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Sample records for graniteville sc train

  1. Detailed Numerical Simulation of the Graniteville Train Collision

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, R. L.

    2005-10-24

    An unfortunate accident occurred in Graniteville, South Carolina on 6 January, 2005 when a train carrying a variety of hazardous chemicals collided with a stationary train parked on a siding rail (spur). The Savannah River National Laboratory (SRNL) runs prognostic atmospheric simulations of the Central Savannah River Area (CSRA) on an operational basis in the event of such airborne releases. Although forecast information was provided at 2-km horizontal grid spacing during the accident response, a higher-resolution simulation was later performed to examine influences of local topography on plume migration. The Regional Atmospheric Modeling System (RAMS, version 4.3.0) was used to simulate meteorology using multiple grids with an innermost grid spacing of 125 meters. This report discusses comparisons of simulated meteorology with local observations and applications using two separate transport models. Results from the simulations are shown to generally agree with meteorological observations at the time. Use of a dense gas model to simulate localized effects indicates agreement with fatalities in the immediate area and visible damage to vegetation.

  2. Management of chlorine gas-related injuries from the Graniteville, South Carolina, train derailment.

    Science.gov (United States)

    Mackie, Emily; Svendsen, Erik; Grant, Stephen; Michels, Jill E; Richardson, William H

    2014-10-01

    A widely produced chemical, chlorine is used in various industries including automotive, electronics, disinfectants, metal production, and many others. Chlorine is usually produced and transported as a pressurized liquid; however, as a gas it is a significant pulmonary irritant. Thousands of people are exposed to chlorine gas every year, and while large-scale exposures are uncommon, they are not rare. Symptoms are usually related to the concentration and length of exposure, and although treatment is largely supportive, certain specific therapies have yet to be validated with randomized controlled trials. The majority of those exposed completely recover with supportive care; however, studies have shown the potential for persistent inflammation and chronic hyperreactivity. This case report describes an incident that occurred in Graniteville, South Carolina, when a train derailment exposed hundreds of people to chlorine gas. This report reviews the events of January 6, 2005, and the current treatment options for chlorine gas exposure.(Disaster Med Public Health Preparedness. 2014;0:1-6).

  3. MODELING DISPERSION FROM CHEMICALS RELEASED AFTER A TRAIN COLLISION IN GRANITEVILLE, SOUTH CAROLINA

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, R; Chuck Hunter, C; Robert Addis, R; Matt Parker, M

    2006-08-07

    The Savannah River National Laboratory's (SRNL) Weather INformation and Display (WIND) System was used to provide meteorological and atmospheric modeling/consequence assessment support to state and local agencies following the collision of two Norfolk Southern freight trains on the morning of January 6, 2005. This collision resulted in the release of several toxic chemicals to the environment, including chlorine. The dense and highly toxic cloud of chlorine gas that formed in the vicinity of the accident was responsible for nine fatalities, and caused injuries to more than five hundred others. Transport model results depicting the forecast path of the ongoing release were made available to emergency managers in the county's Unified Command Center shortly after SRNL received a request for assistance. Support continued over the ensuing two days of the active response. The SRNL also provided weather briefings and transport/consequence assessment model results to responders from South Carolina Department of Health and Environmental Control (SCDHEC), the Savannah River Site's (SRS) Emergency Operations Center (EOC), Department of Energy Headquarters, and hazmat teams dispatched from the SRS. Although model-generated forecast winds used in consequence assessments conducted during the incident were provided at 2-km horizontal grid spacing during the accident response, a high-resolution Regional Atmospheric Modeling System (RAMS, version 4.3.0) simulation was later performed to examine potential influences of local topography on plume migration. The detailed RAMS simulation was used to determine meteorology using multiple grids with an innermost grid spacing of 125 meters. Results from the two simulations are shown to generally agree with meteorological observations at the time; consequently, local topography did not significantly affect wind in the area. Use of a dense gas dispersion model to simulate localized plume behavior using the higher resolution

  4. Academic Training - Pulsed SC Magnets

    CERN Multimedia

    Françoise Benz

    2006-01-01

    2005-2006 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 2, 3, June 29, 30, 31 May, 1, 2 June 11:00-12:00 - Auditorium, bldg 500 Pulsed SC Magnets by M. Wilson Lecture 1. Introduction to Superconducting Materials Type 1,2 and high temperature superconductors; their critical temperature, field & current density. Persistent screening currents and the critical state model. Lecture 2. Magnetization and AC Loss How screening currents cause irreversible magnetization and hysteresis loops. Field errors caused by screening currents. Flux jumping. The general formulation of ac loss in terms of magnetization. AC losses caused by screening currents. Lecture 3. Twisted Wires and Cables Filamentary composite wires and the losses caused by coupling currents between filaments, the need for twisting. Why we need cables and how the coupling currents in cables contribute more ac loss. Field errors caused by coupling currents. Lecture 4. AC Losses in Magnets, Cooling and Measurement Summary of all loss mech...

  5. Technical Training: CERN Technical Training 2004 - New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 31.8.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 31.8.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 7.9.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and s...

  6. Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina.

    Science.gov (United States)

    Clark, Kathleen A; Karmaus, Wilfried J J; Mohr, Lawrence C; Cai, Bo; Balte, Pallavi; Gibson, James J; Ownby, Dennis; Lawson, Andrew B; Vena, John E; Svendsen, Erik R

    2016-03-01

    On January 6, 2005 a train derailment led to an estimated 54,915-kg release of chlorine at a local textile mill in Graniteville, South Carolina. We used the employee health spirometry records of the textile to identify enduring effects of chlorine gas exposure resulting from the incident on the lung function of workers employed at the textile mill. Spirometry records from 1,807 mill workers (7,332 observations) were used from 4 years before and 18 months after the disaster. Longitudinal analysis using marginal regression models produced annual population mean estimates for FEV1, FVC, and FEV1/FVC ratio. Covariate adjustment was made for sex, age, smoking, height, season tested, technician, obesity, season × year interactions, and smoker × year interactions. The increased prevalence of mill workers having accelerated FEV1 decline was also evaluated after the chlorine spill. In the year of the accident, we observed a significant reduction in mean FEV1 (-4.2% predicted; P = 0.019) when compared with the year before the incident. In the second year, partial recovery in the mean FVC % predicted level was seen, but the cohort's average FEV1/FVC ratio continued to decrease over time. Severe annual FEV1 decline was most prevalent in the year of the accident, and independent of mill worker smoking status. The Graniteville mill worker cohort revealed significant reductions in lung function immediately after the chlorine incident. Improvement was seen in the second year; but the proportion of mill workers experiencing accelerated FEV1 annual decline significantly increased in the 18 months after the chlorine incident.

  7. EngenuitySC Commercialization and Entrepreneurial Training Project

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Meghan; Hutton, Katherine R

    2012-12-31

    Holtec International for research about deployment of advanced small modular reactor (SMR) technologies. The workforce training efforts from NuHub have focused on assisting existing industry to fill positions needed to construct and operate new nuclear plants being built at the VC Summer plant in Jenkinsville, SC and at Plant Votgle in Augusta, Georgia both of whom are constructing the first nuclear reactors (Westinghouse AP 1000 units), to be built in over 30 years. This includes a partnership with Midlands Technical College to train reactor operators and the development of training facilities to support workforce development activities. It is anticipated that approximately 70 students a year will be trained through these programs in the next five years, and it will be expanded to meet new industry needs.

  8. Conversion of the dual training aircraft (DC into single control advanced training aircraft (SC. Part I

    Directory of Open Access Journals (Sweden)

    Ioan ŞTEFĂNESCU

    2011-03-01

    Full Text Available Converting the DC school jet aircraft into SC advanced training aircraft - and use them forthe combat training of military pilots from the operational units, has become a necessity due to thebudget cuts for Air Force, with direct implications on reducing the number of hours of flight assignedto operating personnel for preparing and training.The purpose of adopting such a program is to reduce the number of flight hours allocated annuallyfor preparing and training in advanced stages of instruction, for every pilot, by more intensive use ofthis type of aircraft, which has the advantage of lower flight hour costs as compared to a supersoniccombat plane.

  9. CERN Technical Training 2004: New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 22.10.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 22.10.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 9.11.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and...

  10. CERN Technical Training 2004: New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 31.8.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 31.8.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 7.9.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and she...

  11. Posttraumatic stress and tendency to panic in the aftermath of the chlorine gas disaster in Graniteville, South Carolina.

    Science.gov (United States)

    Ginsberg, Jay P; Holbrook, Joseph R; Chanda, Debjani; Bao, Haikun; Svendsen, Erik R

    2012-09-01

    Relatively little is known about psychological effects of environmental hazard disasters. This study examines the development of posttraumatic stress (PTS) and tendency to limited panic attack after a large chlorine spill in a community. In January 2005, a large chlorine spill occurred in Graniteville, SC. Acute injuries were quantified on an ordinal severity scale. Eight to ten months later, participating victims completed the Short Screening Scale for PTSD (n = 225) and the Holden Psychological Screening Inventory (HPSI) (n = 193) as part of a public health intervention. Forced expiratory volume in 1 s (FEV(1)) and forced vital capacity were likewise measured via spirometry. Two sets of univariate logistic regression models were fit to detect independent effects of each potential covariate and risk factor on PTS score and tendency to panic. A supplemental analysis examined whether poor lung function may be a confounder and/or effect modifier of the effect of acute injury on PTS score and panic. Of those who completed psychological screening, 36.9% exhibited PTS symptoms. FEV(1), acute injury, and the HPSI psychiatric subscale were independently associated with increased PTS score. Acute injury severity scale and female sex were associated with tendency to panic. Immediate acute injury severity and poor lung function later were independently associated with PTS symptomotology. The high prevalence of PTS and endorsement of tendency to panic within our sample show a need for mental health treatment after a chemical hazard disaster. Mental health personnel should be considerate of those with serious physical injuries.

  12. CERN Technical Training 2004: New Short Course III (SC III) on Microsoft Outlook - Meetings and Delegation

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled session of the 3rd module will take place as follows: Outlook (SC III): Meetings and Delegation. Next session: 9.11.2004 (14:00-16:00) SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and she will be available some time after each session to answer specific questions, or provide further explanations following demand. The cost of attending any SC module on Outlook is 70.- CHF. The above session will be confirmed if there are enough participants, and the attendance costs will be lower in case of a full class. If you are interested in...

  13. Injury Incidence and Injury Risk Factors Among U.S. Army Basic Trainees at Ft. Jackson SC, 1998 (Including Fitness Training Unit Personnel, Discharges, and Newstarts)

    National Research Council Canada - National Science Library

    Knapik, J

    1999-01-01

    An epidemiological consultation (EPICON) was requested by the Commander, U.S. Army Training Center, Ft Jackson, SC, to assist in the development of an Army Center for the Study of Training-Related Injuries. This EPICON (1...

  14. CERN Technical Training 2005: New Short Course (SC) Sessions on Office Software - July 2005

    CERN Multimedia

    Davide Vitè

    2005-01-01

    The following new course sessions are currently scheduled in the framework of the CERN Technical Training Programme 2005, within the Office Software curriculum: OUTLOOK 2003 (Short Course I) - E-mail : 6.7.2005 (morning) OUTLOOK 2003 (Short Course II) - Calendar, Tasks and Notes : 7.7.2005 (morning) OUTLOOK 2003 (Short Course III) - Meetings and Delegation : 8.7.2005 (morning) WORD 2003 (Short Course I) - HowTo... Work with repetitive tasks: 4.7.2005 (afternoon) WORD 2003 (Short Course II) - HowTo... Mail merge : 5.7.2005 (afternoon) WORD 2003 (Short Course III) - HowTo... Work with long documents : 6.7.2005 (afternoon) EXCEL 2003 (Short Course I) - HowTo... Work with formulae : 7.7.2005 (afternoon) EXCEL 2003 (Short Course II) - HowTo... Format your worksheet for printing : 8.7.2005 (afternoon) All the above sessions are organised in the new format of Short Courses (SC): 3 hour sessions (9h30-12h30 or 14h30-17h30), at a nominal cost of 75.- CHF per person per course. Any course can be followed independe...

  15. A Serious Game for Massive Training and Assessment of French Soldiers Involved in Forward Combat Casualty Care (3D-SC1): Development and Deployment.

    Science.gov (United States)

    Pasquier, Pierre; Mérat, Stéphane; Malgras, Brice; Petit, Ludovic; Queran, Xavier; Bay, Christian; Boutonnet, Mathieu; Jault, Patrick; Ausset, Sylvain; Auroy, Yves; Perez, Jean Paul; Tesnière, Antoine; Pons, François; Mignon, Alexandre

    2016-05-18

    The French Military Health Service has standardized its military prehospital care policy in a ''Sauvetage au Combat'' (SC) program (Forward Combat Casualty Care). A major part of the SC training program relies on simulations, which are challenging and costly when dealing with more than 80,000 soldiers. In 2014, the French Military Health Service decided to develop and deploy 3D-SC1, a serious game (SG) intended to train and assess soldiers managing the early steps of SC. The purpose of this paper is to describe the creation and production of 3D-SC1 and to present its deployment. A group of 10 experts and the Paris Descartes University Medical Simulation Department spin-off, Medusims, coproduced 3D-SC1. Medusims are virtual medical experiences using 3D real-time videogame technology (creation of an environment and avatars in different scenarios) designed for educational purposes (training and assessment) to simulate medical situations. These virtual situations have been created based on real cases and tested on mannequins by experts. Trainees are asked to manage specific situations according to best practices recommended by SC, and receive a score and a personalized feedback regarding their performance. The scenario simulated in the SG is an attack on a patrol of 3 soldiers with an improvised explosive device explosion as a result of which one soldier dies, one soldier is slightly stunned, and the third soldier experiences a leg amputation and other injuries. This scenario was first tested with mannequins in military simulation centers, before being transformed into a virtual 3D real-time scenario using a multi-support, multi-operating system platform, Unity. Processes of gamification and scoring were applied, with 2 levels of difficulty. A personalized debriefing was integrated at the end of the simulations. The design and production of the SG took 9 months. The deployment, performed in 3 months, has reached 84 of 96 (88%) French Army units, with a total of 818

  16. Epidemiologic methods lessons learned from environmental public health disasters: Chernobyl, the World Trade Center, Bhopal, and Graniteville, South Carolina.

    Science.gov (United States)

    Svendsen, Erik R; Runkle, Jennifer R; Dhara, Venkata Ramana; Lin, Shao; Naboka, Marina; Mousseau, Timothy A; Bennett, Charles

    2012-08-01

    Environmental public health disasters involving hazardous contaminants may have devastating effects. While much is known about their immediate devastation, far less is known about long-term impacts of these disasters. Extensive latent and chronic long-term public health effects may occur. Careful evaluation of contaminant exposures and long-term health outcomes within the constraints imposed by limited financial resources is essential. Here, we review epidemiologic methods lessons learned from conducting long-term evaluations of four environmental public health disasters involving hazardous contaminants at Chernobyl, the World Trade Center, Bhopal, and Graniteville (South Carolina, USA). We found several lessons learned which have direct implications for the on-going disaster recovery work following the Fukushima radiation disaster or for future disasters. These lessons should prove useful in understanding and mitigating latent health effects that may result from the nuclear reactor accident in Japan or future environmental public health disasters.

  17. Epidemiologic Methods Lessons Learned from Environmental Public Health Disasters: Chernobyl, the World Trade Center, Bhopal, and Graniteville, South Carolina

    Directory of Open Access Journals (Sweden)

    Timothy A. Mousseau

    2012-08-01

    Full Text Available Background: Environmental public health disasters involving hazardous contaminants may have devastating effects. While much is known about their immediate devastation, far less is known about long-term impacts of these disasters. Extensive latent and chronic long-term public health effects may occur. Careful evaluation of contaminant exposures and long-term health outcomes within the constraints imposed by limited financial resources is essential. Methods: Here, we review epidemiologic methods lessons learned from conducting long-term evaluations of four environmental public health disasters involving hazardous contaminants at Chernobyl, the World Trade Center, Bhopal, and Graniteville (South Carolina, USA. Findings: We found several lessons learned which have direct implications for the on-going disaster recovery work following the Fukushima radiation disaster or for future disasters. Interpretation: These lessons should prove useful in understanding and mitigating latent health effects that may result from the nuclear reactor accident in Japan or future environmental public health disasters.

  18. S-C Mylonites

    NARCIS (Netherlands)

    Lister, G.S.; Snoke, A.W.

    1984-01-01

    Two types of foliations are commonly developed in mylonites and mylonitic rocks: (a) S-surfaces related to the accumulation of finite strain and (b) C-surfaces related to displacement discontinuities or zones of relatively high shear strain. There are two types of S-C mylonites. Type I S-C

  19. SC tuning fork

    CERN Multimedia

    The tuning fork used to modulate the radiofrequency system of the synchro cyclotron (SC) from 1957 to 1973. This piece is an unused spare part. The SC was the 1st accelerator built at CERN. It operated from August 1957 until it was closed down at the end of 1990. In the SC the magnetic field did not change with time, and the particles were accelerated in successive pulses by a radiofrequency voltage of some 20kV which varied in frequency as they spiraled outwards towards the extraction radius. The frequency varied from 30MHz to about 17Mz in each pulse. The tuning fork vibrated at 55MHz in vacuum in an enclosure which formed a variable capacitor in the tuning circuit of the RF system, allowing the RF to vary over the appropriate range to accelerate protons from the centre of the macine up to 600Mev at extraction radius. In operation the tips of the tuning fork blade had an amplitude of movement of over 1 cm. The SC accelerator underwent extensive improvements from 1973 to 1975, including the installation of a...

  20. DiSC-OPAL

    DEFF Research Database (Denmark)

    Kemal, Mohammed Seifu; Pedersen, Rasmus; Iov, Florin

    2017-01-01

    of such systems. The simulation tool should be able to model Electrical Grid and flexible assets with different time scales and resolution levels fulfilling specific functionalities. In this paper DiSC-OPAL, an OPAL-RT compatible toolbox library for modelling of assets is presented. The library is suitable...

  1. First coil for the SC

    CERN Multimedia

    CERN PhotoLab

    1955-01-01

    The coils for the SC magnet were stored in the large hangar of the Cointrin Airport (to make sure that they would be available before snow and ice would block the roads and canals from Belgium, where they were built).

  2. Monitor of SC beam profiles

    CERN Multimedia

    CERN PhotoLab

    1977-01-01

    A high-resolution secondary emission grid for the measurement of SC beam profiles. Modern techniques of metal-ceramic bonding, developed for micro-electronics, have been used in its construction. (See Annual Report 1977 p. 105 Fig. 12.)

  3. Linking Gateway Technical College with Workforce Development: The SC Johnson-A Family Company Story.

    Science.gov (United States)

    Knudson, Edward

    2004-01-01

    Seven years ago, SC Johnson--A Family Company approached Gateway Technical College with a need to further strengthen their incumbent workforce's technical training and education. Retirements, brain drain, and competition for technical expertise were the forces driving SC Johnson to develop a comprehensive, flexible, and timely workplace education…

  4. 2010 ARRA Lidar: Bamberg County (SC)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Provide high density LiDAR elevation data map of Bamberg County, SC. Provide Bare Earth DEM (vegetation removal) of Bamberg County, SC.

  5. 2010 ARRA Lidar: Hampton County (SC)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Provide high density LiDAR elevation data map of Hampton County, SC. Provide Bare Earth DEM (vegetation removal) of Hampton County, SC.

  6. Promising prospects for 44Sc-/47Sc-based theragnostics: application of 47Sc for radionuclide tumor therapy in mice.

    Science.gov (United States)

    Müller, Cristina; Bunka, Maruta; Haller, Stephanie; Köster, Ulli; Groehn, Viola; Bernhardt, Peter; van der Meulen, Nicholas; Türler, Andreas; Schibli, Roger

    2014-10-01

    In recent years, (47)Sc has attracted attention because of its favorable decay characteristics (half-life, 3.35 d; average energy, 162 keV; Eγ, 159 keV) for therapeutic application and for SPECT imaging. The aim of the present study was to investigate the suitability of (47)Sc for radionuclide therapy in a preclinical setting. For this purpose a novel DOTA-folate conjugate (cm10) with an albumin-binding entity was used. (47)Sc was produced via the (46)Ca(n,γ)(47)Ca[Formula: see text](47)Sc nuclear reaction at the high-flux reactor at the Institut Laue-Langevin. Separation of the (47)Sc from the target material was performed by a semi-automated process using extraction chromatography and cation exchange chromatography. (47)Sc-labeled cm10 was tested on folate receptor-positive KB tumor cells in vitro. Biodistribution and SPECT imaging experiments were performed in KB tumor-bearing mice. Radionuclide therapy was conducted with two groups of mice, which received either (47)Sc-cm10 (10 MBq) or only saline. Tumor growth and survival time were compared between the two groups of mice. Irradiation of (46)Ca resulted in approximately 1.8 GBq of (47)Ca, which subsequently decayed to (47)Sc. Separation of (47)Sc from (47)Ca was obtained with 80% yield in only 10 min. The (47)Sc was then available in a small volume (∼500 μL) of an ammonium acetate/HCl (pH 4.5) solution suitable for direct radiolabeling. (47)Sc-cm10 was prepared with a radiochemical yield of more than 96% at a specific activity of up to 13 MBq/nmol. In vitro (47)Sc-cm10 showed folate receptor-specific binding and uptake into KB tumor cells. In vivo SPECT/CT images allowed the visualization of accumulated radioactivity in KB tumors and in the kidneys. The therapy study showed a significantly delayed tumor growth in mice, which received (47)Sc-cm10 (10 MBq, 10 Gy) resulting in a more than 50% increase in survival time, compared with untreated control mice. With this study, we demonstrated the suitability of

  7. Aerodynamic Characteristics of SC1095 and SC1094 R8 Airfoils

    National Research Council Canada - National Science Library

    Bousman, William G

    2003-01-01

    .... Measurements of the section lift, drag, and pitching moment have been obtained in ten wind tunnel tests for the SC1095 airfoil, and in five of these tests, measurements have also been obtained for the SC1094 R8...

  8. 46 CFR 7.70 - Folly Island, SC to Hilton Head Island, SC.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Folly Island, SC to Hilton Head Island, SC. 7.70 Section... BOUNDARY LINES Atlantic Coast § 7.70 Folly Island, SC to Hilton Head Island, SC. (a) A line drawn from the...′ W. (Port Royal Sound Lighted Whistle Buoy “2PR”); thence to the easternmost extremity of Hilton Head...

  9. Radiation Protection Section (SC/SL/RP)

    CERN Document Server

    2006-01-01

    We should like to inform you that the Radiation Protection Section (SC/SL/RP) located on the Prévessin site has moved from Building 865 (ground floor) to new premises in Wing A of Building 892 (second floor). Telephone numbers remain the same. SC/SL/RP section

  10. Sc-W-Si and Sc-W-Ge ternary systems

    International Nuclear Information System (INIS)

    Kotur, B.Ya.; Voznyak, O.M.; Bodak, O.I.

    1989-01-01

    Phase equilibria in Sc-W-Si and Sc-W-Ge ternary systems are investigated at 1070 K. Sc 2+x W 3-x Si 4 ternary compound (0≤x≤1) is determined, its crystal structure (Ce 2 Sc 3 Si 4 structural type), as well as, change of elementary cell parameters and microhardness within homogeneity range are determined. Regularities of component interaction within Sc-M-Si(Ge) (M-Cr, Mo, W) ternary system are determined. Ternary systems with Mo and W are more closer to each other according to the phase equilibria character, than to ternary systems with Cr

  11. 33 CFR 80.712 - Morris Island, SC to Hilton Head Island, SC.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Morris Island, SC to Hilton Head..., SC to Hilton Head Island, SC. (a) A line drawn from the easternmost tip of Folley Island to the... easternmost extremity of Hilton Head at latitude 32°13.0′ N. longitude 80°40.1′ W. [CGD 77-118a, 42 FR 35784...

  12. Hydrogenation studies on NdScSi and NdScGe

    Science.gov (United States)

    Tencé, Sophie; Mahon, Tadhg; Gaudin, Etienne; Chevalier, Bernard; Bobet, Jean-Louis; Flacau, Roxana; Heying, Birgit; Rodewald, Ute Ch.; Pöttgen, Rainer

    2016-10-01

    NdScSi and NdScGe were synthesized from the elements via arc-melting and subsequent annealing. Their ordered La2Sb type structures, with space group I4/mmm, were refined from single crystal X-ray diffractometer data: a=428.94(6) and b=1570.5(3) pm, wR2=0.0395, 309 F2 values for NdScSi and a=431.2(1) and c=1581.3(5) pm, wR2=0.1220, 227 F2 values for NdScGe, with 11 variables per refinement. Hydrogen insertion was performed on both Nd-based intermetallics by solid/gas reaction. Hydrogen uptake keeps the pristine compound space group but yields an anisotropic expansion of the unit cell with a large increase of c (≈+7%) and a slight decrease of a (≈-1.7%) parameters. Hydrogen absorption at 350 °C and under 5 bar of H2 pressure shows that the hydride NdScSiH1.48(5) is formed. An in-situ neutron diffraction study during the deuteration of NdScSi reveals for the first time in a CeScSi-type compound, the possibility to fill two interstitial sites with deuterium atoms, leading to the composition NdScSiD1.5 for the deuteride adopting then the La2Fe2Se2O3-type structure. From magnetization measurements, we evidence that hydrogenation strongly reduces the Curie temperature of NdScSi (TC=175 K) and NdScGe (TC=194 K) since NdScSiH1.5 and NdScGeHx undergo a magnetic transition at 4 K and around 2 K, respectively.

  13. Electron-donor-acceptor fullerene derivative retained on electrods using SC3 hydrophobin

    Czech Academy of Sciences Publication Activity Database

    Corvis, Y.; Trzcinska, K.; Rink, R.; Bílková, Petra; Gorecka, E.; Bilewicz, R.; Rogalska, E.

    2007-01-01

    Roč. 111, č. 3 (2007), s. 1176-1179 ISSN 1932-7447 Grant - others:Research Training Network(XE) HPRN-CT-2002-00171; French-Polish bilateral project Polonium(XE) 09184SC Institutional research plan: CEZ:AV0Z10100520 Keywords : fullerene * photovoltaic device * immobilization * cyclic voltammetry * electrochemistry Subject RIV: BM - Solid Matter Physics ; Magnetism

  14. 75 FR 34170 - Plastic Omnium Automotive Exteriors, LLC, Anderson, SC; Plastic Omnium Automotive Exteriors, LLC...

    Science.gov (United States)

    2010-06-16

    ... Employment and Training Administration Plastic Omnium Automotive Exteriors, LLC, Anderson, SC; Plastic Omnium... Assistance on March 18, 2010, applicable to workers of Plastic Omnium Automotive Exteriors, LLC, Anderson... have occurred involving workers in support of the Anderson, South Carolina location of Plastic Omnium...

  15. Laser photoelectron spectrometry of Sc- and Y-

    International Nuclear Information System (INIS)

    Feigerle, C.S.; Herman, Z.; Lineberger, W.C.

    1981-01-01

    The photoelectron spectra of Sc - and Y - have been obtained in a crossed ion- and laser-beam experiment. Analysis of the Sc - spectrum yields two bound terms of 3d4s 2 4p configuration ( 1 D 0 and 3 D 0 ), with EA(Sc) = 0.189 +- 0.020 eV and an excited-state binding energy of 0.042 +- 0.020 eV. Similarly, the (4d5s 2 5p) 1 D 0 ground state of Y - is bound by 0.308 +- 0.012 eV and a (4d5s 2 5p) 3 D 0 excited term is bound by 0.165 +- 0.025 eV. With the determination of the bound electronic configuration of Sc - as 3d4s 2 4p, the order of filling of electron shells of the first transition series negative ions is found to be 4s 2 ep, 3d4s 2 4p, the order of filling of electron shells of the first transition series negative ions is found to be 4s 2 4p, 3d4s 2 4p, followed by 3dsup(k) 4s 2 (k = 3, 4, ..., 10). (orig.)

  16. Final Scientific Report: DE-SC0008580

    Energy Technology Data Exchange (ETDEWEB)

    Seidler, Gerald T. [Univ. of Washington, Seattle, WA (United States)

    2017-03-16

    We report scientific, technical, and organizational accomplishments under DE-SC0008580. This includes 10 publications, 5 patent or provisional patent applications, beamtime with important results at both LCLS and APS, and new progress in understanding target design for x-ray heating experiments at x-ray heating facilities.

  17. The Synchrocyclotron (SC) in building 300

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    The red magnet of CERN's first accelerator, the Synchrocyclotron (SC), has occupied a large part of Hall 300 since it was installed in the late 1950s. The remaining part of the 300-square-metre building has been used as a storage room since the accelerator was shut down in 1990. Now a public exhibition will breathe new life into the hall.

  18. Magnet measuring equipment of SC2

    CERN Multimedia

    CERN PhotoLab

    1974-01-01

    Checking the positioning of the magnet measuring equipment installed between the poles of SC2. The steel structure in front of the magnet is designed to house the rotary condenser and to shield it from the stray magnetic field of the accelerator.

  19. Magnet measuring equipment of SC2

    CERN Multimedia

    1974-01-01

    Checking the positioning of the magnet measuring equipment installed between the poles of SC2. The steel structure in front of the magnet is designed to house the rotary condenser and to shield it from the stray magnetic field of the accelerator. On the left, Marinus van Gulik. (See Photo Archive 7402005 and Annual Report 1974, p. 44.)

  20. Knowledge insufficient: the management of haemoglobin SC disease.

    Science.gov (United States)

    Pecker, Lydia H; Schaefer, Beverly A; Luchtman-Jones, Lori

    2017-02-01

    Although haemoglobin SC (HbSC) accounts for 30% of sickle cell disease (SCD) in the United States and United Kingdom, evidence-based guidelines for genotype specific management are lacking. The unique pathology of HbSC disease is complex, characterized by erythrocyte dehydration, intracellular sickling and increased blood viscosity. The evaluation and treatment of patients with HbSC is largely inferred from studies of SCD consisting mostly of haemoglobin SS (HbSS) patients. These studies are underpowered to allow definitive conclusions about HbSC. We review the pathophysiology of HbSC disease, including known and potential differences between HbSS and HbSC, and highlight knowledge gaps in HbSC disease management. Clinical and translational research is needed to develop targeted treatments and to validate management recommendations for efficacy, safety and impact on quality of life for people with HbSC. © 2016 John Wiley & Sons Ltd.

  1. CORRELATION BETWEEN SEED TESTS AND FIELD EMERGENCE OF TWO MAIZE HYBRIDS (SC704 AND SC500)

    OpenAIRE

    A.A. ALILOO; B. SHOKATI

    2011-01-01

    Early emergence and stand establishment of maize (Zea mays L.) are considered to be the most important yield-contributing factors. The influence of seed vigor on these factors is vital. Therefore, five laboratory tests and field experiment were conducted on basis of a randomized complete block design (RCBD) with five replications in 2011, to evaluate the correlation among the seed vigor tests and field emergence of two maize hybrids (SC704 and SC500). In laboratory tests, differences between ...

  2. LHCb Data Replication During SC3

    CERN Multimedia

    Smith, A

    2006-01-01

    LHCb's participation in LCG's Service Challenge 3 involves testing the bulk data transfer infrastructure developed to allow high bandwidth distribution of data across the grid in accordance with the computing model. To enable reliable bulk replication of data, LHCb's DIRAC system has been integrated with gLite's File Transfer Service middleware component to make use of dedicated network links between LHCb computing centres. DIRAC's Data Management tools previously allowed the replication, registration and deletion of files on the grid. For SC3 supplementary functionality has been added to allow bulk replication of data (using FTS) and efficient mass registration to the LFC replica catalog.Provisional performance results have shown that the system developed can meet the expected data replication rate required by the computing model in 2007. This paper details the experience and results of integration and utilisation of DIRAC with the SC3 transfer machinery.

  3. Hemoglobin C, S-C, and E Diseases

    Science.gov (United States)

    ... quickly than others, resulting in chronic anemia. Hemoglobin C disease Hemoglobin C disease occurs mostly in blacks. ... a common complication of hemoglobin C disease. Hemoglobin S-C disease Hemoglobin S-C disease occurs in people who ...

  4. The SC gets ready for visitors

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    Hall 300, which houses the Synchrocyclotron (SC), CERN’s first accelerator, is getting ready to host a brand-new exhibition. The site will be one of the stops on the new visit itineraries that will be inaugurated for the 2013 CERN Open Day.   The Synchrocyclotron through the years. Just as it did in the late 1950s, when the accelerator was first installed, the gigantic red structure of the Synchrocyclotron's magnet occupies a large part of the 300-square-metre hall. “We have completed the first phase of the project that will give the SC a new lease of life,” says Marco Silari, the project leader and a member of CERN’s Radiation Protection Group. “We have removed all the equipment that was not an integral part of the accelerator. The hall is now ready for the civil-engineering work that will precede the installation of the exhibition.” The SC was witness to a big part of the history of CERN. The accelerator produced ...

  5. Production and separation of43Sc for radiopharmaceutical purposes.

    Science.gov (United States)

    Domnanich, Katharina A; Eichler, Robert; Müller, Cristina; Jordi, Sara; Yakusheva, Vera; Braccini, Saverio; Behe, Martin; Schibli, Roger; Türler, Andreas; van der Meulen, Nicholas P

    2017-01-01

    The favorable decay properties of 43 Sc and 44 Sc for PET make them promising candidates for future applications in nuclear medicine. An advantage 43 Sc (T 1/2 = 3.89 h, Eβ + av = 476 keV [88%]) exhibits over 44 Sc, however, is the absence of co-emitted high energy γ-rays. While the production and application of 44 Sc has been comprehensively discussed, research concerning 43 Sc is still in its infancy. This study aimed at developing two different production routes for 43 Sc, based on proton irradiation of enriched 46 Ti and 43 Ca target material. 43 Sc was produced via the 46 Ti(p,α) 43 Sc and 43 Ca(p,n) 43 Sc nuclear reactions, yielding activities of up to 225 MBq and 480 MBq, respectively. 43 Sc was chemically separated from enriched metallic 46 Ti (97.0%) and 43 CaCO 3 (57.9%) targets, using extraction chromatography. In both cases, ~90% of the final activity was eluted in a small volume of 700 μL, thereby, making it suitable for direct radiolabeling. The prepared products were of high radionuclidic purity, i.e. 98.2% 43 Sc were achieved from the irradiation of 46 Ti, whereas the product isolated from irradiated 43 Ca consisted of 66.2% 43 Sc and 33.3% 44 Sc. A PET phantom study performed with 43 Sc, via both nuclear reactions, revealed slightly improved resolution over 44 Sc. In order to assess the chemical purity of the separated 43 Sc, radiolabeling experiments were performed with DOTANOC, attaining specific activities of 5-8 MBq/nmol, respectively, with a radiochemical yield of >96%. It was determined that higher 43 Sc activities were accessible via the 43 Ca production route, with a comparatively less complex target preparation and separation procedure. The product isolated from irradiated 46 Ti, however, revealed purer 43 Sc with minor radionuclidic impurities. Based on the results obtained herein, the 43 Ca route features some advantages (such as higher yields and direct usage of the purchased target material) over the 46 Ti path when aiming at 43 Sc

  6. Preliminary Analysis of the Social and Scientific Impact of the UAEM-ININ M.Sc. and D.Sc. Graduate Programme in Medical Physics

    Science.gov (United States)

    Mitsoura, Eleni; Isaac-Olive, Keila; Torres-Garcia, Eugenio; Camacho-Lopez, Miguel Angel; Hardy-Perez, Alberto

    2010-12-01

    Sponsored by the International Atomic Energy Agency (IAEA) in 1994, the Instituto Nacional de Investigaciones Nucleares (ININ) started in Mexico a teaching and training programme (Diplomado) in Radiotherapy Medical Physics. Based on this experience, the Universidad Autónoma del Estado de México (UAEM) and the Instituto Nacional de Investigaciones Nucleares (ININ) launched two years later, the first Graduate Programme in Science (M.Sc. and D.Sc.), specialised in Medical Physics in Mexico. A preliminary analysis of the social and scientific impact of the UAEM-ININ Programme is presented in this work based on the achievements attained, regarding the number of graduated Medical Physicists, their geographic and academic origin, their current professional activities and the number of scientific publications produced as a result of the thesis, as well as their citations.

  7. Final Scientific Report: DE-SC0002194

    Energy Technology Data Exchange (ETDEWEB)

    Seidler, Gerald [Univ. of Washington, Seattle, WA (United States)

    2017-04-07

    We provide the final scientific report for DE-SC0002194. During the term of this grant, 28 publications spanning a variety of topics were addressed under the rubric of advanced x-ray methods and their application to extreme conditions of time-resolution or x-ray intensities. Notable accomplishments include a new observation of XANES features associated with f-shell reconfiguration in lanthanides, size-dependent x-ray heating effects under XFEL illumination conditions, theoretical development of improved treatments of inelastic x-ray scattering for 'warm dense matter' conditions, and several new instrument develop efforts for atomic, molecular, and condensed phase studies in the lab and at major facility lightsources.

  8. SC2: Secure Communication over Smart Cards

    DEFF Research Database (Denmark)

    Dragoni, Nicola; Lostal, Eduardo; Papini, Davide

    2012-01-01

    The Security-by-Contract (S×C) framework has recently been proposed to support software evolution in open multi-application smart cards. The key idea lies in the notion of contract, a specification of the security behavior of an application that must be compliant with the security policy...... of the card hosting the application. In this paper we address a key issue to realize the S×C idea, namely the outsourcing of the contractpolicy matching service to a Trusted Third Party (TTP). In particular, we present the design and implementation of (SC)2 (Secure Communication over Smart Cards), a system...... securing the communication between a smart card and the TTP which provides the S×C matching service....

  9. The SC State NSF PAARE Program

    Science.gov (United States)

    Walter, Donald; Ajello, Marco; Brittain, Sean; Cash, Jennifer; Fogle, Bryan; Hartmann, Dieter; Ho, Shirley; Howell, Steve; King, Jeremy; Leising, Mark; Smith, Daniel

    2018-01-01

    We report on the activities of our NSF PAARE program during Year 3 of the project. Our partnership under this award includes South Carolina State University (a Historically Black College/University), Clemson University (a Ph.D. granting institution) and individual investigators at NASA Ames and elsewhere. Our partnership with the Citizen CATE Experiment and involvement in the total solar eclipse which passed through our campus on August 21, 2017, will be discussed. The PAARE project continues to strengthen our partnership with Clemson. We are close to completing a memorandum of agreement between the two institutions that will allow for the seamless transfer of an undergraduate from SC State to Clemson’s graduate program in physics and astronomy. Additionally, we have worked together under the Citizen CATE project and through other research activities. SC State is a member of the National Astronomy Consortium (NAC) and participates through its faculty and undergraduates, one of whom (Wesley Red) is reporting on his summer internship at this conference. We also served as the state coordinator for South Carolina for the Citizen CATE Experiment. The August 21st path of totality crossed through our campus and the campus of our partner Clemson University. Additional colleges, universities and citizen scientist groups partnered with us to provide 7 sites of coverage across South Carolina from the foothills of the Appalachian mountains to the Atlantic Ocean near the site of departure of the shadow from the continental U.S. Support for this work includes our NSF PAARE award AST-1358913 as well as resources and support provided by Clemson University and the National Optical Astronomy Observatory. CATE work has been supported by NASA SMD award NNX16AB92A to the National Solar Observatory. Additional details can be found at: http://physics.scsu.edu

  10. Energy Levels, wavelengths and hyperfine structure measurements of Sc II

    Science.gov (United States)

    Hala, Fnu; Nave, Gillian

    2018-01-01

    Lines of singly ionized Scandium (Sc II) along with other Iron group elements have been observed [1] in the region surrounding the massive star Eta Carinae [2,3] called the strontium filament (SrF). The last extensive analysis of Sc II was the four-decade old work of Johansson & Litzen [4], using low-resolution grating spectroscopy. To update and extend the Sc II spectra, we have made observation of Sc/Ar, Sc/Ne and Sc/Ge/Ar hollow cathode emission spectrum on the NIST high resolution FT700 UV/Vis and 2 m UV/Vis/IR Fourier transform spectrometers (FTS). More than 850 Sc II lines have been measured in the wavelength range of 187 nm to 3.2 μm. connecting a total of 152 energy levels. The present work also focuses to resolve hyperfine structure (HFS) in Sc II lines. We aim to obtain accurate transition wavelengths, improved energy levels and HFS constants of Sc II. The latest results from work in progress will be presented.Reference[1] Hartman H, Gull T, Johansson S and Smith N 2004 Astron. Astrophys. 419 215[2] Smith N, Morse J A and Gull T R 2004 Astrophys. J. 605 405[3] Davidson K and Humphreys R M 1997 Annu. Rev. Astron. Astrophys. 35[4] Johansson S and Litzén U 1980 Phys. Scr. 22 49

  11. Cyclotron production of 43Sc for PET imaging

    OpenAIRE

    Walczak, Rafa?; Krajewski, Seweryn; Szkliniarz, Katarzyna; Sitarz, Mateusz; Abbas, Kamel; Choi?ski, Jaros?aw; Jakubowski, Andrzej; Jastrz?bski, Jerzy; Majkowska, Agnieszka; Simonelli, Federica; Stolarz, Anna; Trzci?ska, Agnieszka; Zipper, Wiktor; Bilewicz, Aleksander

    2015-01-01

    Background Recently, significant interest in 44Sc as a tracer for positron emission tomography (PET) imaging has been observed. Unfortunately, the co-emission by 44Sc of high-energy ? rays (E ??=?1157, 1499?keV) causes a dangerous increase of the radiation dose to the patients and clinical staff. However, it is possible to produce another radionuclide of scandium?43Sc?having properties similar to 44Sc but is characterized by much lower energy of the concurrent gamma emissions. This work prese...

  12. The Resilient Schools Consortium (RiSC): Linking Climate Literacy, Resilience Thinking and Service Learning

    Science.gov (United States)

    Branco, B. F.; Fano, E.; Adams, J.; Shon, L.; Zimmermann, A.; Sioux, H.; Gillis, A.

    2017-12-01

    Public schools and youth voices are largely absent from climate resilience planning and projects in New York City. Additionally, research shows that U.S. science teachers' understanding of climate science is lacking, hence there is not only an urgent need to train and support teachers on both the science and pedagogy of climate change, but to link climate literacy, resilience thinking and service learning in K-12 education. However, research on participation of students and teachers in authentic, civic-oriented experiences points to increased engagement and learning outcomes in science. The Resilient Schools Consortium (RiSC) Project will address all these needs through an afterschool program in six coastal Brooklyn schools that engages teachers and urban youth (grades 6-12), in school and community climate resilience assessment and project design. The RiSC climate curriculum, co-designed by New York City school teachers with Brooklyn College, the National Wildlife Federation, New York Sea Grant and the Science and Resilience Institute at Jamaica Bay, will begin by helping students to understand the difference between climate and weather. The curriculum makes extensive use of existing resources such as NOAA's Digital Coast and the Coastal Resilience Mapping Portal. Through a series of four modules over two school years, the six RiSC teams will; 1. explore and understand the human-induced drivers of climate change and, particularly, the significant climate and extreme weather related risks to their schools and surrounding communities; 2. complete a climate vulnerability assessment within the school and the community that is aligned to OneNYC - the city's resilience planning document; 3. design and execute a school-based resilience project; and 4. propose resilience guidelines for NYC Department of Education schools. At the end of each school year, the six RiSC teams will convene a RiSC summit with city officials and resilience practitioners to share ideas and

  13. Cyclotron production of {sup 44}Sc for clinical application

    Energy Technology Data Exchange (ETDEWEB)

    Krajewski, S.; Bilewicz, A. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cydzik, I. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection; Warsaw Univ. (Poland). Heavy Ion Lab.; Abbas, K. [European Commission Joint Research Center, Ispra (Italy). Institute for Transuranium Elements; Bulgheroni, A.; Simonelli, F.; Holzwarth, U. [European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection

    2013-08-01

    {sup 44} is a promising {beta}{sup +}-emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc{sup 3+} to the Lu{sup 3+} and Y{sup 3+} cations, {sup 44}Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the {sup 177}Lu- and {sup 90}Y-bioconjugates, what is important in planning the radionuclide therapy. {sup 44}Sc can be obtained from the {sup 44}Ti/{sup 44}Sc generator. An alternative method for {sup 44}Sc production can be the irradiation of {sup 44}Ca target at small cyclotrons. The aim of our work was to optimize the parameters of {sup 44}CaCO{sub 3} irradiation and to develop a simple procedure for {sup 44}Sc separation from the calcium target. For optimization study, {sup 44}CaCO{sub 3} targets were irradiated by protons in the energy range of 5.6-17.5 MeV with 9 MeV being found to be the best energy for {sup 44}Ca irradiations. A simple and fast separation procedure of {sup 44}Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced {sup 44}Sc. While {sup 44}CaCO{sub 3} is relatively expensive, the cost of {sup 44}Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of {sup 44}Sc, the availability of {sup 44}Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging. (orig.)

  14. Cyclotron production of (43)Sc for PET imaging.

    Science.gov (United States)

    Walczak, Rafał; Krajewski, Seweryn; Szkliniarz, Katarzyna; Sitarz, Mateusz; Abbas, Kamel; Choiński, Jarosław; Jakubowski, Andrzej; Jastrzębski, Jerzy; Majkowska, Agnieszka; Simonelli, Federica; Stolarz, Anna; Trzcińska, Agnieszka; Zipper, Wiktor; Bilewicz, Aleksander

    2015-12-01

    Recently, significant interest in (44)Sc as a tracer for positron emission tomography (PET) imaging has been observed. Unfortunately, the co-emission by (44)Sc of high-energy γ rays (E γ = 1157, 1499 keV) causes a dangerous increase of the radiation dose to the patients and clinical staff. However, it is possible to produce another radionuclide of scandium-(43)Sc-having properties similar to (44)Sc but is characterized by much lower energy of the concurrent gamma emissions. This work presents the production route of (43)Sc by α irradiation of natural calcium, its separation and purification processes, and the labeling of [DOTA,Tyr3] octreotate (DOTATATE) bioconjugate. Natural CaCO3 and enriched [(40)Ca]CaCO3 were irradiated with alpha particles for 1 h in an energy range of 14.8-30 MeV at a beam current of 0.5 or 0.25 μA. In order to find the optimum method for the separation of (43)Sc from irradiated calcium targets, three processes previously developed for (44)Sc were tested. Radiolabeling experiments were performed with DOTATATE radiobioconjugate, and the stability of the obtained (43)Sc-DOTATATE was tested in human serum. Studies of (nat)CaCO3 target irradiation by alpha particles show that the optimum alpha particle energies are in the range of 24-27 MeV, giving 102 MBq/μA/h of (43)Sc radioactivity which creates the opportunity to produce several GBq of (43)Sc. The separation experiments performed indicate that, as with (44)Sc, due to the simplicity of the operations and because of the chemical purity of the (43)Sc obtained, the best separation process is when UTEVA resin is used. The DOTATATE conjugate was labeled by the obtained (43)Sc with a yield >98 % at elevated temperature. Tens of GBq activities of (43)Sc of high radionuclidic purity can be obtainable for clinical applications by irradiation of natural calcium with an alpha beam.

  15. Hydride vapor phase epitaxy growth of GaN, InGaN, ScN, and ScAIN

    NARCIS (Netherlands)

    Bohnen, T.

    2010-01-01

    Chemical vapor deposition (CVD); hydride vapor phase epitaxy (HVPE); gallium nitride (GaN); indium gallium nitride (InGaN); scandium nitride (ScN); scandium aluminum nitride (ScAlN); semiconductors; thin films; nanowires; III nitrides; crystal growth - We studied the HVPE growth of different III

  16. Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv

    NARCIS (Netherlands)

    Arafat, WO; Gomez-Navarro, J; Buchsbaum, DJ; Xiang, J; Casado, E; Barker, SD; Mahasreshti, PJ; Haisma, HJ; Barnes, MN; Siegal, GP; Alvarez, RD; Hemminki, A; Nettelbeck, DM; Curiel, DT

    Single chain antibodies (scFv) represent powerful interventional agents for the achievement of targeted therapeutics. The practical utility of these agents have been limited, however, by difficulties related to production of recombinant scFv and the achievement of effective and sustained levels of

  17. IEC SC15E: Report on liaison activities of CIGRÉ-SC15

    DEFF Research Database (Denmark)

    Henriksen, Mogens

    2000-01-01

    WG’s activities under CIGRÉ SC15:WG 15.01 - Fluid impregnated systems.WG 15.02 - Dielectric Liquids.WG 15.03 - Gas Insulation.WG 15.04 - Outdoor Insulation.WG 15.05 - Capacitors.WG 15.07 - Solid Insulating Materials for Rotating Machines.WG 15/33.08 - Insulation Monitoring and Life Estimation. WG...... 15.09 - Advanced Materials.WG 15.10 - Internal Insulation and Interfaces.WG 15.11 - Service-Aged Materials.WG 15.12 - DC Insulation/Space Charge Measurements....

  18. Structural Behavior of SC and RC Panels under Impact Loading

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyuk-Kee; Kim, Seung-Eock [Sejong University, Seoul (Korea, Republic of)

    2015-05-15

    NPP structures have been generally constructed using reinforced concrete (RC) structures. In recent studies, however, it has been confirmed that a steel-plate concrete (SC) structures has a much better impact resistance than an RC structure. In this paper, the impact resistance of SC and RC panels is evaluated using the commercial software LS-DYNA. To verify finite element (FE) models, the analysis results for SC and half steel-plate concrete panels under impact loading are compared with the test results conducted in other research. The impact analysis according to the different steel ratios with four different concrete thicknesses is performed in order to compare the impact resistance of SC and RC panels. To compare the impact resistance of SC and RC panels, the impact analysis was performed according to the different steel ratios with four different concrete thicknesses. Based on this study, the following conclusions have been obtained: (1) The rear face steel plate of SC panel plays more important role than the rear rebar of RC panel in preventing perforation. (2) When the perforation failure occurs, RC panel is more effective than SC panel to reduce the velocity of the missile.

  19. Ultimate internal pressure capacity assessment of SC structure

    International Nuclear Information System (INIS)

    Park, Hyungkui; Choi, Inkil

    2013-01-01

    An SC structure applied to a containment building can be quite effective. However, an SC structure cannot be applied to a containment building, because its internal pressure resistance performance has not been verified. The containment building, which undergoes ultimate internal pressure, resists the internal pressure through a pre-stress tendon. It is hard to apply a tendon to an SC structure because of its structural characteristics. Therefore, the internal pressure resistance performance of the SC structure itself should be ensured to apply it to a structure with internal pressure resistance. In this study, the suitability of an SC structure as a substitution for the tendon of a pressure resistant structure was evaluated. A containment structure model was used in this study, because it was representative structures that resistance of ultimate internal pressure be required. In this study, a nonlinear analysis was performed to evaluate and compare the behaviors of tendon model and SC structure model. By comparing the internal pressure-displacement according to the structure type, the stability of SC structure model was assessed

  20. Pascal-SC a computer language for scientific computation

    CERN Document Server

    Bohlender, Gerd; von Gudenberg, Jürgen Wolff; Rheinboldt, Werner; Siewiorek, Daniel

    1987-01-01

    Perspectives in Computing, Vol. 17: Pascal-SC: A Computer Language for Scientific Computation focuses on the application of Pascal-SC, a programming language developed as an extension of standard Pascal, in scientific computation. The publication first elaborates on the introduction to Pascal-SC, a review of standard Pascal, and real floating-point arithmetic. Discussions focus on optimal scalar product, standard functions, real expressions, program structure, simple extensions, real floating-point arithmetic, vector and matrix arithmetic, and dynamic arrays. The text then examines functions a

  1. Precipitation in cold-rolled Al-Sc-Zr and Al-Mn-Sc-Zr alloys prepared by powder metallurgy

    KAUST Repository

    Vlach, Martin

    2013-12-01

    The effects of cold-rolling on thermal, mechanical and electrical properties, microstructure and recrystallization behaviour of the AlScZr and AlMnScZr alloys prepared by powder metallurgy were studied. The powder was produced by atomising in argon with 1% oxygen and then consolidated by hot extrusion at 350 C. The electrical resistometry and microhardness together with differential scanning calorimetry measurements were compared with microstructure development observed by transmission and scanning electron microscopy, X-ray diffraction and electron backscatter diffraction. Fine (sub)grain structure developed and fine coherent Al3Sc and/or Al3(Sc,Zr) particles precipitated during extrusion at 350 C in the alloys studied. Additional precipitation of the Al3Sc and/or Al3(Sc,Zr) particles and/or their coarsening was slightly facilitated by the previous cold rolling. The presence of Sc,Zr-containing particles has a significant antirecrystallization effect that prevents recrystallization at temperatures minimally up to 420 C. The precipitation of the Al6Mn- and/or Al 6(Mn,Fe) particles of a size ~ 1.0 μm at subgrain boundaries has also an essential antirecrystallization effect and totally suppresses recrystallization during 32 h long annealing at 550 C. The texture development of the alloys seems to be affected by high solid solution strengthening by Mn. The precipitation of the Mn-containing alloy is highly enhanced by a cold rolling. The apparent activation energy of the Al3Sc particles formation and/or coarsening and that of the Al6Mn and/or Al 6(Mn,Fe) particle precipitation in the powder and in the compacted alloys were determined. The cold deformation has no effect on the apparent activation energy values of the Al3Sc-phase and the Al 6Mn-phase precipitation. © 2013 Elsevier Inc.

  2. Design of SC walls and slabs for impulsive loading

    Energy Technology Data Exchange (ETDEWEB)

    Varma, Amit H. [Purdue Univ., West Lafayette, IN (United States)

    2015-11-11

    Reinforced concrete (RC) structures have historically been the preferred choice for blast resistant structures because of their mass and the ductility provided by steel reinforcement. Steel-plate composite (SC) walls are a viable alternative to RC for protecting the infrastructure against explosive threats. SC structures consist of two steel faceplates with a plain concrete core between them. The steel faceplates are anchored to the concrete using stud anchors and connected to each other using tie bars. SC structures provide mass from the concrete infill and ductility from the continuous external steel faceplates. This dissertation presents findings and recommendations from experimental and analytical investigations of the performance of SC walls subjected to far-field blast loads.

  3. scFv Antibody: Principles and Clinical Application

    Directory of Open Access Journals (Sweden)

    Zuhaida Asra Ahmad

    2012-01-01

    Full Text Available To date, generation of single-chain fragment variable (scFv has become an established technique used to produce a completely functional antigen-binding fragment in bacterial systems. The advances in antibody engineering have now facilitated a more efficient and generally applicable method to produce Fv fragments. Basically, scFv antibodies produced from phage display can be genetically fused to the marker proteins, such as fluorescent proteins or alkaline phosphatase. These bifunctional proteins having both antigen-binding capacity and marker activity can be obtained from transformed bacteria and used for one-step immunodetection of biological agents. Alternatively, antibody fragments could also be applied in the construction of immunotoxins, therapeutic gene delivery, and anticancer intrabodies for therapeutic purposes. This paper provides an overview of the current studies on the principle, generation, and application of scFv. The potential of scFv in breast cancer research is also discussed in this paper.

  4. scFv antibody: principles and clinical application.

    Science.gov (United States)

    Ahmad, Zuhaida Asra; Yeap, Swee Keong; Ali, Abdul Manaf; Ho, Wan Yong; Alitheen, Noorjahan Banu Mohamed; Hamid, Muhajir

    2012-01-01

    To date, generation of single-chain fragment variable (scFv) has become an established technique used to produce a completely functional antigen-binding fragment in bacterial systems. The advances in antibody engineering have now facilitated a more efficient and generally applicable method to produce Fv fragments. Basically, scFv antibodies produced from phage display can be genetically fused to the marker proteins, such as fluorescent proteins or alkaline phosphatase. These bifunctional proteins having both antigen-binding capacity and marker activity can be obtained from transformed bacteria and used for one-step immunodetection of biological agents. Alternatively, antibody fragments could also be applied in the construction of immunotoxins, therapeutic gene delivery, and anticancer intrabodies for therapeutic purposes. This paper provides an overview of the current studies on the principle, generation, and application of scFv. The potential of scFv in breast cancer research is also discussed in this paper.

  5. The data acquisition system (DAS) for the improved CERN SC

    CERN Document Server

    Beger, H; Fiebig, A; Schroot, H

    1975-01-01

    A digital data acquisition system (DAS) based on a minicomputer is described which registers the failure sequences in various equipment areas of the CERN synchrocyclotron (henceforward referred to as the SC). The avalanches of failure signals which occur from time to time are tapped from the alarm/security systems, time-resolved to 10 msec and recorded on a printer in order to aid SC failure diagnosis. The mechanisms of the DAS and its relation to the SC equipment are explained in some detail. All programs were constructed at assembler language level for speed and for ease of on-line program maintenance. The alarm sequences recorded have been of considerable help during the running in of the new radiofrequency system. Now that the new SC is operational, the DAS furnishes useful data from several equipment areas to the operators and engineers.

  6. Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First ...

    African Journals Online (AJOL)

    Tahir M. Malla

    2015-07-14

    /licenses/by-nc-nd/4.0/). 1. Introduction. Roberts SC phocomelia syndrome is an autosomal recessive developmental disorder characterized by pre and postnatal growth retardation, microcephaly, craniofacial anomalies,.

  7. Lifetime and g-factor measurements in 44Sc

    International Nuclear Information System (INIS)

    Chevallier, A.; Chavallier, J.; Gross, J.L.; Haas, B.; Schulz, N.; Styczen, J.; Toulemonde, M.

    1975-01-01

    The lifetimes of the 235 keV, 2 - state and 350 keV, 4 + state in 44 Sc have been measured via the 44 Ca(p, n) 44 Sc reaction with a pulsed proton beam. The time integral perturbed angular distribution technique with an external field was used to measure the precession angles of the 2 - and 4 + states populated by the 30 Si( 16 O, pnγ) 44 Sc reaction. The following values for the mean-lives and g-factors were obtained: π(2 - ) = 8.83(33) ns, g(2 - ) = 0.30(13) and π(4 + ) = 4.52(27)ns, g(4 + ) = 0.90(12). The results for the 2 - state support a rotational description of the negative parity states in 44 Sc. The magnetic moment of the 4 + state is compared to shell model predictions. (orig.) [de

  8. Development of SC structure modularization in Nuclear Power Plant

    International Nuclear Information System (INIS)

    Mun, Taeyoup

    2008-01-01

    New Focus on NPP are Rising Concerns on Global Warming, Potential energy crisis (geo-political), Improved reliability and safety of nuclear power plant, Advent of Generation 3+ NPP technology and Economical Energy Resource. New NPPs are 6 units in Korea and 23 in Asia being built, 32 units being planned in China by 2020 (150 by 2050), 10 units being planned in US by 2020 and IAEA expects $200 billions on NPP construction next 25 years (up to 30% of total world energy). □ SC(Steel Plate Concrete) structure · Steel Plate is used as a Structural Element instead of Reinforcing Bars in RC · SC structure consists of Steel Plate with Headed Studs. Connected by Tie-bars - The Primary Purpose of Tie-bars is to Stiffen and Hold Together the Plates during Construction Process - Headed Studs are Welded to the Inside of Steel Plate for composite action □ Benefits of SC Structure · Shorten Construction Duration for Re bar, Forming and Scaffolding Works · Minimize Site Labors · Improve the Construction Quality · Enable Construction Sites to be kept Clean □ SC Modularization · Fit for Modular Construction for Structural Features · Fit for Modular Construction for Structural Features · Inattentively Effective for Integrated Modules · Pre-fabrication, Pre-assembly and Modularization □ Project Overview · Project Name: Development of SC structure for Modularization in NPP · Project Type: Electric Power Industry R and D (Ministry of Knowledge Economy) · Duration: Sep. 2005 ∼ Aug. 2008 (36 Months) · Research Team and Scopes - Project Management: Korea Hydro and Nuclear Power Company (KHNP) - Development of Code and Standards for SC Structure: Korea Society of Steel Construction (KSSC) Korea Electric Power Research Institute (KEPRI) - Development of SC Structural Analysis and Design: Korea Power Engineering Company (KOPEC) - Development of Construction Techniques for SC Modularization: KHNP, Korea Institute of Nuclear Safety(KINS), KOPEC □ Performance

  9. scFv Antibody: Principles and Clinical Application

    OpenAIRE

    Ahmad, Zuhaida Asra; Yeap, Swee Keong; Ali, Abdul Manaf; Ho, Wan Yong; Alitheen, Noorjahan Banu Mohamed; Hamid, Muhajir

    2012-01-01

    To date, generation of single-chain fragment variable (scFv) has become an established technique used to produce a completely functional antigen-binding fragment in bacterial systems. The advances in antibody engineering have now facilitated a more efficient and generally applicable method to produce Fv fragments. Basically, scFv antibodies produced from phage display can be genetically fused to the marker proteins, such as fluorescent proteins or alkaline phosphatase. These bifunctional prot...

  10. Electrochemical Characterization of Ni/(Sc)YSZ Electrodes

    DEFF Research Database (Denmark)

    Ramos, Tania; Thydén, Karl Tor Sune; Mogensen, Mogens Bjerg

    2010-01-01

    Investigations of Ni/(Sc)YSZ cermets for solid oxide cells (SOCs) were performed by electrochemical impedance spectroscopy (EIS), under varying experimental conditions and upon redox cycling, using three different designs of symmetric cells. The deconvolution and fitting of the obtained impedance...... parameters. Initial degradation results for both Ni/ScYSZ and Ni/YSZ based anodes under very high steam content are also reported. ©2010 COPYRIGHT ECS - The Electrochemical Society...

  11. Interfacial properties and characterization of Sc/Si multilayers

    Energy Technology Data Exchange (ETDEWEB)

    Shendruk, T.N., E-mail: tshen098@uottawa.c [Department of Physics and Engineering Physics, University of Saskatchewan, 116 Science Place, Saskatoon, SK, S7N 5E2 (Canada); Moewes, A. [Department of Physics and Engineering Physics, University of Saskatchewan, 116 Science Place, Saskatoon, SK, S7N 5E2 (Canada); Kurmaev, E.Z. [Institute of Metal Physics, Russian Academy of Sciences-Ural Division, 620041 Yekaterinburg (Russian Federation); Ochin, P. [ICMPE Institut de Chimie et Materiaux Paris Est, CNRS-Universite Paris XII UMR 7182, 2-8 rue Henri Dunant F-94320 Thiais (France); Maury, H.; Andre, J.-M.; Le Guen, K.; Jonnard, P. [Laboratoire de Chimie Physique-Matiere et Rayonnement, UPMC Univ Paris 06, 11 rue Pierre et Marie Curie, F-75231 Paris Cedex 05 (France); CNRS-UMR 7614, 11 rue Pierre et Marie Curie, F-75231 Paris Cedex 05 (France)

    2010-05-03

    We investigate the intermixing of layers in Sc/Si and Sc/B{sub 4}C/Si/B{sub 4}C multilayers using electron and synchrotron excited soft X-ray emission and absorption spectroscopy. The multilayers are annealed at 100, 200, 300, 400 and 500 {sup o}C after preparation by magnetron sputtering. Silicon K{sub {beta}} emission and reflectivity measurements verify that the non-annealed multilayer systems are composed of distinct layers with only a minor interdiffusion in Sc/Si samples whereas annealing Sc/Si multilayers at 400 {sup o}C leads to a degradation of the multilayer structure and the formation of intermittent scandium silicide, ScSi. The presence of B{sub 4}C barriers in Sc/B{sub 4}C/Si/B{sub 4}C hinders this degradation from developing for the entire temperature range considered. The barrier layers continue to be effective for the entire temperature range even after an extended shelf-life.

  12. Heteronuclear transition metal diatomics - The bonding and electronic structure of ScNi, YNi, ScPd, and YPd

    Science.gov (United States)

    Faegri, Knut, Jr.; Bauschlicher, Charles W., Jr.

    1991-01-01

    High quality ab initio calculations show that ScNi, YNi, ScPd, and YPd all have 2Sigma(+) ground states in agreement with electron spin resonance experiments. For ScNi and YNi, this is expected based on the lowest atomic asymptote. For ScPd and YPd, the lowest atomic asymptote would give the order of stability 2Delta greater than 2Pi equal to about 2Sigma(+), but the calculations show that mixing in of the excited asymptotes preferentially lowers the 2Sigma(+) state. The calculations show that the quartet states are about 20-30 kcal/mol above the ground state, and therefore probably do not contribute significantly to the unexpected g(vertical) values found in experiment. Calculations of excited states for YPd reveal some strong transitions that should be amenable to spectroscopic studies.

  13. Compensation of native donor doping in ScN: Carrier concentration control and p-type ScN

    Science.gov (United States)

    Saha, Bivas; Garbrecht, Magnus; Perez-Taborda, Jaime A.; Fawey, Mohammed H.; Koh, Yee Rui; Shakouri, Ali; Martin-Gonzalez, Marisol; Hultman, Lars; Sands, Timothy D.

    2017-06-01

    Scandium nitride (ScN) is an emerging indirect bandgap rocksalt semiconductor that has attracted significant attention in recent years for its potential applications in thermoelectric energy conversion devices, as a semiconducting component in epitaxial metal/semiconductor superlattices and as a substrate material for high quality GaN growth. Due to the presence of oxygen impurities and native defects such as nitrogen vacancies, sputter-deposited ScN thin-films are highly degenerate n-type semiconductors with carrier concentrations in the (1-6) × 1020 cm-3 range. In this letter, we show that magnesium nitride (MgxNy) acts as an efficient hole dopant in ScN and reduces the n-type carrier concentration, turning ScN into a p-type semiconductor at high doping levels. Employing a combination of high-resolution X-ray diffraction, transmission electron microscopy, and room temperature optical and temperature dependent electrical measurements, we demonstrate that p-type Sc1-xMgxN thin-film alloys (a) are substitutional solid solutions without MgxNy precipitation, phase segregation, or secondary phase formation within the studied compositional region, (b) exhibit a maximum hole-concentration of 2.2 × 1020 cm-3 and a hole mobility of 21 cm2/Vs, (c) do not show any defect states inside the direct gap of ScN, thus retaining their basic electronic structure, and (d) exhibit alloy scattering dominating hole conduction at high temperatures. These results demonstrate MgxNy doped p-type ScN and compare well with our previous reports on p-type ScN with manganese nitride (MnxNy) doping.

  14. Multidisciplinary Training on Spiritual Care for Patients in Palliative Care Trajectories Improves the Attitudes and Competencies of Hospital Medical Staff: Results of a Quasi-Experimental Study.

    Science.gov (United States)

    van de Geer, Joep; Veeger, Nic; Groot, Marieke; Zock, Hetty; Leget, Carlo; Prins, Jelle; Vissers, Kris

    2018-02-01

    Patients value health-care professionals' attention to their spiritual needs. However, this is undervalued in health-care professionals' education. Additional training is essential for implementation of a national multidisciplinary guideline on spiritual care (SC) in palliative care (PC). Aim of this study is to measure effects of a training program on SC in PC based on the guideline. A pragmatic multicenter trial using a quasi-experimental pretest-posttest design as part of an action research study. Eight multidisciplinary teams in regular wards and 1 team of PC consultants, in 8 Dutch teaching hospitals, received questionnaires before training about perceived barriers for SC, spiritual attitudes and involvement, and SC competencies. The effect on the barriers on SC and SC competencies were measured both 1 and 6 months after the training. For nurses (n = 214), 7 of 8 barriers to SC were decreased after 1 month, but only 2 were still after 6 months. For physicians (n = 41), the training had no effect on the barriers to SC. Nurses improved in 4 of 6 competencies after both 1 and 6 months. Physicians improved in 3 of 6 competencies after 1 month but in only 1 competency after 6 months. Concise SC training programs for clinical teams can effect quality of care, by improving hospital staff competencies and decreasing the barriers they perceive. Differences in the effects of the SC training on nurses and physicians show the need for further research on physicians' educational needs on SC.

  15. Technology in S&C: Assessing Bodyweight Squat Technique with Wearable Sensors.

    Science.gov (United States)

    O'Reilly, Martin A; Whelan, Darragh F; Ward, Tomas E; Delahunt, Eamonn; Caulfield, Brian M

    2017-04-15

    Strength and conditioning (S&C) coaches offer expert guidance to help those they work with achieve their personal fitness goals. However it is not always practical to operate under the direct supervision of an S&C coach and consequently individuals are often left training without expert oversight. Recent developments in inertial measurement units (IMUs) and mobile computing platforms have allowed for the possibility of unobtrusive motion tracking systems and the provision of real-time individualised feedback regarding exercise performance. These systems could enable S&C coaches to remotely monitor sessions and help individuals record their workout performance. One aspect of such technologies is the ability to assess exercise technique and detect common deviations from acceptable exercise form. In this study we investigate this ability in the context of a bodyweight (BW) squat exercise. IMUs were positioned on the lumbar spine, thighs and shanks of 77 healthy participants. Participants completed repetitions of BW squats with acceptable form and five common deviations from acceptable BW squatting technique. Descriptive features were extracted from the IMU signals for each BW squat repetition and these were used to train a technique classifier. Acceptable or aberrant BW squat technique can be detected with 98% accuracy, 96% sensitivity and 99% specificity when using features derived from all 5 IMUs. A single IMU system can also distinguish between acceptable and aberrant BW squat biomechanics with excellent accuracy, sensitivity and specificity. Detecting exact deviations from acceptable BW squatting technique can be achieved with 80% accuracy using a 5 IMU system and 72% accuracy when using a single IMU positioned on the right shank. These results suggest IMU based systems can distinguish between acceptable and aberrant BW squat technique with excellent accuracy with a single IMU system. Identification of exact deviations is also possible but multi-IMU systems

  16. Final Technical Report for Award SC0008613

    Energy Technology Data Exchange (ETDEWEB)

    Knopf, Daniel A. [Stony Brook Univ., NY (United States)

    2017-04-05

    Discovering how aerosol particles, present in the atmosphere in sizes of a few nanometers to hundred micrometers, initiate ice crystal formation represents a great challenge. Atmospheric ice nucleation is important because ice crystals alter the radiative properties of clouds and thus climate, and impact precipitation and thus the hydrological cycle. The difficulty in predicting atmospheric ice formation is attributable at least in part, to the diversity of ice nucleation pathways, the physical and chemical complexity of the ice nucleating particles (INPs), and the relatively small numbers of INPs (compared with all other aerosol particles), sometimes less than one in 100000. These factors in turn makes constraining ice nucleation parameterizations for modeling applications challenging. The majority of airborne particles are known to be organic in nature or contain organic biogenic material. The presence of organic material adds to the complexity of the particles and therefore the predictability of ice nucleation events since the organic species can display different phase states, e.g. liquid or solid, in response to temperature and humidity. The award DE-SC0008613 to PI Prof. Daniel Knopf at Stony Brook University, “Relating the Chemical and Physical Properties of Aerosols to the Water Uptake and Ice Nucleation Potential of Particles Collected During the Carbonaceous Aerosols and Radiative Effects Study (CARES)”, allowed examination of laboratory generated aerosol particles and field-collected particles for their propensity to nucleate ice under typical tropospheric conditions and relate ice nucleation to the physicochemical properties of the particles including their morphology and chemical composition. This in turn allowed for development of ice nucleation parameterizations for implementation in cloud models. The award resulted in 10 peer-reviewed publications and more than 20 seminar and conference presentations. We demonstrated that the rate of immersion

  17. The ternary systems Sc-Sm(Dy)-Si at 870 K

    International Nuclear Information System (INIS)

    Kotur, B.Ya.; Mokra, I.Ya.; Toporinskij, A.Ya.

    1991-01-01

    Isothermal cross sections of the ternary systems Sc-Sm-Si and Sc-Dy-Si at 870 K have been plotted. Investigation of scandium and disprosium in ternary systems have been examined by X-ray diffraction and microstructure analysis. Besides literary data on binary systems Sc-Si, Sm-Si, Dy-Si have been used. Formation of limited (Sc-Sm-Si, Sc-Dy-Si) and continuous (Sc-Dy-Si) solid solutions based on bisilicides of Sc and Sm(Dy) is discovered. Two and five ternary compounds in Sc-Sm-Si and Sc-Dy-Si systems have been determined and their crystal structure has been established. When investigating of Sc-(rare earth element)-Si ternary systems and should take into account the specific interaction of scandium and samarium with REE

  18. Transport of one SC coil through the village of Meyrin

    CERN Multimedia

    1956-01-01

    In 1952, before CERN was officially founded, two accelerator projects were launched: one for an innovative accelerator to operate at an energy level unequalled at the time, the other for a more standard machine, a Synchro-Cyclotron (SC) to operate at 600 MeV. Design work on the SC was started in 1952 and carried out by teams scattered throughout Europe. Once construction began in 1954, CERN had to arrange road transport for the first of what has since been a long series of spectacular component deliveries, such as those of the machine's two magnetic coils each weighing 60 tonnes and measuring 7.2 metres in diameter. Above, one of them is seen passing through the village of Meyrin. The SC was commissioned in 1957 and was operational for 34 years!

  19. Experimental Progress of DC-SC Photoinjector at Peking University

    CERN Document Server

    Wang, G M; Ding, Y T; Hao, J; Huang, S L; Lin, L; Lu, X Y; Quan, S W; Wang, L F; Xiang, R; Zhang, B C; Zhao, K; Jiao, F; Xie, D; Yang, L; Zhu, F; Liu, C; Wang, F; Xu, W; Liu, Z

    2005-01-01

    Beam loading experiments on DC-SC photoinjector test facility have been finished at 4.4 K. Upon the present experiments, the gradient of 6 MV/m is achieved. The maximum energy gain is 1.1 MeV at 4.4 K. With average beam current of 270 mA, the measured rms emittance is about 5 mm-mrad at the beam energy of 500 keV. Experiments on the test facility has validated that the DC-SC photoinjector is a good choice to provide moderate average current electron beams with low bunch charge and very high repetition rate.

  20. Thermoelectric performance of functionalized Sc2C MXenes

    KAUST Repository

    Kumar, S.

    2016-07-05

    Functionalization of the MXene Sc2C, which has the rare property to realize semiconducting states for various functionalizations including O, F, and OH, is studied with respect to the electronic and thermal behavior. The lowest lattice thermal conductivity is obtained for OH functionalization and an additional 30% decrease can be achieved by confining the phonon mean free path to 100 nm. Despite a relatively low Seebeck coefficient, Sc2C(OH)2 is a candidate for intermediate-temperature thermoelectric applications due to compensation by a high electrical conductivity and very low lattice thermal conductivity.

  1. Calculations on the stress compensated (SC-cut) quartz resonator

    International Nuclear Information System (INIS)

    EerNisse, E.P.

    1976-01-01

    Theoretical calculations have been carried out on the doubly-rotated SC-cut quartz resonator. The resonant frequency of this resonator is free from the third-order elastic constant effects of static mechanical stress bias. Calculations show that this stress compensation can be adjusted independently from the temperature compensation during fabrication. Angular tolerances necessary to attain the stress compensation are investigated. The theoretical results are shown to agree quantitatively with recently published thermal shock measurements. Gneral expressions for the SC-cut and AT-cut are provided to allow simple calculation of the frequency shifts due to any static mechanical stress bias

  2. Radiation protection Group (SC/RP) desperately seeking...

    CERN Multimedia

    A. Hervé, Y. Donjoux / SC

    2006-01-01

    We are trying to trace two transit permits (passavants), which constitute the customs clearance documentation for two 'AD6'portable radiation detectors. The two permits (No. 1308 and No. 1309) were sent in the same internal mail envelope towards the middle of March 2006 but never reached their final destination. After weeks of searching in vain, we are now appealing for your help. If you have these two permits in your possession, please get in touch with us. Many thanks in advance. A.HERVE - SC/RP- ( 163168 / 70927) Y.DONJOUX - SC/RP - (160105 / 73171)

  3. Bayesian narrowband interference mitigation in SC-FDMA

    KAUST Repository

    Ali, Anum

    2015-08-12

    This paper presents a novel narrowband interference (NBI) mitigation scheme for SC-FDMA systems. The proposed scheme exploits the frequency domain sparsity of the unknown NBI signal and adopts a low complexity Bayesian sparse recovery procedure. In practice, however, the sparsity of the NBI is destroyed by a grid mismatch between NBI sources and SC-FDMA system. Towards this end, an accurate grid mismatch model is presented and a sparsifying transform is utilized to restore the sparsity of the unknown signal. Numerical results are presented that depict the suitability of the proposed scheme for NBI mitigation.

  4. Low-β SC linacs: past, present, and future

    International Nuclear Information System (INIS)

    Bollinger, L. M.

    1998-01-01

    This paper is a general review of superconducting low-β technology and applications from its beginning in 1969 into the near-term future. The emphasis is on studies of accelerating resonators and on SC linacs that boost the energy of heavy-ion beams from tandem electrostatic accelerators used for nuclear-physics research. Other topics are positive-ion SC injectors to replace tandems and the need for accelerating structures with β outside of the present proven range, 0.008 < β < 0.2

  5. Ab-initio studies of the Sc adsorption and the ScN thin film formation on the GaN(000-1)-(2 × 2) surface

    International Nuclear Information System (INIS)

    Guerrero-Sánchez, J.; Sánchez-Ochoa, F.; Cocoletzi, Gregorio H.; Rivas-Silva, J.F.; Takeuchi, Noboru

    2013-01-01

    First principles total energy calculations have been performed to investigate the initial stages of the Sc adsorption and ScN thin film formation on the GaN(000-1)-(2 × 2) surface. Studies are done within the periodic density functional theory as implemented in the PWscf code of the Quantum ESPRESSO package. The Sc adsorption at high symmetry sites results in the bridge site as the most stable structure. When a Sc monolayer is deposited above the surface the T4 site results as the most stable geometry. The Sc migration into the first Ga monolayer induces the Ga displaced ad-atom to be adsorbed at the T4-2 site. A ScN bilayer may be obtained under the Ga monolayer. Finally a ScN bilayer may be formed in the wurtzite phase above the surface. The formation energy plots show that in the moderate Ga-rich conditions we obtain the formation of a ScN bilayer under the gallium monolayer. However at N-rich conditions the formation of ScN bilayer above the surface is the most favorable structure. We report the density of states to explain the electronic structure of the most favorable geometries. - Highlights: • Studies of the initial stages in the formation of Sc and ScN structures on GaN • In the adsorption of Sc on the GaN the Br site is the most favorable geometry. • When a Sc replaces a Ga of the first monolayer the displaced Ga occupies a T4-2 site. • For Ga-rich conditions there is formation of ScN under the Ga monolayer. • In N-rich conditions there is formation of ScN in the wurtzite phase

  6. Determining volume sensitive waters in Beaufort County, SC tidal creeks

    Science.gov (United States)

    Andrew Tweel; Denise Sanger; Anne Blair; John Leffler

    2016-01-01

    Non-point source pollution from stormwater runoff associated with large-scale land use changes threatens the integrity of ecologically and economically valuable estuarine ecosystems. Beaufort County, SC implemented volume-based stormwater regulations on the rationale that if volume discharge is controlled, contaminant loading will also be controlled.

  7. Toelating Herbasan SC welkom voor dahlia, A. coronaria en narcis

    NARCIS (Netherlands)

    Leeuwen, van P.J.; Koster, A.T.J.; Trompert, J.P.T.

    2005-01-01

    Onlangs is Herbasan SC voor de onkruidbestrijding in onder meer dahlia, narcis en Anemone coronaria toegelaten. PPO ging na hoe het middel het beste is in te zetten. In dit artikel zijn de resultaten van het onderzoek vermeld en een advies voor toepassing

  8. Initiation of flux jump in SC composite by heat pulse

    International Nuclear Information System (INIS)

    Klimenko, E.Y.; Martovetaky, N.N.

    1989-01-01

    Nonisothermal diffusion of magnetic flux after heat pulse shot on the surface of SC composite has been studied numerically taking into account smoothed transition characteristic of the superconductor. It is shown that for SC composite with poor stabilization the current and heat redistribution changes significantly the estimations of stability used on steady state functions of heat generation and heat transfer. The critical pulsed energy strongly depends on initial current distribution over the conductor cross section and the energy may be much less for a conductor with growing current than for a conductor with the same current in steady state. It has been found that undercritical heat pulses only slightly affect current density profile but stability increases as time delay increases between the current input halt and the pulse shot. It has been found that for a SC composite with poor stabilization the transversal thermal conductivity is more important than electrical resistivity of the matrix from the stability standpoint. The critical energy decreases when the thickness of SC filaments increases and this may explain unstable behaviour of the wires with thick filaments

  9. Annual evapotranspiration of a forested wetland watershed, SC

    Science.gov (United States)

    Devendra M. Amatya; Carl Trettin

    2007-01-01

    In this study, hydro-meteorological data collected from 1 964 to 1 9 76 on an approximately 5, 000 ha predominantly forested coastal watershed (Turkey Creek) at the Francis Marion National Forest near Charleston, SC were analyzed to estimate annual evapotranspiration (E T) using four different empirical methods. The first one, reported by Zhang et a/. (2001), that...

  10. 44gSc from metal calcium targets for PET

    DEFF Research Database (Denmark)

    Severin, Gregory; Gagnon, K.; Engle, J. W.

    2012-01-01

    A low-cost and efficient method for producing pre-clinical scale quantities of 44gSc is presented. Production involves proton irradiation of natural unenriched calcium metal followed by rapid separation of radioscandium from the target using hydroxmate functionalized resin.© 2012 American Institu...

  11. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    This catalogue contains a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd...... semester projects at the M.Sc. programme in Civil and Structural Engineering....

  12. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    Clausen, Johan

    The report contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...... projects at the M.Sc. programme in Civil and Structural Engineering....

  13. Isolates of Mycoplasma mycoides subspecies mycoides (SC) in ...

    African Journals Online (AJOL)

    A study on the isolation of Mycoplasma mycoides subspecies mycoides (SC) in small ruminants and its implication on disease control was carried out in the Sahel zone of Nigeria. This was achieved by the examination of pneumonic lesions in apparently normal and affected lungs of sheep and goats slaughtered at ...

  14. 78 FR 20369 - South Carolina Disaster #SC-00021

    Science.gov (United States)

    2013-04-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION South Carolina Disaster SC-00021 AGENCY: U.S. Small Business Administration. ACTION: Notice... dated 03/29/2013. Incident: Windsor Green Condo Complex Fire. Incident Period: 03/16/2013. Effective...

  15. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    The catalogue contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...... projects at the M.Sc. programme in Civil and Structural Engineering....

  16. Construct Validation of the Sc Scale of the MMPI.

    Science.gov (United States)

    Keane, Susan Phillips; Gibbs, Margaret

    1980-01-01

    Tested the hypothesis that subjects with elevated MMPI profiles would exhibit qualitatively different word associations from those with normal MMPI profiles. Results are interpreted as demonstrating the construct validity of the Sc scale in that the more pathological the profile, the greater degree of cognitive disturbance exhibited. (Author)

  17. Structural, elastic and thermodynamic properties of Ti2SC

    Indian Academy of Sciences (India)

    Administrator

    Abstract. The structural parameters, elastic constants and thermodynamic properties of Ti2SC were investi- gated under pressure and temperature by using first-principles plane-wave pseudopotential density functional theory within the generalized gradient approximation. The obtained results are in agreement with the.

  18. Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First ...

    African Journals Online (AJOL)

    Tahir M. Malla

    2015-07-14

    Jul 14, 2015 ... Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir. Tahir M. Malla, Arshad A. Pandith, Fayaz A. Dar, Mahrukh H. Zargar *. Advanced Centre for Human Genetics, Sher-i-Kashmir Institute of Medical Sciences, Srinagar 190011, India. Received 5 June 2015; accepted 18 ...

  19. Gleaning data from disaster: a hospital-based data mining method to study all-hazard triage after a chemical disaster.

    Science.gov (United States)

    Craig, Jean B; Culley, Joan M; Tavakoli, Abbas S; Svendsen, Erik R

    2013-01-01

    To describe the methods of evaluating currently available triage models for their efficacy in appropriately triaging the surge of patients after an all-hazards disaster. A method was developed for evaluating currently available triage models using extracted data from medical records of the victims from the Graniteville chlorine disaster. On January 6, 2005, a freight train carrying three tanker cars of liquid chlorine was inadvertently switched onto an industrial spur in central Graniteville, SC. The train then crashed into a parked locomotive and derailed. This caused one of the chlorine tankers to rupture and immediately release ~60 tons of chlorine. Chlorine gas infiltrated the town with a population of 7,000. This research focuses on the victims who received emergency care in South Carolina. With our data mapping and decision tree logic, the authors were successful in using the available extracted clinical data to estimate triage categories for use in our study. The methodology outlined in this article shows the potential use of well-designed secondary analysis methods to improve mass casualty research. The steps are reliable and repeatable and can easily be extended or applied to other disaster datasets.

  20. Update on the NSF PAARE Program at SC State

    Science.gov (United States)

    Walter, Donald K.; Ajello, Marco; Brittain, Sean D.; Cash, Jennifer; Hartmann, Dieter; Ho, Shirley; Howell, Steve B.; King, Jeremy R.; Leising, Mark D.; Smith, Daniel M.

    2017-01-01

    We report on results from our NSF PAARE program during Year 2 of the project. Our partnership under this PAARE award includes South Carolina State University (a Historically Black College/University), Clemson University (a Ph.D. granting institution) as well as individual investigators at NASA Ames and Carnegie Mellon University. Our recent work on variable and peculiar stars, work with the Kepler Observatory and our educational products in cosmology for non-STEM majors will be presented. We have successfully piloted sharing our teaching resources by offering an upper-level astrophysics course taught at Clemson via video conferencing , allowing a graduating senior from SC State to take a course not available through his home institution. Additionally, we are working on a memorandum of agreement between the two institutions that will allow for the seamless transfer of an undergraduate from SC State to Clemson’s graduate program in physics and astronomy. Our curriculum work includes new web-based cosmology activities and laboratory experiments. SC State undergraduates are reporting at this conference on their work with the light curves of semiregular variables using Kepler data. Additionally, we are heavily involved in the Citizen CATE Experiment. A PAARE scholarship student from SC State and the PAARE PI traveled to Indonesia for the March 2016 solar eclipse. Their results are also being presented elsewhere at this conference (see Myles McKay’s poster). Support for this work includes our NSF PAARE award AST-1358913 as well as resources and support provided by Clemson University and the National Optical Astronomy Observatory. Additional support has been provided by the South Carolina Space Grant Consortium and from NASA to SC State under awards NNX11AB82G and NNX13AC24G. CATE work has been supported by NASA SMD award NNX16AB92A to the National Solar Observatory. Additional details can be found at: http://physics.scsu.edu

  1. Two anionically derivatized scandium oxoselenates(IV): ScF[SeO3] and Sc2O2[SeO3

    Science.gov (United States)

    Greiner, Stefan; Chou, Sheng-Chun; Schleid, Thomas

    2017-02-01

    Scandium fluoride oxoselenate(IV) ScF[SeO3] and scandium oxide oxoselenate(IV) Sc2O2[SeO3] could be synthesized through solid-state reactions. ScF[SeO3] was obtained phase-pure, by reacting mixtures of Sc2O3, ScF3 and SeO2 (molar ratio: 1:1:3) together with CsBr as fluxing agent in corundum crucibles embedded into evacuated glassy silica ampoules after firing at 700 °C for seven days. Sc2O2[SeO3] first emerged as by-product during the attempts to synthesize ScCl[SeO3] following aforementioned synthesis route and could later be reproduced from appropriate Sc2O3/SeO3 mixtures. ScF[SeO3] crystallizes monoclinically in space group P21/m with a=406.43(2), b =661.09(4), c=632.35(4) pm, β=93.298(3)° and Z=2. Sc2O2[SeO3] also crystallizes in the monoclinic system, but in space group P21/n with a=786.02(6), b=527.98(4), c=1086.11(8) pm, β=108.672(3)° for Z=4. The crystal structures of both compounds are strongly influenced by the stereochemically active lone pairs of the ψ1-tetrahedral [SeO3]2- anions. They also show partial structures, where the derivatizing F- or O2- anions play an important role. For ScF[SeO3] chains of the composition 2+∞ 1[FS c 2 / 2 ] form from connected [FSc2]5+ dumbbells, while [OSc3]7+ pyramids and [OSc4]10+ tetrahedra units are condensed to layers according to 2+ ∞ 2[O2Sc2 ] in Sc2O2[SeO3].

  2. Topotactic oxidation pathway of ScTiO3 and high-temperature structure evolution of ScTiO3.5 and Sc4Ti3O12-type phases.

    Science.gov (United States)

    Shafi, Shahid P; Hernden, Bradley C; Cranswick, Lachlan M D; Hansen, Thomas C; Bieringer, Mario

    2012-02-06

    The novel oxide defect fluorite phase ScTiO(3.5) is formed during the topotactic oxidation of ScTiO(3) bixbyite. We report the oxidation pathway of ScTiO(3) and structure evolution of ScTiO(3.5), Sc(4)Ti(3)O(12), and related scandium-deficient phases as well as high-temperature phase transitions between room temperature and 1300 °Cusing in-situ X-ray diffraction. We provide the first detailed powder neutron diffraction study for ScTiO(3). ScTiO(3) crystallizes in the cubic bixbyite structure in space group Ia3 (206) with a = 9.7099(4) Å. The topotactic oxidation product ScTiO(3.5) crystallizes in an oxide defect fluorite structure in space group Fm3m (225) with a = 4.89199(5) Å. Thermogravimetric and differential thermal analysis experiments combined with in-situ X-ray powder diffraction studies illustrate a complex sequence of a topotactic oxidation pathway, phase segregation, and ion ordering at high temperatures. The optimized bulk synthesis for phase pure ScTiO(3.5) is presented. In contrast to the vanadium-based defect fluorite phases AVO(3.5+x) (A = Sc, In) the novel titanium analogue ScTiO(3.5) is stable over a wide temperature range. Above 950 °C ScTiO(3.5) undergoes decomposition with the final products being Sc(4)Ti(3)O(12) and TiO(2). Simultaneous Rietveld refinements against powder X-ray and neutron diffraction data showed that Sc(4)Ti(3)O(12) also exists in the defect fluorite structure in space group Fm3m (225) with a = 4.90077(4) Å. Sc(4)Ti(3)O(12) undergoes partial reduction in CO/Ar atmosphere to form Sc(4)Ti(3)O(11.69(2)).

  3. Luminescence Properties of ScPO{sub 4} Single Crystals

    Energy Technology Data Exchange (ETDEWEB)

    Boatner, L.A.; Trukhin, A.N.

    1999-08-16

    Flux-grown ScPO{sub 4} single crystals exhibit a number of luminescence bands in their x-ray-excited luminescence spectra - including sharp lines arising from rare-earth elements plus a number of broad bands at 5.6 cV, 4.4 eV, and 3 eV. The band at 5.6 eV was attributed to a self-trapped exciton (STE) [l], and it could be excited at 7 eV and higher energies. This luminescence is strongly polarized (P = 70 %) along the optical axes of the crystal and exhibits a kinetic decay time constant that varies from several ns at room temperature to {approximately}10 {micro}s at 60 K and up to {approximately}1 ms at 10 K. It is assumed that the STE is localized on the SC ions. The band at 3 eV can be excited in the range of the ScPO{sub 4} crystal transparency (decay time = 3 to 4 {micro}s.) This band is attributed to a lead impurity that creates different luminescence centers. At high temperatures, the band at 4.4 eV is dominant in the x-ray-excited TSL and afterglow spectra. Its intensity increases with irradiation time beginning at zero at the initial irradiation time. The 4.4 eV band does not appear in a fast process under a pulsed electron beam, showing that accumulation is necessary for its observation. A sample of ScPO{sub 4} doped with vanadium exhibited a prevalent band at 4.4 eV at T = 480 K.

  4. SC-HTGR Performance Impact for Arid Sites

    International Nuclear Information System (INIS)

    Lommers, L.; Geschwindt, J.; Southworth, F.; Shahrokhi, F.

    2014-01-01

    The SC-HTGR provides high temperature steam which can support industrial process heat applications as well as high efficiency electricity generation. The increased generating efficiency resulting from using high steam temperature provides greater plant output than lower temperature concepts, and it also reduces the fraction of waste heat which must be rejected. This capability is particularly attractive for sites with little or no water for heat rejection. This high temperature capability provides greater flexibility for these sites, and it results in a smaller performance penalty than for lower temperature systems when dry cooling must be used. The performance of the SC-HTGR for a conventional site with wet cooling is discussed first. Then the performance for arid sites is evaluated. Dry cooling performance is evaluated for both moderately arid sites and very hot sites. Offdesign performance of the dry cooling system under extreme conditions is also considered. Finally, operating strategies are explored for sites where some cooling water may be available but only in very limited quantities. Results of these assessments confirm that the higher operating temperatures of the SC-HTGR are very beneficial for arid sites, providing significant advantages for both gross and net power generation. (author)

  5. QUALITY MANAGEMENT OF BAKERY PRODUCTS: A CASE STUDY IN SC

    Directory of Open Access Journals (Sweden)

    Nicoleta- Luminiţa STRÂMBEANU RISTEA

    2013-01-01

    Full Text Available The paper aimed to present the benefits of implementing HACCP (Hazard Analysis and Critical Control Points to company S.C. "DOBRE AND SONS" S.R.L. Constanta, Romania. The data have been provided by the above mentioned manufacturer. The objectives of S.C. "DOBRE AND SONS" S.R.L. are protecting the health of the consumers of the products and their satisfaction regarding the consumption of products that are nutritional, tasty, fresh, free from microbiological, chemical and physical hazard, as well as possessing stable properties during the validity for consumption. In this respect, there has been implemented and maintained an integrated management system of food quality and safety according to SR EN ISO 9001:2008, SR EN ISO 22000:2005 and according to IFS standard, version 5/2007, which consists of determining the potential biological, chemical and physical hazards that might affect the safety of bread and bakery products, or the health of the consumer. HACCP team is analyzing hazard using one of the recommended techniques: brainstorming or the cause - effect diagram. In conclusion, the company S.C. "DOBRE AND SONS" S.R.L. Constanta, Romania provides awareness and employee involvement at all levels in achieving the appointed objectives.

  6. 77 FR 51475 - Safety Zone; Apache Pier Labor Day Fireworks; Myrtle Beach, SC

    Science.gov (United States)

    2012-08-24

    ... Beach, SC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is... Myrtle Beach, SC, during the Labor Day fireworks demonstration. This regulation is necessary to protect life and property on the navigable waters of the Atlantic Ocean off the coast of Myrtle Beach, SC...

  7. Crystal fields of dilute Tb, Dy, or Er in Sc obtained by magnetization measurements

    DEFF Research Database (Denmark)

    Høg, J.; Touborg, P.

    1976-01-01

    Crystal-field parameters for dilute Sc-Tb, Sc-Dy, and Sc-Er alloys have been obtained by fitting theoretical expressions to the experimentally measured paramagnetic susceptibility. The initial susceptibility was measured and corrected for the effects of ordering at the lowest temperatures...

  8. Differential dynamics of splicing factor SC35 during the cell cycle

    Indian Academy of Sciences (India)

    Srinivas

    We analysed the dynamics of the splicing factor SC35 in interphase and mitotic cells. In HeLa cells expressing green fluorescent protein (GFP)-SC35, this was localized ... Cell cycle dynamics; FRAP analysis; mitotic interchromatin granules; splicing factor SC35 .... for 1 h at room temperature for single labelling experiments.

  9. Differential dynamics of splicing factor SC35 during the cell cycle

    Indian Academy of Sciences (India)

    We analysed the dynamics of the splicing factor SC35 in interphase and mitotic cells. In HeLa cells expressing green fluorescent protein (GFP)-SC35, this was localized in speckles during interphase and dispersed in metaphase. In telophase, GFP-SC35 was highly enriched within telophase nuclei and also detected in ...

  10. Level densities and γ strength functions in light Sc and Ti isotopes

    International Nuclear Information System (INIS)

    Burger, A.; Larsen, A.C.; Syed, N.U.H.; Guttormsen, M.; Nyhus, H.; Siem, S.; Harissopulos, S.; Konstantinopoulos, T.; Lagoyannis, A.; Perdidakis, G.; Spyrou, A.; Kmiecik, M.; Mazurek, K.; Krticka, M.; Loennroth, T.; Norby, M.; Voinov, A.

    2010-01-01

    We present preliminary results from a measurement of nuclear level densities and the γ-ray strength of light Sc (Sc 43 , Sc 45 ) and Ti (Ti 44 , Ti 45 and Ti 46 ) isotopes using the Oslo Method. The article begins with a presentation of the experimental setup. (authors)

  11. Cost and Training Effectiveness Analysis (CTEA) of the CH-47 Flight Simulator (CH47FS).

    Science.gov (United States)

    1976-12-03

    DACA -CAZ) USAI SC (ATTSC) (DUSA-OR) - (ATTSC-TD) (DAND-ODA) (ATTSC-TP) ( DACA -CAM ) (ATTSC-IT) CINGUSAREUR (AIACC-T) (ArrsC-CT) (ATFE-LOAE) (ATrSC-LO... necessity . b. A tra ining guide for unit flying train ing must be developed that will be followed by- the experimental subject aviators par ticipating

  12. Performance Analysis of OFDM 60GHz System and SC-FDE 60GHz System

    Directory of Open Access Journals (Sweden)

    Han Xueyan

    2016-01-01

    Full Text Available In this paper, the performance of 60GHz wireless communication system with SC and OFDM is studied, the models of OFDM 60GHz system and SC 60GHz frequency domain equalization (SC-FDE system are established, and the bit error rate (BER performance of OFDM 60GHz system and SC-FDE 60GHz system in 802.15.3c channels is compared. The simulation results show that SC-FDE 60GHz system has a slight advantage over OFDM system in line-of-sight (LOS channels, while OFDM 60GHz system has a slight advantage over SC-FDE system in non-line-of-sight (NLOS channels. For 60GHz system, OFDM 60GHz system has a slight advantage over SC-FDE system in overcoming multipath fading, but the performance of both is close whether in the LOS or NLOS case.

  13. LOCAL COLLISION SIMULATION OF AN SC WALL USING ENERGY ABSORBING STEEL

    Directory of Open Access Journals (Sweden)

    CHUL-HUN CHUNG

    2013-08-01

    Full Text Available This study evaluates the local damage of a turbine in an auxiliary building of a nuclear power plant due to an external impact by using the LS-DYNA finite element program. The wall of the auxiliary building is SC structure and the material of the SC wall plate is high manganese steel, which has superior ductility and energy absorbance compared to the ordinary steel used for other SC wall plates. The effects of the material of the wall, collision speed, and angle on the magnitude of the local damage were evaluated by local collision analysis. The analysis revealed that the SC wall made of manganese steel had significantly less damage than the SC wall made of ordinary steel. In conclusion, an SC wall made of manganese steel can have higher effective resistance than an SC wall made of ordinary steel against the local collision of an airplane engine or against a turbine impact.

  14. INCREASING OF THE EXPRESSION OF RECOMBINANT scFv-ANTIBODIES EFFICIENCY

    Directory of Open Access Journals (Sweden)

    O.V. Galkin

    2017-10-01

    Full Text Available Obtaining single-chain variable fragments (scFv of recombinant antibodies in E. coli cells is often associated with numerous problems causing low yields or inactive conformation of the product. The aim of this work was to study the influence of staphylococcal protein A fragment fused with scFv antibodies (SpA-tag on the efficiency of expression of final product. Examination of scFv antibodies of different origin and specificity has shown that in similar expression systems fused scFv is synthesized in much higher quantities than free scFv. Furthermore, the scFv antibodies in fused form retained their antigen-binding properties and the SpA fragment the ability to bind other immunoglobulins. Thus, the proposed strategy can be considered effective in improving the efficiency of scFv-antibodies production in E. coli cells.

  15. Observing environmental European legislation - strategic priority of SC Termoelectrica

    International Nuclear Information System (INIS)

    Pop, Ovidiu; Motiu, Cornel

    2004-01-01

    Defined as the main Romanian power producer, SC Termoelectrica is also a Company that faced over 50 years of experience and confrontations with different technical, economical and legislative problems. The measures of restructuring that were taken during the last years, also included a program of retiring of use of some inefficient and in excess units. That brought our company at its actual structure that consists in producing, repairs and services units, organized as commercial societies and subsidiaries of SC Termoelectrica. The activity of producing thermal and electric power using old power equipment (33.84% of them are over 30 years old, 46.54% are between 10-20 years old and only 0.64 % are under 10 years old) and without control pollution installations or having inefficient installations, led to the increasing of some environmental problems along the years. The paper has the following structure: - Introduction; - Actual situation; - The accession to the European Union - the control of industrial pollution (The abatement of atmospheric, water and soil pollution); - The mitigation of greenhouse gases. In conclusion one stresses that no matter which will be the way of organization the environmental approach at European or national level, these will become a strategic priority for SC Termoelectrica. The way these environmental problems will be solved will have a great influence on: - The company's thermal power plants work, while their impact upon the local, regional and global environment will be almost nonexistent; - The offer of electric power produced by thermal power plants in national and international transactions; - The fulfillment of the three objectives of a power producer: accessibility, availability and acceptability

  16. Molecular and cellular pathogenesis of hemoglobin SC disease.

    OpenAIRE

    Bunn, H F; Noguchi, C T; Hofrichter, J; Schechter, G P; Schechter, A N; Eaton, W A

    1982-01-01

    Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb) SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated mixtures containing sickle cell Hb (Hb S; alpha 2 beta 2(6)Glu leads to Val) and Hb C (alpha 2 beta 2(6)Glu leads to Lys) was investigated by measurements of delay times and solubilities. In mixtures containing more than 40% Hb S, polymerization takes place by the same mechanism as in solutions of Hb S alone, with no evi...

  17. PET imaging of 64Cu-DOTA-scFv-anti-PSMA lipid nanoparticles (LNPs): Enhanced tumor targeting over anti-PSMA scFv or untargeted LNPs

    International Nuclear Information System (INIS)

    Wong, Patty; Li, Lin; Chea, Junie; Delgado, Melissa K.; Crow, Desiree; Poku, Erasmus; Szpikowska, Barbara; Bowles, Nicole; Channappa, Divya; Colcher, David; Wong, Jeffrey Y.C.; Shively, John E.; Yazaki, Paul J.

    2017-01-01

    Introduction: Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance. Methods: An anti-prostate membrane antigen (PSMA) scFv with a site-specific cysteine was expressed and evaluated in a prostate cancer xenograft model by Cu-64 PET imaging. To enhance tumor accumulation, the scFv-cys was conjugated to the co-polymer DSPE-PEG-maleimide that spontaneously assembled into a homogeneous multivalent lipid nanoparticle (LNP). Results: The targeted LNP exhibited a 2-fold increase in tumor uptake compared to the scFv alone using two different thiol ester chemistries. The anti-PSMA scFv-LNP exhibited a 1.6 fold increase in tumor targeting over the untargeted LNP. Conclusions: The targeted anti-PSMA scFv-LNP showed enhanced tumor accumulation over the scFv alone or the untargeted DOTA-micelle providing evidence for the development of this system for drug delivery. Advances in knowledge and implications for patient care: Anti-tumor scFv antibody fragments have not achieved their therapeutic potential due to their fast blood clearance. Conjugation to an LNP enables multivalency to the tumor antigen as well as increased molecular size for chemotherapy drug delivery.

  18. Negative thermal expansion in Sc2(WO4)3

    International Nuclear Information System (INIS)

    Evans, J.S.O.; Mary, T.A.; Sleight, A.W.

    1998-01-01

    Sc 2 (WO 4 ) 3 has been found to show the highly unusual property of negative thermal expansion over a temperature range of 10 to 1,073 K. Powder neutron diffraction data from 10 to 450 K shows an essentially linear decrease in cell volume as a function of temperature. The intrinsic linear coefficient of thermal expansion from this data is -2.2 x 10 -6 K -1 . The linear coefficient of thermal expansion measured on a ceramic bar of Sc 2 (WO 4 ) 3 can be as negative as -11 x 10 -6 K -1 due to microstructure changes as a function of temperature. Rietveld refinement as a function of temperature suggests that the intrinsic negative thermal expansion can be related to transverse vibrations of bridging oxygen atoms in the structure. The anharmonic nature of these vibrations leads to a coupled tilting of the quasi-rigid framework polyhedra. This tilting in turn causes the structure to become more dense with increasing temperature

  19. Predeployment training for forward medicalisation in a combat zone: the specific policy of the French Military Health Service.

    Science.gov (United States)

    Pasquier, Pierre; Dubost, Clément; Boutonnet, Mathieu; Chrisment, Anne; Villevieille, Thierry; Batjom, Emmanuel; Bordier, Emmanuel; Ausset, Sylvain; Puidupin, Marc; Martinez, Jean-Yves; Bay, Christian; Escarment, Jacques; Pons, François; Lenoir, Bernard; Mérat, Stéphane

    2014-09-01

    To improve the mortality rate on the battlefield, and especially the potentially survivable pre-Medical Treatment Facility deaths, Tactical Combat Casualty Care (TCCC) is now considered as a reference for management of combat casualty from the point of injury to the first medical treatment facility. TCCC comprises of a set of trauma management guidelines designed for use on the battlefield. The French Military Health Service also standardised a dedicated training programme, entitled "Sauvetage au Combat" (SC) ("forward combat casualty care"), with the characteristic of forward medicalisation on the battlefield, the medical team being projected as close as possible to the casualty at the point of injury. The aim of our article is to describe the process and the result of the SC training. Records from the French Military Health Service Academy - École du Val-de-Grâce administration, head of the SC teaching programme, defining its guidelines, and supporting its structure and its execution, were examined and analyzed, since the standardisation of the SC training programme in 2008. The total number of trainees was listed following the different courses (SC1, SC2, SC3). At the end of 2013, every deployed combatant underwent SC1 courses (confidential data), 785 health-qualified combatants were graduated for SC2 courses and 672 Role 1 physician-nurse pairs for SC3 courses. The SC concept and programmes were defined in France in 2007 and are now completely integrated into the predeployment training of all combatants but also of French Military Health Service providers. Finally, SC teaching programmes enhance the importance of teamwork in forward combat medicalisation settings. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Depletion of Arabidopsis SC35 and SC35-like serine/arginine-rich proteins affects the transcription and splicing of a subset of genes.

    Science.gov (United States)

    Yan, Qingqing; Xia, Xi; Sun, Zhenfei; Fang, Yuda

    2017-03-01

    Serine/arginine-rich (SR) proteins are important splicing factors which play significant roles in spliceosome assembly and splicing regulation. However, little is known regarding their biological functions in plants. Here, we analyzed the phenotypes of mutants upon depleting different subfamilies of Arabidopsis SR proteins. We found that loss of the functions of SC35 and SC35-like (SCL) proteins cause pleiotropic changes in plant morphology and development, including serrated leaves, late flowering, shorter roots and abnormal silique phyllotaxy. Using RNA-seq, we found that SC35 and SCL proteins play roles in the pre-mRNA splicing. Motif analysis revealed that SC35 and SCL proteins preferentially bind to a specific RNA sequence containing the AGAAGA motif. In addition, the transcriptions of a subset of genes are affected by the deletion of SC35 and SCL proteins which interact with NRPB4, a specific subunit of RNA polymerase II. The splicing of FLOWERING LOCUS C (FLC) intron1 and transcription of FLC were significantly regulated by SC35 and SCL proteins to control Arabidopsis flowering. Therefore, our findings provide mechanistic insight into the functions of plant SC35 and SCL proteins in the regulation of splicing and transcription in a direct or indirect manner to maintain the proper expression of genes and development.

  1. Scalable Implementation of Finite Elements by NASA _ Implicit (ScIFEi)

    Science.gov (United States)

    Warner, James E.; Bomarito, Geoffrey F.; Heber, Gerd; Hochhalter, Jacob D.

    2016-01-01

    Scalable Implementation of Finite Elements by NASA (ScIFEN) is a parallel finite element analysis code written in C++. ScIFEN is designed to provide scalable solutions to computational mechanics problems. It supports a variety of finite element types, nonlinear material models, and boundary conditions. This report provides an overview of ScIFEi (\\Sci-Fi"), the implicit solid mechanics driver within ScIFEN. A description of ScIFEi's capabilities is provided, including an overview of the tools and features that accompany the software as well as a description of the input and output le formats. Results from several problems are included, demonstrating the efficiency and scalability of ScIFEi by comparing to finite element analysis using a commercial code.

  2. Crystal structure of Na3Sc2(PO4)3 at 60 deg C

    International Nuclear Information System (INIS)

    Lazoryak, B.I.; Kalinin, V.B.; Stefanovich, S.Yu.; Efremov, V.A.

    1980-01-01

    The structure of the ferroelectric phase of Na 3 Sc 2 (PO 4 ) 3 compound was studied. Na 3 Sc 2 (PO 4 ) 3 monocrystal heated by a jet of warm N 2 was investigated at 60 deg C. The rhombohedron modification was determined: a=8.927(3), c=22.34(4) A, Z=6, space group R anti 3c. Interatomic distances and inner angles of polyhedrons in Na 3 Sc 2 (PO 4 ) 3 structure were determined

  3. SC3: consensus clustering of single-cell RNA-seq data.

    Science.gov (United States)

    Kiselev, Vladimir Yu; Kirschner, Kristina; Schaub, Michael T; Andrews, Tallulah; Yiu, Andrew; Chandra, Tamir; Natarajan, Kedar N; Reik, Wolf; Barahona, Mauricio; Green, Anthony R; Hemberg, Martin

    2017-05-01

    Single-cell RNA-seq enables the quantitative characterization of cell types based on global transcriptome profiles. We present single-cell consensus clustering (SC3), a user-friendly tool for unsupervised clustering, which achieves high accuracy and robustness by combining multiple clustering solutions through a consensus approach (http://bioconductor.org/packages/SC3). We demonstrate that SC3 is capable of identifying subclones from the transcriptomes of neoplastic cells collected from patients.

  4. Toward low-cost affinity reagents: lyophilized yeast-scFv probes specific for pathogen antigens.

    Directory of Open Access Journals (Sweden)

    Sean A Gray

    Full Text Available The generation of affinity reagents, usually monoclonal antibodies, remains a critical bottleneck in biomedical research and diagnostic test development. Recombinant antibody-like proteins such as scFv have yet to replace traditional monoclonal antibodies in antigen detection applications, in large part because of poor performance of scFv in solution. To address this limitation, we have developed assays that use whole yeast cells expressing scFv on their surfaces (yeast-scFv in place of soluble purified scFv or traditional monoclonal antibodies. In this study, a nonimmune library of human scFv displayed on the surfaces of yeast cells was screened for clones that bind to recombinant cyst proteins of Entamoeba histolytica, an enteric pathogen of humans. Selected yeast-scFv clones were stabilized by lyophilization and used in detection assay formats in which the yeast-scFv served as solid support-bound monoclonal antibodies. Specific binding of antigen to the yeast-scFv was detected by staining with rabbit polyclonal antibodies. In flow cytometry-based assays, lyophilized yeast-scFv reagents retained full binding activity and specificity for their cognate antigens after 4 weeks of storage at room temperature in the absence of desiccants or stabilizers. Because flow cytometry is not available to all potential assay users, an immunofluorescence assay was also developed that detects antigen with similar sensitivity and specificity. Antigen-specific whole-cell yeast-scFv reagents can be selected from nonimmune libraries in 2-3 weeks, produced in vast quantities, and packaged in lyophilized form for extended shelf life. Lyophilized yeast-scFv show promise as low cost, renewable alternatives to monoclonal antibodies for diagnosis and research.

  5. Final Report for DOE Grant Number DE-SC0001481

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Edison [Rice University

    2013-12-02

    This report covers research activities, major results and publications supported by DE-SC-000-1481. This project was funded by the DOE OFES-NNSA HEDLP program. It was a joint research program between Rice University and the University of Texas at Austin. The physics of relativistic plasmas was investigated in the context of ultra-intense laser irradiation of high-Z solid targets. Laser experiments using the Texas Petawatt Laser were performed in the summers of 2011, 2012 and 2013. Numerical simulations of laser-plasma interactions were performed using Monte Carlo and Particle-in-Cell codes to design and support these experiments. Astrophysical applications of these results were also investigated.

  6. DC-SC Photoinjector with Low Emittance at Peking University

    CERN Document Server

    Xiang Rong; Hao, J; Huang, Senlin; Lu Xiang Yang; Quan, Shengwen; Zhang, Baocheng; Zhao, Kui

    2005-01-01

    High average power Free Electron Lasers require the high quality electron beams with the low emittance and the sub-picosecond bunches. The design of DC-SC photoinjector, directly combining a DC photoinjector with an SRF cavity, can produce high average current beam with moderate bunch charge and high duty factor. Because of the DC gun, the emittance increases quickly at the beginning, so a carefully design is needed to control that. In this paper, the simulation of an upgraded design has been done to lower the normalized emittance below 1.5mm·mrad. The photoinjector consists of a DC gap and a 2+1/2-cell SRF cavity, and it is designed to produce 4.2 MeV electron beams at 100pC bunch charge and 81.25MHz repetition rate (8 mA average current).

  7. Preparation and characterization of Sc doped MgB2 wires

    DEFF Research Database (Denmark)

    Grivel, Jean-Claude; Burdusel, M.

    2016-01-01

    The in-situ technique was used to manufacture scandium (Sc) doped MgB2 wires in a composite Cu–Nb sheath. After reaction at 700 °C, at most 1 at.% Mg was replaced by Sc in the MgB2 phase, without significant influence on its superconducting transition temperature. For higher Sc concentrations...... of the precursor powders revealed by DTA measurements than to actual doping. The best performance was obtained in a wire with Mg:Sc = 0.995_0.005 atomic ratio....

  8. Ferromagnetism carried by highly delocalized hybrid states in Sc-doped ZnO thin films

    KAUST Repository

    Benali Kanoun, Mohammed

    2012-05-29

    We present first-principles results for Sc-doped ZnOthin films. Neighboring Sc atoms in the surface and/or subsurface layers are found to be coupled ferromagnetically, where only two of the possible configurations induce spin polarization. In the first configuration, the polarization is carried by the Sc d states as expected for transition metaldoping. However, there is a second configuration which is energetically favorable. It is governed by polarized hybrid states of the Zns, O p, and Sc d orbitals. Such highly delocalized states can be an important ingredient for understanding the magnetism of dopedZnOthin films.

  9. Model of Dees and Rotco for the 600 MeV SC

    CERN Multimedia

    CERN PhotoLab

    1978-01-01

    The accelerating frequency of the 600 MeV Synchro-Cyclotron (SC) was modulated by the varying capacity of a rotating condenser ("Rotco", the most delicate component of the SC). A 1/5-scale model, dating from the design-period of the SC, was used to study improvements to the SC RF-system, and also the acceleration of ions, first Helium and, at the time of this picture, Carbon. In the middle of the picture is the case containing the Dees. To the left, at the wide end of the cone, a rotco. Reinhold Hohbach is busy with measurements. See also 7805235 (Annual Report 1978, p.110).

  10. 48Ca(d,n)49Sc reaction at E/sub d/=20 MeV; proton single-particle states in 49Sc

    International Nuclear Information System (INIS)

    Iwasaki, Y.; Galonsky, A.; Weber, D.J.

    1980-01-01

    The 48 Ca(d,n) 49 Sc reaction has been studied at E/sub d/=20 MeV. Angular distributions of differential cross sections have been obtained for 14 transitions to states in 49 Sc up to an excitation energy of 7.1 MeV. A distorted-wave Born-approximation analysis has been made of the experimental data. With respect to states corresponding to the same proton single-particle orbital, relative values of derived spectroscopic factors are generally in good agreement with those obtained from ( 3 He,d) reaction data. There are remarkable differences between the results from the 48 Ca(d,n) 49 Sc reaction and the 48 Ca( 3 He,d) 49 Sc, however, regarding the dependence of the relative spectroscopic factors on proton single-particle orbitals

  11. Some peculiarities of ScFe2 and ScNi2 interaction with ammonia in the presence of NH4Cl

    International Nuclear Information System (INIS)

    Shilkin, S.P.; Fokin, V.N.; Fokina, Eh.Eh.; Tarasov, B.P.; Korobkov, I.I.

    2000-01-01

    Interaction of ScFe 2 and ScNi 2 intermetallic compounds with ammonia in the presence of NH 4 Cl (10 mass % from intermetallide introduced in reaction) as an activator of the process in initial ammonia pressure 0.6-0.8 MPa is investigated. Possibility of preparation of crystalline intermetallide hydrides and amorphous products in highly dispersed state at different temperature are shown. It is established that intermetallides decompose in ammonia medium at ≥ 450 Deg C [ru

  12. One-Step Partially Purified Lipases (ScLipA and ScLipB from Schizophyllum commune UTARA1 Obtained via Solid State Fermentation and Their Applications

    Directory of Open Access Journals (Sweden)

    Yew Chee Kam

    2017-12-01

    Full Text Available Lipases with unique characteristics are of value in industrial applications, especially those targeting cost-effectiveness and less downstream processes. The aims of this research were to: (i optimize the fermentation parameters via solid state fermentation (SSF; and (ii study the performance in hydrolysis and esterification processes of the one-step partially purified Schizophyllum commune UTARA1 lipases. Lipase was produced by cultivating S. commune UTARA1 on sugarcane bagasse (SB with used cooking oil (UCO via SSF and its production was optimized using Design-Expert® 7.0.0. Fractions 30% (ScLipA and 70% (ScLipB which contained high lipase activity were obtained by stepwise (NH42SO4 precipitation. Crude fish oil, coconut oil and butter were used to investigate the lipase hydrolysis capabilities by a free glycerol assay. Results showed that ScLipA has affinities for long, medium and short chain triglycerides, as all the oils investigated were degraded, whereas ScLipB has affinities for long chain triglycerides as it only degrades crude fish oil. During esterification, ScLipA was able to synthesize trilaurin and triacetin. Conversely, ScLipB was specific towards the formation of 2-mono-olein and triacetin. From the results obtained, it was determined that ScLipA and ScLipB are sn-2 regioselective lipases. Hence, the one-step partial purification strategy proved to be feasible for partial purification of S. commune UTARA1 lipases that has potential use in industrial applications.

  13. One-Step Partially Purified Lipases (ScLipA and ScLipB) from Schizophyllum commune UTARA1 Obtained via Solid State Fermentation and Their Applications.

    Science.gov (United States)

    Kam, Yew Chee; Woo, Kwan Kit; Ong, Lisa Gaik Ai

    2017-12-08

    Lipases with unique characteristics are of value in industrial applications, especially those targeting cost-effectiveness and less downstream processes. The aims of this research were to: (i) optimize the fermentation parameters via solid state fermentation (SSF); and (ii) study the performance in hydrolysis and esterification processes of the one-step partially purified Schizophyllum commune UTARA1 lipases. Lipase was produced by cultivating S. commune UTARA1 on sugarcane bagasse (SB) with used cooking oil (UCO) via SSF and its production was optimized using Design-Expert ® 7.0.0. Fractions 30% ( Sc LipA) and 70% ( Sc LipB) which contained high lipase activity were obtained by stepwise (NH₄)₂SO₄ precipitation. Crude fish oil, coconut oil and butter were used to investigate the lipase hydrolysis capabilities by a free glycerol assay. Results showed that Sc LipA has affinities for long, medium and short chain triglycerides, as all the oils investigated were degraded, whereas Sc LipB has affinities for long chain triglycerides as it only degrades crude fish oil. During esterification, Sc LipA was able to synthesize trilaurin and triacetin. Conversely, Sc LipB was specific towards the formation of 2-mono-olein and triacetin. From the results obtained, it was determined that Sc LipA and Sc LipB are sn -2 regioselective lipases. Hence, the one-step partial purification strategy proved to be feasible for partial purification of S. commune UTARA1 lipases that has potential use in industrial applications.

  14. NiO-ScSZ and Ni 0.9Mg 0.1O-ScSZ-based anodes under internal dry reforming of simulated biogas mixtures

    Science.gov (United States)

    Shiratori, Y.; Sasaki, K.

    Solid oxide fuel cells (SOFCs) with NiO-ScSZ and Ni 0.9Mg 0.1O-ScSZ-based anodes were operated by directly feeding a fuel mixture of CH 4, CO 2 and N 2 (CH 4 to CO 2 ratio of 3:2). Stable operation under constant current load (200 mA cm -2) was achieved with a NiO-ScSZ type anode during 200 h operating hours at 900 °C. Less stable operation occurred with a Ni 0.9Mg 0.1O-ScSZ type anode. In the case of SOFC with Ni 0.9Mg 0.1O-ScSZ as the anode, the methane reforming activity was higher than that with NiO-ScSZ. This was explained by change in the microstructure promoting reforming reactions. However, the addition of MgO resulted in degradation of electrochemical performance due to increase in ohmic resistance of the anode material during operation.

  15. Spinning cylinder experiments SC-I and SC-II: A review of results and analyses provided to the FALSIRE project

    International Nuclear Information System (INIS)

    Morland, E.; Sherry, A.H.

    1993-01-01

    A series of six large-scale experiments have been carried out at AEA Technology using the Spinning Cylinder test facility. Results from two of those experiments (SC-I and SC-II) have been provided to Project FALSIRE and are reviewed in this paper. The Spinning Cylinder tests were carried out using hollow cylinders of 1.4m outer diameter, 0.2m wall thickness and 1.3m length, containing full-length axial defects and fabricated from a modified A508 Class 3 steel. The first Spinning Cylinder test (SC-I) was an investigation of stable ductile growth induced via mechanical (primary) loading and under conditions of contained yielding. Mechanical loading was provided in the hoop direction by rotating the cylinder about its major axis within an enclosed oven. The second test (SC-II) investigated stable ductile growth under severe thermal shock (secondary) loading again under conditions of contained yielding. In this case thermal shock was produced by spraying cold water on the inside surface of the heated cylinder whilst it was rotating. For each experiment, results are presented in terms of a number of variables, eg. crack growth, temperature, stress, strain and applied K and J. In addition, an overview of the analyses of the FALSIRE Phase-1 report is also presented with respect to test SC-I and SC-II. 4 refs., 14 figs., 13 tabs

  16. 77 FR 74472 - Application to Export Electric Energy; Energia Renovable S.C., LLC

    Science.gov (United States)

    2012-12-14

    ... Application to Export Electric Energy; Energia Renovable S.C., LLC AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Energia Renovable S.C., LLC (Energia... application from Energia Renovable for authority to transmit electric energy from the United States to Mexico...

  17. Targeted mutation of the SC3 hydrophobin gene of Schizophyllum commune affects formation of aerial hyphae

    NARCIS (Netherlands)

    vanWetter, MA; Schuren, FHJ; Schuurs, TA; Wessels, JGH

    1996-01-01

    The SC3 hydrophobin gene of Schizophyllum commune was disrupted by homologous integration of an SC3 genomic fragment interrupted by a phleomycin resistance cassette. The phenotype of the mutant was particularly clear in sealed plates in which formation of aerial hyphae was blocked. In non-sealed

  18. Implementation of LTE SC-FDMA on the USRP2 Software Defined Radio Platform

    DEFF Research Database (Denmark)

    Jørgensen, Peter Bjørn; Hansen, Thomas Lundgaard; Sørensen, Troels Bundgaard

    2011-01-01

    In this paper we discuss the implementation of a Single Carrier Frequency Division Multiple Access (SC-FDMA) transceiver running over the Universal Software Radio Peripheral 2 (USRP2). SC-FDMA is the air interface which has been selected for the uplink in the latest Long Term Evolution (LTE...

  19. Construction of human nonimmune library and selection of scFvs against IL-33.

    Science.gov (United States)

    Yuan, Qing; Huang, Li; Wang, Xu; Wu, Yuchuan; Gao, Yan; Li, Chengwen; Nian, Siji

    2012-06-01

    Interleukin (IL) 33 plays very important roles in inflammatory and allergic diseases. To select human single-chain Fv fragments (scFvs) against IL-33, a nonimmune phage library system was constructed. The full-length cDNA library was synthesized for amplification of the variable heavy chain (V(H)) and variable light chain (V(L)). By overlapping extension PCR for splicing V(H) and V(L), the full-length scFv library DNA were amplified and then transformed into Escherichia coli TG1. The scFv library was constructed successfully which contained 2.5×10(8) independent clones with full-length scFv inserts. The results of fingerprint maps of the scFvs by BstN I and DNA sequencing from the library at random proved that the library was diverse. The human IL-33 was amplified, expressed, and purified. The purified IL-33 with bioactivity was biotinylated and used as antigen for selection of scFv library by phage display. After three rounds of affinity selection, about 30 % of clones have specific binding activity with IL-33. Five of those with good binding activity were transformed into E. coli strain HB2151 for soluble expression. The selected scFvs were further identified by western blot and sequencing. Those selected scFvs could be used for further research of their effect on inflammatory and allergic diseases such as asthma by blockade of IL-33.

  20. Use of antifungal Saponin SC-2 of Solanum chrysotrichum for the ...

    African Journals Online (AJOL)

    Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ...

  1. 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells

    International Nuclear Information System (INIS)

    Fu, Meili; Wan, Fuqiang; Li, Zhengling; Zhang, Fenghua

    2016-01-01

    The aim of the present study is to investigate the potential anti-hepatocellular carcinoma (HCC) cell activity by 4SC-202, a novel class I HDAC inhibitor (HDACi). The associated signaling mechanisms were also analyzed. We showed that 4SC-202 treatment induced potent cytotoxic and proliferation–inhibitory activities against established HCC cell lines (HepG2, HepB3, SMMC-7721) and patient-derived primary HCC cells. Further, adding 4SC-202 in HCC cells activated mitochondrial apoptosis pathway, which was evidenced by mitochondrial permeability transition pore (mPTP) opening, cytochrome C cytosol release and caspase-3/-9 activation. Inhibition of this apoptosis pathway, by caspase-3/-9 inhibitors, mPTP blockers, or by shRNA-mediated knockdown of cyclophilin-D (Cyp-D, a key component of mPTP), significantly attenuated 4SC-202-induced HCC cell death and apoptosis. Reversely, over-expression of Cyp-D enhanced 4SC-202's sensitivity in HCC cells. Further studies showed that 4SC-202 induced apoptosis signal-regulating kinase 1 (ASK1) activation, causing it translocation to mitochondria and physical association with Cyp-D. This mitochondrial ASK1-Cyp-D complexation appeared required for mediating 4SC-202-induced apoptosis activation. ASK1 stable knockdown by targeted-shRNAs largely inhibited 4SC-202-induced mPTP opening, cytochrome C release, and following HCC cell apoptotic death. Together, we suggest that 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to potently inhibit human HCC cells. - Highlights: • 4SC-202 exerts potent anti-proliferative and cytotoxic activity against established/primary HCC cells. • SC-202-induced anti-HCC cell activity relies on caspase-dependent apoptosis activation. • 4SC-202 activates Cyp-D-dependent mitochondrial apoptosis pathway in HCC cells. • 4SC-202 activates ASK1 in HCC cells, causing it translocation to mitochondria. • Mitochondrial ASK1-Cyp-D complexation mediates 4SC-202's activity in HCC cells.

  2. 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Meili, E-mail: fumeilidrlinyi@tom.com [Department of Infectious Disease, Linyi People' s Hospital, Linyi 276000 (China); Wan, Fuqiang [Department of Head and Neck Surgery, Linyi Tumor Hospital, Linyi 276000 (China); Li, Zhengling [Department of Nursing, Tengzhou Central People' s Hospital, Tengzhou 277500 (China); Zhang, Fenghua [Department of Operating Room, Linyi People' s Hospital, Linyi 276000 (China)

    2016-03-04

    The aim of the present study is to investigate the potential anti-hepatocellular carcinoma (HCC) cell activity by 4SC-202, a novel class I HDAC inhibitor (HDACi). The associated signaling mechanisms were also analyzed. We showed that 4SC-202 treatment induced potent cytotoxic and proliferation–inhibitory activities against established HCC cell lines (HepG2, HepB3, SMMC-7721) and patient-derived primary HCC cells. Further, adding 4SC-202 in HCC cells activated mitochondrial apoptosis pathway, which was evidenced by mitochondrial permeability transition pore (mPTP) opening, cytochrome C cytosol release and caspase-3/-9 activation. Inhibition of this apoptosis pathway, by caspase-3/-9 inhibitors, mPTP blockers, or by shRNA-mediated knockdown of cyclophilin-D (Cyp-D, a key component of mPTP), significantly attenuated 4SC-202-induced HCC cell death and apoptosis. Reversely, over-expression of Cyp-D enhanced 4SC-202's sensitivity in HCC cells. Further studies showed that 4SC-202 induced apoptosis signal-regulating kinase 1 (ASK1) activation, causing it translocation to mitochondria and physical association with Cyp-D. This mitochondrial ASK1-Cyp-D complexation appeared required for mediating 4SC-202-induced apoptosis activation. ASK1 stable knockdown by targeted-shRNAs largely inhibited 4SC-202-induced mPTP opening, cytochrome C release, and following HCC cell apoptotic death. Together, we suggest that 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to potently inhibit human HCC cells. - Highlights: • 4SC-202 exerts potent anti-proliferative and cytotoxic activity against established/primary HCC cells. • SC-202-induced anti-HCC cell activity relies on caspase-dependent apoptosis activation. • 4SC-202 activates Cyp-D-dependent mitochondrial apoptosis pathway in HCC cells. • 4SC-202 activates ASK1 in HCC cells, causing it translocation to mitochondria. • Mitochondrial ASK1-Cyp-D complexation mediates 4SC-202's activity in HCC cells.

  3. An algorithm J-SC of detecting communities in complex networks

    Science.gov (United States)

    Hu, Fang; Wang, Mingzhu; Wang, Yanran; Hong, Zhehao; Zhu, Yanhui

    2017-11-01

    Currently, community detection in complex networks has become a hot-button topic. In this paper, based on the Spectral Clustering (SC) algorithm, we introduce the idea of Jacobi iteration, and then propose a novel algorithm J-SC for community detection in complex networks. Furthermore, the accuracy and efficiency of this algorithm are tested by some representative real-world networks and several computer-generated networks. The experimental results indicate that the J-SC algorithm can accurately and effectively detect the community structure in these networks. Meanwhile, compared with the state-of-the-art community detecting algorithms SC, SOM, K-means, Walktrap and Fastgreedy, the J-SC algorithm has better performance, reflecting that this new algorithm can acquire higher values of modularity and NMI. Moreover, this new algorithm has faster running time than SOM and Walktrap algorithms.

  4. Phase relationship in AL-Cu-Sc alloys at 450-500 deg C

    International Nuclear Information System (INIS)

    Kharakterova, M.L.

    1991-01-01

    Al-Cu-Sc alloys containing up to 40% Cu and up to 6% Sc at 450 deg C and 500 deg C are studied using light microscopy, X-ray-spectral microanalysis, X-ray diffraction analysis, scanning electron microscopy, measurement of microhardness and electric resistance. It is determined, that in equilibrium with aluminium solid solution under the given temperature ther are Al 3 Sc, CuAl 2 phases of the respective binary systems and W (ScCu 6.6-4 Al 5.4-8 ) ternary phase. Isothermal cross sections of Al-Cu-Sc system at 450 and 500 deg C are plotted. Microhardness of equilibrium phases is measured. Combined solubility of copper and scandium in aluminium is determined

  5. Sc237 hamster PrPSc and Sc237-derived mouse PrPSc generated by interspecies in vitro amplification exhibit distinct pathological and biochemical properties in tga20 transgenic mice.

    Science.gov (United States)

    Yoshioka, Miyako; Imamura, Morikazu; Okada, Hiroyuki; Shimozaki, Noriko; Murayama, Yuichi; Yokoyama, Takashi; Mohri, Shirou

    2011-05-01

    Prions are the infectious agents responsible for transmissible spongiform encephalopathy, and are primarily composed of the pathogenic form (PrP(Sc)) of the host-encoded prion protein (PrP(C)). Recent studies have revealed that protein misfolding cyclic amplification (PMCA), a highly sensitive method for PrP(Sc) detection, can overcome the species barrier in several xenogeneic combinations of PrP(Sc) seed and PrP(C) substrate. Although these findings provide valuable insight into the origin and diversity of prions, the differences between PrP(Sc) generated by interspecies PMCA and by in vivo cross-species transmission have not been described. This study investigated the histopathological and biochemical properties of PrP(Sc) in the brains of tga20 transgenic mice inoculated with Sc237 hamster scrapie prion and PrP(Sc) from mice inoculated with Sc237-derived mouse PrP(Sc), which had been generated by interspecies PMCA using Sc237 as seed and normal mouse brain homogenate as substrate. Tga20 mice overexpressing mouse PrP(C) were susceptible to Sc237 after primary transmission. PrP(Sc) in the brains of mice inoculated with Sc237-derived mouse PrP(Sc) and in the brains of mice inoculated with Sc237 differed in their lesion profiles and accumulation patterns, Western blot profiles, and denaturant resistance. In addition, these PrP(Sc) exhibited distinctive virulence profiles upon secondary passage. These results suggest that different in vivo and in vitro environments result in propagation of PrP(Sc) with different biological properties. © 2011 The Societies and Blackwell Publishing Asia Pty Ltd.

  6. Preliminary Tests Of The Decris-sc Ion Source

    CERN Document Server

    Efremov, A; Bechterev, V; Bogomolov, S L; Bondarenko, P G; Datskov, V I; Dmitriev, S; Drobin, V; Lebedev, A; Leporis, M; Malinowski, H; Nikiforov, A; Paschenko, S V; Seleznev, V; Shishov, Yu A; Smirnov, Yu; Tsvineva, G; Yakovlev, B; Yazvitsky, N Yu

    2004-01-01

    A new "liquid He-free" superconducting Electron Cyclotron Resonance Ion Source DECRIS-SC, to be used as injector for the IC-100 small cyclotron, has been designed by FLNR and LHE JINR. The main feature is that a compact refrigerator of Gifford-McMahon type is used to cool the solenoid coils. For the reason of very small cooling power at 4.2 K (about 1 W) our efforts were to optimize the magnetic structure and minimize an external heating of the coils. The maximum magnetic field strength is 3 T and 2 T in injection and extraction region respectively. For the radial plasma confinement a hexapole made of NdFeB permanent magnet is used. The source will be capable of ECR plasma heating using different frequencies (14 GHz or 18 GHz). To be able to deliver usable intensities of solids, the design is also allow axial access for evaporation oven and metal samples using the plasma sputtering technique. Very preliminary results of the source test are presented.

  7. High power test of the input coupler KEKB SC cavity

    International Nuclear Information System (INIS)

    Mitsunobu, S.; Asano, K.; Furuya, T.; Tajima, T.; Takahashi, T.; Ishi, Y.; Kijima, Y.; Sennyu, K.

    1996-01-01

    The superconducting cavity for the KEK B-factory needs a high power input coupler of more than 500 kW. This coupler is investigated. A coaxial antenna coupler is used as an input coupler, which is the same type as what has used for the TRISTAN SC cavities. The ceramic window of the coupler is a 152 D coaxial. The inner conductor is cooled by water and the outer conductor is cooled by cold He gas. To increase heat exchange efficiency and to prevent a local heating spot, Cu fins were attached on the outside surface of the outer conductor of the coupler. After 9 hours of RF conditioning, a CW traveling RF power of 800 kW could be successfully supplied to the first two couplers in a test bench for more than 30 minutes. Most of the processing time was spent to overcome the multipactoring level of 50 kW and 160 kW. The second two couplers were treated by ozonized ultra pure water rinsing, and the multipactoring level of 50 kW disappeared. After almost same conditioning time the second couplers reached 800 kW. Both pairs of coupler could be operated in a short time at 850 kW which is our klystron power limit. (author)

  8. Conceptual design of SC magnet system for ITER, (2)

    International Nuclear Information System (INIS)

    Koizumi, Koichi; Hasegawa, Mitsuru; Yoshida, Kiyoshi

    1991-08-01

    The International Thermonuclear Experimental Reactor (ITER) is an experimental tokamak machine testing the basic plasma performance and technologies required for future tokamak reactor. The design proposals for the Superconducting (SC) Magnet System from Japan were summarized by the Fusion Experimental Reactor (FER) Design Team and the Superconducting Magnet Laboratory of the Japan Atomic Energy Research Institute (JAERI). This report is one of the series reports on 'Conceptual design of superconducting magnet system for ITER', and describes the major results of the stress analysis regarding the Toroidal Field (TF) coil, the Center Solenoid (CS) coil and the Equilibrium Field (EF) coil and their support structures. Among the design issues, the mechanical design of the coil system was one of the most critical items, not only because of the huge electromagnetic loads due to large size and high magnetic field, but also because of the demand of high reliability under neutron irradiation. In order to satisfy both the coil performance and the mechanical reliability, different types of conductors were employed for each coils. The mechanical behaviors and the safety margin of each coil were analyzed by using finite element method (FEM) of MSC/NASTRAN. The procedure to obtain the equivalent winding stiffness employed for the each FEM analysis is also described in this report. The details on the coil specifications, conductor design and mechanical design for each coils are described in other report of the series reports. (J.P.N.)

  9. New nuclear data evaluations for Ca and Sc isotopes

    International Nuclear Information System (INIS)

    Koning, Arjan; Duijvestijn, Marieke

    2007-01-01

    New ENDF-6 formatted nuclear data libraries are presented for 40,42,43,44,46,48 Ca and 45 Sc, for incident neutrons and protons. Apart from the resonance range, which we have adopted from the best available source in existing libraries, the nuclear data evaluations are completely revised in the 0-20MeV energy range, and, moreover, extend up to 200 MeV. This collection of isotopic evaluations is created by using the nuclear model code TALYS with a consistent set of input parameters for all isotopes. The most important nuclear reaction models needed for our data files are described. We have intended to make these evaluations complete in their description of reaction channels and use a consistent method to store the data in ENDF-6 format, which include cross sections, angular distributions, double-differential spectra, discrete and continuum photon production cross sections, and residual production (activation) cross sections including isomers. It is shown that the data present in our libraries give an improved agreement with the existing basic experimental data. (author)

  10. Final Technical Report for DE-SC0012297

    Energy Technology Data Exchange (ETDEWEB)

    Dell' Antonio, Ian [Brown Univ., Providence, RI (United States)

    2017-08-01

    This is the final report on the work performed in award DE-SC0012297, Cosmic Frontier work in support of the LSST Dark Energy Science Collaboration's work to develop algorithms, simulations, and statistical tests to ensure optimal extraction of the dark energy properties from galaxy clusters observed with LSST. This work focused on effects that could produce a systematic error on the measurement of cluster masses (that will be used to probe the effects of dark energy on the growth of structure). These effects stem from the deviations from pure ellipticity of the gravitational lensing signal and from the blending of light of neighboring galaxies. Both these effects are expected to be more significant for LSST than for the stage III experiments such as the Dark Energy Survey. We calculate the magnitude of the mass error (or bias) for the first time and demonstrate that it can be treated as a multiplicative correction and calibrated out, allowing mass measurements of clusters from gravitational lensing to meet the requirements of LSST's dark energy investigation.

  11. Radiolabeling of DOTATOC with the long-lived positron emitter {sup 44}Sc

    Energy Technology Data Exchange (ETDEWEB)

    Pruszynski, Marek; Majkowska-Pilip, Agnieszka [Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warszawa (Poland); Loktionova, Natalia S.; Eppard, Elisabeth [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany); Roesch, Frank, E-mail: frank.roesch@uni-mainz.de [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany)

    2012-06-15

    The positron-emitting radionuclide {sup 44}Sc with a half-life of 3.97 h and a {beta}{sup +} branching of 94.3% is of potential interest for clinical PET. As so far it is available from a {sup 44}Ti/{sup 44}Sc generator in Mainz, where long-lived {sup 44}Ti decays to no-carrier-added (nca) {sup 44}Sc. The {sup 44}Sc is a trivalent metal cation and should be suitable for complexation with many well established bifunctional chelators conjugated to peptides or other molecular targeting vectors. Thus, the aim of this work was to investigate the potential of {sup 44}Sc for labeling of DOTA-conjugated peptides. DOTA-D-Phe{sup 1}-Tyr{sup 3}-octreotide (DOTATOC) was used as a model molecule to study and optimize labeling procedure. Reaction parameters such as buffer conditions, concentration of peptide, pH range, reaction temperature and time were optimized. Addition of 21 nmol of DOTATOC to {sup 44}Sc in ammonium acetate buffer pH 4.0 provided labeling yields >98% within 25 min of heating in an oil-bath at 95 Degree-Sign C. This time can be reduced to 3 min only by applying microwave supported heating. {sup 44}Sc-DOTATOC was found to be stable in 0.9% NaCl, PBS pH 7.4, fetal calf and human serums, and also in the presence of competing metal cations (Fe{sup 3+}, Ca{sup 2+}, Cu{sup 2+}, Mg{sup 2+}), as well as other ligand competitors, like EDTA and DTPA, even after almost 25 h incubation at 37 Degree-Sign C. Present study shows that nca {sup 44}Sc forms stable complexes with the macrocyclic ligand DOTA and that {sup 44}Sc-DOTATOC and analog targeting vectors may be synthesized for further preclinical and clinical investigations. - Highlights: Black-Right-Pointing-Pointer Labeling of somatostatin analouges with positron emitter {sup 44}Sc was tested. Black-Right-Pointing-Pointer DOTATOC was labeled with {sup 44}Sc isotope. Black-Right-Pointing-Pointer Optimal conditions for {sup 44}Sc-DOTATOC synthesis were found. Black-Right-Pointing-Pointer Stability of {sup 44}Sc

  12. Safety Training: Basic safety courses available everyday in building 55

    CERN Multimedia

    2005-01-01

    One month ago, SC launched the new organization for basic safety courses. A video lasting 50 minutes runs daily at 14.00 and 15.00 in the registration building. The first session started on 13 October. For your information, since the video was first shown, 260 people have attended the English basic safety course. This means an average of 60 people per week. SC would like to thank the Departments who permitted this project to reach its goal, and particularly IT, TS and FI. The French version of this course will run daily from 30 November , at 9:00 am and at 10:00 am. SC would like to thank you all in advance for contributing to change the old habits of the past organization by encouraging people you work with to follow the safety courses upon arrival, and not only on Tuesdays. For more information, please go to the following link: http://safety-commission.web.cern.ch/safety-commission/SC-site/sc_pages/training/basic.html FORMATION EN SECURITE SAFETY TRAINING safety.training@cern.ch

  13. Authenticated, private, and secured smart cards (APS-SC)

    Science.gov (United States)

    Szu, Harold; Mehmood, Amir

    2006-04-01

    From historical perspective, the recent advancements in better antenna designs, low power circuitry integrations and inexpensive fabrication materials have made possible a miniature counter-measure against Radar, a clutter behaving like a fake target return called Digital Reflection Frequency Modulation (DRFM). Such a military counter-measure have found its way in the commerce as a near field communication known as Radio Frequency Identification (RFID), a passive or active item tag T attached to every readable-writable Smart Card (SC): Passports ID, medical patient ID, biometric ID, driver licenses, book ID, library ID, etc. These avalanche phenomena may be due to the 3 rd Gen phones seeking much more versatile & inexpensive interfaces, than the line-of-sight bar-code optical scan. Despite of the popularity of RFID, the lacking of Authenticity, Privacy and Security (APS) protection restricted somewhat the wide spread commercial, financial, medical, legal, and militarily applications. Conventional APS approach can obfuscate a private passkey K of SC with the tag number T or the reader number R, or both, i.e. only T*K or R*K or both will appear on them, where * denotes an invertible operation, e.g. EXOR, but not limited to it. Then, only the authentic owner, knowing all, can inverse the operation, e.g. EXOR*EXOR= I to find K. However, such an encryption could be easily compromised by a hacker seeking exhaustively by comparison based on those frequently used words. Nevertheless, knowing biological wetware lesson for power of pairs sensors and Radar hardware counter-measure history, we can counter the counter-measure DRFM, instead using one RFID tag per SD, we follow the Nature adopting two ears/tags, e.g. each one holding portions of the ID or simply two different ID's readable only by different modes of the interrogating reader, followed by brain central processor in terms of nonlinear invertible shufflers mixing two ID bits. We prefer to adopt such a hardware

  14. Environmentally friendly processing of photoresists in scCO2 and decamethyltetrasiloxane

    Science.gov (United States)

    Ouyang, Christine Y.; Lee, Jin-Kyun; Sha, Jing; Ober, Christopher K.

    2010-04-01

    The chemical waste generated in today's microelectronic fabrication processes has driven the need to develop a more environmentally benign process. Supercritical CO2 (scCO2) has been evaluated as an environmentally friendly solvent for photoresist development. It is nontoxic, nonflammable, and inert under most conditions. It also possesses advantages such as liquid-like densities, gas-like diffusivity, and zero surface tension. Although scCO2 is a poor solvent for most polymers, certain fluorine-and silicon-containing polymers have shown solubility in scCO2. Previously, negative-tone patterns of 100nm have also been developed in scCO2 using conventional photoresists such as ESCAP and PBOCST with the aid of fluorinated quaternary ammonium salts (QAS). However, the incorporation of fluorine degrades plasma etch resistance, and because of their persistence in nature, fluorinated compounds are coming under increased scrutiny. In order to make the process more environmentally benign, the elimination of fluorine is desirable. Some molecular glass photoresists without the incorporation of fluorine and silicon have thus been designed and synthesized to be processed in scCO2. In addition to scCO2, another environmentally friendly, low VOC solvent, decamethyltetrasiloxane has also been investigated to develop conventional photoresists. In this paper, we demonstrate the patterning of photoresists in both scCO2 and decamethyltetrasiloxane.

  15. Chronic Hypoxia Suppresses the Co2 Response of Solitary Complex (Sc) Neurons from Rats

    Science.gov (United States)

    Nichols, Nicole L.; Wilkinson, Katherine A.; Powell, Frank L.; Dean, Jay B.; Putnam, Robert W.

    2009-01-01

    We studied the effect of chronic hypobaric hypoxia (CHx; 10-11% O2) on the response to hypercapnia (15% CO2) of individual solitary complex (SC) neurons from adult rats. We simultaneously measured the intracellular pH and firing rate responses to hypercapnia of SC neurons in superfused medullary slices from control and CHx-adapted adult rats using the blind whole cell patch clamp technique and fluorescence imaging microscopy. We found that CHx caused the percentage of SC neurons inhibited by hypercapnia to significantly increase from about 10% up to about 30%, but did not significantly alter the percentage of SC neurons activated by hypercapnia (50% in control versus 35% in CHx). Further, the magnitudes of the responses of SC neurons from control rats (chemosensitivity index for activated neurons of 166±11% and for inhibited neurons of 45±15%) were the same in SC neurons from CHx-adapted rats. This plasticity induced in chemosensitive SC neurons by CHx appears to involve intrinsic changes in neuronal properties since they were the same in synaptic blockade medium. PMID:19619674

  16. New separation method of no-carrier-added {sup 47}Sc from titanium targets

    Energy Technology Data Exchange (ETDEWEB)

    Bartos, B.; Majkowska, A.; Kasperek, A.; Krajewski, S.; Bilewicz, A. [Institute of Nuclear Chemistry and Technology, Warszawa (Poland). Nuclear Chemistry and Radiochemistry Center

    2012-07-01

    Radionuclides with medium energy beta emission and a several day half-life are attractive candidates for radioimmunotherapy. Among the most promising in this category is {sup 47}Sc produced by fast neutron irradiation (E{sub n} > 1 MeV) of titanium target with high energy neutrons in {sup 47}Ti(n,p){sup 47}Sc nuclear reaction. In the previously reported production scheme the dissolution of the TiO{sub 2} target in hot concentrated H{sub 2}SO{sub 4} and evaporation of the resulting solution were the most time-consuming steps. The present paper describes new, simple and efficient production method of {sup 47}Sc, where the slow dissolution of the target is avoided. After irradiation in fast neutron flux {sup 47}TiO{sub 2} and Li{sub 2}{sup 47}TiF{sub 6} targets were dissolved in HF solutions. Next {sup 47}Sc was separated from the target using anion exchange resin Dowex 1 with 0.4 M HF + 0.06 M HNO{sub 3} solution as eluent. The eluted {sup 47}Sc was adsorbed on cation exchange resin and eluted with 0.5 M of ammonium acetate. The 47Sc separation yield in the proposed procedure is about 90% with the separation time less than 2 h. The obtained no-carrier-added {sup 47}Sc was used to label DOTATATE conjugate with 96% labeling yield. (orig.)

  17. One-neutron knockout from 51-55Sc

    International Nuclear Information System (INIS)

    Schwertel, S.; Maierbeck, P.; Gernhaeuser, R.; Bildstein, V.; Boehmer, M.; Eppinger, K.; Faestermann, T.; Friese, J.; Fabbietti, L.; Maier, L.; Winkler, S.; Kruecken, R.; Kroell, T.; Alvarez-Pol, H.; Benjamim, E.A.; Benlliure, J.; Caamano, M.; Cortina-Gil, D.; Gascon, M.; Kurtukian, T.; Perez, D.; Rodriguez-Tajes, C.; Aksouh, F.; Aumann, T.; Behr, K.; Boretzky, K.; Bruenle, A.; Chatillon, A.; Chulkov, L.V.; Geissel, H.; Gerl, J.; Gorska, M.; Kojouharov, I.; Klimkiewicz, A.; Kurz, N.; Nociforo, C.; Schaffner, H.; Simon, H.; Stanoiu, M.; Suemmerer, K.; Weick, H.; Borge, M.J.G.; Pascual-Izarra, C.; Perea, A.; Tengblad, O.; Buerger, A.; Casarejos, E.; Brown, B.A.; Enders, J.; Schrieder, G.; Hansen, P.G.; Jonson, B.; Nyman, G.; Kanungo, R.; Kiselev, O.; Larsson, K.; Le Bleis, T.; Mahata, K.; Nilsson, T.; Prochazka, A.; Rossi, D.; Sitar, B.; Otsuka, T.; Tostevin, J.A.; Rae, W.D.M.

    2012-01-01

    Results are presented from a one-neutron knockout experiment at relativistic energies of ∼ 420 A MeV on 51-55 Sc using the GSI Fragment Separator as a two-stage magnetic spectrometer and the MINIBALL array for gamma-ray detection. Inclusive longitudinal momentum distributions and cross-sections were measured enabling the determination of the contributions corresponding to knockout from the νp 1/2 , νp 3/2 , (L = 1) and νf 7/2 , νf 5/2 (L = 3) neutron orbitals. The observed L = 1 and L = 3 contributions are compared with theoretical cross-sections using eikonal knockout theory and spectroscopic factors from shell model calculations using the GXPF1A interaction. The measured inclusive knockout cross-sections generally follow the trends expected theoretically and given by the spectroscopic strength predicted from the shell model calculations. However, the deduced L = 1 cross-sections are generally 30-40% higher while the L = 3 contributions are about a factor of two smaller than predicted. This points to a promotion of neutrons from the νf 7/2 to the νp 3/2 orbital indicating a weakening of the N = 28 shell gap in these nuclei. While this is not predicted for the phenomenological GXPF1A interaction such a weakening is predicted by recent calculations using realistic low-momentum interactions V low k obtained by evolving a chiral N3LO nucleon-nucleon potential. (orig.)

  18. Synergistic capture of Clostridium botulinum Type A neurotoxin by scFv antibodies to novel epitopes

    Energy Technology Data Exchange (ETDEWEB)

    Gray, Sean A.; Barr, John R.; Kalb, Suzanne R.; Marks, James D.; Baird, Cheryl L.; Cangelosi, Gerard A.; Miller, Keith D.; Feldhaus, Michael J.

    2011-10-01

    A non-immune library of human single chain fragment variable (scFv) antibodies displayed on Saccharomyces cerevisiae was screened for binding to the Clostridium botulinum neurotoxin serotype A binding domain [BoNT/A (Hc)] with the goal of identifying scFv to novel epitopes. To do this, an antibody-mediated labeling strategy was used in which antigen-binding yeast clones were selected after labeling with previously characterized monoclonal antibodies (MAbs) specific to the Hc. Twenty unique scFv clones were isolated that bound Hc. Of these, three also bound to full-length BoNT/A toxin complex with affinities ranging from 5 nM to 170 nM. Epitope binning showed that the three unique clones recognized at least two epitopes that were distinct from one another and from the detection MAbs. After production in E. coli, the scFv were coupled to magnetic particles and tested for their ability to capture BoNT/A holotoxin using an Endopep-MS assay. In this assay, toxin captured by scFv coated magnetic particles was detected by incubation of the complex with a peptide containing a BoNT/A-specific cleavage sequence. Mass spectrometry was used to detect the ratio of intact peptide to cleavage products as evidence for toxin capture. When tested individually, each of the scFv showed a weak positive Endopep-MS result. However, when the particles were coated with all three scFv simultaneously, they exhibited significantly higher Endopep-MS activity, consistent with synergistic binding. These results demonstrate novel approaches toward the isolation and characterization of scFv antibodies specific to unlabeled antigen. They also provide evidence that distinct scFv antibodies can work synergistically to increase the efficiency of antigen capture onto a solid support.

  19. Flow cytometry-based methods for assessing soluble scFv activities and detecting pathogen antigens in solution

    Energy Technology Data Exchange (ETDEWEB)

    Gray, Sean; Weigel, Kris M.; Miller, Keith D.; Ndung' u, Joseph; Buscher, Philippe; Tran, Thao N.; Baird, Cheryl L.; Cangelosi, Gerard A.

    2010-04-01

    Novel methods are reported for evaluating and utilizing single chain fragment variable (scFv) antibodies derived from yeast-display libraries. Yeast-display was used to select scFv specific to invariant surface glycoproteins (ISG) of Trypanosoma brucei. A limiting step in the isolation of scFv from nonimmune libraries is the conversion of highly active yeast-displayed scFv into soluble antibodies that can be used in standard immunoassays. Challenges include limited solubility or activity following secretion and purification of scFv. For this reason, few scFv derived from yeast-display platforms have moved into development and implementation as diagnostic reagents. To address this problem, assays were developed that employ both yeastdisplayed and secreted scFv as analytical reagents. The first is a competitive inhibition flow cytometry (CIFC) assay that detects secreted scFv by virtue of its ability to competitively inhibit the binding of biotinylated antigen to yeast-displayed scFv. The second is an epitope binning assay that uses secreted scFv toidentify additional yeast-displayed scFv that bind nonoverlapping or noncompeting epitopes on an antigen. The epitope binning assay was used not only to identify sandwich assay pairs with yeast-displayed scFv, but also to identify active soluble scFv present in low concentration in a crude expression extract. Finally, a CIFC assay was developed that bypasses entirely the need for soluble scFv expression, by using yeast displayed scFv to detect unlabeled antigen in samples. These methods will facilitate the continued development and practical implementation of scFv derived from yeast-display libraries.

  20. South Carolina Area Health Education Consortium Disaster Preparedness and Response Training Network: an emerging partner in preparedness training.

    Science.gov (United States)

    Kennedy, Beth; Carson, Deborah Stier; Garr, David

    2009-03-01

    The South Carolina Area Health Education Consortium (SC AHEC) was funded in 2003 to train healthcare professionals in disaster preparedness and response. During the 5 years of funding, its Disaster Preparedness and Response Training Network evolved from disaster awareness training to competency-based instruction and performance assessment. With funding from the assistant secretary for preparedness and response (ASPR), a project with implications for national dissemination was developed to evaluate 2 aspects of preparedness training for community-based healthcare professionals. The SC AHEC designed disaster preparedness curricula and lesson plans, using a consensus-building technique, and then (1) distributed sample curricula and resources through the national Area Health Education Center system to assess an approach for providing preparedness training and (2) delivered a standardized preparedness curriculum to key influential thought leaders from 4 states to evaluate the effectiveness and acceptability of the curriculum. As a result of this project, the SC AHEC recommends that preparedness training for community-based practitioners needs to be concise and professionally relevant. It should be integrated into existing healthcare professions education programs and continuing education offerings. The project also demonstrated that although AHECs may be interested and well suited to incorporate preparedness training as part of their mission, more work needs to be done if they are to assume a prominent role in disaster preparedness training.

  1. β decay and isomeric properties of neutron-rich Ca and Sc isotopes

    International Nuclear Information System (INIS)

    Crawford, H. L.; Mantica, P. F.; Berryman, J. S.; Stoker, J. B.; Janssens, R. V. F.; Carpenter, M. P.; Kay, B. P.; Lauritsen, T.; Zhu, S.; Broda, R.; Cieplicka, N.; Fornal, B.; Grinyer, G. F.; Minamisono, K.; Hoteling, N.; Stefanescu, I.; Walters, W. B.

    2010-01-01

    The isomeric and β-decay properties of neutron-rich 53-57 Sc and 53,54 Ca nuclei near neutron number N=32 are reported, and the low-energy level schemes of 53,54,56 Sc and 53-57 Ti are presented. The low-energy level structures of the 21 Sc isotopes are discussed in terms of the coupling of the valence 1f 7/2 proton to states in the corresponding 20 Ca cores. Implications with respect to the robustness of the N=32 subshell closure are discussed, as well as the repercussions for a possible N=34 subshell closure.

  2. Cloning and expression of murine SC1, a gene product homologous to SPARC.

    Science.gov (United States)

    Soderling, J A; Reed, M J; Corsa, A; Sage, E H

    1997-06-01

    A number of cDNAs (SC1, QR1, and hevin) have been shown to be similar to SPARC (secreted protein acidic and rich in cysteine), a matricellular protein that regulates cell adhesion, cell cycle, and matrix assembly and remodeling. These proteins are 61-65% identical in the final 200 residues of their C-termini; their N-terminal sequences are related but more divergent. All have an overall acidic pl, with a follistatin-like region that is rich in cysteine, and a Ca+2 binding consensus sequence at the C-terminus. Using degenerate primers representing the most highly conserved region in SPARC, SC1, and QR1, we identified a 300-BP SC1 clone in a primary polymerase chain reaction (PCR) screen of a mouse brain cDNA library. This cDNA was used to obtain a full-length clone, which hybridized to a 2.8-KB RNA abundant in brain. Mouse SC1 displays a similarity of 70% to mouse SPARC at the amino acid level. Northern blot and RNAse protection assays revealed a 2.8-KB mRNA expressed at moderate levels (relative to brain) in mouse heart, adrenal gland, epididymis, and lung, and at low levels in kidney, eye, liver, spleen, submandibular gland, and testis. In contrast to SPARC, in situ hybridization showed expression of SC1 mRNA in the tunica media and/or adventitia of medium and large vessels; transcripts were not detected in capillaries, venules, or large lymphatics. The distribution of transcripts for SC1 was also different from that of SPARC in several organs, including adrenal gland, lung, heart, liver, and spleen. Moreover, SC1 mRNA was not evident in endothelium cultured from rat heart, bovine fetal and adult aorta, mouse aorta, human omentum, and bovine retina. Cultured smooth muscle cells and fibroblasts also failed to express SC1 mRNA. The absence of SC1 transcript in cultured cells indicates that the SC1 gene is potentially sensitive to regulatory factors in serum or to a three-dimensional architecture conferred by the extracellular matrix that is lacking in vitro. In

  3. Magnetic properties of Sc{sub x}Ti{sub 1-x}Fe{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Kessler, M. [Lab. de Cristallographie, CNRS, 38 - Grenoble (France); Deportes, J. [Lab. Louis Neel, CNRS, 38 - Grenoble (France); Ouladdiaf, B. [Institut Laue-Langevin, 38 - Grenoble (France); Sayetat, F. [Lab. de Cristallographie, CNRS, 38 - Grenoble (France)

    1995-02-09

    The magnetic properties and their thermal dependences of Sc{sub 0.1}Ti{sub 0.9}Fe{sub 1.96}, Sc{sub 0.1}Ti{sub 0.9}Fe{sub 2} and Sc{sub 0.1}Ti{sub 0.9}Fe{sub 2.04} are compared with those of TiFe{sub 2}. The substitution changes the iron-iron distances. Consequently, the Fe atoms on the 6h site show in addition to the antiferromagnetic component a small ferromagnetic one, and a weak magnetic moment appears on the 2a site. ((orig.)).

  4. Assembly of a supercrystal (SC) of the CMS endcap electromagnetic calorimeter

    CERN Multimedia

    J. Williams et al., RAL

    2004-01-01

    The first three pictures show the insertion of the first three rows of crystals into the supercrystal SC03 on Jan. 2004 and the completion of the SC endstops. Fig. 4 shows a complete supercrystal and Fig. 5 its components (alveolar, interface plate, housing, optical fibre, insert, crystal and VPT, endstop). A set of 25 inserts is shown in Fig. 6, while Fig. 7 shows housing, interface plates and inserts. Finally, a SC rear view showing the Vacum Phototriode (VPT) wires through the inserts can be seen in Fig. 8. Fig. 9 and 10 show two supercrystals under test on Dee F and R, respectively.

  5. AlScN thin film based surface acoustic wave devices with enhanced microfluidic performance

    OpenAIRE

    Wang, Wenbo; Fu, Yong Qing; Chen, Jinju; Xuan, Weipeng; Chen, Jinkai; Mayrhofer, Paul; Duan, Pengfei; Bittner, Elmar; Luo, Jikui

    2016-01-01

    This paper reports the characterization of scandium aluminum nitride (Al1−x Sc x N, x  =  27%) films and discusses surface acoustic wave (SAW) devices based on them. Both AlScN and AlN films were deposited on silicon by sputtering and possessed columnar microstructures with (0 0 0 2) crystal orientation. The AlScN/Si SAW devices showed improved electromechanical coupling coefficients (K 2, ~2%) compared with pure AlN films (

  6. Experimental Study on Temperature Behavior of SC Structures under Pure Bending

    International Nuclear Information System (INIS)

    Ham, K. W.; Lee, K. J.; Park, D. S.; Jeon, J. H.

    2006-01-01

    SC(Steel plate Concrete) module method uses steel plate instead of reinforcing bar and mold in existing RC structure. Steel plate modules are fabricated in advance, installed and poured with concrete in construction field, so construction period is remarkably shortened by SC module technique. In case of existence of temperature gap between internal and external structure surface such as spent fuel storage pool, thermal stress is taken place and as a result of it, structural strength is deteriorated. In this study, we designed three test specimens and several tests with or without temperature heating were conducted to evaluate temperature behavior of SC structures under pure bending loading condition

  7. Transparency and radiation hardness of Cherenkov crystals NaBi(WO4)2:Sc

    International Nuclear Information System (INIS)

    Nefedov, V.A.; Zadneprovski, B.I.; Devitsin, E.G.; Kozlov, V.A.; Potashov, S.Yu.; Terkulov, A.

    2001-01-01

    The effects of doping the Cherenkov crystal NaBi(WO 4 ) 2 with Sc ions on the optical properties and radiation hardness of this crystal have been studied. The radiation hardness of NaBi(WO 4 ) 2 :Sc is about 3 times higher than that of undoped NaBi(WO 4 ) 2 . Analytical estimations give the increase of the number of Cherenkov photons by a factor of 1.3, which leads to an improvement of the energy resolution of a calorimeter based on NaBi(WO 4 ) 2 :Sc crystals compared with undoped NaBi(WO 4 ) 2 of approximately 15%

  8. AAZTA: an ideal chelating agent for the development of {sup 44}Sc PET imaging agents

    Energy Technology Data Exchange (ETDEWEB)

    Nagy, Gabor; Szikra, Dezso; Trencsenyi, Gyoergy [Scanomed Ltd., Debrecen (Hungary); University of Debrecen, Medical Imaging Clinic (Hungary); Fekete, Aniko [University of Debrecen, Medical Imaging Clinic (Hungary); Garai, Ildiko [Scanomed Ltd., Debrecen (Hungary); Giani, Arianna M.; Negri, Roberto [Dipartimento di Scienze del Farmaco, Universita del Piemonte Orientale, Novara (Italy); Masciocchi, Norberto [Dipartimento di Scienza e Alta Tecnologia e To.Sca.Lab, Universita degli Studi dell' Insubria, Como (Italy); Maiocchi, Alessandro; Uggeri, Fulvio [Bracco Imaging spa, Bracco Research Centre, Colleretto Giacosa (Italy); Toth, Imre [Department of Inorganic and Analytical Chemistry, University of Debrecen (Hungary); Aime, Silvio [Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Centro di Imaging Molecolare e Preclinico, Universita degli Studi di Torino (Italy); Giovenzana, Giovanni B. [Dipartimento di Scienze del Farmaco, Universita del Piemonte Orientale, Novara (Italy); CAGE Chemicals srl, Novara (Italy); Baranyai, Zsolt [Bracco Imaging spa, Bracco Research Centre, Colleretto Giacosa (Italy); Department of Inorganic and Analytical Chemistry, University of Debrecen (Hungary)

    2017-02-13

    Unprecedented fast and efficient complexation of Sc{sup III} was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)] amino-6-methylperhydro-1,4-d iazepine) under mild experimental conditions. The robustness of the {sup 44}Sc(AAZTA){sup -} chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.

    Science.gov (United States)

    Huang, Emina H; Hynes, Mark J; Zhang, Tao; Ginestier, Christophe; Dontu, Gabriela; Appelman, Henry; Fields, Jeremy Z; Wicha, Max S; Boman, Bruce M

    2009-04-15

    Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identification and isolation of SC from normal and malignant colon. Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as a possible marker for identifying colonic SC and for tracking them during cancer progression. Immunostaining showed that ALDH1(+) cells are sparse and limited to the normal crypt bottom, where SCs reside. During progression from normal epithelium to mutant (APC) epithelium to adenoma, ALDH1(+) cells increased in number and became distributed farther up the crypt. CD133(+) and CD44(+) cells, which are more numerous and broadly distributed in normal crypts, showed similar changes during tumorigenesis. Flow cytometric isolation of cancer cells based on enzymatic activity of ALDH (Aldefluor assay) and implantation of these cells in nonobese diabetic-severe combined immunodeficient mice (a) generated xenograft tumors (Aldefluor(-) cells did not), (b) generated them after implanting as few as 25 cells, and (c) generated them dose dependently. Further isolation of cancer cells using a second marker (CD44(+) or CD133(+) serially) only modestly increased enrichment based on tumor-initiating ability. Thus, ALDH1 seems to be a specific marker for identifying, isolating, and tracking human colonic SC during CRC development. These findings also support our original hypothesis, derived previously from mathematical modeling of crypt dynamics, that progressive colonic SC overpopulation occurs during colon tumorigenesis and drives CRC development.

  10. Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

    Science.gov (United States)

    Huang, Emina H.; Hynes, Mark J.; Zhang, Tao; Ginestier, Christophe; Dontu, Gabriela; Appelman, Henry; Fields, Jeremy Z.; Wicha, Max S.; Boman, Bruce M.

    2009-01-01

    Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identification and isolation of SC from normal and malignant colon. Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as a possible marker for identifying colonic SC and for tracking them during cancer progression. Immunostaining showed that ALDH1+ cells are sparse and limited to the normal crypt bottom, where SCs reside. During progression from normal epithelium to mutant (APC) epithelium to adenoma, ALDH1+ cells increased in number and became distributed farther up the crypt. CD133+ and CD44+ cells, which are more numerous and broadly distributed in normal crypts, showed similar changes during tumorigenesis. Flow cytometric isolation of cancer cells based on enzymatic activity of ALDH (Aldefluor assay) and implantation of these cells in nonobese diabetic–severe combined immunodeficient mice (a) generated xenograft tumors (Aldefluor− cells did not), (b) generated them after implanting as few as 25 cells, and (c) generated them dose dependently. Further isolation of cancer cells using a second marker (CD44+ or CD133+ serially) only modestly increased enrichment based on tumor-initiating ability. Thus, ALDH1 seems to be a specific marker for identifying, isolating, and tracking human colonic SC during CRC development. These findings also support our original hypothesis, derived previously from mathematical modeling of crypt dynamics, that progressive colonic SC overpopulation occurs during colon tumorigenesis and drives CRC development. PMID:19336570

  11. Assessment of strain-specific PrP(Sc elongation rates revealed a transformation of PrP(Sc properties during protein misfolding cyclic amplification.

    Directory of Open Access Journals (Sweden)

    Nuria Gonzalez-Montalban

    Full Text Available Prion replication is believed to consist of two components, a growth or elongation of infectious isoform of the prion protein (PrP(Sc particles and their fragmentation, a process that provides new replication centers. The current study introduced an experimental approach that employs Protein Misfolding Cyclic Amplification with beads (PMCAb and relies on a series of kinetic experiments for assessing elongation rates of PrP(Sc particles. Four prion strains including two strains with short incubation times to disease (263K and Hyper and two strains with very long incubation times (SSLOW and LOTSS were tested. The elongation rate of brain-derived PrP(Sc was found to be strain-specific. Strains with short incubation times had higher rates than strains with long incubation times. Surprisingly, the strain-specific elongation rates increased substantially for all four strains after they were subjected to six rounds of serial PMCAb. In parallel to an increase in elongation rates, the percentages of diglycosylated PrP glycoforms increased in PMCAb-derived PrP(Sc comparing to those of brain-derived PrP(Sc. These results suggest that PMCAb selects the same molecular features regardless of strain initial characteristics and that convergent evolution of PrP(Sc properties occurred during in vitro amplification. These results are consistent with the hypothesis that each prion strain is comprised of a variety of conformers or 'quasi-species' and that change in the prion replication environment gives selective advantage to those conformers that replicate most effectively under specific environment.

  12. In situ powder X-ray diffraction, synthesis, and magnetic properties of the defect zircon structure ScVO(4-x).

    Science.gov (United States)

    Shafi, Shahid P; Kotyk, Matthew W; Cranswick, Lachlan M D; Michaelis, Vladimir K; Kroeker, Scott; Bieringer, Mario

    2009-11-16

    We report the formation pathway of ScVO(4) zircon from ScVO(3) bixbyite with emphasis on the synthesis and stability of the novel intermediate defect zircon phase ScVO(4-x) (0.0 situ powder X-ray diffraction. The oxidation of ScVO(3) to ScVO(4) involves two intermediates of composition ScVO(3.5+y) (0.00 diffraction, neutron diffraction, and bulk magnetic susceptibility data as well as (45)Sc and (51)V solid state NMR spectroscopy. ScVO(4-x) can only be obtained by oxidation of ScVO(3) or ScVO(3.5+y) while the reduction of ScVO(4) does not yield the novel defect structure. Mechanistic insights into the oxidative formation of ScVO(4) via the defect structure are presented.

  13. Training conquers multitasking costs by dividing task representations in the frontoparietal-subcortical system.

    Science.gov (United States)

    Garner, K G; Dux, Paul E

    2015-11-17

    Negotiating the information-rich sensory world often requires the concurrent management of multiple tasks. Despite this requirement, humans are thought to be poor at multitasking because of the processing limitations of frontoparietal and subcortical (FP-SC) brain regions. Although training is known to improve multitasking performance, it is unknown how the FP-SC system functionally changes to support improved multitasking. To address this question, we characterized the FP-SC changes that predict training outcomes using an individual differences approach. Participants (n = 100) performed single and multiple tasks in pre- and posttraining magnetic resonance imaging (fMRI) sessions interspersed by either a multitasking or an active-control training regimen. Multivoxel pattern analyses (MVPA) revealed that training induced multitasking improvements were predicted by divergence in the FP-SC blood oxygen level-dependent (BOLD) response patterns to the trained tasks. Importantly, this finding was only observed for participants who completed training on the component (single) tasks and their combination (multitask) and not for the control group. Therefore, the FP-SC system supports multitasking behavior by segregating constituent task representations.

  14. Language Training: French Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch General and Professional French Courses The next session will take place from 26 April to 02 July 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 April to 02 July 2004. This course is designed for people with a good level of s...

  15. Language Training: French Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch General and Professional French Courses The next session will take place from 26 April to 02 July 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 April to 02 July 2004. This course is designed for people with a good level...

  16. Figure 1. Prediction of ScHP1 transmembrane domains I to XIV. (http ...

    Indian Academy of Sciences (India)

    Figure 2. Comparison of the ScHP1 amino acid sequence with H. +. -PPase from other species. The conserved domains GGG,. DVGADLVGKVE, DNVGDNVGD, EYYT and GNTTAA were found in the sequence alignment (shown in red boxes).

  17. Figure 1. Prediction of ScHP1 transmembrane domains I to XIV. (http ...

    Indian Academy of Sciences (India)

    embnet.org/software/TMPRED_form.html). Page 2. Figure 2. Comparison of the ScHP1 amino acid sequence with H. +. -PPase from other species. The conserved domains GGG,. DVGADLVGKVE, DNVGDNVGD, EYYT and GNTTAA were found ...

  18. DiSC aitab käitumist parandada / Ain Kivesti

    Index Scriptorium Estoniae

    Kivesti, Ain

    2008-01-01

    DiSC testi abil on võimalik saada ülevaade personaalsetest käitumishoiakutest ning vastavalt olukorrale on võimalik harjumuspärast reageerimisstiili radikaalselt muuta. Kommenteerivad Jorma Sarv ja Paavo Pilv

  19. Promising electron mobility and high thermal conductivity in Sc2CT2 (T = F, OH) MXenes

    Science.gov (United States)

    Zha, Xian-Hu; Zhou, Jie; Zhou, Yuhong; Huang, Qing; He, Jian; Francisco, Joseph S.; Luo, Kan; Du, Shiyu

    2016-03-01

    MXenes, the new 2D transition metal carbides and nitrides, have recently attracted extensive attention due to their diverse applications and excellent performances. However, the thermal and electrical properties of most MXene materials are yet to be studied. In this work, we investigate the electrical and thermal properties of semiconducting Sc2CT2 (T = F, OH) MXenes using first-principles calculations. Both of the Sc2CT2 (T = F, OH) MXenes are determined to show excellent carrier mobilities. The electron mobility in the Sc2CF2 MXene is found to be strongly anisotropic at room temperature, with values of 5.03 × 103 and 1.07 × 103 cm2 V-1 s-1 in the zigzag and armchair directions, respectively. The predicted electron mobility in the zigzag direction of the Sc2CF2 is nearly four-fold that in the armchair direction of the promising semiconductor phosphorene. In contrast to Sc2CF2, Sc2C(OH)2 presents approximately isotropic electron mobility. The values at room temperature in the zigzag and armchair directions are calculated as 2.06 × 103 cm2 V-1 s-1 and 2.19 × 103 cm2 V-1 s-1, respectively. In regard to the thermal properties, the thermal conductivities of the Sc2CT2 (T = F, OH) MXenes have been determined. The predicted values are higher than those of most metals and semiconducting low-dimensional materials, such as monolayer MoS2 and phosphorene. In particular, the room-temperature thermal conductivity along the Sc2CF2 armchair direction has been determined to be as high as 472 W m-1 K-1 based on a flake length of 5 μm, which is even higher than that of the best traditional conductor silver. The corresponding value in the zigzag direction of Sc2CF2 is calculated to be 178 W m-1 K-1. The thermal conductivity in Sc2C(OH)2 is less anisotropic and lower compared to that in Sc2CF2. The room-temperature value in the armchair (zigzag) direction is determined to be 173 W m-1 K-1 (107 W m-1 K-1). Based on their excellent electron mobilities and high thermal

  20. Curriculum (Study Programme) for the M.Sc., Medialogy, at Aalborg University in Copenhagen

    DEFF Research Database (Denmark)

    Serafin, Stefania; Nordahl, Rolf; Lavatino, Salvatore

    2004-01-01

    Defining and describing the education, M.Sc., Medialogy. The curriculum (Study Programme) describes semesters, themes, projectunits, courses and contents of the eduation. offered at Aalborg University in Copenhagen....

  1. Early Stages of Precipitation Process in Al-(Mn-)Sc-Zr Alloy Characterized by Positron Annihilation

    KAUST Repository

    Vlach, Martin

    2015-01-29

    Thermal effects on the precipitation stages in as-cast Al-0.70 at. pct Mn-0.15 at. pct Sc-0.05 at. pct Zr alloy were studied. The role of lattice defects was elucidated by positron annihilation spectroscopy (lifetime and coincidence Doppler broadening) enabling investigation of solutes clustering at the atomic scale. This technique has never been used in the Al-Sc- and/or Al-Zr-based alloys so far. Studies by positron annihilation were combined with resistometry, hardness measurements, and microstructure observations. Positrons trapped at defects are preferentially annihilated by Sc electrons. Lifetime of trapped positrons indicates that Sc atoms segregate at dislocations. Maximum fraction of positrons annihilated by Sc electrons occurring at 453 K (180 °C) suggests that clustering of Sc bound with vacancies takes place. It is followed by peak of this fraction at 573 K (300 °C). A rise of the contribution of trapped positrons annihilated by Zr electrons starting at 513 K (240 °C) and attaining maximum also at 573 K (300 °C) confirms that Zr participates in precipitation of the Al3Sc particles already at these temperatures. The pronounced hardening at 573 K (300 °C) has its nature in the precipitation of the Al3Sc particles with a Zr-rich shell. The contribution of trapped positrons annihilated by Mn electrons was found to be negligible. © 2015, The Minerals, Metals & Materials Society and ASM International.

  2. Magnetic dipole moment of the doubly closed-shell plus one proton nucleus $^{49}$Sc

    CERN Multimedia

    Gaulard, C V; Walters, W; Nishimura, K; Muto, S; Bingham, C R

    It is proposed to measure the magnetic moment of $^{49}$Sc by the Nuclear Magnetic Resonance on Oriented Nuclei (NMR-ON) method using the NICOLE on-line nuclear orientation facility. $^{49}$Sc is the neutron rich, doubly closed-shell, nucleus $^{48}$Ca plus one proton. Results will be used to deduce the effective g-factors in the $^{48}$Ca region with reference to nuclear structure and meson exchange current effects.

  3. CMS ECAL Endcap (EE) Dee Assembly - SC mounting on Dee 1

    CERN Multimedia

    Cockerill, D

    2007-01-01

    Protection panels on back of Dee 1, Completion of SC mounting, 03/10/2007: Completion of SC mounting (aart from the inner 3-2-1)on the first quadrant of Dee 1 and subsequent survey. 22-28/08/2007: The first supercrystals on Dee1, Dee1 in 867 with the first column of SCs ready for mounting, Dee1 with its protection panels over the laser monitoring fibre system

  4. Evaluating School Obesity-related Policies Using Surveillance Tools: Lessons from The ScOPE Study

    OpenAIRE

    Nanney, Marilyn S.; Nelson, Toben F.; Kubik, Martha Y.; Coulter, Sara; Davey, Cynthia S.; MacLehose, Richard; Rode, Peter

    2014-01-01

    The evidence evaluating the association between school obestiy prevention policies and student weight is mixed. The lack of consistent findings may result, in part, from limited evaluation approaches. The goal of this paper is to demonstrate the use of surveillance data to address methodological gaps and opportunities in the school policy evaluation literature using lessons from the School Obesity-related Policy Evaluation (ScOPE) study. The ScOPE study uses a repeated, cross-sectional study ...

  5. Selection of scFvs specific for the HepG2 cell line using ribosome ...

    Indian Academy of Sciences (India)

    In order to isolate specific scFvs, recognizing HepG2 negative selection on a normal hepatocyte line WRL-68 was carried out before three rounds of positive selection on HepG2. After three rounds of panning, cell enzyme-linked immunosorbent assay (ELISA) showed that one of the scFvs had high affinity for the HepG2 cell ...

  6. Strength and Conditioning Training by the Danish National Handball Team Before an Olympic Tournament

    DEFF Research Database (Denmark)

    Kvorning, Thue; Hansen, Mikkel R B; Jensen, Kurt

    2017-01-01

    preparation to improve performance and reduce incidence of injuries. The purpose of this case report was to describe and analyze the strength and conditioning (S&C) training performed by the Danish national handball team before the Beijing Olympic Games. Eight weeks of S&C was divided into 5 weeks emphasizing......Kvorning, T, Hansen, MRB, and Jensen, K. Strength and conditioning training by the Danish national handball team before an Olympic tournament. J Strength Cond Res 31(7): 1759-1765, 2017-The physical demands imposed on national team handball teams during the Olympics imply significant physical......-body muscle strength. This case report may be used as a handy script for handball teams preparing for competition. Detailed and periodized S&C training programs for 8 weeks are provided and can be used by teams ranging from moderately to highly trained....

  7. Sc-Decorated Porous Graphene for High-Capacity Hydrogen Storage: First-Principles Calculations

    Directory of Open Access Journals (Sweden)

    Yuhong Chen

    2017-08-01

    Full Text Available The generalized gradient approximation (GGA function based on density functional theory is adopted to investigate the optimized geometrical structure, electron structure and hydrogen storage performance of Sc modified porous graphene (PG. It is found that the carbon ring center is the most stable adsorbed position for a single Sc atom on PG, and the maximum number of adsorbed H2 molecules is four with the average adsorption energy of −0.429 eV/H2. By adding a second Sc atom on the other side of the system, the hydrogen storage capacity of the system can be improved effectively. Two Sc atoms located on opposite sides of the PG carbon ring center hole is the most suitable hydrogen storage structure, and the hydrogen storage capacity reach a maximum 9.09 wt % at the average adsorption energy of −0.296 eV/H2. The adsorption of H2 molecules in the PG system is mainly attributed to orbital hybridization among H, Sc, and C atoms, and Coulomb attraction between negatively charged H2 molecules and positively charged Sc atoms.

  8. Antagonistic factors control the unproductive splicing of SC35 terminal intron.

    Science.gov (United States)

    Dreumont, Natacha; Hardy, Sara; Behm-Ansmant, Isabelle; Kister, Liliane; Branlant, Christiane; Stévenin, James; Bourgeois, Cyril F

    2010-03-01

    Alternative splicing is regulated in part by variations in the relative concentrations of a variety of factors, including serine/arginine-rich (SR) proteins. The SR protein SC35 self-regulates its expression by stimulating unproductive splicing events in the 3' untranslated region of its own pre-mRNA. Using various minigene constructs containing the terminal retained intron and flanking exons, we identified in the highly conserved last exon a number of exonic splicing enhancer elements responding specifically to SC35, and showed an inverse correlation between affinity of SC35 and enhancer strength. The enhancer region, which is included in a long stem loop, also contains repressor elements, and is recognized by other RNA-binding proteins, notably hnRNP H protein and TAR DNA binding protein (TDP-43). Finally, in vitro and in cellulo experiments indicated that hnRNP H and TDP-43 antagonize the binding of SC35 to the terminal exon and specifically repress the use of SC35 terminal 3' splice site. Our study provides new information about the molecular mechanisms of SC35-mediated splicing activation. It also highlights the existence of a complex network of self- and cross-regulatory mechanisms between splicing regulators, which controls their homeostasis and offers many ways of modulating their concentration in response to the cellular environment.

  9. Reduction of the thermal conductivity of the thermoelectric material ScN by Nb alloying

    DEFF Research Database (Denmark)

    Tureson, Nina; Van Nong, Ngo; Fournier, Daniele

    2017-01-01

    ) orientation. The crystal structure, morphology, thermal conductivity, and thermoelectric and electrical properties were investigated. The ScN reference film exhibited a Seebeck coefficient of −45 μV/K and a power factor of 6 × 10−4 W/m K2 at 750 K. Estimated from room temperature Hall measurements, all...... samples exhibit a high carrier density of the order of 1021 cm−3. Inclusion of heavy transition metals into ScN enables the reduction in thermal conductivity by an increase in phonon scattering. The Nb inserted ScN thin films exhibited a thermal conductivity lower than the value of the ScN reference (10.......5 W m−1 K−1) down to a minimum value of 2.2 Wm−1 K−1. Insertion of Nb into ScN thus resulted in a reduction in thermal conductivity by a factor of ∼5 due to the mass contrast in ScN, which increases the phonon scattering in the material....

  10. SC-228 Inclusion of DAA Warning Alert for TCAS Interoperability

    Science.gov (United States)

    Fern, Lisa

    2016-01-01

    This white paper summarizes NASA research results that have informed Special Committee 228 (SC-228) discussions and decisions regarding the inclusion of a warning-level alert within the detect and avoid (DAA) alerting structure for unmanned aircraft systems (UAS). For UAS, the removal of the pilot from onboard the aircraft has eliminated the ability of the ground-based pilot in command (PIC) to use out-the-window visual information to make judgments about a potential threat of a loss of well clear with another aircraft. As a result, the DAA traffic display will be the primary source of information that the PIC can use to execute the three primary well clear functions: 1) detect a potential loss of well clear, 2) determine a resolution maneuver, and 3) upload that maneuver to the aircraft via the ground control station (GCS). In addition, pilots are required to coordinate with air traffic control (ATC) prior to maneuvering off of their approved flight plan. In determining an appropriate resolution maneuver to avoid a loss of well clear, the PIC must decide both when and how to maneuver, and both the timeliness and the accuracy (i.e., correctness) of the maneuver are critical to reducing the likelihood and/or severity of a loss of well clear. Alerting information is one of three critical components of the DAA display, along with traffic information elements (e.g., relative heading, speed and altitude) and maneuver guidance. Alerting information and maneuver guidance, in particular, have been found to have a significant impact, both statistically and practically, on pilots' ability to avoid and minimize the severity of losses of well clear While all three display components are key to pilots performing the traffic avoidance task of remaining well clear, in general, alerting information provides crucial information about when a resolution maneuver is required while maneuver guidance assists the pilot in determining how best to maneuver. A fundamental task of the DAA

  11. The acute satellite cell response and skeletal muscle hypertrophy following resistance training.

    Directory of Open Access Journals (Sweden)

    Leeann M Bellamy

    Full Text Available The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC as a potential mediator of hypertrophy. Twenty-three males (aged 18-35 yrs participated in 16 wk of progressive, whole body resistance training, resulting in changes of 7.9±1.6% (range of -1.9-24.7% and 21.0±4.0% (range of -7.0 to 51.7% in quadriceps volume and myofibre cross-sectional area (CSA, respectively. The SC response to a single bout of resistance exercise (80% 1RM, analyzed via immunofluorescent staining resulted in an expansion of type II fibre associated SC 72 h following exercise (pre: 11.3±0.9; 72 h: 14.8±1.4 SC/type II fibre; p<0.05. Training resulted in an expansion of the SC pool associated with type I (pre: 10.7±1.1; post: 12.1±1.2 SC/type I fibre; p<0.05 and type II fibres (pre: 11.3±0.9; post: 13.0±1.2 SC/type II fibre; p<0.05. Analysis of individual SC responses revealed a correlation between the relative change in type I associated SC 24 to 72 hours following an acute bout of resistance exercise and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.566, p = 0.012 and the relative change in type II associated SC following 16 weeks of resistance training and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.493, p = 0.027. Our results suggest that the SC response to resistance exercise is related to the extent of muscular hypertrophy induced by training.

  12. Training management

    International Nuclear Information System (INIS)

    Martin, H.D.

    1986-01-01

    The following topics to be covered in this report are: Design principles for training programmes; training methods, materials and facilities; national and international organization; training assessment and documentation; relation between supplier and customer, licensing requirements and practices. (orig.)

  13. A preliminary investigation of stimulus control training for worry: effects on anxiety and insomnia.

    Science.gov (United States)

    McGowan, Sarah Kate; Behar, Evelyn

    2013-01-01

    For individuals with generalized anxiety disorder, worry becomes associated with numerous aspects of life (e.g., time of day, specific stimuli, environmental cues) and is thus under poor discriminative stimulus control (SC). In addition, excessive worry is associated with anxiety, depressed mood, and sleep difficulties. This investigation sought to provide preliminary evidence for the efficacy of SC procedures in reducing anxiety-, mood-, and sleep-related symptoms. A total of 53 participants with high trait worry were randomly assigned to receive 2 weeks of either SC training (consisting of a 30-min time- and place-restricted worry period each day) or a control condition called focused worry (FW; consisting of instructions to not avoid naturally occurring worry so that worry and anxiety would not paradoxically increase). At post-training, SC was superior to FW in producing reductions on measures of worry, anxiety, negative affect, and insomnia, but not on measures of depression or positive affect. Moreover, SC was superior to FW in producing clinically significant change on measures of worry and anxiety. Results provide preliminary support for the use of SC training techniques in larger treatment packages for individuals who experience high levels of worry.

  14. Fiber type specific response of skeletal muscle satellite cells to high-intensity resistance training in dialysis patients

    DEFF Research Database (Denmark)

    Molsted, Stig; Andersen, Jesper Løvind; Harrison, Adrian Paul

    2015-01-01

    weekly. SC and myonuclear number were determined by immunohistochemistry of vastus lateralis muscle biopsy cross-sections. Knee extension torque was tested in a dynamometer. Results. During training SCs/type I fibers increased by 15%, whereas SCs/type II fibers remained unchanged. Myonuclear content......Introduction. The aim was to investigate the effect of high-intensity resistance training on satellite cell (SC) and myonuclear number in the muscle of patients undergoing dialysis. Methods. Patients (n=21) underwent a 16-week control period, followed by 16 weeks of resistance training thrice...... of type II, but not type I, fibers increased with training. Before the control period, the SC content of type II fibers was lower than type I fibers, whereas contents were comparable when normalized to fiber area. Torque increased after training. Discussion. Increased myonuclear content of type II muscle...

  15. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in...

  16. Optimizing complex scandium-3,3 benzilidene BIS [4-hydroxycoumarin] with 46Sc radiotracer

    International Nuclear Information System (INIS)

    Khanza Aktari Dewi; Muhamad Basit Febrian; Duyeh Setiawan

    2015-01-01

    Coumarin, coumarin derivatives and coumarin complex compounds known to possess biological activities such as anticancer and antiviral. The reaction between the active compound coumarin derivatives with radioisotopes Sc-46 is expected to give a complex that will be marked for further investigation of its biological activity in purpose of drug development based on coumarin. This study aims to determine the optimum conditions in the synthesis of its complex compounds as well as the physico chemical characteristics including physical properties and radiochemical purity of the complex. 3.3 benzilidene bis [4-hydroxycoumarin] ligand has successfully synthesized by reacting 4-hydroxycoumarin with benzaldehyde. Complex solids formed instantly when the solution ScCl 3 labeled by Sc-46 with a pH of 5 is reacted with a ligand solution with a pH of 11 with the optimum ratio of Sc: ligand were 1:2 with optimum labeling percentage of 99,75 ± 0,02%. FTIR analysis of complex compounds and ligands show some shift in absorption due to the formation of complex. Melting point of ligand was 234°C whilst complex compound was not yet melted in maximum range of Fischer-Jons instrument at 300°C. The complex was white reddish coloured and well soluble in DMSO. Radiochemical purity of the complex Sc-(3,3 benzilidene bis [4-hydroxycoumarin]) 2 .2H 2 O was 91.22%. Complex compound of coumarin labeled by Sc-46 has been successfully synthesized and characterized with proposed molecular formula of Sc-(3,3 benzilidene bis [4-hydroxycoumarin]) 2 .2H 2 O. (author)

  17. Effect of lectin (ScLL on fibroblasts stimulated with LPS - an in vitro study

    Directory of Open Access Journals (Sweden)

    Manuella Verdinelli de Paula REIS

    Full Text Available Abstract: The lectin (ScLL extracted from the Synadenium carinatum plant has been evaluated as an immunomodulator in diseases such as asthma, neosporosis and leishmaniasis. However, it has not yet been evaluated in the oral cavity. This study evaluated the effect of ScLL on viability, proliferation and release of IL-10 in human gingival fibroblasts (HGF stimulated with lipopolysaccharide (LPS. HGF were stimulated with LPS 1 µg/ml and treated with ScLL in concentrations of 10, 5 and 2 µg/ml for 1 and 5 h, and evaluated by flow cytometry for viability, apoptosis (initial/advanced and necrosis. The supernatant was collected to detect release of IL-10 by ELISA. The proliferation was assessed with the BrdU assay. Positive control consisted of cells maintained in Dulbecco's Modified Eagles Medium (DMEM, and the negative control, of those kept in tap water. Data were analyzed by ANOVA and Dunnett's test (α = 0.05. No significant difference was found for ScLL concentrations regarding viability or initial and advanced apoptosis (p=0.455. All the groups, including the positive control, had a significantly lower necrosis parameter than negative control at 5 h (p < 0.001. No difference was found for proliferation among the experimental groups (p = 0.832. ScLL at 5 and 2 µg/ml resulted in a lower release of IL-10 than positive and negative controls at 5 h (p = 0.047. The results indicated that ScLL concentrations tested were not cytotoxic, and had no effect on proliferation and release of IL-10 parameters. A thorough understanding of ScLL, regarding its immunomodulatory potential, may open the door to new perspectives for dentistry.

  18. SC-Associated Electric Field Variations in the Magnetosphere and Ionospheric Convective Flows

    Science.gov (United States)

    Kim, S.-I.; Kim, K.-H.; Kwon, H.-J.; Jin, H.; Lee, E.; Jee, G.; Nishitani, N.; Hori, T.; Lester, M.; Wygant, J. R.

    2017-11-01

    We examine magnetic and electric field perturbations associated with a sudden commencement (SC), caused by an interplanetary (IP) shock passing over the Earth's magnetosphere on 16 February 2013. The SC was identified in the magnetic and electric field data measured at Time History of Events and Macroscale Interactions during Substorms (THEMIS-E; THE-E: magnetic local time (MLT) = 12.4, L = 6.3), Van Allen Probe-A (VAP-A: MLT = 3.2, L = 5.1), and Van Allen Probe-B (VAP-B: MLT = 0.2. L = 4.9) in the magnetosphere. During the SC interval, THE-E observed a dawnward-then-duskward electric (E) field perturbation around noon, while VAP-B observed a duskward E field perturbation around midnight. VAP-A observed a dawnward-then-duskward E field perturbation in the postmidnight sector, but the duration and magnitude of the dawnward E perturbation are much shorter and weaker than that at THE-E. That is, the E field signature changes with local time during the SC interval. The Super Dual Auroral Radar Network radar data indicate that the ionospheric plasma motions during the SC are mainly due to the E field variations observed in space. This indicates that the SC-associated E field in space plays a significant role in determining the dynamic variations of the ionospheric convection flow. By comparing previous SC MHD simulations and our observations, we suggest that the E field variations observed at the spacecraft are produced by magnetospheric convection flows due to deformation of the magnetosphere as the IP shock sweeps the magnetopause.

  19. Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

    Science.gov (United States)

    Pavoni, Emiliano; Flego, Michela; Dupuis, Maria Luisa; Barca, Stefano; Petronzelli, Fiorella; Anastasi, Anna Maria; D'Alessio, Valeria; Pelliccia, Angela; Vaccaro, Paola; Monteriù, Giorgia; Ascione, Alessandro; De Santis, Rita; Felici, Franco; Cianfriglia, Maurizio; Minenkova, Olga

    2006-01-01

    Background CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. Methods The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. Results The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. Conclusion The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance. PMID:16504122

  20. Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

    Directory of Open Access Journals (Sweden)

    De Santis Rita

    2006-02-01

    Full Text Available Abstract Background CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. Methods The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. Results The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. Conclusion The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance.

  1. Expression and detection of ScFvB9 and its mutant in recombinant phage antibody system.

    Science.gov (United States)

    Yang, E J; Kwak, J W; Chang, H C

    2001-01-01

    Recombinant single-chain antibody (ScFvB9) and its mutant (ScFvB9-6) were generated by using a polymerase chain reaction (PCR) from the Fab fragment of the murine monoclonal antibody (MAb) B9, MabB9 (gamma2b,kappa), which is specific for human plasma apolipoprotein (apo) B-100 of low density lipopreotein (LDL). In the recombinant phage antibody system (RPAS), the constructed ScFvB9 and ScFvB9-6 antibody genes were cloned into the pCANTAB5E phagemid vector and expressed in E. coli. The active forms of single-chain antibodies (ScFvB9 and ScFvB9-6) were produced as phage-displayed recombinant antibodies or soluble antibody forms in E. coli. The activities of ScFvB9 and ScFvB9-6 were confirmed by enzyme-linked immunosorbent assay (ELISA) and Western blotting analysis; the generated mutant ScFvB9-6 showed slightly higher antigen binding activity than native ScFvB9 as a soluble antibody in this RPAS.

  2. Re-assessment of PrP(Sc distribution in sporadic and variant CJD.

    Directory of Open Access Journals (Sweden)

    Richard Rubenstein

    Full Text Available Human prion diseases are fatal neurodegenerative disorders associated with an accumulation of PrP(Sc in the central nervous system (CNS. Of the human prion diseases, sporadic Creutzfeldt-Jakob disease (sCJD, which has no known origin, is the most common form while variant CJD (vCJD is an acquired human prion disease reported to differ from other human prion diseases in its neurological, neuropathological, and biochemical phenotype. Peripheral tissue involvement in prion disease, as judged by PrP(Sc accumulation in the tonsil, spleen, and lymph node has been reported in vCJD as well as several animal models of prion diseases. However, this distribution of PrP(Sc has not been consistently reported for sCJD. We reexamined CNS and non-CNS tissue distribution and levels of PrP(Sc in both sCJD and vCJD. Using a sensitive immunoassay, termed SOFIA, we also assessed PrP(Sc levels in human body fluids from sCJD as well as in vCJD-infected humanized transgenic mice (Tg666. Unexpectedly, the levels of PrP(Sc in non-CNS human tissues (spleens, lymph nodes, tonsils from both sCJD and vCJD did not differ significantly and, as expected, were several logs lower than in the brain. Using protein misfolding cyclic amplification (PMCA followed by SOFIA, PrP(Sc was detected in cerebrospinal fluid (CSF, but not in urine or blood, in sCJD patients. In addition, using PMCA and SOFIA, we demonstrated that blood from vCJD-infected Tg666 mice showing clinical disease contained prion disease-associated seeding activity although the data was not statistically significant likely due to the limited number of samples examined. These studies provide a comparison of PrP(Sc in sCJD vs. vCJD as well as analysis of body fluids. Further, these studies also provide circumstantial evidence that in human prion diseases, as in the animal prion diseases, a direct comparison and intraspecies correlation cannot be made between the levels of PrP(Sc and infectivity.

  3. pPKCδ activates SC35 splicing factor during H9c2 myoblastic differentiation.

    Science.gov (United States)

    Zara, Susi; Falconi, Mirella; Rapino, Monica; Zago, Michela; Orsini, Giovanna; Mazzotti, Giovanni; Cataldi, Amelia; Teti, Gabriella

    2011-01-01

    Although Protein Kinase C (PKC) isoforms' role in the neonatal and adult cardiac tissue development and ageing has been widely described "in vivo", the interaction of such enzymes with specific nuclear substrates needs to be investigated. The aim of our research has been the study of the expression, localization and interaction with the splicing factor SC35 of PKC isoforms (α, δ, ε, ζ) and their potential role in modulating the transcription machinery. H9c2 cells induced to myoblast differentiation in the presence of 1% Horse Serum (HS) have represented our experimental model. The expression of PKC isoforms, their distribution and interaction with SC35 have been evaluated by western blotting, co-immunoprecipitation and double gold immunolabeling for transmission and scanning electron microscopy. Our results show PKCδ as the most expressed isoform in differentiated cells. Surprisingly, the distribution of PKCδ and SC35 does not show any significant modification between 10%FBS and 1%HS treated samples and no co-localization is observed. Moreover the interaction between the phosphorylated form of PKCδ (pPKCδ) and SC35 increases, is distributed and co-localizes within the nucleus of differentiated H9c2. These data represent reasonable evidence of pPKCδ mediated SC35 splicing factor activation, suggesting its direct effect on transcription via interaction with the transcription machinery. Furthermore, this co-localization represents a crucial event resulting in downstream changes in transcription of components which determine the morphological modifications related to cardiomyoblast differentiated phenotype.

  4. Semisolid slurry of 7A04 aluminum alloy prepared by electromagnetic stirring and Sc, Zr additions

    Directory of Open Access Journals (Sweden)

    Jun-wen Zhao

    2017-05-01

    Full Text Available Slurry preparation is one of the most critical steps for semisolid casting, and its primary goal is to prepare slurry with uniformly distributed fine globules. In this work, electromagnetic stirring (EMS and the addition of Sc and Zr elements were used to prepare semisolid slurry of 7A04 aluminum alloy in a large diameter slurry maker. The effects of different treatments on the microstructure, composition and their radial homogeneity were investigated. The results show that, compared to the slurry without any treatment, large volume slurry with finer and more uniform microstructure can be obtained when treated by EMS, Sc, or Zr additions individually. EMS is more competent in the microstructural and chemical homogenization of the slurry while Sc and Zr additions are more excellent in its microstructural refinement. The combined treatment of EMS, Sc and Zr produces premium 7A04 aluminum alloy slurry with uniformly distributed fine α-Al globules and composition. The interaction mechanism between EMS and Sc and Zr additions was also discussed.

  5. Hardness and microstructural variation of Al-Mg-Mn-Sc-Zr alloy.

    Science.gov (United States)

    Ikeshita, Sumiha; Strodahs, Ansis; Saghi, Zineb; Yamada, Kazuhiro; Burdet, Pierre; Hata, Satoshi; Ikeda, Ken-Ichi; Midgley, Paul A; Kaneko, Kenji

    2016-03-01

    Variations of Vickers hardness were observed in Al-Mg-Mn alloy and Al-Mg-Mn-Sc-Zr alloy at different ageing times, ranging from a peak value of 81.2 HV at 54 ks down to 67.4 HV at 360 ks, below the initial hardness value, 71.8 HV at 0 ks for the case of Al-Mg-Mn-Sc-Zr alloy. Microstructures of samples at each ageing stage were examined carefully by transmission electron microscopes (TEMs) both in two-dimensions and three-dimensions. The presence of different types, densities, and sizes of particles were observed dispersed spherical Al3Sc1-xZrx and also block-shaped Al3Sc precipitates growing along Al with facets {100} and {110} of the precipitates. TEM analysis both in two-dimensions and three-dimensions, performed on various samples, confirmed the direct correlation between the hardness and the density of Al3Sc. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Spectrophotometric determination of Sc in eriochrome cyanine R(chrome azurol S) - phosphatidyl choline system

    International Nuclear Information System (INIS)

    Xu, Y.; Chen, X.; Hu, Z.

    1987-01-01

    Eriochrome cyanine R(chrome azurol S) is used as a color reagent to determine Sc in the presence of phosphatidyl choline, eta = 3.7 * 10 4 (4.5 * 10 4 ). This method has been connected to extraction separation to determine Sc in the presence of rare earth elements, and good results have been obtained. Phosphatidyl choline(PC) is a biochemical reagent, which can be used as a surfactant. It has been reported that chrome azurol S(CAS) can be used to determine Be in the presence of PC but it has not been reported that eriochrome cyanine R(ECR) and CAS can been used to determine Sc in the presence of PC. This paper has put forward a method by which Sc can be determined. ECR (CAS) has been used as a color reagent and PC as a surfactant. Conditional experiments have been made and this method has been connected to extraction separation. Tributyl phosphate (TBP) extracts Sc from rare earth elements to make a determination and good results have been obtained

  7. Influence of Sc on microstructure and mechanical properties of Al-Si-Mg-Cu-Zr alloy

    Science.gov (United States)

    Li, Yukun; Du, Xiaodong; Zhang, Ya; Zhang, Zhen; Fu, Junwei; Zhou, Shi'ang; Wu, Yucheng

    2018-02-01

    In the present study, the effects of Mg, Cu, Sc and Zr combined additions on the microstructure and mechanical properties of hypoeutectic Al-Si cast alloy were systematically investigated. Characterization techniques such as optical microscopy (OM), scanning electron microscope (SEM), energy dispersive spectrometer (EDS), electron back-scatter diffraction (EBSD), atomic force microscopy (AFM), transmission electron microscope (TEM), Brinell hardness tester and universal testing machine were employed to analyze the microstructure and mechanical properties. The results showed that Sc served as modifier on the microstructure of Al-3Si-0.45Mg-0.45Cu-0.2Zr alloys, including modification of eutectic Si and grains. Extraordinarily, grain refinement was found to be related to the primary particles, which exhibited a close orientation to matrix. After T6 heat treatment, the grain structures were composed of nano-scaled secondary Al3(Sc, Zr) precipitates and spherical eutectic Si. Combined with T6 heat treatment, the highest hardness, yield strength, ultimate tensile strength and elongation were achieved in 0.56 wt.% Sc-modified alloy. Interestingly, the strength and ductility had a similar tendency. This paper demonstrated that combined additions of Mg, Cu, Sc and Zr could significantly improve the microstructure and performance of the hypoeutectic Al-Si cast alloy.

  8. Conductivity ageing studies on 1M10ScSZ (M4+=Ce, Hf)

    DEFF Research Database (Denmark)

    Omar, Shobit; Bin Najib, Waqas; Bonanos, Nikolaos

    2011-01-01

    The long-term conductivity stability is tested on zirconia based electrolyte materials for solid oxide fuel cell applications. The ageing studies have been performed on the samples of ZrO2 co-doped with 10mol% of Sc2O3 and 1mol% MO2, where M = Ce or Hf (denoted respectively 1Ce10ScSZ and 1Hf10Sc......SZ) in oxidising and reducing atmospheres, at 600°C for 3000h. At 600°C, these compositions show initial conductivity of around 9–12mS∙cm−1 in air. After 3000h of ageing, no phase transitions are observed in any of the samples. For the first 1000h, the degradation rate is higher than in the subsequent 2000h......; thereafter, conductivity degrades linearly with time for all samples. In air, the loss in the conductivity is lower than in reducing conditions. The 1Ce10ScSZ shows the highest degradation rate of 3.8%/1000h in wet H2/N2 after the first 1000h of ageing. A colour change of the 1Ce10ScSZ sample from white...

  9. AlScN thin film based surface acoustic wave devices with enhanced microfluidic performance

    International Nuclear Information System (INIS)

    Wang, W B; Xuan, W P; Chen, J K; Wang, X Z; Luo, J K; Fu, Y Q; Chen, J J; Duan, P F; Mayrhofer, P; Bittner, A; Schmid, U

    2016-01-01

    This paper reports the characterization of scandium aluminum nitride (Al 1−xS c xN , x   =  27%) films and discusses surface acoustic wave (SAW) devices based on them. Both AlScN and AlN films were deposited on silicon by sputtering and possessed columnar microstructures with (0 0 0 2) crystal orientation. The AlScN/Si SAW devices showed improved electromechanical coupling coefficients ( K 2 , ∼2%) compared with pure AlN films (<0.5%). The performance of the two types of devices was also investigated and compared, using acoustofluidics as an example. The AlScN/Si SAW devices achieved much lower threshold powers for the acoustic streaming and pumping of liquid droplets, and the acoustic streaming and pumping velocities were 2  ×  and 3  ×  those of the AlN/Si SAW devices, respectively. Mechanical characterization showed that the Young’s modulus and hardness of the AlN film decreased significantly when Sc was doped, and this was responsible for the decreased acoustic velocity and resonant frequency, and the increased temperature coefficient of frequency, of the AlScN SAW devices. (paper)

  10. Fast conversion of scFv to Fab antibodies using type IIs restriction enzymes.

    Science.gov (United States)

    Sanmark, Hanna; Huovinen, Tuomas; Matikka, Tero; Pettersson, Tiina; Lahti, Maria; Lamminmäki, Urpo

    2015-11-01

    Single chain variable fragment (scFv) antibody libraries are widely used for developing novel bioaffinity reagents, although Fab or IgG molecules are the preferred antibody formats in many final applications. Therefore, rapid conversion methods for combining multiple DNA fragments are needed to attach constant domains to the scFv derived variable domains. In this study we describe a fast and easy cloning method for the conversion of single framework scFv fragments to Fab fragments using type IIS restriction enzymes. All cloning steps excluding plating of the Fab transformants can be done in 96 well plates and the procedure can be completed in one working day. The concept was tested by converting 69 scFv clones into Fab format on 96 well plates, which resulted in 93% success rate. The method is particularly useful as a high-throughput tool for the conversion of the chosen scFv clones into Fab molecules in order to analyze them as early as possible, as the conversion can significantly affect the binding properties of the chosen clones. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Detection of Metallothionein in Javanese Medaka (Oryzias javanicus, Using a scFv-Immobilized Protein Chip

    Directory of Open Access Journals (Sweden)

    Euiyeon Lee

    2018-04-01

    Full Text Available Environmental pollution by various industrial chemicals and biological agents poses serious risks to human health. Especially, marine contamination by potentially toxic elements (PTEs has become a global concern in recent years. Many efforts have been undertaken to monitor the PTE contamination of the aquatic environment. However, there are few approaches available to assess the PTE exposure of aquatic organisms. In this research, we developed a strategy to evaluate the heavy metal exposure of marine organisms, by measuring the expression levels of metallothionein protein derived from Oryzias javanicus (OjaMT. OjaMT is a biomarker of heavy metal exposure because the expression level increases upon heavy metal exposure. The developed assay is based on a real-time, label-free surface plasmon resonance (SPR measurement. Anti-OjaMT antibody and anti-OjaMT single-chain fragment of variable region (scFv were used as detection probes. Two types of SPR sensor chips were fabricated, by immobilizing antibody or Cys3-tagged scFv (scFv-Cys3 in a controlled orientation and were tested for in situ label-free OjaMT detection. Compared to the antibody-presenting sensor chips, the scFv-presenting sensor chips showed improved performance, displaying enhanced sensitivity and enabling semi-quantitative detection. The portable SPR system combined with scFv-immobilized sensor chips is expected to provide an excellent point-of-care testing system that can monitor target biomarkers in real time.

  12. Language Training - French Training

    CERN Multimedia

    HR Department

    2008-01-01

    General and Professional French Courses The next session will take place from 26 January to 3rd April 2009. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Writing Professional Documents in French The next session will take place from 26 January to 3rd April 2009. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  13. Language Training - French Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional French Courses The next session will take place from 26 January to 3rd April 2009. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Writing Professional Documents in French The next session will take place from 26 January to 3rd April 2009. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  14. First-principles study of the nucleation and stability of ordered precipitates in ternary Al-Sc-Li alloys

    International Nuclear Information System (INIS)

    Mao, Z.; Chen, W.; Seidman, D.N.; Wolverton, C.

    2011-01-01

    First-principles density functional calculations are used to study the nucleation and stability of L1 2 -ordered precipitates in Al-Sc-Li alloys. For dilute Al alloys, there are three possible ordered L1 2 precipitates: Al 3 Sc, Al 3 Li and an Al 3 Sc/Al 3 Li core/shell structure. To calculate the nucleation behavior, information about bulk thermodynamics (both static total energies and vibrational free energies), interfacial energetics and coherency strain is required. The study finds the following: (1) the coherency strain energies for forming coherent interfaces between Al/Al 3 Sc, Al/Al 3 Li and Al 3 Sc/Al 3 Li are relatively small, owing to the small atomic size mismatches in these systems; (2) the sublattice site preferences of Sc and Li are calculated, and it is demonstrated that Sc and Li share the same sublattice sites in both Al 3 Sc(L1 2 ) and Al 3 Li(L1 2 ), in agreement with recent experimental results; (3) the calculated solubilities of Sc and Li in α-Al alloys are in good agreement with experimental values and, for Sc, agree well with prior first-principles results; (4) the interfacial energies for Al/Al 3 Sc, Al/Al 3 Li and Al 3 Sc/Al 3 Li for (1 0 0), (1 1 0) and (1 1 1) interfaces are calculated: the values of the Al/Al 3 Sc interfacial energies are significantly larger than those of the Al/Al 3 Li and Al 3 Sc/Al 3 Li interfaces; (5) combining the bulk and interfacial energies yields the nucleation barriers and critical radii for Al 3 Sc and Al 3 Li precipitates; and (6) the energetic stability of the Al 3 Sc/Al 3 Li core/shell structure is compared with individual Al 3 Sc and Al 3 Li nuclei, and the range of precipitate sizes for which the core/shell structure is energetically favored is determined quantitatively.

  15. X-ray spectra, chemical bonding, and electron structure of ScM2Si2 (M = Fe, Co, Ni)

    International Nuclear Information System (INIS)

    Shcherba, I.D.; Kotur, B.Ya.

    1990-01-01

    In a study of the interaction of the components in the ternary systems Sc-M-Si (where M is a 3d transition metal) it was established that there are compounds of the empirical formula ScM 2 Si 2 (M = Fe, Co, Ni). They crystallize in two structural types, HfFe 2 Si 2 (the compound ScFe 2 Si 2 ) and CeGa 2 Al 2 (ScCo 2 Si 2 and ScNi 2 Si 2 ) (ref. 1), leading to different coordination environment of the atoms in the structures of the compounds. With the aim of investigating the electron structure and the type ofin these compounds, they authors made a systematic x-ray spectral investigation with simultaneous analysis of the crystal structures of ScM 2 Si 2

  16. Comparison of Response between RC and SC Containment Structures Subjected to Aircraft Impact

    International Nuclear Information System (INIS)

    Shin, Sang Shup; Choi, In Kil; Park, Tae Hyo

    2012-01-01

    Since the aircraft terror to the World Trade Center (WTC) on September 11, 2001, an aircraft impact problem has been increasingly interested. The possibilities of aircraft impacts against nuclear power plants are one of important category. To date, the impact load of the analysis on aircraft impacts has been applied to target structures in local areas by using the impact force-time history function of Riera. However, Riera forcing function is not recommended at the expectation of unreasonable damage or perforation to target structures. The numerical analysis of rc and sc containment structures subjected to aircraft impact is performed by using the AUTODYN-3D. It is carried out the four different types for RC and SC structures. Thus, in this study, the different behaviors of containment structures and the safety of SC structure are expected

  17. Comparison of Response between RC and SC Containment Structures Subjected to Aircraft Impact

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Sang Shup; Choi, In Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Tae Hyo [Hanyang University, Seoul (Korea, Republic of)

    2012-05-15

    Since the aircraft terror to the World Trade Center (WTC) on September 11, 2001, an aircraft impact problem has been increasingly interested. The possibilities of aircraft impacts against nuclear power plants are one of important category. To date, the impact load of the analysis on aircraft impacts has been applied to target structures in local areas by using the impact force-time history function of Riera. However, Riera forcing function is not recommended at the expectation of unreasonable damage or perforation to target structures. The numerical analysis of rc and sc containment structures subjected to aircraft impact is performed by using the AUTODYN-3D. It is carried out the four different types for RC and SC structures. Thus, in this study, the different behaviors of containment structures and the safety of SC structure are expected

  18. Electronic structure of cubic ScF3 from first-principles calculations

    International Nuclear Information System (INIS)

    Bocharov, D.; Piskunov, S.; Kuz'min, A.; Purans, J.; Zhguns, P.

    2016-01-01

    The ground state properties of cubic scandium trifluoride (ScF 3 ) perovskite were studied using first-principles calculations. The electronic structure of ScF 3 was determined by linear combination of atomic orbital (LCAO) and plane wave projector augmented-wave (PAW) methods using modified hybrid exchange-correlation functionals within the density functional theory (DFT). The comprehensive comparison of the results obtained by two methods is presented. Both methods allowed us to reproduce the lattice constant found experimentally in ScF 3 at low temperatures and to predict its electronic structure in good agreement with known experimental valence-band photoelectron and F 1s x-ray absorption spectra.

  19. A comprehensive framework for optimising the effects of inverse logistics practices in SC sustainability

    Directory of Open Access Journals (Sweden)

    Cristina López Vargas

    2017-06-01

    Full Text Available With growing sustainability concern in mind, firms seek to implement reverse logistic systems in their operations. However, if these practices were not properly implemented, they would be costly and even ineffective. In order to guide company efforts, the present study provide a comprehensive framework based on two dimensions. On one hand, it suits a reverse logistic management model stage-by-stage. On the other hand, the framework brings together concrete measures to optimize SC sustainability from three perspectives: operative, economical and environmental. The proposed framework thus allow to balance reverse logistic practices and SC sustainability. Furthermore, we validated it by analysing six real case in different industries. Findings highlight how reverse logistic activities may improve each SC sustainability dimension.

  20. Synthesis and crystal structure of the first Sc-Nb-O-N phases

    Energy Technology Data Exchange (ETDEWEB)

    Orthmann, Steven; Lerch, Martin [Institut fuer Chemie, Technische Universitaet Berlin (Germany)

    2017-11-17

    Synthesis of phase-pure materials in the system Sc-Nb-O-N is challenging. In this contribution we report on the preparation of the first scandium niobium oxide nitrides via reaction of water-saturated gaseous ammonia or an ammonia-oxygen mixture with amorphous scandium niobium oxides. Two new phases were obtained: rutile-type ScNb{sub 4}O{sub 7}N{sub 3}, which crystallizes in space group P4{sub 2}/mnm, and an anion-deficient fluorite-type Sc{sub 2}Nb(O,N,⬜){sub 6} phase crystallizing in space group Fm anti 3m. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  1. Synthesis and Isolation of the Titanium-Scandium Endohedral Fullerenes-Sc2 TiC@Ih -C80 , Sc2 TiC@D5h -C80 and Sc2 TiC2 @Ih -C80 : Metal Size Tuning of the Ti(IV) /Ti(III) Redox Potentials.

    Science.gov (United States)

    Junghans, Katrin; Ghiassi, Kamran B; Samoylova, Nataliya A; Deng, Qingming; Rosenkranz, Marco; Olmstead, Marilyn M; Balch, Alan L; Popov, Alexey A

    2016-09-05

    The formation of endohedral metallofullerenes (EMFs) in an electric arc is reported for the mixed-metal Sc-Ti system utilizing methane as a reactive gas. Comparison of these results with those from the Sc/CH4 and Ti/CH4 systems as well as syntheses without methane revealed a strong mutual influence of all key components on the product distribution. Whereas a methane atmosphere alone suppresses the formation of empty cage fullerenes, the Ti/CH4 system forms mainly empty cage fullerenes. In contrast, the main fullerene products in the Sc/CH4 system are Sc4 C2 @C80 (the most abundant EMF from this synthesis), Sc3 C2 @C80 , isomers of Sc2 C2 @C82 , and the family Sc2 C2 n (2 n=74, 76, 82, 86, 90, etc.), as well as Sc3 CH@C80 . The Sc-Ti/CH4 system produces the mixed-metal Sc2 TiC@C2 n (2 n=68, 78, 80) and Sc2 TiC2 @C2 n (2 n=80) clusterfullerene families. The molecular structures of the new, transition-metal-containing endohedral fullerenes, Sc2 TiC@Ih -C80 , Sc2 TiC@D5h -C80 , and Sc2 TiC2 @Ih -C80 , were characterized by NMR spectroscopy. The structure of Sc2 TiC@Ih -C80 was also determined by single-crystal X-ray diffraction, which demonstrated the presence of a short Ti=C double bond. Both Sc2 TiC- and Sc2 TiC2 -containing clusterfullerenes have Ti-localized LUMOs. Encapsulation of the redox-active Ti ion inside the fullerene cage enables analysis of the cluster-cage strain in the endohedral fullerenes through electrochemical measurements. © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  2. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease

    Directory of Open Access Journals (Sweden)

    Rayra Pereira Santiago

    2017-01-01

    Full Text Available Reference values for cerebral blood flow velocity (CBFV in hemoglobin SC disease (HbSC have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC count, hemoglobin, hematocrit, and direct bilirubin (DB, yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW and nitric oxide metabolite (NOx concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.

  3. Conversion of scFv peptide-binding specificity for crystal chaperone development

    Energy Technology Data Exchange (ETDEWEB)

    Pai, Jennifer C.; Culver, Jeffrey A.; Drury, Jason E.; Motani, Rakesh S.; Lieberman, Raquel L.; Maynard, Jennifer A. (GIT); (UMM); (Texas)

    2012-02-07

    In spite of advances in protein expression and purification over the last decade, many proteins remain recalcitrant to structure determination by X-ray crystallography. One emerging tactic to obtain high-quality protein crystals for structure determination, particularly in the case of membrane proteins, involves co-crystallization with a protein-specific antibody fragment. Here, we report the development of new recombinant single-chain antibody fragments (scFv) capable of binding a specific epitope that can be introduced into internal loops of client proteins. The previously crystallized hexa-histidine-specific 3D5 scFv antibody was modified in the complementary determining region and by random mutagenesis, in conjunction with phage display, to yield scFvs with new biochemical characteristics and binding specificity. Selected variants include those specific for the hexa-histidine peptide with increased expression, solubility (up to 16.6 mg/ml) and sub-micromolar affinity, and those with new specificity for the EE hexa-peptide (EYMPME) and nanomolar affinity. Complexes of one such chaperone with model proteins harboring either an internal or a terminal EE tag were isolated by gel filtration. The 3.1 {angstrom} resolution structure of this chaperone reveals a binding surface complementary to the EE peptide and a {approx}52 {angstrom} channel in the crystal lattice. Notably, in spite of 85% sequence identity, and nearly identical crystallization conditions, the engineered scFv crystallizes in a different space group than the parent 3D5 scFv, and utilizes two new crystal contacts. These engineered scFvs represent a new class of chaperones that may eliminate the need for de novo identification of candidate chaperones from large antibody libraries.

  4. Assessment of the GLLB-SC potential for solid-state properties and attempts for improvement

    Science.gov (United States)

    Tran, Fabien; Ehsan, Sohaib; Blaha, Peter

    2018-02-01

    Based on the work of Gritsenko et al. (GLLB) [Phys. Rev. A 51, 1944 (1995), 10.1103/PhysRevA.51.1944], the method of Kuisma et al. [Phys. Rev. B 82, 115106 (2010), 10.1103/PhysRevB.82.115106] to calculate the band gap in solids was shown to be much more accurate than the common local density approximation (LDA) and generalized gradient approximation (GGA). The main feature of the GLLB-SC potential (SC stands for solid and correlation) is to lead to a nonzero derivative discontinuity that can be conveniently calculated and then added to the Kohn-Sham band gap for a comparison with the experimental band gap. In this work, a thorough comparison of GLLB-SC with other methods, e.g., the modified Becke-Johnson (mBJ) potential [Tran and Blaha, Phys. Rev. Lett. 102, 226401 (2009), 10.1103/PhysRevLett.102.226401], for electronic, magnetic, and density-related properties is presented. It is shown that for the band gap, GLLB-SC does not perform as well as mBJ for systems with a small band gap and strongly correlated systems, but is on average of similar accuracy as hybrid functionals. The results on itinerant metals indicate that GLLB-SC overestimates significantly the magnetic moment (much more than mBJ does), but leads to excellent results for the electric field gradient, for which mBJ is in general not recommended. In the aim of improving the results, variants of the GLLB-SC potential are also tested.

  5. Isolation and characterization of anti c-met single chain fragment variable (scFv) antibodies.

    Science.gov (United States)

    Qamsari, Elmira Safaie; Sharifzadeh, Zahra; Bagheri, Salman; Riazi-Rad, Farhad; Younesi, Vahid; Abolhassani, Mohsen; Ghaderi, Sepideh Safaei; Baradaran, Behzad; Somi, Mohammad Hossein; Yousefi, Mehdi

    2017-12-01

    The receptor tyrosine kinase (RTK) Met is the cell surface receptor for hepatocyte growth factor (HGF) involved in invasive growth programs during embryogenesis and tumorgenesis. There is compelling evidence suggesting important roles for c-Met in colorectal cancer proliferation, migration, invasion, angiogenesis, and survival. Hence, a molecular inhibitor of an extracellular domain of c-Met receptor that blocks c-Met-cell surface interactions could be of great thera-peutic importance. In an attempt to develop molecular inhibitors of c-Met, single chain variable fragment (scFv) phage display libraries Tomlinson I + J against a specific synthetic oligopeptide from the extracellular domain of c-Met receptor were screened; selected scFv were then characterized using various immune techniques. Three c-Met specific scFv (ES1, ES2, and ES3) were selected following five rounds of panning procedures. The scFv showed specific binding to c-Met receptor, and significantly inhibited proliferation responses of a human colorectal carcinoma cell line (HCT-116). Moreover, anti- apoptotic effects of selected scFv antibodies on the HCT-116 cell line were also evaluated using Annexin V/PI assays. The results demonstrated rates of apoptotic cell death of 46.0, 25.5, and 37.8% among these cells were induced by use of ES1, ES2, and ES3, respectively. The results demonstrated ability to successfully isolate/char-acterize specific c-Met scFv that could ultimately have a great therapeutic potential in immuno-therapies against (colorectal) cancers.

  6. Generation and characterization of a novel recombinant scFv antibody specific for Campylobacter jejuni.

    Science.gov (United States)

    Nzuma, Ruramayi M; Liu, Fuquan; Grant, Irene R

    2018-04-07

    Campylobacter jejuni is a leading cause of foodborne illness worldwide, mainly due to consumption and handling of contaminated raw chicken. Rapid detection methods for C. jejuni are vital for monitoring contamination levels in chicken products and reducing human Campylobacteriosis cases. The 'gold standard' culture-based method of Campylobacter detection takes 3-5 days and is too slow to permit effective intervention. Immuno-based methods are faster, but usually necessitate use of animals or hybridoma technology to produce antibodies; making them difficult and expensive to produce. Here, we report the generation and characterization of recombinant single-chain variable fragment (scFv) antibodies specific for C. jejuni cells, and evaluation of one scFv antibody for an immunomagnetic separation-quantitative PCR (IMS-qPCR) method to rapidly, sensitively, and specifically detect low numbers of C. jejuni. An scFv antibody phage-display library was constructed using spleen mRNA derived from a rabbit immunized with gamma-irradiated C. jejuni cells. This library was screened by surface biopanning against C. jejuni whole cells. Enriched clones were analyzed by enzyme-linked immunosorbent assay (ELISA). Two scFv antibodies that strongly and specifically recognized C. jejuni cell were expressed in Escherichia coli. Western blot analysis showed that one antibody, scFv80, was expressed as a soluble protein and retained its specific and strong binding to C. jejuni cells. This recombinant monoclonal scFv antibody was purified and used to covalently coat paramagnetic beads to be used for IMS-qPCR. The IMS-qPCR method was able to specifically and sensitively detect C. jejuni in mixed cultures within 3 h.

  7. Readying Community Water Fluoridation Advocates through Training, Surveillance, and Empowerment.

    Science.gov (United States)

    Veschusio, C; Jones, M K; Mercer, J; Martin, A B

    2017-11-10

    This paper describes the Community Water Fluoridation Advocacy Training Project that was designed to develop networks of community water fluoridation advocates in rural communities. The South Carolina (SC) Department of Health and Environmental Control Division of Oral Health staff and the SC Dental Association were responsible for developing and facilitating the training sessions for key policy influencers, which included medical and dental providers, early childhood educators, and water system operators and managers. Findings from the post-training survey indicate that participants increased their knowledge and skills to discuss the impact of water fluoridation on the dental health of community residents. Participants identified a need for online access to water fluoridation education and advocacy materials. Dental public health competencies illustrated: communication and collaboration with groups and individuals, and advocate, implement and evaluate public health policy, legislation and regulations. Copyright© 2017 Dennis Barber Ltd.

  8. ScBO/sub 3/: Cr-A room temperature near-infrared tunable laser

    International Nuclear Information System (INIS)

    Lai, S.T.; Chai, B.H.T.; Long, M.; Morris, R.C.

    1986-01-01

    The authors report the first room temperature tunable laser in a borate single crystal. A tuning range of 787-892 nm has been demonstrated in a ScBO/sub 3/:Cr laser. The laser loss is estimated to be 1.3 percent/cm from our preliminary laser results. Spectroscopic measurements indicate that the material is clear of absorption loss in the lasing spectral region, and the relative fluorescence efficiency for the entire Cr absorption band in the visible region is nearly unit. ScBO/sub 3/:Cr holds promise as a high efficiency near-infrared tunable laser

  9. Electrical characterization of high-pressure reactive sputtered ScOx films on silicon

    International Nuclear Information System (INIS)

    Castan, H.; Duenas, S.; Gomez, A.; Garcia, H.; Bailon, L.; Feijoo, P.C.; Toledano-Luque, M.; Prado, A. del; San Andres, E.; Lucia, M.L.

    2011-01-01

    Al/ScO x /SiN x /n-Si and Al/ScO x /SiO x /n-Si metal-insulator-semiconductor capacitors have been electrically characterized. Scandium oxide was grown by high-pressure sputtering on different substrates to study the dielectric/insulator interface quality. The substrates were silicon nitride and native silicon oxide. The use of a silicon nitride interfacial layer between the silicon substrate and the scandium oxide layer improves interface quality, as interfacial state density and defect density inside the insulator are decreased.

  10. Axial compression behavior and partial composite action of SC walls in safety-related nuclear facilities

    Science.gov (United States)

    Zhang, Kai

    Steel-plate reinforced concrete (SC) composite walls typically consist of thick concrete walls with two exterior steel faceplates. The concrete core is sandwiched between the two steel faceplates, and the faceplates are attached to the concrete core using shear connectors, for example, ASTM A108 steel headed shear studs. The shear connectors and the concrete infill enhance the stability of the steel faceplates, and the faceplates serve as permanent formwork for concrete placement. SC composite walls were first introduced in the 1980's in Japan for nuclear power plant (NPP) structures. They are used in the new generation of nuclear power plants (GIII+) and being considered for small modular reactors (SMR) due to their structural efficiency, economy, safety, and construction speed. Steel faceplates can potentially undergo local buckling at certain locations of NPP structures where compressive forces are significant. The steel faceplates are usually thin (0.25 to 1.50 inches in Customary units, or 6.5 to 38 mm in SI units) to maintain economical and constructional efficiency, the geometric imperfections and locked-in stresses induced during construction make them more vulnerable to local buckling. Accidental thermal loading may also reduce the compressive strength and exacerbate the local buckling potential of SC composite walls. This dissertation presents the results from experimental and numerical investigations of the compressive behavior of SC composite walls at ambient and elevated temperatures. The results are used to establish a slenderness limit to prevent local buckling before yielding of the steel faceplates and to develop a design approach for calculating the compressive strength of SC composite walls with non-slender and slender steel faceplates at ambient and elevated temperatures. Composite action in SC walls is achieved by the embedment of shear connectors into the concrete core. The strength and stiffness of shear connectors govern the level of

  11. Pressure-induced structural transformations in the molybdate Sc-2(MoO4)(3)

    DEFF Research Database (Denmark)

    Paraguassu, W.; Maczka, M.; Filho, A. G. Sonza

    2004-01-01

    High pressure Raman scattering and x-ray diffraction studies of the molybdate Sc-2(MoO4)(3) are presented. A sequence of changing symmetry effects is observed through two structural phase transitions ending up with an amorphous state. The observed two structural phase transformations are reversible....... The crystal to amorphous transition is irreversible. Our results point out that the amorphization process in Sc-2(MoO4)(3) may be due to a kinetic hindrance of a phase transition rather than due to chemical decomposition effects as have been proposed to occur for some molybdates and tungstates....

  12. On measuring the UNK SC-dipole bending strength with rotating pick-up coil

    International Nuclear Information System (INIS)

    Smirnov, N.L.; Tikhov, A.V.

    1993-01-01

    The experience in measuring the SC-dipole bending strength with the spotting method shown this measurement to be the most complicated and expensive. A convenient and simple method of rotating pick-up coil, which can not provide the required accuracy, may be used for this measurement combined with NMR measurements in the dipole central part. The physical ground and description of the method are given in the paper. The analysis of the errors and measurement results of the SPDMI SC-dipoles are presented. 9 refs..; 7 figs

  13. Renormalized molecular levels in a Sc3N@C-80 molecular electronic device

    DEFF Research Database (Denmark)

    Larade, Brian; Taylor, Jeremy Philip; Zheng, Q. R.

    2001-01-01

    We address several general questions about quantum transport through molecular systems by an ab initio analysis of a scandium-nitrogen doped C-80 metallofullerene device. Charge transfer from the Sc3N is found to drastically change the current-voltage characteristics: the current through the Sc3N...... @ C-80 device is double that through a bare C-80 device. We provide strong evidence that transport in such molecular devices is mediated by molecular electronic states which have been renormalized by the device environment, such as the electrodes and external bias V-b. The renormalized molecular...

  14. Dieu et l'Homme dans le Microcosme de Maurice Scève

    OpenAIRE

    Antkowiak, Krystyna

    1990-01-01

    Poemat M. Scève'a nawiązuje poprzez swój tytuł do filozoficznej koncepcji człowieka jako mikrokosmosu, poprzez aluzje w tekście - do tradycji godności człowieka, poprzez opis stworzenia świata - do literatury heksameralnej, a poprzez wątek dramatyczny (historia człowieka od upadku po odkupienie) - do teatru religijnego (Jeu d'Adam). Ten ostatni element wydaje się najistotniejszy w poemacie Scève'a: moment, w którym Bóg mimo grzechu Adama czyni go kontynuatorem dzieła stworze...

  15. SC: A NOVEL FUZZY CRITERION FOR SOLVING ENGINEERING AND CONSTRAINED OPTIMIZATION PROBLEMS

    Directory of Open Access Journals (Sweden)

    Sergio G. De los Cobos Silva

    2017-04-01

    Full Text Available In this paper a novel fuzzy convergence system (SC and its fundamentals are presented. The model was implemented on a monoobjetive PSO algorithm with three phases: 1 Stabilization, 2 generation and breadth-first search, and 3 generation and depth-first. The system SC-PSO-3P was tested with several benchmark engineering problems and with several CEC2006 problems. The computing experience and comparison with previously reported results is presented. In some cases the results reported in the literature are improved.

  16. A symmetric derivative of the trimetallic nitride endohedral metallofullerene, Sc3N@C80.

    Science.gov (United States)

    Iezzi, Erick B; Duchamp, James C; Harich, Kim; Glass, Tom E; Lee, Hon Man; Olmstead, Marilyn M; Balch, Alan L; Dorn, Harry C

    2002-01-30

    The reaction of Sc3N@C80 with 6,7-dimethoxyisochroman-3-one (13C labeled) provides the first functionalized derivative of the trimetallic nitride template (TNT) endohedral metallofullerene family. The reaction mixture is dominated by a single 13C labeled monoadduct product that was purified by HPLC. The 13C labeled monoadduct was characterized by 1H NMR, 13C NMR, and MALDI-TOF mass spectrometry. The proposed structure for this novel symmetric monoadduct is consistent with derivatization at the [5,6] ring juncture on the Sc3N@C80 cage.

  17. Generation and Characterization of a scFv Antibody Against T3SS Needle of Vibrio parahaemolyticus.

    Science.gov (United States)

    Wang, Rongzhi; Fang, Sui; Xiang, Shuangshuang; Ling, Sumei; Yuan, Jun; Wang, Shihua

    2014-06-01

    Vibrio parahaemolyticus, a halophilic gram-negative bacterium, is a food-borne pathogen that largely inhabits marine and estuarine environments, and poses a serious threat to human and animal health all over the world. The hollow "needle" channel, a specific assemble of T3SS which exists in most of gram-negative bacteria, plays a key role in the transition of virulence effectors to host cells. In this study, needle protein VP1694 was successfully expressed and purified, and the fusion protein Trx-VP1694 was used to immunize Balb/c mice. Subsequently, a phage single-chain fragment variable antibody (scFv) library was constructed, and a specific scFv against VP1694 named scFv-FA7 was screened by phage display panning. To further identify the characters of scFv, the soluble expression vector pACYC-scFv-skp was constructed and the soluble scFv was purified by Ni(2+) affinity chromatography. ELISA analysis showed that the scFv-FA7 was specific to VP1694 antigen, and its affinity constant was 1.07 × 10(8 )L/mol. These results offer a molecular basis to prevent and cure diseases by scFv, and also provide a new strategy for further research on virulence mechanism of T3SS in V. parahaemolyticus by scFv.

  18. Effect of Recrystallization and Natural Aging on Mechanical Properties of Al-Zn-Mg-Cu-Sc Alloys

    International Nuclear Information System (INIS)

    Yu, Min Kyu; Hong, Soon Hyung; Kwon, Oh Yeol; Lee, Yong Yeon

    2015-01-01

    In this study, the recrystallization volume fraction of the Al-Zn-Mg-Cu-Sc alloy after solid solution heat treatment varied with different temperatures (445℃ - 465℃). The highest elongation of the Al-Zn-Mg-Cu-Sc alloy was obtained at 465℃. Further, the hardness and strength of the solid solution heat treated Al-Zn-Mg-Cu-Sc alloy increased at room temperature due to G.P zone precipitates. The results confirmed that we can obtain advanced mechanical properties for the Al-Zn-Mg-Cu-Sc alloy from solid solution heat treatment and natural aging.

  19. The acute satellite cell response and skeletal muscle hypertrophy following resistance training.

    Science.gov (United States)

    Bellamy, Leeann M; Joanisse, Sophie; Grubb, Amanda; Mitchell, Cameron J; McKay, Bryon R; Phillips, Stuart M; Baker, Steven; Parise, Gianni

    2014-01-01

    The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy. Twenty-three males (aged 18-35 yrs) participated in 16 wk of progressive, whole body resistance training, resulting in changes of 7.9±1.6% (range of -1.9-24.7%) and 21.0±4.0% (range of -7.0 to 51.7%) in quadriceps volume and myofibre cross-sectional area (CSA), respectively. The SC response to a single bout of resistance exercise (80% 1RM), analyzed via immunofluorescent staining resulted in an expansion of type II fibre associated SC 72 h following exercise (pre: 11.3±0.9; 72 h: 14.8±1.4 SC/type II fibre; pchange in type I associated SC 24 to 72 hours following an acute bout of resistance exercise and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.566, p = 0.012) and the relative change in type II associated SC following 16 weeks of resistance training and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.493, p = 0.027). Our results suggest that the SC response to resistance exercise is related to the extent of muscular hypertrophy induced by training.

  20. Musical training induces functional and structural auditory-motor network plasticity in young adults.

    Science.gov (United States)

    Li, Qiongling; Wang, Xuetong; Wang, Shaoyi; Xie, Yongqi; Li, Xinwei; Xie, Yachao; Li, Shuyu

    2018-02-05

    Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory and sensorimotor networks after long-term musical training remain largely uninvestigated. Here, we compared the structural connectivity (SC) and resting-state functional connectivity (rs-FC) within and between the two networks in 29 novice healthy young adults before and after musical training (piano) with those of another 27 novice participants who were evaluated longitudinally but with no intervention. In addition, a correlation analysis was performed between the changes in FC or SC with practice time in the training group. As expected, participants in the training group showed increased FC within the sensorimotor network and increased FC and SC of the auditory-motor network after musical training. Interestingly, we further found that the changes in FC within the sensorimotor network and SC of the auditory-motor network were positively correlated with practice time. Our results indicate that musical training could induce enhanced local interaction and global integration between musical performance-related regions, which provides insights into the mechanism of brain plasticity in young adults. © 2018 Wiley Periodicals, Inc.

  1. Gallium-containing Heusler phases ScRh{sub 2}Ga, ScPd{sub 2}Ga, TmRh{sub 2}Ga and LuRh{sub 2}Ga. Magnetic and solid state NMR-spectroscopic characterization

    Energy Technology Data Exchange (ETDEWEB)

    Heletta, Lukas; Seidel, Stefan; Poettgen, Rainer [Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie; Benndorf, Christopher [Leipzig Univ. (Germany). Inst. fuer Mineralogie, Kristallographie und Materialwissenschaften; Eckert, Hellmut [Muenster Univ. (Germany). Inst. fuer Physikalische Chemie; Sao Paulo Univ., Sao Carlos (Brazil). Inst. of Physics

    2017-10-01

    The gallium-containing Heusler phases ScRh{sub 2}Ga, ScPd{sub 2}Ga, TmRh{sub 2}Ga and LuRh{sub 2}Ga have been synthesized by arc-melting of the elements followed by different annealing sequences to improve phase purity. The samples have been studied by powder X-ray diffraction. The structures of Lu{sub 0.97}Rh{sub 2}Ga{sub 1.03} (Fm3m, a=632.94(5) pm, wR2=0.0590, 46 F{sup 2} values, seven variables) and Sc{sub 0.88}Rh{sub 2}Ga{sub 1.12} (a=618.91(4) pm, wR2=0.0284, 44 F{sup 2} values, six variables) have been refined from single crystal X-ray diffractometer data. Both gallides show structural disorder through Lu/Ga and Sc/Ga mixing. Temperature dependent magnetic susceptibility measurements showed Pauli paramagnetism for ScRh{sub 2}Ga, ScPd{sub 2}Ga, and LuRh{sub 2}Ga and Curie-Weiss paramagnetism for TmRh{sub 2}Ga. {sup 45}Sc and {sup 71}Ga solid state MAS NMR spectroscopic investigations of the Sc containing compounds confirmed the site mixing effects typically observed for Heusler phases. The data indicate that the effect of mixed Sc/Ga occupancy is significantly stronger in ScRh{sub 2}Ga than in ScPd{sub 2}Ga.

  2. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For further information, please contact Mr. Liptow, tel. 72957. Date and timetable will be fixed when there are sufficient participants enrolled. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 langua...

  3. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    La prochaine session se déroulera du 04 octobre 2004 au 11 février 2005 (interruption de 3 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web : http://cern.ch/Training Vous pouvez aussi contacter M. Liptow, tél. 72957. General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants ...

  4. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For further information, please contact Mr. Liptow, tel. 72957. Date and timetable will be fixed when there are sufficient participants enrolled. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 languag...

  5. Effect of High-Intensity Training in Normobaric Hypoxia on Thoroughbred Skeletal Muscle

    Directory of Open Access Journals (Sweden)

    Hiroshi Nagahisa

    2016-01-01

    Full Text Available Hypoxic training is believed to increase endurance capacity in association with hypoxia inducible factor-1α (HIF-1α, a modulator of vascular endothelial growth factor-A (VEGF-A, and to influence activation of satellite cells (SCs. However, the effect of hypoxic training on SC activation and its relation to angiogenesis has not been thoroughly investigated. Eight Thoroughbred horses were subjected to normoxic (FIO2 = 21% or hypoxic (FIO2 = 15% training for 3 days/week (100%  V˙O2max for 4 weeks. Incremental exercise tests (IET were conducted on a treadmill under normoxia and the maximal oxygen consumption (V˙O2max and running distance were measured before and after each training session. Muscle biopsy samples were obtained from the gluteus medius muscle at 6 scheduled times before, during, and one week after IET for immunohistochemical analysis and real-time RT-PCR analysis. Running distance and V˙O2max, measured during IET, increased significantly after hypoxic training compared with normoxic training. Capillary density and mRNA expression related to SC activation (e.g., myogenin and hepatocyte growth factor and angiogenesis (VEGF-A increased only after hypoxic training. These results suggest that increases in mRNA expression after training enhance and prolong SC activation and angiogenesis and that nitric oxide plays an important role in these hypoxia-induced training effects.

  6. Differential dynamics of splicing factor SC35 during the cell cycle

    Indian Academy of Sciences (India)

    Srinivas

    Pre-mRNA splicing factors are enriched in nuclear domains termed interchromatin granule clusters or nuclear speckles. During mitosis, nuclear ... and mitotic cells. In HeLa cells expressing green fluorescent protein (GFP)-SC35, this was localized in speckles during ... mitotic cells was determined with respect to markers for.

  7. 76 FR 54703 - Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC

    Science.gov (United States)

    2011-09-02

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The... Beach, South Carolina during the Myrtle Beach Triathlon. The Myrtle Beach Triathlon, which is comprised...

  8. 76 FR 37700 - Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC

    Science.gov (United States)

    2011-06-28

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking... Waterway in Myrtle Beach, South Carolina during the Myrtle Beach Triathlon. The Myrtle Beach Triathlon...

  9. 77 FR 14321 - Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC

    Science.gov (United States)

    2012-03-09

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking... Waterway in Myrtle Beach, South Carolina during the Myrtle Beach Triathlon. The Myrtle Beach Triathlon...

  10. Spatial Frequency Scheduling for Uplink SC-FDMA based Linearly Precoded LTE Multiuser MIMO Systems

    DEFF Research Database (Denmark)

    Lin, Zihuai; Xiao, Pei; Sørensen, Troels Bundgaard

    2010-01-01

    This paper investigates the performance of the 3GPP Long Term Evolution (LTE) uplink Single Carrier (SC) Frequency Division Multiple Access (FDMA) based linearly precoded multiuserMultiple InputMultiple Output (MIMO) systems with frequency domain packet scheduling. A mathematical expression...

  11. Effect of Agri-SC as a soil conditioner on runoff, soil loss and crust ...

    African Journals Online (AJOL)

    xp1

    2011-10-10

    Oct 10, 2011 ... Figure 1. The relationships between Agri-SC application doses to runoff in the experiment. Table 3. Correlation coefficients of experimental results. Parameter. Dose. R1. SL1. CS. R2. SL2. Doses Pearson correlation. 1.000. Sig. (2-tailed). N. 15. R1. Pearson correlation. -0.905**. 1.000. Sig. (2-tailed). 0.000.

  12. A low-voltage SC cyclic D/A converter using matrix algorithm

    OpenAIRE

    船越, 一徳; 松本, 寛樹

    2007-01-01

    In this paper, a low-voltage switched-capacitor(SC) cyclic D/A converter using matrix algorithm is proposed which consists of a switch, capacitor, MOSFET and op-amp In PSpice simulation, resolution of about 8 bits was confirmed.

  13. Dynamics of self-directed learning in M.Sc. nursing students: A qualitative research.

    Science.gov (United States)

    Shirazi, Fatemeh; Sharif, Farkhondeh; Molazem, Zahra; Alborzi, Mahboobeh

    2017-01-01

    Working in the complex and ever changing healthcare settings forces the nurses and nursing students to be equipped with lifelong learning skills. One of the lifelong learning skills is self-directed learning. This study aimed to explore the M.Sc. nursing students' self-directed learning activities. A qualitative design using conventional content analysis approach was used in this study. Semi-structured interviews were conducted with twelve Iranian M.Sc. nursing students who were selected using purposive sampling. Data analysis indicated that the M.Sc. nursing students performed different activities in their self-directed learning. These activities were categorized into four main themes and ten subthemes. The main themes were "sensory perceptions", "knowledge construction", "problem-centered orientation", and "interaction with others". According to the findings, the M.Sc. nursing students performed different intellectual and experiential self-directed activities for promoting their learning. Besides, the students' perseverance and inquisitiveness played an important role in their self-directed learning in the challenging clinical environments.

  14. Thermography of semi-transparent materials by a FLIR ThermaCAM SC3000 infrared camera

    NARCIS (Netherlands)

    Van der Tempel, L.

    2011-01-01

    An acceptance test for thermography of semi-transparent materials by a FLIR ThermaCAM SC3000 infrared camera with 8.0 µm low-wavelength-pass filter has been developed and performed on polycarbonate, PEN, quartz, Corning 1737 glass, G427 cone glas, G443 screen glass, Schott Zerodur, silicon and a

  15. 33 CFR 165.708 - Safety/Security Zone; Charleston Harbor and Cooper River, Charleston, SC.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety/Security Zone; Charleston... GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS... Guard District § 165.708 Safety/Security Zone; Charleston Harbor and Cooper River, Charleston, SC. (a...

  16. The SC3 hydrophobin self-assembles into a membrane with distinct mass transfer properties

    NARCIS (Netherlands)

    Wang, [No Value; Shi, FX; Wosten, HAB; Hektor, H; Poolman, B; Robillard, GT; Wang, X.; Shi, Fuxin

    Hydrophobins are a class of small proteins that fulfill a wide spectrum of functions in fungal growth and development. They do so by self-assembling into an amphipathic membrane at hydrophilic-hydrophobic interfaces. The SC3 hydrophobin of Schizophyllum commune is the best-studied hydrophobin. It

  17. Structural changes and molecular interactions of hydrophobin SC3 in solution and on a hydrophobic surface

    NARCIS (Netherlands)

    Wang, X.; Vocht, M.L. de; Poolman, B.; Robillard, G.T.; Wang, [No Value; Jonge, J. de

    2002-01-01

    The hydrophobin SC3 belongs to a class of small proteins functioning in the growth and development of fungi. Its unique amphipathic property and remarkable surface activity make it interesting not only for biological studies but also for medical and industrial applications. Biophysical studies have

  18. Natural moisturizing factors (NMF) in the stratum corneum (SC). I. Effects of lipid extraction and soaking.

    Science.gov (United States)

    Robinson, Marisa; Visscher, Marty; Laruffa, Angela; Wickett, Randy

    2010-01-01

    Natural moisturizing factor (NMF) is essential for appropriate stratum corneum hydration, barrier homeostasis, desquamation, and plasticity. It is formed from filaggrin proteolysis to small, hygroscopic molecules including amino acids. We hypothesized that common lipid extraction and soaking in water would alter the level of NMF in the upper SC and its biophysical properties. A novel method of measuring and quantifying the amino acid components of NMF is presented. Adhesive tapes were used to collect samples of the stratum corneum (SC) and were extracted with 6mM perchloric acid for analysis by reverse-phase HPLC. HPLC results were standardized to the amount of protein removed by the tapes. An increase in NMF was found with increased SC depth. Also, the combination of extraction and soaking was found to increase NMF loss relative to control or to extraction or soaking alone. Our results indicate that common skin care practices significantly influence the water binding materials in the upper SC. The findings have implications for the evaluation and formulation of skin care products.

  19. Ratcheting rotation or speedy spinning: EPR and dynamics of Sc3C2@C80

    Czech Academy of Sciences Publication Activity Database

    Roukala, J.; Straka, Michal; Taubert, S.; Vaara, J.; Lantto, P.

    2017-01-01

    Roč. 53, č. 64 (2017), s. 8992-8995 ISSN 1359-7345 R&D Projects: GA ČR(CZ) GA17-07091S Institutional support: RVO:61388963 Keywords : endohedral metallofullerene * contrast agents * Sc3@C82 Subject RIV: CF - Physical ; Theoretical Chemistry OBOR OECD: Physical chemistry Impact factor: 6.319, year: 2016

  20. Last 3 years of the SC-ISOLDE and move to PS-Booster

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Thus in the years 1989 and 1990 a special effort was made to supply beam to as many research projects as possible, resulting in a record number of beam shifts from the ISOLDE separators. The collaboration even had to partially support the last year of SC running before the final shutdown in December 1990.

  1. Chicken scFvs with an Artificial Cysteine for Site-Directed Conjugation.

    Directory of Open Access Journals (Sweden)

    Aerin Yoon

    Full Text Available For the site-directed conjugation of chemicals and radioisotopes to the chicken-derived single-chain variable fragment (scFv, we investigated amino acid residues replaceable with cysteine. By replacing each amino acid of the 157 chicken variable region framework residues (FR, 82 residues on VH and 75 on VL with cysteine, 157 artificial cysteine mutants were generated and characterized. At least 27 residues on VL and 37 on VH could be replaced with cysteine while retaining the binding activity of the original scFv. We prepared three VL (L5, L6 and L7 and two VH (H13 and H16 mutants as scFv-Ckappa fusion proteins and showed that PEG-conjugation to the sulfhydryl group of the artificial cysteine was achievable in all five mutants. Because the charge around the cysteine residue affects the in vivo stability of thiol-maleimide conjugation, we prepared 16 charge-variant artificial cysteine mutants by replacing the flanking residues of H13 with charged amino acids and determined that the binding activity was not affected in any of the mutants except one. We prepared four charge-variant H13 artificial cysteine mutants (RCK, DCE, ECD and ECE as scFv-Ckappa fusion proteins and confirmed that the reactivity of the sulfhydryl group on cysteine is active and their binding activity is retained after the conjugation process.

  2. SC-FDE for MMF short reach optical interconnects using directly modulated 850 nm VCSELs

    DEFF Research Database (Denmark)

    Teichmann, Victor S. C.; Barreto, Andre N.; Pham, Tien Thang

    2012-01-01

    We propose the use of single-carrier frequency-domain equalization (SC-FDE) for the compensation of modal dispersion in short distance optical links using multimode fibers and 850 nm VCSELs. By post-processing of experimental data, we demonstrate, at 7.9% overhead, the error-free transmission (ov...

  3. Correlations fo Sc, rare earths and other elements in selected rock samples from Arrua-i

    International Nuclear Information System (INIS)

    Facetti, J.F.; Prats, M.

    1972-01-01

    The Sc and Eu contents in selected rocks samples from the stock of Arrua-i have been determined and correlations established with other elements and with the relative amount of some rare earths. These correlations suggest metasomatic phenomena for the formation of the rock samples

  4. Occurence and trace analysis of Sc and Y associated to natural hydroxy - phosphates

    International Nuclear Information System (INIS)

    Siqueira, N.V.M. de; Lima, W.N. de

    1982-01-01

    Occurrence and quantitative determination of Sc and Y associated to natural hydrophosphates from Pirocaua (MA,Brazil) were studied under the viewpoints of analytical chemistry and geochemistry. The analytical method (X-ray fluorescence) showed to be adequate and the geochemical survey confirmed expected situations. (Author) [pt

  5. Improving SC-FDMA performance by Turbo Equalization in UTRA LTE Uplink

    DEFF Research Database (Denmark)

    Berardinelli, Gilberto; Priyanto, Basuki Endah; Sørensen, Troels Bundgaard

    2008-01-01

    of UTRA Long Term Evolution (LTE) Uplink. The performance is evaluated for 1x2 Single Input Multiple Output (SIMO) antenna configuration in a 6 paths Typical Urban (TU-06) channel profile. For assessment purpose, the results are compared with SC-FDMA MMSE and OFDMA schemes. Simulation results show...

  6. Response of S.C.704 maize hybrid seed production to planting pattern

    African Journals Online (AJOL)

    In order to determine the best planting pattern for producing the S.C.704 hybrid seed of maize, a field experiment was conducted in 2007 at Safiabad Dezful Research Center via a complete block design with four treatments and replicates each. The treatments were: D1 (one row each of paternal and maternal lines), D2 (two ...

  7. Effect of source and seed size on yield component of corn S.C704 in ...

    African Journals Online (AJOL)

    Seed source of corn production (hybrid SC704), desirable seed size and the relationship between seed vigor and seed size on the grain yield of field corn conducted at the Agricultural Research center, Safiabad Dezful in 2008 with 3 replicates was evaluated. In this study, seed source (Khoozestan, Moghan and Khorasan) ...

  8. 78 FR 19100 - Special Local Regulations; Charleston Race Week, Charleston Harbor; Charleston, SC

    Science.gov (United States)

    2013-03-29

    ...-AA08 Special Local Regulations; Charleston Race Week, Charleston Harbor; Charleston, SC AGENCY: Coast... regulation on the waters of Charleston Harbor in Charleston, South Carolina during Charleston Race Week, a series of sailboat races. From Thursday, April 18, 2013, until Sunday, April 21, 2013, approximately 300...

  9. 77 FR 19934 - Special Local Regulations; Charleston Race Week, Charleston Harbor, Charleston, SC

    Science.gov (United States)

    2012-04-03

    ...-AA08 Special Local Regulations; Charleston Race Week, Charleston Harbor, Charleston, SC AGENCY: Coast... regulations on the waters of Charleston Harbor in Charleston, South Carolina during Charleston Race Week, a series of sailboat races. The races are scheduled to take place on Friday, April 20, 2012, through Sunday...

  10. Meta-DiSc: a software for meta-analysis of test accuracy data.

    Science.gov (United States)

    Zamora, Javier; Abraira, Victor; Muriel, Alfonso; Khan, Khalid; Coomarasamy, Arri

    2006-07-12

    Systematic reviews and meta-analyses of test accuracy studies are increasingly being recognised as central in guiding clinical practice. However, there is currently no dedicated and comprehensive software for meta-analysis of diagnostic data. In this article, we present Meta-DiSc, a Windows-based, user-friendly, freely available (for academic use) software that we have developed, piloted, and validated to perform diagnostic meta-analysis. Meta-DiSc a) allows exploration of heterogeneity, with a variety of statistics including chi-square, I-squared and Spearman correlation tests, b) implements meta-regression techniques to explore the relationships between study characteristics and accuracy estimates, c) performs statistical pooling of sensitivities, specificities, likelihood ratios and diagnostic odds ratios using fixed and random effects models, both overall and in subgroups and d) produces high quality figures, including forest plots and summary receiver operating characteristic curves that can be exported for use in manuscripts for publication. All computational algorithms have been validated through comparison with different statistical tools and published meta-analyses. Meta-DiSc has a Graphical User Interface with roll-down menus, dialog boxes, and online help facilities. Meta-DiSc is a comprehensive and dedicated test accuracy meta-analysis software. It has already been used and cited in several meta-analyses published in high-ranking journals. The software is publicly available at http://www.hrc.es/investigacion/metadisc_en.htm.

  11. Ionic conductivity of co-doped Sc2O3-ZrO2 ceramics

    DEFF Research Database (Denmark)

    Omar, Shobit; bin Najib, Waqas; Chen, Weiwu

    2012-01-01

    The oxide ionic conductivity of Sc0.18Zr0.82O1.91 doped with 0.5 mol.% of both Yb2O3 and In2O3 is evaluated at various temperatures in air. Among various co-doped compositions, In0.02Sc0.18Zr0.80O1.90 exhibits the highest grain ionic conductivity followed by Yb0.02Sc0.18Zr0.80O1.90 at 500°C....... However, it also possesses phase transformation from c- to β-phase at 475°C on cooling. In the present work, an attempt is made to completely stabilize the cphase in In0.02Sc0.18Zr0.80O1.90 by substituting 0.5 mol.% of In2O3 with Yb2O3, which can enhance the ionic conductivity in co-doped compositions....

  12. Sc and neutron-capture abundances in Galactic low- and high-alpha field halo stars

    DEFF Research Database (Denmark)

    Fishlock, Cherie K.; Yong, D.; Karakas, Amanda I.

    2017-01-01

    We determine relative abundance ratios for the neutron-capture elements Zr, La, Ce, Nd and Eu for a sample of 27 Galactic dwarf stars with -1.5 <[Fe/H] <-0.8. We also measure the iron-peak element Sc. These stars separate into three populations (low-and high-a halo and thick-disc stars) based on ...

  13. From Strategic Communication to Simply Communicate: Redefining SC in Military Communication

    Science.gov (United States)

    2011-04-10

    referred to as Psychological Operations {PSYOPS), Defense Support for Public Diplomacy (DSPD), and Coinbat Camera/Visual Information (COMCAM), into a...Operations (IO), Military Information Support Operations (MISO) fonnerly referred to as Psychological Operations (PSYOPS), Defense Support for Public...departments and key publics. Contemporary government SC-practices were converted from private sector Integrated Marketing Communication ( IMC ) models

  14. 76 FR 75450 - Safety Zone; Container Crane Relocation, Cooper and Wando Rivers, Charleston, SC

    Science.gov (United States)

    2011-12-02

    ...-AA00 Safety Zone; Container Crane Relocation, Cooper and Wando Rivers, Charleston, SC AGENCY: Coast... moving safety zone around a barge transporting two container cranes on the Cooper and Wando Rivers during... Terminal in Charleston, South Carolina. Discussion of Rule On Monday, December 5, 2011, two container...

  15. Evaluating school obesity-related policies using surveillance tools: lessons from the ScOPE study.

    Science.gov (United States)

    Nanney, Marilyn S; Nelson, Toben F; Kubik, Martha Y; Coulter, Sara; Davey, Cynthia S; MacLehose, Richard; Rode, Peter A

    2014-09-01

    The evidence evaluating the association between school obestiy prevention policies and student weight is mixed. The lack of consistent findings may result, in part, from limited evaluation approaches. The goal of this article is to demonstrate the use of surveillance data to address methodological gaps and opportunities in the school policy evaluation literature using lessons from the School Obesity-Related Policy Evaluation (ScOPE) study. The ScOPE study uses a repeated, cross-sectional study design to evaluate the association between school food and activity policies in Minnesota and behavioral and weight status of youth attending those schools. Three surveillance tools are used to accomplish study goals: Minnesota School Health Profiles (2002-2012), Minnesota Student Survey (2001-2013), and National Center for Educational Statistics. The ScOPE study takes two broad steps. First, we assemble policy data across multiple years and monitor changes over time in school characteristics and the survey instrument(s), establish external validity, and describe trends and patterns in the distribution of policies. Second, we link policy data to student data on health behaviors and weight status, assess nonresponse bias, and identify cohorts of schools. To illustrate the potential for program evaluators, the process, challenges encountered, and solutions used in the ScOPE study are presented. © 2014 Society for Public Health Education.

  16. Selection of scFvs specific for the HepG2 cell line using ribosome ...

    Indian Academy of Sciences (India)

    Madhsudhan

    was transcribed and translated in vitro using a rabbit reticulocyte lysate system. In order to isolate specific scFvs, recognizing HepG2 negative selection on a normal hepatocyte line WRL-68 was carried out before three rounds of positive selection on HepG2. After three rounds of panning, cell enzyme-linked immunosorbent ...

  17. 76 FR 25545 - Safety Zone; Blue Crab Festival Fireworks Display, Little River, Little River, SC

    Science.gov (United States)

    2011-05-05

    ...-AA00 Safety Zone; Blue Crab Festival Fireworks Display, Little River, Little River, SC AGENCY: Coast... zone on the waters of Little River in Little River, South Carolina during the Blue Crab Festival... this rule because the Coast Guard did not receive notice of the Blue Crab Festival Fireworks Display...

  18. Interval Training

    Science.gov (United States)

    Healthy Lifestyle Fitness Interval training can help you get the most out of your workout. By Mayo Clinic Staff Are you ready to shake up ... more time at the gym? Consider aerobic interval training. Once the domain of elite athletes, interval training ...

  19. Ultra-efficient PrP(Sc amplification highlights potentialities and pitfalls of PMCA technology.

    Directory of Open Access Journals (Sweden)

    Gian Mario Cosseddu

    2011-11-01

    Full Text Available In order to investigate the potential of voles to reproduce in vitro the efficiency of prion replication previously observed in vivo, we seeded protein misfolding cyclic amplification (PMCA reactions with either rodent-adapted Transmissible Spongiform Encephalopathy (TSE strains or natural TSE isolates. Vole brain homogenates were shown to be a powerful substrate for both homologous or heterologous PMCA, sustaining the efficient amplification of prions from all the prion sources tested. However, after a few serial automated PMCA (saPMCA rounds, we also observed the appearance of PK-resistant PrP(Sc in samples containing exclusively unseeded substrate (negative controls, suggesting the possible spontaneous generation of infectious prions during PMCA reactions. As we could not definitively rule out cross-contamination through a posteriori biochemical and biological analyses of de novo generated prions, we decided to replicate the experiments in a different laboratory. Under rigorous prion-free conditions, we did not observe de novo appearance of PrP(Sc in unseeded samples of M109M and I109I vole substrates, even after many consecutive rounds of saPMCA and working in different PMCA settings. Furthermore, when positive and negative samples were processed together, the appearance of spurious PrP(Sc in unseeded negative controls suggested that the most likely explanation for the appearance of de novo PrP(Sc was the occurrence of cross-contamination during saPMCA. Careful analysis of the PMCA process allowed us to identify critical points which are potentially responsible for contamination events. Appropriate technical improvements made it possible to overcome PMCA pitfalls, allowing PrP(Sc to be reliably amplified up to extremely low dilutions of infected brain homogenate without any false positive results even after many consecutive rounds. Our findings underline the potential drawback of ultrasensitive in vitro prion replication and warn on cautious

  20. Recombinant norovirus-specific scFv inhibit virus-like particle binding to cellular ligands

    Directory of Open Access Journals (Sweden)

    Hardy Michele E

    2008-01-01

    Full Text Available Abstract Background Noroviruses cause epidemic outbreaks of gastrointestinal illness in all age-groups. The rapid onset and ease of person-to-person transmission suggest that inhibitors of the initial steps of virus binding to susceptible cells have value in limiting spread and outbreak persistence. We previously generated a monoclonal antibody (mAb 54.6 that blocks binding of recombinant norovirus-like particles (VLP to Caco-2 intestinal cells and inhibits VLP-mediated hemagglutination. In this study, we engineered the antigen binding domains of mAb 54.6 into a single chain variable fragment (scFv and tested whether these scFv could function as cell binding inhibitors, similar to the parent mAb. Results The scFv54.6 construct was engineered to encode the light (VL and heavy (VH variable domains of mAb 54.6 separated by a flexible peptide linker, and this recombinant protein was expressed in Pichia pastoris. Purified scFv54.6 recognized native VLPs by immunoblot, inhibited VLP-mediated hemagglutination, and blocked VLP binding to H carbohydrate antigen expressed on the surface of a CHO cell line stably transfected to express α 1,2-fucosyltransferase. Conclusion scFv54.6 retained the functional properties of the parent mAb with respect to inhibiting norovirus particle interactions with cells. With further engineering into a form deliverable to the gut mucosa, norovirus neutralizing antibodies represent a prophylactic strategy that would be valuable in outbreak settings.

  1. A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice.

    Science.gov (United States)

    Eddy, Meghan C; Eschle, Benjamin K; Peterson, Darlene; Lauras, Nathan; Margolskee, Robert F; Delay, Eugene R

    2012-06-01

    Previously, published studies have reported mixed results regarding the role of the TRPM5 cation channel in signaling sweet taste by taste sensory cells. Some studies have reported a complete loss of sweet taste preference in TRPM5 knockout (KO) mice, whereas others have reported only a partial loss of sweet taste preference. This study reports the results of conditioned aversion studies designed to motivate wild-type (WT) and KO mice to respond to sweet substances. In conditioned taste aversion experiments, WT mice showed nearly complete LiCl-induced response suppression to sucrose and SC45647. In contrast, TRPM5 KO mice showed a much smaller conditioned aversion to either sweet substance, suggesting a compromised, but not absent, ability to detect sweet taste. A subsequent conditioned flavor aversion experiment was conducted to determine if TRPM5 KO mice were impaired in their ability to learn a conditioned aversion. In this experiment, KO and WT mice were conditioned to a mixture of SC45647 and amyl acetate (an odor cue). Although WT mice avoided both components of the stimulus mixture, they avoided SC45647 more than the odor cue. The KO mice also avoided both stimuli, but they avoided the odor component more than SC45647, suggesting that while the KO mice are capable of learning an aversion, to them the odor cue was more salient than the taste cue. Collectively, these findings suggest the TRPM5 KO mice have some residual ability to detect SC45647 and sucrose, and, like bitter, there may be a TRPM5-independent transduction pathway for detecting these substances.

  2. Naked (C5Me5)(2)M cations (M = Sc, Ti, and V) and their fluoroarene complexes

    NARCIS (Netherlands)

    Bouwkamp, MW; Budzelaar, PHM; Gercama, J; Morales, ID; de Wolf, J; Meetsma, A; Troyanov, SI; Teuben, JH; Hessen, B; Budzelaar, Peter H.M.; Hierro Morales, Isabel Del; Troyanov, Sergei I.

    2005-01-01

    The ionic metallocene complexes [Cp*M-2][BPh4] (CP* = C5Me5) of the trivalent 3d metals Sc, Ti, and V were synthesized and structurally characterized. For M Sc, the anion interacts weakly with the metal center through one of the phenyl groups, but for M = Ti and V, the cations are naked. They each

  3. Engineering production of functional scFv antibody in E. coli by co-expressing the molecule chaperone Skp

    Directory of Open Access Journals (Sweden)

    Rongzhi eWang

    2013-11-01

    Full Text Available Single-chain variable fragment (scFv is a class of engineered antibodies generated by the fusion of the heavy (VH and light chains (VL of immunoglobulins through a short polypeptide linker. ScFv play a critical role in therapy and diagnosis of human diseases, and may in fact also be developed into a potential diagnostic and/or therapeutic agent. However, the fact that current scFv antibodies have poor stability, low solubility and affinity, seriously limits their diagnostic and clinical implication. Here we have developed four different expression vectors, and evaluated their abilities to express a soluble scFv protein. The solubility and binding activity of the purified proteins were determined using both SDS-PAGE and ELISA. Amongst the four purified proteins, the Skp co-expressed scFv showed the highest solubility, and the binding activity to antigen TLH was 3-4 fold higher than the other three purified scFv. In fact, this scFv is specific for TLH and does not cross-react with other TLH-associated proteins and could be used to detect TLH directly in real samples. These results suggest that the pACYC-Duet-skp co-expression vector might be a useful tool for the production of soluble and functional scFv antibody.

  4. A rapid and versatile method for harnessing scFv antibody fragments with various biological effector functions

    NARCIS (Netherlands)

    Helfrich, W; Haisma, HJ; Magdolen, [No Value; Luther, T; Bom, VJJ; Westra, J.; van der Hoeven, R; Kroesen, BJ; Molema, G; de Leij, L

    2000-01-01

    A versatile expression vector is described for the rapid construction and evaluation of bispecific scFvs and scFv-based fusion proteins. An important feature of this vector is the presence of two multiple cloning sites (MCS) separated by an in frame linker sequence. The first MCS was specifically

  5. Medialogi (Dansk informations brochure om Medialogi-uddannelsen, 1. til 10. semester (B.Sc. & Cand.Scient))

    DEFF Research Database (Denmark)

    Nordahl, Rolf; Andersen, Hans Jørgen

    2006-01-01

    Informationsbrochure, 28 sider, om Medialogi uddannelsen (Cand. Scient.), der udbydes af Aalborg Universitet i Aalborg, Esbjerg og København. Brochuren beskriver 1. til 10. semester af uddannelsen (B.Sc. og M.Sc.). Informationen er primært rettet mod potentielle ansøgere til Medialogi uddannelsen...

  6. Crystal, magnetic, calorimetric and electronic structure investigation of GdScGe1–x Sb x compounds

    Science.gov (United States)

    Guillou, F.; Pathak, A. K.; Hackett, T. A.; Paudyal, D.; Mudryk, Y.; Pecharsky, V. K.

    2017-12-01

    Experimental investigations of crystal structure, magnetism and heat capacity of compounds in the pseudoternary GdScGe-GdScSb system combined with density functional theory projections have been employed to clarify the interplay between the crystal structure and magnetism in this series of RTX materials (R  =  rare-earth, T   =  transition metal and X  =  p-block element). We demonstrate that the CeScSi-type structure adopted by GdScGe and CeFeSi-type structure adopted by GdScSb coexist over a limited range of compositions 0.65 ≤slant x ≤slant 0.9 . Antimony for Ge substitutions in GdScGe result in an anisotropic expansion of the unit cell of the parent that is most pronounced along the c axis. We believe that such expansion acts as the driving force for the instability of the double layer CeScSi-type structure of the parent germanide. Extensive, yet limited Sb substitutions 0 ≤slant x disappearance of the induced magnetic moments on Sc. For the parent antimonide, heat capacity measurements indicate an additional transition below the main antiferromagnetic transition.

  7. Reliability of Direct Behavior Ratings--Social Competence (DBR-SC) Data: How Many Ratings Are Necessary?

    Science.gov (United States)

    Kilgus, Stephen P.; Riley-Tillman, T. Chris; Stichter, Janine P.; Schoemann, Alexander M.; Bellesheim, Katie

    2016-01-01

    The purpose of this investigation was to evaluate the reliability of Direct Behavior Ratings--Social Competence (DBR-SC) ratings. Participants included 60 students identified as possessing deficits in social competence, as well as their 23 classroom teachers. Teachers used DBR-SC to complete ratings of 5 student behaviors within the general…

  8. Satellite cell response to erythropoietin treatment and endurance training in healthy young men

    DEFF Research Database (Denmark)

    Hoedt, Andrea; Christensen, Britt; Nellemann, Birgitte

    2016-01-01

    KEY POINT: Erythropoietin (Epo) treatment may induce myogenic differentiation factor (MyoD) expression and prevent apoptosis in satellite cells (SCs) in murine and in vitro models. Endurance training stimulates SC proliferation in vivo in murine and human skeletal muscle. In the present study, we......-term Epo treatment during disease conditions involving anaemia may impact SCs and warrants further investigation. Satellite cell (SC) proliferation is observed following erythropoitin treatment in vitro in murine myoblasts and endurance training in vivo in human skeletal muscle. The present study aimed......), sedentary-ESA (SE, n = 9), training-placebo (TP, n = 9) or training-ESA (TE, n = 8). ESA/placebo was injected once weekly and training consisted of ergometer cycling three times a week for 10 weeks. Prior to and following the intervention period, blood samples and muscle biopsies were obtained and maximal...

  9. The impact of ScOxNy interlayers on unintentional doping and threading dislocations in GaN

    International Nuclear Information System (INIS)

    Zhu, T; Moram, M A; Rao, D V Sridhara; Li, H; Kappers, M J; Oliver, R A

    2010-01-01

    To reduce the threading dislocation density in (0001) GaN grown on c-plane sapphire, a series of samples have been grown using scandium oxynitride (ScO x N y ) interlayers (ILs) on AlN-on-sapphire templates. Scanning capacitance microscopy (SCM) has been employed to investigate the unintentional doping in GaN with varying ScO x N y IL thicknesses. The use of ScO x N y ILs decreases the threading dislocation density. An unintentionally n-doped layer has been identified by SCM close to the GaN/ScO x N y interface. The average width of this conductive layer has been quantified and found to increase as the ScO x N y IL thickness increases up to 13 nm.

  10. The platinum-rich scandium silicide Sc{sub 2}Pt{sub 9}Si{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Vosswinkel, Daniel; Poettgen, Rainer [Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie

    2017-10-01

    Single crystals of Sc{sub 2}Pt{sub 9}Si{sub 3} have been obtained from an arc-melted and inductively annealed sample of the starting composition Sc:4Pt:2Si. The Sc{sub 2}Pt{sub 9}Si{sub 3} structure (Tb{sub 2}Pt{sub 9}Ge{sub 3} type, space group C2/c) was refined from single crystal X-ray diffractometer data: a=1303.4(1), b=749.9(1), c=973.5(1), β=116.44(1) {sup circle}, wR2=0.0731, 1643 F{sup 2} values and 67 variables. The structure contains three basic coordination polyhedra Sc rate at Pt{sub 11}, Si1 rate at Pt{sub 8} and Si2 rate at Pt{sub 8} which show a simple condensation pattern avoiding direct Sc-Si and Si-Si bonding.

  11. Stroke in a child with hemoglobin SC disease: a case report describing use of hydroxyurea after transfusion therapy

    Directory of Open Access Journals (Sweden)

    Diana Fridlyand

    2017-03-01

    Full Text Available Children with hemoglobin SC (HbSC disease suffer a significant incidence of silent cerebral infarcts but stroke is rare. A 2-year-old African American boy with HbSC disease presented with focal neurologic deficits associated with magnetic resonance imaging evidence of cerebral infarction with vascular abnormalities. After the acute episode he was treated with monthly transfusions and subsequently transitioned to hydroxyurea therapy. The benefits of hydroxyurea as a fetal hemoglobin inducer in HbSC disease, to ameliorate clinical symptoms are supported by retrospective studies. This case highlights the rare occurrence of stroke in a child with HbSC disease and the use of hydroxyurea therapy.

  12. Fiber Type-Specific Satellite Cell Content in Cyclists Following Heavy Training With Carbohydrate and Carbohydrate-Protein Supplementation

    Directory of Open Access Journals (Sweden)

    Alec I McKenzie

    2016-11-01

    Full Text Available The central purpose of this study was to evaluate the fiber type-specific satellite cell and myonuclear responses of endurance-trained cyclists to a block of intensified training, when supplementing with carbohydrate (CHO vs. carbohydrate-protein (PRO. In a crossover design, endurance-trained cyclists (n=8 performed two consecutive training periods, once supplementing with CHO (de facto ‘control’ condition and the other with PRO. Each training period consisted of 10 days of intensified cycle training (ICT – 120% increase in average training duration followed by 10 days of recovery (RVT – reduced volume training; 33% volume reduction vs. normal training. Skeletal muscle biopsies were obtained from the vastus lateralis before and after ICT and again following RVT. Immunofluorescent microscopy was used to quantify SCs (Pax7+, myonuclei (DAPI+, and myosin heavy chain I (MyHC I. Data are expressed as percent change ± 90% confidence limits. The 10-day block of ICTCHO increased MyHC I SC content (35 ± 28% and myonuclear density (16 ± 6%, which remained elevated following RVTCHO (SC = 69 ± 50% vs. PRE; Nuclei = 17 ± 15% vs. PRE. MyHC II SC and myonuclei were not different following ICTCHO, but were higher following RVTCHO (SC = +33 ± 31% vs. PRE; Nuclei = 15 ± 14% vs. PRE, indicating a delayed response compared to MyHC I fibers. The MyHC I SC pool increased following ICTPRO (37 ± 37%, but without a concomitant increase in myonuclei. There were no changes in MyHC II SC or myonuclei following ICTPRO. Collectively, these trained endurance cyclists possessed a relatively large pool of SCs that facilitated rapid (MyHC I and delayed (MyHC II satellite cell proliferation and myonuclear accretion with CHO. The current findings strengthen the growing body of evidence demonstrating alterations in SC number without hypertrophy. SC pool expansion is typically viewed as an advantageous response to exercise. However, when coupled with our previous

  13. Language Training - English Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional English Courses The next session will take place: from 2nd March to end of June 2009 (1/2 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144. Oral Expression The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 30 hours Price: 660 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is designed for people w...

  14. Language Training - English Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional English Courses The next session will take place: from 2nd March to end of June 2009 (1/2 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144. Oral Expression The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be an average of 8 participants per class. Speaking activities will include discussions, meeting simulations, role-plays, etc., depending on the needs of the students. Duration: 30 hours Price: 660 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is designed for people ...

  15. Síndrome hemofagocítico y salmonelosis en un paciente con hemoglobinopatía SC Hemophagocytic syndrome and salmonellosis in a patient with SC hemoglobinipathy

    Directory of Open Access Journals (Sweden)

    Luis Fernando Pinto

    1989-02-01

    Full Text Available

    Se informa el caso de un joven de 14 años con hemoglobinopatía SC que tuvo un síndrome hemofagocítico (SH secundario a salmonelosis. Se discuten las características de este síndrome y su diagnóstico diferencial. Se hace énfasis en la importancia de considerarlo entre las posibilidades diagnósticas dada la frecuencia en Colombia de las infecciones que pueden desencadenarlo, a saber: tuberculosis, salmonelosis y leishmaniasis.

    We report a case of hemophagocytlc syndrome occurrlng In a 14 year old boy with SC hemoglobinopathy and salmonellosis; the clinical features of the syndrome are discussed; the need to consider this syndrome In the differential diagnosis is emphazised, since several of the infections that may lead to It- tuberculosis, salmonellosis, lelsmaniasis. are frequently found in colombian patients

  16. Structural, electrical and magnetic properties of Sc{sup 3+} doped Mn-Zn ferrite nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Angadi, V. Jagdeesha [Department of Physics, Bangalore University, Bangalore 560056 (India); Choudhury, Leema [Department of Physics, K.G. Reddy College of Engineering & Technology, Moinabad, 501504 Ranga Reddy, Telangana (India); Sadhana, K. [Department of Physics, University College of Science, Osmania University, Saifabad, Hyderabad 500004 (India); Liu, Hsiang-Lin [Department of Physics, National Taiwan Normal University, Taipei 11677, Taiwan (China); Sandhya, R. [Department of Physics, University College of Science, Osmania University, Hyderabad 500007 (India); Matteppanavar, Shidaling; Rudraswamy, B.; Pattar, Vinayak; Anavekar, R.V. [Department of Physics, Bangalore University, Bangalore 560056 (India); Praveena, K., E-mail: praveenaou@gmail.com [Department of Physics, National Taiwan Normal University, Taipei 11677, Taiwan (China)

    2017-02-15

    Sc{sup 3+} doped Mn{sub 0.5}Zn{sub 0.5}Sc{sub y}Fe{sub 2−y}O{sub 4} (y=0.00, 0.01, 0.03 and 0.05) nanoparticles were synthesized by solution combustion method using mixture of fuels were reported for the first time. The mixture of fuels plays an important role in obtaining nano crystalline, single phase present without any heat treatment. X-ray diffraction (XRD) results confirm the formation of the single-phase ferrites which crystallize in cubic spinel structure. The Fourier transform infrared spectra (FTIR) exhibit two prominent bands around 360 cm{sup −1} and 540 cm{sup −1} which are characteristic feature of spinel ferrite. The transmission electron microscope (TEM) micrographs revealed the nanoparticles to be nearly spherical in shape and of fairly uniform size. The room temperature impedance spectra (IS) and vibrating sample magnetometry (VSM) measurements were carried out in order to study the effect of doping (Sc{sup 3+}) on the characteristic properties of Mn-Zn ferrites. Further, the frequency dependent dielectric constant and dielectric loss were found to decrease with increasing multiple Sc{sup 3+} concentration. Nyquist plot in the complex impedance spectra suggest the existence of multiple electrical responses. Magnetic measurements reveals that saturation magnetization (M{sub s}), remnant magnetization (M{sub r}), magnetic moment (η{sub B}) and magnetic particle size (D{sub m}) increase with Sc{sup 3+} ion concentration up to x=0.03 and then decrease. The values of spin canting angle (α{sub Y-K}) and the magnetic particle size (D{sub m}) are found to be in the range of 68–75° and 10–19 nm respectively with Sc{sup 3+} concentration. The room temperature Mössbauer spectra were fitted with two sextets corresponding to ions at tetrahedral (A-) and octahedral (B-) sites confirms the spinel lattice. The ferromagnetic resonance (FMR) spectra's has shown that high concentration of scandium doping leads to an increase in dipolar interaction

  17. The role of the bimodal distribution of ultra-fine silicon phase and nano-scale V-phase (AlSi2Sc2) on spark plasma sintered hypereutectic Al–Si–Sc alloys

    International Nuclear Information System (INIS)

    Raghukiran, Nadimpalli; Kumar, Ravi

    2016-01-01

    Hypereutectic Al–Si and Al–Si–Sc alloys were spark plasma sintered from corresponding gas-atomized powders. The microstructures of the Al–Si and Al–Si–Sc alloys possessed remarkably refined silicon particles in the size range of 0.38–3.5 µm and 0.35–1.16 µm respectively in contrast to the silicon particles of size greater than 100 µm typically found in conventionally cast alloys. All the sintered alloys exhibited significant ductility of as high as 85% compressive strain without failure even with the presence of relatively higher weight fraction of the brittle silicon phase. Moreover, the Al–Si–Sc alloys have shown appreciable improvement in the compressive strength over their binary counterparts due to the presence of intermetallic compound AlSi 2 Sc 2 of size 10–20 nm distributed uniformly in the matrix of those alloys. The dry sliding pin-on-disc wear tests showed improvement in the wear performance of the sintered alloys with increase in silicon content in the alloys. Further, the Al–Si–Sc ternary alloys with relatively lesser silicon content exhibited appreciable improvement in the wear resistance over their binary counterparts. The Al–Si–Sc alloys with bimodal distribution of the strengthening phases consisting of ultra-fine (sub-micron size) silicon particles and the nano-scale AlSi 2 Sc 2 improved the strength and wear properties of the alloys while retaining significant amount of ductility.

  18. Serious game training improves performance in combat life-saving interventions.

    Science.gov (United States)

    Planchon, Jerome; Vacher, Anthony; Comblet, Jeremy; Rabatel, Eric; Darses, Françoise; Mignon, Alexandre; Pasquier, Pierre

    2018-01-01

    In modern warfare, almost 25% of combat-related deaths are considered preventable if life-saving interventions are performed. Therefore, Tactical Combat Casualty Care (TCCC) training for soldiers is a major challenge. In 2014, the French Military Medical Service supported the development of 3D-SC1 ® , a serious game designed for the French TCCC program, entitled Sauvetage au Combat de niveau 1 (SC1). Our study aimed to evaluate the impact on performance of additional training with 3D-SC1 ® . The study assessed the performance of soldiers randomly assigned to one of two groups, before (measure 1) and after (measure 2) receiving additional training. This training involved either 3D-SC1 ® (Intervention group), or a DVD (Control group). The principal measure was the individual performance (on a 16-point scale), assessed by two investigators during a hands-on simulation. First, the mean performance score was compared between the two measures for Intervention and Control groups using a two-tailed paired t-test. Second, a multivariable linear regression was used to determine the difference in the impacts of 3D-SC1 ® and DVD training, and the order of presentation of the two scenarios, on the mean change from baseline in performance scores. A total of 96 subjects were evaluated: seven could not be followed-up, while 50 were randomly allocated to the Intervention group, and 39 to the Control group. Between measure 1 and measure 2, the mean (SD) performance score increased from 9.9 (3.13) to 14.1 (1.23), and from 9.4 (2.97) to 12.5 (1.83), for the Intervention group and Control group, respectively (pimproved performance, assessed by a hands-on simulation. However, our analysis did not find a statistically significant difference between the effects of these two training tools. 3D-SC1 ® could be an efficient and pedagogical tool to train soldiers in life-saving interventions. In the current context of terrorist threat, a specifically-adapted version of 3D-SC1 ® may be a

  19. Special Issue: SC13 – The International Conference for High Performance Computing, Networking, Storage and Analysis

    Directory of Open Access Journals (Sweden)

    William Gropp

    2014-01-01

    Full Text Available The technical papers program for SC13 received 449 submissions of which 90 where selected for the program giving an acceptance rate of 20%. A rigorous peer review process, including author rebuttals and a 1.5 day face-to-face program committee meeting ensured that selected papers were the very best in our field. One of the tasks at the face-to-face meeting was also to select finalists for the best paper award, from which one is selected by a committee during the conference. To further highlight their achievement of being selected as the very top tier of all the submitted papers to SC13, the authors of these finalist papers were offered the opportunity to publish extended versions of their papers in this special issue journal; all eight authors accepted.

  20. Beam Loading Tests on DC-SC Photoinjector at Peking University

    CERN Document Server

    Huang, Senlin; Chu, Xiangqiang; Ding, Yuantao; Hao, Jiankui; Jiao, Fei; Lin, Lin; Lu Xiang Yang; Quan, Shengwen; Wang, Guimei; Wang, Lifang; Xiang Rong; Xiao, Binping; Xie, Datao; Yang Li Min; Zhang, Baocheng; Zhao, Kui; Zhu, Feng

    2004-01-01

    Since the beginning of commissioning in February 2003, lots of tests on the DC-SC photoinjector test facility have been performed. At present, Q0 of the 1+1/2-cell cavity has reached ~1E8 (at 4.2K) and the average gradient was about 4MeV/m. The DC photogun can provide stable electron beams. When the power of output laser went up to 100mW (266nm), the average beam current reached 400μA. Beam loading tests have been carried out, and SC acceleration was achieved. Average current of electron beams is about 100μA after acceleration.Further investigations are in progress to improve diagnostics system and to measure the emittance, energy spread and pulse length of electron beams.

  1. In situ TEM investigation of microstructural behavior of superplastic Al–Mg–Sc alloy

    Energy Technology Data Exchange (ETDEWEB)

    Dám, Karel, E-mail: damk@vscht.cz [Department of Metals and Corrosion Engineering, Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6 (Czech Republic); Institute of Physics of the ASCR, Na Slovance 2, 182 21 Prague 8 (Czech Republic); Lejček, Pavel, E-mail: lejcekp@fzu.cz [Institute of Physics of the ASCR, Na Slovance 2, 182 21 Prague 8 (Czech Republic); Michalcová, Alena [Department of Metals and Corrosion Engineering, Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6 (Czech Republic)

    2013-02-15

    Dynamic changes in microstructure of the superplastic ultrafine-grained Al–3Mg–0.2Sc (wt.%) alloy refined by equal-channel angular pressing (ECAP). were observed by in situ transmission electron microscopy at temperatures up to 300 °C (annealing and tensile deformation) in order to simulate the initial stages of superplastic testing. It was found that the microstructure changes significantly during the preheating before the superplastic deformation, which was accompanied by decreased microhardness. During the deformation at 300 °C, high dislocation activity as well as motion of low-angle grain boundaries was observed while high-angle grain boundaries did not move due to the presence of scandium in the alloy. - Highlights: ► We performed in situ TEM annealing and straining on superplastic Al–Mg–Sc alloy. ► We simulated the conditions of early stages of superplastic testing. ► Significant changes in microstructure occur during preheating before deformation.

  2. Supported polyethylene glycol stabilized platinum nanoparticles for chemoselective hydrogenation of halonitrobenzenes in scCO2.

    Science.gov (United States)

    Cheng, Haiyang; Meng, Xiangchun; He, Limin; Lin, Weiwei; Zhao, Fengyu

    2014-02-01

    Polyethylene glycol stabilized platinum nanoparticles were immobilized on solid supports such as γ-Al2O3, SBA-15, TiO2 and active carbon, forming supported polyethylene glycol stabilized platinum nanoparticles (SPPNs). In the hydrogenation of p-chloronitrobenzene (p-CNB) in supercritical carbon dioxide (scCO2), the SPPN showed high selectivity to p-chloroaniline (>99.3%) in the whole range of conversion. Such high selectivity to corresponding haloanilines (HANs) (>99.1%) was also obtained in the hydrogenation of o-CNB, m-CNB, 2-chloro-6-nitrotoluene, p-bromonitrobenzene and m-iodonitrobenzene. The dehalogenation and the accumulation of intermediates were fully inhibited simultaneously in scCO2. The SPPN catalysts could be reused several times without loss of high selectivity in present reaction system. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. MMSE-NP-RISIC-Based Channel Equalization for MIMO-SC-FDE Troposcatter Communication Systems

    Directory of Open Access Journals (Sweden)

    Zedong Xie

    2016-01-01

    Full Text Available The impact of intersymbol interference (ISI on single-carrier frequency-domain equalization with multiple input multiple output (MIMO-SC-FDE troposcatter communication systems is severe. Most of the channel equalization methods fail to solve it completely. In this paper, given the disadvantages of the noise-predictive (NP MMSE-based and the residual intersymbol interference cancellation (RISIC equalization in the single input single output (SISO system, we focus on the combination of both equalization schemes mentioned above. After extending both of them into MIMO system for the first time, we introduce a novel MMSE-NP-RISIC equalization method for MIMO-SC-FDE troposcatter communication systems. Analysis and simulation results validate the performance of the proposed method in time-varying frequency-selective troposcatter channel at an acceptable computational complexity cost.

  4. Anomalously high thermoelectric power factor in epitaxial ScN thin films

    International Nuclear Information System (INIS)

    Kerdsongpanya, Sit; Zukauskaite, Agne; Jensen, Jens; Birch, Jens; Lu Jun; Hultman, Lars; Wingqvist, Gunilla; Eklund, Per; Van Nong, Ngo; Pryds, Nini

    2011-01-01

    Thermoelectric properties of ScN thin films grown by reactive magnetron sputtering on Al 2 O 3 (0001) wafers are reported. X-ray diffraction and elastic recoil detection analyses show that the composition of the films is close to stoichiometry with trace amounts (∼1 at. % in total) of C, O, and F. We found that the ScN thin-film exhibits a rather low electrical resistivity of ∼2.94 μΩm, while its Seebeck coefficient is approximately ∼-86 μV/K at 800 K, yielding a power factor of ∼2.5 x 10 -3 W/mK 2 . This value is anomalously high for common transition-metal nitrides.

  5. Atomic physics modeling of transmission spectra of Sc-doped aerogel foams to support OMEGA experiments

    Energy Technology Data Exchange (ETDEWEB)

    Johns, H. M., E-mail: hjohns@lanl.gov; Lanier, N. E.; Kline, J. L.; Fontes, C. J.; Perry, T. S.; Fryer, C. L.; Sherrill, M. E. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, New Mexico 87544 (United States); Brown, C. R. D.; Morton, J. W. [AWE Aldermaston, Berkshire, Reading RG7 4PR (United Kingdom); Hager, J. D. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, New Mexico 87544 (United States); Lockheed-Martin, 497 Electronics Parkway, Syracuse, New York 13221 (United States)

    2016-11-15

    We present synthetic transmission spectra generated with PrismSPECT utilizing both the ATBASE model and the Los Alamos opacity library (OPLIB) to evaluate whether an alternative choice in atomic data will impact modeling of experimental data from radiation transport experiments using Sc-doped aerogel foams (ScSi{sub 6}O{sub 12} at 75 mg/cm{sup 3} density). We have determined that in the 50-200 eV T{sub e} range there is a significant difference in the 1s-3p spectra, especially below 100 eV, and for T{sub e} = 200 eV above 5000 eV in photon energy. Examining synthetic spectra generated using OPLIB with 300 resolving power reveals spectral sensitivity to T{sub e} changes of ∼3 eV.

  6. Rapid screening platform for stabilization of scFvs in Escherichia coli.

    Science.gov (United States)

    Miller, Brian R; Glaser, Scott M; Demarest, Stephen J

    2009-01-01

    The poor biophysical properties of antibody fragments such as scFvs and diabodies can preclude their use as therapeutic agents. The non-ideal biophysical properties and insufficient thermal stability of antibody fragments often leads to poor expression, poor solubility, and a predisposition of the proteins to aggregate. We have developed a general platform for engineering stability into antibody fragments. By promoting Escherichia coli cultures to secrete scFvs directly into growth media, automated screening methods can be applied to empirically evaluate multiple stability design strategies including rational, sequence-based, and structure-based designs. Once stabilized, these antibody fragments demonstrate improved expression and durability during purification, handling, and storage. Stabilized antibody fragments can also be used as building blocks for multivalent or bispecific antibody-like molecules.

  7. Experimental nuclear level densities and γ-ray strength functions in Sc and V isotopes

    International Nuclear Information System (INIS)

    Larsen, A. C.; Guttormsen, M.; Ingebretsen, F.; Messelt, S.; Rekstad, J.; Siem, S.; Syed, N. U. H.; Chankova, R.; Loennroth, T.; Schiller, A.; Voinov, A.

    2008-01-01

    The nuclear physics group at the Oslo Cyclotron Laboratory has developed a method to extract nuclear level density and γ-ray strength function from first-generation γ-ray spectra. This method is applied on the nuclei 44,45 Sc and 50,51 V in this work. The experimental level densities of 44,45 Sc are compared to calculated level densities using a microscopic model based on BCS quasiparticles within the Nilsson level scheme. The γ-ray strength functions are also compared to theoretical expectations, showing an unexpected enhancement of the γ-ray strength for low γ energies (E γ ≤3 MeV) in all the isotopes studied here. The physical origin of this enhancement is not yet understood

  8. Optical properties and radiation response of Ce3+-doped GdScO3 crystals

    International Nuclear Information System (INIS)

    Yamaji, Akihiro; Fujimoto, Yutaka; Futami, Yoshisuke; Yokota, Yuui; Kurosawa, Shunsuke; Kochurikhin, Vladimir; Yanagida, Takayuki; Yoshikawa, Akira

    2012-01-01

    10%-Ce doped GdScO 3 perovskite type single crystal was grown by the Czochralski process. The Ce concentration in the crystal was measured. No impurity phases were observed by powder X-ray diffraction analysis. We evaluated the optical and radiation properties of the grown crystal. Ce:GdScO 3 crystal showed photo- and radio-luminescence peaks due to Ce 3+ of 5d-4f transition and colour centre. The photoluminescence decay time was sub-ns order. The relative light yield under 5.5 MeV alpha-ray excitation was calculated to be approximately 9% of BGO. (copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  9. Production of in vivo biotinylated scFv specific to almond (Prunus dulcis) proteins by recombinant Pichia pastoris.

    Science.gov (United States)

    de la Cruz, Silvia; Alcocer, Marcos; Madrid, Raquel; García, Aina; Martín, Rosario; González, Isabel; García, Teresa

    2016-06-10

    The methylotropic yeast Pichia pastoris has demonstrated its suitability for large-scale production of recombinant proteins. As an eukaryotic organism P. pastoris presents a series of advantages at expression and processing of heterologous proteins when compared with Escherichia coli. In this work, P. pastoris has been used to express a scFv from a human synthetic library previously shown to bind almond proteins. In order to facilitate purification and post processing manipulations, the scFv was engineered with a C-terminal tag and biotinylated in vivo. After purification, biotinylated scFv were bound to avidin conjugated with HRP producing a multimeric scFv. The multimeric scFv showed to maintain their ability to recognize almond protein when assayed in ELISA, reaching a LOD of 470mgkg(-1). This study describes an easy method to produce large quantities of in vivo biotinylated scFv in P. pastoris. By substituting the enzyme or fluorochromes linked to avidin, it will be possible to generate a diverse number of multimeric scFv as probes to suit different analytical platforms in the detection of almond in food products. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling.

    Science.gov (United States)

    Gong, Yi-Qing; Huang, Wei; Li, Ke-Ran; Liu, Yuan-Yuan; Cao, Guo-Fan; Cao, Cong; Jiang, Qin

    2016-09-13

    Excessive Ultra-violet (UV) radiation causes oxidative damages and apoptosis in retinal pigment epithelium (RPE) cells. Here we tested the potential activity of SC79, a novel small molecule activator of Akt, against the process. We showed that SC79 activated Akt in primary and established (ARPE-19 line) RPE cells. It protected RPE cells from UV damages possibly via inhibiting cell apoptosis. Akt inhibition, via an Akt specific inhibitor (MK-2206) or Akt1 shRNA silence, almost abolished SC79-induced RPE cytoprotection. Further studies showed that SC79 activated Akt-dependent NF-E2-related factor 2 (Nrf2) signaling and inhibited UV-induced oxidative stress in RPE cells. Reversely, Nrf2 shRNA knockdown or S40T mutation attenuated SC79-induced anti-UV activity. For the in vivo studies, we showed that intravitreal injection of SC79 significantly protected mouse retina from light damages. Based on these results, we suggest that SC79 protects RPE cells from UV damages possibly via activating Akt-Nrf2 signaling axis.

  11. SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling

    Science.gov (United States)

    Cao, Guo-fan; Cao, Cong; Jiang, Qin

    2016-01-01

    Excessive Ultra-violet (UV) radiation causes oxidative damages and apoptosis in retinal pigment epithelium (RPE) cells. Here we tested the potential activity of SC79, a novel small molecule activator of Akt, against the process. We showed that SC79 activated Akt in primary and established (ARPE-19 line) RPE cells. It protected RPE cells from UV damages possibly via inhibiting cell apoptosis. Akt inhibition, via an Akt specific inhibitor (MK-2206) or Akt1 shRNA silence, almost abolished SC79-induced RPE cytoprotection. Further studies showed that SC79 activated Akt-dependent NF-E2-related factor 2 (Nrf2) signaling and inhibited UV-induced oxidative stress in RPE cells. Reversely, Nrf2 shRNA knockdown or S40T mutation attenuated SC79-induced anti-UV activity. For the in vivo studies, we showed that intravitreal injection of SC79 significantly protected mouse retina from light damages. Based on these results, we suggest that SC79 protects RPE cells from UV damages possibly via activating Akt-Nrf2 signaling axis. PMID:27517753

  12. Isospin excitation of nucleus in 42,44,48Ca (p,n)42,44,48Sc

    International Nuclear Information System (INIS)

    Suzuki, Keiji

    2002-01-01

    To obtain information of (p,n) reaction of heavy nucleus in 100 MeV or less, 42,44,48 Ca(p,n) 42,44,48 Sc was observed on the Cyclotron Radio Isotope Center in Tohoku University. The experimental results showed that 7, 8 and 10 spin parities were determined for 42 Sc, 44 Sc and 48 SC, respectively. It was the first determination of one and two negative parity transition of 42 Sc and 48 Sc,respectively, by (p,n) reaction. The full space wave function made by 0f1p shell effective interaction by Richter,et al is good accuracy and reliability. On the (p,n) reaction at E p =35 MeV, the transition matrix elements of 42 Ca, 44 Ca and 48 Ca were derived. On the experiment of 42 Ca(p,n) 42 Sc at E p 2 on energy was agreed with the calculation results by Franey and Love. The nuclear structure of 42 Ca was thought to show more stronger U(4) symmetry, because strong GT transition at T=1 was not observed, which was expected by j-j bonding shell model calculation. (S.Y.)

  13. Substance P Differentially Modulates Firing Rate of Solitary Complex (SC) Neurons from Control and Chronic Hypoxia-Adapted Adult Rats

    Science.gov (United States)

    Nichols, Nicole L.; Powell, Frank L.; Dean, Jay B.; Putnam, Robert W.

    2014-01-01

    NK1 receptors, which bind substance P, are present in the majority of brainstem regions that contain CO2/H+-sensitive neurons that play a role in central chemosensitivity. However, the effect of substance P on the chemosensitive response of neurons from these regions has not been studied. Hypoxia increases substance P release from peripheral afferents that terminate in the caudal nucleus tractus solitarius (NTS). Here we studied the effect of substance P on the chemosensitive responses of solitary complex (SC: NTS and dorsal motor nucleus) neurons from control and chronic hypoxia-adapted (CHx) adult rats. We simultaneously measured intracellular pH and electrical responses to hypercapnic acidosis in SC neurons from control and CHx adult rats using the blind whole cell patch clamp technique and fluorescence imaging microscopy. Substance P significantly increased the basal firing rate in SC neurons from control and CHx rats, although the increase was smaller in CHx rats. However, substance P did not affect the chemosensitive response of SC neurons from either group of rats. In conclusion, we found that substance P plays a role in modulating the basal firing rate of SC neurons but the magnitude of the effect is smaller for SC neurons from CHx adult rats, implying that NK1 receptors may be down regulated in CHx adult rats. Substance P does not appear to play a role in modulating the firing rate response to hypercapnic acidosis of SC neurons from either control or CHx adult rats. PMID:24516602

  14. Substance P differentially modulates firing rate of solitary complex (SC neurons from control and chronic hypoxia-adapted adult rats.

    Directory of Open Access Journals (Sweden)

    Nicole L Nichols

    Full Text Available NK1 receptors, which bind substance P, are present in the majority of brainstem regions that contain CO2/H(+-sensitive neurons that play a role in central chemosensitivity. However, the effect of substance P on the chemosensitive response of neurons from these regions has not been studied. Hypoxia increases substance P release from peripheral afferents that terminate in the caudal nucleus tractus solitarius (NTS. Here we studied the effect of substance P on the chemosensitive responses of solitary complex (SC: NTS and dorsal motor nucleus neurons from control and chronic hypoxia-adapted (CHx adult rats. We simultaneously measured intracellular pH and electrical responses to hypercapnic acidosis in SC neurons from control and CHx adult rats using the blind whole cell patch clamp technique and fluorescence imaging microscopy. Substance P significantly increased the basal firing rate in SC neurons from control and CHx rats, although the increase was smaller in CHx rats. However, substance P did not affect the chemosensitive response of SC neurons from either group of rats. In conclusion, we found that substance P plays a role in modulating the basal firing rate of SC neurons but the magnitude of the effect is smaller for SC neurons from CHx adult rats, implying that NK1 receptors may be down regulated in CHx adult rats. Substance P does not appear to play a role in modulating the firing rate response to hypercapnic acidosis of SC neurons from either control or CHx adult rats.

  15. Influence of Mabs on PrP(Sc formation using in vitro and cell-free systems.

    Directory of Open Access Journals (Sweden)

    Binggong Chang

    Full Text Available PrP(Sc is believed to serve as a template for the conversion of PrP(C to the abnormal isoform. This process requires contact between the two proteins and implies that there may be critical contact sites that are important for conversion. We hypothesized that antibodies binding to either PrP(cor PrP(Sc would hinder or prevent the formation of the PrP(C-PrP(Sc complex and thus slow down or prevent the conversion process. Two systems were used to analyze the effect of different antibodies on PrP(Sc formation: (i neuroblastoma cells persistently infected with the 22L mouse-adapted scrapie stain, and (ii protein misfolding cyclic amplification (PMCA, which uses PrP(Sc as a template or seed, and a series of incubations and sonications, to convert PrP(C to PrP(Sc. The two systems yielded similar results, in most cases, and demonstrate that PrP-specific monoclonal antibodies (Mabs vary in their ability to inhibit the PrP(C-PrP(Sc conversion process. Based on the numerous and varied Mabs analyzed, the inhibitory effect does not appear to be epitope specific, related to PrP(C conformation, or to cell membrane localization, but is influenced by the targeted PrP region (amino vs carboxy.

  16. High performance AlScN thin film based surface acoustic wave devices with large electromechanical coupling coefficient

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wenbo; He, Xingli; Ye, Zhi, E-mail: yezhi@zju.edu.cn, E-mail: jl2@bolton.ac.uk; Wang, Xiaozhi [Department of Information Science and Electronic Engineering, Zhejiang University and Cyrus Tang Centre for Sensor Materials and Applications, 38 Zheda Road, Hangzhou 310027 (China); Mayrhofer, Patrick M.; Gillinger, Manuel; Bittner, Achim; Schmid, Ulrich [Institute of Sensor and Actuator Systems, Vienna University of Technology, Floragasse, 7/2/366-MST, A-1040 Vienna (Austria); Luo, J. K., E-mail: yezhi@zju.edu.cn, E-mail: jl2@bolton.ac.uk [Institute of Renewable Energy Environmental Technology, University of Bolton, Deane Road, Bolton BL3 5AB (United Kingdom); Department of Information Science and Electronic Engineering, Zhejiang University and Cyrus Tang Centre for Sensor Materials and Applications, 38 Zheda Road, Hangzhou 310027 (China)

    2014-09-29

    AlN and AlScN thin films with 27% scandium (Sc) were synthesized by DC magnetron sputtering deposition and used to fabricate surface acoustic wave (SAW) devices. Compared with AlN-based devices, the AlScN SAW devices exhibit much better transmission properties. Scandium doping results in electromechanical coupling coefficient, K{sup 2}, in the range of 2.0% ∼ 2.2% for a wide normalized thickness range, more than a 300% increase compared to that of AlN-based SAW devices, thus demonstrating the potential applications of AlScN in high frequency resonators, sensors, and high efficiency energy harvesting devices. The coupling coefficients of the present AlScN based SAW devices are much higher than that of the theoretical calculation based on some assumptions for AlScN piezoelectric material properties, implying there is a need for in-depth investigations on the material properties of AlScN.

  17. Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats

    Directory of Open Access Journals (Sweden)

    Lira Fábio S

    2011-08-01

    Full Text Available Abstract Aim We tested the effects of a cancer cachexia-anorexia sydrome upon the balance of anti and pro-inflammatory cytokines in the hypothalamus of sedentary or trained tumour-bearing (Walker-256 carcinosarcoma rats. Methods Animals were randomly assigned to a sedentary control (SC, sedentary tumour-bearing (ST, and sedentary pair-fed (SPF groups or, exercised control (EC, exercised tumour-bearing (ET and exercised pair-fed (EPF groups. Trained rats ran on a treadmill (60%VO2max for 60 min/d, 5 days/wk, for 8 wks. We evaluated food intake, leptin and cytokine (TNF-α, IL1β levels in the hypothalamus. Results The cumulative food intake and serum leptin concentration were reduced in ST compared to SC. Leptin gene expression in the retroperitoneal adipose tissue (RPAT was increased in SPF in comparison with SC and ST, and in the mesenteric adipose tissue (MEAT the same parameter was decreased in ST in relation to SC. Leptin levels in RPAT and MEAT were decreased in ST, when compared with SC. Exercise training was also able to reduce tumour weight when compared to ST group. In the hypothalamus, IL-1β and IL-10 gene expression was higher in ST than in SC and SPF. Cytokine concentration in hypothalamus was higher in ST (TNF-α and IL-1β, p Conclusion Cancer-induced anorexia leads towards a pro-inflammatory state in the hypothalamus, which is prevented by endurance training which induces an anti-inflammatory state, with concomitant decrease of tumour weight.

  18. In Situ Treatment Train for Remediation of Perfluoroalkyl Contaminated Groundwater: In Situ Chemical Oxidation of Sorbed Contaminants (ISCO SC)

    Science.gov (United States)

    2017-07-18

    depends on the physical characteristics of carbon such as specific surface area, pore size distribution , pore volume; chemical characteristics such as...Dickenson Southern Nevada Water Authority Distribution Statement A Page Intentionally Left Blank This report was prepared under...4800 Mark Center Drive, Suite 17D03 Alexandria, VA 22350 SERDP 11. SPONSOR/MONITOR’S REPORT NUMBER(S) ER-2423 12. DISTRIBUTION / AVAILABILITY STATEMENT

  19. Structure of 55Sc and development of the N =34 subshell closure

    Science.gov (United States)

    Steppenbeck, D.; Takeuchi, S.; Aoi, N.; Doornenbal, P.; Matsushita, M.; Wang, H.; Baba, H.; Go, S.; Holt, J. D.; Lee, J.; Matsui, K.; Michimasa, S.; Motobayashi, T.; Nishimura, D.; Otsuka, T.; Sakurai, H.; Shiga, Y.; Söderström, P.-A.; Stroberg, S. R.; Sumikama, T.; Taniuchi, R.; Tostevin, J. A.; Utsuno, Y.; Valiente-Dobón, J. J.; Yoneda, K.

    2017-12-01

    The low-lying structure of 55Sc has been investigated using in-beam γ -ray spectroscopy with the 9Be(56Ti,55Sc+γ )X one-proton removal and 9Be(55Sc,55Sc+γ )X inelastic-scattering reactions at the RIKEN Radioactive Isotope Beam Factory. Transitions with energies of 572(4), 695(5), 1539(10), 1730(20), 1854(27), 2091(19), 2452(26), and 3241(39) keV are reported, and a level scheme has been constructed using γ γ coincidence relationships and γ -ray relative intensities. The results are compared to large-scale shell-model calculations in the s d -p f model space, which account for positive-parity states from proton-hole cross-shell excitations, and to ab initio shell-model calculations from the in-medium similarity renormalization group that includes three-nucleon forces explicitly. The results of proton-removal reaction theory with the eikonal model approach were adopted to aid identification of positive-parity states in the level scheme; experimental counterparts of theoretical 1 /21+ and 3 /21+ states are suggested from measured decay patterns. The energy of the first 3 /2- state, which is sensitive to the neutron shell gap at the Fermi surface, was determined. The result indicates a rapid weakening of the N =34 subshell closure in p f -shell nuclei at Z >20 , even when only a single proton occupies the π f7 /2 orbital.

  20. THE IMPLEMENTATION OF THE TABLEAU DE BORD AT S.C. TURBOMECANICA S.A.

    OpenAIRE

    Dragos Ionut IONESCU

    2014-01-01

    This paper presents the positive aspects of the usage of the tableau de bord as a management instrument, being known for having beneficial effects on the efficiency of the managers’ working processes and on the rationalization of the managerial information system. These aspects are highlighted through the creation of the tableau de bord for the general manager of S.C. Turbomecanica S.A.

  1. Enhanced magnetization and reduced leakage current by Zr substitution in multiferroic ScMnO3

    Science.gov (United States)

    Sarkar, Tanushree; Elizabeth, Suja; Anil Kumar, P. S.

    2018-02-01

    Despite numerous attempts of electron doping in different manganites (RMnO3, R = rare earth), successful reports are scarce in the literature till date. In this paper, we have synthesized a series of phase-pure electron doped multiferroic compound Sc1-xZrxMnO3 (x = 0, 0.05, 0.1, and 0.2) and evaluated the effect of doping on structural properties, oxidation states of cations, DC magnetization, heat capacity, resistivity, dielectric behaviour and ferroelectricity in the material. The presence of Zr4+ and mixed valence state of Mn comprising of Mn2+ and Mn3+ ions are confirmed using X-ray photoelectron spectroscopy. All these samples exhibit antiferromagnetic ordering; as Zr4+ content increases, antiferromagnetic ordering gradually diminishes while shifting to low temperatures. Additionally, ferromagnetic-like interaction develops in doped systems which gives rise to hysteresis in isothermal magnetization loops with greatly enhanced magnetization in comparison to pure antiferromagnetic nature of x = 0 i.e. ScMnO3. Interestingly, even with zero magnetic moment of Sc3+, Schottky-like anomaly is observed at 5 K in heat capacity data of samples with x = 0.1 and 0.2, a result that we attribute to the highly resistive nature of doped samples. Moreover, while measuring ferroelectric hysteresis loops, we observe a significant reduction of leakage current in doped sample (x = 0.2) compared to pure ScMnO3. Additionally, the compound x = 0.2 shows improved dielectric and ferroelectric behaviour. It is proposed that doping of Zr4+ compensates for the cation deficiency and consequently eliminates the inherent oxygen vacancies by charge compensation.

  2. Antagonistic factors control the unproductive splicing of SC35 terminal intron

    OpenAIRE

    Dreumont, Natacha; Hardy, Sara; Behm-Ansmant, Isabelle; Kister, Liliane; Branlant, Christiane; St?venin, James; Bourgeois, Cyril F.

    2009-01-01

    Alternative splicing is regulated in part by variations in the relative concentrations of a variety of factors, including serine/arginine-rich (SR) proteins. The SR protein SC35 self-regulates its expression by stimulating unproductive splicing events in the 3? untranslated region of its own pre-mRNA. Using various minigene constructs containing the terminal retained intron and flanking exons, we identified in the highly conserved last exon a number of exonic splicing enhancer elements respon...

  3. La justice transitionnelle en Syrie : scénarios et options | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La justice transitionnelle en Syrie : scénarios et options. Au moment où se poursuit le conflit en Syrie, ce projet examinera les possibilités d'intenter des poursuites criminelles contre les responsables de violations des droits de la personne. En quatre années seulement, plus de 150 000 personnes sont mortes et des milliers ...

  4. Životní jubileum RNDr. Tadeáše Czudka, DrSC

    OpenAIRE

    Hrádek, M. (Mojmír)

    2012-01-01

    Dr.Tadeaš Czudek,DrSc is an eminent Czech geomorphologist who turned eighty on April 1st, 2012. In years 1956 - 1993 he worked in the Institute of Geography of the Czechoslovak Academy of Science in Brno, part of this time as head of departement of geomorphology. He was interesting in periglacial and climatic geomorphology particularly in development of planation surfaces and specially cryopediments and significance of permafrost. He published more than 240 papers and other works and ...

  5. Anomalously high thermoelectric power factor in epitaxial ScN thin films

    DEFF Research Database (Denmark)

    Kerdsongpanya, Sit; Van Nong, Ngo; Pryds, Nini

    2011-01-01

    found that the ScN thin-film exhibits a rather low electrical resistivity of ∼2.94 μΩm, while its Seebeck coefficient is approximately ∼−86 μV/K at 800 K, yielding a power factor of ∼2.5 × 10−3 W/mK2. This value is anomalously high for common transition-metal nitrides. © 2011 American Institute...

  6. A profile of the resistance training practices of elite Spanish club teams.

    Science.gov (United States)

    Reverter-Masía, Joaquín; Legaz-Arrese, Alejandro; Munguía-Izquierdo, Diego; Barbany, Joan Ramón; Serrano-Ostáriz, Enrique

    2009-08-01

    This study describes the results of a survey of the resistance training practices of the following Spanish sports teams: soccer and basketball professional leagues, and top-division leagues for handball, volleyball, indoor soccer, and field hockey. The response rate was 81.8% (77 of 94). This survey examines (a) strength and conditioning (S&C) coach profiles, (b) resistance training exercises, (c) resistance training load, (d) repetition velocity, and (e) training leading to muscle failure. The results indicate that 80.5% of coaches held a university degree, with 22% holding a master's degrees, 40% held National Federation certification, and none held Strength and Conditioning Specialist certification. Respondents relied on nonscientific sources of information to develop their conditioning programs. Fifty-eight percent of the S&C coaches were hired full time, with 18% performing the duties of a first trainer. Many S&C coaches did not use weightlifting (54%), full squat (51%), load squat jump (35%), or bench press throw (100%) exercises. Thirty-eight percent of respondents did not control the load intensity or did not use a load of 50-90% of 1 repetition maximum. For these load intensities, 70% did not perform the combination of maximum repetition velocity and nonmuscular failure. More significant deficiencies in the fundamental principles of resistance training were observed in indoor soccer, soccer, field hockey, and among lower performing handball and basketball teams. These results indicate that the profile of the S&C coaches in the Spanish teams is insufficient for an optimal application of resistance training. Spanish S&C coaches should therefore take advantage of advances made through scientific research in the area of strength and conditioning by acquiring master's degrees and specific certificates and consulting peer-reviewer journals.

  7. Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease

    Directory of Open Access Journals (Sweden)

    J. H. Gillis

    2015-01-01

    Full Text Available Acute sickle hepatic crisis (ASHC has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepatomegaly, and mild to moderate elevations in serum AST, ALT, and bilirubin. We describe the case of a patient with a history of hemoglobin SC disease and cirrhosis caused by hepatitis C presenting approximately 1 year after liver transplantation with an ASHC. The diagnosis was confirmed by liver biopsy. Our patient was treated with RBC exchange transfusions, IV hydration, and analgesia and made a complete recovery. Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease.

  8. Ab initio study of the EFG tensor at Cd impurities in Sc2O3 semiconductor

    International Nuclear Information System (INIS)

    Munoz, E.L.; Richard, D.; Errico, L.A.; Renteria, M.

    2009-01-01

    We present an ab initio study of diluted Cd impurities localized at both cation sites of the semiconductor Sc 2 O 3 . The electric-field-gradient (EFG) tensor at Cd impurities located at both cationic sites of the host structure was determined from the calculation of the electronic structure of the doped system. Calculations were performed with the full-potential augmented-plane wave plus local orbitals (APW+lo) method within the framework of the density functional theory. We studied the atomic structural relaxations and the perturbation of the electronic charge density induced by the impurities in the host system in a fully self-consistent way. We showed that the Cd impurity introduces an increase of 8% in the nearest oxygen neighbors bond-lengths, changing the EFG sign for probes located at the asymmetric cation site. The APW+lo predictions for the charged state of the Cd impurity were compared with EFG results existent in the literature, coming from time-differential γ-γ perturbed-angular-correlations experiments performed on 111 Cd-implanted Sc 2 O 3 powder samples. From the excellent agreement between theory and experiment, we can strongly suggest that the Cd acceptor impurities are ionized at room temperature. Finally, we showed that simple calculations like those performed within the point-charge model with antishielding factors do not correctly describe the problem of a Cd impurity in Sc 2 O 3 .

  9. Direct laser fabrication of three dimensional components using SC420 stainless steel

    International Nuclear Information System (INIS)

    Ravi, G.A.; Hao, X.J.; Wain, N.; Wu, X.; Attallah, M.M.

    2013-01-01

    Highlights: ► The feasibility of direct laser fabrication of SC402 alloy was studied. ► Three-dimensional (3D) components with varying thicknesses can be built using DLF to near net-shape. ► The build size and orientation affects the mechanical properties. ► Hot isostatic pressing can be used to homogenise the mechanical properties. - Abstract: Direct Laser Fabrication (DLF) has been used in the fabrication of three-dimensional (3D) near net-shape metallic parts using stainless steel SC420 powder. The mechanical properties and microstructure of the as-deposited SC420 and of hot isostatically pressed DLF builds were investigated as a function of deposition direction and sample size using tensile testing, scanning electron microscopy and X-ray diffraction. The influence of the build geometry and orientation on the microstructure and the mechanical properties was also assessed. From this work, it was evident that the DLF process can produce three dimensional parts with good mechanical properties (yield strength > 1000 MPa, tensile strength > 1400 MPa, elongation > 5%), which approach the properties of wrought products

  10. Measurement of small bowel transit time by 99Tcm-SC imaging: preliminary clinical study

    International Nuclear Information System (INIS)

    Zhang Shaohua; Xu Jingying; Bei Lian; Zhu Chaohui; Ba Jiantao

    1999-01-01

    Objective: To develop a method of measuring small bowel transit time (SBTT) by 99 Tc m -sulfur collide (SC) imaging and to compare with the method of added lactose in the test meal. Methods: 20 healthy volunteers and 26 patients with gastrointestinal disorders were studied. In fasting state, the subjects were asked to ingest the 99 Tc m -SC labelled solid meal within 5 minutes, then the image acquisition was immediately started with SPECT. The images were acquired every 15 min during the first hour, at 30 min intervals during 2∼4 hours and hourly thereafter until 80% radioactivity had entered the colon. One week later, the same procedure of imaging with 15 g lactulose added in the test meal was performed. The regions of interest (ROIs) were taken at stomach and colon, and the SBTT was calculated by deconvolution or by subtraction of the 50% time of gastric emptying from the 50% time of colon filling. Results: 1) The mean SBTT of 20 healthy volunteers was (4.2 +- 0.5) h, oral-caecum transit time (OCTT) was (4.3 +- 0.6) h; lactulose shortened the SBTT by (1.8 +- 0.6) h; 2) 26 patients showed different results of SBTT due to their different gastrointestinal disorders bases. Conclusions: 99 Tc m -SC imaging was a noninvasive and useful method to measure SBTT. The added lactulose can shorten the examination time and help to identify the time of food to the ileocecal region

  11. FPA Tuned Fuzzy Logic Controlled Synchronous Buck Converter for a Wave/SC Energy System

    Directory of Open Access Journals (Sweden)

    SAHIN, E.

    2017-02-01

    Full Text Available This paper presents a flower pollination algorithm (FPA tuned fuzzy logic controlled (FLC synchronous buck converter (SBC for an integrated wave/ supercapacitor (SC hybrid energy system. In order to compensate the irregular wave effects on electrical side of the wave energy converter (WEC, a SC unit charged by solar panels is connected in parallel to the WEC system and a SBC is controlled to provide more reliable and stable voltage to the DC load. In order to test the performance of the designed FLC, a classical proportional-integral-derivative (PID controller is also employed. Both of the controllers are optimized by FPA which is a pretty new optimization algorithm and a well-known optimization algorithm of which particle swarm optimization (PSO to minimize the integral of time weighted absolute error (ITAE performance index. Also, the other error-based objective functions are considered. The entire energy system and controllers are developed in Matlab/Simulink and realized experimentally. Real time applications are done through DS1104 Controller Board. The simulation and experimental results show that FPA tuned fuzzy logic controller provides lower value performance indices than conventional PID controller by reducing output voltage sags and swells of the wave/SC energy system.

  12. EMP Attachment 3 DOE-SC PNNL Site Dose Assessment Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, Sandra F.

    2011-12-21

    This Dose Assessment Guidance (DAG) describes methods to use to determine the Maximally-Exposed Individual (MEI) location and to estimate dose impact to that individual under the U.S. Department of Energy Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Site Environmental Monitoring Plan (EMP). This guidance applies to public dose from radioactive material releases to the air from PNNL Site operations. This document is an attachment to the Pacific Northwest National Laboratory (PNNL) Environmental Monitoring Plan (EMP) and describes dose assessment guidance for radiological air emissions. The impact of radiological air emissions from the U.S. Department of Energy Office of Science (DOE-SC) PNNL Site is indicated by dose estimates to a maximally exposed member of the public, referred to as the maximally exposed individual (MEI). Reporting requirements associated with dose to members of the public from radiological air emissions are in 40 CFR Part 61.94, WAC 246-247-080, and DOE Order 458.1. The DOE Order and state standards for dose from radioactive air emissions are consistent with U.S. Environmental Protection Agency (EPA) dose standards in 40 CFR 61.92 (i.e., 10 mrem/yr to a MEI). Despite the fact that the current Contract Requirements Document (CRD) for the DOE-SC PNNL Site operations does not include the requirement to meet DOE CRD 458.1, paragraph 2.b, public dose limits, the DOE dose limits would be met when EPA limits are met.

  13. RPL-SC dosimetric system for measuring gamma and neutron irradiation in case of emergency

    International Nuclear Information System (INIS)

    Khristova, M. G.

    1993-01-01

    A RPL-SC dosimetric system is designed based on radiophotoluminescence (RPL) and on the effect of fast neutron bombardment of silicon semiconductor (SC) diodes. The experimental prototype consists of a computerized automatic measurement system and an individual dosimetric cassette accommodating RPL and SC detectors. The equipment includes: a device for measurement of the direct voltage of Si diodes and the RPL light emitted by RPL detectors; a compartment with dosimetric cassettes to be measured; a manipulator with three positions executing automatic measurement of cassettes; a computer and a printer. The system operates in both manual and automatic modes. In the manual mode each step of the manipulator is set up by the operator who changes the ranges after they have been filled to capacity and registers the results. In the automatic mode the whole process of maintaining the supply and control voltage, of manipulator's operation, measuring, data recording and data processing are controlled by a specially designed computer programme. Main technical parameters: 1) Measurement range of absorbed dose: gamma rays - 10 -3 to 10 2 Gy; thermal neutrons - 10 -3 to 10 2 Gy; fast neutrons - 10 to 30 Gy. 2) Energy range: gamma rays - 0.04 to 1.25 MeV; thermal neutrons - 0.024 eV; fast neutrons - 0.3 to 14 MeV. 3) Relative measurement error - ±15% 4) Recurrent measurement of one and the same dose. 5) Measurement time of 1 detector - 15 sec. (author)

  14. Thermoelectric properties and thermal stability of layered chalcogenides, TlScQ2, Q = Se, Te.

    Science.gov (United States)

    Aswathy, Vijayakumar Sajitha; Sankar, Cheriyedath Raj; Varma, Manoj Raama; Assoud, Abdeljalil; Bieringer, Mario; Kleinke, Holger

    2017-12-12

    A few thallium based layered chalcogenides of α-NaFeO 2 structure-type are known for their excellent thermoelectric properties and interesting topological insulator nature. TlScQ 2 belongs to this structural category. In the present work, we have studied the electronic structure, electrical and thermal transport properties and thermal stability of the title compounds within the temperature range 2-600 K. Density functional theory (DFT) predicts a metallic nature for TlScTe 2 and a semiconducting nature for TlScSe 2 . DFT calculations also show significant lowering of energies of frontier bands upon inclusion of spin-orbit coupling contribution in the calculation. The electronic structure also shows the simultaneous occurrence of holes and electron pockets for the telluride. Experiments reveal that the telluride shows a semi-metallic behaviour whereas the selenide is a semiconductor. The thermoelectric properties for both the materials were also investigated. Both these materials possess very low thermal conductivity which is an attractive feature for thermoelectrics. However, they lack thermal stability and decompose upon warming above room temperature, as evidenced from high temperature powder X-ray diffraction and thermal analysis.

  15. Martensitic Transformation in a β-Type Mg-Sc Alloy

    Science.gov (United States)

    Ogawa, Yukiko; Ando, Daisuke; Sutou, Yuji; Somekawa, Hidetoshi; Koike, Junichi

    2017-12-01

    Recently, we found that a Mg-Sc alloy with a bcc (β) phase exhibits superelasticity and a shape memory effect at low temperature. In this work, we examined the stress-induced and thermally induced martensitic transformation of the β-type Mg-Sc alloy and investigated the crystal structure of the thermally induced martensite phase based on in situ X-ray diffraction (XRD) measurements. The lattice constants of the martensite phase were calculated to be a = 0.3285 nm, b = 0.5544 nm, and c = 0.5223 nm when we assumed that the martensite phase has an orthorhombic structure (Cmcm). Based on the lattice correspondence between a bcc and an orthorhombic structures such as that in the case of β-Ti shape memory alloys, we estimated the transformation strain of the β Mg-Sc alloy. As a result, the transformation strains along the 001, 011, and 111 directions in the β phase were calculated to be + 5.7, + 8.8, and + 3.3%, respectively.

  16. Localized Symmetry Breaking for Tuning Thermal Expansion in ScF 3 Nanoscale Frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Lei [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China; Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States; Qin, Feiyu [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China; Sanson, Andrea [Department of Physics and Astronomy, University of Padova, Padova I-35131, Italy; Huang, Liang-Feng [Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States; Pan, Zhao [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China; Li, Qiang [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China; Sun, Qiang [International Laboratory for Quantum Functional Materials of Henan, School of Physics and Engineering, Zhengzhou University, Zhengzhou 450001, China; Wang, Lu [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China; Guo, Fangmin [X-Ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States; Aydemir, Umut [Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States; Department of Chemistry, Koc University, Sariyer, Istanbul 34450, Turkey; Ren, Yang [X-Ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States; Sun, Chengjun [X-Ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States; Deng, Jinxia [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China; Aquilanti, Giuliana [Elettra Sincrotrone Trieste, Basovizza, Trieste I-34149, Italy; Rondinelli, James M. [Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States; Chen, Jun [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China; Xing, Xianran [Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China

    2018-03-15

    The local symmetry, beyond the averaged crystallographic structure, tends to bring unu-sual performances. Negative thermal expansion is a peculiar physical property of solids. Here, we report the delicate design of the localized symmetry breaking to achieve the controllable thermal expansion in ScF3 nano-scale frameworks. Intriguingly, an isotropic zero thermal expansion is concurrently engi-neered by localized symmetry breaking, with a remarkably low coefficient of thermal expansion of about +4.0×10-8/K up to 675K. This mechanism is investigated by the joint analysis of atomic pair dis-tribution function of synchrotron X-ray total scattering and extended X-ray absorption fine structure spectra. A localized rhombohedral distortion presumably plays a critical role in stiffening ScF3 nano-scale frameworks and concomitantly suppressing transverse thermal vibrations of fluorine atoms. This physical scenario is also theoretically corroborated by the extinction of phonon modes with negative Grüneisen parameters in the rhombohedral ScF3. The present work opens an untraditional chemical modification to achieve controllable thermal expansion by breaking local symmetries of materials.

  17. Pregnancy in Sickle Cell-Haemoglobin C (SC) Disease, A Retrospective Study of Birth Size and Maternal Weight Gain

    OpenAIRE

    Thame, Minerva M.; Singh-Minott, Indira; Osmond, Clive; Melbourne-Chambers, Roxanne H.; Serjeant, Graham R

    2016-01-01

    Objective: To assess pregnancy and fetal outcomes in Jamaican subjects with sickle cell-haemoglobin C (SC) disease.Study design: A retrospective chart review over 21 years (1992–2012) of all pregnancies in SC disease and a comparison group matched by gender and date of delivery in mothers with a normal haemoglobin (AA) phenotype at the University Hospital of the West Indies, Jamaica. There were 118 pregnancies in 81 patients with SC disease and 110 pregnancies in 110 in the normal comparison ...

  18. Field training

    International Nuclear Information System (INIS)

    Mumford, G.E.; Hadaway, E.H.

    1991-01-01

    Individualized, personal training can be used to increase an employee's awareness of the HSE program. Such training can stimulate personal commitment and provide personal skills that can be utilized for the benefit of the overall HSE effort. But, providing such training within our industry can be a difficult task due to the scheduling, travel arrangements, and cost associated with bringing employees from isolated, remote locations to centrally located training facilities. One method of overcoming these obstacles involves the use of field instructors to provide the training at the many, and varied number of individuals can be reached with minimal disruption to their work scheduling or to their time off. In fact, this type of on-site training is already used by some oil companies and drilling contractors with encouraging results. This paper describes one drilling contractor's experiences with such a training program. The results after eight years how that this program not only can provide and efficient, economical means of employee training, but also can have a direct application to employee motivation regarding a company's HSE effort

  19. Training Bibliography.

    Science.gov (United States)

    Vocational Training Council, Wellington (New Zealand).

    This bibliography is intended primarily for managers and trainers but will also be of interest to employers, unions, and all parties interested in improving the competency of trade and nonprofessional workers through improved training. Materials represent the topics of needs assessment, identification of training objectives, monitoring and…

  20. Genome Sequencing of Bacillus subtilis SC-8, Antagonistic to the Bacillus cereus Group, Isolated from Traditional Korean Fermented-Soybean Food

    OpenAIRE

    Yeo, In-Cheol; Lee, Nam Keun; Hahm, Young Tae

    2012-01-01

    Bacillus subtilis SC-8 is a Gram-positive bacterium displaying narrow antagonistic activity for the Bacillus cereus group. B. subtilis SC-8 was isolated from Korean traditional fermented-soybean food. Here we report the draft genome sequence of B. subtilis SC-8, including biosynthetic genes for antibiotics that may have beneficial effects for control of food-borne pathogens.

  1. Genome sequencing of Bacillus subtilis SC-8, antagonistic to the Bacillus cereus group, isolated from traditional Korean fermented-soybean food.

    Science.gov (United States)

    Yeo, In-Cheol; Lee, Nam Keun; Hahm, Young Tae

    2012-01-01

    Bacillus subtilis SC-8 is a Gram-positive bacterium displaying narrow antagonistic activity for the Bacillus cereus group. B. subtilis SC-8 was isolated from Korean traditional fermented-soybean food. Here we report the draft genome sequence of B. subtilis SC-8, including biosynthetic genes for antibiotics that may have beneficial effects for control of food-borne pathogens.

  2. Student science enrichment training program: Progress report, June 1, 1988--May 31, 1989

    Energy Technology Data Exchange (ETDEWEB)

    Sandhu, S.S.

    1989-04-21

    This is a status report on a Student Science Enrichment Training Program held at the campus of Claflin College, Orangeburg, SC. The topics of the report include the objectives of the project, participation experienced, financial incentives and support for the program, curriculum description, and estimated success of the program in stimulating an occupational interest in science and research fields by the students.

  3. Operator training

    International Nuclear Information System (INIS)

    Wirstad, J.

    1983-12-01

    The traditional operator job is changing, which among other things has generated a need for better job training. Surprisingly increased process automation has lead to increased operator qualifications, i.e. basic job training but also up-date and rehearsal training within certain fixed intervals. There are several, similar models for instructional system development available in the literature. One model which is of special interest integrates Operator Training development and Man-Machine Interfaces development. The extent to which Systematic Operator Training has been implemented varies with branches and companies. The nuclear power branch is given as an example in the report. This branch probably represents something better than the average among the process industries.(author)

  4. ENGLISH TRAINING

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch PLACES AVAILABLE Writing Professional Documents in English This course is designed for people with a good level of spoken English who need to improve their professional writing (administrative, scientific, technical). Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Date and timetable will be fixed when there are sufficient participants enrolled. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their sp...

  5. Training Standardization

    International Nuclear Information System (INIS)

    Agnihotri, Newal

    2003-01-01

    The article describes the benefits of and required process and recommendations for implementing the standardization of training in the nuclear power industry in the United States and abroad. Current Information and Communication Technologies (ICT) enable training standardization in the nuclear power industry. The delivery of training through the Internet, Intranet and video over IP will facilitate this standardization and bring multiple benefits to the nuclear power industry worldwide. As the amount of available qualified and experienced professionals decreases because of retirements and fewer nuclear engineering institutions, standardized training will help increase the number of available professionals in the industry. Technology will make it possible to use the experience of retired professionals who may be interested in working part-time from a remote location. Well-planned standardized training will prevent a fragmented approach among utilities, and it will save the industry considerable resources in the long run. It will also ensure cost-effective and safe nuclear power plant operation

  6. Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC.

    Science.gov (United States)

    Drawz, Paul; Ayyappan, Sabarish; Nouraie, Mehdi; Saraf, Santosh; Gordeuk, Victor; Hostetter, Thomas; Gladwin, Mark T; Little, Jane

    2016-02-05

    Sickle cell disease (SCD) is an inherited anemia that afflicts millions worldwide. Kidney disease is a major contributor to its morbidity and mortality. We examined contemporary and historical SCD populations to understand how renal disease behaved in hemoglobin SS (HbSS) compared with HbSC. Kidney function was examined in the multicentered Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk-PHaSST) Trial (HbSS=463; HbSC=127; years 2007-2009) and historical comparator populations from the Cooperative Study of Sickle Cell Disease (CSSCD; HbSS=708) and the Multicenter Study of Hydroxyurea in Sickle Cell Disease (MSH; HbSS=299). In adults with SCD, eGFR was lower among older individuals: -1.78 ml/min per 1.73 m(2) per year of age (95% confidence interval [95% CI], -2.06 to -1.50; Walk-PHaSST Trial), -1.75 ml/min per 1.73 m(2) per year of age (95% CI, -2.05 to -1.44; MSH), and -1.69 ml/min per 1.73 m(2) per year of age (95% CI, -2.00 to -1.38; CSSCD) in HbSS compared with -1.09 ml/min per 1.73 m(2) per year of age (95% CI, -1.39 to -0.75) in HbSC (Walk-PHaSST Trial). Macroalbuminuria was seen in 20% of participants with SCD (HbSS or HbSC; P=0.45; Walk-PHaSST Trial), but microalbuminuria was more prevalent in HbSS (44% versus 23% in HbSC; P<0.002). In the Walk-PHaSST Trial, albuminuria was associated with hemolysis (higher lactate dehydrogenase, P<0.001; higher absolute reticulocyte count, P<0.02; and lower Hb, P=0.07) and elevated systolic BP (P<0.001) in HbSS. One half of all participants with HbSS (20 of 39) versus one fifth without (41 of 228) elevated tricuspid regurgitant jet velocity (≥3 m/s; adverse prognostic indicator in SCD) had macroalbuminuria (P<0.001). In the CSSCD, overt proteinuria, detected (less sensitively) by urine dipstick, associated with higher 3-year mortality (odds ratio, 2.48; 95% CI, 1.07 to 5.77). Serum bicarbonate was lower in HbSS (23.8 versus 24.8 mEq/dl in HbSC; P<0.05) and associated with

  7. An Original Transformer and Switched-Capacitor (T & SC-Based Extension for DC-DC Boost Converter for High-Voltage/Low-Current Renewable Energy Applications: Hardware Implementation of a New T & SC Boost Converter

    Directory of Open Access Journals (Sweden)

    Sanjeevikumar Padmanaban

    2018-03-01

    Full Text Available In this article a new Transformer and Switched Capacitor-based Boost Converter (T & SC-BC is proposed for high-voltage/low-current renewable energy applications. The proposed T & SC-BC is an original extension for DC-DC boost converter which is designed by utilizing a transformer and switched capacitor (T & SC. Photovoltaic (PV energy is a fast emergent segment among the renewable energy systems. The proposed T & SC-BC combines the features of the conventional boost converter and T & SC to achieve a high voltage conversion ratio. A Maximum Power Point Tracking (MPPT controller is compulsory and necessary in a PV system to extract maximum power. Thus, a photovoltaic MPPT control mechanism also articulated for the proposed T & SC-BC. The voltage conversion ratio (Vo/Vin of proposed converter is (1 + k/(1 − D where, k is the turns ratio of the transformer and D is the duty cycle (thus, the converter provides 9.26, 13.88, 50/3 voltage conversion ratios at 78.4 duty cycle with k = 1, 2, 2.6, respectively. The conspicuous features of proposed T & SC-BC are: (i a high voltage conversion ratio (Vo/Vin; (ii continuous input current (Iin; (iii single switch topology; (iv single input source; (v low drain to source voltage (VDS rating of control switch; (vi a single inductor and a single untapped transformer are used. Moreover, the proposed T & SC-BC topology was compared with recently addressed DC-DC converters in terms of number of components, cost, voltage conversion ratio, ripples, efficiency and power range. Simulation and experimental results are provided which validate the functionality, design and concept of the proposed approach.

  8. LANGUAGE TRAINING

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch FRENCH TRAINING General and Professional French Courses The next session will take place from 26 January to 02 April 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 January to 02 April 2004. This course is designed for people wi...

  9. LANGUAGE TRAINING

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch FRENCH TRAINING General and Professional French Courses The next session will take place from 26 January to 02 April 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz : Tel. 73127. Writing Professional Documents in French The next session will take place from 26 January to 02 April 2004. This course is designed for peop...

  10. Training Attestations

    CERN Multimedia

    HR Department

    2004-01-01

    In the past, paper Training Attestations were printed during the first quarter of a New Year for Staff Members having followed courses and seminars the previous year in the context of CERN's official Training Programmes.  The attestations were sent to Divisional Training Officers (DTO's) for distribution to all Staff Members concerned within their Division. In practise many Staff Members did not find this paper useful, however some expressed a wish to be able to have access to a self-service facility in case of need. This change was discussed by the Joint Training Board (JTB) and with the DTO's during 2003 and was supported. As a consequence, following a collaboration between HR-PMD and IT-AIS, from 2004 onwards paper Training Attestations will no longer be printed and distributed as before. Those requiring a list of training followed in the past can now obtain their attestation directly from the Human Resources Toolkit (HRT) application for all training followed since 1997. https://hrt.cern...

  11. ETV TEST REPORT OF MOBILE SOURCE EMISSIONS CONTROL DEVICES: LUBRIZOL ENGINE CONTROL SYSTEMS PURIFILTER SC17L

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Lubrizol Engine Control Systems Purifilter SC17L manufactured by Lubrizol Engine Control Systems. The technology is a precious and base metal, passively regenerated particulate filter...

  12. Behavior of Equipment Support Beam Joint Directly Connected to A Steel-plate Concrete(SC) Wall

    International Nuclear Information System (INIS)

    Kim, K. S.; Kwon, K. J.

    2008-01-01

    To decrease the time for building nuclear power plants, a modular construction method, 'Steel-plate Concrete(SC)', has been investigated for over a decade. To construct a SC wall, a pair of steel plates are placed in parallel similar to a form-work in conventional reinforced concrete (RC) structures, and concrete is filled between the steel plates. Instead of removing the steel plates after the concrete has cured, the steel plates serve as components of the structural member. The exposed steel plate of SC structures serves as the base plate for the equipment support, and the headed studs welded to the steel plates are used as anchor bolts. Then, a support beam can be directly welded to the surface of the steel plate in any preferred position. In this study, we discuss the behavior and evaluation method of the equipment support joint directly connected to exposed steel plate of SC wall

  13. "Common" lead isotopic measurements in silicate glasses and minerals by laser ablation double-focusing SC-ICPMS (2017)

    Data.gov (United States)

    Department of the Interior — This dataset is related to a 2017 journal article by A. J. Pietruszka and L. A. Neymark titled "Evaluation of laser ablation double-focusing SC-ICPMS for “common”...

  14. Driverless Train

    OpenAIRE

    Törnqvist, Julia; Berglund, Emma

    2017-01-01

    As automation increases in train services, this project resulted in making a driver-less train. The main purpose was to see how security can be increased. By using sensors, today’s technologies and rebuild the stations with walls on the platforms, the safety can increase for the better. This project designs a railway system consisting of a train, boom barriers and a station. The mechanical parts were made from scratch to get the system to work beneficially. The use of Arduino as a micro contro...

  15. Bullying prevention in schools by targeting cognitions, emotions, and behavior: Evaluating the effectiveness of the REBE-ViSC program.

    Science.gov (United States)

    Trip, Simona; Bora, Carmen; Sipos-Gug, Sebastian; Tocai, Ioana; Gradinger, Petra; Yanagida, Takuya; Strohmeier, Dagmar

    2015-10-01

    The effectiveness of a class-based antibullying prevention program on cognitions, emotions, and behaviors was investigated. The program consists of a cognitive-behavioral (Rational Emotive Behavioral Education; REBE) and a behavioral (Viennese Social Competence; ViSC) component. The REBE program is based on rational emotive behavioral theory and contains 9 student lessons. The ViSC program is based on social learning theory and comprises 10 student lessons. The order of the programs was experimentally manipulated. The REBE-ViSC program was implemented in 5 schools (14 classes), the ViSC-REBE program was implemented in 3 schools (9 classes), and 3 schools (11 classes) served as an untreated control group. Data were collected during 1 school year at pretest, midpoint, and posttest. Emotions (overt and internalizing anger), cognitions (learning and entitlement), and behaviors (bullying perpetration and bullying victimization) were measured with self-assessments. To examine the effectiveness of the REBE-ViSC/ViSC-REBE program, multilevel growth models were applied (time points at Level 1, individuals at Level 2, and classes at Level 3). The analyses revealed that the program effects differed depending on the order of the programs. The REBE-ViSC condition was more effective in changing negative emotions than the ViSC-REBE condition; both experimental conditions were effective in reducing dysfunctional cognitions, whereas no behavioral change was found in the 2 experimental groups when compared with the control group. To improve program effectiveness regarding behavioral changes, a multilevel whole-school approach including a teacher component is recommended. (c) 2015 APA, all rights reserved).

  16. Synthesis, microstructural characterization and optical properties of undoped, V and Sc doped ZnO thin films

    International Nuclear Information System (INIS)

    Amezaga-Madrid, P.; Antunez-Flores, W.; Ledezma-Sillas, J.E.; Murillo-Ramirez, J.G.; Solis-Canto, O.; Vega-Becerra, O.E.; Martinez-Sanchez, R.; Miki-Yoshida, M.

    2011-01-01

    Research highlights: → Undoped, V and Sc doped ZnO thin films by Aerosol Assisted Chemical Vapour Deposition. → Optimum substrate temperatures of 673 K and 623 K for Sc and V doped films. → Around one third of the dopants in solution were deposited into the films. → Crystallite and grain size decreased with the increase of dopant concentration. → Optical band gap increased from 3.29 to 3.32 eV for undoped to 7 Sc/Zn at. %. - Abstract: Many semiconductor oxides (ZnO, TiO 2 , SnO 2 ) when doped with a low percentage of non-magnetic (V, Sc) or magnetic 3d (Co, Mn, Ni, Fe) cation behave ferromagnetically. They have attracted a great deal of interest due to the integration of semiconducting and magnetic properties in a material. ZnO is one of the most promising materials to carry out these tasks in view of the fact that it is optically transparent and has n or p type conductivity. Here, we report the synthesis, microstructural characterization and optical properties of undoped, V and Sc doped zinc oxide thin films. ZnO based thin films with additions of V and Sc were deposited by the Aerosol Assisted Chemical Vapour Deposition method. V and Sc were incorporated separately in the precursor solution. The films were uniform, transparent and non-light scattering. The microstructure of the films was characterized by Grazing Incidence X-ray Diffraction, Scanning Electron Microscopy, and Scanning Probe Microscopy. Average grain size and surface rms roughness were estimated by the measurement of Atomic Force Microscopy. The microstructure of doped ZnO thin films depended on the type and amount of dopant material incorporated. The optical properties were determined from specular reflectance and transmittance spectra. Results were analyzed to determine the optical constant and band gap of the films. An increase in the optical band gap with the content of Sc dopant was obtained.

  17. Piezoelectric characterization of Sc0.26Al0.74N layers on Si (001) substrates

    Science.gov (United States)

    Sinusía Lozano, M.; Pérez-Campos, A.; Reusch, M.; Kirste, L.; Fuchs, Th; Žukauskaitė, A.; Chen, Z.; Iriarte, G. F.

    2018-03-01

    Scandium aluminum nitride (ScAlN) films have been synthesized by pulsed-DC reactive magnetron sputtering. The degree of c-axis orientation as well as piezoelectric characteristics of the Sc0.26Al0.74N thin films grown on Si (001) at various discharge powers and processing pressures values have been investigated. According to x-ray diffraction (XRD) measurements, the texture of the as-grown Sc0.26Al0.74N thin films becomes more prominent in the [0001]-direction at the highest target power (700 W) and at the lowest processing pressure (4 mTorr). The piezoelectric response, as determined by measuring the d33 piezoelectric constant, shows a maximum value of -12 pC/N also at 4 mTorr and 700 W, confirming a direct correlation between the d33 piezoelectric constant and the degree of orientation in the [0001]-direction. The atomic concentration of Sc and Al in the synthesized ScAlN thin film, determined by secondary ion mass spectroscopy (SIMS), reveals a Sc concentration lower than in the ScAl alloy target. The piezoresponse force microscopy (PFM) shows homogeneous polarity distribution with no inversion domains. The piezoelectric layers have been used to fabricate and measure surface acoustic wave (SAW) resonators on a Sc0.26Al0.74N/Si (001) bilayer system with resonance frequency of 1.4 GHz and coupling coefficient of 0.567. Such characteristic in the frequency response reveals the potential of these materials for advanced SAW devices in applications such as next generation (5 G) wireless communication systems.

  18. Effect of the electropositive elements A = Sc, La, and Ce on the microscopic dynamics of AV2Al20.

    Science.gov (United States)

    Koza, Michael Marek; Leithe-Jasper, Andreas; Sischka, Erik; Schnelle, Walter; Borrmann, Horst; Mutka, Hannu; Grin, Yuri

    2014-12-28

    We report on the inelastic response of AV2Al20 (with A = Sc, La and Ce) probed by high-resolution inelastic neutron scattering experiments. Intense signals associated with the dynamics of Sc, La and Ce are identified in the low-energy range at 6-14 meV in ScV2Al20 and at 8-16 meV in LaV2Al20 and CeV2Al20. Their response to temperature changes between 2 and 300 K reveals a very weak softening of the modes upon heating in LaV2Al20 and CeV2Al20 and a distinguished blue shift by about 2 meV in ScV2Al20. By means of density functional theory (DFT) and lattice dynamics calculations (LDC) we show that the unusual anharmonicity of the Sc-dominated modes is due to the local potential of Sc featured by a strong quartic term. The vibrational dynamics of ScV2Al20 as well as of LaV2Al20 and CeV2Al20 is reproduced by a set of eigenmodes. To screen the validity of the DFT and LDC results they are confronted with data from X-ray diffraction measurements. The effect of the strong phonon renormalization in ScV2Al20 on thermodynamic observables is computed on grounds of the LDC derived inelastic response. To set the data in a general context of AV2Al20 compounds and their physical properties we report in addition computer and experimental results of the binary V2Al20 compound.

  19. Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats.

    Directory of Open Access Journals (Sweden)

    Daniela Farah

    Full Text Available The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group: Sedentary control (SC, Trained control (TC, Sedentary Fructose (SF and Trained Fructose (TF. Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test. Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT weight, in myocardial performance index (MPI (SF:0.42±0.04 vs. SC:0.24±0.05 and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP- SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox. The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04, arterial pressure (118±2mmHg, sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.

  20. Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

    Science.gov (United States)

    Farah, Daniela; Nunes, Jonas; Sartori, Michelle; Dias, Danielle da Silva; Sirvente, Raquel; Silva, Maikon B.; Fiorino, Patrícia; Morris, Mariana; Llesuy, Susana; Farah, Vera; Irigoyen, Maria-Cláudia; De Angelis, Kátia

    2016-01-01

    The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40–60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)- SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training. PMID:27930685

  1. Randomized Clinical Trial with e-MotionalTraining® 1.0 for Social Cognition Rehabilitation in Schizophrenia

    Directory of Open Access Journals (Sweden)

    Yolanda Maroño Souto

    2018-02-01

    Full Text Available BackgroundSchizophrenia patients present deficits in social cognition (SC, emotion and social perception, theory of mind (ToM, and attributional style. This study tested the efficacy, in real clinical conditions, of a online self-training program in SC, e-Motional Training®, in comparison with treatment as usual.MethodA randomized single-blinded multicenter clinical trial was conducted with 60 schizophrenia stable outpatients. All patients (control and intervention were treated with drug therapy, case management, and individual and group psychotherapy (not focused on SC. Intervention group was treated with e-Motional Training®, an online program devised for SC rehabilitation.Statistical analysisA descriptive analysis and parametric/non-parametric tests were used to compare both groups at baseline. Analysis of covariance was used to compared post–pre changes in SC between the two interventions. If the group effect was significant, follow-up univariate test (t-test for dependent samples was carried out in each group to verify whether the effect was due to improvement in the intervention group or deterioration in the control group. We considered statistically significant differences with P < 0.05.ResultsSignificant improvements were obtained in the intervention group in emotion recognition and most ToM variables in comparison with the control group.Discussione-Motional Training® seems to be a promising online training tool for SC deficits in schizophrenia, covering the lack of similar intervention instruments in our community.

  2. Reaction of intermetallic compounds of the ScT composition (T=Ag, Cu, Zn, Ni) with hydrogen

    International Nuclear Information System (INIS)

    Shilkin, S.P.; Volkova, L.S.; Tarasov, B.P.

    1995-01-01

    Reaction of intermetallic compounds of ScT composition (T=Ag, Cu, Zn, Ni), crystallized in CsCl structural type, with hydrogen at 0.2-10 MPa pressure and 293-673 K temperature is studied by chemical, x-ray phase and complex thermogravimetry analysis methods. It is shown that under such conditions hydrogen absorption by ScAg and ScCu is accompanied by the decay of their source matrices into scandium dihydride and metal silver and copper respectively. For ScZn a fine-dispersion mixture of scandium dihydride with zinc and hydride phase of a new zinc-containing intermetallic compound appears to be the finite reaction product. In case of ScNi a hydride phase of ScNiH 2.6 composition is produced, which is crystallized in a rhombic syngony with the lattice periods: a=0.5281±0.0007, b=0.7393±0.0009 and c=0.3327±0.0004 nm. 9 refs.; 2 tabs

  3. Structure and hydrogen storage properties of the hexagonal Laves phase Sc(Al1−xNix)2

    International Nuclear Information System (INIS)

    Sahlberg, Martin; Ångström, Jonas; Zlotea, Claudia; Beran, Premysl; Latroche, Michel; Pay Gómez, Cesar

    2012-01-01

    The crystal structures of hydrogenated and unhydrogenated Sc(Al 1−x Ni x ) 2 Laves phases have been studied by combining several diffraction techniques and it is shown that hydrogen is situated interstitially in the A 2 B 2 -sites, which have the maximum number of scandium neighbours. The hydrogen absorption/desorption behaviour has also been investigated. It is shown that a solid solution of hydrogen forms in the mother compound. The hydrogen storage capacity exceeds 1.7 H/f.u. at 374 K, and the activation energy of hydrogen desorption was determined to 4.6 kJ/mol H 2 . It is shown that these compounds share the same local coordination as Frank–Kasper-type approximants and quasicrystals, which opens up the possibility of finding many new hydride phases with these types of crystal structures. - Graphical abstract: The structure of ScNiAlDx, Sc atoms are shown in purple and Ni/Al atoms in blue and the iso-surfaces of deuterium in yellow. Revealed from refinements of neutron powder diffraction data. Highlights: ► The crystal structure of ScNiAl and ScNiAlDx is reported. ► We show the hydrogen storage properties of Sc(Al 1−x Ni x ) 2 . ► We discuss the possibility to store hydrogen in quasicrystals.

  4. Simultaneous reduction and adsorption for immobilization of uranium from aqueous solution by nano-flake Fe-SC

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Lingjun, E-mail: kongl_jun@163.com [School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510275 (China); Guangdong Provincial Key Laboratory of radioactive contamination control and resources, Guangzhou University, Guangzhou, 510275 (China); Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510275 (China); Zhu, Yuting; Wang, Min; Li, Zhixuan; Tan, Zhicong; Xu, Ruibin; Tang, Hongmei; Chang, Xiangyang [School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510275 (China); Guangdong Provincial Key Laboratory of radioactive contamination control and resources, Guangzhou University, Guangzhou, 510275 (China); Xiong, Ya [Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510275 (China); Chen, Diyun, E-mail: cdy@gzhu.edu.cn [School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510275 (China); Guangdong Provincial Key Laboratory of radioactive contamination control and resources, Guangzhou University, Guangzhou, 510275 (China)

    2016-12-15

    Uranium containing radioactive wastewater is seriously hazardous to the natural environment if it is being discharged directly. Herein, nano-flake like Fe loaded sludge carbon (Fe-SC) is synthesized by carbothermal process from Fe-rich sludge waste and applied in the immobilization of uranium in aqueous. Batch isotherm and kinetic adsorption experiments are adopted to investigate the adsorption behavior of Fe-SC to uranium in aqueous. XPS analyses were conducted to evaluate the immobilized mechanism. It was found that the carbonized temperature played significant role in the characteristics and immobilization ability of the resulted Fe-SC. The Fe-SC-800 carbonized at 800 °C takes more advantageous ability in immobilization of uranium from aqueous than the commercial available AC and powder zero valent iron. The adsorption behavior could be fitted well with the Langmuir isotherm adsorption model and pseudo-second order model. The equilibrium adsorption amount and rate for Fe-SC-800 is high to 148.99 mg g{sup -1} and 0.015 g mg{sup -1} min{sup -1}, respectively. Both reductive precipitation and physical adsorption are the main mechanisms of immobilization of uranium from aqueous by Fe-SC-800.

  5. Separation of cyclotron-produced44Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin.

    Science.gov (United States)

    Valdovinos, H F; Hernandez, R; Barnhart, T E; Graves, S; Cai, W; Nickles, R J

    2014-10-08

    Significant interest in 44 Sc as a radioactive synthon to label small molecules for positron emission tomography (PET) imaging has been recently observed. Despite the efforts of several research groups, the ideal 44 Sc production and separation method remains elusive. Herein, we propose a novel separation method to obtain 44 Sc from the proton irradiation of calcium targets based on extraction chromatography, which promises to greatly simplify current production methodologies. Using the commercially available Uranium and Tetravalent Actinides (UTEVA) extraction resin we were able to rapidly (80% of the activity generated at end of bombardment (EoB) in small ~1M HCl fractions (400μL). The chemical purity of the 44 Sc eluates was evaluated through chelation with DOTA and DTPA, and by trace metal analysis using microwave induced plasma atomic emission spectrometry. The distribution coefficients (K d ) of Sc(III) and Ca(II) in UTEVA were determined in HCl medium in a range of concentrations from zero to 12.1M. The 44 Sc obtained with our method proved to be suitable for the direct labeling of small biomolecules for PET imaging, with excellent specific activities and radiochemical purity. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Lanthanide-doped Na xScF 3+ x nanocrystals: Crystal structure evolution and multicolor tuning

    KAUST Repository

    Teng, Xue

    2012-05-23

    Rare-earth-based nanomaterials have recently drawn considerable attention because of their unique energy upconversion (UC) capabilities. However, studies of Sc 3+-based nanomaterials are still absent. Herein we report the synthesis and fine control of Na xScF 3+x nanocrystals by tuning of the ratio of oleic acid (OA, polar surfactant) to 1-octadecene (OD, nonpolar solvent). When the OA:OD ratio was increased from low (3:17) to high (3:7), the nanocrystals changed from pure monoclinic phase (Na 3ScF 6) to pure hexagonal phase (NaScF 4) via a transition stage at an intermediate OA:OD ratio (3:9) where a mixture of nanocrystals in monoclinic and hexagonal phases was obtained and the coexistence of the two phases inside individual nanocrystals was also observed. More significantly, because of the small radius of Sc 3+, Na xScF 3+x:Yb/Er nanocrystals show different UC emission from that of NaYF 4:Yb/Er nanocrystals, which broadens the applications of rare-earth-based nanomaterials ranging from optical communications to disease diagnosis. © 2012 American Chemical Society.

  7. Transcriptional stimulation via SC site of Bombyx sericin-1 gene through an interaction with a DNA binding protein SGF-3.

    Science.gov (United States)

    Matsuno, K; Takiya, S; Hui, C C; Suzuki, T; Fukuta, M; Ueno, K; Suzuki, Y

    1990-01-01

    Three protein binding sites have been identified in the upstream region of the sericin-1 gene. Two of them, SA and SC sites, have been known as putative cis-acting elements. Using synthetic oligonucleotides of these binding sites, it was found that silk gland factor-1 (SGF-1) binds to the SA site, and silk gland factor-3 (SGF-3) binds to the SC site but not to a mutated SC site, SCM. Tissue distribution of the two factors was different. SGF-3 is present abundantly in the middle silk gland (MSG) where the sericin-1 gene is transcribed specifically but is also present in other cell types, though in a much less concentration. SGF-1 is observed very abundantly in the two parts of silk gland, MSG and posterior silk gland (PSG), but not in other cells. Templates containing multimerized SA or SC sites at -39 of the sericin-1 gene promoter were tested in MSG nuclear extracts. The SC multimer strongly activated transcription, while the mutant SCM multimer did not. The SA multimer also gave a slight stimulation of transcription. These results suggest that SGF-3 stimulates transcription through an interaction with the SC site, and SGF-1 does so weakly through the SA site. Images PMID:2336359

  8. 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice.

    Science.gov (United States)

    Kulkarni, Onkar P; Sayyed, Sufyan G; Kantner, Claudia; Ryu, Mi; Schnurr, Max; Sárdy, Miklós; Leban, Johann; Jankowsky, Ruediger; Ammendola, Aldo; Doblhofer, Robert; Anders, Hans-Joachim

    2010-06-01

    Immunosuppressive treatments of systemic lupus (SLE) remain associated with significant toxicities; hence, compounds with better toxicity profiles are needed. Dihydroorotate dehydrogenase (DHODH) inhibition with leflunomide has proven to be effective in autoimmune diseases including SLE, but leflunomide can cause a variety of side effects. We hypothesized that 4SC-101, a novel DHODH inhibitor with a more favorable toxicity profile, would be as effective as high-dose cyclophosphamide (CYC) in controlling experimental SLE of female MRL(Fas)lpr mice. Daily oral gavage of 30, 100, and 300 mg/kg 4SC-101 from 12 to 22 weeks of age was compared with either vehicle or CYC treatment (30 mg/kg/week, i.p.) in terms of efficacy and toxicity. Three hundred milligrams per kilogram 4SC-101 was as effective as CYC in depleting spleen autoreactive T cells, B cells, and plasma cells as well as the respective DNA and RNA serum autoantibodies. This was associated with a comparable amelioration of the renal, dermal, and pulmonary SLE manifestations of MRL(Fas)lpr mice. However, even the highest dose of 4SC-101 had no effect on bone marrow neutrophil counts, which were significantly reduced in CYC-treated mice. Together, the novel DHODH inhibitor 4SC-101 is as effective as high dose CYC in controlling SLE without causing myelosuppression. Hence, DHODH inhibition with 4SC-101 might be suitable to treat active SLE with fewer side effects than CYC.

  9. Testing the SI × SC rule: Pollen-pistil interactions in interspecific crosses between members of the tomato clade (Solanum section Lycopersicon, Solanaceae).

    Science.gov (United States)

    Baek, You Soon; Covey, Paul A; Petersen, Jennifer J; Chetelat, Roger T; McClure, Bruce; Bedinger, Patricia A

    2015-02-01

    Interspecific reproductive barriers (IRBs) act to ensure species integrity by preventing hybridization. Previous studies on interspecific crosses in the tomato clade have focused on the success of fruit and seed set. The SI × SC rule (SI species × SC species crosses are incompatible, but the reciprocal crosses are compatible) often applies to interspecific crosses. Because SI systems in the Solanaceae affect pollen tube growth, we focused on this process in a comprehensive study of interspecific crosses in the tomato clade to test whether the SI × SC rule was always followed. Pollen tube growth was assessed in reciprocal crosses between all 13 species of the tomato clade using fluorescence microscopy. In crosses between SC and SI species, pollen tube growth follows the SI × SC rule: interspecific pollen tube rejection occurs when SI species are pollinated by SC species, but in the reciprocal crosses (SC × SI), pollen tubes reach ovaries. However, pollen tube rejection occurred in some crosses between pairs of SC species, demonstrating that a fully functional SI system is not necessary for pollen tube rejection in interspecific crosses. Further, gradations in the strength of both pistil and pollen IRBs were revealed in interspecific crosses using SC populations of generally SI species. The SI × SC rule explains many of the compatibility relations in the tomato clade, but exceptions occur with more recently evolved SC species and accessions, revealing differences in strength of both pistil and pollen IRBs. © 2015 Botanical Society of America, Inc.

  10. Scénarisation personnalisée dynamique dans les environnements virtuels pour la formation

    OpenAIRE

    Carpentier , Kévin

    2015-01-01

    This work addresses the issues of the specification of the scenario in virtual environment for training. We especially address adult lifelong training in complex domains where technical systems are difficult to apprehend and human factors are critical. Workers have to be trained to react to a wide range of situations. Virtual environment can provide this kind of training by offering them the possibility to experiment different behavior in a situation. Yet to foster learning, such environment ...

  11. Functional strength training: Seated machine vs standing cable training to improve physical function in elderly.

    Science.gov (United States)

    Balachandran, Anoop; Martins, Maria M; De Faveri, Frederico G; Alan, Ozgur; Cetinkaya, Funda; Signorile, Joseph F

    2016-09-01

    The majority of the strength training studies in older adults have incorporated fixed-form exercises using seated resistance training machines. In light of the modest improvements in physical function shown in these studies, functional or task-specific exercises, involving movement patterns that mimic daily activities, have been studied. Free-form exercises, using free-weights or cable, is another form of functional strength training. Currently, no intervention studies exist comparing free-form exercises, using cable machines, and fixed-form exercises, using seated machines in older adults. A total of 29 independently-living older adults, 65years or older, were randomized into two groups, seated machine (SM, n=10) and standing cable (SC, n=12). After 12weeks of training twice per week, groups were compared. The primary outcome was the Physical Performance Battery (PPB), a measure of physical function. Secondary outcomes were lower and upper body strength and power, activities of daily living evaluated by multiple tests including: Physical Performance Test (PPT), pan carry and gallon jug transfers, ratings of perceived exertion (RPE), and self-reported function using Patient Reported Outcomes Measurement Information System (PROMIS). Outcome assessors were blinded to participants' intervention assignments. The PPB (SC=0.23 points; SM=0.15 points) showed clinical and significant improvements, but there was no significant difference between the groups (g=0.2, 95% CI (-0.6, 1.0). For secondary outcomes, chair stand (g=0.7, 95% CI (0.2, 1.6), p=0.03) and pan carry (g=0.8, 95% CI (0.07, 1.07), p=0.04) favored SC, while chest press 1RM (g=0.2, 95% CI (0.06, 1.1), p=0.02) favored SM. There were no statistically significant group differences between PPB, gallon jug transfer, leg press 1RM, power, RPE or self-reported function. Standing cable training was not superior to seated machine training in improving physical performance in older adults. However, both training

  12. Antioxidant Activity of Essential Oil Extracted by SC-CO₂ from Seeds of Trachyspermum ammi.

    Science.gov (United States)

    Singh, Aarti; Ahmad, Anees

    2017-07-11

    Bcakground: Extracts obtained from natural sources such as plants are of immense importance for humans. Methods: Therefore this study was conducted to obtain essential oil from the seeds of T. ammi by conventional and non-conventional methods. Hydrodistillation (HD), Solvent Extraction (SE), Ultrasonication (US), and Supercritical Carbon-dioxide (SC-CO₂) extraction techniques were used to extract essential oil from the powdered seeds of T. ammi . A quality control method for each extracted oil was developed using HPTLC, FTIR, and GC-MS. The optimization process was carried out using fractional factorial design (FFD) under which three parameters were considered: pressure (150, 175, and 300 bar), temperature (25, 30, and 40 °C), and CO₂ flow rate (5, 10, 15 g/min). Results: The yield of essential oil obtained from the HD, SE, US, and SC-CO₂ methods were 1.20%, 1.82%, 2.30%, and 2.64% v/w , respectively. Antioxidant activity was determined by the DPPH and superoxide scavenging methods and the IC 50 (Inhibition Concentration) values of the T. ammi oil sample were found to be 36.41 and 20.55 µg mL -1 , respectively. Conclusion: The present paper reported that different extraction methods lead to different yields of essential oils and the choice of a suitable method is extremely important to obtain more preferred compounds. The yield was higher in the SC-CO₂ method and it is a sustainable and green extraction technique. Many important constituents were detected in analytical techniques. Antioxidant activities carried out showed that essential oil extracted from T. ammi seeds possess significant antioxidant activity.

  13. Antioxidant Activity of Essential Oil Extracted by SC-CO2 from Seeds of Trachyspermum ammi

    Directory of Open Access Journals (Sweden)

    Aarti Singh

    2017-07-01

    Full Text Available Bcakground: Extracts obtained from natural sources such as plants are of immense importance for humans. Methods: Therefore this study was conducted to obtain essential oil from the seeds of T. ammi by conventional and non-conventional methods. Hydrodistillation (HD, Solvent Extraction (SE, Ultrasonication (US, and Supercritical Carbon-dioxide (SC-CO2 extraction techniques were used to extract essential oil from the powdered seeds of T. ammi. A quality control method for each extracted oil was developed using HPTLC, FTIR, and GC-MS. The optimization process was carried out using fractional factorial design (FFD under which three parameters were considered: pressure (150, 175, and 300 bar, temperature (25, 30, and 40 °C, and CO2 flow rate (5, 10, 15 g/min. Results: The yield of essential oil obtained from the HD, SE, US, and SC-CO2 methods were 1.20%, 1.82%, 2.30%, and 2.64% v/w, respectively. Antioxidant activity was determined by the DPPH and superoxide scavenging methods and the IC50 (Inhibition Concentration values of the T. ammi oil sample were found to be 36.41 and 20.55 µg mL−1, respectively. Conclusion: The present paper reported that different extraction methods lead to different yields of essential oils and the choice of a suitable method is extremely important to obtain more preferred compounds. The yield was higher in the SC-CO2 method and it is a sustainable and green extraction technique. Many important constituents were detected in analytical techniques. Antioxidant activities carried out showed that essential oil extracted from T. ammi seeds possess significant antioxidant activity.

  14. Antioxidant Activity of Essential Oil Extracted by SC-CO2 from Seeds of Trachyspermum ammi

    Science.gov (United States)

    Singh, Aarti; Ahmad, Anees

    2017-01-01

    Bcakground: Extracts obtained from natural sources such as plants are of immense importance for humans. Methods: Therefore this study was conducted to obtain essential oil from the seeds of T. ammi by conventional and non-conventional methods. Hydrodistillation (HD), Solvent Extraction (SE), Ultrasonication (US), and Supercritical Carbon-dioxide (SC-CO2) extraction techniques were used to extract essential oil from the powdered seeds of T. ammi. A quality control method for each extracted oil was developed using HPTLC, FTIR, and GC-MS. The optimization process was carried out using fractional factorial design (FFD) under which three parameters were considered: pressure (150, 175, and 300 bar), temperature (25, 30, and 40 °C), and CO2 flow rate (5, 10, 15 g/min). Results: The yield of essential oil obtained from the HD, SE, US, and SC-CO2 methods were 1.20%, 1.82%, 2.30%, and 2.64% v/w, respectively. Antioxidant activity was determined by the DPPH and superoxide scavenging methods and the IC50 (Inhibition Concentration) values of the T. ammi oil sample were found to be 36.41 and 20.55 µg mL−1, respectively. Conclusion: The present paper reported that different extraction methods lead to different yields of essential oils and the choice of a suitable method is extremely important to obtain more preferred compounds. The yield was higher in the SC-CO2 method and it is a sustainable and green extraction technique. Many important constituents were detected in analytical techniques. Antioxidant activities carried out showed that essential oil extracted from T. ammi seeds possess significant antioxidant activity. PMID:28930268

  15. Electron spin resonance (ESR) of magnetic sublattices in Sc-substituted barium hexaferrite

    Energy Technology Data Exchange (ETDEWEB)

    Díaz-Pardo, Rebeca; Monjaras, Raúl Valenzuela [Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, México DF, 04510 Mexico (Mexico); Bierlich, Silvia; Töpfer, Jörg [Department of SciTec, University of Applied Sciences Jena, 07745 Jena (Germany)

    2016-05-15

    The partial substitution of Fe{sup 3+} by Sc{sup 3+} in barium hexaferrite has shown to be an effective method to tailor anisotropy for many novel microwave applications. Some basic studies have revealed that this substitution leads to unusual interactions among the magnetic sublattices of the ferrite. In order to investigate these interactions, samples with formula BaSc{sub x}Fe{sub 12-x}O{sub 19} (1 ≤x ≤ 2) were prepared by sintering (1300°C, 6h). After structural characterization by x-ray diffraction, their ferromagnetic resonance spectra were measured in the X-band (9.4 GHz), in the 100-500 K temperature range. For x = 2, a single, broad resonance peak was observed at the low temperatures (103 K), exhibiting a progressive splitting into two peaks for increasing T, to finally coalesce again into a single (paramagnetic) narrow peak at 473 K. These results are interpreted in terms of a substitution of Fe{sup 3+} by Sc{sup 3+} ions in the 4f{sub vi} and 2b sublattices; the diamagnetic cations disrupt the superexchange interactions and produce a splitting of the 12k sublattice (which interacts directly with the 4f{sub vi} sublattice) into two sublattices with different canting angles, and different thermal dependence. As a result, the fraction of the 12k sublattices that are nearest neighbours of substituted 4f{sub vi} sites can behave as an independent sublattice for some temperature ranges. A similar behavior is observed for all the compositions with varying degrees of amplitude, but it is more evident for x = 2. A deconvolution of peaks has been attempted, in order to shed more light into this behavior.

  16. The level of stress and coping mechanism adopted by I Year B.Sc. nursing students

    Directory of Open Access Journals (Sweden)

    C Viji Prasad

    2013-01-01

    Full Text Available Background: Stress is a fact of life that every human deals with on a daily basis. In the transitional nature of student life in professional courses like nursing, initial period of course is stressful and it adversely affects the emotional, physical, social, and academic functions. Even though the perception and response to stress and way of coping differs individually, it may produce questionable behavioral patterns in student nurses during the course of their study like feeling of loneliness, nervousness, sleeplessness, and worrying. Thus, the student nurse faces a lot of challenges and problems at the time of I Year. Objectives: The present study aimed to determine the level of stress and coping mechanisms adopted by I Year B.Sc. nursing students. Materials and Methods: A total of 60 I Year B.Sc. nursing students were selected by using non-probability convenient sampling technique. The tools used for data collection were perceived stress scale, structured coping scale, and socio- demographic proforma. Results: The studies revealed that majority of students (95.1% were in the age group of 17-19 years. The results showed that only one student (1.7% has severe stress, 46.7% has moderate stress, and remaining 51.6% has mild stress, and majority of the students (100 had average coping. There was no significant correlation (-1.167 between stress and coping mechanism of I Year B.Sc. nursing students. Conclusion: Majority of students had mild stress and average coping. The nurse administrator should plan and organize educational program for nursing students, in order to prepare them to cope up with any stressful situations. Hence, the researcher emphasizes the need for more research to improve the knowledge and by applying the research finding for future.

  17. Preparation of a Chicken scFv to Analyze Gentamicin Residue in Animal Derived Food Products.

    Science.gov (United States)

    Li, Cui; He, Jinxin; Ren, Hao; Zhang, Xiaoying; Du, Enqi; Li, Xinping

    2016-04-05

    Chicken is an ideal model for simplified recombinant antibody library generation. It has been rarely been reported to apply chicken single-chain variable fragments (scFvs) in immunoassays for the detection of antibiotic and chemical contaminants in animal food products. In this study, the scFvs (S-1 and S-5) were isolated from a phage display library derived from a hyperimmunized chicken. The checker board titration revealed that the optimum concentrations of S-1 and S-5 were 0.78 μg/mL and 0.44 μg/mL respectively, to obtain OD450 around 1.0 at 5 μg/mL of Gent-OVA coating concentration. Both S-1 and S-5 exhibited negligible cross reactivity with kanamycin and amikacin. The 50% inhibitory concentration (IC50) of S-1 and S-5 were 12.418 ng/mL and 14.674 ng/mL respectively. In the indirect competitive ELISA (ic-ELISA), the limits of detection for S-1 and S-5 were 0.147 ng/mL and 0.219 ng/mL respectively. The mean recovery for Gent ranged from 60.91% to 118.09% with no more than 10.35% relative standard deviation (RSD) between the intra-assay and the inter-assay. These results indicate the chicken scFv based ic-ELISA method is suitable for the detection of Gent residue in animal derived edible tissues and milk.

  18. Comparison of renal allograft (AG) biopsy diagnosis and temporal quantitation of Tc-99m sulfur colloid (SC) in clinically suspected AG rejection

    International Nuclear Information System (INIS)

    George, E.A.; Brown, W.N.; Carney, K.; Naidu, R.G.; Palmer, D.C.

    1984-01-01

    The purpose of this study was to evaluate the diagnostic efficacy of temporal quantitation of SC compared to tissue diagnosis of AG needle biopsy (Bx). The principal clinical criteria for patient selection were sequential or persistent reduction (at least 40-50%) of AG function as determined by serial serum creatinine levels. Thirty-four AG recipients were examined with SC and subsequent AG Bx in 37 instances. %SC AG accumulation and bone marrow extraction were interpreted in view of the significant sequential of persistent reduction of Ag function. Each AG Bx was collected from multiple needle aspirates and processed for light microscopy and immunoflorescent staining. Bx and SC exam were evaluated for acute rejection (AR), chronic rejection (CR) or other, non-rejection pathology. Acute tissue changes superimposed on chronic were regarded as AR. Acute tissue changes and % SC AG accumulation in the rejection range were graded as mild, moderate and marked. In AR there was 28/28 agreement of Bx and SC diagnosis; of which 7/28 were superimposed on CR. In Cr Bx and SC agreed in 3/7 instances, in 3/7 SC Dx was AR and in 1/7 SC exam was normal. Sensitivity and specificity of the SC diagnosis in this series was 100% and 63% for AR, 43% and 100% for CR and 97% and 100% in all instances of rejection. Bx and SC grading of AR agreed in 64%. In conclusion, temporal quantitation of SC demonstrated overall good correlation with AG Bx diagnosis in this series. The poor sensitivity of 43% of SC in Cr and only 64% correlation in grading AR may be due to inherent Bx sampling and SC data analysis error

  19. The fast piezo-based frequency tuner for sc CH-cavities

    Energy Technology Data Exchange (ETDEWEB)

    Amberg, Michael [Helmholtz-Institut Mainz (HIM), Mainz (Germany); IAP University of Frankfurt, Frankfurt am Main (Germany); Aulenbacher, Kurt; Barth, Winfried [Helmholtz-Institut Mainz (HIM), Mainz (Germany); Busch, Marco; Dziuba, Florian; Podlech, Holger; Ratzinger, Ulrich [IAP University of Frankfurt, Frankfurt am Main (Germany)

    2014-07-01

    Superconducting (sc) structures have to fulfill strict mechanical requirements to assure a stable operation of a cavity. Even small mechanical disturbances caused by effects like microphonic noise, pressure fluctuations of the liquid helium bath or Lorentz force detuning can change the resonance frequency of the cavity in the range of several hundred kHz. To control the slow and fast frequency variations during operation a compact frequency tuner prototype equipped with a stepper motor and a piezo actuator has been developed at the Institute for Applied Physics (IAP) of Frankfurt University. The tuner design and the results of first mechanical tests at room temperature of the first prototype are presented.

  20. Ab initio structures and stabilities of HeTM3+ (TM=Sc-Cu)

    International Nuclear Information System (INIS)

    Wilson, David J.D.; Marsden, Colin J.; Nagy-Felsobuki, Ellak I. von

    2002-01-01

    The electronic structure and molecular properties of triply charged transition metal helides, HeTM 3+ (where TM = Sc-Cu), have been investigated employing CCSD(T), MCSCF and MRCI methods. Dissociation energies and harmonic vibrational frequencies have also been determined. For all the triply charged helides, the ground state is dominated by the 3d n electronic configuration. In addition, states with configurations that have holes in the metal 3d σ orbital exhibit greater binding energies. The suitability of single-reference methods and diagnostics for this series has been investigated, with the MCSCF wave function being the most reliable diagnostic tool for the applicability of SCF methods

  1. O uso do endomarketing pelas empresas de São Miguel do Oeste-SC

    OpenAIRE

    Josiane Romancini; Sandra Regina Walginski

    2012-01-01

    Endomarketing ou marketing interno são ações de Marketing voltadas para o público interno das empresas. O artigo que se apresenta a seguir foi baseado em uma pesquisa de campo financiada pelo Projeto PIC SENAC realizada na cidade de São Miguel do Oeste/SC, no ano de 2010, onde, em um primeiro momento, pesquisou-se os gestores das empresas que eram associados à Câmara de Dirigentes Lojistas naquele ano. Com os rumos daquela pesquisa, buscou-se, no ano de 2011, trabalhar uma segunda etapa, dest...

  2. Proton and oxide ion conductivity of doped LaScO3

    DEFF Research Database (Denmark)

    Lybye, D.; Bonanos, N.

    1999-01-01

    . At temperatures below 800 degrees C and low partial pressure of oxygen, proton conduction was dominant. Above this temperature, the ionic conductivity is dominated by oxide ion transport. The protonic transport number was estimated from the conductivities measured in dry and in water-moisturised gas. An isotope......The conductivity of La0.9Sr0.1Sc0.9Mg0.1O3 has been studied by impedance spectroscopy in controlled atmospheres. The material was found to be a mixed conductor with p-type conduction at high oxygen partial pressures and a combined proton and oxide ion conductor at low oxygen partial pressures...

  3. Production Potential of 47Sc Using Spallation Neutron Flux at the Los Alamos Isotope Production Facility

    Science.gov (United States)

    2014-03-27

    up, and high-fidelity delayed-gamma emission. MCNP6 is a fusion of MCNPX and MCNP5. MCNP5 allows for neutral particle and electron transport, while...bins will be listed [20]. This tally, in combination with the eighth entry on MCNPs LCA physics model card entry, NOACT, is very useful in extracting...19 and 23 (K, Ca, Sc, Ti, and V) resulting from direct neutron reactions. The 8th LCA entry of NOACT=-2 forces the model to assume all particles react

  4. Effect of Extensive Rolling on Mechanical Properties of An Al-Mg-Sc Alloy

    Science.gov (United States)

    Dubyna, Andrii; Mogucheva, Anna; Kaibyshev, Rustam

    Sheets of an Al-6%Mg-0.5%Mn-0.2%Sc-0.07%Zr alloy with ultrafine-grained structure containing a high dislocation density (ρ 1015 m-2) were produced by equal channel angular pressing (ECAP) to a strain of ɛ 12 at a temperature of 300°C followed by cold rolling to a reduction of 90%. This material exhibited a yield stress of 600 MPa, an ultimate strength of 640 MPa, while elongation-to-failure decreased to 2%. It was shown that dislocation strengthening attributed to extensive cold rolling (CR) plays a major role in achieving high strength in this alloy.

  5. Pressure protection against vacuum failures on the cryostats for LEP sc cavities

    International Nuclear Information System (INIS)

    Cavallari, G.; Guesewell, D.; Stierlin, R.; Gorine, I.

    1990-01-01

    Three types of moderate vacuum failure were studied experimentally on a prototype of the sc cavity cryostats developed for LEP. The observations were interpreted using a simplified description of the liquid helium (LHe) bath and extrapolated to the worst possible pressure rise. This was verified in a last test by breaking the cavity vacuum in a fraction of a second with an 80 mm diameter valve. It was concluded that this simulated indeed the worst case and that, as a minimum, a rupture disk of 20 cm 2 is required on a low-impedance safety pipe to exclude excessive peak pressures and damage to the cavity. (author)

  6. A humanized anti-M2 scFv shows protective in vitro activity against influenza

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew M [Los Alamos National Laboratory; Velappan, Nileena [Los Alamos National Laboratory; Schmidt, Jurgen G [Los Alamos National Laboratory

    2008-01-01

    M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar activity to the parental mAb: it is able to recognize M2 in its native context on cell surfaces and is able to show protective in vitro activity against influenza, and so represents a potential lead antibody candidate for universal prophylactic or therapeutic intervention in influenza.

  7. FORMIGAS (Hymenoptera: Formicidae) EM CENTROS DE SAÚDE DA FAMÍLIA DE CHAPECÓ, SC

    OpenAIRE

    Schwingel, Isabella; Lutinski, Junir Antonio; de Quadros, Suiane Oliveira; Busato, Maria Assunta; Teo, Carla Rosane Paz Arruda

    2016-01-01

    As formigas se caracterizam pela ampla distribuição e abundância nos ambientes terrestres. Algumas espécies são consideradas pragas em ambientes urbanos, devido à sua capacidade de se adaptar a esse meio. Considerando a importância das formigas para a saúde pública, este trabalho teve como objetivos caracterizar a assembleia de formigas que ocorre nos Centros de Saúde da Família (CSF) de Chapecó, SC, e identificar os ambientes mais propensos à sua infestação. O estudo foi desenvolvido em 10 C...

  8. Mechanical Testing of 3D Fabric Composites and Their Matrix Material SC-15

    Science.gov (United States)

    2012-11-01

    panels using a waterjet cutting system. A second panel of pure SC-15 matrix was then made to analyze the response of the material in both tension...cured into a 3 20-in × 20-in × 1/8-in panel. Tension and compressive samples were cut from the panel using water jet. Figure 1. The cure...Samples were cut to 5.5 in × 0.5 in. The thickness of the S2 glass varied considerably on the bag side; therefore, the bag surface was ground down to

  9. Stress and strain effects on the electronic structure and optical properties of ScN monolayer

    Science.gov (United States)

    Tamleh, Shirin; Rezaei, Ghasem; Jalilian, Jaafar

    2018-02-01

    Based on the density functional theory, electronic and optical properties of a monolayer scandium nitride structure have been studied under different strain conditions. Our results indicate that both biaxial compressive and tensile strain effects lead to change the band gap of this structure with different rates. Also, optical absorption spectrum peaks experience an obvious red and blue shifts with the exerting of tensile and compressive strains, respectively. Our results express that ScN monolayer can be the promising candidate for the future nano-base electrical and optical devices.

  10. Enrichment of Sc{sub 2}O{sub 3} and TiO{sub 2} from bauxite ore residues

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Bona; Li, Guanghui, E-mail: liguangh@csu.edu.cn; Luo, Jun; Ye, Qing; Liu, Mingxia; Peng, Zhiwei; Jiang, Tao

    2017-06-05

    Highlights: • Sc{sub 2}O{sub 3} and TiO{sub 2} from bauxite ore residue were successfully enriched. • H{sub 3}PO{sub 4} and NaOH were efficient for enriching Sc{sub 2}O{sub 3} and TiO{sub 2} by removing SiO{sub 2}, Al{sub 2}O{sub 3}, and partial Fe{sub 2}O{sub 3} and CaO. • Enriching mechanism of Sc{sub 2}O{sub 3} and TiO{sub 2} was explicitly explained. - Abstract: As a major byproduct generated in the alumina industry, bauxite ore residue is an important reserve of scandium and titanium. In this study, the feasibility and mechanism of enriching Sc{sub 2}O{sub 3} and TiO{sub 2} from a non-magnetic material, which was obtained from carbothermal reductive roasting and magnetic separation of bauxite ore residue, were investigated based on a two-step (acidic and alkali) leaching process. It was revealed that approximately 78% SiO{sub 2} and 30–40% of CaO, FeO and Al{sub 2}O{sub 3} were removed from a non-magnetic material with 0.0134 wt.% Sc{sub 2}O{sub 3} and 7.64 wt.% TiO{sub 2} by phosphoric acidic leaching, while about 95% Al{sub 2}O{sub 3} and P{sub 2}O{sub 5} were further leached by subsequent sodium hydroxide leaching of the upper-stream leach residue. A Sc{sub 2}O{sub 3}-, TiO{sub 2}- rich material containing 0.044 wt.% Sc{sub 2}O{sub 3} and 25.5 wt.% TiO{sub 2} was obtained, the recovery and the enrichment factor of Sc{sub 2}O{sub 3} and TiO{sub 2} were about 85% and 5, respectively. The enrichment of Sc{sub 2}O{sub 3} was attributed to higher pH (>3.3) of phosphoric acid solution than its dissolution pH{sup 0}, and the enrichment of TiO{sub 2} was mainly associated with the insoluble perovskite (CaTiO{sub 3}) in the acidic solution at ambient temperature. As Sc{sub 2}O{sub 3} and TiO{sub 2} cannot be dissolved in the alkali solution, they were further enriched in the leach residue.

  11. Evaluation of the first 44Sc-labeled Affibody molecule for imaging of HER2-expressing tumors

    International Nuclear Information System (INIS)

    Honarvar, Hadis; Müller, Cristina; Cohrs, Susan; Haller, Stephanie; Westerlund, Kristina; Karlström, Amelie Eriksson; Meulen, Nicholas P. van der; Schibli, Roger; Tolmachev, Vladimir

    2017-01-01

    Introduction: Affibody molecules are small (58 amino acids) high-affinity proteins based on a tri-helix non-immunoglobulin scaffold. A clinical study has demonstrated that PET imaging using Affibody molecules labeled with 68 Ga (T ½ = 68 min) can visualize metastases of breast cancer expressing human epidermal growth factor receptor type 2 (HER2) and provide discrimination between tumors with high and low expression level. This may help to identify breast cancer patients benefiting from HER2-targeting therapies. The best discrimination was at 4 h post injection. Due to longer half-life, a positron-emitting radionuclide 44 Sc (T ½ = 4.04 h) might be a preferable label for Affibody molecules for imaging at several hours after injection. Methods: A synthetic second-generation anti-HER2 Affibody molecule Z HER2:2891 was labeled with 44 Sc via a DOTA-chelator conjugated to the N-terminal amino group. Binding specificity, affinity and cellular processing 44 Sc-DOTA-Z HER2:2891 and 68 Ga-DOTA-Z HER2:2891 were compared in vitro using HER2-expressing cells. Biodistribution and imaging properties of 44 Sc-DOTA-Z HER2:2891 and 68 Ga-DOTA-Z HER2:2891 were evaluated in Balb/c nude mice bearing HER2-expression xenografts. Results: The labeling yield of 98 ± 2% and specific activity of 7.8 GBq/μmol were obtained. The conjugate demonstrated specific binding to HER2-expressing SKOV3.ip cells in vitro and to SKOV3.ip xenografts in nude mice. The distribution of radioactivity at 3 h post injection was similar for 44 Sc-DOTA-Z HER2:2891 and 68 Ga-DOTA-Z HER2:2891 , but the blood clearance of the 44 Sc-labeled variant was slower and the tumor-to-blood ratio was reduced (15 ± 2 for 44 Sc-DOTA-Z HER2:2891 vs 46 ± 9 for 68 Ga-DOTA-Z HER2:2891 ). At 6 h after injection of 44 Sc-DOTA-Z HER2:2891 the tumor uptake was 8 ± 2% IA/g and the tumor-to-blood ratio was 51 ± 8. Imaging using small-animal PET/CT demonstrated that 44 Sc-DOTA-Z HER2:2891 provides specific and high

  12. Strength Training Effects on Muscular Regeneration after ACL Reconstruction.

    Science.gov (United States)

    Friedmann-Bette, Birgit; Profit, Francesca; Gwechenberger, Thomas; Weiberg, Nadine; Parstorfer, Mario; Weber, Marc-Andre; Streich, Nikolaus; Barié, Alexander

    2018-01-31

    Protracted quadriceps muscle atrophy is observed after anterior cruciate ligament reconstruction (ACL-R). The aim of this study was to assess if quadriceps strength training with eccentric overload (CON/ECC) is more efficient to induce muscle regeneration after ACL-R than conventional concentric/eccentric (CON/ECC) strength training. Biopsies from the vastus lateralis muscle were obtained from 37 recreational athletes after 12 weeks of regular rehabilitation following ACL-R and again after 12 weeks with twice a week either conventional CON/ECC (n = 16) or CON/ECC (n = 21) one-legged supervised leg-press training. Immunohistochemical analyses were used to determine satellite cell number (SC, Pax7), activated SCs (Pax7/MyoD), fibers expressing myosin heavy chain (MHC) I, II and neonatal, fiber cross sectional area (FCSA). Magnetic resonance imaging was performed to measure quadriceps cross sectional area (MCSA) and isokinetic testing for the measurement of quadriceps strength. CON/ECC induced a significantly (p = 0.002) greater increase in MCSA than CON/ECC. There also was a significant increase in the FCSAs of all fiber types and in quadriceps strength, however, without significant difference between training groups. Only CON/ECC training lead to a significant (p hypertrophy than CON/ECC, however, at the same time inducing a less favorable slower muscle phenotype for strong and fast movements and without the hypothesized enhancing effect on SC activation.

  13. Issues associated with the metalorganic chemical vapor deposition of ScGaN and YGaN alloys.

    Energy Technology Data Exchange (ETDEWEB)

    Koleske, Daniel David; Knapp, James Arthur; Lee, Stephen Roger; Crawford, Mary Hagerott; Creighton, James Randall; Cross, Karen Charlene; Thaler, Gerald

    2009-07-01

    The most energy efficient solid state white light source will likely be a combination of individually efficient red, green, and blue LED. For any multi-color approach to be successful the efficiency of deep green LEDs must be significantly improved. While traditional approaches to improve InGaN materials have yielded incremental success, we proposed a novel approach using group IIIA and IIIB nitride semiconductors to produce efficient green and high wavelength LEDs. To obtain longer wavelength LEDs in the nitrides, we attempted to combine scandium (Sc) and yttrium (Y) with gallium (Ga) to produce ScGaN and YGaN for the quantum well (QW) active regions. Based on linear extrapolation of the proposed bandgaps of ScN (2.15 eV), YN (0.8 eV) and GaN (3.4 eV), we expected that LEDs could be fabricated from the UV (410 nm) to the IR (1600 nm), and therefore cover all visible wavelengths. The growth of these novel alloys potentially provided several advantages over the more traditional InGaN QW regions including: higher growth temperatures more compatible with GaN growth, closer lattice matching to GaN, and reduced phase separation than is commonly observed in InGaN growth. One drawback to using ScGaN and YGaN films as the active regions in LEDs is that little research has been conducted on their growth, specifically, are there metalorganic precursors that are suitable for growth, are the bandgaps direct or indirect, can the materials be grown directly on GaN with a minimal defect formation, as well as other issues related to growth. The major impediment to the growth of ScGaN and YGaN alloys was the low volatility of metalorganic precursors. Despite this impediment some progress was made in incorporation of Sc and Y into GaN which is detailed in this report. Primarily, we were able to incorporate up to 5 x 10{sup 18} cm{sup -3} Y atoms into a GaN film, which are far below the alloy concentrations needed to evaluate the YGaN optical properties. After a no-cost extension was

  14. 44Sc-DOTA-BN[2-14]NH2 in comparison to 68Ga-DOTA-BN[2-14]NH2 in pre-clinical investigation. Is 44Sc a potential radionuclide for PET?

    International Nuclear Information System (INIS)

    Koumarianou, E.; Loktionova, N.S.; Fellner, M.; Roesch, F.; Thews, O.; Pawlak, D.; Archimandritis, S.C.; Mikolajczak, R.

    2012-01-01

    Aim: In the present study we demonstrate the in vitro and in vivo comparison of the 44 Sc and 68 Ga labeled DOTA-BN[2-14]NH 2 . 44 Sc is a positron emitter with a half life of 3.92 h. Hence it could be used for PET imaging with ligands requiring longer observation time than in the case of 68 Ga. Methods: The binding affinity of nat Sc-DOTA-BN[2-14]NH 2 and nat Ga-DOTA-BN[2-14]NH 2 to GRP receptors was studied in competition to [ 125 I-Tyr 4 ]-Bombesin in the human prostate cancer cell line PC-3. A preliminary biodistribution in normal rats was performed, while first microPET images were assessed in male Copenhagen rats bearing the androgen-independent Dunning R-3327-AT-1 prostate cancer tumor. Results: The affinity to GRP receptors in the PC-3 cell line was higher for nat Ga-DOTA-BN[2-14]NH 2 (IC 50 (nM)=0.85±0.06) than that of nat Sc-DOTA-BN[2-14]NH 2 (IC 50 (nM)=6.49±0.13). The internalization rate of 68 Ga labeled DOTA-BN[2-14]NH 2 was slower than that of 44 Sc, but their final internalization percents were comparable. 68 Ga-DOTA-BN[2-14]NH 2 was externalized faster than 44 Sc-DOTA-BN[2-14]NH 2 . The biodistribution of 44 Sc-DOTA-BN[2-14]NH 2 and 68 Ga-DOTA-BN[2-14]NH 2 in normal rats revealed a higher uptake in target organs and tissues of the first one while both excreted mainly through urinary tract. In microPET images both tracers were accumulated in the tumor with similar uptake patterns. Conclusions: Despite the differences in the receptor affinity both the 68 Ga- and the 44 Sc-labeled DOTA-BN[2-14]NH 2 tracers showed comparable distribution and similar time constants of uptake and elimination. Moreover no differences in tumor accumulation (neither in the overall uptake nor in the dynamics) were observed from the microPet imaging. From that perspective the use of either 44 Sc or 68 Ga for detecting tumors with GRP receptors is equivalent. - Highlights: ► In vitro and in vivo evaluation of 44 Sc- and 68 Ga-DOTA-BN[2-14]NH 2 in reference to published

  15. Examination of the effect of Sc on 2000 and 7000 series aluminium alloy castings: for improvements in fusion welding

    International Nuclear Information System (INIS)

    Norman, A.F.; Hyde, K.; Costello, F.; Thompson, S.; Birley, S.; Prangnell, P.B.

    2003-01-01

    It has been reported that small additions of scandium (Sc) can improve the weldability and mechanical properties of some aluminium aerospace alloys that are normally considered to be 'unweldable'. In order to determine the mechanisms by which these improvements occur, and more rapidly arrive at optimum Sc addition levels, small wedge-shaped castings have been used to simulate the cooling rates found in MIG/TIG welds. Using this technique, a range of Sc addition levels have been made to two typical Al-aerospace alloys, 2024 and 7475. It has been found that when the Sc level exceeds a critical concentration, small Al 3 Sc primary particles form in the melt and act as very efficient grain nucleants, resulting in simulated fusion zone grain sizes as fine as 15 μm. This exceptional level of grain refinement produced an unusual grain structure that exhibited no dendritic, or cellular, substructure and a large increase in strength and ductility of the castings. Sc also produced changes in the alloy's freezing paths, which cannot yet be fully explained, but led to the appearance of the W phase in the 2024 alloy and, in both alloys, an overall reduction in the amount of eutectic formed during solidification. When coupled with the high level of grain refinement, this behaviour could be used to explain the increased strength and ductility of the castings. In 2000 and 7000 series aluminium alloys, it is therefore, anticipated that optimised Sc bearing filler wires will significantly improve the mechanical properties of the weld metal, as well as reducing the tendency for solidification cracking

  16. Effect of oral IQoro R and palatal plate training in post-stroke, four-quadrant facial dysfunction and dysphagia: A comparison study.

    Science.gov (United States)

    Hägg, Mary; Tibbling, Lita

    2015-09-01

    Training with either a palatal plate (PP) or an oral IQoro(R) screen (IQS) in patients with longstanding facial dysfunction and dysphagia after stroke can significantly improve facial activity (FA) in all four facial quadrants as well as swallowing capacity (SC). Improvements remained at late follow-up. The training modalities did not significantly differ in ameliorating facial dysfunction and dysphagia in these patients. However, IQS training has practical and economic advantages over PP training. This study compared PP and oral IQS training in terms of (i) effect on four-quadrant facial dysfunction and dysphagia after a first-ever stroke, and (ii) whether the training effect persisted at late follow-up. Patients were included during two periods; 13 patients in 2005-2008 trained with a PP, while 18 patients in 2009-2012 trained with an IQS. Four-quadrant facial dysfunction was assessed with an FA test and swallowing dysfunction with a SC test: before and after a 3-month training period and at late follow-up. FA and SC significantly improved (p stroke incidence and the start of training was long or short.

  17. SC2IT: a cloud computing interface that makes computational science available to non-specialists

    Science.gov (United States)

    Jorissen, Kevin; Vila, Fernando; Rehr, John

    2012-10-01

    Computational work is a vital part of much scientific research. In materials science research in particular, theoretical models are usually needed to understand measurements. There is currently a double barrier that keeps a broad class of researchers from using state-of-the-art materials science (MS) codes: the software typically lacks user-friendliness, and the hardware requirements can demand a significant investment, e.g. the purchase of a Beowulf cluster. Scientific Cloud Computing (SCC) has the potential to breach this barrier and make computational science accessible to a wide class of non-specialists scientists. We present a platform, SC2IT, that enables seamless control of virtual compute clusters in the Amazon EC2 cloud and is designed to be embedded in user-friendly Java GUIs. Thus users can create powerful High-Performance Computing systems with preconfigured MS codes in the cloud with a single mouse click. We present applications of our SCC platform to the materials science codes FEFF9, WIEN2k, and MEEP-mpi. SC2IT and the paradigm described here are applicable to other fields of research beyond materials science, although the computational performance of Cloud Computing may vary with the characteristics of the calculations.

  18. Block-Iterative Frequency-Domain Equalizations for SC-IDMA Systems

    Directory of Open Access Journals (Sweden)

    Salah Awad Salman

    2015-07-01

    Full Text Available In wireless broadband communications using single-carrier interleave division multiple access (SC-IDMA systems, efficient multiuser detection (MUD classes that make use of joint hybrid decision feedback equalization (HDFE/ frequency decision-feedback equalization (FDFE and interference cancellation (IC techniques, are proposed in conjunction with channel coding to deal with several users accessing the multipath fading channels. In FDFE-IDMA, the feedforward (FF and feedback (FB filtering operations of FDFE, which use to remove intersymbol interference (ISI, are implemented by Fast Fourier Transforms (FFTs, while in HDFE-IDMA the only FF filter is implemented by FFTs. Further, the parameters involved in the FDFE/HDFE filtering are derived according to the minimum mean square error (MMSE criteria, and the feedback symbol decisions are directly designed from soft detection of the decoded signals at the previous iteration. The simulation results including comparisons with those of frequency domain equalization (FDE, SC-FDE-IDMA and multi-carrier OFDM-IDMA schemes, with cyclic prefixing (CP and zero padding (ZP techniques, show that the combination of FDFE-IC/HDFE-IC provides an efficient solution with good performance for IDMA systems in ISI channels. Moreover, these iterative structures with block equalization yield a much lower complexity than equivalent existing structures, making them attractive for a wealth of applications.

  19. Functional expression of an scFv on bacterial magnetic particles by in vitro docking

    Energy Technology Data Exchange (ETDEWEB)

    Sugamata, Yasuhiro; Tanaka, Tsuyoshi; Matsunaga, Tadashi; Yoshino, Tomoko, E-mail: y-tomoko@cc.tuat.ac.jp

    2014-02-28

    Highlights: • We present a novel expression system called “in vitro docking” on bacterial magnetic particles. • An scFv–Fc was functionally expressed on bacterial magnetic particles of magnetotactic bacteria. • Our novel expression system on BacMPs will be effective for disulfide-bonded proteins. - Abstract: A Gram-negative, magnetotactic bacterium, Magnetospirillum magneticum AMB-1 produces nano-sized magnetic particles (BacMPs) in the cytoplasm. Although various applications of genetically engineered BacMPs have been demonstrated, such as immunoassay, ligand–receptor interaction or cell separation, by expressing a target protein on BacMPs, it has been difficult to express disulfide-bonded proteins on BacMPs due to lack of disulfide-bond formation in the cytoplasm. Here, we propose a novel dual expression system, called in vitro docking, of a disulfide-bonded protein on BacMPs by directing an immunoglobulin Fc-fused target protein to the periplasm and its docking protein ZZ on BacMPs. By in vitro docking, an scFv–Fc fusion protein was functionally expressed on BacMPs in the dimeric or trimeric form. Our novel disulfide-bonded protein expression system on BacMPs will be useful for efficient screening of potential ligands or drugs, analyzing ligand–receptor interactions or as a magnetic carrier for affinity purification.

  20. Biotypes and ScM types of isolates of Streptococcus canis from diseased and healthy cats.

    Science.gov (United States)

    Timoney, J F; Velineni, S; Ulrich, B; Blanchard, P

    2017-04-08

    Lancefield group G Streptococcus canis is a component of the normal urogenital and pharyngeal flora of the cat. It is also frequently implicated in epizootics of severe disease in closed cat colonies and animal shelters. Given the importance of S canis as a feline pathogen and relative lack of published information on characteristics potentially associated with virulence, the authors have compared isolates from healthy and diseased cats in New York and California using fermentation profiles (biotype) and ScM sequences. With few exceptions, isolates associated with disease were biotype 1. Four alleles of scm were identified of which type 1 dominated in diseased cats. Type 4 allelic variants were found only in healthy cats and all but one were biotype 2. Type 2 and 3 alleles showed extensive N-terminal variation suggesting a plasminogen-binding site as found on the type 1 allele was absent. Cat antisera to ScM were opsonobactericidal, and these potentially protective antibodies increased during convalescence. British Veterinary Association.

  1. HUBUNGAN PARITAS DAN RIWAYAT SC DENGAN KEJADIAN PLACENTA PREVIA DI RSUD ARIFIN ACHMAD PEKANBARU

    Directory of Open Access Journals (Sweden)

    wan anita

    2017-02-01

    Full Text Available Penyebab angka kematian ibu (AKI yang utama adalah perdarahan, dimana perdarahan yang sering terjadi pada ibu hamil salah satunya adalah plasenta previa. Plasenta previa adalah plasenta yang letaknya abnormal, yaitu pada segmen bawah uterus sehingga menutupi sebagian atau seluruh pembukaan jalan lahir. Penelitian ini dilakukan karena masih tingginya angka plasenta previa di RSUD Arifin Achmad Pekanbaru, yaitu 135 kasus tahun 2013. Tujuan penelitian ini untuk mengetahui hubungan paritas dan riwayat SC dengan kejadian plasenta previa pada ibu bersalin di ruang Camar I RSUD Arifin Achmad Pekanbaru. Desain penelitian adalah analitik kuantitatif dengan pendekatan cross sectional. Sampel adalah  ibu bersalin yang mengalami plasenta previa tahun 2013 yang berjumlah 135 kasus. Teknik pengambilan sampel ini total sampling. Analisis yang digunakan adalah analisis univariat dengan distribusi frekuensi dan analisis bivariat dengan uji chi square. Hasil penelitian menunjukkan terdapat hubungan paritas 1 dan >3 terhadap kejadian placenta previa (p value = 0,034 dan tidak terdapat hubungan ada riwayat SC dengan  kejadian placenta previa (p value = 0,052. Dari hasil penelitian dapat disarankan untuk menurunkan insiden plasenta previa diharapkan kepada petugas kesehatan untuk memberikan informasi tentang pentingnya merencanakan kehamilan yang aman dan ibu hamil untuk selalu memeriksakan kehamilan untuk melihat perkembangan kehamilannya.

  2. Structure and conductivity of the NASICON analog Na3SC2(PO4)3

    International Nuclear Information System (INIS)

    Susman, S.; Delbecq, C.J.; Brun, T.O.; Prince, E.

    1982-01-01

    Neutron and x-ray diffraction data of Na 3 SC 2 (PO 4 ) 3 are presented that show the transition from an ordinary-conducting, high temperature phase to a still higher temperature, superionic conducting phase. There are at least four polymorphic modifications. At room temperature, the refined neutron diffraction data confirm the Cc space group reported by Efremov and Kalinin but with a = 16.0449(24), b = 8.9225(15), c = 9.0656(13)A, #betta# = 126.918(21), R/sub weighted pattern/ = 17.5%, and R/sub expected/ = 7%. Between 25 0 C and 64 0 C, a second polymorph appears. The structure is monoclinic but has not yet been refined. At 64 0 C, a third polymorph C appears. It is rhombohedral R3c. Using hexagonal axes, a = 8.9273(2), c = 22.3668A, R/sub wp/ = 6.28% and R/sub e/ = 3.83% at 100 0 C. At 166 0 C, the high temperature polymorph D appears. It is the superconducting phase of NASICON(Sc). It, too, is rhombohedral R3c with a = 8.9274(1), c = 22.5493(6)A, R/sub wp/ = 5.81% and R/sub e/ = 3.87% at 225 0 C. The diffraction data are correlated with ionic conductivity measurements as a function of temperature

  3. Electronic, structural, and elastic properties of metal nitrides XN (X = Sc, Y): A first principle study

    Science.gov (United States)

    Ekuma, Chinedu E.; Bagayoko, Diola; Jarrell, Mark; Moreno, Juana

    2012-09-01

    We utilized a simple, robust, first principle method, based on basis set optimization with the BZW-EF method, to study the electronic and related properties of transition metal mono-nitrides: ScN and YN. We solved the KS system of equations self-consistently within the linear combination of atomic orbitals (LCAO) formalism. It is shown that the band gap and low energy conduction bands, as well as elastic and structural properties, can be calculated with a reasonable accuracy when the LCAO formalism is used to obtain an optimal basis. Our calculated, indirect electronic band gap (E^Γ -X_g) is 0.79 (LDA) and 0.88 eV (GGA) for ScN. In the case of YN, we predict an indirect band gap (E^Γ -X_g) of 1.09 (LDA) and 1.15 eV (GGA). We also calculated the equilibrium lattice constants, the bulk moduli (Bo), effective masses, and elastic constants for both systems. Our calculated values are in excellent agreement with experimental ones where the latter are available.

  4. Electronic, structural, and elastic properties of metal nitrides XN (X = Sc, Y: A first principle study

    Directory of Open Access Journals (Sweden)

    Chinedu E. Ekuma

    2012-09-01

    Full Text Available We utilized a simple, robust, first principle method, based on basis set optimization with the BZW-EF method, to study the electronic and related properties of transition metal mono-nitrides: ScN and YN. We solved the KS system of equations self-consistently within the linear combination of atomic orbitals (LCAO formalism. It is shown that the band gap and low energy conduction bands, as well as elastic and structural properties, can be calculated with a reasonable accuracy when the LCAO formalism is used to obtain an optimal basis. Our calculated, indirect electronic band gap (EΓ−Xg is 0.79 (LDA and 0.88 eV (GGA for ScN. In the case of YN, we predict an indirect band gap (EΓ−Xg of 1.09 (LDA and 1.15 eV (GGA. We also calculated the equilibrium lattice constants, the bulk moduli (Bo, effective masses, and elastic constants for both systems. Our calculated values are in excellent agreement with experimental ones where the latter are available.

  5. PrP N-terminal domain triggers PrP(Sc)-like aggregation of Dpl.

    Science.gov (United States)

    Erlich, Paul; Cesbron, Jean-Yves; Lemaire-Vieille, Catherine; Curt, Aurélie; Andrieu, Jean-Pierre; Schoehn, Guy; Jamin, Marc; Gagnon, Jean

    2008-01-18

    Transmissible spongiform encephalopathies are fatal neurodegenerative disorders thought to be transmitted by self-perpetuating conformational conversion of a neuronal membrane glycoprotein (PrP(C), for "cellular prion protein") into an abnormal state (PrP(Sc), for "scrapie prion protein"). Doppel (Dpl) is a protein that shares significant biochemical and structural homology with PrP(C). In contrast to its homologue PrP(C), Dpl is unable to participate in prion disease progression or to achieve an abnormal PrP(Sc)-like state. We have constructed a chimeric mouse protein, composed of the N-terminal domain of PrP(C) (residues 23-125) and the C-terminal part of Dpl (residues 58-157). This chimeric protein displays PrP-like biochemical and structural features; when incubated in presence of NaCl, the alpha-helical monomer forms soluble beta-sheet-rich oligomers which acquire partial resistance to pepsin proteolysis in vitro, as do PrP oligomers. Moreover, the presence of aggregates akin to protofibrils is observed in soluble oligomeric species by electron microscopy.

  6. The ASCI Network for SC 2000: Gigabyte Per Second Networking; TOPICAL

    International Nuclear Information System (INIS)

    PRATT, THOMAS J.; NAEGLE, JOHN H.; MARTINEZ JR., LUIS G.; HU, TAN CHANG; MILLER, MARC M.; BARNABY, MARTY L.; ADAMS, ROGER L.; KLAUS, EDWARD J.

    2001-01-01

    This document highlights the Discom's Distance computing and communication team activities at the 2000 Supercomputing conference in Dallas Texas. This conference is sponsored by the IEEE and ACM. Sandia's participation in the conference has now spanned a decade, for the last five years Sandia National Laboratories, Los Alamos National Lab and Lawrence Livermore National Lab have come together at the conference under the DOE's ASCI, Accelerated Strategic Computing Initiatives, Program rubric to demonstrate ASCI's emerging capabilities in computational science and our combined expertise in high performance computer science and communication networking developments within the program. At SC 2000, DISCOM demonstrated an infrastructure. DISCOM2 uses this forum to demonstrate and focus communication and pre-standard implementation of 10 Gigabit Ethernet, the first gigabyte per second data IP network transfer application, and VPN technology that enabled a remote Distributed Resource Management tools demonstration. Additionally a national OC48 POS network was constructed to support applications running between the show floor and home facilities. This network created the opportunity to test PSE's Parallel File Transfer Protocol (PFTP) across a network that had similar speed and distances as the then proposed DISCOM WAN. The SCINET SC2000 showcased wireless networking and the networking team had the opportunity to explore this emerging technology while on the booth. This paper documents those accomplishments, discusses the details of their convention exhibit floor. We also supported the production networking needs of the implementation, and describes how these demonstrations supports DISCOM overall strategies in high performance computing networking

  7. Characterization of semi-solid processing of aluminium alloy 7075 with Sc and Zr additions

    Energy Technology Data Exchange (ETDEWEB)

    Rogal, Ł., E-mail: l.rogal@imim.pl [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Dutkiewicz, J. [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Atkinson, H.V. [The University of Leicester, Department of Engineering University Road, Leicester, LE1 7RH (United Kingdom); Lityńska-Dobrzyńska, L.; Czeppe, T. [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Modigell, M. [RWTH Aachen—Department of Mechanical Process Engineering, 55 Templergraben St., Aachen (Germany)

    2013-09-15

    For thixoforming (semi-solid processing) it is necessary to have a fine globular microstructure in a semi-solid range. Here this has been obtained for 7075 aluminium alloy by addition of modifying agents: 0.5 weight % of scandium and zirconium. The thixoforming process was carried out at 632 °C which gave about 23 volume % of liquid phase. The microstructure of the thixo-formed part (a rotor) consisted of globular grains surrounded by precipitates of secondary phase. The average hardness of thixo-formed parts was 105 HV{sub 5} and the tensile strength 300 MPa. T6 heat treatments were performed with solutionisation at 450 °C for 30 min and 10 h. In both cases the ageing time was set as 18 h at 120 °C. The heat treatments led to an increase in average tensile strength up to 495 MPa. Transmission Electron Microscopy (TEM) analysis enabled the identification of precipitates of the metastable dispersoids of L1{sub 2}–Al{sub 3} (Zr, Sc) and η′ (MgZn{sub 2}) phases in the alloy after the thixoforming and T6 treatment. The measurements of rheological properties of 7075Al alloy with Sc and Zr additions in the semi-solid range indicated an increase of particle size and spheroidization leading to an observable decrease of viscosity during isothermal shearing. A shear rate jump experiment showed that with increasing shear rate the viscosity rapidly falls.

  8. Natural Diet of Callinectes ornatus Ordway, 1863 (Decapoda, Portunidae in the Itapocoroy Inlet, Penha, SC, Brazil

    Directory of Open Access Journals (Sweden)

    Joaquim Olinto Branco

    2002-03-01

    Full Text Available From January to December 1995, 332 individuals of the Callinectes ornatus species were collected from the Itapocoroy inlet in Penha, Sta. Catarina, Brazil to study its natural diet and the seasonal variations of diet. Results showed a diversified trophic spectrum with a generalized dietary strategy comprising the algae, macrophyta, foraminiferida, mollusca, polychaeta, crustacea, echinodermata, Osteichthyes and NIOM (Nonidentified Organic Matter groups.Alimentação natural de Callinectes ornatus Ordway, 1863 (Decapoda, Portunidae na Armação do Itapocoroy, Penha, SC - Brasil. No período de janeiro a dezembro de 1995, foram coletados 332 indivíduos de Callinectes ornatus, procedentes da Armação do Itapocoroy (Penha, SC. Foi estudada a alimentação natural da espécie e as variações sazonais da dieta. Os resultados mostram um espectro trófico diversificado, com estratégia alimentar generalista, sendo Algas, Macrófitas, Foraminiferida, Mollusca, Polychaeta, Crustacea, Echinodermata, Osteichthyes e matéria orgânica não identificada, os grupos que compõem sua dieta.

  9. Virtual microscopy in medical research: Open European Nephrology Science Center (OpEN.SC)

    Science.gov (United States)

    Schrader, Thomas; Beil, Michael; Schmidt, Danilo; Dietel, Manfred; Lindemann, Gabriela

    2007-03-01

    The amount and heterogeneity of data in biomedical research, notably in transnational research, requires new methods for the collection, presentation and analysis of information. Important data from laboratory experiments as well as patient trials are available as images. Thus, the integration and processing of image data represent a crucial component of information systems in biomedical research. The Charité Medical School in Berlin has established a new information service center for kidney diseases and transplantation (Open European Nephrology Science Centre - OpEN.SC) together with the German Research Agency (DFG). The aims of this project are (i) to improve the availability of raw data, (ii) to establish an infrastructure for clinical trials, (iii) to monitor the occurrence of rare disease patterns and (iv) to establish a quality assurance system. Major diagnostic procedures in medicine are based on the processing and analysis of image data. In diagnostic pathology, the availability of automated slide scanners provide the opportunity to digitize entire microscopic slides. The processing, presentation and analysis of these image data are called virtual microscopy. The integration of this new technology into the OpEN.SC system and the link to other heterogeneous data of individual patients represent a major technological challenge. Thus, new ways in communication between clinical and scientific partners have to be established and will be promoted by the project. The technological basis of the repository are web services for a scalable and adaptable system. HL7 and DICOM are considered the main medical standards of communication.

  10. Generalized magnetic susceptibilities in metals: application of the analytic tetrahedron linear energy method to Sc

    International Nuclear Information System (INIS)

    Rath, J.; Freeman, A.J.

    1975-01-01

    A detailed study of the generalized susceptibility chi(vector q) of Sc metal determined from an accurate augmented-plane-wave method calculation of its energy-band structure is presented. The calculations were done by means of a computational scheme for chi(vector q) derived as an extension of the work of Jepsen and Andersen and Lehmann and Taut on the density-of-states problem. The procedure yields simple analytic expressions for the chi(vector q) integral inside a tetrahedral microzone of the Brillouin zone which depends only on the volume of the tetrahedron and the differences of the energies at its corners. Constant-matrix-element results have been obtained for Sc which show very good agreement with the results of Liu, Gupta, and Sinha (but with one less peak) and exhibit a first maximum in chi(vector q) at (0, 0, 0.31) 2π/c [vs (0, 0, 0.35) 2π/c obtained by Liu et al.] which relates very well to dilute rare-earth alloy magnetic ordering at vector q/sub m/ = (0, 0, 0.28) 2π/c and to the kink in the LA-phonon dispersion curve at (0, 0, 0.27) 2π/c. (U.S.)

  11. Training Relations

    DEFF Research Database (Denmark)

    Smith, Aja

    This thesis explores the phenomenon of horse-assisted leadership training and the manners, in which the training relations between horses, managers and facilitators were entangled with perceptions of, what “proper sociality” entailed and felt like in contemporary Danish society. The study...... managers, horses and facilitators were training to strike between self-centredness and other-orientation, self-interests and fellow-feelings, was related to this marriage. The thesis contributes to the conceptualisation of the relationship between the self and sociality, particularly within consumer...... culture research interested in destabilising the primacy of the agentive powers of the human consumer. It does so by broadening the notion of the social to include animals – and by emphasising the sensorial, bodily and affective dimensions of the relations between self and sociality. A related...

  12. French Training

    CERN Multimedia

    Françoise Benz

    2003-01-01

    General and Professional French Courses The next session will take place: from 13 October to 19 December 2003. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages or contact Mrs. Fontbonne: Tel. 72844. Writing Professional Documents in French This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registration, please consult our Web pages or contact Mrs. Fontbonne: Tel. 72844. Language Training Françoise Benz Tel.73127 language.training@cern.ch

  13. Mapping lithosphere thickness beneath China with ScS reverberation data: what controls the intraplate seismicity in Mainland China

    Science.gov (United States)

    Niu, F.

    2011-12-01

    China is a country with high levels of seismic activity, and has a history of strong earthquakes that caused great loss in both life and property. While it is generally believed that the high seismicity is the result of the prolonged collision between India and Eurasia plates in the west, and the continuous rollback of the Pacific subduction in the east, there are, however, no quantitative explanations on the distribution of the observed seismicity. In this study, we intend to seek a possible relationship between the seismicity and lithospheric structure at large scale (~100km). We developed a new method that uses ScS reverberation data from deep earthquakes to image the lithosphere and asthenosphere boundary (LAB). More specifically, we used more than 600 CEArray records (The CEArray consists of 31 regional networks operated by the China Earthquake Administration (CEA)) from a large deep earthquake occurring beneath the Sea of Okhotsk on July 5 of 2008. Multiple reflections of SH waves between the free surface and the core-mantle boundary (ScS1, ScS2, ScS3) can be clearly identified from all the individual records. We used the upperside reflections at the LAB (ScSm_SdS), which arrive after the main ScS multiples (ScSm), to estimate the depth of the boundary. We employed a common-reflection-point (CRP) stacking technique to the ScS reverberation data to enhance the signal-to-noise ratio (SNR) of the LAB reflections. At an assuming LAB depth, d, for each source-receiver pair, we first computed the reflection points of ScSm_SdS and the time moveouts of the ScSm_SdS with respect to ScSm by ray tracing the iasp91 velocity model. We further included corrections computed from 3D crustal and mantle velocity models. We divided the study area (18°N to 54°N, 75°E to 134°E) into meshed grid of 1° by 1°, and used a circular cap with a radius of 1 degree for gathering the ScS reverberations. We then summed all the reverberation data within a 0.5 s window centered on the

  14. Experimental, numerical, and analytical studies on the seismic response of steel-plate concrete (SC) composite shear walls

    Science.gov (United States)

    Epackachi, Siamak

    The seismic performance of rectangular steel-plate concrete (SC) composite shear walls is assessed for application to buildings and mission-critical infrastructure. The SC walls considered in this study were composed of two steel faceplates and infill concrete. The steel faceplates were connected together and to the infill concrete using tie rods and headed studs, respectively. The research focused on the in-plane behavior of flexure- and flexure-shear-critical SC walls. An experimental program was executed in the NEES laboratory at the University at Buffalo and was followed by numerical and analytical studies. In the experimental program, four large-size specimens were tested under displacement-controlled cyclic loading. The design variables considered in the testing program included wall thickness, reinforcement ratio, and slenderness ratio. The aspect ratio (height-to-length) of the four walls was 1.0. Each SC wall was installed on top of a re-usable foundation block. A bolted baseplate to RC foundation connection was used for all four walls. The walls were identified to be flexure- and flexure-shear critical. The progression of damage in the four walls was identical, namely, cracking and crushing of the infill concrete at the toes of the walls, outward buckling and yielding of the steel faceplates near the base of the wall, and tearing of the faceplates at their junctions with the baseplate. A robust finite element model was developed in LS-DYNA for nonlinear cyclic analysis of the flexure- and flexure-shear-critical SC walls. The DYNA model was validated using the results of the cyclic tests of the four SC walls. The validated and benchmarked models were then used to conduct a parametric study, which investigated the effects of wall aspect ratio, reinforcement ratio, wall thickness, and uniaxial concrete compressive strength on the in-plane response of SC walls. Simplified analytical models, suitable for preliminary analysis and design of SC walls, were

  15. Enhancement of Dielectric Breakdown Strength and Energy Conversion Efficiency of Niobate Glass-Ceramics by Sc2O3 Doping

    Science.gov (United States)

    Xiao, Shi; Xiu, Shaomei; Yang, Ke; Shen, Bo; Zhai, Jiwei

    2018-01-01

    Niobate glass-ceramics K2O-SrO-Nb2O5-B2O3-Al2O3-SiO2 (KSN-BAS) doped with different amounts of Sc2O3 have been prepared through a melt quenching/controlled crystallization method, and the influence of the Sc2O3 content on their phase composition, microstructure, dielectric performance, and charge-discharge properties investigated. X-ray powder diffraction results showed that the peak positions of the KSr2Nb5O15 phase shifted to higher angle and the glass-ceramic microstructures were significantly improved by Sc2O3 addition. Based on these results, 0.5 mol.% Sc2O3 doping was found to achieve remarkable enhancement in energy storage density, which reached 9.63 ± 0.39 J/cm3 at dielectric breakdown strength of 1450.38 ± 29.01 kV/cm with high conversion efficiency of ˜ 92.1%. For pulsed power applications, discharge speed of 17 ns and power density of 0.48 MW/cm3 were obtained in the glass-ceramic with 0.5 mol.% Sc2O3. These results could provide a new design strategy for high-performance dielectric capacitors.

  16. Development of a sensitive nested PCR method for the specific detection of Mycoplasma mycoides subsp. mycoides SC.

    Science.gov (United States)

    Miserez, R; Pilloud, T; Cheng, X; Nicolet, J; Griot, C; Frey, J

    1997-04-01

    A specific and sensitive test for the detection of Mycoplasma mycoides subsp. mycoides small colony type (SC), the aetiological agent of contagious bovine pleuropneumonia (CBPP) was developed using two nested PCR reactions. The PCR reactions are based on the nucleotide sequence of lipoprotein P72 of M. mycoides subsp. mycoides SC. The two specific oligonucleotide primer pairs were chosen to match those sequence segments of the P72 gene which differ most from the gene of the closely related lipoprotein P67 of Mycoplasma sp. bovine group 7 (strain PG50). The nested PCR reacted with all of the 34 different strains of M. mycoides subsp. mycoides SC analysed, and gave no amplification product with any of the closely related mycoplasmas tested, showing its high specificity. In bronchial lavage fluid experimentally contaminated with M. mycoides subsp. mycoides SC, the assay was able to detect as few as two viable cells per ml using a simple lysis procedure prior to the amplification step. With clinical samples, the sensitivity of the nested PCR was about 10(4)-10(5) higher than that of single PCR amplifications performed under the same conditions. The assay was also successfully used to detect M. mycoides subsp. mycoides SC in bronchial lavage fluid of experimentally infected cattle and proved to be more sensitive than classical culture methods.

  17. scFv from Antibody That Mimics gp43 Modulates the Cellular and Humoral Immune Responses during Experimental Paracoccidioidomycosis.

    Science.gov (United States)

    Jannuzzi, Grasielle Pereira; Tavares, Aldo Henrique F P; Kaihami, Gilberto Hideo; de Almeida, José Roberto Fogaça; de Almeida, Sandro Rogério; Ferreira, Karen Spadari

    2015-01-01

    Paracoccidioidomycosis (PCM), caused by Paracoccidioides species is a prevalent systemic and progressive mycosis that occurs in Latin America. It is caused by Paracoccidioides species. Immunization with dendritic cells transfected with a plasmid encoding the scFv (pMAC/PS-scFv) that mimics the main antigen of P. brasiliensis (gp43) confers protection in experimental PCM. DCs link innate and adaptive immunity by recognizing invading pathogens and selecting the type of effector T cell to mediate the immune response. Here, we showed that DC-pMAC/PS-scFv induces the activation of CD4+ and CD8+ T cells. Moreover, our results demonstrated that BALB/c mice infected with P. brasiliensis and treated with DC-pMAC/PS-scFv showed the induction of specific IgG production against gp43 and IFN-γ, IL-12 and IL-4 cytokines. Analysis of regional lymph nodes revealed increases in the expression of clec7a, myd88, tlr2, gata3 and tbx21, which are involved in the immune response. Taken together, our results indicate that the scFv modulates the humoral and cellular immune responses and presents epitopes to CD4+ and CD8+ T cells.

  18. Construction and sequencing analysis of scFv antibody fragment derived from monoclonal antibody against norfloxacin (Nor155

    Directory of Open Access Journals (Sweden)

    J. Mala

    2017-06-01

    Full Text Available Norfloxacin belongs to the group of fluoroquinolone antibiotics which has been approved for treatment in animals. However, its residues in animal products can pose adverse side effects to consumer. Therefore, detection of the residue in different food matrices must be concerned. In this study, a single chain variable fragment (scFv that recognizes norfloxacin antibiotic was constructed. The cDNA was synthesized from total RNA of hybridoma cells against norfloxacin. Genes encoding VH and VL regions of monoclonal antibody against norfloxacin (Nor155 were amplified and size of VH and VL fragments was 402 bp and 363 bp, respectively. The scFv of Nor155 was constructed by an addition of (Gly4Ser3 as a linker between VH and VL regions and subcloned into pPICZαA, an expression vector of Pichia pastoris. The sequence of scFv Nor155 (GenBank No. AJG06891.1 was confirmed by sequencing analysis. The complementarity determining regions (CDR I, II, and III of VH and VL were specified by Kabat method. The obtained recombinant plasmid will be useful for production of scFv antibody against norfloxacin in P. pastoris and further engineer scFv antibody against fluoroquinolone antibiotics.

  19. Construction of a Single Chain Variable Fragment Antibody (scFv) against Carbaryl and Its Interaction with Carbaryl.

    Science.gov (United States)

    Xiuyuan, Zhang; Zhihong, Huang; Lixia, Wang; Xiaonan, Liu

    2015-05-01

    Carbaryl is a low molecular weight insecticide that inhibits cholinesterase. Residues of carbaryl in food and the environment have damaged human health. A high-specificity scFv that can identify carbaryl is still lacking. In the present study, an anti-carbaryl scFv gene was prepared by cloning VL and VH genes from hybridoma cells secreting monoclonal antibody, then VH and VL were fused together using splicing by overlap extension (SOE) PCR with a flexible polypeptide linker connector (Gly4Ser)3, and then the scFv-pET-26b recombinant plasmid was constructed and transformed into E. coli BL21 for expression using IPTG as an inducer. The expressed recombinant protein was identified by SDS-PAGE and ELISA. The three-dimensional structure of the anti-carbaryl scFv was constructed by computer modeling, and carbaryl was docked to the scFv model to obtain the structure of the binding complex. The binding site was composed of Ala51, Ser52, Ile51, Gly54, Ser56, Arg98, and Gly100. This helps to understand the mechanism of interaction between anti-carbaryl antibody and antigen. Furthermore, it provides guidance for in vitro affinity maturation of anti-carbaryl antibody.

  20. Process boundaries of irreversible scCO2 -assisted phase separation in biphasic whole-cell biocatalysis.

    Science.gov (United States)

    Brandenbusch, Christoph; Glonke, Sebastian; Collins, Jonathan; Hoffrogge, Raimund; Grunwald, Klaudia; Bühler, Bruno; Schmid, Andreas; Sadowski, Gabriele

    2015-11-01

    The formation of stable emulsions in biphasic biotransformations catalyzed by microbial cells turned out to be a major hurdle for industrial implementation. Recently, a cost-effective and efficient downstream processing approach, using supercritical carbon dioxide (scCO2 ) for both irreversible emulsion destabilization (enabling complete phase separation within minutes of emulsion treatment) and product purification via extraction has been proposed by Brandenbusch et al. (2010). One of the key factors for a further development and scale-up of the approach is the understanding of the mechanism underlying scCO2 -assisted phase separation. A systematic approach was applied within this work to investigate the various factors influencing phase separation during scCO2 treatment (that is pressure, exposure of the cells to CO2 , and changes of cell surface properties). It was shown that cell toxification and cell disrupture are not responsible for emulsion destabilization. Proteins from the aqueous phase partially adsorb to cells present at the aqueous-organic interface, causing hydrophobic cell surface characteristics, and thus contribute to emulsion stabilization. By investigating the change in cell-surface hydrophobicity of these cells during CO2 treatment, it was found that a combination of catastrophic phase inversion and desorption of proteins from the cell surface is responsible for irreversible scCO2 mediated phase separation. These findings are essential for the definition of process windows for scCO2 -assisted phase separation in biphasic whole-cell biocatalysis. © 2015 Wiley Periodicals, Inc.

  1. Comparative study of Tm-doped and Tm-Sc co-doped Lu3Al5O12 scintillator

    International Nuclear Information System (INIS)

    Sugiyama, Makoto; Yanagida, Takayuki; Fujimoto, Yutaka

    2014-01-01

    The crystals of Tm doped and Tm-Sc co-doped Lu 3 Al 5 O 12 (LuAG) grown by the floating zone (FZ) method were examined for their optical and scintillation properties. In transmittance spectra, strong absorption lines due to Tm 3+ 4f–4f transitions were observed. X-ray excited radioluminescence spectra were measured and broad and sharp emission peaks were detected. The former one was attributed to Sc 3+ and the latter one was due to Tm 3+ 4f–4f transitions. Scintillation yield enhancement due to Sc co-doping was observed by means of 137 Cs pulse height spectra. Scintillation decay times were several tens of μs under pulse X-ray excitation. - Highlights: • LuAG:Tm and LuAG:Tm, Sc single crystals have been grown by the FZ method. • Tm 3+ 4f–4f absorption has been observed in transmittance spectra. • Scintillation yield of Tm-doped LuAG has been enhanced by Sc co-doping

  2. Supervisor training

    DEFF Research Database (Denmark)

    Pedersen, Inge Nygaard

    2015-01-01

    on the experience of an integrated supervisor training programme offered in Aalborg, Denmark in 2009/2010. In this programme general issues of professional supervision and the application of artistic media as a core element in the supervisory process were Integrated. It is the hope of the author that this article...

  3. Interval Training.

    Science.gov (United States)

    President's Council on Physical Fitness and Sports, Washington, DC.

    Regardless of the type of physical activity used, interval training is simply repeated periods of physical stress interspersed with recovery periods during which activity of a reduced intensity is performed. During the recovery periods, the individual usually keeps moving and does not completely recover before the next exercise interval (e.g.,…

  4. Language training

    CERN Multimedia

    Françoise Benz

    2006-01-01

    If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training'form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received. General and Professional English Courses The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).These courses are open to all persons working on the CERN site and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Tessa Osborne, tel.16 23 40. Oral Expression The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).This course is intended for people with a goo...

  5. Language training

    CERN Document Server

    2006-01-01

    If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received. General and Professional English Courses The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).These courses are open to all persons working on the CERN site and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Tessa Osborne, tel.16 23 40. Oral Expression The next session will take place from beginning of October 2006 to beginning of February 2007 (3 weeks break at Christmas).This course is intended for people with a good knowl...

  6. Language Training

    CERN Multimedia

    Françoise Benz

    2005-01-01

    If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received. General and Professional English Courses The next session will take place: from end of September 2005 to middle of February 2006 (2/ 3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957. Oral Expression The next session will take place from end of September to December 2005. This course is intended for people with a good knowledge of English who want to practise and maintain the...

  7. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Monday 9 February 2004 From 10:00 to 12:00 - IT Auditorium - bldg. 31, 3rd floor ANSOFT High-Frequency Seminar David Prestaux, Application Engineer, ANSOFT F-78535 BUC, France This Technical Training seminar will present two Ansoft application products: Ansoft HFSS and Ansoft Designer. Ansoft HFSS makes use of the Finite Element Method (FEM) to calculate field solutions from first principles. It can accurately predict all high-frequency behaviours such as dispersion, mode conversion, and losses due to materials and radiation. Ansoft Designer is a suite of design tools to fully integrate high-frequency, physics-based electromagnetic simulations into a seamless system-level simulation environment. Ansoft Designer uses a simple interface to give complete control over every design task, by a method allowing multiple solvers, Solver on Demand. • Introduction • Overview of the Ansoft Total solution • Ansoft HFSS 9...

  8. SoCIAL – training cognition in schizophrenia: a pilot study

    Directory of Open Access Journals (Sweden)

    Palumbo D

    2017-07-01

    Full Text Available Davide Palumbo,* Armida Mucci,* Giuseppe Piegari, Valentina D’Alise, Annapaola Mazza, Silvana Galderisi Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy *These authors contributed equally to this work Abstract: The purpose of this pilot study was to assess the efficacy of a new social cognition (SC remediation intervention, the Social Cognition Individualized Activities Lab (SoCIAL, for subjects with schizophrenia. The training includes a module for emotion recognition and one for theory of mind. A comparison with a validated cognitive remediation intervention, the Social Skills And Neurocognitive Individualized Training (SSANIT, was conducted to verify the efficacy of the SoCIAL in improving SC. Ten stabilized patients with schizophrenia accepted to participate. Five patients were randomized to SoCIAL and five to SSANIT. The SoCIAL intervention includes individual sessions of neurocognitive individualized training (NIT and group sessions of SC training. SSANIT includes individual sessions of NIT and group sessions of social skills individualized training. The interventions were matched for the overall treatment duration (20 weeks and for the frequency of the sessions (two times a week, one for SoCIAL or social skills individualized training and one for NIT, with a duration of 80 minutes for each session. Results showed a significant treatment effect (effect size: Cohen’s d 0.32 on the primary outcome; in fact, only the SoCIAL intervention improved theory of mind. Patients receiving the SoCIAL intervention also showed an improvement of avolition. These preliminary findings support further development of the SoCIAL and suggest that cognitive remediation should include an SC module. Keywords: cognitive remediation, psychiatric rehabilitation, negative symptoms, avolition, MATRICS consensus cognitive battery, MCCB

  9. New indides Sc{sub 6}Co{sub 2.18}In{sub 0.82}, Sc{sub 10}Ni{sub 9}In{sub 19.44} and ScCu{sub 4}In-synthesis, structure, and crystal chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Zaremba, R.I.; Rodewald, U. Ch.; Poettgen, R. [Inst. fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Univ. Muenster (Germany); Kalychak, Y.M.; Zaremba, V.I. [Inorganic Chemistry Dept., Ivan Franko National Univ. of Lviv, Lviv (Ukraine)

    2006-08-15

    New indides Sc{sub 6}Co{sub 2.18}In{sub 0.82}, Sc{sub 10}Ni{sub 9}In{sub 19.44} and ScCu{sub 4}In have been synthesized from the elements by arc-melting. Single crystals were grown by special annealing modes. The thee indides were investigated via X-ray powder and single crystal diffraction: Ho{sub 6}Co{sub 2}Ga type, Immm, a = 886.7(3), b = 878.0(2), c = 932.1(3) pm, wR2 = 0.0517, 711 F{sup 2} values, 35 variables for Sc{sub 6}Co{sub 2.18}In{sub 0.82}, Ho{sub 10}Ni{sub 9}In{sub 20} type, P4/nmm, a = 1287.5(2), c = 884.7(1) pm, wR2 = 0.0642, 1221 F{sup 2} values, 63 variables for Sc{sub 10}Ni{sub 9}In{sub 19.44}, and MgCu{sub 4}Sn type, anti F 43m, a = 704.03(7) pm, wR2 = 0.0267, 101 F{sup 2} values, and 7 variables for ScCu{sub 4}In. The scandium rich indide Sc{sub 6}Co{sub 2.18}In{sub 0.82} contains two Co{sub 2} dumb-bells at Co-Co distances of 221 and 230 pm. Each cobalt atom within these dumb-bells has a tricapped trigonal prismatic coordination. The In1 site has a distorted cube-like coordination by scandium and shows a mixed occupancy (36%) with cobalt. The In2 atoms have distorted icosahedral scandium coordination. As a consequence of the small size of the scandium atoms, the In4 site in Sc{sub 10}Ni{sub 9}In{sub 19.44} shows defects and was furthermore refined with a split model leading to a new distorted variant within the family of Ho{sub 10}Ni{sub 9}In{sub 20} compounds. ScCu{sub 4}In is an ordered version of the cubic Laves phase with scandium and indium atoms in the CN16 voids of the copper substructure. The Cu-Cu distances within the three-dimensional network of corner-sharing tetrahedra are 248.6 and 249.2 pm. The crystal chemical peculiarities of these three indide structures are briefly discussed. (orig.)

  10. Synthesis of Sc{sub 2}O{sub 3} powders for preparation of transparent ceramics; Synthese de poudres de Sc{sub 2}O{sub 3} destinees a l'elaboration d'une ceramique transparente

    Energy Technology Data Exchange (ETDEWEB)

    Bravo, A.C.; Longuet, L.; Autissier, D. [CEA Centre d' Etudes du Ripault, 37 - Tours (France); Baumard, J.F. [Laboratoire Science des Procedes Ceramiques et de Traitements de Surfaces, SPCTS, UMR CNRS 6638, 87 - Limoges (France)

    2007-07-01

    Different precursors have been prepared by precipitation from scandium nitrates salts using ammonium hydrogeno-carbonate as precipitating agent. The influence of the precipitation technique, of the preparation temperature and of the 'precipitating agent/Sc{sup 3+}' molar ratio on the characteristics (nature, grain size...) of the synthesized precursors has been observed. A heat treatment at 700 C of these precursors has allowed to obtain thin and homogeneous Sc{sub 2}O{sub 3} powders well adapted for transparent ceramics preparation. (O.M.)

  11. MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.

    Directory of Open Access Journals (Sweden)

    Marin IONICĂ

    2012-12-01

    Full Text Available Through this scientific research report “MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.” we plan to investigate the remuneration and stimulation method from the human resources department within S.C. Tasmania. Studying in detail the personnel’s remuneration and stimulation we have tried to present the main policy aspects at S.C. Tasmania in human resources domain: integration of the human resource management in the overall management of the company, creating a favorable climate for conducting the activities,professional development, evaluation and motivation, employee involvement in the decision making process.We conclude that the development of management theory and practice in personnel remuneration and stimulation in an open field for performance and professionalism of the managerial team of Tasmania S.R.L.

  12. High strength aluminum cast alloy: A Sc modification of a standard Al–Si–Mg cast alloy

    International Nuclear Information System (INIS)

    Muhammad, Arfan; Xu, Cong; Xuejiao, Wang; Hanada, Shuji; Yamagata, Hiroshi; Hao, LiRong; Chaoli, Ma

    2014-01-01

    A standard Aluminum–Silicon–Magnesium cast alloy (A357 foundry alloy without Beryllium) modified with different weight percentages of Scandium (Sc), has been studied to evaluate the effects of Sc contents on microstructure and strength. Study has been conducted under optimized parameters of melting, casting and heat treatment. Characterization techniques like optical microscopy, SEM, TEM and tensile testing were employed to analyze the microstructure and mechanical properties. Results obtained in this research indicate that with the increase of Sc contents up to 0.4 wt%, grain size is decreased by 80% while ultimate tensile strength and hardness are increased by 28% and 19% respectively. Moreover along with the increase in strength, elongation to failure is also increased up to 165%. This is quite interesting behavior because usually strength and ductility have inverse relationship

  13. Magnetism in Sc-doped ZnO with zinc vacancies: A hybrid density functional and GGA + U approaches

    KAUST Repository

    Kanoun, Mohammed

    2012-04-01

    We investigate the zinc vacancy effects on the electronic structures and magnetic properties of Sc-doped ZnO, by performing first-principles calculations within both GGA + U and Heyd-Scuseria-Ernzerhof hybrid functional methods. We find that Sc impurities stabilize considerably Zn vacancies. The electronic and magnetic analysis shows a half metallic ferromagnetic character with a total magnetic moment of 2.01 μ B. The magnetism mainly stems from the O 2p states around the Zn vacancies. Calculations with the hybrid density functional agree with the GGA + U results but give an accurate description of the electronic structure for pure ZnO and Sc-doped ZnO with Zn vacancies. © 2012 Elsevier B.V. All rights reserved.

  14. Detection and localisation of PrP(Sc in the liver of sheep infected with scrapie and bovine spongiform encephalopathy.

    Directory of Open Access Journals (Sweden)

    Sally J Everest

    Full Text Available Prions are largely contained within the nervous and lymphoid tissue of transmissible spongiform encephalopathy (TSE infected animals. However, following advances in diagnostic sensitivity, PrP(Sc, a marker for prion disease, can now be located in a wide range of viscera and body fluids including muscle, saliva, blood, urine and milk, raising concerns that exposure to these materials could contribute to the spread of disease in humans and animals. Previously we demonstrated low levels of infectivity in the liver of sheep experimentally challenged with bovine spongiform encephalopathy. In this study we show that PrP(Sc accumulated in the liver of 89% of sheep naturally infected with scrapie and 100% of sheep challenged with BSE, at both clinical and preclinical stages of the disease. PrP(Sc was demonstrated in the absence of obvious inflammatory foci and was restricted to isolated resident cells, most likely Kupffer cells.

  15. Intensive gait training in toddlers with cerebral palsy: A pilot study

    Directory of Open Access Journals (Sweden)

    Anna Herskind

    2016-07-01

    Full Text Available Background: Reduced muscle growth may be involved in the development of contractures in children with cerebral palsy (CP. Here, we report data from a pilot study of intensive gait training in CP toddlers. Methods: Five children with CP aged 8-30 months performed activity-based gait training for one hour/day, five days/week for three consecutive months. Included children were diagnosed with spastic CP, had a Gross Motor Function Classification System (GMFCS score of I–II, and were not epileptic. All children wore pedometers during training. Before and after the training period, kinematic and qualitative gait analysis, clinical and objective evaluation of spasticity, Gross Motor Function Measure-66 (GMFM-66, and ultrasound of the affected medial gastrocnemius (MG muscle were performed. Two children were also tested before and after three months of receiving only standard care (SC. Results: On average 1410 steps/session were logged during 63 days of training. More steps were achieved at home than at a central facility. During training, MG muscle volume increased significantly, while it decreased for SC children. Gait improved qualitatively in all children, and GMFM-66 score improved in four of the five children. Similar improvements were seen among the SC children. Two children had pathologically increased muscle stiffness prior to training, which was reduced during training. Reflex stiffness was unchanged in all five children. Conclusions: This pilot study suggests that intensive gait training may increase muscle volume, improve walking skills and reduce passive muscle stiffness in toddlers with CP.

  16. Development of Field-Controlled Smart Optic Materials (ScN, AlN) with Rare Earth Dopants

    Science.gov (United States)

    Kim, Hyun-Jung; Park, Yeonjoon; King, Glen C.; Choi, Sang H.

    2012-01-01

    The purpose of this investigation is to develop the fundamental materials and fabrication technology for field-controlled spectrally active optics that are essential for industry, NASA, and DOD applications such as: membrane optics, filters for LIDARs, windows for sensors, telescopes, spectroscopes, cameras, flat-panel displays, etc. ScN and AlN thin films were fabricated on c-axis Sapphire (0001) or quartz substrate with the RF and DC magnetron sputtering. The crystal structure of AlN in fcc (rocksalt) and hcp (wurtzite) were controlled. Advanced electrical characterizations were performed, including I-V and Hall Effect Measurement. ScN film has a free carrier density of 5.8 x 10(exp 20)/per cubic centimeter and a conductivity of 1.1 x 10(exp 3) per centimeter. The background ntype conductivity of as-grown ScN has enough free electrons that can readily interact with the photons. The high density of free electrons and relatively low mobility indicate that these films contain a high level of shallow donors as well as deep levels. Also, the UV-Vis spectrum of ScN and AlN thin films with rare earth elements (Er or Ho) were measured at room temperature. Their optical band gaps were estimated to be about 2.33eV and 2.24eV, respectively, which are obviously smaller than that of undoped thin film ScN (2.4eV). The red-shifted absorption onset gives direct evidence for the decrease of band gap (Eg) and the energy broadening of valence band states are attributable to the doping. As the doped elements enter the ScN crystal lattices, the localized band edge states form at the doped sites with a reduction of Eg. Using a variable angle spectroscopic ellipsometer, the decrease in refractive index with applied field is observed with a smaller shift in absorption coefficient.

  17. Thermoelectric properties of epitaxial ScN films deposited by reactive magnetron sputtering onto MgO(001) substrates

    Science.gov (United States)

    Burmistrova, Polina V.; Maassen, Jesse; Favaloro, Tela; Saha, Bivas; Salamat, Shuaib; Rui Koh, Yee; Lundstrom, Mark S.; Shakouri, Ali; Sands, Timothy D.

    2013-04-01

    Epitaxial ScN(001) thin films were grown on MgO(001) substrates by dc reactive magnetron sputtering. The deposition was performed in an Ar/N2 atmosphere at 2 × 10-3 Torr at a substrate temperature of 850 °C in a high vacuum chamber with a base pressure of 10-8 Torr. In spite of oxygen contamination of 1.6 ± 1 at. %, the electrical resistivity, electron mobility, and carrier concentration obtained from a typical film grown under these conditions by room temperature Hall measurements are 0.22 mΩ cm, 106 cm2 V-1 s-1, and 2.5 × 1020 cm-3, respectively. These films exhibit remarkable thermoelectric power factors of 3.3-3.5 × 10-3 W/mK2 in the temperature range of 600 K to 840 K. The cross-plane thermal conductivity is 8.3 W/mK at 800 K yielding an estimated ZT of 0.3. Theoretical modeling of the thermoelectric properties of ScN calculated using a mean-free-path of 23 nm at 300 K is in very good agreement with the experiment. These results also demonstrate that further optimization of the power factor of ScN is possible. First-principles density functional theory combined with the site occupancy disorder technique was used to investigate the effect of oxygen contamination on the electronic structure and thermoelectric properties of ScN. The computational results suggest that oxygen atoms in ScN mix uniformly on the N site forming a homogeneous solid solution alloy. Behaving as an n-type donor, oxygen causes a shift of the Fermi level in ScN into the conduction band without altering the band structure and the density of states.

  18. [Validation of a Spanish version of the Childhood Asthma Control Test (Sc-ACT) for use in Spain].

    Science.gov (United States)

    Pérez-Yarza, E G; Castro-Rodriguez, J A; Villa Asensi, J R; Garde Garde, J; Hidalgo Bermejo, F J

    2015-08-01

    The Childhood Asthma Control Test (c-ACT) is a validated tool for determining pediatric asthma control. However, it is not validated in the Spanish language in Spain. We evaluated the psychometric properties of the Spanish version of the Childhood Asthma Control Test (Sc-ACT) for assessing asthma control in children ages 4 to11. This national, multicentre, prospective study was conducted in Spain with asthmatic children and their caregivers. Patients were assessed at 3 visits (Baseline, 2 Weeks, and 4 Months). Clinical variables included: symptoms, exacerbations, FEV1, asthma classification, PAQLQ and PACQLQ questionnaire scores, and asthma control as perceived by physicians, patients and caregivers. The Sc-ACT feasibility, validity, reliability, and sensitivity to change were assessed. A total of 394 children were included; mean (SD) time to complete the Sc-ACT was 5.3 (4.4) minutes. Sc-ACT score was correlated with asthma control as perceived by physician (-0.52), patient (-0.53), and caregiver (-0.51) and with the PAQLQ (0.56) and PACQLQ (0.55) scores. Sc-ACT was found to be significantly related to intensity and frequency of asthma symptoms. Cronbach alpha coefficient α was 0.81 and intraclass correlation coefficient was ≥0.85 for all of the items. The global effect size of Sc-ACT was 0.55. The cutoff point scores of 21 or higher indicated a good asthma control and their MCID was 4 points. The Spanish version of the c-ACT was found to be a reliable and valid questionnaire for evaluating asthma control in Spanish-speaking children ages 4 to 11 in Spain. Copyright © 2014 Asociación Española de Pediatría. Published by Elsevier España, S.L.U. All rights reserved.

  19. Effect of Grain Refinement on Jerky Flow in an Al-Mg-Sc Alloy

    Science.gov (United States)

    Mogucheva, Anna; Yuzbekova, Diana; Kaibyshev, Rustam; Lebedkina, Tatiana; Lebyodkin, Mikhail

    2016-05-01

    The influence of microstructure on the manifestations of the Portevin-Le Chatelier (PLC) effect was studied in an Al-Mg-Sc alloy with unrecrystallized, partially recrystallized, and fully recrystallized grain structures. It was found that the extensive grain refinement promotes plastic instability: the temperature-strain rate domain of the PLC effect becomes wider and the critical strain for the onset of serrations decreases. Besides, the amplitude of regular stress serrations observed at room temperature and an intermediate strain rate increases several times, indicating a strong increase of the contribution of solute solution hardening to the overall strength. Moreover, the grain refinement affects the usual sequence of the characteristic types of stress serrations, which characterize the dynamical mechanisms governing a highly heterogeneous unstable plastic flow. Finally, it reduces the strain localization and surface roughness and diminishes the difference between the surface markings detected in the necked area and in the region of uniform elongation.

  20. Socioeconomic dynamic in market practices of family farmers Chapecó (SC

    Directory of Open Access Journals (Sweden)

    Hieda Maria Pagliosa Corona

    2018-01-01

    Full Text Available In this article the central objective is to understand the fair as a strategic space for the survival of family farming, going beyond the issue of market integration. Field research was conducted in two main fairs in the city of Chapeco/SC, divided into two stages: a study of the characteristics of the market traders, through the interview based on a form with open and closed questions 63 hawkers responsible posts; and interviews from semi-structured questions with 28 families, who met the exigencies of family farmers and are marketer Chapecó residents. The collected data are presented in tabular summaries and analysis followed the content analysis parameters. The results demonstrate the importance of local farmers market vendors not only as a space for marketing of products, but as a social construction of space that are current interconhecimento relations, reciprocity and the relative autonomy of the food hegemonic system.

  1. Microstructure and Mechanical Properties of an Al-Li-Mg-Sc-Zr Alloy Subjected to ECAP

    Directory of Open Access Journals (Sweden)

    Anna Mogucheva

    2016-10-01

    Full Text Available The effect of post-deformation solution treatment followed by water quenching and artificial aging on microstructure and mechanical properties of an Al-Li-Mg-Sc-Zr alloy subjected to equal-channel angular pressing (ECAP was examined. It was shown that the deformed microstructure produced by ECAP remains essentially unchanged under solution treatment. However, extensive grain refinement owing to ECAP processing significantly affects the precipitation sequence during aging. In the aluminum-lithium alloy with ultrafine-grained (UFG microstructure, the coarse particles of the S1-phase (Al2LiMg precipitate on high-angle boundaries; no formation of nanoscale coherent dispersoids of the δ′-phase (Al3Li occurs within grain interiors. Increasing the number of high-angle boundaries leads to an increasing portion of the S1-phase. As a result, no significant increase in strength occurs despite extensive grain refinement by ECAP.

  2. Effect of deformation structure on fatigue behavior of an Al-Mg-Sc alloy

    Science.gov (United States)

    Zhemchuzhnikova, Daria; Kaibyshev, Rustam

    2014-08-01

    Effect of initial grain size on fatigue behavior of an Al-6%Mg-0.35%Mn-0.2%Sc- 0.08%Zr-0.07%Cr alloy was examined. The initial CG microstructure with an average grain size of ~ 22 μm was manufactured by casting followed by solution treatment at 360 °C for 12 h. To produce the UFG condition, the alloy was subjected to equal-channel angular pressing (ECAP) at 320 °C up to a total strain of ~ 14. Extensive grain refinement provided the formation of fully recrystallized structure with an average grain size of 700 nm. It was shown that the formation of UFG structure provided +60% increases in yield stress and +25% increases in fatigue strength. Fundamentals of this effect of microstructure on the static strength, fatigue resistance and fracture modes are discussed.

  3. Fusion hindrance for 27Al+45Sc and other systems with a positive Q value

    International Nuclear Information System (INIS)

    Jiang, C. L.; Rehm, K. E.; Esbensen, H.; Back, B. B.; Janssens, R. V. F.; DiGiovine, B.; Greene, J. P.; Henderson, D. J.; Lee, H. Y.; Pardo, R. C.; Seweryniak, D.; Ugalde, C.; Zhu, S.; Collon, P.; Notani, M.; Tang, X. D.; Deibel, C. M.; Figueira, J. M.; Marley, S. T.; Patel, N.

    2010-01-01

    Fusion evaporation cross sections for the 27 Al+ 45 Sc (Q=9.63 MeV) system are measured down to about 300 nb. Deviations from standard coupled-channels calculations were observed in this system at the lowest energies. The steep fall-off of the fusion cross sections can be reproduced by calculations using a shallow potential model, which was originally developed to explain the hindrance behavior of heavy-ion fusion in medium-mass systems with negative Q values. Comparisons of the hindrance behavior between the present experiment and other systems, for example, 28 Si+ 30 Si (Q=14.3 MeV) and 36 S+ 48 Ca (Q=7.55 MeV) are presented.

  4. The UNAM M. Sc. program in Medical Physics enters its teen years

    Science.gov (United States)

    Brandan, María-Ester

    2010-12-01

    The M.Sc. (Medical Physics) program at the National Autonomous University of Mexico UNAM, created in 1997, has graduated a substantial number of medical physicists who constitute today about 30% of the medical physics clinical workforce in the country. Up to present date (May 2010) more than 60 students have graduated, 60% of them hold clinical jobs, 20% have completed or study a Ph.D., and 15% perform activities related to this specialization. In addition to strengthening the clinical practice of medical physics, the program has served as an incentive for medical physics research in UNAM and other centers. We report the circumstances of the program origin, the evolution of its curriculum, the main achievements, and the next challenges.

  5. Les dimensions politiques d'un projet scientifique: le scénario sismique de Quito

    Directory of Open Access Journals (Sweden)

    1996-01-01

    Full Text Available Le scénario sismique de Quito a été élaboré dans des circonstances particulières qui ont généré un certain nombre de contradictions celles-ci ne sont pas sans conséquence sur le déroulement et les suites du projet. L’analyse de la façon dont a été conçu et organisé ce scénario, la manière dont s’est déroulée la recherche, et sa diffusion, fait apparaître très clairement que le projet s’inscrit en même temps dans trois contradictions : un antagonisme Nord-Sud, une opposition scientifique-politique, et une dissension entre science orthodoxe et science impliquée. Ces éléments constitutifs du scénario sismique de Quito peuvent expliquer le contraste entre, d’une part, sa réussite scientifique objective, matérialisée par la production d’un scénario sismique qui apporte une nouvelle connaissance sur la ville et sa vulnérabilité en cas de tremblement de terre et, d’autre part, la lenteur et la difficulté de la mise en oeuvre d’une politique de prévention des risques basée sur ses résultats. LAS DIMENSIONES POLÍTICAS DE UN PROYECTO CIENTÍFICO: EL MANEJO SÍSMICO DE QUITO. El proyecto de l manejo sísmico de Quito se elaboró en circunstancias particulares que generaron ciertas contradicciones éstas no dejan de repercutir en el desarrollo y las aplicaciones del proyecto. El análisis de la forma en que se concibió y organizó este proyecto, de la manera en que se desarrolló la investigación y se realizó su difusión, revela claramente que el proyecto se inscribe paralelamente dentro de tres contradicciones: un antagonismo Norte-Sur, una oposición ciencia-política y una disensión entre ciencia ortodoxa y ciencia implicada. Estos elementos constitutivos del proyecto sísmico de Quito pueden explicar el contraste entre, por una parte, su éxito científico objetivo, concretado en la elaboración de un proyecto del manejo sísmico que aporta un nuevo conocimiento sobre la ciudad y su vulnerabilidad en

  6. Centro histórico de São José (SC)

    OpenAIRE

    Silva, Tatiana Cristina da

    2006-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programas de Pós-Graduação em Geografia. Este trabalho estuda o caso do Centro Histórico de São José (SC), como espaço simbólico, que confere singularidade e identidade à cidade. Aborda o crescimento da área urbana e seus reflexos no núcleo original, e o momento atual, quando a importância sócio-cultural e econômica deste núcleo é questionada. Povoado de origem açoriana, a cidade sempre...

  7. Human Rights Legalization of Health and Institutional Dialogue : The Experience of Lages -SC , Brazil

    Directory of Open Access Journals (Sweden)

    Felipe Asensi

    2016-05-01

    Full Text Available The judicialization of health tends to be thought through the prism of the lawsuits, but there are lots of consensual strategies that can be developed within the Judiciary Bran- ch. The purpose of this article is to analyze the interaction between the Judiciary Branch, health professionals and the representatives in ensuring the right to health. To this end, a research in partnership with the National Council of Justice was held in 2013 and 2014 in the municipality of Lages-SC, Brazil, which investigated the developed local strategies. The Lages experience was about the Conciliation Center for Medicines and its interaction with the Intermunicipal Consortium and the political and legal actors, which became an institutional dialogue tool. These arrangements allowed a predominantly extrajudicial action and fostered the dialogue between the various local actors. The result was the liti- gation reduction and the expansion of dialogical institutional arrangements.

  8. Sum rates of asynchronous GFDMA and SC-FDMA for 5G uplink

    Directory of Open Access Journals (Sweden)

    Woojin Park

    2015-12-01

    Full Text Available The fifth generation (5G of mobile communication envisions ultralow latency less than 1 ms for radio interface. To this end, frameless asynchronous multiple access may be needed to allow users to transmit instantly without waiting for the next frame start. In this paper, generalized frequency division multiple-access (GFDMA, one of the promising multiple-access candidates for 5G mobile, is compared with the conventional single-carrier FDMA (SC-FDMA in terms of the uplink sum rate when both techniques are adapted for the asynchronous scenario. In particular, a waveform windowing technique is applied to both schemes to mitigate the inter-user interference due to non-zero out-of-band emission.

  9. The ASCI Network for SC '98: Dense Wave Division Multiplexing for Distributed and Distance Computing

    Energy Technology Data Exchange (ETDEWEB)

    Adams, R.L.; Butman, W.; Martinez, L.G.; Pratt, T.J.; Vahle, M.O.

    1999-06-01

    This document highlights the DISCOM's Distance computing and communication team activities at the 1998 Supercomputing conference in Orlando, Florida. This conference is sponsored by the IEEE and ACM. Sandia National Laboratories, Lawrence Livermore National Laboratory, and Los Alamos National Laboratory have participated in this conference for ten years. For the last three years, the three laboratories have a joint booth at the conference under the DOE's ASCI, Accelerated Strategic Computing Initiatives. The DISCOM communication team uses the forum to demonstrate and focus communications and networking developments. At SC '98, DISCOM demonstrated the capabilities of Dense Wave Division Multiplexing. We exhibited an OC48 ATM encryptor. We also coordinated the other networking activities within the booth. This paper documents those accomplishments, discusses the details of their implementation, and describes how these demonstrations support overall strategies in ATM networking.

  10. Final Scientific/Technical Report from Hofstra University on DE-SC0001985

    Energy Technology Data Exchange (ETDEWEB)

    Farmer, E. Christa [Hofstra Univ., Hempstead, NY (United States)

    2016-12-20

    The U.S. Department of Energy award DE-SC0001985 funded the Hofstra University Center for Climate Study (HUCCS) from 29 September 2009 through 1 October 2016. This support enabled several activities over the period of the grant, including 1) the pursuit of several research projects, including sediment coring of coastal marshes, analysis of habitat impact due to climate change, and effects of raindrops of CO2 transfer; 2) support for multiple graduate and undergraduate students, and sponsorship of research projects that involved high school students; 3) fostering mentoring relationships and networking; 4) the design, creation, and installation of an exhibit on climate change at the Cradle of Aviation Museum in Garden City, NY as an effort of public outreach. A total of 11 presentations at conferences, one book, and one peer-reviewed journal article resulted from these activities.

  11. Ants of João da Cunha Island, SC, Brazil: composition and diversity

    Directory of Open Access Journals (Sweden)

    Ricardo Corbetta

    2005-05-01

    Full Text Available The ant species of João da Cunha Island, SC, were collected both manually and by the use of attractive baits of honey and sardine. The samples were taken at 10 sites, each having one bait of each type, totalling 20 samples in each collection. A total of 14 genera, 52 species and 5 subfamilies was sampled in one year of monthly sampling. The richest genera were Pheidole (16 species and Camponotus (9. The biological diversity values were high, and the ant fauna presented a strong seazonality on account of this diversity. The greatest similarity between seasons of the year was observed between spring and summer, followed by autumn and winter.

  12. Redesigning Introductory Science Courses to Teach Sustainability: Introducing the L(SC)2 Paradigm

    Science.gov (United States)

    Myers, J. D.; Campbell-Stone, E.; Massey, G.

    2008-12-01

    Modern societies consume vast quantities of Earth resources at unsustainable levels; at the same time, resource extraction, processing, production, use and disposal have resulted in environmental damage severe enough to threaten the life-support systems of our planet. These threats are produced by multiple, integrative and cumulative environmental stresses, i.e. syndromes, which result from human physical, ecological and social interactions with the environment in specific geographic places. In recent decades, recognition of this growing threat has lead to the concept of sustainability. The science needed to provide the knowledge and know-how for a successful sustainability transition differs markedly from the science that built our modern world. Sustainability science must balanced basic and applied research, promote integrative research focused on specific problems and devise a means of merging fundamental, general scientific principles with understanding of specific places. At the same time, it must use a variety of knowledge areas, i.e. biological systems, Earth systems, technological systems and social systems, to devise solutions to the many complex and difficult problems humankind faces. Clearly, sustainability science is far removed from the discipline-based science taught in most U.S. colleges. Many introductory science courses focus on content, lack context and do not integrate scientific disciplines. To prepare the citizens who will confront future sustainability issues as well as the scientists needed to devise future sustainability strategies, educators and scientists must redesign the typical college science course. A new course paradigm, Literacies and Scientific Content in Social Context (L(SC)2), is ideally suited to teach sustainability science. It offers an alternative approach to liberal science education by redefining and expanding the concept of the interdisciplinary course and merging it with the integrated science course. In addition to

  13. Go Dark Charleston 2017: Preparing the Lowcountry of Charleston, SC for a Unique Celestial Event

    Science.gov (United States)

    Hall, C.; Runyon, C. R.; Royle, M. L.

    2017-12-01

    The August 2017 total solar eclipse will cross the United States, from Oregon to South Carolina, for the first time in almost 100 years. This awe-inspiring event occurs when the moon crosses between the Sun and the Earth, casting a shadow on Earth. Charleston, SC is the final point in this path before the eclipse heads offshore. As such, it provides an opportunity for Charlestonians to witness the grand finale of such an extraordinary celestial event. In collaboration, the Lowcountry Hall of Science and Math (LHSM) and the SC NASA Space Grant Consortium (SCSG) are working with entities across the state to help raise awareness among the general public to the uniqueness of this total solar eclipse. The team is delivering content-rich, hands-on professional development statewide to formal and informal educators, park rangers and city/county government personnel to ensure an understanding behind why we have eclipses as well as safety when viewing eclipses. Our team is working with community organizations, such as sports teams (i.e., Charleston Riverdogs Baseball, Charleston Battery Soccer), museums, aquariums, state and national parks, etc. to bring NASA scientists, engineers and educators together to deliver exciting community demonstrations before, during and after the day of the eclipse. The LHSM, working directly with the Aquarium and Charlestowne Landing State Park, are capturing animal behavior, specifically marine birds and wolves, during the eclipse. In addition, the team is working directly with College of Charleston undergraduates and two local high schools to launch high-altitude balloons to capture video and pictures, as well as, perform science experiments focusing on the eclipse. And finally, the LHSM through SCSG funding, is determining and documenting the extent of knowledge and cultural misconceptions surrounding solar eclipses within the greater Charleston community. In our session, the team will share the outcomes of these varied endeavors.

  14. Electron spin resonance (ESR of magnetic sublattices in Sc-substituted barium hexaferrite

    Directory of Open Access Journals (Sweden)

    Rebeca Díaz-Pardo

    2016-05-01

    Full Text Available The partial substitution of Fe3+ by Sc3+ in barium hexaferrite has shown to be an effective method to tailor anisotropy for many novel microwave applications. Some basic studies have revealed that this substitution leads to unusual interactions among the magnetic sublattices of the ferrite. In order to investigate these interactions, samples with formula BaScxFe12-xO19 (1 ≤x ≤ 2 were prepared by sintering (1300°C, 6h. After structural characterization by x-ray diffraction, their ferromagnetic resonance spectra were measured in the X-band (9.4 GHz, in the 100-500 K temperature range. For x = 2, a single, broad resonance peak was observed at the low temperatures (103 K, exhibiting a progressive splitting into two peaks for increasing T, to finally coalesce again into a single (paramagnetic narrow peak at 473 K. These results are interpreted in terms of a substitution of Fe3+ by Sc3+ ions in the 4fvi and 2b sublattices; the diamagnetic cations disrupt the superexchange interactions and produce a splitting of the 12k sublattice (which interacts directly with the 4fvi sublattice into two sublattices with different canting angles, and different thermal dependence. As a result, the fraction of the 12k sublattices that are nearest neighbours of substituted 4fvi sites can behave as an independent sublattice for some temperature ranges. A similar behavior is observed for all the compositions with varying degrees of amplitude, but it is more evident for x = 2. A deconvolution of peaks has been attempted, in order to shed more light into this behavior.

  15. Electronic structure of the [MNH2]+ (M = Sc-Cu) complexes.

    Science.gov (United States)

    Hendrickx, Marc F A; Clima, Sergiu

    2006-11-23

    B3LYP geometry optimizations for the [MNH2]+ complexes of the first-row transition metal cations (Sc+-Cu+) were performed. Without any exception the ground states of these unsaturated amide complexes were calculated to possess planar geometries. CASPT2 binding energies that were corrected for zero-point energies and including relativistic effects show a qualitative trend across the series that closely resembles the experimental observations. The electronic structures for the complexes of the early and middle transition metal cations (Sc+-Co+) differ from the electronic structures derived for the complexes of the late transition metal cations (Ni+ and Cu+). For the former complexes the relative higher position of the 3d orbitals above the singly occupied 2p(pi) HOMO of the uncoordinated NH2 induces an electron transfer from the 3d shell to 2p(pi). The stabilization of the 3d orbitals from the left to the right along the first-row transition metal series causes these orbitals to become situated below the HOMO of the NH2 ligand for Ni+ and Cu+, preventing a transfer from occurring in the [MNH2]+ complexes of these metal cations. Analysis of the low-lying states of the amide complexes revealed a rather unique characteristic of their electronic structures that was found across the entire series. Rather exceptionally for the whole of chemistry, pi-type interactions were calculated to be stronger than the corresponding sigma-type interactions. The origin of this extraordinary behavior can be ascribed to the low-lying sp2 lone pair orbital of the NH2 ligand with respect to the 3d level.

  16. The Low-Lying Electronic States of Scandium Monocarbide, ScC

    Science.gov (United States)

    Chen, Chiao-Wei; Merer, Anthony; Hsu, Yen-Chu

    2017-06-01

    Extensive wavelength-resolved fluorescence studies have been carried out for the electronic bands of ScC and Sc{}^{13}C lying in the range 14000 - 16000 cm^{-1}. Taken together with detailed rotational analyses of these bands, these studies have clarified the natures of the low-lying electronic states. The ground state is an Ω = 3/2 state, with a vibrational frequency of 648 cm^{-1}, and the first excited electronic state is an Ω = 5/2 state, with a frequency of 712 cm^{-1}, lying 155.54 cm^{-1} higher. These states are assigned as the lowest spin-orbit components of X^2Π_i and a^4Π_i, respectively. The quartet nature of the a state is confirmed by the observation of the ^4Π_{3/2} component, 18.71 cm^{-1} above the ^4Π_{5/2} component. The strongest bands in the region studied are two ^4Δ_{7/2} - ^4Π_{5/2} transitions, where the upper states lie 14355 and 15445 cm^{-1} above X^2Π_{3/2}. Extensive doublet-quartet mixing occurs, which results in some complicated emission patterns. The energy order, a^4Π above X^2Π, is consistent with the ab initio calculations of Kalemos et al., but differs from that found by Simard et al in the isoelectronic YC molecule. A. Kalemos, A. Mavridis and J.F. Harrison, J. Phys. Chem. A155, 755 (2001). B. Simard, P.A. Hackett and W.J. Balfour, Chem. Phys. Lett., 230, 103 (1994).

  17. Psychometric Testing of the Self-Care of Coronary Heart Disease Inventory (SC-CHDI).

    Science.gov (United States)

    Vaughan Dickson, Victoria; Lee, Christopher S; Yehle, Karen S; Mola, Ana; Faulkner, Kenneth M; Riegel, Barbara

    2017-02-01

    Although coronary heart disease (CHD) requires a significant amount of self-care, there are no instruments available to measure self-care in this population. The purpose of this study was to test the psychometric properties of the Self-Care of Coronary Heart Disease Inventory (SC-CHDI). Using the Self-Care of Chronic Illness theory, we developed a 22-item measure of maintenance, management, and confidence appropriate for persons with stable CHD and tested it in a convenience sample of 392 adults (62% male, mean age 61.4 ± 9.6 years). Factorial validity was tested with confirmatory factor analysis. Convergent validity was tested with the Medical Outcomes Study MOS-SAS Specific Adherence Scale and the Decision Making Competency Inventory (DMCI). Cronbach alpha and factor determinacy scores (FDS) were calculated to assess reliability. Two multidimensional self-care scales were confirmed: self-care maintenance included "consultative behaviors" (e.g., taking medicines as prescribed) and "autonomous behaviors" (e.g., exercising 30 minute/day; FDS = .87). The multidimensional self-care management scale included "early recognition and response" (e.g., recognizing symptoms) and "delayed response" (e.g., taking an aspirin; FDS = .76). A unidimensional confidence factor captured confidence in each self-care process (α = .84). All the self-care dimensions were associated with treatment adherence as measured by the MOS-SAS. Only self-care maintenance and confidence were associated with decision-making (DCMI). These findings support the conceptual basis of self-care in patients with CHD as a process of maintenance that includes both consultative and autonomous behaviors, and management with symptom awareness and response. The SC-CHDI confidence scale is promising as a measure of self-efficacy, an important factor influencing self-care. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Human scFv antibodies (Afribumabs) against Africanized bee venom: Advances in melittin recognition.

    Science.gov (United States)

    Pessenda, Gabriela; Silva, Luciano C; Campos, Lucas B; Pacello, Elenice M; Pucca, Manuela B; Martinez, Edson Z; Barbosa, José E

    2016-03-15

    Africanized Apis mellifera bees, also known as killer bees, have an exceptional defensive instinct, characterized by mass attacks that may cause envenomation or death. From the years 2000-2013, 77,066 bee accidents occurred in Brazil. Bee venom comprises several substances, including melittin and phospholipase A2 (PLA2). Due to the lack of antivenom for bee envenomation, this study aimed to produce human monoclonal antibody fragments (single chain fragment variable; scFv), by using phage display technology. These fragments targeted melittin and PLA2, the two major components of bee venom, to minimize their toxic effects in cases of mass envenomation. Two phage antibody selections were performed using purified melittin. As the commercial melittin is contaminated with PLA2, phages specific to PLA2 were also obtained during one of the selections. Specific clones for melittin and PLA2 were selected for the production of soluble scFvs, named here Afribumabs: prefix: afrib- (from Africanized bee); stem/suffix: -umab (fully human antibody). Afribumabs 1 and 2 were tested in in vitro and in vivo assays to assess their ability to inhibit the toxic actions of purified melittin, PLA2, and crude bee venom. Afribumabs reduced hemolysis caused by purified melittin and PLA2 and by crude venom in vitro and reduced edema formation in the paws of mice and prolonged the survival of venom-injected animals in vivo. These results demonstrate that Afribumabs may contribute to the production of the first non-heterologous antivenom treatment against bee envenomation. Such a treatment may overcome some of the difficulties associated with conventional immunotherapy techniques. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Chevaliers de la scène à l’écran

    Directory of Open Access Journals (Sweden)

    Sandra Gorgievski

    2012-08-01

    Full Text Available Le metteur en scène et acteur français Denis Llorca a dirigé le Centre dramatique national de Franche-Comté (1982-1991, avec lequel il a monté d’audacieux spectacles au texte dense, à la durée inhabituelle pour le spectateur moderne : Kings (1978 d’après Shakespeare [dix heures] ; Eux, les possédés (1982 d’après Dostoïevski [huit heures], ou encore Quatre Saisons pour les Chevaliers de la Table Ronde (1989 d’après la légende arthurienne [12 heures]. Avec sa propre compagnie, il a ensuite porté à la scène un projet de sept spectacles s’inspirant des mystères médiévaux, avec des textes empruntés à la Torah, aux Évangiles et au Coran, où le sublime se mêle au grotesque. Dans cet entretien, le réalisateur revient sur ses multiples visions du Moyen Âge dans sa recréation du mythe arthurien au théâtre, mais aussi à l’écran, dans le film qu’il a tiré de la pièce: Les Chevaliers de la Table Ronde (1990 avec Maria Casarès, Alain Cuny et Michel Vitold.

  20. Measuring social capital through multivariate analyses for the IQ-SC.

    Science.gov (United States)

    Campos, Ana Cristina Viana; Borges, Carolina Marques; Vargas, Andréa Maria Duarte; Gomes, Viviane Elisangela; Lucas, Simone Dutra; Ferreira e Ferreira, Efigênia

    2015-01-20

    Social capital can be viewed as a societal process that works toward the common good as well as toward the good of the collective based on trust, reciprocity, and solidarity. Our study aimed to present two multivariate statistical analyses to examine the formation of latent classes of social capital using the IQ-SC and to identify the most important factors in building an indicator of individual social capital. A cross-sectional study was conducted in 2009 among working adolescents supported by a Brazilian NGO. The sample consisted of 363 individuals, and data were collected using the World Bank Questionnaire for measuring social capital. First, the participants were grouped by a segmentation analysis using the Two Step Cluster method based on the Euclidian distance and the centroid criteria as the criteria for aggregate answers. Using specific weights for each item, discriminant analysis was used to validate the cluster analysis in an attempt to maximize the variance among the groups with respect to the variance within the clusters. "Community participation" and "trust in one's neighbors" contributed significantly to the development of the model with two distinct discriminant functions (p < 0.001). The majority of cases (95.0%) and non-cases (93.1%) were correctly classified by discriminant analysis. The two multivariate analyses (segmentation analysis and canonical discriminant analysis), used together, can be considered good choices for measuring social capital. Our results indicate that it is possible to form three social capital groups (low, medium and high) using the IQ-SC.

  1. Doped Sc2C(OH)2 MXene: new type s-pd band inversion topological insulator

    Science.gov (United States)

    Balcı, Erdem; Özden Akkuş, Ünal; Berber, Savas

    2018-04-01

    The electronic structures of Si and Ge substitutionally doped Sc2C(OH)2 MXene monolayers are investigated in density functional theory. The doped systems exhibit band inversion, and are found to be topological invariants in Z 2 theory. The inclusion of spin orbit coupling results in band gap openings. Our results point out that the Si and Ge doped Sc2C(OH)2 MXene monolayers are topological insulators. The band inversion is observed to have a new mechanism that involves s and pd states.

  2. scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.

    Science.gov (United States)

    Clark, Stephen J; Argelaguet, Ricard; Kapourani, Chantriolnt-Andreas; Stubbs, Thomas M; Lee, Heather J; Alda-Catalinas, Celia; Krueger, Felix; Sanguinetti, Guido; Kelsey, Gavin; Marioni, John C; Stegle, Oliver; Reik, Wolf

    2018-02-22

    Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions. Here, we report a single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling. scNMT-seq (single-cell nucleosome, methylation and transcription sequencing) uses a GpC methyltransferase to label open chromatin followed by bisulfite and RNA sequencing. We validate scNMT-seq by applying it to differentiating mouse embryonic stem cells, finding links between all three molecular layers and revealing dynamic coupling between epigenomic layers during differentiation.

  3. Sports Training

    Science.gov (United States)

    1988-01-01

    Practitioners of martial arts have long seen a need for a precise method of measuring the power of a karate kick or a boxer's punch in training and competition. Impax sensor is a piezoelectric film less than one thousandth of an inch thick, yet extremely durable. They give out a voltage impulse when struck, the greater the force of impact, the higher the voltage. The impulse is transmitted to a compact electronics package where voltage is translated into a force-pounds reading shown on a digital display. Impax, manufactured by Impulse Technology, Inc. is used by martial arts instructors, practitioners, U.S. Olympic Committee Training Center, football blocking sleds, and boxers as well as police defensive tactics, providing a means of evaluating the performance of recruits.

  4. Language Training

    CERN Multimedia

    HR Department

    2009-01-01

    PermanenceA "permanence" for language Training has been set up. If anyone has a question or requires information on any aspect of English or French training please come to our office 5 4-016 at the following times. Lucette Fournier French courses Monday 13.30 - 15.30 Tuesday\t10.30 - 12.30 Tessa Osborne English courses Wednesday\t12.00 - 14.00 Thursday\t11.00 - 13.00 New courses Specific English and French courses - Exam preparation/ We are now offering specific courses in English and French leading to a recognised external examination (e.g. Cambridge, DELF and BULATS). If you are interested in following one of these courses and have at least an upper intermediate level of English or French, please enrol through the following link: http://English courses http://French courses Or contact: Tessa Osborne 72957 (English courses) Lucette Fournier 73483 (French courses) Language Training Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  5. Language Training

    CERN Multimedia

    HR Department

    Permanence A "permanence" for language Training has been set up. If anyone has a question or requires information on any aspect of English or French training please come to our office 5 4-016 at the following times. Lucette Fournier - French courses Monday 13.30 - 15.30 Tuesday\t10.30 - 12.30 Tessa Osborne - English courses Wednesday\t12.00 - 14.00 Thursday\t11.00 - 13.00   New courses Specific English and French courses - Exam preparation/ We are now offering specific courses in English and French leading to a recognised external examination (e.g. Cambridge, DELF, DALF). If you are interested in following one of these courses and have at least an upper intermediate level of English or French, please enrol through the following link:  English courses French courses Or contact: Tessa Osborne 72957 (English courses) Lucette Fournier 73483 (French courses) Language Training Nathalie Dumeaux Tel. 78144 nathalie.dumeaux@cern.ch

  6. Running characteristics of the superconducting magnetically levitated train in the case of the superconducting coil quenching; Chodendo jiki fujo ressha no chodendo coil quenching ji no soko tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Ohashi, H. [Kansai University, Osaka (Japan); Osaki, H.; Masada, E. [The University of Tokyo, Tokyo (Japan)

    1998-07-01

    A superconducting (SC) magnetically levitated (Maglev) transportation system has been developed in Japan and various experiments have been done in the new test line at Yamanashi prefecture. Although the superconducting electrodynamic suspension (EDS) system has the advantage of stable levitation without active control, various electromagnetic or mechanical disturbances can cause the change of gap length and the displacement or oscillation of the bogie. In this system, the severest disturbance is SC coil quenching. Therefore it is important to show the running characteristics of the Maglev train and to increase the stability in this case. We developed three dimensional numerical simulation program for the Maglev train. Using this program, running simulation of the train for Yamanashi new test track was undertaken in the case of SC coil quenching. Because of the damping characteristics of the EDS system, influence of the coil quenching is smaller at a higher speed. In the train model, electromagnetic spring strength of the EDS system is larger than mechanical spring of the secondary suspension system connecting a bogie and cabins. Therefore influence of the quenching is only seen in the cabins connected to the quenched bogie. Demagnetization of the SC coil quenching is considered to increase the stability of the train. Although this method is useful to decrease large guidance force, lateral displacement, yaw and roll angle of the bogie, vertical displacement and pitch angle become large. 10 refs., 17 figs., 2 tabs.

  7. Strength and Conditioning and Concurrent Training Practices in Elite Rugby Union.

    Science.gov (United States)

    Jones, Thomas W; Smith, Andrew; Macnaughton, Lindsay S; French, Duncan N

    2016-12-01

    Jones, TW, Smith, A, Macnaughton, LS, and French, DN. Strength and Conditioning and Concurrent Training Practices in Elite Rugby Union. J Strength Cond Res 30(12): 3354-3366, 2016-There is limited published research on strength and conditioning (S&C) practices in elite rugby union (RU). Information regarding testing batteries and programme design would provide valuable information to both applied practitioners and researchers investigating the influence of training interventions or preperformance strategies. The aim of this study was to detail the current practices of S&C coaches and sport scientists working in RU. A questionnaire was developed that comprised 7 sections: personal details, physical testing, strength and power development, concurrent training, flexibility development, unique aspects of the programme, and any further relevant information regarding prescribed training programmes. Forty-three (41 men, 2 women; age: 33.1 ± 5.3 years) of 52 (83%) coaches responded to the questionnaire. The majority of practitioners worked with international level and/or professional RU athletes. All respondents believed strength training benefits RU performance and reported that their athletes regularly performed strength training. The clean and back squat were rated the most important prescribed exercises. Forty-one (95%) respondents reported prescribing plyometric exercises and 38 (88%) indicated that periodization strategies were used. Forty-two (98%) practitioners reported conducting physical testing, with body composition being the most commonly tested phenotype. Thirty-three (77%) practitioners indicated that the potential muted strength development associated with concurrent training was considered when programming and 27 (63%) believed that strength before aerobic training was more favorable for strength development than vice versa. This research represents the only published survey to date of S&C practices in northern and southern hemisphere RU.

  8. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrates unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) 10:30 -...

  9. On the influence of calcium substitution to the optical properties of Cr3+ doped SrSc2O4

    NARCIS (Netherlands)

    Malysa, Beata; Meijerink, A.; Wu, W.; Jüstel, T.

    2017-01-01

    © 2017 Elsevier B.V.Cr3+ doped (Sr,Ca)Sc2O4 samples were synthesized and investigated in view of their potential application as luminescent converters for high power broad band near infrared (NIR) sources. The synthesis of the Cr3+ activated MSc2O4 (M=Ca, Sr) samples was performed by solid state

  10. 76 FR 47441 - Safety Zone; Apache Pier Labor Day Weekend Fireworks Display, Atlantic Ocean, Myrtle Beach, SC

    Science.gov (United States)

    2011-08-05

    ... Display, Atlantic Ocean, Myrtle Beach, SC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY... vicinity of Apache Pier in Myrtle Beach, South Carolina during a Labor Day weekend fireworks display on... fireworks display is scheduled to take place in Myrtle Beach, South Carolina. The fireworks will be launched...

  11. 75 FR 55613 - Dupont Teijin Films Including On-Site Leased Workers From Schenkers Logistics, Inc., Florence, SC...

    Science.gov (United States)

    2010-09-13

    ... Including On-Site Leased Workers From Schenkers Logistics, Inc., Florence, SC; Amended Certification... Teijin Films, including on-site leased workers from Schenkers Logistics, Inc., Florence, South Carolina... leased workers of Schenkers Logistics, Inc., Florence, South Carolina, who became totally or partially...

  12. Piezoelectric non-linearity in PbSc0.5Ta0.5O3 thin films

    NARCIS (Netherlands)

    Chopra, A.; Kim, Y.; Alexe, M.; Hesse, D.

    2014-01-01

    Epitaxial (001)-oriented PbSc0.5Ta0.5O3 (PST) thin films were deposited by pulsed laser deposition. Local piezoelectric investigations performed by piezoelectric force microscopy show a dual slope for the piezoelectric coefficient. A piezoelectric coefficient of 3 pm/V was observed at voltages up to

  13. 77 FR 1483 - Commissioners of Public Works of the City of Spartanburg, SC; Notice of Availability of...

    Science.gov (United States)

    2012-01-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Commissioners of Public Works of the City of Spartanburg, SC; Notice of... Commission in the Public Reference Room or may be viewed on the Commission's Web site at http://www.ferc.gov...

  14. 76 FR 34220 - Commissioners of Public Works of the City of Spartanburg, SC; Notice of Application for Surrender...

    Science.gov (United States)

    2011-06-13

    ... Energy Regulatory Commission Commissioners of Public Works of the City of Spartanburg, SC; Notice of..., 2010 and supplemented on May 19, 2011. d. Applicant: Commissioners of Public Works of the City of... that the following application has been filed with the Commission and is available for public...

  15. Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience

    NARCIS (Netherlands)

    De Sousa, Paul A.; Steeg, Rachel; Wachter, Elisabeth; Bruce, Kevin; King, Jason; Hoeve, Marieke; Khadun, Shalinee; McConnachie, George; Holder, Julie; Kurtz, Andreas; Seltmann, Stefanie; Dewender, Johannes; Reimann, Sascha; Stacey, Glyn; O'Shea, Orla; Chapman, Charlotte; Healy, Lyn; Zimmermann, Heiko; Bolton, Bryan; Rawat, Trisha; Atkin, Isobel; Veiga, Anna; Kuebler, Bernd; Serano, Blanca Miranda; Saric, Tomo; Hescheler, Jürgen; Brüstle, Oliver; Peitz, Michael; Thiele, Cornelia; Geijsen, Niels; Holst, Bjørn; Clausen, Christian; Lako, Majlinda; Armstrong, Lyle; Gupta, Shailesh K.; Kvist, Alexander J.; Hicks, Ryan; Jonebring, Anna; Brolén, Gabriella; Ebneth, Andreas; Cabrera-Socorro, Alfredo; Foerch, Patrik; Geraerts, Martine; Stummann, Tina C.; Harmon, Shawn; George, Carol; Streeter, Ian; Clarke, Laura; Parkinson, Helen; Harrison, Peter W.; Faulconbridge, Adam; Cherubin, Luca; Burdett, Tony; Trigueros, Cesar; Patel, Minal J.; Lucas, Christa; Hardy, Barry; Predan, Rok; Dokler, Joh; Brajnik, Maja; Keminer, Oliver; Pless, Ole; Gribbon, Philip; Claussen, Carsten; Ringwald, Annette; Kreisel, Beate; Courtney, Aidan; Allsopp, Timothy E.

    2017-01-01

    A fast track “Hot Start” process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) lines. Established practice amongst consortium members was

  16. Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience

    NARCIS (Netherlands)

    De Sousa, Paul A; Steeg, Rachel; Wachter, Elisabeth; Bruce, Kevin; King, Jason; Hoeve, Marieke; Khadun, Shalinee; McConnachie, George; Holder, Julie; Kurtz, Andreas; Seltmann, Stefanie; Dewender, Johannes; Reimann, Sascha; Stacey, Glyn; O'Shea, Orla; Chapman, Charlotte; Healy, Lyn; Zimmermann, Heiko; Bolton, Bryan; Rawat, Trisha; Atkin, Isobel; Veiga, Anna; Kuebler, Bernd; Serano, Blanca Miranda; Saric, Tomo; Hescheler, Jürgen; Brüstle, Oliver; Peitz, Michael; Thiele, Cornelia; Geijsen, Niels; Holst, Bjørn; Clausen, Christian; Lako, Majlinda; Armstrong, Lyle; Gupta, Shailesh K; Kvist, Alexander J; Hicks, Ryan; Jonebring, Anna; Brolén, Gabriella; Ebneth, Andreas; Cabrera-Socorro, Alfredo; Foerch, Patrik; Geraerts, Martine; Stummann, Tina C; Harmon, Shawn; George, Carol; Streeter, Ian; Clarke, Laura; Parkinson, Helen; Harrison, Peter W; Faulconbridge, Adam; Cherubin, Luca; Burdett, Tony; Trigueros, Cesar; Patel, Minal J; Lucas, Christa; Hardy, Barry; Predan, Rok; Dokler, Joh; Brajnik, Maja; Keminer, Oliver; Pless, Ole; Gribbon, Philip; Claussen, Carsten; Ringwald, Annette; Kreisel, Beate; Courtney, Aidan; Allsopp, Timothy E

    A fast track "Hot Start" process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) lines. Established practice amongst consortium members was

  17. Investigations of half-Heusler compounds CrScZ (Z = P, As, Sb): a density functional theory study

    Science.gov (United States)

    Ahmad, R.; Mehmood, N.

    2017-10-01

    First principles investigations are performed to study the half-Heusler compounds CrScZ (Z = P, As, Sb). In our calculations the electronic exchange correlation energy is determined by two approaches, generalized gradient approximation (GGA) and generalized gradient approximation with additional Hubbard-U term for indulging on-site Coulomb interaction (GGA+U), independently. Equilibrium lattice constants are found to be in the range of 5.35–6.60 Å. It is revealed by the analysis of elastic properties that two of the compounds, CrScP and CrScAs, are ductile while the third compound, CrScSb, is brittle in nature in the GGA approach, but all the three compounds are predicted to be ductile in the GGA+U approach. The results of both calculations are shown for comparison. Half-metallicity of these compounds is verified, using both methods, by showing that the spin-down states are semiconducting while the spin-up states are conducting. These compounds possess relatively high total magnetic moments of about  ≈4μB . Several optical properties are also calculated that include the refractive index, extinction coefficient, reflectivity, conductivity, and absorption coefficient.

  18. Pt Skin Versus Pt Skeleton Structures of Pt3Sc as Electrocatalysts for Oxygen Reduction

    DEFF Research Database (Denmark)

    Johansson, Tobias Peter; Ulrikkeholm, Elisabeth Therese; Hernandez-Fernandez, Patricia

    2014-01-01

    . The development of new materials for this reaction is essential in order to increase the overall effeciency of the fuel cell. Herein, we study the effect of ultra high vacuum annealing on the structure and activity of polycrystalline Pt3Sc. Upon annealing in ultra high vacuum a Pt overlayer is formed...

  19. Effect of the leukotriene B4 receptor antagonist, SC-41930, on experimental allergic encephalomyelitis (EAE) in the guinea pig.

    Science.gov (United States)

    Fretland, D J; Widomski, D L; Shone, R L; Levin, S; Gaginella, T S

    1991-09-01

    The accepted model for the human demyelinating disease, multiple sclerosis (MS), is experimental allergic encephalomyelitis (EAE). We assessed the ability of SC-41930(7-[3(4-acetyl-3-methoxy-2-propyl-phenoxy)-propoxy]- 3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxyl acid), to modulate the symptoms of acute EAE generated in guinea pigs. Animals were pretreated with SC-41930 (20 mg/kg, i.p.) for two days followed by thrice-weekly maintenance. At day 52, a significant number of the SC-41930-treated animals were alive as compared to EAE alone. Control animals had an increase in body weight while EAE animals lost over 20% (p less than 0.5) of their body weight by day 18. SC-41930-treatment significantly reduced, but did not completely inhibit the cachectic response. The results indirectly implicate LTB4 in the pathogenesis of EAE. Agents that modify this model be useful in the treatment of human MS.

  20. Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC - the Hot Start experience

    Directory of Open Access Journals (Sweden)

    Paul A. De Sousa

    2017-04-01

    eTOC: The report focuses on the EBiSC experience of rapidly establishing an operational capacity to procure, bank and distribute a foundational collection of established hiPSC lines. It validates the feasibility and defines the challenges of harnessing and integrating the capability and productivity of centres across Europe using commonly available resources currently in the field.

  1. Interface interaction and wetting of Sc2O3 exposed to Cu-Al and Cu-Ti melts

    International Nuclear Information System (INIS)

    Barzilai, S.; Nagar, H.; Froumin, N.; Frage, N.; Aizenshtein, M.

    2009-01-01

    Scandia is a thermodynamically stable oxide and could be used as a structural material for a crucible in order to avoid a melt contamination. In the present study wetting experiments of Cu-Al and Cu-Ti melts on Scandia substrate were preformed at 1423 K by a sessile drop method. It was established that Al and Ti additions lead to the improved wetting and that the final contact angle decreases with increasing the additives concentration. For Al containing melts, the contact angle changes gradually with time, and a relatively thick interaction layer, which consists of Al 2 O 3 , Sc 2 O 3 , and metallic channels, was formed at the Sc 2 O 3 /Cu-Al interface. For Ti containing melts, the final contact angle is achieved already during heating, and an extremely thin layer based on a Ti-Sc-O compound was detected by AES at the Sc 2 O 3 /Cu-Ti interface. The results of a thermodynamic analysis, which takes into account the formation free energy of the oxides, involved in the systems, and the thermodynamic properties of the liquid solutions are in a good agreement with the experimental observations. (orig.)

  2. Effect of Sc{sup 3+} on structural and magnetic properties of Mn-Zn nano ferrites

    Energy Technology Data Exchange (ETDEWEB)

    Angadi, Jagadeesha V.; Matteppanavar, Shidaling; Srinatha, N.; Rudraswamy, B., E-mail: brudraswamy@gmail.com, E-mail: jagadeeshbub@gmail.com [Department of Physics, Bangalore University, Bangalore-560056 (India); Melagiriyappa, E. [Research Resource Center, Visvesvaraya Technological University, Belgaum-590014 (India)

    2016-05-23

    In the present investigation, for the first time, we report on the effect of Sc{sup 3+} on the structural and magnetic properties of Mn{sub 0.5}Zn{sub 0.5}Sc{sub y}Fe{sub 2-y}O{sub 4} (y = 0.01, 0.03 and 0.05) nanoferrites synthesized by solution combustion method using the mixture of fuels. As synthesized powders were characterized for the detailed structural analysis by X-ray diffractometer (XRD), Fourier transmission infrared spectroscopy (FTIR) and room temperature magnetic properties by using vibrating sample magnetometer (VSM). The results of XRD and FTIR confirm that the formation of nano crystalline, single-phased Mn-Zn ferrite with cubic spinel structure belongs to Fd-3m space group. The room temperature magnetic studies shows that, the saturation magnetization (M{sub S}), remanence magnetization (M{sub R}) and magnetic moment (η{sub B}), magnetic particle size (D{sub m}) have found to increase with Sc{sup 3+} ion concentration up to x = 0.3 and then decrease. The values of αY-K and the magnetic particle size (D{sub m}) are found to be in the range of 68-75° and 10-19 nm respectively, with Sc{sup 3+} concentration.

  3. Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head.

    Science.gov (United States)

    Chen, Yi-Xuan; Tao, Shi-Cong; Xu, Zheng-Liang; Yin, Wen-Jing; Zhang, Yue-Lei; Yin, Jun-Hui; Gao, You-Shui; Zhang, Chang-Qing

    2017-05-09

    Alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH). We explored the molecular mechanisms underlying alcohol-induced ONFH and investigated the protective effect of the novel Akt activator SC-79 against this disease. We found that ethanol inhibited expression of the osteogenic genes RUNX2 and OCN, downregulated osteogenic differentiation, impaired the recruitment of Akt to the plasma membrane, and suppressed Akt phosphorylation at Ser473, thereby inhibiting the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells. To assess SC-79's ability to counteract the inhibitory effect of ethanol on Akt-Ser73 phosphorylation, we performed micro-computerized tomography and immunofluorescent staining of osteopontin, osteocalcin and collagen type 1 in a rat model of alcohol-induced ONFH. We found that SC-79 injections inhibited alcohol-induced osteonecrosis. These results show that alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells. We propose that SC-79 treatment to rescue Akt activation could be tested in the clinic as a potential therapeutic approach to preventing the development of alcohol-induced ONFH.

  4. Thermoelastic properties of ScB2, TiB2, YB4 and HoB4

    DEFF Research Database (Denmark)

    Waskowska, A.; Gerward, L.; Staun Olsen, J.

    2011-01-01

    (4)GPa). No pressure-induced phase transformations are observed in any of the above borides up to about 20GPa. A continuous temperature-driven orthorhombic distortion is observed for HoB4 below 285K. Values of the thermal expansion coefficient are reported for ScB2 and HoB4 at 293, 200 and 100K...

  5. Effects of trace elements at the Ni/ScYSZ interface in a model solid oxide fuel cell anode

    DEFF Research Database (Denmark)

    Schmidt, Michael Stenbæk; Hansen, Karin Vels; Norrman, Kion

    2008-01-01

    Two ScYSZ electrolytes with different impurity levels were evaluated by electrochemical impedance spectroscopy using a nickel point electrode setup. The nickel electrodes showed lower electrode polarization resistances on the pure electrolyte than on the impure electrolyte. Time-of-flight seconda...

  6. Media Training

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    With the LHC starting up soon, the world's media are again turning their attention to CERN. We're all likely to be called upon to explain what is happening at CERN to media, friends and neighbours. The seminar will be given by BBC television news journalists Liz Pike and Nadia Marchant, and will deal with the kind of questions we're likely to be confronted with through the restart period. The training is open for everybody. Make sure you arrive early enough to get a seat - there are only 200 seats in the Globe. The session will also be webcast: http://webcast.cern.ch/

  7. ACADEMIC TRAINING

    CERN Document Server

    Françoise Benz

    2002-01-01

    6, 7 May LECTURE SERIES from 11.00 to 12.00 hrs - Auditorium, bldg. 500 Decoding the Human Genome, Scientific basis and ethic and social aspects by S.E. Antonarakis and A. Mauron / Univ. of Geneva Decoding the Human genome is a very up-to-date topic, raising several questions besides purely scientific, in view of the two competing teams (public and private), the ethics of using the results, and the fact that the project went apparently faster and easier than expected. The lecture series will address the following chapters: Scientific basis and challenges, Ethical and social aspects of genomics. Academic Training Françoise Benz Tel. 73127

  8. Cognitive training: How can it be adapted for surgical education?

    Science.gov (United States)

    Wallace, Lauren; Raison, Nicholas; Ghumman, Faisal; Moran, Aidan; Dasgupta, Prokar; Ahmed, Kamran

    2017-08-01

    There is a need for new approaches to surgical training in order to cope with the increasing time pressures, ethical constraints, and legal limitations being placed on trainees. One of the most interesting of these new approaches is "cognitive training" or the use of psychological processes to enhance performance of skilled behaviour. Its ability to effectively improve motor skills in sport has raised the question as to whether it could also be used to improve surgical performance. The aim of this review is to provide an overview of the current evidence on the use of cognitive training within surgery, and evaluate the potential role it can play in surgical education. Scientific database searches were conducted to identify studies that investigated the use of cognitive training in surgery. The key studies were selected and grouped according to the type of cognitive training they examined. Available research demonstrated that cognitive training interventions resulted in greater performance benefits when compared to control training. In particular, cognitive training was found to improve surgical motor skills, as well as a number of non-technical outcomes. Unfortunately, key limitations restricting the generalizability of these findings include small sample size and conceptual issues arising from differing definitions of the term 'cognitive training'. When used appropriately, cognitive training can be a highly effective supplementary training tool in the development of technical skills in surgery. Although further studies are needed to refine our understanding, cognitive training should certainly play an important role in future surgical education. Copyright © 2016 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

  9. ALERTES-SC3: an EEWS prototype for south Iberia peninsula.

    Science.gov (United States)

    Pazos, Antonio; Lopez de Mesa, Mireya; Martín Davila, José; Gallego Carrasco, Javier; Rioja del Rio, Carlos; Morgado, Arturo; Hanka, Winfried; Strollo, Angelo; Cibeira, Angel; Cabieces, Roberto; Carranza, Marta

    2016-04-01

    Since several decades Earthquake Early Warning Systems (EEWS) have been developed for different parts of the world based on the hypothesis of the earthquake characteristics can be derived from the analysis of the low energy P-wave prior to the arrival of more energetic S-waves and later phases. Thereby a time ("lead time") is available to evaluate a warning and perform automatic or semi -automatic actions on certain systems and deliver and alert to the authorities involved in emergency. The South Iberia peninsula area, between SW San Vicente Cape to the East of the Alboran sea, is one of the most seismically active zones in the Ibero-Maghrebian region, with predominantly moderate and superficial seismicity, but also big events with associated tsunamis are well documented in the area, like the 1755 Lisbon earthquake. The main goal of the ALERT-ES (2011-2013) and ALERTES-RIM (2014-2016) Spanish projects has been to develop an EEWS for South Iberia region (ALERTES-SC3 EEWS) from a regional and also an on-site approach, and the study of the scaling laws for this area to estimate the moment magnitude (Mw) and predict the expected PGV (peak ground velocity) and Pd (peak displacement) among other parameters. The ALERTES-SC3 EEWS, regional approach, prototype has been developed at the Royal Spanish Navy Observatory (ROA) and is being tested in near real time for South Iberia area. This prototype, based on the SeisComP3 software package, is largely based on algorithms derived from the analysis of the first seconds of the P wave records. Calculation of several parameters are carried out, mainly the characteristic period (τc), Peak displacement and velocity (Pd, Pv) and maximum period (τPmáx), among others, from which correlations with corresponding earthquake magnitude, peak ground velocities , etc. are derived. Decision tables have been developed in order to deliver warnings (Buforn et al, 2012). The algorithms have been implemented by ROA in the seismic data system Seis

  10. English Training

    CERN Multimedia

    2003-01-01

    General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, rol...

  11. English Training

    CERN Multimedia

    2003-01-01

    General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-p...

  12. Language Training

    CERN Multimedia

    2003-01-01

    Formation en anglais Cours d'anglais général et professionnel La prochaine session se déroulera: du 06 octobre 2003 au 13 février 2004 (interruption de 3/4 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web: http://cern.ch/Training Vous pouvez aussi contacter Mme Benz, tél. 73127 ou Mr Liptow, tél. 72957. General and Professional English Courses The next session will take place: from 06 October 2003 to 13 February 2004 (3/4 weeks break at Christmas). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127 or Mr. Liptow: tel. 72957. Writing Professional Documents in Engl...

  13. Language Training

    CERN Multimedia

    2003-01-01

    Formation en anglais Cours d'anglais général et professionnel La prochaine session se déroulera: du 06 octobre 2003 au 13 février 2004 (interruption de 3/4 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web: http://cern.ch/Training Vous pouvez aussi contacter Mme Benz, tél. 73127 ou Mr Liptow, tél. 72957. General and Professional English Courses The next session will take place: from 06 October 2003 to 13 February 2004 (3/4 weeks break at Christmas). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127 or Mr. Liptow: tel. 72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: ...

  14. Language Training

    CERN Multimedia

    2003-01-01

    Formation en anglais Cours d'anglais général et professionnel La prochaine session se déroulera: du 06 octobre 2003 au 13 février 2004 (interruption de 3/4 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web: http://cern.ch/Training Vous pouvez aussi contacter M. Liptow, tél. 72957. General and Professional English Courses The next session will take place: from 06 October 2003 to 13 February 2004 (3/4 weeks break at Christmas). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957. Writing Professional Documents in English This course is designed for people with a good level of...

  15. Student science enrichment training program

    Energy Technology Data Exchange (ETDEWEB)

    Sandhu, S.S.

    1994-08-01

    This is a report on the Student Science Enrichment Training Program, with special emphasis on chemical and computer science fields. The residential summer session was held at the campus of Claflin College, Orangeburg, SC, for six weeks during 1993 summer, to run concomitantly with the college`s summer school. Fifty participants selected for this program, included high school sophomores, juniors and seniors. The students came from rural South Carolina and adjoining states which, presently, have limited science and computer science facilities. The program focused on high ability minority students, with high potential for science engineering and mathematical careers. The major objective was to increase the pool of well qualified college entering minority students who would elect to go into science, engineering and mathematical careers. The Division of Natural Sciences and Mathematics and engineering at Claflin College received major benefits from this program as it helped them to expand the Departments of Chemistry, Engineering, Mathematics and Computer Science as a result of additional enrollment. It also established an expanded pool of well qualified minority science and mathematics graduates, which were recruited by the federal agencies and private corporations, visiting Claflin College Campus. Department of Energy`s relationship with Claflin College increased the public awareness of energy related job opportunities in the public and private sectors.

  16. Selection of scFv phages specific for chloramphenicol acetyl transferase (CAT), as alternatives for antibodies in CAT detection assays.

    Science.gov (United States)

    Van Dorst, Bieke; Mehta, Jaytry; Rouah-Martin, Elsa; Backeljau, Jelke; De Coen, Wim; Eeckhout, Dominique; De Jaeger, Geert; Blust, Ronny; Robbens, Johan

    2012-10-01

    Reporter gene assays are commonly used in applied toxicology to measure the transcription of genes involved in toxic responses. In these reporter gene assays, transgenic cells are used, which contain a promoter-operator region of a gene of interest fused to a reporter gene. The transcription of the gene of interest can be measured by the detection of the reporter protein. Chloramphenicol acetyl transferase (CAT) is frequently used as a reporter protein in mammalian reporter gene assays. Although CAT can be measured by different detection systems, like enzymatic and immune assays, most of these tests are expensive, time-consuming and labor-intensive. The excellent characteristics of phages, like their high affinity and specificity, their fast, cheap and animal-friendly manufacturing process with low batch-to-batch variations and their stability, make them appropriate as alternatives for antibodies in detection assays. Therefore, in this study single-chain variable fragment (scFv) phages were selected with affinity for CAT. Several scFv phages were selected that showed affinity towards CAT in a screening ELISA. Surface plasmon resonance analyses showed that the tested scFv phages have an affinity for CAT with a dissociation constant (K(d)) around 1 µM. The selected scFv phages in this study could be used as capture elements in a highly sensitive sandwich ELISA to detect CAT concentration as low as 0.1 ng ml⁻¹ or 4 pM. This low detection limit demonstrates the potential of the scFv phages as an alternative for capturing antibodies in a highly sensitive detection test to measure CAT concentrations in reporter gene assays. Copyright © 2011 John Wiley & Sons, Ltd.

  17. Therapeutic monoclonal antibodies: scFv patents as a marker of a new class of potential biopharmaceuticals

    Directory of Open Access Journals (Sweden)

    Manuela Berto Pucca

    2011-03-01

    Full Text Available Monoclonal antibodies represent the fastest growing class of biopharmaceutical products and have a host of applications in medical research, diagnosis, therapy, and basic science. The production of recombinant monoclonal antibodies has revolutionized the generation of immunoglobulins, and their use represents a strategic breakthrough, affecting the global pharmaceutical market for therapeutic proteins. In the present work, a review of scFv, and the number of related patents, has been carried out. The results show that several countries have scFv patents, most notably the United States, China and United Kingdom. The target of these scFv antibodies was also assessed and the results demonstrate that most are directed toward cancer therapy.Anticorpos monoclonais representam a classe de maior crescimento em produtos de biofármacos e possuem várias aplicações em pesquisa médica, diagnóstico, terapias e ciência básica. A produção de anticorpos monoclonais recombinantes revolucionou a geração de imunoglobulinas e sua utilização implica em avanço estratégico, afetando o mercado farmacêutico global de proteínas terapêuticas. No presente trabalho, uma revisão sobre scFv e a relação do seu número de patentes foi analisada. Os resultados mostram que vários países apresentam patentes de scFv com destaque para os Estados Unidos, China e Reino Unido. Os alvos desses anticorpos também foram avaliados e as análises revelaram que a maioria é destinado a terapias contra o câncer.

  18. Inheritance, fine-mapping, and candidate gene analyses of resistance to soybean mosaic virus strain SC5 in soybean.

    Science.gov (United States)

    Karthikeyan, Adhimoolam; Li, Kai; Jiang, Hua; Ren, Rui; Li, Cui; Zhi, Haijian; Chen, Shouyi; Gai, Junyi

    2017-08-01

    Soybean mosaic virus (SMV) is one of the most devastating pathogens for soybeans in China. Among the country-wide 22 strains, SC5 dominates in Huang-Huai and Changjiang valleys. For controlling its damage, the resistance gene was searched through Mendelian inheritance study, gene fine-mapping, and candidate gene analysis combined with qRT-PCR (quantitative real-time polymerase chain reaction) analysis. The parents F 1 , F 2 , and RILs (recombinant inbred lines) of the cross Kefeng-1 (Resistance, R) × NN1138-2 (Susceptible, S) were used to examine the inheritance of SC5-resistance. The F 1 was resistant and the F 2 and RILs segregated in a 3R:1S and 1R:1S ratio, respectively, indicating a single dominant gene conferring the Kefeng-1 resistance. Subsequently, the genomic region conferring the resistance was found in "Bin 352-Bin353 with 500 kb" on Chromosome 2 using the phenotyping data of the 427 RILs and a high-density genetic map with 4703 bin markers. In the 500 kb genomic region, 38 putative genes are contained. The association analysis between the SNPs in a putative gene and the resistance phenotype for the 427 RILs prioritized 11 candidate genes using Chi-square criterion. The expression levels of these genes were tested by qRT-PCR. On infection with SC5, 7 out of the 11 genes had differential expression in Kefeng-1 and NN1138-2. Furthermore, integrating SNP-phenotype association analysis with qRT-PCR expression profiling analysis, Glyma02g13495 was found the most possible candidate gene for SC5-resistance. This finding can facilitate the breeding for SC5-resistance through marker-assisted selection and provide a platform to gain a better understanding of SMV-resistance gene system in soybean.

  19. The asymmetric band structure and electrical behavior of the GdScO3/GaN system

    Science.gov (United States)

    Iacopetti, S.; Shekhter, P.; Winter, R.; Tromm, T. C. U.; Schubert, J.; Eizenberg, M.

    2017-05-01

    III-V nitrides are interesting materials for a very wide variety of electronic and optoelectronic devices. In this study, their interaction with GdScO3 (GSO), a ternary rare earth oxide, is investigated for MOS applications. We compare pulsed laser deposited amorphous and crystalline epitaxial GdScO3 in terms of their band alignment with the underlying GaN substrate and the resulting electrical characteristics of the MOS stack. The crystal structure of GdScO3 and GaN is investigated by means of x-ray diffraction, showing that crystalline oxide is growing epitaxially on GaN. X-ray photoelectron spectroscopy analysis shows a staggered band alignment with a GdScO3-GaN valence band offset of 3.6-3.7 eV, which is reflected in a very asymmetric current-voltage behaviour of the MOS capacitors: breakdown at positive bias, significantly earlier for the crystalline oxide (around 5 MV/cm) compared to the amorphous oxide (around 8 MV/cm), and no breakdown up to a field of -14 MV/cm at negative bias. Transmission electron microscopy images show a crystalline, two-atom thick interface layer between GaN and both crystalline and amorphous GdScO3, which is thought to be an electron barrier between GSO and GaN and a possible source of the staggered band alignment. The electrical behaviour can be exploited for asymmetric nano-electronic devices.

  20. Wavelengths, energy levels and hyperfine structure of Mn II and Sc II.

    Science.gov (United States)

    Nave, Gillian; Pickering, Juliet C.; Townley-Smith, Keeley I. M.; Hala, .

    2015-08-01

    For many decades, the Atomic Spectroscopy Groups at the National Institute of Standards and Technology (NIST) and Imperial College London (ICL) have measured atomic data of astronomical interest. Our spectrometers include Fourier transform (FT) spectrometers at NIST and ICL covering the region 1350 Å to 5.5 μm and a 10.7-m grating spectrometer at NIST covering wavelengths from 300 - 5000 Å. Sources for these spectra include high-current continuous and pulsed hollow cathode (HCL) lamps, Penning discharges, and sliding spark discharges. Recent work has focused on the measurement and analysis of wavelengths, energy levels, and hyperfine structure (HFS) constants for iron-group elements. The analysis of FT spectra of Cr I, Mn I, and Mn II is being led by ICL and is described in a companion poster [1]. Current work being led by NIST includes the analysis of HFS in Mn II, analysis of Mn II in the vacuum ultraviolet, and a comprehensive analysis of Sc II.Comprehensive HFS constants for Mn II are needed for the interpretation of stellar spectra and incorrect abundances may be obtained when HFS is omitted. Holt et al. [2] have measured HFS constants for 59 levels of Mn II using laser spectroscopy. We used FT spectra of Mn/Ni and Mn/Cu HCLs covering wavelength ranges from 1350 Å to 5.4 μm to confirm 26 of the A constants of Holt et al. and obtain values for roughly 40 additional levels. We aim to obtain HFS constants for the majority of lines showing significant HFS that are observed in chemically-peculiar stars.Spectra of Sc HCLs have been recorded from 1800 - 6700 Å using a vacuum ultraviolet FT spectrometer at NIST. Additional measurements to cover wavelengths above 6700 Å and below 1800 Å are in progress. The spectra are being analyzed by NIST and Alighar Muslim University, India in order to derive improved wavelengths, energy levels, and hyperfine structure parameters.This work was partially supported by NASA, the STFC and PPARC (UK), the Royal Society of the UK