undergo the olefination at the β-position. Under the rhodium catalysis, the cine-olefination of heteroarene carboxylic acids such as thiophene-2-carboxylic acid proceeds smoothly accompanied by decarboxylation to selectively produce the corresponding vinylheteroarene derivatives. © 2011 American Chemical Society

  8. Directional Wave Spectra Observed During Intense Tropical Cyclones

    Science.gov (United States)

    Collins, C. O.; Potter, H.; Lund, B.; Tamura, H.; Graber, H. C.

    2018-02-01

    Two deep-sea moorings were deployed 780 km off the coast of southern Taiwan for 4-5 months during the 2010 typhoon season. Directional wave spectra, wind speed and direction, and momentum fluxes were recorded on two Extreme Air-Sea Interaction buoys during the close passage of Severe Tropical Storm Dianmu and three tropical cyclones (TCs): Typhoon Fanapi, Super Typhoon Megi, and Typhoon Chaba. Conditions sampled include significant wave heights up to 11 m and wind speeds up to 26 m s-1. Details varied for large-scale spectral structure in frequency and direction but were mostly bimodal. The modes were generally composed of a swell system emanating from the most intense storm region and local wind-seas. The peak systems were consistently young, meaning actively forced by winds, when the storms were close. During the peaks of the most intense passages—Chaba at the northern mooring and Megi at the southern—the bimodal seas coalesced. During Chaba, the swell and wind-sea coupling directed the high frequency waves and the wind stress away from the wind direction. A spectral wave model was able reproduce many of the macrofeatures of the directional spectra.

  9. Three-item Direct Observation Screen (TIDOS) for autism spectrum disorder

    OpenAIRE

    Oner, Pinar; Oner, Ozgur; Munir, Kerim

    2013-01-01

    We compared ratings on the Three-Item Direct Observation Screen test for autism spectrum disorders completed by pediatric residents with the Social Communication Questionnaire parent reports as an augmentative tool for improving autism spectrum disorder screening performance. We examined three groups of children (18–60 months) comparable in age (18–24 month, 24–36 month, 36–60 preschool subgroups) and gender distribution: n = 86 with Diagnostic and Statistical Manual of Mental Disorders (4th ...

  10. Physics Implications of Flat Directions in Free Fermionic Superstring Models; 2, Renormalization Group Analysis

    CERN Document Server

    Cleaver, G.; Espinosa, J.R.; Everett, L.L.; Langacker, P.; Wang, J.

    1999-01-01

    We continue the investigation of the physics implications of a class of flat directions for a prototype quasi-realistic free fermionic string model (CHL5), building upon the results of the previous paper in which the complete mass spectrum and effective trilinear couplings of the observable sector were calculated to all orders in the superpotential. We introduce soft supersymmetry breaking mass parameters into the model, and investigate the gauge symmetry breaking patterns and the renormalization group analysis for two representative flat directions, which leave an additional $U(1)'$ as well as the SM gauge group unbroken at the string scale. We study symmetry breaking patterns that lead to a phenomenologically acceptable $Z-Z'$ hierarchy, $M_{Z^{'}} \\sim {\\cal O}(1~{\\rm TeV})$ and $ 10^{12}~{\\rm GeV}$ for electroweak and intermediate scale $U(1)^{'}$ symmetry breaking, respectively, and the associated mass spectra after electroweak symmetry breaking. The fermion mass spectrum exhibits unrealistic features, i...

  11. Using direct clinical observation to assess the quality of cesarean delivery in Afghanistan: an exploratory study

    Science.gov (United States)

    2014-01-01

    Background As part of a National Emergency Obstetric and Newborn Care (EmONC) Needs Assessment, a special study was undertaken in July 2010 to examine the quality of cesarean deliveries in Afghanistan and examine the utility of direct clinical observation as an assessment method in low-resource settings. Methods This cross-sectional assessment of the quality of cesareans at 14 facilities in Afghanistan included a survey of surgeons regarding their routine cesarean practices, direct observation of 29 cesarean deliveries and comparison of observations with facility records for 34 additional cesareans conducted during the 3 days prior to the observation period at each facility. For both observed cases and record reviews, we assessed time intervals between specified points of care-arrival to the ward, first evaluation, detection of a complication, decision for cesarean, incision, and birth. Results All time intervals with the exception of “decision to skin incision” were longer in the record reviews than in observed cases. Prior cesarean was the most common primary indication for all cases. All mothers in both groups observed survived through one hour postpartum. Among newborns there were two stillbirths (7%) in observed births and seven (21%) record reviews. Although our sample is too small to show statistical significance, the difference is noteworthy. In six of the reviewed cesareans resulting in stillbirth, a fetal heart rate was recorded in the operating theater, although four were recorded as macerated. For the two fresh stillbirths, the cesarean surgeries were recorded as scheduled and not urgent. Conclusions Direct observation of cesarean deliveries enabled us to assess a number of preoperative, postoperative, and intraoperative procedures that are often not described in medical records in low resource settings. Comparison of observations with findings from provider interviews and facility records allowed us to infer whether observed practices were typical

  12. A New Method to Directly Observe Tuberculosis Treatment: Skype Observed Therapy, a Patient-Centered Approach.

    Science.gov (United States)

    Buchman, Tavora; Cabello, Celina

    Tuberculosis (TB) treatment completion is in part determined by patient's adherence to long-term drug regimens. To best ensure compliance, directly observed therapy (DOT) is considered the standard of practice. Nassau County Department of Health TB Control is responsible for providing DOT to patients with TB. Tuberculosis Control sought to use and evaluate Skype Observed Therapy (SOT) as an alternative to DOT for eligible patients. The evaluation included analysis of patient's acceptance and adherence to drug regimen using SOT. Tuberculosis Control assessed staff efficiency and cost savings for this program. Percentages of SOT of patients and successful SOT visits, mileage, and travel time savings. Twenty percent of the caseload used SOT and 100% of patients who were eligible opted in. Average SOT success was 79%. Total mileage savings and time saved were $9,929.07 and 614 hours. Because SOT saves cost and time and is a suitable alternative to DOT for patients, it should be considered as part of new policies and practices in TB control programs.

  13. Sensitization to group direction in the postgraduate training on Group-Analysis

    Directory of Open Access Journals (Sweden)

    Simone Bruschetta

    2014-09-01

    Full Text Available The psychodynamic training group here introduced is a part of the General Training on Group Analysis of the Centre of Palermo of COIRAG Postgraduate School on Analytic Psychotherapy. The training project’s aim, built for the class of the third year, develops a sensitization device which provide a unique set of aquarium. The aim of that methodological artifice is not to engage students on specific group management techniques, but to allow the whole class group to bring into play the complexity of relations, of which is necessary to have awareness in order to lead a group within an institutional context: The main clinical referents that we chose to monitor in this experience are the relationship between conductors and participants and the relationship between group, task and setting. The brief description of this methodology is also including the reporting of two "cases" treated in the course of training. Keywords: Group leadership, Founding dimension, Cultural themes 

  14. Direct observation of rectified motion of vortices by Lorentz microscopy

    Indian Academy of Sciences (India)

    one-directional selective motion of field-gradient-driven vortices along fabricated channels. This results from ... was irradiated around etched holes to fabricate the asymmetric potential [19]. Fig- ures 1a .... The dotted line is a guide to the eye.

  15. Direct Observation of Zitterbewegung in a Bose Einstein Condensate

    Science.gov (United States)

    2013-07-03

    analogous to the Higgs mechanism where a Higgs condensate (a coherent matter wave) generates mass in the standard model [28].) The zitterbewegung of...directly realize Dirac– boson systems in the laboratory [12, 29], permitting access to new classes of experimental systems. Though BECs near these Dirac...http://www.njp.org/) 10 in an optical lattice, can stably populate these states [34, 35], for example leading to bosonic composite-fermion states [36, 37

  16. The nature of the redshift and directly observed quasar statistics.

    Science.gov (United States)

    Segal, I E; Nicoll, J F; Wu, P; Zhou, Z

    1991-07-01

    The nature of the cosmic redshift is one of the most fundamental questions in modern science. Hubble's discovery of the apparent Expansion of the Universe is derived from observations on a small number of galaxies at very low redshifts. Today, quasar redshifts have a range more than 1000 times greater than those in Hubble's sample, and represent more than 100 times as many objects. A recent comprehensive compilation of published measurements provides the basis for a study indicating that quasar observations are not in good agreement with the original predictions of the Expanding Universe theory, but are well fit by the predictions of an alternative theory having fewer adjustable parameters.

  17. Clear Direction. The Montessori Observer. Volume 32, Number 2

    Science.gov (United States)

    International Montessori Society (NJ3), 2011

    2011-01-01

    "The Montessori Observer" is mailed four times each year, in March, May, September and November, to Society members throughout the world. The purpose is to provide news and information about the Society's work in Montessori education, and to extend awareness of Montessori principles throughout the world. This issue contains a feature…

  18. Directly observed road safety compliance by Motor Cycle Riders ...

    African Journals Online (AJOL)

    Objective: To assess the extent of compliance with road safety regulations by motorcycle riders following a five year road safety campaign in Naivasha town, Kenya. Design: A cross sectional study. Setting: Naivasha town, Nakuru county, Kenya. Results: A total of 9,280 MCs ferrying 13,733 people were observed. Less than ...

  19. Direct observation of localized dipolar excitations on rough nanostructured surfaces

    DEFF Research Database (Denmark)

    Bozhevolnyi, Sergey I.; Markel, V.A.; Coello, V.

    1998-01-01

    Using a photon scanning tunneling microscope (operating alternatively at the wavelengths of 594 and 633 nm) with shear-force feedback we image the topography of silver colloid fractals simultaneously with a near-field intensity distribution. We observe that near-field optical images exhibit...

  20. Observations of Adolescent Peer Group Interactions as a Function of Within- and Between-Group Centrality Status

    Science.gov (United States)

    Ellis, Wendy E.; Dumas, Tara M.; Mahdy, Jasmine C.; Wolfe, David A.

    2012-01-01

    Observations of adolescent (n = 258; M age = 15.45) peer group triads (n = 86) were analyzed to identify conversation and interaction styles as a function of within-group and between-group centrality status. Group members' discussions about hypothetical dilemmas were coded for agreements, disagreements, commands, and opinions. Interactions during…

  1. Three-item Direct Observation Screen (TIDOS) for autism spectrum disorder.

    Science.gov (United States)

    Oner, Pinar; Oner, Ozgur; Munir, Kerim

    2014-08-01

    We compared ratings on the Three-Item Direct Observation Screen test for autism spectrum disorders completed by pediatric residents with the Social Communication Questionnaire parent reports as an augmentative tool for improving autism spectrum disorder screening performance. We examined three groups of children (18-60 months) comparable in age (18-24 month, 24-36 month, 36-60 preschool subgroups) and gender distribution: n = 86 with Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) autism spectrum disorders; n = 76 with developmental delay without autism spectrum disorders; and n = 97 with typical development. The Three-Item Direct Observation Screen test included the following (a) Joint Attention, (b) Eye Contact, and (c) Responsiveness to Name. The parent Social Communication Questionnaire ratings had a sensitivity of .73 and specificity of .70 for diagnosis of autism spectrum disorders. The Three-Item Direct Observation Screen test item Joint Attention had a sensitivity of .82 and specificity of .90, Eye Contact had a sensitivity of .89 and specificity of .91, and Responsiveness to Name had a sensitivity of .67 and specificity of .87. In the Three-Item Direct Observation Screen test, having at least one of the three items positive had a sensitivity of .95 and specificity of .85. Age, diagnosis of autism spectrum disorder, and developmental level were important factors affecting sensitivity and specificity. The results indicate that augmentation of autism spectrum disorder screening by observational items completed by trained pediatric-oriented professionals can be a highly effective tool in improving screening performance. If supported by future population studies, the results suggest that primary care practitioners will be able to be trained to use this direct procedure to augment screening for autism spectrum disorders in the community. © The Author(s) 2013.

  2. Direct observation of nanoparticle-cancer cell nucleus interactions.

    Science.gov (United States)

    Dam, Duncan Hieu M; Lee, Jung Heon; Sisco, Patrick N; Co, Dick T; Zhang, Ming; Wasielewski, Michael R; Odom, Teri W

    2012-04-24

    We report the direct visualization of interactions between drug-loaded nanoparticles and the cancer cell nucleus. Nanoconstructs composed of nucleolin-specific aptamers and gold nanostars were actively transported to the nucleus and induced major changes to the nuclear phenotype via nuclear envelope invaginations near the site of the construct. The number of local deformations could be increased by ultrafast, light-triggered release of the aptamers from the surface of the gold nanostars. Cancer cells with more nuclear envelope folding showed increased caspase 3 and 7 activity (apoptosis) as well as decreased cell viability. This newly revealed correlation between drug-induced changes in nuclear phenotype and increased therapeutic efficacy could provide new insight for nuclear-targeted cancer therapy.

  3. Direct observation of coherent energy transfer in nonlinear micromechanical oscillators.

    Science.gov (United States)

    Chen, Changyao; Zanette, Damián H; Czaplewski, David A; Shaw, Steven; López, Daniel

    2017-05-26

    Energy dissipation is an unavoidable phenomenon of physical systems that are directly coupled to an external environmental bath. In an oscillatory system, it leads to the decay of the oscillation amplitude. In situations where stable oscillations are required, the energy dissipated by the vibrations is usually compensated by replenishment from external energy sources. Consequently, if the external energy supply is removed, the amplitude of oscillations start to decay immediately, since there is no means to restitute the energy dissipated. Here, we demonstrate a novel dissipation engineering strategy that can support stable oscillations without supplying external energy to compensate losses. The fundamental intrinsic mechanism of resonant mode coupling is used to redistribute and store mechanical energy among vibrational modes and coherently transfer it back to the principal mode when the external excitation is off. To experimentally demonstrate this phenomenon, we exploit the nonlinear dynamic response of microelectromechanical oscillators to couple two different vibrational modes through an internal resonance.

  4. Direct observation of vibrational energy flow in cytochrome c.

    Science.gov (United States)

    Fujii, Naoki; Mizuno, Misao; Mizutani, Yasuhisa

    2011-11-10

    Vibrational energy flow in ferric cytochrome c has been examined by picosecond time-resolved anti-Stokes ultraviolet resonance Raman (UVRR) measurements. By taking advantage of the extremely short nonradiative excited state lifetime of heme in the protein (energy of 20000-25000 cm(-1) was optically deposited selectively at the heme site. Subsequent energy relaxation in the protein moiety was investigated by monitoring the anti-Stokes UVRR intensities of the Trp59 residue, which is a single tryptophan residue involved in the protein that is located close to the heme group. It was found from temporal changes of the anti-Stokes UVRR intensities that the energy flow from the heme to Trp59 and the energy release from Trp59 took place with the time constants of 1-3 and ~8 ps, respectively. These data are consistent with the time constants for the vibrational relaxation of the heme and heating of water reported for hemeproteins. The kinetics of the energy flow were not affected by the amount of excess energy deposited at the heme group. These results demonstrate that the present technique is a powerful tool for studying the vibrational energy flow in proteins.

  5. Radiation damage in dielectric and semiconductor single crystals (direct observation)

    CERN Document Server

    Adawi, M A; Varichenko, V S; Zaitsev, A M

    1998-01-01

    The surfaces of boron-doped synthetic and natural diamonds have been investigated by using the scanning tunnelling microscope (STM) and the scanning electronic microscope (SEM) before and after irradiating the samples with sup 4 sup 0 Ar (25 MeV), sup 8 sup 4 Kr (210 MeV) and sup 1 sup 2 sup 5 Xe (124 MeV) ions. The structures observed after irradiation showed craters with diameters ranging from 3 nm up to 20 nm, which could be interpreted as single ion tracks and multiple hits of ions at the nearest positions of the surface. In the case of argon ion irradiation, the surface was found to be completely amorphous, but after xenon irradiation one could see parts of surface without amorphism. This can be explained by the influence of high inelastic energy losses. The energy and temperature criteria of crater formation as a result of heavy ion irradiation are introduced.

  6. New Directions in the NOAO Observing Proposal System

    Science.gov (United States)

    Gasson, David; Bell, Dave

    For the past eight years NOAO has been refining its on-line observing proposal system. Virtually all related processes are now handled electronically. Members of the astronomical community can submit proposals through email, web form, or via the Gemini Phase I Tool. NOAO staff can use the system to do administrative tasks, scheduling, and compilation of various statistics. In addition, all information relevant to the TAC process is made available on-line, including the proposals themselves (in HTML, PDF and PostScript) and technical comments. Grades and TAC comments are entered and edited through web forms, and can be sorted and filtered according to specified criteria. Current developments include a move away from proprietary solutions, toward open standards such as SQL (in the form of the MySQL relational database system), Perl, PHP and XML.

  7. Time of default in tuberculosis patients on directly observed treatment.

    Science.gov (United States)

    Pardeshi, Geeta S

    2010-09-01

    Default remains an important challenge for the Revised National Tuberculosis Control Programme, which has achieved improved cure rates. This study describes the pattern of time of default in patients on DOTS. Tuberculosis Unit in District Tuberculosis Centre, Yavatmal, India; Retrospective cohort study. This analysis was done among the cohort of patients of registered at the Tuberculosis Unit during the year 2004. The time of default was assessed from the tuberculosis register. The sputum smear conversion and treatment outcome were also assessed. Kaplan-Meier plots and log rank tests. Overall, the default rate amongst the 716 patients registered at the Tuberculosis Unit was 10.33%. There was a significant difference in the default rate over time between the three DOTS categories (log rank statistic= 15.49, P=0.0004). Amongst the 331 smear-positive patients, the cumulative default rates at the end of intensive phase were 4% and 16%; while by end of treatment period, the default rates were 6% and 31% in category I and category II, respectively. A majority of the smear-positive patients in category II belonged to the group 'treatment after default' (56/95), and 30% of them defaulted during re-treatment. The sputum smear conversion rate at the end of intensive phase was 84%. Amongst 36 patients without smear conversion at the end of intensive phase, 55% had treatment failure. Patients defaulting in intensive phase of treatment and without smear conversion at the end of intensive phase should be retrieved on a priority basis. Default constitutes not only a major reason for patients needing re-treatment but also a risk for repeated default.

  8. Jupiter Trojan's Shallow Subsurface: Direct Observation By Radar Sounding

    Science.gov (United States)

    Herique, A.; Plettemeier, D.; Beck, P.; Michel, P.; Kumamoto, A.; Kofman, W. W.

    2017-12-01

    Most of the Jupiter's Trojan are classified as spectral type P or D from visible and near-IR observations. Still, major question remain regarding theire origin and geological evolution: What ices are present in their interior, and in what amount? What is the abundance and the nature of the organic fraction? Did they experience some level of differentiation powered by 26Al? Answering theses question is the goal of the Solar-Power Sail JAXA mission [1, 2]. This mission plans to study the surface by remote sensing in the optical in IR domain. This probe will carry a large-sized lander with a drill to sample the constitutive material at meter depth in order to complement physical and chemical properties measured by on-board instruments. The sample return is an option under study.Radar sounding of the shallow subsurface would be envisaged in complement to this payload. Sounding radar could provide the structure of the first tens of meters of the Trojan surface. It will allow identifying layering, ice lens, and embedded block. It also will enable to reconnect the surface with the deep interior in order to identify exogenous / pristine material. For the surface package, the drilling and the sample return, radar sounding is a unique opportunity to support the selection of the landing site and to provide the greater geological context of the samples that will be returned to Earth.In this paper, we will detail the objective of this instrument and then we will outline the proposed instrument, which is inheriting from the radar developed for the AIDA/AIM mission.[1] Mori, O. et al., Science experiments on a Jupiter Trojan Asteroid in the solar powerd sail mission. LPSC 2016 - 1822.[2] Okada, T. et al., Science and Exploration of a Jupiter Trojan Asteroid in the solar-power sail mission. LPSC 2017 - 1828.

  9. Direct observations of the atmospheric processing of Asian mineral dust

    Directory of Open Access Journals (Sweden)

    R. C. Sullivan

    2007-01-01

    Full Text Available The accumulation of secondary acids and ammonium on individual mineral dust particles during ACE-Asia has been measured with an online single-particle mass spectrometer, the ATOFMS. Changes in the amounts of sulphate, nitrate, and chloride mixed with dust particles correlate with air masses from different source regions. The uptake of secondary acids depended on the individual dust particle mineralogy; high amounts of nitrate accumulated on calcium-rich dust while high amounts of sulphate accumulated on aluminosilicate-rich dust. Oxidation of S(IV to S(VI by iron in the aluminosilicate dust is a possible explanation for this enrichment of sulphate, which has important consequences for the fertilization of remote oceans by soluble iron. This study shows the segregation of sulphate from nitrate and chloride in individual aged dust particles for the first time. A transport and aging timeline provides an explanation for the observed segregation. Our data suggests that sulphate became mixed with the dust first. This implies that the transport pathway is more important than the reaction kinetics in determining which species accumulate on mineral dust. Early in the study, dust particles in volcanically influenced air masses were mixed predominately with sulphate. Dust mixed with chloride then dominated over sulphate and nitrate when a major dust front reached the R. V. Ronald Brown. We hypothesize that the rapid increase in chloride on dust was due to mixing with HCl(g released from acidified sea salt particles induced by heterogeneous reaction with volcanic SO2(g, prior to the arrival of the dust front. The amount of ammonium mixed with dust correlated strongly with the total amount of secondary acid reaction products in the dust. Submicron dust and ammonium sulphate were internally mixed, contrary to frequent reports that they exist as external mixtures. The size distribution of the mixing state of dust with these secondary species validates previous

  10. Observations of a bi-directional lightning leader producing an M-component

    Science.gov (United States)

    Kotovsky, D. A.; Uman, M. A.; Wilkes, R.; Carvalho, F. L.; Jordan, D. M.

    2017-12-01

    Lightning discharges to ground often exhibit millisecond-scale surges in the continuing currents following return strokes, called M-components. Relatively little is known regarding the source of M-component charge and the mechanisms by which that charge is transferred to ground. In this work, we seek to directly address these questions by presenting correlated high-speed video and Lightning Mapping Array (LMA) observations of a bi-directional leader that resulted in an M-component occurring in a rocket-and-wire triggered lightning flash. The observed leader initiated in the decayed remnants of a positive leader channel that had traversed virgin air approximately 90 msec prior. Three-dimensional locations and speeds of the photographed bi-directional leader and M-component processes are calculated by mapping video images to the observed LMA channel geometry. Both ends of the bi-directional leader exhibited speeds on the order of 2 x106 m sec-1 over 570 meters of the visible channel. Propagation of the luminosity wave from the in-cloud leader to ground ( 8.8 km channel length) exhibited appreciable dispersion, with rise-times (10-90%) increasing from 330 to 410 μsec and pulse-widths (half-maximum) increasing from 380 to 810 μsec - the M-component current pulse measured at ground-level exhibited a rise-time of 290 μsec and a pulse-width of 770 μsec. Group velocities of the luminosity wave have been calculated as a function of frequency, increasing from 2 x107 to 6 x107 m sec-1 over the dominant signal bandwidth (DC to 2 kHz). Additionally, multiple waves of luminosity are observed within the in-cloud channel, indicating nuanced wave phenomena possibly associated with reflection from the end of the leader channel and attachment with the main lightning channel carrying continuing current to ground.

  11. Direct observation of syringeal muscle function in songbirds and a parrot

    DEFF Research Database (Denmark)

    Larsen, Ole Næsbye; Goller, Franz

    2002-01-01

    on the syrinx. Contraction of m. tracheobronchialis ventralis enlarges the syringeal lumen and thus increases airflow by abducting the LL but does not affect the ML. The largest syringeal muscle, m. syringealis ventralis, plays a minor role, if any, in direct aperture control and thus in gating airflow...... the LTMs further into the tracheal lumen but does not close the syringeal aperture fully. The intrinsic deep muscle, m. syringealis profundus, abducts the LTMs through cranio-laterad movement of a paired, protruding half-ring. The weakly developed extrinsic m. sternotrachealis seems to increase tension......The role of syringeal muscles in controlling the aperture of the avian vocal organ, the syrinx, was evaluated directly for the first time by observing and filming through an endoscope while electrically stimulating different muscle groups of anaesthetised birds. In songbirds (brown thrashers...

  12. The uses of an observation team with a parent support group.

    Science.gov (United States)

    O'Brien, P J

    1994-04-01

    This brief report examines the uses of an Observation Team with a Parent Support Group. In particular, attention is placed on the idea of the Observation Team acting as a Reflecting Team in the final session of the group's life. Using the Observation Team in this manner has evolved from an amalgamation of ideas from family therapy and group therapy theory.

  13. Physics implications of flat directions in free fermionic superstring models. II. Renormalization group analysis

    International Nuclear Information System (INIS)

    Cleaver, G.; Cvetic, M.; Everett, L.; Langacker, P.; Wang, J.; Espinosa, J.R.; Everett, L.

    1999-01-01

    We continue the investigation of the physics implications of a class of flat directions for a prototype quasi-realistic free fermionic string model (CHL5), building upon the results of a previous paper in which the complete mass spectrum and effective trilinear couplings of the observable sector were calculated to all orders in the superpotential. We introduce soft supersymmetry breaking mass parameters into the model, and investigate the gauge symmetry breaking patterns and the renormalization group analysis for two representative flat directions, which leave an additional U(1) ' as well as the SM gauge group unbroken at the string scale. We study symmetry breaking patterns that lead to a phenomenologically acceptable Z-Z ' hierarchy, M Z ' ∼O(1 TeV) and 10 12 GeV for electroweak and intermediate scale U(1) ' symmetry breaking, respectively, and the associated mass spectra after electroweak symmetry breaking. The fermion mass spectrum exhibits unrealistic features, including massless exotic fermions, but has an interesting d-quark hierarchy and associated CKM matrix in one case. There are (some) non-canonical effective μ terms, which lead to a non-minimal Higgs sector with more than two Higgs doublets involved in the symmetry breaking, and a rich structure of Higgs particles, charginos, and neutralinos, some of which, however, are massless or ultralight. In the electroweak scale cases the scale of supersymmetry breaking is set by the Z ' mass, with the sparticle masses in the several TeV range. copyright 1999 The American Physical Society

  14. Assessing distractors and teamwork during surgery: developing an event-based method for direct observation.

    Science.gov (United States)

    Seelandt, Julia C; Tschan, Franziska; Keller, Sandra; Beldi, Guido; Jenni, Nadja; Kurmann, Anita; Candinas, Daniel; Semmer, Norbert K

    2014-11-01

    To develop a behavioural observation method to simultaneously assess distractors and communication/teamwork during surgical procedures through direct, on-site observations; to establish the reliability of the method for long (>3 h) procedures. Observational categories for an event-based coding system were developed based on expert interviews, observations and a literature review. Using Cohen's κ and the intraclass correlation coefficient, interobserver agreement was assessed for 29 procedures. Agreement was calculated for the entire surgery, and for the 1st hour. In addition, interobserver agreement was assessed between two tired observers and between a tired and a non-tired observer after 3 h of surgery. The observational system has five codes for distractors (door openings, noise distractors, technical distractors, side conversations and interruptions), eight codes for communication/teamwork (case-relevant communication, teaching, leadership, problem solving, case-irrelevant communication, laughter, tension and communication with external visitors) and five contextual codes (incision, last stitch, personnel changes in the sterile team, location changes around the table and incidents). Based on 5-min intervals, Cohen's κ was good to excellent for distractors (0.74-0.98) and for communication/teamwork (0.70-1). Based on frequency counts, intraclass correlation coefficient was excellent for distractors (0.86-0.99) and good to excellent for communication/teamwork (0.45-0.99). After 3 h of surgery, Cohen's κ was 0.78-0.93 for distractors, and 0.79-1 for communication/teamwork. The observational method developed allows a single observer to simultaneously assess distractors and communication/teamwork. Even for long procedures, high interobserver agreement can be achieved. Data collected with this method allow for investigating separate or combined effects of distractions and communication/teamwork on surgical performance and patient outcomes. Published by the

  15. Permeability Changes Observed in the Arbuckle Group Coincident with Nearby Earthquake Occurrence

    Science.gov (United States)

    Kroll, K.; Cochran, E. S.; Richards-Dinger, K. B.; Murray, K.

    2017-12-01

    We investigate the temporal evolution of hydrologic properties of the 2 km deep Arbuckle Group, the principal target in Oklahoma for saltwater disposal resulting from oil and gas production. Specifically, we look for changes to the hydrologic system associated with local earthquakes at two monitoring wells (Payne07 and 08) near Cushing, Oklahoma. The wells were instrumented with pressure transducers starting in Aug. 2016, after injection was discontinued due to regulatory directives. The observation period includes the 3 Sep 2016 Mw5.8 Pawnee and 7 Nov. 2016 Mw5.0 Cushing earthquakes located 50 km and 5 km from the wells, respectively. Previous studies have suggested the Mw5.8 Pawnee earthquake affected both the shallow and deep hydrological systems, with an increase in stream discharge observed near the mainshock (Manga et al., 2016) and a change in poroelastic properties of the Arbuckle inferred from the observed co-seismic water level offsets observed at Payne 07 and 08 (Kroll et al., 2017). Here, we use the water level response to solid Earth tides to estimate permeability and specific storage through time during the observation period. We measure the phase lag between the solid Earth tide and the water level changes and find that phase lag between the Earth tide and aquifer response decreases at the time of the Mw5.0 Cushing earthquake in both wells. Our results suggest permeability increased in the Arbuckle Group after the earthquake by a factor of 5. It is possible that in extreme cases there may be complex interaction between saltwater disposal, hydrologic systems, and earthquake rates that should be considered to better understand seismic hazard.

  16. Effect of phase-encoding direction on group analysis of resting-state functional magnetic resonance imaging.

    Science.gov (United States)

    Mori, Yasuo; Miyata, Jun; Isobe, Masanori; Son, Shuraku; Yoshihara, Yujiro; Aso, Toshihiko; Kouchiyama, Takanori; Murai, Toshiya; Takahashi, Hidehiko

    2018-05-17

    Echo-planar imaging is a common technique used in functional magnetic resonance imaging (fMRI), however it suffers from image distortion and signal loss because of large susceptibility effects that are related to the phase-encoding direction of the scan. Despite this relationship, the majority of neuroimaging studies have not considered the influence of phase-encoding direction. Here, we aimed to clarify how phase-encoding direction can affect the outcome of an fMRI connectivity study of schizophrenia. Resting-state fMRI using anterior to posterior (A-P) and posterior to anterior (P-A) directions was used to examine 25 patients with schizophrenia (SC) and 37 matched healthy controls (HC). We conducted a functional connectivity analysis using independent component analysis and performed three group comparisons: A-P vs. P-A (all participants), SC vs. HC for the A-P and P-A datasets, and the interaction between phase-encoding direction and participant group. The estimated functional connectivity differed between the two phase-encoding directions in areas that were more extensive than those where signal loss has been reported. Although functional connectivity in the SC group was lower than that in the HC group for both directions, the A-P and P-A conditions did not exhibit the same specific pattern of differences. Further, we observed an interaction between participant group and the phase-encoding direction in the left temporo-parietal junction and left fusiform gyrus. Phase-encoding direction can influence the results of functional connectivity studies. Thus, appropriate selection and documentation of phase-encoding direction will be important in future resting-state fMRI studies. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  17. Direct fitness benefits and kinship of social foraging groups in an Old World tropical babbler

    Science.gov (United States)

    Kaiser, Sara A.; Martin, Thomas E.; Oteyza, Juan C.; Armstad, Connor E.; Fleischer, Robert C.

    2018-01-01

    Molecular studies have revealed that social groups composed mainly of nonrelatives may be widespread in group-living vertebrates, but the benefits favoring such sociality are not well understood. In the Old World, birds often form conspecific foraging groups that are maintained year-round and offspring usually disperse to other social groups. We tested the hypothesis that nonbreeding group members are largely unrelated and gain direct fitness benefits through breeding opportunities (males) and brood parasitism (females) in the tropical gray-throated babbler, Stachyris nigriceps, in Malaysian Borneo. Babblers foraged in social groups containing one or more breeding pairs (median = 8 group members of equal sex ratio), but group members rarely assisted with breeding (9% of 67 breeding pairs had a third helper; exhibiting facultative cooperative breeding). Although 20% of 266 group member dyads were first-order relatives of one or both members of the breeding pairs, 80% were unrelated. Male group members gained direct fitness benefits through extrapair and extra-group paternity (25% of 73 offspring), which was independent of their relatedness to the breeding pair and increased with decreasing group size. In contrast, females did not gain direct fitness benefits through brood parasitism. The low levels of relatedness and helping in social groups suggest that most group members do not gain indirect fitness benefits by helping to raise unrelated offspring. These findings highlight the importance of examining benefits of sociality for unrelated individuals that largely do not help and broaden the direct fitness benefits of group foraging beyond assumed survival benefits.

  18. The Quality of Self, Social, and Directive Memories: Are There Adult Age Group Differences?

    Science.gov (United States)

    Alea, Nicole; Arneaud, Mary Jane; Ali, Sideeka

    2013-01-01

    The quality of functional autobiographical memories was examined in young, middle-aged, and older adult Trinidadians ("N" = 245). Participants wrote about an event that served a self, social, and directive function, and reported on the memory's quality (e.g., significance, vividness, valence, etc.). Across age groups, directive memories…

  19. Clinical observation of Ahmed glaucoma valve implantation for refractory glaucoma by directly puncturing the sclerotic tunnel

    Directory of Open Access Journals (Sweden)

    Zhi-Ke Xu

    2015-02-01

    Full Text Available AIM: To observe the clinic effects and complication of Ahmed glaucoma valve(AGVimplantation in refractory glaucoma by using the 23G syringe needle direct puncture the sclerotic tunnel.METHODS: Forty-four cases(44 eyesof refractory glaucoma underwent AGV implantation by useing the 23G syringe needle direct puncture the sclerotic tunnel. The intraocular pressure(IOP, visual acuity, and complication of post-operation were contrasted with those of pre-operation. RESULTS:The success rate was 84.1%, the mean preoperative IOP in research group was 52.1±10.1mmHg, and the last follow up mean IOP was 15.6±6.9mmHg. Compared with the preoperative visual acuity, 11 eyes increased, 27 eyes had no changes and 6 eyes decreased. The main post-operative complications included shallow anterior chamber(4 eyes, choroidal detachment(3 eyes, drainage tube shift(1 eye, hyphema(6 eyes, drainage tube blockage(1 eye, expulsive choroidal hemorrhage(1 eye, and fiber wrap of drainage tray(5 eyes.CONCLUSION: AGV implantation by direct puncture the sclerotic tunnel is feasible and easy. It avoids of making sclerotic petal and the xenogenic sclera transplanting, simplified the operation technique, prevent the leakage of around tube. The shallow anterior chamber rate is lower. It is an effective procedure for refractory glaucoma.

  20. Costs and cost-effectiveness of different DOT strategies for the treatment of tuberculosis in Pakistan. Directly Observed Treatment.

    Science.gov (United States)

    Khan, M A; Walley, J D; Witter, S N; Imran, A; Safdar, N

    2002-06-01

    An economic study was conducted alongside a clinical trial at three sites in Pakistan to establish the costs and effectiveness of different strategies for implementing directly observed treatment (DOT) for tuberculosis. Patients were randomly allocated to one of three arms: DOTS with direct observation by health workers (at health centres or by community health workers); DOTS with direct observation by family members; and DOTS without direct observation. The clinical trial found no statistically significant difference in cure rate for the different arms. The economic study collected data on the full range of health service costs and patient costs of the different treatment arms. Data were also disaggregated by gender, rural and urban patients, by treatment site and by economic categories, to investigate the costs of the different strategies, their cost-effectiveness and the impact that they might have on patient compliance with treatment. The study found that direct observation by health centre-based health workers was the least cost-effective of the strategies tested (US dollars 310 per case cured). This is an interesting result, as this is the model recommended by the World Health Organization and International Union against Tuberculosis and Lung Disease. Attending health centres daily during the first 2 months generated high patient costs (direct and in terms of time lost), yet cure rates for this group fell below those of the non-observed group (58%, compared with 62%). One factor suggested by this study is that the high costs of attending may be deterring patients, and in particular, economically active patients who have most to lose from the time taken by direct observation. Without stronger evidence of benefits, it is hard to justify the costs to health services and patients that this type of direct observation imposes. The self-administered group came out as most cost-effective (164 dollars per case cured). The community health worker sub-group achieved the

  1. Rhodium-Catalyzed Regioselective C7-Olefination of Indazoles Using an N-Amide Directing Group.

    Science.gov (United States)

    Guo, Lei; Chen, Yanyu; Zhang, Rong; Peng, Qiujun; Xu, Lanting; Pan, Xianhua

    2017-02-01

    A rhodium-catalyzed regioselective C-H olefination of indazole is described. This protocol relies on the use of an efficient and removable N,N-diisopropylcarbamoyl directing group, which offers facile access to C7-olefinated indazoles with high regioselectivity, ample substrate scope and broad functional group tolerance. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Evaluation of the capacity for direct regeneration of maize inbreds of the Lancaster selection group

    Directory of Open Access Journals (Sweden)

    K. V. Derkach

    2013-11-01

    Full Text Available In connection with the necessity of bringing elite maize inbreds of the Lancaster germplasm group, which have potential for cultivation in Ukraine, into the system of genetic tranformation, the aim of this investigation is to identify the ability of maize inbreds of this group to regenerate by direct organogenesis and to determine the optimal mineral basis for their nutritional environment using segments of the node area of shoots. As explantats we used sterile 4-day old seedlings of 4 maize inbreds of Lancaster germplasm and model inbred Chi31 exotic germplasm. The seedlings were obtained by germination of sterile seeds in Petri dishes between two layers of moist sterile filter paper at a temperature of 27 ºC in dark conditions. A single 1 cmlong segment was cut from each from each seedling, running from 0.5 cmbefore the node to 0.5 cmafter the node. A cut was made in each segment of the node in order to create a wounded surface. Explantats were planted in a nutrient environment with mineral bases of MS or N6, modified by the addition of 10 mg/l silver nitrate, 100 mg/l casein hydrolyzate, 690 mg/l L-proline, 30 g/l sucrose, 1.0 mg/l 2,4-dychlorphenoksiacetic acid and 0,1 mg/l abscisic acid. Cultivation was carried out at 25–27 ºC in the light. Direct hemogenesis in this environment on the 14th day of cultivation in vitro reached 100% for each line. This meant that all researched lines of Lancaster germplasm and the model line showed a high capacity for direct regeneration through direct hemogenesis, which does not depend on the composition of the mineral content of their nutritional environment. Callus formation was observed in all genotypes on the 14th day of cultivation in vitro and the extent of its formation increased during the following month of cultivation. The callus formation was observed only at the site of the wounded surface. The calluses were transparent. Although green areas appeared in these calluses, they were

  3. Pd(II)-Catalyzed C–H Functionalizations Directed by Distal Weakly Coordinating Functional Groups

    Science.gov (United States)

    Li, Gang; Wan, Li; Zhang, Guofu; Leow, Dasheng; Spangler, Jillian

    2015-01-01

    Ortho-C(sp2)–H olefination and acetoxylation of broadly useful synthetic building blocks phenylacetyl Weinreb amides, esters, and ketones are developed without installing an additional directing group. The interplay between the distal weak coordination and the ligand-acceleration is crucial for these reactions to proceed under mild conditions. The tolerance of longer distance between the target C–H bonds and the directing functional groups also allows for the functionalizations of more distal C–H bonds in hydrocinnamoyl ketones, Weinreb amides and biphenyl Weinreb amides. Mechanistically, the coordination of these carbonyl groups and the bisdentate amino acid ligand with Pd(II) centers provides further evidence for our early hypothesis that the carbonyl groups of the potassium carboxylate is responsible for the directed C–H activation of carboxylic acids. PMID:25768039

  4. Murai Reaction on Furfural Derivatives Enabled by Removable N,N'-Bidentate Directing Groups.

    Science.gov (United States)

    Pezzetta, Cristofer; Veiros, Luis F; Oble, Julie; Poli, Giovanni

    2017-06-22

    Furfural and related compounds are industrially relevant building blocks obtained from lignocellulosic biomass. To enhance the added value of these renewable resources, a Ru-catalyzed hydrofurylation of alkenes, involving a directed C-H activation at C3 of the furan ring, was developed. A thorough experimental study revealed that a bidentate amino-imine directing group enabled the desired coupling. Removal of the directing group occurred during the purification step, directly releasing the C3-functionalized furfurals. Development of the reaction as well as optimization and scope of the method were described. A mechanism was proposed on the basis of DFT calculations. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Consistency of direct integral estimator for partially observed systems of ordinary differential equations

    NARCIS (Netherlands)

    Vujačić, Ivan; Dattner, Itai

    In this paper we use the sieve framework to prove consistency of the ‘direct integral estimator’ of parameters for partially observed systems of ordinary differential equations, which are commonly used for modeling dynamic processes.

  6. Direct 13C-1H coupling constants in the vinyl group of 1-vinylpyrazoles

    International Nuclear Information System (INIS)

    Afonin, A.V.; Voronov, V.K.; Es'kova, L.A.; Domnina, E.S.; Petrova, E.V.; Zasyad'ko, O.V.

    1987-01-01

    In a continuation of a study of the rotational isomerism of 1-vinylpyrazoles, they studied the direct 13 C- 1 H coupling constants in the vinyl group of 1-vinylpyrazole, 1-vinyl-4-bromopyrazole, 1-vinyl-3-methylpyrazole, 1-vinyl-5-methylpyrazole, 1-vinyl-3,5-dimethylpyrazole, and 1-vinyl-4-nitro-3,5-dimethylpyrazole. The 13 C- 1 H direct coupling constants in the vinyl group of 1-vinylpyrazoles are stereo-specific and vary with change in the conformer ratio

  7. Protocol for the administration of haemofiltration fluids and using patient group electrolytes direction.

    Science.gov (United States)

    Kingston, Diana; Sykes, Siobhan; Raper, Sarah

    2002-01-01

    A patient group direction (PGD) is a specific written instruction for the supply or administration of named medicines in an identified clinical situation The introduction of a PGD must demonstrate a benefit for patients Haemofiltration is widely accepted as the treatment of choice when caring for critically ill patients in acute renal failure on an intensive care unit The haemofiltration PGD improves patient care by providing standardisation in administration of fluids and electrolytes and enabling nurses to respond rapidly to changes in biochemistry during haemofiltration This paper describes the development and implementation of a protocol to enable nurses to administer haemofiltration fluids and electrolytes under a patient group direction.

  8. Pharmacotherapeutic directions of iodine herbal remedies use for different groups of thyroid deseases treatment

    Directory of Open Access Journals (Sweden)

    Інна Миколаївна Владимирова

    2015-11-01

    Full Text Available Recently, the increase of endocrine diseases is observed worldwide. Diabetes mellitus and thyroid gland pathologies are the most widespread. Endocrine diseases can be acute or chronic. In some cases, they are life threatening.There are different reasons of thyroid gland pathologies development. Both poor nutrition and poor quality water use, and unfavorable environmental conditions, including radiation, are among them. Iodine deficiency is determined to be one of the main reasons of these diseases.Aim. Determination of the pharmacotherapeutic directions of iodine herbal remedies use for different groups of thyroid diseases treatment.Methods. Thyroid stimulating action determination (primary screening and model pathology has been carried out by the method of “goiter reaction” in rats at the Central Scientific-Research Laboratory of National University of Pharmacy. Determination of thyroid hormone blood level in rats has been carried out at the Laboratory of Radioactive Endocrinology of the State Institution “Grigoriev Institute for medical Radiology NAMS of Ukraine”.Results. According to the research results generalization, correctness of developed algorithms was confirmed; peculiarities of the influence on pathological processes in thyroid, and prospects of implementation and use of herbs and herbal remedies for thyroid diseases prevention and treatment were determined.Conclusion. Obtained experimental data are actual for the modern medicine, and new scientific research, specifying their place in etiology, pathogenesis and peculiarities of clinical course of many diseases, will improve the efficiency of treatment and prevention of thyroid diseases

  9. Gossip as an alternative for direct observation in games of indirect reciprocity.

    Science.gov (United States)

    Sommerfeld, Ralf D; Krambeck, Hans-Jürgen; Semmann, Dirk; Milinski, Manfred

    2007-10-30

    Communication about social topics is abundant in human societies, and many functions have been attributed to such gossiping. One of these proposed functions is the management of reputations. Reputation by itself has been shown to have a strong influence on cooperation dynamics in games of indirect reciprocity, and this notion helps to explain the observed high level of cooperation in humans. Here we designed a game to test a widespread assumption that gossip functions as a vector for the transmission of social information. This empirical study (with 14 groups of nine students each) focuses on the composition of gossip, information transfer by gossip, and the behavior based on gossip information. We show that gossip has a strong influence on the resulting behavior even when participants have access to the original information (i.e., direct observation) as well as gossip about the same information. Thus, it is evident that gossip has a strong manipulative potential. Furthermore, gossip about cooperative individuals is more positive than gossip about uncooperative individuals, gossip comments transmit social information successfully, and cooperation levels are higher when people encounter positive compared with negative gossip.

  10. One (rating) from many (observations): Factors affecting the individual assessment of voice behavior in groups.

    Science.gov (United States)

    Podsakoff, Nathan P; Maynes, Timothy D; Whiting, Steven W; Podsakoff, Philip M

    2015-07-01

    This article reports an investigation into how individuals form perceptions of overall voice behavior in group contexts. More specifically, the authors examine the effect of the proportion of group members exhibiting voice behavior in the group, the frequency of voice events in the group, and the measurement item referent (group vs. individual) on an individual's ratings of group voice behavior. In addition, the authors examine the effect that measurement item referent has on the magnitude of the relationship observed between an individual's ratings of group voice behavior and perceptions of group performance. Consistent with hypotheses, the results from 1 field study (N = 220) and 1 laboratory experiment (N = 366) indicate that: (a) When group referents were used, raters relied on the frequency of voice events (and not the proportion of group members exhibiting voice) to inform their ratings of voice behavior, whereas the opposite was true when individual-referent items were used, and (b) the magnitude of the relationship between observers' ratings of group voice behavior and their perceptions of group performance was higher when raters used group-referent, as opposed to an individual-referent, items. The authors discuss the implications of their findings for scholars interested in studying behavioral phenomena occurring in teams, groups, and work units in organizational behavior research. (c) 2015 APA, all rights reserved).

  11. Self-administered Versus Directly Observed Once-Weekly Isoniazid and Rifapentine Treatment of Latent Tuberculosis Infection

    Science.gov (United States)

    Belknap, Robert; Holland, David; Feng, Pei-Jean; Millet, Joan-Pau; Caylà, Joan A.; Martinson, Neil A.; Wright, Alicia; Chen, Michael P.; Moro, Ruth N.; Scott, Nigel A.; Arevalo, Bert; Miró, José M.; Villarino, Margarita E.; Weiner, Marc; Borisov, Andrey S.

    2017-01-01

    Background Expanding latent tuberculosis treatment is important to decrease active disease globally. Once-weekly isoniazid and rifapentine for 12 doses is effective but limited by requiring direct observation. Objective To compare treatment completion and safety of once-weekly isoniazid and rifapentine by self-administration versus direct observation. Design An open-label, phase 4 randomized clinical trial designed as a noninferiority study with a 15% margin. Seventy-five percent or more of study patients were enrolled from the United States for a prespecified subgroup analysis. (ClinicalTrials.gov: NCT01582711) Setting Outpatient tuberculosis clinics in the United States, Spain, Hong Kong, and South Africa. Participants 1002 adults (aged ≥18 years) recommended for treatment of latent tuberculosis infection. Intervention Participants received once-weekly isoniazid and rifapentine by direct observation, self-administration with monthly monitoring, or self-administration with weekly text message reminders and monthly monitoring. Measurements The primary outcome was treatment completion, defined as 11 or more doses within 16 weeks and measured using clinical documentation and pill counts for direct observation, and self-reports, pill counts, and medication event–monitoring devices for self-administration. The main secondary outcome was adverse events. Results Median age was 36 years, 48% of participants were women, and 77% were enrolled at the U.S. sites. Treatment completion was 87.2% (95% CI, 83.1% to 90.5%) in the direct-observation group, 74.0% (CI, 68.9% to 78.6%) in the self-administration group, and 76.4% (CI, 71.3% to 80.8%) in the self-administration–with–reminders group. In the United States, treatment completion was 85.4% (CI, 80.4% to 89.4%), 77.9% (CI, 72.7% to 82.6%), and 76.7% (CI, 70.9% to 81.7%), respectively. Self-administered therapy without reminders was noninferior to direct observation in the United States; no other comparisons met

  12. Effects of walker gender and observer gender on biological motion walking direction discrimination.

    Science.gov (United States)

    Yang, Xiaoying; Cai, Peng; Jiang, Yi

    2014-09-01

    The ability to recognize the movements of other biological entities, such as whether a person is walking toward you, is essential for survival and social interaction. Previous studies have shown that the visual system is particularly sensitive to approaching biological motion. In this study, we examined whether the gender of walkers and observers influenced the walking direction discrimination of approaching point-light walkers in fine granularity. The observers were presented a walker who walked in different directions and were asked to quickly judge the walking direction (left or right). The results showed that the observers demonstrated worse direction discrimination when the walker was depicted as male than when the walker was depicted as female, probably because the observers tended to perceive the male walkers as walking straight ahead. Intriguingly, male observers performed better than female observers at judging the walking directions of female walkers but not those of male walkers, a result indicating perceptual advantage with evolutionary significance. These findings provide strong evidence that the gender of walkers and observers modulates biological motion perception and that an adaptive perceptual mechanism exists in the visual system to facilitate the survival of social organisms. © 2014 The Institute of Psychology, Chinese Academy of Sciences and Wiley Publishing Asia Pty Ltd.

  13. Direct fitness of group living mammals varies with breeding strategy, climate and fitness estimates.

    Science.gov (United States)

    Ebensperger, Luis A; Rivera, Daniela S; Hayes, Loren D

    2012-09-01

    1. Understanding how variation in fitness relates to variation in group living remains critical to determine whether this major aspect of social behaviour is currently adaptive. 2. Available evidence in social mammals aimed to examine this issue remains controversial. Studies show positive (i.e. potentially adaptive), neutral or even negative fitness effects of group living. 3. Attempts to explain this variation rely on intrinsic and extrinsic factors to social groups. Thus, relatively more positive fitness effects are predicted in singularly breeding as opposed to plural breeding species. Fitness effects of sociality in turn may depend on ecological conditions (i.e. extrinsic factors) that influence associated benefits and costs. 4. We used meta-analytic tools to review how breeding strategy or ecological conditions influence the effect size associated with direct fitness-sociality relationships reported in the mammalian literature. Additionally, we determined how taxonomic affiliation of species studied, different fitness and sociality measures used, and major climatic conditions of study sites explained any variation in direct fitness effect size. 5. We found group living had modest, yet positive effects on direct fitness. This generally adaptive scenario was contingent not only upon breeding strategy and climate of study sites, but also on fitness measures examined. Thus, positive and significant effects characterized singular as opposed to plural breeding strategies. 6. We found more positive fitness effects on studies conducted in tropical as opposed to temperate or arid climates. More positive and significant effects were noted on studies that relied on group fecundity, male fecundity and offspring survival as measures of fitness. 7. To conclude, direct fitness consequences of mammalian group living are driven by interspecific differences in breeding strategy and climate conditions. Other factors not examined in this study, namely individual variation in

  14. Palladium(II)-catalyzed ortho-olefination of arenes applying sulfoxides as remote directing groups.

    Science.gov (United States)

    Wang, Binjie; Shen, Chuang; Yao, Jinzhong; Yin, Hong; Zhang, Yuhong

    2014-01-03

    A novel palladium-catalyzed ortho-C(sp(2))-H olefination protocol has been developed by the use of sulfoxide as the directing group. Importantly, relatively remote coordination can be accessed to achieve the ortho olefination of benzyl, 2-arylethyl, and 3-arylpropenyl sulfoxide substrates, and the olefinated sulfoxide can be easily transformed to other functionalities.

  15. Some New Lie Symmetry Groups of Differential-Difference Equations Obtained from a Simple Direct Method

    International Nuclear Information System (INIS)

    Zhi Hongyan

    2009-01-01

    In this paper, based on the symbolic computing system Maple, the direct method for Lie symmetry groups presented by Sen-Yue Lou [J. Phys. A: Math. Gen. 38 (2005) L129] is extended from the continuous differential equations to the differential-difference equations. With the extended method, we study the well-known differential-difference KP equation, KZ equation and (2+1)-dimensional ANNV system, and both the Lie point symmetry groups and the non-Lie symmetry groups are obtained.

  16. The visibility function and its effect on the observed characteristics of sunspot groups. 1

    International Nuclear Information System (INIS)

    Kopecky, M.; Kuklin, G.V.; Starkova, I.P.

    1985-01-01

    The paper is an introductory study to a series dealing with the visibility function, the function of foreshortening of sunspot group areas, and with the effect of these functions on the results of the statistical processing of observations, which has to be taken into account in interpreting the results. A ''diagram of observational conditions'' is described, which enables a number of statistical problems of sunspot groups on the rotating Sun to be solved by computer modelling or by graphical methods. Examples are given of the use of this diagram in studying the distribution of the observed lifetime of sunspot groups with a given actual lifetime, of the decrease in the number of sunspot groups towards the limb of the solar disc, of the east-west asymmetry of sunspot group appearance and disappearance. (author)

  17. Gamblers Anonymous in Israel: a participant observation study of a self-help group.

    Science.gov (United States)

    Cromer, G

    1978-10-01

    This participant observation study of the first Gamblers Anonymous group in Israel is designed to show (1) the ways in which the group helps it members rehabilitate themselves, (2) the three stages through which they must go in order to ensure success, and (3) the reason why some participants fail to do so. The article concludes with a number of observations concerning the extent of gambling in Israel and the different ways that should be developed for dealing with the problem.

  18. Treatment of tuberculosis in a rural area of Haiti: directly observed and non-observed regimens. The experience of H pital Albert Schweitzer.

    Science.gov (United States)

    Ollé-Goig, J E; Alvarez, J

    2001-02-01

    Artibonite Valley, a rural area in Haiti. To evaluate a tuberculosis control program in rural Haiti and to compare two strategies for treatment implemented in two areas that were not chosen at random: treatment delivered at the patients' homes observed by former tuberculosis patients (DOT), and non observed treatment (non-DOT). Retrospective analysis of the clinical records of adult patients diagnosed with tuberculosis at H pital Albert Schweitzer in Deschapelles, Haiti, during 1994-1995. There were 143 patients in the non-DOT group and 138 patients in the DOT group. The results of treatment were significantly different: in the non-DOT group 29% defaulted, 12% died and 58% had a successful outcome; in the DOT group 7% defaulted (P < 0.01), 4% died (P = 0.01) and 87% had a successful outcome (P < 0.01). These differences are also significant when considering only human immunodeficiency virus (HIV) infected patients (defaulted P < 0.01; died P = 0.09; successful outcome P < 0.01). Delivering treatment in patients' homes with direct observation by former tuberculosis patients can achieve good results, even in an area of extreme poverty and high rates of HIV infection. In this population the number of patients who are able to complete their treatment without observed administration is far from optimal.

  19. Measurement Error Correction Formula for Cluster-Level Group Differences in Cluster Randomized and Observational Studies

    Science.gov (United States)

    Cho, Sun-Joo; Preacher, Kristopher J.

    2016-01-01

    Multilevel modeling (MLM) is frequently used to detect cluster-level group differences in cluster randomized trial and observational studies. Group differences on the outcomes (posttest scores) are detected by controlling for the covariate (pretest scores) as a proxy variable for unobserved factors that predict future attributes. The pretest and…

  20. Sociometric Status and Social Drinking: Observations of Modelling and Persuasion in Young Adult Peer Groups

    Science.gov (United States)

    Bot, Sander M.; Engels, Rutger C. M. E.; Knibbe, Ronald A.; Meeus, Wim H. J.

    2007-01-01

    Because young adult drinking occurs primarily in peer groups, this should be taken into account when studying influences on drinking behaviour. This paper aimed to assess influences on drinking by observing existing peer groups in a naturalistic setting. We first analysed the basic levels at which two types of influence take place. The first,…

  1. SUZAKU OBSERVATIONS OF THE X-RAY BRIGHTEST FOSSIL GROUP ESO 3060170

    International Nuclear Information System (INIS)

    Su, Yuanyuan; White, Raymond E. III; Miller, Eric D.

    2013-01-01

    'Fossil' galaxy groups, each dominated by a relatively isolated giant elliptical galaxy, have many properties intermediate between groups and clusters of galaxies. We used the Suzaku X-ray observatory to observe the X-ray brightest fossil group, ESO 3060170, out to R 200 , in order to better elucidate the relation between fossil groups, normal groups, and clusters. We determined the intragroup gas temperature, density, and metal abundance distributions and derived the entropy, pressure, and mass profiles for this group. The entropy and pressure profiles in the outer regions are flatter than in simulated clusters, similar to what is seen in observations of massive clusters. This may indicate that the gas is clumpy and/or the gas has been redistributed. Assuming hydrostatic equilibrium, the total mass is estimated to be ∼1.7 × 10 14 M ☉ within a radius R 200 of ∼1.15 Mpc, with an enclosed baryon mass fraction of 0.13. The integrated iron mass-to-light ratio of this fossil group is larger than in most groups and comparable to those of clusters, indicating that this fossil group has retained the bulk of its metals. A galaxy luminosity density map on a scale of 25 Mpc shows that this fossil group resides in a relatively isolated environment, unlike the filamentary structures in which typical groups and clusters are embedded

  2. An observational study of cross-cultural communication in short-term, diverse professional learning groups

    International Nuclear Information System (INIS)

    Robinson, Leslie; Hogg, Peter; Higgins, Robert

    2014-01-01

    This paper reports the evaluation of a European funded 3-week summer school which took place in 2013 involving 60 staff and students from five universities. The evaluation looked at one group in detail using a qualitative approach to consider whether students and teachers can work together in multicultural groups in order to achieve their goal. Method: One group was observed during 2 two-hour sessions of group activity; at the beginning and end of the summer school task. Video data was analysed using the Rapport Management framework, a model of cross-cultural communication, to determine what motivated this group's interactions. Results: As the group's deadline became imminent ‘face-threatening acts’ (FTAs) were more apparent. These were tolerated in this group because of the development of a strong social bond. There was inequity in participation with members of the group falling into either high- or low-involvement categories. This was also well-tolerated but meant some students may not have gained as much from the experience. The group lacked guidance on managing group dynamics. Conclusion: Cultural differences in communication were not the main threat to multi-cultural working groups. Potential problems can arise from failing to provide the group with a framework for project and team management. An emphasis on ground rules and the allocation of formal roles is important as is the encouragement of socialisation which supports the group during challenging times

  3. Decentralisation of directly observed treatment in a large African city: evaluation of the experience of Djibouti.

    Science.gov (United States)

    Bernatas, J J; Ali, I M; Ismaël, H A; Matan, A B; Aboubakar, I H

    2003-08-01

    Decentralisation of directly observed treatment (DOT) for tuberculosis patients in three public centres in Djibouti city from April 2000. To evaluate decentralisation based on the success rate by site of treatment and according to certain critical variables. Comparative evaluation of the success rate of smear-positive patients followed in all treatment centres from 1 May 2000 to 31 March 2001. The success rate was 58% for the main centre, Centre Paul Faure, and 81% for all the peripheral centres together (P 0.05). Age under 20 years, female sex and treatment centre were factors linked to success. After stratification, sex was shown to be the confounding variable. Multivariate analysis shows that non-Djibouti nationality is related to treatment success (P = 0.02). In the groups of established and new centres, there is an inverse linear relationship between success rate and workload, with greater capacity in the established centres. Urban decentralisation of DOT increases the chances of treatment success among smear-positive patients. Another centre for supervised treatment needs to be created in one of the public health centres in Djibouti city.

  4. Direct observation of free-exciton thermalization in quantum-well structures

    DEFF Research Database (Denmark)

    Umlauff, M.; Hoffmann, J.; Kalt, H.

    1998-01-01

    We report on a direct observation of free-exciton thermalization in quantum-well structures. A narrow energy distribution of free 1s excitons is created in ZnSe-based quantum wells by emission of one LO phonon after optical excitation of the continuum stales with picosecond laser pulses. The subs......We report on a direct observation of free-exciton thermalization in quantum-well structures. A narrow energy distribution of free 1s excitons is created in ZnSe-based quantum wells by emission of one LO phonon after optical excitation of the continuum stales with picosecond laser pulses...

  5. Two dimentional lattice vibrations from direct product representations of symmetry groups

    Directory of Open Access Journals (Sweden)

    J. N. Boyd

    1983-01-01

    two dimensional crystals. First, the Born cyclic condition is applied to a double chain composed of coupled linear lattices to obtain a cylindrical arrangement. Then the quadratic Lagrangian function for the system is written in matrix notation. The Lagrangian is diagonalized to yield the natural frequencies of the system. The transformation to achieve the diagonalization was obtained from group theorectic considerations. Next, the techniques developed for the double chain are applied to a square lattice. The square lattice is transformed into the toroidal Ising model. The direct product nature of the symmetry group of the torus reveals the transformation to diagonalize the Lagrangian for the Ising model, and the natural frequencies for the principal directions in the model are obtained in closed form.

  6. Competition between direct interaction and Kondo effect: Renormalization-group approach

    International Nuclear Information System (INIS)

    Allub, R.

    1988-03-01

    Via the Wilson renormalization-group approach, the effect of the competition between direct interaction (J L ) and Kondo coupling is studied, in the magnetic susceptibility of a model with two different magnetic impurities. For the ferromagnetic interaction (J L > 0) between the localized impurities, we find a magnetic ground state and a divergent susceptibility at low temperatures. For (J L < 0), two different Kondo temperatures and a non-magnetic ground state are distinguished. (author). 12 refs, 1 fig

  7. Direct Observation of Clinical Skills Feedback Scale: Development and Validity Evidence.

    Science.gov (United States)

    Halman, Samantha; Dudek, Nancy; Wood, Timothy; Pugh, Debra; Touchie, Claire; McAleer, Sean; Humphrey-Murto, Susan

    2016-01-01

    Construct: This article describes the development and validity evidence behind a new rating scale to assess feedback quality in the clinical workplace. Competency-based medical education has mandated a shift to learner-centeredness, authentic observation, and frequent formative assessments with a focus on the delivery of effective feedback. Because feedback has been shown to be of variable quality and effectiveness, an assessment of feedback quality in the workplace is important to ensure we are providing trainees with optimal learning opportunities. The purposes of this project were to develop a rating scale for the quality of verbal feedback in the workplace (the Direct Observation of Clinical Skills Feedback Scale [DOCS-FBS]) and to gather validity evidence for its use. Two panels of experts (local and national) took part in a nominal group technique to identify features of high-quality feedback. Through multiple iterations and review, 9 features were developed into the DOCS-FBS. Four rater types (residents n = 21, medical students n = 8, faculty n = 12, and educators n = 12) used the DOCS-FBS to rate videotaped feedback encounters of variable quality. The psychometric properties of the scale were determined using a generalizability analysis. Participants also completed a survey to gather data on a 5-point Likert scale to inform the ease of use, clarity, knowledge acquisition, and acceptability of the scale. Mean video ratings ranged from 1.38 to 2.96 out of 3 and followed the intended pattern suggesting that the tool allowed raters to distinguish between examples of higher and lower quality feedback. There were no significant differences between rater type (range = 2.36-2.49), suggesting that all groups of raters used the tool in the same way. The generalizability coefficients for the scale ranged from 0.97 to 0.99. Item-total correlations were all above 0.80, suggesting some redundancy in items. Participants found the scale easy to use (M = 4.31/5) and clear

  8. Direct observation of labelled aerosols deposition into the respiratory tract of the rat

    International Nuclear Information System (INIS)

    Duport, P.

    1977-01-01

    With a new process the deposition of labelled aerosols into the respiratory tract of the rat can be directly observed. A qualitative convergence between the theoretical retention and real retention for a large scale of aerosol dimensions, is found out [fr

  9. Direct observation of surface reconstruction and termination on a complex metal oxide catalyst by electron microscopy

    KAUST Repository

    Zhu, Yihan

    2012-03-19

    On the surface: The surface reconstruction of an MoVTeO complex metal oxide catalyst was observed directly by various electron microscopic techniques and the results explain the puzzling catalytic behavior. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Direct AFM observation of an opening event of a DNA cuboid constructed via a prism structure.

    Science.gov (United States)

    Endo, Masayuki; Hidaka, Kumi; Sugiyama, Hiroshi

    2011-04-07

    A cuboid structure was constructed using a DNA origami design based on a square prism structure. The structure was characterized by atomic force microscopy (AFM) and dynamic light scattering. The real-time opening event of the cuboid was directly observed by high-speed AFM.

  11. Direct Observation of Sub-100 fs Mobile Charge Generation in a Polymer-Fullerene Film

    DEFF Research Database (Denmark)

    Cooke, D. G.; Krebs, Frederik C; Jepsen, Peter Uhd

    2012-01-01

    The formation of mobile charges in a roll-to-roll processed poly-3-hexylthiophene-fullerene bulk heterojunction film is observed directly by using transient terahertz spectroscopy with sub-100 fs temporal resolution. The transient terahertz ac conductivity reveals that 20% of the incident pump...

  12. Direct observation of short-circuit diffusion during the formation of a single cupric oxide nanowire

    International Nuclear Information System (INIS)

    Cheng, C-L; Ma, Y-R; Chou, M H; Huang, C Y; Yeh, V; Wu, S Y

    2007-01-01

    Short-circuit diffusion was observed in a single CuO nanowire synthesized using a thermal oxidation method. The confocal Raman spectra of a single CuO nanowire permit direct observation of the nature of an individual CuO nanowire. The parameter order obtained from the inverse Raman B g 2 peak linewidth results in the length dependence of the linewidth and a short-circuit diffusion length of 3.3 μm. The observed structural information is also consistent with the energy dispersive x-ray spectroscopic mapping. The results confirm that the growth of CuO nanowires occurs through the short-circuit diffusion mechanism

  13. Analysis of multidimensional difference-of-Gaussians filters in terms of directly observable parameters.

    Science.gov (United States)

    Cope, Davis; Blakeslee, Barbara; McCourt, Mark E

    2013-05-01

    The difference-of-Gaussians (DOG) filter is a widely used model for the receptive field of neurons in the retina and lateral geniculate nucleus (LGN) and is a potential model in general for responses modulated by an excitatory center with an inhibitory surrounding region. A DOG filter is defined by three standard parameters: the center and surround sigmas (which define the variance of the radially symmetric Gaussians) and the balance (which defines the linear combination of the two Gaussians). These parameters are not directly observable and are typically determined by nonlinear parameter estimation methods applied to the frequency response function. DOG filters show both low-pass (optimal response at zero frequency) and bandpass (optimal response at a nonzero frequency) behavior. This paper reformulates the DOG filter in terms of a directly observable parameter, the zero-crossing radius, and two new (but not directly observable) parameters. In the two-dimensional parameter space, the exact region corresponding to bandpass behavior is determined. A detailed description of the frequency response characteristics of the DOG filter is obtained. It is also found that the directly observable optimal frequency and optimal gain (the ratio of the response at optimal frequency to the response at zero frequency) provide an alternate coordinate system for the bandpass region. Altogether, the DOG filter and its three standard implicit parameters can be determined by three directly observable values. The two-dimensional bandpass region is a potential tool for the analysis of populations of DOG filters (for example, populations of neurons in the retina or LGN), because the clustering of points in this parameter space may indicate an underlying organizational principle. This paper concentrates on circular Gaussians, but the results generalize to multidimensional radially symmetric Gaussians and are given as an appendix.

  14. Molecular typing for blood group antigens within 40 minutes by direct PCR from plasma or serum

    Science.gov (United States)

    Wagner, Franz Friedrich; Flegel, Willy Albert; Bittner, Rita; Döscher, Andrea

    2016-01-01

    Determining blood group antigens by serological methods may be unreliable in certain situations, such as in patients after chronic or massive transfusion. Red cell genotyping offers a complementary approach, but current methods may take much longer than conventional serological typing, limiting their utility in urgent situations. To narrow this gap, we devised a rapid method using direct polymerase chain reaction (PCR) amplification while avoiding the DNA extraction step. DNA was amplified by PCR directly from plasma or serum of blood donors followed by a melting curve analysis in a capillary rapid-cycle PCR assay. We evaluated the single nucleotide polymorphisms underlying the clinically relevant Fya, Fyb, Jka and Jkb antigens, with our analysis being completed within 40 min of receiving a plasma or serum sample. The positive predictive value was 100% and the negative predictive value at least 84%. Direct PCR with melting point analysis allowed faster red cell genotyping to predict blood group antigens than any previous molecular method. Our assay may be used as a screening tool with subsequent confirmatory testing, within the limitations of the false-negative rate. With fast turnaround times, the rapid-cycle PCR assay may eventually be developed and applied to red cell genotyping in the hospital setting. PMID:27991657

  15. Direct observation of cascade defect formation at low temperatures in ion-irradiated metals

    International Nuclear Information System (INIS)

    Muroga, T.; Hirooka, K.; Ishino, S.

    1984-01-01

    Direct transmission electron microscopy observations of cascade defect formation have been carried out in gold, Type 316 stainless steel, and aluminum irradiated by Al + , Ar - , and Xe + ions with energies between 80 and 400 keV. By utilizing a link of an ion accelerator to an electron microscope, in situ observations at low temperature (-150 0 C) have become possible. In gold, subcascade structures are clearly observed in all cases. Obvious dependence on projectile mass and energy is observed for cascade structure and vacancy clustering efficiency in gold and for defect visibility in aluminum and Type 316 stainless steel. A computer simulation calculation using MARLOWE shows subcascade distributions a little smaller in size and larger in number than the present observation

  16. THE STRUCTURE OF A SELF-GRAVITATING PROTOPLANETARY DISK AND ITS IMPLICATIONS FOR DIRECT IMAGING OBSERVATIONS

    International Nuclear Information System (INIS)

    Muto, Takayuki

    2011-01-01

    We consider the effects of self-gravity on the hydrostatic balance in the vertical direction of a gaseous disk and discuss the possible signature of the self-gravity that may be captured by direct imaging observations of protoplanetary disks in the future. In this paper, we consider a vertically isothermal disk in order to isolate the effects of self-gravity. The specific disk model we consider in this paper is the one with a radial surface density gap, at which the Toomre's Q-parameter of the disk varies rapidly in the radial direction. We calculate the vertical structure of the disk including the effects of self-gravity. We then calculate the scattered light and the dust thermal emission. We find that if the disk is massive enough and the effects of self-gravity come into play, a weak bump-like structure at the gap edge appears in the near-infrared (NIR) scattered light, while no such bump-like structure is seen in the submillimeter (sub-mm) dust continuum image. The appearance of the bump is caused by the variation of the height of the surface in the NIR wavelength. If such a bump-like feature is detected in future direct imaging observations, combined with sub-mm observations, it will give us useful information about the physical states of the disk.

  17. Teaching Play Skills to Children with Autism through Video Modeling: Small Group Arrangement and Observational Learning

    Science.gov (United States)

    Ozen, Arzu; Batu, Sema; Birkan, Binyamin

    2012-01-01

    The purpose of the present study was to examine if video modeling was an effective way of teaching sociodramatic play skills to individuals with autism in a small group arrangement. Besides maintenance, observational learning and social validation data were collected. Three 9 year old boys with autism participated in the study. Multiple probe…

  18. Development of the Teacher Feedback Observation Scheme: evaluating the quality of feedback in peer groups

    NARCIS (Netherlands)

    Thurlings, Marieke; Vermeulen, Marjan; Kreijns, Karel; Bastiaens, Theo; Stijnen, Sjef

    2018-01-01

    Research suggests that feedback is an essential element in learning. This study focuses on feedback that teachers provide in reciprocal peer groups to improve their performance in the classroom. The Teacher Feedback Observation Scheme (TFOS) was developed to identify feedback patterns, which

  19. Renormalization group running of fermion observables in an extended non-supersymmetric SO(10) model

    Energy Technology Data Exchange (ETDEWEB)

    Meloni, Davide [Dipartimento di Matematica e Fisica, Università di Roma Tre,Via della Vasca Navale 84, 00146 Rome (Italy); Ohlsson, Tommy; Riad, Stella [Department of Physics, School of Engineering Sciences,KTH Royal Institute of Technology - AlbaNova University Center,Roslagstullsbacken 21, 106 91 Stockholm (Sweden)

    2017-03-08

    We investigate the renormalization group evolution of fermion masses, mixings and quartic scalar Higgs self-couplings in an extended non-supersymmetric SO(10) model, where the Higgs sector contains the 10{sub H}, 120{sub H}, and 126{sub H} representations. The group SO(10) is spontaneously broken at the GUT scale to the Pati-Salam group and subsequently to the Standard Model (SM) at an intermediate scale M{sub I}. We explicitly take into account the effects of the change of gauge groups in the evolution. In particular, we derive the renormalization group equations for the different Yukawa couplings. We find that the computed physical fermion observables can be successfully matched to the experimental measured values at the electroweak scale. Using the same Yukawa couplings at the GUT scale, the measured values of the fermion observables cannot be reproduced with a SM-like evolution, leading to differences in the numerical values up to around 80%. Furthermore, a similar evolution can be performed for a minimal SO(10) model, where the Higgs sector consists of the 10{sub H} and 126{sub H} representations only, showing an equally good potential to describe the low-energy fermion observables. Finally, for both the extended and the minimal SO(10) models, we present predictions for the three Dirac and Majorana CP-violating phases as well as three effective neutrino mass parameters.

  20. Direct atomic force microscopy observation of DNA tile crystal growth at the single-molecule level.

    Science.gov (United States)

    Evans, Constantine G; Hariadi, Rizal F; Winfree, Erik

    2012-06-27

    While the theoretical implications of models of DNA tile self-assembly have been extensively researched and such models have been used to design DNA tile systems for use in experiments, there has been little research testing the fundamental assumptions of those models. In this paper, we use direct observation of individual tile attachments and detachments of two DNA tile systems on a mica surface imaged with an atomic force microscope (AFM) to compile statistics of tile attachments and detachments. We show that these statistics fit the widely used kinetic Tile Assembly Model and demonstrate AFM movies as a viable technique for directly investigating DNA tile systems during growth rather than after assembly.

  1. The Hawthorne effect in direct observation research with physicians and patients.

    Science.gov (United States)

    Goodwin, Meredith A; Stange, Kurt C; Zyzanski, Stephen J; Crabtree, Benjamin F; Borawski, Elaine A; Flocke, Susan A

    2017-12-01

    This study examines the degree to which a "Hawthorne effect" alters outpatient-visit content. Trained research nurses directly observed 4454 visits to 138 family physicians. Multiple data sources were used to examine the Hawthorne effect including differences in medical record documentation for observed visits and the prior visit by the same patient, time use during visits on the first versus the second observation day of each physician, and report by the patient, physician, and observer of the effect of observation. Visits on the first versus the second observation day were longer by an average of 1 minute (P effect of the observer on the interaction was reported by 74% of patients and 55% of physicians. Most of those that reported an affect indicated it was slight. Patients with non-White race, lower-educational level, and poorer health were more likely to report being affected by the observer. In a study that was designed to minimize the Hawthorne effect, the presence of an observer had little effect on most patient-physician visits but appeared to at least slightly effect a subgroup of vulnerable patients. © 2017 John Wiley & Sons, Ltd.

  2. Directly Observing Micelle Fusion and Growth in Solution by Liquid-Cell Transmission Electron Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Parent, Lucas R. [Department; amp, Biochemistry, University of California, San Diego, La Jolla, California 92093, United States; Bakalis, Evangelos [Dipartimento; Ramírez-Hernández, Abelardo [Materials; Institute; Kammeyer, Jacquelin K. [Department; amp, Biochemistry, University of California, San Diego, La Jolla, California 92093, United States; Park, Chiwoo [Department; de Pablo, Juan [Materials; Institute; Zerbetto, Francesco [Dipartimento; Patterson, Joseph P. [Department; amp, Biochemistry, University of California, San Diego, La Jolla, California 92093, United States; Laboratory; Gianneschi, Nathan C. [Department; amp, Biochemistry, University of California, San Diego, La Jolla, California 92093, United States

    2017-11-16

    Amphiphilic small molecules and polymers form commonplace nanoscale macromolecular compartments and bilayers, and as such are truly essential components in all cells and in many cellular processes. The nature of these architectures, including their formation, phase changes, and stimuli-response behaviors, is necessary for the most basic functions of life, and over the past half-century, these natural micellar structures have inspired a vast diversity of industrial products, from biomedicines to detergents, lubricants, and coatings. The importance of these materials and their ubiquity have made them the subject of intense investigation regarding their nanoscale dynamics with increasing interest in obtaining sufficient temporal and spatial resolution to directly observe nanoscale processes. However, the vast majority of experimental methods involve either bulk-averaging techniques including light, neutron, and X-ray scattering, or are static in nature including even the most advanced cryogenic transmission electron microscopy techniques. Here, we employ in situ liquid-cell transmission electron microscopy (LCTEM) to directly observe the evolution of individual amphiphilic block copolymer micellar nanoparticles in solution, in real time with nanometer spatial resolution. These observations, made on a proof-of-concept bioconjugate polymer amphiphile, revealed growth and evolution occurring by unimer addition processes and by particle-particle collision-and-fusion events. The experimental approach, combining direct LCTEM observation, quantitative analysis of LCTEM data, and correlated in silico simulations, provides a unique view of solvated soft matter nanoassemblies as they morph and evolve in time and space, enabling us to capture these phenomena in solution.

  3. New reconstruction of the sunspot group numbers since 1739 using direct calibration and "backbone" methods

    Science.gov (United States)

    Chatzistergos, Theodosios; Usoskin, Ilya G.; Kovaltsov, Gennady A.; Krivova, Natalie A.; Solanki, Sami K.

    2017-06-01

    Context. The group sunspot number (GSN) series constitute the longest instrumental astronomical database providing information on solar activity. This database is a compilation of observations by many individual observers, and their inter-calibration has usually been performed using linear rescaling. There are multiple published series that show different long-term trends for solar activity. Aims: We aim at producing a GSN series, with a non-linear non-parametric calibration. The only underlying assumptions are that the differences between the various series are due to different acuity thresholds of the observers, and that the threshold of each observer remains constant throughout the observing period. Methods: We used a daisy chain process with backbone (BB) observers and calibrated all overlapping observers to them. We performed the calibration of each individual observer with a probability distribution function (PDF) matrix constructed considering all daily values for the overlapping period with the BB. The calibration of the BBs was carried out in a similar manner. The final series was constructed by merging different BB series. We modelled the propagation of errors straightforwardly with Monte Carlo simulations. A potential bias due to the selection of BBs was investigated and the effect was shown to lie within the 1σ interval of the produced series. The exact selection of the reference period was shown to have a rather small effect on our calibration as well. Results: The final series extends back to 1739 and includes data from 314 observers. This series suggests moderate activity during the 18th and 19th century, which is significantly lower than the high level of solar activity predicted by other recent reconstructions applying linear regressions. Conclusions: The new series provides a robust reconstruction, based on modern and non-parametric methods, of sunspot group numbers since 1739, and it confirms the existence of the modern grand maximum of solar

  4. Evidence for the social role theory of stereotype content: observations of groups' roles shape stereotypes.

    Science.gov (United States)

    Koenig, Anne M; Eagly, Alice H

    2014-09-01

    In applying social role theory to account for the content of a wide range of stereotypes, this research tests the proposition that observations of groups' roles determine stereotype content (Eagly & Wood, 2012). In a novel test of how stereotypes can develop from observations, preliminary research collected participants' beliefs about the occupational roles (e.g., lawyer, teacher, fast food worker, chief executive officer, store clerk, manager) in which members of social groups (e.g., Black women, Hispanics, White men, the rich, senior citizens, high school dropouts) are overrepresented relative to their numbers in the general population. These beliefs about groups' typical occupational roles proved to be generally accurate when evaluated in relation to data from the Bureau of Labor Statistics. Then, correlational studies predicted participants' stereotypes of social groups from the attributes ascribed to group members' typical occupational roles (Studies 1a, 1b, and 1c), the behaviors associated with those roles (Study 2), and the occupational interest profile of the roles (Study 3). As predicted by social role theory, beliefs about the attributes of groups' typical roles were strongly related to group stereotypes on both communion and agency/competence. In addition, an experimental study (Study 4) demonstrated that when social groups were described with changes to their typical social roles in the future, their projected stereotypes were more influenced by these future roles than by their current group stereotypes, thus supporting social role theory's predictions about stereotype change. Discussion considers the implications of these findings for stereotype change and the relation of social role theory to other theories of stereotype content. 2014 APA, all rights reserved

  5. Concordance of chart and billing data with direct observation in dental practice.

    Science.gov (United States)

    Demko, Catherine A; Victoroff, Kristin Zakariasen; Wotman, Stephen

    2008-10-01

    The commonly used methods of chart review, billing data summaries and practitioner self-reporting have not been examined for their ability to validly and reliably represent time use and service delivery in routine dental practice. A more thorough investigation of these data sources would provide insight into the appropriateness of each approach for measuring various clinical behaviors. The aim of this study was to assess the validity of commonly used methods such as dental chart review, billing data, or practitioner self-report compared with a 'gold standard' of information derived from direct observation of routine dental visits. A team of trained dental hygienists directly observed 3751 patient visits in 120 dental practices and recorded the behaviors and procedures performed by dentists and hygienists during patient contact time. Following each visit, charts and billing records were reviewed for the performed and billed procedures. Dental providers characterized their frequency of preventive service delivery through self-administered surveys. We standardized the observation and abstraction methods to obtain optimal measures from each of the multiple data sources. Multi-rater kappa coefficients were computed to monitor standardization, while sensitivity, specificity, and kappa coefficients were calculated to compare the various data sources with direct observation. Chart audits were more sensitive than billing data for all observed procedures and demonstrated higher agreement with directly observed data. Chart and billing records were not sensitive for several prevention-related tasks (oral cancer screening and oral hygiene instruction). Provider self-reports of preventive behaviors were always over-estimated compared with direct observation. Inter-method reliability kappa coefficients for 13 procedures ranged from 0.197 to 0.952. These concordance findings suggest that strengths and weaknesses of data collection sources should be considered when investigating

  6. Observer perceptions of moral obligations in groups with a history of victimization.

    Science.gov (United States)

    Warner, Ruth H; Branscombe, Nyla R

    2012-07-01

    The authors investigated when observers assign contemporary group members moral obligations based on their group's victimization history. In Experiment 1, Americans perceived Israelis as obligated to help Sudanese genocide victims and as guiltworthy for not helping if reminded of the Holocaust and its descendants were linked to this history. In Experiment 2, participants perceived Israelis as more obligated to help and guiltworthy for not helping when the Holocaust was presented as a unique victimization event compared with when genocide was presented as pervasive. Experiments 3 and 4 replicated the effects of Experiment 1 with Cambodians as the victimized group. Experiment 5 demonstrated that participants perceived Cambodians as having more obligations under high just world threat compared with low just world threat. Perceiving victimized groups as incurring obligations is one just world restoration method of providing meaning to collective injustice.

  7. Direct Observation of Individual Charges and Their Dynamics on Graphene by Low-Energy Electron Holography.

    Science.gov (United States)

    Latychevskaia, Tatiana; Wicki, Flavio; Longchamp, Jean-Nicolas; Escher, Conrad; Fink, Hans-Werner

    2016-09-14

    Visualizing individual charges confined to molecules and observing their dynamics with high spatial resolution is a challenge for advancing various fields in science, ranging from mesoscopic physics to electron transfer events in biological molecules. We show here that the high sensitivity of low-energy electrons to local electric fields can be employed to directly visualize individual charged adsorbates and to study their behavior in a quantitative way. This makes electron holography a unique probing tool for directly visualizing charge distributions with a sensitivity of a fraction of an elementary charge. Moreover, spatial resolution in the nanometer range and fast data acquisition inherent to lens-less low-energy electron holography allows for direct visual inspection of charge transfer processes.

  8. Direct correlation of observed phonon anomalies and maxima in the generalized susceptibilities of transition metal carbides

    International Nuclear Information System (INIS)

    Gupta, M.J.; Freeman, A.B.

    1976-01-01

    The generalized susceptibility, chi(q), of both NbC and TaC determined from APW energy band calculations show large maxima to occur at precisely those q/sub max/ values at which soft phonon modes were observed by Smith. Maxima in chi(q) are predicted for other directions. The locus of these q/sub max/ values can be represented by a warped cube of dimension approximately 1.2(2π/a) in momentum space--in striking agreement with the soft mode surface proposed phenomenologically by Weber. In sharp contrast, the chi(q) calculated for both ZrC and HfC--for which no phonon anomalies have been observed--fall off in all symmetry directions away from the zone center. The phonon anomalies in the transition metal carbides are thus interpreted as due to an ''overscreening'' effect resulting from an anomalous increase of the response function of the conduction electrons

  9. Development of direct observation aparatus of coal carbonization process by x-ray computerized tomography method

    International Nuclear Information System (INIS)

    Sakawa, Mitsuhiro; Shiraishi, Katsuhiko; Sakurai, Yoshihisa; Shimomura, Yasuto

    1987-01-01

    Coke production by chamber ovens has a long history and efforts are being continued to make the manufacturing process efficient and to preserve the environment. In this production by this method, however, it is hardly possible to obtain direct information during coal carbonization. Since the elements that compose coal and coke are carbon, hydrogen, oxygen, etc. and are similar to those of the human body, authors has developed a coke oven that permits the direct observation of the coal carbonization process using a soft X-ray computerized tomography (CT) apparatus used in medical treatment. The following phenomena can be observed as images by the coke oven for the CT method : 1) Changes in the bulk density of charge coal (including the difference in the water content), 2) Width of the plastic layer and movement of the plastic layer in the coke oven chamber, 3) Expansion and shrinkage of the charge in the coke oven chamber, 4) Initiation and growth of cracks. (author)

  10. Direct observation of asperity deformation of specimens with random rough surfaces in upsetting and indentation processes

    DEFF Research Database (Denmark)

    Azushima, A.; Kuba, S.; Tani, S.

    2006-01-01

    The trapping behavior of liquid lubricant and contact behavior of asperities at the workpiece-tool interface during upsetting and indentation are observed directly using a compression subpress which consists of a transparent die made of sapphire, a microscope with a CCD camera and a video system....... The experiments are carried out without lubricant and with lubricant. Specimens used are commercially pure A1100 aluminum with a random rough surface. From these observations, the change in the fraction of real contact area is measured by an image processor. The real contact area ratios in upsetting experiments...

  11. Direct Observation of Asperity Deformation of Specimen with Random Rough Surface in Upsetting Process

    DEFF Research Database (Denmark)

    Azushima, A.; Kuba, S.; Tani, S.

    2004-01-01

    The trapping behavior of liquid lubricant and contact behavior of asperities at the workpiece-tool interface during upsetting and indentation are observed directly using a compression subpress which consists of a transparent die made of sapphire, a microscope with a CCD camera and a video system....... The experiments are carried out without lubricant and with lubricant. Specimens used are commercially pure A1100 Aluminum with a random rough surface. From this observation, the change in the fraction of real contact area is measured by an image processor. The real contact area ratios in upsetting experiment...

  12. Virtual study groups and online Observed Structured Clinical Examinations practices - enabling trainees to enable themselves.

    Science.gov (United States)

    Davidson, Dennisa; Evans, Lois

    2018-03-01

    To explore online study groups as augmentation tools in preparing for the Royal Australian and New Zealand College of Psychiatrists Observed Structured Clinical Examinations (OSCE) for fellowship. An online survey of New Zealand trainees was carried out to assess exam preparedness and openness to virtual study groups and results analysed. Relevant material around virtual study groups for fellowship examinations was reviewed and used to inform a pilot virtual study group. Four New Zealand trainees took part in the pilot project, looking at using a virtual platform to augment OSCE preparation. Of the 50 respondents 36% felt adequately prepared for the OSCE. Sixty-four per cent were interested in using a virtual platform to augment their study. Virtual study groups were noted to be especially important for rural trainees, none of whom felt able to form study groups for themselves. The pilot virtual study group was trialled successfully. All four trainees reported the experience as subjectively beneficial to their examination preparation. Virtual platforms hold promise as an augmentation strategy for exam preparation, especially for rural trainees who are more geographically isolated and less likely to have peers preparing for the same examinations.

  13. Direct Atomic Force Microscopy Observation of DNA Tile Crystal Growth at the Single-Molecule Level

    OpenAIRE

    Evans, Constantine G.; Hariadi, Rizal F.; Winfree, Erik

    2012-01-01

    While the theoretical implications of models of DNA tile self-assembly have been extensively researched and such models have been used to design DNA tile systems for use in experiments, there has been little research testing the fundamental assumptions of those models. In this paper, we use direct observation of individual tile attachments and detachments of two DNA tile systems on a mica surface imaged with an atomic force microscope (AFM) to compile statistics of tile attachments and detach...

  14. Recent observations of distant matter - Direct clues to birth and evolution

    International Nuclear Information System (INIS)

    Koo, D.C.

    1988-01-01

    Highlights of recent deep observations of field galaxies, clusters of galaxies, radio galaxies, quasar absorption lines, and quasars are used to illustrate our progress since the 1981 Vatican Conference on Astrophysical Cosmology and to review the current status of evidence for evolution in their intrinsic properties and large-scale clustering. The birth and ages of galaxies can be explored directly by exploiting these classes of objects to search for primeval galaxies. 96 refs

  15. Abstract structure of partial function $*$-algebras over semi-direct product of locally compact groups

    Directory of Open Access Journals (Sweden)

    Arash Ghaani Farashahi

    2015-12-01

    Full Text Available This article presents a unified approach to the abstract notions of partial convolution and involution in $L^p$-function spaces over semi-direct product of locally compact groups. Let $H$ and $K$ be locally compact groups and $tau:Hto Aut(K$ be a continuous homomorphism.  Let $G_tau=Hltimes_tau K$ be the semi-direct product of $H$ and $K$ with respect to $tau$. We define left and right $tau$-convolution on $L^1(G_tau$ and we show that, with respect to each of them, the function space $L^1(G_tau$ is a Banach algebra. We define $tau$-convolution as a linear combination of the left and right $tau$-convolution and we show that the $tau$-convolution is commutative if and only if $K$ is abelian. We prove that there is a $tau$-involution on $L^1(G_tau$ such that with respect to the $tau$-involution and $tau$-convolution, $L^1(G_tau$ is a non-associative Banach $*$-algebra. It is also shown that when $K$ is abelian, the $tau$-involution and $tau$-convolution make $L^1(G_tau$ into a Jordan Banach $*$-algebra. Finally, we also present the generalized notation of $tau$-convolution for other $L^p$-spaces with $p>1$.

  16. State-of-the-art multi-wavelength observations of nearby brightest group/cluster galaxies

    Science.gov (United States)

    Gendron-Marsolais, Marie-Lou; Hlavacek-Larrondo, Julie

    2018-01-01

    Nearby galaxy groups and clusters are crucial to our understanding of the impact of nuclear outbursts on the intracluster medium as their proximity allows us to study in detail the processes of feedback from active galactic nuclei in these systems. In this talk, I will present state-of-the-art multi-wavelength observations signatures of this mechanism.I will first show results on multi-configuration 230-470 MHz observations of the Perseus cluster from the Karl G. Jansky Very Large Array, probing the non-thermal emission from the old particle population of the AGN outflows. These observations reveal a multitude of new structures associated with the “mini-halo” and illustrate the high-quality images that can be obtained with the new JVLA at low radio-frequencies.Second, I will present new observations with the optical imaging Fourier transform spectrometer SITELLE (CFHT) of NGC 1275, the Perseus cluster's brightest galaxy. With its wide field of view, it is the only integral field unit spectroscopy instrument able to cover the large emission-line filamentary nebula in NGC 1275. I will present the first detailed velocity map of this nebula in its entirety and tackle the question of its origin (residual cooling flow or dragged gas).Finally, I will present deep Chandra observations of the nearby early-type massive elliptical galaxy NGC 4472, the most optically luminous galaxy in the local Universe, lying on the outskirts of the Virgo cluster. Enhanced X-ray rims around the radio lobes are detected and interpreted as gas uplifted from the core by the buoyant rise of the radio bubbles. We estimate the energy required to lift the gas to constitute a significant fraction of the total outburst energy.I will thus show how these high-fidelity observations of nearby brightest group/cluster galaxies are improving our understanding of the AGN feedback mechanism taking place in galaxy groups and clusters.

  17. Participant observation of time allocation, direct patient contact and simultaneous activities in hospital physicians

    Directory of Open Access Journals (Sweden)

    Zupanc Andrea

    2009-06-01

    Full Text Available Abstract Background Hospital physicians' time is a critical resource in medical care. Two aspects are of interest. First, the time spent in direct patient contact – a key principle of effective medical care. Second, simultaneous task performance ('multitasking' which may contribute to medical error, impaired safety behaviour, and stress. There is a call for instruments to assess these aspects. A preliminary study to gain insight into activity patterns, time allocation and simultaneous activities of hospital physicians was carried out. Therefore an observation instrument for time-motion-studies in hospital settings was developed and tested. Methods 35 participant observations of internists and surgeons of a German municipal 300-bed hospital were conducted. Complete day shifts of hospital physicians on wards, emergency ward, intensive care unit, and operating room were continuously observed. Assessed variables of interest were time allocation, share of direct patient contact, and simultaneous activities. Inter-rater agreement of Kappa = .71 points to good reliability of the instrument. Results Hospital physicians spent 25.5% of their time at work in direct contact with patients. Most time was allocated to documentation and conversation with colleagues and nursing staff. Physicians performed parallel simultaneous activities for 17–20% of their work time. Communication with patients, documentation, and conversation with colleagues and nursing staff were the most frequently observed simultaneous activities. Applying logit-linear analyses, specific primary activities increase the probability of particular simultaneous activities. Conclusion Patient-related working time in hospitals is limited. The potential detrimental effects of frequently observed simultaneous activities on performance outcomes need further consideration.

  18. Neural dynamics of motion perception: direction fields, apertures, and resonant grouping.

    Science.gov (United States)

    Grossberg, S; Mingolla, E

    1993-03-01

    A neural network model of global motion segmentation by visual cortex is described. Called the motion boundary contour system (BCS), the model clarifies how ambiguous local movements on a complex moving shape are actively reorganized into a coherent global motion signal. Unlike many previous researchers, we analyze how a coherent motion signal is imparted to all regions of a moving figure, not only to regions at which unambiguous motion signals exist. The model hereby suggests a solution to the global aperture problem. The motion BCS describes how preprocessing of motion signals by a motion oriented contrast (MOC) filter is joined to long-range cooperative grouping mechanisms in a motion cooperative-competitive (MOCC) loop to control phenomena such as motion capture. The motion BCS is computed in parallel with the static BCS of Grossberg and Mingolla (1985a, 1985b, 1987). Homologous properties of the motion BCS and the static BCS, specialized to process motion directions and static orientations, respectively, support a unified explanation of many data about static form perception and motion form perception that have heretofore been unexplained or treated separately. Predictions about microscopic computational differences of the parallel cortical streams V1-->MT and V1-->V2-->MT are made--notably, the magnocellular thick stripe and parvocellular interstripe streams. It is shown how the motion BCS can compute motion directions that may be synthesized from multiple orientations with opposite directions of contrast. Interactions of model simple cells, complex cells, hyper-complex cells, and bipole cells are described, with special emphasis given to new functional roles in direction disambiguation for endstopping at multiple processing stages and to the dynamic interplay of spatially short-range and long-range interactions.

  19. Rhodium-catalysed syn-carboamination of alkenes via a transient directing group.

    Science.gov (United States)

    Piou, Tiffany; Rovis, Tomislav

    2015-11-05

    Alkenes are the most ubiquitous prochiral functional groups--those that can be converted from achiral to chiral in a single step--that are accessible to synthetic chemists. For this reason, difunctionalization reactions of alkenes (whereby two functional groups are added to the same double bond) are particularly important, as they can be used to produce highly complex molecular architectures. Stereoselective oxidation reactions, including dihydroxylation, aminohydroxylation and halogenation, are well established methods for functionalizing alkenes. However, the intermolecular incorporation of both carbon- and nitrogen-based functionalities stereoselectively across an alkene has not been reported. Here we describe the rhodium-catalysed carboamination of alkenes at the same (syn) face of a double bond, initiated by a carbon-hydrogen activation event that uses enoxyphthalimides as the source of both the carbon and the nitrogen functionalities. The reaction methodology allows for the intermolecular, stereospecific formation of one carbon-carbon and one carbon-nitrogen bond across an alkene, which is, to our knowledge, unprecedented. The reaction design involves the in situ generation of a bidentate directing group and the use of a new cyclopentadienyl ligand to control the reactivity of rhodium. The results provide a new way of synthesizing functionalized alkenes, and should lead to the convergent and stereoselective assembly of amine-containing acyclic molecules.

  20. Feedback in formative OSCEs: comparison between direct observation and video-based formats

    Science.gov (United States)

    Junod Perron, Noëlle; Louis-Simonet, Martine; Cerutti, Bernard; Pfarrwaller, Eva; Sommer, Johanna; Nendaz, Mathieu

    2016-01-01

    Introduction Medical students at the Faculty of Medicine, University of Geneva, Switzerland, have the opportunity to practice clinical skills with simulated patients during formative sessions in preparation for clerkships. These sessions are given in two formats: 1) direct observation of an encounter followed by verbal feedback (direct feedback) and 2) subsequent review of the videotaped encounter by both student and supervisor (video-based feedback). The aim of the study was to evaluate whether content and process of feedback differed between both formats. Methods In 2013, all second- and third-year medical students and clinical supervisors involved in formative sessions were asked to take part in the study. A sample of audiotaped feedback sessions involving supervisors who gave feedback in both formats were analyzed (content and process of the feedback) using a 21-item feedback scale. Results Forty-eight audiotaped feedback sessions involving 12 supervisors were analyzed (2 direct and 2 video-based sessions per supervisor). When adjusted for the length of feedback, there were significant differences in terms of content and process between both formats; the number of communication skills and clinical reasoning items addressed were higher in the video-based format (11.29 vs. 7.71, p=0.002 and 3.71 vs. 2.04, p=0.010, respectively). Supervisors engaged students more actively during the video-based sessions than during direct feedback sessions (self-assessment: 4.00 vs. 3.17, p=0.007; active problem-solving: 3.92 vs. 3.42, p=0.009). Students made similar observations and tended to consider that the video feedback was more useful for improving some clinical skills. Conclusion Video-based feedback facilitates discussion of clinical reasoning, communication, and professionalism issues while at the same time actively engaging students. Different time and conceptual frameworks may explain observed differences. The choice of feedback format should depend on the educational

  1. Feedback in formative OSCEs: comparison between direct observation and video-based formats

    Directory of Open Access Journals (Sweden)

    Noëlle Junod Perron

    2016-11-01

    Full Text Available Introduction: Medical students at the Faculty of Medicine, University of Geneva, Switzerland, have the opportunity to practice clinical skills with simulated patients during formative sessions in preparation for clerkships. These sessions are given in two formats: 1 direct observation of an encounter followed by verbal feedback (direct feedback and 2 subsequent review of the videotaped encounter by both student and supervisor (video-based feedback. The aim of the study was to evaluate whether content and process of feedback differed between both formats. Methods: In 2013, all second- and third-year medical students and clinical supervisors involved in formative sessions were asked to take part in the study. A sample of audiotaped feedback sessions involving supervisors who gave feedback in both formats were analyzed (content and process of the feedback using a 21-item feedback scale. Results: Forty-eight audiotaped feedback sessions involving 12 supervisors were analyzed (2 direct and 2 video-based sessions per supervisor. When adjusted for the length of feedback, there were significant differences in terms of content and process between both formats; the number of communication skills and clinical reasoning items addressed were higher in the video-based format (11.29 vs. 7.71, p=0.002 and 3.71 vs. 2.04, p=0.010, respectively. Supervisors engaged students more actively during the video-based sessions than during direct feedback sessions (self-assessment: 4.00 vs. 3.17, p=0.007; active problem-solving: 3.92 vs. 3.42, p=0.009. Students made similar observations and tended to consider that the video feedback was more useful for improving some clinical skills. Conclusion: Video-based feedback facilitates discussion of clinical reasoning, communication, and professionalism issues while at the same time actively engaging students. Different time and conceptual frameworks may explain observed differences. The choice of feedback format should depend on

  2. Direct Observation of Heavy-Tailed Storage Times of Bed Load Tracer Particles Causing Anomalous Superdiffusion

    Science.gov (United States)

    Bradley, D. Nathan

    2017-12-01

    A consensus has formed that the step length distribution of fluvial bed load is thin tailed and that the observed anomalous superdiffusion of bed load tracer particles must arise from heavy-tailed resting times. However, heavy-tailed resting times have never been directly observed in the field over multiple floods. Using 9 years of data from a large bed load tracer experiment, I show that the spatial variance of the tracer plume scales faster than linearly with integrated excess stream power, indicating anomalous superdiffusion. The superdiffusion is caused by a heavy-tailed distribution of observed storage times that is fit with a truncated Pareto distribution with a tail parameter that is predicted by anomalous diffusion theory. The heavy-tailed distribution of storage times causes the tracer virtual velocity to slow over time, indicated by a sublinear increase in the mean displacement that is predicted by the storage time distribution tail parameter.

  3. Direct observation of the orbital spin Kondo effect in gallium arsenide quantum dots

    Science.gov (United States)

    Shang, Ru-Nan; Zhang, Ting; Cao, Gang; Li, Hai-Ou; Xiao, Ming; Guo, Guang-Can; Guo, Guo-Ping

    2018-02-01

    Besides the spin Kondo effect, other degrees of freedom can give rise to the pseudospin Kondo effect. We report a direct observation of the orbital spin Kondo effect in a series-coupled gallium arsenide (GaAs) double quantum dot device where orbital degrees act as pseudospin. Electron occupation in both dots induces a pseudospin Kondo effect. In a region of one net spin impurity, complete spectra with three resonance peaks are observed. Furthermore, we observe a pseudo-Zeeman effect and demonstrate its electrical controllability for the artificial pseudospin in this orbital spin Kondo process via gate voltage control. The fourfold degeneracy point is realized at a specific value supplemented by spin degeneracy, indicating a transition from the SU(2) to the SU(4) Kondo effect.

  4. Direct Observation of Domain-Wall Surface Tension by Deflating or Inflating a Magnetic Bubble

    Science.gov (United States)

    Zhang, Xueying; Vernier, Nicolas; Zhao, Weisheng; Yu, Haiming; Vila, Laurent; Zhang, Yue; Ravelosona, Dafiné

    2018-02-01

    The surface energy of a magnetic domain wall (DW) strongly affects its static and dynamic behaviors. However, this effect is seldom directly observed, and some of the related phenomena are not well understood. Moreover, a reliable method to quantify the DW surface energy is still absent. Here, we report a series of experiments in which the DW surface energy becomes a dominant parameter. We observe that a semicircular magnetic domain bubble can spontaneously collapse under the Laplace pressure induced by DW surface energy. We further demonstrate that the surface energy can lead to a geometrically induced pinning when the DW propagates in a Hall cross or from a nanowire into a nucleation pad. Based on these observations, we develop two methods to quantify the DW surface energy, which can be very helpful in the estimation of intrinsic parameters such as Dzyaloshinskii-Moriya interactions or exchange stiffness in magnetic ultrathin films.

  5. Blue Whale (Balaenoptera musculus Behavior and Group Dynamics as Observed from an Aircraft off Southern California

    Directory of Open Access Journals (Sweden)

    Kate Lomac-MacNair

    2016-02-01

    Full Text Available Group behavior and interactions of endangered blue whales (Balaenoptera musculus have not been systematically studied. Such behavioral data are often overlooked when assessing anthropogenic effects. Yet behavioral data are necessary to compare “normal” behaviors with behavior affected by anthropogenic factors of concern relative to effective management and recovery of blue whales. For a baseline study, we hypothesized that the response variables sighting rate, group size, calf presence and group cohesion (i.e., spacing between individuals within a group differed according to the spatio-temporal explanatory variables behavioral state, time of day, season, water depth and distance from shore. To address our hypotheses, we flew systematic line transect surveys in southern California and collected focal group data. Two sets of data were separately analyzed using different sampling approaches: (1 point sample data associated with the first sighting of a blue whale(s, and (2 extended all-occurrence focal group behavioral sampling data (i.e., focal follows collected on a subsample of all sightings while the aircraft circled at a radial distance of approximately 0.5-1 km and an altitude of 1,500 m for extended periods of 5 – 60 minutes. Chi-square contingency table and G² analyses were used to assess statistical relationships between response and explanatory variables. We conducted 18 one-week-long aerial surveys spanning October 2008 through May 2013 (at least once during every month except December, totaling 87,555 km of observation effort. Seventy blue whale sightings (117 individuals were seen, ranging in size from 1 – 6 whales, and focal follow was performed on over half (55% of these sightings. Results supported our hypotheses that blue whale group characteristics were related to behavioral state and spatio-temporal variables. Sighting rates were significantly highest during summer followed by spring, fall, and winter. Group type differed

  6. The FluxCompensator: Making Radiative Transfer Models of Hydrodynamical Simulations Directly Comparable to Real Observations

    Energy Technology Data Exchange (ETDEWEB)

    Koepferl, Christine M.; Robitaille, Thomas P., E-mail: koepferl@usm.lmu.de [Max Planck Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany)

    2017-11-01

    When modeling astronomical objects throughout the universe, it is important to correctly treat the limitations of the data, for instance finite resolution and sensitivity. In order to simulate these effects, and to make radiative transfer models directly comparable to real observations, we have developed an open-source Python package called the FluxCompensator that enables the post-processing of the output of 3D Monte Carlo radiative transfer codes, such as Hyperion. With the FluxCompensator, realistic synthetic observations can be generated by modeling the effects of convolution with arbitrary point-spread functions, transmission curves, finite pixel resolution, noise, and reddening. Pipelines can be applied to compute synthetic observations that simulate observatories, such as the Spitzer Space Telescope or the Herschel Space Observatory . Additionally, this tool can read in existing observations (e.g., FITS format) and use the same settings for the synthetic observations. In this paper, we describe the package as well as present examples of such synthetic observations.

  7. The FluxCompensator: Making Radiative Transfer Models of Hydrodynamical Simulations Directly Comparable to Real Observations

    Science.gov (United States)

    Koepferl, Christine M.; Robitaille, Thomas P.

    2017-11-01

    When modeling astronomical objects throughout the universe, it is important to correctly treat the limitations of the data, for instance finite resolution and sensitivity. In order to simulate these effects, and to make radiative transfer models directly comparable to real observations, we have developed an open-source Python package called the FluxCompensator that enables the post-processing of the output of 3D Monte Carlo radiative transfer codes, such as Hyperion. With the FluxCompensator, realistic synthetic observations can be generated by modeling the effects of convolution with arbitrary point-spread functions, transmission curves, finite pixel resolution, noise, and reddening. Pipelines can be applied to compute synthetic observations that simulate observatories, such as the Spitzer Space Telescope or the Herschel Space Observatory. Additionally, this tool can read in existing observations (e.g., FITS format) and use the same settings for the synthetic observations. In this paper, we describe the package as well as present examples of such synthetic observations.

  8. Midwives' experiences of performing maternal observations and escalating concerns: a focus group study.

    Science.gov (United States)

    Jeffery, Justine; Hewison, Alistair; Goodwin, Laura; Kenyon, Sara

    2017-09-02

    For the past decade, Maternal Mortality Reports, published in the United Kingdom every three years, have consistently raised concerns about maternal observations in maternity care. The reports identify that observations are not being done, not being completed fully, are not recorded on Early Warning Score systems, and/or are not escalated appropriately. This has resulted in delays in referral, intervention and increases the risk of maternal morbidity or mortality. However there has been little exploration of the possible reasons for non-completion of maternal observations. The aim of this study was to explore midwives' experiences of performing maternal observations and escalating concerns in rural and urban maternity settings in the West Midlands of England. A qualitative design involving a series of six focus groups with midwives and Supervisors of Midwives was employed to investigate the facilitators of, and barriers to the completion of maternal observations. Eighteen Midwives and 8 Supervisors of Midwives participated in a total of 6 focus groups. Three key themes emerged from the data: (1) Organisation of Maternal Observations (including delegation of tasks to Midwifery Support Workers, variation in their training, the care model used e.g. one to one care, and staffing issues); (2) Prioritisation of Maternal Observations (including the role of professional judgement and concerns expressed by midwives that they did not feel equipped to care for women with complex clinical needs; and (3) Negotiated Escalation (including the inappropriate response from senior staff to use of Modified Early Warning Score systems, and the emotional impact of escalation). A number of organisational and cultural barriers exist to the completion of maternal observations and the escalation of concerns. In order to address these the following actions are recommended: standardised training for Midwifery Support Workers, review of training of midwives to ensure it addresses the

  9. An accuracy measurement method for star trackers based on direct astronomic observation.

    Science.gov (United States)

    Sun, Ting; Xing, Fei; Wang, Xiaochu; You, Zheng; Chu, Daping

    2016-03-07

    Star tracker is one of the most promising optical attitude measurement devices and it is widely used in spacecraft for its high accuracy. However, how to realize and verify such an accuracy remains a crucial but unsolved issue until now. The authenticity of the accuracy measurement method of a star tracker will eventually determine the satellite performance. A new and robust accuracy measurement method for a star tracker based on the direct astronomical observation is proposed here. In comparison with the conventional method with simulated stars, this method utilizes real navigation stars as observation targets which makes the measurement results more authoritative and authentic. Transformations between different coordinate systems are conducted on the account of the precision movements of the Earth, and the error curves of directional vectors are obtained along the three axes. Based on error analysis and accuracy definitions, a three-axis accuracy evaluation criterion has been proposed in this paper, which could determine pointing and rolling accuracy of a star tracker directly. Experimental measurements confirm that this method is effective and convenient to implement. Such a measurement environment is close to the in-orbit conditions and it can satisfy the stringent requirement for high-accuracy star trackers.

  10. Associations of group level popularity with observed behavior and influence in a dyadic context.

    Science.gov (United States)

    Lansu, Tessa A M; Cillessen, Antonius H N

    2015-12-01

    This study examined the association between popularity in the peer group and adolescents' behavior in a dyadic context. After collecting peer nominations for popularity, 218 early adolescents (M(age) = 11.0 years) in 109 randomly composed same-sex dyads participated in a discussion task where they planned a party for their classroom. From digital recordings of the sessions, each participant's influence, involvement, skillful leadership, coercive resource control, submissiveness, positivity, and negativity were observed. Analyses with the actor-partner interdependence model (APIM) demonstrated that for girls high group level popularity was associated with a socially sensitive interaction style and influence in the dyadic context. For both boys and girls, the interaction partner's group level popularity negatively predicted their use of coercive resource control strategies and negative behavior in the dyad. For girls, in addition, the interaction partner's group level popularity also positively predicted their submissiveness and negatively predicted their task influence. These results indicate that, in particular for girls, adolescents' group level popularity plays an important role in the behavior of both peers in a cooperative dyadic context. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Direct alcohol fuel cells: Increasing platinum performance by modification with sp-group metals

    Science.gov (United States)

    Figueiredo, Marta C.; Sorsa, Olli; Doan, Nguyet; Pohjalainen, Elina; Hildebrand, Helga; Schmuki, Patrik; Wilson, Benjamin P.; Kallio, Tanja

    2015-02-01

    By using sp group metals as modifiers, the catalytic properties of Pt can be improved toward alcohols oxidation. In this work we report the performance increase of direct alcohol fuel cells (DAFC) fuelled with ethanol or 2-propanol with platinum based anode electrodes modified with Bi and Sb adatoms. For example, by simply adding Sb to the Pt/C based anode ink during membrane electrode assembly fabrication of a direct ethanol fuel cell (DEFC) its performance is improved three-fold, with more than 100 mV increase in the open circuit potential. For the fuel cell fuelled with 2-propanol high power densities are obtained at very high potentials with these catalyst materials suggesting a great improvement for practical applications. Particularly in the case of Pt/C-Bi, the improvement is such that within 0.6 V (from 0.7 to 0.1 V) the power densities are between 7 and 9 mW/cm2. The results obtained with these catalysts are in the same range as those obtained with other bimetallic catalysts comprising of PtRu and PtSn, which are currently considered to be the best for these type of fuel cells and that are obtained by more complicated (and consequently more expensive) methods.

  12. Tracking individual membrane proteins and their biochemistry: The power of direct observation.

    Science.gov (United States)

    Barden, Adam O; Goler, Adam S; Humphreys, Sara C; Tabatabaei, Samaneh; Lochner, Martin; Ruepp, Marc-David; Jack, Thomas; Simonin, Jonathan; Thompson, Andrew J; Jones, Jeffrey P; Brozik, James A

    2015-11-01

    The advent of single molecule fluorescence microscopy has allowed experimental molecular biophysics and biochemistry to transcend traditional ensemble measurements, where the behavior of individual proteins could not be precisely sampled. The recent explosion in popularity of new super-resolution and super-localization techniques coupled with technical advances in optical designs and fast highly sensitive cameras with single photon sensitivity and millisecond time resolution have made it possible to track key motions, reactions, and interactions of individual proteins with high temporal resolution and spatial resolution well beyond the diffraction limit. Within the purview of membrane proteins and ligand gated ion channels (LGICs), these outstanding advances in single molecule microscopy allow for the direct observation of discrete biochemical states and their fluctuation dynamics. Such observations are fundamentally important for understanding molecular-level mechanisms governing these systems. Examples reviewed here include the effects of allostery on the stoichiometry of ligand binding in the presence of fluorescent ligands; the observation of subdomain partitioning of membrane proteins due to microenvironment effects; and the use of single particle tracking experiments to elucidate characteristics of membrane protein diffusion and the direct measurement of thermodynamic properties, which govern the free energy landscape of protein dimerization. The review of such characteristic topics represents a snapshot of efforts to push the boundaries of fluorescence microscopy of membrane proteins to the absolute limit. This article is part of the Special Issue entitled 'Fluorescent Tools in Neuropharmacology'. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Photoacoustics of single laser-trapped nanodroplets for the direct observation of nanofocusing in aerosol photokinetics

    Science.gov (United States)

    Cremer, Johannes W.; Thaler, Klemens M.; Haisch, Christoph; Signorell, Ruth

    2016-03-01

    Photochemistry taking place in atmospheric aerosol droplets has a significant impact on the Earth's climate. Nanofocusing of electromagnetic radiation inside aerosols plays a crucial role in their absorption behaviour, since the radiation flux inside the droplet strongly affects the activation rate of photochemically active species. However, size-dependent nanofocusing effects in the photokinetics of small aerosols have escaped direct observation due to the inability to measure absorption signatures from single droplets. Here we show that photoacoustic measurements on optically trapped single nanodroplets provide a direct, broadly applicable method to measure absorption with attolitre sensitivity. We demonstrate for a model aerosol that the photolysis is accelerated by an order of magnitude in the sub-micron to micron size range, compared with larger droplets. The versatility of our technique promises broad applicability to absorption studies of aerosol particles, such as atmospheric aerosols where quantitative photokinetic data are critical for climate predictions.

  14. First Direct Observation of Runaway-Electron-Driven Whistler Waves in Tokamaks

    Science.gov (United States)

    Spong, D. A.; Heidbrink, W. W.; Paz-Soldan, C.; Du, X. D.; Thome, K. E.; Van Zeeland, M. A.; Collins, C.; Lvovskiy, A.; Moyer, R. A.; Austin, M. E.; Brennan, D. P.; Liu, C.; Jaeger, E. F.; Lau, C.

    2018-04-01

    DIII-D experiments at low density (ne˜1019 m-3 ) have directly measured whistler waves in the 100-200 MHz range excited by multi-MeV runaway electrons. Whistler activity is correlated with runaway intensity (hard x-ray emission level), occurs in novel discrete frequency bands, and exhibits nonlinear limit-cycle-like behavior. The measured frequencies scale with the magnetic field strength and electron density as expected from the whistler dispersion relation. The modes are stabilized with increasing magnetic field, which is consistent with wave-particle resonance mechanisms. The mode amplitudes show intermittent time variations correlated with changes in the electron cyclotron emission that follow predator-prey cycles. These can be interpreted as wave-induced pitch angle scattering of moderate energy runaways. The tokamak runaway-whistler mechanisms have parallels to whistler phenomena in ionospheric plasmas. The observations also open new directions for the modeling and active control of runaway electrons in tokamaks.

  15. FUZZY LOGIC BASED ADAPTATION MECHANISM FOR ADAPTIVE LUENBERGER OBSERVER SENSORLESS DIRECT TORQUE CONTROL OF INDUCTION MOTOR

    Directory of Open Access Journals (Sweden)

    A. BENNASSAR

    2016-01-01

    Full Text Available Many industrial applications require high performance speed sensorless operation and demand new control methods in order to obtain fast dynamic response and insensitive to external disturbances. The current research aims to present the performance of the sensorless direct torque control (DTC of an induction motor (IM using adaptive Luenberger observer (ALO with fuzzy logic controller (FLC for adaptation mechanism. The rotor speed is regulated by proportional integral (PI anti-windup controller. The proposed strategy is directed to reduce the ripple on the torque and the flux. Numerical simulation results show the good performance and effectiveness of the proposed sensorless control for different references of the speed even both low and high speeds.

  16. Direct observation of multistep energy transfer in LHCII with fifth-order 3D electronic spectroscopy.

    Science.gov (United States)

    Zhang, Zhengyang; Lambrev, Petar H; Wells, Kym L; Garab, Győző; Tan, Howe-Siang

    2015-07-31

    During photosynthesis, sunlight is efficiently captured by light-harvesting complexes, and the excitation energy is then funneled towards the reaction centre. These photosynthetic excitation energy transfer (EET) pathways are complex and proceed in a multistep fashion. Ultrafast two-dimensional electronic spectroscopy (2DES) is an important tool to study EET processes in photosynthetic complexes. However, the multistep EET processes can only be indirectly inferred by correlating different cross peaks from a series of 2DES spectra. Here we directly observe multistep EET processes in LHCII using ultrafast fifth-order three-dimensional electronic spectroscopy (3DES). We measure cross peaks in 3DES spectra of LHCII that directly indicate energy transfer from excitons in the chlorophyll b (Chl b) manifold to the low-energy level chlorophyll a (Chl a) via mid-level Chl a energy states. This new spectroscopic technique allows scientists to move a step towards mapping the complete complex EET processes in photosynthetic systems.

  17. Comparison of small-group training with self-directed internet-based training in inhaler techniques.

    Science.gov (United States)

    Toumas, Mariam; Basheti, Iman A; Bosnic-Anticevich, Sinthia Z

    2009-08-28

    To compare the effectiveness of small-group training in correct inhaler technique with self-directed Internet-based training. Pharmacy students were randomly allocated to 1 of 2 groups: small-group training (n = 123) or self-directed Internet-based training (n = 113). Prior to intervention delivery, all participants were given a placebo Turbuhaler and product information leaflet and received inhaler technique training based on their group. Technique was assessed following training and predictors of correct inhaler technique were examined. There was a significant improvement in the number of participants demonstrating correct technique in both groups (small group training, 12% to 63%; p training, 9% to 59%; p groups in the percent change (n = 234, p > 0.05). Increased student confidence following the intervention was a predictor for correct inhaler technique. Self-directed Internet-based training is as effective as small-group training in improving students' inhaler technique.

  18. Airborne hyperspectral observations of surface and cloud directional reflectivity using a commercial digital camera

    Directory of Open Access Journals (Sweden)

    A. Ehrlich

    2012-04-01

    Full Text Available Spectral radiance measurements by a digital single-lens reflex camera were used to derive the directional reflectivity of clouds and different surfaces in the Arctic. The camera has been calibrated radiometrically and spectrally to provide accurate radiance measurements with high angular resolution. A comparison with spectral radiance measurements with the Spectral Modular Airborne Radiation measurement sysTem (SMART-Albedometer showed an agreement within the uncertainties of both instruments (6% for both. The directional reflectivity in terms of the hemispherical directional reflectance factor (HDRF was obtained for sea ice, ice-free ocean and clouds. The sea ice, with an albedo of ρ = 0.96 (at 530 nm wavelength, showed an almost isotropic HDRF, while sun glint was observed for the ocean HDRF (ρ = 0.12. For the cloud observations with ρ = 0.62, the cloudbow – a backscatter feature typically for scattering by liquid water droplets – was covered by the camera. For measurements above heterogeneous stratocumulus clouds, the required number of images to obtain a mean HDRF that clearly exhibits the cloudbow has been estimated at about 50 images (10 min flight time. A representation of the HDRF as a function of the scattering angle only reduces the image number to about 10 (2 min flight time.

    The measured cloud and ocean HDRF have been compared to radiative transfer simulations. The ocean HDRF simulated with the observed surface wind speed of 9 m s−1 agreed best with the measurements. For the cloud HDRF, the best agreement was obtained by a broad and weak cloudbow simulated with a cloud droplet effective radius of Reff = 4 μm. This value agrees with the particle sizes derived from in situ measurements and retrieved from the spectral radiance of the SMART-Albedometer.

  19. Constraining supersymmetric models using Higgs physics, precision observables and direct searches

    International Nuclear Information System (INIS)

    Zeune, Lisa

    2014-08-01

    We present various complementary possibilities to exploit experimental measurements in order to test and constrain supersymmetric (SUSY) models. Direct searches for SUSY particles have not resulted in any signal so far, and limits on the SUSY parameter space have been set. Measurements of the properties of the observed Higgs boson at ∝126 GeV as well as of the W boson mass (M W ) can provide valuable indirect constraints, supplementing the ones from direct searches. This thesis is divided into three major parts: In the first part we present the currently most precise prediction for M W in the Minimal Supersymmetric Standard Model (MSSM) with complex parameters and in the Next-to-Minimal Supersymmetric Standard Model (NMSSM). The evaluation includes the full one-loop result and all relevant available higher order corrections of Standard Model (SM) and SUSY type. We perform a detailed scan over the MSSM parameter space, taking into account the latest experimental results, including the observation of a Higgs signal. We find that the current measurements for M W and the top quark mass (m t ) slightly favour a non-zero SUSY contribution. The impact of different SUSY sectors on the prediction of M W as well as the size of the higher-order SUSY corrections are analysed both in the MSSM and the NMSSM. We investigate the genuine NMSSM contribution from the extended Higgs and neutralino sectors and highlight differences between the M W predictions in the two SUSY models. In the second part of the thesis we discuss possible interpretations of the observed Higgs signal in SUSY models. The properties of the observed Higgs boson are compatible with the SM so far, but many other interpretations are also possible. Performing scans over the relevant parts of the MSSM and the NMSSM parameter spaces and applying relevant constraints from Higgs searches, flavour physics and electroweak measurements, we find that a Higgs boson at ∝126 GeV, which decays into two photons, can in

  20. Friction of elastomer-on-glass system and direct observation of its frictional interface

    International Nuclear Information System (INIS)

    Okamoto, Yoshihiro; Nishio, Kazuyuki; Sugiura, Jun-ichi; Hirano, Motohisa; Nitta, Takahiro

    2007-01-01

    We performed a study on the static friction of PDMS elastomers with well-defined surface topography sliding over glass. An experimental setup for simultaneous measurements of friction force and direct observations of frictional interface has been developed. The static friction force was nearly proportional to normal load. The static friction force was independent of stick time. The simultaneous measurements revealed that the static friction force was proportional to the total area of contact. The coefficient was nearly independent of the surface topography of PDMS elastomers

  1. Adjustable Parameter-Based Distributed Fault Estimation Observer Design for Multiagent Systems With Directed Graphs.

    Science.gov (United States)

    Zhang, Ke; Jiang, Bin; Shi, Peng

    2017-02-01

    In this paper, a novel adjustable parameter (AP)-based distributed fault estimation observer (DFEO) is proposed for multiagent systems (MASs) with the directed communication topology. First, a relative output estimation error is defined based on the communication topology of MASs. Then a DFEO with AP is constructed with the purpose of improving the accuracy of fault estimation. Based on H ∞ and H 2 with pole placement, multiconstrained design is given to calculate the gain of DFEO. Finally, simulation results are presented to illustrate the feasibility and effectiveness of the proposed DFEO design with AP.

  2. Validity, reliability, feasibility, acceptability and educational impact of direct observation of procedural skills (DOPS).

    Science.gov (United States)

    Naeem, Naghma

    2013-01-01

    Direct observation of procedural skills (DOPS) is a new workplace assessment tool. The aim of this narrative review of literature is to summarize the available evidence about the validity, reliability, feasibility, acceptability and educational impact of DOPS. A PubMed database and Google search of the literature on DOPS published from January 2000 to January 2012 was conducted which yielded 30 articles. Thirteen articles were selected for full text reading and review. In the reviewed literature, DOPS was found to be a useful tool for assessment of procedural skills, but further research is required to prove its utility as a workplace based assessment instrument.

  3. Direct observation of TALE protein dynamics reveals a two-state search mechanism.

    Science.gov (United States)

    Cuculis, Luke; Abil, Zhanar; Zhao, Huimin; Schroeder, Charles M

    2015-06-01

    Transcription activator-like effector (TALE) proteins are a class of programmable DNA-binding proteins for which the fundamental mechanisms governing the search process are not fully understood. Here we use single-molecule techniques to directly observe TALE search dynamics along DNA templates. We find that TALE proteins are capable of rapid diffusion along DNA using a combination of sliding and hopping behaviour, which suggests that the TALE search process is governed in part by facilitated diffusion. We also observe that TALE proteins exhibit two distinct modes of action during the search process-a search state and a recognition state-facilitated by different subdomains in monomeric TALE proteins. Using TALE truncation mutants, we further demonstrate that the N-terminal region of TALEs is required for the initial non-specific binding and subsequent rapid search along DNA, whereas the central repeat domain is required for transitioning into the site-specific recognition state.

  4. Interactions between C and Cu atoms in single-layer graphene: direct observation and modelling.

    Science.gov (United States)

    Kano, Emi; Hashimoto, Ayako; Kaneko, Tomoaki; Tajima, Nobuo; Ohno, Takahisa; Takeguchi, Masaki

    2016-01-07

    Metal doping into the graphene lattice has been studied recently to develop novel nanoelectronic devices and to gain an understanding of the catalytic activities of metals in nanocarbon structures. Here we report the direct observation of interactions between Cu atoms and single-layer graphene by transmission electron microscopy. We document stable configurations of Cu atoms in the graphene sheet and unique transformations of graphene promoted by Cu atoms. First-principles calculations based on density functional theory reveal a reduction of energy barrier that caused rotation of C-C bonds near Cu atoms. We discuss two driving forces, electron irradiation and in situ heating, and conclude that the observed transformations were mainly promoted by electron irradiation. Our results suggest that individual Cu atoms can promote reconstruction of single-layer graphene.

  5. Direct observation of stochastic domain-wall depinning in magnetic nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Im, Mi-Young; Bocklage, Lars; Fischer, Peter; Meier, Guido

    2008-11-01

    The stochastic field-driven depinning of a domain wall pinned at a notch in a magnetic nanowire is directly observed using magnetic X-ray microscopy with high lateral resolution down to 15 nm. The depinning-field distribution in Ni{sub 80}Fe{sub 20} nanowires considerably depends on the wire width and the notch depth. The difference in the multiplicity of domain-wall types generated in the vicinity of a notch is responsible for the observed dependence of the stochastic nature of the domain wall depinning field on the wire width and the notch depth. Thus the random nature of the domain wall depinning process is controllable by an appropriate design of the nanowire.

  6. Direct observation of superconducting gaps in MgB 2 by angle-resolved photoemission spectroscopy

    Science.gov (United States)

    Souma, S.; Machida, Y.; Sato, T.; Takahashi, T.; Matsui, H.; Wang, S.-C.; Ding, H.; Kaminski, A.; Campuzano, J. C.; Sasaki, S.; Kadowaki, K.

    2004-08-01

    High-resolution angle-resolved photoemission spectroscopy has been carried out to clarify the anomalous superconductivity of MgB 2. We observed three bands crossing the Fermi level, which are ascribed to B2p-σ, π and surface bands. We have succeeded for the first time in directly observing the superconducting gaps of these bands separately. We have found that the superconducting-gap sizes of σ and surface bands are 6.5 ± 0.5 and 6.0 ± 0.5 meV, respectively, while that of the π band is much smaller (1.5 ± 0.5 meV). The present experimental result unambiguously demonstrates the validity of the two-band superconductivity in MgB 2.

  7. Direct observation of superconducting gaps in MgB2 by angle-resolved photoemission spectroscopy

    International Nuclear Information System (INIS)

    Souma, S.; Machida, Y.; Sato, T.; Takahashi, T.; Matsui, H.; Wang, S.-C.; Ding, H.; Kaminski, A.; Campuzano, J.C.; Sasaki, S.; Kadowaki, K.

    2004-01-01

    High-resolution angle-resolved photoemission spectroscopy has been carried out to clarify the anomalous superconductivity of MgB 2 . We observed three bands crossing the Fermi level, which are ascribed to B2p-σ, π and surface bands. We have succeeded for the first time in directly observing the superconducting gaps of these bands separately. We have found that the superconducting-gap sizes of σ and surface bands are 6.5 ± 0.5 and 6.0 ± 0.5 meV, respectively, while that of the π band is much smaller (1.5 ± 0.5 meV). The present experimental result unambiguously demonstrates the validity of the two-band superconductivity in MgB 2

  8. Observation of Interactions in Adolescent Group Therapy: A Mixed Methods Study

    Directory of Open Access Journals (Sweden)

    Eulàlia Arias-Pujol

    2017-07-01

    Full Text Available Group psychotherapy is a useful clinical practice for adolescents with mental health issues. Groups typically consist of young people of similar ages but with different personalities, and this results in a complex communication network. The goal of group psychoanalytic psychotherapy is to improve participants' mentalization abilities, facilitating interactions between peers and their therapist in a safe, containing environment. The main aim of this study was to analyze conversation turn-taking between a lead therapist, a co-therapist, and six adolescents over the course of 24 treatment sessions divided into four blocks over 8 months. We employed a mixed-methods design based on systematic observation, which we consider to be a mixed method itself, as the qualitative data collected in the initial observation phase is transformed into quantitative data and subsequently interpreted qualitatively with the aid of clinical vignettes. The observational methodology design was nomothetic, follow-up, and multidimensional. The choice of methodology is justified as we used an ad-hoc observation instrument combining a field format and a category system. Interobserver agreement was analyzed quantitatively by Cohen's kappa using the free QSEQ5 software program. Once we had confirmed the reliability of the data, these were analyzed by polar coordinate analysis, which is a powerful data reduction technique that provides a vector representation of relationships between categories. The results show significant relationships between the therapist and (1 the activation of turn-taking by the participants and the co-therapist and silence and (2 conversation-facilitating interventions and interventions designed to improve mentalization abilities. Detailed analysis of questions demonstrating interest in others showed how the communication changed from radial interactions stemming from the therapist at the beginning of therapy to circular interactions half way through

  9. Group sessions with Paro in a nursing home: Structure, observations and interviews.

    Science.gov (United States)

    Robinson, Hayley; Broadbent, Elizabeth; MacDonald, Bruce

    2016-06-01

    We recently reported that a companion robot reduced residents' loneliness in a randomised controlled trial at an aged-care facility. This report aims to provide additional, previously unpublished data about how the sessions were run, residents' interactions with the robot and staff perspectives. Observations were conducted focusing on engagement, how residents treated the robot and if the robot acted as a social catalyst. In addition, 16 residents and 21 staff were asked open-ended questions at the end of the study about the sessions and the robot. Observations indicated that some residents engaged on an emotional level with Paro, and Paro was treated as both an agent and an artificial object. Interviews revealed that residents enjoyed sharing, interacting with and talking about Paro. This study supports other research showing Paro has psychosocial benefits and provides a guide for those wishing to use Paro in a group setting in aged care. © 2015 AJA Inc.

  10. Performing Gram stain directly on catheter tips: assessment of the quality of the observation process.

    Science.gov (United States)

    Guembe, M; Pérez-Granda, M J; Rivera, M L; Martín-Rabadán, P; Bouza, E

    2015-06-01

    A previous study performed in our institution showed that catheter tip (CT) staining by combining acridine orange and Gram stain (GS) before culture anticipated catheter colonization with exhaustive and careful observation by a highly trained technician. Our objective was to assess the validity values of GS without acridine orange on an external smear of CT for predicting catheter colonization and catheter-related bloodstream infection (C-RBSI). We compared different periods of observation and the results of two technicians with different levels of professional experience. Over a 5-month period, the roll-plate technique was preceded by direct GS of all CTs sent to the microbiology laboratory. The reading was taken at ×100 by two observers with different skill levels. Each observer performed a routine examination (3 min along three longitudinal lines) and an exhaustive examination (5 min along five longitudinal lines). The presence of at least one cell was considered positive. All slides were read before culture results were known. We included a total of 271 CTs from 209 patients. The prevalence of catheter colonization and C-RBSI was 16.2 % and 5.1 %, respectively. Routine and exhaustive examinations revealed only 29.5 % and 40.9 % of colonized catheters, respectively (p staining is performed exhaustively. However, the decision to implement this approach in daily routine will depend on the prevalence rate of catheter colonization at each institution.

  11. Direct Observation of the BCC (100) Plane in Thin Films of Sphere-forming Diblock Copolymers

    Science.gov (United States)

    Ji, Shengxiang; Nagpal, Umang; Liao, Wen; de Pablo, Juan; Nealey, Paul

    2010-03-01

    In sphere-forming diblock copolymers, periodic arrays of spheres are arranged in a body-centred cubic (BCC) lattice structure in bulk. However, in thin films different surface morphologies were observed as a function of the film thickness, and the transition from the hexagonal array to the BCC (110) arrangement of spheres on film surfaces was located with respect to the increase of the film thickness. Here we report the first direct observation of the BCC (100) plane in thin films of poly (styrene-b-methyl methacrylate) diblock copolymers on homogeneous substrates. By balancing the surface energies of both blocks, the lower energy BCC (100) plane corresponding to a square arrangement of half spheres, formed on film surfaces when the film thickness was commensurate with the spacing, L100, between (100) planes or greater than 2 L100. A hexagonal arrangement of spheres was only observed when the thickness was less than 2 L100 and incommensurate with 1 L100. Monte Carlo (MC) simulation confirmed our experimental observation and was used to investigate the transition of the arrangement of spheres as a function of the film thickness.

  12. Direct observation of forward-scattering oscillations in the H+HD→H2+D reaction

    Science.gov (United States)

    Yuan, Daofu; Yu, Shengrui; Chen, Wentao; Sang, Jiwei; Luo, Chang; Wang, Tao; Xu, Xin; Casavecchia, Piergiorgio; Wang, Xingan; Sun, Zhigang; Zhang, Dong H.; Yang, Xueming

    2018-06-01

    Accurate measurements of product state-resolved angular distributions are central to fundamental studies of chemical reaction dynamics. Yet, fine quantum-mechanical structures in product angular distributions of a reactive scattering process, such as the fast oscillations in the forward-scattering direction, have never been observed experimentally and the nature of these oscillations has not been fully explored. Here we report the crossed-molecular-beam experimental observation of these fast forward-scattering oscillations in the product angular distribution of the benchmark chemical reaction, H + HD → H2 + D. Clear oscillatory structures are observed for the H2(v' = 0, j' = 1, 3) product states at a collision energy of 1.35 eV, in excellent agreement with the quantum-mechanical dynamics calculations. Our analysis reveals that the oscillatory forward-scattering components are mainly contributed by the total angular momentum J around 28. The partial waves and impact parameters responsible for the forward scatterings are also determined from these observed oscillations, providing crucial dynamics information on the transient reaction process.

  13. Cloud-edge mixing: Direct numerical simulation and observations in Indian Monsoon clouds

    Science.gov (United States)

    Kumar, Bipin; Bera, Sudarsan; Prabha, Thara V.; Grabowski, Wojceich W.

    2017-03-01

    A direct numerical simulation (DNS) with the decaying turbulence setup has been carried out to study cloud-edge mixing and its impact on the droplet size distribution (DSD) applying thermodynamic conditions observed in monsoon convective clouds over Indian subcontinent during the Cloud Aerosol Interaction and Precipitation Enhancement EXperiment (CAIPEEX). Evaporation at the cloud-edges initiates mixing at small scale and gradually introduces larger-scale fluctuations of the temperature, moisture, and vertical velocity due to droplet evaporation. Our focus is on early evolution of simulated fields that show intriguing similarities to the CAIPEEX cloud observations. A strong dilution at the cloud edge, accompanied by significant spatial variations of the droplet concentration, mean radius, and spectral width, are found in both the DNS and in observations. In DNS, fluctuations of the mean radius and spectral width come from the impact of small-scale turbulence on the motion and evaporation of inertial droplets. These fluctuations decrease with the increase of the volume over which DNS data are averaged, as one might expect. In cloud observations, these fluctuations also come from other processes, such as entrainment/mixing below the observation level, secondary CCN activation, or variations of CCN activation at the cloud base. Despite large differences in the spatial and temporal scales, the mixing diagram often used in entrainment/mixing studies with aircraft data is remarkably similar for both DNS and cloud observations. We argue that the similarity questions applicability of heuristic ideas based on mixing between two air parcels (that the mixing diagram is designed to properly represent) to the evolution of microphysical properties during turbulent mixing between a cloud and its environment.

  14. [Preliminary study on detox in outpatient care units with 18 alcoholic patients in Directly Observed Treatment].

    Science.gov (United States)

    Lloréns Martínez, Ramón; Calatayud Francés, María; Morales Gallús, Esperanza; Añó Cervera, Consol; Adriá Caballero, Librada

    2008-01-01

    Directly Observed Treatment (TOD-DOT) has been tested in different conditions. The objective of this work is to check whether a UCA-CAB (Centre for Addictive Behaviour) can achieve detox and reduce the risk of early relapse (up to 12 weeks) in alcoholic patients. All patients had an established organic addiction and serious withdrawal syndrome, and had undergone multiple previous treatments. Furthermore, they had not managed to abstain for a 3-month consecutive period over the previous 2 years. The aim of the Directly Observed Treatment was to attain detox and reduce relapse by following a multi-method approach: medical, psychological and personal care, based on a brief daily consultation and pharmacological supervision. The results were as follows: Of the 18 patients included in the study, after 12 weeks, 13 (72 %) were still abstinent and 4 (22 %) had relapsed. Thus, 17 (94 %) were still following the treatment, with just one drop-out. We analysed the profiles of the patients abstaining, of those who relapsed (4) and of the one who dropped out. The average CIWA-Ar was 27.05 (21-36). Any value over 20 is considered to indicate serious withdrawal syndrome, though there were no negative events leading to hospitalization. Level of adherence to the treatment (94 %) meant that the most seriously affected patients and those with fewest financial resources could benefit, not only from any auxiliary social schemes, but also from basic health services, permitting them to improve the quality of their everyday life.

  15. Direct correlation of observed phonon anomalies and maxima in the generalized susceptibilities of transition metal carbides

    International Nuclear Information System (INIS)

    Gupta, M.; Freeman, A.J.

    1976-01-01

    The generalized susceptibility, chi(q vector), of both NbC and TaC determined from APW energy band calculations show large maxima to occur at precisely those q vector/sub max/ values at which soft phonon modes were observed by Smith. Maxima in chi (q vector) are predicted for other directions. The locus of these q vector/sub max/ values can be represented by a warped cube of dimension approximately 1.2 (2π/a) in momentum space, in striking agreement with the soft mode surface proposed phenomenologically by Weber. In sharp contrast, the chi(q vector) calculated for both ZrC and HfC (for which no phonon anomalies have been observed) fall off in all symmetry directions away from the zone center. The phonon anomalies in the transition metal carbides are interpreted as due to an ''overscreening'' effect resulting from an anomalous increase of the response function of the conduction electrons. 8 figures, 41 references

  16. DIRECT OBSERVATION OF SOLAR CORONAL MAGNETIC FIELDS BY VECTOR TOMOGRAPHY OF THE CORONAL EMISSION LINE POLARIZATIONS

    International Nuclear Information System (INIS)

    Kramar, M.; Lin, H.; Tomczyk, S.

    2016-01-01

    We present the first direct “observation” of the global-scale, 3D coronal magnetic fields of Carrington Rotation (CR) Cycle 2112 using vector tomographic inversion techniques. The vector tomographic inversion uses measurements of the Fe xiii 10747 Å Hanle effect polarization signals by the Coronal Multichannel Polarimeter (CoMP) and 3D coronal density and temperature derived from scalar tomographic inversion of Solar Terrestrial Relations Observatory (STEREO)/Extreme Ultraviolet Imager (EUVI) coronal emission lines (CELs) intensity images as inputs to derive a coronal magnetic field model that best reproduces the observed polarization signals. While independent verifications of the vector tomography results cannot be performed, we compared the tomography inverted coronal magnetic fields with those constructed by magnetohydrodynamic (MHD) simulations based on observed photospheric magnetic fields of CR 2112 and 2113. We found that the MHD model for CR 2112 is qualitatively consistent with the tomography inverted result for most of the reconstruction domain except for several regions. Particularly, for one of the most noticeable regions, we found that the MHD simulation for CR 2113 predicted a model that more closely resembles the vector tomography inverted magnetic fields. In another case, our tomographic reconstruction predicted an open magnetic field at a region where a coronal hole can be seen directly from a STEREO-B/EUVI image. We discuss the utilities and limitations of the tomographic inversion technique, and present ideas for future developments

  17. Direct observation of weight-related communication in primary care: a systematic review.

    Science.gov (United States)

    McHale, Calum T; Laidlaw, Anita H; Cecil, Joanne E

    2016-08-01

    Primary care is ideally placed to play an effective role in patient weight management; however, patient weight is seldom discussed in this context. A synthesis of studies that directly observe weight discussion in primary care is required to more comprehensively understand and improve primary care weight-related communication. To systematically identify and examine primary care observational research that investigates weight-related communication and its relationship to patient weight outcomes. A systematic review of literature published up to August 2015, using seven electronic databases (including MEDLINE, Scopus and PsycINFO), was conducted using search terms such as overweight, obese and/or doctor-patient communication. Twenty papers were included in the final review. Communication analysis focused predominantly on 'practitioner' use of specific patient-centred communication. Practitioner use of motivational interviewing was associated with improved patient weight-related outcomes, including patient weight loss and increased patient readiness to lose weight; however, few studies measured patient weight-related outcomes. Studies directly observing weight-related communication in primary care are scarce and limited by a lack of focus on patient communication and patient weight-related outcomes. Future research should measure practitioner and patient communications during weight discussion and their impact on patient weight-related outcomes. This knowledge may inform the development of a communication intervention to assist practitioners to more effectively discuss weight with their overweight and/or obese patients. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  18. Ground-Based Observations of Terrestrial Gamma Ray Flashes Associated with Downward-Directed Lightning Leaders

    Science.gov (United States)

    Belz, J.; Abbasi, R.; Krehbiel, P. R.; LeVon, R.; Remington, J.; Rison, W.; Thomas, R. J.

    2017-12-01

    and energy measurement, simulation studies indicate that the fluxes and forward-beaming observed are consistent with production in processes such as the relativistic runaway electron avalanche. We conclude that the anomalous triggers observed by TA are most likely downward-directed Terrestrial Gamma Flashes.

  19. Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

    Directory of Open Access Journals (Sweden)

    Call Jerry

    2012-03-01

    Full Text Available Abstract Background Gastrointestinal stromal tumors (GIST, one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or leiomyoblastomas. Since the advent of imatinib, GIST has been further delineated into adult- (KIT or PDGFRα mutations and pediatric- (typified by wild-type GIST/succinate dehydrogenase deficiencies types. Using varying gender ratios at age of diagnosis we sought to elucidate prognostic factors for each sub-type and their impact on overall survival. Methods This is a long-term retrospective analysis of a large observational study of an international open cohort of patients from a GIST research and patient advocacy's lifetime registry. Demographic and disease-specific data were voluntarily supplied by its members from May 2000-October 2010; the primary outcome was overall survival. Associations between survival and prognostic factors were evaluated by univariate Cox proportional hazard analyses, with backward selection at P Results Inflections in gender ratios by age at diagnosis in years delineated two distinct groups: above and below age 35 at diagnosis. Closer analysis confirmed the above 35 age group as previously reported for adult-type GIST, typified by mixed primary tumor sites and gender, KIT or PDGFRα mutations, and shorter survival times. The pediatric group ( Conclusions Pediatric- and adult-type GIST have been previously characterized in clinical settings and these observations confirm significant prognostic factors for each from a diverse real-world cohort. Additionally, these findings suggest that extra diligence be taken with "young adults" (aged 18-35 at diagnosis as pediatric-type GIST may present well beyond adolescence, particularly as these distinct sub-types have different causes, and consequently

  20. Photoelectron binding energy shifts observed during oxidation of group IIA, IIIA and IVA elemental surfaces

    International Nuclear Information System (INIS)

    Heide, P.A.W. van der

    2006-01-01

    An extensive re-evaluation of XPS binding energies (BE's) and binding energy shifts (ΔBE's) from metals, oxides and the carbonates of the group II, III and IVA elements (exceptions are Be, Mg and Hf) has been carried out using a substrate specific BE referencing approach. From this, O-1s BE's are found to fall into surface oxide, bulk oxide and carbonate groupings, with bulk oxides showing the lowest BE's followed by surface oxides (+∼1.5 eV) and then carbonates (+∼3.0 eV). The O-1s BE's from the bulk oxides also appear to scale with 1/d, where d is inter-atomic distance. The same is noted in the ΔBE's observed from the metallic counterparts during oxidation of the elemental surfaces. This, and the decreasing BE exhibited by Ca, Sr and Ba on oxidation is explained within the charge potential model as resulting from competing inter- and intra-atomic effects, and is shown to be consistent with partial covalency arguments utilizing Madulung potentials. The ΔBE's also fall into groups according to the elements location in the periodic table, i.e. s, p or d block. These trends open up the possibility of approximating ΔBE's arising from initial and final state effects, and bond distances

  1. Direct immobilization and hybridization of DNA on group III nitride semiconductors

    Energy Technology Data Exchange (ETDEWEB)

    Xu Xiaobin; Jindal, Vibhu; Shahedipour-Sandvik, Fatemeh; Bergkvist, Magnus [College of Nanoscale Science and Engineering, University at Albany (SUNY), 255 Fuller Road, Albany, NY 12203 (United States); Cady, Nathaniel C. [College of Nanoscale Science and Engineering, University at Albany (SUNY), 255 Fuller Road, Albany, NY 12203 (United States)], E-mail: ncady@uamail.albany.edu

    2009-03-15

    A key concern for group III-nitride high electron mobility transistor (HEMT) biosensors is the anchoring of specific capture molecules onto the gate surface. To this end, a direct immobilization strategy was developed to attach single-stranded DNA (ssDNA) to AlGaN surfaces using simple printing techniques without the need for cross-linking agents or complex surface pre-functionalization procedures. Immobilized DNA molecules were stably attached to the AlGaN surfaces and were able to withstand a range of pH and ionic strength conditions. The biological activity of surface-immobilized probe DNA was also retained, as demonstrated by sequence-specific hybridization experiments. Probe hybridization with target ssDNA could be detected by PicoGreen fluorescent dye labeling with a minimum detection limit of 2 nM. These experiments demonstrate a simple and effective immobilization approach for attaching nucleic acids to AlGaN surfaces which can further be used for the development of HEMT-based DNA biosensors.

  2. Mutagenic Organized Recombination Process by Homologous IN vivo Grouping (MORPHING) for directed enzyme evolution.

    Science.gov (United States)

    Gonzalez-Perez, David; Molina-Espeja, Patricia; Garcia-Ruiz, Eva; Alcalde, Miguel

    2014-01-01

    Approaches that depend on directed evolution require reliable methods to generate DNA diversity so that mutant libraries can focus on specific target regions. We took advantage of the high frequency of homologous DNA recombination in Saccharomyces cerevisiae to develop a strategy for domain mutagenesis aimed at introducing and in vivo recombining random mutations in defined segments of DNA. Mutagenic Organized Recombination Process by Homologous IN vivo Grouping (MORPHING) is a one-pot random mutagenic method for short protein regions that harnesses the in vivo recombination apparatus of yeast. Using this approach, libraries can be prepared with different mutational loads in DNA segments of less than 30 amino acids so that they can be assembled into the remaining unaltered DNA regions in vivo with high fidelity. As a proof of concept, we present two eukaryotic-ligninolytic enzyme case studies: i) the enhancement of the oxidative stability of a H2O2-sensitive versatile peroxidase by independent evolution of three distinct protein segments (Leu28-Gly57, Leu149-Ala174 and Ile199-Leu268); and ii) the heterologous functional expression of an unspecific peroxygenase by exclusive evolution of its native 43-residue signal sequence.

  3. Simultaneous recording of electroretinogram and visual evoked response. Focal stimulation under direct observation.

    Science.gov (United States)

    Hirose, T; Miyake, Y; Hara, A

    1977-07-01

    A system has been tested that allows simultaneous recording of the retinal response (electroretinogram [ERG]) and the occipital response (visual evoked response [VER]) with focal photic stimulation of the retina under direct observation of the fundus. A helium-neon gas laser is used as a stimulus source. The laser is chopped either by a pen motor or a rotating disc. The laser is attached to a biomicroscope through which the examiner can observe the fundus of the subject during the entire recording session. The optically clear contact lens is made with a flat surface that neutralizes refraction due to the cornea, thereby allowing fundus observation by microscope. Two metal wires mounted inside and outside of the lens serve as the electrode for the ERG. Graticules consisting of concentric circles and radial lines are projected onto the subject's fundus, providing a pattern that the examiner can use to determine the exact location to be stimulated in the fundus. With proper adjustment of stimulus and background illumination, local ERG and VER can be recorded simultaneously by stimulating the macula.

  4. Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study.

    Science.gov (United States)

    Jun, Min; Lix, Lisa M; Durand, Madeleine; Dahl, Matt; Paterson, J Michael; Dormuth, Colin R; Ernst, Pierre; Yao, Shenzhen; Renoux, Christel; Tamim, Hala; Wu, Cynthia; Mahmud, Salaheddin M; Hemmelgarn, Brenda R

    2017-10-17

    Objective  To determine the safety of direct oral anticoagulant (DOAC) use compared with warfarin use for the treatment of venous thromboembolism. Design  Retrospective matched cohort study conducted between 1 January 2009 and 31 March 2016. Setting  Community based, using healthcare data from six jurisdictions in Canada and the United States. Participants  59 525 adults (12 489 DOAC users; 47 036 warfarin users) with a new diagnosis of venous thromboembolism and a prescription for a DOAC or warfarin within 30 days of diagnosis. Main outcome measures  Outcomes included hospital admission or emergency department visit for major bleeding and all cause mortality within 90 days after starting treatment. Propensity score matching and shared frailty models were used to estimate adjusted hazard ratios of the outcomes comparing DOACs with warfarin. Analyses were conducted independently at each site, with meta-analytical methods used to estimate pooled hazard ratios across sites. Results  Of the 59 525 participants, 1967 (3.3%) had a major bleed and 1029 (1.7%) died over a mean follow-up of 85.2 days. The risk of major bleeding was similar for DOAC compared with warfarin use (pooled hazard ratio 0.92, 95% confidence interval 0.82 to 1.03), with the overall direction of the association favouring DOAC use. No difference was found in the risk of death (pooled hazard ratio 0.99, 0.84 to 1.16) for DOACs compared with warfarin use. There was no evidence of heterogeneity across centres, between patients with and without chronic kidney disease, across age groups, or between male and female patients. Conclusions  In this analysis of adults with incident venous thromboembolism, treatment with DOACs, compared with warfarin, was not associated with an increased risk of major bleeding or all cause mortality in the first 90 days of treatment. Trial registration  Clinical trials NCT02833987. Published by the BMJ Publishing Group Limited. For permission to use (where not

  5. Generating Lie Point Symmetry Groups of (2+1)-Dimensional Broer-Kaup Equation via a Simple Direct Method

    International Nuclear Information System (INIS)

    Ma Hongcai

    2005-01-01

    Using the (2+1)-dimensional Broer-Kaup equation as an simple example, a new direct method is developed to find symmetry groups and symmetry algebras and then exact solutions of nonlinear mathematical physical equations.

  6. The colour of thermal noise in classical Brownian motion: a feasibility study of direct experimental observation

    International Nuclear Information System (INIS)

    Berg-Soerensen, Kirstine; Flyvbjerg, Henrik

    2005-01-01

    One hundred years after Einstein modelled Brownian motion, a central aspect of this motion in incompressible fluids has not been verified experimentally: the thermal noise that drives the Brownian particle, is not white, as in Einstein's simple theory. It is slightly coloured, due to hydrodynamics and the fluctuation-dissipation theorem. This theoretical result from the 1970s was prompted by computer simulation results in apparent violation of Einstein's theory. We discuss how a direct experimental observation of this colour might be carried out by using optical tweezers to separate the thermal noise from the particle's dynamic response to it. Since the thermal noise is almost white, very good statistics is necessary to resolve its colour. That requires stable equipment and long recording times, possibly making this experiment one for the future only. We give results for experimental requirements and for stochastic errors as functions of experimental window and measurement time, and discuss some potential sources of systematic errors

  7. Direct observations of American eels migrating across the continental shelf to the Sargasso Sea.

    Science.gov (United States)

    Béguer-Pon, Mélanie; Castonguay, Martin; Shan, Shiliang; Benchetrit, José; Dodson, Julian J

    2015-10-27

    Since inferring spawning areas from larval distributions in the Sargasso Sea a century ago, the oceanic migration of adult American eels has remained a mystery. No adult eel has ever been observed migrating in the open ocean or in the spawning area. Here, we track movements of maturing eels equipped with pop-up satellite archival tags from the Scotian Shelf (Canada) into the open ocean, with one individual migrating 2,400 km to the northern limit of the spawning site in the Sargasso Sea. The reconstructed routes suggest a migration in two phases: one over the continental shelf and along its edge in shallow waters; the second in deeper waters straight south towards the spawning area. This study is the first direct evidence of adult Anguilla migrating to the Sargasso Sea and represents an important step forward in the understanding of routes and migratory cues.

  8. Direct quantum process tomography via measuring sequential weak values of incompatible observables.

    Science.gov (United States)

    Kim, Yosep; Kim, Yong-Su; Lee, Sang-Yun; Han, Sang-Wook; Moon, Sung; Kim, Yoon-Ho; Cho, Young-Wook

    2018-01-15

    The weak value concept has enabled fundamental studies of quantum measurement and, recently, found potential applications in quantum and classical metrology. However, most weak value experiments reported to date do not require quantum mechanical descriptions, as they only exploit the classical wave nature of the physical systems. In this work, we demonstrate measurement of the sequential weak value of two incompatible observables by making use of two-photon quantum interference so that the results can only be explained quantum physically. We then demonstrate that the sequential weak value measurement can be used to perform direct quantum process tomography of a qubit channel. Our work not only demonstrates the quantum nature of weak values but also presents potential new applications of weak values in analyzing quantum channels and operations.

  9. Direct observation of hierarchical nucleation of martensite and size-dependent superelasticity in shape memory alloys.

    Science.gov (United States)

    Liu, Lifeng; Ding, Xiangdong; Li, Ju; Lookman, Turab; Sun, Jun

    2014-02-21

    Martensitic transformation usually creates hierarchical internal structures beyond mere change of the atomic crystal structure. Multi-stage nucleation is thus required, where nucleation (level-1) of the underlying atomic crystal lattice does not have to be immediately followed by the nucleation of higher-order superstructures (level-2 and above), such as polysynthetic laths. Using in situ transmission electron microscopy (TEM), we directly observe the nucleation of the level-2 superstructure in a Cu-Al-Ni single crystal under compression, with critical super-nuclei size L2c around 500 nm. When the sample size D decreases below L2c, the superelasticity behavior changes from a flat stress plateau to a continuously rising stress-strain curve. Such size dependence definitely would impact the application of shape memory alloys in miniaturized MEMS/NEMS devices.

  10. Nursing performance in the policy transfer of directly observed treatment of tuberculosis

    Directory of Open Access Journals (Sweden)

    Káren Mendes Jorge de Souza

    2014-10-01

    Full Text Available Objective Analyzing the policy transfer of directly observed treatment of tuberculosis from the perspective of nursing. Method This is a descriptive study with qualitative approach, which had 10 nurses of the Family Health Strategy in São Paulo as subjects. The interviews were carried out between May and June 2013, and were adopted the technique of thematic content analysis and the referential of policy transfer. Results On the signification of this treatment, are related the senses of disciplinary monitoring, the bond and approximation to the context of patients’ lives. Operationally, nurses, community health agents and nursing technicians stand out as agents of implementation of this policy, developing multiple actions of user embracement. The nurse is evidenced as an educator in health, leader in the family health team, and capable of creating emotional bond with users. Conclusion It was found that the innovations proposed in the treatment are incipient in the daily work of nurses.

  11. [Nursing performance in the policy transfer of directly observed treatment of tuberculosis].

    Science.gov (United States)

    Souza, Káren Mendes Jorge de; Sá, Lenilde Duarte de; Silva, Laís Mara Caetano da; Palha, Pedro Fredemir

    2014-10-01

    Analyzing the policy transfer of directly observed treatment of tuberculosis from the perspective of nursing. This is a descriptive study with qualitative approach, which had 10 nurses of the Family Health Strategy in São Paulo as subjects. The interviews were carried out between May and June 2013, and were adopted the technique of thematic content analysis and the referential of policy transfer. On the signification of this treatment, are related the senses of disciplinary monitoring, the bond and approximation to the context of patients' lives. Operationally, nurses, community health agents and nursing technicians stand out as agents of implementation of this policy, developing multiple actions of user embracement. The nurse is evidenced as an educator in health, leader in the family health team, and capable of creating emotional bond with users. It was found that the innovations proposed in the treatment are incipient in the daily work of nurses.

  12. Direct Observation of Energy Detrapping in LH1-RC Complex by Two-Dimensional Electronic Spectroscopy.

    Science.gov (United States)

    Ma, Fei; Yu, Long-Jiang; Hendrikx, Ruud; Wang-Otomo, Zheng-Yu; van Grondelle, Rienk

    2017-01-18

    The purple bacterial core light harvesting antenna-reaction center (LH1-RC) complex is the simplest system able to achieve the entire primary function of photosynthesis. During the past decade, a variety of photosynthetic proteins were studied by a powerful technique, two-dimensional electronic spectroscopy (2DES). However, little attention has been paid to LH1-RC, although its reversible uphill energy transfer, trapping, and backward detrapping processes, represent a crucial step in the early photosynthetic reaction dynamics. Thus, in this work, we employed 2DES to study two LH1-RC complexes of Thermochromatium (Tch.) tepidum. By direct observation of detrapping, the complex reversible process was clearly identified and an overall scheme of the excitation evolution in LH1-RC was obtained.

  13. Direct observations of the charge states of low energy solar particles

    Science.gov (United States)

    Gloeckler, G.; Fan, C. Y.; Hovestadt, D.

    1974-01-01

    The charge states of carbon and oxygen of solar origin have been measured directly in interplanetary space. At 100 keV per nucleon the C(+5)/C(+6) and O(+7)/O(+8) ratios are 1.8 and 1.6, respectively. Abundance ratios of low energy heavy nuclei to He are found which are significantly larger than the corresponding photospheric values. The enhancement of O/He is 35, and both Si/He and Fe/He are overabundant by a factor of 100. To explain these observations a mechanism is proposed which first preferentially accelerates heavy ions and is followed by either storage of these ions in the coronal regions or strong adiabatic deceleration.

  14. Optimization study of direct morphology observation by cold field emission SEM without gold coating.

    Science.gov (United States)

    He, Dan; Fu, Cheng; Xue, Zhigang

    2018-06-01

    Gold coating is a general operation that is generally applied on non-conductive or low conductive materials, during which the morphology of the materials can be examined by scanning electron microscopy (SEM). However, fatal deficiencies in the materials can result in irreversible distortion and damage. The present study directly characterized different low conductive materials such as hydroxyapatite, modified poly(vinylidene fluoride) (PVDF) fiber, and zinc oxide nanopillar by cold field emission scanning electron microscopy (FE-SEM) without a gold coating. According to the characteristics of the low conductive materials, various test conditions, such as different working signal modes, accelerating voltages, electron beam spots, and working distances, were characterized to determine the best morphological observations of each sample. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

    International Nuclear Information System (INIS)

    Call, Jerry; Walentas, Christopher D; Eickhoff, Jens C; Scherzer, Norman

    2012-01-01

    Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or leiomyoblastomas. Since the advent of imatinib, GIST has been further delineated into adult- (KIT or PDGFRα mutations) and pediatric- (typified by wild-type GIST/succinate dehydrogenase deficiencies) types. Using varying gender ratios at age of diagnosis we sought to elucidate prognostic factors for each sub-type and their impact on overall survival. This is a long-term retrospective analysis of a large observational study of an international open cohort of patients from a GIST research and patient advocacy's lifetime registry. Demographic and disease-specific data were voluntarily supplied by its members from May 2000-October 2010; the primary outcome was overall survival. Associations between survival and prognostic factors were evaluated by univariate Cox proportional hazard analyses, with backward selection at P < 0.05 used to identify independent factors. Inflections in gender ratios by age at diagnosis in years delineated two distinct groups: above and below age 35 at diagnosis. Closer analysis confirmed the above 35 age group as previously reported for adult-type GIST, typified by mixed primary tumor sites and gender, KIT or PDGFRα mutations, and shorter survival times. The pediatric group (< age 18 at diagnosis) was also as previously reported with predominantly stomach tumors, females, wild-type GIST or SDH mutations, and extended survival. 'Young adults' however formed a third group aged 18-35 at diagnosis, and were a clear mix of these two previously reported distinct sub-types. Pediatric- and adult-type GIST have been previously characterized in clinical settings and these observations confirm significant prognostic factors for each

  16. Detecting frontal ablation processes from direct observations of submarine terminus morphology

    Science.gov (United States)

    Fried, M.; Carroll, D.; Catania, G. A.; Sutherland, D. A.; Stearns, L. A.; Bartholomaus, T. C.; Shroyer, E.; Nash, J. D.

    2017-12-01

    Tidewater glacier termini couple glacier and ocean systems. Subglacial discharge emerging from the terminus produces buoyant plumes that modulate submarine melting, calving, fjord circulation and, in turn, changes in ice dynamics from back-stress perturbations. However, the absence of critical observational data at the ice-ocean interface limits plume and, by extension, melt models from incorporating realistic submarine terminus face morphologies and assessing their impact on terminus behavior at tidewater glaciers. Here we present a comprehensive inventory and characterization of submarine terminus face shapes from a side-looking, multibeam echo sounding campaign across Kangerdlugssuaq Sermerssua glacier, central-west Greenland. We combine these observations with in-situ measurements of ocean stratification and remotely sensed subglacial discharge, terminus positions, ice velocity, and ice surface datasets to infer the spectrum of processes sculpting the submarine terminus face. Subglacial discharge outlet locations are confirmed through observations of sediment plumes, localized melt-driven undercutting of the terminus face, and bathymetry of the adjacent seafloor. From our analysis, we differentiate terminus morphologies resulting from submarine melt and calving and assess the contribution of each process to the net frontal ablation budget. Finally, we constrain a plume model using direct observations of the submarine terminus face and conduit geometry. Plume model simulations demonstrate that the majority of discharge outlets are fed by small discharge fluxes, suggestive of a distributed subglacial hydrologic system. Outlets with the largest, concentrated discharge fluxes are morphologically unique and strongly control seasonal terminus position. At these locations, we show that the spatiotemporal pattern of terminus retreat is well correlated with time periods when local melt rate exceeds ice velocity.

  17. Direct observation of the nutrition care practices of Australian general practitioners

    Directory of Open Access Journals (Sweden)

    Ball LE

    2014-06-01

    Full Text Available INTRODUCTION: Nutrition care refers to nutrition-related advice or counselling provided by health professionals in an attempt to improve the nutrition behaviour of patients. AIM: The aim of this study was to describe the practices of a sample of Australian general practitioners (GPs when providing nutrition care to adult patients. METHODS: Eighteen GPs (13 male, 5 female were observed by fourth-year medical students during their general practice rotation. Each GP was observed for five consultations that included nutrition care, totalling 90 observed consultations. In each consultation, students completed a 31-item nutrition care checklist of nutrition care practices that could feasibly occur in a standard consultation. Each practice was marked with either a ‘yes’ (completed, ‘no’ (did not complete or ‘completed by practice nurse prior to or after the consultation’. RESULTS: Twenty-eight nutrition care practices were observed at least once. The most frequently observed practices were measuring and discussing blood pressure (76.7%; n=69, followed by general questions about current diet (74.4%; n=67. Approximately half of the consultations included a statement of a nutrition-related problem (52.2%; n=47, and the provision of nutrition advice that focused on a nutrient (45.6%; n=41 or food group (52.2%; n=47. Consultations with male GPs, as well as GPs with more than 25 years of experience, were associated with an increased number of nutrition care practices per consultation. DISCUSSION: The GPs performed nutrition care practices in varying frequencies. Further research is required to identify the most effective GP nutrition care practices to improve the nutrition behaviour of patients.

  18. Evaluation of the implementation of the directly observed treatment strategy for tuberculosis in a large city.

    Science.gov (United States)

    Lavôr, Débora Cristina Brasil da Silva; Pinheiro, Jair Dos Santos; Gonçalves, Maria Jacirema Ferreira

    2016-04-01

    To assess the degree of implementation of the Directly Observed Treatment, Short-course - DOTS for tuberculosis (TB) in a large city. Assessment of the implementation of the logic model, whose new cases of infectious pulmonary TB were recruited from specialized clinics and followed-up in basic health units. The judgment matrix covering the five components of the DOTS strategy were used. The result of the logic model indicates DOTS was partially implemented. In external, organizational and implementation contexts, the DOTS strategy was partially implemented; and, the effectiveness was not implemented. The partial implementation of the DOTS strategy in the city of Manaus did not reflect in TB control compliance, leading to low effectiveness of the program. Avaliar o grau de implantação da estratégia de tratamento diretamente observado (Directly Observed Treatment, Short-course - DOTS) para tuberculose (TB) em um município de grande porte. Avaliação de implantação por meio de modelo lógico, cujos casos novos de TB pulmonar bacilífera foram recrutados em ambulatórios especializados e acompanhados nas unidades básicas de saúde. Utilizou-se matriz de julgamento que abrange os cinco componentes da estratégia DOTS. O resultado do modelo lógico indica DOTS implantada parcialmente. Nos contextos externo, organizacional e de implantação, a estratégia DOTS está implantada parcialmente; e, na efetividade não está implantada. A implantação parcial da estratégia DOTS, na cidade de Manaus, reflete na não conformidade do controle da TB, levando à baixa efetividade do programa.

  19. Direct radiative feedback due to biogenic secondary organic aerosol estimated from boreal forest site observations

    International Nuclear Information System (INIS)

    Lihavainen, Heikki; Asmi, Eija; Aaltonen, Veijo; Makkonen, Ulla; Kerminen, Veli-Matti

    2015-01-01

    We used more than five years of continuous aerosol measurements to estimate the direct radiative feedback parameter associated with the formation of biogenic secondary organic aerosol (BSOA) at a remote continental site at the edge of the boreal forest zone in Northern Finland. Our upper-limit estimate for this feedback parameter during the summer period (ambient temperatures above 10 °C) was −97 ± 66 mW m −2 K −1 (mean ± STD) when using measurements of the aerosol optical depth (f AOD ) and −63 ± 40 mW m −2 K −1 when using measurements of the ‘dry’ aerosol scattering coefficient at the ground level (f σ ). Here STD represents the variability in f caused by the observed variability in the quantities used to derive the value of f. Compared with our measurement site, the magnitude of the direct radiative feedback associated with BSOA is expected to be larger in warmer continental regions with more abundant biogenic emissions, and even larger in regions where biogenic emissions are mixed with anthropogenic pollution. (letter)

  20. Direct Single-Molecule Observation of Mode and Geometry of RecA-Mediated Homology Search.

    Science.gov (United States)

    Lee, Andrew J; Endo, Masayuki; Hobbs, Jamie K; Wälti, Christoph

    2018-01-23

    Genomic integrity, when compromised by accrued DNA lesions, is maintained through efficient repair via homologous recombination. For this process the ubiquitous recombinase A (RecA), and its homologues such as the human Rad51, are of central importance, able to align and exchange homologous sequences within single-stranded and double-stranded DNA in order to swap out defective regions. Here, we directly observe the widely debated mechanism of RecA homology searching at a single-molecule level using high-speed atomic force microscopy (HS-AFM) in combination with tailored DNA origami frames to present the reaction targets in a way suitable for AFM-imaging. We show that RecA nucleoprotein filaments move along DNA substrates via short-distance facilitated diffusions, or slides, interspersed with longer-distance random moves, or hops. Importantly, from the specific interaction geometry, we find that the double-stranded substrate DNA resides in the secondary DNA binding-site within the RecA nucleoprotein filament helical groove during the homology search. This work demonstrates that tailored DNA origami, in conjunction with HS-AFM, can be employed to reveal directly conformational and geometrical information on dynamic protein-DNA interactions which was previously inaccessible at an individual single-molecule level.

  1. Direct Observation of Virtual Electrode Formation Through a Novel Electrolyte-to-Electrode Transition

    Science.gov (United States)

    Siegel, David; El Gabaly, Farid; Bartelt, Norman; McCarty, Kevin

    2014-03-01

    Novel electrochemical solutions to problems in energy storage and transportation can drive renewable energy to become an economically viable alternative to fossil fuels. In many electrochemical systems, the behavior of a device can be fundamentally limited by the surface area of a triple phase boundary, the boundary region where a gas-phase species, electrode, and electrolyte coincide. When the electrode is an ionic insulator the triple phase boundary is typically a one-dimensional boundary with nanometer-scale thickness: ions cannot transport through the electrode, while electrons cannot be transported through the electrolyte. Here we present direct experimental measurements of a novel electrolyte-to-electrode transition with photoemission electron microscopy, and observe that the surface of an ionically conductive, electronically insulative solid oxide electrolyte undergoes a transition into a mixed electron-ion conductor in the vicinity of a metal electrode. Our direct experimental measurements allow us to characterize this system and address the mechanisms of ionic reactions and transport through comparisons with theoretical modeling to provide us with a physical picture of the processes involved. Our results provide insight into one of the mechanisms of ion transport in an electrochemical cell that may be generalizable to other systems.

  2. Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function.

    Directory of Open Access Journals (Sweden)

    Mary E Hensler

    Full Text Available BACKGROUND: Group B Streptococcus (GBS is a leading cause of neonatal sepsis where myocardial dysfunction is an important contributor to poor outcome. Here we study the effects of the GBS pore-forming beta-hemolysin/cytolysin (Bh/c exotoxin on cardiomyocyte viability, contractility, and calcium transients. METHODOLOGY/PRINCIPAL FINDINGS: HL-1 cardiomyocytes exposed to intact wild-type (WT or isogenic Deltabeta h/c mutant GBS, or to cell-free extracts from either strain, were assessed for viability by trypan blue exclusion and for apoptosis by TUNEL staining. Functionality of exposed cardiomyocytes was analyzed by visual quantitation of the rate and extent of contractility. Mitochondrial membrane polarization was measured in TMRE-loaded cells exposed to GBS beta h/c. Effects of GBS beta h/c on calcium transients were studied in fura-2AM-loaded primary rat ventricular cardiomyocytes. Exposure of HL-1 cardiomyocytes to either WT GBS or beta h/c extracts significantly reduced both rate and extent of contractility and later induced necrotic and apoptotic cell death. No effects on cardiomyocyte viability or function were observed after treatment with Deltabeta h/c mutant bacteria or extracts. The beta h/c toxin was associated with complete and rapid loss of detectable calcium transients in primary neonatal rat ventricular cardiomyocytes and induced a loss of mitochondrial membrane polarization. These effects on viability and function were abrogated by the beta h/c inhibitor, dipalmitoyl phosphatidylcholine (DPPC. CONCLUSIONS/SIGNIFICANCE: Our data show a rapid loss of cardiomyocyte viability and function induced by GBS beta h/c, and these deleterious effects are inhibited by DPPC, a normal constituent of human pulmonary surfactant.. These findings have clinical implications for the cardiac dysfunction observed in neonatal GBS infections.

  3. Directionality of Cation/Molecule Bonding in Lewis Bases Containing the Carbonyl Group.

    Science.gov (United States)

    Valadbeigi, Younes; Gal, Jean-François

    2017-09-14

    Relationship between the C═O-X + (X = H, Li, Na, K, Al, Cu) angle and covalent characteristic of the X + -M (M = CH 2 O, CH 3 CHO, acetone, imidazol-2-one (C 2 H 2 N 2 O), cytosine, γ-butyrolactone) was investigated, theoretically. The calculated electron densities ρ at the bond critical points revealed that the covalency of the M-X + interaction depended on the nature of the cation and varied as H + > Cu + > Al + > Li + > Na + > K + . The alkali cations tended to participate in electrostatic interactions and aligned with the direction of the molecule dipole or local dipole of C═O group to form linear C═O-X geometries. Because of overlapping with lone-pair electrons of the sp 2 carbonyl oxygen, the H + and Cu + formed a bent C═O-X angle. Al + displayed an intermediate behavior; the C═O-Al angle was 180° in [CH 2 O/Al] + (mainly electrostatic), but when the angle was bent (146°) under the effect of local dipole of an adjacent imine group in cytosine, the covalency of the CO-Al + interaction increased. The C═O-X angles in M/X + adduct ions were scanned in different O-X bond lengths. It was found that the most favorable C═O-X angle depended on the O-X bond length. This dependency was attributed to variation of covalent and electrostatic contributions with O-X distance. In addition, the structures of [CH 2 S/X] + and [CH 2 Se/X] + were studied, and only bent C═S-X and C═Se-X angles were obtained for all cations, although the dipole vectors of CH 2 S and CH 2 Se coincide with the C═S and C═Se bonds. The bending of the C═S-X and C═Se-X angles was attributed to the covalent characteristic of S-X and Se-X interactions due to high polarizability of S and Se atoms.

  4. Mandatory Nap Times and Group Napping Patterns in Child Care: An Observational Study.

    Science.gov (United States)

    Staton, Sally L; Smith, Simon S; Hurst, Cameron; Pattinson, Cassandra L; Thorpe, Karen J

    2017-01-01

    Policy provision for naps is typical in child care settings, but there is variability in the practices employed. One practice that might modify children's early sleep patterns is the allocation of a mandatory nap time in which all children are required to lie on their beds without alternate activity permitted. There is currently limited evidence of the effects of such practices on children's napping patterns. This study examined the association between duration of mandatory nap times and group-level napping patterns in child care settings. Observations were undertaken in a community sample of 113 preschool rooms with a scheduled nap time (N = 2,114 children). Results showed that 83.5% of child care settings implemented a mandatory nap time (range = 15-145 min) while 14.2% provided alternate activities for children throughout the nap time period. Overall, 31% of children napped during nap times. Compared to rooms with ≤ 30 min of mandatory nap time, rooms with 31-60 min and > 60 min of mandatory nap time had a two-and-a-half and fourfold increase, respectively, in the proportion of children napping. Nap onset latency did not significantly differ across groups. Among preschool children, exposure to longer mandatory nap times in child care may increase incidence of napping.

  5. Direct observations of the Antarctic Slope Current transport at 113°E

    Science.gov (United States)

    Peña-Molino, B.; McCartney, M. S.; Rintoul, S. R.

    2016-10-01

    The Antarctic Slope Current (ASC), defined here as the region of westward flow along the continental slope off Antarctica, forms the southern limb of the subpolar gyres. It regulates the exchange of water across the shelf break and provides a path for interbasin westward transport. Despite its significance, the ASC remains largely unobserved around most of the Antarctic continent. Here we present direct velocity observations from a 17 month current meter moored array deployed across the continental slope between the 1000 and the 4200 m isobaths, in the southeastern Indian Ocean near 113°E. The observed time-mean flow consists of a surface-intensified jet associated with the Antarctic Slope Front (ASF) and a broader bottom-intensified westward flow that extends out to approximately the 4000 m isobath and is strongest along the upper slope. The time-mean transport of the ASC is -29.2 Sv. Fluctuations in the transport are large, typically exceeding the mean by a factor of 2. They are mainly due to changes in the northward extent of the current over the lower slope. However, seasonal changes in the wind also drive variations in the transport of the ASF and the flow in the upper slope. Both mean and variability are largely barotropic, thus invisible to traditional geostrophic methods.

  6. The Sunburst Arc: Direct Lyman α escape observed in the brightest known lensed galaxy

    Science.gov (United States)

    Rivera-Thorsen, T. E.; Dahle, H.; Gronke, M.; Bayliss, M.; Rigby, J. R.; Simcoe, R.; Bordoloi, R.; Turner, M.; Furesz, G.

    2017-11-01

    We present rest-frame ultraviolet and optical spectroscopy of the brightest lensed galaxy yet discovered, at redshift z = 2.4. The source reveals a characteristic triple-peaked Lyman α profile that has been predicted in various theoretical works, but to our knowledge has not been unambiguously observed previously. The feature is well fit by a superposition of two components: a double-peak profile emerging from substantial radiative transfer, and a narrow, central component resulting from directly escaping Lyman α photons, but it is poorly fit by either component alone. We demonstrate that the feature is unlikely to contain contamination from nearby sources, and that the central peak is unaffected by radiative transfer effects except for very slight absorption. The feature is detected at signal-to-noise ratios exceeding 80 per pixel at line center, and bears strong resemblance to synthetic profiles predicted by numerical models. Based on observations obtained at the Magellan-I (Baade) Telescope at Las Campanas Observatory, Chile.

  7. Direct Observation of Magnetocrystalline Anisotropy Tuning Magnetization Configurations in Uniaxial Magnetic Nanomaterials

    KAUST Repository

    Zhu, Shimeng; Fu, Jiecai; Li, Hongli; Zhu, Liu; Hu, Yang; Xia, Weixing; Zhang, Xixiang; Peng, Yong; Zhang, Junli

    2018-01-01

    Discovering the effect of magnetic anisotropy on the magnetization configurations of magnetic nanomaterials is essential and significant for not only enriching the fundamental knowledge of magnetics but also facilitating the designs of desired magnetic nanostructures for diverse technological applications, such as data storage devices, spintronic devices, and magnetic nanosensors. Herein, we present a direct observation of magnetocrystalline anisotropy tuning magnetization configurations in uniaxial magnetic nanomaterials with hexagonal structure by means of three modeled samples. The magnetic configuration in polycrystalline BaFe12O19 nanoslice is a curling structure, revealing that the effect of magnetocrystalline anisotropy in uniaxial magnetic nanomaterials can be broken by forming an amorphous structure or polycrystalline structure with tiny grains. Both single crystalline BaFe12O19 nanoslice and individual particles of single-particle-chain BaFe12O19 nanowire appear in a single domain state, revealing a dominant role of magnetocrystalline anisotropy in the magnetization configuration of uniaxial magnetic nanomaterials. These observations are further verified by micromagnetic computational simulations.

  8. Direct observation of microtwin formation at crack tips in InP

    International Nuclear Information System (INIS)

    Vanderschaeve, G.; Caillard, D.; Peyrade, J.P.

    1992-01-01

    This paper reports that in brittle materials which contain cracks, stress concentrations arise at crack tips. At low temperatures, when the load is increased, brittle fracture happens for a critical stress intensity factor, which is an intrinsic material property, depending on the loading mode and on the cleavage plane. At higher temperatures dislocations may be emitted at the crack tip: a plastic zone is formed, which releases the stresses and increases the critical load for crack propagation. It is generally accepted that the brittle-to ductile transition is controlled directly or indirectly by dislocation mobility. During the course of an in situ transmission electron microscopy, study of dislocation mobility in the III-V compound InP, we have observed the nucleation at a crack tip and the propagation of partial dislocations of same Burgers vectors, resulting in a microtwinning of the crystal. Such an observation provides information on both the way stress relaxation occurs and the relative mobilities of the partial dislocations in this material. In spite of the importance of twin formation on the quality of the material used as substrate in semiconducting devices, this last point is rather poorly documented

  9. Direct observation of interfacial Au atoms on TiO₂ in three dimensions.

    Science.gov (United States)

    Gao, Wenpei; Sivaramakrishnan, Shankar; Wen, Jianguo; Zuo, Jian-Min

    2015-04-08

    Interfacial atoms, which result from interactions between the metal nanoparticles and support, have a large impact on the physical and chemical properties of nanoparticles. However, they are difficult to observe; the lack of knowledge has been a major obstacle toward unraveling their role in chemical transformations. Here we report conclusive evidence of interfacial Au atoms formed on the rutile (TiO2) (110) surfaces by activation using high-temperature (∼500 °C) annealing in air. Three-dimensional imaging was performed using depth-sectioning enabled by aberration-corrected scanning transmission electron microscopy. Results show that the interface between Au nanocrystals and TiO2 (110) surfaces consists of a single atomic layer with Au atoms embedded inside Ti-O. The number of interfacial Au atoms is estimated from ∼1-8 in an interfacial atomic column. Direct impact of interfacial Au atoms is observed on an enhanced Au-TiO2 interaction and the reduction of surface TiO2; both are critical to Au catalysis.

  10. Direct observation of atomic-level nucleation and growth processes from an ultrathin metallic glass films

    Energy Technology Data Exchange (ETDEWEB)

    Huang, K. Q.; Cao, C. R.; Sun, Y. T.; Li, J.; Bai, H. Y.; Zheng, D. N., E-mail: l.gu@iphy.ac.cn, E-mail: dzheng@iphy.ac.cn, E-mail: whw@iphy.ac.cn; Wang, W. H., E-mail: l.gu@iphy.ac.cn, E-mail: dzheng@iphy.ac.cn, E-mail: whw@iphy.ac.cn [Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Gu, L., E-mail: l.gu@iphy.ac.cn, E-mail: dzheng@iphy.ac.cn, E-mail: whw@iphy.ac.cn [Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Collaborative Innovation Center of Quantum Matter, Beijing 100190 (China)

    2016-01-07

    Till date, there have been no direct atomic-level experimental observations of the earliest stages of the nucleation and growth processes of nanocrystals formed by thermally induced crystallization in ultrathin metallic glasses (MGs). Here, we present a study of the crystallization process in atomically thin and highly stable MG films using double spherical aberration-corrected scanning transmission electron microscopy (Cs-TEM). Taking advantage of the stability of MG films with a slow crystallization process and the atomic-level high resolution of Cs-TEM, we observe the formation of the nucleus precursor of nanocrystals formed by atom aggregation followed by concomitant coalescence and stepwise evolution of the shape of the nanocrystals with a monodispersed and separated bimodal size distribution. Molecular dynamics simulation of the atomic motion in the glass film on a rigid amorphous substrate confirms the stepwise evolution processes of atom aggregation, cluster formation, cluster movement on the substrate, and cluster coalescence into larger crystalline particles. Our results might provide a better fundamental understanding of the nucleation and growth processes of nanocrystals in thin MG films.

  11. Direct Observation of Magnetocrystalline Anisotropy Tuning Magnetization Configurations in Uniaxial Magnetic Nanomaterials

    KAUST Repository

    Zhu, Shimeng

    2018-03-20

    Discovering the effect of magnetic anisotropy on the magnetization configurations of magnetic nanomaterials is essential and significant for not only enriching the fundamental knowledge of magnetics but also facilitating the designs of desired magnetic nanostructures for diverse technological applications, such as data storage devices, spintronic devices, and magnetic nanosensors. Herein, we present a direct observation of magnetocrystalline anisotropy tuning magnetization configurations in uniaxial magnetic nanomaterials with hexagonal structure by means of three modeled samples. The magnetic configuration in polycrystalline BaFe12O19 nanoslice is a curling structure, revealing that the effect of magnetocrystalline anisotropy in uniaxial magnetic nanomaterials can be broken by forming an amorphous structure or polycrystalline structure with tiny grains. Both single crystalline BaFe12O19 nanoslice and individual particles of single-particle-chain BaFe12O19 nanowire appear in a single domain state, revealing a dominant role of magnetocrystalline anisotropy in the magnetization configuration of uniaxial magnetic nanomaterials. These observations are further verified by micromagnetic computational simulations.

  12. Direct observation of shear piezoelectricity in poly-l-lactic acid nanowires

    Directory of Open Access Journals (Sweden)

    Michael Smith

    2017-07-01

    Full Text Available Piezoelectric polymers are capable of interconverting mechanical and electrical energy, and are therefore candidate materials for biomedical applications such as sensors, actuators, and energy harvesters. In particular, nanowires of these materials are attractive as they can be unclamped, flexible and sensitive to small vibrations. Poly-l-lactic acid (PLLA nanowires have been investigated for their use in biological applications, but their piezoelectric properties have never been fully characterised, even though macroscopic films and fibres have been shown to exhibit shear piezoelectricity. This piezoelectric mode is particularly interesting for in vivo applications where shear forces are especially relevant, and is similar to what has been observed in natural materials such as bone and DNA. Here, using piezo-response force microscopy (PFM, we report the first direct observation of shear piezoelectricity in highly crystalline and oriented PLLA nanowires grown by a novel template-wetting method. Our results are validated using finite-element simulations and numerical analysis, which importantly and more generally allow for accurate interpretation of PFM signals in soft nanostructured materials. Our work opens up the possibility for the development of biocompatible and sustainable piezoelectric nanogenerators and sensors based on polymer nanowires.

  13. Direct observations of evolving subglacial drainage beneath the Greenland Ice Sheet.

    Science.gov (United States)

    Andrews, Lauren C; Catania, Ginny A; Hoffman, Matthew J; Gulley, Jason D; Lüthi, Martin P; Ryser, Claudia; Hawley, Robert L; Neumann, Thomas A

    2014-10-02

    Seasonal acceleration of the Greenland Ice Sheet is influenced by the dynamic response of the subglacial hydrologic system to variability in meltwater delivery to the bed via crevasses and moulins (vertical conduits connecting supraglacial water to the bed of the ice sheet). As the melt season progresses, the subglacial hydrologic system drains supraglacial meltwater more efficiently, decreasing basal water pressure and moderating the ice velocity response to surface melting. However, limited direct observations of subglacial water pressure mean that the spatiotemporal evolution of the subglacial hydrologic system remains poorly understood. Here we show that ice velocity is well correlated with moulin hydraulic head but is out of phase with that of nearby (0.3-2 kilometres away) boreholes, indicating that moulins connect to an efficient, channelized component of the subglacial hydrologic system, which exerts the primary control on diurnal and multi-day changes in ice velocity. Our simultaneous measurements of moulin and borehole hydraulic head and ice velocity in the Paakitsoq region of western Greenland show that decreasing trends in ice velocity during the latter part of the melt season cannot be explained by changes in the ability of moulin-connected channels to convey supraglacial melt. Instead, these observations suggest that decreasing late-season ice velocity may be caused by changes in connectivity in unchannelized regions of the subglacial hydrologic system. Understanding this spatiotemporal variability in subglacial pressures is increasingly important because melt-season dynamics affect ice velocity beyond the conclusion of the melt season.

  14. Direct observation of shear piezoelectricity in poly-l-lactic acid nanowires

    Science.gov (United States)

    Smith, Michael; Calahorra, Yonatan; Jing, Qingshen; Kar-Narayan, Sohini

    2017-07-01

    Piezoelectric polymers are capable of interconverting mechanical and electrical energy, and are therefore candidate materials for biomedical applications such as sensors, actuators, and energy harvesters. In particular, nanowires of these materials are attractive as they can be unclamped, flexible and sensitive to small vibrations. Poly-l-lactic acid (PLLA) nanowires have been investigated for their use in biological applications, but their piezoelectric properties have never been fully characterised, even though macroscopic films and fibres have been shown to exhibit shear piezoelectricity. This piezoelectric mode is particularly interesting for in vivo applications where shear forces are especially relevant, and is similar to what has been observed in natural materials such as bone and DNA. Here, using piezo-response force microscopy (PFM), we report the first direct observation of shear piezoelectricity in highly crystalline and oriented PLLA nanowires grown by a novel template-wetting method. Our results are validated using finite-element simulations and numerical analysis, which importantly and more generally allow for accurate interpretation of PFM signals in soft nanostructured materials. Our work opens up the possibility for the development of biocompatible and sustainable piezoelectric nanogenerators and sensors based on polymer nanowires.

  15. Influence of observed diurnal cycles of aerosol optical depth on aerosol direct radiative effect

    Directory of Open Access Journals (Sweden)

    A. Arola

    2013-08-01

    Full Text Available The diurnal variability of aerosol optical depth (AOD can be significant, depending on location and dominant aerosol type. However, these diurnal cycles have rarely been taken into account in measurement-based estimates of aerosol direct radiative forcing (ADRF or aerosol direct radiative effect (ADRE. The objective of our study was to estimate the influence of diurnal aerosol variability at the top of the atmosphere ADRE estimates. By including all the possible AERONET sites, we wanted to assess the influence on global ADRE estimates. While focusing also in more detail on some selected sites of strongest impact, our goal was to also see the possible impact regionally. We calculated ADRE with different assumptions about the daily AOD variability: taking the observed daily AOD cycle into account and assuming diurnally constant AOD. Moreover, we estimated the corresponding differences in ADREs, if the single AOD value for the daily mean was taken from the the Moderate Resolution Imaging Spectroradiometer (MODIS Terra or Aqua overpass times, instead of accounting for the true observed daily variability. The mean impact of diurnal AOD variability on 24 h ADRE estimates, averaged over all AERONET sites, was rather small and it was relatively small even for the cases when AOD was chosen to correspond to the Terra or Aqua overpass time. This was true on average over all AERONET sites, while clearly there can be much stronger impact in individual sites. Examples of some selected sites demonstrated that the strongest observed AOD variability (the strongest morning afternoon contrast does not typically result in a significant impact on 24 h ADRE. In those cases, the morning and afternoon AOD patterns are opposite and thus the impact on 24 h ADRE, when integrated over all solar zenith angles, is reduced. The most significant effect on daily ADRE was induced by AOD cycles with either maximum or minimum AOD close to local noon. In these cases, the impact on

  16. Extreme covariant quantum observables in the case of an Abelian symmetry group and a transitive value space

    International Nuclear Information System (INIS)

    Haapasalo, Erkka Theodor; Pellonpaeae, Juha-Pekka

    2011-01-01

    We represent quantum observables as normalized positive operator valued measures and consider convex sets of observables which are covariant with respect to a unitary representation of a locally compact Abelian symmetry group G. The value space of such observables is a transitive G-space. We characterize the extreme points of covariant observables and also determine the covariant extreme points of the larger set of all quantum observables. The results are applied to position, position difference, and time observables.

  17. Basurto-IGPP. A manual-directed approach of integrative group psychotherapy in psychosis.

    Science.gov (United States)

    Ruiz-Parra, Eduardo; González-Torres, M A; Eguiluz, I; de la Sierra, E; Trojaola, B; Catalán, A

    2010-01-01

    A manual on Integrative Group Psychotherapy for outpatients with schizophrenia and other psychoses (Basurto-PGIP) is presented. The model takes into account group specific therapeutic factors. It integrates influences from other integrative psychotherapeutic models, interpersonal group therapy, group analysis and recent developments in cognitive behavioural therapy for psychotic symptoms. The manual is structured in levels of different complexity that can be applied in a progressive manner. The intervention tries to adapt to patients features, therapists ability and training, and centres resources. It can be applied in two possible settings: a short term closed group and a long term open group. Advantages and disadvantages of the model are described.

  18. Crowd of individuals walking in opposite directions. A toy model to study the segregation of the group into lanes of individuals moving in the same direction

    Science.gov (United States)

    Goldsztein, Guillermo H.

    2017-08-01

    Consider a corridor, street or bridge crowded with pedestrians walking in both directions. The individuals do not walk in a completely straight line. They adjust their path to avoid colliding with incoming pedestrians. As a result of these adjustments, the whole group sometimes end up split into lanes of individuals moving in the same direction. While this formation of lanes facilitates the flow and benefits the whole group, it is believed that results from the actions of the individuals acting only on their behalf, without considering others. This phenomenon is an example of self-organization. We analyze a simple model. We assume that individuals move around a two-lane circular track. All of them at the same speed. Half of them in one direction and the rest in the opposite direction. Each time two individuals collide, one of them moves to the other lane. The individual changing lanes is selected randomly. The system self-organizes. Eventually each lane is occupied with individuals moving in only one direction. We show that the time required for the system to self-organize is bounded by a linear function on the number of individuals. This toy model provides an example where global self-organization occurs even though each member of the group acts without considering the rest.

  19. INFRARED AND RADIO OBSERVATIONS OF A SMALL GROUP OF PROTOSTELLAR OBJECTS IN THE MOLECULAR CORE, L1251-C

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jungha; Lee, Jeong-Eun [School of Space Research, Kyung Hee University, Yongin-Si, Gyeonggi-Do 446-701 (Korea, Republic of); Choi, Minho; Kang, Miju [Korea Astronomy and Space Science Institute, 776 Daedeokdaero, Yuseong, Daejeon 305-348 (Korea, Republic of); Bourke, Tyler L. [Square Kilometre Array Organisation, Jodrell Bank Observatory, Lower Withington, Cheshire SK11 9DL (United Kingdom); II, Neal J. Evans [Department of Astronomy, University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Francesco, James Di [National Research Council Canada, Herzberg Institute of Astrophysics, Victoria, BC (Canada); Cieza, Lucas A. [Universidad Diego Portales, Facultad de Ingeniera, Av. Ejército 441, Santiago (Chile); Dunham, Michael M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2015-05-15

    We present a multi-wavelength observational study of a low-mass star-forming region, L1251-C, with observational results at wavelengths from the near-infrared to the millimeter. Spitzer Space Telescope observations confirmed that IRAS 22343+7501 is a small group of protostellar objects. The extended emission in the east–west direction with its intensity peak at the center of L1251A has been detected at 350 and 850 μm with the Caltech Submillimeter Observatory and James Clerk Maxwell telescopes, tracing dense envelope material around L1251A. The single-dish data from the Korean VLBI Network and TRAO telescopes show inconsistencies between the intensity peaks of several molecular emission lines and that of the continuum emission, suggesting complex distributions of molecular abundances around L1251A. The Submillimeter Array interferometer data, however, show intensity peaks of CO 2–1 and {sup 13}CO 2–1 located at the position of IRS 1, which is both the brightest source in the Infrared Array Camera image and the weakest source in the 1.3 mm dust-continuum map. IRS 1 is the strongest candidate for the driving source of the newly detected compact CO 2–1 outflow. Over the entire region (14′ × 14′) of L125l-C, 3 Class I and 16 Class II sources have been detected, including three young stellar objects (YSOs) in L1251A. A comparison between the average projected distance among the 19 YSOs in L1251-C and that among the 3 YSOs in L1251A suggests that L1251-C is an example of low-mass cluster formation where protostellar objects form in a small group.

  20. Comparing Treatment and Control Groups on Multiple Outcomes: Robust Procedures for Testing a Directional Alternative Hypothesis

    Science.gov (United States)

    Lix, Lisa M.; Deering, Kathleen N.; Fouladi, Rachel T.; Manivong, Phongsack

    2009-01-01

    This study considers the problem of testing the difference between treatment and control groups on m [greater than or equal to] 2 measures when it is assumed a priori that the treatment group will perform better than the control group on all measures. Two procedures are investigated that do not rest on the assumptions of covariance homogeneity or…

  1. First direct observations linking confined supercritical turbidity currents to their depositional architecture and facies characteristics

    Science.gov (United States)

    Hage, S.; Cartigny, M.; Hughes Clarke, J. E.; Clare, M. A.; Sumner, E.; Hubbard, S. M.; Talling, P.; Lintern, G.; Stacey, C.; Vardy, M. E.; Hunt, J.; Vendettuoli, D.; Yokokawa, M.; Hizzett, J. L.; Vellinga, A. J.; Azpiroz, M.

    2017-12-01

    Turbidity currents transfer globally significant amounts of sediment via submarine channels from the continental margin to deep submarine fans. Submarine channel inception is thought to result from erosive, supercritical turbidity currents that are common in proximal settings of the marine realm. Recent monitoring of submarine processes have provided the first measurements of supercritical turbidity currents (Hughes Clarke, 2016), demonstrating that they drive the upstream migration of crescentic bedforms in confined submarine channels. Although upstream-migrating bedforms are common in confined channels across the world's oceans, there is considerable debate over the type of deposits that they produce. It is important to understand what types of deposit record these supercritical bedforms to potentially identify them from geological archives. For the first time, we combine direct measurements from supercritical field-scale turbidity currents with the facies and depositional architecture resulting from such flows. We show how the subsurface architecture evolves in a highly active channel at Squamish submarine delta, British Columbia, Canada. Repeated upstream migration of bedforms is found to create two main deposit geometries. First, regular back-stepping beds result from flow deceleration on the slightly-inclined sides of the bedforms. Second, lens-shaped scour fills composed of massive deposits result from erosion of the back-stepping beds by subsequent turbidity currents. We relate our findings to a range of ancient outcrop studies to demonstrate that supercritical flows are common in proximal settings through the geological record. This study provides the first direct observation-based model to identify confined supercritical turbidity currents and their associated upslope-migrating bedforms in the sedimentary record. This is important for correctly identifying the proximal sites of ancient submarine channels that served as past conduits for globally

  2. Mapping Direct Observations From Objective Structured Clinical Examinations to the Milestones Across Specialties.

    Science.gov (United States)

    Baker-Genaw, Kimberly; Kokas, Maria S; Ahsan, Syed F; Darnley-Fisch, Deborah; Drake, Sean; Goyal, Nikhil; Inamdar, Kedar; Moutzouros, Vasilios; Prabhakar, Deepak; Rolland, Laurie; Sangha, Roopina; Shreve, Maria; Woodward, Ann

    2016-07-01

    Little is known about residents' performance on the milestones at the institutional level. Our institution formed a work group to explore this using an institutional-level curriculum and residents' evaluation of the milestones. We assessed whether beginner-level milestones for interpersonal and communication skills (ICS) related to observable behaviors in ICS-focused objective structured clinical examinations (OSCEs) for postgraduate year (PGY) 1 residents across specialties. The work group compared ICS subcompetencies across 12 programs to identify common beginner-level physician-patient communication milestones. The selected ICS milestone sets were compared for common language with the ICS-OSCE assessment tool-the Kalamazoo Essential Elements of Communication Checklist-Adapted (KEECC-A). To assess whether OSCE scores related to ICS milestone scores, all PGY-1 residents from programs that were part of Next Accreditation System Phase 1 were identified; their OSCE scores from July 2013 to June 2014 and ICS subcompetency scores from December 2014 were compared. The milestones for 10 specialties and the transitional year had at least 1 ICS subcompetency that related to physician-patient communication. The language of the ICS beginner-level milestones appears similar to behaviors outlined in the KEECC-A. All 60 residents with complete data received at least a beginner-level ICS subcompetency score and at least a satisfactory score on all 3 OSCEs. The ICS-OSCE scores for PGY-1 residents appear to relate to beginner-level milestones for physician-patient communication across multiple specialties.

  3. Infants' social withdrawal symptoms assessed with a direct infant observation method in primary health care.

    Science.gov (United States)

    Puura, Kaija; Mäntymaa, Mirjami; Luoma, Ilona; Kaukonen, Pälvi; Guedeney, Antoine; Salmelin, Raili; Tamminen, Tuula

    2010-12-01

    Distressed infants may withdraw from social interaction, but recognising infants' social withdrawal is difficult. The aims of the study were to see whether an infant observation method can be reliably used by front line workers, and to examine the prevalence of infants' social withdrawal symptoms. A random sample of 363 families with four, eight or 18-month-old infants participated in the study. The infants were examined by general practitioners (GPs) in well-baby clinics with the Alarm Distress BaBy Scale (ADBB), an observation method developed for clinical settings. A score of five or more on the ADBB Scale in two subsequent assessments at a two-week interval was regarded as a sign of clinically significant infant social withdrawal. Kappas were calculated for the GPs' correct rating of withdrawn/not withdrawn against a set of videotapes rated by developer of the method, Professor Guedeney and his research group. The kappas for their ratings ranged from 0.5 to 1. The frequency of infants scoring above the cut off in two subsequent assessments was 3%. The ADBB Scale is a promising method for detecting infant social withdrawal in front line services. Three percents of infants were showing sustained social withdrawal as a sign of distress in this normal population sample. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. Modelled radiative forcing of the direct aerosol effect with multi-observation evaluation

    Directory of Open Access Journals (Sweden)

    G. Myhre

    2009-02-01

    Full Text Available A high-resolution global aerosol model (Oslo CTM2 driven by meteorological data and allowing a comparison with a variety of aerosol observations is used to simulate radiative forcing (RF of the direct aerosol effect. The model simulates all main aerosol components, including several secondary components such as nitrate and secondary organic carbon. The model reproduces the main chemical composition and size features observed during large aerosol campaigns. Although the chemical composition compares best with ground-based measurement over land for modelled sulphate, no systematic differences are found for other compounds. The modelled aerosol optical depth (AOD is compared to remote sensed data from AERONET ground and MODIS and MISR satellite retrievals. To gain confidence in the aerosol modelling, we have tested its ability to reproduce daily variability in the aerosol content, and this is performing well in many regions; however, we also identified some locations where model improvements are needed. The annual mean regional pattern of AOD from the aerosol model is broadly similar to the AERONET and the satellite retrievals (mostly within 10–20%. We notice a significant improvement from MODIS Collection 4 to Collection 5 compared to AERONET data. Satellite derived estimates of aerosol radiative effect over ocean for clear sky conditions differs significantly on regional scales (almost up to a factor two, but also in the global mean. The Oslo CTM2 has an aerosol radiative effect close to the mean of the satellite derived estimates. We derive a radiative forcing (RF of the direct aerosol effect of −0.35 Wm−2 in our base case. Implementation of a simple approach to consider internal black carbon (BC mixture results in a total RF of −0.28 Wm−2. Our results highlight the importance of carbonaceous particles, producing stronger individual RF than considered in the recent IPCC estimate; however, net RF is less different

  5. Directions for new developments on statistical design and analysis of small population group trials.

    Science.gov (United States)

    Hilgers, Ralf-Dieter; Roes, Kit; Stallard, Nigel

    2016-06-14

    Most statistical design and analysis methods for clinical trials have been developed and evaluated where at least several hundreds of patients could be recruited. These methods may not be suitable to evaluate therapies if the sample size is unavoidably small, which is usually termed by small populations. The specific sample size cut off, where the standard methods fail, needs to be investigated. In this paper, the authors present their view on new developments for design and analysis of clinical trials in small population groups, where conventional statistical methods may be inappropriate, e.g., because of lack of power or poor adherence to asymptotic approximations due to sample size restrictions. Following the EMA/CHMP guideline on clinical trials in small populations, we consider directions for new developments in the area of statistical methodology for design and analysis of small population clinical trials. We relate the findings to the research activities of three projects, Asterix, IDeAl, and InSPiRe, which have received funding since 2013 within the FP7-HEALTH-2013-INNOVATION-1 framework of the EU. As not all aspects of the wide research area of small population clinical trials can be addressed, we focus on areas where we feel advances are needed and feasible. The general framework of the EMA/CHMP guideline on small population clinical trials stimulates a number of research areas. These serve as the basis for the three projects, Asterix, IDeAl, and InSPiRe, which use various approaches to develop new statistical methodology for design and analysis of small population clinical trials. Small population clinical trials refer to trials with a limited number of patients. Small populations may result form rare diseases or specific subtypes of more common diseases. New statistical methodology needs to be tailored to these specific situations. The main results from the three projects will constitute a useful toolbox for improved design and analysis of small

  6. Direct Power Control for Three-Phase Two-Level Voltage-Source Rectifiers Based on Extended-State Observation

    DEFF Research Database (Denmark)

    Song, Zhanfeng; Tian, Yanjun; Yan, Zhuo

    2016-01-01

    This paper proposed a direct power control strategy for three-phase two-level voltage-source rectifiers based on extended-state observation. Active and reactive powers are directly regulated in the stationary reference frame. Similar to the family of predictive controllers whose inherent characte......This paper proposed a direct power control strategy for three-phase two-level voltage-source rectifiers based on extended-state observation. Active and reactive powers are directly regulated in the stationary reference frame. Similar to the family of predictive controllers whose inherent...

  7. Effect of formative evaluation using direct observation of procedural skills in assessment of postgraduate students of obstetrics and gynecology: Prospective study.

    Science.gov (United States)

    Kumar, Naina; Singh, Namit Kant; Rudra, Samar; Pathak, Swanand

    2017-01-01

    Direct Observation of Procedural Skills (DOPS) is a way of evaluating procedural skills through observation in the workplace. The purpose of this study was to assess the role of DOPS in teaching and assessment of postgraduate students and to know the effect of repeated DOPS on improvement of the skills and confidence of the students. In both phases, significant difference was observed between the two groups on first DOPS comparison (1st phase: p=0.000; 2nd phase: p=0.002), with simulation group performing better. Comparison of sixth DOPS in the two groups revealed no difference in both phases, but significant difference on first and sixth DOPS comparison in each group (p=0.000). Repeated DOPS results in improved skills and confidence of students in managing real life obstetric emergencies irrespective of the teaching modality. Repeated DOPS results in improved skills and confidence of students in managing real life obstetric emergencies irrespective of the teaching modality.

  8. Direct observation of the myosin Va recovery stroke that contributes to unidirectional stepping along actin.

    Directory of Open Access Journals (Sweden)

    Katsuyuki Shiroguchi

    2011-04-01

    Full Text Available Myosins are ATP-driven linear molecular motors that work as cellular force generators, transporters, and force sensors. These functions are driven by large-scale nucleotide-dependent conformational changes, termed "strokes"; the "power stroke" is the force-generating swinging of the myosin light chain-binding "neck" domain relative to the motor domain "head" while bound to actin; the "recovery stroke" is the necessary initial motion that primes, or "cocks," myosin while detached from actin. Myosin Va is a processive dimer that steps unidirectionally along actin following a "hand over hand" mechanism in which the trailing head detaches and steps forward ∼72 nm. Despite large rotational Brownian motion of the detached head about a free joint adjoining the two necks, unidirectional stepping is achieved, in part by the power stroke of the attached head that moves the joint forward. However, the power stroke alone cannot fully account for preferential forward site binding since the orientation and angle stability of the detached head, which is determined by the properties of the recovery stroke, dictate actin binding site accessibility. Here, we directly observe the recovery stroke dynamics and fluctuations of myosin Va using a novel, transient caged ATP-controlling system that maintains constant ATP levels through stepwise UV-pulse sequences of varying intensity. We immobilized the neck of monomeric myosin Va on a surface and observed real time motions of bead(s attached site-specifically to the head. ATP induces a transient swing of the neck to the post-recovery stroke conformation, where it remains for ∼40 s, until ATP hydrolysis products are released. Angle distributions indicate that the post-recovery stroke conformation is stabilized by ≥ 5 k(BT of energy. The high kinetic and energetic stability of the post-recovery stroke conformation favors preferential binding of the detached head to a forward site 72 nm away. Thus, the recovery

  9. Direct observation of a single proton in a Penning trap. Towards a direct measurement of the proton g-factor

    Energy Technology Data Exchange (ETDEWEB)

    Kreim, Susanne Waltraud

    2009-08-25

    This PhD thesis presents experiments performed on a single proton stored in a Penning trap. The eigenmotion of an isolated, free proton could be detected electronically via a coupling to a resonance circuit. This represents a non-destructive measurement, i.e. the particle is not lost during the measurement. The free cyclotron frequency emerging from the measured eigenfrequencies is one of the two frequencies required for the determination of the magnetic moment. This enables a direct determination of the g-factor contrary to already existing works. Design, developing, and commissioning of the experimental setup have been accomplished within the scope of this work leading to a measuring accuracy of 10{sup -7}. The technical challenges for the determination of the second frequency (the Larmor frequency) arising from the smallness of the magnetic moment were mastered. Since the spin state required for this measurement is an internal degree of freedom, it can only be accessed through a coupling of the magnetic moment to the eigenmotion. A novel, hybrid penning trap is presented in this work, which imprints the spin information onto the eigenmotion, thus, realizing a quantum jump spectrometer. Therewith, the frequency shift of the two spin states resulting from the magnetic coupling reaches for the first time an electronically detectable range. (orig.)

  10. Direct observation of a single proton in a Penning trap. Towards a direct measurement of the proton g-factor

    International Nuclear Information System (INIS)

    Kreim, Susanne Waltraud

    2009-01-01

    This PhD thesis presents experiments performed on a single proton stored in a Penning trap. The eigenmotion of an isolated, free proton could be detected electronically via a coupling to a resonance circuit. This represents a non-destructive measurement, i.e. the particle is not lost during the measurement. The free cyclotron frequency emerging from the measured eigenfrequencies is one of the two frequencies required for the determination of the magnetic moment. This enables a direct determination of the g-factor contrary to already existing works. Design, developing, and commissioning of the experimental setup have been accomplished within the scope of this work leading to a measuring accuracy of 10 -7 . The technical challenges for the determination of the second frequency (the Larmor frequency) arising from the smallness of the magnetic moment were mastered. Since the spin state required for this measurement is an internal degree of freedom, it can only be accessed through a coupling of the magnetic moment to the eigenmotion. A novel, hybrid penning trap is presented in this work, which imprints the spin information onto the eigenmotion, thus, realizing a quantum jump spectrometer. Therewith, the frequency shift of the two spin states resulting from the magnetic coupling reaches for the first time an electronically detectable range. (orig.)

  11. SENSITIVE 21 cm OBSERVATIONS OF NEUTRAL HYDROGEN IN THE LOCAL GROUP NEAR M31

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, Spencer A.; Pisano, D. J. [Dept. of Physics and Astronomy, West Virginia University, Morgantown, WV 26506 (United States); Lockman, Felix J., E-mail: swolfe4@mix.wvu.edu, E-mail: DJPisano@mail.wvu.edu, E-mail: jlockman@nrao.edu [National Radio Astronomy Observatory, Green Bank, WV 24944 (United States)

    2016-01-10

    Very sensitive 21 cm H i measurements have been made at several locations around the Local Group galaxy M31 using the Green Bank Telescope at an angular resolution of 9.′1, with a 5σ detection level of N{sub H} {sub i} = 3.9 × 10{sup 17} cm{sup −2} for a 30 km s{sup −1} line. Most of the H i in a 12 square-degree area almost equidistant between M31 and M33 is contained in nine discrete clouds that have a typical size of a few kpc and a H i mass of 10{sup 5}M{sub ⊙}. Their velocities in the Local Group Standard of Rest lie between −100 and +40 km s{sup −1}, comparable to the systemic velocities of M31 and M33. The clouds appear to be isolated kinematically and spatially from each other. The total H i mass of all nine clouds is 1.4 × 10{sup 6}M{sub ⊙} for an adopted distance of 800 kpc, with perhaps another 0.2 × 10{sup 6}M{sub ⊙} in smaller clouds or more diffuse emission. The H i mass of each cloud is typically three orders of magnitude less than the dynamical (virial) mass needed to bind the cloud gravitationally. Although they have the size and H i mass of dwarf galaxies, the clouds are unlikely to be part of the satellite system of the Local Group, as they lack stars. To the north of M31, sensitive H i measurements on a coarse grid find emission that may be associated with an extension of the M31 high-velocity cloud (HVC) population to projected distances of ∼100 kpc. An extension of the M31 HVC population at a similar distance to the southeast, toward M33, is not observed.

  12. Changing emergence of Shigella sero-groups in Bangladesh: observation from four different diarrheal disease hospitals.

    Directory of Open Access Journals (Sweden)

    Sumon Kumar Das

    Full Text Available BACKGROUND: Shigellosis continues to be a public health challenge for developing countries, including Bangladesh. The aim of the study is to demonstrate recent changes in Shigella sero-groups and their geographical diversity. METHODS: Data were extracted from data archive of four diarrheal disease surveillance systems. A 2% sub sample from urban Dhaka Hospital (2008-2011; n = 10,650, and 10% from urban Mirpur Treatment Centre (2009-2011; n = 3,585, were enrolled systematically; whereas, all patients coming from the Health and Demographic Surveillance System area in rural Matlab (2008-2011; n = 6,399 and rural Mirzapur (2010-2011; n = 2,812 were included irrespective of age, sex, and disease severity. A fresh stool specimen was collected for identification of Shigella spp. Of them, 315 (3% were positive for Shigella in Dhaka, 490 (8% from Matlab, 109 (3% from Mirpur and 369 (13% from Mirzapur and considered as analyzable sample size. RESULTS: Among all Shigella isolates regardless of age, significant decreases in percentage of S. flexneri over time was observed in Mirpur (55→29%; p value of χ(2-for trend = 0.019 and Mirzapur (59→47%; p = 0.025. A non-significant decrease was also seen in Dhaka (58→48%, while in Matlab there was a non-significant increase (73→81%. Similar patterns were observed among under-5 children at all sites. Emergence of S. sonnei was found in Dhaka (8→25%; p<0.001 and Mirpur (10→33%; p = 0.015, whereas it decreased in Mirzapur (32→23%; p = 0.056. The emergence of S. boydii was seen in all ages in Mirzapur [(3→28%; p<0.001; (3→27%; p<0.001]. On the other hand, we saw non-significant percent reductions in S. boydii in Dhaka [overall (25→16%; under-5 (16→9%]. Decreasing rates of Shigella dysenteriae were observed in Matlab, Mirpur and Mirzapur; whereas, in Dhaka it remained unchanged. CONCLUSION AND SIGNIFICANCE: Emergence of S. sonnei and S. boydii as important infectious

  13. Changing Emergence of Shigella Sero-Groups in Bangladesh: Observation from Four Different Diarrheal Disease Hospitals

    Science.gov (United States)

    Das, Sumon Kumar; Ahmed, Shahnawaz; Ferdous, Farzana; Farzana, Fahmida Dil; Chisti, Mohammod Jobayer; Leung, Daniel T.; Malek, Mohammad Abdul; Talukder, Kaisar Ali; Bardhan, Pradip Kumar; Salam, Mohammed Abdus; Faruque, Abu Syed Golam; Raqib, Rubhana

    2013-01-01

    Background Shigellosis continues to be a public health challenge for developing countries, including Bangladesh. The aim of the study is to demonstrate recent changes in Shigella sero-groups and their geographical diversity. Methods Data were extracted from data archive of four diarrheal disease surveillance systems. A 2% sub sample from urban Dhaka Hospital (2008–2011; n = 10,650), and 10% from urban Mirpur Treatment Centre (2009–2011; n = 3,585), were enrolled systematically; whereas, all patients coming from the Health and Demographic Surveillance System area in rural Matlab (2008–2011; n = 6,399) and rural Mirzapur (2010–2011; n = 2,812) were included irrespective of age, sex, and disease severity. A fresh stool specimen was collected for identification of Shigella spp. Of them, 315 (3%) were positive for Shigella in Dhaka, 490 (8%) from Matlab, 109 (3%) from Mirpur and 369 (13%) from Mirzapur and considered as analyzable sample size. Results Among all Shigella isolates regardless of age, significant decreases in percentage of S. flexneri over time was observed in Mirpur (55→29%; p value of χ2-for trend = 0.019) and Mirzapur (59→47%; p = 0.025). A non-significant decrease was also seen in Dhaka (58→48%), while in Matlab there was a non-significant increase (73→81%). Similar patterns were observed among under-5 children at all sites. Emergence of S. sonnei was found in Dhaka (8→25%; pp = 0.015), whereas it decreased in Mirzapur (32→23%; p = 0.056). The emergence of S. boydii was seen in all ages in Mirzapur [(3→28%; pp<0.001)]. On the other hand, we saw non-significant percent reductions in S. boydii in Dhaka [overall (25→16%); under-5 (16→9%)]. Decreasing rates of Shigella dysenteriae were observed in Matlab, Mirpur and Mirzapur; whereas, in Dhaka it remained unchanged. Conclusion and Significance Emergence of S. sonnei and S. boydii as important infectious diarrhea etiologies and variations in

  14. Social worker assessment of bad news delivery by emergency medicine residents: a novel direct-observation milestone assessment.

    Science.gov (United States)

    Min, Alice Ann; Spear-Ellinwood, Karen; Berman, Melissa; Nisson, Peyton; Rhodes, Suzanne Michelle

    2016-09-01

    The skill of delivering bad news is difficult to teach and evaluate. Residents may practice in simulated settings; however, this may not translate to confidence or competence during real experiences. We investigated the acceptability and feasibility of social workers as evaluators of residents' delivery of bad news during patient encounters, and assessed the attitudes of both groups regarding this process. From August 2013 to June 2014, emergency medicine residents completed self-assessments after delivering bad news. Social workers completed evaluations after observing these conversations. The Assessment tools were designed by modifying the global Breaking Bad News Assessment Scale. Residents and social workers completed post-study surveys. 37 evaluations were received, 20 completed by social workers and 17 resident self-evaluations. Social workers reported discussing plans with residents prior to conversations 90 % of the time (18/20, 95 % CI 64.5, 97.8). Social workers who had previously observed the resident delivering bad news reported that the resident was more skilled on subsequent encounters 90 % of the time (95 % CI 42.2, 99). Both social workers and residents felt that prior training or experience was important. First-year residents valued advice from social workers less than advice from attending physicians, whereas more experienced residents perceived advice from social workers to be equivalent with that of attending physicians (40 versus 2.9 %, p = 0.002). Social worker assessment of residents' abilities to deliver bad news is feasible and acceptable to both groups. This formalized self-assessment and evaluation process highlights the importance of social workers' involvement in delivery of bad news, and the teaching of this skill. This method may also be used as direct-observation for resident milestone assessment.

  15. Testing a direction-dependent primordial power spectrum with observations of the cosmic microwave background

    International Nuclear Information System (INIS)

    Ma Yinzhe; Efstathiou, George; Challinor, Anthony

    2011-01-01

    Statistical isotropy is often assumed in cosmology and should be tested rigorously against observational data. We construct simple quadratic estimators to reconstruct asymmetry in the primordial power spectrum from CMB temperature and polarization data and verify their accuracy using simulations with quadrupole power asymmetry. We show that the Planck mission, with its millions of signal-dominated modes of the temperature anisotropy, should be able to constrain the amplitude of any spherical multipole of a scale-invariant quadrupole asymmetry at the 0.01 level (2σ). Almost independent constraints can be obtained from polarization at the 0.03 level after four full-sky surveys, providing an important consistency test. If the amplitude of the asymmetry is large enough, constraining its scale dependence should become possible. In scale-free quadrupole models with 1% asymmetry, consistent with the current limits from WMAP temperature data (after correction for beam asymmetries), Planck should constrain the spectral index q of power-law departures from asymmetry to Δq=0.3. Finally, we show how to constrain models with axisymmetry in the same framework. For scale-free quadrupole models, Planck should constrain the direction of the asymmetry to a 1σ accuracy of about 2 degrees using one year of temperature data.

  16. Direct observation of lithium polysulfides in lithium-sulfur batteries using operando X-ray diffraction

    Science.gov (United States)

    Conder, Joanna; Bouchet, Renaud; Trabesinger, Sigita; Marino, Cyril; Gubler, Lorenz; Villevieille, Claire

    2017-06-01

    In the on going quest towards lithium-battery chemistries beyond the lithium-ion technology, the lithium-sulfur system is emerging as one of the most promising candidates. The major outstanding challenge on the route to commercialization is controlling the so-called polysulfide shuttle, which is responsible for the poor cycling efficiency of the current generation of lithium-sulfur batteries. However, the mechanistic understanding of the reactions underlying the polysulfide shuttle is still incomplete. Here we report the direct observation of lithium polysulfides in a lithium-sulfur cell during operation by means of operando X-ray diffraction. We identify signatures of polysulfides adsorbed on the surface of a glass-fibre separator and monitor their evolution during cycling. Furthermore, we demonstrate that the adsorption of the polysulfides onto SiO2 can be harnessed for buffering the polysulfide redox shuttle. The use of fumed silica as an electrolyte additive therefore significantly improves the specific charge and Coulombic efficiency of lithium-sulfur batteries.

  17. Does direct observation of procedural skills reflect trainee's progress in otolaryngology?

    Science.gov (United States)

    Awad, Z; Hayden, L; Muthuswamy, K; Ziprin, P; Darzi, A; Tolley, N S

    2014-06-01

    UK surgical trainees are required to undertake work-based assessments each year in order to progress in their training. Direct Observation of Procedural Skills (DOPS) is one of these assessments. We aim to investigate the validity of DOPS in assessing otolaryngology trainees at all levels. A retrospective search of the portfolios of all otolaryngology trainees in North Thames was carried out to identify otolaryngology-specific DOPS. A score (Cs) was calculated for each DOPS based on the percentage of satisfactorily-rated items. The overall performance rating (Ps) was analysed as a separate variable and compared with Cs. The Ps and Cs results were then compared across trainee grades and levels within each grade: Core trainees (CT1-CT2) and specialty trainees (ST3-ST8). Seven hundred and sixty-seven otolaryngology DOPS were completed between August 2008 and September 2013. The tool was found to be reliable and internally consistent. Trainees in ST grade had higher Cs and Ps scores than CT grade (P Otolaryngology DOPS is a useful tool in assessing otolaryngology trainees especially from CT1-ST3 level. DOPS can also differentiate between junior and senior trainees. However, it was not able to demonstrate progress at levels above ST3, most likely due to the simplicity of the procedures which trainees tend to master in the first few years of training. © 2014 John Wiley & Sons Ltd.

  18. Direct observations of ice seasonality reveal changes in climate over the past 320–570 years

    Science.gov (United States)

    Sharma, Sapna; Magnuson, John J.; Batt, Ryan D.; Winslow, Luke; Korhonen, Johanna; Yasuyuki Aono,

    2016-01-01

    Lake and river ice seasonality (dates of ice freeze and breakup) responds sensitively to climatic change and variability. We analyzed climate-related changes using direct human observations of ice freeze dates (1443–2014) for Lake Suwa, Japan, and of ice breakup dates (1693–2013) for Torne River, Finland. We found a rich array of changes in ice seasonality of two inland waters from geographically distant regions: namely a shift towards later ice formation for Suwa and earlier spring melt for Torne, increasing frequencies of years with warm extremes, changing inter-annual variability, waning of dominant inter-decadal quasi-periodic dynamics, and stronger correlations of ice seasonality with atmospheric CO2 concentration and air temperature after the start of the Industrial Revolution. Although local factors, including human population growth, land use change, and water management influence Suwa and Torne, the general patterns of ice seasonality are similar for both systems, suggesting that global processes including climate change and variability are driving the long-term changes in ice seasonality.

  19. Observations of Group Care Worker-Child Interaction in Residential Youth Care: Pedagogical Interventions and Child Behavior

    NARCIS (Netherlands)

    Bastiaanssen, I.L.W.; Delsing, M.J.M.H.; Geijsen, L.; Kroes, G.; Veerman, J.W.; Engels, R.C.M.E.

    2014-01-01

    The work of group care workers in residential youth care is often described as professional parenting. Pedagogical interventions of group care workers influence the quality of care for looked-after children. The aim of the current study was to observe the pedagogical interventions of group care

  20. Observations of Group Care Worker-Child Interaction in Residential Youth Care: Pedagogical Interventions and Child Behavior

    Science.gov (United States)

    Bastiaanssen, Inge L. W.; Delsing, Marc J. M. H.; Geijsen, Luuk; Kroes, Gert; Veerman, Jan W.; Engels, Rutger C. M. E.

    2014-01-01

    Background: The work of group care workers in residential youth care is often described as professional parenting. Pedagogical interventions of group care workers influence the quality of care for looked-after children. Objective: The aim of the current study was to observe the pedagogical interventions of group care workers within residential…

  1. Subordinate females in the cooperatively breeding Seychelles warbler obtain direct benefits by joining unrelated groups.

    Science.gov (United States)

    Groenewoud, Frank; Kingma, Sjouke A; Hammers, Martijn; Dugdale, Hannah L; Burke, Terry; Richardson, David S; Komdeur, Jan

    2018-05-11

    1.In many cooperatively breeding animals, a combination of ecological constraints and benefits of philopatry favours offspring taking a subordinate position on the natal territory instead of dispersing to breed independently. However, in many species individuals disperse to a subordinate position in a non-natal group ("subordinate between-group" dispersal), despite losing the kin-selected and nepotistic benefits of remaining in the natal group. It is unclear which social, genetic and ecological factors drive between-group dispersal. 2.We aim to elucidate the adaptive significance of subordinate between-group dispersal by examining which factors promote such dispersal, whether subordinates gain improved ecological and social conditions by joining a non-natal group, and whether between-group dispersal results in increased lifetime reproductive success and survival. 3.Using a long-term dataset on the cooperatively-breeding Seychelles warbler (Acrocephalus sechellensis), we investigated 4.how a suite of proximate factors (food availability, group composition, age and sex of focal individuals, population density) promote subordinate between-group dispersal by comparing such dispersers with subordinates that dispersed to a dominant position or became floaters. We then analysed whether subordinates that moved to a dominant or non-natal subordinate position, or became floaters, gained improved conditions relative to the natal territory, and compared fitness components between the three dispersal strategies. 5.We show that individuals that joined another group as non-natal subordinates were mainly female and that, similar to floating, between-group dispersal was associated with social and demographic factors that constrained dispersal to an independent breeding position. Between-group dispersal was not driven by improved ecological or social conditions in the new territory and did not result in higher survival. Instead, between-group dispersing females often became co

  2. Tools for the direct observation and assessment of psychomotor skills in medical trainees: a systematic review.

    Science.gov (United States)

    Jelovsek, J Eric; Kow, Nathan; Diwadkar, Gouri B

    2013-07-01

    The Accreditation Council for Graduate Medical Education (ACGME) Milestone Project mandates programmes to assess the attainment of training outcomes, including the psychomotor (surgical or procedural) skills of medical trainees. The objectives of this study were to determine which tools exist to directly assess psychomotor skills in medical trainees on live patients and to identify the data indicating their psychometric and edumetric properties. An electronic search was conducted for papers published from January 1948 to May 2011 using the PubMed, Education Resource Information Center (ERIC), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Web of Science electronic databases and the review of references in article bibliographies. A study was included if it described a tool or instrument designed for the direct observation of psychomotor skills in patient care settings by supervisors. Studies were excluded if they referred to tools that assessed only clinical or non-technical skills, involved non-medical health professionals, or assessed skills performed on a simulator. Overall, 4114 citations were screened, 168 (4.1%) articles were reviewed for eligibility and 51 (1.2%) manuscripts were identified as meeting the study inclusion criteria. Three authors abstracted and reviewed studies using a standardised form for the presence of key psychometric and edumetric elements as per ACGME and American Psychological Association (APA) recommendations, and also assigned an overall grade based on the ACGME Committee on Educational Outcome Assessment grading system. A total of 30 tools were identified. Construct validity based on associations between scores and training level was identified in 24 tools, internal consistency in 14, test-retest reliability in five and inter-rater reliability in 20. The modification of attitudes, knowledge or skills was reported using five tools. The seven-item Global Rating Scale and the Procedure-Based Assessment received an

  3. Direct observations of atmosphere - sea ice - ocean interactions during Arctic winter and spring storms

    Science.gov (United States)

    Graham, R. M.; Itkin, P.; Granskog, M. A.; Assmy, P.; Cohen, L.; Duarte, P.; Doble, M. J.; Fransson, A.; Fer, I.; Fernandez Mendez, M.; Frey, M. M.; Gerland, S.; Haapala, J. J.; Hudson, S. R.; Liston, G. E.; Merkouriadi, I.; Meyer, A.; Muilwijk, M.; Peterson, A.; Provost, C.; Randelhoff, A.; Rösel, A.; Spreen, G.; Steen, H.; Smedsrud, L. H.; Sundfjord, A.

    2017-12-01

    To study the thinner and younger sea ice that now dominates the Arctic the Norwegian Young Sea ICE expedition (N-ICE2015) was launched in the ice-covered region north of Svalbard, from January to June 2015. During this time, eight local and remote storms affected the region and rare direct observations of the atmosphere, snow, ice and ocean were conducted. Six of these winter storms passed directly over the expedition and resulted in air temperatures rising from below -30oC to near 0oC, followed by abrupt cooling. Substantial snowfall prior to the campaign had already formed a snow pack of approximately 50 cm, to which the February storms contributed an additional 6 cm. The deep snow layer effectively isolated the ice cover and prevented bottom ice growth resulting in low brine fluxes. Peak wind speeds during winter storms exceeded 20 m/s, causing strong snow re-distribution, release of sea salt aerosol and sea ice deformation. The heavy snow load caused widespread negative freeboard; during sea ice deformation events, level ice floes were flooded by sea water, and at least 6-10 cm snow-ice layer was formed. Elevated deformation rates during the most powerful winter storms damaged the ice cover permanently such that the response to wind forcing increased by 60 %. As a result of a remote storm in April deformation processes opened about 4 % of the total area into leads with open water, while a similar amount of ice was deformed into pressure ridges. The strong winds also enhanced ocean mixing and increased ocean heat fluxes three-fold in the pycnocline from 4 to 12 W/m2. Ocean heat fluxes were extremely large (over 300 W/m2) during storms in regions where the warm Atlantic inflow is located close to surface over shallow topography. This resulted in very large (5-25 cm/day) bottom ice melt and in cases flooding due to heavy snow load. Storm events increased the carbon dioxide exchange between the atmosphere and ocean but also affected the pCO2 in surface waters

  4. Some Structural Observations of Self-Assembling, Fibrillar Gels Composed of Two-Directional Bolaform Arborols

    Energy Technology Data Exchange (ETDEWEB)

    Sun, J.

    2005-01-12

    Arborols are dumbbell shaped molecules (bolaform amphiphiles) in which a hydrophobic spacer separates two hydrophilic end groups. They are a valuable model for naturally occurring fibers, such as actin or amyloid. Applications to materials science can be envisioned. On cooling from warm aqueous or methanolic solutions, arborols spontaneously assemble into long fibers. When the solutions are above a certain concentration that depends on the hydrophilic/hydrophobic balance, this leads to thermally reversible gels stabilized by a mechanism that is poorly understood. With the help of wide angle X-ray scattering, details of the arborol fiber and gel structure were obtained on wet gels. The characteristic dimensions of the fibers vary in a sensible fashion with the molecular specifics. Solvent character appears to affect the average domain length of arborols stacked into fibers. Fluorescently labeled arborols were prepared. The label does not prevent incorporation into the fibrillar structure, rendering fibril bundles visible in wet gels. Bundles are visible in concentrated gels, but not in less concentrated sols. These results are consistent with observations of dried arborols using atomic force microscopy and with previously published freeze-fracture electron microscopy and small angle X-ray scattering experiments on dried gels.

  5. Wigner functions for a class of semi-direct product groups

    International Nuclear Information System (INIS)

    Krasowska, Anna E; Ali, S Twareque

    2003-01-01

    Following a general method proposed earlier, we construct here Wigner functions defined on coadjoint orbits of a class of semidirect product groups. The groups in question are such that their unitary duals consist purely of representations from the discrete series and each unitary irreducible representation is associated with a coadjoint orbit. The set of all coadjoint orbits (hence UIRs) is finite and their union is dense in the dual of the Lie algebra. The simple structure of the groups and the orbits enables us to compute the various quantities appearing in the definition of the Wigner function explicitly. A large number of examples, with potential use in image analysis, is worked out

  6. A direct observation the asteroid's structure from deep interior to regolith: why and how do it?

    Science.gov (United States)

    Herique, A.; Kofman, W. W.

    2013-12-01

    The internal structure of asteroids is still poorly known and has never been measured directly. Our knowledge is relying entirely on inferences from remote sensing observations of the surface, and theoretical modeling. Is the body a monolithic piece of rock or a rubble-pile, an aggregate of boulders held together by gravity and how much porosity it contains, both in the form of micro-scale or macro-scale porosity? What is the typical size of the constituent blocs? Are these blocs homogeneous or heterogeneous? Is the body a defunct or dormant comet and such MBC can become active? The body is covered by a regolith from whose properties remains largely unknown in term of depth, size distribution and spatial variation. Is resulting from fine particles re-accretion or from thermal fracturing? What are its coherent forces? How to model is thermal conductivity while this parameter is so important to estimate Yarkowsky and Yorp effects? Knowing asteroid deep interior and regolith structure is a key point for a better understanding of the asteroid accretion and dynamical evolution. There is no way to determine this from ground-based observation. Radar operating from a spacecraft is the only technique capable of achieving this science objective of characterizing the internal structure and heterogeneity from submetric to global scale for the science benefit as well as for the planetary defence and human exploration. The deep interior structure tomography requires low-frequency radar to penetrate throughout the complete body. The radar wave propagation delay and the received power are related to the complex dielectric permittivity (i.e to the composition and microporosity) and the small scale heterogeneities (scattering losses) while the spatial variation of the signal and the multiple paths provide information on the presence of heterogeneities (variations in composition or porosity), layers, ice lens. A partial coverage will provide "cuts" of the body when a dense coverage

  7. Direct Observations of Isoprene Secondary Organic Aerosol Formation in Ambient Cloud Droplets

    Science.gov (United States)

    Zelenyuk, A.; Bell, D.; Thornton, J. A.; Fast, J. D.; Shrivastava, M. B.; Berg, L. K.; Imre, D. G.; Mei, F.; Shilling, J.; Suski, K. J.; Liu, J.; Tomlinson, J. M.; Wang, J.

    2017-12-01

    Multiphase chemistry of isoprene photooxidation products has been shown to be one of the major sources of secondary organic aerosol (SOA) in the atmosphere. A number of recent studies indicate that aqueous aerosol phase provides a medium for reactive uptake of isoprene photooxidation products, and in particular, isomeric isoprene epoxydiols (IEPOX), with reaction rates and yields being dependent on aerosol acidity, water content, sulfate concentration, and organic coatings. However, very few studies focused on chemistry occurring within actual cloud droplets. We will present data acquired during recent Holistic Interactions of Shallow Clouds, Aerosols, and Land Ecosystems (HI-SCALE) Campaign, which provide direct evidence for IEPOX-SOA formation in cloud droplets. Single particle mass spectrometer, miniSPLAT, and a high-resolution, time-of-flight aerosol mass spectrometer were used to characterize the composition of aerosol particles and cloud droplet residuals, while a high-resolution, time-of-flight chemical ionization mass spectrometer (HR-ToF-CIMS) was used to characterize gas-phase compounds. We find that the composition of cloud droplet residuals was markedly different than that of aerosol particles sampled outside the cloud. Cloud droplet residuals were comprised of individual particles with high relative fractions of sulfate and nitrate and significant fraction of particles with mass spectra that are nearly identical to those of laboratory-generated IEPOX-SOA particles. The observed cloud-induced formation of IEPOX-SOA was accompanied by simultaneous decrease in measured concentrations of IEPOX and other gas-phase isoprene photooxidation products. Ultimately, the combined cloud, aerosol, and gas-phase measurements conducted during HI-SCALE will be used to develop and evaluate model treatments of aqueous-phase isoprene SOA formation.

  8. Directional Limits on Persistent Gravitational Waves from Advanced LIGO's First Observing Run.

    Science.gov (United States)

    Abbott, B P; Abbott, R; Abbott, T D; Abernathy, M R; Acernese, F; Ackley, K; Adams, C; Adams, T; Addesso, P; Adhikari, R X; Adya, V B; Affeldt, C; Agathos, M; Agatsuma, K; Aggarwal, N; Aguiar, O D; Aiello, L; Ain, A; Ajith, P; Allen, B; Allocca, A; Altin, P A; Ananyeva, A; Anderson, S B; Anderson, W G; Appert, S; Arai, K; Araya, M C; Areeda, J S; Arnaud, N; Arun, K G; Ascenzi, S; Ashton, G; Ast, M; Aston, S M; Astone, P; Aufmuth, P; Aulbert, C; Avila-Alvarez, A; Babak, S; Bacon, P; Bader, M K M; Baker, P T; Baldaccini, F; Ballardin, G; Ballmer, S W; Barayoga, J C; Barclay, S E; Barish, B C; Barker, D; Barone, F; Barr, B; Barsotti, L; Barsuglia, M; Barta, D; Bartlett, J; Bartos, I; Bassiri, R; Basti, A; Batch, J C; Baune, C; Bavigadda, V; Bazzan, M; Beer, C; Bejger, M; Belahcene, I; Belgin, M; Bell, A S; Berger, B K; Bergmann, G; Berry, C P L; Bersanetti, D; Bertolini, A; Betzwieser, J; Bhagwat, S; Bhandare, R; Bilenko, I A; Billingsley, G; Billman, C R; Birch, J; Birney, R; Birnholtz, O; Biscans, S; Biscoveanu, A S; Bisht, A; Bitossi, M; Biwer, C; Bizouard, M A; Blackburn, J K; Blackman, J; Blair, C D; Blair, D G; Blair, R M; Bloemen, S; Bock, O; Boer, M; Bogaert, G; Bohe, A; Bondu, F; Bonnand, R; Boom, B A; Bork, R; Boschi, V; Bose, S; Bouffanais, Y; Bozzi, A; Bradaschia, C; Brady, P R; Braginsky, V B; Branchesi, M; Brau, J E; Briant, T; Brillet, A; Brinkmann, M; Brisson, V; Brockill, P; Broida, J E; Brooks, A F; Brown, D A; Brown, D D; Brown, N M; Brunett, S; Buchanan, C C; Buikema, A; Bulik, T; Bulten, H J; Buonanno, A; Buskulic, D; Buy, C; Byer, R L; Cabero, M; Cadonati, L; Cagnoli, G; Cahillane, C; Calderón Bustillo, J; Callister, T A; Calloni, E; Camp, J B; Campbell, W; Canepa, M; Cannon, K C; Cao, H; Cao, J; Capano, C D; Capocasa, E; Carbognani, F; Caride, S; Casanueva Diaz, J; Casentini, C; Caudill, S; Cavaglià, M; Cavalier, F; Cavalieri, R; Cella, G; Cepeda, C B; Cerboni Baiardi, L; Cerretani, G; Cesarini, E; Chamberlin, S J; Chan, M; Chao, S; Charlton, P; Chassande-Mottin, E; Cheeseboro, B D; Chen, H Y; Chen, Y; Cheng, H-P; Chincarini, A; Chiummo, A; Chmiel, T; Cho, H S; Cho, M; Chow, J H; Christensen, N; Chu, Q; Chua, A J K; Chua, S; Chung, S; Ciani, G; Clara, F; Clark, J A; Cleva, F; Cocchieri, C; Coccia, E; Cohadon, P-F; Colla, A; Collette, C G; Cominsky, L; Constancio, M; Conti, L; Cooper, S J; Corbitt, T R; Cornish, N; Corsi, A; Cortese, S; Costa, C A; Coughlin, E; Coughlin, M W; Coughlin, S B; Coulon, J-P; Countryman, S T; Couvares, P; Covas, P B; Cowan, E E; Coward, D M; Cowart, M J; Coyne, D C; Coyne, R; Creighton, J D E; Creighton, T D; Cripe, J; Crowder, S G; Cullen, T J; Cumming, A; Cunningham, L; Cuoco, E; Dal Canton, T; Danilishin, S L; D'Antonio, S; Danzmann, K; Dasgupta, A; Da Silva Costa, C F; Dattilo, V; Dave, I; Davier, M; Davies, G S; Davis, D; Daw, E J; Day, B; Day, R; De, S; DeBra, D; Debreczeni, G; Degallaix, J; De Laurentis, M; Deléglise, S; Del Pozzo, W; Denker, T; Dent, T; Dergachev, V; De Rosa, R; DeRosa, R T; DeSalvo, R; Devenson, J; Devine, R C; Dhurandhar, S; Díaz, M C; Di Fiore, L; Di Giovanni, M; Di Girolamo, T; Di Lieto, A; Di Pace, S; Di Palma, I; Di Virgilio, A; Doctor, Z; Dolique, V; Donovan, F; Dooley, K L; Doravari, S; Dorrington, I; Douglas, R; Dovale Álvarez, M; Downes, T P; Drago, M; Drever, R W P; Driggers, J C; Du, Z; Ducrot, M; Dwyer, S E; Edo, T B; Edwards, M C; Effler, A; Eggenstein, H-B; Ehrens, P; Eichholz, J; Eikenberry, S S; Essick, R C; Etienne, Z; Etzel, T; Evans, M; Evans, T M; Everett, R; Factourovich, M; Fafone, V; Fair, H; Fairhurst, S; Fan, X; Farinon, S; Farr, B; Farr, W M; Fauchon-Jones, E J; Favata, M; Fays, M; Fehrmann, H; Fejer, M M; Fernández Galiana, A; Ferrante, I; Ferreira, E C; Ferrini, F; Fidecaro, F; Fiori, I; Fiorucci, D; Fisher, R P; Flaminio, R; Fletcher, M; Fong, H; Forsyth, S S; Fournier, J-D; Frasca, S; Frasconi, F; Frei, Z; Freise, A; Frey, R; Frey, V; Fries, E M; Fritschel, P; Frolov, V V; Fulda, P; Fyffe, M; Gabbard, H; Gadre, B U; Gaebel, S M; Gair, J R; Gammaitoni, L; Gaonkar, S G; Garufi, F; Gaur, G; Gayathri, V; Gehrels, N; Gemme, G; Genin, E; Gennai, A; George, J; Gergely, L; Germain, V; Ghonge, S; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S; Giaime, J A; Giardina, K D; Giazotto, A; Gill, K; Glaefke, A; Goetz, E; Goetz, R; Gondan, L; González, G; Gonzalez Castro, J M; Gopakumar, A; Gorodetsky, M L; Gossan, S E; Gosselin, M; Gouaty, R; Grado, A; Graef, C; Granata, M; Grant, A; Gras, S; Gray, C; Greco, G; Green, A C; Groot, P; Grote, H; Grunewald, S; Guidi, G M; Guo, X; Gupta, A; Gupta, M K; Gushwa, K E; Gustafson, E K; Gustafson, R; Hacker, J J; Hall, B R; Hall, E D; Hammond, G; Haney, M; Hanke, M M; Hanks, J; Hanna, C; Hannam, M D; Hanson, J; Hardwick, T; Harms, J; Harry, G M; Harry, I W; Hart, M J; Hartman, M T; Haster, C-J; Haughian, K; Healy, J; Heidmann, A; Heintze, M C; Heitmann, H; Hello, P; Hemming, G; Hendry, M; Heng, I S; Hennig, J; Henry, J; Heptonstall, A W; Heurs, M; Hild, S; Hoak, D; Hofman, D; Holt, K; Holz, D E; Hopkins, P; Hough, J; Houston, E A; Howell, E J; Hu, Y M; Huerta, E A; Huet, D; Hughey, B; Husa, S; Huttner, S H; Huynh-Dinh, T; Indik, N; Ingram, D R; Inta, R; Isa, H N; Isac, J-M; Isi, M; Isogai, T; Iyer, B R; Izumi, K; Jacqmin, T; Jani, K; Jaranowski, P; Jawahar, S; Jiménez-Forteza, F; Johnson, W W; Jones, D I; Jones, R; Jonker, R J G; Ju, L; Junker, J; Kalaghatgi, C V; Kalogera, V; Kandhasamy, S; Kang, G; Kanner, J B; Karki, S; Karvinen, K S; Kasprzack, M; Katsavounidis, E; Katzman, W; Kaufer, S; Kaur, T; Kawabe, K; Kéfélian, F; Keitel, D; Kelley, D B; Kennedy, R; Key, J S; Khalili, F Y; Khan, I; Khan, S; Khan, Z; Khazanov, E A; Kijbunchoo, N; Kim, Chunglee; Kim, J C; Kim, Whansun; Kim, W; Kim, Y-M; Kimbrell, S J; King, E J; King, P J; Kirchhoff, R; Kissel, J S; Klein, B; Kleybolte, L; Klimenko, S; Koch, P; Koehlenbeck, S M; Koley, S; Kondrashov, V; Kontos, A; Korobko, M; Korth, W Z; Kowalska, I; Kozak, D B; Krämer, C; Kringel, V; Królak, A; Kuehn, G; Kumar, P; Kumar, R; Kuo, L; Kutynia, A; Lackey, B D; Landry, M; Lang, R N; Lange, J; Lantz, B; Lanza, R K; Lartaux-Vollard, A; Lasky, P D; Laxen, M; Lazzarini, A; Lazzaro, C; Leaci, P; Leavey, S; Lebigot, E O; Lee, C H; Lee, H K; Lee, H M; Lee, K; Lehmann, J; Lenon, A; Leonardi, M; Leong, J R; Leroy, N; Letendre, N; Levin, Y; Li, T G F; Libson, A; Littenberg, T B; Liu, J; Lockerbie, N A; Lombardi, A L; London, L T; Lord, J E; Lorenzini, M; Loriette, V; Lormand, M; Losurdo, G; Lough, J D; Lousto, C O; Lovelace, G; Lück, H; Lundgren, A P; Lynch, R; Ma, Y; Macfoy, S; Machenschalk, B; MacInnis, M; Macleod, D M; Magaña-Sandoval, F; Majorana, E; Maksimovic, I; Malvezzi, V; Man, N; Mandic, V; Mangano, V; Mansell, G L; Manske, M; Mantovani, M; Marchesoni, F; Marion, F; Márka, S; Márka, Z; Markosyan, A S; Maros, E; Martelli, F; Martellini, L; Martin, I W; Martynov, D V; Mason, K; Masserot, A; Massinger, T J; Masso-Reid, M; Mastrogiovanni, S; Matas, A; Matichard, F; Matone, L; Mavalvala, N; Mazumder, N; McCarthy, R; McClelland, D E; McCormick, S; McGrath, C; McGuire, S C; McIntyre, G; McIver, J; McManus, D J; McRae, T; McWilliams, S T; Meacher, D; Meadors, G D; Meidam, J; Melatos, A; Mendell, G; Mendoza-Gandara, D; Mercer, R A; Merilh, E L; Merzougui, M; Meshkov, S; Messenger, C; Messick, C; Metzdorff, R; Meyers, P M; Mezzani, F; Miao, H; Michel, C; Middleton, H; Mikhailov, E E; Milano, L; Miller, A L; Miller, A; Miller, B B; Miller, J; Millhouse, M; Minenkov, Y; Ming, J; Mirshekari, S; Mishra, C; Mitra, S; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Moggi, A; Mohan, M; Mohapatra, S R P; Montani, M; Moore, B C; Moore, C J; Moraru, D; Moreno, G; Morriss, S R; Mours, B; Mow-Lowry, C M; Mueller, G; Muir, A W; Mukherjee, Arunava; Mukherjee, D; Mukherjee, S; Mukund, N; Mullavey, A; Munch, J; Muniz, E A M; Murray, P G; Mytidis, A; Napier, K; Nardecchia, I; Naticchioni, L; Nelemans, G; Nelson, T J N; Neri, M; Nery, M; Neunzert, A; Newport, J M; Newton, G; Nguyen, T T; Nielsen, A B; Nissanke, S; Nitz, A; Noack, A; Nocera, F; Nolting, D; Normandin, M E N; Nuttall, L K; Oberling, J; Ochsner, E; Oelker, E; Ogin, G H; Oh, J J; Oh, S H; Ohme, F; Oliver, M; Oppermann, P; Oram, Richard J; O'Reilly, B; O'Shaughnessy, R; Ottaway, D J; Overmier, H; Owen, B J; Pace, A E; Page, J; Pai, A; Pai, S A; Palamos, J R; Palashov, O; Palomba, C; Pal-Singh, A; Pan, H; Pankow, C; Pannarale, F; Pant, B C; Paoletti, F; Paoli, A; Papa, M A; Paris, H R; Parker, W; Pascucci, D; Pasqualetti, A; Passaquieti, R; Passuello, D; Patricelli, B; Pearlstone, B L; Pedraza, M; Pedurand, R; Pekowsky, L; Pele, A; Penn, S; Perez, C J; Perreca, A; Perri, L M; Pfeiffer, H P; Phelps, M; Piccinni, O J; Pichot, M; Piergiovanni, F; Pierro, V; Pillant, G; Pinard, L; Pinto, I M; Pitkin, M; Poe, M; Poggiani, R; Popolizio, P; Post, A; Powell, J; Prasad, J; Pratt, J W W; Predoi, V; Prestegard, T; Prijatelj, M; Principe, M; Privitera, S; Prodi, G A; Prokhorov, L G; Puncken, O; Punturo, M; Puppo, P; Pürrer, M; Qi, H; Qin, J; Qiu, S; Quetschke, V; Quintero, E A; Quitzow-James, R; Raab, F J; Rabeling, D S; Radkins, H; Raffai, P; Raja, S; Rajan, C; Rakhmanov, M; Rapagnani, P; Raymond, V; Razzano, M; Re, V; Read, J; Regimbau, T; Rei, L; Reid, S; Reitze, D H; Rew, H; Reyes, S D; Rhoades, E; Ricci, F; Riles, K; Rizzo, M; Robertson, N A; Robie, R; Robinet, F; Rocchi, A; Rolland, L; Rollins, J G; Roma, V J; Romano, J D; Romano, R; Romie, J H; Rosińska, D; Rowan, S; Rüdiger, A; Ruggi, P; Ryan, K; Sachdev, S; Sadecki, T; Sadeghian, L; Sakellariadou, M; Salconi, L; Saleem, M; Salemi, F; Samajdar, A; Sammut, L; Sampson, L M; Sanchez, E J; Sandberg, V; Sanders, J R; Sassolas, B; Sathyaprakash, B S; Saulson, P R; Sauter, O; Savage, R L; Sawadsky, A; Schale, P; Scheuer, J; Schlassa, S; Schmidt, E; Schmidt, J; Schmidt, P; Schnabel, R; Schofield, R M S; Schönbeck, A; Schreiber, E; Schuette, D; Schutz, B F; Schwalbe, S G; Scott, J; Scott, S M; Sellers, D; Sengupta, A S; Sentenac, D; Sequino, V; Sergeev, A; Setyawati, Y; Shaddock, D A; Shaffer, T J; Shahriar, M S; Shapiro, B; Shawhan, P; Sheperd, A; Shoemaker, D H; Shoemaker, D M; Siellez, K; Siemens, X; Sieniawska, M; Sigg, D; Silva, A D; Singer, A; Singer, L P; Singh, A; Singh, R; Singhal, A; Sintes, A M; Slagmolen, B J J; Smith, B; Smith, J R; Smith, R J E; Son, E J; Sorazu, B; Sorrentino, F; Souradeep, T; Spencer, A P; Srivastava, A K; Staley, A; Steinke, M; Steinlechner, J; Steinlechner, S; Steinmeyer, D; Stephens, B C; Stevenson, S P; Stone, R; Strain, K A; Straniero, N; Stratta, G; Strigin, S E; Sturani, R; Stuver, A L; Summerscales, T Z; Sun, L; Sunil, S; Sutton, P J; Swinkels, B L; Szczepańczyk, M J; Tacca, M; Talukder, D; Tanner, D B; Tao, D; Tápai, M; Taracchini, A; Taylor, R; Theeg, T; Thomas, E G; Thomas, M; Thomas, P; Thorne, K A; Thrane, E; Tippens, T; Tiwari, S; Tiwari, V; Tokmakov, K V; Toland, K; Tomlinson, C; Tonelli, M; Tornasi, Z; Torrie, C I; Töyrä, D; Travasso, F; Traylor, G; Trifirò, D; Trinastic, J; Tringali, M C; Trozzo, L; Tse, M; Tso, R; Turconi, M; Tuyenbayev, D; Ugolini, D; Unnikrishnan, C S; Urban, A L; Usman, S A; Vahlbruch, H; Vajente, G; Valdes, G; van Bakel, N; van Beuzekom, M; van den Brand, J F J; Van Den Broeck, C; Vander-Hyde, D C; van der Schaaf, L; van Heijningen, J V; van Veggel, A A; Vardaro, M; Varma, V; Vass, S; Vasúth, M; Vecchio, A; Vedovato, G; Veitch, J; Veitch, P J; Venkateswara, K; Venugopalan, G; Verkindt, D; Vetrano, F; Viceré, A; Viets, A D; Vinciguerra, S; Vine, D J; Vinet, J-Y; Vitale, S; Vo, T; Vocca, H; Vorvick, C; Voss, D V; Vousden, W D; Vyatchanin, S P; Wade, A R; Wade, L E; Wade, M; Walker, M; Wallace, L; Walsh, S; Wang, G; Wang, H; Wang, M; Wang, Y; Ward, R L; Warner, J; Was, M; Watchi, J; Weaver, B; Wei, L-W; Weinert, M; Weinstein, A J; Weiss, R; Wen, L; Weßels, P; Westphal, T; Wette, K; Whelan, J T; Whiting, B F; Whittle, C; Williams, D; Williams, R D; Williamson, A R; Willis, J L; Willke, B; Wimmer, M H; Winkler, W; Wipf, C C; Wittel, H; Woan, G; Woehler, J; Worden, J; Wright, J L; Wu, D S; Wu, G; Yam, W; Yamamoto, H; Yancey, C C; Yap, M J; Yu, Hang; Yu, Haocun; Yvert, M; Zadrożny, A; Zangrando, L; Zanolin, M; Zendri, J-P; Zevin, M; Zhang, L; Zhang, M; Zhang, T; Zhang, Y; Zhao, C; Zhou, M; Zhou, Z; Zhu, S J; Zhu, X J; Zucker, M E; Zweizig, J

    2017-03-24

    We employ gravitational-wave radiometry to map the stochastic gravitational wave background expected from a variety of contributing mechanisms and test the assumption of isotropy using data from the Advanced Laser Interferometer Gravitational Wave Observatory's (aLIGO) first observing run. We also search for persistent gravitational waves from point sources with only minimal assumptions over the 20-1726 Hz frequency band. Finding no evidence of gravitational waves from either point sources or a stochastic background, we set limits at 90% confidence. For broadband point sources, we report upper limits on the gravitational wave energy flux per unit frequency in the range F_{α,Θ}(f)<(0.1-56)×10^{-8}    erg cm^{-2} s^{-1} Hz^{-1}(f/25  Hz)^{α-1} depending on the sky location Θ and the spectral power index α. For extended sources, we report upper limits on the fractional gravitational wave energy density required to close the Universe of Ω(f,Θ)<(0.39-7.6)×10^{-8}  sr^{-1}(f/25  Hz)^{α} depending on Θ and α. Directed searches for narrowband gravitational waves from astrophysically interesting objects (Scorpius X-1, Supernova 1987 A, and the Galactic Center) yield median frequency-dependent limits on strain amplitude of h_{0}<(6.7,5.5,  and  7.0)×10^{-25}, respectively, at the most sensitive detector frequencies between 130-175 Hz. This represents a mean improvement of a factor of 2 across the band compared to previous searches of this kind for these sky locations, considering the different quantities of strain constrained in each case.

  9. Direct observation of backbone planarization via side-chain alignment in single bulky-substituted polythiophenes

    Science.gov (United States)

    Raithel, Dominic; Simine, Lena; Pickel, Sebastian; Schötz, Konstantin; Panzer, Fabian; Baderschneider, Sebastian; Schiefer, Daniel; Lohwasser, Ruth; Köhler, Jürgen; Thelakkat, Mukundan; Sommer, Michael; Köhler, Anna; Rossky, Peter J.; Hildner, Richard

    2018-03-01

    The backbone conformation of conjugated polymers affects, to a large extent, their optical and electronic properties. The usually flexible substituents provide solubility and influence the packing behavior of conjugated polymers in films or in bad solvents. However, the role of the side chains in determining and potentially controlling the backbone conformation, and thus the optical and electronic properties on the single polymer level, is currently under debate. Here, we investigate directly the impact of the side chains by studying the bulky-substituted poly(3-(2,5-dioctylphenyl)thiophene) (PDOPT) and the common poly(3-hexylthiophene) (P3HT), both with a defined molecular weight and high regioregularity, using low-temperature single-chain photoluminescence (PL) spectroscopy and quantum-classical simulations. Surprisingly, the optical transition energy of PDOPT is significantly (˜2,000 cm‑1 or 0.25 eV) red-shifted relative to P3HT despite a higher static and dynamic disorder in the former. We ascribe this red shift to a side-chain induced backbone planarization in PDOPT, supported by temperature-dependent ensemble PL spectroscopy. Our atomistic simulations reveal that the bulkier 2,5-dioctylphenyl side chains of PDOPT adopt a clear secondary helical structural motif and thus protect conjugation, i.e., enforce backbone planarity, whereas, for P3HT, this is not the case. These different degrees of planarity in both thiophenes do not result in different conjugation lengths, which we found to be similar. It is rather the stronger electronic coupling between the repeating units in the more planar PDOPT which gives rise to the observed spectral red shift as well as to a reduced calculated electron‑hole polarization.

  10. Rates of ingestion and their variability between individual calanoid copepods: Direct observations

    Energy Technology Data Exchange (ETDEWEB)

    Paffenhoefer, G.A.; Lewis, K.D. [Skidaway Inst. of Oceanography, Savannah, GA (United States); Bundy, M.H. [Skidaway Inst. of Oceanography, Savannah, GA (United States)]|[Alfred-Wegener-Institut fuer Polar- und Meeresforschung, Bremerhaven (Germany). Inst. fuer Fernerkundung (IFE); Metz, C. [Alfred-Wegener-Institut fuer Polar- und Meeresforschung, Bremerhaven (Germany). Inst. fuer Fernerkundung (IFE)

    1995-12-01

    The goals of this study were to determine rates of ingestion and fecal pellet release, and their variability, for individual planktonic copepods over extended periods of time (>20 min). Ingestions and rejections of individual cells of the diatom Thalassiosira eccentrica by a adult females of the calanoid Paracalanus aculeatus were directly quantified by observing individual copepods continuously at cell concentrations ranging from 0.1 to 1.2 mm{sup 3} l{sup {minus}1}. Average ingestion rates increased with increasing food concentration, but were not significantly different between 0.3 and 1.0 mm{sup 3} l{sup {minus}1} (9.8 and 32.7 {mu}g Cl{sup {minus}1}) of T.eccentrica. Rates of cell rejections were low and similar at 0.1 and 0.3. but were significantly higher at 1.0 mm{sup 3} l{sup {minus}1}. The coefficients of variation for average ingestion rates of individual copepods hardly differed between food concentrations, ranging from 17 to 22%, and were close to those for average fecal pellet release intervals which ranged from 15 to 21%. A comparison between individuals at each food concentration found no significant differences at 1.0; at 0.1 and 0.3 mm{sup 3} l{sup {minus}1}, respectively, ingestion rates of four out of five females did not differ significantly from each other. Average intervals between fecal pellet releases were similar at 0.3 and 1.0 mm{sup 3} l{sup {minus}1}. Fecal pellet release intervals between individuals were significantly different at each food concentration; these significant differences were attributed to rather narrow ranges of pellet release intervals of each individual female. Potential sources/causes of variability in the sizes and rates of copepods in the ocean are evaluated.

  11. The New Worlds Observer: An Optimal Path to Direct Study of Earth-like Planets

    Science.gov (United States)

    Cash, Webster C., Jr.; New Worlds Study Team

    2009-01-01

    Direct detection and spectroscopic study of the planets around the nearby stars is generally recognized as a prime goal of astronomy. The New Worlds Observer mission concept is being studied as an Astrophysics Strategic Mission Concept Study for this purpose. NWO features two spacecraft: a general purpose 4m telescope that operates from the UV to the Near IR, and a starshade, a flower-shaped occulter about 50m in diameter flying in alignment about 70,000km away. Our study shows this is the most effective way to map nearby planetary systems. In this poster we will show that NWO can return much more science than any of the competing approaches at any given price point. Images will show dust and debris down to a fraction of our zodiacal light level. Planets fainter than the Earth can be seen from the Habitable Zone outward, at distances up to 20pc. High throughput and low noise enable immediate follow-up spectroscopy of discovered planets. NWO can discover many more Earth-like planets than all competing approaches including astrometric, interferometric, and internal coronagraphic. Within hours of discovery, a high quality spectrum can determine the true nature of the exoplanet and open the search for biomarkers and life. Over half of the time will be spent with the starshade in transit to the next target. During those times the telescope will be available to for general astrophysics purposes. Operating from the ultraviolet to the near infrared, this will be a true HST follow-on. The study shows all needed technologies already exist. The cost scales primarily with telescope size. The mission is definitely within the financial and technical reach of NASA for the coming decade.

  12. The New Worlds Observer: Direct Detection and Study of Exoplanets from the Habitable Zone Outward

    Science.gov (United States)

    Cash, Webster C.; New Worlds Study Team

    2009-01-01

    Direct detection and spectroscopic study of the planets around the nearby stars is generally recognized as a prime goal of astronomy. The New Worlds Observer mission concept is being studied as an Astrophysics Strategic Mission Concept Study for this purpose. NWO features two spacecraft: a general purpose 4m telescope that operates from the UV to the Near IR, and a starshade, a flower-shaped occulter about 50m in diameter flying in alignment about 70,000km away. Our study shows this is the most effective way to map nearby planetary systems. Images will show dust and debris down to a fraction of our zodiacal light level. Planets fainter than the Earth can be seen from the Habitable Zone outward, at distances up to 20pc. High throughput and low noise enable immediate follow-up spectroscopy of discovered planets. NWO can discover many more Earth-like planets than all competing approaches including astrometric, interferometric, and internal coronagraphic. Within hours of discovery, a high quality spectrum can determine the true nature of the exoplanet and open the search for biomarkers and life. Over half of the time will be spent with the starshade in transit to the next target. During those times the telescope will be available to for general astrophysics purposes. Operating from the ultraviolet to the near infrared, this will be a true HST follow-on. The study shows all needed technologies already exist. The cost scales primarily with telescope size. The mission is definitely within the financial and technical reach of NASA for the coming decade.

  13. Digital Processing for Modifying and Rearranging Rectilinear and Section Scan Data under Direct Observation

    Energy Technology Data Exchange (ETDEWEB)

    Kuhl, D. E.; Edwards, R. Q. [University of Pennsylvania, Philadelphia, PA (United States)

    1969-01-15

    Our digital processor for scan data is an on-site instrument that is intermediate in complexity between conventional optical processing devices and large digital computers. It is designed to provide for a wide and flexible range of secondary data operations, direct picture display on a CRT screen, and full operator control of both processing and display operations at the time of viewing. The instrument does not require the user to learn complicated programing schemes. The operator is expected to be a physician who will control the parameters of interest by punching preset buttons on a keyboard while observing changes displayed on a CRT screen. The system functions primarily as an investigative tool for studying perception of scan information and ways of making this information more meaningful. Data operations include data bounding, spatial averaging, iso-count line generation, image addition and subtraction, and several forms of quantitative read-out for analysis of regional data. The instrument is intended to serve as a central processor and reader for data from several units. Investigations with this processor have served as a source of information leading to the design of more simple processing devices suitable for wider acceptance. For example, the Mark III rectilinear and transverse section brain scanner that has evolved from this project is expected to be a practical improvement of the brain study method. This instrument is designed especially for rapid brain scanning using {sup 99m}Tc pertechnetate. It has a self-contained computer, integrated digital circuits for compactness and economy, and provision for transverse section scanning. The advantages of this system are that it provides a more thorough study using both transverse section and rectilinear modes, rapid performance, precise orientation of section and rectilinear views to the patient position, efficient transfer of information between physician and machine during studies, and economy of design

  14. Social communication with virtual agents: The effects of body and gaze direction on attention and emotional responding in human observers.

    Science.gov (United States)

    Marschner, Linda; Pannasch, Sebastian; Schulz, Johannes; Graupner, Sven-Thomas

    2015-08-01

    In social communication, the gaze direction of other persons provides important information to perceive and interpret their emotional response. Previous research investigated the influence of gaze by manipulating mutual eye contact. Therefore, gaze and body direction have been changed as a whole, resulting in only congruent gaze and body directions (averted or directed) of another person. Here, we aimed to disentangle these effects by using short animated sequences of virtual agents posing with either direct or averted body or gaze. Attention allocation by means of eye movements, facial muscle response, and emotional experience to agents of different gender and facial expressions were investigated. Eye movement data revealed longer fixation durations, i.e., a stronger allocation of attention, when gaze and body direction were not congruent with each other or when both were directed towards the observer. This suggests that direct interaction as well as incongruous signals increase the demands of attentional resources in the observer. For the facial muscle response, only the reaction of muscle zygomaticus major revealed an effect of body direction, expressed by stronger activity in response to happy expressions for direct compared to averted gaze when the virtual character's body was directed towards the observer. Finally, body direction also influenced the emotional experience ratings towards happy expressions. While earlier findings suggested that mutual eye contact is the main source for increased emotional responding and attentional allocation, the present results indicate that direction of the virtual agent's body and head also plays a minor but significant role. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Position, swimming direction and group size of fin whales (Balaenoptera physalus in the presence of a fast-ferry in the Bay of Biscay

    Directory of Open Access Journals (Sweden)

    Ana S. Aniceto

    2016-07-01

    Full Text Available We analyze group size, swimming direction and the orientation of fin whales relative to a fast ferry in the Bay of Biscay. Fin whale groups (≥3 individuals were on average closer to the vessel than single individuals and pairs (F1,114 = 4.94, p = 0.028 and were more often observed within a high-risk angle ahead of the ferry (binomial probability: p = 7.60 × 10−11. Also, small groups tend to swim in the opposite direction (heading of 180° of the ferry at the starboard side (binomial test: p = 6.86 × 10−5 and at the portside (binomial test: p = 0.0156. These findings provide valuable information to improve shipping management procedures in areas at high risk for collisions.

  16. Pd(II)-catalyzed di-o-olefination of carbazoles directed by the protecting N-(2-pyridyl)sulfonyl group.

    Science.gov (United States)

    Urones, Beatriz; Gómez Arrayás, Ramón; Carretero, Juan Carlos

    2013-03-01

    Despite the significance of carbazole in pharmacy and material science, examples of the direct C-H functionalization of this privileged unit are quite rare. The N-(2-pyridyl)sulfonyl group enables the Pd(II)-catalyzed ortho-olefination of carbazoles and related systems, acting as both a directing and readily removable protecting group. This method features ample structural versatility, affording typically the double ortho-olefination products (at C1 and C8) in satisfactory yields and complete regiocontrol. The application of this procedure to related heterocyclic systems, such as indoline, is also described.

  17. Quantitative determination of acidic groups in functionalized graphene by direct titration

    Czech Academy of Sciences Publication Activity Database

    Ederer, J.; Janoš, P.; Ecorchard, Petra; Štengl, Václav; Bělčická, Zuzana; Šťastný, Martin; Pop-Georgievski, Ognen; Dohnal, V.

    2016-01-01

    Roč. 103, JUN (2016), s. 44-53 ISSN 1381-5148 R&D Projects: GA ČR(CZ) GA14-05146S Institutional support: RVO:61388980 ; RVO:61389013 Keywords : Acid-base titration * Carboxylic functional groups * Graphene oxide * Phenolic functional groups * Proton-binding model Subject RIV: CA - Inorganic Chemistry ; CD - Macromolecular Chemistry (UMCH-V) Impact factor: 3.151, year: 2016

  18. A Preliminary Human Rights Analysis of the Working Group Report and Recommendations on Direct Provision

    OpenAIRE

    Thornton, Liam

    2015-01-01

    Overall, the Report contains a mix of significant recommendations on the protection process and processing of asylum claims. However, I argue, there are significant concerns with the recommendations that have emerged as regards direct provision accommodation and supports for asylum applicants. The focus of this working paper relates to categorising some of the recommendations contained in the McMahon Report and providing some initial analysis. This analysis is not an exhaustive exploration...

  19. Visibility of St Lawrence belugas to aerial photography, estimated by direct observation

    Directory of Open Access Journals (Sweden)

    Michael CS Kingsley

    2002-07-01

    Full Text Available The depleted population of belugas (Delphinapterus leucas inhabiting the St Lawrence estuary, Canada, was monitored by periodic photographic aerial surveys. In order to correct counts made on aerial survey film and to obtain an estimate of the true size of the population, the diving behaviour and the visibility from the air of these animals was studied. A Secchi-disk turbidity survey in the belugas’ summer range showed that water clarity varied between 1.5 m and 11.6 m. By studying aerial photographs of sheet-plastic models of belugas that had been sunk to different depths below the surface, we found that models of white adults could be seen down to about the same depth as a Secchi disk, but no deeper. Smaller models of dark-grey juveniles could only be seen down to about 50% of Secchi-disk depth. By observing groups of belugas from a hovering helicopter and recording their disappearances and re-appearances, it was found that they were visible for 44.3% of the time, and that an appropriate correction for single photographs would be to multiply the photographic count by about 222% (SE 20%. For surveys in which there was overlap between adjacent frames, the estimated correction would be 209% (SE 16%. This correction factor was slightly conservative and gave an estimate of the true size of the population, based on a single survey, of 1,202 belugas (SE 189 in 1997. An estimate for 1997 based on smoothing 5 surveys 1988–1997 was 1,238 (SE 119.

  20. The Directly Observed Therapy Short-Course (DOTS strategy in Samara Oblast, Russian Federation

    Directory of Open Access Journals (Sweden)

    Nikolayevskyy V

    2006-03-01

    Full Text Available Abstract Background The World Health Organisation (WHO defines Russia as one of the 22 highest-burden countries for tuberculosis (TB. The WHO Directly Observed Treatment Short Course (DOTS strategy employing a standardised treatment for 6 months produces the highest cure rates for drug sensitive TB. The Russian TB service traditionally employed individualised treatment. The purpose of this study was to implement a DOTS programme in the civilian and prison sectors of Samara Region of Russia, describe the clinical features and outcomes of recruited patients, determine the proportion of individuals in the cohorts who were infected with drug resistant TB, the degree to which resistance was attributed to the Beijing TB strain family and establish risk factors for drug resistance. Methods prospective study Results 2,099 patients were recruited overall. Treatment outcomes were analysed for patients recruited up to the third quarter of 2003 (n = 920. 75.3% of patients were successfully treated. Unsuccessful outcomes occurred in 7.3% of cases; 3.6% of patients died during treatment, with a significantly higher proportion of smear-positive cases dying compared to smear-negative cases. 14.0% were lost and transferred out. A high proportion of new cases (948 sequential culture-proven TB cases had tuberculosis that was resistant to first-line drugs; (24.9% isoniazid resistant; 20.3% rifampicin resistant; 17.3% multidrug resistant tuberculosis. Molecular epidemiological analysis demonstrated that half of all isolated strains (50.7%; 375/740 belonged to the Beijing family. Drug resistance including MDR TB was strongly associated with infection with the Beijing strain (for MDR TB, 35.2% in Beijing strains versus 9.5% in non-Beijing strains, OR-5.2. Risk factors for multidrug resistant tuberculosis were: being a prisoner (OR 4.4, having a relapse of tuberculosis (OR 3.5, being infected with a Beijing family TB strain (OR 6.5 and having an unsuccessful outcome

  1. Teaching Direct Practice Techniques for Work with Elders with Alzheimer's Disease: A Simulated Group Experience.

    Science.gov (United States)

    Kane, Michael N.

    2003-01-01

    A role-play exercise about Alzheimer's disease was designed to teach group work with memory-impaired elders. Written comments from 26 social work students revealed four outcomes: demystifying practical knowledge, respect for diversity among memory-impaired individuals, increased awareness of elders' internal states, and awareness of the challenges…

  2. Quantum algorithms for the hidden subgroup problem on some semi-direct product groups by reduction to Abelian cases

    International Nuclear Information System (INIS)

    Chi, Dong Pyo; Kim, Jeong San; Lee, Soojoon

    2006-01-01

    We consider the hidden subgroup problem on the semi-direct product of cyclic groups Z N -bar Z p , where p is a prime that does not divide p j -1 for any of the prime factors p j of N, and show that the hidden subgroup problem can be reduced to other ones for which solutions are already known

  3. Palladium-Catalyzed C-H Functionalization Using Guanidine as a Directing Group: Ortho Arylation and Olefination of Arylguanidines

    Science.gov (United States)

    Shao, Jiaan; Chen, Wenteng; Giulianotti, Marc A.; Houghten, Richard A.; Yu, Yongping

    2012-01-01

    Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination respectively. PMID:23095022

  4. A Comparison of Assessment Tools: Is Direct Observation an Improvement Over Objective Structured Clinical Examinations for Communications Skills Evaluation?

    Science.gov (United States)

    Goch, Abraham M; Karia, Raj; Taormina, David; Kalet, Adina; Zuckerman, Joseph; Egol, Kenneth A; Phillips, Donna

    2018-04-01

    Evaluation of resident physicians' communications skills is a challenging task and is increasingly accomplished with standardized examinations. There exists a need to identify the effective, efficient methods for assessment of communications skills. We compared objective structured clinical examination (OSCE) and direct observation as approaches for assessing resident communications skills. We conducted a retrospective cohort analysis of orthopaedic surgery resident physicians at a single tertiary care academic institution, using the Institute for Healthcare Communication "4 Es" model for effective communication. Data were collected between 2011 and 2015. A total of 28 residents, each with OSCE and complete direct observation assessment checklists, were included in the analysis. Residents were included if they had 1 OSCE assessment and 2 or more complete direct observation assessments. There were 28 of a possible 59 residents (47%) included. A total of 89% (25 of 28) of residents passed the communications skills OSCE; only 54% (15 of 28) of residents passed the direct observation communications assessment. There was a positive, moderate correlation between OSCE and direct observation scores overall ( r  = 0.415, P  = .028). There was no agreement between OSCE and direct observation in categorizing residents into passing and failing scores (κ = 0.205, P  = .16), after adjusting for chance agreement. Our results suggest that OSCE and direct observation tools provide different insights into resident communications skills (simulation of rare and challenging situations versus real-life daily encounters), and may provide useful perspectives on resident communications skills in different contexts.

  5. Direct laboratory observation of fluid distribution and its influence on acoustic properties of patchy saturated rocks

    Science.gov (United States)

    Lebedev, M.; Clennell, B.; Pervukhina, M.; Shulakova, V.; Mueller, T.; Gurevich, B.

    2009-04-01

    samples (38 mm in diameter, approximately 60 mm long) were dried in oven under reduced pressure. In dynamic saturation experiments, samples were jacketed in the experimental cell, made from transparent for X-radiation material (PMMA). Distillate water was injected into the sample from the one side. Fluid distribution in such "dynamic" experiment: both spatial and time dependant was measured using X-ray Computer Tomograph (CT) with resolution 0.2 x 0.2 x 1 mm3. Velocities (Vp, and Vs) at ultrasonic frequency of 1 MHz, were measured in the direction perpendicular to initial direction of the fluid flow injection. Sample saturation was estimated from the CT results. In "quasi static" experiments samples were saturated during long period of time (over 2 weeks) to achieve uniform distribution of liquid inside the sample. Saturation was determined by measurement of the weight of water fraction. All experiments were performed at laboratory environments at temperature 25 C. Ultrasonic velocities and fluid saturations were measured simultaneously during water injection into sandstone core samples. The experimental results obtained on low-permeability samples show that at low saturation values the velocity-saturation dependence can be described by the Gassmann-Wood relationship. However, with increasing saturation a sharp increase of P-wave velocity is observed, eventually approaching the Gassmann-Hill relationship. We connect the characteristics of the transition behavior of the velocity-saturation relationships to the increasing size of the patches inside the rock sample. In particular, we show that for relatively large fluid injection rate this transition occurs at smaller degrees of saturation as compared with high injection rate. We model the experimental data using the so-called White model (Toms 2007) that assumes fluid patch distribution as a periodic assemblage of concentric spheres. We can observe reasonable agreement between experimental results and theoretical

  6. Inter-rater reliability of direct observations of the physical and psychosocial working conditions in eldercare

    DEFF Research Database (Denmark)

    Karstad, Kristina; Rugulies, Reiner; Skotte, Jørgen

    2018-01-01

    The aim of the study was to develop and evaluate the reliability of the "Danish observational study of eldercare work and musculoskeletal disorders" (DOSES) observation instrument to assess physical and psychosocial risk factors for musculoskeletal disorders (MSD) in eldercare work. During 1.5 ye...... is appropriate for assessing physical and psychosocial risk factors for MSD among eldercare workers.......The aim of the study was to develop and evaluate the reliability of the "Danish observational study of eldercare work and musculoskeletal disorders" (DOSES) observation instrument to assess physical and psychosocial risk factors for musculoskeletal disorders (MSD) in eldercare work. During 1...

  7. GMRT HI Observations of the Eridanus Group of Galaxies A. Omar ...

    Indian Academy of Sciences (India)

    The Fornax cluster having the highest galaxy density has the lowest spiral fraction, ... The present GMRT HI observations offer several advantages over studies carried ..... with coarser velocity resolutions for a model galaxy, and determined the ...

  8. New interview and observation measures of the broader autism phenotype : group differentiation

    NARCIS (Netherlands)

    de Jonge, Maretha; Parr, Jeremy; Rutter, Michael; Wallace, Simon; Kemner, Chantal|info:eu-repo/dai/nl/96717041; Bailey, Anthony; van Engeland, Herman; Pickles, Andrew

    To identify the broader autism phenotype (BAP), the Family History Interview subject and informant versions and an observational tool (Impression of Interviewee), were developed. This study investigated whether the instruments differentiated between parents of children with autism, and parents of

  9. New Interview and Observation Measures of the Broader Autism Phenotype : Group Differentiation

    NARCIS (Netherlands)

    de Jonge, Maretha; Parr, Jeremy; Rutter, Michael; Wallace, Simon; Kemner, Chantal; Bailey, Anthony; van Engeland, Herman; Pickles, Andrew

    2015-01-01

    To identify the broader autism phenotype (BAP), the Family History Interview subject and informant versions and an observational tool (Impression of Interviewee), were developed. This study investigated whether the instruments differentiated between parents of children with autism, and parents of

  10. The OMERACT Ultrasound Group: status of current activities and research directions

    DEFF Research Database (Denmark)

    Wakefield, Richard J; D'Agostino, Maria-Antonietta; Iagnocco, Annamaria

    2007-01-01

    Ultrasound (US) is a relatively new imaging modality in rheumatology that offers great potential as a diagnostic and management tool. In 2004, an OMERACT Ultrasound Special Interest Group was formed to address the metric qualities of US as a potential outcome measure. A preliminary systematic...... review highlighted the deficiencies in the literature, particularly with regard to the reliability of interpreting and acquiring images; as a consequence, a number of exercises were proposed to address these issues. This report describes a series of iterative studies that have resulted in improved intra...

  11. Direct observation of glycogen synthesis in human muscle with 13C NMR

    International Nuclear Information System (INIS)

    Jue, T.; Rothman, D.L.; Shulman, G.I.; Tavitian, B.A.; DeFronzo, R.A.; Shulman, R.G.

    1989-01-01

    On the basis of previous indirect measurements, skeletal muscle has been implicated as the major site of glucose uptake and it has been suggested that muscle glycogen formation is the dominant pathway. However, direct measurements of the rates of glycogen synthesis have not been possible by previous techniques. The authors have developed 13 C NMR methods to measure directly the rate of human muscle glycogen formation from infused, isotopically labeled [1- 13 C]glucose. They show that under conditions of imposed hyperglycemia and hyperinsulinemia, a majority of the infused glucose was converted to muscle glycogen in a normal man. This directly shows that muscle is the major site of glucose disposal under these conditions, and provides quantitation of the glucose flux to muscle glycogen

  12. Corneal clarity measurements in healthy volunteers across different age groups: Observational study.

    Science.gov (United States)

    Alzahrani, Khaled; Carley, Fiona; Brahma, Arun; Morley, Debbie; Hillarby, M Chantal

    2017-11-01

    The aim of this study was to standardize and investigate the changes in corneal clarity with age. Densitometry software for the Oculus Pentacam was used to examine corneal clarity at different age groups.A total of 192 eyes from 97 healthy participants were included in this cohort comparative nonrandomized, cross-sectional study. An Oculus Pentcam was used to image the cornea of healthy participants grouped by age (between 10 and 70 years old). Data from the densitometry output have been used to determine clarity in concentric zones and different depths of the cornea.Corneal densitometry (CD) across all ages showed significant differences between groups when divided into the following layers: anterior, central, and posterior or divided into 0 to 2, 2 to 6, and 6 to 10 mm concentric zones (P age in all 3 layers of the periphery (6-10 mm) (P age group had lower clarity than the 20 to 30-age group (P age is differed when the cornea is divided into layers and zones. This study suggests that there are other factors that may play an essential role in corneal clarity as well as age.

  13. Inter-rater reliability of direct observations of the physical and psychosocial working conditions in eldercare

    DEFF Research Database (Denmark)

    Karstad, Kristina; Rugulies, Reiner; Skotte, Jørgen

    2018-01-01

    The aim of the study was to develop and evaluate the reliability of the "Danish observational study of eldercare work and musculoskeletal disorders" (DOSES) observation instrument to assess physical and psychosocial risk factors for musculoskeletal disorders (MSD) in eldercare work. During 1...... is appropriate for assessing physical and psychosocial risk factors for MSD among eldercare workers....

  14. The Effects of Staff Training on the Types of Interactions Observed at Two Group Homes for Foster Care Children

    Science.gov (United States)

    Crosland, Kimberly A.; Dunlap, Glen; Sager, Wayne; Neff, Bryon; Wilcox, Catherine; Blanco, Alfredo; Giddings, Tamela

    2008-01-01

    Objectives: An extensive literature base exists for behavioral parent training; however, few studies have focused on training direct care staff at group home and residential facilities for children. This study was conducted to determine whether a behavioral staff training program consisting of classroom training and in-home feedback would improve…

  15. Direct observation of interfacial C60 cluster formation in polystyrene-C60 nanocomposite films

    International Nuclear Information System (INIS)

    Han, Joong Tark; Lee, Geon-Woong; Kim, Sangcheol; Lee, Hae-Jeong; Douglas, Jack F; Karim, Alamgir

    2009-01-01

    Large interfacial C 60 clusters were directly imaged at the supporting film-substrate interface in physically detached polystyrene-C 60 nanocomposite films by atomic force microscopy, confirming the stabilizing mechanism previously hypothesized for thin polymer films. Additionally, we found that the C 60 additive influences basic thermodynamic film properties such as the interfacial energy and the film thermal expansion coefficient.

  16. Direct observations of the MOF (UiO-66) structure by transmission electron microscopy

    KAUST Repository

    Zhu, Liangkui

    2013-01-01

    As a demonstration of ab initio structure characterizations of nano metal organic framework (MOF) crystals by high resolution transmission electron microscopy (HRTEM) and electron diffraction tomography methods, a Zr-MOF (UiO-66) structure was determined and further confirmed by Rietveld refinements of powder X-ray diffraction. HRTEM gave direct imaging of the channels. © 2013 The Royal Society of Chemistry.

  17. Comparison between AGC and a tuningless LFC approach based on direct observation of DERs

    DEFF Research Database (Denmark)

    Prostejovsky, Alexander Maria; Marinelli, Mattia

    2017-01-01

    , and the resulting reduction of available inertia. In this paper, we propose a tuningless Load-Frequency Control (LFC) approach able to cope with the changing dynamics of electric power grids. Harnessing the possibilities of modern monitoring and communication means, the so-called Direct Load-Frequency Control (DLFC...

  18. Associations of group level popularity with observed behavior and influence in a dyadic context

    NARCIS (Netherlands)

    Lansu, T.A.M.; Cillessen, A.H.N.

    2015-01-01

    This study examined the association between popularity in the peer group and adolescents' behavior in a dyadic context. After collecting peer nominations for popularity, 218 early adolescents (Mage=11.0years) in 109 randomly composed same-sex dyads participated in a discussion task where they

  19. Stakeholders inverted question mark contributions to tailored implementation programs: an observational study of group interview methods

    NARCIS (Netherlands)

    Huntink, E.; Lieshout, J. van; Aakhus, E.; Baker, R.; Flottorp, S.; Godycki-Cwirko, M.; Jager, C.; Kowalczyk, A.; Szecsenyi, J.; Wensing, M.

    2014-01-01

    BackgroundTailored strategies to implement evidence-based practice can be generated in several ways. In this study, we explored the usefulness of group interviews for generating these strategies, focused on improving healthcare for patients with chronic diseases.MethodsParticipants included at least

  20. Measuring Medical Housestaff Teamwork Performance Using Multiple Direct Observation Instruments: Comparing Apples and Apples.

    Science.gov (United States)

    Weingart, Saul N; Yaghi, Omar; Wetherell, Matthew; Sweeney, Megan

    2018-04-10

    To examine the composition and concordance of existing instruments used to assess medical teams' performance. A trained observer joined 20 internal medicine housestaff teams for morning work rounds at Tufts Medical Center, a 415-bed Boston teaching hospital, from October through December 2015. The observer rated each team's performance using 9 teamwork observation instruments that examined domains including team structure, leadership, situation monitoring, mutual support, and communication. Observations recorded on paper forms were stored electronically. Scores were normalized from 1 (low) to 5 (high) to account for different rating scales. Overall mean scores were calculated and graphed; weighted scores adjusted for the number of items in each teamwork domain. Teamwork scores were analyzed using t-tests, pair-wise correlations, and the Kruskal-Wallis statistic, and team performance was compared across instruments by domain. The 9 tools incorporated 5 major domains, with 5-35 items per instrument for a total of 161 items per observation session. In weighted and unweighted analyses, the overall teamwork performance score for a given team on a given day varied by instrument. While all of the tools identified the same low outlier, high performers on some instruments were low performers on others. Inconsistent scores for a given team across instruments persisted in domain-level analyses. There was substantial variation in the rating of individual teams assessed concurrently by a single observer using multiple instruments. Since existing teamwork observation tools do not yield concordant assessments, researchers should create better tools for measuring teamwork performance.

  1. Pseudophakodonesis and corneal endothelial contact: direct observations by high-speed cinematography.

    Science.gov (United States)

    Jacobs, P M; Cheng, H; Price, N C

    1983-10-01

    High-speed cinematography was used to observe the movement of Federov type I lens implants within the anterior chamber. Our measurements suggest that in most patients contact between the lens implant and corneal endothelium does not occur.

  2. Five Methods to Score the Teacher Observation of Classroom Adaptation Checklist and to Examine Group Differences

    Science.gov (United States)

    Wang, Ze; Rohrer, David; Chuang, Chi-ching; Fujiki, Mayo; Herman, Keith; Reinke, Wendy

    2015-01-01

    This study compared 5 scoring methods in terms of their statistical assumptions. They were then used to score the Teacher Observation of Classroom Adaptation Checklist, a measure consisting of 3 subscales and 21 Likert-type items. The 5 methods used were (a) sum/average scores of items, (b) latent factor scores with continuous indicators, (c)…

  3. New Interview and Observation Measures of the Broader Autism Phenotype: Group Differentiation

    Science.gov (United States)

    de Jonge, Maretha; Parr, Jeremy; Rutter, Michael; Wallace, Simon; Kemner, Chantal; Bailey, Anthony; van Engeland, Herman; Pickles, Andrew

    2015-01-01

    To identify the broader autism phenotype (BAP), the Family History Interview subject and informant versions and an observational tool (Impression of Interviewee), were developed. This study investigated whether the instruments differentiated between parents of children with autism, and parents of children with Down syndrome (DS). The BAP scores of…

  4. Effects of observing and producing deictic gestures on memory and learning in different age groups

    NARCIS (Netherlands)

    K.H.R. Ouwehand (Kim)

    2016-01-01

    markdownabstractThe studies presented in this dissertation aimed to investigate whether observing or producing deictic gestures (i.e., pointing and tracing gestures to index a referent in space or a movement pathway), could facilitate memory and learning in children, young adults, and older adults.

  5. Direct observation of strong localization of quasi-two-dimensional light waves

    DEFF Research Database (Denmark)

    Bozhevolnyi, Sergey I.

    1999-01-01

    Scattering of surface plasmon polaritons on rough metal surfaces is investigated by using scanning near-field optical microscopy. Different scattering regimes, i.e. single, double and multiple scattering, are observed and related to the spatial Fourier spectra of the corresponding near-field opti...... caused by surface roughness. Similar bright light spots are observed with light scattering by silver colloid clusters deposited on glass substrates. Differences and similarities in these scattering phenomena are discussed....

  6. Local Group dSph radio survey with ATCA (I): observations and background sources

    Science.gov (United States)

    Regis, Marco; Richter, Laura; Colafrancesco, Sergio; Massardi, Marcella; de Blok, W. J. G.; Profumo, Stefano; Orford, Nicola

    2015-04-01

    Dwarf spheroidal (dSph) galaxies are key objects in near-field cosmology, especially in connection to the study of galaxy formation and evolution at small scales. In addition, dSphs are optimal targets to investigate the nature of dark matter. However, while we begin to have deep optical photometric observations of the stellar population in these objects, little is known so far about their diffuse emission at any observing frequency, and hence on thermal and non-thermal plasma possibly residing within dSphs. In this paper, we present deep radio observations of six local dSphs performed with the Australia Telescope Compact Array (ATCA) at 16 cm wavelength. We mosaicked a region of radius of about 1 deg around three `classical' dSphs, Carina, Fornax, and Sculptor, and of about half of degree around three `ultrafaint' dSphs, BootesII, Segue2, and Hercules. The rms noise level is below 0.05 mJy for all the maps. The restoring beams full width at half-maximum ranged from 4.2 arcsec × 2.5 arcsec to 30.0 arcsec × 2.1 arcsec in the most elongated case. A catalogue including the 1392 sources detected in the six dSph fields is reported. The main properties of the background sources are discussed, with positions and fluxes of brightest objects compared with the FIRST, NVSS, and SUMSS observations of the same fields. The observed population of radio emitters in these fields is dominated by synchrotron sources. We compute the associated source number counts at 2 GHz down to fluxes of 0.25 mJy, which prove to be in agreement with AGN count models.

  7. Anna Freud: the Hampstead War Nurseries and the role of the direct observation of children for psychoanalysis.

    Science.gov (United States)

    Midgley, Nick

    2007-08-01

    The psychoanalytic tradition of direct observation of children has a long history, going back to the early 20th century, when psychoanalysis and the emerging field of 'child studies' came into fruitful contact in Freud's Vienna. As a leading figure in the attempted integration of direct observation with the new psychoanalytic knowledge emerging from the consulting room, Anna Freud played a crucial role in the emergence of this field. But her major contribution to the theory and practice of observing children came during the Second World War, when she founded the Hampstead War Nurseries. The author describes in detail this important period of Anna Freud's career, and discusses the impact it had on later work. He explores the theoretical contribution that Anna Freud made in the post-war years to the debate about the place of direct observation in psychoanalysis, and concludes that Anna Freud's 'double approach' (direct observation plus analytic reconstruction) still has a great deal to offer as a method of both psychoanalytic research and education.

  8. Working Group 2: Future Directions for Safeguards and Verification, Technology, Research and Development

    International Nuclear Information System (INIS)

    Zykov, S.; Blair, D.

    2013-01-01

    For traditional safeguards it was recognized that the hardware presently available is, in general, addressing adequately fundamental IAEA needs, and that further developments should therefore focus mainly on improving efficiencies (i.e. increasing cost economies, reliability, maintainability and user-friendliness, keeping abreast of continual advancements in technologies and of the evolution of verification approaches). Specific technology areas that could benefit from further development include: -) Non-destructive measurement systems (NDA), in particular, gamma-spectroscopy and neutron counting techniques; -) Containment and surveillance tools, such as tamper indicating seals, video-surveillance, surface identification methods, etc.; -) Geophysical methods for design information verification (DIV) and safeguarding of geological repositories; and -) New tools and methods for real-time monitoring. Furthermore, the Working Group acknowledged that a 'building block' (or modular) approach should be adopted towards technology development, enabling equipment to be upgraded efficiently as technologies advance. Concerning non-traditional safeguards, in the area of satellite-based sensors, increased spatial resolution and broadened spectral range were identified as priorities. In the area of wide area surveillance, the development of LIDAR-like tools for atmospheric sensing was discussed from the perspective of both potential benefits and certain limitations. Recognizing the limitations imposed by the human brain in terms of information assessment and analysis, technologies are needed that will enable the more effective utilization of all information, regardless of its format and origin. The paper is followed by the slides of the presentation. (A.C.)

  9. Trace element similarity groups in north Florida Spanish moss: evidence for direct uptake of aerosol particles

    Energy Technology Data Exchange (ETDEWEB)

    Sheline, J.; Akselsson, R.; Winchester, J.W.

    1976-02-20

    The elemental composition of 10 samples of Spanish moss Tillandsia usneoides L. collected mainly in forested areas near Tallahassee, Florida, has been compared to the composition of the ambient aerosol particle background in the forest measured as a function of particle size. For forest samples, moss composition is similar to the composition of aerosol particles greater than about 0.5-..mu..m diameter for the elements S, Cl, Ti, V, Fe, Ni, Zn, Br, Pb, and possibly Cu. Elements relatively enriched in the moss fall into two groups, K, Rb, Zr and Ca, Sr, Mn, based on detailed association patterns. No evidence is found for an enrichment, relative to the ambient aerosol, of pollution-derived elements Pb, Br, V, and Ni, although those elements are found at higher concentrations in moss samples from locations nearer roadways or oil-fired power plants. The moss appears to have potential value as an indicator of time average aerosol composition for particles of greater than or equal to 0.5 ..mu..m, except for the enriched elements, which may have longer biological retention times. (auth)

  10. A Hydrazone-Based exo-Directing-Group Strategy for β C-H Oxidation of Aliphatic Amines.

    Science.gov (United States)

    Huang, Zhongxing; Wang, Chengpeng; Dong, Guangbin

    2016-04-18

    Described is a new hydrazone-based exo-directing group (DG) strategy developed for the functionalization of unactivated primary β C-H bonds of aliphatic amines. Conveniently synthesized from protected primary amines, the hydrazone DGs are shown to site-selectively promote the β-acetoxylation and tosyloxylation via five-membered exo-palladacycles. Amines with a wide scope of skeletons and functional groups are tolerated. Moreover, the hydrazone DG can be readily removed, and a one-pot C-H acetoxylation/DG removal protocol was also discovered. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. DIRECT OBSERVATION OF THE TURBULENT emf AND TRANSPORT OF MAGNETIC FIELD IN A LIQUID SODIUM EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    Rahbarnia, Kian; Brown, Benjamin P.; Clark, Mike M.; Kaplan, Elliot J.; Nornberg, Mark D.; Rasmus, Alex M.; Taylor, Nicholas Zane; Forest, Cary B. [Department of Physics, University of Wisconsin-Madison, 1150 University Ave, Madison, WI 53706 (United States); Jenko, Frank; Limone, Angelo [Max-Planck-Institut fuer Plasmaphysik (IPP), EURATOM Association, D-85748 Garching (Germany); Pinton, Jean-Francois; Plihon, Nicolas; Verhille, Gautier, E-mail: kian.rahbarnia@ipp.mpg.de [Laboratoire de Physique de l' Ecole Normale Superieure de Lyon, CNRS and Universite de Lyon, F-69364 Lyon (France)

    2012-11-10

    For the first time, we have directly measured the transport of a vector magnetic field by isotropic turbulence in a high Reynolds number liquid metal flow. In analogy with direct measurements of the turbulent Reynolds stress (turbulent viscosity) that governs momentum transport, we have measured the turbulent electromotive force (emf) by simultaneously measuring three components of velocity and magnetic fields, and computed the correlations that lead to mean-field current generation. Furthermore, we show that this turbulent emf tends to oppose and cancel out the local current, acting to increase the effective resistivity of the medium, i.e., it acts as an enhanced magnetic diffusivity. This has important implications for turbulent transport in astrophysical objects, particularly in dynamos and accretion disks.

  12. Barkhausen noise measurements give direct observation of magnetocrystalline anisotropy energy in ferromagnetic polycrystals

    International Nuclear Information System (INIS)

    Espina-Hernández, J H; Pérez-Benítez, J A; Caleyo, F; Hallen, J M; Baudin, T; Helbert, A L

    2013-01-01

    This paper presents experimental evidence of the capability of Barkhausen noise measurements to estimate the angular dependence of the average magnetocrystalline energy in soft magnetic polycrystalline materials. Three different API 5L steel samples, all obtained from out-of-service pipelines, were investigated using crystallographic texture and Barkhausen noise measurements. The angular dependence of the rms voltage of the Barkhausen signal was determined in each sample for the time band corresponding to the saturation-to-remanence part of the hysteresis loop where irreversible domain rotation occurs. For each angular position, the rms voltage of the Barkhausen noise signal in this time band was interpreted as a direct measure of the magnetocrystalline anisotropy energy of the polycrystal in the corresponding direction. A strong correlation between the angular dependence of both the rms voltage of the Barkhausen signal in the time band of interest and the average magnetocrystalline energy obtained from crystallographic texture measurements was found experimentally. (fast track communication)

  13. DIRECT OBSERVATION OF THE TURBULENT emf AND TRANSPORT OF MAGNETIC FIELD IN A LIQUID SODIUM EXPERIMENT

    International Nuclear Information System (INIS)

    Rahbarnia, Kian; Brown, Benjamin P.; Clark, Mike M.; Kaplan, Elliot J.; Nornberg, Mark D.; Rasmus, Alex M.; Taylor, Nicholas Zane; Forest, Cary B.; Jenko, Frank; Limone, Angelo; Pinton, Jean-François; Plihon, Nicolas; Verhille, Gautier

    2012-01-01

    For the first time, we have directly measured the transport of a vector magnetic field by isotropic turbulence in a high Reynolds number liquid metal flow. In analogy with direct measurements of the turbulent Reynolds stress (turbulent viscosity) that governs momentum transport, we have measured the turbulent electromotive force (emf) by simultaneously measuring three components of velocity and magnetic fields, and computed the correlations that lead to mean-field current generation. Furthermore, we show that this turbulent emf tends to oppose and cancel out the local current, acting to increase the effective resistivity of the medium, i.e., it acts as an enhanced magnetic diffusivity. This has important implications for turbulent transport in astrophysical objects, particularly in dynamos and accretion disks.

  14. Direct observation of deformation of nafion surfaces induced by methanol treatment by using atomic force microscopy

    International Nuclear Information System (INIS)

    Umemura, Kazuo; Kuroda, Reiko; Gao Yanfeng; Nagai, Masayuki; Maeda, Yuta

    2008-01-01

    We successfully characterized the effect of methanol treatment on the nanoscopic structures of a nafion film, which is widely used in direct methanol fuel cells (DMFCs). Atomic force microscopy (AFM) was used to repetitively image a particular region of a nafion sample before and after methanol solutions were dropped onto the nafion film and dried in air. When the surface was treated with 20% methanol for 5 min, many nanopores appeared on the surface. The number of nanopores increased when the sample was treated twice or thrice. By repetitive AFM imaging of a particular region of the same sample, we found that the shapes of the nanopores were deformed by the repeated methanol treatment, although the size of the nanopores had not significantly changed. The creation of the nanopores was affected by the concentration of methanol. Our results directly visualized the effects of methanol treatment on the surface structures of a nafion film at nanoscale levels for the first time

  15. Direct Observation of Field and Temperature Induced Domain Replication in Dipolar Coupled Perpendicular Anisotropy Films

    Energy Technology Data Exchange (ETDEWEB)

    Hauet, T.; Gunther, C.M.; Pfau, B.; Eisebitt, S.; Fischer, P.; Rick, R. L.; Thiele, J.-U.; Hellwig, O.; Schabes, M.E.

    2007-07-01

    Dipolar interactions in a soft/Pd/hard [CoNi/Pd]{sub 30}/Pd/[Co/Pd]{sub 20} multilayer system, where a thick Pd layer between two ferromagnetic units prevents direct exchange coupling, are directly revealed by combining magnetometry and state-of-the-art layer resolving soft x-ray imaging techniques with sub-100-nm spatial resolution. The domains forming in the soft layer during external magnetic field reversal are found to match the domains previously trapped in the hard layer. The low Curie temperature of the soft layer allows varying its intrinsic parameters via temperature and thus studying the competition with dipolar fields due to the domains in the hard layer. Micromagnetic simulations elucidate the role of [CoNi/Pd] magnetization, exchange, and anisotropy in the duplication process. Finally, thermally driven domain replication in remanence during temperature cycling is demonstrated.

  16. Direct observation of the transition from free to constrained single segment motion in entangled polymer melts

    International Nuclear Information System (INIS)

    Monkenbusch, M.; Wischnewski, A.; Willner, L.; Richter, D.

    2004-01-01

    Incoherent neutron-spin-echo spectroscopy (NSE) has been employed to directly determine the time-dependent mean-squared segment displacement 2 > of a polymer chain in the melt covering the transition from free to constraint Rouse relaxation along the virtual tube of the reptation model. The predicted transition of the time dependence of 2 > from 2 >∝t 1/2 to ∝t 1/4 is clearly corroborated by the incoherent NSE results

  17. Some observations concerning the direct titration of nitrite with cerium(IV)

    International Nuclear Information System (INIS)

    Muralikrishna, U.; Subrahmanyam, K.; Suryanarayana, M.V.S.; Krishnamurthy, M.

    1983-01-01

    Direct titration of nitrite with cerium(IV), with ferroin as indicator, is shown to give satisfactory results if the acidity is kept between 0.033 and 0.055 M at the end-point. Loss of nitrous acid owing to volatilization and decomposition is discussed. From 10 to 60 mg of sodium nitrite can be estimated with a standard deviation of 5 μg and an average error of 0.2%. (author)

  18. Direct Observations of ULF and Whistler-Mode Chorus Modulation of 500eV EDI Electrons by MMS

    Science.gov (United States)

    Paulson, K. W.; Argall, M. R.; Ahmadi, N.; Torbert, R. B.; Le Contel, O.; Ergun, R.; Khotyaintsev, Y. V.; Strangeway, R. J.; Magnes, W.; Russell, C. T.

    2016-12-01

    We present here direct observations of chorus-wave modulated field-aligned 500 eV electrons using the Electron Drift Instrument (EDI) on board the Magnetospheric Multiscale mission. These periods of wave activity were additionally observed to be modulated by Pc5-frequency magnetic perturbations, some of which have been identified as drifting mirror-mode structures. The spacecraft encountered these mirror-mode structures just inside of the duskside magnetopause. Using the high sampling rate provided by EDI in burst sampling mode, we are able to observe the individual count fluctuations of field-aligned electrons in this region up to 512 Hz. We use the multiple look directions of EDI to generate both pitch angle and gyrophase plots of the fluctuating counts. Our observations often show unidirectional flow of these modulated electrons along the background field, and in some cases demonstrate gyrophase bunching in the wave region.

  19. The novel programmable riometer for in-depth ionospheric and magnetospheric observations (PRIAMOS) using direct sampling DSP techniques

    OpenAIRE

    Dekoulis, G.; Honary, F.

    2005-01-01

    This paper describes the feasibility study and simulation results for the unique multi-frequency, multi-bandwidth, Programmable Riometer for in-depth Ionospheric And Magnetospheric ObservationS (PRIAMOS) based on direct sampling digital signal processing (DSP) techniques. This novel architecture is based on sampling the cosmic noise wavefront at the antenna. It eliminates the usage of any intermediate frequency (IF) mixer stages (-6 dB) and the noise balancing technique (-3 dB), providing a m...

  20. Electronic monitoring in combination with direct observation as a means to significantly improve hand hygiene compliance.

    Science.gov (United States)

    Boyce, John M

    2017-05-01

    Monitoring hand hygiene compliance among health care personnel (HCP) is an essential element of hand hygiene promotion programs. Observation by trained auditors is considered the gold standard method for establishing hand hygiene compliance rates. Advantages of observational surveys include the unique ability to establish compliance with all of the World Health Organization "My 5 Moments for Hand Hygiene" initiative Moments and to provide just-in-time coaching. Disadvantages include the resources required for observational surveys, insufficient sample sizes, and nonstandardized methods of conducting observations. Electronic and camera-based systems can monitor hand hygiene performance on all work shifts without a Hawthorne effect and provide significantly more data regarding hand hygiene performance. Disadvantages include the cost of installation, variable accuracy in estimating compliance rates, issues related to acceptance by HCP, insufficient data regarding their cost-effectiveness and influence on health care-related infection rates, and the ability of most systems to monitor only surrogates for Moments 1, 4, and 5. Increasing evidence suggests that monitoring only Moments 1, 4, and 5 provides reasonable estimates of compliance with all 5 Moments. With continued improvement of electronic monitoring systems, combining electronic monitoring with observational methods may provide the best information as part of a multimodal strategy to improve and sustain hand hygiene compliance rates among HCP. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  1. Children's Physical Activity While Gardening: Development of a Valid and Reliable Direct Observation Tool.

    Science.gov (United States)

    Myers, Beth M; Wells, Nancy M

    2015-04-01

    Gardens are a promising intervention to promote physical activity (PA) and foster health. However, because of the unique characteristics of gardening, no extant tool can capture PA, postures, and motions that take place in a garden. The Physical Activity Research and Assessment tool for Garden Observation (PARAGON) was developed to assess children's PA levels, tasks, postures, and motions, associations, and interactions while gardening. PARAGON uses momentary time sampling in which a trained observer watches a focal child for 15 seconds and then records behavior for 15 seconds. Sixty-five children (38 girls, 27 boys) at 4 elementary schools in New York State were observed over 8 days. During the observation, children simultaneously wore Actigraph GT3X+ accelerometers. The overall interrater reliability was 88% agreement, and Ebel was .97. Percent agreement values for activity level (93%), garden tasks (93%), motions (80%), associations (95%), and interactions (91%) also met acceptable criteria. Validity was established by previously validated PA codes and by expected convergent validity with accelerometry. PARAGON is a valid and reliable observation tool for assessing children's PA in the context of gardening.

  2. Effects of observing and producing deictic gestures on memory and learning in different age groups

    OpenAIRE

    Ouwehand, Kim

    2016-01-01

    markdownabstractThe studies presented in this dissertation aimed to investigate whether observing or producing deictic gestures (i.e., pointing and tracing gestures to index a referent in space or a movement pathway), could facilitate memory and learning in children, young adults, and older adults. More specifically, regarding memory it was investigated whether the use of deictic gestures would improve performance on tasks targeting cognitive functions that are found to change with age (worki...

  3. Let another praise you? The effects of source and attributional content on responses to group-directed praise.

    Science.gov (United States)

    Rabinovich, Anna; Morton, Thomas A; Crook, Michael; Travers, Claire

    2012-12-01

    Not all types of praise may be equally stimulating. Instead, positive feedback carries different meaning depending on the source that delivers it and the attributions for success that it contains. In the present study, source (in-group vs. out-group) of praise and its content (attributing success to internal vs. external causes) were experimentally manipulated. The results revealed that there was a significant interaction between source and content of praise on performance in a praise-related task. As predicted, participants exposed to out-group praise were motivated by external attributions for success rather than by internal attributions. Conversely, when praise originated from an in-group source, the attributional content of praise did not affect performance. This effect of source and content of praise on relevant behaviour was mediated by willingness to protect group image. Thus, responses to praise are contingent on what it implies about group success--corresponding to patterns demonstrated in previous work on group-directed criticism. ©2012 The British Psychological Society.

  4. Direct observation of magnetization reversal of hot-deformed Nd-Fe-B magnet

    Science.gov (United States)

    Zhu, Xiaoyun; Tang, Xu; Pei, Ke; Tian, Yue; Liu, Jinjun; Xia, Weixing; Zhang, Jian; Liu, J. Ping; Chen, Renjie; Yan, Aru

    2018-01-01

    The dynamic magnetic domain structure in magnetization and demagnetization process of hot-deformed and NdCu-diffused Nd2Fe14B magnets were in-situ observed by Lorentz transmission electron microscopy (LTEM). The demagnetization process of hot-deformed sample is dominated by domain-wall pinning, while that of NdCu-diffused sample is mainly the magnetization reversal of single grains or grain aggregations. This firstly observed result gives an explicit evidence to understand the coercivity mechanism of magnetically segregated magnet. The effect of magnetic field of TEM on decrease in domain wall energy was theoretically analyzed, which helps to understand the in-situ observation process of magnetic materials.

  5. Direct observation of magnetization reversal of hot-deformed Nd-Fe-B magnet

    Directory of Open Access Journals (Sweden)

    Xiaoyun Zhu

    2018-01-01

    Full Text Available The dynamic magnetic domain structure in magnetization and demagnetization process of hot-deformed and NdCu-diffused Nd2Fe14B magnets were in-situ observed by Lorentz transmission electron microscopy (LTEM. The demagnetization process of hot-deformed sample is dominated by domain-wall pinning, while that of NdCu-diffused sample is mainly the magnetization reversal of single grains or grain aggregations. This firstly observed result gives an explicit evidence to understand the coercivity mechanism of magnetically segregated magnet. The effect of magnetic field of TEM on decrease in domain wall energy was theoretically analyzed, which helps to understand the in-situ observation process of magnetic materials.

  6. Direct observations of low-energy solar electrons associated with a type 3 solar radio burst

    Science.gov (United States)

    Frank, L. A.; Gurnett, D. A.

    1972-01-01

    On 6 April 1971 a solar X-ray flare and a type 3 solar radio noise burst were observed with instrumentation on the eccentric-orbiting satellite IMP 6. The type 3 solar radio noise burst was detected down to a frequency of 31 kHz. A highly anisotropic packet of low-energy solar electron intensities arrived at the satellite approximately 6000 seconds after the onset of the solar flare. This packet of solar electron intensities was observed for 4200 seconds. Maximum differential intensities of the solar electrons were in the energy range of one to several keV. The frequency drift rate of the type 3 radio noise at frequencies below 178 kHz also indicated an average particle speed corresponding to that of a 3-keV electron. The simultaneous observations of these solar electron intensities and of the type 3 solar radio burst are presented, and their interrelationships are explored.

  7. Paradise Lost: Some Observations Directed Toward the Bi-centennial of the U.S.

    Science.gov (United States)

    O'Dell, J. H.

    1975-01-01

    An examination of some of the historical forces and internal contradictions shaping the features of the present crisis of 20th century America, which points toward the necessity of resolving the central problems created by a capitalist, monopolist society and the need for genuine liberation of the poor and minority groups. (EH)

  8. ALMA observations of molecular absorption in four directions toward the Galactic bulge

    Science.gov (United States)

    Liszt, H.; Gerin, M.

    2018-02-01

    Context. Alma Cycle 3 observations serendipitously showed strong absorption from diffuse molecular gas in the Galactic bulge at -200 km s-1 51(3σ) for the bulge gas toward J1744 and 58 ± 9 and 64 ± 4 for the disk gas toward J1717 and J1744, respectively, all well above the value of 20-25 typical of the central molecular zone. Conclusions: The kinematics and chemistry of the bulge gas observed toward J1744 more nearly resemble that of gas in the Milky Way disk than in the central molecular zone.

  9. Unique transcriptomic response to sepsis is observed among patients of different age groups.

    Science.gov (United States)

    Raymond, Steven L; López, María Cecilia; Baker, Henry V; Larson, Shawn D; Efron, Philip A; Sweeney, Timothy E; Khatri, Purvesh; Moldawer, Lyle L; Wynn, James L

    2017-01-01

    Sepsis is a major cause of morbidity and mortality, especially at the extremes of age. To understand the human age-specific transcriptomic response to sepsis, a multi-cohort, pooled analysis was conducted on adults, children, infants, and neonates with and without sepsis. Nine public whole-blood gene expression datasets (636 patients) were employed. Age impacted the transcriptomic host response to sepsis. Gene expression from septic neonates and adults was more dissimilar whereas infants and children were more similar. Neonates showed reductions in inflammatory recognition and signaling pathways compared to all other age groups. Likewise, adults demonstrated decreased pathogen sensing, inflammation, and myeloid cell function, as compared to children. This may help to explain the increased incidence of sepsis-related organ failure and death in adults. The number of dysregulated genes in septic patients was proportional to age and significantly differed among septic adults, children, infants, and neonates. Overall, children manifested a greater transcriptomic intensity to sepsis as compared to the other age groups. The transcriptomic magnitude for adults and neonates was dramatically reduced as compared to children and infants. These findings suggest that the transcriptomic response to sepsis is age-dependent, and diagnostic and therapeutic efforts to identify and treat sepsis will have to consider age as an important variable.

  10. Hand hygiene compliance in transplant and other special patient groups: an observational study.

    Science.gov (United States)

    Graf, Karolin; Ott, Ella; Wolny, Michael; Tramp, Nadine; Vonberg, Ralf-Peter; Haverich, Axel; Chaberny, Iris Freya

    2013-06-01

    This study evaluates hand hygiene behavior of health care workers in a German university hospital stratified for treatment of special patient groups (eg, transplant patients). From 2008 to 2010, comprehensive education and training of all health care workers was implemented to improve hand hygiene compliance. Consumption rates of alcohol-based hand rub and gloves were collected and evaluated. Of the 5,647 opportunities of hand disinfection evaluated, 1,607 occurred during care for transplant patients. To our knowledge, this is the largest survey of hand hygiene compliance in special patient groups on intensive care units in a university hospital in Germany. Health care workers on surgical intensive care units showed lower hand hygiene compliance compared with health care workers on other types of intensive care units. Compliance toward hand hygiene was significantly higher on hemato-oncologic and pediatric wards. In general, hand disinfection was performed significantly more frequently after an intervention than before (P hand hygiene compliance when caring for transplant patients or other patients (odds ratio, 1.16; 95% confidence interval: 0.95-1.42). Nurse's and physician's hand hygiene compliance improved because of education. Hand hygiene compliance is not increased in the care for transplant patients (despite their predisposition for nosocomial infections) compared with other patients. Additional studies will be necessary to further investigate these findings. Copyright © 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

  11. Direct Observation of Dynamical Quantum Phase Transitions in an Interacting Many-Body System.

    Science.gov (United States)

    Jurcevic, P; Shen, H; Hauke, P; Maier, C; Brydges, T; Hempel, C; Lanyon, B P; Heyl, M; Blatt, R; Roos, C F

    2017-08-25

    The theory of phase transitions represents a central concept for the characterization of equilibrium matter. In this work we study experimentally an extension of this theory to the nonequilibrium dynamical regime termed dynamical quantum phase transitions (DQPTs). We investigate and measure DQPTs in a string of ions simulating interacting transverse-field Ising models. During the nonequilibrium dynamics induced by a quantum quench we show for strings of up to 10 ions the direct detection of DQPTs by revealing nonanalytic behavior in time. Moreover, we provide a link between DQPTs and the dynamics of other quantities such as the magnetization, and we establish a connection between DQPTs and entanglement production.

  12. Replication of Non-Trivial Directional Motion in Multi-Scales Observed by the Runs Test

    Science.gov (United States)

    Yura, Yoshihiro; Ohnishi, Takaaki; Yamada, Kenta; Takayasu, Hideki; Takayasu, Misako

    Non-trivial autocorrelation in up-down statistics in financial market price fluctuation is revealed by a multi-scale runs test(Wald-Wolfowitz test). We apply two models, a stochastic price model and dealer model to understand this property. In both approaches we successfully reproduce the non-stationary directional price motions consistent with the runs test by tuning parameters in the models. We find that two types of dealers exist in the markets, a short-time-scale trend-follower and an extended-time-scale contrarian who are active in different time periods.

  13. Direct Observation of Dynamical Quantum Phase Transitions in an Interacting Many-Body System

    Science.gov (United States)

    Jurcevic, P.; Shen, H.; Hauke, P.; Maier, C.; Brydges, T.; Hempel, C.; Lanyon, B. P.; Heyl, M.; Blatt, R.; Roos, C. F.

    2017-08-01

    The theory of phase transitions represents a central concept for the characterization of equilibrium matter. In this work we study experimentally an extension of this theory to the nonequilibrium dynamical regime termed dynamical quantum phase transitions (DQPTs). We investigate and measure DQPTs in a string of ions simulating interacting transverse-field Ising models. During the nonequilibrium dynamics induced by a quantum quench we show for strings of up to 10 ions the direct detection of DQPTs by revealing nonanalytic behavior in time. Moreover, we provide a link between DQPTs and the dynamics of other quantities such as the magnetization, and we establish a connection between DQPTs and entanglement production.

  14. Direct observation of salts as micro-inclusions in the Greenland GRIP ice core

    DEFF Research Database (Denmark)

    Dahl-Jensen, Dorthe; Sakurai, Toshimitsu; Iizuka, Yoshinori

    2009-01-01

    We provide the first direct evidence that a number of water-soluble compounds, in particular calcium sulfate (CaSO4·2H2O) and calcium carbonate (CaCO3), are present as solid, micron-sized inclusions within the Greenland GRIP ice core. The compounds are detected by two independent methods: micro...... distributions of the micro-inclusions. These results suggest that water-soluble aerosols in the GRIP ice core are dependable proxies for past atmospheric conditions. Udgivelsesdato: December...

  15. Direct observations of surface water-groundwater interaction using electrical resistivity tomography

    NARCIS (Netherlands)

    Noell, Ursula; Wießner, Claudia; Ganz, Christina; Westhoff, Martijn

    2011-01-01

    Electrical resistivity tomography is a helpful tool to observe the infiltration process in and through the soil. Array 3-D measurements and 3-D inversion schemes are required for reliable interpretation of heterogeneous subsurface structures. Smoothing of the inversion can be minimized by using

  16. Parent-Child Mathematical Interactions: Examining Self-Report and Direct Observation

    Science.gov (United States)

    Missall, Kristen N.; Hojnoski, Robin L.; Moreano, Ginna

    2017-01-01

    Variability in children's early-learning home environments points to the need to better understand specific mechanisms of early mathematical development. We used a sample of 66 parent-preschool child dyads to describe parent-reported mathematical activities in the home and observed parent-child mathematical activities in a semi-structured play…

  17. Directly Observed Physical Activity among 3-Year-Olds in Finnish Childcare

    Science.gov (United States)

    Soini, Anne; Villberg, Jari; Sääkslahti, Arja; Gubbels, Jessica; Mehtälä, Anette; Kettunen, Tarja; Poskiparta, Marita

    2014-01-01

    The main purpose of the study was to determine 3-year-olds' physical activity levels and how these vary across season, gender, time of day, location, and the physical and social environment in childcare settings in Finland. A modified version of the Observational System for Recording Physical Activity in Children-Preschool (OSRAC-P) was used to…

  18. Pseudophakodonesis and corneal endothelial contact: direct observations by high-speed cinematography.

    Science.gov (United States)

    Jacobs, P M; Cheng, H; Price, N C

    1983-01-01

    High-speed cinematography was used to observe the movement of Federov type I lens implants within the anterior chamber. Our measurements suggest that in most patients contact between the lens implant and corneal endothelium does not occur. Images PMID:6615750

  19. Establishing the Feasibility of Direct Observation in the Assessment of Tics in Children with Chronic Tic Disorders

    Science.gov (United States)

    Himle, Michael B.; Chang, Susanna; Woods, Douglas W.; Pearlman, Amanda; Buzzella, Brian; Bunaciu, Liviu; Piacentini, John C.

    2006-01-01

    Behavior analysis has been at the forefront in establishing effective treatments for children and adults with chronic tic disorders. As is customary in behavior analysis, the efficacy of these treatments has been established using direct-observation assessment methods. Although behavior-analytic treatments have enjoyed acceptance and integration…

  20. Direct and inverse Staebler-Wronski effects observed in carbon-doped hydrogenated amorphous silicon photo-detectors

    International Nuclear Information System (INIS)

    Arce, P.; Barcala, J.M.; Calvo, E.; Ferrando, A.; Josa, M.I.; Molinero, A.; Navarrete, J.; Oller, J.C.; Yuste, C.; Brochero, J.; Calderon, A.; Fernandez, M.G.; Gomez, G.; Gonzalez-Sanchez, F.J.; Martinez-Rivero, C.; Matorras, F.; Rodrigo, T.; Ruiz-Arbol, P.; Scodellaro, L.; Sobron, M.

    2011-01-01

    The photo-response behaviour of Amorphous Silicon Position Detectors (ASPDs) under prolonged illumination with a 681 nm diode-laser and a 633 nm He-Ne laser is presented. Both direct and inverse Staebler-Wronski effects are observed.

  1. Experimental observation of the improvement in MTF from backthinning a CMOS direct electron detector

    International Nuclear Information System (INIS)

    McMullan, G.; Faruqi, A.R.; Henderson, R.; Guerrini, N.; Turchetta, R.; Jacobs, A.; Hoften, G. van

    2009-01-01

    The advantages of backthinning monolithic active pixel sensors (MAPS) based on complementary metal oxide semiconductor (CMOS) direct electron detectors for electron microscopy have been discussed previously; they include better spatial resolution (modulation transfer function or MTF) and efficiency at all spatial frequencies (detective quantum efficiency or DQE). It was suggested that a 'thin' CMOS detector would have the most outstanding properties because of a reduction in the proportion of backscattered electrons. In this paper we show, theoretically (using Monte Carlo simulations of electron trajectories) and experimentally that this is indeed the case. The modulation transfer functions of prototype backthinned CMOS direct electron detectors have been measured at 300 keV. At zero spatial frequency, in non-backthinned 700-μm-thick detectors, the backscattered component makes up over 40% of the total signal but, by backthinning to 100, 50 or 35 μm, this can be reduced to 25%, 15% and 10%, respectively. For the 35 μm backthinned detector, this reduction in backscatter increases the MTF by 40% for spatial frequencies between 0.1 and 1.0 Nyquist. As discussed in the main text, reducing backscattering in backthinned detectors should also improve DQE.

  2. Sunspot number recalibration: The ~1840–1920 anomaly in the observer normalization factors of the group sunspot number

    Directory of Open Access Journals (Sweden)

    Cliver Edward W.

    2017-01-01

    Full Text Available We analyze the normalization factors (k′-factors used to scale secondary observers to the Royal Greenwich Observatory (RGO reference series of the Hoyt & Schatten (1998a, 1998b group sunspot number (GSN. A time series of these k′-factors exhibits an anomaly from 1841 to 1920, viz., the average k′-factor for all observers who began reporting groups from 1841 to 1883 is 1.075 vs. 1.431 for those who began from 1884 to 1920, with a progressive rise, on average, during the latter period. The 1883–1884 break between the two subintervals occurs precisely at the point where Hoyt and Schatten began to use a complex daisy-chaining method to scale observers to RGO. The 1841–1920 anomaly implies, implausibly, that the average sunspot observer who began from 1841 to 1883 was nearly as proficient at counting groups as mid-20th century RGO (for which k′ = 1.0 by definition while observers beginning during the 1884–1920 period regressed in group counting capability relative to those from the earlier interval. Instead, as shown elsewhere and substantiated here, RGO group counts increased relative to those of other long-term observers from 1874 to ~1915. This apparent inhomogeneity in the RGO group count series is primarily responsible for the increase in k′-factors from 1884 to 1920 and the suppression, by 44% on average, of the Hoyt and Schatten GSN relative to the original Wolf sunspot number (WSN before ~1885. Correcting for the early “learning curve” in the RGO reference series and minimizing the use of daisy-chaining rectifies the anomalous behavior of the k′-factor series. The resultant GSN time series (designated GSN* is in reasonable agreement with the revised WSN (SN*; Clette & Lefèvre 2016 and the backbone-based group sunspot number (RGS; Svalgaard & Schatten 2016 but significantly higher than other recent reconstructions (Friedli, personal communication, 2016; Lockwood et al. 2014a, 2014b; Usoskin et al. 2016a. This result

  3. Influenza C virus high seroprevalence rates observed in 3 different population groups.

    Science.gov (United States)

    Salez, Nicolas; Mélade, Julien; Pascalis, Hervé; Aherfi, Sarah; Dellagi, Koussay; Charrel, Rémi N; Carrat, Fabrice; de Lamballerie, Xavier

    2014-08-01

    The epidemiology of Influenza C virus (FLUCV) infections remains poorly characterised. Here, we have examined the age- and location-specific seroprevalence of antibodies against FLUCV in 1441 sera from metropolitan continental France (Marseille), South-West Indian Ocean French territories (Reunion Island) and United-Kingdom (Edinburgh) using a combination of haemagglutination inhibition, virus neutralisation and ELISA assays. Our results show that immunity to FLUCV is common in all locations studied (global seroprevalence values >50%) and that the first immunising contacts generally occur early in life (i.e., in the 0-4 year-old age group). The latter item is further supported by the detection of FLUCV RNA by RT-PCR in naso-pharyngeal samples collected in patient attending the Emergency Room of the Public hospitals of Marseille, France with a large majority of children under 10 years-old: 17 (60.7%) in children ≤3 yo, 10 (35.7%) in the 4-10 yo age group and 1 (3.6%) in an adult (49yo). The temporal distribution of cases was atypical with regard to influenza (a large proportion of cases occurred in spring and summer) and the clinical presentation was diverse, including but being not limited to classical Influenza-like-Ilnesses. Altogether, our results indicate an intense circulation of FLUCV in the different study areas and an early occurrence of infection in human life. Flu C appears to be a widely under-diagnosed and under-studied human paediatric disease that obviously deserves further clinical and epidemiological characterisation. Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  4. Association of anxiety and depression with hypertension control: a US multidisciplinary group practice observational study.

    Science.gov (United States)

    Ho, Aaron K; Thorpe, Carolyn T; Pandhi, Nancy; Palta, Mari; Smith, Maureen A; Johnson, Heather M

    2015-11-01

    The presence of a mental health disorder with hypertension is associated with higher cardiovascular disease mortality than hypertension alone. Although earlier detection of hypertension has been demonstrated in patients with anxiety and depression, the relationship of mental health disorders to hypertension control is unknown. Our objective was to evaluate rates and predictors of incident hypertension control among patients with anxiety and/or depression compared with patients without either mental health diagnosis. A 4-year retrospective analysis included 4362 patients, at least 18 years old, who received primary care in a large academic group practice from 2008 to 2011. Patients met The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure criteria and had a hypertension diagnosis. Kaplan-Meier analysis estimated the probability of achieving control for patients with and without anxiety and/or depression. Cox proportional hazard models were fit to identify predictors of time to control. Overall, 13% (n = 573) had a baseline diagnosis of anxiety and/or depression. Those with anxiety and/or depression demonstrated more primary care and specialty visits than those without either condition. After adjustment, patients with anxiety and/or depression had faster rates of hypertension control (hazard ratio [HR] 1.22; 1.07-1.39] than patients without either diagnosis. Other associations of faster hypertension control included female gender (HR 1.32; 1.20-1.44), absence of tobacco use (HR 1.17; 1.03-1.33), Medicaid use (HR 1.27; 1.09-1.49), and a higher Adjusted Clinical Group Risk Score (HR 1.13; 1.10-1.17), a measure of healthcare utilization. Greater healthcare utilization among patients with anxiety and/or depression may contribute to faster hypertension control.

  5. Direct spectroscopic observation of charge-exchange recombination of medium-Z elements in the PLT tokamak

    International Nuclear Information System (INIS)

    Skinner, C.H.; Suckewer, S.; Cohen, S.A.; Schilling, G.; Wilson, R.; Stratton, B.

    1984-03-01

    We report the first observation of line emission resulting directly from charge-exchange recombination of medium-Z elements (Al, Sc) injected into a PLT discharge. Transitions due to the radiative cascade immediately following charge-exchange of He-like Al and Sc were observed by a VUV spectrograph and two air monochromators. In two cases, AlXI 3209 A and ScXIX 112.1 A, the observed transition had not previously been experimentally identified. Spatial scans provided information on the profile of the neutral beam in the plasma

  6. Direct observation of the decay of beauty particles into charm particles

    Energy Technology Data Exchange (ETDEWEB)

    Albanese, J P; Alpe, V; Aoki, S; Arnold, R; Baroni, G; Barth, M; Bartley, J H; Bertrand, D; Bertrand-Coremans, G; Bisi, V [Aichi Univ. of Education, Kariya (Japan); Aichi Women' s Coll, Nisshin-Cho [Japan; Bari Univ. (Italy). Ist. di Fisica; Istituto Nazionale di Fisica Nucleare, Bari (Italy); Birkbeck Coll, London [UK; Interuniversity Inst. for High Energies, Brussels (Belgium); European Organization for Nuclear Research, Geneva (Switzerland); University Coll., Dublin (Ireland); Gifu Univ. (Japan). Faculty of Education; University Coll., London (UK); Nagoya Univ. (Japan). Dept. of Physics; Nagoya Inst. of Tech. (Japan); Rome Univ. (Italy). Ist. di Fisica; Istituto Nazionale di Fisica Nucleare, Rome (Italy); Toho Univ., Funabashi, Chiba (Japan). Faculty of Science; Istituto Nazionale di Fisica Nucleare, Turin (Italy); Turin Univ. (Italy). Ist. di Fisica; Utsunomiya Univ. (Japan). Faculty of Education; Yokohama National Univ. (Japan). Faculty of Education

    1985-08-08

    The associated production of a pair of beauty particles B/sup -/ and anti B/sup 0/ by a 350 GeV ..pi../sup -/ interaction has been observed in an emulsion target inserted in an array of silicon microstrip detectors. Both beauty particles decay into charm particles, both of which are also observed to decay in the emulsion. Two negative muons were identified and their momenta measured in a large muon spectrometer. One muon has a psub(T) of 1.9 GeV/c and is associated with a beauty particle decay. The other, with a psub(T) of 0.45 GeV/c is associated with a charm particle decay. The flight times of the two beauty particles are respectively (0.8 +- 0.1).10/sup -13/s and (5sub(-1)/sup +2/).10/sup -13/s. Alternative interpretations of this event have negligible probability.

  7. Direct in situ observations of single Fe atom catalytic processes and anomalous diffusion at graphene edges

    Science.gov (United States)

    Zhao, Jiong; Deng, Qingming; Avdoshenko, Stanislav M.; Fu, Lei; Eckert, Jürgen; Rümmeli, Mark H.

    2014-01-01

    Single-atom catalysts are of great interest because of their high efficiency. In the case of chemically deposited sp2 carbon, the implementation of a single transition metal atom for growth can provide crucial insight into the formation mechanisms of graphene and carbon nanotubes. This knowledge is particularly important if we are to overcome fabrication difficulties in these materials and fully take advantage of their distinct band structures and physical properties. In this work, we present atomically resolved transmission EM in situ investigations of single Fe atoms at graphene edges. Our in situ observations show individual iron atoms diffusing along an edge either removing or adding carbon atoms (viz., catalytic action). The experimental observations of the catalytic behavior of a single Fe atom are in excellent agreement with supporting theoretical studies. In addition, the kinetics of Fe atoms at graphene edges are shown to exhibit anomalous diffusion, which again, is in agreement with our theoretical investigations. PMID:25331874

  8. Direct observation of the decay of beauty particles into charm particles

    International Nuclear Information System (INIS)

    Albanese, J.P.; Alpe, V.; Aoki, S.; Arnold, R.; Baroni, G.; Barth, M.; Bartley, J.H.; Bertrand, D.; Bertrand-Coremans, G.; Bisi, V.; Breslin, A.C.; Carboni, G.; Chesi, E.; Chiba, K.; Cook, G.S.; Coupland, M.; Crosetti, G.; Davis, D.H.; Dell'Uomo, S.; Di Liberto, S.; Bonnelly, W.; Duff, B.G.; Esten, M.J.; Gamba, D.; Gerke, C.; Hazama, M.; Heymann, F.F.; Hoshino, K.; Imrie, D.C.; Isokane, Y.; Kazuno, M.; Kodama, Y.; Lush, G.J.; Maeda, Y.; Marzari-Chiesa, A.; Mazzoni, M.A.; Meddi, F.; Miyanishi, M.; Montwill, A.; Muciaccia, M.T.; Musset, P.; Nakamura, M.; Nakazawa, K.; Natali, S.; Niu, K.; Niwa, K.; Nuzzo, S.; Ohashi, M.; Piuz, F.; Poulard, G.; Ramello, L.; Riccati, L.; Romano, G.; Roosen, R.; Rosa, G.; Ruggieri, F.; Sato, Y.; Sasaki, H.; Sgarbi, C.; Shibuya, H.; Simone, S.; Sletten, H.; Tasaka, S.; Tesuka, I.; Tomita, Y.; Tovee, D.N.; Trent, P.; Tsuneoka, Y.; Ushida, N.; Yamakawa, O.; Yanagisawa, Y.; Aichi Women's Coll., Nisshin-Cho; Bari Univ.; Istituto Nazionale di Fisica Nucleare, Bari; Birkbeck Coll., London; Interuniversity Inst. for High Energies, Brussels; European Organization for Nuclear Research, Geneva; University Coll., Dublin; Gifu Univ.; University Coll., London; Nagoya Univ.; Nagoya Inst. of Tech.; Rome Univ.; Istituto Nazionale di Fisica Nucleare, Rome; Toho Univ., Funabashi, Chiba; Istituto Nazionale di Fisica Nucleare, Turin; Turin Univ.; Utsunomiya Univ.; Yokohama National Univ.

    1985-01-01

    The associated production of a pair of beauty particles B - and anti B 0 by a 350 GeV π - interaction has been observed in an emulsion target inserted in an array of silicon microstrip detectors. Both beauty particles decay into charm particles, both of which are also observed to decay in the emulsion. Two negative muons were identified and their momenta measured in a large muon spectrometer. One muon has a psub(T) of 1.9 GeV/c and is associated with a beauty particle decay. The other, with a psub(T) of 0.45 GeV/c is associated with a charm particle decay. The flight times of the two beauty particles are respectively (0.8+-0.1).10 -13 s and (5sub(-1) +2 ).10 -13 s. Alternative interpretations of this event have negligible probability. (orig.)

  9. Direct observation of a 'devil's staircase' in wave-particle interaction

    International Nuclear Information System (INIS)

    Doveil, Fabrice; Macor, Alessandro; Elskens, Yves

    2006-01-01

    We report the experimental observation of a 'devil's staircase' in a time-dependent system considered as a paradigm for the transition to large-scale chaos in the universality class of Hamiltonian systems. A test electron beam is used to observe its non-self-consistent interaction with externally excited wave(s) in a traveling wave tube (TWT). A trochoidal energy analyzer records the beam energy distribution at the output of the interaction line. An arbitrary waveform generator is used to launch a prescribed spectrum of waves along the slow wave structure (a 4 m long helix) of the TWT. The resonant velocity domain associated to a single wave is observed, as well as the transition to large-scale chaos when the resonant domains of two waves and their secondary resonances overlap. This transition exhibits a 'devil's staircase' behavior for increasing excitation amplitude, due to the nonlinear forcing by the second wave on the pendulum-like motion of a charged particle in one electrostatic wave

  10. A direct observation method for auditing large urban centers using stratified sampling, mobile GIS technology and virtual environments.

    Science.gov (United States)

    Lafontaine, Sean J V; Sawada, M; Kristjansson, Elizabeth

    2017-02-16

    With the expansion and growth of research on neighbourhood characteristics, there is an increased need for direct observational field audits. Herein, we introduce a novel direct observational audit method and systematic social observation instrument (SSOI) for efficiently assessing neighbourhood aesthetics over large urban areas. Our audit method uses spatial random sampling stratified by residential zoning and incorporates both mobile geographic information systems technology and virtual environments. The reliability of our method was tested in two ways: first, in 15 Ottawa neighbourhoods, we compared results at audited locations over two subsequent years, and second; we audited every residential block (167 blocks) in one neighbourhood and compared the distribution of SSOI aesthetics index scores with results from the randomly audited locations. Finally, we present interrater reliability and consistency results on all observed items. The observed neighbourhood average aesthetics index score estimated from four or five stratified random audit locations is sufficient to characterize the average neighbourhood aesthetics. The SSOI was internally consistent and demonstrated good to excellent interrater reliability. At the neighbourhood level, aesthetics is positively related to SES and physical activity and negatively correlated with BMI. The proposed approach to direct neighbourhood auditing performs sufficiently and has the advantage of financial and temporal efficiency when auditing a large city.

  11. A DTN-ready application for the real-time dissemination of Earth Observation data received by Direct Readout stations

    Science.gov (United States)

    Paronis, Dimitris; Daglis, Ioannis A.; Diamantopoulos, Sotirios; Tsaoussidis, Vassilis; Tsigkanos, Antonis; Ghita, Bogdan; Evans, Michael

    2014-05-01

    The majority of Earth observation satellites operate in low Earth sun-synchronous orbit and transmit data captured by a variety of sensors. The effective dissemination of satellite data in real-time is a crucial parameter for disaster monitoring in particular. Generally, a spacecraft collects data and then stores it on-board until it passes over dedicated ground stations to transmit the data. Additionally, some satellites (e.g. Terra, Aqua, Suomi-NPP, NOAA series satellites) have the so-called Direct Broadcast (DB) capability, which is based on a real-time data transmission sub-system. Compatible Direct Readout (DR) stations in direct line of sight are able to receive these transmissions. To date data exchange between DR stations have not been fully exploited for real-time data dissemination. Stations around the world store data locally, which is then disseminated on demand via Internet gateways based on the standard TCP-IP protocols. On the other hand, Delay Tolerant Networks (DTNs), which deliver data by enabling store-and-forward transmission in order to cope with link failures, service disruptions and network congestion, could prove as an alternative/complementary transmission mechanism for the efficient dissemination of data. The DTN architecture allows for efficient utilization of the network, using in-network storage and taking advantage of the network availability among the interconnected nodes. Although DTNs were originally developed for high-propagation delay, challenged connectivity environments such as deep space, the broader research community has investigated possible architectural enhancements for various emerging applications (e.g., terrestrial infrastructure, ground-to-air communications, content retrieval and dissemination). In this paper, a scheme for the effective dissemination of DB data is conceptualized, designed and implemented based on store-and-forward transmission capabilities provided by DTNs. For demonstration purposes, a set-up has

  12. Direct dosing of preweaning rodents in toxicity testing and research: deliberations of an ILSI RSI Expert Working Group.

    Science.gov (United States)

    Moser, Virginia C; Walls, Isabel; Zoetis, Tracey

    2005-01-01

    Laboratory animal studies designed to assess the effects of exposure of a test substance during postnatal development are commonly utilized in basic research and to evaluate potential hazard to children for chemical and pharmaceutical regulation. Direct dosing, defined here as the administration of a test substance directly to a preweaning mammal, has been identified as a useful tool that can be used in the conduct of such studies for regulatory purposes. The International Life Sciences Institute Risk Science Institute (ILSI RSI) convened an Expert Working Group to develop guidance on the design and implementation of direct dosing regulatory studies on preweaning mammals, which was published as an ILSI monograph in 2003 (Zoetis and Walls, Principles and Practices for Direct Dosing of Pre-Weaning Mammals in Toxicity Testing and Research, Washington, DC: ILSI Press, 2003). A summary of the Working Group conclusions regarding direct dosing studies with laboratory rodents are presented here, although the ILSI monograph also includes rabbits, canines, swine and nonhuman primates. Issues to be considered when designing the protocol include selection of the test species, the route of administration, dose levels, and the timing of dosing. Knowledge of the maturational status of the test species and information on critical windows of development are important in creating a valid study design. Most common routes of administration (e.g., oral, inhalation, injection) are possible with typical laboratory species; however, adjustments may be necessary due to practical considerations. Information on the pharmacokinetic profile in young animals versus adults and in the test species versus humans is very useful for determining dosing parameters. The conduct of the study and the interpretation of the data will be improved by an understanding of confounding factors as well as statistical and biological issues specific for postnatal studies. Ultimately, the success of the study will

  13. Direct Observation of High-Temperature Superconductivity in One-Unit-Cell FeSe Films

    International Nuclear Information System (INIS)

    Zhang Wen-Hao; Zhang Jin-Song; Li Fang-Sen; Guo Ming-Hua; Ding Hao; Tang Chen-Jia; Wang Qing-Yan; He Ke; Ji Shuai-Hua; Chen Xi; Sun Yi; Zhao Yan-Fei; Xing Ying; Wang Hui-Chao; Zhang Hui-Min; Peng Jun-Ping; Li Zhi; Wang Meng; Fujita Takeshi; Hirata Akihiko

    2014-01-01

    We prepared one-unit-cell (1-UC) thick FeSe films on insulating SrTiO 3 substrates with non-superconducting FeTe protection layers by molecular beam epitaxy for ex situ studies. By direct transport and magnetic measurements, we provide definitive evidence for high temperature superconductivity in the 1-UC FeSe films with an onset T C above 40 K and an extremely large critical current density J C ∼1.7×10 6 A/cm 2 at 2 K, which are much higher than T C ∼8 K and J C ∼10 4 A/cm 2 for bulk FeSe, respectively. Our work may pave the way to enhancing and tailoring superconductivity by interface engineering. (express letter)

  14. Direct Observation of Insulin Association Dynamics with Time-Resolved X-ray Scattering

    Energy Technology Data Exchange (ETDEWEB)

    Rimmerman, Dolev [Department; Leshchev, Denis [Department; Hsu, Darren J. [Department; Hong, Jiyun [Department; Kosheleva, Irina [Center; Chen, Lin X. [Department; Chemical

    2017-09-05

    Biological functions frequently require protein-protein interactions that involve secondary and tertiary structural perturbation. Here we study protein-protein dissociation and reassociation dynamics in insulin, a model system for protein oligomerization. Insulin dimer dissociation into monomers was induced by a nanosecond temperature-jump (T-jump) of ~8 °C in aqueous solution, and the resulting protein and solvent dynamics were tracked by time-resolved X-ray solution scattering (TRXSS) on time scales of 10 ns to 100 ms. The protein scattering signals revealed the formation of five distinguishable transient species during the association process that deviate from simple two state kinetics. Our results show that the combination of T-jump pump coupled to TRXSS probe allows for direct tracking of structural dynamics in nonphotoactive proteins.

  15. Paul Trapping of Radioactive 6He+ Ions and Direct Observation of Their β Decay

    International Nuclear Information System (INIS)

    Flechard, X.; Lienard, E.; Mery, A.; Rodriguez, D.; Ban, G.; Durand, D.; Duval, F.; Herbane, M.; Labalme, M.; Mauger, F.; Naviliat-Cuncic, O.; Velten, Ph.; Thomas, J. C.

    2008-01-01

    We demonstrate that abundant quantities of short-lived β unstable ions can be trapped in a novel transparent Paul trap and that their decay products can directly be detected in coincidence. Low energy 6 He + (807 ms half-life) ions were extracted from the SPIRAL source at GANIL, then decelerated, cooled, and bunched by means of the buffer gas cooling technique. More than 10 8 ions have been stored over a measuring period of six days, and about 10 5 decay coincidences between the beta particles and the 6 Li ++ recoiling ions have been recorded. The technique can be extended to other short-lived species, opening new possibilities for trap assisted decay experiments

  16. Direct observation of the lowest indirect exciton state in the bulk of hexagonal boron nitride

    Science.gov (United States)

    Schuster, R.; Habenicht, C.; Ahmad, M.; Knupfer, M.; Büchner, B.

    2018-01-01

    We combine electron energy-loss spectroscopy and first-principles calculations based on density-functional theory (DFT) to identify the lowest indirect exciton state in the in-plane charge response of hexagonal boron nitride (h-BN) single crystals. This remarkably sharp mode forms a narrow pocket with a dispersion bandwidth of ˜100 meV and, as we argue based on a comparison to our DFT calculations, is predominantly polarized along the Γ K direction of the hexagonal Brillouin zone. Our data support the recent report by Cassabois et al. [Nat. Photonics 10, 262 (2016), 10.1038/nphoton.2015.277] who indirectly inferred the existence of this mode from the photoluminescence signal, thereby establishing h-BN as an indirect semiconductor.

  17. Direct Observation of Ultrafast Hole Injection from Lead Halide Perovskite by Differential Transient Transmission Spectroscopy.

    Science.gov (United States)

    Ishioka, Kunie; Barker, Bobby G; Yanagida, Masatoshi; Shirai, Yasuhiro; Miyano, Kenjiro

    2017-08-17

    Efficient charge separation at the interfaces of the perovskite with the carrier transport layers is crucial for perovskite solar cells to achieve high power conversion efficiency. We present a systematic experimental study on the hole injection dynamics from MAPbI 3 perovskite to three typical hole transport materials (HTMs). We extract the carrier dynamics directly related to the hole injection by employing a pump light with short absorption depth and comparing the transient transmission signals excited on the two sides of the sample. The differential transmission signals reveal the hole injections to PTAA and PEDOT:PSS to be complete within 1 and 2 ps, respectively, and that to NiO x to exhibit an additional slow process on a 40 ps time scale. The obtained injection dynamics are discussed in comparison with the device performance of the solar cells containing the same MAPbI 3 /HTM interfaces.

  18. Direct observation of elemental segregation in InGaN nanowires by X-ray nanoprobe

    Energy Technology Data Exchange (ETDEWEB)

    Segura-Ruiz, J.; Martinez-Criado, G.; Sans, J.A.; Tucoulou, R.; Cloetens, P.; Snigireva, I. [European Synchrotron Radiation Facility, Experiments Division, 38043 Grenoble (France); Denker, C.; Malindretos, J.; Rizzi, A. [Georg-August-University Goettingen, IV. Physikalisches Institut, 37077 Goettingen (Germany); Gomez-Gomez, M.; Garro, N.; Cantarero, A. [University of Valencia, Materials Science Institute, 46071 Valencia (Spain)

    2011-03-15

    Using synchrotron radiation nanoprobe, this work reports on the elemental distribution in single In{sub x} Ga{sub 1-x}N nanowires (NWs) grown by molecular beam epitaxy directly on Si(111) substrates. Single NWs dispersed on Al covered sapphire were characterized by nano-X-ray fluorescence, Raman scattering and photoluminescence spectroscopy. Both Ga and In maps reveal an inhomogeneous axial distribution inside sin- gle NWs. The analysis of NWs from the same sample but with different dimensions suggests a decrease of In segregation with the reduction of NW diameter, while Ga distribution seems to remain unaltered. Photoluminescence and Raman scattering measurements carried out on ensembles of NWs exhibit relevant signatures of the compositional disorder. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  19. Direct observation of elemental segregation in InGaN nanowires by X-ray nanoprobe

    International Nuclear Information System (INIS)

    Segura-Ruiz, J.; Martinez-Criado, G.; Sans, J.A.; Tucoulou, R.; Cloetens, P.; Snigireva, I.; Denker, C.; Malindretos, J.; Rizzi, A.; Gomez-Gomez, M.; Garro, N.; Cantarero, A.

    2011-01-01

    Using synchrotron radiation nanoprobe, this work reports on the elemental distribution in single In x Ga 1-x N nanowires (NWs) grown by molecular beam epitaxy directly on Si(111) substrates. Single NWs dispersed on Al covered sapphire were characterized by nano-X-ray fluorescence, Raman scattering and photoluminescence spectroscopy. Both Ga and In maps reveal an inhomogeneous axial distribution inside sin- gle NWs. The analysis of NWs from the same sample but with different dimensions suggests a decrease of In segregation with the reduction of NW diameter, while Ga distribution seems to remain unaltered. Photoluminescence and Raman scattering measurements carried out on ensembles of NWs exhibit relevant signatures of the compositional disorder. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  20. Observation of seasonal effects in traveling ionospheric disturbances by the directional deviation technique

    International Nuclear Information System (INIS)

    Walton, E.K.; Bailey, A.D.

    1976-01-01

    An experiment was performed during the years 1962 through 1964 in which direction of arrival data were collected on pulse signals received over a 450 km east-west path. In order to determine the effect that traveling ionospheric disturbances (TIDs) had on these data, a ''corrugation'' model was proposed. The corrugation model assumes that TIDs can be treated as if they were moving cylindrical sinusoidal perturbations on the ionospheric reflecting surface. Lateral deviations in the experimental data of the type predicted by this model were found to be quite common. Variations in the detected TIDs as a function of time of year were found to be consistent with the ''seasonal effect'' studied by Munro in 1958, Jones 1969, and Davies and Jones in 1971

  1. A Flexible Reporter System for Direct Observation and Isolation of Cancer Stem Cells

    Directory of Open Access Journals (Sweden)

    Binwu Tang

    2015-01-01

    Full Text Available Many tumors are hierarchically organized with a minority cell population that has stem-like properties and enhanced ability to initiate tumorigenesis and drive therapeutic relapse. These cancer stem cells (CSCs are typically identified by complex combinations of cell-surface markers that differ among tumor types. Here, we developed a flexible lentiviral-based reporter system that allows direct visualization of CSCs based on functional properties. The reporter responds to the core stem cell transcription factors OCT4 and SOX2, with further selectivity and kinetic resolution coming from use of a proteasome-targeting degron. Cancer cells marked by this reporter have the expected properties of self-renewal, generation of heterogeneous offspring, high tumor- and metastasis-initiating activity, and resistance to chemotherapeutics. With this approach, the spatial distribution of CSCs can be assessed in settings that retain microenvironmental and structural cues, and CSC plasticity and response to therapeutics can be monitored in real time.

  2. Direct observation of two-step crystallization in nanoparticle superlattice formation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jungwon; Zheng, Haimei; Lee, Won Chul; Geissler, Phillip L.; Rabani, Eran; Alivisatos, A. Paul

    2011-10-06

    Direct imaging of nanoparticle solutions by liquid phase transmission electron microscopy has enabled unique in-situ studies of nanoparticle motion and growth. In the present work, we report on real-time formation of two-dimensional nanoparticle arrays in the very low diffusive limit, where nanoparticles are mainly driven by capillary forces and solvent fluctuations. We find that superlattice formation appears to be segregated into multiple regimes. Initially, the solvent front drags the nanoparticles, condensing them into an amorphous agglomerate. Subsequently, the nanoparticle crystallization into an array is driven by local fluctuations. Following the crystallization event, superlattice growth can also occur via the addition of individual nanoparticles drawn from outlying regions by different solvent fronts. The dragging mechanism is consistent with simulations based on a coarse-grained lattice gas model at the same limit.

  3. Direct observation of mother-child communication in pediatric cancer: assessment of verbal and non-verbal behavior and emotion.

    Science.gov (United States)

    Dunn, Madeleine J; Rodriguez, Erin M; Miller, Kimberly S; Gerhardt, Cynthia A; Vannatta, Kathryn; Saylor, Megan; Scheule, C Melanie; Compas, Bruce E

    2011-06-01

    To examine the acceptability and feasibility of coding observed verbal and nonverbal behavioral and emotional components of mother-child communication among families of children with cancer. Mother-child dyads (N=33, children ages 5-17 years) were asked to engage in a videotaped 15-min conversation about the child's cancer. Coding was done using the Iowa Family Interaction Rating Scale (IFIRS). Acceptability and feasibility of direct observation in this population were partially supported: 58% consented and 81% of those (47% of all eligible dyads) completed the task; trained raters achieved 78% agreement in ratings across codes. The construct validity of the IFIRS was demonstrated by expected associations within and between positive and negative behavioral/emotional code ratings and between mothers' and children's corresponding code ratings. Direct observation of mother-child communication about childhood cancer has the potential to be an acceptable and feasible method of assessing verbal and nonverbal behavior and emotion in this population.

  4. DIRECT AND INDIRECT FLUORESCENT-ANTIBODY TECHNIQUES FOR THE PSITTACOSIS-LYMPHOGRANULOMA VENEREUM-TRACHOMA GROUP OF AGENTS1

    Science.gov (United States)

    Ross, Martin R.; Borman, Earle K.

    1963-01-01

    Ross, Martin R. (Connecticut State Department of Health, Hartford) and Earle K. Borman. Direct and indirect fluorescent-antibody techniques for the psittacosis-lymphogranuloma venereum-trachoma group of agents. J. Bacteriol. 85:851–858. 1963.—Direct and indirect fluorescent-antibody (FA) techniques were developed for the detection of group antigen in infected tissue cultures and the titration of group antibody in human antiserum. The growth of the agent of meningopneumonitis (MP) in mouse embryo lung cell monolayers was followed by infectivity and complement-fixing (CF) antigen titrations, and cytological examination of FA stained cultures. Although infectivity and CF antigen reached a peak at 2 days and remained constant for an additional 3 days, only cells tested 2 to 3 days after infection were suitable for FA staining with labeled anti-MP serum because of excessive artifacts in the older cultures. Fluorescein isothiocyanate-labeled rooster and guinea pig anti-MP serums and human antipsittacosis serums were titrated in direct FA and hemagglutination-inhibition (HI) tests. The rooster conjugate showed brighter staining and higher antibody titers than the guinea pig or human conjugates and was more effective in detecting minimal amounts of virus antigen. FA staining reactions with 1 and 2 units of labeled rooster serum were inhibited by unlabeled rooster serum but clear-cut inhibition with human antipsittacosis serum could not be demonstrated. The indirect FA technique was successfully used for the titration of group antibody in human serum. A comparison of the indirect FA, HI, and CF tests showed the indirect FA technique to be intermediate in sensitivity between the HI and CF tests. None of the three tests showed significant cross reactions with human serums reactive for influenza A and B; parainfluenza 1, 2, and 3; respiratory syncytial virus; Q fever; or the primary atypical pneumonia agent. PMID:14044954

  5. Trend of tuberculosis cases under directly observed treatment, short-course strategy in Tabriz, Iran, from 2001 to 2011

    Directory of Open Access Journals (Sweden)

    Zhila Khamnian

    2016-02-01

    Full Text Available Introduction: The universal target under the Millennium Development Goals (MDGs is to reduce the worldwide burden of tuberculosis (TB 2015, and we wanted to evaluate development in TB control by assessment of the time trend in incidence and death rate in Tabriz, Iran. Methods: This was a retrospective trend analysis of the data have been recorded in East Azerbaijan State TB center during 10 years. Data were related to patients have been registered for treatment under the directly observed treatment, short-course (DOTS strategy from 2001 to 2011. Results: In total, 3283 TB patients were treated under DOTS strategy during 2001-2011. Males constituted 55.0% of subjects. The risk was the highest among the productive age group (15-44 years. About 61.0% of cases had pulmonary, and 78.0% of pulmonary TB patients were found to be the sputum smear positive than 46.0% of them were new sputum smear positive, and 2.0% of them were relapse. On average, for sputum smear positive, TB cases from 2005 to 2011; the treatment success rate was 87.3%; the cure rate was 80.2%; the treatment failure rate was 0.5% and death rate was 10.3%. In general, the TB incidence rate for all TB cases was decreased from 11.9-8.1 a 100000 population and the smear-positive pulmonary TB incidence rate were decreased from 4.7 to 4.1 a 100000 population in eastern Azerbaijan province during 2001-2011. Conclusion: In general, we had a decrease in the incidence rate for all of TB cases. In addition, we had a fall in cure rate and had an increase in drug side effects rate in this year that can be because of elevated old people ratio and high death rate by other indirect causes and lack of regular visits and medications taking according to the treatment protocol.

  6. Direct observation of the hydrogen peak in the energy distribution of electrons backscattered elastically from polyethylene

    International Nuclear Information System (INIS)

    Varga, D.; Toekesi, K.; Berenyi, Z.; Toth, J.; Koever, L.

    2004-01-01

    Complete text of publication follows. Observation of the hydrogen peak is either challenging or impossible task for the conventional electron spectroscopy. Hydrogen was observed earlier in electron scattering experiments using transmission geometry and formvar film. In this work we show an alternative way for the detection of hydrogen peak analyzing the spectra of elastically backscattered electrons from polyethylene ((CH 2 ) n ). We take advantage of the fact that the elastic peak from polyethylene split into carbon and hydrogen components. The energy of the elastically scattered electrons is shifted from the nominal values due to the energy transfer between the primary electron and the target atoms (recoil effect). Due to the motion of the scattering atoms, a broadering of the energy width of the spectra takes place. We performed Monte Carlo simulation for 2 keV electrons penetrated and elastically backscattered from polyethylene sample. In our calculations both the elastic and inelastic scattering events were taken into account. We further assume that the thermal motion of the target atoms follows the Maxwell-Boltzmann energy distribution. After each elastic scattering the recoil energy was calculated according to ref Fig. 1 shows the geometric configuration used in the calculation. The initial angle of incident beam (θ) was 50 deg. Fig. 2 shows the gray scale plot of the intensity of electrons backscattered elastically from polyethylene. The separation between the carbon and hydrogen peaks is clearly seen. Our results show that the multiple electron scattering causes only minor changes in the energy shifts and broadenings of elastic peaks. Moreover, our simulations are in good agreement with our experimental observations. (author)

  7. Direct Observations of Magnetic Flux Rope Formation during a Solar Coronal Mass Ejection

    Science.gov (United States)

    Song, H.; Zhang, J.; Chen, Y.; Cheng, X.

    2014-12-01

    Coronal mass ejections (CMEs) are the most spectacular eruptive phenomena in the solar atmosphere. It is generally accepted that CMEs are results of eruptions of magnetic flux ropes (MFRs). However, a heated debate is on whether MFRs pre-exist before the eruptions or they are formed during the eruptions. Several coronal signatures, e.g., filaments, coronal cavities, sigmoid structures and hot channels (or hot blobs), are proposed as MFRs and observed before the eruption, which support the pre existing MFR scenario. There is almost no reported observation about MFR formation during the eruption. In this presentation, we present an intriguing observation of a solar eruptive event with the Atmospheric Imaging Assembly on board the Solar Dynamic Observatory, which shows a detailed formation process of the MFR during the eruption. The process started with the expansion of a low lying coronal arcade, possibly caused by the flare magnetic reconnection underneath. The newly-formed ascending loops from below further pushed the arcade upward, stretching the surrounding magnetic field. The arcade and stretched magnetic field lines then curved-in just below the arcade vertex, forming an X-point. The field lines near the X-point continued to approach each other and a second magnetic reconnection was induced. It is this high-lying magnetic reconnection that led to the formation and eruption of a hot blob (~ 10 MK), presumably a MFR, producing a CME. We suggest that two spatially-separated magnetic reconnections occurred in this event, responsible for producing the flare and the hot blob (CME), respectively.

  8. DIRECT OBSERVATIONS OF MAGNETIC FLUX ROPE FORMATION DURING A SOLAR CORONAL MASS EJECTION

    International Nuclear Information System (INIS)

    Song, H. Q.; Chen, Y.; Zhang, J.; Cheng, X.

    2014-01-01

    Coronal mass ejections (CMEs) are the most spectacular eruptive phenomena in the solar atmosphere. It is generally accepted that CMEs are the results of eruptions of magnetic flux ropes (MFRs). However, there is heated debate on whether MFRs exist prior to the eruptions or if they are formed during the eruptions. Several coronal signatures, e.g., filaments, coronal cavities, sigmoid structures, and hot channels (or hot blobs), are proposed as MFRs and observed before the eruption, which support the pre-existing MFR scenario. There is almost no reported observation of MFR formation during the eruption. In this Letter, we present an intriguing observation of a solar eruptive event that occurred on 2013 November 21 with the Atmospheric Imaging Assembly on board the Solar Dynamic Observatory, which shows the formation process of the MFR during the eruption in detail. The process began with the expansion of a low-lying coronal arcade, possibly caused by the flare magnetic reconnection underneath. The newly formed ascending loops from below further pushed the arcade upward, stretching the surrounding magnetic field. The arcade and stretched magnetic field lines then curved in just below the arcade vertex, forming an X-point. The field lines near the X-point continued to approach each other and a second magnetic reconnection was induced. It is this high-lying magnetic reconnection that led to the formation and eruption of a hot blob (∼10 MK), presumably an MFR, producing a CME. We suggest that two spatially separated magnetic reconnections occurred in this event, which were responsible for producing the flare and the hot blob (CME)

  9. DIRECT OBSERVATIONS OF MAGNETIC FLUX ROPE FORMATION DURING A SOLAR CORONAL MASS EJECTION

    Energy Technology Data Exchange (ETDEWEB)

    Song, H. Q.; Chen, Y. [Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment and Institute of Space Sciences, Shandong University, Weihai, Shandong 264209 (China); Zhang, J. [School of Physics, Astronomy and Computational Sciences, George Mason University, Fairfax, VA 22030 (United States); Cheng, X., E-mail: hqsong@sdu.edu.cn [School of Astronomy and Space Science, Nanjing University, Nanjing, Jiangsu 210093 (China)

    2014-09-10

    Coronal mass ejections (CMEs) are the most spectacular eruptive phenomena in the solar atmosphere. It is generally accepted that CMEs are the results of eruptions of magnetic flux ropes (MFRs). However, there is heated debate on whether MFRs exist prior to the eruptions or if they are formed during the eruptions. Several coronal signatures, e.g., filaments, coronal cavities, sigmoid structures, and hot channels (or hot blobs), are proposed as MFRs and observed before the eruption, which support the pre-existing MFR scenario. There is almost no reported observation of MFR formation during the eruption. In this Letter, we present an intriguing observation of a solar eruptive event that occurred on 2013 November 21 with the Atmospheric Imaging Assembly on board the Solar Dynamic Observatory, which shows the formation process of the MFR during the eruption in detail. The process began with the expansion of a low-lying coronal arcade, possibly caused by the flare magnetic reconnection underneath. The newly formed ascending loops from below further pushed the arcade upward, stretching the surrounding magnetic field. The arcade and stretched magnetic field lines then curved in just below the arcade vertex, forming an X-point. The field lines near the X-point continued to approach each other and a second magnetic reconnection was induced. It is this high-lying magnetic reconnection that led to the formation and eruption of a hot blob (∼10 MK), presumably an MFR, producing a CME. We suggest that two spatially separated magnetic reconnections occurred in this event, which were responsible for producing the flare and the hot blob (CME)

  10. Direct observation of the vacancy structure of depleted zones in tungsten ion irradiated at 100K

    International Nuclear Information System (INIS)

    Wei, C.Y.; Seidman, D.N.

    1978-12-01

    The structure of depleted zones (DZs) created by the in-situ irradiation of tungsten specimens, at 10 0 K, with 30 keV W + , Mo + or Cr + ions has been studied by field-ion microscopy. As the mass of the 30 keV ion was decreased the following observations were made: (1) the spatial extent of the DZs increased; (2) the vacancy concentration within the DZs decreased; (3) the fraction of isolated monovacancies increased; and (4) subcascades formed within the DZs

  11. Direct Observation of Dislocation Core Structures in CdTe/GaAs(001).

    Science.gov (United States)

    McGibbon, A J; Pennycook, S J; Angelo, J E

    1995-07-28

    A strategy is presented for determining sublattice polarity at defects in compound semiconductors. Core structures of 60-degree and Lomer dislocations in the CdTe/GaAs(001) system have been obtained by the application of maximum-entropy analysis to Z-contrast images (Z is atomic number) obtained in a 300-kilovolt scanning transmission electron microscope. Sixty-degree dislocations were observed to be of the glide type, whereas in the case of Lomer dislocations, both a symmetric (Hornstra-like) core and an unexpected asymmetric structure made up of a fourfold ring were seen.

  12. Extreme ultraviolet spectroscopy of G191-B2B - Direct observation of ionization edges

    Science.gov (United States)

    Wilkinson, Erik; Green, James C.; Cash, Webster

    1992-01-01

    We present the first spectrum of the hot, DA white dwarf G191-B2B (wd 0501 + 527) between 200 and 330 A. The spectrum, which has about 2 A resolution, was obtained with a sounding rocket-borne, grazing incidence spectrograph. The spectrum shows no evidence of He II, the expected primary opacity source in this wavelength region. Three ionization edges and one absorption feature were observed and are suggestive of O III existing in the photosphere of G191-B2B. Also noted is a broad spectral depression that may result from Fe VI in the photosphere.

  13. Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry.

    Science.gov (United States)

    Call, Jerry; Walentas, Christopher D; Eickhoff, Jens C; Scherzer, Norman

    2012-03-19

    Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or leiomyoblastomas. Since the advent of imatinib, GIST has been further delineated into adult- (KIT or PDGFRα mutations) and pediatric- (typified by wild-type GIST/succinate dehydrogenase deficiencies) types. Using varying gender ratios at age of diagnosis we sought to elucidate prognostic factors for each sub-type and their impact on overall survival. This is a long-term retrospective analysis of a large observational study of an international open cohort of patients from a GIST research and patient advocacy's lifetime registry. Demographic and disease-specific data were voluntarily supplied by its members from May 2000-October 2010; the primary outcome was overall survival. Associations between survival and prognostic factors were evaluated by univariate Cox proportional hazard analyses, with backward selection at P diligence be taken with "young adults" (aged 18-35 at diagnosis) as pediatric-type GIST may present well beyond adolescence, particularly as these distinct sub-types have different causes, and consequently respond differently to treatments.

  14. Molecular typing for blood group antigens within 40 min by direct polymerase chain reaction from plasma or serum.

    Science.gov (United States)

    Wagner, Franz F; Flegel, Willy A; Bittner, Rita; Döscher, Andrea

    2017-03-01

    Determining blood group antigens by serological methods may be unreliable in certain situations, such as in patients after chronic or massive transfusion. Red cell genotyping offers a complementary approach, but current methods may take much longer than conventional serological typing, limiting their utility in urgent situations. To narrow this gap, we devised a rapid method using direct polymerase chain reaction (PCR) amplification while avoiding the DNA extraction step. DNA was amplified by PCR directly from plasma or serum of blood donors followed by a melting curve analysis in a capillary rapid-cycle PCR assay. We evaluated the single nucleotide polymorphisms underlying the clinically relevant Fy a , Fy b , Jk a and Jk b antigens, with our analysis being completed within 40 min of receiving a plasma or serum sample. The positive predictive value was 100% and the negative predictive value at least 84%. Direct PCR with melting point analysis allowed faster red cell genotyping to predict blood group antigens than any previous molecular method. Our assay may be used as a screening tool with subsequent confirmatory testing, within the limitations of the false-negative rate. With fast turnaround times, the rapid-cycle PCR assay may eventually be developed and applied to red cell genotyping in the hospital setting. © 2016 John Wiley & Sons Ltd.

  15. Development of a direct observation Measure of Environmental Qualities of Activity Settings.

    Science.gov (United States)

    King, Gillian; Rigby, Patty; Batorowicz, Beata; McMain-Klein, Margot; Petrenchik, Theresa; Thompson, Laura; Gibson, Michelle

    2014-08-01

    The aim of this study was to develop an observer-rated measure of aesthetic, physical, social, and opportunity-related qualities of leisure activity settings for young people (with or without disabilities). Eighty questionnaires were completed by sets of raters who independently rated 22 community/home activity settings. The scales of the 32-item Measure of Environmental Qualities of Activity Settings (MEQAS; Opportunities for Social Activities, Opportunities for Physical Activities, Pleasant Physical Environment, Opportunities for Choice, Opportunities for Personal Growth, and Opportunities to Interact with Adults) were determined using principal components analyses. Test-retest reliability was determined for eight activity settings, rated twice (4-6wk interval) by a trained rater. The factor structure accounted for 80% of the variance. The Kaiser-Meyer-Olkin Measure of Sampling Adequacy was 0.73. Cronbach's alphas for the scales ranged from 0.76 to 0.96, and interrater reliabilities (ICCs) ranged from 0.60 to 0.93. Test-retest reliabilities ranged from 0.70 to 0.90. Results suggest that the MEQAS has a sound factor structure and preliminary evidence of internal consistency, interrater, and test-retest reliability. The MEQAS is the first observer-completed measure of environmental qualities of activity settings. The MEQAS allows researchers to assess comprehensively qualities and affordances of activity settings, and can be used to design and assess environmental qualities of programs for young people. © 2014 Mac Keith Press.

  16. Assessment of operating room airflow using air particle counts and direct observation of door openings.

    Science.gov (United States)

    Teter, Jonathan; Guajardo, Isabella; Al-Rammah, Tamrah; Rosson, Gedge; Perl, Trish M; Manahan, Michele

    2017-05-01

    The role of the operating room (OR) environment has been thought to contribute to surgical site infection rates. The quality of OR air, disruption of airflow, and other factors may increase contamination risks. We measured air particulate counts (APCs) to determine if they increased in relation to traffic, door opening, and other common activities. During 1 week, we recorded APCs in 5-minute intervals and movement of health care workers. Trained observers recorded information about traffic, door openings, job title of the opener, and the reason for opening. At least 1 OR door was open during 47% of all readings. There were 13.4 door openings per hour during cases. Door opening rates ranged from 0.19-0.28 per minute. During this time, a total of 660 air measurements were obtained. The mean APCs were 9,238 particles (95% confidence interval [CI], 5,494- 12,982) at baseline and 14,292 particles (95% CI, 12,382-16,201) during surgery. Overall APCs increased 13% when either door was opened (P opening. We observed numerous instances of verbal communication and equipment movement. Improving efficiency of communication and equipment can aid in reduction of traffic. Further study is needed to examine links between microbiologic sampling, outcome data, and particulate matter to enable study of risk factors and effects of personnel movement. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  17. Direct observation of ozone formation on SiO2 surfaces in O2 discharges

    Science.gov (United States)

    Marinov, D.; Guaitella, O.; Booth, J. P.; Rousseau, A.

    2013-01-01

    Ozone production is studied in a pulsed O2 discharge at pressures in the range 1.3-6.7 mbar. Time-resolved absolute concentrations of O3 and O are measured in the post-discharge using UV absorption spectroscopy and two-photon absorption laser-induced fluorescence. In a bare silica discharge tube ozone is formed mainly by three-body gas-phase recombination. When the tube surface is covered by a high specific surface silica catalyst heterogeneous formation becomes the main source of ozone. The efficiency of this surface process increases with O2 pressure and is favoured by the presence of OH groups and adsorbed H2O on the surface. At p = 6.7 mbar ozone production accounts for up to 25% of the atomic oxygen losses on the surface.

  18. Direct observation of ozone formation on SiO2 surfaces in O2 discharges

    International Nuclear Information System (INIS)

    Marinov, D; Guaitella, O; Booth, J P; Rousseau, A

    2013-01-01

    Ozone production is studied in a pulsed O 2 discharge at pressures in the range 1.3-6.7 mbar. Time-resolved absolute concentrations of O 3 and O are measured in the post-discharge using UV absorption spectroscopy and two-photon absorption laser-induced fluorescence. In a bare silica discharge tube ozone is formed mainly by three-body gas-phase recombination. When the tube surface is covered by a high specific surface silica catalyst heterogeneous formation becomes the main source of ozone. The efficiency of this surface process increases with O 2 pressure and is favoured by the presence of OH groups and adsorbed H 2 O on the surface. At p = 6.7 mbar ozone production accounts for up to 25% of the atomic oxygen losses on the surface.

  19. Direct observation of the release of alkali vapor species in biofuel combustion and gasification

    Energy Technology Data Exchange (ETDEWEB)

    French, R.J.; Milne, T.A. [National Renewable Energy Lab., Golden, CO (United States)

    1993-12-31

    The largest present use of biomass for energy is in combustion for steam and electrical power. Biofuels have an acknowledged advantage over coal as a solid fuel because of their low sulfur and ash content. However, some forms of biomass have substantial quantities of alkali metals and chlorine. In addition, evidence indicates that the alkali in biomass is largely atomically dispersed, resulting in its facile mobilization into the gas-phase. Gaseous alkali compounds aggravate problems of slagging, fouling, and corrosion on heat transfer surfaces in present-day boilers. These problems can be particularly severe when mixed and variable agricultural residues are burned. Furthermore, the next generation of biomass-to-power systems will likely involve combined cycle gas turbines, where alkali tolerances are especially restrictive. In this paper, we report on laboratory studies in which biofuels are combusted under simulated turbine or boiler-firing conditions. Gaseous alkali, sulfur, nitrogen, and halogen-containing species are measured by direct extraction from the hot gases through molecular-beam mass spectrometry (MBMS). The experimental apparatus will be described and its capability illustrated with results of time-resolved evolution of species like K, KCl, KOH, SO{sub 2} and NO{sub x} from small samples of biomass in combustion environments. The nature and release of such species will be explicated by referring to thermodynamic equilibrium predictions and the form of alkali in solid, gaseous, and liquid biofuels.

  20. The breakup of large tabular icebergs - direct observations and theoretical considerations

    Science.gov (United States)

    Wadhams, P.

    2013-12-01

    Peter Wadhams and Till Wagner Dept. of Applied Mathematics and Theoretical Physics (DAMTP), University of Cambridge. We review the factors governing the stability, dynamics and decay of icebergs and describe areas where current models are inadequate. These include questions such as draft changes in capsizing icebergs; iceberg trajectory modelling; the melt rate of the ice underside and ways of reducing it; and wave-induced flexure and its role in the break-up of tabular icebergs. In July 2012 the authors worked on a very large (42 sq km) tabular iceberg in Baffin Bay, which had calved from the Petermann Glacier in NW Greenland. We measured incoming swell spectrum and the iceberg response; also the role of buoyancy forces due to erosion of a waterline wave cut and the creation of an underwater ram. The iceberg broke up while we were on it, allowing an instrumental measurement of the calving event. The experiments were included in the BBC-2 film 'Operation Iceberg' shown on Nov 1 2012 and repeated on Nov 18. We conclude that two processes interacted in the break-up event: increased bending stress due to buoyancy of underwater rams; and direct flexural strain due to incidence of ocean swell. Implications for icebergs in the open sea are estimated.

  1. Direct observation of local xylem embolisms induced by soil drying in intact Zea mays leaves.

    Science.gov (United States)

    Ryu, Jeongeun; Hwang, Bae Geun; Kim, Yangmin X; Lee, Sang Joon

    2016-04-01

    The vulnerability of vascular plants to xylem embolism is closely related to their stable long-distance water transport, growth, and survival. Direct measurements of xylem embolism are required to understand what causes embolism and what strategies plants employ against it. In this study, synchrotron X-ray microscopy was used to non-destructively investigate both the anatomical structures of xylem vessels and embolism occurrence in the leaves of intact Zea mays (maize) plants. Xylem embolism was induced by water stress at various soil drying periods and soil water contents. X-ray images of dehydrated maize leaves showed that the ratio of gas-filled vessels to all xylem vessels increased with decreased soil water content and reached approximately 30% under severe water stress. Embolism occurred in some but not all vessels. Embolism in maize leaves was not strongly correlated with xylem diameter but was more likely to occur in the peripheral veins. The rate of embolism formation in metaxylem vessels was higher than in protoxylem vessels. This work has demonstrated that xylem embolism remains low in maize leaves under water stress and that there xylem has characteristic spatial traits of vulnerability to embolism. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  2. Direct observation of ultrafast long-range charge separation at polymer–fullerene heterojunctions

    KAUST Repository

    Provencher, Franç oise; Bé rubé , Nicolas; Parker, Anthony W.; Greetham, Gregory M.; Towrie, Michael; Hellmann, Christoph; Cô té , Michel; Stingelin, Natalie; Silva, Carlos; Hayes, Sophia C.

    2014-01-01

    In polymeric semiconductors, charge carriers are polarons, which means that the excess charge deforms the molecular structure of the polymer chain that hosts it. This results in distinctive signatures in the vibrational modes of the polymer. Here, we probe polaron photogeneration dynamics at polymer:fullerene heterojunctions by monitoring its time-resolved resonance-Raman spectrum following ultrafast photoexcitation. We conclude that polarons emerge within 300 fs. Surprisingly, further structural evolution on ≤50-ps timescales is modest, indicating that the polymer conformation hosting nascent polarons is not significantly different from that near equilibrium. We interpret this as suggestive that charges are free from their mutual Coulomb potential because we would expect rich vibrational dynamics associated with charge-pair relaxation. We address current debates on the photocarrier generation mechanism at molecular heterojunctions, and our work is, to our knowledge, the first direct probe of molecular conformation dynamics during this fundamentally important process in these materials. © 2014 Macmillan Publishers Limited. All rights reserved.

  3. What is the probability that direct detection experiments have observed dark matter?

    International Nuclear Information System (INIS)

    Bozorgnia, Nassim; Schwetz, Thomas

    2014-01-01

    In Dark Matter direct detection we are facing the situation of some experiments reporting positive signals which are in conflict with limits from other experiments. Such conclusions are subject to large uncertainties introduced by the poorly known local Dark Matter distribution. We present a method to calculate an upper bound on the joint probability of obtaining the outcome of two potentially conflicting experiments under the assumption that the Dark Matter hypothesis is correct, but completely independent of assumptions about the Dark Matter distribution. In this way we can quantify the compatibility of two experiments in an astrophysics independent way. We illustrate our method by testing the compatibility of the hints reported by DAMA and CDMS-Si with the limits from the LUX and SuperCDMS experiments. The method does not require Monte Carlo simulations but is mostly based on using Poisson statistics. In order to deal with signals of few events we introduce the so-called ''signal length'' to take into account energy information. The signal length method provides a simple way to calculate the probability to obtain a given experimental outcome under a specified Dark Matter and background hypothesis

  4. Polymer tensiometers with ceramic cones: direct observations of matric pressures in drying soils

    Directory of Open Access Journals (Sweden)

    M. J. van der Ploeg

    2010-10-01

    Full Text Available Measuring soil water potentials is crucial to characterize vadose zone processes. Conventional tensiometers only measure until approximately −0.09 MPa, and indirect methods may suffer from the non-uniqueness in the relationship between matric potential and measured properties. Recently developed polymer tensiometers (POTs are able to directly measure soil matric potentials until the theoretical wilting point (−1.6 MPa. By minimizing the volume of polymer solution inside the POT while maximizing the ceramic area in contact with that polymer solution, response times drop to acceptable ranges for laboratory and field conditions. Contact with the soil is drastically improved with the use of cone-shaped solid ceramics instead of flat ceramics. The comparison between measured potentials by polymer tensiometers and indirectly obtained potentials with time domain reflectometry highlights the risk of using the latter method at low water contents. By combining POT and time domain reflectometry readings in situ moisture retention curves can be measured over the range permitted by the measurement range of both POT and time domain reflectometry.

  5. Direct observation of ultrafast long-range charge separation at polymer–fullerene heterojunctions

    KAUST Repository

    Provencher, Françoise

    2014-07-01

    In polymeric semiconductors, charge carriers are polarons, which means that the excess charge deforms the molecular structure of the polymer chain that hosts it. This results in distinctive signatures in the vibrational modes of the polymer. Here, we probe polaron photogeneration dynamics at polymer:fullerene heterojunctions by monitoring its time-resolved resonance-Raman spectrum following ultrafast photoexcitation. We conclude that polarons emerge within 300 fs. Surprisingly, further structural evolution on ≤50-ps timescales is modest, indicating that the polymer conformation hosting nascent polarons is not significantly different from that near equilibrium. We interpret this as suggestive that charges are free from their mutual Coulomb potential because we would expect rich vibrational dynamics associated with charge-pair relaxation. We address current debates on the photocarrier generation mechanism at molecular heterojunctions, and our work is, to our knowledge, the first direct probe of molecular conformation dynamics during this fundamentally important process in these materials. © 2014 Macmillan Publishers Limited. All rights reserved.

  6. Observation of internucleotide NH...N hydrogen bonds in the absence of directly detectable protons

    International Nuclear Information System (INIS)

    Majumdar, Ananya; Kettani, Abdelali; Skripkin, Eugene; Patel, Dinshaw J.

    1999-01-01

    Several structural motifs found in nucleic acids involve N-H ... N hydrogen bonds in which the donor hydrogens are broadened to extinction due to chemical or conformational exchange. In such situations, it is impossible to use the well-established HNN-COSY or soft HNN-COSY experiments, which report the presence of the hydrogen bond directly on the donor proton(s). We present a pulse sequence, H(CN)N(H), for alleviating this problem in hydrogen bonds of the type N d H ... N a -CH, in which the donor N d nitrogen is correlated with the corresponding non-exchangeable C-H proton associated with the acceptor N a nitrogen. In this way, missing N d H ... N a correlations in an HNN-COSY spectrum may be recovered from CH-N d correlations in the H(CN)N(H) spectrum. By correlating a different set of nuclei relative to the HNN-COSY class of experiments, the H(CN)N(H) experiment also serves to remove ambiguities associated with degeneracies in HNN-COSY spectra. The technique is demonstrated on d(GGAGGAG) 4 ,a quadruplex containing a novel A . (G . G . G . G) . A hexad and on d(GGGCAGGT) 4 , containing a G . C . G . C tetrad, in which missing NH 2 ... N7 correlations are retrieved via H8-(N2,N6) correlations in the H(CN)N(H) spectrum

  7. The direct observation of alkali vapor species in biomass combustion and gasification

    Energy Technology Data Exchange (ETDEWEB)

    French, R J; Dayton, D C; Milne, T A

    1994-01-01

    This report summarizes new data from screening various feedstocks for alkali vapor release under combustion conditions. The successful development of a laboratory flow reactor and molecular beam, mass spectrometer interface is detailed. Its application to several herbaceous and woody feedstocks, as well as a fast-pyrolysis oil, under 800 and 1,100{degrees}C batch combustion, is documented. Chlorine seems to play a large role in the facile mobilization of potassium. Included in the report is a discussion of relevant literature on the alkali problem in combustors and turbines. Highlighted are the phenomena identified in studies on coal and methods that have been applied to alkali speciation. The nature of binding of alkali in coal versus biomass is discussed, together with the implications for the ease of release. Herbaceous species and many agricultural residues appear to pose significant problems in release of alkali species to the vapor at typical combustor temperatures. These problems could be especially acute in direct combustion fired turbines, but may be ameliorated in integrated gasification combined cycles.

  8. Direct observation and quantification of nanoscale spinodal decomposition in super duplex stainless steel weld metals.

    Science.gov (United States)

    Shariq, Ahmed; Hättestrand, Mats; Nilsson, Jan-Olof; Gregori, Andrea

    2009-06-01

    Three variants of super duplex stainless steel weld metals with the basic composition 29Cr-8Ni-2Mo (wt%) were investigated. The nitrogen content of the three materials was 0.22%, 0.33% and 0.37%, respectively. Isothermal heat treatments were performed at 450 degrees C for times up to 243 h. The hardness evolution of the three materials was found to vary with the overall concentration of the nitrogen. Atom probe field ion microscopy (APFIM) was used to directly detect and quantify the degree of spinodal decomposition in different material conditions. 3-DAP atomic reconstruction clearly illustrate nanoscale variation of iron rich (alpha) and chromium rich (alpha') phases. A longer ageing time produces a coarser microstructure with larger alpha and alpha' domains. Statistical evaluation of APFIM data showed that phase separation was significant already after 1 h of ageing that gradually became more pronounced. Although nanoscale concentration variation was evident, no significant influence of overall nitrogen content on the degree of spinodal decomposition was found.

  9. Associations between informant ratings of personality disorder traits, self-reports of personality, and directly observed behavior.

    Science.gov (United States)

    Kaurin, Aleksandra; Sauerberger, Kyle S; Funder, David C

    2018-03-02

    Diagnoses of personality disorders (PD) must rely on judgments of observers-either clinicians or acquaintances-because personality disorders are primarily defined in terms of maladaptive interpersonal behavior. Little is known, however, about how closely acquaintances' judgments of PD traits relate to self-reports of theoretically relevant Big Five traits or directly observed behavioral outcomes in interpersonal situations. The present study examines associations between judgments of the 10 PD traits provided by close acquaintances, self-reports of PD-relevant Big Five personality traits, and observed interpersonal behaviors across three different three-person laboratory interactions (i.e., unstructured chat, cooperative task, competitive game). The sample consisted of 256 undergraduate students (130 females; M age  = 19.83, SD = 1.25). Four unacquainted observers independently rated participants' behaviors from video recordings. In line with previous work, informant reports of PD traits demonstrate strong convergent validity with relevant self-reported Big Five traits (as identified by Lynam & Widiger, 2001). Directly observed behavior is meaningfully associated with acquaintances' judgments and self-reports of PD-relevant traits, and the associations between these judgments and behavior are strongest for traits associated with histrionic and schizoid PD. Vector correlations between behavioral profiles associated with informant and self-reports show that both assessments have similar behavioral correlates. Associations between PD trait ratings and behavior appeared to differ as a function of gender, with males showing more and stronger correlations. Informants' ratings of PD traits are impressively accurate, converging both with self-reports of relevant traits and directly observed interpersonal behavior. Therefore, a comprehensive understanding of PDs and associated traits can be augmented by information from multiple acquaintances who have the

  10. Observations and modeling of the elastogravity signals preceding direct seismic waves

    Science.gov (United States)

    Vallée, Martin; Ampuero, Jean Paul; Juhel, Kévin; Bernard, Pascal; Montagner, Jean-Paul; Barsuglia, Matteo

    2017-12-01

    After an earthquake, the earliest deformation signals are not expected to be carried by the fastest (P) elastic waves but by the speed-of-light changes of the gravitational field. However, these perturbations are weak and, so far, their detection has not been accurate enough to fully understand their origins and to use them for a highly valuable rapid estimate of the earthquake magnitude. We show that gravity perturbations are particularly well observed with broadband seismometers at distances between 1000 and 2000 kilometers from the source of the 2011, moment magnitude 9.1, Tohoku earthquake. We can accurately model them by a new formalism, taking into account both the gravity changes and the gravity-induced motion. These prompt elastogravity signals open the window for minute time-scale magnitude determination for great earthquakes.

  11. Direct observation of magnon-phonon coupling in yttrium iron garnet

    Science.gov (United States)

    Man, Haoran; Shi, Zhong; Xu, Guangyong; Xu, Yadong; Chen, Xi; Sullivan, Sean; Zhou, Jianshi; Xia, Ke; Shi, Jing; Dai, Pengcheng

    2017-09-01

    The magnetic insulator yttrium iron garnet (YIG) with a ferrimagnetic transition temperature of ˜560 K has been widely used in microwave and spintronic devices. Anomalous features in spin Seeback effect (SSE) voltages have been observed in Pt/YIG and attributed to magnon-phonon coupling. Here, we use inelastic neutron scattering to map out low-energy spin waves and acoustic phonons of YIG at 100 K as a function of increasing magnetic field. By comparing the zero and 9.1 T data, we find that instead of splitting and opening up gaps at the spin wave and acoustic phonon dispersion intersecting points, magnon-phonon coupling in YIG enhances the hybridized scattering intensity. These results are different from expectations of conventional spin-lattice coupling, calling for different paradigms to understand the scattering process of magnon-phonon interactions and the resulting magnon polarons.

  12. First direct observation of time-reversal non-invariance in the neutral-kaon system

    CERN Document Server

    Angelopoulos, Angelos; Aslanides, Elie; Backenstoss, Gerhard; Bargassa, P; Behnke, O; Benelli, A; Bertin, V; Blanc, F; Bloch, P; Carlson, P J; Carroll, M; Cawley, E; Chertok, M B; Danielsson, M; Dejardin, M; Derré, J; Ealet, A; Eleftheriadis, C; Faravel, L; Fetscher, W; Fidecaro, Maria; Filipcic, A; Francis, D; Fry, J; Gabathuler, Erwin; Gamet, R; Gerber, H J; Go, A; Haselden, A; Hayman, P J; Henry-Coüannier, F; Hollander, R W; Jon-And, K; Kettle, P R; Kokkas, P; Kreuger, R; Le Gac, R; Leimgruber, F; Mandic, I; Manthos, N; Marel, Gérard; Mikuz, M; Miller, J; Montanet, François; Müller, A; Nakada, Tatsuya; Pagels, B; Papadopoulos, I M; Pavlopoulos, P; Polivka, G; Rickenbach, R; Roberts, B L; Ruf, T; Santoni, C; Schäfer, M; Schaller, L A; Schietinger, T; Schopper, A; Tauscher, Ludwig; Thibault, C; Touchard, F; Touramanis, C; van Eijk, C W E; Vlachos, S; Weber, P; Wigger, O; Wolter, M; Zavrtanik, D; Zimmerman, D

    1998-01-01

    We report on the first observation of time-reversal symmetry violation through a comparison of the probabilities of $\\bar{K}^0$ transforming into $K^0$ and $K^0$ into $\\bar{K}^0$ as a function of the neutral-kaon eigentime $t$. The comparison is based on the analysis of the neutral-kaon semileptonic decays recorded in the CPLEAR experiment. There, the strangeness of the neutral kaon at time $t=0$ was tagged by the kaon charge in the reaction $p\\bar{p} \\rightarrow K^{\\pm} \\pi^{\\mp} K^0(\\bar{K}^0)$ at rest, whereas the strangeness of the kaon at the decay time $t=\\tau$ was tagged by the lepton charge in the final state. An average decay-rate asymmetry \\begin{equation*} \\langle^{R(\\bar{K}^0_{t=0} \\to e^+\\pi^-\

  13. Direct observation of the lattice sites of implanted manganese in silicon

    CERN Document Server

    Silva, Daniel; Wahl, Ulrich; Martins Correia, Joao; Amorim, Lígia; Decoster, Stefan; Castro Ribeiro Da Silva, Manuel; Da Costa Pereira, Lino Miguel; Esteves De Araujo, Araujo Joao Pedro

    2016-01-01

    Mn-doped Si has attracted significant interest in the context of dilute magnetic semiconductors. We investigated the lattice location of implanted Mn in silicon of different doping types (n, n+ and p+) in the highly dilute regime. Three different lattice sites were identified by means of emission channeling experiments: ideal substitutional sites; sites displaced from bond-centered towards substitutional sites and sites displaced from anti-bonding towards tetrahedral interstitial sites. For all doping types investigated, the substitutional fraction remained below ∼ 30%. We discuss the origin of the observed lattice sites as well as the implications of such structures on the understanding of Mn-doped Si systems.

  14. Direct Observation of the Phenomenology of a Solid Thermal Explosion Using Time-Resolved Proton Radiography

    International Nuclear Information System (INIS)

    Smilowitz, L.; Henson, B. F.; Romero, J. J.; Asay, B. W.; Schwartz, C. L.; Saunders, A.; Merrill, F. E.; Morris, C. L.; Kwiatkowski, K.; Hogan, G.; Nedrow, P.; Murray, M. M.; Thompson, T. N.; McNeil, W.; Rightley, P.; Marr-Lyon, M.

    2008-01-01

    We present a new phenomenology for burn propagation inside a thermal explosion based on dynamic radiography. Radiographic images were obtained of an aluminum cased solid cylindrical sample of a plastic bonded formulation of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine. The phenomenology observed is ignition followed by cracking in the solid accompanied by the propagation of a radially symmetric front of increasing proton transmission. This is followed by a further increase in transmission through the sample, ending after approximately 100 μs. We show that these processes are consistent with the propagation of a convective burn front followed by consumption of the remaining solid by conductive particle burning

  15. Wave-particle energy exchange directly observed in a kinetic Alfvén-branch wave.

    Science.gov (United States)

    Gershman, Daniel J; F-Viñas, Adolfo; Dorelli, John C; Boardsen, Scott A; Avanov, Levon A; Bellan, Paul M; Schwartz, Steven J; Lavraud, Benoit; Coffey, Victoria N; Chandler, Michael O; Saito, Yoshifumi; Paterson, William R; Fuselier, Stephen A; Ergun, Robert E; Strangeway, Robert J; Russell, Christopher T; Giles, Barbara L; Pollock, Craig J; Torbert, Roy B; Burch, James L

    2017-03-31

    Alfvén waves are fundamental plasma wave modes that permeate the universe. At small kinetic scales, they provide a critical mechanism for the transfer of energy between electromagnetic fields and charged particles. These waves are important not only in planetary magnetospheres, heliospheres and astrophysical systems but also in laboratory plasma experiments and fusion reactors. Through measurement of charged particles and electromagnetic fields with NASA's Magnetospheric Multiscale (MMS) mission, we utilize Earth's magnetosphere as a plasma physics laboratory. Here we confirm the conservative energy exchange between the electromagnetic field fluctuations and the charged particles that comprise an undamped kinetic Alfvén wave. Electrons confined between adjacent wave peaks may have contributed to saturation of damping effects via nonlinear particle trapping. The investigation of these detailed wave dynamics has been unexplored territory in experimental plasma physics and is only recently enabled by high-resolution MMS observations.

  16. Wave-Particle Energy Exchange Directly Observed in a Kinetic Alfven-Branch Wave

    Science.gov (United States)

    Gershman, Daniel J.; F-Vinas, Adolfo; Dorelli, John C.; Boardsen, Scott A. (Inventor); Avanov, Levon A.; Bellan, Paul M.; Schwartz, Steven J.; Lavraud, Benoit; Coffey, Victoria N.; Chandler, Michael O.; hide

    2017-01-01

    Alfven waves are fundamental plasma wave modes that permeate the universe. At small kinetic scales they provide a critical mechanism for the transfer of energy between electromagnetic fields and charged particles. These waves are important not only in planetary magnetospheres, heliospheres, and astrophysical systems, but also in laboratory plasma experiments and fusion reactors. Through measurement of charged particles and electromagnetic fields with NASAs Magnetospheric Multiscale (MMS) mission, we utilize Earths magnetosphere as a plasma physics laboratory. Here we confirm the conservative energy exchange between the electromagnetic field fluctuations and the charged particles that comprise an undamped kinetic Alfven wave. Electrons confined between adjacent wave peaks may have contributed to saturation of damping effects via non-linear particle trapping. The investigation of these detailed wave dynamics has been unexplored territory in experimental plasma physics and is only recently enabled by high-resolution MMS observations.

  17. Direct observation of densification and grain growth in a W--Ni alloy

    International Nuclear Information System (INIS)

    Riegger, H.; Pask, J.A.; Exner, H.E.

    1979-04-01

    Densification and grain growth in a tungsten--nickel alloy containing 32 vol % of liquid at 1550 0 C were studied by conventional methods aided by hot stage scanning electron microscopy and cinematography. This technique yields important additional qualitative information on the mechanisms. Two stages can be discerned. In stage 1, essentially complete pore elimination, rapid grain growth and adjustment of microstructural geometry take place. In the second stage, microstructure coarsening occurs which is characterized by geometric similarity. Columnar grain growth at the surface is observed due to squeezing out of Ni--W liquid, flooding of surface grains and fast evaporation of the Ni. The driving forces for these processes are discussed showing that a high ratio of grain boundary energy to liquid surface energy is essential. A W--Cu alloy with 32 vol % liquid at 1100 0 C did not show any grain growth due to essentially no solubility of W in Cu at this temperature

  18. Direct Observation of Strong Ion Coupling in Laser-Driven Shock-Compressed Targets

    International Nuclear Information System (INIS)

    Ravasio, A.; Benuzzi-Mounaix, A.; Loupias, B.; Ozaki, N.; Rabec le Gloahec, M.; Koenig, M.; Gregori, G.; Daligault, J.; Delserieys, A.; Riley, D.; Faenov, A. Ya.; Pikuz, T. A.

    2007-01-01

    In this Letter we report on a near collective x-ray scattering experiment on shock-compressed targets. A highly coupled Al plasma was generated and probed by spectrally resolving an x-ray source forward scattered by the sample. A significant reduction in the intensity of the elastic scatter was observed, which we attribute to the formation of an incipient long-range order. This speculation is confirmed by x-ray scattering calculations accounting for both electron degeneracy and strong coupling effects. Measurements from rear side visible diagnostics are consistent with the plasma parameters inferred from x-ray scattering data. These results give the experimental evidence of the strongly coupled ionic dynamics in dense plasmas

  19. Direct observation of phase transition of GeSbTe thin films by Atomic Force Microscope

    Energy Technology Data Exchange (ETDEWEB)

    Yang Fei [National Laboratory of Solid State Microstructures and Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials Sciences and Technology, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093 (China); Xu Ling, E-mail: xuling@nju.edu.cn [National Laboratory of Solid State Microstructures and Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials Sciences and Technology, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093 (China); Zhang Rui; Geng Lei; Tong Liang; Xu Jun [National Laboratory of Solid State Microstructures and Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials Sciences and Technology, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093 (China); Su Weining; Yu Yao [National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093 (China); Ma Zhongyuan; Chen Kunji [National Laboratory of Solid State Microstructures and Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials Sciences and Technology, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093 (China)

    2012-10-01

    Graphical abstract: Nano-sized marks on GST thin film were fabricated using Conductive-AFM (Atomic Force Microscope). The AFM morphology images show that the marks are ablated at the center and a raised ring surrounding it. Highlights: Black-Right-Pointing-Pointer Microstructure of GeSbTe thin films was characterized by XRD and AFM. Black-Right-Pointing-Pointer Annealing and applying electrical field can induce crystallization on thin film. Black-Right-Pointing-Pointer Conductive-AFM was used to modify the surface of GeSbTe thin film. - Abstract: GeSbTe (GST) thin films were deposited on quartz substrates using electron beam evaporation system and then annealed in nitrogen atmosphere at different temperatures, ranging from 20 Degree-Sign C to 300 Degree-Sign C. X-ray diffraction (XRD) and Atomic Force microscope (AFM) measurements were used to characterize the as-deposited and post-annealed thin films. Annealing treatment was found to induce changes on microstructure, surface roughness and grain size, indicating that with the increase of annealing temperature, the amorphous GST films first changed to face-centered-cubic (fcc) phase and then the stable hexagonal (hex) phase. Meanwhile, conductive-AFM (C-AFM) was used to produce crystallized GST dots on thin films. I-V spectroscopy results show that GST films can switch from amorphous state to crystalline state at threshold voltage. After switching, I-V curve exhibits ohmic characteristic, which is usually observed in crystallized GST films. By applying repeated I-V spectroscopies on the thin films, crystallized nuclei were observed. As the times of I-V spectroscopies increases, the area of written dots increases, and the center of the mark begin to ablate. The AFM images show that the shape of marks is an ablated center with a raised ring surrounding it.

  20. Direct observation of Medicaid beneficiary attempts to fill prescriptions for nicotine replacement medications.

    Science.gov (United States)

    Richter, Kimber P; Shergina, Elena; Grodie, Amanda; Massey, Justin K; Ellerbeck, Edward F; Applegate, Amanda; Faseru, Babalola

    2018-04-21

    Although many states have expanded Medicaid coverage of cessation medications, utilization remains low. Anecdotal reports suggest that beneficiaries are at times denied coverage of cessation medications at the pharmacy counter. We conducted an observational community-wide case study of Medicaid beneficiary attempts to fill over-the-counter nicotine replacement therapy at pharmacies. We recruited tobacco-using beneficiaries from a Federally Qualified Health Center, whose providers wrote paper prescriptions for nicotine patches. Study staff escorted beneficiaries to all eligible pharmacies (n = 18) in a Midwestern community to observe fill attempts. Study staff recorded encounters via smartphone into a secure database on a university server. Seven of 18 pharmacies (39%) did not fill the prescription on the day of the attempt. Of these, 6 offered to order the patch for pick-up at a later date. All (4/4) chain pharmacies filled the prescription; 2/3 mass merchant pharmacies failed to fill. Combining successful same-day fills with offers to order for pick-up, 17/18 (94%) would ultimately have been able to obtain patches. This pilot study found that many beneficiaries left pharmacies without a prescription in hand. Successful same-day fills varied markedly by store type. For people with low incomes, transportation presents a major barrier for delayed pick-up. In addition, delays can fuel ambivalence toward quitting. Future research based on this pilot study might address whether patients who fail to secure a same-day prescription ever fill the prescription and, if not, the degree to which this barrier contributes to success or failure in quitting. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  1. Direct observation of grafting interlayer phosphate in Mg/Al layered double hydroxides

    International Nuclear Information System (INIS)

    Shimamura, Akihiro; Kanezaki, Eiji; Jones, Mark I.; Metson, James B.

    2012-01-01

    The grafting of interlayer phosphate in synthetic Mg/Al layered double hydroxides with interlayer hydrogen phosphate (LDH-HPO 4 ) has been studied by XRD, TG/DTA, FT-IR, XPS and XANES. The basal spacing of crystalline LDH-HPO 4 decreases in two stages with increasing temperature, from 1.06 nm to 0.82 nm at 333 K in the first transition, and to 0.722 nm at 453 K in the second. The first stage occurs due to the loss of interlayer water and rearrangement of the interlayer HPO 4 2− . In the second transition, the interlayer phosphate is grafted to the layer by the formation of direct bonding to metal cations in the layer, accompanied by a change in polytype of the crystalline structure. The grafted phosphate becomes immobilized and cannot be removed by anion-exchange with 1-octanesulfonate. The LDH is amorphous at 743 K but decomposes to Mg 3 (PO 4 ) 2 , AlPO 4 , MgO and MgAl 2 O 4 after heated to 1273 K. - Graphical abstract: The cross section of the synthetic Mg, Al layered double hydroxides in Phase 1, with interlayer hydrogen phosphate Phase 2, and with grafted phosphate, Phase 3. Highlights: ► The grafting of hydrogen phosphate intercalated Mg/Al-LDH has been studied. ► The basal spacing of crystalline LDH-HPO 4 decreases in two stages with increasing temperature. ► The first decrease is due to loss of interlayer water, the second is attributed to phosphate grafting. ► The grafted interlayer phosphate becomes immobilized and cannot be removed by anion-exchange.

  2. Parameter estimation method that directly compares gravitational wave observations to numerical relativity

    Science.gov (United States)

    Lange, J.; O'Shaughnessy, R.; Boyle, M.; Calderón Bustillo, J.; Campanelli, M.; Chu, T.; Clark, J. A.; Demos, N.; Fong, H.; Healy, J.; Hemberger, D. A.; Hinder, I.; Jani, K.; Khamesra, B.; Kidder, L. E.; Kumar, P.; Laguna, P.; Lousto, C. O.; Lovelace, G.; Ossokine, S.; Pfeiffer, H.; Scheel, M. A.; Shoemaker, D. M.; Szilagyi, B.; Teukolsky, S.; Zlochower, Y.

    2017-11-01

    We present and assess a Bayesian method to interpret gravitational wave signals from binary black holes. Our method directly compares gravitational wave data to numerical relativity (NR) simulations. In this study, we present a detailed investigation of the systematic and statistical parameter estimation errors of this method. This procedure bypasses approximations used in semianalytical models for compact binary coalescence. In this work, we use the full posterior parameter distribution for only generic nonprecessing binaries, drawing inferences away from the set of NR simulations used, via interpolation of a single scalar quantity (the marginalized log likelihood, ln L ) evaluated by comparing data to nonprecessing binary black hole simulations. We also compare the data to generic simulations, and discuss the effectiveness of this procedure for generic sources. We specifically assess the impact of higher order modes, repeating our interpretation with both l ≤2 as well as l ≤3 harmonic modes. Using the l ≤3 higher modes, we gain more information from the signal and can better constrain the parameters of the gravitational wave signal. We assess and quantify several sources of systematic error that our procedure could introduce, including simulation resolution and duration; most are negligible. We show through examples that our method can recover the parameters for equal mass, zero spin, GW150914-like, and unequal mass, precessing spin sources. Our study of this new parameter estimation method demonstrates that we can quantify and understand the systematic and statistical error. This method allows us to use higher order modes from numerical relativity simulations to better constrain the black hole binary parameters.

  3. Direct observations of the 3D pore network of a Callovo-Oxfordian clay-stone

    International Nuclear Information System (INIS)

    Robinet, J.C.; Talandier, J.; Davy, C.A.; Ghayaza, M.; Skoczylas, F.; Troadec, D.; Sardini, P.

    2012-01-01

    Document available in extended abstract form only. Long term deep underground storage of radioactive nuclear waste is planned in the East of France within an argillaceous rock layer (the host rock), also called argillite, situated at ca. 450-500 m depth. Andra, the French national agency for nuclear waste management, is in charge of assessing the feasibility, the safety and the performance of this underground disposal. The drilling of storage tunnels generates an Excavated Damaged Zone (EDZ), where argillite is macro-cracked in various locations. This requires strengthening by different means, e.g. shotcrete or pre-fabricated concrete arches. It is also expected that underground water seepage will contribute to argillite sealing: mainly self-sealing, and sealing at the interface with concrete. Sealing phenomena include crystalline swelling of smectitic clay components of argillite and inter-particle swelling of clay minerals due to osmosis mechanisms. Small scale pores and mineral organisation of the COx clay-stone are widely acknowledged to control transfer properties of water, gas and varied solutes. In order to assess these properties, the COx small-scale structure has been imaged down to micrometric resolution by various means, including classical Scanning Electron Microscopy (SEM), X-ray computed microtomography and autoradiography. To go further into pore and mineral characterisation of COx clay-stone, the following investigations are currently under way: (i) acquiring/quantifying the 3D geometry of the pore network of undisturbed COx with a nano-metric resolution and (ii) imaging/quantifying the small-scale (mm-nm) structure of self-sealed volumes. The FIB (Focused Ion Beam) /SEM technique allows performing 3D observations of solid volumes of ca. a few microns, with a resolution of about ten nanometers, by acquiring and computing regularly spaced 2D SEM images. This technique provides quantification of the 3D spatial distribution mainly of macro- and meso

  4. Algebraic methods for a direct calculus of observables in the theory of nuclear band structure

    International Nuclear Information System (INIS)

    Klein, A.

    1983-01-01

    The basis for much of the present understanding of nuclear structure derives from the study of mean field approximations (such as Hartree-Fock or Bardeen-Cooper-Schrieffer) and of small deviations from the mean field (random phase approximation and the cranking model). This review is devoted to the study of a theoretical framework for these and other approximations. The approach is the application of Heisenberg matrix mechanics to the nuclear many-body problem. It utilizes a calculus for matrix elements of suitably chosen simple operators between exact eigenstates of the Hamiltonian. In the first class of investigations, in which single fermion operators were chosen, one ends with a theory providing a justification for and generalization of various core-particle coupling models and a basis for nuclear field theory. In a further group of studies of matrix elements of multipole and/or pair operators, the collective behavior of even nuclei can be examined, divorced from their coupling to neighboring odd nuclei. Various investigations carried out over two decades are described. A common theoretical thread is that the calculations are done uniformly in fermion shell model space in a representation in which the Hamiltonian is diagonal. New developments which may alter these considerations profoundly by enlarging the framework in which they may be carried out are envisaged. (author)

  5. Direct observation and determination of the mechanisms governing mobility of asbestos in porous media

    Science.gov (United States)

    Seiphoori, A.; Ortiz, C. P.; Jerolmack, D. J.

    2017-12-01

    Transport of asbestos through soil by groundwater is typically considered to be negligible. There are indications, however, that under some conditions of pore-water/soil chemistry asbestos may become mobile, implying that buried contaminants could migrate from a disposal site and surface elsewhere. Shape, size and surface charge may influence the physical and chemical interactions of colloids with the soil matrix, and asbestos consists of elongated particles with different size and unique surface charge properties. Although chemical factors such as pH and ionic strength of pore water may affect the transport properties, the presence of dissolved organic carbon (DOC) has been identified to remarkably enhance the mobility of colloids including asbestos. To date, there is no explanation for how the presence of DOC may facilitate the mobilization of asbestos in soil - mainly because the soil medium has been treated as a black box without the possibility of observing particles within the matrix. Here, we investigated the mobility of chrysotile asbestos particles ( 10 um long) in porous media by developing a flow cell with an optically-transparent porous medium composed of granules of a refractive-index matched material. This enabled us to observe and track the particles within the water-saturated porous medium using in situ microscopy. The aqueous suspension of asbestos fibers was passed through this artificial soil, while the physical and chemical interaction of asbestos particles with the medium and their pore-scale distribution were analyzed. We studied the effects of changing solution chemistry (e.g., ionic strength, pH, and DOC content) on transport, attachment and aggregation of chrysotile particles. Experiments revealed a novel mechanism where the DOC-associated nanoparticles attach to chrysotile fibers by an electrostatic attraction, which facilitates their mobilization through the porous medium while modulating aggregation among fibers. Although pH and ionic

  6. Direct observation of organic layer growth by dynamic spectro-microscopy using high-brilliance synchrotron

    International Nuclear Information System (INIS)

    Umbach, E.

    2004-01-01

    It was always the dream of scientists to watch microscopic objects directly on an atomic scale, to follow their dynamical behaviour, and to know everything about them, i.e. to get as much spectroscopic information as possible. While instruments have become available which may fulfill two of these wishes simultaneously, it is much more difficult to get all three at once. The development of so called spectro-microscopes which operate at 3rd generation synchrotron sources nourishes the hope that this dream will become true in the near future. The talk intends to show how much can be learned about organic thin films and interfaces if high-brilliance synchrotron radiation is combined with new instruments, for instance a high energy resolution beamline and a high-spatial resolution spectro-microscope. While the former is standard technology of today, the latter is a new development, combining brilliant undulator radiation of variable polarization with a specially developed, energy-filtered low energy electron microscope. First, it will be shown that many new details about the electronic structure of organic materials and their interaction with one another or with an interface can be obtained using high-resolution photoemission and x-ray absorption. For instance, from a careful analysis of the fine structure of photoemission spectra one can derive details about the interface bonding, about the interaction between molecules, and about the dynamic response of the molecular system upon creation of a core hole. Or, from a careful analysis of the fine structure of high resolution x-ray absorption spectra one gets insight into the intermolecular interaction, the coupling between electronic and vibronic excitations, and even about the shapes of potential curves. Second, the dynamic growth of highly-ordered organic thin films will be followed as a function of molecule and preparation conditions. The formation of islands, the inner structure of organic crystallites, diffusion

  7. Ion cyclotron waves: Direct compariosn between ground-based measurements and observations in the source region

    International Nuclear Information System (INIS)

    Perraut, S.; Gendrin, R.; Roux, A.; de Villedary, C.

    1984-01-01

    Simultaneous measurements of ion cyclotron waves (ICW's) were performed on GEOS spacecraft and in the vicinity of their magnetic footprints with the French Mobile station. The detailed comparison between the two sets of data shown that while ICW's having F + gyrofrequency at the equator, generally propagate to the ground, only 50% of those generated above F/sub He/ can reach the ground station. It is shown that these results are in good agreement with the conclusions that Rauch and Roux [1982] drew on the basis of measurements reported by Young et al 1981]. In an He + -rich plasma, ICW's with F>F/sub He/ suffer a reflection where the frequency locally matches the local bi-ion hybrid frequency. We extend the calculations of Rauch and Roux and calculate, as a function of the He + concentration, the tunneling of ICW's through the stopband induced by the presence of minor He + ions. It is shown that the transmission coefficient strongly depends upon the wave frequency for a given He + abundance ratio. The results obtained are shown to be supported by existing observations

  8. Direct observations of rock moisture, a hidden component of the hydrologic cycle.

    Science.gov (United States)

    Rempe, Daniella M; Dietrich, William E

    2018-03-13

    Recent theory and field observations suggest that a systematically varying weathering zone, that can be tens of meters thick, commonly develops in the bedrock underlying hillslopes. Weathering turns otherwise poorly conductive bedrock into a dynamic water storage reservoir. Infiltrating precipitation typically will pass through unsaturated weathered bedrock before reaching groundwater and running off to streams. This invisible and difficult to access unsaturated zone is virtually unexplored compared with the surface soil mantle. We have proposed the term "rock moisture" to describe the exchangeable water stored in the unsaturated zone in weathered bedrock, purposely choosing a term parallel to, but distinct from, soil moisture, because weathered bedrock is a distinctly different material that is distributed across landscapes independently of soil thickness. Here, we report a multiyear intensive campaign of quantifying rock moisture across a hillslope underlain by a thick weathered bedrock zone using repeat neutron probe measurements in a suite of boreholes. Rock moisture storage accumulates in the wet season, reaches a characteristic upper value, and rapidly passes any additional rainfall downward to groundwater. Hence, rock moisture storage mediates the initiation and magnitude of recharge and runoff. In the dry season, rock moisture storage is gradually depleted by trees for transpiration, leading to a common lower value at the end of the dry season. Up to 27% of the annual rainfall is seasonally stored as rock moisture. Significant rock moisture storage is likely common, and yet it is missing from hydrologic and land-surface models used to predict regional and global climate.

  9. Direct observations of rock moisture, a hidden component of the hydrologic cycle

    Science.gov (United States)

    Rempe, Daniella M.; Dietrich, William E.

    2018-03-01

    Recent theory and field observations suggest that a systematically varying weathering zone, that can be tens of meters thick, commonly develops in the bedrock underlying hillslopes. Weathering turns otherwise poorly conductive bedrock into a dynamic water storage reservoir. Infiltrating precipitation typically will pass through unsaturated weathered bedrock before reaching groundwater and running off to streams. This invisible and difficult to access unsaturated zone is virtually unexplored compared with the surface soil mantle. We have proposed the term “rock moisture” to describe the exchangeable water stored in the unsaturated zone in weathered bedrock, purposely choosing a term parallel to, but distinct from, soil moisture, because weathered bedrock is a distinctly different material that is distributed across landscapes independently of soil thickness. Here, we report a multiyear intensive campaign of quantifying rock moisture across a hillslope underlain by a thick weathered bedrock zone using repeat neutron probe measurements in a suite of boreholes. Rock moisture storage accumulates in the wet season, reaches a characteristic upper value, and rapidly passes any additional rainfall downward to groundwater. Hence, rock moisture storage mediates the initiation and magnitude of recharge and runoff. In the dry season, rock moisture storage is gradually depleted by trees for transpiration, leading to a common lower value at the end of the dry season. Up to 27% of the annual rainfall is seasonally stored as rock moisture. Significant rock moisture storage is likely common, and yet it is missing from hydrologic and land-surface models used to predict regional and global climate.

  10. Direct observation of two dimensional trace gas distributions with an airborne Imaging DOAS instrument

    Directory of Open Access Journals (Sweden)

    K.-P. Heue

    2008-11-01

    Full Text Available In many investigations of tropospheric chemistry information about the two dimensional distribution of trace gases on a small scale (e.g. tens to hundreds of metres is highly desirable. An airborne instrument based on imaging Differential Optical Absorption Spectroscopy has been built to map the two dimensional distribution of a series of relevant trace gases including NO2, HCHO, C2H2O2, H2O, O4, SO2, and BrO on a scale of 100 m.

    Here we report on the first tests of the novel aircraft instrument over the industrialised South African Highveld, where large variations in NO2 column densities in the immediate vicinity of several sources e.g. power plants or steel works, were measured. The observed patterns in the trace gas distribution are interpreted with respect to flux estimates, and it is seen that the fine resolution of the measurements allows separate sources in close proximity to one another to be distinguished.

  11. Direct observation of children's preferences and activity levels during interactive and online electronic games.

    Science.gov (United States)

    Sit, Cindy H P; Lam, Jessica W K; McKenzie, Thomas L

    2010-07-01

    Interactive electronic games have recently been popularized and are believed to help promote children's physical activity (PA). The purpose of the study was to examine preferences and PA levels during interactive and online electronic games among overweight and nonoverweight boys and girls. Using a modification of the SOFIT, we systematically observed 70 Hong Kong Chinese children (35 boys, 35 girls; 50 nonoverweight, 20 overweight), age 9 to 12 years, during 2 60-minute recreation sessions and recorded their game mode choices and PA levels. During Session One children could play either an interactive or an online electronic bowling game and during Session Two they could play an interactive or an online electronic running game. Children chose to play the games during 94% of session time and split this time between interactive (52%) and online (48%) versions. They engaged in significantly more moderate-to-vigorous physical activity (MVPA) during interactive games than their online electronic versions (70% vs. 2% of game time). Boys and nonoverweight children expended relatively more energy during the interactive games than girls and overweight children, respectively. New-generation interactive games can facilitate physical activity in children, and given the opportunity children may select them over sedentary versions.

  12. Strengthening Purity: Moral Purity as a Mediator of Direct and Extended Cross-Group Friendships on Sexual Prejudice.

    Science.gov (United States)

    Vezzali, Loris; Brambilla, Marco; Giovannini, Dino; Paolo Colucci, Francesco

    2017-01-01

    The present research investigated whether enhanced perceptions of moral purity drive the effects of intergroup cross-group friendships on the intentions to interact with homosexuals. High-school students (N = 639) reported their direct and extended cross-group friendships with homosexuals as well as their beliefs regarding the moral character of the sexual minority. Participants further reported their desire to interact with homosexuals in the future. Results showed that both face-to-face encounters and extended contact with homosexuals increased their perceived moral purity, which in turn fostered more positive behavioral intentions. Results further revealed the specific role of moral purity in this sense, as differential perceptions along other moral domains (autonomy and community) had no mediation effects on behavioral tendencies toward homosexuals. The importance of these findings for improving intergroup relations is discussed, together with the importance of integrating research on intergroup contact and morality.

  13. Pulse advancement and delay in an integrated optical two-port ring-resonator circuit: direct experimental observations

    NARCIS (Netherlands)

    Uranus, H.P.; Zhuang, L.; Roeloffzen, C.G.H.; Hoekstra, Hugo

    We report experimental observations of the negative-group-velocity (v_g) phenomenon in an integrated-optical two-port ring-resonator circuit. We demonstrate that when the v_g is negative, the (main) peak of output pulse appears earlier than the peak of a reference pulse, while for a positive v_g,

  14. Direct observation of the formation of silver precipitations by means of electron diffraction

    International Nuclear Information System (INIS)

    Benz, V.; Ostwald, R.; Weil, K.G.

    1976-01-01

    Thin films (20-1,000 A) of copper (I)-, silver, and lead(II)-halides were prepared by evaporation onto silver (III), gold (III), and PbTe (III)-surfaces. These films were irradiated in vacuo with 40 kV-electrons, in some cases also with the light of a Xenon-lamp. At the same time the diffraction pattern, produced by the electron beam at glancing incidence, was observed and registered photographically. Silver precipitates could be detected by their diffraction pattern, when the crystallites had grown to a size of about 50 A. From all materials investigated silveriodide showed maximum sensitivity. The precipitates formed show no orientation with respect to the host crystal. From the temperature dependence of the sensitivity an activation energy of 0.12 eV can be deduced leading to interstitial ion migration as rate determining step. Pure silverchloride can not been radiolyzed by 40 kV-electrons. After doping it with 0.3 mol% CaCl 2 or MgCl 2 it becomes very sensitive. The precipitate showes orientation with respect to the host lattice. Also pure CuJ is resistant against the electron beam. Mixed crystals (Ag, Cu)J with xsub(AgJ) > 0.5 behave similar as pure AgJ. Pb(II)-halides show no sensitivity, but the compounds AgBr x 2 PbBr 2 and 5 AgJ x PbJ 2 are readily radiolyzed, forming polycrystalline silver precipitates. The mechanism of radiolysis, its dependency on temperature and film thickness is discussed. (orig.) [de

  15. Direct observations of seasonal exchange through the Bab el Mandab Strait

    Science.gov (United States)

    Murray, Stephen P.; Johns, William

    The exchange flow between the Red Sea and the Gulf of Aden-Indian Ocean through the Bab el Mandab Strait was measured continuously for 10 months, June 1995-March 1996. ADCP and temperature-salinity chain moorings allow an unprecedented look at the magnitude and seasonal evolution of the inflow layer from the Gulf of Aden, and the high salinity outflow layer from the Red Sea. The timing, structure, and evolution of the summer season mid-depth intrusion of cold, low salinity water into the Red Sea from the Gulf of Aden is measured for the complete intrusion cycle of 1995. We unexpectedly find the deep outflow still strong in June 1995, with speeds of 0.6 m/sec and transport of 0.4 Sv (1 Sv = 106 m³/sec). From July to mid-September, the deep outflow persists but is attenuated to speeds of 0.2 m/sec and transport of 0.05 Sv. The dominant summer feature, the cold low salinity intermediate layer intrusion, persists for 3 months, occupies 70% of the water column in the Strait and carries approximately 1.7 × 1012 m³ of cold nutrient-rich water into the Red Sea. The winter regime begins in mid-September, is fully developed by early November, and continues to the end of our first observation interval in March 1996. Speeds in the lower layer are 0.8-1.0 m/sec and 0.4-0.6 m/sec in the upper layer. At maximum exchange in mid-February, outflow transport reaches 0.7 Sv. Ubiquitous oscillations in current and salinity at synoptic and intraseasonal periods appear closely related to fluctuations in the along-channel wind forcing and perhaps to coastally-trapped waves.

  16. Merging LIDAR digital terrain model with direct observed elevation points for urban flood numerical simulation

    Science.gov (United States)

    Arrighi, Chiara; Campo, Lorenzo

    2017-04-01

    In last years, the concern about the economical and lives loss due to urban floods has grown hand in hand with the numerical skills in simulating such events. The large amount of computational power needed in order to address the problem (simulating a flood in a complex terrain such as a medium-large city) is only one of the issues. Among them it is possible to consider the general lack of exhaustive observations during the event (exact extension, dynamic, water level reached in different parts of the involved area), needed for calibration and validation of the model, the need of considering the sewers effects, and the availability of a correct and precise description of the geometry of the problem. In large cities the topographic surveys are in general available with a number of points, but a complete hydraulic simulation needs a detailed description of the terrain on the whole computational domain. LIDAR surveys can achieve this goal, providing a comprehensive description of the terrain, although they often lack precision. In this work an optimal merging of these two sources of geometrical information, measured elevation points and LIDAR survey, is proposed, by taking into account the error variance of both. The procedure is applied to a flood-prone city over an area of 35 square km approximately starting with a DTM from LIDAR with a spatial resolution of 1 m, and 13000 measured points. The spatial pattern of the error (LIDAR vs points) is analysed, and the merging method is tested with a series of Jackknife procedures that take into account different densities of the available points. A discussion of the results is provided.

  17. The first direct observation of hydrogen trapping sites in TiC precipitation-hardening steel through atom probe tomography

    International Nuclear Information System (INIS)

    Takahashi, Jun; Kawakami, Kazuto; Kobayashi, Yukiko; Tarui, Toshimi

    2010-01-01

    For the first time ever, atomic-scale direct observation of deuterium atoms trapping at nano-sized titanium carbide (TiC) precipitates in steel was successfully achieved using atom probe tomography (APT). Deuterium gas charging into the needle specimen and subsequently quenching were conducted in our designed chamber attached to three-dimensional atom probe (3DAP). The deuterium atoms were definitely observed on the broad surface of TiC platelets, which indicated that the broad interface between the matrix and TiC was the main trapping site.

  18. Combined Flux Observer With Signal Injection Enhancement for Wide Speed Range Sensorless Direct Torque Control of IPMSM Drives

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Andreescu, G.-D.; Pitic, C.I.

    2008-01-01

    voltage-current model with PI compensator for low-speed operations. As speed increases, the observer switches gradually to a PI compensated closed-loop voltage model, which is solely used at high speeds. High-frequency rotating-voltage injection with a single D-module bandpass vector filter and a phase......This paper proposes a motion-sensorless control system using direct torque control with space vector modulation for interior permanent magnet synchronous motor (IPMSM) drives, for wide speed range operation, including standstill. A novel stator flux observer with variable structure uses a combined...

  19. A green non-acid-catalyzed process for direct N=N-C group formation: comprehensive study, modeling, and optimization.

    Science.gov (United States)

    Khakyzadeh, Vahid; Zolfigol, Mohammad Ali; Derakhshan-Panah, Fatemeh; Jafarian, Majid; Miri, Mir Vahid; Gilandoust, Maryam

    2018-01-04

    The aim of this work is to introduce, model, and optimize a new non-acid-catalyzed system for a direct N[Formula: see text]N-C bond formation. By reacting naphthols or phenol with anilines in the presence of the sodium nitrite as nitrosonium ([Formula: see text] source and triethylammonium acetate (TEAA), a N[Formula: see text]N-C group can be formed in non-acid media. Modeling and optimization of the reaction conditions were investigated by response surface method. Sodium nitrite, TEAA, and water were chosen as variables, and reaction yield was also monitored. Analysis of variance indicates that a second-order polynomial model with F value of 35.7, a P value of 0.0001, and regression coefficient of 0.93 is able to predict the response. Based on the model, the optimum process conditions were introduced as 2.2 mmol sodium nitrite, 2.2 mL of TEAA, and 0.5 mL [Formula: see text] at room temperature. A quadratic (second-order) polynomial model, by analysis of variance, was able to predict the response for a direct N=N-C group formation. Predicted response values were in good agreement with the experimental values. Electrochemistry studies were done to introduce new Michael acceptor moieties. Broad scope, high yields, short reaction time, and mild conditions are some advantages of the presented method.

  20. C-H Activation and Alkyne Annulation via Automatic or Intrinsic Directing Groups: Towards High Step Economy.

    Science.gov (United States)

    Zheng, Liyao; Hua, Ruimao

    2018-06-01

    Direct transformation of carbon-hydrogen bond (C-H) has emerged to be a trend for construction of molecules from building blocks with no or less prefunctionalization, leading high atom and step economy. Directing group (DG) strategy is widely used to achieve higher reactivity and selectivity, but additional steps are usually needed for installation and/or cleavage of DGs, limiting step economy of the overall transformation. To meet this challenge, we proposed a concept of automatic DG (DG auto ), which is auto-installed and/or auto-cleavable. Multifunctional oxime and hydrazone DG auto were designed for C-H activation and alkyne annulation to furnish diverse nitrogen-containing heterocycles. Imidazole was employed as an intrinsic DG (DG in ) to synthesize ring-fused and π-extended functional molecules. The alkyne group in the substrates can also be served as DG in for ortho-C-H activation to afford carbocycles. In this account, we intend to give a review of our progress in this area and brief introduction of other related advances on C-H functionalization using DG auto or DG in strategies. © 2018 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Evaluation of Teaching Methods in Mass CPCR Training in Different Groups of the Society, an Observational Study.

    Science.gov (United States)

    Hasani, Hamed; Bahrami, Mojtaba; Malekpour, Abdorrasoul; Dehghani, Mohammadreza; Allahyary, Elaheh; Amini, Mitra; Abdorahimi, Mehdi; khani, Sara; Kalantari Meibodi, Mohammad; Kojuri, Javad

    2015-05-01

    To determine the efficacy of different methods of cardiopulmonary resuscitation (CPCR) training in 3 different groups of the society. In a prospective and observational study of 2000 individuals in 3 different groups including G1, G2, and G3 4 different protocols of CPCR training were applied and their efficacy was compared between the groups. Also, 12 months after the study course, 460 participants from 3 groups were asked to take apart in a theoretical and practical examination to evaluate the long-term efficacy of the 4 protocols. Among 2000 individuals took a parted in the study, 950 (47.5%) were G1, 600 (30%) were G2, and 450 (22.5%) were G3. G1 in 4 groups were 2.37 and 2.65 times more successful in pretest theoretical and 2.61 and 18.20 times more successful in practical examinations compared with G2 and G3 and gained highest improvement in CPCR skills. Other groups also showed significantly improved CPCR skills. Comparison of different methods of CPCR learning showed that the workshop using interactive lecture as well as human model, educational film, and reference CPCR book has the highest efficacy in all groups. This protocol of CPCR training showed more efficacy in long-term postdelayed evaluation. On the contrary, medical students had better long-term outcomes from the course. Although G1 and G2 obtained better results in learning CPCR skills, in G3 also the theoretical and practical knowledge were improved significantly. This course increased confidence for doing CPCR in all groups of the study. Considering that the most of the bystanders at emergency states are general population, training this group of the society and increasing their confidence about performing CPCR can be so effective and lifesaving at emergency states. (Clinical trial. Gov registration: NCT02120573).

  2. ARCADO - Adding random case analysis to direct observation in workplace-based formative assessment of general practice registrars.

    Science.gov (United States)

    Ingham, Gerard; Fry, Jennifer; Morgan, Simon; Ward, Bernadette

    2015-12-10

    Workplace-based formative assessments using consultation observation are currently conducted during the Australian general practice training program. Assessment reliability is improved by using multiple assessment methods. The aim of this study was to explore experiences of general practice medical educator assessors and registrars (trainees) when adding random case analysis to direct observation (ARCADO) during formative workplace-based assessments. A sample of general practice medical educators and matched registrars were recruited. Following the ARCADO workplace assessment, semi-structured qualitative interviews were conducted. The data was analysed thematically. Ten registrars and eight medical educators participated. Four major themes emerged - formative versus summative assessment; strengths (acceptability, flexibility, time efficiency, complementarity and authenticity); weaknesses (reduced observation and integrity risks); and contextual factors (variation in assessment content, assessment timing, registrar-medical educator relationship, medical educator's approach and registrar ability). ARCADO is a well-accepted workplace-based formative assessment perceived by registrars and assessors to be valid and flexible. The use of ARCADO enabled complementary insights that would not have been achieved with direct observation alone. Whilst there are some contextual factors to be considered in its implementation, ARCADO appears to have utility as formative assessment and, subject to further evaluation, high-stakes assessment.

  3. Ordered self-assembled monolayers terminated with different chemical functional groups direct neural stem cell linage behaviours

    International Nuclear Information System (INIS)

    Yao, Shenglian; Liu, Xi; He, Jin; Wang, Xiumei; Wang, Ying; Cui, Fu-Zhai

    2016-01-01

    Neural stem cells (NSCs) have been a promising candidate for stem cell-based nerve tissue regeneration. Therefore, the design of idea biomaterials that deliver precise regulatory signals to control stem cell fate is currently a crucial issue that depends on a profound understanding of the interactions between NSCs with the surrounding micro-environment. In this work, self-assembled monolayers of alkanethiols on gold with different chemical groups, including hydroxyl (−OH), amino (−NH 2 ), carboxyl (−COOH) and methyl (−CH 3 ), were used as a simple model to study the effects of surface chemistry on NSC fate decisions. Contact angle measurement and x-ray photoelectron spectroscopy (XPS) examination implied that all types of alkanethiols self-assembled on gold into a close-packed phase structure with similar molecular densities. In this study, we evaluated NSC adhesion, migration and differentiation in response to different chemical functional groups cultured under serum-free conditions. Our studies showed that NSCs exhibited certain phenotypes with extreme sensitivity to surface chemical groups. Compared with other functional groups, the SAMs with hydroxyl end-groups provided the best micro-environment in promoting NSC migration and maintaining an undifferentiated or neuronal differentiation state.  −NH 2 surfaces directed neural stem cells into astrocytic lineages, while NSCs on  −COOH and  −CH 3 surfaces had a similar potency to differentiate into three nerve lineages. To further investigate the possible signaling pathway, the gene expression of integrin β1 and β4 were examined. The results indicated that a high expression of β1 integrin would probably have a tight correlation with the expression of nestin, which implied the stemness of NSCs, while β4 integrin seemed to correspond to the differentiated NSCs. The results presented here give useful information for the future design of biomaterials to regulate the preservation

  4. Novel Emergency Medicine Curriculum Utilizing Self-Directed Learning and the Flipped Classroom Method: Genitourinary Emergencies Small Group Module

    Directory of Open Access Journals (Sweden)

    Andrew King

    2017-07-01

    Full Text Available Audience: This curriculum, created and implemented at The Ohio State University Wexner Medical Center, was designed to educate our emergency medicine (EM residents, PGY-1 to PGY-3, as well as medical students. Introduction: In 2013, there were over 6 million Emergency Department visits in the United States which resulted in a primary diagnosis of the genitourinary system. This represents 5.2% of all Emergency Department visits.1 Residents must be proficient in the differential diagnosis and management of the wide variety of genitourinary emergencies. This flipped classroom curricular model emphasizes self-directed learning activities completed by learners, followed by small group discussions pertaining to the topic reviewed. The active learning fostered by this curriculum increases faculty and learner engagement and interaction time typically absent in traditional lecture-based formats.2-4 Studies have revealed that the application of knowledge through case studies, personal interaction with content experts, and integrated questions are effective learning strategies for emergency medicine residents.4-6 The Ohio State University Wexner Medical Center EM Residency didactic curriculum recently transitioned to a “flipped classroom” approach.7-10 We created this innovative curriculum aimed to improve our residency education program and to share educational resources with other EM residency programs. Our curriculum utilizes an 18-month curricular cycle to cover the defined emergency medicine content. The flipped classroom curriculum maximizes didactic time and resident engagement, fosters intellectual curiosity and active learning, and meets the needs of today’s learners. 3,6,11 Objectives: We aim to teach the presentation and management of genitourinary emergencies through the creation of a flipped classroom design. This unique, innovative curriculum utilizes resources chosen by education faculty and resident learners, study questions, real

  5. Novel Emergency Medicine Curriculum Utilizing Self-Directed Learning and the Flipped Classroom Method: Gastrointestinal Emergencies Small Group Module

    Directory of Open Access Journals (Sweden)

    Andrew King

    2017-01-01

    Full Text Available Audience and type of curriculum: This curriculum created and implemented at The Ohio State University Wexner Medical Center was designed to educate our emergency medicine (EM residents, PGY-1 to PGY-3, as well as medical students and attending physicians. Introduction/Background: Gastrointestinal (GI emergencies comprise approximately 12% of emergency department (ED visits.1 Residents must be proficient in the differential diagnosis and management of the wide variety of GI emergencies. The flipped classroom curricular model emphasizes self-directed learning activities completed by learners, followed by small group discussions pertaining to the topic reviewed. The active learning fostered by this curriculum increases faculty and learner engagement and interaction time typically absent in traditional lecture-based formats.2-4 Studies have revealed that the application of knowledge through case studies, personal interaction with content experts, and integrated questions are effective learning strategies for emergency medicine residents.4-6 The Ohio State University EM Residency didactic curriculum recently transitioned to a “flipped classroom” approach.7-10 We created this innovative curriculum aimed to improve our residency education program and to share educational resources with other EM residency programs. This proposed curriculum utilizes an 18-month curricular cycle. The flipped classroom curriculum maximizes didactic time and resident engagement, fosters intellectual curiosity and active learning, and meets the needs of today’s learners. 3,6,11 Objectives: We aim to teach the presentation and management of GI emergencies through the creation of a flipped classroom design. This unique, innovative curriculum utilizes resources chosen by education faculty and resident learners, study questions, real-life experiences, and small group discussions in place of traditional lectures. In doing so, a goal of the curriculum is to encourage self-directed

  6. Novel Emergency Medicine Curriculum Utilizing Self-Directed Learning and the Flipped Classroom Method: Psychiatric Emergencies Small Group Module

    Directory of Open Access Journals (Sweden)

    Andrew King

    2017-07-01

    Full Text Available Audience: This curriculum created and implemented at The Ohio State University Wexner Medical Center was designed to educate our emergency medicine (EM residents, PGY-1 to PGY-3, as well as medical students and attending physicians. Introduction: In 2007, there were 12 million adult Emergency Department visits for mental health and substance abuse complaints. This represents 12.5% of all adult emergency department visits.1 Residents must be proficient in the differential diagnosis and management of the wide variety of psychiatric emergencies. The flipped classroom curricular model emphasizes self-directed learning activities completed by learners, followed by small group discussions pertaining to the topic reviewed. The active learning fostered by this curriculum increases faculty and learner engagement and interaction time typically absent in traditional lecture-based formats.2-4 Studies have revealed that the application of knowledge through case studies, personal interaction with content experts, and integrated questions are effective learning strategies for emergency medicine residents.4-6 The Ohio State University EM Residency didactic curriculum recently transitioned to a “flipped classroom” approach.7-10 We created this innovative curriculum aimed to improve our residency education program and to share educational resources with other EM residency programs. Our curriculum utilizes an 18-month curricular cycle to cover the defined emergency medicine content. The flipped classroom curriculum maximizes didactic time and resident engagement, fosters intellectual curiosity and active learning, and meets the needs of today’s learners. 3,6,11 Objectives: We aim to teach the presentation and management of psychiatric emergencies through the creation of a flipped classroom design. This unique, innovative curriculum utilizes resources chosen by education faculty and resident learners, study questions, real-life experiences, and small group

  7. ALMA Observations of Molecular Clouds in Three Group-centered Elliptical Galaxies: NGC 5846, NGC 4636, and NGC 5044

    Science.gov (United States)

    Temi, Pasquale; Amblard, Alexandre; Gitti, Myriam; Brighenti, Fabrizio; Gaspari, Massimo; Mathews, William G.; David, Laurence

    2018-05-01

    We present new ALMA CO(2–1) observations of two well-studied group-centered elliptical galaxies: NGC 4636 and NGC 5846. In addition, we include a revised analysis of Cycle 0 ALMA observations of the central galaxy in the NGC 5044 group. We find evidence that molecular gas is a common presence in bright group-centered galaxies (BGG). CO line widths are broader than Galactic molecular clouds, and using the reference Milky Way X CO, the total molecular mass ranges from 2.6 × 105 M ⊙ in NGC 4636 to 6.1 × 107 M ⊙ in NGC 5044. Complementary observations using the ALMA Compact Array do not exhibit any detection of a CO diffuse component at the sensitivity level achieved by current exposures. The origin of the detected molecular features is still uncertain, but these ALMA observations suggest that they are the end product of the hot gas cooling process and not the result of merger events. Some of the molecular clouds are associated with dust features as revealed by HST dust extinction maps, suggesting that these clouds formed from dust-enhanced cooling. The global nonlinear condensation may be triggered via the chaotic turbulent field or buoyant uplift. The large virial parameter of the molecular structures and correlation with the warm ({10}3{--}{10}5 {{K}})/hot (≥106) phase velocity dispersion provide evidence that they are unbound giant molecular associations drifting in the turbulent field, consistent with numerical predictions of the chaotic cold accretion process. Alternatively, the observed large CO line widths may be generated by molecular gas flowing out from cloud surfaces due to heating by the local hot gas atmosphere.

  8. Tag team simulation: An innovative approach for promoting active engagement of participants and observers during group simulations.

    Science.gov (United States)

    Levett-Jones, Tracy; Andersen, Patrea; Reid-Searl, Kerry; Guinea, Stephen; McAllister, Margaret; Lapkin, Samuel; Palmer, Lorinda; Niddrie, Marian

    2015-09-01

    Active participation in immersive simulation experiences can result in technical and non-technical skill enhancement. However, when simulations are conducted in large groups, maintaining the interest of observers so that they do not disengage from the learning experience can be challenging. We implemented Tag Team Simulation with the aim of ensuring that both participants and observers had active and integral roles in the simulation. In this paper we outline the features of this innovative approach and provide an example of its application to a pain simulation. Evaluation was conducted using the Satisfaction with Simulation Experience Scale. A total of 444 year nursing students participated from a population of 536 (response rate 83%). Cronbach's alpha for the Scale was .94 indicating high internal consistency. The mean satisfaction score for participants was 4.63 compared to 4.56 for observers. An independent sample t test revealed no significant difference between these scores (t (300) = -1.414, p = 0.16). Tag team simulation is an effective approach for ensuring observers' and participants' active involvement during group-based simulations and one that is highly regarded by students. It has the potential for broad applicability across a range of leaning domains both within and beyond nursing. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Quantifying the weight of fingerprint evidence through the spatial relationship, directions and types of minutiae observed on fingermarks.

    Science.gov (United States)

    Neumann, Cedric; Champod, Christophe; Yoo, Mina; Genessay, Thibault; Langenburg, Glenn

    2015-03-01

    This paper presents a statistical model for the quantification of the weight of fingerprint evidence. Contrarily to previous models (generative and score-based models), our model proposes to estimate the probability distributions of spatial relationships, directions and types of minutiae observed on fingerprints for any given fingermark. Our model is relying on an AFIS algorithm provided by 3M Cogent and on a dataset of more than 4,000,000 fingerprints to represent a sample from a relevant population of potential sources. The performance of our model was tested using several hundreds of minutiae configurations observed on a set of 565 fingermarks. In particular, the effects of various sub-populations of fingers (i.e., finger number, finger general pattern) on the expected evidential value of our test configurations were investigated. The performance of our model indicates that the spatial relationship between minutiae carries more evidential weight than their type or direction. Our results also indicate that the AFIS component of our model directly enables us to assign weight to fingerprint evidence without the need for the additional layer of complex statistical modeling involved by the estimation of the probability distributions of fingerprint features. In fact, it seems that the AFIS component is more sensitive to the sub-population effects than the other components of the model. Overall, the data generated during this research project contributes to support the idea that fingerprint evidence is a valuable forensic tool for the identification of individuals. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Directional topographic site response at Tarzana observed in aftershocks of the 1994 Northridge, California, earthquake: Implications for mainshock motions

    Science.gov (United States)

    Spudich, P.; Hellweg, M.; Lee, W.H.K.

    1996-01-01

    The Northridge earthquake caused 1.78 g acceleration in the east-west direction at a site in Tarzana, California, located about 6 km south of the mainshock epicenter. The accelerograph was located atop a hill about 15-m high, 500-m long, and 130-m wide, striking about N78??E. During the aftershock sequence, a temporary array of 21 three-component geophones was deployed in six radial lines centered on the accelerograph, with an average sensor spacing of 35 m. Station COO was located about 2 m from the accelerograph. We inverted aftershock spectra to obtain average relative site response at each station as a function of direction of ground motion. We identified a 3.2-Hz resonance that is a transverse oscillation of the hill (a directional topographic effect). The top/base amplification ratio at 3.2 Hz is about 4.5 for horizontal ground motions oriented approximately perpendicular to the long axis of the hill and about 2 for motions parallel to the hill. This resonance is seen most strongly within 50 m of COO. Other resonant frequencies were also observed. A strong lateral variation in attenuation, probably associated with a fault, caused substantially lower motion at frequencies above 6 Hz at the east end of the hill. There may be some additional scattered waves associated with the fault zone and seen at both the base and top of the hill, causing particle motions (not spectral ratios) at the top of the hill to be rotated about 20?? away from the direction transverse to the hill. The resonant frequency, but not the amplitude, of our observed topographic resonance agrees well with theory, even for such a low hill. Comparisons of our observations with theoretical results indicate that the 3D shape of the hill and its internal structure are important factors affecting its response. The strong transverse resonance of the hill does not account for the large east-west mainshock motions. Assuming linear soil response, mainshock east-west motions at the Tarzana accelerograph

  11. Direct Observation of a Nonheme Iron(IV)–Oxo Complex That Mediates Aromatic C–F Hydroxylation

    OpenAIRE

    Sahu, Sumit; Quesne, Matthew G.; Davies, Casey G.; Dürr, Maximilian; Ivanović-Burmazović, Ivana; Siegler, Maxime A.; Jameson, Guy N. L.; de Visser, Sam P.; Goldberg, David P.

    2014-01-01

    The synthesis of a pentadentate ligand with strategically designed fluorinated arene groups in the second coordination sphere of a nonheme iron center is reported. The oxidatively resistant fluorine substituents allow for the trapping and characterization of an FeIV(O) complex at −20 °C. Upon warming of the FeIV(O) complex, an unprecedented arene C–F hydroxylation reaction occurs. Computational studies support the finding that substrate orientation is a critical factor in the observed reactiv...

  12. Implementation of directly observed patient hand hygiene for hospitalized patients by hand hygiene ambassadors in Hong Kong.

    Science.gov (United States)

    Cheng, Vincent C C; Tai, Josepha W M; Li, W S; Chau, P H; So, Simon Y C; Wong, Lisa M W; Ching, Radley H C; Ng, Modissa M L; Ho, Sara K Y; Lee, Doris W Y; Lee, W M; Wong, Sally C Y; Yuen, K Y

    2016-06-01

    The importance of compliance with hand hygiene by patients is increasingly recognized to prevent health care-associated infections. This descriptive study observed the effects of an education campaign, targeted to increase patients' self-initiated hand hygiene, and a hand hygiene ambassador-initiated directly observed hand hygiene program on patients' hand hygiene compliance in a university-affiliated hospital. The overall audited compliance of patients' self-initiated hand hygiene was only 37.5%, with a rate of 26.9% (112/416 episodes) before meals and medications, 27.5% (19/69 episodes) after using a urinal or bedpan, and 89.7% (87/97 episodes) after attending toilet facilities. Patients referred from a residential care home for older adults had significantly lower hand hygiene compliance (P = .007). Comparatively, the overall audited compliance of ambassador-initiated directly observed hand hygiene was 97.3% (428/440 episodes), which was significantly higher than patients' self-initiated hand hygiene via a patient education program (37.5%, 218/582 episodes, P hand hygiene can play an important role in improving compliance with hand hygiene by hospitalized patients. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  13. Derivation of the Boltzmann Equation for Financial Brownian Motion: Direct Observation of the Collective Motion of High-Frequency Traders

    Science.gov (United States)

    Kanazawa, Kiyoshi; Sueshige, Takumi; Takayasu, Hideki; Takayasu, Misako

    2018-03-01

    A microscopic model is established for financial Brownian motion from the direct observation of the dynamics of high-frequency traders (HFTs) in a foreign exchange market. Furthermore, a theoretical framework parallel to molecular kinetic theory is developed for the systematic description of the financial market from microscopic dynamics of HFTs. We report first on a microscopic empirical law of traders' trend-following behavior by tracking the trajectories of all individuals, which quantifies the collective motion of HFTs but has not been captured in conventional order-book models. We next introduce the corresponding microscopic model of HFTs and present its theoretical solution paralleling molecular kinetic theory: Boltzmann-like and Langevin-like equations are derived from the microscopic dynamics via the Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy. Our model is the first microscopic model that has been directly validated through data analysis of the microscopic dynamics, exhibiting quantitative agreements with mesoscopic and macroscopic empirical results.

  14. Direct Observation of Very Large Zero-Field Splitting in a Tetrahedral Ni(II)Se4 Coordination Complex.

    Science.gov (United States)

    Jiang, Shang-Da; Maganas, Dimitrios; Levesanos, Nikolaos; Ferentinos, Eleftherios; Haas, Sabrina; Thirunavukkuarasu, Komalavalli; Krzystek, J; Dressel, Martin; Bogani, Lapo; Neese, Frank; Kyritsis, Panayotis

    2015-10-14

    The high-spin (S = 1) tetrahedral Ni(II) complex [Ni{(i)Pr2P(Se)NP(Se)(i)Pr2}2] was investigated by magnetometry, spectroscopic, and quantum chemical methods. Angle-resolved magnetometry studies revealed the orientation of the magnetization principal axes. The very large zero-field splitting (zfs), D = 45.40(2) cm(-1), E = 1.91(2) cm(-1), of the complex was accurately determined by far-infrared magnetic spectroscopy, directly observing transitions between the spin sublevels of the triplet ground state. These are the largest zfs values ever determined--directly--for a high-spin Ni(II) complex. Ab initio calculations further probed the electronic structure of the system, elucidating the factors controlling the sign and magnitude of D. The latter is dominated by spin-orbit coupling contributions of the Ni ions, whereas the corresponding effects of the Se atoms are remarkably smaller.

  15. Direct observation of mass oscillations due to ablative Richtmyer-Meshkov instability and feedout in planar plastic targets

    International Nuclear Information System (INIS)

    Aglitskiy, Y.; Velikovich, A.L.; Karasik, M.; Serlin, V.; Pawley, C.J.; Schmitt, A.J.; Obenschain, S.P.; Mostovych, A.N.; Gardner, J.H.; Metzler, N.

    2002-01-01

    Perturbations that seed Rayleigh-Taylor (RT) instability in laser-driven targets form during the early-time period. This time includes a shock wave transit from the front to the rear surface of the target, and a rarefaction wave transit in the opposite direction. During this time interval, areal mass perturbations caused by all sources of nonuniformity (laser imprint, surface ripple) are expected to oscillate. The first direct experimental observations of the areal mass oscillations due to ablative Richtmyer-Meshkov (RM) instability and feedout followed by the RT growth of areal mass modulation are discussed. The experiments were made with 40-99 μm thick planar plastic targets rippled either on the front or on the rear with a sine wave ripple with either 30 or 45 μm wavelength and with 0.5, 1, or 1.5 μm amplitude. Targets were irradiated with 4 ns long Nike KrF laser pulses at ∼50 TW/cm2. The oscillations were observed with our novel diagnostic technique, a monochromatic x-ray imager coupled to a streak camera. For the ablative RM instability (front side ripple), the mass modulation amplitude was typically observed to grow, reach a peak, and then decrease, after which the exponential RT growth started. In some cases, one phase reversal due to the ablative RM instability was observed. For the feedout geometry (rear side ripple), in all cases two phase reversals were observed: a distinct half-oscillation was followed by the onset of the RT growth, resulting in a second phase reversal

  16. Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group

    International Nuclear Information System (INIS)

    Sjoestroem, A.; Carlsson, J.; Lundqvist, H.; Koziorowski, J.

    2003-01-01

    A method for direct astatine labeling of proteins has been investigated. Binding sites for astatine were created by coupling of a nido-carborane derivative to a protein, the human epidermal growth factor (hEGF), using two different conjugation methods - by glutaraldehyde cross-linking or by introduction of sulfohydryl groups by Traut's reagent with subsequent linking of ANC-1 with m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester. The conjugates were astatinated using the Chloramine-T method in high yield. The best labeling was obtained by the glutaraldehyde conjugate with an average yield of 68 ± 9%. In vitro stability tests indicated that the glutaraldehyde conjugated label was as stable as hEGF labeled with astatobenzoate. (author)

  17. Researching the value system of interest groups as the starting point for directing urbanisation of the countryside

    Directory of Open Access Journals (Sweden)

    Mojca Golobič

    2001-01-01

    Full Text Available When planning rehabilitation of transitory, rural space, where processes of restructuring agriculture intertwine with urban processes, key definitions concern places where restructuring agriculture and changes in land use are causing degradation and places where further urbanisation or re-naturation are the better option. In these definitions it is necessary to follow opinions and goals of users that are nevertheless difficult to obtain in a mode that can be directly integrated in standardised rational procedures of physical planning. The presented procedure facilitates the procurement of such knowledge and its transparent integration in local development plans. Thus we can identify interest groups, their viewpoints, and potential conflicts in initial value systems and check their conflicting or harmonising starting points in space.

  18. Cyberinfrastructure Initiatives of the Committee on Earth Observation Satellites (CEOS) Working Group on Information Systems and Services (WGISS)

    Science.gov (United States)

    McDonald, K. R.; Faundeen, J. L.; Petiteville, I.

    2005-12-01

    The Committee on Earth Observation Satellites (CEOS) was established in 1984 in response to a recommendation from the Economic Summit of Industrialized Nations Working Group on Growth, Technology, and Employment's Panel of Experts on Satellite Remote Sensing. CEOS participants are Members, who are national or international governmental organizations who operate civil spaceborne Earth observation satellites, and Associates who are governmental organizations with civil space programs in development or international scientific or governmental bodies who have an interest in and support CEOS objectives. The primary objective of CEOS is to optimize benefits of satellite Earth observations through cooperation of its participants in mission planning and in development of compatible data products, formats, services, applications and policies. To pursue its objectives, CEOS establishes working groups and associated subgroups that focus on relevant areas of interest. While the structure of CEOS has evolved over its lifetime, today there are three permanent working groups. One is the Working Group on Calibration and Validation that addresses sensor-specific calibration and validation and geophysical parameter validation. A second is the Working Group on Education, Training, and Capacity Building that facilitates activities that enhance international education and training in Earth observation techniques, data analysis, interpretation and applications, with a particular focus on developing countries. The third permanent working group is the Working Group on Information Systems and Services (WGISS). The purpose of WGISS is to promote collaboration in the development of the systems and services based on international standards that manage and supply the Earth observation data and information from participating agencies' missions. WGISS places great emphasis on the use of demonstration projects involving user groups to solve the critical interoperability issues associated with the

  19. Adherence is associated with the quality of professional-patient interaction in Directly Observed Treatment Short-course, DOTS

    DEFF Research Database (Denmark)

    Mishra, Pranaya; Hansen, Ebba Holme; Sabroe, Svend

    2006-01-01

    OBJECTIVE: To investigate the association between the behaviour of health professionals as reported by patients, the quality of communication, patients' communication about their disease, and non-adherence to Directly Observed Tuberculosis Treatment Short-course, DOTS. METHODS: This study...... was designed as a case-control study based on 50 cases (non-adherents) and 100 controls (adherents), conducted in a hilly western district in Nepal. The participation rate was 80% for 50 cases and 95% for 100 controls. All covariates with p-value

  20. Direct observation of shear–induced nanocrystal attachment and coalescence in CuZr-based metallic glasses: TEM investigation

    International Nuclear Information System (INIS)

    Hajlaoui, K.; Alrasheedi, Nashmi H.; Yavari, A.R.

    2016-01-01

    In-situ tensile straining tests were performed in a transmission electron microscope (TEM) to analyse the deformation processes in CuZr-based metallic glasses and to directly observe the phase transformation occurrence. We report evidence of shear induced coalescence of nanocrystals in the vicinity of deformed regions. Nanocrystals grow in shear bands, come into contact, being attached and progressively coalesce under applied shear stress. - Highlights: • In-situ tensile straining test in TEM was investigated on CuZr-Based metallic glass. • Strain induces nanocrystallization and subsequent attachment and coalescence of nanocrystals. • The coalescence of nanocrystals compensates strain softening in metallic glasses.

  1. Views of parents, teachers and children on health promotion in kindergarten--first results from formative focus groups and observations.

    Science.gov (United States)

    Sansolios, Sanne; Mikkelsen, Bent Egberg

    2011-10-01

    The aim of the study was to capture the views of children, parents and teachers on the topic of physical activity in kindergarten through observation and focus group interviews. The study was conducted in the kindergartens from the sampling group in the Danish part of PERISCOPE. 1(st) methodology: Children interviewed inside by the researcher on preferable movements and settings and then observed outside during their playtime. 2(nd) methodology: Children asked to draw themselves playing their most preferred physical activity. Parents and kindergarten teachers interviewed in two different groups, using an identical guide. Children are skilled in taking advantage of the space and facilities available for physical activity; girls need more support than boys to initiate physical activity; children are happy with the facilities and the toys available in the kindergarten. Teachers feel an increasing pressure to take more responsibility and initiatives for the children's health habits. Parents state that if more physical activity is initiated in the kindergarten, it could make children request domestic activity. Physical activity and movement concept are too abstract for children of this age to talk about: they quickly lose their focus and concentration. The new methodology of videotaping gives the researcher the chance to interpret facial expressions to capture movement, talk and actions, and to make a distinction among children, as they tend to interrupt each other. However, this method contains a weakness, if used alone, by the fact that the shooting is only a reflection of what the video camera has recorded.

  2. Direct nitrate reductase assay versus microscopic observation drug susceptibility test for rapid detection of MDR-TB in Uganda.

    Directory of Open Access Journals (Sweden)

    Freddie Bwanga

    Full Text Available The most common method for detection of drug resistant (DR TB in resource-limited settings (RLSs is indirect susceptibility testing on Lowenstein-Jensen medium (LJ which is very time consuming with results available only after 2-3 months. Effective therapy of DR TB is therefore markedly delayed and patients can transmit resistant strains. Rapid and accurate tests suitable for RLSs in the diagnosis of DR TB are thus highly needed. In this study we compared two direct techniques--Nitrate Reductase Assay (NRA and Microscopic Observation Drug Susceptibility (MODS for rapid detection of MDR-TB in a high burden RLS. The sensitivity, specificity, and proportion of interpretable results were studied. Smear positive sputum was collected from 245 consecutive re-treatment TB patients attending a TB clinic in Kampala, Uganda. Samples were processed at the national reference laboratory and tested for susceptibility to rifampicin and isoniazid with direct NRA, direct MODS and the indirect LJ proportion method as reference. A total of 229 specimens were confirmed as M. tuberculosis, of these interpretable results were obtained in 217 (95% with either the NRA or MODS. Sensitivity, specificity and kappa agreement for MDR-TB diagnosis was 97%, 98% and 0.93 with the NRA; and 87%, 95% and 0.78 with the MODS, respectively. The median time to results was 10, 7 and 64 days with NRA, MODS and the reference technique, respectively. The cost of laboratory supplies per sample was low, around 5 USD, for the rapid tests. The direct NRA and MODS offered rapid detection of resistance almost eight weeks earlier than with the reference method. In the study settings, the direct NRA was highly sensitive and specific. We consider it to have a strong potential for timely detection of MDR-TB in RLS.

  3. Resistance to changing practice from pro re nata prescriptions to patient group directions in acute mental health settings.

    Science.gov (United States)

    Price, O; Baker, J A

    2013-09-01

    Poor practice associated with pro re nata (PRN) prescriptions in mental health is known to be common and can increase the risk of serious and potentially fatal side effects. A contributing factor to poor practice is the lack of a clear chain of accountability between the decision to prescribe and administer PRN prescriptions. To address this problem, a patient group direction (PGD) for acute behavioural disturbance (lorazepam 0.5-2 mg) and staff training materials were developed. The intention was to replace PRN prescriptions with the PGD in two mental health trusts. One of the potential benefits of this would be the removal of the contribution of PRN to high and combined dose antipsychotic prescriptions. This proposal, however, was met with significant resistance in both trusts and did not replace PRN as a result. A series of interviews and focus groups were conducted with 16 RMNs working in the two trusts, to explore the reasons why the PGD was met with resistance. Senior nurses perceived resistance to be associated with anxieties over increased responsibility for decision making. Junior nurses reported concerns regarding the medicalization of the nursing role, the paperwork associated with the PGD and the training approach used. Future efforts to implement PGDs in mental health settings must carefully consider the methods for engaging effectively with participating organizations, in terms of managing change and completing the necessary groundwork for successful implementation. © 2012 John Wiley & Sons Ltd.

  4. Direct observation of superconducting gaps in MgB{sub 2} by angle-resolved photoemission spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Souma, S.; Machida, Y.; Sato, T.; Takahashi, T.; Matsui, H.; Wang, S.-C.; Ding, H.; Kaminski, A.; Campuzano, J.C.; Sasaki, S.; Kadowaki, K

    2004-08-01

    High-resolution angle-resolved photoemission spectroscopy has been carried out to clarify the anomalous superconductivity of MgB{sub 2}. We observed three bands crossing the Fermi level, which are ascribed to B2p-{sigma}, {pi} and surface bands. We have succeeded for the first time in directly observing the superconducting gaps of these bands separately. We have found that the superconducting-gap sizes of {sigma} and surface bands are 6.5 {+-} 0.5 and 6.0 {+-} 0.5 meV, respectively, while that of the {pi} band is much smaller (1.5 {+-} 0.5 meV). The present experimental result unambiguously demonstrates the validity of the two-band superconductivity in MgB{sub 2}.

  5. Direct Observation of the M1 Transition between the Ground Term Fine Structure Levels of W VIII

    Directory of Open Access Journals (Sweden)

    Momoe Mita

    2017-03-01

    Full Text Available We present a direct observation of the M1 transition between the fine structure splitting in the 4 f 13 5 s 2 5 p 6 2 F ground term of W VIII. The spectroscopic data of few-times ionized tungsten ions are important for the future ITER diagnostics, but there is a serious lack of data. The present study is part of an ongoing effort to solve this problem. Emission from the tungsten ions produced and trapped in a compact electron beam ion trap is observed with a Czerny–Turner visible spectrometer. Spectra in the EUV range are also observed at the same time to help identify the previously-unreported visible lines. The observed wavelength 574.47 ± 0.03 nm (air, which corresponds to the fine structure splitting of 17,402.5 ± 0.9 cm − 1 , shows reasonable agreement with the previously reported value 17,410 ± 5 cm − 1 obtained indirectly through the analysis of EUV spectra [Ryabtsev et al., Atoms 3 (2015 273].

  6. Mesoscopic simulation of dendritic growth observed in x-ray video microscopy during directional solidification of Al-Cu alloys

    International Nuclear Information System (INIS)

    Delaleau, Pierre; Beckermann, Christoph; Mathiesen, Ragnvald H.; Arnberg, Lars

    2010-01-01

    A mesoscopic model is developed to simulate microstructures observed in situ by X-ray video microscopy during directional solidification of Al-Cu alloys in a Hele-Shaw cell. In the model, a volume-averaged species conservation equation is solved to obtain the solute concentration and solid fraction fields, and an analytical stagnant film model is used to predict the motion of the dendrite envelopes. The model is carefully validated in several test cases. Then, the model is applied to simulate the columnar dendritic microstructures observed in the X-ray video microscopy experiments for two different alloy compositions. Reasonable agreement is found between the measured and predicted dendrite envelope shapes, solid fractions, and solute concentration fields. The predicted size of the mushy zone and the extent of the undercooled melt region ahead of the columnar front agree well with the in situ experimental observations. The simulation results show quantitative agreement with the internal solid fraction variations measured from the radiographs. The present model is also able to realistically simulate a primary dendrite trunk spacing adjustment that was observed in one of the experiments. Overall, the present study represents the first successful validation of a solidification model using real time, in situ data from an experiment with a metallic alloy. Considerable additional research is needed to account in the model for the effect of gravity driven melt convection. (author)

  7. Optical Observations of M81 Galaxy Group in Narrow Band [SII] and H_alpha Filters: Holmberg IX

    Directory of Open Access Journals (Sweden)

    Arbutina, B.

    2009-12-01

    Full Text Available We present observations of the nearby tidal dwarf galaxy Holmberg IX in M81 galaxy group in narrow band [SII] and H$alpha$ filters, carried out in March and November 2008 with the 2m RCC telescope at NAO Rozhen, Bulgaria. Our search for resident supernova remnants (identified as sources with enhanced [SII] emission relative to their H$alpha$ emission in this galaxy yielded no sources of this kind, besides M&H 10-11 or HoIX X-1. Nevertheless, we found a number of objects with significant H$alpha$ emission that probably represent uncatalogued HII regions.

  8. THE EMPIRICAL METHOD OF INVESTIGATING THE CHILDHOOD SUBCULTURE: GROUP OF CHILDREN BEHAVIOR OBSERVATION IN THE GUESTHOUSE POOL

    Directory of Open Access Journals (Sweden)

    Ms. Yelena N. Suvorkina

    2016-12-01

    Full Text Available The article deals with one of the empirical research methods investigating the childhood sub-culture. The method is called observation. The author marked general theoretical position, recommendations on its implementation. Based on observations of the group of children behavior in the guesthouse pool it is found out that such category, as honesty is very important in the organization of the order, taking into account that the subculture of childhood is an open, self-organizing system. In the pool, the children come up with a wide variety of games. The adjacent areas are also involved. The author identified two borders, taking place for the child: a clear (fixed border is the side of the pool and unclear border as the transitional designation of states, qualities (dangerous – safe.

  9. A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution.

    Science.gov (United States)

    Hasegawa, Sumitaka; Maruyama, Kouichi; Takenaka, Hikaru; Furukawa, Takako; Saga, Tsuneo

    2009-08-18

    The recent success with small fish as an animal model of cancer with the aid of fluorescence technique has attracted cancer modelers' attention because it would be possible to directly visualize tumor cells in vivo in real time. Here, we report a medaka model capable of allowing the observation of various cell behaviors of transplanted tumor cells, such as cell proliferation and metastasis, which were visualized easily in vivo. We established medaka melanoma (MM) cells stably expressing GFP and transplanted them into nonirradiated and irradiated medaka. The tumor cells were grown at the injection sites in medaka, and the spatiotemporal changes were visualized under a fluorescence stereoscopic microscope at a cellular-level resolution, and even at a single-cell level. Tumor dormancy and metastasis were also observed. Interestingly, in irradiated medaka, accelerated tumor growth and metastasis of the transplanted tumor cells were directly visualized. Our medaka model provides an opportunity to visualize in vivo tumor cells "as seen in a culture dish" and would be useful for in vivo tumor cell biology.

  10. Direct observation of radial distribution change during tensile deformation of metallic glass by high energy X-ray diffraction method

    Energy Technology Data Exchange (ETDEWEB)

    Nasu, Toshio, E-mail: nasu@kekexafs.kj.yamagata-u.ac.j [Faculty of Education, Arts and Science, Yamagata University, 1-4-12 Kojirakawa, Yamagata, Yamagata, 990-8560 (Japan); Sasaki, Motokatsu [Faculty of Education, Arts and Science, Yamagata University, 1-4-12 Kojirakawa, Yamagata, Yamagata, 990-8560 (Japan); Usuki, Takeshi; Sekine, Mai [Faculty of Science, Yamagata University, Yamagata 990-8560 (Japan); Takigawa, Yorinobu; Higashi, Kenji [Graduate School of Engineering, Osaka Prefecture University, Sakai 599-8531 (Japan); Kohara, Shinji [Japan Synchrotron Radiation Research Institute, Harima Science Garden City, Sayo town, Hyogo 679-5198 (Japan); Sakurai, Masaki; Wei Zhang; Inoue, Akihisa [Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan)

    2009-08-26

    The purpose of this research is to investigate the micro-mechanism of deformation behavior of metallic glasses. We report the results of direct observations of short-range and medium-range structural change during tensile deformation of metallic glasses by high energy X-ray diffraction method. Cu{sub 50}Zr{sub 50} and Ni{sub 30}Zr{sub 70} metallic glass samples in the ribbon shape (1.5 mm width and 25 mum) were made by using rapid quenching method. Tensile deformation added to the sample was made by using special equipment adopted for measuring the high energy X-ray diffraction. The peaks in pair distribution function g(r) for Cu{sub 50}Zr{sub 50} and N{sub 30}iZr{sub 70} metallic glasses move zigzag into front and into rear during tensile deformation. These results of direct observation on atomic distribution change for Cu{sub 50}Zr{sub 50} and Ni{sub 30}Zr{sub 70} metallic glass ribbons during tensile deformation suggest that the micro-relaxations occur.

  11. Evaluating the Effects of Differences in Group Abilities on the Tucker and the Levine Observed-Score Methods for Common-Item Nonequivalent Groups Equating. ACT Research Report Series 2010-1

    Science.gov (United States)

    Chen, Hanwei; Cui, Zhongmin; Zhu, Rongchun; Gao, Xiaohong

    2010-01-01

    The most critical feature of a common-item nonequivalent groups equating design is that the average score difference between the new and old groups can be accurately decomposed into a group ability difference and a form difficulty difference. Two widely used observed-score linear equating methods, the Tucker and the Levine observed-score methods,…

  12. Removal of trichloroethylene DNAPL trapped in porous media using nanoscale zerovalent iron and bimetallic nanoparticles: Direct observation and quantification

    International Nuclear Information System (INIS)

    Wang, Qiliang; Jeong, Seung-Woo; Choi, Heechul

    2012-01-01

    Highlights: ► TCE DNAPL removal inside pores using NZVI or bimetals in a 2-D system was visualized. ► Presence of nitrate and humic substances decrease the TCE DNAPL removal efficiency. ► Presence of ethanol increases the TCE DNAPL removal efficiency. ► Metal catalysts enhance the TCE DNAPL removal using NZVI in a short term reaction. ► Metal catalysts do not increase the DNAPL removal efficiency for a long term reaction. - Abstract: Direct trichloroethylene (TCE) dense non-aqueous phase liquid (DNAPL) removal inside pore areas using nanoscale zerovalent iron (NZVI) and bimetallic nanoparticles were first investigated in a water-saturated porous glass micromodel. Effects of nitrate, aqueous ethanol co-solvent, humic substance, and elapsed time on TCE DNAPL removal using NZVI were studied by direct visualization. The removal efficiency was then quantified by directly measuring the remaining TCE DNAPL blobs area using an image analyzer. As ethanol content of co-solvent increased, TCE DNAPL removal by NZVI was also increased implying sequential TCE DNAPL removal mechanisms: as dissolved TCE was degraded by NZVI, TCE dissolution from TCE blobs would be then facilitated and the TCE blob areas would be eventually reduced. The presence of nitrate and humic substance hindered the NZVI reactivity for the TCE DNAPL removal. In contrast, the TCE DNAPL removal efficiency was enhanced using bimetallic nanoparticles in a short-term reaction by generating atomic hydrogen for catalytic hydro-dechlorination. However, all TCE DNAPL removal efficiencies reached the same level after long-term reaction using both NZVI and bimetallic nanoparticles. Direct TCE DNAPL observation clearly implied that TCE blobs existed for long time even though all TCE blobs were fully exposed to NZVI and bimetallic nanoparticles.

  13. Removal of trichloroethylene DNAPL trapped in porous media using nanoscale zerovalent iron and bimetallic nanoparticles: Direct observation and quantification

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Qiliang [School of Environmental Science and Engineering, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro, Buk-gu, 500-712 Gwangju (Korea, Republic of); Jeong, Seung-Woo, E-mail: swjeong@kunsan.ac.kr [Department of Environmental Engineering, Kunsan National University, Kunsan 550-701 (Korea, Republic of); Choi, Heechul, E-mail: hcchoi@gist.ac.kr [School of Environmental Science and Engineering, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro, Buk-gu, 500-712 Gwangju (Korea, Republic of)

    2012-04-30

    Highlights: Black-Right-Pointing-Pointer TCE DNAPL removal inside pores using NZVI or bimetals in a 2-D system was visualized. Black-Right-Pointing-Pointer Presence of nitrate and humic substances decrease the TCE DNAPL removal efficiency. Black-Right-Pointing-Pointer Presence of ethanol increases the TCE DNAPL removal efficiency. Black-Right-Pointing-Pointer Metal catalysts enhance the TCE DNAPL removal using NZVI in a short term reaction. Black-Right-Pointing-Pointer Metal catalysts do not increase the DNAPL removal efficiency for a long term reaction. - Abstract: Direct trichloroethylene (TCE) dense non-aqueous phase liquid (DNAPL) removal inside pore areas using nanoscale zerovalent iron (NZVI) and bimetallic nanoparticles were first investigated in a water-saturated porous glass micromodel. Effects of nitrate, aqueous ethanol co-solvent, humic substance, and elapsed time on TCE DNAPL removal using NZVI were studied by direct visualization. The removal efficiency was then quantified by directly measuring the remaining TCE DNAPL blobs area using an image analyzer. As ethanol content of co-solvent increased, TCE DNAPL removal by NZVI was also increased implying sequential TCE DNAPL removal mechanisms: as dissolved TCE was degraded by NZVI, TCE dissolution from TCE blobs would be then facilitated and the TCE blob areas would be eventually reduced. The presence of nitrate and humic substance hindered the NZVI reactivity for the TCE DNAPL removal. In contrast, the TCE DNAPL removal efficiency was enhanced using bimetallic nanoparticles in a short-term reaction by generating atomic hydrogen for catalytic hydro-dechlorination. However, all TCE DNAPL removal efficiencies reached the same level after long-term reaction using both NZVI and bimetallic nanoparticles. Direct TCE DNAPL observation clearly implied that TCE blobs existed for long time even though all TCE blobs were fully exposed to NZVI and bimetallic nanoparticles.

  14. Direct observation of electrothermal instability structures on intensely Ohmically heated aluminum with current flowing in a surface skin layer

    Science.gov (United States)

    Awe, Thomas

    2017-10-01

    Implosions on the Z Facility assemble high-energy-density plasmas for radiation effects and ICF experiments, but achievable stagnation pressures and temperatures are degraded by the Magneto-Rayleigh-Taylor (MRT) instability. While the beryllium liners (tubes) used in Magnetized Liner Inertial Fusion (MagLIF) experiments are astonishingly smooth (10 to 50 nm RMS roughness), they also contain distributed micron-scale resistive inclusions, and large MRT amplitudes are observed. Early in the implosion, an electrothermal instability (ETI) may provide a perturbation which greatly exceeds the initial surface roughness of the liner. Resistive inhomogeneities drive nonuniform current density and Joule heating, resulting in locally higher temperature, and thus still higher resistivity. Such unstable temperature and pressure growth produce density perturbations which seed MRT. For MagLIF liners, ETI seeding of MRT has been inferred by evaluating late-time MRT, but a direct observation of ETI is not made. ETI is directly observed on the surface of 1.0-mm-diameter solid Al rods pulsed to 1 MA in 100 ns via high resolution gated optical imaging (2 ns temporal and 3 micron spatial resolution). Aluminum 6061 alloy rods, with micron-scale resistive inclusions, consistently first demonstrate overheating from distinct, 10-micron-scale, sub-eV spots, which 5-10 ns later merge into azimuthally stretched elliptical spots and discrete strata (40-100 microns wide by 10 microns tall). Axial plasma filaments form shortly thereafter. Surface plasma can be suppressed for rods coated with dielectric, enabling extended study of the evolution of stratified ETI structures, and experimental inference of ETI growth rates. This fundamentally new and highly 3-dimensional dataset informs ETI physics, including when the ETI seed of MRT may be initiated.

  15. ERNE observations of energetic particles associated with Earth-directed coronal mass ejections in April and May, 1997

    Directory of Open Access Journals (Sweden)

    A. Anttila

    2000-11-01

    Full Text Available Two Earth-directed coronal mass ejections (CMEs, which were most effective in energetic (~1–50 MeV particle acceleration during the first 18 months since the Solar and Heliospheric Observatory (SOHO launch, occurred on April 7 and May 12, 1997. In the analysis of these events we have deconvoluted the injection spectrum of energetic protons by using the method described by Anttila et al. In order to apply the method developed earlier for data of a rotating satellite (Geostationary Operational Environmental Satellites, GOES, we first had to develop a method to calculate the omnidirectional energetic particle intensities from the observations of Energetic and Relativistic Nuclei and Electrons (ERNE, which is an energetic particle detector onboard the three-axis stabilized SOHO spacecraft. The omnidirectional intensities are calculated by fitting an exponential pitch angle distribution from directional information of energetic protons observed by ERNE. The results of the analysis show that, compared to a much faster and more intensive CMEs observed during the previous solar maximum, the acceleration efficiency decreases fast when the shock propagates outward from the Sun. The particles injected at distances <0.5 AU from the Sun dominate the particle flux during the whole period, when the shock propagates to the site of the spacecraft. The main portion of particles injected by the shock during its propagation further outward from the Sun are trapped around the shock, and are seen as an intensity increase at the time of the shock passage.Key words: Interplanetary physics (interplanetary shocks – Solar physics, astrophysics and astronomy (energetic particles; flares and mass ejections

  16. ERNE observations of energetic particles associated with Earth-directed coronal mass ejections in April and May, 1997

    Directory of Open Access Journals (Sweden)

    A. Anttila

    Full Text Available Two Earth-directed coronal mass ejections (CMEs, which were most effective in energetic (~1–50 MeV particle acceleration during the first 18 months since the Solar and Heliospheric Observatory (SOHO launch, occurred on April 7 and May 12, 1997. In the analysis of these events we have deconvoluted the injection spectrum of energetic protons by using the method described by Anttila et al. In order to apply the method developed earlier for data of a rotating satellite (Geostationary Operational Environmental Satellites, GOES, we first had to develop a method to calculate the omnidirectional energetic particle intensities from the observations of Energetic and Relativistic Nuclei and Electrons (ERNE, which is an energetic particle detector onboard the three-axis stabilized SOHO spacecraft. The omnidirectional intensities are calculated by fitting an exponential pitch angle distribution from directional information of energetic protons observed by ERNE. The results of the analysis show that, compared to a much faster and more intensive CMEs observed during the previous solar maximum, the acceleration efficiency decreases fast when the shock propagates outward from the Sun. The particles injected at distances <0.5 AU from the Sun dominate the particle flux during the whole period, when the shock propagates to the site of the spacecraft. The main portion of particles injected by the shock during its propagation further outward from the Sun are trapped around the shock, and are seen as an intensity increase at the time of the shock passage.

    Key words: Interplanetary physics (interplanetary shocks – Solar physics, astrophysics and astronomy (energetic particles; flares and mass ejections

  17. Je pense donc je fais: transcranial direct current stimulation modulates brain oscillations associated with motor imagery and movement observation

    Directory of Open Access Journals (Sweden)

    Olivia Morgan Lapenta

    2013-06-01

    Full Text Available Motor system neural networks are activated during movement imagery, observation and execution, with a neural signature characterized by suppression of the Mu rhythm. In order to investigate the origin of this neurophysiological marker, we tested whether transcranial direct current stimulation (tDCS modifies Mu rhythm oscillations during tasks involving observation and imagery of biological and non-biological movements. We applied tDCS (anodal, cathodal and sham in 21 male participants (mean age 23.8+3.06, over the left M1 with a current of 2mA for 20 minutes. Following this, we recorded the EEG at C3, C4 and Cz and surrounding C3 and C4 electrodes. Analyses of C3 and C4 showed significant effects for biological vs. non-biological movement (p=0.005, and differential hemisphere effects according to the type of stimulation (p=0.04 and type of movement (p=0.02. Analyses of surrounding electrodes revealed significant interaction effects considering type of stimulation and imagery or observation of biological or non-biological movement (p=0.03. The main findings of this study were (i Mu desynchronization during biological movement of the hand region in the contralateral hemisphere after sham tDCS; (ii polarity-dependent modulation effects of tDCS on the Mu rhythm, i.e. anodal tDCS led to Mu synchronization while cathodal tDCS led to Mu desynchronization during movement observation and imagery (iii specific focal and opposite inter-hemispheric effects, i.e. contrary effects for the surrounding electrodes during imagery condition and also for inter-hemispheric electrodes (C3 vs. C4. These findings provide insights into the cortical oscillations during movement observation and imagery. Furthermore it shows that tDCS can be highly focal when guided by a behavioral task.

  18. Je pense donc je fais: transcranial direct current stimulation modulates brain oscillations associated with motor imagery and movement observation.

    Science.gov (United States)

    Lapenta, Olivia M; Minati, Ludovico; Fregni, Felipe; Boggio, Paulo S

    2013-01-01

    Motor system neural networks are activated during movement imagery, observation and execution, with a neural signature characterized by suppression of the Mu rhythm. In order to investigate the origin of this neurophysiological marker, we tested whether transcranial direct current stimulation (tDCS) modifies Mu rhythm oscillations during tasks involving observation and imagery of biological and non-biological movements. We applied tDCS (anodal, cathodal, and sham) in 21 male participants (mean age 23.8 ± 3.06), over the left M1 with a current of 2 mA for 20 min. Following this, we recorded the EEG at C3, C4, and Cz and surrounding C3 and C4 electrodes. Analyses of C3 and C4 showed significant effects for biological vs. non-biological movement (p = 0.005), and differential hemisphere effects according to the type of stimulation (p = 0.04) and type of movement (p = 0.02). Analyses of surrounding electrodes revealed significant interaction effects considering type of stimulation and imagery or observation of biological or non-biological movement (p = 0.03). The main findings of this study were (1) Mu desynchronization during biological movement of the hand region in the contralateral hemisphere after sham tDCS; (2) polarity-dependent modulation effects of tDCS on the Mu rhythm, i.e., anodal tDCS led to Mu synchronization while cathodal tDCS led to Mu desynchronization during movement observation and imagery (3) specific focal and opposite inter-hemispheric effects, i.e., contrary effects for the surrounding electrodes during imagery condition and also for inter-hemispheric electrodes (C3 vs. C4). These findings provide insights into the cortical oscillations during movement observation and imagery. Furthermore, it shows that tDCS can be highly focal when guided by a behavioral task.

  19. IRIS , Hinode , SDO , and RHESSI Observations of a White Light Flare Produced Directly by Non-thermal Electrons

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyoung-Sun [Hinode Science Center, National Astronomical Observatory of Japan (NAOJ), 2-21-1, Osawa, Mitaka, Tokyo 181-8588 (Japan); Imada, Shinsuke [Institute for Space–Earth Environmental Research (ISEE), Nagoya University, Furo-cho, Chikusa-ku, Nagoya 466-8550 (Japan); Watanabe, Kyoko [National Defense Academy of Japan, 1-10-20 Hashirimizu, Yokosuka 239-8686 (Japan); Bamba, Yumi [Hinode team, ISAS/JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); Brooks, David H., E-mail: ksun.lee@nao.ac.jp [College of Science, George Mason University, 4400 University Drive, Fairfax, VA 22030 (United States)

    2017-02-20

    An X1.6 flare occurred in active region AR 12192 on 2014 October 22 at 14:02 UT and was observed by Hinode , IRIS , SDO , and RHESSI . We analyze a bright kernel that produces a white light (WL) flare with continuum enhancement and a hard X-ray (HXR) peak. Taking advantage of the spectroscopic observations of IRIS and Hinode /EIS, we measure the temporal variation of the plasma properties in the bright kernel in the chromosphere and corona. We find that explosive evaporation was observed when the WL emission occurred, even though the intensity enhancement in hotter lines is quite weak. The temporal correlation of the WL emission, HXR peak, and evaporation flows indicates that the WL emission was produced by accelerated electrons. To understand the WL emission process, we calculated the energy flux deposited by non-thermal electrons (observed by RHESSI ) and compared it to the dissipated energy estimated from a chromospheric line (Mg ii triplet) observed by IRIS . The deposited energy flux from the non-thermal electrons is about (3–7.7) × 10{sup 10} erg cm{sup −2} s{sup −1} for a given low-energy cutoff of 30–40 keV, assuming the thick-target model. The energy flux estimated from the changes in temperature in the chromosphere measured using the Mg ii subordinate line is about (4.6–6.7) × 10{sup 9} erg cm{sup −2} s{sup −1}: ∼6%–22% of the deposited energy. This comparison of estimated energy fluxes implies that the continuum enhancement was directly produced by the non-thermal electrons.

  20. Shallow vent architecture of Puyehue Cordón-Caulle, as revealed by direct observation of explosive activity

    Science.gov (United States)

    Schipper, C. I.; Tuffen, H.; Castro, J. M.

    2012-04-01

    On June 4, 2011, an explosive eruption of rhyodacitic magma began at the Puyehue Cordón-Caulle volcanic complex (PCCVC), southern Chile. Initial Plinian phases of the eruption produced tephra plumes reaching > 14 km high, the ash from which quickly circumnavigated the globe to cause widespread disruption to air traffic in the Southern Hemisphere. Within two weeks, the continuing explosive eruption was joined by synchronous effusion of lava. We present observations of complex vent activity made 7 months after the eruption onset, on January 4th and 10th, 2012, when explosive activity from PCCVC continued at a lower level of intensity. Fortuitous climatic conditions permitted direct, ground-based observation and video recording of transient vent dynamics within the asymmetrical tephra cone around the main eruptive vent complex and site of lava effusion, as well as real-time collection of juvenile ash as it rained out directly from the active plume. On Jan. 4, explosive activity was semi-continuous ash jetting punctuated by Vulcanian-like blasts. In the ~50m-diameter sub-circular base of the ~400 m-wide, asymmetrical tephra cone, near-continuous ash jetting was observed from two primary point sources. The northerly source was clearly visible, with time-averaged diameter of ~10 m, and the apparently larger southerly source was mostly obscured from view by the ash plume. Activity was at all times somewhat erratic, but followed a rough cyclicity on 30-45 s timescales, consisting of: (1) restriction of the point source into a focused ash jet up to ~50 m high, producing coarse ash dominated by tube pumice (with minor free pyroxene crystals); followed by (2) Vulcanian-like failure of the region around the point source, producing incandescent ballistic bombs thrown up to 100-200 m from the vent. Jetting from the two main point sources combined in the crater to produce a low gas-thrust region and sustained buoyant plume. Directed ash plumes that climbed and breached the inner

  1. The impact of patient participation direct enhanced service on patient reference groups in primary care: a qualitative study.

    Science.gov (United States)

    Pollard, Lorraine; Agarwal, Shona; Harrad, Fawn; Lester, Louise; Cross, Ainsley; Wray, Paula; Smith, Gordon; Locke, Anthony; Sinfield, Paul

    2014-01-01

    NHS policy documents continue to make a wide-ranging commitment to patient involvement. The Patient Participation Direct Enhanced Service (PP-DES), launched in 2011, aimed to ensure patients are involved in decisions about the range and quality of services provided and commissioned by their practice through patient reference groups (PRGs). The aim of this exploratory study is to review the impact of the PP-DES (2011-13) on a sample of PRGs and assess how far it has facilitated their involvement in decisions about the services of their general practices. A qualitative methods design, using semi- structured interviews and focus groups, was employed to explore the experiences and views of GP practice staff (n = 24), PRG members (n = 80) at 12 GP practices, and other stakeholders (n = 4). Wide variation in the role and remit of the participating PRGs was found, which broadly ranged from activities to improve practice resources to supporting health promotion activities. The majority of PRG members were unfamiliar with the PP-DES scheme and its aims and purpose. Stakeholders and practice staff felt strongly that the main success of the PP-DES was that it had led to an increase in the number of PRGs being established in the locality. The PP-DES scheme has been a catalyst to establish PRGs. However, the picture was mixed in terms of the PRGs involvement in decisions about the services provided at their general practice as there was wide variation in the PRGs role and remit. The financial incentive alone, provided via the DES scheme, did not secure greater depth of PRG activity and power, however, as social factors were identified as playing an important role in PRGs' level of participation in decision making. Many PRGs have to become more firmly established before they are involved as partners in commissioning decisions at their practice.

  2. Identifying ecological "sweet spots" underlying cyanobacteria functional group dynamics from long-term observations using a statistical machine learning approach

    Science.gov (United States)

    Nelson, N.; Munoz-Carpena, R.; Phlips, E. J.

    2017-12-01

    Diversity in the eco-physiological adaptations of cyanobacteria genera creates challenges for water managers who are tasked with developing appropriate actions for controlling not only the intensity and frequency of cyanobacteria blooms, but also reducing the potential for blooms of harmful taxa (e.g., toxin producers, N2 fixers). Compounding these challenges, the efficacy of nutrient management strategies (phosphorus-only versus nitrogen-and-phosphorus) for cyanobacteria bloom abatement is the subject of an ongoing debate, which increases uncertainty associated with bloom mitigation decision-making. In this work, we analyze a unique long-term (17-year) dataset composed of monthly observations of cyanobacteria genera abundances, zooplankton abundances, water quality, and flow from Lake George, a bloom-impacted flow-through lake of the St. Johns River (FL, USA). Using the Random Forests machine learning algorithm, an assumption-free ensemble modeling approach, the dataset was evaluated to quantify and characterize relationships between environmental conditions and seven cyanobacteria groupings: five genera (Anabaena, Cylindrospermopsis, Lyngbya, Microcystis, and Oscillatoria) and two functional groups (N2 fixers and non-fixers). Results highlight the selectivity of nitrogen in describing genera and functional group dynamics, and potential for physical effects to limit the efficacy of nutrient management as a mechanism for cyanobacteria bloom mitigation.

  3. Direct Observation of 2D Electrostatics and Ohmic Contacts in Template-Grown Graphene/WS2 Heterostructures.

    Science.gov (United States)

    Zheng, Changxi; Zhang, Qianhui; Weber, Bent; Ilatikhameneh, Hesameddin; Chen, Fan; Sahasrabudhe, Harshad; Rahman, Rajib; Li, Shiqiang; Chen, Zhen; Hellerstedt, Jack; Zhang, Yupeng; Duan, Wen Hui; Bao, Qiaoliang; Fuhrer, Michael S

    2017-03-28

    Large-area two-dimensional (2D) heterojunctions are promising building blocks of 2D circuits. Understanding their intriguing electrostatics is pivotal but largely hindered by the lack of direct observations. Here graphene-WS 2 heterojunctions are prepared over large areas using a seedless ambient-pressure chemical vapor deposition technique. Kelvin probe force microscopy, photoluminescence spectroscopy, and scanning tunneling microscopy characterize the doping in graphene-WS 2 heterojunctions as-grown on sapphire and transferred to SiO 2 with and without thermal annealing. Both p-n and n-n junctions are observed, and a flat-band condition (zero Schottky barrier height) is found for lightly n-doped WS 2 , promising low-resistance ohmic contacts. This indicates a more favorable band alignment for graphene-WS 2 than has been predicted, likely explaining the low barriers observed in transport experiments on similar heterojunctions. Electrostatic modeling demonstrates that the large depletion width of the graphene-WS 2 junction reflects the electrostatics of the one-dimensional junction between two-dimensional materials.

  4. Direct Observation of Double Hydrogen Transfer via Quantum Tunneling in a Single Porphycene Molecule on a Ag(110) Surface.

    Science.gov (United States)

    Koch, Matthias; Pagan, Mark; Persson, Mats; Gawinkowski, Sylwester; Waluk, Jacek; Kumagai, Takashi

    2017-09-13

    Quantum tunneling of hydrogen atoms (or protons) plays a crucial role in many chemical and biological reactions. Although tunneling of a single particle has been examined extensively in various one-dimensional potentials, many-particle tunneling in high-dimensional potential energy surfaces remains poorly understood. Here we present a direct observation of a double hydrogen atom transfer (tautomerization) within a single porphycene molecule on a Ag(110) surface using a cryogenic scanning tunneling microscope (STM). The tautomerization rates are temperature independent below ∼10 K, and a large kinetic isotope effect (KIE) is observed upon substituting the transferred hydrogen atoms by deuterium, indicating that the process is governed by tunneling. The observed KIE for three isotopologues and density functional theory calculations reveal that a stepwise transfer mechanism is dominant in the tautomerization. It is also found that the tautomerization rate is increased by vibrational excitation via an inelastic electron tunneling process. Moreover, the STM tip can be used to manipulate the tunneling dynamics through modification of the potential landscape.

  5. Group participants' experiences of a patient-directed group-based education program for the management of type 2 diabetes mellitus.

    Science.gov (United States)

    Odgers-Jewell, Kate; Isenring, Elisabeth A; Thomas, Rae; Reidlinger, Dianne P

    2017-01-01

    The objective of this study was to explore the experiences of individuals who participated in a group-based education program, including their motivators in relation to their diabetes management, and the perceived impact of group interactions on participants' experiences and motivation for self-management. Understanding individuals diagnosed with diabetes experiences of group-based education for the management of type 2 diabetes mellitus may guide the development and facilitation of these programs. Semi-structured interviews were conducted with all individuals who participated in the intervention. Using thematic analysis underpinned by self-determination theory, we developed themes that explored participants' motivators in relation to diabetes management and the impact of group interactions on their experiences and motivation. The key themes included knowledge, experience, group interactions and motivation. Participants perceived that the group interactions facilitated further learning and increased motivation, achieved through normalization, peer identification or by talking with, and learning from the experience of others. The results support the use of patient-centred programs that prioritize group interactions over the didactic presentation of content, which may address relevant psychological needs of people diagnosed with type 2 diabetes mellitus, and improve their motivation and health behaviours. Future group-based education programs may benefit from the use of self-determination theory as a framework for intervention design to enhance participant motivation.

  6. Observations of environmental quenching in groups in the 11 Gyr since z = 2.5: Different quenching for central and satellite galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Tal, Tomer; Illingworth, Garth D.; Magee, Daniel [UCO/Lick Observatory, University of California, Santa Cruz, CA 95064 (United States); Dekel, Avishai [Racah Institute of Physics, The Hebrew University, Jerusalem 91904 (Israel); Oesch, Pascal; Van Dokkum, Pieter G.; Leja, Joel; Momcheva, Ivelina; Nelson, Erica J. [Yale University Astronomy Department, P.O. Box 208101, New Haven, CT 06520-8101 (United States); Muzzin, Adam; Franx, Marijn [Leiden Observatory, Leiden University, NL-2300 RA Leiden (Netherlands); Brammer, Gabriel B. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Marchesini, Danilo [Department of Physics and Astronomy, Tufts University, Medford, MA 02155 (United States); Patel, Shannon G.; Quadri, Ryan F. [Carnegie Observatories, Pasadena, CA 91101 (United States); Rix, Hans-Walter [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany); Skelton, Rosalind E. [South African Astronomical Observatory, Observatory Road, Cape Town (South Africa); Wake, David A. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI 53706 (United States); Whitaker, Katherine E., E-mail: tal@ucolick.org [Astrophysics Science Division, Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2014-07-10

    We present direct observational evidence for star formation quenching in galaxy groups in the redshift range 0 < z < 2.5. We utilize a large sample of nearly 6000 groups, selected by fixed cumulative number density from three photometric catalogs, to follow the evolving quiescent fractions of central and satellite galaxies over roughly 11 Gyr. At z ∼ 0, central galaxies in our sample range in stellar mass from Milky Way/M31 analogs (M{sub *}/M{sub ☉} = 6.5 × 10{sup 10}) to nearby massive ellipticals (M{sub *}/M{sub ☉} = 1.5 × 10{sup 11}). Satellite galaxies in the same groups reach masses as low as twice that of the Large Magellanic Cloud (M{sub *}/M{sub ☉} = 6.5 × 10{sup 9}). Using statistical background subtraction, we measure the average rest-frame colors of galaxies in our groups and calculate the evolving quiescent fractions of centrals and satellites over seven redshift bins. Our analysis shows clear evidence for star formation quenching in group halos, with a different quenching onset for centrals and their satellite galaxies. Using halo mass estimates for our central galaxies, we find that star formation shuts off in centrals when typical halo masses reach between 10{sup 12} and 10{sup 13} M{sub ☉}, consistent with predictions from the halo quenching model. In contrast, satellite galaxies in the same groups most likely undergo quenching by environmental processes, whose onset is delayed with respect to their central galaxy. Although star formation is suppressed in all galaxies over time, the processes that govern quenching are different for centrals and satellites. While mass plays an important role in determining the star formation activity of central galaxies, quenching in satellite galaxies is dominated by the environment in which they reside.

  7. Observations of environmental quenching in groups in the 11 Gyr since z = 2.5: Different quenching for central and satellite galaxies

    International Nuclear Information System (INIS)

    Tal, Tomer; Illingworth, Garth D.; Magee, Daniel; Dekel, Avishai; Oesch, Pascal; Van Dokkum, Pieter G.; Leja, Joel; Momcheva, Ivelina; Nelson, Erica J.; Muzzin, Adam; Franx, Marijn; Brammer, Gabriel B.; Marchesini, Danilo; Patel, Shannon G.; Quadri, Ryan F.; Rix, Hans-Walter; Skelton, Rosalind E.; Wake, David A.; Whitaker, Katherine E.

    2014-01-01

    We present direct observational evidence for star formation quenching in galaxy groups in the redshift range 0 < z < 2.5. We utilize a large sample of nearly 6000 groups, selected by fixed cumulative number density from three photometric catalogs, to follow the evolving quiescent fractions of central and satellite galaxies over roughly 11 Gyr. At z ∼ 0, central galaxies in our sample range in stellar mass from Milky Way/M31 analogs (M * /M ☉ = 6.5 × 10 10 ) to nearby massive ellipticals (M * /M ☉ = 1.5 × 10 11 ). Satellite galaxies in the same groups reach masses as low as twice that of the Large Magellanic Cloud (M * /M ☉ = 6.5 × 10 9 ). Using statistical background subtraction, we measure the average rest-frame colors of galaxies in our groups and calculate the evolving quiescent fractions of centrals and satellites over seven redshift bins. Our analysis shows clear evidence for star formation quenching in group halos, with a different quenching onset for centrals and their satellite galaxies. Using halo mass estimates for our central galaxies, we find that star formation shuts off in centrals when typical halo masses reach between 10 12 and 10 13 M ☉ , consistent with predictions from the halo quenching model. In contrast, satellite galaxies in the same groups most likely undergo quenching by environmental processes, whose onset is delayed with respect to their central galaxy. Although star formation is suppressed in all galaxies over time, the processes that govern quenching are different for centrals and satellites. While mass plays an important role in determining the star formation activity of central galaxies, quenching in satellite galaxies is dominated by the environment in which they reside.

  8. Cervical Proprioception in a Young Population Who Spend Long Periods on Mobile Devices: A 2-Group Comparative Observational Study.

    Science.gov (United States)

    Portelli, Andrew; Reid, Susan A

    2018-02-01

    The purpose of this study was to evaluate if young people with insidious-onset neck pain who spend long periods on mobile electronic devices (known as "text neck") have impaired cervical proprioception and if this is related to time on devices. A 2-group comparative observational study was conducted at an Australian university. Twenty-two participants with text neck and 22 asymptomatic controls, all of whom were 18 to 35 years old and spent ≥4 hours per day on unsupported electronic devices, were assessed using the head repositioning accuracy (HRA) test. Differences between groups were calculated using independent sample t-tests, and correlations between neck pain intensity, time on devices, and HRA test were performed using Pearson's bivariate analysis. During cervical flexion, those with text neck (n = 22, mean age ± standard deviation [SD]: 21 ± 4 years, 59% female) had a 3.9° (SD: 1.4°) repositioning error, and the control group (n = 22, 20 ± 1 years, 68% female) had a 2.9° (SD: 1.2°) error. The mean difference was 1° (95% confidence interval: 0-2, P = .02). For other cervical movements, there was no difference between groups. There was a moderately significant correlation (P ≤ .05) between time spent on electronic devices and cervical pain intensity and between cervical pain intensity and HRA during flexion. The participants with text neck had a greater proprioceptive error during cervical flexion compared with controls. This could be related to neck pain and time spent on electronic devices. Copyright © 2018. Published by Elsevier Inc.

  9. Direct observation of Young’s double-slit interferences in vibrationally resolved photoionization of diatomic molecules

    Science.gov (United States)

    Canton, Sophie E.; Plésiat, Etienne; Bozek, John D.; Rude, Bruce S.; Decleva, Piero; Martín, Fernando

    2011-01-01

    Vibrationally resolved valence-shell photoionization spectra of H2, N2 and CO have been measured in the photon energy range 20–300 eV using third-generation synchrotron radiation. Young’s double-slit interferences lead to oscillations in the corresponding vibrational ratios, showing that the molecules behave as two-center electron-wave emitters and that the associated interferences leave their trace in the angle-integrated photoionization cross section. In contrast to previous work, the oscillations are directly observable in the experiment, thereby removing any possible ambiguity related to the introduction of external parameters or fitting functions. A straightforward extension of an original idea proposed by Cohen and Fano [Cohen HD, Fano U (1966) Phys Rev 150:30] confirms this interpretation and shows that it is also valid for diatomic heteronuclear molecules. Results of accurate theoretical calculations are in excellent agreement with the experimental findings.

  10. First observation of density profile in directly laser-driven polystyrene targets for ablative Rayleigh-Taylor instability research

    International Nuclear Information System (INIS)

    Fujioka, Shinsuke; Shiraga, Hiroyuki; Nishikino, Masaharu; Shigemori, Keisuke; Sunahara, Atsushi; Nakai, Mitsuo; Azechi, Hiroshi; Nishihara, Katsunobu; Yamanaka, Tatsuhiko

    2003-01-01

    The temporal evolution of the density profile of a directly laser-driven polystyrene target was observed for the first time using an x-ray penumbral imaging technique coupled with side-on x-ray backlighting at the GEKKO XII [C. Yamanaka et al., IEEE J. Quantum Electron. QE-17, 1639 (1981)]-High Intensity Plasma Experimental Research laser facility (I L =0.7x10 14 W/cm 2 , λ L =0.35 μm). This density measurement makes it possible to experimentally confirm all physical parameters [γ(k),k,g,m,ρ a ,L m ] appearing in the modified Takabe formula for the growth rate of the ablative Rayleigh-Taylor instability. The measured density profiles were well reproduced by a one-dimensional hydrodynamic simulation code. The density measurement contributes toward fully understanding the ablative Rayleigh-Taylor instability

  11. X-Ray Radiographic Observation of Directional Solidification Under Microgravity: XRMON-GF Experiments on MASER12 Sounding Rocket Mission

    Science.gov (United States)

    Reinhart, G.; NguyenThi, H.; Bogno, A.; Billia, B.; Houltz, Y.; Loth, K.; Voss, D.; Verga, A.; dePascale, F.; Mathiesen, R. H.; hide

    2012-01-01

    The European Space Agency (ESA) - Microgravity Application Promotion (MAP) programme entitled XRMON (In situ X-Ray MONitoring of advanced metallurgical processes under microgravity and terrestrial conditions) aims to develop and perform in situ X-ray radiography observations of metallurgical processes in microgravity and terrestrial environments. The use of X-ray imaging methods makes it possible to study alloy solidification processes with spatio-temporal resolutions at the scales of relevance for microstructure formation. XRMON has been selected for MASER 12 sounding rocket experiment, scheduled in autumn 2011. Although the microgravity duration is typically six minutes, this short time is sufficient to investigate a solidification experiment with X-ray radiography. This communication will report on the preliminary results obtained with the experimental set-up developed by SSC (Swedish Space Corporation). Presented results dealing with directional solidification of Al-Cu confirm the great interest of performing in situ characterization to analyse dynamical phenomena during solidification processes.

  12. Primordial oscillations in life: Direct observation of glycolytic oscillations in individual HeLa cervical cancer cells

    Science.gov (United States)

    Amemiya, Takashi; Shibata, Kenichi; Itoh, Yoshihiro; Itoh, Kiminori; Watanabe, Masatoshi; Yamaguchi, Tomohiko

    2017-10-01

    We report the first direct observation of glycolytic oscillations in HeLa cervical cancer cells, which we regard as primordial oscillations preserved in living cells. HeLa cells starved of glucose or both glucose and serum exhibited glycolytic oscillations in nicotinamide adenine dinucleotide (NADH), exhibiting asynchronous intercellular behaviors. Also found were spatially homogeneous and inhomogeneous intracellular NADH oscillations in the individual cells. Our results demonstrate that starved HeLa cells may be induced to exhibit glycolytic oscillations by either high-uptake of glucose or the enhancement of a glycolytic pathway (Crabtree effect or the Warburg effect), or both. Their asynchronous collective behaviors in the oscillations were probably due to a weak intercellular coupling. Elucidation of the relationship between the mechanism of glycolytic dynamics in cancer cells and their pathophysiological characteristics remains a challenge in future.

  13. Directly observed treatment short course in immunocompetent patients of tuberculous cervical lymphadenopathy treated in revised national tuberculosis control programme

    Directory of Open Access Journals (Sweden)

    Venu Kandala

    2012-01-01

    Full Text Available Background: Prospective observation analysis to evaluate the cure in tuberculous cervical lymphadenopathy with directly observed treatment short course category III (DOTS CAT III treatment as per revised national tuberculosis control program (RNTCP at a tertiary care hospital in AP, India, from October 2007 to September 2009. These cases were followed up for period of 22 months. Materials and Methods: Total 1521 tuberculous cases were screened in KIMS both pulmonary and extra pulmonary cases out of which 146 cases were tuberculous lymphadenitis. Fifty cases of tuberculous cervical lymphadenopathy were included after diagnostic and treatment algorithm and fine needle biopsy or excision biopsy. Patients below 5 yrs, immunocompromised, having diabetes mellitus, pulmonary tuberculosis and with other co-morbid conditions were excluded from the study. All patients were put on DOTS CAT III as per RNTCP guidelines. Follow-up was done every 2 months till 6 months for 1 Constitution symptoms 2 Weight gain or loss 3 Appetite gain or loss 4 Regression of lymph nodes or increase 5 Compliance 6 Side effects 7 Failures by demonstration of organism by direct smear, culture or histopathological examination. Results: In this study, lymph node regression was found in 78% at the end of 2 months, 94% at the end of 4 months and 96% at the end of 6 months, 9 patients had regression in size though the nodes were palpable, 2 had no regression but fresh lymph nodes appeared on the same side and sinus discharge was present, culture was negative in these cases. Two cases had immune reconstitution syndrome, constitutional symptoms disappeared and showed clinical improvement. Four cases were subjected for surgical intervention. Conclusion: DOTS CAT III is effective in the treatment of tuberculous cervical lymphadenopathy. Compliance was good with minimal, minor side effects, only two had immune reconstitution syndrome and two had sinus formation; they were referred for

  14. Direct observation of the carrier transport process in InGaN quantum wells with a pn-junction

    Science.gov (United States)

    Wu, Haiyan; Ma, Ziguang; Jiang, Yang; Wang, Lu; Yang, Haojun; Li, Yangfeng; Zuo, Peng; Jia, Haiqiang; Wang, Wenxin; Zhou, Junming; Liu, Wuming; Chen, Hong

    2016-11-01

    A new mechanism of light-to-electricity conversion that uses InGaN/GaN QWs with a p-n junction is reported. According to the well established light-to-electricity conversion theory, quantum wells (QWs) cannot be used in solar cells and photodetectors because the photogenerated carriers in QWs usually relax to ground energy levels, owing to quantum confinement, and cannot form a photocurrent. We observe directly that more than 95% of the photoexcited carriers escape from InGaN/GaN QWs to generate a photocurrent, indicating that the thermionic emission and tunneling processes proposed previously cannot explain carriers escaping from QWs. We show that photoexcited carriers can escape directly from the QWs when the device is under working conditions. Our finding challenges the current theory and demonstrates a new prospect for developing highly efficient solar cells and photodetectors. Project supported by the National Natural Science Foundation of China (Grant Nos. 11574362, 61210014, and 11374340) and the Innovative Clean-energy Research and Application Program of Beijing Municipal Science and Technology Commission, China (Grant No. Z151100003515001).

  15. Principal component analysis of the main factors of line intensity enhancements observed in oscillating direct current plasma

    International Nuclear Information System (INIS)

    Stoiljkovic, Milovan M.; Pasti, Igor A.; Momcilovic, Milos D.; Savovic, Jelena J.; Pavlovic, Mirjana S.

    2010-01-01

    Enhancement of emission line intensities by induced oscillations of direct current (DC) arc plasma with continuous aerosol sample supply was investigated using multivariate statistics. Principal component analysis (PCA) was employed to evaluate enhancements of 34 atomic spectral lines belonging to 33 elements and 35 ionic spectral lines belonging to 23 elements. Correlation and classification of the elements were done not only by a single property such as the first ionization energy, but also by considering other relevant parameters. Special attention was paid to the influence of the oxide bond strength in an attempt to clarify/predict the enhancement effect. Energies of vaporization, atomization, and excitation were also considered in the analysis. In the case of atomic lines, the best correlation between the enhancements and first ionization energies was obtained as a negative correlation, with weak consistency in grouping of elements in score plots. Conversely, in the case of ionic lines, the best correlation of the enhancements with the sum of the first ionization energies and oxide bond energies was obtained as a positive correlation, with four distinctive groups of elements. The role of the gas-phase atom-oxide bond energy in the entire enhancement effect is underlined.

  16. Efficacy and tolerability of topical sertaconazole versus topical terbinafine in localized dermatophytosis: A randomized, observer-blind, parallel group study.

    Science.gov (United States)

    Chatterjee, Dattatreyo; Ghosh, Sudip Kumar; Sen, Sukanta; Sarkar, Saswati; Hazra, Avijit; De, Radharaman

    2016-01-01

    Epidermal dermatophyte infections most commonly manifest as tinea corporis or tinea cruris. Topical azole antifungals are commonly used in their treatment but literature suggests that most require twice-daily application and provide lower cure rates than the allylamine antifungal terbinafine. We conducted a head-to-head comparison of the effectiveness of the once-daily topical azole, sertaconazole, with terbinafine in these infections. We conducted a randomized, observer-blind, parallel group study (Clinical Trial Registry India [CTRI]/2014/09/005029) with adult patients of either sex presenting with localized lesions. The clinical diagnosis was confirmed by potassium hydroxide smear microscopy of skin scrapings. After baseline assessment of erythema, scaling, and pruritus, patients applied either of the two study drugs once daily for 2 weeks. If clinical cure was not seen at 2 weeks, but improvement was noted, application was continued for further 2 weeks. Patients deemed to be clinical failure at 2 weeks were switched to oral antifungals. Overall 88 patients on sertaconazole and 91 on terbinafine were analyzed. At 2 weeks, the clinical cure rates were comparable at 77.27% (95% confidence interval [CI]: 68.52%-86.03%) for sertaconazole and 73.63% (95% CI 64.57%-82.68%) for terbinafine ( P = 0.606). Fourteen patients in either group improved and on further treatment showed complete healing by another 2 weeks. The final cure rate at 4 weeks was also comparable at 93.18% (95% CI 88.75%-97.62%) and 89.01% (95% CI 82.59%-95.44%), respectively ( P = 0.914). At 2 weeks, 6 (6.82%) sertaconazole and 10 (10.99%) terbinafine recipients were considered as "clinical failure." Tolerability of both preparations was excellent. Despite the limitations of an observer-blind study without microbiological support, the results suggest that once-daily topical sertaconazole is as effective as terbinafine in localized tinea infections.

  17. Observer-Based Perturbation Extremum Seeking Control with Input Constraints for Direct-Contact Membrane Distillation Process

    KAUST Repository

    Eleiwi, Fadi

    2017-05-08

    An Observer-based Perturbation Extremum Seeking Control (PESC) is proposed for a Direct-Contact Membrane Distillation (DCMD) process. The process is described with a dynamic model that is based on a 2D Advection-Diffusion Equation (ADE) model which has pump flow rates as process inputs. The objective of the controller is to optimize the trade-off between the permeate mass flux and the energy consumption by the pumps inside the process. Cases of single and multiple control inputs are considered through the use of only the feed pump flow rate or both the feed and the permeate pump flow rates. A nonlinear Lyapunov-based observer is designed to provide an estimation for the temperature distribution all over the designated domain of the DCMD process. Moreover, control inputs are constrained with an anti-windup technique to be within feasible and physical ranges. Performance of the proposed structure is analyzed, and simulations based on real DCMD process parameters for each control input are provided.

  18. Letter to the Editor: First direct observations of the reduced striations at pump frequencies close to the electron gyroharmonics

    Directory of Open Access Journals (Sweden)

    M. T. Rietveld

    Full Text Available It is well known that the ionospheric plasma response to high-power HF radio waves changes drastically as the heater frequency approaches harmonics of the electron gyrofrequency. These include changes in the spectrum of the stimulated electromagnetic emission, reduction in the anomalous absorption of low-power diagnostic waves propagating through the heated volume, and reduction in the large scale F-region heating. Theoretical models as well as previous experimental evidence point towards the absence of small-scale field-aligned plasma density irregularities at pump frequencies close to electron gyroharmonics as the main cause of these changes. Results presented in this paper are the first direct observations of the reduced striations at the 3rd gyroharmonic made by the CUTLASS radar. In addition, simultaneous EISCAT observations have revealed that the "enhanced ion-line" usually present in the EISCAT ion-line spectrum during the first few seconds after heater switch on, persisted at varying strengths while the heater was transmitting at frequencies close to the 3rd electron gyroharmonics.Key words. Ionosphere (active experiments; ionospheric irregularities · Radio science (ionospheric physics

  19. Letter to the Editor: First direct observations of the reduced striations at pump frequencies close to the electron gyroharmonics

    Directory of Open Access Journals (Sweden)

    F. Honary

    1999-09-01

    Full Text Available It is well known that the ionospheric plasma response to high-power HF radio waves changes drastically as the heater frequency approaches harmonics of the electron gyrofrequency. These include changes in the spectrum of the stimulated electromagnetic emission, reduction in the anomalous absorption of low-power diagnostic waves propagating through the heated volume, and reduction in the large scale F-region heating. Theoretical models as well as previous experimental evidence point towards the absence of small-scale field-aligned plasma density irregularities at pump frequencies close to electron gyroharmonics as the main cause of these changes. Results presented in this paper are the first direct observations of the reduced striations at the 3rd gyroharmonic made by the CUTLASS radar. In addition, simultaneous EISCAT observations have revealed that the "enhanced ion-line" usually present in the EISCAT ion-line spectrum during the first few seconds after heater switch on, persisted at varying strengths while the heater was transmitting at frequencies close to the 3rd electron gyroharmonics.Key words. Ionosphere (active experiments; ionospheric irregularities · Radio science (ionospheric physics

  20. Direct Torque Control with Full Order Stator Flux Observer for Dual-Three Phase Induction Motor Drives

    Science.gov (United States)

    Farina, Francesco; Bojoi, Radu; Tenconi, Alberto; Profumo, Francesco

    A Direct Torque Control (DTC) strategy for dual-three phase induction motor drives is discussed in this paper. The induction machine has two sets of stator three-phase windings spatially shifted by 30 electrical degrees with isolated neutral points. The proposed control strategy is based on Proportional Integral (PI) regulators implemented in the stator flux synchronous reference frame. To improve the flux estimation, an Adaptive Stator Flux Observer (ASFO) has been used. Doing so, besides a better flux estimation in contrast to open-loop flux estimators, it is possible to use the observed currents to compensate the inverter non-linear behavior (such as dead-time effects), improving the drive performance at low speed. This is particularly important for low voltage/high current applications, as the drive considered in this paper. The advantages of the discussed control strategy are: constant inverter switching frequency, good transient and steady-state performance and less distorted machine currents in contrast to DTC schemes with variable switching frequency. Experimental results are presented for a 10kW dual three-phase induction motor drive prototype.

  1. Observer-based perturbation extremum seeking control with input constraints for direct-contact membrane distillation process

    Science.gov (United States)

    Eleiwi, Fadi; Laleg-Kirati, Taous Meriem

    2018-06-01

    An observer-based perturbation extremum seeking control is proposed for a direct-contact membrane distillation (DCMD) process. The process is described with a dynamic model that is based on a 2D advection-diffusion equation model which has pump flow rates as process inputs. The objective of the controller is to optimise the trade-off between the permeate mass flux and the energy consumption by the pumps inside the process. Cases of single and multiple control inputs are considered through the use of only the feed pump flow rate or both the feed and the permeate pump flow rates. A nonlinear Lyapunov-based observer is designed to provide an estimation for the temperature distribution all over the designated domain of the DCMD process. Moreover, control inputs are constrained with an anti-windup technique to be within feasible and physical ranges. Performance of the proposed structure is analysed, and simulations based on real DCMD process parameters for each control input are provided.

  2. Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ

    Science.gov (United States)

    Bolla, Jani Reddy; Sauer, Joshua B.; Wu, Di; Mehmood, Shahid; Allison, Timothy M.; Robinson, Carol V.

    2018-03-01

    Translocation of lipid II across the cytoplasmic membrane is essential in peptidoglycan biogenesis. Although most steps are understood, identifying the lipid II flippase has yielded conflicting results, and the lipid II binding properties of two candidate flippases—MurJ and FtsW—remain largely unknown. Here we apply native mass spectrometry to both proteins and characterize lipid II binding. We observed lower levels of lipid II binding to FtsW compared to MurJ, consistent with MurJ having a higher affinity. Site-directed mutagenesis of MurJ suggests that mutations at A29 and D269 attenuate lipid II binding to MurJ, whereas chemical modification of A29 eliminates binding. The antibiotic ramoplanin dissociates lipid II from MurJ, whereas vancomycin binds to form a stable complex with MurJ:lipid II. Furthermore, we reveal cardiolipins associate with MurJ but not FtsW, and exogenous cardiolipins reduce lipid II binding to MurJ. These observations provide insights into determinants of lipid II binding to MurJ and suggest roles for endogenous lipids in regulating substrate binding.

  3. DIRECT OBSERVATIONS OF TETHER-CUTTING RECONNECTION DURING A MAJOR SOLAR EVENT FROM 2014 FEBRUARY 24 TO 25

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Huadong; Zhang, Jun; Yang, Shuhong; Li, Ting [Key Laboratory of Solar Activity, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Cheng, Xin [School of Astronomy and Space Science, Nanjing University, Nanjing 210093 (China); Ma, Suli, E-mail: hdchen@nao.cas.cn [College of Science, China University of Petroleum, Qingdao 266580 (China)

    2014-12-20

    Using multi-wavelength data from the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory, we investigated two successive solar flares, a C5.1 confined flare and an X4.9 ejective flare with a halo coronal mass ejection, in NOAA active region 11990 from 2014 February 24 to 25. Before the confined flare onset, EUV brightening beneath the filament was detected. As the flare began, a twisted helical flux rope (FR) wrapping around the filament moved upward and then stopped, and in the meantime an obvious X-ray source below it was observed. Prior to the ejective X4.9 flare, some pre-existing loop structures in the active region interacted with each other, which produced a brightening region beneath the filament. Meanwhile, a small flaring loop appeared below the interaction region and some new helical lines connecting the far ends of the loop structures were gradually formed and continually added into the former twisted FR. Then, due to the resulting imbalance between the magnetic pressure and tension, the new FR, together with the filament, erupted outward. Our observations coincide well with a tether-cutting model, suggesting that the two flares probably have the same triggering mechanism, i.e., tether-cutting reconnection. To our knowledge, this is the first direct observation of tether-cutting reconnection occurring between pre-existing loops in an active region. In the ejective flare case, the erupting filament exhibited an Ω-like kinked structure and underwent an exponential rise after a slow-rise phase, indicating that the kink instability might be also responsible for the eruption initiation.

  4. Prediction of SEP Peak Proton Intensity Based on CME Speed, Direction and Observations of Associated Solar Phenomena

    Science.gov (United States)

    Richardson, I. G.; Mays, M. L.; Thompson, B. J.; Kwon, R.; Frechette, B. P.

    2017-12-01

    We assess whether a formula obtained by Richardson et al. (Solar Phys., 289, 3059, 2014; DOI 10.1007/s11207-014-0524-8) relating the intensity of 14-24 MeV protons in a solar energetic particle event at 1 AU to the solar event location and the speed of the associated coronal mass ejection (CME), may be used to "predict" the intensity of a solar energetic particle event. Starting with a subset of several hundred CMEs in the CCMC/SWRC DONKI real-time database (http://kauai.ccmc.gsfc.nasa.gov/DONKI/) selected without consideration of whether they were associated with SEP events, we first use the CME speed and direction to predict the proton intensity at Earth or the STEREO spacecraft using this formula. Since most of these CMEs were not in fact associated with SEP events, many "false alarms" result. We then examine whether considering other phenomena which may accompany the CMEs, such as the X-ray flare intensity and the properties of type II and type III radio emissions, may help to reduce the false alarm rate. We also use CME parameters calculated from an ellipsoidal shell fit to multi-spacecraft CME shock observations for a smaller number of events to predict the SEP intensity. We calculate skill scores for each case and assess whether the Richardson et al. (2014) formula, using additional observations to reduce the false alarm rate, has any potential as a SEP prediction tool, assuming that the required observations could be acquired sufficiently rapidly following the onset of the related solar event/CME.

  5. Advancing Patient-Centered Care in Tuberculosis Management: A Mixed-Methods Appraisal of Video Directly Observed Therapy.

    Science.gov (United States)

    Holzman, Samuel B; Zenilman, Avi; Shah, Maunank

    2018-04-01

    Directly observed therapy (DOT) remains an integral component of treatment support and adherence monitoring in tuberculosis care. In-person DOT is resource intensive and often burdensome for patients. Video DOT (vDOT) has been proposed as an alternative to increase treatment flexibility and better meet patient-specific needs. We conducted a pragmatic, prospective pilot implementation of vDOT at 3 TB clinics in Maryland. A mixed-methods approach was implemented to assess (1) effectiveness, (2) acceptability, and (3) cost. Medication adherence on vDOT was compared with that of in-person DOT. Interviews and surveys were conducted with patients and providers before and after implementation, with framework analysis utilized to extract salient themes. Last, a cost analysis assessed the economic impacts of vDOT implementation across heterogeneous clinic structures. Medication adherence on vDOT was comparable to that of in-person DOT (94% vs 98%, P = .17), with a higher percentage of total treatment doses (inclusive of weekend/holiday self-administration) ultimately observed during the vDOT period (72% vs 66%, P = .03). Video DOT was well received by staff and patients alike, who cited increased treatment flexibility, convenience, and patient privacy. Our cost analysis estimated a savings with vDOT of $1391 per patient for a standard 6-month treatment course. Video DOT is an acceptable and important option for measurement of TB treatment adherence and may allow a higher proportion of prescribed treatment doses to be observed, compared with in-person DOT. Video DOT may be cost-saving and should be considered as a component of individualized, patient-centered case management plans.

  6. Direct Measurements of Energy Transfer between Hot Protons and He+ via EMIC Waves Observed by MMS in the Outer Magnetosphere

    Science.gov (United States)

    Kitamura, N.; Kitahara, M.; Shoji, M.; Miyoshi, Y.; Hasegawa, H.; Nakamura, S.; Katoh, Y.; Saito, Y.; Yokota, S.; Gershman, D. J.; Vinas, A. F.; Giles, B. L.; Moore, T. E.; Paterson, W.; Pollock, C. J.; Russell, C. T.; Strangeway, R. J.; Fuselier, S. A.; Burch, J. L.

    2017-12-01

    Wave-particle interactions have been suggested to play a crucial role in energy transfer in collisionless space plasmas in which the motion of charged particles is controlled by electromagnetic fields. Using an electromagnetic ion cyclotron (EMIC) wave event observed by MMS, we investigate energy transfer between ions and EMIC waves via cyclotron type interactions. To directly detect energy exchange between ions and EMIC waves, we apply the Wave-Particle Interaction Analyzer (WPIA) method that is to calculate the dot product between the wave electric field (Ewave) and ion current perpendicular to the background magnetic field (j). In the cases of resonance, this current is called the resonant current. Near the beginning of the wave event, 15-second averages of j • Ewave reached -0.3 pW/m3 for ions with energies of 14-30 keV and pitch angles of 33.25°-78.75°. The negative value in this pitch angle range indicates that the perpendicular energy of ions was being transferred to the EMIC waves propagating toward Southern higher latitudes at the MMS location by cyclotron resonance. Ion data show non-gyrotropic distributions around the resonance velocity, and that is consistent with the nonlinear trapping of protons by the wave and formation of an electromagnetic proton hole. Near the beginning of the same wave event, strongly phase bunched He+ up to 2 keV with pitch angles slightly larger than 90° were also detected. A positive j • Ewave for the phase bunched He+ indicates that the He+ was being accelerated by the electric field of the EMIC waves. The observed feature of He+ ions is consistent with non-resonant interaction with the wave but is inconsistent with cyclotron resonance. Significantly non-gyrotropic distributions observed in this event demonstrate that different particle populations can strongly couple through wave-particle interactions in the collisionless plasma.

  7. Status of direct containment heating in CSNI member countries. Report of task group on ex-vessel thermal-hydraulics

    International Nuclear Information System (INIS)

    1989-03-01

    The status of activities on direct containment heating in the light water reactor program in OECD/CSNI countries is presented. Experimental and analytical studies are reviewed. Approaches or measures are discussed for accident management in relation to direct containment heating. A discussion is given of common and diverging views among the countries based, in part, on response to a questionnaire. The key issues are discussed and recommendations are provided for future CSNI work on direct containment heating

  8. Direct Observation of Room-Temperature Stable Magnetism in LaAlO3/SrTiO3 Heterostructures.

    Science.gov (United States)

    Yang, Ming; Ariando; Zhou, Jun; Asmara, Teguh Citra; Krüger, Peter; Yu, Xiao Jiang; Wang, Xiao; Sanchez-Hanke, Cecilia; Feng, Yuan Ping; Venkatesan, T; Rusydi, Andrivo

    2018-03-21

    Along with an unexpected conducting interface between nonmagnetic insulating perovskites LaAlO 3 and SrTiO 3 (LaAlO 3 /SrTiO 3 ), striking interfacial magnetisms have been observed in LaAlO 3 /SrTiO 3 heterostructures. Interestingly, the strength of the interfacial magnetic moment is found to be dependent on oxygen partial pressures during the growth process. This raises an important, fundamental question on the origin of these remarkable interfacial magnetic orderings. Here, we report a direct evidence of room-temperature stable magnetism in a LaAlO 3 /SrTiO 3 heterostructure prepared at high oxygen partial pressure by using element-specific soft X-ray magnetic circular dichroism at both Ti L 3,2 and O K edges. By combining X-ray absorption spectroscopy at both Ti L 3,2 and O K edges and first-principles calculations, we qualitatively ascribe that this strong magnetic ordering with dominant interfacial Ti 3+ character is due to the coexistence of LaAlO 3 surface oxygen vacancies and interfacial (Ti Al -Al Ti ) antisite defects. On the basis of this new understanding, we revisit the origin of the weak magnetism in LaAlO 3 /SrTiO 3 heterostructures prepared at low oxygen partial pressures. Our calculations show that LaAlO 3 surface oxygen vacancies are responsible for the weak magnetism at the interface. Our result provides direct evidence on the presence of room-temperature stable magnetism and a novel perspective to understand magnetic and electronic reconstructions at such strategic oxide interfaces.

  9. Optical spectroscopy of an atomic nucleus: Progress toward direct observation of the {sup 229}Th isomer transition

    Energy Technology Data Exchange (ETDEWEB)

    Hehlen, Markus P., E-mail: hehlen@lanl.gov [Los Alamos National Laboratory, Mailstop E549, Los Alamos, NM 87545 (United States); Greco, Richard R. [Los Alamos National Laboratory, Mailstop E549, Los Alamos, NM 87545 (United States); Rellergert, Wade G.; Sullivan, Scott T. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States); DeMille, David [Department of Physics, Yale University, New Haven, CT 06511 (United States); Jackson, Robert A. [School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire ST5 5BG (United Kingdom); Hudson, Eric R. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States); Torgerson, Justin R. [Los Alamos National Laboratory, Mailstop E549, Los Alamos, NM 87545 (United States)

    2013-01-15

    The nucleus of the thorium-229 isotope possesses a first excited nuclear state ({sup 229m}Th) at an exceptionally low energy of 7.8{+-}0.5 eV above the nuclear ground state ({sup 229g}Th), as determined by earlier indirect measurements. This is the only nuclear excited state known that is within the range of optical spectroscopy. This paper reports progress toward detecting the {sup 229m}Th state directly by luminescence spectroscopy in the vacuum ultraviolet spectral region. The estimated natural linewidth of the {sup 229g}Th{r_reversible}{sup 229m}Th isomer transition of 2{pi} Multiplication-Sign 0.1 to 2{pi} Multiplication-Sign 10 mHz is expected to broaden to {approx}10 kHz for {sup 229}Th{sup 4+} doped into a suitable crystal. The factors governing the choice of crystal system and the substantial challenges in acquiring a sufficiently large quantity of {sup 229}Th are discussed. We show that the {sup 229g}Th{r_reversible}{sup 229m}Th transition energy can be identified to within 0.1 nm by luminescence excitation and luminescence spectroscopy using the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory. This would open the door for subsequent laser-based measurements of the isomer transition and future applications of {sup 229}Th in nuclear clocks. We also show that {sup 233}U-doped materials should produce an intrinsic, continuous, and sufficiently high rate of {sup 229m}Th{yields}{sup 229g}Th luminescence and could be a useful aid in the initial direct search of the isomer transition. - Highlights: Black-Right-Pointing-Pointer Thorium-229 has a long-lived nuclear excited state. Black-Right-Pointing-Pointer It is the only known nuclear isomer within the reach of optical spectroscopy. Black-Right-Pointing-Pointer Thorium-229 doped fluoride crystals may offer sufficiently high luminescence rates. Black-Right-Pointing-Pointer Luminescence excitation spectroscopy in the vacuum ultraviolet spectral region may enable the first direct observation of

  10. Influence of patient symptoms and physical findings on general practitioners' treatment of respiratory tract infections: a direct observation study

    Directory of Open Access Journals (Sweden)

    Kochen Michael M

    2005-02-01

    Full Text Available Abstract Background The high rate of antibiotic prescriptions general practitioners (GPs make for respiratory tract infections (RTI are often explained by non-medical reasons e.g. an effort to meet patient expectations. Additionally, it is known that GPs to some extent believe in the necessity of antibiotic treatment in patients with assumed bacterial infections and therefore attempt to distinguish between viral and bacterial infections by history taking and physical examination. The influence of patient complaints and physical examination findings on GPs' prescribing behaviour was mostly investigated by indirect methods such as questionnaires. Methods Direct, structured observation during a winter "cough an cold period" in 30 (single handed general practices. All 273 patients with symptoms of RTI (age above 14, median 37 years, 51% female were included. Results The most frequent diagnoses were 'uncomplicated upper RTI/common cold' (43% followed by 'bronchitis' (26%. On average, 1.8 (95%-confidence interval (CI: 1.7–2.0 medicines per patient were prescribed (cough-and-cold preparations in 88% of the patients, antibiotics in 49%. Medical predictors of antibiotic prescribing were pathological findings in physical examination such as coated tonsils (odds ratio (OR 15.4, 95%-CI: 3.6–66.2 and unspecific symptoms like fatigue (OR 3.1, 95%-CI 1.4–6.7, fever (OR 2.2, 95%-CI: 1.1–4.5 and yellow sputum (OR 2.1, 95%-CI: 1.1–4.1. Analysed predictors explained 70% of the variance of antibiotic prescribing (R2 = 0,696. Efforts to reduce antibiotic prescribing, e.g. recommendations for self-medication, counselling on home remedies or delayed antibiotic prescribing were rare. Conclusions Patient complaints and pathological results in physical examination were strong predictors of antibiotic prescribing. Efforts to reduce antibiotic prescribing should account for GPs' beliefs in those (non evidence based predictors. The method of direct observation was

  11. Multicomponent Synthesis of Isoindolinone Frameworks via RhIII -Catalysed in situ Directing Group-Assisted Tandem Oxidative Olefination/Michael Addition.

    Science.gov (United States)

    Wang, Liang; Liu, Xi; Liu, Jian-Biao; Shen, Jun; Chen, Qun; He, Ming-Yang

    2018-04-04

    A Rh III -catalysed three-component synthesis of isoindolinone frameworks via direct assembly of benzoyl chlorides, o-aminophenols and activated alkenes has been developed. The process involves in situ generation of o-aminophenol (OAP)-based bidentate directing group (DG), Rh III -catalysed tandem ortho C-H olefination and subsequent cyclization via aza-Michael addition. This protocol exhibits good chemoselectivity and functional group tolerance. Computational studies showed that the presence of hydroxyl group on the N-aryl ring could enhance the chemoselectivity of the reaction. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. New Observations of Seismic Group Velocities in the Western Solomon Islands from Cross-Correlation of Ambient Seismic Noise

    Science.gov (United States)

    Ku, C. S.; You, S. H.; Kuo, Y. T.; Huang, B. S.; Wu, Y. M.; Chen, Y. G.; Taylor, F. W.

    2015-12-01

    A MW 8.1 earthquake occurred on 1 April 2007 in the western Solomon Islands. Following this event, a damaging tsunami was induced and hit the Island Gizo where the capital city of Western Province of Solomon Islands located. Several buildings of this city were destroyed and several peoples lost their lives during this earthquake. However, during this earthquake, no near source seismic instrument has been installed in this region. The seismic evaluations for the aftershock sequence, the possible earthquake early warning and tsunami warning were unavailable. For the purpose of knowing more detailed information about seismic activity in this region, we have installed 9 seismic stations (with Trillium 120PA broadband seismometer and Q330S 24bit digitizer) around the rupture zone of the 2007 earthquake since September of 2009. Within a decade, it has been demonstrated both theoretically and experimentally that the Green's function or impulse response between two seismic stations can be retrieved from the cross-correlation of ambient noise. In this study, 6 stations' observations which are more complete during 2011/10 ~ 2012/12 period, were selected for the purpose of the cross-correlation analysis of ambient seismic noise. The group velocities at period 2-20 seconds of 15 station-pairs were extracted by using multiple filter technique (MFT) method. The analyzed results of this study presented significant results of group velocities with higher frequency contents than other studies (20-60 seconds in usually cases) and opened new opportunities to study the shallow crustal structure of the western Solomon Islands.

  13. Direct Oral Anticoagulant- or Warfarin-Related Major Bleeding: Characteristics, Reversal Strategies, and Outcomes From a Multicenter Observational Study.

    Science.gov (United States)

    Xu, Yan; Schulman, Sam; Dowlatshahi, Dar; Holbrook, Anne M; Simpson, Christopher S; Shepherd, Lois E; Wells, Philip S; Giulivi, Antonio; Gomes, Tara; Mamdani, Muhammad; Khuu, Wayne; Frymire, Eliot; Johnson, Ana P

    2017-07-01

    Direct oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin effects were reversed in bleeding events. Red blood cell transfusions occurred more often in DOAC bleeding events than in warfarin events (52.0% vs 39.5%; adjusted relative risk [aRR], 1.32; 95% CI, 1.19-2.47). However, units of blood products transfused were not different between the two groups. Thirty-four DOAC cases (7.4%) received activated prothrombin complex concentrates or recombinant factor VIIa. In-hospital mortality was lower following DOAC bleeding events (9.8% vs 15.2%; aRR, 0.66; 95% CI, 0.49-0.89), although differences in 30-day mortality did not reach statistical significance (12.6% vs 16.3%; aRR, 0.79; 95% CI, 0.61-1.03). In this unselected cohort of patients with oral anticoagulant-related hemorrhage with high rates of warfarin reversal, in-hospital mortality was lower among DOAC-associated bleeding events. These findings support the safety of DOACs in routine care and present useful baseline measures for evaluations of DOAC-specific reversal agents. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  14. A prospective study of ocular toxicity in patients receiving ethambutol as a part of directly observed treatment strategy therapy

    Directory of Open Access Journals (Sweden)

    Pragati Garg

    2015-01-01

    Full Text Available Background and Objectives: India is among the largest countries to implement the revised National Tuberculosis Control Program (RNTCP. This program provides intermittent regimens to the patients, where the doses of isoniazid and ethambutol are more as compared to the daily regimen, which is a cause of concern, particularly with regard to the ocular toxicity of ethambutol. The present study was undertaken to explore the ocular toxicity in the patients registered under the program. Materials and Methods: This was a prospective single center cohort study of 64 patients of categories I and II, coming to the RNTCP-Directly Observed Treatment Strategy (DOTS center at a tertiary care referral hospital. The detailed history, best corrected visual acuity, fundus examination, and color vision test were carried out in all patients at the start of treatment and then at the first and second month of treatment. Results: Loss in visual acuity from the baseline was noted at the second month follow up in 12 (9.4% eyes (P = 0.001, visual field defects were seen in eight (6.3% eyes (P = 0.0412, and optic disc abnormalities were observed in six (4.7% (P = 0.013 eyes. Color vision abnormalities were noted in 16 (12.6% eyes (P = 0.003, four eyes showed impairment in red-green color perception, and the others showed impairment in blue-yellow color perception as well. Patients with ocular symptoms were advised to stop ethambutol and they showed improvement in visual acuity after follow up of one to two months. The overall outcome of treatment was not affected by discontinuation of ethambutol in these patients. Conclusion: Ethambutol when taken according to program could cause ocular toxicity. The early recognition of ocular symptoms is important to prevent unnecessary delay in diagnosis and probable irreversible visual loss.

  15. Identification and characterization of the direct interaction between methotrexate (MTX and high-mobility group box 1 (HMGB1 protein.

    Directory of Open Access Journals (Sweden)

    Yuki Kuroiwa

    Full Text Available BACKGROUND: Methotrexate (MTX is an agent used in chemotherapy of tumors and autoimmune disease including rheumatoid arthritis (RA. In addition, MTX has some anti-inflammatory activity. Although dihydrofolate reductase (DHFR is a well-known target for the anti-tumor effect of MTX, the mode of action for the anti-inflammatory activity of MTX is not fully understood. METHODOLOGY/RESULT: Here, we performed a screening of MTX-binding proteins using T7 phage disp