Axisymmetric magnetohydrodynamic equilibria in local polar coordinates

International Nuclear Information System (INIS)

Clemente, R.A.

1982-01-01

The Grad--Shafranov equation for an ideal magnetohydrodynamic axisymmetric toroidal configuration is solved analytically in a local polar coordinate system using a novel method which produces solutions valid up to the second order in the inverse aspect ratio expansion

Vacuum magnetic field structure of compact torii

International Nuclear Information System (INIS)

Sobehart, J.R.

1990-01-01

A new class of axisymmetric vacuum field solutions of the Grad--Shafranov equation, which is suitable for describing the field external to a compact torus equilibrium, is presented. In particular, solutions that match straight field lines at infinity are studied

Advanced Tokamak Stability Theory

Science.gov (United States)

Zheng, Linjin

2015-03-01

The intention of this book is to introduce advanced tokamak stability theory. We start with the derivation of the Grad-Shafranov equation and the construction of various toroidal flux coordinates. An analytical tokamak equilibrium theory is presented to demonstrate the Shafranov shift and how the toroidal hoop force can be balanced by the application of a vertical magnetic field in tokamaks. In addition to advanced theories, this book also discusses the intuitive physics pictures for various experimentally observed phenomena.

MHD Flows in Compact Astrophysical Objects Accretion, Winds and Jets

CERN Document Server

Beskin, Vasily S

2010-01-01

Accretion flows, winds and jets of compact astrophysical objects and stars are generally described within the framework of hydrodynamical and magnetohydrodynamical (MHD) flows. Analytical analysis of the problem provides profound physical insights, which are essential for interpreting and understanding the results of numerical simulations. Providing such a physical understanding of MHD Flows in Compact Astrophysical Objects is the main goal of this book, which is an updated translation of a successful Russian graduate textbook. The book provides the first detailed introduction into the method of the Grad-Shafranov equation, describing analytically the very broad class of hydrodynamical and MHD flows. It starts with the classical examples of hydrodynamical accretion onto relativistic and nonrelativistic objects. The force-free limit of the Grad-Shafranov equation allows us to analyze in detail the physics of the magnetospheres of radio pulsars and black holes, including the Blandford-Znajek process of energy e...

Helical axis stellarator equilibrium model

International Nuclear Information System (INIS)

Koniges, A.E.; Johnson, J.L.

1985-02-01

An asymptotic model is developed to study MHD equilibria in toroidal systems with a helical magnetic axis. Using a characteristic coordinate system based on the vacuum field lines, the equilibrium problem is reduced to a two-dimensional generalized partial differential equation of the Grad-Shafranov type. A stellarator-expansion free-boundary equilibrium code is modified to solve the helical-axis equations. The expansion model is used to predict the equilibrium properties of Asperators NP-3 and NP-4. Numerically determined flux surfaces, magnetic well, transform, and shear are presented. The equilibria show a toroidal Shafranov shift

Derivation of regularized Grad's moment system from kinetic equations: modes, ghosts and non-Markov fluxes

Science.gov (United States)

Karlin, Ilya

2018-04-01

Derivation of the dynamic correction to Grad's moment system from kinetic equations (regularized Grad's 13 moment system, or R13) is revisited. The R13 distribution function is found as a superposition of eight modes. Three primary modes, known from the previous derivation (Karlin et al. 1998 Phys. Rev. E 57, 1668-1672. (doi:10.1103/PhysRevE.57.1668)), are extended into the nonlinear parameter domain. Three essentially nonlinear modes are identified, and two ghost modes which do not contribute to the R13 fluxes are revealed. The eight-mode structure of the R13 distribution function implies partition of R13 fluxes into two types of contributions: dissipative fluxes (both linear and nonlinear) and nonlinear streamline convective fluxes. Physical interpretation of the latter non-dissipative and non-local in time effect is discussed. A non-perturbative R13-type solution is demonstrated for a simple Lorentz scattering kinetic model. The results of this study clarify the intrinsic structure of the R13 system. This article is part of the theme issue `Hilbert's sixth problem'.

Remapping HELENA to incompressible plasma rotation parallel to the magnetic field

Energy Technology Data Exchange (ETDEWEB)

Poulipoulis, G.; Throumoulopoulos, G. N. [Physics Department, University of Ioannina, Ioannina 451 10 (Greece); Konz, C. [Max-Planck Institut für Plasma Physics, 85748 Garching bei München (Germany)

2016-07-15

Plasma rotation in connection to both zonal and mean (equilibrium) flows can play a role in the transitions to the advanced confinement regimes in tokamaks, as the L-H transition and the formation of internal transport barriers (ITBs). For incompressible rotation, the equilibrium is governed by a generalised Grad-Shafranov (GGS) equation and a decoupled Bernoulli-type equation for the pressure. For parallel flow, the GGS equation can be transformed to one identical in form with the usual Grad-Shafranov equation. In the present study on the basis of the latter equation, we have extended HELENA, an equilibrium fixed boundary solver. The extended code solves the GGS equation for a variety of the two free-surface-function terms involved for arbitrary Alfvén Mach number and density functions. We have constructed diverted-boundary equilibria pertinent to ITER and examined their characteristics, in particular, as concerns the impact of rotation on certain equilibrium quantities. It turns out that the rotation and its shear affect noticeably the pressure and toroidal current density with the impact on the current density being stronger in the parallel direction than in the toroidal one.

On inverse and direct free boundary problems in the theory of plasma equilibrium in a Tokamak

International Nuclear Information System (INIS)

Demidov, A.; Petrova, V.; Silantiev, V.

1996-01-01

Theorems of existence of simply connected 'plasma' domain for the cylindrical case of the Grad-Shafranov equation Δu = F(u) are given. For the inverse problem upper and lower estimates of normal derivative of u on the boundary of the 'plasma' domain are obtained. (author)

Numerical computation of MHD equilibria

International Nuclear Information System (INIS)

Atanasiu, C.V.

1982-10-01

A numerical code for a two-dimensional MHD equilibrium computation has been carried out. The code solves the Grad-Shafranov equation in its integral form, for both formulations: the free-boundary problem and the fixed boundary one. Examples of the application of the code to tokamak design are given. (author)

Structural Stability of Tokamak Equilibrium: Transport Barriers

Energy Technology Data Exchange (ETDEWEB)

Solano, E. R.

2001-07-01

A generalised theory of structural stability of differential equations is introduced and applied to the Grad-Shafranov equation. It is discussed how the formation and loss of transport barrier could be associated with the appearance/disappearance of equilibria. The equilibrium conjecture is presented: transport barriers are associated with locally diamagnetic regions in the plasma, and affected by the paramagnetism of the bootstrap current. (Author) 18 refs.

Computational study of the influence of mirror parameters on FRC (field-reversed configuration) equilibria:

International Nuclear Information System (INIS)

Fuentes, N.O.; Sakanaka, P.H.

1990-01-01

Field-reversed configuration equilibria are studied by solving the Grad-Shafranov equation. A multiple coil system (main coil and end mirrors) is considered to simulate the coil geometry of CNEA device. First results are presented for computed two-dimensional FRC equilibria produced varying the mirror coil current with two different mirror lenghts. (Author)

Exact solutions for helical magnetohydrodynamic equilibria. II. Nonstatic and nonbarotropic solutions

International Nuclear Information System (INIS)

Villata, M.; Ferrari, A.

1994-01-01

In the framework of the analytical study of magnetohydrodynamic (MHD) equilibria with flow and nonuniform density, a general family of well-behaved exact solutions of the generalized Grad--Shafranov equation and of the whole set of time-independent MHD equations completed by the nonbarotropic ideal gas equation of state is obtained, both in helical and axial symmetry. The helical equilibrium solutions are suggested to be relevant to describe the helical morphology of some astrophysical jets

Analytic description of tokamak equilibrium sustained by high fraction bootstrap current

International Nuclear Information System (INIS)

Shi Bingren

2002-01-01

Recently, to save the current drive power and to obtain more favorable confinement merit for tokamak reactor, large faction bootstrap current sustained equilibrium has attracted great interests both theoretically and experimentally. An powerful expanding technique and the tokamak ordering are used to expand the Grad-Shafranov equation to obtain a series of ordinary differential equations which allow for different sets of input parameters. The fully bootstrap current sustained tokamak equilibria are then solved analytically

Equilibrium poloidal field distributions in reversed-field-pinch toroidal discharges

International Nuclear Information System (INIS)

Baker, D.A.; Mann, L.W.; Schoenberg, K.F.

1982-04-01

A comparison between the analytic formulae of Shafranov for equilibrium in axisymmetric toroidal reversed field pinch (RFP) systems and fully toroidal numerical solutions of the Grad-Shafranov equation is presented as a function of poloidal beta, internal plasma inductance, and aspect ratio. The Shafranov formula for the equilibrium poloidal field distribution is accurate to within 5% for aspect ratios greater than 2, poloidal betas less than 50%, and for plasma current channels that exceed one-third of the minor toroidal radius. The analytic description for the center shift of the innermost flux surface that encloses the plasma current (the Shafranov shift) is accurate to within 15% for aspect ratios greater than 2 and poloidal betas below 50%, provided the shift does not exceed one-tenth of the minor conducting boundary radius. The behavior of the magnetic axis shift as a function of plasma parameters is included. The Shafranov formulae provide a convenient method for describing the equilibrium behavior of an RFP discharge. Examples illustrating the application of the analytic formulae to the Los Alamos ZT-40M RFP experiment are given

Equilibrium poloidal-field distributions in reversed-field-pinch toroidal discharges

International Nuclear Information System (INIS)

Baker, D.A.; Mann, L.W.; Schoenberg, K.F.

1983-01-01

A comparison between the approximate analytic formulae of Shafranov for equilibrium in axisymmetric toroidal systems and fully toroidal numerical solutions of the Grad-Shafranov equation for reversed-field-pinch (RFP) configurations is presented as a function of poloidal beta, internal plasma inductance, and aspect ratio. The Shafranov formula for the equilibrium poloidal-field distribution at the conducting shell that surrounds the plasma is accurate to within 5% for aspect ratios greater than 2, poloidal betas less than 50%, and for plasma current channels that exceed one third of the minor toroidal radius. The analytic description for the centre shift of the innermost flux surface that encloses the plasma current (the Shafranov shift) is accurate to within 15% for aspect ratios greater than 2 and poloidal betas below 50%, provided the shift does not exceed one tenth of the minor conducting boundary radius. The Shafranov formulae provide a convenient method for describing the gross equilibrium behaviour of an axisymmetric RFP discharge, as well as an effective tool for designing the poloidal-field systems of RFP experiments. (author)

Nonlinear equilibrium in Tokamaks including convective terms and viscosity

International Nuclear Information System (INIS)

Martin, P.; Castro, E.; Puerta, J.

2003-01-01

MHD equilibrium in tokamaks becomes very complex, when the non-linear convective term and viscosity are included in the momentum equation. In order to simplify the analysis, each new term has been separated in type gradient terms and vorticity depending terms. For the special case in which the vorticity vanishes, an extended Grad-Shafranov type equation can be obtained. However now the magnetic surface is not isobars or current surfaces as in the usual Grad-Shafranov treatment. The non-linear convective terms introduces gradient of Bernoulli type kinetic terms . Montgomery and other authors have shown the importance of the viscosity terms in tokamaks [1,2], here the treatment is carried out for the equilibrium condition, including generalized tokamaks coordinates recently described [3], which simplify the equilibrium analysis. Calculation of the new isobar surfaces is difficult and some computation have been carried out elsewhere for some particular cases [3]. Here, our analysis is extended discussing how the toroidal current density, plasma pressure and toroidal field are modified across the midplane because of the new terms (convective and viscous). New calculations and computations are also presented. (Author)

Linear MHD equilibria

International Nuclear Information System (INIS)

Scheffel, J.

1984-03-01

The linear Grad-Shafranov equation for a toroidal, axisymmetric plasma is solved analytically. Exact solutions are given in terms of confluent hyper-geometric functions. As an alternative, simple and accurate WKBJ solutions are presented. With parabolic pressure profiles, both hollow and peaked toroidal current density profiles are obtained. As an example the equilibrium of a z-pinch with a square-shaped cross section is derived.(author)

Plasma equilibria and stationary flows in axisymmetric systems. Pt. 3

International Nuclear Information System (INIS)

Zelazny, R.; Stankiewicz, R.; Galkowski, A.; Potempski, S.; Pietak, R.

1990-08-01

The problem of the importance of poloidal flows for the behaviour of plasmas in axisymmetric systems has caused a lot of discussion and controversy during the last 15 years. There is no doubt that the mere existence of poloidal flow transforms the elliptic Grad-Shafranov-Schlueter equation into a system of mixed type partial differential equation and an algebraic multivalued Bernoulli equation. This fact leads to the appearance of Bernoulli branches in the solutions. Then, one can come across three branches of elliptic solutions as well as two branches of hyperbolic solutions with the possible appearance of phenomena connected with ''transsonic'' effects. Problems connected with such a mathematical situation have been extensively discussed in the report with the same title, dated May 1988, which we shall call later Part I of our studies on this subject. The present report, considered as Part III, is devoted to the presentation of results of efforts aimed at constructing programmes which allow us to solve the extended Grad-Shafranov-Schlueter equation (EGSS) (with stationary flows) in a more realistic situation relevant to the JET operating conditions. The main problem is to specify for a wider class of profiles the boundary conditions at the magnetic axis for a system of nonlinear ordinary differential equations ODE, resulting from EGSS equation after application of Fourier transformation techniques and of inverse method approach. The present report elaborates a much more general case and describes the computational framework enabling us to derive those boundary conditions. (author)

MHD Equilibrium with Reversed Current Density and Magnetic Islands Revisited: the Vacuum Vector Potential Calculus

Science.gov (United States)

L. Braga, F.

2013-10-01

The solution of Grad-Shafranov equation determines the stationary behavior of fusion plasma inside a tokamak. To solve the equation it is necessary to know the toroidal current density profile. Recent works show that it is possible to determine a magnetohydrodynamic (MHD) equilibrium with reversed current density (RCD) profiles that presents magnetic islands. In this work we show analytical MHD equilibrium with a RCD profile and analyze the structure of the vacuum vector potential associated with these equilibria using the virtual casing principle.

Internal tilting and classical transport for field-reversed configurations based on the Maschke--Hernegger solution

International Nuclear Information System (INIS)

Clemente, R.A.; Grillo, C.E.

1984-01-01

It is shown that elongated field-reversed configurations based on the Maschke--Hernegger solution of the Grad--Shafranov equation are unstable to internal tilting. The particle transport properties across the flux surfaces of such a model are also considered in the limit of large elongation of the separatrix. An estimation of the time of confinement of particles in terms of classical conductivity, which is lower than previous estimates, is given

Equilibrium calculations for helical axis stellarators

International Nuclear Information System (INIS)

Hender, T.C.; Carreras, B.A.

1984-04-01

An average method based on a vacuum flux coordinate system is presented. This average method permits the study of helical axis stellarators with toroidally dominated shifts. An ordering is introduced, and to lowest order the toroidally averaged equilibrium equations are reduced to a Grad-Shafranov equation. Also, to lowest order, a Poisson-type equation is obtained for the toroidally varying corrections to the equilibium. By including these corrections, systems that are toroidally dominated, but with significant helical distortion to the equilibrium, may be studied. Numerical solutions of the average method equations are shown to agree well with three-dimensional calculations

Goya - an MHD equilibrium code for toroidal plasmas

International Nuclear Information System (INIS)

Scheffel, J.

1984-09-01

A description of the GOYA free-boundary equilibrium code is given. The non-linear Grad-Shafranov equation of ideal MHD is solved in a toroidal geometry for plasmas with purely poloidal magnetic fields. The code is based on a field line-tracing procedure, making storage of a large amount of information on a grid unnecessary. Usage of the code is demonstrated by computations of equi/libria for the EXTRAP-T1 device. (Author)

Magnetic configuration dependence of the shafranov shift in the Large Helical Device

Energy Technology Data Exchange (ETDEWEB)

Kobuchi, T; Ida, K; Yamada, H; Yokoyama, M; Watanabe, K Y; Sakakibara, S; Yoshinuma, M [National Institute for Fusion Science, 322-6 Oroshi-Cho, Toki-City, 509-5292 (Japan)

2006-06-15

The dependence of the Shafranov shift on magnetic field configuration, toroidicity and central rotational transform {iota}(0) in neutral beam heated plasma has been experimentally investigated in the Large Helical Device. The toroidicity of the plasma is controlled by the quadrupole field, while the central {iota}(0) is controlled by changing the distance of the current centre of the helical coil to the plasma. It is experimentally confirmed that both the lower toroidicity and the higher {iota}(0) contribute to the reduction of the Shafranov shift as predicted by the three-dimensional equilibrium code, VMEC.

Saturated tearing modes in tokamaks. Renewal proposal, progress report

International Nuclear Information System (INIS)

Bateman, G.

1984-01-01

We have completed a computer code (GTOR) implementing our quasilinear method for determining saturated tearing mode magnetic island widths in axisymmetric toroidal plasmas. With this code we have surveyed the effect of current profile, aspect ratio and plasma elongation on saturated tearing modes. Current peaking within the islands is found to have a particularly large effect. In support of this research, we have developed a direct method for computing Hamada coordinates from harmonics of the inverse Grad-Shafranov equation

MHD equilibrium of toroidal fusion plasma with stationary flows; Rownowaga MHD toroidalnej plazmy termojadrowej z przeplywami

Energy Technology Data Exchange (ETDEWEB)

Galkowski, A. [Institute of Atomic Energy, Otwock-Swierk (Poland)

1994-12-31

Non-linear ideal MHD equilibria in axisymmetric system with flows are examined, both in 1st and 2nd ellipticity regions. Evidence of the bifurcation of solutions is provided and numerical solutions of several problems in a tokamak geometry are given, exhibiting bifurcation phenomena. Relaxation of plasma in the presence of zero-order flows is studied in a realistic toroidal geometry. The field aligned flow allows equilibria with finite pressure gradient but with homogeneous temperature distribution. Numerical calculations have been performed for the 1st and 2nd ellipticity regimes of the extended Grad-Shafranov-Schlueter equation. Numerical technique, alternative to the well-known Grad`s ADM methods has been proposed to deal with slow adiabatic evolution of toroidal plasma with flows. The equilibrium problem with prescribed adiabatic constraints may be solved by simultaneous calculations of flux surface geometry and original profile functions. (author). 178 refs, 37 figs, 5 tabs.

A civil engineering approach to ideal MHD

International Nuclear Information System (INIS)

Jensen, V.O.

1992-01-01

It is well known that a magnetic field can be conceived as a medium where an isotropic compressive stress, B 2 /2μ 0 , is superimposed on a tensile stress, B 2 /μ 0 , parallel to the lines of force. When a stationary ideal MHD plasma is present in the magnetic field, the particle pressure adds to the magnetic stresses to form a combined stress tensor. Calculations of plasma equilibria based on this concept are very similar to calculations in civil engineering of static structures based on compressive, tensile, and shear stresses. Therefore the very simple physical pictures known from civil engineering when used in plasma physics provide simple physical understanding and facilitate the physical interpretation of the results. In an earlier paper the concept was used to derive and discuss the equilibrium equations for θ-, Z-, and screw pinches and the Grad-Shafranov shift in a tokamak plasma with circular cross sections of the flux surfaces. Here the concept is used to discuss the virial theorem and to obtain a simple physical interpretation of this theorem. We also reconsider the Grad-Shafranov shift in a tokamak plasma and show that a situation where all flux surfaces have circular cross sections cannot be an exact solution to the ideal MHD equations. (author) 3 refs., 3 figs

Magnetohydrodynamic stability of tokamak plasmas with poloidal mode coupling

International Nuclear Information System (INIS)

Shigueoka, H.; Sakanaka, P.H.

1987-01-01

The stability behavior with respect to internal modes is examined for a class of tokamak equilibria with non-circular cross sections. The surfaces of the constant poloidal magnetic flux ψ (R,Z) are obtained numerically by solving the Grad-Shafranov's equation with a specified shape for the outmost plasma surface. The equation of motion for ideal MHD stability is written in a ortogonal coordinate system (ψ, χ, φ). Th e stability analysis is performance numerically in a truncated set of coupled m (poloidal wave number) equations. The calculations involve no approximations, and so all parameters of the equilibrium solution can be arbitrarily varied. (author) [pt

Two-fluid equilibria with flow

International Nuclear Information System (INIS)

Steinhauer, L.

1999-01-01

The formalism is developed for flowing two-fluid equilibria. The equilibrium system is governed by a pair of second order partial differential equations for the magnetic stream function and the ion stream function plus a Bernoulli-like equation for the density. There are six arbitrary surface function. There are separate characteristic surfaces for each species, which are the guiding-center surfaces. This system is a generalization of the familiar Grad-Shafranov system for a single-fluid equilibrium without flow, which has only one equation and two arbitrary surface functions. In the case of minimum energy equilibria, the six surface functions take on particular forms. (author)

Investigations on application of multigrid method to MHD equilibrium analysis

International Nuclear Information System (INIS)

Ikuno, Soichiro

2000-01-01

The potentiality of application for Multi-grid method to MHD equilibrium analysis is investigated. The nonlinear eigenvalue problem often appears when the MHD equilibria are determined by solving the Grad-Shafranov equation numerically. After linearization of the equation, the problem is solved by use of the iterative method. Although the Red-Black SOR method or Gauss-Seidel method is often used for the solution of the linearized equation, it takes much CPU time to solve the problem. The Multi-grid method is compared with the SOR method for the Poisson Problem. The results of computations show that the CPU time required for the Multi-grid method is about 1000 times as small as that for the SOR method. (author)

Magnetic flux reconstruction methods for shaped tokamaks

International Nuclear Information System (INIS)

Tsui, Chi-Wa.

1993-12-01

The use of a variational method permits the Grad-Shafranov (GS) equation to be solved by reducing the problem of solving the 2D non-linear partial differential equation to the problem of minimizing a function of several variables. This high speed algorithm approximately solves the GS equation given a parameterization of the plasma boundary and the current profile (p' and FF' functions). The author treats the current profile parameters as unknowns. The goal is to reconstruct the internal magnetic flux surfaces of a tokamak plasma and the toroidal current density profile from the external magnetic measurements. This is a classic problem of inverse equilibrium determination. The current profile parameters can be evaluated by several different matching procedures. Matching of magnetic flux and field at the probe locations using the Biot-Savart law and magnetic Green's function provides a robust method of magnetic reconstruction. The matching of poloidal magnetic field on the plasma surface provides a unique method of identifying the plasma current profile. However, the power of this method is greatly compromised by the experimental errors of the magnetic signals. The Casing Principle provides a very fast way to evaluate the plasma contribution to the magnetic signals. It has the potential of being a fast matching method. The performance of this method is hindered by the accuracy of the poloidal magnetic field computed from the equilibrium solver. A flux reconstruction package has been implemented which integrates a vacuum field solver using a filament model for the plasma, a multi-layer perception neural network as an interface, and the volume integration of plasma current density using Green's functions as a matching method for the current profile parameters. The flux reconstruction package is applied to compare with the ASEQ and EFIT data. The results are promising

Some axisymmetric equilibria for certain ideal and resistive magnetohydrodynamics with incompressible flows

Directory of Open Access Journals (Sweden)

S.M. Moawad

Full Text Available In this paper, the equilibrium properties of some ideal and resistive magnetohydrodynamics (MHD are investigated. The governing equations are taken in the steady state for parallel and non-parallel flow to magnetic filed. The governing equations are reduced to Bernoulli-Grad-Shafranov system. The problem of finding exact equilibria to the governing equations in the presence of incompressible mass flows is studied. Several nonlinear equilibria of the governing equations are obtained with aid of constructed constraints. The obtained results cover several previously configurations and include new considerations about the nonlinearity of magnetic flux stream variables. The possibility of applying the obtained results to magnetic confinement devices are discussed. Keywords: Magnetohydrodynamics, Axisymmetric plasma, Resistivity, Incompressible flows, Exact equilibria, Magnetic confinement devices

On steady poloidal and toroidal flows in tokamak plasmas

International Nuclear Information System (INIS)

McClements, K. G.; Hole, M. J.

2010-01-01

The effects of poloidal and toroidal flows on tokamak plasma equilibria are examined in the magnetohydrodynamic limit. ''Transonic'' poloidal flows of the order of the sound speed multiplied by the ratio of poloidal magnetic field to total field B θ /B can cause the (normally elliptic) Grad-Shafranov (GS) equation to become hyperbolic in part of the solution domain. It is pointed out that the range of poloidal flows for which the GS equation is hyperbolic increases with plasma beta and B θ /B, thereby complicating the problem of determining spherical tokamak plasma equilibria with transonic poloidal flows. It is demonstrated that the calculation of the hyperbolicity criterion can be easily modified when the assumption of isentropic flux surfaces is replaced with the more tokamak-relevant one of isothermal flux surfaces. On the basis of the latter assumption, a simple expression is obtained for the variation of density on a flux surface when poloidal and toroidal flows are simultaneously present. Combined with Thomson scattering measurements of density and temperature, this expression could be used to infer information on poloidal and toroidal flows on the high field side of a tokamak plasma, where direct measurements of flows are not generally possible. It is demonstrated that there are four possible solutions of the Bernoulli relation for the plasma density when the flux surfaces are assumed to be isothermal, corresponding to four distinct poloidal flow regimes. Finally, observations and first principles-based theoretical modeling of poloidal flows in tokamak plasmas are briefly reviewed and it is concluded that there is no clear evidence for the occurrence of supersonic poloidal flows.

Determination of toroidal equilibrium parameters from magnetic probe measurements

International Nuclear Information System (INIS)

Brynolf, J.; Eriksson, H.G.; Persson, H.; Hellblom, G.

1992-12-01

A method has been developed by which the poloidal flux function in the vacuum region between the plasma and the external conductors (and the iron core) can be deduced from external magnetic field measurements. The plasma is in equilibrium and the solution is restricted to plasmas without irregularities. The poloidal field components Bθ and B r are measured at different poloidal positions outside the liner and modelled by truncated Fourier series. The Grad-Shafranov equation in the vacuum region is then solved with these modelled values of Bθ and B r as boundary conditions. (authors)

Magnetohydrodynamic equilibrium with spheroidal plasma-vacuum interface

International Nuclear Information System (INIS)

Kaneko, Shobu; Chiyoda, Katsuji; Hirota, Isao.

1983-01-01

The Grad-Shafranov equations for an oblate and a prolate spheroidal plasmas are solved analytically under the assumptions, Bsub(phi) = 0 and dp/dpsi = constant. Here Bsub(phi) is the toroidal magnetic field, p is the kinetic pressure, and psi is the magnetic flux function. The plasmas in magnetohydrodynamic equilibrium are shown to be toroidal. The equilibrium magnetic-field configurations outside the spheroidal plasmas are considerably different from that of a spherical plasma. A line cusp or two point cusps appear outside the oblate or the prolate spheroidal plasma, respectively. (author)

Helically symmetric equilibria with pressure anisotropy and incompressible plasma flow

Science.gov (United States)

Evangelias, A.; Kuiroukidis, A.; Throumoulopoulos, G. N.

2018-02-01

We derive a generalized Grad-Shafranov equation governing helically symmetric equilibria with pressure anisotropy and incompressible flow of arbitrary direction. Through the most general linearizing ansatz for the various free surface functions involved therein, we construct equilibrium solutions and study their properties. It turns out that pressure anisotropy can act either paramegnetically or diamagnetically, the parallel flow has a paramagnetic effect, while the non-parallel component of the flow associated with the electric field has a diamagnetic one. Also, pressure anisotropy and flow affect noticeably the helical current density.

Revisit to Grad's Closure and Development of Physically Motivated Closure for Phenomenological High-Order Moment Model

International Nuclear Information System (INIS)

Myong, R. S.; Nagdewe, S. P.

2011-01-01

The Grad's closure for the high-order moment equation is revisited and, by extending his theory, a physically motivated closure is developed for the one-dimensional velocity shear gas flow. The closure is based on the physical argument of the relative importance of various terms appearing in the moment equation. Also, the closure is derived such that the resulting theory may be inclusive of the well established linear theory (Navier-Stokes-Fourier) as limiting case near local thermal equilibrium.

Developments in tokamak transport modeling

International Nuclear Information System (INIS)

Houlberg, W.A.; Attenberger; Lao, L.L.

1981-01-01

A variety of numerical methods for solving the time-dependent fluid transport equations for tokamak plasmas is presented. Among the problems discussed are techniques for solving the sometimes very stiff parabolic equations for particle and energy flow, treating convection-dominated energy transport that leads to large cell Reynolds numbers, optimizing the flow of a code to reduce the time spent updating the particle and energy source terms, coupling the one-dimensional (1-D) flux-surface-averaged fluid transport equations to solutions of the 2-D Grad-Shafranov equation for the plasma geometry, handling extremely fast transient problems such as internal MHD disruptions and pellet injection, and processing the output to summarize the physics parameters over the potential operating regime for reactors. Emphasis is placed on computational efficiency in both computer time and storage requirements

Solution of Full Wave Equation for Global Modes in Small Aspect Ratio Tokamaks with Non-Circular Cross-Section

International Nuclear Information System (INIS)

Burma, C.; Cuperman, S.; Komoshvili, K.

1998-01-01

The wave equation for strongly toroidal small aspect ratio (spherical) tokamaks with non-circular cross-section is properly formulated and solved for global waves, in the Alfven frequency range. The current-carrying toroidal plasma is surrounded by a helical sheet-current antenna, which is enclosed within a perfectly conducting wall. The problem is formulated in terms of the vector and scalar potentials (A,Φ), thus avoiding the numerical solution occurring in the case of (E,B) formulation. Adequate boundary conditions are applied at the vacuum - metallic wall interface and the magnetic axis. A recently derived dielectric tensor-operator, able to describe the anisotropic plasma response in spherical tokamaks, is used for this purpose; except for its linear character, no physical or geometrical limitations are imposed on it. The equilibrium profiles (magnetic field, pressure and current) are obtained from a numerical solution of the Grad-Shafranov equation. Specifically, the wave equation is solved by the aid of a numerical code we developed for the present problem, based on the well documented 2(1/2)D finite element solver proposed by E.G. Sewell. With the definitions V i (θ,ρ) = U i (-θ,ρ) (V i U i = A j , Φ; j = ρ,φ,θ), our code solves simultaneously 16 second order partial differential equations (eight equations for each of real and imaginary set of functions V i , U i ). A systematic analysis of the solutions obtained for various values and combinations of wavenumbers and frequencies in the Alfven range is presented

The CHEASE code for toroidal MHD equilibria

International Nuclear Information System (INIS)

Luetjens, H.

1996-03-01

CHEASE solves the Grad-Shafranov equation for the MHD equilibrium of a Tokamak-like plasma with pressure and current profiles specified by analytic forms or sets of data points. Equilibria marginally stable to ballooning modes or with a prescribed fraction of bootstrap current can be computed. The code provides a mapping to magnetic flux coordinates, suitable for MHD stability calculations or global wave propagation studies. The code computes equilibrium quantities for the stability codes ERATO, MARS, PEST, NOVA-W and XTOR and for the global wave propagation codes LION and PENN. The two-dimensional MHD equilibrium (Grad-Shafranov) equation is solved in variational form. The discretization uses bicubic Hermite finite elements with continuous first order derivates for the poloidal flux function Ψ. The nonlinearity of the problem is handled by Picard iteration. The mapping to flux coordinates is carried out with a method which conserves the accuracy of the cubic finite elements. The code uses routines from the CRAY libsci.a program library. However, all these routines are included in the CHEASE package itself. If CHEASE computes equilibrium quantities for MARS with fast Fourier transforms, the NAG library is required. CHEASE is written in standard FORTRAN-77, except for the use of the input facility NAMELIST. CHEASE uses variable names with up to 8 characters, and therefore violates the ANSI standard. CHEASE transfers plot quantities through an external disk file to a plot program named PCHEASE using the UNIRAS or the NCAR plot package. (author) figs., tabs., 34 refs

The CHEASE code for toroidal MHD equilibria

Energy Technology Data Exchange (ETDEWEB)

Luetjens, H. [Ecole Polytechnique, 91 - Palaiseau (France). Centre de Physique Theorique; Bondeson, A. [Chalmers Univ. of Technology, Goeteborg (Sweden). Inst. for Electromagnetic Field Theory and Plasma Physics; Sauter, O. [ITER-San Diego, La Jolla, CA (United States)

1996-03-01

CHEASE solves the Grad-Shafranov equation for the MHD equilibrium of a Tokamak-like plasma with pressure and current profiles specified by analytic forms or sets of data points. Equilibria marginally stable to ballooning modes or with a prescribed fraction of bootstrap current can be computed. The code provides a mapping to magnetic flux coordinates, suitable for MHD stability calculations or global wave propagation studies. The code computes equilibrium quantities for the stability codes ERATO, MARS, PEST, NOVA-W and XTOR and for the global wave propagation codes LION and PENN. The two-dimensional MHD equilibrium (Grad-Shafranov) equation is solved in variational form. The discretization uses bicubic Hermite finite elements with continuous first order derivates for the poloidal flux function {Psi}. The nonlinearity of the problem is handled by Picard iteration. The mapping to flux coordinates is carried out with a method which conserves the accuracy of the cubic finite elements. The code uses routines from the CRAY libsci.a program library. However, all these routines are included in the CHEASE package itself. If CHEASE computes equilibrium quantities for MARS with fast Fourier transforms, the NAG library is required. CHEASE is written in standard FORTRAN-77, except for the use of the input facility NAMELIST. CHEASE uses variable names with up to 8 characters, and therefore violates the ANSI standard. CHEASE transfers plot quantities through an external disk file to a plot program named PCHEASE using the UNIRAS or the NCAR plot package. (author) figs., tabs., 34 refs.

The effect of sheared toroidal rotation on pressure driven magnetic islands in toroidal plasmas

Energy Technology Data Exchange (ETDEWEB)

Hegna, C. C. [Departments of Engineering Physics and Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706 (United States)

2016-05-15

The impact of sheared toroidal rotation on the evolution of pressure driven magnetic islands in tokamak plasmas is investigated using a resistive magnetohydrodynamics model augmented by a neoclassical Ohm's law. Particular attention is paid to the asymptotic matching data as the Mercier indices are altered in the presence of sheared flow. Analysis of the nonlinear island Grad-Shafranov equation shows that sheared flows tend to amplify the stabilizing pressure/curvature contribution to pressure driven islands in toroidal tokamaks relative to the island bootstrap current contribution. As such, sheared toroidal rotation tends to reduce saturated magnetic island widths.

New method for determining central axial orientation of flux rope embedded within current sheet using multipoint measurements

Science.gov (United States)

Li, ZhaoYu; Chen, Tao; Yan, GuangQing

2016-10-01

A new method for determining the central axial orientation of a two-dimensional coherent magnetic flux rope (MFR) via multipoint analysis of the magnetic-field structure is developed. The method is devised under the following geometrical assumptions: (1) on its cross section, the structure is left-right symmetric; (2) the projected structure velocity is vertical to the line of symmetry. The two conditions can be naturally satisfied for cylindrical MFRs and are expected to be satisfied for MFRs that are flattened within current sheets. The model test demonstrates that, for determining the axial orientation of such structures, the new method is more efficient and reliable than traditional techniques such as minimum-variance analysis of the magnetic field, Grad-Shafranov (GS) reconstruction, and the more recent method based on the cylindrically symmetric assumption. A total of five flux transfer events observed by Cluster are studied using the proposed approach, and the application results indicate that the observed structures, regardless of their actual physical properties, fit the assumed geometrical model well. For these events, the inferred axial orientations are all in excellent agreement with those obtained using the multi-GS reconstruction technique.

MHD equilibrium of toroidal fusion plasma with stationary flows

International Nuclear Information System (INIS)

Galkowski, A.

1994-01-01

Non-linear ideal MHD equilibria in axisymmetric system with flows are examined, both in 1st and 2nd ellipticity regions. Evidence of the bifurcation of solutions is provided and numerical solutions of several problems in a tokamak geometry are given, exhibiting bifurcation phenomena. Relaxation of plasma in the presence of zero-order flows is studied in a realistic toroidal geometry. The field aligned flow allows equilibria with finite pressure gradient but with homogeneous temperature distribution. Numerical calculations have been performed for the 1st and 2nd ellipticity regimes of the extended Grad-Shafranov-Schlueter equation. Numerical technique, alternative to the well-known Grad's ADM methods has been proposed to deal with slow adiabatic evolution of toroidal plasma with flows. The equilibrium problem with prescribed adiabatic constraints may be solved by simultaneous calculations of flux surface geometry and original profile functions. (author). 178 refs, 37 figs, 5 tabs

Magnetohydrodynamic equilibrium of axisymmetric systems with toroidal rotation

International Nuclear Information System (INIS)

Mansur, N.L.P.

1986-01-01

A model for studying magnetohydrodynamic equilibrium of axisymetrically confined plasma with toroidal rotation, extended to the Grad. Shafranov equation is presented. The expression used for the scalar pressure is modifiec, and the influence of toroidal magnetic field is included, The equation for general motion of axisymetrically confined plasma, particularizing for rotation movements is described. Two cases are compared: one supposes the entropy as a function of poloidal magnetic flux and other supposes the temperature as a function of flux. The equations for these two cases obtaining a simplified expression by others approximations are established. The proposed model is compared with Shibata model, which uses density as function of flux, and with the ideal spheromak model. A set of cases taking in account experimental data is studied. (M.C.K.) [pt

On the Boltzmann-Grad Limit for Smooth Hard-Sphere Systems

Science.gov (United States)

Tessarotto, Massimo; Cremaschini, Claudio; Mond, Michael; Asci, Claudio; Soranzo, Alessandro; Tironi, Gino

2018-03-01

The problem is posed of the prescription of the so-called Boltzmann-Grad limit operator (L_{BG}) for the N-body system of smooth hard-spheres which undergo unary, binary as well as multiple elastic instantaneous collisions. It is proved, that, despite the non-commutative property of the operator L_{BG}, the Boltzmann equation can nevertheless be uniquely determined. In particular, consistent with the claim of Uffink and Valente (Found Phys 45:404, 2015) that there is "no time-asymmetric ingredient" in its derivation, the Boltzmann equation is shown to be time-reversal symmetric. The proof is couched on the "ab initio" axiomatic approach to the classical statistical mechanics recently developed (Tessarotto et al. in Eur Phys J Plus 128:32, 2013). Implications relevant for the physical interpretation of the Boltzmann H-theorem and the phenomenon of decay to kinetic equilibrium are pointed out.

Jetto a free boundary plasma transport code

International Nuclear Information System (INIS)

Cenacchi, G.; Taroni, A.

1988-01-01

JETTO is a one-and-a-half-dimensional transport code calculating the evolution of plasma parameters in a time dependent axisymmetric MHD equilibrium configuration. A splitting technique gives a consistent solution of coupled equilibrium and transport equations. The plasma boundary is free and defined either by its contact with a limiter (wall) or by a separatrix or by the toroidal magnetic flux. The Grad's approach to the equilibrium problem with adiabatic (or similar) constraints is adopted. This method consists of iterating by alternately solving the Grad-Schluter-Shafranov equation (PDE) and the ODE obtained by averaging the PDE over the magnetic surfaces. The bidimensional equation of the poloidal flux is solved by a finite difference scheme, whereas a Runge-Kutta method is chosen for the averaged equilibrium equation. The 1D transport equations (averaged over the magnetic surfaces) for the electron and ion densities and energies and for the rotational transform are written in terms of a coordinate (ρ) related to the toroidal flux. Impurity transport is also considered, under the hypothesis of coronal equilibrium. The transport equations are solved by an implicit scheme in time and by a finite difference scheme in space. The centering of the source terms and transport coefficients is performed using a Predictor-Corrector scheme. The basic version of the code is described here in detail; input and output parameters are also listed

The Grad Cohort Workshop: Evaluating an Intervention to Retain Women Graduate Students in Computing.

Science.gov (United States)

Stout, Jane G; Tamer, Burçin; Wright, Heather M; Clarke, Lori A; Dwarkadas, Sandhya; Howard, Ayanna M

2016-01-01

Women engaged in computing career tracks are vastly outnumbered by men and often must contend with negative stereotypes about their innate technical aptitude. Research suggests women's marginalized presence in computing may result in women psychologically disengaging, and ultimately dropping out, perpetuating women's underrepresentation in computing. To combat this vicious cycle, the Computing Research Association's Committee on the Status of Women in Computing Research (CRA-W) runs a multi-day mentorship workshop for women graduate students called Grad Cohort, which consists of a speaker series and networking opportunities. We studied the long-term impact of Grad Cohort on women Ph.D. students' (a) dedication to becoming well-known in one's field, and giving back to the community ( professional goals ), (b) the degree to which one feels computing is an important element of "who they are" ( computing identity) , and (c) beliefs that computing skills are innate ( entity beliefs ). Of note, entity beliefs are known to be demoralizing and can lead to disengagement from academic endeavors. We compared a propensity score matched sample of women and men Ph.D. students in computing programs who had never participated in Grad Cohort to a sample of past Grad Cohort participants. Grad Cohort participants reported interest in becoming well-known in their field to a greater degree than women non-participants, and to an equivalent degree as men. Also, Grad Cohort participants reported stronger interest in giving back to the community than their peers. Further, whereas women non-participants identified with computing to a lesser degree than men and held stronger entity beliefs than men, Grad Cohort participants' computing identity and entity beliefs were equivalent to men. Importantly, stronger entity beliefs predicted a weaker computing identity among students, with the exception of Grad Cohort participants. This latter finding suggests Grad Cohort may shield students

A toroidal plasma MHD equilibrium code 'EQUCIR version 1'

International Nuclear Information System (INIS)

Ninomiya, Hiromasa; Shinya, Kichiro; Kameari, Akihisa.

1980-10-01

A new free-boundary toroidal MHD equilibrium code ''EQUCIR version 1'' has been developed. The central problems approached by this code is as follows: 1) The magnetic flux distribution of a plasma at equilibrium is determined in the given external field. 2) A set of circuit equations between the plasma and the external conductors are constructed. These circuit equations and the Grad-Shafranov equation are solved self-consistently and the time evolutions of plasma equilibria and currents in external conductors are determined at the same time. 3) The currents in the external conductors are determined so that the plasma cross-section and plasma parameters are to be maintained with desired ones. It is shown that this code is very useful for study of the tokamak plasma equilibria, for design of the poloidal coil system and for investigation of experimental results. (author)

Effects of toroidicity on resistive tearing modes

International Nuclear Information System (INIS)

Izzo, R.; Monticello, D.A.; Manickam, J.; Strauss, H.R.; Grimm, R.; McGuire, K.

1983-03-01

A reduced set of resistive MHD equations is solved numerically in three dimensions to study the stability of tokamak plasmas. Toroidal effects are included self-consistently to leading and next order in inverse aspect ratio, epsilon. The equations satisfy an energy integral. In addition, the momentum equation yields the Grad-Shafranov equation correct to all orders in epsilon. Low beta plasma are studied using several different q-profiles. In all cases, the linear growth rates are reduced by finite toroidicity. Excellent agreement with resistive PEST is obtianed. In some cases, toroidal effects lead to complete stabilization of the mode. Nonlinear results show smaller saturated island widths for finite aspect ratio compared to the cylindrical limit. If the current channel is wide enough so as to produce steep gradients towards the outside of the plasma, both the finite aspect ratio cases and cylindrical cases disrupt

Equilibrium of field reversed configurations with rotation. IV. Two space dimensions and many ion species

International Nuclear Information System (INIS)

Qerushi, Artan; Rostoker, Norman

2003-01-01

In a previous paper [N. Rostoker and A. Qerushi, Phys. Plasmas 9, 3057 (2002)] a generalized Grad-Shafranov equation for the plasma flux function was derived which provides a complete description of equilibria of field reversed configurations with rotation. In this paper this fundamental equation is solved for two space dimensions and many ion species. The following fusion fuels are considered: D-T, D-He 3 , and p-B 11 . Using periodic boundary conditions the original differential equation is converted to an equivalent integral equation which involves a Green's function. The integral equation is solved by iteration. Approximate solutions are found for all the fusion fuels considered using a two-dimensional equilibrium model for one type of ion [A. Qerushi and N. Rostoker, Phys. Plasmas 9, 5001 (2002)]. They are used as starting trial functions of the iterations. They turn out to be so close to the real solutions that only a few iterations are needed

MHD equilibria in a straight system with a non-planar magnetic axis

International Nuclear Information System (INIS)

Harafuji, Kenji; Tsunematsu, Toshihide; Azumi, Masafumi; Takeda, Tatsuoki

1984-03-01

Numerical investigations of equilibria with free boundary are made in the straight syste m with a three dimensional magnetic axis. Grad-Shafranov equation is solved by both iterative SOR method and direct method on the basis of LU matrix decomposition. From the standpoint of CPU time, SOR method is better than direct method, when number of outer iterations is executed. A part of the ''Self-Stabilization Effect'' due to the increase of plasma pressure is successfully simulated. On the parameter space where the relation between the rotational transform due to the plasma current and that due to the torsion of helical magnetic axis is subtractive, the convergence region is very small. (author)

Averaged description of 3D MHD equilibrium

International Nuclear Information System (INIS)

Medvedev, S.Yu.; Drozdov, V.V.; Ivanov, A.A.; Martynov, A.A.; Pashekhonov, Yu.Yu.; Mikhailov, M.I.

2001-01-01

A general approach by S.A.Galkin et al. in 1991 to 2D description of MHD equilibrium and stability in 3D systems was proposed. The method requires a background 3D equilibrium with nested flux surfaces to generate the metric of a Riemannian space in which the background equilibrium is described by the 2D equation of Grad-Shafranov type. The equation can be solved then varying plasma profiles and shape to get approximate 3D equilibria. In the framework of the method both planar axis conventional stellarators and configurations with spatial magnetic axis can be studied. In the present report the formulation and numerical realization of the equilibrium problem for stellarators with planar axis is reviewed. The input background equilibria with nested flux surfaces are taken from vacuum magnetic field approximately described by analytic scalar potential

Behind the scenes of GS: shared mobility

CERN Multimedia

Corinne Pralavorio

2014-01-01

The GS-IS team responsible for mobility is working on the problematic equation of improving transport with a growing number of people on site.   Congested car parks and sites that are far apart mean that going from one place to another at CERN often requires patience. Transport is major a concern not only for people working at the Organization, but also those in charge of the road infrastructure. The 120-hectare Meyrin site and the distance between the various sites mean that efficient modes of transport are essential. The growing number of people on site and the increasingly congested car parks have made the problem even trickier. Over the past five years, the GS-IS group has launched several initiatives to facilitate mobility on site without proportionately increasing CERN’s fleet of vehicles. Sharing is the only solution! The shuttle service has been reinforced:  since 2010, four regular routes have been set up as well as a service for operators working shifts during t...

GRAD-MAP: A Joint Physics and Astronomy Diversity Initiative at the University of Maryland

Science.gov (United States)

Steele, Amy; Smith, Robyn; Wilkins, Ashlee; Jameson, Katie

2018-01-01

Graduate Resources for Advancing Diversity with Maryland’s Astronomy and Physics (GRAD-MAP), builds connections between UMD and mid-Atlantic HBCUs, Minority-Serving Institutions (MSIs), and community colleges. We use seminars, forums, and workshops to foster a diverse community of undergraduates prepared to succeed in graduate school, inclusion-minded graduate student mentors, and faculty versed in the experiences of students at MSIs and the need for changes in the fields of physics and astronomy. Now in its fifth year, GRAD-MAP remains a graduate-student-powered initiative with a three-pronged approach: 1) Fall Collaborative Seminars, 2) A Winter Workshop, and 3) A Summer Scholars Program. This coherent set of programming allows GRAD-MAP to do more than just increase the numbers of minority students participating in astronomy and physics research (or worse, simply shuffle around students who already are or would be active in research). GRAD-MAP is committed to identifying students who are otherwise underserved or overlooked by the traditional academic pipeline, not only to get them on the path to be successful undergraduate researchers and eventual graduate applicants, but also to make substantial, sustainable efforts toward making the climate of academic physics and astronomy more inclusive to them and all other underrepresented minority students. We will describe the key elements of our program, highlight successes and lessons learned, and describe future directions for program elements. GRAD-MAP can serve as a model for other universities committed to diversity and inclusion.

Time-dependent free boundary equilibrium and resistive diffusion in a tokamak plasma

International Nuclear Information System (INIS)

Selig, G.

2012-12-01

In a Tokamak, in order to create the necessary conditions for nuclear fusion to occur, a plasma is maintained by applying magnetic fields. Under the hypothesis of an axial symmetry of the tokamak, the study of the magnetic configuration at equilibrium is done in two dimensions, and is deduced from the poloidal flux function. This function is solution of a non linear partial differential equation system, known as equilibrium problem. This thesis presents the time dependent free boundary equilibrium problem, where the circuit equations in the tokamak coils and passive conductors are solved together with the Grad-Shafranov equation to produce a dynamic simulation of the plasma. In this framework, the Finite Element equilibrium code CEDRES has been improved in order to solve the aforementioned dynamic problem. Consistency tests and comparisons with the DINA-CH code on an ITER vertical instability case have validated the results. Then, the resistive diffusion of the plasma current density has been simulated using a coupling between CEDRES and the averaged one-dimensional diffusion equation, and it has been successfully compared with the integrated modeling code CRONOS. (author)

The origin of volcanic rock fragments in Upper Pliocene Grad Member of the Mura Formation, North-Eastern Slovenia

Directory of Open Access Journals (Sweden)

Polona Kralj

2006-12-01

Full Text Available Fresh-water, coarse-grained and detritus-dominated Mura Formation in North Eastern Slovenia includes pyroclastic and volcaniclastic deposits originating from Upper Pliocene volcanic activity of basaltic geochemical character. Although localized in occurrence at the hamlet Grad, these pyroclastic and volcaniclastic sediments forma distinctive depositional unit, for which the term “Grad Member” is proposed and introduced in this paper.In the Grad area no lavas or cinder cones are preserved, and the origin of volcaniclastic fragments still uncertain. For this reason, chemical composition of basaltic rock fragments from the Grad Member volcaniclastics has been studied and compared with basaltic rocks from the neighboring locations at Klöch, Kindsberg, Dölling and Neuhaus. The Grad Member pyroclastic and volcaniclastic deposits seem to be fed from the same source which is different from the occurrences in Austria. That supports the idea about the existence of a local volcanic centre in the present Grad area. The old volcanic edificeswerepossiblydestroyed by the late-stage hydrovolcanic eruptions, and pyroclastic and volcaniclastic deposits subjected to constant reworking by fluvial currents in a dynamic sedimentary environment of alluvial fan and braided river systems.

GRAD-MAP: A Joint Physics and Astronomy Diversity Initiative at the University of Maryland

Science.gov (United States)

Wilkins, Ashlee N.; Jameson, Katherine; Taylor, Corbin James; Anderson, Neil; Megson, Peter; Roberg-Clark, Gareth; Sheppard, Kyle; Uher, Tim; Hammer, Donna; Vogel, Stuart N.

2016-01-01

Graduate Resources for Advancing Diversity with Maryland's Astronomy and Physics (GRAD-MAP), builds connections between UMD and mid-Atlantic HBCUs, Minority-Serving Institutions, and community colleges, and uses seminars, forums, and workshops to foster a diverse community of undergraduates prepared to succeed in graduate school, and is now in its third year. GRAD-MAP launched with a three-pronged approach: 1) Collaborative Seminars, 2) A Winter Workshop, and 3) A Spring Symposium. This program allows GRAD-MAP to do more than just increase the numbers of minority students participating in astronomy and physics research (or, worse, simply shuffle around students who already are or would be); it is committed to identifying students who are otherwise underserved or overlooked by the traditional academic pipeline, not only to get them on the path to be successful undergraduate researchers and eventual graduate applicants, but also to make the climate of academic physics and astronomy more inclusive to them and all other underrepresented minority students. Our poster describes the key elements of our program, and highlights successes and lessons learned; GRAD-MAP can serve as a model for other universities committed to diversity and inclusion.

Equilibrium and Stability Properties of Low Aspect Ratio Mirror Systems: from Neutron Source Design to the Parker Spiral

Science.gov (United States)

Peterson, Ethan; Anderson, Jay; Clark, Mike; Egedal, Jan; Endrizzi, Douglass; Flanagan, Ken; Harvey, Robert; Lynn, Jacob; Milhone, Jason; Wallace, John; Waleffe, Roger; Mirnov, Vladimir; Forest, Cary

2017-10-01

Equilibrium reconstructions of rotating magnetospheres in the lab are computed using a user-friendly extended Grad-Shafranov solver written in Python and various magnetic and kinetic measurements. The stability of these equilibria are investigated using the NIMROD code with two goals: understand the onset of the classic ``wobble'' in the heliospheric current sheet and demonstrating proof-of-principle for a laboratory source of high- β turbulence. Using the same extended Grad-Shafranov solver, equilibria for an axisymmetric, non-paraxial magnetic mirror are used as a design foundation for a high-field magnetic mirror neutron source. These equilibria are numerically shown to be stable to the m=1 flute instability, with higher modes likely stabilized by FLR effects; this provides stability to gross MHD modes in an axisymmetric configuration. Numerical results of RF heating and neutral beam injection (NBI) from the GENRAY/CQL3D code suite show neutron fluxes promising for medical radioisotope production as well as materials testing. Synergistic effects between NBI and high-harmonic fast wave heating show large increases in neutron yield for a modest increase in RF power. work funded by DOE, NSF, NASA.

Finite element computation of plasma equilibria

International Nuclear Information System (INIS)

Rivier, M.

1977-01-01

The applicability of the finite element method is investigated for the numerical solution of the nonlinear Grad-Shafranov equation with free boundary for the flux function of a plasma at equilibrium. This method is based on the case of variational principles and finite dimensional subspaces whose elements are piecewise polynomial functions obtained by a Lagrange type interpolation procedure over a triangulation of the domain. Two cases of plasma pressure (exponential and quadratic including a vacuum region) were examined. In both cases the nonuniqueness of the solutions was shown in exhibiting a deeper solution in the case of exponential pressure function, and a non-constant solution for a quadratic pressure function. In order to get this ''other'' solution, two linearization methods were tested with two different constraints. Different cross sections are investigated

Equilibrium of field reversed configurations with rotation. I. One space dimension and one type of ion

International Nuclear Information System (INIS)

Rostoker, Norman; Qerushi, Artan

2002-01-01

Self-consistent solutions of the Vlasov-Maxwell equations are obtained. They involve rigid rotor distributions. This selection is justified on physical grounds. For this selection the Vlasov equation can be replaced by moment equations which terminate without any additional assumptions. For one-dimensional equilibria with one type of ion these equations have exact solutions. A complete equilibrium solution appropriate to a field reversed configuration with rotation can be obtained by solving a generalized Grad-Shafranov equation for the flux function. From this solution all other physical quantities can be determined. A Green's function method is developed to solve this equation, which provides a basis for an iterative solution. This method has the advantage that at every iteration the boundary conditions are satisfied. In this paper cylindrical geometry with one space dimension and one type of ion is considered, where analytic solutions are available. The convergence of the Green's function method is established. For this nonlinear problem there is usually more than one solution for completely specified boundary conditions (bifurcation). The present method selects one solution. It is applicable to equilibria with many ion species and to two dimensions

Til vægs

DEFF Research Database (Denmark)

Egemose, Ellen

abstraktion og mellem rumlighed og flade, og som i varierende grad strider mod at underordne sig motivernes figurer og handling. Med afsæt fra Wolfgang Iser og Wolfgang Kemps receptionsæstetik – og i et indledende forsøg på at kaste et kritisk blik på projektets geografiske empiriafgrænsning – spørger jeg: Er...

Study on possibility of plasma current profile determination using an analytical model of tokamak equilibrium

International Nuclear Information System (INIS)

Moriyama, Shin-ichi; Hiraki, Naoji

1996-01-01

The possibility of determining the current profile of tokamak plasma from the external magnetic measurements alone is investigated using an analytical model of tokamak equilibrium. The model, which is based on an approximate solution of the Grad-Shafranov equation, can set a plasma current profile expressed with four free parameters of the total plasma current, the poloidal beta, the plasma internal inductance and the axial safety factor. The analysis done with this model indicates that, for a D-shaped plasma, the boundary poloidal magnetic field prescribing the external magnetic field distribution is dependent on the axial safety factor in spite of keeping the boundary safety factor and the plasma internal inductance constant. This suggests that the plasma current profile is reversely determined from the external magnetic analysis. The possibility and the limitation of current profile determination are discussed through this analytical result. (author)

Multiple solutions of a free-boundary FRC equilibrium problem in a metal cylinder

International Nuclear Information System (INIS)

Spencer, R.L.; Hewett, D.W.

1981-01-01

A new approach to the computation of FRC equilibria that avoids previously encountered difficulties is presented. For arbitrary pressure profiles it is computationally expensive, but for one special pressure profile the problem is simple enough to require only minutes of Cray time; it is this problem that we have solved. We solve the Grad-Shafranov equation, Δ/sup */psi = r 2 p'(psi), in an infinitely long flux conserving cylinder of radius a with the boundary conditions that psi(a,z) = -psi/sub w/ and that delta psi/delta z = 0 as [z] approaches infinity. The pressure profile is p'(psi) = cH(psi) where c is a constant and where H(x) is the Heaviside function. We have found four solutions to this problem: There is a purely vacuum state, two z-independent plasma solutions, and an r-z-dependent plasma state

Análisis estructural e invarianza de medición del MBI-GS en trabajadores peruanos (Structural Analysis and Measurement Invariance of MBI-GS in Peruvian Workers

Directory of Open Access Journals (Sweden)

Manuel Fernández-Arata

2015-06-01

Full Text Available Resumen La medición del burnout ha evolucionado con la creación de varios instrumentos y modelos. El Maslach Burnout Inventory - General Survey (MBI-GS es uno de estos instrumentos para medir tres constructos definicionales del burnout: (1 agotamiento emocional, (2 eficacia profesional y (3 indiferencia. Fue creado para un amplio rango de ocupaciones, pero pocas veces se ha verificado su estructura latente e invarianza de medición en Latinoamérica. El presente estudio analiza esta estructura latente y la invarianza de medición del MBI-GS en una muestra de 940 trabajadores peruanos de varias ocupaciones. Se aplicó la metodología de ecuaciones estructurales mediante el análisis factorial confirmatorio, así como la invarianza de medición entre varones y mujeres, imponiendo restricciones sucesivamente más estrictas. Los resultados verificaron satisfactoriamente la estructura de tres dimensiones latentes del MBI-GS, y la invarianza de sus parámetros entre hombres y mujeres. Se discute las implicaciones de los resultados. Abstract The measurement of burnout has evolved into the creation of various tools and models. The Maslach Burnout Inventory - General Survey (MBI-GS is one of these instruments used to measure three definitional constructs of burnout: (1 emotional exhaustion, (2 professional efficiency, and (3 indifference. It was created for a wide range of occupations, but its latent structure and invariance of measurement in Latin America has rarely been verified. The present study analyzes the latent structure and the invariance of measurement of MBI-GS in a sample of 940 Peruvian workers in various occupations. The methodology of structural equations was applied through the confirmatory factor analysis, as well as the invariance of measurement between men and women, imposing restrictions successively more strict. The results satisfactorily verified the structure of three-dimensional latent MBI-GS, and the invariance of its

Plasma equilibria and stationary flows in axisymmetric systems. Pt. 1

International Nuclear Information System (INIS)

Zelazny, R.; Stankiewicz, R.; Potempski, S.

1988-05-01

During discharges within a tokamak device such as JET fluctuations are observed in the plasma, of plasma density, temperature, electric potential and of the magnetic field. These fluctuations have complicated structure and are linked with different kinds of instabilities. However, it is not clear which instabilities are most important in determining the behaviour of the plasma. A comprehensive numerical theory which can predict the effect of the instabilities on the transport of plasma in axisymmetric systems has been sought using the static Grad-Shafranov-Schlueter (SGSS) equation as a basis. However, the static equation was over simplified for the situation in JET with additional heating giving rise to large toroidal flows, and an extended equation (EGSS) was developed. The results of the study include the discovery of algebraic branches of solutions to the EGSS equation even for very small poloidal flows, solutions to the inverse problem for the SGSS and EGSS equations using Fourier decomposition, classification of the boundary condition at the magnetic axis, demonstration of a visible effect of the poloidal flow on the separation of the density surface and the magnetic surface an indication of the existence of multiple branches of solutions to the EGSS and SGSS equations and their relation to stability properties. (U.K.)

Behind the scenes of GS: preventing and curing - the GS-SE group

CERN Document Server

CERN, GS-SE

2013-01-01

With over 3,000 CERN personnel and more than 300 visitors on the site, CERN’s infrastructure takes a real hammering every day of the year. Fortunately, the GS-SE Group is on the watch… Here, like everywhere else, nothing stays shiny and new for very long. That’s why it’s important to carry out regular, even daily, maintenance of buildings, equipment, pipes and roads which every single day see thousands of CERN personnel and visitors passing by. The team responsible for this weighty task is part of the GS-SE Group.

Mixed municipal solid waste (MSW) treatment in Waste centre Spodnji Stari Grad, Krško

OpenAIRE

Kortnik, Jože; Leskovar, Jože

2015-01-01

Review paper Received: October 25, 2013 Accepted: November 7, 2013 Mixed municipal solid waste (MSW) treatment in Waste centre Spodnji Stari Grad, Krško Ravnanje z mešanimi komunalnimi odpadki v Zbirnem centru Spodnji Stari Grad, Krško Jože Kortnik1'*, Jože Leskovar2 University of Ljubljana, Faculty of Natural Sciences and Engineering, Department of Mining and Geotechnology, Aškerčeva 12, 1000 Ljubljana, Slovenia 2Kostak, d. d., Leskovška cesta 2a, 8270 Krško, Slovenia Correspo...

Conceptual Design of Alborz Tokamak Poloidal Coils System

Science.gov (United States)

Mardani, M.; Amrollahi, R.

2013-04-01

The Alborz tokamak is a D-shape cross section tokamak that is under construction in Amirkabir University of Technology. One of the most important parts of tokamak design is the design of the poloidal field system. This part includes the numbers, individual position, currents and number of coil turns of the magnetic field coils. Circular cross section tokamaks have Vertical Field system but since the elongation and triangularity of plasma cross section shaping are important in improving the plasma performance and stability, the poloidal field coils are designed to have a shaped plasma configuration. In this paper the design of vertical field system and the magnetohydrodynamic equilibrium of axisymmetric plasma, as given by the Grad-Shafranov equation will be discussed. The poloidal field coils system consists of 12 circular coils located symmetrically about the equator plane, six inner PF coils and six outer PF coils. Six outer poloidal field coils (PF) are located outside of the toroidal field coils (TF), and six inner poloidal field coils are wound on the inner legs and are located outside of a vacuum vessel.

ZORNOC: a 1 1/2-D tokamak data analysis code for studying noncircular high beta plasmas

International Nuclear Information System (INIS)

Zurro, B.; Wieland, R.M.; Murakami, M.; Swain, D.W.

1980-03-01

A new tokamak data analysis code, ZORNOC, was developed to study noncircular, high beta plasmas in the Impurity Study Experiment (ISX-B). These plasmas exhibit significant flux surface shifts and elongation in both ohmically heated and beam-heated discharges. The MHD equilibrium flux surface geometry is determined by solving the Grad-Shafranov equation based on: (1) the shape of the outermost flux surface, deduced from the magnetic loop probes; (2) a pressure profile, deduced by means of Thomson scattering data (electrons), charge exchange data (ions), and a Fokker-Planck model (fast ions); and (3) a safety factor profile, determined from the experimental data using a simple model (Z/sub eff/ = const) that is self-consistently altered while the plasma equilibrium is iterated. For beam-heated discharches the beam deposition profile is determined by means of a Monte Carlo scheme and the slowing down of the fast ions by means of an analytical solution of the Fokker-Planck equation. The code also carries out an electron power balance and calculates various confinement parameters. The code is described and examples of its operation are given

Axisymmetric Plasma Equilibria in General Relativity

Science.gov (United States)

Elsässer, Klaus

Axisymmetric plasma equilibria near a rotating black hole are considered within the multifluid description. An isothermal two-component plasma with electrons and positrons or ions is determined by four structure functions and the boundary conditions. These structure functions are the Bernoulli function and the toroidal canonical momentum per mass for each species; they remain arbitrary if no gain and loss processes are considered, in close analogy to the free flux functions in ideal magnetohydrodynamics. Several simplifying assumptions allow the reduction of the basic equations to one single scalar equation for the stream function χ of positrons or ions, respectively, playing the rôle of the Grad/Shafranov equation in magnetohydrodynamics; in particular, Maxwell's equations can be solved analytically for a quasineutral plasma when both the charge density and the toroidal electric current density are negligible (in contrast to the Tokamak situation). The basic smallness parameter is the ratio of the skin depth of electrons to the scale length of the metric and fluid quantities, and, in the case of an electron-ion plasma, the mass ratio me/mi. The χ-equation can be solved by standard methods, and simple solutions for a Kerr geometry are available; they show characteristic flow patterns, depending on the structure functions and the boundary conditions.

A study on current density distribution reproduction by bounded-eigenfunction expansion for a tokamak plasma

International Nuclear Information System (INIS)

Kurihara, Kenichi

1997-11-01

Plasma current density distribution is one of the most important controlled variables to determine plasma performance of energy confinement and stability in a tokamak. However, its reproduction by using magnetic measurements solely is recognized to yield an ill-posed problem. A method to presume the formulas giving profiles of plasma pressure and current has been adopted to regularize the ill-posedness, and hence it has been reported the current density distribution can be reproduced as a solution of Grad-Shafranov equation within a certain accuracy. In order to investigate its strict reproducibility from magnetic measurements in this inverse problem, a new method of 'bounded-eigenfunction expansion' is introduced, and it was found that the reproducibility directly corresponds to the independence of a series of the special function. The results from various investigations in an aspect of applied mathematics concerning this inverse problem are presented in detail. (author)

Design and analysis of plasma position and shape control in superconducting tokamak JT-60SC

Energy Technology Data Exchange (ETDEWEB)

Matsukawa, M. E-mail: matsukaw@naka.jaeri.go.jp; Ishida, S.; Sakasai, A.; Urata, K.; Senda, I.; Kurita, G.; Tamai, H.; Sakurai, S.; Miura, Y.M.; Masaki, K.; Shimada, K.; Terakado, T

2003-09-01

The analyses of the plasma position and shape control in the superconducting tokamak JT-60SC in JAERI are presented. The vacuum vessel and stabilizing plates located closely to the plasma are modeled in 3 dimension, and we can take into account the large ports in the vacuum vessel. The linear numerical model used in the design for the plasma feedback control system is based on Grad-Shafranov equation, which allows the plasma surface deformation. For a slower control of the plasma shape, the superconducting equilibrium field (EF) coils outside toroidal field coils are used, while for a fast control of the plasma position, in-vessel normal conducting coils (IV coil) are used. It is shown that the available loop voltages of the EF and IV coils are very limited, but there are sufficient accuracy and acceptable response time of plasma position and shape control.

Design and analysis of plasma position and shape control in superconducting tokamak JT-60SC

International Nuclear Information System (INIS)

Matsukawa, M.; Ishida, S.; Sakasai, A.; Urata, K.; Senda, I.; Kurita, G.; Tamai, H.; Sakurai, S.; Miura, Y.M.; Masaki, K.; Shimada, K.; Terakado, T.

2003-01-01

The analyses of the plasma position and shape control in the superconducting tokamak JT-60SC in JAERI are presented. The vacuum vessel and stabilizing plates located closely to the plasma are modeled in 3 dimension, and we can take into account the large ports in the vacuum vessel. The linear numerical model used in the design for the plasma feedback control system is based on Grad-Shafranov equation, which allows the plasma surface deformation. For a slower control of the plasma shape, the superconducting equilibrium field (EF) coils outside toroidal field coils are used, while for a fast control of the plasma position, in-vessel normal conducting coils (IV coil) are used. It is shown that the available loop voltages of the EF and IV coils are very limited, but there are sufficient accuracy and acceptable response time of plasma position and shape control

Anisotropic plasma with flows in tokamak: Steady state and stability

International Nuclear Information System (INIS)

Ilgisonis, V.I.

1996-01-01

An adequate description of equilibrium and stability of anisotropic plasma with macroscopic flows in tokamaks is presented. The Chew-Goldberger-Low (CGL) approximation is consistently used to analyze anisotropic plasma dynamics. The admissible structure of a stationary flow is found to be the same as in the ideal magnetohydrodynamics with isotropic pressure (MHD), which means an allowance for the same relabeling symmetry as in ideal MHD systems with toroidally nested magnetic surfaces. A generalization of the Grad-Shafranov equation for the case of anisotropic plasma with flows confined in the axisymmetric magnetic field is derived. A variational principle was obtained, which allows for a stability analysis of anisotropic pressure plasma with flows, and takes into account the conservation laws resulting from the relabeling symmetry. This principle covers the previous stability criteria for static CGL plasma and for ideal MHD flows in isotropic plasma as well. copyright 1996 American Institute of Physics

Diagnostics of internal inductance in HT-7

International Nuclear Information System (INIS)

Zeng Li; Wan Baonian; Qian Jinping; Fan Hengyu

2001-01-01

Two arrays of Mirnov coils and a pair of concentric loops have been installed to superconducting tokamak HT-7. Software compensation and digital Fourier series expansion are the two techniques that have been applied successfully in measuring diamagnetic flux of concentric loops and internal inductance. The internal inductance of plasma l i , poloidal beta β p , Grad Shafranov parameter Λ, plasma minor radius α p and the center of the outermost magnetic flux surface Δ g are determined

Cardiac Effects of Attenuating Gsα - Dependent Signaling.

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Marcus R Streit

Full Text Available Inhibition of β-adrenergic signalling plays a key role in treatment of heart failure. Gsα is essential for β-adrenergic signal transduction. In order to reduce side-effects of beta-adrenergic inhibition diminishing β-adrenergic signalling in the heart at the level of Gsα is a promising option.We analyzed the influence of Gsα on regulation of myocardial function and development of cardiac hypertrophy, using a transgenic mouse model (C57BL6/J mice overexpressing a dominant negative Gsα-mutant under control of the α-MHC-promotor. Cardiac phenotype was characterized in vivo and in vitro and under acute and chronic β-adrenergic stimulation. At rest, Gsα-DN-mice showed bradycardia (602 ± 13 vs. 660 ± 17 bpm, p<0.05 and decreased dp/dtmax (5037 ± 546- vs. 6835 ± 505 mmHg/s, p = 0.02. No significant differences were found regarding ejection fraction, heart weight and cardiomyocyte size. β-blockade by propranolol revealed no baseline differences of hemodynamic parameters between wildtype and Gsα-DN-mice. Acute adrenergic stimulation resulted in decreased β-adrenergic responsiveness in Gsα-DN-mice. Under chronic adrenergic stimulation, wildtype mice developed myocardial hypertrophy associated with increase of LV/BW-ratio by 23% (4.4 ± 0.2 vs. 3.5 ± 0.1 mg/g, p<0.01 and cardiac myocyte size by 24% (14927 ± 442 px vs. 12013 ± 583 px, p<0.001. In contrast, both parameters were unchanged in Gsα-DN-mice after chronic isoproterenol stimulation.Overexpression of a dominant negative mutant of Gsα leads to decreased β-adrenergic responsiveness and is protective against isoproterenol-induced hypertrophy. Thus, Gsα-DN-mice provide novel insights into β-adrenergic signal transduction and its modulation in myocardial overload and failure.

Rising Tide II: Do Black Students Benefit as Grad Rates Increase?

Science.gov (United States)

Nichols, Andrew Howard; Eberle-Sudré, Kimberlee; Welch, Meredith

2016-01-01

"Rising Tide II: Do Black Students Benefit as Grad Rates Increase?" looks at a decade of graduation rates for African American students at four-year, public institutions that improved student success during the past decade. It shows that while a majority (almost 70 percent) of institutions we examined improved graduation rates for black…

Measurement of magnetic properties of confined compact toroid plasma (spheromak)

International Nuclear Information System (INIS)

Hwang, Fu-Kwun.

1991-01-01

The theoretical aspect of the spheromak is described in this paper. The MS machine hardware will be explored along with the formation scheme and diagnostic systems. The magnetic pickup probes, their calibration procedures and the data analysis methods will be discussed. Observations from the probe measurements and magnetic properties of the MS spheromak are considered. The axisymmetric Grad-Shafranov equilibrium code calculations are presented and compared with the measurements. Magnetic helicity and its correlation with the experimental observations is described

Grad Nation: A Guidebook to Help Communities Tackle the Dropout Crisis

Science.gov (United States)

Balfanz, Robert; Fox, Joanna Hornig; Bridgeland, John M.; McNaught, Mary

2009-01-01

With more than one million students dropping out of high school each year, Grad Nation is specifically designed to offer solutions and tools for every size community and presents a compelling case for all sectors of society to get involved. The guidebook is part of the Alliance's Dropout Prevention Campaign. The guide brings together the nation's…

Magnetic mapping of the TBR-1 tokamak

International Nuclear Information System (INIS)

Matta, Jose Antonio Sevidanes da.

1994-01-01

Axisymmetric hydromagnetic equilibria for an ideal conducting current fluid are described by means of an asymptotic expansion in powers of the inverse aspect ratio (ε α/R 0 ) that satisfies the Grad-Shafranov equation (equilibrium condition). The main profiles for these equilibria were computer. The effect of non-axisymmetric perturbations on the magnetic surfaces if the tokamak TBR-1 is investigated. The used method is able to show how magnetic field from external helical currents split the rational magnetic surface giving rise to the chain of magnetic islands. The Poincare map of the field line perturbed by resonant helical windings has been obtained numerically for the typical TBR-1 parameters. For increasing parameters of perturbation secondary resonances were observed, that transform the bound-state-like contours of a given island into similar structures of secondary magnetic islands. These results were used to determine the spectrum of the perturbation created by resonant helical windings. (author). 87 refs., 30 figs

Magnetohydrodynamic equilibrium and stability of spheromak with spheroidal plasma-vacuum interface

International Nuclear Information System (INIS)

Kaneko, Shobu; Kamitani, Atsushi; Takimoto, Akio.

1985-05-01

The analytic solutions to the Grad-Shafranov equation are obtained for a prolate and an oblate spheroidal plasma by using Hill's vortex model. Effects of a toroidal magnetic field Bsub(phi) on the MHD equilibrium configurations are investigated by using these analytic solutions. When Bsub(phi) is larger than that of the force-free configuration, the spheroidal plasmas in a vacuum magnetic field are shown to be unable in the MHD equilibrium. The several physical quantities on the equilibrium configuration are evaluated. The spheromak plasma is proved to be unstable if dp/d psi not equal 0 and d 2 V/d psi 2 >= 0 on the magnetic axis. Here p is the pressure and V(psi) the volume surrounded by a magnetic surface of psi=const. The equilibrium configurations of the spheroidal plasmas by using Hill's vortex model are shown to satisfy the above conditions, i.e., to be unstable. (author)

Lyapunov stability analysis of magnetohydrodynamic plasma equilibria with axisymmetric toroidal flow

International Nuclear Information System (INIS)

Almaguer, J.A.; Hameiri, E.; Herrera, J.; Holm, D.D.

1988-01-01

Lyapunov stability conditions for ideal magnetohydrodynamic (MHD) plasmas with mass flow in axisymmetric toroidal geometry are determined in the Eulerian representation. Axisymmetric equilibrium solutions of ideal MHD are associated to critical points of a nonlinearly conserved Lyapunov functional consisting of the sum of the total energy and the following flux-weighted quantities: the circulation along field lines, the angular momentum, the toroidal flux, and the mass content within each flux tube. Conditions sufficient for Lyapunov stability of these equilibria against axisymmetric perturbations are found by taking advantage of the Hamiltonian formalism for ideal MHD. In particular [see Eq. (60)], it is sufficient for Lyapunov stability under linearized dynamics that an axisymmetric equilibrium be subsonic in the appropriate rotating frame, lie in the first elliptic regime of the Bernoulli--Grad--Shafranov (BGS) system of equations, and satisfy one additional, more complicated, condition. Effects of boundary conditions, nonlinearity, and three-dimensionality on MHD stability are also discussed

Magnetohydrodynamic equilibrium and stability of spheromak with spheroidal plasma-vacuum interface

International Nuclear Information System (INIS)

Kaneko, Shobu; Kamitani, Atsushi; Takimoto, Akio

1985-01-01

The analytic solutions to the Grad-Shafranov equation are obtained for a prolate and an oblate spheroidal plasma by using Hill's vortex model. Effects of a toroidal magnetic field Bsub(phi) on the MHD equilibrium configurations are investigated by using these analytic solutions. When Bsub(phi) is stronger than that of the force-free configuration, the spheroidal plasmas in a vacuum magnetic field are shown to be unable in the MHD equilibrium. The several physical quantities on the equilibrium configuration are evaluated. The spheromak plasma is proved to be unstable if dp/d psi not equal 0 and d 2 V/d psi 2 >= 0 on the magnetic axis. Here p is the pressure and V(psi) the volume surrounded by a magnetic surface of psi = const. The equilibrium configurations of the spheroidal plasmas by using Hill's vortex model are shown to satisfy the above conditions, i.e., to be unstable. (author)

ICRF [Ion Cyclotron Range of Frequencies] heating and antenna coupling in a high beta tokamak

International Nuclear Information System (INIS)

Elet, R.S.

1988-01-01

Maxwell's Equations are solved in two-dimensions for the electromagnetic fields in a toroidal cavity using the cold plasma fluid dielectric tensor in the Ion Cyclotron Range of Frequencies (ICRF). The Vector Wave Equation is transformed to a set of two, coupled second-order partial differential equations with inhomogeneous forcing functions which model a wave launcher. The resulting equations are finite differenced and solved numerically with a complex banded matrix algorithm on a Cray-2 computer using a code described in this report. This code is used to study power coupling characteristics of a wave launcher for low and high beta tokamaks. The low and high beta equilibrium tokamak magnetic fields applied in this model are determined from analytic solutions to the Grad-Shafranov equation. The code shows good correspondence with the results of low field side ICRF heating experiments performed on the Tokamak of Fontenay-Aux-Roses (TFR). Low field side and high field side antenna coupling properties for ICRF heating in the Columbia High Beta Tokamak (HBT) experiment are calculated with this code. Variations of antenna position in the tokamak, ionic concentration and plasma density, and volume-averaged beta have been analyzed for HBT. It is found that the location of the antenna with respect to the plasma has the dominant role in the design of an ICRF heating experiment in HBT. 10 refs., 52 figs., 13 tabs

Bibliographie des oeuvres du prof. Anton Grad

Directory of Open Access Journals (Sweden)

Anton Grad

2015-10-01

Full Text Available La mort d'Anton Gr'ad a privé Linguistica d'un infatigable collabdrateur et aussi d'un de ses directeurs les plus remarquables. Sa collaboration à la revue commence dès le premier volume en 1955 -avec l' étude sur l'ordre des mots en ancien et moyen français et celle sur l'emploi des verbes vicaires faire et do en français et en anglais et se poursu'it jusqu' au vingtdeuxième votume. Ce dernier volume où il étudie l'étymolodie de l'oronyme slovène Nanos a été déposé sur son bureau de travail quelques jo~rs avant sa mdrt, survenue le 27 mars 1983.

Operational reliability of the Point Lepreau GS standby generators

Energy Technology Data Exchange (ETDEWEB)

Loughead, D. A.; McGregor, A. T. [Safety and Compllance Group, New Brunswick Electric Power Commission, Point Lepreau Generating Station, P.O.Box 10 Lepreau, New Brunswick E0G 2H0 (Canada)

1986-02-15

Performance of the two Point Lepreau GS standby generators during the first three years of licensed station operation is reviewed. It is shown that the mandated reliability/availability requirements have been met. The nature of starting and running failures has been examined and the consequences, in terms of design and procedural changes, discussed. A brief review of standby generator outages is included to permit estimates of standby generator availability and total Class III standby power unavailability. A pair of simple equations is introduced as a means of estimating the probable economic penalty, both cumulative and incremental, associated with the running failure of one standby generator while the other is on a maintenance outage. (authors)

Operational reliability of the Point Lepreau GS standby generators

International Nuclear Information System (INIS)

Loughead, D.A.; McGregor, A.T.

1986-01-01

Performance of the two Point Lepreau GS standby generators during the first three years of licensed station operation is reviewed. It is shown that the mandated reliability/availability requirements have been met. The nature of starting and running failures has been examined and the consequences, in terms of design and procedural changes, discussed. A brief review of standby generator outages is included to permit estimates of standby generator availability and total Class III standby power unavailability. A pair of simple equations is introduced as a means of estimating the probable economic penalty, both cumulative and incremental, associated with the running failure of one standby generator while the other is on a maintenance outage. (authors)

Behind the scenes of GS: preventing and curing - the GS-SE group (VERSION FR)

CERN Multimedia

CERN, GS-SE

2013-01-01

Avec, chaque jour, plus de 3000 Cernois sur le site et plus de 300 visiteurs, le CERN et ses infrastructures en voient des vertes et des pas mûres. Heureusement, le groupe GS-SE veille au grain… Ici comme partout ailleurs, rien ne reste jamais neuf bien longtemps. D’où l’importance d’entretenir régulièrement, pour ne pas dire « quotidiennement », les bâtiments, équipements, canalisations, routes, qui voient passer, jour après jour, des milliers de Cernois et de visiteurs. Au CERN, l’équipe en charge de cette lourde tâche fait partie du groupe GS-SE.

The GRAD high-altitude balloon flight over Antarctica

International Nuclear Information System (INIS)

Eichhorn, G.; Coldwell, R.L.; Dunnam, F.E.; Rester, A.C.; Trombka, J.I.; Starr, R.; Lasche, G.P.

1989-01-01

The Gamma Ray Advanced Detector(GRAD) consists of a n-type germanium detector inside an active bismuth-germanate Compton and charged particle shield with additional active plastic shielding across the aperture. It will be flown on a high altitude balloon at 36 km altitude at a latitude of 78 degree S over Antarctica for observations of gamma radiation emitted by the radioactive decay of 56 Co in the Supernova SN1987A, for assessment of the performance of bismuth-germanate scintillation material in the radiation environment of near space, for gathering information on the gamma-ray background over Antarctica, and for testing fault-tolerant software

Stability of foot-and-mouth disease virus, its genome and proteins at 37 grad C

International Nuclear Information System (INIS)

Razdan, R.; Sen, A.K.; Rao, B.V.; Suryanarayana, V.V.S.

1996-01-01

Infectivity titers of foot-and-mouth disease virus (FMDV) types Asia 1 and 0 were reduced by 4 and 2 log units, respectively, after incubation at 37 grad C for 12 hours. The stability of the FMDV RNA genome at 37 grad C was studied using 32 P-labelled virus. The RNA of FMDV type 0 was found to be more stable than that of type Asia 1. Oligo(dT)-cellulose chromatography showed that 21 % and 31 % of the labelled RNA were bound to the column in the case of types Asia 1 and 0, respectively. Possible correlation between the poly(A) tail length, accessibility of the genome to nucleases and thermo-stability of the infective virus is discussed. A possible correlation between the thermo-stability of the genome and general distribution of a particular virus type seems to exist. A stable genome associated with poor virus immunogenicity may be responsible for the prevalence of FMDV type 0 in the nature. The isoelectric focussing of structural proteins isolated from the virus samples incubated at 37 grad C revealed charge differences in the major immuno-gen between the two FMDV types. A rapid proteolytic degradation of the viral immuno-gen and stability of the genome may be responsible for frequent outbreaks of FMDV, at least, in the endemic countries. (author)

A study of tearing modes via electron cyclotron emission from tokamak plasmas

International Nuclear Information System (INIS)

Ren, C.

1998-07-01

This thesis studies several tearing mode problems from both theoretical and experimental points of view. A major part of this thesis is to demonstrate that Electron Cyclotron Emission (ECE) is an excellent diagnostic for studying an MHD mode structure and its properties in a tokamak plasma. It is shown that an MHD mode can be detected from the electron temperature fluctuations measured by ECE. The amplitude and phase profiles of the fluctuations contain detailed information about the mode structure. The ECE fluctuation phase profile indicates the magnetic island deformation due to the combination of sheared flow and viscosity. A model is presented to relate qualitatively the observed phase gradient to the local magnetic field, flow velocity shear and viscosity in a 2D slab geometry, using an ideal Ohm's law and the plasma momentum equation including flow and viscosity. Numerical solution of the resultant Grad-Shafranov-like equation describing the deformed island shows that the experimentally observed value of the phase gradient can be obtained under realistic parameters for the shear in the flow velocity and viscosity. A new approach to the tearing mode stability boundary and saturation level is also presented

A study of tearing modes via electron cyclotron emission from tokamak plasmas

Energy Technology Data Exchange (ETDEWEB)

Ren, Chuang [Univ. of Wisconsin, Madison, WI (United States)

1998-07-01

This thesis studies several tearing mode problems from both theoretical and experimental points of view. A major part of this thesis is to demonstrate that Electron Cyclotron Emission (ECE) is an excellent diagnostic for studying an MHD mode structure and its properties in a tokamak plasma. It is shown that an MHD mode can be detected from the electron temperature fluctuations measured by ECE. The amplitude and phase profiles of the fluctuations contain detailed information about the mode structure. The ECE fluctuation phase profile indicates the magnetic island deformation due to the combination of sheared flow and viscosity. A model is presented to relate qualitatively the observed phase gradient to the local magnetic field, flow velocity shear and viscosity in a 2D slab geometry, using an ideal Ohm`s law and the plasma momentum equation including flow and viscosity. Numerical solution of the resultant Grad-Shafranov-like equation describing the deformed island shows that the experimentally observed value of the phase gradient can be obtained under realistic parameters for the shear in the flow velocity and viscosity. A new approach to the tearing mode stability boundary and saturation level is also presented.

Affine Fullerene C60 in a GS-Quasigroup

Directory of Open Access Journals (Sweden)

Vladimir Volenec

2014-01-01

Full Text Available It will be shown that the affine fullerene C60, which is defined as an affine image of buckminsterfullerene C60, can be obtained only by means of the golden section. The concept of the affine fullerene C60 will be constructed in a general GS-quasigroup using the statements about the relationships between affine regular pentagons and affine regular hexagons. The geometrical interpretation of all discovered relations in a general GS-quasigroup will be given in the GS-quasigroup C(1/2(1+5.

G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis.

Directory of Open Access Journals (Sweden)

Run Lei

Full Text Available The heterotrimeric G protein subunit Gsα couples receptors to activate adenylyl cyclase and is required for the intracellular cAMP response and protein kinase A (PKA activation. Gsα is ubiquitously expressed in many cell types; however, the role of Gsα in neural crest cells (NCCs remains unclear. Here we report that NCCs-specific Gsα knockout mice die within hours after birth and exhibit dramatic craniofacial malformations, including hypoplastic maxilla and mandible, cleft palate and craniofacial skeleton defects. Histological and anatomical analysis reveal that the cleft palate in Gsα knockout mice is a secondary defect resulting from craniofacial skeleton deficiencies. In Gsα knockout mice, the morphologies of NCCs-derived cranial nerves are normal, but the development of dorsal root and sympathetic ganglia are impaired. Furthermore, loss of Gsα in NCCs does not affect cranial NCCs migration or cell proliferation, but significantly accelerate osteochondrogenic differentiation. Taken together, our study suggests that Gsα is required for neural crest cells-derived craniofacial development.

Equilibrium and stability studies for an iron-core tokamak with a poloidal divertor

International Nuclear Information System (INIS)

Solano, E.R.; Neilson, G.H.; Lao, L.L.

1989-01-01

A study of plasma equilibrium and stability in a tokamak with an unsaturated iron core is presented. A spool model is developed for the iron. Both, a simplified force balance code and a Grad-Shafranov solver are used to study the plasma equilibrium. It is observed that the iron can strongly modify the conditions for equilibrium and stability, and in some cases an infinite cylinder model for the iron core is not adequate. New criteria for plasma position stability in the presence of an iron core are introduced. 17 refs., 4 figs., 3 tabs

Object Tracking withIphone 3Gs

OpenAIRE

Alin, Lars

2010-01-01

In June of 2007 Apple Inc. released the smartphone Iphone. It was a groundbreaking success that set a new standard for what a smartphone should be able to do. Apple has improved the Iphone every year since then and the 3Gs is the newest Iphone model. As the phones have improved, both when looking at hardware and software, the applications have improved as well. The Iphone 3Gs provides the possibility to use the camera as an application background and with that the possibility to analyze the s...

The roles of electric field shear and Shafranov shift in sustaining high confinement in enhanced reversed shear plasmas on the TFTR tokamak

International Nuclear Information System (INIS)

Synakowski, E.J.; Beer, M.A.

1997-02-01

The relaxation of core transport barriers in TFTR Enhanced Reversed Shear plasmas has been studied by varying the radial electric field using different applied torques from neutral beam injection. Transport rates and fluctuations remain low over a wide range of radial electric field shear, but increase when the local E x B shearing rates are driven below a threshold comparable to the fastest linear growth rates of the dominant instabilities. Shafranov-shift-induced stabilization alone is not able to sustain enhanced confinement

Fast waves mode conversion and energy deposition in simulated, pre-heated, neoclassical, tight aspect ratio tokamak plasmas

Energy Technology Data Exchange (ETDEWEB)

Bruma, C.; Komoshvili, K. [Tel Aviv Univ. (Israel). School of Physics and Astronomy; Coll. of Judea and Samaria, Ariel (Israel); Cuperman, S. [Tel Aviv Univ. (Israel). School of Physics and Astronomy

2000-11-01

Some basic aspects of wave-plasma interaction of special interest for tight aspect ratio (spherical) tokamaks (ST's) are investigated numerically; these aspects include fast mode conversion and energy deposition. The study is based on the numerical solution of the full electro-magnetic (e.m.) wave equation which includes a quite general two-fluid, resistive MHD dielectric tensor, with consideration of equilibrium current and neoclassical effects. A generalized expression for the power absorption appropriate for the above scenario, with consideration of all the basic effects also present in the dielectric tensor-operator, was derived and used. The current-carrying ST-plasma has a circular cross-section and toroidicity effects are simulated by a Grad-Shafranov type, radially dependent axial magnetic field and its shear; however, the Shafranov shift is not considered. Actually, the equilibrium parameters and radial profiles (magnetic field, pressure and current) observed in the low field side (LFS) of spherical tokamaks (viz., START at Culham, UK) are used. Fast magnetosonic waves are launched from an external antenna into this simulated spherical tokamak plasma; these waves are converted to Alfven waves at points (layers) satisfying the Alfven resonance condition. Quantitative-results concerning (i) the structure and space dependence of the mode-converted Alfven waves and (ii) the basic features of the deposited power are presented. Their dependence on the equilibrium plasma current, neoclassical resistivity and electron inertia as well as on those of the antenna launched wave (wave numbers, frequency and current intensity) is systematically studied and discussed. (orig.)

Fast waves mode conversion and energy deposition in simulated, pre-heated, neoclassical, tight aspect ratio tokamak plasmas

International Nuclear Information System (INIS)

Bruma, C.; Komoshvili, K.; Cuperman, S.

2000-01-01

Some basic aspects of wave-plasma interaction of special interest for tight aspect ratio (spherical) tokamaks (ST's) are investigated numerically; these aspects include fast mode conversion and energy deposition. The study is based on the numerical solution of the full electro-magnetic (e.m.) wave equation which includes a quite general two-fluid, resistive MHD dielectric tensor, with consideration of equilibrium current and neoclassical effects. A generalized expression for the power absorption appropriate for the above scenario, with consideration of all the basic effects also present in the dielectric tensor-operator, was derived and used. The current-carrying ST-plasma has a circular cross-section and toroidicity effects are simulated by a Grad-Shafranov type, radially dependent axial magnetic field and its shear; however, the Shafranov shift is not considered. Actually, the equilibrium parameters and radial profiles (magnetic field, pressure and current) observed in the low field side (LFS) of spherical tokamaks (viz., START at Culham, UK) are used. Fast magnetosonic waves are launched from an external antenna into this simulated spherical tokamak plasma; these waves are converted to Alfven waves at points (layers) satisfying the Alfven resonance condition. Quantitative-results concerning (i) the structure and space dependence of the mode-converted Alfven waves and (ii) the basic features of the deposited power are presented. Their dependence on the equilibrium plasma current, neoclassical resistivity and electron inertia as well as on those of the antenna launched wave (wave numbers, frequency and current intensity) is systematically studied and discussed. (orig.)

The structure of an earthward propagating magnetic flux rope early in its evolution: comparison of methods

Directory of Open Access Journals (Sweden)

C. Möstl

2009-05-01

Full Text Available We analyze a magnetic signature associated with the leading edge of a bursty bulk flow observed by Cluster at −19 RE downtail on 22 August 2001. A distinct rotation of the magnetic field was seen by all four spacecraft. This event was previously examined by Slavin et al. (2003b using both linear force-free modeling as well as a curlometer technique. Extending this work, we apply here single- and multi-spacecraft Grad-Shafranov (GS reconstruction techniques to the Cluster observations and find good evidence that the structure encountered is indeed a magnetic flux rope and contains helical magnetic field lines. We find that the flux rope has a diameter of approximately 1 RE, an axial field of 26.4 nT, a velocity of ≈650 km/s, a total axial current of 0.16 MA and magnetic fluxes of order 105 Wb. The field line twist is estimated as half a turn per RE. The invariant axis is inclined at 40° to the ecliptic plane and 10° to the GSM equatorial plane. The flux rope has a force-free core and non-force-free boundaries. When we compare and contrast our results with those obtained from minimum variance, single-spacecraft force-free fitting and curlometer techniques, we find in general fair agreement, but also clear differences such as a higher inclination of the axis to the ecliptic. We further conclude that single-spacecraft methods have limitations which should be kept in mind when applied to THEMIS observations, and that non-force-free GS and curlometer techniques are to be preferred in their analysis. Some properties we derived for this earthward– moving structure are similar to those inferred by Lui et al. (2007, using a different approach, for a tailward-moving flux rope observed during the expansion phase of the same substorm.

Center manifolds for a class of degenerate evolution equations and existence of small-amplitude kinetic shocks

Science.gov (United States)

Pogan, Alin; Zumbrun, Kevin

2018-06-01

We construct center manifolds for a class of degenerate evolution equations including the steady Boltzmann equation and related kinetic models, establishing in the process existence and behavior of small-amplitude kinetic shock and boundary layers. Notably, for Boltzmann's equation, we show that elements of the center manifold decay in velocity at near-Maxwellian rate, in accord with the formal Chapman-Enskog picture of near-equilibrium flow as evolution along the manifold of Maxwellian states, or Grad moment approximation via Hermite polynomials in velocity. Our analysis is from a classical dynamical systems point of view, with a number of interesting modifications to accommodate ill-posedness of the underlying evolution equation.

Analyses of plasma parameter profiles in JT-60U

Energy Technology Data Exchange (ETDEWEB)

Shirai, Hiroshi; Shimizu, Katsuhiro; Hayashi, Nobuhiko [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; Itakura, Hirofumi; Takase, Keizou [CSK Co. Ltd., Tokyo (Japan)

2001-01-01

The methods how diagnostics data are treated as the surface quantity of magnetic surface and processed to the profile data in the JT-60U plasmas are summarized. The MHD equilibrium obtained by solving Grad-Shafranov equation on the MHD equilibrium calculation and registration software FBEQU are saved shot by shot as a database. Various experimental plasma data measured at various geometrical positions on JT-60 are mapped onto the MHD equilibrium and treated as functions of the volume averaged minor radius {rho} on the experimental data time slice monitoring software SLICE. Experimental data are integrated and edited on SLICE. The experimental data measured as the line integral values are transformed by Able inversion. The mapped data are fitted to a functional form and saved to the profile database MAP-DB. SLICE can also read data from MAP-DB and redisplay and transform them. In addition, SLICE can generate the profile data TOKRD as run data for orbit following Monte-Carlo (OFMC) code, analyzer for current drive consistent with MHD equilibrium (ACCOME) code and tokamak predictive and interpretive code system (TOPICS). (author)

Modification of the magnetic field structure in the vicinity of the x-points by the strong mirror field for a field-reversed configuration (FRC) with the Thick Edge-Layer plasma

International Nuclear Information System (INIS)

Suzuki, Yukihisa; Okada, Shigefumi; Goto, Seiichi

2003-01-01

Modification of the magnetic field structure in the vicinity of the x-points and changes of the separatrix shape are investigated under the pressure effects due to an edge-layer plasma together with a mirror field by the two-dimensional (2-D) MHD equilibrium solutions of field-reversed configuration (FRC) obtained from the Grad-Shafranov equation. To explore the coupling pressure effects caused by edge-layer plasma and mirror field, the equilibrium calculations are performed by the combinations of several values of mirror ratio (R m ) and of edge-layer width (δ), respectively. A summary of results for present study is as follows. In the condition of weak mirror field (1.0 m m > 1.6, ψ=0 surface never opens up for any δ. These original results make it clear that large magnetic curvature produced by the strong mirror field enhances the magnetic stress around the x-point, so that the ends of FRC are effectively sustained by this enhanced magnetic stress, which counteracts the edge-layer plasma pressure effect. (author)

Analyses of plasma parameter profiles in JT-60U

International Nuclear Information System (INIS)

Shirai, Hiroshi; Shimizu, Katsuhiro; Hayashi, Nobuhiko

2001-01-01

The methods how diagnostics data are treated as the surface quantity of magnetic surface and processed to the profile data in the JT-60U plasmas are summarized. The MHD equilibrium obtained by solving Grad-Shafranov equation on the MHD equilibrium calculation and registration software FBEQU are saved shot by shot as a database. Various experimental plasma data measured at various geometrical positions on JT-60 are mapped onto the MHD equilibrium and treated as functions of the volume averaged minor radius ρ on the experimental data time slice monitoring software SLICE. Experimental data are integrated and edited on SLICE. The experimental data measured as the line integral values are transformed by Able inversion. The mapped data are fitted to a functional form and saved to the profile database MAP-DB. SLICE can also read data from MAP-DB and redisplay and transform them. In addition, SLICE can generate the profile data TOKRD as run data for orbit following Monte-Carlo (OFMC) code, analyzer for current drive consistent with MHD equilibrium (ACCOME) code and tokamak predictive and interpretive code system (TOPICS). (author)

ELLIPT2D: A Flexible Finite Element Code Written Python

International Nuclear Information System (INIS)

Pletzer, A.; Mollis, J.C.

2001-01-01

The use of the Python scripting language for scientific applications and in particular to solve partial differential equations is explored. It is shown that Python's rich data structure and object-oriented features can be exploited to write programs that are not only significantly more concise than their counter parts written in Fortran, C or C++, but are also numerically efficient. To illustrate this, a two-dimensional finite element code (ELLIPT2D) has been written. ELLIPT2D provides a flexible and easy-to-use framework for solving a large class of second-order elliptic problems. The program allows for structured or unstructured meshes. All functions defining the elliptic operator are user supplied and so are the boundary conditions, which can be of Dirichlet, Neumann or Robbins type. ELLIPT2D makes extensive use of dictionaries (hash tables) as a way to represent sparse matrices.Other key features of the Python language that have been widely used include: operator over loading, error handling, array slicing, and the Tkinter module for building graphical use interfaces. As an example of the utility of ELLIPT2D, a nonlinear solution of the Grad-Shafranov equation is computed using a Newton iterative scheme. A second application focuses on a solution of the toroidal Laplace equation coupled to a magnetohydrodynamic stability code, a problem arising in the context of magnetic fusion research

1-D hybrid code for FRM dynamics

International Nuclear Information System (INIS)

Stark, R.A.; Miley, G.H.

1985-01-01

A 1-D radial hybrid code has been written to study the start-up of the FRM via neutral-beam injection. This code, named FROST (Field Reversed One-dimensional STart-up), models the plasma as azimuthal symmetric with no axial dependence. A multi-group method in energy and canonical angular momentum describes the large-orbit ions from the beam. This method is designed to be more efficient than those employing particle tracking, since the characteristic timescale of the simulation is the ion slowing down time, rather than the much shorter cyclotron period. A time-differentiated Grad-Shafranov equation couples the ion current to massless fluid equations describing electrons and low energy ions. Flux coordinates are used in this fluid model, in preference to an Eulerian framework, so that coupling of plasma at the two different radii of a closed flux surface may be treated with ease. Since a fluid treatment for electrons is invalid near a field null, a separate model for the electron current has been included for this region, a unique feature. Results of simulation of injection into a 2XIIB-like plasma are discussed. Electron currents are found to retard, but not prevent reversal of the magnetic field at the plasma center

Evaluation of Two Guralp Preamplifiers for GS13 Seismometer Application.

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-09-01

Sandia National Laboratories has tested and evaluated a new preamplifier, the Guralp Preamplifier for GS13, manufactured by Guralp. These preamplifiers are used to interface between Guralp digitizers and Geotech GS13 Seismometers. The purpose of the preamplifier evaluation was to measure the performance characteristics in such areas as power consumption, input impedance, sensitivity, full scale, self-noise, dynamic range, system noise, response, passband, and timing. The Guralp GS13 Preamplifiers are being evaluated for potential use in the International Monitoring System (IMS) of the Comprehensive Nuclear Test-Ban-Treaty Organization (CTBTO).

Relativistic dissipative hydrodynamic equations at the second order for multi-component systems with multiple conserved currents

International Nuclear Information System (INIS)

Monnai, Akihiko; Hirano, Tetsufumi

2010-01-01

We derive the second order hydrodynamic equations for the relativistic system of multi-components with multiple conserved currents by generalizing the Israel-Stewart theory and Grad's moment method. We find that, in addition to the conventional moment equations, extra moment equations associated with conserved currents should be introduced to consistently match the number of equations with that of unknowns and to satisfy the Onsager reciprocal relations. Consistent expansion of the entropy current leads to constitutive equations which involve the terms not appearing in the original Israel-Stewart theory even in the single component limit. We also find several terms which exhibit thermal diffusion such as Soret and Dufour effects. We finally compare our results with those of other existing formalisms.

Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor

DEFF Research Database (Denmark)

Boyhus, Lotte Emilie; Danielsen, Mia; Bengtson, Nina Smidt

2018-01-01

A series of Gs protein peptidomimetics were designed and synthesised based on the published X-ray crystal structure of the active state β2-Adrenergic receptor (β2AR) in complex with the Gs protein (PDB 3SN6). We hypothesised that such peptidomimetics may function as allosteric modulators...... that target the intracellular Gs protein binding site of the β2AR. Peptidomimetics were designed to mimic the 15 residue C-Terminal α-helix of the Gs protein and were pre-organised in a helical conformation by (i, i + 4)-stapling using copper catalysed azide alkyne cycloaddition. Linear and stapled...... be able to compete with the native Gs protein for the intracellular binding site to block ISO-induced cAMP formation, but are unable to stabilise an active-like receptor conformation....

FiGS: a filter-based gene selection workbench for microarray data

Directory of Open Access Journals (Sweden)

Yun Taegyun

2010-01-01

Full Text Available Abstract Background The selection of genes that discriminate disease classes from microarray data is widely used for the identification of diagnostic biomarkers. Although various gene selection methods are currently available and some of them have shown excellent performance, no single method can retain the best performance for all types of microarray datasets. It is desirable to use a comparative approach to find the best gene selection result after rigorous test of different methodological strategies for a given microarray dataset. Results FiGS is a web-based workbench that automatically compares various gene selection procedures and provides the optimal gene selection result for an input microarray dataset. FiGS builds up diverse gene selection procedures by aligning different feature selection techniques and classifiers. In addition to the highly reputed techniques, FiGS diversifies the gene selection procedures by incorporating gene clustering options in the feature selection step and different data pre-processing options in classifier training step. All candidate gene selection procedures are evaluated by the .632+ bootstrap errors and listed with their classification accuracies and selected gene sets. FiGS runs on parallelized computing nodes that capacitate heavy computations. FiGS is freely accessible at http://gexp.kaist.ac.kr/figs. Conclusion FiGS is an web-based application that automates an extensive search for the optimized gene selection analysis for a microarray dataset in a parallel computing environment. FiGS will provide both an efficient and comprehensive means of acquiring optimal gene sets that discriminate disease states from microarray datasets.

Futur d'une infrastructure de correction automatisée : CodeGradX

OpenAIRE

Queinnec , Christian; Pons , Olivier

2016-01-01

Cet article évoque quelques expériences et nouvelles idées au-tour d'une infrastructure de correction automatisée de programmes. CodeGradX est une infrastructure de correction automatisée de programmes. Elle est en service depuis 2008 (initialement sous le nom de FW4EX) et a depuis corrigé plus de 150 000 soumissions d'étudiants à des exercices principalement en Scheme, utilitaires d'Unix, JavaScript mais aussi en C, Octave, O'Caml, Python sans oublier les compétitions annuelles des Journées ...

A 2-GS/s 6-bit self-calibrated flash ADC

Energy Technology Data Exchange (ETDEWEB)

Zhang Youtao; Chen Chen [National Key Laboratory of Monolithic Integrated Circuits and Modules, Nanjing Electronic Devices Institute, Nanjing 210016 (China); Li Xiaopeng; Zhang Min; Liu Ao, E-mail: zhangyt@nedc-ic.co [Nanjing Electronic Devices Institute, Nanjing 210016 (China)

2010-09-15

A single channel 2-GS/s 6-bit ADC with cascade resistive averaging and self foreground calibration is demonstrated in 0.18-{mu}m CMOS. The calibration method based on DAC trimming improves the linearity and dynamic performance further. The peak DNL and INL are measured as 0.34 and 0.22 LSB, respectively. The SNDR and SFDR have achieved 36.5 and 45.9 dB, respectively, with 1.22 MHz input signal and 2 GS/s. The proposed ADC, including on-chip track-and-hold amplifiers and clock buffers, consumes 570 mW from a single 1.8 V supply while operating at 2 GS/s. (semiconductor integrated circuits)

Specific requirements of GS-R3 related to process implementation

International Nuclear Information System (INIS)

Florescu, N.

2009-01-01

The PowerPoint presentation gives: an overview of IAEA management system requirements or topics; - the requirements specific to processes and process implementation; - the key practical challenge of using the process approach specified in IAEA SG GS-G3.1 and GS-G3.5. The following items are thoroughly discussed: - Requirements related to specific process implementation and developing processes; - Process management; Generic management; - System processes: - Control of documents; Control of products; Control of records; - Purchasing; - Communication; - Managing organizational change; - Other requirements concerning the process management system; - General management system; - Grading; - Documentation; - Fulfilling the requirements of interested parties; - Management responsibility; - Planning responsibility and authority for the management system monitoring and measurement; - Independent assessment; - Management system review; - Non-conformances, corrective and preventive actions; - Improvement key practical challenge of using the process approach specified in IAEA SG GS-G3.1 and GS-G3.5; - Key challenge: - Process common to all stages; - Phases of process development proposed by IAEA. The following conclusions complete the presentation: GS-R-3 sets basic requirements for process-based integrated management system; - Some key generic processes required, no specific process model favoured namely, no reference to management, core and support processes; - Up to organization to determine appropriate process model; - Easily applicable to a wide range of facilities and activities, including those of a regulatory body; - Specific requirements are found in specific Safety Guide. (author)

The convergence of analytic high-β equilibrium in a finite aspect ratio tokamak

International Nuclear Information System (INIS)

Neches, R. Y.; Cowley, S. C.; Gourdain, P. A.; Leboeuf, J. N.

2008-01-01

The characteristics of near-unity-β equilibria are investigated with two codes. CUBE is a multigrid Grad-Shafranov solver [Gourdain et al., J. Comput. Phys. 216, 275 (2006)], and Ophidian was written to compute solutions using analytic unity-β equilibria [Cowley et al., Phys. Fluids B 3, 2066 (1991)]. Results from each method are qualitatively and quantitatively compared across a spectrum of mutually relevant parameters. These comparisons corroborate the theoretical results and provide benchmarks for high-resolution numerical results available from CUBE. Both tools facilitate the exploration of the properties of high-β equilibria, such as a highly diamagnetic plasma and its ramifications for stability and transport.

Verification tests for GRAD, a computer program to predict nonuniform deformation and failure of Zr-2.5 wt percent Nb pressure tubes during a postulated loss-of-coolant accident

International Nuclear Information System (INIS)

Shewfelt, R.S.W.; Godin, D.P.

1985-03-01

During a postulated loss-of-coolant accident in a CANDU reactor, the temperature of the pressure tubes could rise sufficiently so that ballooning could occur. It is also likely that there would be a variation in temperature around the tube circumference, causing the deformation to be nonuniform. Since the deformation of the pressure tube controls how the core heat is transferred to the surrounding moderator, which is a large heat sink, a computer program, GRAD, has been developed to predict this nonuniform deformation. Numerous biaxial creep tests were done, where the temperature of internally pressurized sections of Zr-2.5 wt percent Nb pressure tubes were ramped to check the ability of GRAD to predict the resulting nonuniform deformation and possible tube failure. GRAD was successful in predicting the average transverse creep strain observed during the tests and the local transverse creep strain at the end of the tests. GRAD was also able to predict the failure time and average transverse creep strain at failure for all the specimens that failed

Docosahexaenoic acid alters Gsα localization in lipid raft and potentiates adenylate cyclase.

Science.gov (United States)

Zhu, Zhuoran; Tan, Zhoubin; Li, Yan; Luo, Hongyan; Hu, Xinwu; Tang, Ming; Hescheler, Jürgen; Mu, Yangling; Zhang, Lanqiu

2015-01-01

Supplementation with docosahexaenoic acid (DHA), an ω-3 polyunsaturated fatty acid (PUFA), recently has become popular for the amelioration of depression; however the molecular mechanism of DHA action remains unclear. The aim of this study was to investigate the mechanism underlying the antidepressant effect of DHA by evaluating Gsα localization in lipid raft and the activity of adenylate cyclase in an in vitro glioma cell model. Lipid raft fractions from C6 glioma cells treated chronically with DHA were isolated by sucrose gradient ultracentrifugation. The content of Gsα in lipid raft was analyzed by immunoblotting and colocalization of Gsα with lipid raft was subjected to confocal microscopic analysis. The intracellular cyclic adenosine monophosphate (cAMP) level was determined by cAMP immunoassay kit. DHA decreased the amount of Gsα in lipid raft, whereas whole cell lysate Gsα was not changed. Confocal microscopic analysis demonstrated that colocalization of Gsα with lipid raft was decreased, whereas DHA increased intracellular cAMP accumulation in a dose-dependent manner. Interestingly, we found that DHA increased the lipid raft level, instead of disrupting it. The results of this study suggest that DHA may exert its antidepressant effect by translocating Gsα from lipid raft and potentiating the activity of adenylate cyclase. Importantly, the reduced Gsα in lipid raft by DHA is independent of disruption of lipid raft. Overall, the study provides partial preclinical evidence supporting a safe and effective therapy using DHA for depression. Copyright © 2015 Elsevier Inc. All rights reserved.

On the kinetic theory of a fully ionized gas

International Nuclear Information System (INIS)

Bezerra Junior, A.G.; Rodbard, M.G.; Kremer, G.M.

1993-01-01

An alternative method for kinetic theory recently proposed, that combines the features of the Chapman-Enskog and Grad methods, neither using a solution of the integral equation nor the field equations of the moments, is applied to ionized gases. Like in the Grad method, the deviation from equilibrium of the moments are used. Like in the method of Grad, the deviation from equilibrium of the distribution function is written in terms of the moments of the distribution function, but the constitutive equations follow direct from the Boltzmann equation through the Chapman-Enskog method. (author)

Complex of GRAD programs for analytical calculation of radiation defects generation in solids

International Nuclear Information System (INIS)

Suvorov, A.L.; Zabolotnyj, V.T.; Babaev, V.P.

1989-01-01

Complex of programms for analytical calculation of generation of radiation defects (GRAD) in solids, and also of their recombination during cascade area relaxation and postradiation annealing, of mass removing by atomic collisions in volume (mixing) and through the surface (sputtering), of structure - phase state and property changes is suggested. The complex volume is less than 10 KBytes and it may be realized by computer of any type. Satisfactional agreement with more wide range of experimental data in comparison with tradition models is obtained. 27 refs.; 2 figs

Equations for the gravitational field and local conserved quantities in the general theory of relativity

International Nuclear Information System (INIS)

Manoff, S.

1979-07-01

By utilization of the method of Lagrangians with covariant derivatives (MLCD) the different energy-momentum tensors (canonical, generalized canonical, symmetrical) and the relations between them are considered. On this basis, Einstein's theory of gravitation is studied as a field theory with a Lagrangian density of the type Lsub(g)=√-g.Lsub(g)(gsub(ij),Rsub(A)), (Rsub(A)=Rsub(ijkl)). It is shown that the energy-momentum tensors of the gravitational field can be defined for this theory. The symmetrical energy-momentum tensor of the gravitational field sub(gs)Tsub(k)sup(i), which in the general case is not a local conserved quantity (sub(gs)Tsub(k)sup(i)sub(;i) unequal 0) (in contrast to the material fields satisfying condition sub(Ms)Tsub(k)sup(i)sub(;i) = 0), is equal to zero for the gravitational field in vacuum (cosmological constant Λ = 0). Equations of the gravitational field of a new type are suggested, leading to equations of motion (sub(Ms)Tsub(k)sup(i) + sub(gs)Tsub(k)sup(i))sub(;i) = 0. The equations corresponding to the Lagrangian density Lsub(g)=(√-g/kappasub(o)) (R - lambda approximately), lambda approximately = const., are considered. The equations of Einstein Rsub(ij) = 0 are obtained in the case of gravitational field in vacuum. Some particular cases are examined as an illustration to material fields and the corresponding gravitational equations. (author)

Solution adaptive triangular meshes with application to the simulation of plasma equilibrium

International Nuclear Information System (INIS)

Erlebacher, G.

1984-01-01

A new discrete Laplace operator is constructed on a local mesh molecule, second order accurate on symmetric cell regions, based on local Taylor series expansions. This discrete Laplacian is then compared to the one commonly used in the literature. A truncation error analysis of gradient and Laplace operators calculated at triangle centroids reveals that the maximum bounds of their truncation errors are minimized on equilateral triangles, for a fixed triangle perimeter. A new adaptive strategy on arbitrary triangular grids is developed in which a uniform grid is defined with respect to the solution surface, as opposed to the x,y plane. Departures from mesh uniformity arises from a spacially dependent mean-curvature of the solution surface. The power of this new adaptive technique is applied to the problem of finding free-boundary plasma equilibria within the context of MHD. The geometry is toroidal, and axisymmetry in the toroidal direction is assumed. We are led to conclude that the grid should move, not towards regions of high curvature of magnetic flux, but rather towards regions of greater toroidal current density. This has a direct bearing on the accuracy with which the Grad-Shafranov equation is being approximated

NSTX Diagnostics for Fusion Plasma Science Studies

International Nuclear Information System (INIS)

Kaita, R.; Johnson, D.; Roquemore, L.; Bitter, M.; Levinton, F.; Paoletti, F.; Stutman, D.

2001-01-01

This paper will discuss how plasma science issues are addressed by the diagnostics for the National Spherical Torus Experiment (NSTX), the newest large-scale machine in the magnetic confinement fusion (MCF) program. The development of new schemes for plasma confinement involves the interplay of experimental results and theoretical interpretations. A fundamental requirement, for example, is a determination of the equilibria for these configurations. For MCF, this is well established in the solutions of the Grad-Shafranov equation. While it is simple to state its basis in the balance between the kinetic and magnetic pressures, what they are as functions of space and time are often not easy to obtain. Quantities like the plasma pressure and current density are not directly measurable. They are derived from data that are themselves complex products of more basic parameters. The same difficulties apply to the understanding of plasma instabilities. Not only are the needs for spatial and temporal resolution more stringent, but the wave parameters which characterize the instabilities are difficult to resolve. We will show how solutions to the problems of diagnostic design on NSTX, and the physics insight the data analysis provides, benefits both NSTX and the broader scientific community

Investigation of internal magnetic structures and comparison with two-fluid equilibrium configurations in the multi-pulsing CHI on HIST

Science.gov (United States)

Nakayama, T.; Hanao, T.; Hirono, H.; Hyobu, T.; Ito, K.; Matsumoto, K.; Kikuchi, Y.; Fukumoto, N.; Nagata, M.; Kanki, T.

2012-10-01

Spherical torus (ST) plasmas have been successfully maintained by Muti-pulsing Coaxial Helicity Injection (M-CHI) on HIST. This research object is to clarify relations between plasma characteristics and magnetic flux amplifications, and to compare magnetic field structures measured in the plasma interior to a flowing equilibrium calculation. Two-dimensional magnetic probe array has been newly introduced nearby the gun muzzle. The initial result shows that the diverter configuration with a single X-point can be formed after a bubble burst process of the plasma. The closed magnetic flux is surrounded by the open magnetic field lines intersecting with the gun electrodes. To evaluate the sustained configurations, we use the two-fluid equilibrium code containing generalized Bernoulli and Grad-Shafranov equations which was developed by L.C. Steinhauer. The radial profiles of plasma flow, density and magnetic fields measured on the midplane of the FC are consistent to the calculation. We also found that the poloidal shear flow generation is attributed to ExB drift and ion diamagnetic drift. In addition, we will study temporal behaviors of impurity lines such as OV and OVI during the flux amplification by VUV spectroscopic measurements.

Equilibrium reconstruction in the TCA/Br tokamak

International Nuclear Information System (INIS)

Sa, Wanderley Pires de

1996-01-01

The accurate and rapid determination of the Magnetohydrodynamic (MHD) equilibrium configuration in tokamaks is a subject for the magnetic confinement of the plasma. With the knowledge of characteristic plasma MHD equilibrium parameters it is possible to control the plasma position during its formation using feed-back techniques. It is also necessary an on-line analysis between successive discharges to program external parameters for the subsequent discharges. In this work it is investigated the MHD equilibrium configuration reconstruction of the TCA/BR tokamak from external magnetic measurements, using a method that is able to fast determine the main parameters of discharge. The thesis has two parts. Firstly it is presented the development of an equilibrium code that solves de Grad-Shafranov equation for the TCA/BR tokamak geometry. Secondly it is presented the MHD equilibrium reconstruction process from external magnetic field and flux measurements using the Function Parametrization FP method. this method. This method is based on the statistical analysis of a database of simulated equilibrium configurations, with the goal of obtaining a simple relationship between the parameters that characterize the equilibrium and the measurements. The results from FP are compared with conventional methods. (author)

PC-based package for interactive assessment of MHD equilibrium and poloidal field coil design in axisymmetric toroidal geometry

International Nuclear Information System (INIS)

Kelleher, W.P.

1987-01-01

In the assessment of Magnetohydrodynamic (MHD) equilibrium and Poloidal Field Coil (PFC) arrangement for toroidal axisymmetric geometry, the Grad-Shafranov equation must be solved, either analytically or numerically. Existing numerical tools have been developed primarily for mainframe usage and can prove cumbersome for screening assessments and parametric evaluations. The objective of this thesis was to develop a personal computer (PC)-based calculational tool for assessing MHD/PFC problems in a highly interactive mode, well suited for scoping studies. The approach adopted involves a two-step process: first the MHD equilibrium is calculated and then the PFC arrangement, consistent with the equilibrium, is determined in an interactive design environment. The PC-based system developed consists of two programs: (1) PCEQ, which solve the MHD equilibrium problem and (2) PFDE-SIGN, which is employed to arrive at a PFC arrangement. PCEQ provides an output file including, but not limited to, the following: poloidal beta, total beta, safety factors, q, on axis and on edge. PCEQ plots the following contours and/or profiles: flux, pressure and toroidal current density, safety factor, and ratio of plasma toroidal field to vacuum field

Crystal structure of the β2 adrenergic receptor-Gs protein complex

DEFF Research Database (Denmark)

Rasmussen, Søren Gøgsig Faarup; DeVree, Brian T; Zou, Yaozhong

2011-01-01

-occupied receptor. The β(2) adrenergic receptor (β(2)AR) activation of Gs, the stimulatory G protein for adenylyl cyclase, has long been a model system for GPCR signalling. Here we present the crystal structure of the active state ternary complex composed of agonist-occupied monomeric β(2)AR and nucleotide-free Gs...

French language: A basic G.S course for Nnamdi Azikiwe University ...

African Journals Online (AJOL)

Descriptive method was adopted for the study and data were collected from articles, internet sources and interview. The finding indicated that some universities have adopted French as one of the GS courses. It suggested that French language be taught in UNIZIK as a GS course. The work was based on NUC benchmark ...

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic. Annual Update, 2012

Science.gov (United States)

Balfanz, Robert; Bridgeland, John M.; Bruce, Mary; Fox, Joanna Hornig

2012-01-01

In 2010, the authors shared a Civic Marshall Plan to create a Grad Nation. Through that first report and subsequent update, they saw hopeful signs of progress in boosting high school graduation rates in communities across the country. This 2012 report shows that high school graduation rates continue to improve nationally and across many states and…

A Rare Allele of GS2 Enhances Grain Size and Grain Yield in Rice.

Science.gov (United States)

Hu, Jiang; Wang, Yuexing; Fang, Yunxia; Zeng, Longjun; Xu, Jie; Yu, Haiping; Shi, Zhenyuan; Pan, Jiangjie; Zhang, Dong; Kang, Shujing; Zhu, Li; Dong, Guojun; Guo, Longbiao; Zeng, Dali; Zhang, Guangheng; Xie, Lihong; Xiong, Guosheng; Li, Jiayang; Qian, Qian

2015-10-05

Grain size determines grain weight and affects grain quality. Several major quantitative trait loci (QTLs) regulating grain size have been cloned; however, our understanding of the underlying mechanism that regulates the size of rice grains remains fragmentary. Here, we report the cloning and characterization of a dominant QTL, grain size on chromosome 2 (GS2), which encodes Growth-Regulating Factor 4 (OsGRF4), a transcriptional regulator. GS2 localizes to the nucleus and may act as a transcription activator. A rare mutation of GS2 affecting the binding site of a microRNA, OsmiR396c, causes elevated expression of GS2/OsGRF4. The increase in GS2 expression leads to larger cells and increased numbers of cells, which thus enhances grain weight and yield. The introduction of this rare allele of GS2/OsGRF4 into rice cultivars could significantly enhance grain weight and increase grain yield, with possible applications in breeding high-yield rice varieties. Copyright © 2015 The Author. Published by Elsevier Inc. All rights reserved.

Haplotypes of the TaGS5-A1 gene are associated with thousand-kernel weight in Chinese bread wheat

Directory of Open Access Journals (Sweden)

Wang Sha Sha

2016-06-01

Full Text Available In previous work, we cloned TaGS5 gene and found the association of TaGS5-A1 alleles with agronomic traits. In this study, the promoter sequence of the TaGS5-A1 gene was isolated from bread wheat. Sequencing results revealed that a G insertion was found in position -1925 bp of the TaGS5-A1 gene (Reference to ATG, which occurred in the Sp1 domain of the promoter sequence. Combined with previous single nucleotide polymorphism (SNP in the TaGS5-A1 exon sequence, four genotypes were formed at the TaGS5-A1 locus and were designated as TaGS5-A1a-a, TaGS5-A1a-b, TaGS5-A1b-a, and TaGS5-A1b-b, respectively. Analysis of the association of TaGS5-A1 alleles with agronomic traits indicated that cultivars with the TaGS5-A1a-b allele possessed significantly higher thousand-kernel weight (TKW and lower plant height than cultivars with the TaGS5-A1a-a allele, and cultivars with the TaGS5-A1b-b allele showed higher TKW than cultivars with the TaGS5-A1b-a allele. The differences of these traits between the TaGS5-A1a-a and TaGS5-A1a-b alleles were larger than those of the TaGS5-A1b-a and TaGS5-A1b-b alleles, suggesting that the -1925G insertion plays the more important role in TaGS5-A1a genotypes than in TaGS5-A1b genotypes. qRT-PCR indicated that TaGS5-A1b-b possessed the significantly highest expression level among four TaGS5-A1 haplotypes in mature seeds and further showed a significantly higher expression level than TaGS5-A1b-a at five different developmental stages of the seeds, suggesting that high expression of TaGS5-A1 was positively associated with high TKW in bread wheat. This study could provide a relatively superior genotype in view of TKW in wheat breeding programs and could also provide important information for dissection of the regulatory mechanism of the yield-related traits.

TaGS5-3A, a grain size gene selected during wheat improvement for larger kernel and yield.

Science.gov (United States)

Ma, Lin; Li, Tian; Hao, Chenyang; Wang, Yuquan; Chen, Xinhong; Zhang, Xueyong

2016-05-01

Grain size is a dominant component of grain weight in cereals. Earlier studies have shown that OsGS5 plays a major role in regulating both grain size and weight in rice via promotion of cell division. In this study, we isolated TaGS5 homoeologues in wheat and mapped them on chromosomes 3A, 3B and 3D. Temporal and spatial expression analysis showed that TaGS5 homoeologues were preferentially expressed in young spikes and developing grains. Two alleles of TaGS5-3A, TaGS5-3A-T and TaGS5-3A-G were identified in wheat accessions, and a functional marker was developed to discriminate them. Association analysis revealed that TaGS5-3A-T was significantly correlated with larger grain size and higher thousand kernel weight. Biochemical assays showed that TaGS5-3A-T possesses a higher enzymatic activity than TaGS5-3A-G. Transgenic rice lines overexpressing TaGS5-3A-T also exhibited larger grain size and higher thousand kernel weight than TaGS5-3A-G lines, and the transcript levels of cell cycle-related genes in TaGS5-3A-T lines were higher than those in TaGS5-3A-G lines. Furthermore, systematic evolution analysis in diploid, tetraploid and hexaploid wheat showed that TaGS5-3A underwent strong artificial selection during wheat polyploidization events and the frequency changes of two alleles demonstrated that TaGS5-3A-T was favoured in global modern wheat cultivars. These results suggest that TaGS5-3A is a positive regulator of grain size and its favoured allele TaGS5-3A-T exhibits a larger potential application in wheat high-yield breeding. © 2015 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

Ectopic Expression of GsSRK in Medicago sativa Reveals Its Involvement in Plant Architecture and Salt Stress Responses.

Science.gov (United States)

Sun, Mingzhe; Qian, Xue; Chen, Chao; Cheng, Shufei; Jia, Bowei; Zhu, Yanming; Sun, Xiaoli

2018-01-01

Receptor-like kinases (RLK) play fundamental roles in plant growth and stress responses. Compared with other RLKs, little information is provided concerning the S-locus LecRLK subfamily, which is characterized by an extracellular G-type lectin domain and an S-locus-glycop domain. Until now, the function of the G-type lectin domain is still unknown. In a previous research, we identified a Glycine soja S-locus LecRLK gene GsSRK , which conferred increased salt stress tolerance in transgenic Arabidopsis . In this study, to investigate the role of the G-type lectin domain and to breed transgenic alfalfa with superior salt stress tolerance, we transformed the full-length GsSRK ( GsSRK-f ) and a truncated version of GsSRK ( GsSRK-t ) deleting the G-type lectin domain into alfalfa. Our results showed that overexpression of GsSRK-t , but not GsSRK-f , resulted in changes of plant architecture, as evidenced by more branches but shorter shoots of GsSRK-t transgenic alfalfa, indicating a potential role of the extracellular G-type lectin domain in regulating plant architecture. Furthermore, we also found that transgenic alfalfa overexpressing either GsSRK-f or GsSRK-t showed increased salt stress tolerance, and GsSRK-t transgenic alfalfa displayed better growth (more branches and higher fresh weight) than GsSRK-f lines under salt stress. In addition, our results suggested that both GsSRK-f and GsSRK-t were involved in ion homeostasis, ROS scavenging, and osmotic regulation. Under salt stress, the Na + content in the transgenic lines was significantly lower, while the K + content was slightly higher than that in WT. Moreover, the transgenic lines displayed reduced ion leakage and MDA content, but increased SOD activity and proline content than WT. Notably, no obvious difference in these physiological indices was observed between GsSRK-f and GsSRK-t transgenic lines, implying that deletion of the GsSRK G-type lectin domain does not affect its physiological function in salt

Efficient augmented Lagrangian-type preconditioning for the Oseen problem using Grad-Div stabilization

KAUST Repository

Heister, Timo

2012-01-29

Efficient preconditioning for Oseen-type problems is an active research topic. We present a novel approach leveraging stabilization for inf-sup stable discretizations. The Grad-Div stabilization shares the algebraic properties with an augmented Lagrangian-type term. Both simplify the approximation of the Schur complement, especially in the convection-dominated case. We exploit this for the construction of the preconditioner. Solving the discretized Oseen problem with an iterative Krylov-type method shows that the outer iteration numbers are retained independent of mesh size, viscosity, and finite element order. Thus, the preconditioner is very competitive. © 2012 John Wiley & Sons, Ltd.

Efficient augmented Lagrangian-type preconditioning for the Oseen problem using Grad-Div stabilization

KAUST Repository

Heister, Timo; Rapin, Gerd

2012-01-01

Efficient preconditioning for Oseen-type problems is an active research topic. We present a novel approach leveraging stabilization for inf-sup stable discretizations. The Grad-Div stabilization shares the algebraic properties with an augmented Lagrangian-type term. Both simplify the approximation of the Schur complement, especially in the convection-dominated case. We exploit this for the construction of the preconditioner. Solving the discretized Oseen problem with an iterative Krylov-type method shows that the outer iteration numbers are retained independent of mesh size, viscosity, and finite element order. Thus, the preconditioner is very competitive. © 2012 John Wiley & Sons, Ltd.

Notes from the church of the Virgin at the island of Mali grad

Directory of Open Access Journals (Sweden)

Cvetkovski Sašo

2010-01-01

Full Text Available In this text the unknown parts of the wall paintings from the Church of the Virgin at the island of Mali Grad (The Great Prespa Lake are analyzed: the figure of a monk praying to St. Paraskeve, on the southern wall of the nave, as well as the painting on the southern faüade with the depictions of St. George on horseback, the Virgin as Empress enthroned, and the bust of two saints, St. Paraskeve and St. Nicholas. The monk is identified with the hegoumenos Jona, mentioned in the donor’s inscription dating from 1369.

Correspondence of ISO 9001:2008 with IAEA GS-R-3

International Nuclear Information System (INIS)

Kibrit, Eduardo

2009-01-01

This article identifies, characterises and analyses International Organisation for Standardisation (ISO) and International Atomic Energy Agency (IAEA) normative requirements for the development and implementation of quality management systems in nuclear organisations. The structures of the applicable standards, ISO 9001:2008 and IAEA GS-R-3, are characterised. The differences and similarities of objective, focus, scope, level of application, structure, vocabulary, management system, management responsibility, resource management, process implementation, measurement, assessment and improvement verified in the applicable standards are deeply reviewed. A correspondence of the applicable standards' requirements is presented topic by topic. A correlation of the applicable standards' requirements is made, showing IAEA GS-R-3 topics that have no correlation with ISO 9001:2008 and ISO 9001:2008 topics that have no correlation with IAEA GS-R-3. Conclusive remarks advise the pros and cons of using one of the applicable standards or the other. (author)

Summoning earth and fire: The energy development implications of Grameen Shakti (GS) in Bangladesh

International Nuclear Information System (INIS)

Sovacool, Benjamin K.; Drupady, Ira Martina

2011-01-01

Since its establishment in 1996, the nonprofit company Grameen Shakti (GS) has installed almost half a million solar home systems (SHS), 132,000 cookstoves, and 13,300 biogas plants among 3.1 million beneficiaries. They plan to ramp up their expansion so that by 2015, more than 1.5 million SHS are in place along with 100,000 biogas units and 5 million improved cookstoves. This article describes GS's current activities, the contours of its programs, and likely reasons for its success. It also explores the remaining challenges facing GS and distils common lessons for other energy development assistance projects and programs around the world. After detailing research methods consisting primarily of research interviews and site visits, the article briefly explores the history of GS and summarizes its three most prominent programs. The article then identifies six distinct benefits to their programs-expansion of energy access, less deforestation and fewer greenhouse gas emissions, price savings, direct employment and income generation, improved public health, and better technology-before discussing challenges related to staff retention and organizational growth, living standards, technical obstacles, affordability, tension with other energy programs, political constraints, and awareness and cultural values. -- Highlights: → Grameen Shakti (GS) has installed a large number of solar home systems (SHS), cookstoves, and biogas plants. → GS programs have brought a wide array of social and economic benefits. → GS programs face internal and external challenges if they are to remain successful.

Behinds the scenes of GS: a DSO like no other

CERN Multimedia

Antonella Del Rosso

2014-01-01

At CERN, Departmental Safety Officers (DSOs) are responsible for making the members of their department aware of safety issues. They’re our first point of call every time a problem arises relating to environmental matters or the safety of people and installations. In GS, this role is even more crucial as the Department’s activities are scattered across the Laboratory and affect everyone.   As we have pointed out in our article series "Behind the scenes of GS”, the GS Department is responsible for the construction, renovation and maintenance of buildings and related technical infrastructures. The latter include heating and toilet facilities; detection and alarm systems; the management of the hotels, stores, stocks, shuttle services and mail; and the development of technical and administrative databases. The activities of the Medical Service and the Fire and Rescue Service also come under the umbrella of GS, as do the many other daily activities that are pa...

GS6, a member of the GRAS gene family, negatively regulates grain size in rice.

Science.gov (United States)

Sun, Lianjun; Li, Xiaojiao; Fu, Yongcai; Zhu, Zuofeng; Tan, Lubin; Liu, Fengxia; Sun, Xianyou; Sun, Xuewen; Sun, Chuanqing

2013-10-01

Grain size is an important yield-related trait in rice. Intensive artificial selection for grain size during domestication is evidenced by the larger grains of most of today's cultivars compared with their wild relatives. However, the molecular genetic control of rice grain size is still not well characterized. Here, we report the identification and cloning of Grain Size 6 (GS6), which plays an important role in reducing grain size in rice. A premature stop at the +348 position in the coding sequence (CDS) of GS6 increased grain width and weight significantly. Alignment of the CDS regions of GS6 in 90 rice materials revealed three GS6 alleles. Most japonica varieties (95%) harbor the Type I haplotype, and 62.9% of indica varieties harbor the Type II haplotype. Association analysis revealed that the Type I haplotype tends to increase the width and weight of grains more than either of the Type II or Type III haplotypes. Further investigation of genetic diversity and the evolutionary mechanisms of GS6 showed that the GS6 gene was strongly selected in japonica cultivars. In addition, a "ggc" repeat region identified in the region that encodes the GRAS domain of GS6 played an important historic role in the domestication of grain size in rice. Knowledge of the function of GS6 might aid efforts to elucidate the molecular mechanisms that control grain development and evolution in rice plants, and could facilitate the genetic improvement of rice yield. © 2013 Institute of Botany, Chinese Academy of Sciences.

Gq and Gs signaling acting in synergy to control GLP-1 secretion

DEFF Research Database (Denmark)

Pedersen, Maria Hauge; Ekberg, Jeppe Hvidtfeldt; Engelstoft, Maja Storm

2017-01-01

GPR40 is generally known to signal through Gq. However, in transfected cells, certain synthetic agonists can make the receptor signal also through Gs and cAMP (Hauge et al., 2015). Here we find that, in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 agonists is indeed i...

Derivation of Grad’s Thirteen Regularized Moment Equations Using a Hermite Polynomial Representation of Velocity Distribution Function (Preprint)

Science.gov (United States)

2010-06-16

B4) Substituting tui  / and tVT  /2 from the momentum and energy conservation law equations, Eqs...B9) Substituting tui  / and tVT  /2 from the momentum and energy conservation law equations, Eqs. (15...Substituting tui  / and tVT  /2 from the momentum and energy conservation law equations, Eqs. (15) and (16), into Eq. (B13) and then dropping all

Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis.

Science.gov (United States)

Feary, Marc; Racher, Andrew J; Young, Robert J; Smales, C Mark

2017-01-01

In Lonza Biologics' GS Gene Expression System™, recombinant protein-producing GS-CHOK1SV cell lines are generated by transfection with an expression vector encoding both GS and the protein product genes followed by selection in MSX and glutamine-free medium. MSX is required to inhibit endogenous CHOK1SV GS, and in effect create a glutamine auxotrophy in the host that can be complemented by the expression vector encoded GS in selected cell lines. However, MSX is not a specific inhibitor of GS as it also inhibits the activity of GCL (a key enzyme in the glutathione biosynthesis pathway) to a similar extent. Glutathione species (GSH and GSSG) have been shown to provide both oxidizing and reducing equivalents to ER-resident oxidoreductases, raising the possibility that selection for transfectants with increased GCL expression could result in the isolation of GS-CHOKISV cell lines with improved capacity for recombinant protein production. In this study we have begun to address the relationship between MSX supplementation, the amount of intracellular GCL subunit and mAb production from a panel of GS-CHOK1SV cell lines. We then evaluated the influence of reduced GCL activity on batch culture of an industrially relevant mAb-producing GS-CHOK1SV cell line. To the best of our knowledge, this paper describes for the first time the change in expression of GCL subunits and recombinant mAb production in these cell lines with the degree of MSX supplementation in routine subculture. Our data also shows that partial inhibition of GCL activity in medium containing 75 µM MSX increases mAb productivity, and its more specific inhibitor BSO used at a concentration of 80 µM in medium increases the specific rate of mAb production eight-fold and the concentration in harvest medium by two-fold. These findings support a link between the inhibition of glutathione biosynthesis and recombinant protein production in industrially relevant systems and provide a process-driven method for

0(gs)+ -->2(1)+ transition strengths in 106Sn and 108Sn.

Science.gov (United States)

Ekström, A; Cederkäll, J; Fahlander, C; Hjorth-Jensen, M; Ames, F; Butler, P A; Davinson, T; Eberth, J; Fincke, F; Görgen, A; Górska, M; Habs, D; Hurst, A M; Huyse, M; Ivanov, O; Iwanicki, J; Kester, O; Köster, U; Marsh, B A; Mierzejewski, J; Reiter, P; Scheit, H; Schwalm, D; Siem, S; Sletten, G; Stefanescu, I; Tveten, G M; Van de Walle, J; Van Duppen, P; Voulot, D; Warr, N; Weisshaar, D; Wenander, F; Zielińska, M

2008-07-04

The reduced transition probabilities, B(E2; 0(gs)+ -->2(1)+), have been measured in the radioactive isotopes (108,106)Sn using subbarrier Coulomb excitation at the REX-ISOLDE facility at CERN. Deexcitation gamma rays were detected by the highly segmented MINIBALL Ge-detector array. The results, B(E2;0(gs)+ -->2(1)+)=0.222(19)e2b2 for 108Sn and B(E2; 0(gs)+-->2(1)+)=0.195(39)e2b2 for 106Sn were determined relative to a stable 58Ni target. The resulting B(E2) values are approximately 30% larger than shell-model predictions and deviate from the generalized seniority model. This experimental result may point towards a weakening of the N=Z=50 shell closure.

Test Report : GS Battery, EPC power HES RESCU

Energy Technology Data Exchange (ETDEWEB)

Rose, David Martin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Schenkman, Benjamin L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Borneo, Daniel R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2013-10-01

The Department of Energy Office of Electricity (DOE/OE), Sandia National Laboratories (SNL) and the Base Camp Integration Lab (BCIL) partnered together to incorporate an energy storage system into a microgrid configured Forward Operating Base to reduce the fossil fuel consumption and to ultimately save lives. Energy storage vendors will be sending their systems to SNL Energy Storage Test Pad (ESTP) for functional testing and then to the BCIL for performance evaluation. The technologies that will be tested are electro-chemical energy storage systems comprising of lead acid, lithium-ion or zinc-bromide. GS Battery and EPC Power have developed an energy storage system that utilizes zinc-bromide flow batteries to save fuel on a military microgrid. This report contains the testing results and some limited analysis of performance of the GS Battery, EPC Power HES RESCU.

Charting a Path to Graduation. The Effect of Project GRAD on Elementary School Student Outcomes in Four Urban School Districts

Science.gov (United States)

Snipes, Jason C.; Holton, Glee Ivory; Doolittle, Fred

2006-01-01

In the past decade, school districts around the country have sought to improve struggling urban high schools, where high dropout rates, poor student achievement, and low rates of graduation and college-going remain all too prevalent. In a field crowded with reform initiatives, Project Graduation Really Achieves Dreams (GRAD) stands out as…

Real time equilibrium reconstruction for tokamak discharge control

International Nuclear Information System (INIS)

Ferron, J.R.; Walker, M.L.; Lao, L.L.; St John, H.E.; Humphreys, D.A.; Leuer, J.A.

1998-01-01

A practical method for performing a tokamak equilibrium reconstruction in real time for arbitrary time varying discharge shapes and current profiles is described. An approximate solution to the Grad-Shafranov equilibrium relation is found which best fits the diagnostic measurements. Thus, a solution for the spatial distribution of poloidal flux and toroidal current density is available in real time that is consistent with plasma force balance, allowing accurate evaluation of parameters such as discharge shape and safety factor profile. The equilibrium solutions are produced at a rate sufficient for discharge control. This equilibrium reconstruction algorithm has been implemented on the digital plasma control system for the DIII-D tokamak. The first application of real time equilibrium reconstruction to discharge shape control is described. (author)

GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice

International Nuclear Information System (INIS)

Hirose, Koichi; Wakashin, Hidefumi; Oki, Mie; Kagami, Shin-ichiro; Suto, Akira; Ikeda, Kei; Watanabe, Norihiko; Iwamoto, Itsuo; Furuichi, Yasuhiro; Nakajima, Hiroshi

2008-01-01

Asthma is characterized by airway inflammation with intense eosinophil infiltration and mucus hyper-production, in which antigen-specific Th2 cells play critical roles. Nuclear factor-κB (NF-κB) pathway has been demonstrated to be essential for the production of Th2 cytokines and chemokines in the airways in murine asthma models. In the present study, we examined the effect of GS143, a novel small-molecule inhibitor of IκB ubiquitination, on antigen-induced airway inflammation and Th2 cytokine production in mice. Intranasal administration of GS143 prior to antigen challenge suppressed antigen-induced NF-κB activation in the lung of sensitized mice. Intranasal administration of GS143 also inhibited antigen-induced eosinophil and lymphocyte recruitment into the airways as well as the expression of Th2 cytokines and eotaxin in the airways. Moreover, GS143 inhibited antigen-induced differentiation of Th2 cells but not of Th1 cells in vitro. Taken together, these results suggest that IκB ubiquitination inhibitor may have therapeutic potential against asthma

Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.

Science.gov (United States)

Niu, Congrong; Li, Li; Daffis, Stephane; Lucifora, Julie; Bonnin, Marc; Maadadi, Sarah; Salas, Eduardo; Chu, Ruth; Ramos, Hilario; Livingston, Christine M; Beran, Rudolf K; Garg, Abhishek V; Balsitis, Scott; Durantel, David; Zoulim, Fabien; Delaney, William E; Fletcher, Simon P

2018-05-01

GS-9620, an oral agonist of toll-like receptor 7 (TLR7), is in clinical development for the treatment of chronic hepatitis B (CHB). GS-9620 was previously shown to induce prolonged suppression of serum viral DNA and antigens in the woodchuck and chimpanzee models of CHB. Herein, we investigated the molecular mechanisms that contribute to the antiviral response to GS-9620 using in vitro models of hepatitis B virus (HBV) infection. Cryopreserved primary human hepatocytes (PHH) and differentiated HepaRG (dHepaRG) cells were infected with HBV and treated with GS-9620, conditioned media from human peripheral blood mononuclear cells treated with GS-9620 (GS-9620 conditioned media [GS-9620-CM]), or other innate immune stimuli. The antiviral and transcriptional response to these agents was determined. GS-9620 had no antiviral activity in HBV-infected PHH, consistent with low level TLR7 mRNA expression in human hepatocytes. In contrast, GS-9620-CM induced prolonged reduction of HBV DNA, RNA, and antigen levels in PHH and dHepaRG cells via a type I interferon (IFN)-dependent mechanism. GS-9620-CM did not reduce covalently closed circular DNA (cccDNA) levels in either cell type. Transcriptional profiling demonstrated that GS-9620-CM strongly induced various HBV restriction factors - although not APOBEC3A or the Smc5/6 complex - and indicated that established HBV infection does not modulate innate immune sensing or signaling in cryopreserved PHH. GS-9620-CM also induced expression of immunoproteasome subunits and enhanced presentation of an immunodominant viral peptide in HBV-infected PHH. Type I IFN induced by GS-9620 durably suppressed HBV in human hepatocytes without reducing cccDNA levels. Moreover, HBV antigen presentation was enhanced, suggesting additional components of the TLR7-induced immune response played a role in the antiviral response to GS-9620 in animal models of CHB. GS-9620 is a drug currently being tested in clinical trials for the treatment of chronic

New applications of Equinox code for real-time plasma equilibrium and profile reconstruction for tokamaks

International Nuclear Information System (INIS)

Bosak, K.; Blum, J.; Joffrin, E.

2004-01-01

Recent development of real-time equilibrium code Equinox using a fixed-point algorithm allow major plasma magnetic parameters to be identified in real-time, using rigorous analytical method. The code relies on the boundary flux code providing magnetic flux values on the first wall of vacuum vessel. By means of least-square minimization of differences between magnetic field obtained from previous solution and the next measurements the code identifies the source term of the non-linear Grad-Shafranov equation. The strict use of analytical equations together with a flexible algorithm offers an opportunity to include new measurements into stable magnetic equilibrium code and compare the results directly between several tokamaks while maintaining the same physical model (i.e. no iron model is necessary inside the equilibrium code). The successful implementation of this equilibrium code for JET and Tore Supra has already been published. In this paper, we show the preliminary results of predictive runs of the Equinox code using the ITER geometry. Because the real-time control experiments of plasma profile at JET using the code has been shown unstable when using magnetic and polarimetric measurements (that could be indirectly translated into accuracy vs robustness tradeoff), we plan an outline of the algorithm that will allow us to further constrain the plasma current profile using the central value of pressure of the plasma in real-time in order to better define the poloidal beta (this constraint is not necessary with purely magnetic equilibrium). (authors)

New applications of Equinox code for real-time plasma equilibrium and profile reconstruction for tokamaks

Energy Technology Data Exchange (ETDEWEB)

Bosak, K.; Blum, J. [Universite de Nice-Sophia-Antipolis, Lab. J. A. Dieudonne, 06 - Nice (France); Joffrin, E. [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

2004-07-01

Recent development of real-time equilibrium code Equinox using a fixed-point algorithm allow major plasma magnetic parameters to be identified in real-time, using rigorous analytical method. The code relies on the boundary flux code providing magnetic flux values on the first wall of vacuum vessel. By means of least-square minimization of differences between magnetic field obtained from previous solution and the next measurements the code identifies the source term of the non-linear Grad-Shafranov equation. The strict use of analytical equations together with a flexible algorithm offers an opportunity to include new measurements into stable magnetic equilibrium code and compare the results directly between several tokamaks while maintaining the same physical model (i.e. no iron model is necessary inside the equilibrium code). The successful implementation of this equilibrium code for JET and Tore Supra has already been published. In this paper, we show the preliminary results of predictive runs of the Equinox code using the ITER geometry. Because the real-time control experiments of plasma profile at JET using the code has been shown unstable when using magnetic and polarimetric measurements (that could be indirectly translated into accuracy vs robustness tradeoff), we plan an outline of the algorithm that will allow us to further constrain the plasma current profile using the central value of pressure of the plasma in real-time in order to better define the poloidal beta (this constraint is not necessary with purely magnetic equilibrium). (authors)

Route analysis for MHD equilibria

International Nuclear Information System (INIS)

Kikuchi, Fumio; Aizawa, Tatsuhiko

1982-01-01

In Tokamak facilities which are promising in nuclear fusion reactor development, the plasma in the core is often described by MHD approximation. Specifically, since an axisymmetric torus is approximately assumed as the first wall (shell) shape in actual Tokamak facilities, the Grad-Shafranov equation to be satisfied by an axisymmetric equilibrium solution for ideal MHD fluid must be solved, and the characteristics of its solution must be clarified. This paper shows the outline of the numerical calculation which employs both the incremental method taking the particular incremental nodal point values as the control parameters and the interaction method in accordance with Newton method at the same time, the analysis objective being a non-linear eigenvalue problem dealing the boundary of plasma region with surrounding vacuum region as the free boundary. Next, the detailed route analysis of the equilibrium solution is performed, utilizing the above numerical calculation technique, to clarify the effect of shell shape on the behaviour of the equilibrium solution. As the shape of the shell, a rectangular section torus, which have a notch depression at a part of the shell inner boundary, is considered. In the paper, the fundamental MHD equation and its approximate solution by the finite element method, the behaviour of plasma equilibrium solution in a shell having a notch, and the effect of notch shapes on plasma behaviour are described. This analysis verifies the effectiveness of the calculation method. (Wakatsuki, Y.)

Model for ICRF fast wave current drive in self-consistent MHD equilibria

International Nuclear Information System (INIS)

Bonoli, P.T.; Englade, R.C.; Porkolab, M.; Fenstermacher, M.E.

1993-01-01

Recently, a model for fast wave current drive in the ion cyclotron radio frequency (ICRF) range was incorporated into the current drive and MHD equilibrium code ACCOME. The ACCOME model combines a free boundary solution of the Grad Shafranov equation with the calculation of driven currents due to neutral beam injection, lower hybrid (LH) waves, bootstrap effects, and ICRF fast waves. The equilibrium and current drive packages iterate between each other to obtain an MHD equilibrium which is consistent with the profiles of driven current density. The ICRF current drive package combines a toroidal full-wave code (FISIC) with a parameterization of the current drive efficiency obtained from an adjoint solution of the Fokker Planck equation. The electron absorption calculation in the full-wave code properly accounts for the combined effects of electron Landau damping (ELD) and transit time magnetic pumping (TTMP), assuming a Maxwellian (or bi-Maxwellian) electron distribution function. Furthermore, the current drive efficiency includes the effects of particle trapping, momentum conserving corrections to the background Fokker Planck collision operator, and toroidally induced variations in the parallel wavenumbers of the injected ICRF waves. This model has been used to carry out detailed studies of advanced physics scenarios in the proposed Tokamak Physics Experiment (TPX). Results are shown, for example, which demonstrate the possibility of achieving stable equilibria at high beta and high bootstrap current fraction in TPX. Model results are also shown for the proposed ITER device

The rate of plasma heating by harmonic ion cyclotron waves in tokamaks

International Nuclear Information System (INIS)

Moslehi-Fard, M.; Sobhanian, S.; Solati-Kia, F.

2002-01-01

In tokamaks, the toroidal magnetic field, B φ , is due to the current in coils around plasma, and the poloidal magnetic field B p results from the plasma itself. Usually B φ p , and the combination of these two fields forms a nested set of toroidal magnetic surfaces. The equilibrium Grad-Shafranov equation is investigated and it is shown that the particle products of fusion with different pitch angles on these surfaces have different orbital shapes. In the JET tokamak, the α particles with pitch angle θ smaller than 54.8 deg are passing, those with θ between 54.8 deg and 65.1 deg have trapping-passing orbits but for θ greater than 65.1 deg the orbit has a banana form. Other tokamaks such as Alcator and ITER are also considered. The passing, trapping-passing and banana orbits in these tokamaks are traced. The results obtained from this calculation are analyzed. The wave damping has been investigated produced from interaction with particles, particularly α particles, and the rate of heating for l = 1 to 8 harmonics is plotted. The results of calculation show that heating at the fourth harmonic reaches a maximum. For higher harmonics, the heating does not change much from the fourth harmonic. (author)

Equilibrium reconstruction in the TCA/Br tokamak; Reconstrucao do equilibrio no tokamak TCA/BR

Energy Technology Data Exchange (ETDEWEB)

Sa, Wanderley Pires de

1996-12-31

The accurate and rapid determination of the Magnetohydrodynamic (MHD) equilibrium configuration in tokamaks is a subject for the magnetic confinement of the plasma. With the knowledge of characteristic plasma MHD equilibrium parameters it is possible to control the plasma position during its formation using feed-back techniques. It is also necessary an on-line analysis between successive discharges to program external parameters for the subsequent discharges. In this work it is investigated the MHD equilibrium configuration reconstruction of the TCA/BR tokamak from external magnetic measurements, using a method that is able to fast determine the main parameters of discharge. The thesis has two parts. Firstly it is presented the development of an equilibrium code that solves de Grad-Shafranov equation for the TCA/BR tokamak geometry. Secondly it is presented the MHD equilibrium reconstruction process from external magnetic field and flux measurements using the Function Parametrization FP method. this method. This method is based on the statistical analysis of a database of simulated equilibrium configurations, with the goal of obtaining a simple relationship between the parameters that characterize the equilibrium and the measurements. The results from FP are compared with conventional methods. (author) 68 refs., 31 figs., 16 tabs.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.

Science.gov (United States)

Warren, Travis K; Jordan, Robert; Lo, Michael K; Ray, Adrian S; Mackman, Richard L; Soloveva, Veronica; Siegel, Dustin; Perron, Michel; Bannister, Roy; Hui, Hon C; Larson, Nate; Strickley, Robert; Wells, Jay; Stuthman, Kelly S; Van Tongeren, Sean A; Garza, Nicole L; Donnelly, Ginger; Shurtleff, Amy C; Retterer, Cary J; Gharaibeh, Dima; Zamani, Rouzbeh; Kenny, Tara; Eaton, Brett P; Grimes, Elizabeth; Welch, Lisa S; Gomba, Laura; Wilhelmsen, Catherine L; Nichols, Donald K; Nuss, Jonathan E; Nagle, Elyse R; Kugelman, Jeffrey R; Palacios, Gustavo; Doerffler, Edward; Neville, Sean; Carra, Ernest; Clarke, Michael O; Zhang, Lijun; Lew, Willard; Ross, Bruce; Wang, Queenie; Chun, Kwon; Wolfe, Lydia; Babusis, Darius; Park, Yeojin; Stray, Kirsten M; Trancheva, Iva; Feng, Joy Y; Barauskas, Ona; Xu, Yili; Wong, Pamela; Braun, Molly R; Flint, Mike; McMullan, Laura K; Chen, Shan-Shan; Fearns, Rachel; Swaminathan, Swami; Mayers, Douglas L; Spiropoulou, Christina F; Lee, William A; Nichol, Stuart T; Cihlar, Tomas; Bavari, Sina

2016-03-17

The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents for treatment and prevention of acute Ebola virus (EBOV) disease (EVD) or sequelae. No antiviral therapeutics have yet received regulatory approval or demonstrated clinical efficacy. Here we report the discovery of a novel small molecule GS-5734, a monophosphoramidate prodrug of an adenosine analogue, with antiviral activity against EBOV. GS-5734 exhibits antiviral activity against multiple variants of EBOV and other filoviruses in cell-based assays. The pharmacologically active nucleoside triphosphate (NTP) is efficiently formed in multiple human cell types incubated with GS-5734 in vitro, and the NTP acts as an alternative substrate and RNA-chain terminator in primer-extension assays using a surrogate respiratory syncytial virus RNA polymerase. Intravenous administration of GS-5734 to nonhuman primates resulted in persistent NTP levels in peripheral blood mononuclear cells (half-life, 14 h) and distribution to sanctuary sites for viral replication including testes, eyes, and brain. In a rhesus monkey model of EVD, once-daily intravenous administration of 10 mg kg(-1) GS-5734 for 12 days resulted in profound suppression of EBOV replication and protected 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers, even when treatments were initiated three days after virus exposure when systemic viral RNA was detected in two out of six treated animals. These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates. The broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenaviruses, and coronaviruses, suggests the

Propiedades psicométricas del Maslach Burnout Inventory-GS en una muestra multiocupacional venezolana

Directory of Open Access Journals (Sweden)

Anthony Constant Millán de Lange

2012-06-01

Full Text Available Psychometric properties of the Maslach Burnout Inventory-GS in a Venezuelan sampleThe assessment of work stress is one of the most important aspects in the current scope of occupational psychological health, especially when it comes to chronic levels of involvement.Here are the results of the Venezuelan psychometric validation of the Cuban version of the Maslach Burnout Inventory-General Survey (MBI-GS. Results show adequate reliability of the instrument and suggest the need to remove item 1 to ensure its construct validity.Some indicators reveal the divergent criterion validity of the MBI-GS on the degree of the participant’s psychological well-being.

Overexpression of GsZFP1 enhances salt and drought tolerance in transgenic alfalfa (Medicago sativa L.).

Science.gov (United States)

Tang, Lili; Cai, Hua; Ji, Wei; Luo, Xiao; Wang, Zhenyu; Wu, Jing; Wang, Xuedong; Cui, Lin; Wang, Yang; Zhu, Yanming; Bai, Xi

2013-10-01

GsZFP1 encodes a Cys2/His2-type zinc-finger protein. In our previous study, when GsZFP1 was heterologously expressed in Arabidopsis, the transgenic Arabidopsis plants exhibited enhanced drought and cold tolerance. However, it is still unknown whether GsZFP1 is also involved in salt stress. GsZFP1 is from the wild legume Glycine soja. Therefore, the aims of this study were to further elucidate the functions of the GsZFP1 gene under salt and drought stress in the forage legume alfalfa and to investigate its biochemical and physiological functions under these stress conditions. Our data showed that overexpression of GsZFP1 in alfalfa resulted in enhanced salt tolerance. Under high salinity stress, greater relative membrane permeability and malondialdehyde (MDA) content were observed and more free proline and soluble sugars accumulated in transgenic alfalfa than in the wild-type (WT) plants; in addition, the transgenic lines accumulated less Na(+) and more K(+) in both the shoots and roots. Overexpression of GsZFP1 also enhanced the drought tolerance of alfalfa. The fold-inductions of stress-responsive marker gene expression, including MtCOR47, MtRAB18, MtP5CS, and MtRD2, were greater in transgenic alfalfa than those of WT under drought stress conditions. In conclusion, the transgenic alfalfa plants generated in this study could be used for farming in salt-affected as well as arid and semi-arid areas. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Behind the scenes of GS: an eye for accuracy

CERN Multimedia

Anaïs Schaeffer

2014-01-01

The CERN sites are constantly evolving… with new buildings, extensions, redevelopment and renovation. The team in charge of geographical information in the GS Department measures and records even the smallest changes so that it can provide everyone at CERN with the most up-to-date plans possible.   The “Patrimony” team in the GS-SE-DOP Section is responsible for geographical information and has the job of updating all of the information relating to CERN's property, including the land made available to the Organization by Switzerland (110 hectares) and France (516 hectares), green spaces, buildings, underground structures, underground networks (gas, water, electricity, etc. – for which the "Patrimony” team works closely with numerous other groups and departments), car parks, roads… and much more. “Our team consists of seven surveyors and GIS specialists, who identify, define, measure, catalogue and pinpoi...

Modeling of Eddy current distribution and equilibrium reconstruction in the SST-1 Tokamak

International Nuclear Information System (INIS)

Banerjee, Santanu; Sharma, Deepti; Radhakrishnana, Srinivasan; Daniel, Raju; Shankara Joisa, Y.; Atrey, Parveen Kumar; Pathak, Surya Kumar; Singh, Amit Kumar

2015-01-01

Toroidal continuity of the vacuum vessel and the cryostat leads to the generation of large eddy currents in these passive structures during the Ohmic phase of the steady state superconducting tokamak SST-1. This reduces the magnitude of the loop voltage seen by the plasma as also delays its buildup. During the ramping down of the Ohmic transformer current (OT), the resultant eddy currents flowing in the passive conductors play a crucial role in governing the plasma equilibrium. Amount of this eddy current and its distribution has to be accurately determined such that this can be fed to the equilibrium reconstruction code as an input. For the accurate inclusion of the effect of eddy currents in the reconstruction, the toroidally continuous conducting structures like the vacuum vessel and the cryostat with large poloidal cross-section and any other poloidal field (PF) coil sitting idle on the machine are broken up into a large number of co-axial toroidal current carrying filaments. The inductance matrix for this large set of toroidal current carrying conductors is calculated using the standard Green's function and the induced currents are evaluated for the OT waveform of each plasma discharge. Consistency of this filament model is cross-checked with the 11 in-vessel and 12 out-vessel toroidal flux loop signals in SST-1. Resistances of the filaments are adjusted to reproduce the experimental measurements of these flux loops in pure OT shots and shots with OT and vertical field (BV). Such shots are taken routinely in SST-1 without the fill gas to cross-check the consistency of the filament model. A Grad-Shafranov (GS) equation solver, named as IPREQ, has been developed in IPR to reconstruct the plasma equilibrium through searching for the best-fit current density profile. Ohmic transformer current (OT), vertical field coil current (BV), currents in the passive filaments along with the plasma pressure (p) and current (I p ) profiles are used as inputs to the IPREQ

Crystal structure of the β₂ adrenergic receptor-Gs protein complex

Energy Technology Data Exchange (ETDEWEB)

Rasmussen, Søren G.F.; DeVree, Brian T; Zou, Yaozhong; Kruse, Andrew C; Chung, Ka Young; Kobilka, Tong Sun; Thian, Foon Sun; Chae, Pil Seok; Pardon, Els; Calinski, Diane; Mathiesen, Jesper M; Shah, Syed T.A.; Lyons, Joseph A; Caffrey, Martin; Gellman, Samuel H; Steyaert, Jan; Skiniotis, Georgios; Weis, William I; Sunahara, Roger K; Kobilka, Brian K [Brussels; (Trinity); (Michigan); (Stanford-MED); (Michigan-Med); (UW)

2011-12-07

G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The paradigm of GPCR signalling is the activation of a heterotrimeric GTP binding protein (G protein) by an agonist-occupied receptor. The β₂ adrenergic receptor (β₂AR) activation of Gs, the stimulatory G protein for adenylyl cyclase, has long been a model system for GPCR signalling. Here we present the crystal structure of the active state ternary complex composed of agonist-occupied monomeric β₂AR and nucleotide-free Gs heterotrimer. The principal interactions between the β₂AR and Gs involve the amino- and carboxy-terminal α-helices of Gs, with conformational changes propagating to the nucleotide-binding pocket. The largest conformational changes in the β₂AR include a 14Å outward movement at the cytoplasmic end of transmembrane segment 6 (TM6) and an α-helical extension of the cytoplasmic end of TM5. The most surprising observation is a major displacement of the α-helical domain of Gαs relative to the Ras-like GTPase domain. This crystal structure represents the first high-resolution view of transmembrane signalling by a GPCR.

Behind the scenes of GS: preventing and curing

CERN Document Server

Anaïs Schaeffer

2014-01-01

With about 10,000 persons on the site every day, CERN’s infrastructure takes a real hammering every day of the year. Fortunately, the GS-SE Group is on the watch…   Here, like everywhere else, nothing stays shiny and new for very long. That’s why it’s important to carry out regular, even daily, maintenance of buildings, equipment, pipes and roads which every single day see thousands of CERN personnel and visitors passing by. The team responsible for this weighty task is part of the GS-SE Group. Suspicious steam All CERN’s buildings are heated by two heating plants (see the article in Bulletin 13-14/2011) via the underground hot-water network. Seen from below the ground, this is a labyrinth of pipes stretching over 30 km (including both the Meyrin and Prévessin sites). And with some of these pipes now over 40 years old, it goes without saying that leaks are a common hazard. “At the end of 2013, we had to deal with a big l...

The better growth phenotype of DvGS1-transgenic arabidopsis thaliana is attributed to the improved efficiency of nitrogen assimilation

Directory of Open Access Journals (Sweden)

Zhu Chenguang

2015-01-01

Full Text Available The overexpression of the algal glutamine synthetase (GS gene DvGS1 in Arabidopsis thaliana resulted in higher plant biomass and better growth phenotype. The purpose of this study was to recognize the biological mechanism for the growth improvement of DvGS1-transgenic Arabidopsis. A series of molecular and biochemical investigations related to nitrogen and carbon metabolism in the DvGS1-transgenic line was conducted. Analysis of nitrogen use efficiency (NUE-related gene transcription and enzymatic activity revealed that the transcriptional level and enzymatic activity of the genes encoding GS, glutamate synthase, glutamate dehydrogenase, alanine aminotransferase and aspartate aminotransferase, were significantly upregulated, especially from leaf tissues of the DvGS1-transgenic line under two nitrate conditions. The DvGS1-transgenic line showed increased total nitrogen content and decreased carbon: nitrogen ratio compared to wild-type plants. Significant reduced concentrations of free nitrate, ammonium, sucrose, glucose and starch, together with higher concentrations of total amino acids, individual amino acids (glutamate, aspartate, asparagine, methionine, soluble proteins and fructose in leaf tissues confirmed that the DvGS1-transgenic line demonstrated a higher efficiency of nitrogen assimilation, which subsequently affected carbon metabolism. These improved metabolisms of nitrogen and carbon conferred the DvGS1-transgenic Arabidopsis higher NUE, more biomass and better growth phenotype compared with the wild-type plants.

Behind the scenes of GS: the impact of IMPACT

CERN Multimedia

Katarina Anthony

2014-01-01

Carrying out a job at CERN can be a complicated task, with coordinators reaching across departments to manage personnel, ensure safety and minimise the impact of their activities on the rest of the Laboratory.  To help coordinators with this tough task, the GS Department developed IMPACT, the platform that, since 2011, has unified CERN's major experiment, accelerator and injector coordination tools.   When planning interventions both large and small, IMPACT (the Intervention Management Planning and Coordination Tool) is the go-to gizmo on every CERN coordinator's tool belt. "IMPACT is a central repository of activity requests that standardises the way work is declared at CERN," says Benoit Daudin, GS-AIS-PM Section Leader. "If you need to intervene in any of CERN's major facilities, you need to declare this work on IMPACT. The tool will analyse the job and see whose approval is required. This could simply b...

Investigation of structure and function of mitochondrial alcohol dehydrogenase isozyme III from Komagataella phaffii GS115.

Science.gov (United States)

Zhang, Huaidong; Li, Qin; Wang, Lina; Chen, Yan

2018-05-01

Alcohol dehydrogenases (ADHs) catalyze the reversible oxidation of alcohol using NAD + or NADP + as cofactor. Three ADH homologues have been identified in Komagataella phaffii GS115 (also named Pichia pastoris GS115), ADH1, ADH2 and ADH3, among which adh3 is the only gene responsible for consumption of ethanol in Komagataella phaffii GS115. However, the relationship between structure and function of mitochondrial alcohol dehydrogenase isozyme III from Komagataella phaffii GS115 (KpADH3) is still not clear yet. KpADH3 was purified, identified and characterized by multiple biophysical techniques (Nano LC-MS/MS, Enzymatic activity assay, X-ray crystallography). The crystal structure of KpADH3, which was the first ADH structure from Komagataella phaffii GS115, was solved at 1.745 Å resolution. Structural analysis indicated that KpADH3 was the sole dimeric ADH structure with face-to-face orientation quaternary structure from yeast. The major structural different conformations located on residues 100-114 (the structural zinc binding loop) and residues 337-344 (the loop between α12 and β15 which covered the catalytic domain). In addition, three channels were observed in KpADH3 crystal structure, channel 2 and channel 3 may be essential for substrate specific recognition, ingress and egress, channel 1 may be the pass-through for cofactor. KpADH3 plays an important role in the metabolism of alcohols in Komagataella phaffii GS115, and its crystal structure is the only dimeric medium-chain ADH from yeast described so far. Knowledge of the relationship between structure and function of KpADH3 is crucial for understanding the role of KpADH3 in Komagataella phaffii GS115 mitochondrial metabolism. Copyright © 2018 Elsevier B.V. All rights reserved.

A novel Fe(III) dependent bioflocculant from Klebsiella oxytoca GS-4-08: culture conditions optimization and flocculation mechanism.

Science.gov (United States)

Yu, Lei; Tang, Qing-Wen; Zhang, Yu-Jia; Chen, Rong-Ping; Liu, Xin; Qiao, Wei-Chuan; Li, Wen-Wei; Ruan, Hong-Hua; Song, Xin

2016-10-07

In this work, the effect of cultivation factors on the flocculation efficiency (FE) of bioflocculant P-GS408 from Klebsiella oxytoca was optimized by the response surface methodology. The most significant factor, i.e. culture time, was determined by gray relational analysis. A total of 240 mg of purified P-GS408 was prepared from 1 liter of culture solution under the optimal conditions. GC-MS analysis results indicated that the polysaccharide of P-GS408 mainly contains Rhamnose and Galactose, and the existence of abundant hydroxyl, carboxyl and amino groups was evidenced by FTIR and XPS analyses. With the aid of Fe 3+ , the FE of kaolin solution by P-GS408 could achieve 99.48% in ten minutes. Functional groups of polysaccharide were involved in the first adsorption step and the zeta potential of kaolin solution changed from -39.0 mV to 43.4 mV in the presence of Fe 3+ and P-GS408. Three-dimensional excitation-emission (EEM) fluorescence spectra demonstrates that the trivalent Fe 3+ and Al 3+ can bind efficiently with P-GS408, while those univalent and divalent cations cannot. With the help of SEM images, FTIR, zeta potential and EEM spectra, we proposed the P-GS408 flocculation mechanism, which consists of coordination bond combination, charge neutrality, adsorption and bridging, and net catching.

Behind the scenes of GS: each to his own lock and key

CERN Multimedia

Anaïs Schaeffer

2014-01-01

The GS-ASE team in charge of access control has an access solution for every type of premises, from radiation-controlled areas to simple administrative offices.   Although CERN is unquestionably open to the world, some of its doors must remain closed for a simple reason: as an industrial site, it must put safety and security at the top of its priorities and control access to certain areas in order to protect people and property from hazards. The AC (Access Control) section of the GS-ASE group uses a range of access control tools as the type of restrictions varies considerably according to the type of premises or area concerned: the requirements at the entrances to the different CERN sites may be quite different, for example, to those at the entrances to a specific building, a storage area, a workshop or an experiment hall within the fenced part of the CERN site. “We use different types of access systems at CERN”, explains Rui Nunes, head of the GS-ASE-AC section. &ldq...

Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase▿

Science.gov (United States)

Shih, I-hung; Vliegen, Inge; Peng, Betty; Yang, Huiling; Hebner, Christy; Paeshuyse, Jan; Pürstinger, Gerhard; Fenaux, Martijn; Tian, Yang; Mabery, Eric; Qi, Xiaoping; Bahador, Gina; Paulson, Matthew; Lehman, Laura S.; Bondy, Steven; Tse, Winston; Reiser, Hans; Lee, William A.; Schmitz, Uli; Neyts, Johan; Zhong, Weidong

2011-01-01

GS-9190 (Tegobuvir) is a novel imidazopyridine inhibitor of hepatitis C virus (HCV) RNA replication in vitro and has demonstrated potent antiviral activity in patients chronically infected with genotype 1 (GT1) HCV. GS-9190 exhibits reduced activity against GT2a (JFH1) subgenomic replicons and GT2a (J6/JFH1) infectious virus, suggesting that the compound's mechanism of action involves a genotype-specific viral component. To further investigate the GS-9190 mechanism of action, we utilized the susceptibility differences between GT1b and GT2a by constructing a series of replicon chimeras where combinations of 1b and 2a nonstructural proteins were encoded within the same replicon. The antiviral activities of GS-9190 against the chimeric replicons were reduced to levels comparable to that of the wild-type GT2a replicon in chimeras expressing GT2a NS5B. GT1b replicons in which the β-hairpin region (amino acids 435 to 455) was replaced by the corresponding sequence of GT2a were markedly less susceptible to GS-9190, indicating the importance of the thumb subdomain of the polymerase in this effect. Resistance selection in GT1b replicon cells identified several mutations in NS5B (C316Y, Y448H, Y452H, and C445F) that contributed to the drug resistance phenotype. Reintroduction of these mutations into wild-type replicons conferred resistance to GS-9190, with the number of NS5B mutations correlating with the degree of resistance. Analysis of GS-9190 cross-resistance against previously reported NS5B drug-selected mutations showed that the resistance pattern of GS-9190 is different from other nonnucleoside inhibitors. Collectively, these data demonstrate that GS-9190 represents a novel class of nonnucleoside polymerase inhibitors that interact with NS5B likely through involvement of the β-hairpin in the thumb subdomain. PMID:21746939

On Stable Wall Boundary Conditions for the Hermite Discretization of the Linearised Boltzmann Equation

Science.gov (United States)

Sarna, Neeraj; Torrilhon, Manuel

2018-01-01

We define certain criteria, using the characteristic decomposition of the boundary conditions and energy estimates, which a set of stable boundary conditions for a linear initial boundary value problem, involving a symmetric hyperbolic system, must satisfy. We first use these stability criteria to show the instability of the Maxwell boundary conditions proposed by Grad (Commun Pure Appl Math 2(4):331-407, 1949). We then recognise a special block structure of the moment equations which arises due to the recursion relations and the orthogonality of the Hermite polynomials; the block structure will help us in formulating stable boundary conditions for an arbitrary order Hermite discretization of the Boltzmann equation. The formulation of stable boundary conditions relies upon an Onsager matrix which will be constructed such that the newly proposed boundary conditions stay close to the Maxwell boundary conditions at least in the lower order moments.

RBiomirGS: an all-in-one miRNA gene set analysis solution featuring target mRNA mapping and expression profile integration

Directory of Open Access Journals (Sweden)

Jing Zhang

2018-01-01

Full Text Available Background With the continuous discovery of microRNA’s (miRNA association with a wide range of biological and cellular processes, expression profile-based functional characterization of such post-transcriptional regulation is crucial for revealing its significance behind particular phenotypes. Profound advancement in bioinformatics has been made to enable in depth investigation of miRNA’s role in regulating cellular and molecular events, resulting in a huge quantity of software packages covering different aspects of miRNA functional analysis. Therefore, an all-in-one software solution is in demand for a comprehensive yet highly efficient workflow. Here we present RBiomirGS, an R package for a miRNA gene set (GS analysis. Methods The package utilizes multiple databases for target mRNA mapping, estimates miRNA effect on the target mRNAs through miRNA expression profile and conducts a logistic regression-based GS enrichment. Additionally, human ortholog Entrez ID conversion functionality is included for target mRNAs. Results By incorporating all the core steps into one package, RBiomirGS eliminates the need for switching between different software packages. The modular structure of RBiomirGS enables various access points to the analysis, with which users can choose the most relevant functionalities for their workflow. Conclusions With RBiomirGS, users are able to assess the functional significance of the miRNA expression profile under the corresponding experimental condition by minimal input and intervention. Accordingly, RBiomirGS encompasses an all-in-one solution for miRNA GS analysis. RBiomirGS is available on GitHub (http://github.com/jzhangc/RBiomirGS. More information including instruction and examples can be found on website (http://kenstoreylab.com/?page_id=2865.

HARD X-RAY TAIL DISCOVERED IN THE CLOCKED BURSTER GS 1826–238

Energy Technology Data Exchange (ETDEWEB)

Rodi, J.; Jourdain, E.; Roques, J. P., E-mail: jrodi@irap.omp.eu [Université de Toulouse, UPS-OMP, IRAP, Toulouse (France)

2016-02-01

The low-mass X-ray binary (LMXB) neutron star (NS) GS 1826–238 was discovered by Ginga in 1988 September. Due to the presence of quasi-periodicity in the type I X-ray burst rate, the source has been a frequent target of X-ray observations for almost 30 years. Though the bursts were too soft to be detected by INTEGRAL/SPI, the persistent emission from GS 1826–238 was detected over 150 keV during the ∼10 years of observations. Spectral analysis found a significant high-energy excess above a Comptonization model that is well fit by a power law, indicating an additional spectral component. Most previously reported spectra with hard tails in LMXB NS have had an electron temperature of a few keV and a hard tail dominating above ∼50 keV with an index of Γ ∼ 2–3. GS 1826–238 was found to have a markedly different spectrum with kT{sub e} ∼ 20 keV and a hard tail dominating above ∼150 keV with an index of Γ ∼ 1.8, more similar to black hole X-ray binaries. We report on our search for long-term spectral variability over the 25–370 keV energy range and on a comparison of the GS 1826–238 average spectrum to the spectra of other LMXB NSs with hard tails.

MDM Redshift of the Host of ASASSN-17gs

Science.gov (United States)

Chornock, R.; Margutti, R.

2017-06-01

The optical transient ASASSN-17gs = AT2017egv (http://www.astronomy.ohio-state.edu/ assassin/transients.html, https://wis-tns.weizmann.ac.il/object/2017egv) was associated with the new Fermi LAT source J1544-0649 and a new, bright X-ray source Swift 154419.7-064915 by Ciprini et al. (ATel #10482).

Behind the scenes of GS: nothing left to chance

CERN Multimedia

Anaïs Schaeffer

2014-01-01

The AS (Alarm Systems) Section in the GS-ASE Group is, as its name suggests, in charge of the various alarm systems spread across CERN’s many sites. Its mission? To install, manage and maintain more than 26,000 alarms of all types located both above ground and in the tunnels.   Detection Among these systems, the best known are of course the heat and/or smoke detectors, which quickly raise the alarm in the event of a fire. CERN has 8500 of these devices in total. In combination with these, evacuation alarms are also found all over the Laboratory, including some 1800 break glass call points for 2000 sirens. In the LHC tunnel, the evacuation alarms are connected to 200 Oxygen Deficiency Hazard (ODH) sensors, but this is not the only way of triggering an alarm. “The Fire Brigade permanently monitors the evolution of safety conditions in the LHC tunnels,” says Henrik Nissen, who is responsible for “Alarm Transmission” in the GS-ASE-AS Section. &...

Conceptual design of plasma position control of SST-1 tokamak using vertical field coil

International Nuclear Information System (INIS)

Gulati, Hitesh Kumar; Patel, Kiritkumar B.; Dhongde, Jasraj

2015-01-01

SST-1 (Steady State Superconducting Tokamak) is a plasma confinement device in Institute for Plasma Research (IPR) India. SST-1 has been commissioned successfully and has been carrying out plasma experiments since the beginning of 2014 achieved a maximum plasma current of 75 kA at a central field of 1.5 T and the plasma duration ∼ 500 ms. SST-1 looks forward to carrying out elongated plasma experiments and stretching plasma pulses beyond 1s. Based on the solution of Grad-Shafranov equation the shift of plasma column center from geometrical centre of vacuum chamber is measured using various magnetic probes and flux loops installed in the machine. The closed feedback loop uses plasma current (Ip), Delta R as feedback signal and manipulate the vertical field current (Ivf). The discharge starts with feed forward loop using initially provided reference then the active feedback starts after discharge by few msec once plasma column is completely formed. The feedback loop time is of the order of 10 msec. The primary objective is to acquire plasma position control related signals, compute plasma position and generate position correction signal for VF coil power supply, communicate correction to VF coil power supply and modify VF power supply output in a deterministic time span. In this we present the methodology used for plasma horizontal displacement control using vertical field and discuss the preliminary results. (author)

Fast Waves Mode Conversion and Energy Deposition in Simulated, Pre-Heated, Neoclassical, Tight Aspect Ratio Tokamak Plasmas

International Nuclear Information System (INIS)

Bruma, C.; Cuperman, S.; Komoshvili, K.

1999-01-01

Some basic aspects of wave-plasma interaction of interest for tight aspect ratio spherical tokamaks are investigated theoretically. The following scenario is considered: A. Fast magnetosonic waves are launched by an external antenna into a simulated spherical Tokamak plasma; these waves are converted to Alfven waves at points (layer) satisfying the Alfven resonance condition. B. The simulated spherical tokamaks-plasma has a circular cross-section and toroidicity effects are simulated by Grad-Shafranov type, radially dependent axial magnetic field and its shear. (J. Actual equilibrium profiles (magnetic field, pressure and current) observed in the low field side (LFS) of spherical tokamaks (viz., START at Culham, UK) are used. D. The study is based on the numerical solution of the full e.m. wave equation which includes a quite general resistive MHD dielectric tensor, with consideration of equilibrium current and neoclassical effects. Two kinds of results will be presented: I. Proofs validating the computational algorithm used and including convergence and energy conservation. II. Exact quantitative results concerning (i) the structure and space dependence of the mode-converted Alfven waves and (ii) the basic features of the deposited p over . The dependence of the results on the launched wave characteristics (wave numbers, frequency and intensity) as well as on those of the equilibrium plasma (equilibrium current, neoclassical resistivity and electron inertia) will be discussed

ADI as a preconditioning for solving the convection-diffusion equation

International Nuclear Information System (INIS)

Chin, R.C.Y.; Manteuffel, T.A.; De Pillis, J.

1984-01-01

The authors examine a splitting of the operator obtained from a steady convection-diffusion equation with variable coefficients in which the convection term dominates. The operator is split into a dominant and subdominant parts consistent with the inherent directional property of the partial differential equation. The equations involving the dominant parts should be easily solved. The authors accelerate the convergence of this splitting or the outer iteration by a Chebyshev semi-iterative method. When the dominant part has constant coefficients, it can be easily solved using alternating direction implicit (ADI) methods. This is called the inner iteration. The optimal parameters for a stationary two-parameter ADI method are obtained when the eigenvalues become complex. This corresponds to either the horizontal or the vertical half-grid Reynolds number larger than unity. The Chebyshev semi-iterative method is used to accelerate the convergence of the inner ADI iteration. A two-fold increase in speed is obtained when the ADI iteration matrix has real eigenvalues, and the increase is less significant when the eigenvalues are complex. If either the horizontal or the vertical half-grid Reynolds number is equal to one, the spectral radius of the optimal ADI iterative matrix is zero. However, a high degree of nilpotency impairs rapid convergence. This problem is removed by introducing a more implicit iterative method called ADI/Gauss-Seidel (ADI/GS). ADI/GS resolves the nilpotency and, thus, converges more rapidly for half-grid Reynolds number near 1. Finally, these methods are compared with several well-known schemes on test problems. 23 references, 5 figures

Clenbuterol-Stimulated Glucose Uptake Activates both GS and GI ...

African Journals Online (AJOL)

β2-adrenoceptors activated by adrenaline can also couple to both Gs and Gi proteins. The former is associated with an increase in cAMP to illicit the effect of the catecholamine. In the later, β2-AR induces PKA-catalysed phosphorylation of the receptor, which intends couples to Gi, at high concentration. We proposed that ...

The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in decerebrate rats.

Science.gov (United States)

Copp, Steven W; Kim, Joyce S; Ruiz-Velasco, Victor; Kaufman, Marc P

2016-02-01

Mechanical and metabolic stimuli from contracting muscles evoke reflex increases in blood pressure, heart rate and sympathetic nerve activity. Little is known, however, about the nature of the mechano-gated channels on the thin fibre muscle afferents that contribute to evoke this reflex, termed the exercise pressor reflex. We determined the effect of GsMTx4, an inhibitor of mechano-gated Piezo channels, on the exercise pressor reflex evoked by intermittent contraction of the triceps surae muscles in decerebrated, unanaesthetized rats. GsMTx4 reduced the pressor, cardioaccelerator and renal sympathetic nerve responses to intermittent contraction but did not reduce the pressor responses to femoral arterial injection of compounds that stimulate the metabolically-sensitive thin fibre muscle afferents. Expression levels of Piezo2 channels were greater than Piezo1 channels in rat dorsal root ganglia. Our findings suggest that mechanically-sensitive Piezo proteins contribute to the generation of the mechanical component of the exercise pressor reflex in rats. Mechanical and metabolic stimuli within contracting skeletal muscles evoke reflex autonomic and cardiovascular adjustments. In cats and rats, gadolinium has been used to investigate the role played by the mechanical component of this reflex, termed the exercise pressor reflex. Gadolinium, however, has poor selectivity for mechano-gated channels and exerts multiple off-target effects. We tested the hypothesis that GsMTX4, a more selective mechano-gated channel inhibitor than gadolinium and a particularly potent inhibitor of mechano-gated Piezo channels, reduced the exercise pressor reflex in decerebrate rats. Injection of 10 μg of GsMTx4 into the arterial supply of the hindlimb reduced the peak pressor (control: 24 ± 5, GsMTx4: 12 ± 5 mmHg, P acid. Moreover, injection of 10 μg of GsMTx4 into the arterial supply of the hindlimb reduced the peak pressor (control: 24 ± 2, GsMTx4: 14 ± 3 mmHg, P reflex in

Improved method for reliable HMW-GS identification by RP-HPLC and SDS-PAGE in common wheat cultivars

Science.gov (United States)

The accurate identification of alleles for high-molecular weight glutenins (HMW-GS) is critical for wheat breeding programs targeting end-use quality. RP-HPLC methods were optimized for separation of HMW-GS, resulting in enhanced resolution of 1By and 1Dx subunits. Statistically significant differe...

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Science.gov (United States)

Nakajima, Ken-ichiro; Cui, Zhenzhong; Li, Chia; Meister, Jaroslawna; Cui, Yinghong; Fu, Ou; Smith, Adam S; Jain, Shalini; Lowell, Bradford B; Krashes, Michael J; Wess, Jürgen

2016-01-08

Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express various G protein-coupled receptors (GPCRs) with different coupling properties, including Gs-linked GPCRs. At present, the potential role of Gs-coupled GPCRs in regulating the activity of AgRP neurons remains unknown. Here we show that the activation of Gs-coupled receptors expressed by AgRP neurons leads to a robust and sustained increase in food intake. We also provide detailed mechanistic data linking the stimulation of this class of receptors to the observed feeding phenotype. Moreover, we show that this pathway is clearly distinct from other GPCR signalling cascades that are operative in AgRP neurons. Our data suggest that drugs able to inhibit this signalling pathway may become useful for the treatment of obesity.

Regulation of PDH, GS and insulin signalling in skeletal muscle

DEFF Research Database (Denmark)

Biensø, Rasmus Sjørup

of inflammation on resting and exercise-induced PDH regulation in human skeletal muscle and 4) The effect of IL-6 on PDH regulation in mouse skeletal muscle. Study I demonstrated that bed rest–induced insulin resistance was associated with reduced insulinstimulated GS activity and Akt signaling as well...

Swift observations of GS 1826-238

Science.gov (United States)

Ji, L.; Santangelo, A.; Zhang, S.; Ducci, L.; Suleimanov, V.

2018-02-01

GS 1826-238 is a well-studied low-mass X-ray binary neutron star. This source was in a persistent hard state since its discovery in 1988 and until 2014 June. After that, the source exhibited several softer periods of enhanced intensity in the energy range 2-20 keV. We studied the long-term light curves of MAXI (Monitor of All Sky X-ray Image) and Swift/BAT, and found clearly two branches in the MAXI-BAT and hardness-intensity diagrams, which correspond to the persistent state and softer periods, respectively. We analysed 21 Swift/XRT observations, of which four were located in the persistent state while the others were in softer periods or in a state between them. The XRT spectra could be generally fitted by using an absorbed Comptonization model with no other components required. We found a peculiar relationship between the luminosity and the hardness in the energy range of 0.6-10 keV: when the luminosity is larger (smaller) than 4 per cent-6 per cent Ledd, the hardness is anti-correlated (correlated) with luminosity. We also estimated the variability for each observation by using the fractional rms in the 0.1-10 Hz range. We found that the observations in the persistent state had a large fractional rms of ˜25 per cent, similar to other low-mass X-ray binaries. However, the variability is mainly found in the range of 5 per cent-20 per cent during softer periods. We suggest that GS 1826-238 did not evolve into the soft state of atoll sources, and all the observed XRT observations during the softer periods resemble a peculiar intermediate state of atoll sources.

Multicomponent fluid flow analysis using a new set of conservation equations

International Nuclear Information System (INIS)

Kamali, Reza; Emdad, Homayoon; Alishahi, Mohammad M

2008-01-01

In this work hydrodynamics of multicomponent ideal gas mixtures have been studied. Starting from the kinetic equations, the Eulerian approach is used to derive a new set of conservation equations for the multicomponent system where each component may have different velocity and kinetic temperature. The equations are based on the Grad's method of moment derived from the kinetic model in a relaxation time approximation (RTA). Based on this model which contains separate equation sets for each component of the system, a computer code has been developed for numerical computation of compressible flows of binary gas mixture in generalized curvilinear boundary conforming coordinates. Since these equations are similar to the Navier-Stokes equations for the single fluid systems, the same numerical methods are applied to these new equations. The Roe's numerical scheme is used to discretize the convective terms of governing fluid flow equations. The prepared algorithm and the computer code are capable of computing and presenting flow fields of each component of the system separately as well as the average flow field of the multicomponent gas system as a whole. Comparison of the present code results with those of a more common algorithm based on the mixture theory in a supersonic converging-diverging nozzle provides the validation of the present formulation. Afterwards, a more involved nozzle cooling problem with a binary ideal gas (helium-xenon) is chosen to compare the present results with those of the ordinary mixture theory. The present model provides the details of the flow fields of each component separately which is not available otherwise. It is also shown that the separate fluids treatment, such as the present study, is crucial when considering time scales on the order of (or shorter than) the intercollisions relaxation times.

Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species?

Directory of Open Access Journals (Sweden)

Oscar Franzén

2009-08-01

Full Text Available Giardia intestinalis is a major cause of diarrheal disease worldwide and two major Giardia genotypes, assemblages A and B, infect humans. The genome of assemblage A parasite WB was recently sequenced, and the structurally compact 11.7 Mbp genome contains simplified basic cellular machineries and metabolism. We here performed 454 sequencing to 16x coverage of the assemblage B isolate GS, the only Giardia isolate successfully used to experimentally infect animals and humans. The two genomes show 77% nucleotide and 78% amino-acid identity in protein coding regions. Comparative analysis identified 28 unique GS and 3 unique WB protein coding genes, and the variable surface protein (VSP repertoires of the two isolates are completely different. The promoters of several enzymes involved in the synthesis of the cyst-wall lack binding sites for encystation-specific transcription factors in GS. Several synteny-breaks were detected and verified. The tetraploid GS genome shows higher levels of overall allelic sequence polymorphism (0.5 versus <0.01% in WB. The genomic differences between WB and GS may explain some of the observed biological and clinical differences between the two isolates, and it suggests that assemblage A and B Giardia can be two different species.

Foam generation during G.S. [Girdler sulphide] process and its prevention

International Nuclear Information System (INIS)

Lammirato, Alberto; Rojo, Enrique.

1989-01-01

Available literature, from both foreign and local sources, regarding foam generation during Girdler Sulphide (G.S.) process operation, was compiled. Assembly and operation of a loop for hydraulic process conditions simulation, of which further tests are to be expected, is reported. (Author) [es

A review on the solution of Grad–Shafranov equation in the ...

Indian Academy of Sciences (India)

2017-02-10

Feb 10, 2017 ... coordinates based on the Chebyshev collocation technique. Z AMERIAN, M K SALEM, ... the power supply system. Any contact with ... often needed. Numerical .... Using composite differentiation (chain rule), and con- sidering ...

A high-yielding, generic fed-batch process for recombinant antibody production of GS-engineered cell lines

DEFF Research Database (Denmark)

Fan, Li; Zhao, Liang; Sun, Yating

2009-01-01

An animal component-free and chemically defined fed-batch process for GS-engineered cell lines producing recombinant antibodies has been developed. The fed-batch process relied on supplying sufficient nutrients to match their consumption, simultaneously minimizing the accumulation of byproducts....... This generic and high-yielding fed-batch process would shorten development time, and ensure process stability, thereby facilitating the manufacture of therapeutic antibodies by GS-engineered cell lines....

From Newton's Law to the Linear Boltzmann Equation Without Cut-Off

Science.gov (United States)

Ayi, Nathalie

2017-03-01

We provide a rigorous derivation of the linear Boltzmann equation without cut-off starting from a system of particles interacting via a potential with infinite range as the number of particles N goes to infinity under the Boltzmann-Grad scaling. More particularly, we will describe the motion of a tagged particle in a gas close to global equilibrium. The main difficulty in our context is that, due to the infinite range of the potential, a non-integrable singularity appears in the angular collision kernel, making no longer valid the single-use of Lanford's strategy. Our proof relies then on a combination of Lanford's strategy, of tools developed recently by Bodineau, Gallagher and Saint-Raymond to study the collision process, and of new duality arguments to study the additional terms associated with the long-range interaction, leading to some explicit weak estimates.

Base Input - Enrollment and Graduation Data for Naval Postgraduate School for the School of Business and Public Policy, Meyer Institute of Systems Engineering, and PhD Grads by curriculum by year.

OpenAIRE

2005-01-01

Graphs of Base Input - Enrollment and Graduation Data for Naval Postgraduate School for the School of Business and Public Policy, Meyer Institute of Systems Engineering, and PhD Grads by curriculum by year.

Molecular characterization of a novel algal glutamine synthetase (GS) and an algal glutamate synthase (GOGAT) from the colorful outer mantle of the giant clam, Tridacna squamosa, and the putative GS-GOGAT cycle in its symbiotic zooxanthellae.

Science.gov (United States)

Fam, Rachel R S; Hiong, Kum C; Choo, Celine Y L; Wong, Wai P; Chew, Shit F; Ip, Yuen K

2018-05-20

Giant clams harbor symbiotic zooxanthellae (Symbiodinium), which are nitrogen-deficient, mainly in the fleshy and colorful outer mantle. This study aimed to sequence and characterize the algal Glutamine Synthetase (GS) and Glutamate Synthase (GLT), which constitute the glutamate synthase cycle (or GS-GOGAT cycle, whereby GOGAT is the protein acronym of GLT) of nitrogen assimilation, from the outer mantle of the fluted giant clam, Tridacna squamosa. We had identified a novel GS-like cDNA coding sequence of 2325 bp, and named it as T. squamosa Symbiodinium GS1 (TSSGS1). The deduced TSSGS1 sequence had 774 amino acids with a molecular mass of 85 kDa, and displayed the characteristics of GS1 and Nucleotide Diphosphate Kinase. The cDNA coding sequence of the algal GLT, named as T. squamosa Symbiodinium GLT (TSSGLT), comprised 6399 bp, encoding a protein of 2133 amino acids and 232.4 kDa. The zooxanthellal origin of TSSGS1 and TSSGOGAT was confirmed by sequence comparison and phylogenetic analyses. Indeed, TSSGS1 and TSSGOGAT were expressed predominately in the outer mantle, which contained the majority of the zooxanthellae. Immunofluorescence microscopy confirmed the expression of TSSGS1 and TSSGOGAT in the cytoplasm and the plastids, respectively, of the zooxanthellae in the outer mantle. It can be concluded that the symbiotic zooxanthellae of T. squamosa possesses a glutamate synthase (TSSGS1-TSSGOGAT) cycle that can assimilate endogenous ammonia produced by the host clam into glutamate, which can act as a substrate for amino acid syntheses. Thus, our results provide insights into why intact giant clam-zooxanthellae associations do not excrete ammonia under normal circumstances. Copyright © 2018 Elsevier B.V. All rights reserved.

Synthesis and optimization of cholesterol-based diquaternary ammonium Gemini Surfactant (Chol-GS) as a new gene delivery vector.

Science.gov (United States)

Kim, Bieong-Kil; Doh, Kyung-Oh; Bae, Yun-Ui; Seu, Young-Bae

2011-01-01

Amongst a number of potential nonviral vectors, cationic liposomes have been actively researched, with both gemini surfactants and bola amphiphiles reported as being in possession of good structures in terms of cell viability and in vitro transfection. In this study, a cholesterol-based diquaternary ammonium gemini surfactant (Chol-GS) was synthesized and assessed as a novel nonviral gene vector. Chol-GS was synthesized from cholesterol by way of four reaction steps. The optimal efficiency was found to be at a weight ratio of 1:4 of lipid:DOPE (1,2-dioleoyl-L-alpha- glycero-3-phosphatidylethanolamine), and at a ratio of between 10:1~15:1 of liposome:DNA. The transfection efficiency was compared with commercial liposomes and with Lipofectamine, 1,2-dimyristyloxypropyl-3-dimethylhydroxyethylammonium bromide (DMRIE-C), and N-[1-(2,3-dioleoyloxy)propyl]- N,N,N-trimethylammonium chloride (DOTAP). The results indicate that the efficiency of Chol-GS is greater than that of all the tested commercial liposomes in COS7 and Huh7 cells, and higher than DOTAP and Lipofectamine in A549 cells. Confirmation of these findings was observed through the use of green fluorescent protein expression. Chol-GS exhibited a moderate level of cytotoxicity, at optimum concentrations for efficient transfection, indicating cell viability. Hence, the newly synthesized Chol-GS liposome has the potential of being an excellent nonviral vector for gene delivery.

Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology.

Science.gov (United States)

Suchyna, Thomas M

2017-11-01

Discovery of Piezo channels and the reporting of their sensitivity to the inhibitor GsMTx4 were important milestones in the study of non-selective cationic mechanosensitive channels (MSCs) in normal physiology and pathogenesis. GsMTx4 had been used for years to investigate the functional role of cationic MSCs, especially in muscle tissue, but with little understanding of its target or inhibitory mechanism. The sensitivity of Piezo channels to bilayer stress and its robust mechanosensitivity when expressed in heterologous systems were keys to determining GsMTx4's mechanism of action. However, questions remain regarding Piezo's role in muscle function due to the non-selective nature of GsMTx4 inhibition toward membrane mechanoenzymes and the implication of MCS channel types by genetic knockdown. Evidence supporting Piezo like activity, at least in the developmental stages of muscle, is presented. While the MSC targets of GsMTx4 in muscle pathology are unclear, its muscle protective effects are clearly demonstrated in two recent in situ studies on normal cardiomyocytes and dystrophic skeletal muscle. The muscle protective function may be due to the combined effect of GsMTx4's inhibitory action on cationic MSCs like Piezo and TRP, and its potentiation of repolarizing K + selective MSCs like K2P and SAKCa. Paradoxically, the potent in vitro action of GsMTx4 on many physiological functions seems to conflict with its lack of in situ side-effects on normal animal physiology. Future investigations into cytoskeletal control of sarcolemma mechanics and the suspected inclusion of MSCs in membrane micro/nano sized domains with distinct mechanical properties will aide our understanding of this dichotomy. Published by Elsevier Ltd.

Multiscale gyrokinetics for rotating tokamak plasmas: fluctuations, transport and energy flows.

Science.gov (United States)

Abel, I G; Plunk, G G; Wang, E; Barnes, M; Cowley, S C; Dorland, W; Schekochihin, A A

2013-11-01

This paper presents a complete theoretical framework for studying turbulence and transport in rapidly rotating tokamak plasmas. The fundamental scale separations present in plasma turbulence are codified as an asymptotic expansion in the ratio ε = ρi/α of the gyroradius to the equilibrium scale length. Proceeding order by order in this expansion, a set of coupled multiscale equations is developed. They describe an instantaneous equilibrium, the fluctuations driven by gradients in the equilibrium quantities, and the transport-timescale evolution of mean profiles of these quantities driven by the interplay between the equilibrium and the fluctuations. The equilibrium distribution functions are local Maxwellians with each flux surface rotating toroidally as a rigid body. The magnetic equilibrium is obtained from the generalized Grad-Shafranov equation for a rotating plasma, determining the magnetic flux function from the mean pressure and velocity profiles of the plasma. The slow (resistive-timescale) evolution of the magnetic field is given by an evolution equation for the safety factor q. Large-scale deviations of the distribution function from a Maxwellian are given by neoclassical theory. The fluctuations are determined by the 'high-flow' gyrokinetic equation, from which we derive the governing principle for gyrokinetic turbulence in tokamaks: the conservation and local (in space) cascade of the free energy of the fluctuations (i.e. there is no turbulence spreading). Transport equations for the evolution of the mean density, temperature and flow velocity profiles are derived. These transport equations show how the neoclassical and fluctuating corrections to the equilibrium Maxwellian act back upon the mean profiles through fluxes and heating. The energy and entropy conservation laws for the mean profiles are derived from the transport equations. Total energy, thermal, kinetic and magnetic, is conserved and there is no net turbulent heating. Entropy is produced

A Mutational Analysis of Residues in Cholera Toxin A1 Necessary for Interaction with Its Substrate, the Stimulatory G Protein Gsα

Directory of Open Access Journals (Sweden)

Michael G. Jobling

2015-03-01

Full Text Available Pathogenesis of cholera diarrhea requires cholera toxin (CT-mediated adenosine diphosphate (ADP-ribosylation of stimulatory G protein (Gsα in enterocytes. CT is an AB5 toxin with an inactive CTA1 domain linked via CTA2 to a pentameric receptor-binding B subunit. Allosterically activated CTA1 fragment in complex with NAD+ and GTP-bound ADP-ribosylation factor 6 (ARF6-GTP differs conformationally from the CTA1 domain in holotoxin. A surface-exposed knob and a short α-helix (formed, respectively, by rearranging “active-site” and “activation” loops in inactive CTA1 and an ADP ribosylating turn-turn (ARTT motif, all located near the CTA1 catalytic site, were evaluated for possible roles in recognizing Gsα. CT variants with one, two or three alanine substitutions at surface-exposed residues within these CTA1 motifs were tested for assembly into holotoxin and ADP-ribosylating activity against Gsα and diethylamino-(benzylidineamino-guanidine (DEABAG, a small substrate predicted to fit into the CTA1 active site. Variants with single alanine substitutions at H55, R67, L71, S78, or D109 had nearly wild-type activity with DEABAG but significantly decreased activity with Gsα, suggesting that the corresponding residues in native CTA1 participate in recognizing Gsα. As several variants with multiple substitutions at these positions retained partial activity against Gsα, other residues in CTA1 likely also participate in recognizing Gsα.

78 FR 10001 - Proposed Collection; Comment Request for Form 706-GS(D)

Science.gov (United States)

2013-02-12

... Form 706-GS(D), Generation-Skipping Transfer Tax Return for Distributions. DATES: Written comments should be received on or before April 15, 2013 to be assured of consideration. ADDRESSES: Direct all... [email protected] . SUPPLEMENTARY INFORMATION: Title: Generation-Skipping Transfer Tax Return for...

Fourth-order numerical solutions of diffusion equation by using SOR method with Crank-Nicolson approach

Science.gov (United States)

Muhiddin, F. A.; Sulaiman, J.

2017-09-01

The aim of this paper is to investigate the effectiveness of the Successive Over-Relaxation (SOR) iterative method by using the fourth-order Crank-Nicolson (CN) discretization scheme to derive a five-point Crank-Nicolson approximation equation in order to solve diffusion equation. From this approximation equation, clearly, it can be shown that corresponding system of five-point approximation equations can be generated and then solved iteratively. In order to access the performance results of the proposed iterative method with the fourth-order CN scheme, another point iterative method which is Gauss-Seidel (GS), also presented as a reference method. Finally the numerical results obtained from the use of the fourth-order CN discretization scheme, it can be pointed out that the SOR iterative method is superior in terms of number of iterations, execution time, and maximum absolute error.

Comparison between IAEA GS-R-3 and ISO 9001:2000

International Nuclear Information System (INIS)

Biscan, R.

2008-01-01

International Atomic Energy Agency (IAEA) developed Safety Standard 'The Management System for Facilities and Activities' (GS-R-3) to define the requirements for establishing, implementing, assessing, and continually improving an integrated management system to integrate: safety, health, environmental, security, quality and economic elements. Standard requirements must be met to ensure the protection of people and the environment and they are governed by the objectives, concepts and IAEA Safety Fundamentals principles. The GS-R-3 requirements may be used as the basis for the: Management System of organizations directly responsible for operating facilities and activities and providing services; Regulation of these facilities and activities by the regulatory body: Management System of the relevant regulatory bodies; Operator, to specify to the supplier, via contractual documentation, any specific requirements that must be included in the supplier's management system for the supply and delivery of products. International Organization for Standardization (ISO) developed International Standard 'Quality Management Systems - Requirements' (ISO 9001:2000) to specify requirements for a quality management system where an organization: Needs to demonstrate its ability to consistently provide product that meets customer and applicable regulatory requirements, and Aims to enhance customer satisfaction through the effective application of the system, including processes for continual improvement of the system and the assurance of conformity to customer and applicable regulatory requirements. IAEA GS-R-3 is focused on meeting the overall safety requirements for the plant, personnel and society in general, and grading the application of the management system. Any State wishing to enter into an agreement with the IAEA concerning any form of Agency assistance is required to comply with the requirements of this safety standard that pertain to the activities covered by the agreement

Control System Development Plan for the National Spherical Torus Experiment

International Nuclear Information System (INIS)

Neumeyer, C.; Mueller, D.; Gates, D.A.; Ferron, J.R.

1999-01-01

The National Spherical Torus Experiment (NSTX) has as one of its primary goals the demonstration of the attractiveness of the spherical torus concept as a fusion power plant. Central to this goal is the achievement of high plasma β ( = 2 micro 0 /B 2 a measure of the efficiency of a magnetic plasma confinement system). It has been demonstrated both theoretically and experimentally that the maximum achievable β is a strong function of both local and global plasma parameters. It is therefore important to optimize control of the plasma. To this end a phased development plan for digital plasma control on NSTX is presented. The relative level of sophistication of the control system software and hardware will be increased according to the demands of the experimental program in a three phase plan. During Day 0 (first plasma), a simple coil current control algorithm will initiate plasma operations. During the second phase (Day 1) of plasma operations the control system will continue to use the preprogrammed algorithm to initiate plasma breakdown but will then change over to a rudimentary plasma control scheme based on linear combinations of measured plasma fields and fluxes. The third phase of NSTX plasma control system development will utilize the rtEFIT code, first used on DIII-D, to determine, in real-time, the full plasma equilibrium by inverting the Grad-Shafranov equation. The details of the development plan, including a description of the proposed hardware will be presented

Behind the scenes of GS: a long-term urban planning vision

CERN Multimedia

Corinne Pralavorio

2014-01-01

The GS Department is working on a long-term plan for the urban planning of the CERN sites, ensuring that their development takes place using a coherent approach and keeping in mind the need for harmonious integration in the surrounding area.   Visitors are often bemused by CERN’s buildings, with their 1950s style and a layout that seems to defy all logic. Up until the 90s, buildings were erected as accelerators were built, with no apparent concern for harmony. But now, with a much larger number of users and installations, space is at a premium, getting around the site is difficult and urban planners are needed more than ever. "Over 9,000 people enter the CERN sites every day and we have 7,500 workstations," says Frédéric Magnin, Civil Engineering and Buildings Section Leader in the GS Department. For this reason, specialists in the department have been working on the development of the sites for five years. It is especially important that the...

Photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav and V345 Pav

Science.gov (United States)

Bruch, Albert

2017-10-01

As part of a project to better characterize comparatively bright, yet little studied cataclysmic variables time resolved photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav und V345 Pav is presented. Previously known orbital periods are significantly improved and long-term ephemeris are derived. Variations of eclipse profiles, occurring on time scales of days to weeks, are analyzed. Out of eclipse the light curves are characterized by low scale flickering superposed on more gradual variations with amplitudes limited to a few tenths of a magnitude and profiles which at least in EC 21178-5417 and GS Pav roughly follow the same pattern in all observed cycles. Additionally, signs for variations on the time scale of some tens of minutes are seen in GS Pav, most clearly in two subsequent nights when in the first of these a signal with a period of 15.7 min was observed over several hours. In the second night variations with twice this period were seen. While no additional insight could be gained on quasi periodic oscillations (QPOs) and dwarf nova oscillations in EC 21178-5417, previously detected by Warner et al. (2003), and while such oscillations could not be found in V345 Pav, stacked power spectra of GS Pav clearly reveal the presence of QPOs over time intervals of several hours with periods varying between 200 s and 500 s in that system.

Equilibrium measurements on the REPUTE-1 RFP plasma

International Nuclear Information System (INIS)

Ji, H.; Toyama, H.; Shinohara, S.; Fujisawa, A.; Yamagishi, K.; Shimazu, Y.; Ejiri, A.; Shimoji, K.; Miyamoto, K.

1989-01-01

Global plasma equilibrium measurements by external magnetic probes are widely introduced on the toroidal plasmas, i.e. tokamaks or RFPs, because of their simplicity and convenience. The measurement principle is based on Shafranov's toroidal equilibrium theory, which gives simple relations between the global equilibrium quantity and the external fields. These relations are valid in the either case of existence or absence of ideal shell just out the plasma column, however, not valid in the case of the thin (or resistive) shell, whose skin time τ s has the same order of the current rise time τ r . A method introduced by Swain et al. is effective in this case, in which the plasma current I p is replaced by 6 filament currents. However, by this method it is dificult to include the effect of iron core and computation requires a lot (beyond 14) of the measurement of the fields or flux loop. In this paper we introduce a simple method which is based on fitting measured fields to the vacuum approximate solution of Grad-Shafranov equation. The computation requires only a few measurements (≥6) of the fields. REPUTE-1 device is characterized by a thin shell of 5 mm thickness whose skin time τ s for the penetration of the vertical field is 1 ms compared with τ r of 0.5 ms. The optimum discharges whose duration τ d are about 3 times of τ s have been obtained. In spite of various efforts including vertical-ohmic coils series connection experiments, toroidal ripple reduction experiments and port bypass plate installation experiments, until now τ d is still limited by 3.2 ms. We should think that the equilibrium of plasma is lost due to an unfavorable vertical field. In this paper we present the measurements of the time evolution of the plasma position from the flat-top phase to the termination phase, at that time the plasma begins to lose its equilibrium. The liner has a major radius R L of 82 cm and a minor radius a L of 22 cm. (author) 6 refs., 4 figs

Use of plant trait data in the ISBA-A-gs model

Science.gov (United States)

Calvet, Jean-Christophe

2014-05-01

ISBA-A-gs is a CO2-responsive LSM (Calvet et al., 1998; Gibelin et al., 2006), able to simulate the diurnal cycle of carbon and water vapour fluxes, together with LAI and soil moisture evolution. The various components of ISBA-A-gs are based to a large extent on meta-analyses of trait data. (1) Photosynthesis: ISBA-A-gs uses the model of Goudriaan et al. (1985) modified by Jacobs (1994) and Jacobs et al. (1996). The main parameter is mesophyll conductance (gm). Leaf-level photosynthesis observations were used together with canopy level flux observations to derive gm together with other key parameters of the Jacobs model, including in drought conditions. This permitted implementing detailed representations of the soil moisture stress. Two different types of drought responses are distinguished for both herbaceous vegetation (Calvet, 2000) and forests (Calvet et al., 2004), depending on the evolution of the water use efficiency (WUE) under moderate stress: WUE increases in the early soil water stress stages in the case of the drought-avoiding response, whereas WUE decreases or remains stable in the case of the drought-tolerant response. (2) Plant growth: the leaf biomass is provided by a growth model (Calvet et al., 1998; Calvet and Soussana, 2001) driven by photosynthesis. In contrast to other land surface models, no GDD-based phenology model is used in ISBA-A-gs, as the vegetation growth and senescence are entirely driven by photosynthesis. The leaf biomass is supplied with the carbon assimilated by photosynthesis, and decreased by a turnover and a respiration term. Turnover is increased by a deficit in photosynthesis. The leaf onset is triggered by sufficient photosynthesis levels and a minimum LAI value is prescribed. The maximum annual value of LAI is prognostic, i.e. it can be predicted by the model. LAI is derived from leaf biomass using SLA values. The latter are derived from the leaf nitrogen concentration using plasticity parameters. (3) CO2 effect: the

5 CFR 531.217 - Special conversion rules for certain non-GS employees.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Special conversion rules for certain non... SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay Setting Pay When Appointment Or Position Changes § 531.217 Special conversion rules for certain non-GS employees. When an...

Potent Inhibitory Effects of D-tagatose on the Acid Production and Water-insoluble Glucan Synthesis of Streptococcus mutans GS5 in the Presence of Sucrose

OpenAIRE

Sawada, Daijo; Ogawa, Takaaki; Miyake, Minoru; Hasui, Yoshinori; Yamaguchi, Fuminori; Izumori, Ken; Tokuda, Masaaki

2015-01-01

We examined and compared the inhibitory effects of D-tagatose on the growth, acid production, and water-insoluble glucan synthesis of GS5, a bacterial strain of Streptococcus mutans, with those of xylitol, D-psicose, L-psicose and L-tagatose. GS5 was cultured for 12h in a medium containing 10ｵ (w/v) of xylitol, D-psicose, L-psicose, D-tagatose or L-tagatose, and the inhibitory effect of GS5 growth was assessed. Each sugar showed different inhibitory effects on GS5. Both D-tagatose and xylitol...

Analysis of glass from the post-Roman settlement Tonovcov grad (Slovenia) by PIXE–PIGE and LA-ICP-MS

Energy Technology Data Exchange (ETDEWEB)

Šmit, Ž., E-mail: ziga.smit@fmf.uni-lj.si [Faculty of Mathematics and Physics, University of Ljubljana, Jadranska 19, SI-1000 Ljubljana (Slovenia); Jožef Stefan Institute, Jamova 39, SI-1001 Ljubljana (Slovenia); Milavec, T. [Department of Archaeology, Faculty of Arts, University of Ljubljana, Zavetiška 5, SI-1000 Ljubljana (Slovenia); Fajfar, H. [Jožef Stefan Institute, Jamova 39, SI-1001 Ljubljana (Slovenia); Rehren, Th. [UCL Qatar, Education City, P.O. Box 23689, Doha (Qatar); Lankton, J.W. [UCL Institute of Archaeology, 31-34 Gordon Square, London WC1H 0PY (United Kingdom); Gratuze, B. [IRAMAT-Centre Ernest-Babelon, CNRS Université d’Orléans, 3D rue de la Ferollerie, 45071 Orléans Cedex 2 (France)

2013-09-15

The combined PIXE–PIGE method was used for the analysis of 43 glass fragments from the archaeological site Tonovcov grad in western Slovenia, with 10 of these additionally being analysed by LA-ICP-MS. The glass objects were attributed to the Late Antique production of the 4th–7th c. AD, with two examples of early Roman glass and three glass beads, one of them presumably of oriental origin. The analysis showed typical natron-type glass, produced in the Levantine region around the river Belus, and a few examples of HIMT glass, which could be recognized also in several other recycled objects. Only one glass bead, found in Early Medieval context, was made of the ash of halophytic plants.

Potent inhibitory effects of D-tagatose on the acid production and water-insoluble glucan synthesis of Streptococcus mutans GS5 in the presence of sucrose.

Science.gov (United States)

Sawada, Daijo; Ogawa, Takaaki; Miyake, Minoru; Hasui, Yoshinori; Yamaguchi, Fuminori; Izumori, Ken; Tokuda, Masaaki

2015-01-01

We examined and compared the inhibitory effects of D-tagatose on the growth, acid production, and water-insoluble glucan synthesis of GS5, a bacterial strain of Streptococcus mutans, with those of xylitol, D-psicose, L-psicose and L-tagatose. GS5 was cultured for 12h in a medium containing 10% (w/v) of xylitol, D-psicose, L-psicose, D-tagatose or L-tagatose, and the inhibitory effect of GS5 growth was assessed. Each sugar showed different inhibitory effects on GS5. Both D-tagatose and xylitol significantly inhibited the acid production and water-insoluble glucan synthesis of GS5 in the presence of 1% (w/v) sucrose. However, the inhibitory effect of acid production by D-tagatose was significantly stronger than that of xylitol in presence of sucrose.

GsLRPK, a novel cold-activated leucine-rich repeat receptor-like protein kinase from Glycine soja, is a positive regulator to cold stress tolerance.

Science.gov (United States)

Yang, Liang; Wu, Kangcheng; Gao, Peng; Liu, Xiaojuan; Li, Guangpu; Wu, Zujian

2014-02-01

Plant LRR-RLKs serve as protein interaction platforms, and as regulatory modules of protein activation. Here, we report the isolation of a novel plant-specific LRR-RLK from Glycine soja (termed GsLRPK) by differential screening. GsLRPK expression was cold-inducible and shows Ser/Thr protein kinase activity. Subcellular localization studies using GFP fusion protein indicated that GsLRPK is localized in the plasma membrane. Real-time PCR analysis indicated that temperature, salt, drought, and ABA treatment can alter GsLRPK gene transcription in G. soja. However, just protein induced by cold stress not by salinity and ABA treatment in tobacco was found to possess kinase activity. Furthermore, we found that overexpression of GsLRPK in yeast and Arabidopsis can enhance resistance to cold stress and increase the expression of a number of cold responsive gene markers. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

A numerical solution for a toroidal plasma in equilibrium

International Nuclear Information System (INIS)

Hintz, E.; Sudano, J.P.

1982-01-01

The iterative techniques alternating direction implicit (ADI), sucessive ove-relaxation (SOR) and Gauss-Seidel are applied to a nonlinear elliptical second order differential equation (Grand-Shafranov). This equation was solve with the free boundary conditions plasma-vacuum interface over a rectangular section in cylindrical coordinates R and Z. The current density profile, plasma pressure profile, magnetic and isobaric surfaces are numerically determined for a toroidal plasma in equilibrium. (L.C.) [pt

A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming.

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Alejandro Colaneri

Full Text Available Cell specific states of the chromatin are programmed during mammalian development. Dynamic DNA methylation across the developing embryo guides a program of repression, switching off genes in most cell types. Thus, the majority of the tissue specific differentially methylated sites (TS-DMS must be un-methylated CpGs.Comparison of expanded Methyl Sensitive Cut Counting data (eMSCC among four tissues (liver, testes, brain and kidney from three C57BL/6J mice, identified 138,052 differentially methylated sites of which 23,270 contain CpGs un-methylated in only one tissue (TS-DMS. Most of these CpGs were located in intergenic regions, outside of promoters, CpG islands or their shores, and up to 20% of them overlapped reported active enhancers. Indeed, tissue-specific enhancers were up to 30 fold enriched in TS-DMS. Testis showed the highest number of TS-DMS, but paradoxically their associated genes do not appear to be specific to the germ cell functions, but rather are involved in organism development. In the other tissues the differentially methylated genes are associated with tissue-specific physiological or anatomical functions. The identified sets of TS-DMS quantify epigenetic distances between tissues, generated during development. We applied this concept to measure the extent of reprogramming in the liver of mice exposed to in utero or early postnatal nutritional stress. Different protocols of food restriction reprogrammed the liver methylome in different but reproducible ways.Thus, each identified set of differentially methylated sites constituted an epigenetic signature that traced the developmental programing or the early nutritional reprogramming of each exposed mouse. We propose that our approach has the potential to outline a number of disease-associated epigenetic states. The composition of differentially methylated CpGs may vary with each situation, behaving as a composite variable, which can be used as a pre-symptomatic marker for

Analysis of the Second Law of Thermodynamics applied to GS process in the primary production of heavy water

International Nuclear Information System (INIS)

Chavez, Rosa Hilda

1991-01-01

An evaluation of the entropic change, through the analysis of the Second Law of Thermodynamic of GS process, with the aim of determine the sections where the majors irreversibilities of the process are located, is presented in this work. This process consist in the first enrichment stage of GS, which operates bithermally at 305 D and 403 Kelvin degree and a pressure of 2 MPa, participating four chemical compounds: H 2 O, HDO, H 2 S and HDS (Author)

Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs.

Directory of Open Access Journals (Sweden)

Olivier Reynard

Full Text Available Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever. IgG glycans display powerful xenogeneic antigens in humans, for example α1-3 Galactose and the glycolyl form of neuraminic acid Neu5Gc, and IgGs deprived of these key sugar epitopes may represent an advantage for passive immunotherapy. In this paper, we explored whether low immunogenicity IgGs had a protective effect on a guinea pig model of Ebola virus (EBOV infection. For this purpose, a double knock-out pig lacking α1-3 Galactose and Neu5Gc was immunized against virus-like particles displaying surface EBOV glycoprotein GP. Following purification from serum, hyper-immune polyclonal IgGs were obtained, exhibiting an anti-EBOV GP titer of 1:100,000 and a virus neutralizing titer of 1:100. Guinea pigs were injected intramuscularly with purified IgGs on day 0 and day 3 post-EBOV infection. Compared to control animals treated with IgGs from non-immunized double KO pigs, the anti-EBOV IgGs-treated animals exhibited a significantly prolonged survival and a decreased virus load in blood on day 3. The data obtained indicated that IgGs lacking α1-3 Galactose and Neu5Gc, two highly immunogenic epitopes in humans, have a protective effect upon EBOV infection.

Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs

Science.gov (United States)

Reynard, Olivier; Jacquot, Frédéric; Evanno, Gwénaëlle; Mai, Hoa Le; Martinet, Bernard; Duvaux, Odile; Bach, Jean-Marie; Conchon, Sophie; Judor, Jean-Paul; Perota, Andrea; Lagutina, Irina; Duchi, Roberto; Lazzari, Giovanna; Le Berre, Ludmilla; Perreault, Hélène; Lheriteau, Elsa; Raoul, Hervé; Volchkov, Viktor; Galli, Cesare; Soulillou, Jean-Paul

2016-01-01

Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever. IgG glycans display powerful xenogeneic antigens in humans, for example α1–3 Galactose and the glycolyl form of neuraminic acid Neu5Gc, and IgGs deprived of these key sugar epitopes may represent an advantage for passive immunotherapy. In this paper, we explored whether low immunogenicity IgGs had a protective effect on a guinea pig model of Ebola virus (EBOV) infection. For this purpose, a double knock-out pig lacking α1–3 Galactose and Neu5Gc was immunized against virus-like particles displaying surface EBOV glycoprotein GP. Following purification from serum, hyper-immune polyclonal IgGs were obtained, exhibiting an anti-EBOV GP titer of 1:100,000 and a virus neutralizing titer of 1:100. Guinea pigs were injected intramuscularly with purified IgGs on day 0 and day 3 post-EBOV infection. Compared to control animals treated with IgGs from non-immunized double KO pigs, the anti-EBOV IgGs-treated animals exhibited a significantly prolonged survival and a decreased virus load in blood on day 3. The data obtained indicated that IgGs lacking α1–3 Galactose and Neu5Gc, two highly immunogenic epitopes in humans, have a protective effect upon EBOV infection. PMID:27280712

Implementation of a management system in accordance with IAEA GS-R-3 Standard. A gap analysis

International Nuclear Information System (INIS)

Dicianu, I.; Oprea, M.

2009-01-01

Full text: The design and implementation of an Integrated Management System at SNN SA Headquarters become necessary as the CNCAN norms are already under revision to comply with the IAEA GS-R-3 standard. The purpose of this analysis is to draft a project for the transition from a Quality Management System (QMS) to an Integrated Management System (IMS) complying with GS-R-3 requirements. Four steps were identified for developing this project: STEP1 - To justify the necessity of the IMS implementation to meet the SNN SA Headquarters Top Management commitments. The requirements for implementing an IMS are analyzed and a comprehensive document is issued to (and maybe discussed with) SNN General Director in order to obtain the top management adherence/commitment to the project implementation. The document will show the strong and the weak points which should be considered in developing the project. The references for the project are: - IAEA Safety Standard GS-R-3 'The Management System for Facilities and Activities'; - ISO - 1400/2004 Standard 'Environmental Management System Requirements'; - OHSAS 18001/2007 Standard 'Occupational Health and Safety Management Systems. Requirements'; There are also considered: - IAEA Safety Guide GS-G-3.1 'Application of the Management System for Facilities and Activities'; - IAEA Draft Safety Guide DS-349 'Application of the Management System for Nuclear Facilities; There will be considered: Workshop 2 Bookmarks (F5) 2 - CNCAN Norms (as they will be revised); STEP2 - The performance of a comparative analysis of the requirements of GS-R-3, ISO 14001 and OHSAS 18001 versus the provisions of the QMS already implemented in SNN. This analysis is shown as a comparative table; STEP3 - Identification of the IMS processes. An overall analysis of the current processes described in the SNN QMS Manual is performed and based on this. There are identified the additional processes that have to be documented for the proper implementation of an IMS

The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in rats with ligated femoral arteries.

Science.gov (United States)

Copp, Steven W; Kim, Joyce S; Ruiz-Velasco, Victor; Kaufman, Marc P

2016-05-01

Mechanical and metabolic stimuli arising from contracting muscles evoke the exercise pressor reflex. This reflex is greater in a rat model of simulated peripheral arterial disease in which a femoral artery is chronically ligated than it is in rats with freely perfused femoral arteries. The role played by the mechanically sensitive component of the exaggerated exercise pressor reflex in ligated rats is unknown. We tested the hypothesis that the mechano-gated channel inhibitor GsMTx4, a relatively selective inhibitor of mechano-gated Piezo channels, reduces the exercise pressor reflex in decerebrate rats with ligated femoral arteries. Injection of 10 μg of GsMTx4 into the arterial supply of the hindlimb reduced the pressor response to Achilles tendon stretch (a purely mechanical stimulus) but had no effect on the pressor responses to intra-arterial injection of α,β-methylene ATP or lactic acid (purely metabolic stimuli). Moreover, injection of 10 μg of GsMTx4 into the arterial supply of the hindlimb reduced both the integrated pressor area (control 535 ± 21, GsMTx4 218 ± 24 mmHg·s; P reflex contributes to the exaggerated exercise pressor reflex during intermittent hindlimb muscle contractions in rats with ligated femoral arteries. Copyright © 2016 the American Physiological Society.

Glutathione preservation during storage of rat lenses in optisol-GS and castor oil.

Science.gov (United States)

Holm, Thomas; Brøgger-Jensen, Martin Rocho; Johnson, Leif; Kessel, Line

2013-01-01

Glutathione concentration in the lens decreases in aging and cataractous lenses, providing a marker for tissue condition. Experimental procedures requiring unfrozen lenses from donor banks rely on transportation in storage medium, affecting lens homeostasis and alterations in glutathione levels. The aim of the study was to examine the effects of Optisol-GS and castor oil on lens condition, determined from their ability to maintain glutathione concentrations. Rat lenses were stored in the two types of storage media at varying time intervals up to 3 days. Glutathione concentration was afterwards determined in an enzymatic detection assay, specific for both reduced and oxidized forms. Lenses removed immediately after death exhibited a glutathione concentration of 4.70±0.29 mM. In vitro stored lenses in Optisol-GS lost glutathione quickly, ending with a concentration of 0.60±0.34 mM after 3 days while castor oil stored lenses exhibited a slower decline and ended at 3 times the concentration. A group of lenses were additionally stored under post mortem conditions within the host for 6 hours before its removal. Total glutathione after 6 hours was similar to that of lenses removed immediately after death, but with altered GSH and GSSG concentrations. Subsequent storage of these lenses in media showed changes similar to those in the first series of experiments, albeit to a lesser degree. It was determined that storage in Optisol-GS resulted in a higher loss of glutathione than lenses stored in castor oil. Storage for more than 12 hours reduced glutathione to half its original concentration, and was considered unusable after 24 hours.

Glutathione preservation during storage of rat lenses in optisol-GS and castor oil.

Directory of Open Access Journals (Sweden)

Thomas Holm

Full Text Available BACKGROUND: Glutathione concentration in the lens decreases in aging and cataractous lenses, providing a marker for tissue condition. Experimental procedures requiring unfrozen lenses from donor banks rely on transportation in storage medium, affecting lens homeostasis and alterations in glutathione levels. The aim of the study was to examine the effects of Optisol-GS and castor oil on lens condition, determined from their ability to maintain glutathione concentrations. METHODOLOGY/PRINCIPAL FINDINGS: Rat lenses were stored in the two types of storage media at varying time intervals up to 3 days. Glutathione concentration was afterwards determined in an enzymatic detection assay, specific for both reduced and oxidized forms. Lenses removed immediately after death exhibited a glutathione concentration of 4.70±0.29 mM. In vitro stored lenses in Optisol-GS lost glutathione quickly, ending with a concentration of 0.60±0.34 mM after 3 days while castor oil stored lenses exhibited a slower decline and ended at 3 times the concentration. A group of lenses were additionally stored under post mortem conditions within the host for 6 hours before its removal. Total glutathione after 6 hours was similar to that of lenses removed immediately after death, but with altered GSH and GSSG concentrations. Subsequent storage of these lenses in media showed changes similar to those in the first series of experiments, albeit to a lesser degree. CONCLUSIONS/SIGNIFICANCE: It was determined that storage in Optisol-GS resulted in a higher loss of glutathione than lenses stored in castor oil. Storage for more than 12 hours reduced glutathione to half its original concentration, and was considered unusable after 24 hours.

Proteolytic activity of IgGs from blood serum of wistar rats at experimental rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Yu. Ya. Kit

2014-10-01

Full Text Available The aim of this work was to study the proteolytic activity of IgGs purified from blood serum of Wistar rats at experimental rheumatoid arthritis (ERA induced by an injection of bovine collagen of type II. Twenty rats were immunized with a preparation of bovine collagen II (Sigma-Aldrich, USA in the presence of complete Freund’s adjuvant. ERA development was determined by inflammation in limbs of treated animals. IgG preparations were isolated from blood serum of immunized and non-immunized animals by precipitation of antibodies with 33% ammonium sulfate followed by chromatography on the Protein G-Sepharose column. Human histone H1, bovine collagen II, calf thymus histones, myelin basic protein (MBP, bovine serum albumin (BSA, and bovine casein were used as substrates of the proteolytic activity of IgGs. It was found that IgG preparations from blood serum of rats with ERA were capable of cleaving histone H1 and MBP, however, they were catalytically inactive towards collagen II, casein, BSA, and core histones. IgGs from blood serum of non-immunized rats were proteolytically inactive towards all used protein substrates. Thus, we demonstrated that immunization of rats with bovine collagen II induced IgG-antibodies possessing the proteolytic activity towards histone H1 and MBP. This activity might be associated with the development of inflammatory processes in the immunized rats.

INTERACCIÓN DE LA GLUTAMINA SINTETASA (GS Y EL PÉPTIDO β -AMILOIDE COMO UNA ESTRATEGIA DE PURIFICACIÓN

Directory of Open Access Journals (Sweden)

Sonia Luz Albarracín

2013-08-01

Full Text Available La enfermedad de Alzheimer (EA esla forma de demencia más común en laedad adulta. Se manifiesta con la pérdidaprogresiva de la memoria a medida quelas neuronas en la corteza cerebral y elhipocampo mueren. En todas las formasde EA se evidencia aumento de la expresiónde diferentes proteínas, así comola presencia de agregados insolubles depéptido-β-amiloide (PBA. La glutaminasintetasa (GS es una enzima clave en elmetabolismo del glutamato y en la detoxificaciónde amonio (NH4+. Previamentese ha reportado una posible interacciónGS-PBA que puede estar asociada conEA. En este trabajo se realizó la purificaciónde la enzima cerebral de rata a partirde un extracto sometido a precipitaciónfraccionada con (NH42SO4 del 20-60 %de saturación y posteriormente a travésde cromatografías sucesivas de filtraciónen gel, intercambio iónico y afinidad. Elpeso molecular del complejo fue calculadoen 137 kDa por el orden de eluciónen la columna de filtración. Se identificóinteracción de la enzima con PBA1-40, lográndose la purificación de unasola banda de 45 kDa, correspondiente ala forma monomérica de la GS. En estetrabajo se presenta un nuevo método depurificación de la enzima y se demuestrala interacción de GS con el PBA. Se proponeque esta interacción GS-PBA puedeser uno de los procesos que se presentanen la enfermedad al explicar la reducciónde la actividad de la enzima en pacientes con EA, ya que podría alterar el cicloglutamato-glutamina y generar cambiosen el entorno celular que favorecen excitotoxicidadpor glutamato típica de losprocesos de neurodegeneración.

Comparisons of 'Identical' Simulations by the Eulerian Gyrokinetic Codes GS2 and GYRO

Science.gov (United States)

Bravenec, R. V.; Ross, D. W.; Candy, J.; Dorland, W.; McKee, G. R.

2003-10-01

A major goal of the fusion program is to be able to predict tokamak transport from first-principles theory. To this end, the Eulerian gyrokinetic code GS2 was developed years ago and continues to be improved [1]. Recently, the Eulerian code GYRO was developed [2]. These codes are not subject to the statistical noise inherent to particle-in-cell (PIC) codes, and have been very successful in treating electromagnetic fluctuations. GS2 is fully spectral in the radial coordinate while GYRO uses finite-differences and ``banded" spectral schemes. To gain confidence in nonlinear simulations of experiment with these codes, ``apples-to-apples" comparisons (identical profile inputs, flux-tube geometry, two species, etc.) are first performed. We report on a series of linear and nonlinear comparisons (with overall agreement) including kinetic electrons, collisions, and shaped flux surfaces. We also compare nonlinear simulations of a DIII-D discharge to measurements of not only the fluxes but also the turbulence parameters. [1] F. Jenko, et al., Phys. Plasmas 7, 1904 (2000) and refs. therein. [2] J. Candy, J. Comput. Phys. 186, 545 (2003).

HMW-GS affect the properties of glutenin particles in GMP and thus flour quality

NARCIS (Netherlands)

Don, C.; Mann, G.; Bekes, F.; Hamer, R.J.

2006-01-01

Using a unique set of deletion lines, (Olympic×Gabo, varying in high molecular weight glutenin subunit (HMW-GS) composition, but with the same genetic background) it was shown that the presence of glutenin particles in glutenin macropolymer (GMP) is directly related to the presence of certain

A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors

DEFF Research Database (Denmark)

Vedel, Line; Bräuner-Osborne, Hans; Mathiesen, Jesper Mosolff

2015-01-01

Cyclic adenosine 3',5'-monophosphate (cAMP) is an important second messenger, and quantification of intracellular cAMP levels is essential in studies of G protein-coupled receptors (GPCRs). The intracellular cAMP levels are regulated by the adenylate cyclase (AC) upon activation of either Gs- or ...... also observed for the other representative Gs-coupled GPCRs tested, GLP-1R and GlucagonR. The FRET-based cAMP biosensor assay is robust, reproducible, and inexpensive with good Z factors and is highly applicable for HTS....

Necessary and sufficient liveness condition of GS3PR Petri nets

Science.gov (United States)

Liu, GaiYun; Barkaoui, Kamel

2015-05-01

Structural analysis is one of the most important and efficient methods to investigate the behaviour of Petri nets. Liveness is a significant behavioural property of Petri nets. Siphons, as structural objects of a Petri net, are closely related to its liveness. Many deadlock control policies for flexible manufacturing systems (FMS) modelled by Petri nets are implemented via siphon control. Most of the existing methods design liveness-enforcing supervisors by adding control places for siphons based on their controllability conditions. To compute a liveness-enforcing supervisor with as much as permissive behaviour, it is both theoretically and practically significant to find an exact controllability condition for siphons. However, the existing conditions, max, max‧, and max″-controllability of siphons are all overly restrictive and generally sufficient only. This paper develops a new condition called max*-controllability of the siphons in generalised systems of simple sequential processes with resources (GS3PR), which are a net subclass that can model many real-world automated manufacturing systems. We show that a GS3PR is live if all its strict minimal siphons (SMS) are max*-controlled. Compared with the existing conditions, i.e., max-, max‧-, and max″-controllability of siphons, max*-controllability of the SMS is not only sufficient but also necessary. An example is used to illustrate the proposed method.

Quantitative Pointwise Estimate of the Solution of the Linearized Boltzmann Equation

Science.gov (United States)

Lin, Yu-Chu; Wang, Haitao; Wu, Kung-Chien

2018-04-01

We study the quantitative pointwise behavior of the solutions of the linearized Boltzmann equation for hard potentials, Maxwellian molecules and soft potentials, with Grad's angular cutoff assumption. More precisely, for solutions inside the finite Mach number region (time like region), we obtain the pointwise fluid structure for hard potentials and Maxwellian molecules, and optimal time decay in the fluid part and sub-exponential time decay in the non-fluid part for soft potentials. For solutions outside the finite Mach number region (space like region), we obtain sub-exponential decay in the space variable. The singular wave estimate, regularization estimate and refined weighted energy estimate play important roles in this paper. Our results extend the classical results of Liu and Yu (Commun Pure Appl Math 57:1543-1608, 2004), (Bull Inst Math Acad Sin 1:1-78, 2006), (Bull Inst Math Acad Sin 6:151-243, 2011) and Lee et al. (Commun Math Phys 269:17-37, 2007) to hard and soft potentials by imposing suitable exponential velocity weight on the initial condition.

Quantitative Pointwise Estimate of the Solution of the Linearized Boltzmann Equation

Science.gov (United States)

Lin, Yu-Chu; Wang, Haitao; Wu, Kung-Chien

2018-06-01

We study the quantitative pointwise behavior of the solutions of the linearized Boltzmann equation for hard potentials, Maxwellian molecules and soft potentials, with Grad's angular cutoff assumption. More precisely, for solutions inside the finite Mach number region (time like region), we obtain the pointwise fluid structure for hard potentials and Maxwellian molecules, and optimal time decay in the fluid part and sub-exponential time decay in the non-fluid part for soft potentials. For solutions outside the finite Mach number region (space like region), we obtain sub-exponential decay in the space variable. The singular wave estimate, regularization estimate and refined weighted energy estimate play important roles in this paper. Our results extend the classical results of Liu and Yu (Commun Pure Appl Math 57:1543-1608, 2004), (Bull Inst Math Acad Sin 1:1-78, 2006), (Bull Inst Math Acad Sin 6:151-243, 2011) and Lee et al. (Commun Math Phys 269:17-37, 2007) to hard and soft potentials by imposing suitable exponential velocity weight on the initial condition.

Ground Source Integrated Heat Pump (GS-IHP) Development

Energy Technology Data Exchange (ETDEWEB)

Baxter, V. D. [ORNL; Rice, K. [ORNL; Murphy, R. [ORNL; Munk, J. [ORNL; Ally, Moonis [ORNL; Shen, Bo [ORNL; Craddick, William [ORNL; Hearn, Shawn A. [ClimateMaster, Inc.

2013-05-24

Between October 2008 and May 2013 ORNL and ClimateMaster, Inc. (CM) engaged in a Cooperative Research and Development Agreement (CRADA) to develop a groundsource integrated heat pump (GS-IHP) system for the US residential market. A initial prototype was designed and fabricated, lab-tested, and modeled in TRNSYS (SOLAR Energy Laboratory, et al, 2010) to predict annual performance relative to 1) a baseline suite of equipment meeting minimum efficiency standards in effect in 2006 (combination of air-source heat pump (ASHP) and resistance water heater) and 2) a state-of-the-art (SOA) two-capacity ground-source heat pump with desuperheater water heater (WH) option (GSHPwDS). Predicted total annual energy savings, while providing space conditioning and water heating for a 2600 ft{sup 2} (242 m{sup 2}) house at 5 U.S. locations, ranged from 52 to 59%, averaging 55%, relative to the minimum efficiency suite. Predicted energy use for water heating was reduced 68 to 78% relative to resistance WH. Predicted total annual savings for the GSHPwDS relative to the same baseline averaged 22.6% with water heating energy use reduced by 10 to 30% from desuperheater contributions. The 1st generation (or alpha) prototype design for the GS-IHP was finalized in 2010 and field test samples were fabricated for testing by CM and by ORNL. Two of the alpha units were installed in 3700 ft{sup 2} (345 m{sup 2}) houses at the ZEBRAlliance site in Oak Ridge and field tested during 2011. Based on the steady-state performance demonstrated by the GS-IHPs it was projected that it would achieve >52% energy savings relative to the minimum efficiency suite at this specific site. A number of operational issues with the alpha units were identified indicating design changes needed to the system before market introduction could be accomplished. These were communicated to CM throughout the field test period. Based on the alpha unit test results and the diagnostic information coming from the field test

A 12b 2.9GS/s DAC with IM3>60dB beyond 1 GHz in 65nm CMOS

NARCIS (Netherlands)

Lin, C.H.; Goes, F.; Westra, J.; Mulder, J.; Lin, Y.; Arslan, E.; Ayranci, E.; Liu, X.; Bult, K.

2009-01-01

A 12b 2.9GS/s current-steering DAC implemented in 65nm CMOS is presented, with an IM3 «-60dBc beyond 1GHz while driving a 50¿ load with an output swing of 2.5Vpp-diff and dissipating a power of 188mW. The SFDR measured at 2.9GS/s is better than 60dB beyond 340MHz.

Behind the scenes of GS: Open Sesame!

CERN Multimedia

Anaïs Schaeffer

2014-01-01

The section in the GS-IS Group responsible for running the CERN Stores processes hundreds of orders per day, checks the quality of each and every product and is responsible for warehousing thousands of items available in a richly-stocked catalogue.   Sprawling across several buildings (73, 128 and 129), a total surface area of 3640 m2, and providing 28,300 cubic metres of storage space, the equivalent of 330 semi-trailers, the CERN stores are a veritable treasure trove! The products on offer range from office stationery and computer hardware to fire extinguishers, cables, steel and chemicals. The new (above) and old storage system for the CERN stores. The CERN Stores catalogue contains nearly 48,000 referenced items, 12,000 of which are available on site. Goods arrive at either Building 194 (Meyrin) or Building 904 (Prévessin) and are then forwarded to the central stores in Building 73. “Every item that arrives here undergoes a strict quality control,” says M...

Paleopathological analysis of changes on animal bones originating from archaeological sites Caricin Grad and Studenica Monastery

Directory of Open Access Journals (Sweden)

Marković Nemanja

2014-01-01

Full Text Available This work presents the estimation of incidence and analysis of paleopathological changes on skeletal remains of the animals from archaeological sites Caricin Grad and Studenica Monastery. Moreover, there has been carried out the assessment of the skeletal elements, as well as taxonomic and age determination. The total of 2595 bones or bone fragments were examined. In 22 specimens there were noticed various abnormal skeletal changes in following animal species: cattle, sheep, goats, pigs, horses, donkeys and camels. Pathological changes were noticed on the teeth, mandibles, joints of long bones and phalanxes. By macroscopic analysis of these acquired pathological changes on bones of the animals, there was determined that the observed lesions had had proliferative, hypertrophic and chronic character. Proliferative changes on the bones of the cattle, horses, donkeys and camels point out to the fact that these animals were used for towing and/or load carrying. Identified diseases of oral cavity in small ruminants point out to improper and inadequate nutrition of these animals in the past.

Glycation of polyclonal IgGs: Effect of sugar excipients during stability studies.

Science.gov (United States)

Leblanc, Y; Bihoreau, N; Jube, M; Andre, M-H; Tellier, Z; Chevreux, G

2016-05-01

A number of intravenous immunoglobulin preparations are stabilized with sugar additives that may lead over time to undesirable glycation reactions especially in liquid formulation. This study aimed to evaluate the reactivity of sugar excipients on such preparations in condition of temperature, formulation and concentration commonly used for pharmaceutical products. Through an innovative LC-MS method reported to characterize post-translational modifications of IgGs Fc/2 fragments, a stability study of IVIg formulated with reducing and non-reducing sugars has been undertaken. The rate of polyclonal IgGs glycation was investigated during 6months at 5, 25, 30 and 40°C. High levels of glycation were observed with reducing sugars such as glucose and maltose in the first months of the stability study from 25°C. Non-reducing sugars presented a low reactivity even at the highest tested temperature (40°C). Furthermore, a site by site analysis was performed by MS/MS to determine the glycation sites which were mainly identified at Lys246, Lys248 and Lys324. This work points out the high probability of glycation reactions in some commercialized products and describes a useful method to characterize IVIg glycated products issued from reducing sugar excipients. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

The Populus superoxide dismutase gene family and its responses to drought stress in transgenic poplar overexpressing a pine cytosolic glutamine synthetase (GS1a.

Directory of Open Access Journals (Sweden)

Juan Jesús Molina-Rueda

Full Text Available BACKGROUND: Glutamine synthetase (GS plays a central role in plant nitrogen assimilation, a process intimately linked to soil water availability. We previously showed that hybrid poplar (Populus tremula X alba, INRA 717-1B4 expressing ectopically a pine cytosolic glutamine synthetase gene (GS1a display enhanced tolerance to drought. Preliminary transcriptome profiling revealed that during drought, members of the superoxide dismutase (SOD family were reciprocally regulated in GS poplar when compared with the wild-type control, in all tissues examined. SOD was the only gene family found to exhibit such patterns. RESULTS: In silico analysis of the Populus genome identified 12 SOD genes and two genes encoding copper chaperones for SOD (CCSs. The poplar SODs form three phylogenetic clusters in accordance with their distinct metal co-factor requirements and gene structure. Nearly all poplar SODs and CCSs are present in duplicate derived from whole genome duplication, in sharp contrast to their predominantly single-copy Arabidopsis orthologs. Drought stress triggered plant-wide down-regulation of the plastidic copper SODs (CSDs, with concomitant up-regulation of plastidic iron SODs (FSDs in GS poplar relative to the wild type; this was confirmed at the activity level. We also found evidence for coordinated down-regulation of other copper proteins, including plastidic CCSs and polyphenol oxidases, in GS poplar under drought conditions. CONCLUSIONS: Both gene duplication and expression divergence have contributed to the expansion and transcriptional diversity of the Populus SOD/CCS families. Coordinated down-regulation of major copper proteins in drought-tolerant GS poplars supports the copper cofactor economy model where copper supply is preferentially allocated for plastocyanins to sustain photosynthesis during drought. Our results also extend previous findings on the compensatory regulation between chloroplastic CSDs and FSDs, and suggest that this

Effect of transfer of donor corneal tissue from McCarey–Kaufmann medium to Optisol-GS on corneal endothelium

Directory of Open Access Journals (Sweden)

Neha Kapur

2018-01-01

Full Text Available Purpose: The purpose of this study is to evaluate the effect of transfer of donor corneal tissue from McCarey–Kaufmann (MK medium to Optisol-GS on corneal endothelium. Methods: This was a prospective, randomized comparative study. Twenty paired human donor corneal tissues of optical quality were retrieved. One tissue of the pair was preserved in Optisol-GS preservative medium (Group A and other tissue of the pair in MK medium (Group B at the time of corneoscleral disc excision. Within 12 h of retrieval, each cornea was evaluated using slit-lamp biomicroscopic examination and specular microscopic analysis. Group B corneas were transferred to Optisol-GS medium within 48–53 h of retrieval. Specular analysis of the paired corneas was repeated 3 h after transferring to Optisol-GS. On day 7 of storage, specular analysis of both the tissues was repeated. Results: The average age of the donor at the time of death was 29 years (16–68 years. The reduction in endothelial cell count, from baseline, in Groups A and B was 5.5% and 5.8% (P = 0.938 on the 3rd day and 8.2% and 12.6% (P = 0.025 on the 7th day, respectively, postretrieval. The coefficient of variation (CV increased by 36% (P = 0.021 and hexagonality reduced by 19% (P = 0.007 on day 7. All tissues retained an endothelial cell density higher than the accepted critical level for penetrating keratoplasty. Conclusion: Significant endothelial cell loss was noted while transferring tissues from one medium to another, necessitating the need for reevaluation of transferred tissues before utilization.

Promotion of cooperation in the form C0C1D classified by 'degree grads' in a scale-free network

International Nuclear Information System (INIS)

Zhao, Li; Ye, Xiang-Jun; Huang, Zi-Gang; Sun, Jin-Tu; Yang, Lei; Wang, Ying-Hai; Do, Younghae

2010-01-01

In this paper, we revisit the issue of the public goods game (PGG) on a heterogeneous graph. By introducing a new effective topology parameter, 'degree grads' ψ, we clearly classify the agents into three kinds, namely, C 0 , C 1 , and D. The mechanism for the heterogeneous topology promoting cooperation is discussed in detail from the perspective of C 0 C 1 D, which reflects the fact that the unreasoning imitation behaviour of C 1 agents, who are 'cheated' by the well-paid C 0 agents inhabiting special positions, stabilizes the formation of the cooperation community. The analytical and simulation results for certain parameters are found to coincide well with each other. The C 0 C 1 D case provides a picture of the actual behaviours in real society and thus is potentially of interest

Three dimensional equilibrium solutions for a current-carrying reversed-field pinch plasma with a close-fitting conducting shell

Energy Technology Data Exchange (ETDEWEB)

Koliner, J. J.; Boguski, J., E-mail: boguski@wisc.edu; Anderson, J. K.; Chapman, B. E.; Den Hartog, D. J.; Duff, J. R.; Goetz, J. A.; McGarry, M.; Morton, L. A.; Parke, E. [Department of Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706 (United States); Cianciosa, M. R. [Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 (United States); Hanson, J. D. [Department of Physics, Auburn University, Auburn, Alabama 36849 (United States); Brower, D. L.; Ding, W. X. [Department of Physics and Astronomy, University of California, Los Angeles, California 90095 (United States)

2016-03-15

In order to characterize the Madison Symmetric Torus (MST) reversed-field pinch (RFP) plasmas that bifurcate to a helical equilibrium, the V3FIT equilibrium reconstruction code was modified to include a conducting boundary. RFP plasmas become helical at a high plasma current, which induces large eddy currents in MST's thick aluminum shell. The V3FIT conducting boundary accounts for the contribution from these eddy currents to external magnetic diagnostic coil signals. This implementation of V3FIT was benchmarked against MSTFit, a 2D Grad-Shafranov solver, for axisymmetric plasmas. The two codes both fit B{sub θ} measurement loops around the plasma minor diameter with qualitative agreement between each other and the measured field. Fits in the 3D case converge well, with q-profile and plasma shape agreement between two distinct toroidal locking phases. Greater than 60% of the measured n = 5 component of B{sub θ} at r = a is due to eddy currents in the shell, as calculated by the conducting boundary model.

Fifteen chord FIR polarimetry system on MTX

International Nuclear Information System (INIS)

Rice, B.W.

1992-03-01

A far-infrared (FIR) polarimeter diagnostic has been added to an existing fifteen chord interferometer on the Microwave Tokamak Experiment (MTX). The polarimeter utilizes a new technique for determination of the Faraday rotation angle based on phase measurements of a rotating polarization ellipse. This technique allows the rotation angle to be determined even in the presence of signal amplitude variations caused by refraction. The implementation of this instrument requires no new detectors and minimal optics, making it quite inexpensive to add on to existing multichord interferometers. The MTX polarimeter has been operating for about a year and has achieved a resolution of ≤0.2 degrees with a bandwidth of ≅1 kHz and a chord spacing of 1.5 cm. Typical Faraday rotation angles on MTX are in the range of 5--15 degrees. To obtain the poloidal field, the line-integrated density and Faraday rotation profiles are inverted in a manner consistent with the Grad-Shafranov equilibrium to first order in the inverse aspect-ratio expansion. Profile measurements during normal ohmic operation are presented

Status and characterization of the lithium beam diagnostic on DIII-D

Energy Technology Data Exchange (ETDEWEB)

Stoschus, H.; Hudson, B. [Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 37831-0117 (United States); Thomas, D. M.; Watkins, M.; Osborne, T. H. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Finkenthal, D. F. [Palomar College, 1140 West Mission Rd, San Marcos, California 92069-1487 (United States); Moyer, R. A. [University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093-0417 (United States)

2013-08-15

The 30 keV lithium beam diagnostic on DIII-D is suitable to measure both the radial electron density and poloidal magnetic field profiles in the pedestal. The refurbished system features a new setup to measure the Doppler shift allowing accurate alignment of the spectral filters. The injector has been optimized to generate a stable lithium neutral beam with a current of I= 15−20 mA and a diameter of 1.9 ± 0.1 cm measured by beam imaging. The typical temporal resolution is Δt= 1−10 ms and the radial resolution of ΔR= 5 mm is given by the optical setup. A new analysis technique based on fast Fourier transform avoids systematic error contributions from the digital lock-in analysis and accounts intrinsically for background light correction. Latest upgrades and a detailed characterization of the system are presented. Proof-of-principle measurements of the poloidal magnetic field with a statistical error of typically 2% show a fair agreement with the predictions modeled with the Grad-Shafranov equilibrium solver EFIT within 4%.

PlasmaPy: initial development of a Python package for plasma physics

Science.gov (United States)

Murphy, Nicholas; Leonard, Andrew J.; Stańczak, Dominik; Haggerty, Colby C.; Parashar, Tulasi N.; Huang, Yu-Min; PlasmaPy Community

2017-10-01

We report on initial development of PlasmaPy: an open source community-driven Python package for plasma physics. PlasmaPy seeks to provide core functionality that is needed for the formation of a fully open source Python ecosystem for plasma physics. PlasmaPy prioritizes code readability, consistency, and maintainability while using best practices for scientific computing such as version control, continuous integration testing, embedding documentation in code, and code review. We discuss our current and planned capabilities, including features presently under development. The development roadmap includes features such as fluid and particle simulation capabilities, a Grad-Shafranov solver, a dispersion relation solver, atomic data retrieval methods, and tools to analyze simulations and experiments. We describe several ways to contribute to PlasmaPy. PlasmaPy has a code of conduct and is being developed under a BSD license, with a version 0.1 release planned for 2018. The success of PlasmaPy depends on active community involvement, so anyone interested in contributing to this project should contact the authors. This work was partially supported by the U.S. Department of Energy.

Amperometric Immunosensor for Carbofuran Detection Based on MWCNTs/GS-PEI-Au and AuNPs-Antibody Conjugate

Directory of Open Access Journals (Sweden)

Xiangyou Wang

2013-04-01

Full Text Available In this paper, an amperometric immunosensor for the detection of carbofuran was developed. Firstly, multiwall carbon nanotubes (MWCNTs and graphene sheets-ethyleneimine polymer-Au (GS-PEI-Au nanocomposites were modified onto the surface of a glass carbon electrode (GCE via self-assembly. The nanocomposites can increase the surface area of the GCE to capture a large amount of antibody, as well as produce a synergistic effect in the electrochemical performance. Then the modified electrode was coated with gold nanoparticles-antibody conjugate (AuNPs-Ab and blocked with BSA. The monoclonal antibody against carbofuran was covalently immobilized on the AuNPs with glutathione as a spacer arm. The morphologies of the GS-PEI-Au nanocomposites and the fabrication process of the immunosensor were characterized by X-ray diffraction (XRD, ultraviolet and visible absorption spectroscopy (UV-vis and scanning electron microscopy (SEM, respectively. Under optimal conditions, the immunosensor showed a wide linear range, from 0.5 to 500 ng/mL, with a detection limit of 0.03 ng/mL (S/N = 3. The as-constructed immunosensor exhibited notable performance features such as high specificity, good reproducibility, acceptable stability and regeneration performance. The results are mainly due to the excellent properties of MWCNTs, GS-PEI-Au nanocomposites and the covalent immobilization of Ab with free hapten binding sites for further immunoreaction. It provides a new avenue for amperometric immunosensor fabrication.

Glutathione Preservation during Storage of Rat Lenses in Optisol-GS and Castor Oil

DEFF Research Database (Denmark)

Holm, Thomas; Brøgger-Jensen, Martin Rocho; Johnson, Leif

2013-01-01

Glutathione concentration in the lens decreases in aging and cataractous lenses, providing a marker for tissue condition. Experimental procedures requiring unfrozen lenses from donor banks rely on transportation in storage medium, affecting lens homeostasis and alterations in glutathione levels. ....... The aim of the study was to examine the effects of Optisol-GS and castor oil on lens condition, determined from their ability to maintain glutathione concentrations....

MAXI/GSC detection of a hard-to-soft transition of NS-LMXB GS 1826-238

Science.gov (United States)

Nakahira, S.; Mihara, T.; Sugizaki, M.; Serino, M.; Morii, M.; Sugimoto, J.; Takagi, T.; Yoshikawa, A.; Matsuoka, M.; Kawai, N.; Yoshii, T.; Tachibana, Y.; Ueno, S.; Tomida, H.; Kimura, M.; Ishikawa, M.; Nakagawa, Y. E.; Negoro, H.; Nakajima, M.; Fukushima, K.; Onodera, T.; Suzuki, K.; Fujita, M.; Namba, T.; Honda, F.; Yoshida, A.; Sakamoto, T.; Kawakubo, Y.; Ohtsuki, H.; Tsunemi, H.; Uchida, D.; Ueda, Y.; Shidatsu, M.; Kawamuro, T.; Hori, T.; Kawagoe, A.; Tsuboi, Y.; Yamauchi, M.; Morooka, Y.; Yamaoka, K.

2014-06-01

We report on a hard-to-soft spectral transition of an X-ray burster GS 1826-238 detected with MAXI/GSC. This source had been consistently observed in the hard state for more than 25 years since the discovery in 1988 (Tanaka 1989, Barret et al. ...

DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers

International Nuclear Information System (INIS)

Pippa, Natassa; Kaditi, Eleni; Pispas, Stergios; Demetzos, Costas

2013-01-01

In this study, we report on the self assembly behavior and on stability studies of mixed (chimeric) nanosystems consisting of dipalmitoylphosphatidylcholine (DPPC) and poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (MPOx) gradient copolymer in aqueous media and in fetal bovine serum (FBS). A gamut of light scattering techniques and fluorescence spectroscopy were used in order to extract information on the size and morphological characteristics of the nanoassemblies formed, as a function of gradient block copolymer content, as well as temperature. The hydrodynamic radii (R h ) of nanoassemblies decreased in the process of heating up to 50 °C, while the fractal dimension (d f ) values, also increased. Indomethacin was successfully incorporated into these chimeric nanocarriers. Drug release was depended on the components ratio. The present studies show that there are a number of parameters that can be used in order to alter the properties of chimeric nanosystems, and this is advantageous to the development of “smart” nanocarriers for drug delivery.

NON DESTRUCTIVE APPLICATION OF RADIOACTIVE TRACER TECHNIQUE FOR CHARACTERIZATION OF INDUSTRIAL GRADE ANION EXCHANGE RESINS INDION GS-300 AND INDION-860

Directory of Open Access Journals (Sweden)

P.U. SINGARE

2014-02-01

Full Text Available The paper deals with the application of radio isotopic non-destructive technique in the characterization of two industrial grade anion exchange resins Indion GS-300 and Indion-860. For the characterization of the two resins, 131I and 82Br were used as tracer isotopes to trace the kinetics of iodide and bromide ion-isotopic exchange reactions. It was observed that the values of specific reaction rate (min−1, amount of iodide ion exchanged (mmol, initial rate of iodide ion exchange (mmol/min and log Kd were calculated as 0.328, 0.577, 0.189 and 19.7 respectively for Indion GS-300 resin, which was higher than the respective values of 0.180, 0.386, 0.070 and 17.0 calculated for Indion-860 resins when measured under identical experimental conditions. Also at a constant temperature of 40.0 °C, as the concentration of labeled iodide ion solution increases 0.001 M to 0.004 M, the percentage of iodide ions exchanged increases from 75.16 % to 78.36 % for Indion GS-300 resins, which was higher than the increases from 49.65 % to 52.36 % compared to that obtained for Indion-860 resins. The overall results indicate that under identical experimental conditions, Indion GS-300 resins show superior performance over Indion-860 resins.

Genetic divergence for high-molecular weight glutenin subunits (HMW-GS) in indigenous landraces and commercial cultivars of bread wheat of Pakistan.

Science.gov (United States)

Yasmeen, F; Khurshid, H; Ghafoor, A

2015-05-11

Wheat flour quality is an important consideration in the breeding and development of new cultivars. A strong association between high-molecular weight glutenin subunits (HMW-GS) and bread making quality has resulted in the widespread utilization of HMW-GS in wheat breeding. In this study, we analyzed 242 lines of wheat, including landraces from the provinces of Punjab and Baluchistan, as well as the commercial varieties of Pakistan, to determine allelic variation in the Glu-A1, Glu-B1, and Glu-D1 loci encoding HMW-GS. Higher genetic diversity was observed for HMW-GS in landraces from Baluchistan, followed by landraces collected from Punjab and then commercial varieties. Rare and uncommon subunits were observed in Glu-B1, whereas Glu-A1 was less polymorphic. However, Glu-B1 was the highest contributor to overall diversity (78%), with a total of 31 rare alleles, followed by Glu-D1 (20%) with the high quality 5+10 allele and other variants. Commercial cultivars possessed favorable alleles, potentially from indirect selection for wheat flour quality by the breeders; however, this indirect selection has decreased the pedigree base of commercial cultivars. The allelic combinations, including 2*, 5+10, and 17+18, showing high quality scores were frequent among landraces, indicating their usefulness in future crop improvement and breeding programs.

Non Destructive Application of Radioactive Tracer Technique for Characterization of Industrial Grade Anion Exchange Resins Indio GS-300 and Indion-860

International Nuclear Information System (INIS)

Singare, P. U.

2014-01-01

The paper deals with the application of radio isotopic non-destructive technique in the characterization of two industrial grade anion exchange resins Indion GS-300 and Indion-860. For the characterization of the two resins, 131 I and 82 Br were used as tracer isotopes to trace the kinetics of iodide and bromide ion-isotopic exchange reactions. It was observed that the values of specific reaction rate (min -1 ), amount of iodide ion exchanged (mmol), initial rate of iodide ion exchange (mmol/min) and log K d were calculated as 0.328, 0.577, 0.189 and 19.7 respectively for Indion GS-300 resin, which was higher than the respective values of 0.180, 0.386, 0.070 and 17.0 calculated for Indion-860 resins when measured under identical experimental conditions. Also at a constant temperature of 40.0 .deg. C, as the concentration of labeled iodide ion solution increases 0.001 M to 0.004 M, the percentage of iodide ions exchanged increases from 75.16 % to 78.36 % for Indion GS-300 resins, which was higher than the increases from 49.65 % to 52.36 % compared to that obtained for Indion-860 resins. The overall results indicate that under identical experimental conditions, Indion GS-300 resins show superior performance over Indion-860 resins

Improved stress tolerance and productivity in transgenic rice plants constitutively expressing the Oryza sativa glutathione synthetase OsGS under paddy field conditions.

Science.gov (United States)

Park, Seong-Im; Kim, Young-Saeng; Kim, Jin-Ju; Mok, Ji-Eun; Kim, Yul-Ho; Park, Hyang-Mi; Kim, Il-Sup; Yoon, Ho-Sung

2017-08-01

Reactive oxygen species, which increase under various environmental stresses, have deleterious effects on plants. An important antioxidant, glutathione, is used to detoxify reactive oxygen species in plant cells and is mainly produced by two enzymes: gamma-glutamylcysteine synthetase (γ-ECS) and glutathione synthetase (GS). To evaluate the functional roles of the glutathione synthetase gene (OsGS) in rice, we generated four independent transgenic rice plants (TG1-TG4) that overexpressed OsGS under the control of the constitutively expressed OsCc1 promoter. When grown under natural paddy field conditions, the TG rice plants exhibited greater growth development, higher chlorophyll content, and higher GSH/GSSH ratios than control wild-type (WT) rice plants. Subsequently, the TG rice plants enhanced redox homeostasis by preventing hydroperoxide-mediated membrane damage, which improved their adaptation to environmental stresses. As a result, TG rice plants improved rice grain yield and total biomass following increases in panicle number and number of spikelets per panicle, despite differences in climate during the cultivation periods of 2014 and 2015. Overall, our results indicate that OsGS overexpression improved redox homeostasis by enhancing the glutathione pool, which resulted in greater tolerance to environmental stresses in the paddy fields. Copyright © 2017. Published by Elsevier GmbH.

Resonant cell of a double nuclear electron resonance spectrometer for performance in a 120-350 Gs magnetic field

International Nuclear Information System (INIS)

Baldin, V.I.; Stepanov, A.P.

1976-01-01

Spectrometer double-frequency resonance cell construction of a double nuclear electron resonance for operation in 120-350 Gs magnetic fields is described. The cell has been developed from a special decimeter resonator with a concentrated capacitance. The electric and magnetic components of a high frequency field are efficiently divided in the separator. Therefore, the insertion of a measuring coil and a sample in the maximum of the magnetic component of the field does not practically affect the distribution and parameters of the high-frequency field. The double-frequency resonance cell proposed provides for a higher accuracy of measuring amplifications of the nuclear magnetic resonance signals when there is the overhauzer effect for 120-350 Gs magnetic fields

Behind the scenes of GS: Sweet dreams!

CERN Multimedia

Anaïs Schaeffer

2014-01-01

The CERN Hostel is located in the heart of the Meyrin site and provides the Organization’s many users with a comfortable and peaceful place to stay. The services offered by the Hostel, which is managed by the GS-IS Group, have seen many changes over the years.   The first CERN Hostel (Building 38) was built in 1982 in response to an increasing demand for accommodation, which until then had been met by a handful of converted bedrooms in Building 5 and, since 1974, by 81 additional bedrooms made available to CERN through an agreement with the Foyer Schumann in Saint-Genis-Pouilly. Let’s not even mention the fact that the barracks now occupied by the CERN clubs used to be dormitories… The Hostel was gradually extended, particularly in 1995 with the construction of Building 39, and then in 2007, when Building 41 was added, resulting in a total of 413 rooms (495 beds) today. In addition, a new agreement now gives users access to 151 low-cost rooms at the Foyer Schuma...

Behind the scenes of GS: precious stones

CERN Multimedia

Anaïs Schaeffer

2014-01-01

Since the laying of the foundation stone for the Synchrocyclotron in June 1954, CERN has been expanding constantly to reach a current constructed surface area of 580,000 m2 covered by some 650 buildings (just 125 of which account for 70% of this area).   This year, while CERN’s 60th anniversary is an important milestone in the Laboratory’s history, it also highlights another reality: CERN is a collection of ageing buildings, no less than 60% of which are more than 40 years old. “Of the 580,000 m2 of buildings, around 52,000 m2 are nearing the end of their useful life and 140,000 m2 are in need of extensive renovations,” says Natacha Lopez, GS-SE-PO Section Leader. “Of course, we’ve already started several renovation projects, but it's a huge challenge as we have to renovate buildings constructed in the 1960s and 70s while complying with modern standards, which are very different from those that were in force when they were bu...

THE FAST DECLINING TYPE Ia SUPERNOVA 2003gs, AND EVIDENCE FOR A SIGNIFICANT DISPERSION IN NEAR-INFRARED ABSOLUTE MAGNITUDES OF FAST DECLINERS AT MAXIMUM LIGHT

International Nuclear Information System (INIS)

Krisciunas, Kevin; Marion, G. H.; Suntzeff, Nicholas B.

2009-01-01

We obtained optical photometry of SN 2003gs on 49 nights, from 2 to 494 days after T(B max ). We also obtained near-IR photometry on 21 nights. SN 2003gs was the first fast declining Type Ia SN that has been well observed since SN 1999by. While it was subluminous in optical bands compared to more slowly declining Type Ia SNe, it was not subluminous at maximum light in the near-IR bands. There appears to be a bimodal distribution in the near-IR absolute magnitudes of Type Ia SNe at maximum light. Those that peak in the near-IR after T(B max ) are subluminous in the all bands. Those that peak in the near-IR prior to T(B max ), such as SN 2003gs, have effectively the same near-IR absolute magnitudes at maximum light regardless of the decline rate Δm 15 (B). Near-IR spectral evidence suggests that opacities in the outer layers of SN 2003gs are reduced much earlier than for normal Type Ia SNe. That may allow γ rays that power the luminosity to escape more rapidly and accelerate the decline rate. This conclusion is consistent with the photometric behavior of SN 2003gs in the IR, which indicates a faster than normal decline from approximately normal peak brightness.

An 11b 3.6GS/s time-Iiterleaved SAR ADC in 65nm CMOS

NARCIS (Netherlands)

Janssen, E.J.G.; Doris, K.; Zanikopoulos, A.; Murroni, A.; Weide, van der G.; Lin, Y.; Alvado, L.; Darthenay, F.; Fregeais, Y.

2013-01-01

Over the last years several low-power time-interleaved (TI) ADC designs in the 2.5-to-3.0GS/s range have been published [1-3], intended for integration in applications like radar, software-defined radio, full-spectrum cable modems, and multi-channel satellite reception. It is to be expected that

Analytical modeling of equilibrium of strongly anisotropic plasma in tokamaks and stellarators

International Nuclear Information System (INIS)

Lepikhin, N. D.; Pustovitov, V. D.

2013-01-01

Theoretical analysis of equilibrium of anisotropic plasma in tokamaks and stellarators is presented. The anisotropy is assumed strong, which includes the cases with essentially nonuniform distributions of plasma pressure on magnetic surfaces. Such distributions can arise at neutral beam injection or at ion cyclotron resonance heating. Then the known generalizations of the standard theory of plasma equilibrium that treat p ‖ and p ⊥ (parallel and perpendicular plasma pressures) as almost constant on magnetic surfaces are not applicable anymore. Explicit analytical prescriptions of the profiles of p ‖ and p ⊥ are proposed that allow modeling of the anisotropic plasma equilibrium even with large ratios of p ‖ /p ⊥ or p ⊥ /p ‖ . A method for deriving the equation for the Shafranov shift is proposed that does not require introduction of the flux coordinates and calculation of the metric tensor. It is shown that for p ⊥ with nonuniformity described by a single poloidal harmonic, the equation for the Shafranov shift coincides with a known one derived earlier for almost constant p ⊥ on a magnetic surface. This does not happen in the other more complex case

The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology.

Science.gov (United States)

Wong, Rebecca; Levi, Angelique W; Harigopal, Malini; Schofield, Kevin; Chhieng, David C

2012-02-01

Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought to address these issues by introducing new technology and lean principles. To determine the combined impact of the FocalPoint Guided Screener (GS) Imaging System (BD Diagnostics-TriPath, Burlington, North Carolina) and lean manufacturing principles on the turnaround time (TAT) and productivity of the gynecologic cytology operation. We established a baseline measure of the TAT for Papanicolaou tests. We then compared that to the performance after implementing the FocalPoint GS Imaging System and lean principles. The latter included value-stream mapping, workflow modification, and a first in-first out policy. The mean (SD) TAT for Papanicolaou tests before and after the implementation of FocalPoint GS Imaging System and lean principles was 4.38 (1.28) days and 3.20 (1.32) days, respectively. This represented a 27% improvement in the average TAT, which was statistically significant (P implementation of FocalPoint GS Imaging System in conjunction with lean principles resulted in a significant decrease in the average TAT for Papanicolaou tests and a substantial increase in the productivity of cytotechnologists while maintaining the diagnostic quality of gynecologic cytology.

Behind the scenes of GS: keeping CERN clean

CERN Document Server

Antonella Del Rosso

2014-01-01

More than 350,000 square metres to be maintained, two different cleaning companies due to CERN’s sites being in two different countries, underground installations where cleanliness is a question of safety… the CERN team in charge of supervising cleaning services overcomes all these challenges to ensure that our workplace remains clean and pleasant every day.   Ensuring the cleanliness of sites containing a huge variety of buildings is an enormous challenge for the two experts in the GS Department in charge of cleaning services. Alain Bertrand has been at CERN for 29 years and knows all there is to know about the Organization’s buildings and what they are used for, the condition of their toilet facilities and, of course, the location of the border between France and Switzerland which, in terms of cleaning services, denotes the transition point between the two companies used. David Chameaux has been doing the same job as Alain for two years, working with him to ensu...

Nustar Detection of Hard X-Ray Phase Lags from the Accreting Pulsar GS 0834-430

DEFF Research Database (Denmark)

Miyasaka, Hiromasa; Bachetti, Matteo; Harrison, Fiona A.

2013-01-01

The Nuclear Spectroscopic Telescope Array hard X-ray telescope observed the transient Be/X-ray binary GS 0834-430 during its 2012 outburst-the first active state of this system observed in the past 19 yr. We performed timing and spectral analysis and measured the X-ray spectrum between 3-79 keV w...

MAGNETIC ENERGY BUILDUP FOR RELATIVISTIC MAGNETAR GIANT FLARES

International Nuclear Information System (INIS)

Yu Cong

2011-01-01

Motivated by coronal mass ejection studies, we construct general relativistic models of a magnetar magnetosphere endowed with strong magnetic fields. The equilibrium states of the stationary, axisymmetric magnetic fields in the magnetar magnetosphere are obtained as solutions of the Grad-Shafranov equation in a Schwarzschild spacetime. To understand the magnetic energy buildup in the magnetar magnetosphere, a generalized magnetic virial theorem in the Schwarzschild metric is newly derived. We carefully address the question whether the magnetar magnetospheric magnetic field can build up sufficient magnetic energy to account for the work required to open up the magnetic field during magnetar giant flares. We point out the importance of the Aly-Sturrock constraint, which has been widely studied in solar corona mass ejections, as a reference state in understanding magnetar energy storage processes. We examine how the magnetic field can possess enough energy to overcome the Aly-Sturrock energy constraint and open up. In particular, general relativistic (GR) effects on the Aly-Sturrock energy constraint in the Schwarzschild spacetime are carefully investigated. It is found that, for magnetar outbursts, the Aly-Sturrock constraint is more stringent, i.e., the Aly-Sturrock energy threshold is enhanced due to the GR effects. In addition, neutron stars with greater mass have a higher Aly-Sturrock energy threshold and are more difficult to erupt. This indicates that magnetars are probably not neutron stars with extreme mass. For a typical neutron star with mass of 1-2 M sun , we further explore the cross-field current effects, caused by the mass loading, on the possibility of stored magnetic field energy exceeding the Aly-Sturrock threshold.

DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers

Energy Technology Data Exchange (ETDEWEB)

Pippa, Natassa [Faculty of Pharmacy, National and Kapodistrian University of Athens, Department of Pharmaceutical Technology (Greece); Kaditi, Eleni; Pispas, Stergios [Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation (Greece); Demetzos, Costas, E-mail: demetzos@pharm.uoa.gr [Faculty of Pharmacy, National and Kapodistrian University of Athens, Department of Pharmaceutical Technology (Greece)

2013-06-15

In this study, we report on the self assembly behavior and on stability studies of mixed (chimeric) nanosystems consisting of dipalmitoylphosphatidylcholine (DPPC) and poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (MPOx) gradient copolymer in aqueous media and in fetal bovine serum (FBS). A gamut of light scattering techniques and fluorescence spectroscopy were used in order to extract information on the size and morphological characteristics of the nanoassemblies formed, as a function of gradient block copolymer content, as well as temperature. The hydrodynamic radii (R{sub h}) of nanoassemblies decreased in the process of heating up to 50 Degree-Sign C, while the fractal dimension (d{sub f}) values, also increased. Indomethacin was successfully incorporated into these chimeric nanocarriers. Drug release was depended on the components ratio. The present studies show that there are a number of parameters that can be used in order to alter the properties of chimeric nanosystems, and this is advantageous to the development of 'smart' nanocarriers for drug delivery.

NICER Discovers mHz Oscillations and Marginally Stable Burning in GS 1826-24

Science.gov (United States)

Strohmayer, Tod E.; Gendreau, Keith C.; Keek, Laurens; Bult, Peter; Mahmoodifar, Simin; Chakrabarty, Deepto; Arzoumanian, Zaven; NICER Science Team

2018-01-01

To date, marginally stable thermonuclear burning, evidenced as mHz X-ray flux oscillations, has been observed in only five accreting neutron star binaries, 4U 1636-536, 4U 1608-52, Aql X-1, 4U 1323-619 and Terzan 5 X-2. Here we report the discovery with NASA's Neutron Star Interior Composition Explorer (NICER) of such oscillations from the well-known X-ray burster GS 1826-24. NICER observed GS 1826-24 on 9 September, 2017 for a total exposure of about 4 ksec. Timing analysis revealed highly significant oscillations at a frequency of 8.2 mHz in two successive pointings. The oscillations have a fractional modulation amplitude of approximately 3% for photon energies less than 6 keV. The observed frequency is consistent with the range observed in the other mHz QPO systems, and indeed is slightly higher than the frequency measured in 4U 1636-536 below which mHz oscillations ceased and unstable burning (X-ray bursts) resumed. We discuss the mass accretion rate dependence of the oscillations as well as the X-ray spectrum as a function of pulsation phase. We place the observations in the context of the current theory of marginally stable burning and briefly discuss the potential for constraining neutron star properties using mHz oscillations.

Antifoaming materials in G.S. (Girlder sulfide) heavy water plants. Thermical stability. Pt. 2

International Nuclear Information System (INIS)

Delfino, C.A.

1986-01-01

In Girlder sulfide (G.S.) heavy water plants hydrogen sulfide-water systems are inherentely foaming, so the adding of antifoaming materials is of great importance. These may be of high volatility, pyrolizable or chemically unstable in plant operation conditions (water and hydrogen sulfide at 2 MPa, up to 230 deg C). About twenty commercial surfactants were studied from the point of view of their thermical stability. (Author) [es

MBI-GS: APLICAÇÃO E VERIFICAÇÃO PSICOMÉTRICA NA REALIDADE BRASILEIRA

Directory of Open Access Journals (Sweden)

Marcelo da Silva Schuster

2015-03-01

Full Text Available O presente estudo tem por objetivo verificar a aplicação da escala MBI-GS (Maslach Burnout Inventory e suas três dimensões (exaustão, cinismo e eficácia no trabalho em um hospital público brasileiro com uma população de servidores da área médica e administrativa, caracterizando assim o uso da versão General Survey. A amostra considerada para efeito das análises realizadas foi de 173 profissionais, através da aplicação de questionário estruturado. Os dados foram submetidos a análises quantitativas (análise fatorial exploratória, confiabilidade, teste de correlação e regressão. Os resultados apontam para a aplicabilidade da escala, após procedimentos fatoriais, a escala ficou com 15 variáveis permanecendo com três fatores, apresentando uma confiabilidade de 0,87. A síndrome Burnout correlacionou-se a percepção de Saúde dos trabalhadores, confirmando relação causal na saúde dos trabalhadores. O estudo contribui para o estudo de Burnout no Brasil com a aplicação da MBI-GS de forma inédita em um Hospital Público.

Management Systems and Safety Culture in the Nuclear Energy Sector (ISO 9001 & GS-R-3)

International Nuclear Information System (INIS)

Smetnik, A.; Murlis, D.

2016-01-01

Nowadays, the enterprises of the Rosatom State Nuclear Energy Corporation that provides products and services to foreign customers should rely on the requirements to the management systems established by the IAEA Standard GS-R-3 “The management system for facilities and activities”. This results from the fact that in order to enter foreign markets, Russian suppliers have to meet foreign requirements related to quality assurance, protection of the environment, nuclear and radiation safety, etc. For instance, the Finnish customer “Fennovoima” requires full compliance of the management systems of the Russian companies involved in the construction of the Hanhikivi-1 NPP with the GS-R-3 Standard. ISO 9001 quality management systems were widely implemented in the nuclear industry enterprises in Russia. The assessment of compliance of the quality management systems with the established requirements is carried out by the certification bodies. The same relates to the environmental management systems that are implemented at the majority of nuclear industry facilities in Russia. But due to their uniqueness and associated significant risks, the nuclear industry enterprises have to meet current safety requirements and principles established in the IAEA Safety Standards, such as safety culture and risk management.

Influence of induction hardening parameters on the GS30Mn5 weld properties

Directory of Open Access Journals (Sweden)

V. Marušić

2016-10-01

Full Text Available This study examines parameters of post-weld heat treatment on the test specimens made of cast steel GS30Mn5. The welding is performed with shielded metal arc welding (SMAW process. The aim is to obtain the surface without illicit cracks, with hardness ranging from 320 up to 400 HB. After induction heating, the specimens are cooled alternately with air and water. Decreased speed of quenching results in avoiding the occurrence of illicit splashes, while the hardness is maintained within the prescribed limits.

Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage

DEFF Research Database (Denmark)

Lachmann, Peter; Hickmann, Linda; Steglich, Anne

2017-01-01

Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility...... in the maintenance and protection of the renal microvascular endothelium....

Error de medición alrededor de los puntos de corte en el MBI-GS

Directory of Open Access Journals (Sweden)

Manuel Fernández Arata

2014-12-01

Full Text Available Resumen En la calificación de los resultados del MBI-GS (Maslach Burnout Inventory - General Survey como de sus antecesores, se usan interpretaciones dimensionales, pero también puntos de corte para clasificar a los sujetos y diferenciarlos con respecto a la presencia del síndrome de burnout. Sin embargo, este uso está orientado al tipo de tests referidos a criterios, por lo que la estimación de la confiabilidad debe converger con este tipo de uso. El objetivo del presente estudio fue estimar la confiabilidad alrededor de varios puntos de corte en el MBI-GS (agotamiento emocional, eficacia profesional y cinismo, mediante el coeficiente K2 de Livingston. Los participantes fueron 741 sujetos de varias ocupaciones, provenientes de instituciones públicas y privadas de Lima y de otras ciudades. Previo a la obtención de la confiabilidad criterial, se verificó la unidimensionalidad, el modelo equivalente tau, la distribución y la bimodalidad de los puntajes. Se halló que los puntos de corte más extremos muestran mayor confiabilidad; que la confiabilidad se incrementa en relación al grado de extremidad de los puntajes; que el puntaje de agotamiento emocional obtiene mayor confiabilidad criterial y que cinismo obtiene la menor, pero todos los puntajes generalmente muestran buenas confiabilidades. Se discute el uso de los puntos de corte en relación a su validez y confiabilidad. Abstract In the rating of the MBI-GS results (Maslach Burnout Inventory - General Survey as its predecessors, we used dimensional interpretations, but also cut-off points for classifying and differentiating the subjects with respect to the presence of the burnout syndrome. However, this use is oriented to the type of tests relating to criteria so that the estimate of the reliability must converge with this type of use. The objective of this study was to estimate the reliability around various cutting points in the MBI-GS (emotional exhaustion, professional

New insights into urban planning of Caričin Grad: The application of modern sensing and detection methods

Directory of Open Access Journals (Sweden)

Ivanišević Vujadin

2016-01-01

Full Text Available Caričin Grad, Justiniana Prima, urban planning, fortification, settlement, aerial photography, geophysical surveys, LiDAR, photogrammetry, excavations, GIS. Thanks to the application of modern non-destructive sensing and detection methods, in recent years a series of new data on urban planning in Caričin Grad was obtained. For the most part, the current research programme studies the Upper Town’s northern plateau, wooded until recently and hence the only previously unexplored unit of the city. In the course of this programme, the classical research method - the excavations started in 2009 - is for the first time combined with the systematic application of airborne and terrestrial sensing and detection techniques. The analysis of historic aerial photographs and topographic plans proved to be very useful as well. Along with them, LiDAR-derived DTMs, photogrammetric DEMs, different geophysical and orthophotographic plans are stored in the GIS database for Caričin Grad and the Leskovac Basin. In this way almost 80 percent of the plateau area was defined, and the obtained plan is hypothetical only to a small extent, which particularly refers to the unexcavated northern rampart of the Upper Town. Each source provided relevant information for the reconstruction of both the rampart and the settlement, which points to the value of a holistic approach to documentation from various dates. The first source to be studied were archival aerial photographs of Caričin Grad from 1938 and 1947 (Figs. 1, 2.1. The latter one was originally processed by Aleksandar Deroko and Svetozar Radojči}, who drew the plan of the town after it, labelling the unexplored Upper Town’s northern plateau as “a probable habitation area”. The route of the northern rampart was aslo rather precisely determined by the authors (Fig. 2.2. Recently, these photographs were rectified and georeferenced in the GIS. The 1938 shot reveals the position of some towers as well, and it is

Therapeutic Efficacy of the Small Molecule GS-5734 against Ebola virus in Rhesus Monkeys

Science.gov (United States)

2016-03-02

culture. The diastereomeric mixture at phosphorous 858 containing GS-5734 was incubated continuously for 72 h at 1 µM and levels of intracellular NTP...constants (J) in Hertz. Analytical thin–layer chromatography was performed using Merck KGaA Silica gel 60 F254 glassplates with UV visualization. Preparative...trifluoroacetic acid in water and 0.1% trifluoroacetic acid in acetonitrile; flow rate, 2 mL/min; acquisition time, 6 min; wavelength, UV 214 and 254 nm

Behind the scenes of GS: Service orientation CERN-wide

CERN Multimedia

Corinne Pralavorio

2014-01-01

A far-reaching project to improve the management of services was initiated in 2010, through the implementation of standard methods and tools to improve the efficiency of CERN services continuously.   Everyone at CERN now knows the telephone number 77777, the e-mail address service-desk@cern.ch and the CERN Service Portal. Behind all this lies a one-stop-shop where a team of operators is ready to answer your call as swiftly as possible and help you send that over-sized parcel to Patagonia or repair those faulty blinds (see Bulletin article 44-45/2013). But that’s not all, as Reinoud Martens, head of the Service Management Support Group in the GS Department, explains: “As far as the service management project is concerned, receiving and assigning incoming calls is just the tip of the iceberg! More generally, the aim of this massive project, launched in 2010 in close collaboration with the IT Department, is to enhance service management and implement standardised met...

Behind the scenes of GS: security affects us all

CERN Multimedia

Antonella Del Rosso

2014-01-01

A CERN manager, supported by two outside companies, manages the three entities in the GS Department that are in charge of various aspects of security. In total, about 80 people, 300 cameras, a surveillance centre (CSA) and 22 kilometres of fences are responsible for ensuring that the Organization is secure. But in spite of these significant resources, the best strategy for maintaining a good level of security at CERN is the active support of its users.   CERN’s security service covers three main areas: access control, comprising the security guards and a patrol service that ensures the site is secure and monitors compliance with traffic and parking rules; registration; and locks and keys. The 22 guards on the day shift and the seven on the night shift, who constantly monitor access, are spread across the two main sites and the four experiment sites. “The guards’ main job is to check that only those who are authorised to do so enter the site,” explains...

EFIT tokamak equilibria with toroidal flow and anisotropic pressure using the two-temperature guiding-centre plasma

International Nuclear Information System (INIS)

Fitzgerald, M.; Hole, M.J.; Appel, L.C.

2013-01-01

A new force balance model for the EFIT magnetohydrodynamic equilibrium technique for tokamaks is presented which includes the full toroidal flow and anisotropy changes to the Grad–Shafranov equation. The free functions are poloidal flux functions and all non-linear contributions to the toroidal current density are treated iteratively. The parallel heat flow approximation chosen for the model is that parallel temperature is a flux function and that both parallel and perpendicular pressures may be described using parallel and perpendicular temperatures. This choice for the fluid thermodynamics has been shown elsewhere to be the same as a guiding-centre kinetic solution of the same problem under the same assumptions. The model reduces identically to the static and isotropic Grad–Shafranov equation in the appropriate limit as different flux functions are set to zero. An analytical solution based on a modified Soloviev solution for non-zero toroidal flow and anisotropy is also presented. The force balance model has been demonstrated in the code EFIT TENSOR, a branch of the existing code EFIT++. Benchmark results for EFIT TENSOR are presented and the more complicated force balance model is found to converge to force balance similarly to the usual EFIT model and with comparable speed. (paper)

Advanced ECCD based NTM control in closed-loop operation at ASDEX Upgrade (AUG)

Science.gov (United States)

Reich, Matthias; Barrera-Orte, Laura; Behler, Karl; Bock, Alexander; Giannone, Louis; Maraschek, Marc; Poli, Emanuele; Rapson, Chris; Stober, Jörg; Treutterer, Wolfgang

2012-10-01

In high performance plasmas, Neoclassical Tearing Modes (NTMs) are regularly observed at reactor-grade beta-values. They limit the achievable normalized beta, which is undesirable because fusion performance scales as beta squared. The method of choice for controlling and avoiding NTMs at AUG is the deposition of ECCD inside the magnetic island for stabilization in real-time (rt). Our approach to tackling such complex control problems using real-time diagnostics allows rigorous optimization of all subsystems. Recent progress in rt-equilibrium reconstruction (< 3.5 ms), rt-localization of NTMs (< 8 ms) and rt beam tracing (< 25 ms) allows closed-loop feedback operation using multiple movable mirrors as the ECCD deposition actuator. The rt-equilibrium uses function parametrization or a fast Grad-Shafranov solver with an option to include rt-MSE measurements. The island localization is based on a correlation of ECE and filtered Mirnov signals. The rt beam-tracing module provides deposition locations and their derivative versus actuator position of multiple gyrotrons. The ``MHD controller'' finally drives the actuators. Results utilizing closed-loop operation with multiple gyrotrons and their effect on NTMs are shown.

Current Profile and Magnetic Structure Measurements through Tangential Soft X-Ray Imaging in Compact Tori

International Nuclear Information System (INIS)

Fonck, Raymond J.

2004-01-01

This report describes the fabrication and tests of a tangentially imaging soft X-ray (SXR) camera diagnostic for fusion energy plasma research. It can be used for the determination of the current distribution in strongly shaped toroidal magnetically confined plasmas, such as those found in spherical tori or advanced tokamaks. It included the development of both an appropriate imaging SXR camera and image analysis techniques necessary to deduce the plasma shape and current distribution. The basic camera concept consists of a tangentially viewing pinhole imaging system with thin-film SXR filters, a scintillator screen to provide SXR to visible conversion, a fast shuttering system, and an sensitive visible camera imaging device. The analysis approach consists of integrating the 2-D SXR image data into a Grad-Shafranov toroidal equilibrium solver code to provide strong constraints on the deduced plasma current and pressure profiles. Acceptable sensitivity in the deduced current profile can be obtained if the relative noise in the measured image can be kept in the range of 1% or less. Tests on the Pegasus Toroidal Experiment indicate very flat safety factor profiles in the plasma interior

Diffusive flux of energy in binary mixtures

International Nuclear Information System (INIS)

Sampaio, R.S.

1976-04-01

The diffusive flux of energy j tilde is studied through the reduced diffusive flux of energy K tilde, which obeys equations of the form: sim(delta K tilde/delta grad rho sub(α))= sim(delta K tilde/delta grad theta)=0. By a representation theorem, herein proved, is obtained a general representation for K tilde which is simplified, for the case of binary mixtures, using the principle of objectivity. Some consequences of this representation are discussed such as the symmetry of the partial stresses T 1 tilde and T 2 tilde and the difference between the normal stresses [pt

The kinetics of oocyst shedding and sporulation in two immunologically distinct strains of Eimeria maxima, GS and M6.

Science.gov (United States)

Al-Badri, Riadh; Barta, John Robert

2012-11-01

The kinetics of oocyst shedding and sporulation of two immunologically distinct strains of Eimeria maxima (GS and M6) were compared. Both strains had a prepatent period of approximately 120 h followed by peak oocyst shedding at 144-150 h post inoculation. Mean total oocyst output determined for each strain demonstrated that the fecundity of the M6 strain (12.8 × 10(3) ± 1.95) of E. maxima was roughly twice that of the GS strain (6.9 × 10(3) ± 3.33) when inoculated at the rate of 1,000 infective oocysts per bird. The process of oocyst sporulation was followed by repetitive sampling of sporulating oocysts at 26 °C with aeration over a 138 hour period. Sporulation was divided into five morphologically distinguishable stages whose abundance peaked at the following times during sporulation: unsporulated oocysts at 0 h; sporoblast anlagen at 18 h; sporoblasts without sporocyst walls at 22 h; and sporocysts without mature sporozoites at 38 h. The time to 50 % sporulation of E. maxima oocysts observed in the present study was approximately 53 h for both strains and all viable oocysts had completed sporulation by 60 h. In the present study, the prepatent periods, duration of oocyst shedding, and the relative kinetics of sporulation of the GS and M6 strains of E. maxima were found to be virtually identical despite the immunological distinctiveness of these two parasite strains.

Development of feed supplement Urea Molasses Multi nutrient Block (UMMB) using protein source from soy bean flour and gliricidia sepium (Gs) for ruminant animal

International Nuclear Information System (INIS)

Suharyono

2014-01-01

The aim of this activities is to develop formula of feed supplement UMMB-Gs for ruminant animal. The development of feed supplement was carried out on a laboratory and field scale. The activities on laboratory scale include biological evaluation of feed supplement used isotope technique P-32 in order to measure ratio bacteria and protozoa and growth rate of microbial cell in rumen liquid by in vitro studies. Two feed supplement were developed, these were UMMB-TK and UMMB-Gs. Two UMMB-TK were produced at pesantren Al Hikmah and Famor Satwa. Gliricidia sepium meal combined with UMMB-BK were tested on Goat of PE, buffaloes and beef cattle by in vitro studies in order to measure growth rate of microbial cell in rumen liquid using P-32. On the next activity the effect of UMMB-Gs on production and fat concentration of milk from dairy cattle was done. Statistical analysis used were test, 3x3 latin square design and randomize block design respectively. Quality control of UMMB indicated that ratio of bacteria and protozoa was 14 : 1 on UMMB-BK formulas, whereas on UMMB-TK1 it was found 19 : 1 and UMMB-TK2 was 17 : 1 respectively. These results were better then control (grass only). The value of feed control was 1 : 4. The result of UMMB-BK combinated with Gs on laboratory scale was capable of increasing growth rate of microbial cell on rumen liquid of Goat PE, buffaloes and beef cattle. The values were 102.01%; 205.7% and 73.7% respectively compared to control. Field trial of UMMB-Gs increased milk production and fat concentration on dairy cattle. It mean that nuclear technique has a potential role on the finding of a new feed supplement formulas and capable of giving positive impact, when UMMB feed supplement was able to create job field for small business of UMMB product based on local feed resources. (author)

Genome Sequence of Aeribacillus pallidus Strain GS3372, an Endospore-Forming Bacterium Isolated in a Deep Geothermal Reservoir

OpenAIRE

Sevasti Filippidou; Marion Jaussi; Thomas Junier; Tina Wunderlin; Nicole Jeanneret; Simona Regenspurg; Po-E Li; Chien-Chi Lo; Shannon Johnson; Kim McMurry; Cheryl D. Gleasner; Momchilo Vuyisich; Patrick S. Chain; Pilar Junier

2015-01-01

The genome of strain GS3372 is the first publicly available strain of Aeribacillus pallidus. This endospore-forming thermophilic strain was isolated from a deep geothermal reservoir. The availability of this genome can contribute to the clarification of the taxonomy of the closely related Anoxybacillus, Geobacillus, and Aeribacillus genera.

Lithium pellet injection experiments on the Alcator C-Mod tokamak

Energy Technology Data Exchange (ETDEWEB)

Garnier, Darren Thomas [Univ. of California, Berkeley, CA (United States)

1996-06-01

A pellet enhanced performance mode, showing significantly reduced core transport, is regularly obtained after the injection of deeply penetrating lithium pellets into Alcator C-Mod discharges. These transient modes, which typically persist about two energy confinement times, are characterized by a steep pressure gradient (ℓ_p ℓ a/5) in the inner third of the plasma, indicating the presence of an internal transport barrier. Inside this barrier, particle and energy diffusivities are greatly reduced, with ion thermal diffusivity dropping to near neoclassical values. Meanwhile, the global energy confinement time shows a 30% improvement over ITER89-P L-mode scaling. The addition of ICRF auxiliary heating shortly after the pellet injection leads to high fusion reactivity with neutron rates enhanced by an order of magnitude over L-mode discharges with similar input powers. A diagnostic system for measuring equilibrium current density profiles of tokamak plasmas, employing high speed lithium pellets, is also presented. Because ions are confined to move along field lines, imaging the Li⁺ emission from the toroidally extended pellet ablation cloud gives the direction of the magnetic field. To convert from temporal to radial measurements, the 3-D trajectory of the pellet is determined using a stereoscopic tracking system. These measurements, along with external magnetic measurements, are used to solve the Grad-Shafranov equation for the magnetic equilibrium of the plasma. This diagnostic is used to determine the current density profile of PEP modes by injection of a second pellet during the period of good confinement. This measurement indicates that a region of reversed magnetic shear exists at the plasma core. This current density profile is consistent with TRANSP calculations for the bootstrap current created by the pressure gradient. MHD stability analysis indicates that these plasmas are near the n = ∞ and the n = 1 marginal stability limits.

Lithium pellet injection experiments on the Alcator C-Mod tokamak

International Nuclear Information System (INIS)

Garnier, D.T.

1996-06-01

A pellet enhanced performance mode, showing significantly reduced core transport, is regularly obtained after the injection of deeply penetrating lithium pellets into Alcator C-Mod discharges. These transient modes, which typically persist about two energy confinement times, are characterized by a steep pressure gradient (ell p ≤ a/5) in the inner third of the plasma, indicating the presence of an internal transport barrier. Inside this barrier, particle and energy diffusivities are greatly reduced, with ion thermal diffusivity dropping to near neoclassical values. Meanwhile, the global energy confinement time shows a 30% improvement over ITER89-P L-mode scaling. The addition of ICRF auxiliary heating shortly after the pellet injection leads to high fusion reactivity with neutron rates enhanced by an order of magnitude over L-mode discharges with similar input powers. A diagnostic system for measuring equilibrium current density profiles of tokamak plasmas, employing high speed lithium pellets, is also presented. Because ions are confined to move along field lines, imaging the Li + emission from the toroidally extended pellet ablation cloud gives the direction of the magnetic field. To convert from temporal to radial measurements, the 3-D trajectory of the pellet is determined using a stereoscopic tracking system. These measurements, along with external magnetic measurements, are used to solve the Grad-Shafranov equation for the magnetic equilibrium of the plasma. This diagnostic is used to determine the current density profile of PEP modes by injection of a second pellet during the period of good confinement. This measurement indicates that a region of reversed magnetic shear exists at the plasma core. This current density profile is consistent with TRANSP calculations for the bootstrap current created by the pressure gradient. MHD stability analysis indicates that these plasmas are near the n = ∞ and the n = 1 marginal stability limits

Measurement of internal magnetic field pitch using Li pellet injection on TFTR (invited)

International Nuclear Information System (INIS)

Terry, J.L.; Marmar, E.S.; Howell, R.B.; Bell, M.; Cavallo, A.; Fredrickson, E.; Ramsey, A.; Schmidt, G.L.; Stratton, B.; Taylor, G.; Mauel, M.E.

1990-01-01

A diagnostic technique which measures the direction of the internal magnetic field pitch angle has been used successfully on TFTR. The technique requires the injection of high-speed Li pellets. The magnetic field direction is measured by observing the polarization direction of the intense visible line emission from Li + (λ∼5485 A, 1s2p 3 P 0,1,2 →1s2s 3 S 0 ) in the pellet ablation cloud. The presence of the large (primarily toroidal) magnetic field causes the line to be split due to the Zeeman effect, and the unshifted π component is polarized with its polarization direction parallel to the local magnetic field. In devices with sufficiently strong fields (B approx-gt 4.5 T), the Zeeman splitting of the line is large enough, relative to the linewidth of each Zeeman component, that enough residual polarization remains. Because the pellet moves about 1 cm before the Li + is ionized (τ ionization approx-lt 10 μs), the time history of the polarization direction (as the pellet penetrates from the outside toward the plasma center) yields the local magnetic field direction. In the TFTR experiment, spatial resolution of the measurement is typically ∼7 cm, limited by the requirement that a large number of photons must be collected in order to make the measurement of the polarization angle. Typically, the pitch of the field is measured with an accuracy of ±0.01 rad, limited by the photon statistics. The measurements of the internal field pitch angle, combined with external magnetic measurements, have been used in a code which finds the solution of the Grad--Shafranov equation, yielding the equilibrium which is the best fit to the measured inputs

Replacement of a cracked pressure tube in Bruce GS unit 2

International Nuclear Information System (INIS)

Dunn, J.T.

1982-06-01

In 1982 February, a primary heat transport system leak was detected in the annulus gas system by on-line instrumentation. The source of the leak was found to be a small axial crack in the pressure tube of fuel channel X-14. This fuel channel was removed and replaced by station maintenance staff, and the unit was returned to service five weeks after it had been shut down. The cracked pressure tube was sent to Chalk River Nuclear Laboratories for examination, and the crack was found to be very similar to those found in Pickering GS units 3 and 4 in 1974-75. It was caused by delayed hydride cracking during the period of high residual stress between the time of rolling and the pre-service stress relief

Radiation degradation of α-substituted acrylate polymers and copolymers

International Nuclear Information System (INIS)

Helbert, J.N.; Caplan, P.J.; Poindexter, E.H.

1977-01-01

Radiation degradation is observed in poly(methyl α-chloroacrylate), poly(methyl α-cyanoacrylate), and poly (α-chloroacrylonitrile) homopolymers and their respective MMA copolymers when γ-irradiated in vacuo. Polymer degradation susceptibilities are quantified in terms of G(scission radicals) and G(scission) -- G(crosslinks), measured by EPR and membrane osmometry, respectively; values by these two methods are compared. Higher G(rads) values ranging from 2 to 6 and [G(s) -- G(x)] values ranging from 2 to 11 are obtained for the substituted polymers and copolymers relative to the values for PMMA (1.6; 1.9), a standard e-beam positive resist, which suggests that these modified polymers are more sensitive e-beam resists than PMMA

Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics

NARCIS (Netherlands)

Gautier, Violette|info:eu-repo/dai/nl/372660851; Boumeester, Anja J.; Lössl, Philip|info:eu-repo/dai/nl/371559693; Heck, Albert J R|info:eu-repo/dai/nl/105189332

2015-01-01

Antibody-drug conjugates (ADCs) are a novel class of biopharmaceuticals several of which are now being investigated in clinical studies. In ADCs, potent cytotoxic drugs are coupled via a linker to reactive residues in IgG monoclonal antibodies. Linkage to lysine residues in the IgGs, using

Quarter-Sweep Iteration Concept on Conjugate Gradient Normal Residual Method via Second Order Quadrature - Finite Difference Schemes for Solving Fredholm Integro-Differential Equations

International Nuclear Information System (INIS)

Aruchunan, E.

2015-01-01

In this paper, we have examined the effectiveness of the quarter-sweep iteration concept on conjugate gradient normal residual (CGNR) iterative method by using composite Simpson's (CS) and finite difference (FD) discretization schemes in solving Fredholm integro-differential equations. For comparison purposes, Gauss- Seidel (GS) and the standard or full- and half-sweep CGNR methods namely FSCGNR and HSCGNR are also presented. To validate the efficacy of the proposed method, several analyses were carried out such as computational complexity and percentage reduction on the proposed and existing methods. (author)

Genome Sequence of Aeribacillus pallidus Strain GS3372, an Endospore-Forming Bacterium Isolated in a Deep Geothermal Reservoir.

Science.gov (United States)

Filippidou, Sevasti; Jaussi, Marion; Junier, Thomas; Wunderlin, Tina; Jeanneret, Nicole; Regenspurg, Simona; Li, Po-E; Lo, Chien-Chi; Johnson, Shannon; McMurry, Kim; Gleasner, Cheryl D; Vuyisich, Momchilo; Chain, Patrick S; Junier, Pilar

2015-08-27

The genome of strain GS3372 is the first publicly available strain of Aeribacillus pallidus. This endospore-forming thermophilic strain was isolated from a deep geothermal reservoir. The availability of this genome can contribute to the clarification of the taxonomy of the closely related Anoxybacillus, Geobacillus, and Aeribacillus genera. Copyright © 2015 Filippidou et al.

A combined coalescence gene-dropping tool for evaluating genomic selection in complex scenarios (ms2gs).

Science.gov (United States)

Pérez-Enciso, M; Legarra, A

2016-04-01

We present ms2gs, a combined coalescence - gene dropping (i.e. backward-forward) simulator for complex traits. It therefore aims at combining the advantages of both approaches. It is primarily conceived for very short term, recent scenarios such as those that are of interest in animal and plant breeding. It is very flexible in terms of defining QTL architecture and SNP ascertainment bias, and it allows for easy modelling of alternative markers such as RADs. It can use real sequence or chip data or generate molecular polymorphisms via the coalescence. It can generate QTL conditional on extant molecular information, such as low-density genotyping. It models (simplistically) sequence, imputation or genotyping errors. It requires as input both genotypic data in plink or ms formats, and a pedigree that is used to perform the gene dropping. By default, it compares accuracy for BLUP, SNP ascertained data, sequence, and causal SNPs. It employs VanRaden's linear (GBLUP) and nonlinear method for incorporating molecular information. To illustrate the program, we present a small application in a half-sib population and a multiparental (MAGIC) cross. The program, manual and examples are available at https://github.com/mperezenciso/ms2gs. © 2016 Blackwell Verlag GmbH.

Behind the scenes of GS: Did you say “grey”?

CERN Multimedia

Antonella Del Rosso

2014-01-01

Walking around the CERN site, what we tend to notice are the buildings, roads, and car parks. At first glance, any “green” seems to be in the minority. The reality is quite different, as developed land takes up only 40 of the almost 650 hectares made available to the Organization by its Host States.   1,300 trees in CERN's enclosed areas, 250 hectares of cultivated fields and meadows, 140 hectares of woodland, and three wetlands: CERN clearly deserves its “green” certification from the Swiss conservation foundation Nature et économie that it has held since 2009. "We maintain every site, but each site is different and has its own conservation criteria," says Mathieu Fontaine, head of Green Spaces in the Civil Engineering and Buildings section of the GS Department. At CERN, an external company takes care of the day-to-day upkeep, but more complex operations are often necessary. The various projects to fell diseased or ...

PI3Kδ inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kδ and BTK inhibitors.

Directory of Open Access Journals (Sweden)

Anella Yahiaoui

Full Text Available Activated B-cell-like diffuse large B-cell lymphoma relies on B-cell receptor signaling to drive proliferation and survival. Downstream of the B-cell receptor, the key signaling kinases Bruton's tyrosine kinase and phosphoinositide 3-kinase δ offer opportunities for therapeutic intervention by agents such as ibrutinib, ONO/GS-4059, and idelalisib. Combination therapy with such targeted agents could provide enhanced efficacy due to complimentary mechanisms of action. In this study, we describe both the additive interaction of and resistance mechanisms to idelalisib and ONO/GS-4059 in a model of activated B-cell-like diffuse large B-cell lymphoma. Significant tumor regression was observed with a combination of PI3Kδ and Bruton's tyrosine kinase inhibitors in the mouse TMD8 xenograft. Acquired resistance to idelalisib in the TMD8 cell line occurred by loss of phosphatase and tensin homolog and phosphoinositide 3-kinase pathway upregulation, but not by mutation of PIK3CD. Sensitivity to idelalisib could be restored by combining idelalisib and ONO/GS-4059. Further evaluation of targeted inhibitors revealed that the combination of idelalisib and the phosphoinositide-dependent kinase-1 inhibitor GSK2334470 or the AKT inhibitor MK-2206 could partially overcome resistance. Characterization of acquired Bruton's tyrosine kinase inhibitor resistance revealed a novel tumor necrosis factor alpha induced protein 3 mutation (TNFAIP3 Q143*, which led to a loss of A20 protein, and increased p-IκBα. The combination of idelalisib and ONO/GS-4059 partially restored sensitivity in this resistant line. Additionally, a mutation in Bruton's tyrosine kinase at C481F was identified as a mechanism of resistance. The combination activity observed with idelalisib and ONO/GS-4059, taken together with the ability to overcome resistance, could lead to a new therapeutic option in activated B-cell-like diffuse large B-cell lymphoma. A clinical trial is currently underway to

Regularization of Grad’s 13 -Moment-Equations in Kinetic Gas Theory

Science.gov (United States)

2011-01-01

Aji ) − 13Akkδij . Beside the angular brackets normal brackets are used to abbreviate the normalized sum of index-permutated tensor expressions, i.e...A(ij) = 1 2 (Aij + Aji ). An introduction to tensorial operations also on higher order tensors can be find in Struchtrup (2005b). The stress tensor...vary only across the channel, that is, the coordinate y. The red dots indicate schematically what behavior for the fields must be expected. For

Stability Results, Almost Global Generalized Beltrami Fields and Applications to Vortex Structures in the Euler Equations

Science.gov (United States)

Enciso, Alberto; Poyato, David; Soler, Juan

2018-05-01

Strong Beltrami fields, that is, vector fields in three dimensions whose curl is the product of the field itself by a constant factor, have long played a key role in fluid mechanics and magnetohydrodynamics. In particular, they are the kind of stationary solutions of the Euler equations where one has been able to show the existence of vortex structures (vortex tubes and vortex lines) of arbitrarily complicated topology. On the contrary, there are very few results about the existence of generalized Beltrami fields, that is, divergence-free fields whose curl is the field times a non-constant function. In fact, generalized Beltrami fields (which are also stationary solutions to the Euler equations) have been recently shown to be rare, in the sense that for "most" proportionality factors there are no nontrivial Beltrami fields of high enough regularity (e.g., of class {C^{6,α}}), not even locally. Our objective in this work is to show that, nevertheless, there are "many" Beltrami fields with non-constant factor, even realizing arbitrarily complicated vortex structures. This fact is relevant in the study of turbulent configurations. The core results are an "almost global" stability theorem for strong Beltrami fields, which ensures that a global strong Beltrami field with suitable decay at infinity can be perturbed to get "many" Beltrami fields with non-constant factor of arbitrarily high regularity and defined in the exterior of an arbitrarily small ball, and a "local" stability theorem for generalized Beltrami fields, which is an analogous perturbative result which is valid for any kind of Beltrami field (not just with a constant factor) but only applies to small enough domains. The proof relies on an iterative scheme of Grad-Rubin type. For this purpose, we study the Neumann problem for the inhomogeneous Beltrami equation in exterior domains via a boundary integral equation method and we obtain Hölder estimates, a sharp decay at infinity and some compactness

Rhipicephalus microplus dataset of nonredundant raw sequence reads from 454 GS FLX sequencing of Cot-selected (Cot = 660) genomic DNA

Science.gov (United States)

A reassociation kinetics-based approach was used to reduce the complexity of genomic DNA from the Deutsch laboratory strain of the cattle tick, Rhipicephalus microplus, to facilitate genome sequencing. Selected genomic DNA (Cot value = 660) was sequenced using 454 GS FLX technology, resulting in 356...

RELACION DE LA EXPRESION DEL RECEPTOR DE INSULINA CON LA EXPRESION DE LAS ENZIMAS GLICOGENICAS (GS1 Y GS2) Y GLUCONEOGENICAS EN LAS CELULAS DE TUBULO PROXIMAL DE RATAS NORMALES Y DIABETICAS

OpenAIRE

GATICA GUTIERREZ, RODRIGO ORLANDO; GATICA GUTIERREZ, RODRIGO ORLANDO

2012-01-01

En el presente estudio se determinó los efectos sobre la expresión y localización del receptor de insulina (InsR), de glicógeno sin tasa (GS) y de las enzimas glicolíticas y gluconeogénicas en diabetes de largo plazo. Insulina es esencial para el manejo energético del cuerpo, sin embargo, su rol a nivel renal es poco conocido. Su unión al receptor de insulina provoca una cascada de señalización intracelular, que regula múltiples procesos biológicos, tales corno el metabolismo lipídico y pr...

MHD-model for low-frequency waves in a tokamak with toroidal plasma rotation and problem of existence of global geodesic acoustic modes

Energy Technology Data Exchange (ETDEWEB)

Lakhin, V. P.; Sorokina, E. A., E-mail: sorokina.ekaterina@gmail.com, E-mail: vilkiae@gmail.com; Ilgisonis, V. I. [National Research Centre Kurchatov Institute (Russian Federation); Konovaltseva, L. V. [Peoples’ Friendship University of Russia (Russian Federation)

2015-12-15

A set of reduced linear equations for the description of low-frequency perturbations in toroidally rotating plasma in axisymmetric tokamak is derived in the framework of ideal magnetohydrodynamics. The model suitable for the study of global geodesic acoustic modes (GGAMs) is designed. An example of the use of the developed model for derivation of the integral conditions for GGAM existence and of the corresponding dispersion relation is presented. The paper is dedicated to the memory of academician V.D. Shafranov.

Development of a 1 GS/s high-resolution transient recorder

CERN Document Server

Bartknecht, S; Herrmann, F; Königsmann, K; Lauser, L; Schill, C; Schopferer, S; Wollny, H

2009-01-01

With present-day detectors in high energy physics one is often faced with short analog pulses of a few nanoseconds length which may cover large dynamic ranges. In many experiments both amplitude and timing information have to be measured with high accuracy. Additionally, the data rate per readout channel can reach several MHz, which makes high demands on the separation of pile-up pulses. For such applications we have built the GANDALF transient recorder with a resolution of 12bit@1GS/s and an analog bandwidth of 500 MHz. Signals are digitized and processed by fast algorithms to extract pulse arrival times and amplitudes in real-time and to generate experiment trigger signals. With up to 16 analog channels, deep memories and a high data rate interface, this 6U-VME64x/VXS module is not only a dead-time free digitization unit but also has huge numerical capabilities provided by the implementation of a Virtex5-SXT FPGA. Fast algorithms implemented in the FPGA may be used to disentangle possible pile-up pulses and...

Impact of error fields on equilibrium configurations in ITER

Energy Technology Data Exchange (ETDEWEB)

Barbato, Lucio [DIEI, Università di Cassino and Lazio Meridionale, Cassino (Italy); Formisano, Alessandro, E-mail: alessandro.formisano@unina2.it [Department of Industrial and Information Engineering, Seconda Univ. di Napoli, Aversa (Italy); Martone, Raffaele [Department of Industrial and Information Engineering, Seconda Univ. di Napoli, Aversa (Italy); Villone, Fabio [DIEI, Università di Cassino and Lazio Meridionale, Cassino (Italy)

2015-10-15

Highlights: • Error fields (EF) are discrepancies from nominal magnetic field, and may alter plasma behaviour. • They are due to, e.g., coils manufacturing and assembly errors. • EF impact in ITER equilibria is analyzed using numerical simulations. • A high accuracy 3D field computation module and a Grad-Shafranov solver are used. • Deformations size allow using a linearized model, and performing a sensitivity analysis. - Abstract: Discrepancies between design and actual magnetic field maps in tokamaks are unavoidable, and are associated to a number of causes, e.g. manufacturing and assembly tolerances on magnets, presence of feeders and joints, non-symmetric iron parts. Such error fields may drive plasma to loss of stability, and must be carefully controlled using suitable correction coils. Anyway, even when kept below safety threshold, error fields may alter the behavior of plasma. The present paper, using as example the error fields induced by tolerances in toroidal field coils, quantifies their effect on the plasma boundary shape in equilibrium configurations. In particular, a procedure able to compute the shape perturbations due to given deformations of the coils has been set up and used to carry out a thorough statistical analysis of the error field-shape perturbations relationship.

Carbon steel protection in G.S. [Girldler sulphide] plants: Pt. 7

International Nuclear Information System (INIS)

Lires, Osvaldo; Delfino, Cristina; Rojo, Enrique.

1989-01-01

In order to protect carbon steel towers and piping of a GS experimental heavy water plant against corrosion produced by the action of aqueous solutions of hydrogen sulphide, a method, elsewhere published, was developed. Carbon steel exposed to saturated aqueous solutions of hydrogen sulphide forms iron sulphide scales. In oxygen free solutions, evolution of corrosion follows the sequence mackinawite → cubic ferrous sulphide → troilite → pyrrotite → pyrite. Scales formed by pyrrotite and pyrite are the most protective layers (these are obtained at 130 deg C, 2 MPa for a period of 14 days). During a plant shutdown procedures, the carbon steel protected with those scales is exposed to water and highly humid air; under such conditions oxidation is unavoidable. Later, treatment in plant conditions does not regenerate scales because the composition of regenerated scales involves more soluble iron sulphides such as mackinawite and troilite. Therefore, it is not recommendable to expose the protective scales to atmospherical conditions. (Author)

Carbon steel protection in G.S. [Girldler sulphide] plants: Pt. 8

International Nuclear Information System (INIS)

Lires, Osvaldo; Delfino, Cristina; Rojo, Enrique.

1990-01-01

In order to protect carbon steel of towers and piping of a GS experimental heavy water plant against corrosion produced by the action of aqueous solutions of hydrogen sulphide, a method, elsewhere published, was developed. Carbon steel exposed to saturated aqueous solutions of hydrogen sulphide forms iron sulphide scales. In oxygen free solutions, evolution of corrosion follows the sequence mackinawate → cubic ferrous sulphide → troilite → pyrrotite → pyrite. Scales formed by pyrrotite and pyrite are the most protective layers (these are obtained at 130 deg C, 2 MPa for a period of 14 days). Pyrite formation is favoured by an oxidizing agent presence that allows the oxidation of sulphur ions to disulphur ions. Elemental sulphur or oxygen were used as oxidating agents. Variation and operational parameters such as concentration, temperature, pH, aggregate time, etc. were studied. Though little improvement on protective scales quality was observed, results do not justify operational troubles and the additional costs and effort involved. (Author)

A 6-bit 4 GS/s pseudo-thermometer segmented CMOS DAC

Science.gov (United States)

Yijun, Song; Wenyuan, Li

2014-06-01

A 6-bit 4 GS/s, high-speed and power-efficient DAC for ultra-high-speed transceivers in 60 GHz band millimeter wave technology is presented. A novel pseudo-thermometer architecture is proposed to realize a good compromise between the fast conversion speed and the chip area. Symmetrical and compact floor planning and layout techniques including tree-like routing, cross-quading and common-centroid method are adopted to guarantee the chip is fully functional up to near-Nyquist frequency in a standard 0.18 μm CMOS process. Post simulation results corroborate the feasibility of the designed DAC, which canperform good static and dynamic linearity without calibration. DNL errors and INL errors can be controlled within ±0.28 LSB and ±0.26 LSB, respectively. SFDR at 4 GHz clock frequency for a 1.9 GHz near-Nyquist sinusoidal output signal is 40.83 dB and the power dissipation is less than 37 mW.

A 6-bit 4 GS/s pseudo-thermometer segmented CMOS DAC

International Nuclear Information System (INIS)

Song Yijun; Li Wenyuan

2014-01-01

A 6-bit 4 GS/s, high-speed and power-efficient DAC for ultra-high-speed transceivers in 60 GHz band millimeter wave technology is presented. A novel pseudo-thermometer architecture is proposed to realize a good compromise between the fast conversion speed and the chip area. Symmetrical and compact floor planning and layout techniques including tree-like routing, cross-quading and common-centroid method are adopted to guarantee the chip is fully functional up to near-Nyquist frequency in a standard 0.18 μm CMOS process. Post simulation results corroborate the feasibility of the designed DAC, which canperform good static and dynamic linearity without calibration. DNL errors and INL errors can be controlled within ±0.28 LSB and ±0.26 LSB, respectively. SFDR at 4 GHz clock frequency for a 1.9 GHz near-Nyquist sinusoidal output signal is 40.83 dB and the power dissipation is less than 37 mW. (semiconductor integrated circuits)

Intraesophageal administratio (JP4-039) and p53/MDM2/MDM4 Inhibitor (BEB55) ameliorates radiation esophagitisn of GS-Nitroxide

NARCIS (Netherlands)

Kim, H.; Bernard, M.; Epperly, M.W.; Shen, H.; Dixon, T.M.; Amoscato, A.A.; Doemling, A.S.; Li, S.; Gao, X.; Wipf, P.

2011-01-01

Purpose/Objective(s): To evaluate the esophageal radiation dose modification properties of the GS-nitroxide (JP4-039) and the p53/MDM2/MDM4 inhibitor (BEB55). Materials/Methods: Esophagitis is a significant toxicity of radiation therapy of thoracic cancers. We evaluated radiation dose modification

Studies on silicone based antifoaming agents to be used in G.S. (Girlder sulfide) heavy water plants

International Nuclear Information System (INIS)

Delfino, C.A.

1986-01-01

In Girlder sulfide (G.S.) heavy water plants hydrogen sulfide-water systems are inherentely foaming, so the adding of antifoaming materials is of great importance. These may be of high volatility, pyrolizable or chemically unstable in plant operation conditions (water and hydrogen sulfide at 2MPa, up to 230 deg C). Six commercial silicone based antifoaming agents were studied from the point of view of their chemical and thermical stability in order to select the most suitable. (Author) [es

Antifoaming materials studies in G.S. (Girlder sulfide) heavy water plants. Chemical and thermical stability. Pt. 3

International Nuclear Information System (INIS)

Delfino, C.A.; Rojo, E.A.

1988-01-01

In Girlder sulfide (G.S.) heavy water plants hydrogen sulfide-water systems are inherentely foaming, so the adding of antifoaming materials is of great importance. These may be of high volatility, pyrolizable or chemically unstable in plant operation conditions (water and hydrogen sulfide at 2 MPa, up to 230 deg C). Five commercial surfactants were studied from the point of view of their chemical and thermical stability in order to select the most suitable. (Author) [es

B(IS4;0GS+→4γ+) systematics in rare-earth nuclei: SU sdg (3) description

International Nuclear Information System (INIS)

Devi, Y.D.; Kota, V.K.B.

1993-01-01

The observed variation of B(IS4; 0 GS + →4 γ + ) with mass number A, that gives information about hexadecupole component in γ-vibration, in rare-earth nuclei is studied in the SU sdg (3) limit of sdg interacting boson model empoloying IBM-2 to IBM-1 projected hexadecupole transition operator with effective charges determined using a multi-j shell mapping procedure. The SU sdg (3) limit provides a reasonably good description of the data. (orig.)

Reseña: Abal Oliú, Alejandro: C.G.P. y conciliación previa en materia laboral, Editorial Universidad Ltda. Montevideo, 1992, 64 págs.

Directory of Open Access Journals (Sweden)

o. C. R.

2015-10-01

Full Text Available Abal Oliú, Alejandro: C.G.P. y conciliación previa en materia laboral, Editorial Universidad Ltda. Montevideo, 1992, 64 págs. Editorial Universidad Ltda. Montevideo, 1992, 64 págs.El autor, profesor de Derecho Procesal y de Técnica Forense en nuestra Facultad, analiza en la presente obra las distintas fórmulas que es posible estab~ecer en cuanto a la tentativa de conciliación previa a la iniciación de los procesos laborales, luego de la entrada en vigencia del Código General del Proceso. (...

The Vigna Genome Server, 'VigGS': A Genomic Knowledge Base of the Genus Vigna Based on High-Quality, Annotated Genome Sequence of the Azuki Bean, Vigna angularis (Willd.) Ohwi & Ohashi.

Science.gov (United States)

Sakai, Hiroaki; Naito, Ken; Takahashi, Yu; Sato, Toshiyuki; Yamamoto, Toshiya; Muto, Isamu; Itoh, Takeshi; Tomooka, Norihiko

2016-01-01

The genus Vigna includes legume crops such as cowpea, mungbean and azuki bean, as well as >100 wild species. A number of the wild species are highly tolerant to severe environmental conditions including high-salinity, acid or alkaline soil; drought; flooding; and pests and diseases. These features of the genus Vigna make it a good target for investigation of genetic diversity in adaptation to stressful environments; however, a lack of genomic information has hindered such research in this genus. Here, we present a genome database of the genus Vigna, Vigna Genome Server ('VigGS', http://viggs.dna.affrc.go.jp), based on the recently sequenced azuki bean genome, which incorporates annotated exon-intron structures, along with evidence for transcripts and proteins, visualized in GBrowse. VigGS also facilitates user construction of multiple alignments between azuki bean genes and those of six related dicot species. In addition, the database displays sequence polymorphisms between azuki bean and its wild relatives and enables users to design primer sequences targeting any variant site. VigGS offers a simple keyword search in addition to sequence similarity searches using BLAST and BLAT. To incorporate up to date genomic information, VigGS automatically receives newly deposited mRNA sequences of pre-set species from the public database once a week. Users can refer to not only gene structures mapped on the azuki bean genome on GBrowse but also relevant literature of the genes. VigGS will contribute to genomic research into plant biotic and abiotic stresses and to the future development of new stress-tolerant crops. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Follicular variant of papillary thyroid carcinoma presenting as toxic nodule in an adolescent: coexistent polymorphism of the TSHR and Gsα genes.

Science.gov (United States)

Ruggeri, Rosaria Maddalena; Campennì, Alfredo; Giovinazzo, Salvatore; Saraceno, Giovanna; Vicchio, Teresa Manuela; Carlotta, Dario; Cucinotta, Maria Paola; Micali, Carmelo; Trimarchi, Francesco; Tuccari, Giovanni; Baldari, Sergio; Benvenga, Salvatore

2013-02-01

Autonomously functioning, "hot", thyroid nodules are not common in children and adolescents. Such nodules are not considered alarming because they are assumed to be benign adenomas. Herein, we present a 15-year-old girl with a papillary thyroid carcinoma of 3.5 cm in diameter, which was functionally autonomous and scintigraphically hot. The patient, initially referred to our Endocrine Unit because of a thyroid nodule, returned 6 months later for symptoms of hyperthyroidism. Hyperthyroidism was confirmed biochemically. Radioactive iodine ((131)I) thyroid scintigraphy was consistent with an autonomous thyroid nodule. As per guidelines, the patient underwent surgery and a pathological examination revealed papillary carcinoma, follicular variant. The excised nodule was examined for activating mutations of the thyrotropin receptor (TSHR), Gsα (GNAS1), H-RAS, N-RAS, K-RAS, and BRAF genes by direct sequencing. No mutations were found. Nevertheless, two combined nonfunctioning mutations were detected: a single-nucleotide polymorphism (SNP) of the TSHR gene, in exon 7, at codon 187 (AAT→AAC, both encoding asparagine), and a SNP within exon 8 of the Gsα gene at codon 185 (ATC→ATT, both encoding isoleucine). Both SNPs were also identified in the germline DNA of the patient. The same SNPs were sought in the parents and brother of our patient. Her father was heterozygous for the TSHR SNP, her mother heterozygous for the Gsα SNP, and her brother was wild type. This case demonstrates that the presence of hyperfunctioning thyroid nodule(s) does not rule out cancer and warrants careful evaluation, especially in childhood and adolescence to overlook malignancy.

Glutamine synthetase and alanine transaminase expression are decreased in livers of aged vs. young beef cows and GS can be upregulated by 17β-estradiol implants.

Science.gov (United States)

Miles, E D; McBride, B W; Jia, Y; Liao, S F; Boling, J A; Bridges, P J; Matthews, J C

2015-09-01

Aged beef cows (≥ 8 yr of age) produce calves with lower birth and weaning weights. In mammals, aging is associated with reduced hepatic expression of glutamine synthetase (GS) and alanine transaminase (ALT), thus impaired hepatic Gln-Glu cycle function. To determine if the relative protein content of GS, ALT, aspartate transaminase (AST), glutamate transporters (EAAC1, GLT-1), and their regulating protein (GTRAP3-18) differed in biopsied liver tissue of (a) aged vs. young (3 to 4 yr old) nonlactating, nongestating Angus cows (Exp. 1 and 2) and (b) aged mixed-breed cows with and without COMPUDOSE (17β-estradiol) ear implants (Exp. 3), Western blot analyses were performed. In Exp. 1, 12 young (3.62 ± 0.01 yr) and 13 aged (10.08 ± 0.42 yr) cows grazed the same mixed forage for 42 d (August-October). In Exp. 2, 12 young (3.36 ± 0.01 yr) and 12 aged (10.38 ± 0.47 yr) cows were individually fed (1.03% of BW) a corn-silage-based diet to maintain BW for 20 d. For both Exp. 1 and 2, the effect of cow age was assessed by ANOVA using the MIXED procedure of SAS. Cow BW did not change ( ≥ 0.17). Hepatic ALT (78% and 61%) and GS (52% and 71%) protein content (Exp. 1 and 2, respectively) was decreased ( ≤ 0.01), whereas GTRAP3-18 (an inhibitor of EAAC1 activity) increased ( ≤ 0.01; 170% and 136%) and AST, GLT-1, and EAAC1 contents did not differ ( ≥ 0.17) in aged vs. young cows. In Exp. 2, free concentrations (nmol/g) of Glu, Ala, Gln, Arg, and Orn in liver homogenates were determined. Aged cows tended to have less ( = 0.10) free Gln (15.0%) than young cows, whereas other AA concentrations did not differ ( 0.26). In Exp. 3, 14 aged (> 10 yr) cows were randomly allotted ( = 7) to sham or COMPUDOSE (25.7 mg of 17β-estradiol) implant treatment (TRT), and had ad libitum access to alfalfa hay for 28 d. Blood and liver biopsies were collected 14 and 28 d after implant treatment. Treatment, time after implant (DAY), and TRT × DAY effects were assessed by ANOVA using

Enhancement of humoral immunity in mice by coupling pUCpGs10 and aluminium to the HCV recombinant immunogen

Directory of Open Access Journals (Sweden)

Zhan Na

2011-11-01

Full Text Available Abstract Aim To investigate the enhancement of humoral immunity when CpG ODN (cytidine phosphate guanosine oligodeoxynucleotides and aluminium adjuvants are complexed with the HCV (Hepatitis C virus recombinant immunogen in mice. Methods After immunizing Balb/c mice with the recombination HCV antigen adjuvanted with pUCpGs10 and/or aluminium(antigen+CpG+alum, antigen+CpG, antigen+alum, antigen+PBS, enzyme-linked immunosorbent assay (ELISA was used to measure the specific serum antibody titers of IgG, to determine the neutralization response to various peptide genotypes, and to determine the concentration of IL-6 and IL-10 in supernatants of in vitro cultured splenic lymphocytes. Enzyme-linked immunospot assay (ELISPOT was used to quantify the non-specific and specific splenic antibody-secreting cells (ASCs, and flow cytometry (FCM determined the ratio of different splenic lymphocytes. The serum of rabbits immunized with the recombinant pBVGST/HVR1 antigen immunoprecipitated the HCV isolated from 12 patients' serum. Results The sera antibody titers were 1:51200, 1:9051, 1:18102, 1:6400 respectively after the final immunization and demonstrated good neutralization responses to the six gene peptide containing 1a, 1b, 2a, 3a, 4a and 6a. The aluminum adjuvant increased the population of both specific ASCs (P +CD27+ (P +CD38+ splenic lymphocytes with the aluminum and pUCpGs10 adjuvant present compared to the control group(P Conclusions 1. The aluminum adjuvant induces a potent Th2-biased immune response by increasing both the populations of specific and total ASCs and the ratio of CD19+CD27+ cells. 2. The pUCpGs10 complexed with the aluminum adjuvant boosts the population of plasma cells and increase the efficiency of the immune response. 3. The two adjuvants have synergistic effects on humoral immunity. 4. The recombinant HVR1 protein has the possibility of generating broadly reactive anti-HVR1 antibody.

Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure

Directory of Open Access Journals (Sweden)

Paola Maccioni

2010-07-01

Full Text Available The present study was designed to evaluate (a alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases, and (b the effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in sP rats exposed to this procedure. To this end, sP rats were initially trained to lever-respond under a reinforcement requirement (RR 55 (RR55 for alcohol. Achievement of RR55 resulted in the 20-min presentation of the alcohol (15%, v/v-containing sipper bottle. Once stable levels of lever-responding and alcohol consumption were reached, rats were treated with 0, 25, 50, and 100 mg/kg GS39783 (i.g. 60 min before the self-administration session. Rats displayed robust alcohol-seeking (as suggested by relatively short latencies to the first lever-response and high frequencies of lever-responding and -taking (as suggested by alcohol intakes averaging approximately 1.5 g/kg behaviors. Pretreatment with GS39783 inhibited both alcohol-seeking (the number of rats achieving RR55 and the mean RR value were virtually halved and -taking (the amount of self-administered alcohol was reduced by approximately 60%. The results of the present study suggest the power of the “sipper” procedure in triggering high levels of alcohol-seeking and -taking behavior in sP rats. Further, these results extend to this additional procedure of alcohol self-administration the capacity of GS39783 to reduce the motivational properties of alcohol and alcohol consumption in sP rats.

Reduction by the Positive Allosteric Modulator of the GABAB Receptor, GS39783, of Alcohol Self-Administration in Sardinian Alcohol-Preferring Rats Exposed to the “Sipper” Procedure

Science.gov (United States)

Maccioni, Paola; Flore, Paolo; Carai, Mauro A. M.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; Gessa, Gian Luigi; Colombo, Giancarlo

2010-01-01

The present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases), and (b) the effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in sP rats exposed to this procedure. To this end, sP rats were initially trained to lever-respond under a reinforcement requirement (RR) 55 (RR55) for alcohol. Achievement of RR55 resulted in the 20-min presentation of the alcohol (15%, v/v)-containing sipper bottle. Once stable levels of lever-responding and alcohol consumption were reached, rats were treated with 0, 25, 50, and 100 mg/kg GS39783 (i.g.) 60 min before the self-administration session. Rats displayed robust alcohol-seeking (as suggested by relatively short latencies to the first lever-response and high frequencies of lever-responding) and -taking (as suggested by alcohol intakes averaging approximately 1.5 g/kg) behaviors. Pretreatment with GS39783 inhibited both alcohol-seeking (the number of rats achieving RR55 and the mean RR value were virtually halved) and -taking (the amount of self-administered alcohol was reduced by approximately 60%). The results of the present study suggest the power of the “sipper” procedure in triggering high levels of alcohol-seeking and -taking behavior in sP rats. Further, these results extend to this additional procedure of alcohol self-administration the capacity of GS39783 to reduce the motivational properties of alcohol and alcohol consumption in sP rats. PMID:21423431

Tokamak equilibria with non-parallel flow in a triangularity-deformed axisymmetric toroidal coordinate system

Directory of Open Access Journals (Sweden)

Ap Kuiroukidis

2018-01-01

Full Text Available We consider a generalized Grad–Shafranov equation (GGSE in a triangularity-deformed axisymmetric toroidal coordinate system and solve it numerically for the generic case of ITER-like and JET-like equilibria with non-parallel flow. It turns out that increase of the triangularity improves confinement by leading to larger values of the toroidal beta and the safety factor. This result is supported by the application of a criterion for linear stability valid for equilibria with flow parallel to the magnetic field. Also, the parallel flow has a weaker stabilizing effect.

Differential Equations Compatible with KZ Equations

International Nuclear Information System (INIS)

Felder, G.; Markov, Y.; Tarasov, V.; Varchenko, A.

2000-01-01

We define a system of 'dynamical' differential equations compatible with the KZ differential equations. The KZ differential equations are associated to a complex simple Lie algebra g. These are equations on a function of n complex variables z i taking values in the tensor product of n finite dimensional g-modules. The KZ equations depend on the 'dual' variable in the Cartan subalgebra of g. The dynamical differential equations are differential equations with respect to the dual variable. We prove that the standard hypergeometric solutions of the KZ equations also satisfy the dynamical equations. As an application we give a new determinant formula for the coordinates of a basis of hypergeometric solutions

Behind the scenes of GS: there’s only one way to go

CERN Multimedia

Anaïs Schaeffer

2014-01-01

At CERN, all of the Laboratory’s imports and exports are routed in the same way: through the Logistics Service. This GS-IS Group service is responsible for receiving, inspecting and distributing all goods sent to the Organization.   Whether products for the CERN Stores, components for the experiments, tools, machinery and materials for the workshops or equipment for users and members of the personnel, nothing escapes the attention of CERN’s Logistics Service, which every year processes nearly 70,000 incoming deliveries, 7,500 shipments and 160,000 distributed items. “The vast majority of our imports come from CERN Member States,” says imports and customs procedures manager Laurence Planque, “but we are receiving more and more goods for collaborators working at CERN from non-Member States such as China, India and Pakistan. All these imports are entitled to diplomatic exemption, so every day we have to manage the customs clearance procedures wit...

Integrability of Hamiltonian systems with homogeneous potentials of degree zero

Energy Technology Data Exchange (ETDEWEB)

Casale, Guy, E-mail: guy.casale@univ-rennes1.f [IRMAR UMR 6625, Universite de Rennes 1, Campus de Beaulieu, 35042 Rennes Cedex (France); Duval, Guillaume, E-mail: dduuvvaall@wanadoo.f [1 Chemin du Chateau, 76 430 Les Trois Pierres (France); Maciejewski, Andrzej J., E-mail: maciejka@astro.ia.uz.zgora.p [Institute of Astronomy, University of Zielona Gora, Licealna 9, PL-65-417 Zielona Gora (Poland); Przybylska, Maria, E-mail: Maria.Przybylska@astri.uni.torun.p [Torun Centre for Astronomy, N. Copernicus University, Gagarina 11, PL-87-100 Torun (Poland)

2010-01-04

We derive necessary conditions for integrability in the Liouville sense of classical Hamiltonian systems with homogeneous potentials of degree zero. We obtain these conditions through an analysis of the differential Galois group of variational equations along a particular solution generated by a non-zero solution d element of C{sup n} of nonlinear equation gradV(d)=d. We prove that when the system is integrable the Hessian matrix V{sup ''}(d) has only integer eigenvalues and is diagonalizable.

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

DEFF Research Database (Denmark)

Westfield, Gerwin H; Rasmussen, Søren Gøgsig Faarup; Su, Min

2011-01-01

The active-state complex between an agonist-bound receptor and a guanine nucleotide-free G protein represents the fundamental signaling assembly for the majority of hormone and neurotransmitter signaling. We applied single-particle electron microscopy (EM) analysis to examine the architecture...... of agonist-occupied β(2)-adrenoceptor (β(2)AR) in complex with the heterotrimeric G protein Gs (Gαsβγ). EM 2D averages and 3D reconstructions of the detergent-solubilized complex reveal an overall architecture that is in very good agreement with the crystal structure of the active-state ternary complex...

A comprehensive theory of the equilibria in a tokamak and a reversed field pinch

International Nuclear Information System (INIS)

Chiyoda, Katsuji

1996-01-01

The equilibrium configuration of a tokamak is analysed by the equilibrium equations derived for analysing a reversed field pinch (RFP). The expressions of the magnetic field and the toroidal shift in the internal plasma region and the external vacuum region are obtained. The expressions in the vacuum region become the Shafranov's expressions, when the plasma-center coordinates is used. Discontinuities of the equilibrium quantities are considered. It is concluded that the equilibrium equations are applicable also to the tokamak plasma and that the difference of the equilibria between the tokamak and the RFP stems from the choices of the pressure and the toroidal current function. A feature of our theory is that any ordering to the safety factor is not imposed. (author)

“Inclonals”: IgGs and IgG-enzyme fusion proteins produced in an E. coli expression-refolding system

OpenAIRE

Hakim, Rahely; Benhar, Itai

2009-01-01

Full-length antibodies and antibodies that ferry a cargo to target cells are desired biopharmaceuticals. We describe the production of full-length IgGs and IgG-toxin fusion proteins in E. coli. In the presented examples of anti CD30 and anti EGF-receptor antibodies, the antibody heavy and light chains or toxin fusions thereof were expressed in separate bacterial cultures, where they accumulated as insoluble inclusion bodies. Following refolding and purification, high yields (up to 50 mg/L of ...

New macroscopic theory of anamalous diffusion induced by the dissipative trapped-ion instability

International Nuclear Information System (INIS)

Wimmel, H.K.

1975-03-01

For an axisymmetric toroidal plasma of the TOKAMAK type a new set of dissipative trapped-fluid equations is established. In addition to E vector x B vector drifts and collisions of the trapped particles, these equations take full account of the effect of Esub(//) (of the trapped ion modes) on free and trapped particles, and of the effect of grad delta 0 (delta 0 = equilibrium fraction of trapped particles). From the new equations the linear-mode properties of the dissipative trapped-ion instability and the anomalous diffusion flux of the trapped particles are derived. (orig.) [de

Chimeric microbial rhodopsins for optical activation of Gs-proteins

Science.gov (United States)

Yoshida, Kazuho; Yamashita, Takahiro; Sasaki, Kengo; Inoue, Keiichi; Shichida, Yoshinori; Kandori, Hideki

2017-01-01

We previously showed that the chimeric proteins of microbial rhodopsins, such as light-driven proton pump bacteriorhodopsin (BR) and Gloeobacter rhodopsin (GR) that contain cytoplasmic loops of bovine rhodopsin, are able to activate Gt protein upon light absorption. These facts suggest similar protein structural changes in both the light-driven proton pump and animal rhodopsin. Here we report two trials to engineer chimeric rhodopsins, one for the inserted loop, and another for the microbial rhodopsin template. For the former, we successfully activated Gs protein by light through the incorporation of the cytoplasmic loop of β2-adrenergic receptor (β2AR). For the latter, we did not observe any G-protein activation for the light-driven sodium pump from Indibacter alkaliphilus (IndiR2) or a light-driven chloride pump halorhodopsin from Natronomonas pharaonis (NpHR), whereas the light-driven proton pump GR showed light-dependent G-protein activation. This fact suggests that a helix opening motion is common to G protein coupled receptor (GPCR) and GR, but not to IndiR2 and NpHR. Light-induced difference FTIR spectroscopy revealed similar structural changes between WT and the third loop chimera for each light-driven pump. A helical structural perturbation, which was largest for GR, was further enhanced in the chimera. We conclude that similar structural dynamics that occur on the cytoplasmic side of GPCR are needed to design chimeric microbial rhodopsins. PMID:29362703

A 2 GS/s 8-bit folding and interpolating ADC in 90 nm CMOS

International Nuclear Information System (INIS)

He Wenwei; Meng Qiao; Zhang Yi; Tang Kai

2014-01-01

A single-channel 2 GS/s 8-bit analog-to-digital converter in 90 nm CMOS process technology is presented. It utilizes cascade folding architecture, which incorporates an additional inter-stage sample-and-hold amplifier between the folding circuits to enhance the quantization time. It also uses the foreground on-chip digital-assisted calibration circuit to improve the linearity of the circuit. The post simulation results demonstrate that it has a differential nonlinearity < ±0.3 LSB and an integral nonlinearity < ±0.25 LSB at the Nyquist frequency. Moreover, 7.338 effective numbers of bits can be achieved at 2 GSPS. The whole chip area is 0.88 × 0.88 mm 2 with the pad. It consumes 210 mW from a 1.2 V single supply. (semiconductor integrated circuits)

Encryption and display of multiple-image information using computer-generated holography with modified GS iterative algorithm

Science.gov (United States)

Xiao, Dan; Li, Xiaowei; Liu, Su-Juan; Wang, Qiong-Hua

2018-03-01

In this paper, a new scheme of multiple-image encryption and display based on computer-generated holography (CGH) and maximum length cellular automata (MLCA) is presented. With the scheme, the computer-generated hologram, which has the information of the three primitive images, is generated by modified Gerchberg-Saxton (GS) iterative algorithm using three different fractional orders in fractional Fourier domain firstly. Then the hologram is encrypted using MLCA mask. The ciphertext can be decrypted combined with the fractional orders and the rules of MLCA. Numerical simulations and experimental display results have been carried out to verify the validity and feasibility of the proposed scheme.

Progress in the SSPX Spheromak

International Nuclear Information System (INIS)

McLean, H S; Woodruff, S; Hill, D N; Bulmer, R H; Cohen, B I; Hooper, E B; Moller, J; Ryutov, D D; Stallard, B W; Wood, R D; Holcomb, C T; Jarboe, T R; Romero-Talamas, C

2003-01-01

The spheromak, with its simply connected geometry, holds promise as a less expensive fusion reactor. It has reasonably good plasma beta and can be formed and sustained in steady state with a magnetized coaxial plasma gun. The Sustained Spheromak Physics Experiment (SSPX) shown in Fig. 1 was constructed to investigate the key issues of magnetic field generation and energy confinement. In addition to the coaxial gun, nine magnetic field coils are utilized to shape the vacuum magnetic flux. This flexibility allows operation in many different regimes producing very different plasma characteristics. Pulse length is extended and magnetic field strength is increased. Improved surface conditioning produces plasmas with low impurity content, and higher electron temperature, T e . Electron heat transport within the separatrix is reduced by a factor of 4. The results strongly suggest the existence of closed flux surfaces even though the plasma is connected to the coaxial source. The CORSICA Grad-Shafranov 2-d equilibrium code with data from edge magnetic probes along with T e and electron density ne from Thomson scattering is used to calculate internal profiles: normalized current γ = μ 0 J/B, safety factor = q, ohmic heating, thermal energy density, and thermal diffusivity = ξ e . Ohmic heating is calculated by assuming spatially constant Spitzer resistivity with Z eff =2.3 estimated by VUV spectroscopy

Transport modelling and gyrokinetic analysis of advanced high performance discharges

International Nuclear Information System (INIS)

Kinsey, J.E.; Imbeaux, F.; Staebler, G.M.; Budny, R.; Bourdelle, C.; Fukuyama, A.; Garbet, X.; Tala, T.; Parail, V.

2005-01-01

Predictive transport modelling and gyrokinetic stability analyses of demonstration hybrid (HYBRID) and advanced tokamak (AT) discharges from the International Tokamak Physics Activity (ITPA) profile database are presented. Both regimes have exhibited enhanced core confinement (above the conventional ITER reference H-mode scenario) but differ in their current density profiles. Recent contributions to the ITPA database have facilitated an effort to study the underlying physics governing confinement in these advanced scenarios. In this paper, we assess the level of commonality of the turbulent transport physics and the relative roles of the transport suppression mechanisms (i.e. E x B shear and Shafranov shift (α) stabilization) using data for select HYBRID and AT discharges from the DIII-D, JET and AUG tokamaks. GLF23 transport modelling and gyrokinetic stability analysis indicate that E x B shear and Shafranov shift stabilization play essential roles in producing the improved core confinement in both HYBRID and AT discharges. Shafranov shift stabilization is found to be more important in AT discharges than in HYBRID discharges. We have also examined the competition between the stabilizing effects of E x B shear and Shafranov shift stabilization and the destabilizing effects of higher safety factors and parallel velocity shear. Linear and nonlinear gyrokinetic simulations of idealized low and high safety factor cases reveal some interesting consequences. A low safety factor (i.e. HYBRID relevant) is directly beneficial in reducing the transport, and E x B shear stabilization can dominate parallel velocity shear destabilization allowing the turbulence to be quenched. However, at low-q/high current, Shafranov shift stabilization plays less of a role. Higher safety factors (as found in AT discharges), on the other hand, have larger amounts of Shafranov shift stabilization, but parallel velocity shear destabilization can prevent E x B shear quenching of the turbulent

Transport modeling and gyrokinetic analysis of advanced high performance discharges

International Nuclear Information System (INIS)

Kinsey, J.; Imbeaux, F.; Bourdelle, C.; Garbet, X.; Staebler, G.; Budny, R.; Fukuyama, A.; Tala, T.; Parail, V.

2005-01-01

Predictive transport modeling and gyrokinetic stability analyses of demonstration hybrid (HYBRID) and Advanced Tokamak (AT) discharges from the International Tokamak Physics Activity (ITPA) profile database are presented. Both regimes have exhibited enhanced core confinement (above the conventional ITER reference H-mode scenario) but differ in their current density profiles. Recent contributions to the ITPA database have facilitated an effort to study the underlying physics governing confinement in these advanced scenarios. In this paper, we assess the level of commonality of the turbulent transport physics and the relative roles of the transport suppression mechanisms (i.e. ExB shear and Shafranov shift (α) stabilization) using data for select HYBRID and AT discharges from the DIII-D, JET, and AUG tokamaks. GLF23 transport modeling and gyrokinetic stability analysis indicates that ExB shear and Shafranov shift stabilization play essential roles in producing the improved core confinement in both HYBRID and AT discharges. Shafranov shift stabilization is found to be more important in AT discharges than in HYBRID discharges. We have also examined the competition between the stabilizing effects of ExB shear and Shafranov shift stabilization and the destabilizing effects of higher safety factors and parallel velocity shear. Linear and nonlinear gyrokinetic simulations of idealized low and high safety factor cases reveals some interesting consequences. A low safety factor (i.e. HYBRID relevant) is directly beneficial in reducing the transport, and ExB shear stabilization can win out over parallel velocity shear destabilization allowing the turbulence to be quenched. However, at low-q/high current, Shafranov shift stabilization plays less of a role. Higher safety factors (as found in AT discharges), on the other hand, have larger amounts of Shafranov shift stabilization, but parallel velocity shear destabilization can prevent ExB shear quenching of the turbulent

Dense high-temperature plasma transport processes

International Nuclear Information System (INIS)

Giniyatova, Sh.G.

2002-01-01

In this work the transport processes in dense high-temperature semiclassical plasma are studied on the base of the kinetic equation, where the semiclassical potential was used, in its collision integral. The coefficient of plasma electrical conductivity, viscosity and thermal conductivity were received. There were compared with the other authors' results. The Grad's method was used obtaining of viscosity and thermal coefficients. (author)

Transport processes in ionized gases

International Nuclear Information System (INIS)

Kremer, G.M.

1997-01-01

Based on kinetic theory of gases and on the combined of Chapman-Enskog and Grad, the laws of Ohm, Fourier and Navier-Stokes are derived for a non-relativistic fully ionized gas. Moreover, the combined method is applied to the BGK model of the relativistic Boltzmann equation and the Ohm's law is derived for a relativistic fully ionized gas. (author)

Lab-scale preparations of Candida albicans and dual Candida albicans-Candida glabrata biofilms on the surface of medical-grade polyvinyl chloride (PVC) perfusion tube using a modified gravity-supported free-flow biofilm incubator (GS-FFBI).

Science.gov (United States)

Shao, Jing; Lu, KeQiao; Tian, Ge; Cui, YanYan; Yan, YuanYuan; Wang, TianMing; Zhang, XinLong; Wang, ChangZhong

2015-02-01

The assembly of a man-made gravity-supported free-flow biofilm incubator (GS-FFBI) was described, which was composed of a gas cushion injector and four incubators. The GS-FFBI had the characteristics of (i) a bottom-up flow direction, and (ii) lab-scale biofilm preparation without the use of a multichannel pump. Two opportunistic fungal strains, namely Candida albicans and Candida glabrata, were employed to incubate C. albicans and dual C. albicans-C. glabrata biofilms on the surface of medical-grade polyvinyl chloride perfusion tube. In terms of the results from {2, 3-bis (2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide} (XTT) assay, dry weight measurement, colony-forming unit counting, susceptibility test, and scanning electron microscopy, it was demonstrated that GS-FFBI could form both stable single and dual Candida biofilms with no significant variations among the four incubators or the three daily incubations within 21h, and could operate for at least 96h smoothly with no contamination of stock medium. The results also indicated, for the first time, that C. albicans and C. glabrata might be co-existent competitively and symbiotically in the dual biofilms with flowing media. GS-FFBI would be a useful device to study in vitro morphological and physiological features of microbial biofilms in the medical settings. Copyright © 2014 Elsevier B.V. All rights reserved.

An extended GS method for dense linear systems

Science.gov (United States)

Niki, Hiroshi; Kohno, Toshiyuki; Abe, Kuniyoshi

2009-09-01

Davey and Rosindale [K. Davey, I. Rosindale, An iterative solution scheme for systems of boundary element equations, Internat. J. Numer. Methods Engrg. 37 (1994) 1399-1411] derived the GSOR method, which uses an upper triangular matrix [Omega] in order to solve dense linear systems. By applying functional analysis, the authors presented an expression for the optimum [Omega]. Moreover, Davey and Bounds [K. Davey, S. Bounds, A generalized SOR method for dense linear systems of boundary element equations, SIAM J. Comput. 19 (1998) 953-967] also introduced further interesting results. In this note, we employ a matrix analysis approach to investigate these schemes, and derive theorems that compare these schemes with existing preconditioners for dense linear systems. We show that the convergence rate of the Gauss-Seidel method with preconditioner PG is superior to that of the GSOR method. Moreover, we define some splittings associated with the iterative schemes. Some numerical examples are reported to confirm the theoretical analysis. We show that the EGS method with preconditioner produces an extremely small spectral radius in comparison with the other schemes considered.

GUIDING NONLINEAR FORCE-FREE MODELING USING CORONAL OBSERVATIONS: FIRST RESULTS USING A QUASI-GRAD-RUBIN SCHEME

Energy Technology Data Exchange (ETDEWEB)

Malanushenko, A. [Department of Physics, Montana State University, Bozeman, MT (United States); Schrijver, C. J.; DeRosa, M. L. [Lockheed Martin Advanced Technology Center, Palo Alto, CA (United States); Wheatland, M. S.; Gilchrist, S. A. [Sydney Institute for Astronomy, School of Physics, University of Sydney (Australia)

2012-09-10

At present, many models of the coronal magnetic field rely on photospheric vector magnetograms, but these data have been shown to be problematic as the sole boundary information for nonlinear force-free field extrapolations. Magnetic fields in the corona manifest themselves in high-energy images (X-rays and EUV) in the shapes of coronal loops, providing an additional constraint that is not at present used as constraints in the computational domain, directly influencing the evolution of the model. This is in part due to the mathematical complications of incorporating such input into numerical models. Projection effects, confusion due to overlapping loops (the coronal plasma is optically thin), and the limited number of usable loops further complicate the use of information from coronal images. We develop and test a new algorithm to use images of coronal loops in the modeling of the solar coronal magnetic field. We first fit projected field lines with those of constant-{alpha} force-free fields to approximate the three-dimensional distribution of currents in the corona along a sparse set of trajectories. We then apply a Grad-Rubin-like iterative technique, which uses these trajectories as volume constraints on the values of {alpha}, to obtain a volume-filling nonlinear force-free model of the magnetic field, modifying a code and method presented by Wheatland. We thoroughly test the technique on known analytical and solar-like model magnetic fields previously used for comparing different extrapolation techniques and compare the results with those obtained by currently available methods relying only on the photospheric data. We conclude that we have developed a functioning method of modeling the coronal magnetic field by combining the line-of-sight component of the photospheric magnetic field with information from coronal images. Whereas we focus on the use of coronal loop information in combination with line-of-sight magnetograms, the method is readily extended to

GUIDING NONLINEAR FORCE-FREE MODELING USING CORONAL OBSERVATIONS: FIRST RESULTS USING A QUASI-GRAD-RUBIN SCHEME

International Nuclear Information System (INIS)

Malanushenko, A.; Schrijver, C. J.; DeRosa, M. L.; Wheatland, M. S.; Gilchrist, S. A.

2012-01-01

At present, many models of the coronal magnetic field rely on photospheric vector magnetograms, but these data have been shown to be problematic as the sole boundary information for nonlinear force-free field extrapolations. Magnetic fields in the corona manifest themselves in high-energy images (X-rays and EUV) in the shapes of coronal loops, providing an additional constraint that is not at present used as constraints in the computational domain, directly influencing the evolution of the model. This is in part due to the mathematical complications of incorporating such input into numerical models. Projection effects, confusion due to overlapping loops (the coronal plasma is optically thin), and the limited number of usable loops further complicate the use of information from coronal images. We develop and test a new algorithm to use images of coronal loops in the modeling of the solar coronal magnetic field. We first fit projected field lines with those of constant-α force-free fields to approximate the three-dimensional distribution of currents in the corona along a sparse set of trajectories. We then apply a Grad-Rubin-like iterative technique, which uses these trajectories as volume constraints on the values of α, to obtain a volume-filling nonlinear force-free model of the magnetic field, modifying a code and method presented by Wheatland. We thoroughly test the technique on known analytical and solar-like model magnetic fields previously used for comparing different extrapolation techniques and compare the results with those obtained by currently available methods relying only on the photospheric data. We conclude that we have developed a functioning method of modeling the coronal magnetic field by combining the line-of-sight component of the photospheric magnetic field with information from coronal images. Whereas we focus on the use of coronal loop information in combination with line-of-sight magnetograms, the method is readily extended to incorporate

Carbon steel protection in G.S. (Girlder sulfide) plants. CITROSOLV process influence. Pt. 6

International Nuclear Information System (INIS)

Lires, O.A.; Burkart, A.L.; Delfino, C.A.; Rojo, E.A.

1988-01-01

In order to protect carbon steel towers and piping of Girlder sulfide (G.S.) experimental heavy water plants against corrosion produced by the action of aqueous solutions of hydrogen sulfides, a method, previously published, was developed. Carbon steel, exposed to saturated aqueous solutions of hydrogen sulfide, forms iron sulfide scales. In oxygen free solutions evolution of corrosion follows the sequence: mackinawite → cubic ferrous sulfide → troilite → pyrrotite → pyrite. Scales formed by pyrrotite-pyrite or pyrite are the most protective layers (these are obtained at 130 deg C, 2 MPa, for periods of 14 days). CITROSOLV Process (Pfizer) is used to descaling and passivating stainless steel plant's components. This process must be used in mixed (carbon steel - stainless steel) circuits and may cause the formation of magnetite scales over the carbon steel. The influence of magnetite in the pyrrotite-pyrite scales formation is studied in this work. (Author) [es

3/2 or 5/2 for convective thermal transport?

International Nuclear Information System (INIS)

Duechs, D.F.

1989-07-01

To resolve frequent arguments on the form of the convective part of the thermal energy flux the relevant definitions and equations are compiled. The relative importance of the different terms involved is shown for Joint European Torus (JET) data. The choice of the ''adiabatic source terms'', p''centre dot''div v- ''->'' or v- ''->centre dot''grad p, decides the form of the convective heat flux. (author)

NuSTAR observations of the black holes GS 1354-645: Evidence of rapid black hole spin

DEFF Research Database (Denmark)

El-Batal, A. M.; Miller, J. M.; Reynolds, M. T.

2016-01-01

We present the results of a NuSTAR study of the dynamically confirmed stellar-mass black hole GS 1354-645. The source was observed during its 2015 "hard" state outburst; we concentrate on spectra from two relatively bright phases. In the higher-flux observation, the broadband NuSTAR spectra reveal...... a clear, strong disk reflection spectrum, blurred by a degree that requires a black hole spin of a = cf/GM(2) >= 0.98 (1 sigma statistical limits only). The fits also require a high inclination: 0 similar or equal to 75 (2)degrees. Strong "dips" are sometimes observed in the X-ray light curves of sources...... in stellar-mass black holes, and inner accretion flow geometries at moderate accretion rates....

Trigger design for a gamma ray detector of HIRFL-ETF

Science.gov (United States)

Du, Zhong-Wei; Su, Hong; Qian, Yi; Kong, Jie

2013-10-01

The Gamma Ray Array Detector (GRAD) is one subsystem of HIRFL-ETF (the External Target Facility (ETF) of the Heavy Ion Research Facility in Lanzhou (HIRFL)). It is capable of measuring the energy of gamma-rays with 1024 CsI scintillators in in-beam nuclear experiments. The GRAD trigger should select the valid events and reject the data from the scintillators which are not hit by the gamma-ray. The GRAD trigger has been developed based on the Field Programmable Gate Array (FPGAs) and PXI interface. It makes prompt trigger decisions to select valid events by processing the hit signals from the 1024 CsI scintillators. According to the physical requirements, the GRAD trigger module supplies 12-bit trigger information for the global trigger system of ETF and supplies a trigger signal for data acquisition (DAQ) system of GRAD. In addition, the GRAD trigger generates trigger data that are packed and transmitted to the host computer via PXI bus to be saved for off-line analysis. The trigger processing is implemented in the front-end electronics of GRAD and one FPGA of the GRAD trigger module. The logic of PXI transmission and reconfiguration is implemented in another FPGA of the GRAD trigger module. During the gamma-ray experiments, the GRAD trigger performs reliably and efficiently. The function of GRAD trigger is capable of satisfying the physical requirements.

Trigger design for a gamma ray detector of HIRFL-ETF

International Nuclear Information System (INIS)

Du Zhongwei; Su Hong; Qian Yi; Kong Jie

2013-01-01

The Gamma Ray Array Detector (GRAD) is one subsystem of HIRFL-ETF (the External Target Facility (ETF) of the Heavy Ion Research Facility in Lanzhou (HIRFL)). It is capable of measuring the energy of gamma-rays with 1024 CsI scintillators in in-beam nuclear experiments. The GRAD trigger should select the valid events and reject the data from the scintillators which are not hit by the gamma-ray. The GRAD trigger has been developed based on the Field Programmable Gate Array (FPGAs) and PXI interface. It makes prompt trigger decisions to select valid events by processing the hit signals from the 1024 CsI scintillators. According to the physical requirements, the GRAD trigger module supplies 12-bit trigger information for the global trigger system of ETF and supplies a trigger signal for data acquisition (DAQ) system of GRAD. In addition, the GRAD trigger generates trigger data that are packed and transmitted to the host computer via PXI bus to be saved for off-line analysis. The trigger processing is implemented in the front-end electronics of GRAD and one FPGA of the GRAD trigger module. The logic of PXI transmission and reconfiguration is implemented in another FPGA of the GRAD trigger module. During the gamma-ray experiments, the GRAD trigger performs reliably and efficiently. The function of GRAD trigger is capable of satisfying the physical requirements. (authors)

p-Euler equations and p-Navier-Stokes equations

Science.gov (United States)

Li, Lei; Liu, Jian-Guo

2018-04-01

We propose in this work new systems of equations which we call p-Euler equations and p-Navier-Stokes equations. p-Euler equations are derived as the Euler-Lagrange equations for the action represented by the Benamou-Brenier characterization of Wasserstein-p distances, with incompressibility constraint. p-Euler equations have similar structures with the usual Euler equations but the 'momentum' is the signed (p - 1)-th power of the velocity. In the 2D case, the p-Euler equations have streamfunction-vorticity formulation, where the vorticity is given by the p-Laplacian of the streamfunction. By adding diffusion presented by γ-Laplacian of the velocity, we obtain what we call p-Navier-Stokes equations. If γ = p, the a priori energy estimates for the velocity and momentum have dual symmetries. Using these energy estimates and a time-shift estimate, we show the global existence of weak solutions for the p-Navier-Stokes equations in Rd for γ = p and p ≥ d ≥ 2 through a compactness criterion.

Equating error in observed-score equating

NARCIS (Netherlands)

van der Linden, Willem J.

2006-01-01

Traditionally, error in equating observed scores on two versions of a test is defined as the difference between the transformations that equate the quantiles of their distributions in the sample and population of test takers. But it is argued that if the goal of equating is to adjust the scores of

Behind the scenes of GS: a professional fire and rescue service like no other

CERN Multimedia

Anaïs Schaeffer

2014-01-01

Meet the professionals at the top of their game working hard for the well-being of the CERN community. Meet the CERN Fire Brigade.   Highly-qualified professional firefighters CERN’s Fire and Rescue Service (FRS, GS-FB Group) currently consists of 58 professionals. These are highly sought-after positions: for just a handful of vacancies, hundreds of applications are submitted from all over Europe. And bear in mind that only professional firefighters with at least five years’ experience at a centre with high levels of operational activity may apply… and they must also have a good command of at least one of the Organization's two official languages. Once the pre-selection process is over, around twenty candidates progress to the next stage, where they are really put through their paces with language tests, theory exams and exercises on real fires. “For the practical part, all candidates are evaluated on their responses to a real fire," ...

Radiographic findings and Gs-alpha bioactivity studies and mutation screening in acrodysostosis indicate a different etiology from pseudohypoparathyroidism

International Nuclear Information System (INIS)

Graham, J.M. Jr.; Krakow, D.; Smith, A.K.; Lachman, R.S.

2001-01-01

Acrodysostosis is an uncommon skeletal dysplasia associated with nasal hypoplasia, midface deficiency, severe brachydactyly, and varying degrees of hearing loss and mental retardation. Previous publications have suggested that it may be difficult to distinguish acrodystostosis from pseudohypoparathyroidism on clinical grounds, but acrodysostosis does appear to have distinct clinical and radiologic findings. Spinal stenosis is an underappreciated risk in acrodysostosis, despite the reported loss of normal caudal widening of the lumbar interpediculate distance on AP spine radiographs in the original report of this disorder by Robinow et al., with confirmation of these radiographic findings by Butler et al. We report two sporadic cases of acrodysostosis, one of which required decompressive laminectomy for symptomatic spinal stenosis, and review 11 cases of acrodysostosis from 9 families that were submitted to the International Skeletal Dysplasia Registry. The objective of this report is to determine the frequency and severity of spinal stenosis in patients with acrodysostosis and to summarize the clinical and radiographic findings of acrodysostosis in an effort to distinguish acrodysostosis clearly from pseudohypoparathyroidism. The pattern of brachydactyly differs between these two conditions, and varying degrees of spinal stenosis are characteristic of acrodysostosis. Both our index patients with acrodysostosis had normal bioactivity of the alpha subunit of the Gs protein, therefore indicating that acrodysostosis has a different pathogenesis from pseudohypoparathyroidism. Furthermore, single-strand confirmational polymorphism (SSCP) analysis failed to demonstrate any confirmational alterations in the coding exons of the Gs alpha gene. These radiographic and laboratory findings substantiate that acrodysostosis is clinically different from pseudohypoparathyroidism and that it is necessary to follow patients with acrodysostosis for signs of spinal stenosis. (orig.)

A method for determining the branching ratio for the superallowed decay: 10C(0+, gs)→10B(0+, 1.74 MeV)+e++ν

International Nuclear Information System (INIS)

Kroupa, M.A.; Freedman, S.J.; Barker, P.H.; Ferguson, S.M.

1991-01-01

We describe a new way of determining the strength of the superallowed branch of the β-decay of 10 C, 10 C(0 + , gs) → 10 B(0 + , 1.74 MeV) + e + + ν. Precise knowledge of the branching ratio is needed to compute the experimental ft-value and the weak vector coupling constant. (orig.)

Analytic, high β, flux conserving equilibria for cylindrical tokamaks

International Nuclear Information System (INIS)

Sigmar, D.J.; Vahala, G.

1978-09-01

Using Grad's theory of generalized differential equations, the temporal evolution from low to high β due to ''adiabatic'' and nonadiabatic (i.e., neutral beam injection) heating of a cylindrical tokamak plasma with circular cross section and peaked current profiles is calculated analytically. The influence of shaping the initial safety factor profile and the beam deposition profile and the effect of minor radius compression on the equilibrium is analyzed

Analytic, high β, flux conserving equilibria for cylindrical tokamaks

International Nuclear Information System (INIS)

Sigmar, D.J.; Vahala, G.

1978-01-01

Using Grad's theory of generalized differential equations, the temporal evolution from low to high β due to ''adiabatic'' and nonadiabatic (i.e., neutral beam injection) heating of a cylindrical tokamak plasma with circular cross section and peaked current profiles is calculated analytically. The influence of shaping the initial safety factor profile and the beam deposition profile and the effect of minor radius compression on the equilibrium is analyzed

A soft X-ray spectral episode for the Clocked Burster, GS 1826-24 as measured by Swift and NuSTAR

DEFF Research Database (Denmark)

Chenevez, J.; Galloway, D.K.; in ’t Zand, J.J.M.

2016-01-01

We report on NuSTAR and Swift observations of a soft state of the neutron star low-mass X-ray binary GS 1826–24, commonly known as the "clocked" burster. The transition to the soft state was recorded in 2014 June through an increase of the 2–20 keV source intensity measured by MAXI, simultaneous ...

equateIRT: An R Package for IRT Test Equating

Directory of Open Access Journals (Sweden)

Michela Battauz

2015-12-01

Full Text Available The R package equateIRT implements item response theory (IRT methods for equating different forms composed of dichotomous items. In particular, the IRT models included are the three-parameter logistic model, the two-parameter logistic model, the one-parameter logistic model and the Rasch model. Forms can be equated when they present common items (direct equating or when they can be linked through a chain of forms that present common items in pairs (indirect or chain equating. When two forms can be equated through different paths, a single conversion can be obtained by averaging the equating coefficients. The package calculates direct and chain equating coefficients. The averaging of direct and chain coefficients that link the same two forms is performed through the bisector method. Furthermore, the package provides analytic standard errors of direct, chain and average equating coefficients.

Preliminary investigations of equilibrium reconstruction quality during ELMy and ELM-free phases on JET

International Nuclear Information System (INIS)

Gelfusa, M.; Murari, A.; Peluso, E.; Gaudio, P.; Orsitto, F.P.; Gerasimov, S.

2013-01-01

On JET, the magnetic topology is normally derived from the code EFIT, which solves the Grad–Shafranov equation with constraints imposed by the available measurements, typically the pick-up coils. Both the code and the measurements are expected to perform worse during ELMs. To assess this hypothesis, various statistical indicators, based on the values of the residuals and their probability distribution, have been calculated. They all show that the quality of EFIT reconstructions is clearly better in absence of ELMs. How the responsibility, for the lower quality of the reconstructions, is shared between the measurements and EFIT is a subject under investigation. © 2001 Elsevier Science. All rights reserved

Ressenya a Grifoll, Isabel, Julián Acebrón, Flocel Sabaté (eds. (2014: Cartografies de l’ànima. Identitat, memòria i escriptura, Lleida, Pagès Editors, 2014, 248 pàgs. ISBN:978-84-9975-517-5; i Acebrón, Julián, Isabel Grifoll, Flocel Sabaté (eds. (2015: La Construcció d’identitats imaginades. Literatura medieval i ideologia, Lleida, Pagès Editors, 2015, 320 pàgs. ISBN:978-84-9975-704-9

Directory of Open Access Journals (Sweden)

Vicent Martines

2016-12-01

Full Text Available Review to Grifoll, Isabel, Julián Acebrón, Flocel Sabaté (eds. (2014: Cartografies de l’ànima. Identitat, memòria i escriptura, Lleida, Pagès Editors, 2014, 248 pàgs. ISBN:978-84-9975-517-5; and Acebrón, Julián, Isabel Grifoll, Flocel Sabaté (eds. (2015: La Construcció d’identitats imaginades. Literatura medieval i ideologia, Lleida, Pagès Editors, 2015, 320 pàgs. ISBN:978-84-9975-704-9

Computing generalized Langevin equations and generalized Fokker-Planck equations.

Science.gov (United States)

Darve, Eric; Solomon, Jose; Kia, Amirali

2009-07-07

The Mori-Zwanzig formalism is an effective tool to derive differential equations describing the evolution of a small number of resolved variables. In this paper we present its application to the derivation of generalized Langevin equations and generalized non-Markovian Fokker-Planck equations. We show how long time scales rates and metastable basins can be extracted from these equations. Numerical algorithms are proposed to discretize these equations. An important aspect is the numerical solution of the orthogonal dynamics equation which is a partial differential equation in a high dimensional space. We propose efficient numerical methods to solve this orthogonal dynamics equation. In addition, we present a projection formalism of the Mori-Zwanzig type that is applicable to discrete maps. Numerical applications are presented from the field of Hamiltonian systems.

Development of kinetics equations from the Boltzmann equation; Etablissement des equations de la cinetique a partir de l'equation de Boltzmann

Energy Technology Data Exchange (ETDEWEB)

Plas, R.

1962-07-01

The author reports a study on kinetics equations for a reactor. He uses the conventional form of these equations but by using a dynamic multiplication factor. Thus, constants related to delayed neutrons are not modified by efficiency factors. The author first describes the theoretic kinetic operation of a reactor and develops the associated equations. He reports the development of equations for multiplication factors.

Ideal relaxation of the Hopf fibration

Science.gov (United States)

Smiet, Christopher Berg; Candelaresi, Simon; Bouwmeester, Dirk

2017-07-01

Ideal magnetohydrodynamics relaxation is the topology-conserving reconfiguration of a magnetic field into a lower energy state where the net force is zero. This is achieved by modeling the plasma as perfectly conducting viscous fluid. It is an important tool for investigating plasma equilibria and is often used to study the magnetic configurations in fusion devices and astrophysical plasmas. We study the equilibrium reached by a localized magnetic field through the topology conserving relaxation of a magnetic field based on the Hopf fibration in which magnetic field lines are closed circles that are all linked with one another. Magnetic fields with this topology have recently been shown to occur in non-ideal numerical simulations. Our results show that any localized field can only attain equilibrium if there is a finite external pressure, and that for such a field a Taylor state is unattainable. We find an equilibrium plasma configuration that is characterized by a lowered pressure in a toroidal region, with field lines lying on surfaces of constant pressure. Therefore, the field is in a Grad-Shafranov equilibrium. Localized helical magnetic fields are found when plasma is ejected from astrophysical bodies and subsequently relaxes against the background plasma, as well as on earth in plasmoids generated by, e.g., a Marshall gun. This work shows under which conditions an equilibrium can be reached and identifies a toroidal depression as the characteristic feature of such a configuration.

Breaking Spaces and Forms for the DPG Method and Applications Including Maxwell Equations

Science.gov (United States)

2015-07-01

is also obvious from the calculus of variations that among all Hpdiv,Kq-extensions of σ̂n, the solution of (2.3) has the minimal Hpdiv,Kq norm (i.e...has vanishing surface curl, so it must equal a surface gradient , i.e., EJ “ gradJ v for some v P P cp`3pBKq. Moreover, since EJ vanishes on all edges, v...BK φn ¨curl e “ 0 for all φ P P 0,Kp`2pBKq. But this is obvious from the fact that e is a gradient . Next, we need to show that σ “ curlpΠcurlp`3Eq is

Sociālie mediji kā ilgtspējīgs mārketinga instruments.

OpenAIRE

Kudlāne, Maija

2012-01-01

Ietekme, kādu sociālie mediji atstāj uz patērētāja ikdienas dzīvi ir neiedomājami liela. Tāpēc sociālo mediju mārketings ir attīstījies kā atsevišķa nozare. Pastāv dažādi viedokļi par to vai sociālo mediju mārketings ir ilgtspējīgs vai tā ir tikai mirkļa tendence. Darba mērķis ir izpētīt sociālo mediju mārketinga īpatnības un pielietojumu atkarībā no mārketinga mērķa, mērķa auditorijas iezīmēm, ekonomiskiem un kultūras faktoriem, kā arī izprast tā nākotnes potenciālu. Darba izpētes pro...

A 5bit 1GS/s 2.7mW 0.05mm^2 asynchronous digital slope ADC in 90nm CMOS for IR UWB radio

NARCIS (Netherlands)

Ding, M.; Harpe, P.J.A.; Hegt, J.A.; Philips, K.J.P.; Groot, de H.W.H.; Roermund, van A.H.M.

2012-01-01

A 5bit 1GS/s 0.05mm2 4× time-interleaved asynchronous digital slope ADC in 90nm CMOS for IR UWB radio is presented. New delay cells are introduced to double the speed over prior art, yielding the 250MS/s single-channel slope converter. A self-disabled comparator eliminates static leakage and

Simple equation method for nonlinear partial differential equations and its applications

Directory of Open Access Journals (Sweden)

Taher A. Nofal

2016-04-01

Full Text Available In this article, we focus on the exact solution of the some nonlinear partial differential equations (NLPDEs such as, Kodomtsev–Petviashvili (KP equation, the (2 + 1-dimensional breaking soliton equation and the modified generalized Vakhnenko equation by using the simple equation method. In the simple equation method the trial condition is the Bernoulli equation or the Riccati equation. It has been shown that the method provides a powerful mathematical tool for solving nonlinear wave equations in mathematical physics and engineering problems.

Étude numérique du couplage thermohydromécanique dans les roches. Influence des termes de couplage non linéaires pour un matériau isotrope linéaire Numerical Analysis of a Thermohydromechanical Coupling in Rocks. Influence of Nonlinear Coupling Terms on a Linear Isotropic Material

Directory of Open Access Journals (Sweden)

Henry J. P.

2006-11-01

Full Text Available Nous présentons dans ce travail une étude numérique basée sur la méthode des éléments finis, du comportement thermoporoélastique de certaines roches. Les trois effets de couplage : déformabilité de la roche, pression interstitielle et température sont pris en compte simultanément dans la résolution numérique. Une application simple sur un puits pétrolier en conditions axisymétriques est finalement présentée afin de dégager en particulier l'influence du terme de couplage convectif non linéaire, obtenu dans l'équation de diffusivité thermique, sur l'évolution de la température et de la pression interstitielle autour du forage. This article describes a finite-element method for solving the problem of nonlinear coupling between interstitial pressure and temperature during stress on a poroelastic rock. Such coupling phenomena occur during massive injection of cold water into a petroleum borehole for example. The implementation of such a numerical solution, used here with the assumption of small deformations, first requires a review of the behavior law of the material (Eq. 2. 2 and of the equations for hydraulic diffusivity (Eq. 2. 3 and thermal diffusivity (Eq. 2. 4. This last equation (2. 4 is the one containing the nonlinear coupling terms in Grad P Grad P and Grad T. Grad P. During simulation of flow at a high flow rate, these products can no longer be neglected as shown by the results in Fig. 2. The variational formulation of the problem is then determined in relation to the three equations for equilibrium, thermal diffusivity and hydraulic diffusivity. After geometric and temporal discretizations, this formulation leads to a finite-element calculating scheme resulting in the simultaneous solving of all three equations. This solution, based on the inversion of the system of equations (2. 15, requires the updating of the rigidity matrix at each time step to take nonlinear coupling into consideration. Calculations with an

Extended rate equations

International Nuclear Information System (INIS)

Shore, B.W.

1981-01-01

The equations of motion are discussed which describe time dependent population flows in an N-level system, reviewing the relationship between incoherent (rate) equations, coherent (Schrodinger) equations, and more general partially coherent (Bloch) equations. Approximations are discussed which replace the elaborate Bloch equations by simpler rate equations whose coefficients incorporate long-time consequences of coherence

Numerical Solution of Heun Equation Via Linear Stochastic Differential Equation

Directory of Open Access Journals (Sweden)

Hamidreza Rezazadeh

2014-05-01

Full Text Available In this paper, we intend to solve special kind of ordinary differential equations which is called Heun equations, by converting to a corresponding stochastic differential equation(S.D.E.. So, we construct a stochastic linear equation system from this equation which its solution is based on computing fundamental matrix of this system and then, this S.D.E. is solved by numerically methods. Moreover, its asymptotic stability and statistical concepts like expectation and variance of solutions are discussed. Finally, the attained solutions of these S.D.E.s compared with exact solution of corresponding differential equations.

A generalization of the simplest equation method and its application to (3+1)-dimensional KP equation and generalized Fisher equation

International Nuclear Information System (INIS)

Zhao, Zhonglong; Zhang, Yufeng; Han, Zhong; Rui, Wenjuan

2014-01-01

In this paper, the simplest equation method is used to construct exact traveling solutions of the (3+1)-dimensional KP equation and generalized Fisher equation. We summarize the main steps of the simplest equation method. The Bernoulli and Riccati equation are used as simplest equations. This method is straightforward and concise, and it can be applied to other nonlinear partial differential equations

Some of the dominant cyanobacteria and algae populating the aquatic and hydro-terrestrial habitats of Petuniabukta Bay in Svalbard in the Arctic; Niektore dominantne cyanobakterie a riasy osidlujuce akvaticke a hydroterestricke biotopy zatoky Petuniabukta na Svalbarde v Arktide

Energy Technology Data Exchange (ETDEWEB)

Raabova, L; Kovacik, L [Univerzita Komenskeho v Bratislave, Prirodovedecka fakulta, Katedra botaniky, 81102 Bratislava (Slovakia); Elster, J [Centrum polarni ekologie, Prirodovedecka fakulta, Jihoceska Universita, 37005 Ceske Budejovice (Czech Republic)

2012-04-25

This is fycologic research of the Svalbard, which is a summary term for all islands situated between 10 grad to 30 grad E and 74 grad to 81 grad latitude in the European part of the Arctic. Three selected sites within the bay Petuniabukta (78 grad 40' NL, 16 grad 27' E) at the end of the Gulf Billefjorden, located in the central part of the largest island of Svalbard were studied. Collection took place in June 2011 and we recorded totally more than 40 kinds of algae and cyanobacteria. Algae were the most abundant species. From cyanobacteria there was a predominance of filamentous Phormidium autumnale, from algae the representatives of genera Monoraphidium sp. div. and Scenedesmus sp. div. These are only partial results as a part of a more wider conceived research of these phototrophic micro-organisms in this area. (authors)

Lattice Boltzmann approach for complex nonequilibrium flows.

Science.gov (United States)

Montessori, A; Prestininzi, P; La Rocca, M; Succi, S

2015-10-01

We present a lattice Boltzmann realization of Grad's extended hydrodynamic approach to nonequilibrium flows. This is achieved by using higher-order isotropic lattices coupled with a higher-order regularization procedure. The method is assessed for flow across parallel plates and three-dimensional flows in porous media, showing excellent agreement of the mass flow with analytical and numerical solutions of the Boltzmann equation across the full range of Knudsen numbers, from the hydrodynamic regime to ballistic motion.

Analysis of wave equation in electromagnetic field by Proca equation

International Nuclear Information System (INIS)

Pamungkas, Oky Rio; Soeparmi; Cari

2017-01-01

This research is aimed to analyze wave equation for the electric and magnetic field, vector and scalar potential, and continuity equation using Proca equation. Then, also analyze comparison of the solution on Maxwell and Proca equation for scalar potential and electric field, both as a function of distance and constant wave number. (paper)

Comparison of Kernel Equating and Item Response Theory Equating Methods

Science.gov (United States)

Meng, Yu

2012-01-01

The kernel method of test equating is a unified approach to test equating with some advantages over traditional equating methods. Therefore, it is important to evaluate in a comprehensive way the usefulness and appropriateness of the Kernel equating (KE) method, as well as its advantages and disadvantages compared with several popular item…

Integral equations

CERN Document Server

Moiseiwitsch, B L

2005-01-01

Two distinct but related approaches hold the solutions to many mathematical problems--the forms of expression known as differential and integral equations. The method employed by the integral equation approach specifically includes the boundary conditions, which confers a valuable advantage. In addition, the integral equation approach leads naturally to the solution of the problem--under suitable conditions--in the form of an infinite series.Geared toward upper-level undergraduate students, this text focuses chiefly upon linear integral equations. It begins with a straightforward account, acco

Partial Differential Equations

CERN Document Server

1988-01-01

The volume contains a selection of papers presented at the 7th Symposium on differential geometry and differential equations (DD7) held at the Nankai Institute of Mathematics, Tianjin, China, in 1986. Most of the contributions are original research papers on topics including elliptic equations, hyperbolic equations, evolution equations, non-linear equations from differential geometry and mechanics, micro-local analysis.

Nonlinear evolution equations

CERN Document Server

Uraltseva, N N

1995-01-01

This collection focuses on nonlinear problems in partial differential equations. Most of the papers are based on lectures presented at the seminar on partial differential equations and mathematical physics at St. Petersburg University. Among the topics explored are the existence and properties of solutions of various classes of nonlinear evolution equations, nonlinear imbedding theorems, bifurcations of solutions, and equations of mathematical physics (Navier-Stokes type equations and the nonlinear Schrödinger equation). The book will be useful to researchers and graduate students working in p

FMTLxLyLz DIMENSIONAL EQUAT DIMENSIONAL EQUATION ...

African Journals Online (AJOL)

eobe

plant made of 12mm thick steel plate was used in de steel plate ... water treatment plant. ... ameters affecting filtration processes were used to derive an equation usin ..... system. However, in deriving the equation onl terms are incorporated.

Predict-first experimental analysis using automated and integrated magnetohydrodynamic modeling

Science.gov (United States)

Lyons, B. C.; Paz-Soldan, C.; Meneghini, O.; Lao, L. L.; Weisberg, D. B.; Belli, E. A.; Evans, T. E.; Ferraro, N. M.; Snyder, P. B.

2018-05-01

An integrated-modeling workflow has been developed for the purpose of performing predict-first analysis of transient-stability experiments. Starting from an existing equilibrium reconstruction from a past experiment, the workflow couples together the EFIT Grad-Shafranov solver [L. Lao et al., Fusion Sci. Technol. 48, 968 (2005)], the EPED model for the pedestal structure [P. B. Snyder et al., Phys. Plasmas 16, 056118 (2009)], and the NEO drift-kinetic-equation solver [E. A. Belli and J. Candy, Plasma Phys. Controlled Fusion 54, 015015 (2012)] (for bootstrap current calculations) in order to generate equilibria with self-consistent pedestal structures as the plasma shape and various scalar parameters (e.g., normalized β, pedestal density, and edge safety factor [q95]) are changed. These equilibria are then analyzed using automated M3D-C1 extended-magnetohydrodynamic modeling [S. C. Jardin et al., Comput. Sci. Discovery 5, 014002 (2012)] to compute the plasma response to three-dimensional magnetic perturbations. This workflow was created in conjunction with a DIII-D experiment examining the effect of triangularity on the 3D plasma response. Several versions of the workflow were developed, and the initial ones were used to help guide experimental planning (e.g., determining the plasma current necessary to maintain the constant edge safety factor in various shapes). Subsequent validation with the experimental results was then used to revise the workflow, ultimately resulting in the complete model presented here. We show that quantitative agreement was achieved between the M3D-C1 plasma response calculated for equilibria generated by the final workflow and equilibria reconstructed from experimental data. A comparison of results from earlier workflows is used to show the importance of properly matching certain experimental parameters in the generated equilibria, including the normalized β, pedestal density, and q95. On the other hand, the details of the pedestal

Kinetic equations for an unstable plasma; Equations cinetiques d'un plasma instable

Energy Technology Data Exchange (ETDEWEB)

Laval, G; Pellat, R [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1968-07-01

In this work, we establish the plasma kinetic equations starting from the Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy of equations. We demonstrate that relations existing between correlation functions may help to justify the truncation of the hierarchy. Then we obtain the kinetic equations of a stable or unstable plasma. They do not reduce to an equation for the one-body distribution function, but generally involve two coupled equations for the one-body distribution function and the spectral density of the fluctuating electric field. We study limiting cases where the Balescu-Lenard equation, the quasi-linear theory, the Pines-Schrieffer equations and the equations of weak turbulence in the random phase approximation are recovered. At last we generalise the H-theorem for the system of equations and we define conditions for irreversible behaviour. (authors) [French] Dans ce travail nous etablissons les equations cinetiques d'un plasma a partir des equations de la recurrence de Bogoliubov, Born, Green, Kirkwood et Yvon. Nous demontrons qu'entre les fonctions de correlation d'un plasma existent des relations qui permettent de justifier la troncature de la recurrence. Nous obtenons alors les equations cinetiques d'un plasma stable ou instable. En general elles ne se reduisent pas a une equation d'evolution pour la densite simple, mais se composent de deux equations couplees portant sur la densite simple et la densite spectrale du champ electrique fluctuant. Nous etudions le cas limites ou l'on retrouve l'equation de Balescu-Lenard, les equations de la theorie quasi-lineaire, les equations de Pines et Schrieffer et les equations de la turbulence faible dans l'approximation des phases aleatoires. Enfin, nous generalisons le theoreme H pour ce systeme d'equations et nous precisons les conditions d'evolution irreversible. (auteurs)

equate: An R Package for Observed-Score Linking and Equating

Directory of Open Access Journals (Sweden)

Anthony D. Albano

2016-10-01

Full Text Available The R package equate contains functions for observed-score linking and equating under single-group, equivalent-groups, and nonequivalent-groups with anchor test(s designs. This paper introduces these designs and provides an overview of observed-score equating with details about each of the supported methods. Examples demonstrate the basic functionality of the equate package.

The SERTS-97 Rocket Experiment on Study Activity on the Sun: Flight 36.167-GS on 1997 November 18

Science.gov (United States)

Swartz, Marvin; Condor, Charles E.; Davila, Joseph M.; Haas, J. Patrick; Jordan, Stuart D.; Linard, David L.; Miko, Joseph J.; Nash, I. Carol; Novello, Joseph; Payne, Leslie J.;

Spearfishing regulation benefits artisanal fisheries: the ReGS indicator and its application to a multiple-use Mediterranean marine protected area.

Science.gov (United States)

Rocklin, Delphine; Tomasini, Jean-Antoine; Culioli, Jean-Michel; Pelletier, Dominique; Mouillot, David

2011-01-01

The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA) and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR), a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE) increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1) in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation.

Spearfishing regulation benefits artisanal fisheries: the ReGS indicator and its application to a multiple-use Mediterranean marine protected area.

Directory of Open Access Journals (Sweden)

Delphine Rocklin

Full Text Available The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR, a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1 in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation.

Chemical Equation Balancing.

Science.gov (United States)

Blakley, G. R.

1982-01-01

Reviews mathematical techniques for solving systems of homogeneous linear equations and demonstrates that the algebraic method of balancing chemical equations is a matter of solving a system of homogeneous linear equations. FORTRAN programs using this matrix method to chemical equation balancing are available from the author. (JN)

A new auxiliary equation and exact travelling wave solutions of nonlinear equations

International Nuclear Information System (INIS)

Sirendaoreji

2006-01-01

A new auxiliary ordinary differential equation and its solutions are used for constructing exact travelling wave solutions of nonlinear partial differential equations in a unified way. The main idea of this method is to take full advantage of the auxiliary equation which has more new exact solutions. More new exact travelling wave solutions are obtained for the quadratic nonlinear Klein-Gordon equation, the combined KdV and mKdV equation, the sine-Gordon equation and the Whitham-Broer-Kaup equations

Optimization of cell line development in the GS-CHO expression system using a high-throughput, single cell-based clone selection system.

Science.gov (United States)

Nakamura, Tsuyoshi; Omasa, Takeshi

2015-09-01

Therapeutic antibodies are commonly produced by high-expressing, clonal and recombinant Chinese hamster ovary (CHO) cell lines. Currently, CHO cells dominate as a commercial production host because of their ease of use, established regulatory track record, and safety profile. CHO-K1SV is a suspension, protein-free-adapted CHO-K1-derived cell line employing the glutamine synthetase (GS) gene expression system (GS-CHO expression system). The selection of high-producing mammalian cell lines is a crucial step in process development for the production of therapeutic antibodies. In general, cloning by the limiting dilution method is used to isolate high-producing monoclonal CHO cells. However, the limiting dilution method is time consuming and has a low probability of monoclonality. To minimize the duration and increase the probability of obtaining high-producing clones with high monoclonality, an automated single cell-based clone selector, the ClonePix FL system, is available. In this study, we applied the high-throughput ClonePix FL system for cell line development using CHO-K1SV cells and investigated efficient conditions for single cell-based clone selection. CHO-K1SV cell growth at the pre-picking stage was improved by optimizing the formulation of semi-solid medium. The efficiency of picking and cell growth at the post-picking stage was improved by optimization of the plating time without decreasing the diversity of clones. The conditions for selection, including the medium formulation, were the most important factors for the single cell-based clone selection system to construct a high-producing CHO cell line. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

On a functional equation related to the intermediate long wave equation

International Nuclear Information System (INIS)

Hone, A N W; Novikov, V S

2004-01-01

We resolve an open problem stated by Ablowitz et al (1982 J. Phys. A: Math. Gen. 15 781) concerning the integral operator appearing in the intermediate long wave equation. We explain how this is resolved using the perturbative symmetry approach introduced by one of us with Mikhailov. By solving a certain functional equation, we prove that the intermediate long wave equation and the Benjamin-Ono equation are the unique integrable cases within a particular class of integro-differential equations. Furthermore, we explain how the perturbative symmetry approach is naturally extended to treat equations on a periodic domain. (letter to the editor)

Some New Integrable Equations from the Self-Dual Yang-Mills Equations

International Nuclear Information System (INIS)

Ivanova, T.A.; Popov, A.D.

1994-01-01

Using the symmetry reductions of the self-dual Yang-Mills (SDYM) equations in (2+2) dimensions, we introduce new integrable equations which are 'deformations' of the chiral model in (2+1) dimensions, generalized nonlinear Schroedinger, Korteweg-de Vries, Toda lattice, Garnier, Euler-Arnold, generalized Calogero-Moser and Euler-Calogero-Moser equations. The Lax pairs for all of these equations are derived by the symmetry reductions of the Lax pair for the SDYM equations. 34 refs

Auxiliary equation method for solving nonlinear partial differential equations

International Nuclear Information System (INIS)

Sirendaoreji,; Jiong, Sun

2003-01-01

By using the solutions of an auxiliary ordinary differential equation, a direct algebraic method is described to construct several kinds of exact travelling wave solutions for some nonlinear partial differential equations. By this method some physically important nonlinear equations are investigated and new exact travelling wave solutions are explicitly obtained with the aid of symbolic computation

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS.

Directory of Open Access Journals (Sweden)

Ana Maria Fernandez-Pujals

Full Text Available The heritability of Major Depressive Disorder (MDD has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently, the heritability of MDD has been estimated on large populations from registries such as the Swedish, Finnish, and Chinese cohorts. Family-based designs utilise a number of different relationships and provide an alternative means of estimating heritability. Generation Scotland: Scottish Family Health Study (GS:SFHS is a large (n = 20,198, family-based population study designed to identify the genetic determinants of common diseases, including Major Depressive Disorder. Two thousand seven hundred and six individuals were SCID diagnosed with MDD, 13.5% of the cohort, from which we inferred a population prevalence of 12.2% (95% credible interval: 11.4% to 13.1%. Increased risk of MDD was associated with being female, unemployed due to a disability, current smokers, former drinkers, and living in areas of greater social deprivation. The heritability of MDD in GS:SFHS was between 28% and 44%, estimated from a pedigree model. The genetic correlation of MDD between sexes, age of onset, and illness course were examined and showed strong genetic correlations. The genetic correlation between males and females with MDD was 0.75 (0.43 to 0.99; between earlier (≤ age 40 and later (> age 40 onset was 0.85 (0.66 to 0.98; and between single and recurrent episodic illness course was 0.87 (0.72 to 0.98. We found that the heritability of recurrent MDD illness course was significantly greater than the heritability of single MDD illness course. The study confirms a moderate genetic contribution to depression, with a small contribution of the common family environment (variance proportion = 0.07, CI: 0.01 to 0.15, and supports the relationship of MDD with previously identified risk factors. This study did not find robust support for genetic differences in MDD due to sex, age of onset, or illness course. However

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS).

Science.gov (United States)

Fernandez-Pujals, Ana Maria; Adams, Mark James; Thomson, Pippa; McKechanie, Andrew G; Blackwood, Douglas H R; Smith, Blair H; Dominiczak, Anna F; Morris, Andrew D; Matthews, Keith; Campbell, Archie; Linksted, Pamela; Haley, Chris S; Deary, Ian J; Porteous, David J; MacIntyre, Donald J; McIntosh, Andrew M

2015-01-01

The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently, the heritability of MDD has been estimated on large populations from registries such as the Swedish, Finnish, and Chinese cohorts. Family-based designs utilise a number of different relationships and provide an alternative means of estimating heritability. Generation Scotland: Scottish Family Health Study (GS:SFHS) is a large (n = 20,198), family-based population study designed to identify the genetic determinants of common diseases, including Major Depressive Disorder. Two thousand seven hundred and six individuals were SCID diagnosed with MDD, 13.5% of the cohort, from which we inferred a population prevalence of 12.2% (95% credible interval: 11.4% to 13.1%). Increased risk of MDD was associated with being female, unemployed due to a disability, current smokers, former drinkers, and living in areas of greater social deprivation. The heritability of MDD in GS:SFHS was between 28% and 44%, estimated from a pedigree model. The genetic correlation of MDD between sexes, age of onset, and illness course were examined and showed strong genetic correlations. The genetic correlation between males and females with MDD was 0.75 (0.43 to 0.99); between earlier (≤ age 40) and later (> age 40) onset was 0.85 (0.66 to 0.98); and between single and recurrent episodic illness course was 0.87 (0.72 to 0.98). We found that the heritability of recurrent MDD illness course was significantly greater than the heritability of single MDD illness course. The study confirms a moderate genetic contribution to depression, with a small contribution of the common family environment (variance proportion = 0.07, CI: 0.01 to 0.15), and supports the relationship of MDD with previously identified risk factors. This study did not find robust support for genetic differences in MDD due to sex, age of onset, or illness course. However, we found

The equationally-defined commutator a study in equational logic and algebra

CERN Document Server

Czelakowski, Janusz

2015-01-01

This monograph introduces and explores the notions of a commutator equation and the equationally-defined commutator from the perspective of abstract algebraic logic.  An account of the commutator operation associated with equational deductive systems is presented, with an emphasis placed on logical aspects of the commutator for equational systems determined by quasivarieties of algebras.  The author discusses the general properties of the equationally-defined commutator, various centralization relations for relative congruences, the additivity and correspondence properties of the equationally-defined commutator, and its behavior in finitely generated quasivarieties. Presenting new and original research not yet considered in the mathematical literature, The Equationally-Defined Commutator will be of interest to professional algebraists and logicians, as well as graduate students and other researchers interested in problems of modern algebraic logic.

A Comparison between Linear IRT Observed-Score Equating and Levine Observed-Score Equating under the Generalized Kernel Equating Framework

Science.gov (United States)

Chen, Haiwen

2012-01-01

In this article, linear item response theory (IRT) observed-score equating is compared under a generalized kernel equating framework with Levine observed-score equating for nonequivalent groups with anchor test design. Interestingly, these two equating methods are closely related despite being based on different methodologies. Specifically, when…

Synthesis of amino functionalized magnetic graphenes composite material and its application to remove Cr(VI), Pb(II), Hg(II), Cd(II) and Ni(II) from contaminated water

International Nuclear Information System (INIS)

Guo, Xiaoyao; Du, Bin; Wei, Qin; Yang, Jian; Hu, Lihua; Yan, Liangguo; Xu, Weiying

2014-01-01

Highlights: • Graphenes magnetic composite nanoparticles (Fe 3 O 4 -GS) were used to adsorb metal ions. • The adsorption of metal ions onto Fe 3 O 4 -GS could be well interpreted by the Freundlich equation. • The adsorption of metal ions onto Fe 3 O 4 -GS fit pseudo-second order kinetic model. • Thermodynamic studies illustrated that the adsorption process was endothermic and spontaneous in nature. - Abstract: In the present study, a kind of graphenes magnetic material (Fe 3 O 4 -GS) was prepared by compositing graphene sheet with ferroferric oxide, and shown to be effictive for removing Cr(VI), Pb(II), Hg(II), Cd(II) and Ni(II) ions from aqueous solution. The synthesized sorbent was characterized by SEM, TEM, FTIR, XRD, XPS and BET, respectively. The pH ZPC value of the sorbent was estimated to be 3.5 by alkaline-titration methods. Fe 3 O 4 -GS can be simply recovered from water with magnetic separation at low magnetic field within one minute. The sorption capacities of the metals were 17.29, 27.95, 23.03, 27.83 and 22.07 mg g −1 for Cr(VI), Pb(II), Hg(II), Cd(II) and Ni(II), respectively. Kinetic data showed good correlation with pseudo-second-order equation and the Freundlich model was found to fit for the isotherm data of all the heavy metal ions. It was found that the metals sorption was accomplished mainly via chelation or ion exchange. The results of thermodynamic studies illustrate that the adsorption process was endothermic and spontaneous in nature

Five-dimensional Monopole Equation with Hedge-Hog Ansatz and Abel's Differential Equation

OpenAIRE

Kihara, Hironobu

2008-01-01

We review the generalized monopole in the five-dimensional Euclidean space. A numerical solution with the Hedge-Hog ansatz is studied. The Bogomol'nyi equation becomes a second order autonomous non-linear differential equation. The equation can be translated into the Abel's differential equation of the second kind and is an algebraic differential equation.

Differential equations a dynamical systems approach ordinary differential equations

CERN Document Server

Hubbard, John H

1991-01-01

This is a corrected third printing of the first part of the text Differential Equations: A Dynamical Systems Approach written by John Hubbard and Beverly West. The authors' main emphasis in this book is on ordinary differential equations. The book is most appropriate for upper level undergraduate and graduate students in the fields of mathematics, engineering, and applied mathematics, as well as the life sciences, physics and economics. Traditional courses on differential equations focus on techniques leading to solutions. Yet most differential equations do not admit solutions which can be written in elementary terms. The authors have taken the view that a differential equations defines functions; the object of the theory is to understand the behavior of these functions. The tools the authors use include qualitative and numerical methods besides the traditional analytic methods. The companion software, MacMath, is designed to bring these notions to life.

A Fixed-point Scheme for the Numerical Construction of Magnetohydrostatic Atmospheres in Three Dimensions

Science.gov (United States)

Gilchrist, S. A.; Braun, D. C.; Barnes, G.

2016-12-01

Magnetohydrostatic models of the solar atmosphere are often based on idealized analytic solutions because the underlying equations are too difficult to solve in full generality. Numerical approaches, too, are often limited in scope and have tended to focus on the two-dimensional problem. In this article we develop a numerical method for solving the nonlinear magnetohydrostatic equations in three dimensions. Our method is a fixed-point iteration scheme that extends the method of Grad and Rubin ( Proc. 2nd Int. Conf. on Peaceful Uses of Atomic Energy 31, 190, 1958) to include a finite gravity force. We apply the method to a test case to demonstrate the method in general and our implementation in code in particular.

Differential equations

CERN Document Server

Barbu, Viorel

2016-01-01

This textbook is a comprehensive treatment of ordinary differential equations, concisely presenting basic and essential results in a rigorous manner. Including various examples from physics, mechanics, natural sciences, engineering and automatic theory, Differential Equations is a bridge between the abstract theory of differential equations and applied systems theory. Particular attention is given to the existence and uniqueness of the Cauchy problem, linear differential systems, stability theory and applications to first-order partial differential equations. Upper undergraduate students and researchers in applied mathematics and systems theory with a background in advanced calculus will find this book particularly useful. Supplementary topics are covered in an appendix enabling the book to be completely self-contained.

Hyper-resistivity and electron thermal conductivity due to destroyed magnetic surfaces in axisymmetric plasma equilibria

Energy Technology Data Exchange (ETDEWEB)

Weening, R. H. [Department of Radiologic Sciences, Thomas Jefferson University, 901 Walnut Street, Philadelphia, Pennsylvania 19107-5233 (United States)

2012-06-15

In order to model the effects of small-scale current-driven magnetic fluctuations in a mean-field theoretical description of a large-scale plasma magnetic field B(x,t), a space and time dependent hyper-resistivity {Lambda}(x,t) can be incorporated into the Ohm's law for the parallel electric field E Dot-Operator B. Using Boozer coordinates, a theoretical method is presented that allows for a determination of the hyper-resistivity {Lambda}({psi}) functional dependence on the toroidal magnetic flux {psi} for arbitrary experimental steady-state Grad-Shafranov axisymmetric plasma equilibria, if values are given for the parallel plasma resistivity {eta}({psi}) and the local distribution of any auxiliary plasma current. Heat transport in regions of plasma magnetic surfaces destroyed by resistive tearing modes can then be modeled by an electron thermal conductivity k{sub e}({psi})=({epsilon}{sub 0}{sup 2}m{sub e}/e{sup 2}){Lambda}({psi}), where e and m{sub e} are the electron charge and mass, respectively, while {epsilon}{sub 0} is the permittivity of free space. An important result obtained for axisymmetric plasma equilibria is that the {psi}{psi}-component of the metric tensor of Boozer coordinates is given by the relation g{sup {psi}{psi}}({psi}){identical_to}{nabla}{psi} Dot-Operator {nabla}{psi}=[{mu}{sub 0}G({psi})][{mu}{sub 0}I({psi})]/{iota}({psi}), with {mu}{sub 0} the permeability of free space, G({psi}) the poloidal current outside a magnetic surface, I({psi}) the toroidal current inside a magnetic surface, and {iota}({psi}) the rotational transform.

Gyrokinetic neoclassical study of the bootstrap current in the tokamak edge pedestal with fully non-linear Coulomb collisions

Energy Technology Data Exchange (ETDEWEB)

Hager, Robert, E-mail: rhager@pppl.gov; Chang, C. S., E-mail: cschang@pppl.gov [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, New Jersey 08543 (United States)

2016-04-15

As a follow-up on the drift-kinetic study of the non-local bootstrap current in the steep edge pedestal of tokamak plasma by Koh et al. [Phys. Plasmas 19, 072505 (2012)], a gyrokinetic neoclassical study is performed with gyrokinetic ions and drift-kinetic electrons. Besides the gyrokinetic improvement of ion physics from the drift-kinetic treatment, a fully non-linear Fokker-Planck collision operator—that conserves mass, momentum, and energy—is used instead of Koh et al.'s linearized collision operator in consideration of the possibility that the ion distribution function is non-Maxwellian in the steep pedestal. An inaccuracy in Koh et al.'s result is found in the steep edge pedestal that originated from a small error in the collisional momentum conservation. The present study concludes that (1) the bootstrap current in the steep edge pedestal is generally smaller than what has been predicted from the small banana-width (local) approximation [e.g., Sauter et al., Phys. Plasmas 6, 2834 (1999) and Belli et al., Plasma Phys. Controlled Fusion 50, 095010 (2008)], (2) the plasma flow evaluated from the local approximation can significantly deviate from the non-local results, and (3) the bootstrap current in the edge pedestal, where the passing particle region is small, can be dominantly carried by the trapped particles in a broad trapped boundary layer. A new analytic formula based on numerous gyrokinetic simulations using various magnetic equilibria and plasma profiles with self-consistent Grad-Shafranov solutions is constructed.

New Equating Methods and Their Relationships with Levine Observed Score Linear Equating under the Kernel Equating Framework

Science.gov (United States)

Chen, Haiwen; Holland, Paul

2010-01-01

In this paper, we develop a new curvilinear equating for the nonequivalent groups with anchor test (NEAT) design under the assumption of the classical test theory model, that we name curvilinear Levine observed score equating. In fact, by applying both the kernel equating framework and the mean preserving linear transformation of…

Relations between nonlinear Riccati equations and other equations in fundamental physics

International Nuclear Information System (INIS)

Schuch, Dieter

2014-01-01

Many phenomena in the observable macroscopic world obey nonlinear evolution equations while the microscopic world is governed by quantum mechanics, a fundamental theory that is supposedly linear. In order to combine these two worlds in a common formalism, at least one of them must sacrifice one of its dogmas. Linearizing nonlinear dynamics would destroy the fundamental property of this theory, however, it can be shown that quantum mechanics can be reformulated in terms of nonlinear Riccati equations. In a first step, it will be shown that the information about the dynamics of quantum systems with analytical solutions can not only be obtainable from the time-dependent Schrödinger equation but equally-well from a complex Riccati equation. Comparison with supersymmetric quantum mechanics shows that even additional information can be obtained from the nonlinear formulation. Furthermore, the time-independent Schrödinger equation can also be rewritten as a complex Riccati equation for any potential. Extension of the Riccati formulation to include irreversible dissipative effects is straightforward. Via (real and complex) Riccati equations, other fields of physics can also be treated within the same formalism, e.g., statistical thermodynamics, nonlinear dynamical systems like those obeying a logistic equation as well as wave equations in classical optics, Bose- Einstein condensates and cosmological models. Finally, the link to abstract ''quantizations'' such as the Pythagorean triples and Riccati equations connected with trigonometric and hyperbolic functions will be shown

Bridging the Knowledge Gaps between Richards' Equation and Budyko Equation

Science.gov (United States)

Wang, D.

2017-12-01

The empirical Budyko equation represents the partitioning of mean annual precipitation into evaporation and runoff. Richards' equation, based on Darcy's law, represents the movement of water in unsaturated soils. The linkage between Richards' equation and Budyko equation is presented by invoking the empirical Soil Conservation Service curve number (SCS-CN) model for computing surface runoff at the event-scale. The basis of the SCS-CN method is the proportionality relationship, i.e., the ratio of continuing abstraction to its potential is equal to the ratio of surface runoff to its potential value. The proportionality relationship can be derived from the Richards' equation for computing infiltration excess and saturation excess models at the catchment scale. Meanwhile, the generalized proportionality relationship is demonstrated as the common basis of SCS-CN method, monthly "abcd" model, and Budyko equation. Therefore, the linkage between Darcy's law and the emergent pattern of mean annual water balance at the catchment scale is presented through the proportionality relationship.

Partial differential equations

CERN Document Server

Evans, Lawrence C

2010-01-01

This text gives a comprehensive survey of modern techniques in the theoretical study of partial differential equations (PDEs) with particular emphasis on nonlinear equations. The exposition is divided into three parts: representation formulas for solutions; theory for linear partial differential equations; and theory for nonlinear partial differential equations. Included are complete treatments of the method of characteristics; energy methods within Sobolev spaces; regularity for second-order elliptic, parabolic, and hyperbolic equations; maximum principles; the multidimensional calculus of variations; viscosity solutions of Hamilton-Jacobi equations; shock waves and entropy criteria for conservation laws; and, much more.The author summarizes the relevant mathematics required to understand current research in PDEs, especially nonlinear PDEs. While he has reworked and simplified much of the classical theory (particularly the method of characteristics), he primarily emphasizes the modern interplay between funct...

Nonlinear Dirac Equations

Directory of Open Access Journals (Sweden)

Wei Khim Ng

2009-02-01

Full Text Available We construct nonlinear extensions of Dirac's relativistic electron equation that preserve its other desirable properties such as locality, separability, conservation of probability and Poincaré invariance. We determine the constraints that the nonlinear term must obey and classify the resultant non-polynomial nonlinearities in a double expansion in the degree of nonlinearity and number of derivatives. We give explicit examples of such nonlinear equations, studying their discrete symmetries and other properties. Motivated by some previously suggested applications we then consider nonlinear terms that simultaneously violate Lorentz covariance and again study various explicit examples. We contrast our equations and construction procedure with others in the literature and also show that our equations are not gauge equivalent to the linear Dirac equation. Finally we outline various physical applications for these equations.

Detection of high GS risk group prostate tumors by diffusion tensor imaging and logistic regression modelling.

Science.gov (United States)

Ertas, Gokhan

2018-07-01

To assess the value of joint evaluation of diffusion tensor imaging (DTI) measures by using logistic regression modelling to detect high GS risk group prostate tumors. Fifty tumors imaged using DTI on a 3 T MRI device were analyzed. Regions of interests focusing on the center of tumor foci and noncancerous tissue on the maps of mean diffusivity (MD) and fractional anisotropy (FA) were used to extract the minimum, the maximum and the mean measures. Measure ratio was computed by dividing tumor measure by noncancerous tissue measure. Logistic regression models were fitted for all possible pair combinations of the measures using 5-fold cross validation. Systematic differences are present for all MD measures and also for all FA measures in distinguishing the high risk tumors [GS ≥ 7(4 + 3)] from the low risk tumors [GS ≤ 7(3 + 4)] (P Logistic regression modelling provides a favorable solution for the joint evaluations easily adoptable in clinical practice. Copyright © 2018 Elsevier Inc. All rights reserved.

NuSTAR Observations of the Black Hole GS 1354-645: Evidence of Rapid Black Hole Spin

Science.gov (United States)

El-Batal, A. M.; Miller, J. M.; Reynolds, M. T.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Fuerst, F.; Hailey, C. J.; Harrison, F. A.; Stern, D. K.;

Functional equations with causal operators

CERN Document Server

Corduneanu, C

2003-01-01

Functional equations encompass most of the equations used in applied science and engineering: ordinary differential equations, integral equations of the Volterra type, equations with delayed argument, and integro-differential equations of the Volterra type. The basic theory of functional equations includes functional differential equations with causal operators. Functional Equations with Causal Operators explains the connection between equations with causal operators and the classical types of functional equations encountered by mathematicians and engineers. It details the fundamentals of linear equations and stability theory and provides several applications and examples.

Exploring bacterial diversity in hospital environments by GS-FLX Titanium pyrosequencing.

Directory of Open Access Journals (Sweden)

Margarita Poza

Full Text Available Understanding microbial populations in hospital environments is crucial for improving human health. Hospital-acquired infections are an increasing problem in intensive care units (ICU. In this work we present an exploration of bacterial diversity at inanimate surfaces of the ICU wards of the University Hospital A Coruña (Spain, as an example of confined hospital environment subjected to selective pressure, taking the entrance hall of the hospital, an open and crowded environment, as reference. Surface swab samples were collected from both locations and recovered DNA used as template to amplify a hypervariable region of the bacterial 16S rRNA gene. Sequencing of the amplicons was performed at the Roche 454 Sequencing Center using GS-FLX Titanium procedures. Reads were pre-processed and clustered into OTUs (operational taxonomic units, which were further classified. A total of 16 canonical bacterial phyla were detected in both locations. Members of the phyla Firmicutes (mainly Staphylococcus and Streptococcus and Actinobacteria (mainly Micrococcaceae, Corynebacteriaceae and Brevibacteriaceae were over-represented in the ICU with respect to the Hall. The phyllum Proteobacteria was also well represented in the ICU, mainly by members of the families Enterobacteriaceae, Methylobacteriaceae and Sphingomonadaceae. In the Hall sample, the phyla Proteobacteria, Bacteroidetes, Deinococcus-Thermus and Cyanobacteria were over-represented with respect to the ICU. Over-representation of Proteobacteria was mainly due to the high abundance of Enterobacteriaceae members. The presented results demonstrate that bacterial diversity differs at the ICU and entrance hall locations. Reduced diversity detected at ICU, relative to the entrance hall, can be explained by its confined character and by the existence of antimicrobial selective pressure. This is the first study using deep sequencing techniques made in hospital wards showing substantial hospital microbial

Exploring bacterial diversity in hospital environments by GS-FLX Titanium pyrosequencing.

Science.gov (United States)

Poza, Margarita; Gayoso, Carmen; Gómez, Manuel J; Rumbo-Feal, Soraya; Tomás, María; Aranda, Jesús; Fernández, Ana; Bou, Germán

2012-01-01

Understanding microbial populations in hospital environments is crucial for improving human health. Hospital-acquired infections are an increasing problem in intensive care units (ICU). In this work we present an exploration of bacterial diversity at inanimate surfaces of the ICU wards of the University Hospital A Coruña (Spain), as an example of confined hospital environment subjected to selective pressure, taking the entrance hall of the hospital, an open and crowded environment, as reference. Surface swab samples were collected from both locations and recovered DNA used as template to amplify a hypervariable region of the bacterial 16S rRNA gene. Sequencing of the amplicons was performed at the Roche 454 Sequencing Center using GS-FLX Titanium procedures. Reads were pre-processed and clustered into OTUs (operational taxonomic units), which were further classified. A total of 16 canonical bacterial phyla were detected in both locations. Members of the phyla Firmicutes (mainly Staphylococcus and Streptococcus) and Actinobacteria (mainly Micrococcaceae, Corynebacteriaceae and Brevibacteriaceae) were over-represented in the ICU with respect to the Hall. The phyllum Proteobacteria was also well represented in the ICU, mainly by members of the families Enterobacteriaceae, Methylobacteriaceae and Sphingomonadaceae. In the Hall sample, the phyla Proteobacteria, Bacteroidetes, Deinococcus-Thermus and Cyanobacteria were over-represented with respect to the ICU. Over-representation of Proteobacteria was mainly due to the high abundance of Enterobacteriaceae members. The presented results demonstrate that bacterial diversity differs at the ICU and entrance hall locations. Reduced diversity detected at ICU, relative to the entrance hall, can be explained by its confined character and by the existence of antimicrobial selective pressure. This is the first study using deep sequencing techniques made in hospital wards showing substantial hospital microbial diversity.

Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.

Science.gov (United States)

Vandorpe, David H; Xu, Chang; Shmukler, Boris E; Otterbein, Leo E; Trudel, Marie; Sachs, Frederick; Gottlieb, Philip A; Brugnara, Carlo; Alper, Seth L

2010-01-15

Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca(2+)] ([Ca(2+)](i)) and subsequent activation of K(Ca) 3.1. The resulting erythrocyte volume decrease elevates intracellular hemoglobin S (HbSS) concentration, accelerates deoxygenation-induced HbSS polymerization, and increases the likelihood of cell sickling. Deoxygenation-induced currents sharing some properties of Psickle have been recorded from sickle erythrocytes in whole cell configuration. We now show by cell-attached and nystatin-permeabilized patch clamp recording from sickle erythrocytes of mouse and human that deoxygenation reversibly activates a Ca(2+)- and cation-permeable conductance sensitive to inhibition by Grammastola spatulata mechanotoxin-4 (GsMTx-4; 1 microM), dipyridamole (100 microM), DIDS (100 microM), and carbon monoxide (25 ppm pretreatment). Deoxygenation also elevates sickle erythrocyte [Ca(2+)](i), in a manner similarly inhibited by GsMTx-4 and by carbon monoxide. Normal human and mouse erythrocytes do not exhibit these responses to deoxygenation. Deoxygenation-induced elevation of [Ca(2+)](i) in mouse sickle erythrocytes did not require KCa3.1 activity. The electrophysiological and fluorimetric data provide compelling evidence in sickle erythrocytes of mouse and human for a deoxygenation-induced, reversible, Ca(2+)-permeable cation conductance blocked by inhibition of HbSS polymerization and by an inhibitor of strctch-activated cation channels. This cation permeability pathway is likely an important source of intracellular Ca(2+) for pathologic activation of KCa3.1 in sickle erythrocytes. Blockade of this pathway represents a novel therapeutic approach for treatment of sickle disease.

Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.

Directory of Open Access Journals (Sweden)

David H Vandorpe

2010-01-01

Full Text Available Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle, leading to elevated intracellular [Ca(2+] ([Ca(2+](i and subsequent activation of K(Ca 3.1. The resulting erythrocyte volume decrease elevates intracellular hemoglobin S (HbSS concentration, accelerates deoxygenation-induced HbSS polymerization, and increases the likelihood of cell sickling. Deoxygenation-induced currents sharing some properties of Psickle have been recorded from sickle erythrocytes in whole cell configuration.We now show by cell-attached and nystatin-permeabilized patch clamp recording from sickle erythrocytes of mouse and human that deoxygenation reversibly activates a Ca(2+- and cation-permeable conductance sensitive to inhibition by Grammastola spatulata mechanotoxin-4 (GsMTx-4; 1 microM, dipyridamole (100 microM, DIDS (100 microM, and carbon monoxide (25 ppm pretreatment. Deoxygenation also elevates sickle erythrocyte [Ca(2+](i, in a manner similarly inhibited by GsMTx-4 and by carbon monoxide. Normal human and mouse erythrocytes do not exhibit these responses to deoxygenation. Deoxygenation-induced elevation of [Ca(2+](i in mouse sickle erythrocytes did not require KCa3.1 activity.The electrophysiological and fluorimetric data provide compelling evidence in sickle erythrocytes of mouse and human for a deoxygenation-induced, reversible, Ca(2+-permeable cation conductance blocked by inhibition of HbSS polymerization and by an inhibitor of strctch-activated cation channels. This cation permeability pathway is likely an important source of intracellular Ca(2+ for pathologic activation of KCa3.1 in sickle erythrocytes. Blockade of this pathway represents a novel therapeutic approach for treatment of sickle disease.

Evaluating Equating Results: Percent Relative Error for Chained Kernel Equating

Science.gov (United States)

Jiang, Yanlin; von Davier, Alina A.; Chen, Haiwen

2012-01-01

This article presents a method for evaluating equating results. Within the kernel equating framework, the percent relative error (PRE) for chained equipercentile equating was computed under the nonequivalent groups with anchor test (NEAT) design. The method was applied to two data sets to obtain the PRE, which can be used to measure equating…

Using pre-treatment PSA and Gleason score to predict for extra capsular extension among patients with clinically staged organ confined prostate cancer

Energy Technology Data Exchange (ETDEWEB)

Chen, Anita; Roach, Mack; Diaz, Aidnag; Marquez, Carol; Chinn, Dan; Coleman, Lori; Presti, Joseph; Carroll, Peter

1995-07-01

Purpose/Objectives: The patients most suitable for a radical prostatectomy (RP) are those with organ confined disease. At least(1(3)) of patients with clinically staged organ confined disease will be found to have extra capsular extension (ECE) following RP. The purpose of this study is to assess the predictive value of an equation for predicting the risk of ECE based on the pre-treatment prostatic specific antigen (PSA) and Gleason score (GS) in patients with clinical stage T1/T2 prostate cancer. Materials and Methods: Two hundred and twenty-two patients who underwent RP at either the San Francisco VAMC or UCSF between 1988 and 1994 were eligible for this analysis. Patients were considered eligible if the pathological stage, pre-operative PSA and GS were available. Among these patients the median pre-operative PSA was 9 ng/ml (range 0 - 195 ng/ml), and the median pre-operative GS was 6 (range 2-10). The empirically derived equations tested were [1.5 x PSA + (GS - 3) x 10] (Roach, J. Urol., 150: 1923-1924, 1993) as well as a recent modification of this equation of [PSA + (GS - 3.5) x 10]. For these equations, the range of calculated risk was limited to 0 - 100%. Results: The results of using these two equations are shown graphically. Using the modified equation, with a calculated risk (CR) of {<=}25% and an average calculated risk (ACR) of 15.4%, the observed incidence (OI) of ECE was 17.2%. Among the patients with a CR of 26 to 50% and an ACR of 36.1%, the OI of ECE was 38.4%. Among the patients with a CR of 51 to 75% and an ACR of 60.4%, the OI of ECE was 62.7%. Finally, among the patients with a CR of 76 to 100% and an ACR of 77.3%, the OI of ECE was 85.7%. Transrectal ultrasound (TRUS) or magnetic resonance imaging (MRI) reports were available in 72 patients. Correlation with TRUS demonstrated a sensitivity and specificity of 52.4% and 56.1% respectively. Correlation with MRI showed a sensitivity of 57.9% and a specificity of 45.5%. The use of either MRI or

Handbook of integral equations

CERN Document Server

Polyanin, Andrei D

2008-01-01

This handbook contains over 2,500 integral equations with solutions as well as analytical and numerical methods for solving linear and nonlinear equations. It explores Volterra, Fredholm, WienerHopf, Hammerstein, Uryson, and other equations that arise in mathematics, physics, engineering, the sciences, and economics. This second edition includes new chapters on mixed multidimensional equations and methods of integral equations for ODEs and PDEs, along with over 400 new equations with exact solutions. With many examples added for illustrative purposes, it presents new material on Volterra, Fredholm, singular, hypersingular, dual, and nonlinear integral equations, integral transforms, and special functions.

Ordinary differential equations

CERN Document Server

Greenberg, Michael D

2014-01-01

Features a balance between theory, proofs, and examples and provides applications across diverse fields of study Ordinary Differential Equations presents a thorough discussion of first-order differential equations and progresses to equations of higher order. The book transitions smoothly from first-order to higher-order equations, allowing readers to develop a complete understanding of the related theory. Featuring diverse and interesting applications from engineering, bioengineering, ecology, and biology, the book anticipates potential difficulties in understanding the various solution steps

Carbon steel protection in G.S. (Girlder sulfide) plants. Pressure influence on iron sulfide scales formation. Pt. 5

International Nuclear Information System (INIS)

Delfino, C.A.; Lires, O.A.; Rojo, E.A.

1987-01-01

In order to protect carbon steel towers and piping of Girlder sulfide (G.S.) experimental heavy water plants against corrosion produced by the action of aqueous solutions of hydrogen sulfide, a method, previously published, was developed. Carbon steel, exposed to saturated aqueous solutions of hydrogen sulfide, forms iron sulfide scales. In oxygen free solutions evolution of corrosion follows the sequence: mackinawite → cubic ferrous sulfide → troilite → pyrrotite → pyrite. Scales formed by pyrrotite-pyrite or pyrite are the most protective layers (these are obtained at 130 deg C, 2MPa, for periods of 14 days). Experiments, at 125 deg C and periods of 10-25 days, were performed in two different ways: 1- constant pressure operations at 0.5 and 1.1 MPa. 2- variable pressure operation between 0.3-1 MPa. In all cases pyrrotite-pyrite scales were obtained. (Author) [es

Transport barriers in bootstrap-driven tokamaks

Science.gov (United States)

Staebler, G. M.; Garofalo, A. M.; Pan, C.; McClenaghan, J.; Van Zeeland, M. A.; Lao, L. L.

2018-05-01

Experiments have demonstrated improved energy confinement due to the spontaneous formation of an internal transport barrier in high bootstrap fraction discharges. Gyrokinetic analysis, and quasilinear predictive modeling, demonstrates that the observed transport barrier is caused by the suppression of turbulence primarily from the large Shafranov shift. It is shown that the Shafranov shift can produce a bifurcation to improved confinement in regions of positive magnetic shear or a continuous reduction in transport for weak or negative magnetic shear. Operation at high safety factor lowers the pressure gradient threshold for the Shafranov shift-driven barrier formation. Two self-organized states of the internal and edge transport barrier are observed. It is shown that these two states are controlled by the interaction of the bootstrap current with magnetic shear, and the kinetic ballooning mode instability boundary. Election scale energy transport is predicted to be dominant in the inner 60% of the profile. Evidence is presented that energetic particle-driven instabilities could be playing a role in the thermal energy transport in this region.

Fractional Schroedinger equation

International Nuclear Information System (INIS)

Laskin, Nick

2002-01-01

Some properties of the fractional Schroedinger equation are studied. We prove the Hermiticity of the fractional Hamilton operator and establish the parity conservation law for fractional quantum mechanics. As physical applications of the fractional Schroedinger equation we find the energy spectra of a hydrogenlike atom (fractional 'Bohr atom') and of a fractional oscillator in the semiclassical approximation. An equation for the fractional probability current density is developed and discussed. We also discuss the relationships between the fractional and standard Schroedinger equations

Introduction to differential equations

CERN Document Server

Taylor, Michael E

2011-01-01

The mathematical formulations of problems in physics, economics, biology, and other sciences are usually embodied in differential equations. The analysis of the resulting equations then provides new insight into the original problems. This book describes the tools for performing that analysis. The first chapter treats single differential equations, emphasizing linear and nonlinear first order equations, linear second order equations, and a class of nonlinear second order equations arising from Newton's laws. The first order linear theory starts with a self-contained presentation of the exponen

S08: investigation and repair of a cracked feeder at Point Lepreau GS

International Nuclear Information System (INIS)

A Celovsky, A.; Wright, M.D.; Gendron, T.S.

1997-01-01

Early in 1997 investigation of a low level leak in the Point Lepreau GS (PLGS) PHTS revealed that an outlet feeder, S08, was leaking. Ultrasonic inspection, and subsequent failure analysis, revealed that the leak was a consequence of a crack. Given the unusual nature of this event, and current concerns over feeder thinning, a detailed and careful removal and examination procedure was developed. The S08 outlet feeder was removed and shipped to Chalk River Laboratories for examination. The examination confirmed that the failure was a through-wall crack, most likely the consequence of stress corrosion cracking. A critical point of the analysis was to determine how the crack initiated, and subsequently propagated. High residual stresses and possible abnormal loading in conjunction with chemistry environments resulted in the Stress Corrosion Cracking (SCC) of the S08 outlet feeder bend. It is recognized that some of the causative factors implicated in the S08 failure apply to other outlet feeders. In particular, residual stresses in the non-stress-relieved, short-radius cold bent pipes will remain relatively high over the future life of the feeders. However, the risk of CANDU feeder failure by SCC is judged to be extremely low based on the evidence of the inspections carried out to date and the good performance record of feeder pipe in the CANDU industry. The channel was restored to its locked configuration, and the failed section of feeder replaced. (author)

Stochastic optimal control, forward-backward stochastic differential equations and the Schroedinger equation

Energy Technology Data Exchange (ETDEWEB)

Paul, Wolfgang; Koeppe, Jeanette [Institut fuer Physik, Martin Luther Universitaet, 06099 Halle (Germany); Grecksch, Wilfried [Institut fuer Mathematik, Martin Luther Universitaet, 06099 Halle (Germany)

2016-07-01

The standard approach to solve a non-relativistic quantum problem is through analytical or numerical solution of the Schroedinger equation. We show a way to go around it. This way is based on the derivation of the Schroedinger equation from conservative diffusion processes and the establishment of (several) stochastic variational principles leading to the Schroedinger equation under the assumption of a kinematics described by Nelson's diffusion processes. Mathematically, the variational principle can be considered as a stochastic optimal control problem linked to the forward-backward stochastic differential equations of Nelson's stochastic mechanics. The Hamilton-Jacobi-Bellmann equation of this control problem is the Schroedinger equation. We present the mathematical background and how to turn it into a numerical scheme for analyzing a quantum system without using the Schroedinger equation and exemplify the approach for a simple 1d problem.

Averaged RMHD equations

International Nuclear Information System (INIS)

Ichiguchi, Katsuji

1998-01-01

A new reduced set of resistive MHD equations is derived by averaging the full MHD equations on specified flux coordinates, which is consistent with 3D equilibria. It is confirmed that the total energy is conserved and the linearized equations for ideal modes are self-adjoint. (author)

Differential equations

CERN Document Server

Tricomi, FG

2013-01-01

Based on his extensive experience as an educator, F. G. Tricomi wrote this practical and concise teaching text to offer a clear idea of the problems and methods of the theory of differential equations. The treatment is geared toward advanced undergraduates and graduate students and addresses only questions that can be resolved with rigor and simplicity.Starting with a consideration of the existence and uniqueness theorem, the text advances to the behavior of the characteristics of a first-order equation, boundary problems for second-order linear equations, asymptotic methods, and diff

How to obtain the covariant form of Maxwell's equations from the continuity equation

International Nuclear Information System (INIS)

Heras, Jose A

2009-01-01

The covariant Maxwell equations are derived from the continuity equation for the electric charge. This result provides an axiomatic approach to Maxwell's equations in which charge conservation is emphasized as the fundamental axiom underlying these equations

[Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документ�

Index Scriptorium Estoniae

Levans, Andris, 1968-

2011-01-01

Arvustus: Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документы комплекса Moscowitica-Ruthenica об отношениях Смоленска и Риги /koostajad Leksanders Ivanovs, Anatolijs Kuzņcovs. Vēstures avoti ; 6 (Riga: Latvijas Valsts vēstures arcīva izdevniecība, 2009)

A generalized simplest equation method and its application to the Boussinesq-Burgers equation.

Science.gov (United States)

Sudao, Bilige; Wang, Xiaomin

2015-01-01

In this paper, a generalized simplest equation method is proposed to seek exact solutions of nonlinear evolution equations (NLEEs). In the method, we chose a solution expression with a variable coefficient and a variable coefficient ordinary differential auxiliary equation. This method can yield a Bäcklund transformation between NLEEs and a related constraint equation. By dealing with the constraint equation, we can derive infinite number of exact solutions for NLEEs. These solutions include the traveling wave solutions, non-traveling wave solutions, multi-soliton solutions, rational solutions, and other types of solutions. As applications, we obtained wide classes of exact solutions for the Boussinesq-Burgers equation by using the generalized simplest equation method.

On separable Pauli equations

International Nuclear Information System (INIS)

Zhalij, Alexander

2002-01-01

We classify (1+3)-dimensional Pauli equations for a spin-(1/2) particle interacting with the electro-magnetic field, that are solvable by the method of separation of variables. As a result, we obtain the 11 classes of vector-potentials of the electro-magnetic field A(t,x(vector sign))=(A 0 (t,x(vector sign)), A(vector sign)(t,x(vector sign))) providing separability of the corresponding Pauli equations. It is established, in particular, that the necessary condition for the Pauli equation to be separable into second-order matrix ordinary differential equations is its equivalence to the system of two uncoupled Schroedinger equations. In addition, the magnetic field has to be independent of spatial variables. We prove that coordinate systems and the vector-potentials of the electro-magnetic field providing the separability of the corresponding Pauli equations coincide with those for the Schroedinger equations. Furthermore, an efficient algorithm for constructing all coordinate systems providing the separability of Pauli equation with a fixed vector-potential of the electro-magnetic field is developed. Finally, we describe all vector-potentials A(t,x(vector sign)) that (a) provide the separability of Pauli equation, (b) satisfy vacuum Maxwell equations without currents, and (c) describe non-zero magnetic field

Modified Method of Simplest Equation Applied to the Nonlinear Schrödinger Equation

Science.gov (United States)

Vitanov, Nikolay K.; Dimitrova, Zlatinka I.

2018-03-01

We consider an extension of the methodology of the modified method of simplest equation to the case of use of two simplest equations. The extended methodology is applied for obtaining exact solutions of model nonlinear partial differential equations for deep water waves: the nonlinear Schrödinger equation. It is shown that the methodology works also for other equations of the nonlinear Schrödinger kind.

Elliptic and solitary wave solutions for Bogoyavlenskii equations system, couple Boiti-Leon-Pempinelli equations system and Time-fractional Cahn-Allen equation

Directory of Open Access Journals (Sweden)

Mostafa M.A. Khater

Full Text Available In this article and for the first time, we introduce and describe Khater method which is a new technique for solving nonlinear partial differential equations (PDEs.. We apply this method for each of the following models Bogoyavlenskii equation, couple Boiti-Leon-Pempinelli system and Time-fractional Cahn-Allen equation. Khater method is very powerful, Effective, felicitous and fabulous method to get exact and solitary wave solution of (PDEs.. Not only just like that but it considers too one of the general methods for solving that kind of equations since it involves some methods as we will see in our discuss of the results. We make a comparison between the results of this new method and another method. Keywords: Bogoyavlenskii equations system, Couple Boiti-Leon-Pempinelli equations system, Time-fractional Cahn-Allen equation, Khater method, Traveling wave solutions, Solitary wave solutions

Determination of thermal reactivity coefficients for the first fuel loading of MO34

International Nuclear Information System (INIS)

Lueley, J.; Vrban, B.; Farkas, G.; Hascik, J.; Hinca, R.; Petriska, M.; Slugen, V.

2012-01-01

The article introduces determination of thermal reactivity coefficients, especially summarized (isothermal) and moderator (density) reactivity coefficients between 200 grad C and 260 grad C with 2 grad C step, - in compliance with the assignment - for the first fuel loading into the RC of NP Mochovce units using 2 nd generation fuel during the start-up using calculation code MCNP5 1.60. (authors)

Modified Method of Simplest Equation Applied to the Nonlinear Schrödinger Equation

Directory of Open Access Journals (Sweden)

Vitanov Nikolay K.

2018-03-01

Full Text Available We consider an extension of the methodology of the modified method of simplest equation to the case of use of two simplest equations. The extended methodology is applied for obtaining exact solutions of model nonlinear partial differential equations for deep water waves: the nonlinear Schrödinger equation. It is shown that the methodology works also for other equations of the nonlinear Schrödinger kind.

Integrable dissipative nonlinear second order differential equations via factorizations and Abel equations

Energy Technology Data Exchange (ETDEWEB)

Mancas, Stefan C. [Department of Mathematics, Embry–Riddle Aeronautical University, Daytona Beach, FL 32114-3900 (United States); Rosu, Haret C., E-mail: hcr@ipicyt.edu.mx [IPICYT, Instituto Potosino de Investigacion Cientifica y Tecnologica, Apdo Postal 3-74 Tangamanga, 78231 San Luis Potosí, SLP (Mexico)

2013-09-02

We emphasize two connections, one well known and another less known, between the dissipative nonlinear second order differential equations and the Abel equations which in their first-kind form have only cubic and quadratic terms. Then, employing an old integrability criterion due to Chiellini, we introduce the corresponding integrable dissipative equations. For illustration, we present the cases of some integrable dissipative Fisher, nonlinear pendulum, and Burgers–Huxley type equations which are obtained in this way and can be of interest in applications. We also show how to obtain Abel solutions directly from the factorization of second order nonlinear equations.

On the Existence and the Applications of Modified Equations for Stochastic Differential Equations

KAUST Repository

Zygalakis, K. C.

2011-01-01

In this paper we describe a general framework for deriving modified equations for stochastic differential equations (SDEs) with respect to weak convergence. Modified equations are derived for a variety of numerical methods, such as the Euler or the Milstein method. Existence of higher order modified equations is also discussed. In the case of linear SDEs, using the Gaussianity of the underlying solutions, we derive an SDE which the numerical method solves exactly in the weak sense. Applications of modified equations in the numerical study of Langevin equations is also discussed. © 2011 Society for Industrial and Applied Mathematics.

An Auxiliary Equation for the Bellman Equation in a One-Dimensional Ergodic Control

International Nuclear Information System (INIS)

Fujita, Y.

2001-01-01

In this paper we consider the Bellman equation in a one-dimensional ergodic control. Our aim is to show the existence and the uniqueness of its solution under general assumptions. For this purpose we introduce an auxiliary equation whose solution gives the invariant measure of the diffusion corresponding to an optimal control. Using this solution, we construct a solution to the Bellman equation. Our method of using this auxiliary equation has two advantages in the one-dimensional case. First, we can solve the Bellman equation under general assumptions. Second, this auxiliary equation gives an optimal Markov control explicitly in many examples

Covariant field equations in supergravity

Energy Technology Data Exchange (ETDEWEB)

Vanhecke, Bram [KU Leuven, Institute for Theoretical Physics, Leuven (Belgium); Ghent University, Faculty of Physics, Gent (Belgium); Proeyen, Antoine van [KU Leuven, Institute for Theoretical Physics, Leuven (Belgium)

2017-12-15

Covariance is a useful property for handling supergravity theories. In this paper, we prove a covariance property of supergravity field equations: under reasonable conditions, field equations of supergravity are covariant modulo other field equations. We prove that for any supergravity there exist such covariant equations of motion, other than the regular equations of motion, that are equivalent to the latter. The relations that we find between field equations and their covariant form can be used to obtain multiplets of field equations. In practice, the covariant field equations are easily found by simply covariantizing the ordinary field equations. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Covariant field equations in supergravity

International Nuclear Information System (INIS)

Vanhecke, Bram; Proeyen, Antoine van

2017-01-01

Covariance is a useful property for handling supergravity theories. In this paper, we prove a covariance property of supergravity field equations: under reasonable conditions, field equations of supergravity are covariant modulo other field equations. We prove that for any supergravity there exist such covariant equations of motion, other than the regular equations of motion, that are equivalent to the latter. The relations that we find between field equations and their covariant form can be used to obtain multiplets of field equations. In practice, the covariant field equations are easily found by simply covariantizing the ordinary field equations. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Reduction of lattice equations to the Painlevé equations: PIV and PV

Science.gov (United States)

Nakazono, Nobutaka

2018-02-01

In this paper, we construct a new relation between Adler-Bobenko-Suris equations and Painlevé equations. Moreover, using this connection we construct the difference-differential Lax representations of the fourth and fifth Painlevé equations.

Ideal Gas Laws: Experiments for General Chemistry

Science.gov (United States)

Deal, Walter J.

1975-01-01

Describes a series of experiments designed to verify the various relationships implicit in the ideal gas equation and shows that the success of the Graham's law effusion experiments can be explained by elementary hydrodynamics. (GS)

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

Science.gov (United States)

Navarro, Gemma; Cordomí, Arnau; Zelman-Femiak, Monika; Brugarolas, Marc; Moreno, Estefania; Aguinaga, David; Perez-Benito, Laura; Cortés, Antoni; Casadó, Vicent; Mallol, Josefa; Canela, Enric I; Lluís, Carme; Pardo, Leonardo; García-Sáez, Ana J; McCormick, Peter J; Franco, Rafael

2016-04-05

G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways. Different GPCRs may also interact to form heteromers that are novel signaling units. Despite the exponential growth in the number of solved GPCR crystal structures, the structural properties of heteromers remain unknown. We used single-particle tracking experiments in cells expressing functional adenosine A1-A2A receptors fused to fluorescent proteins to show the loss of Brownian movement of the A1 receptor in the presence of the A2A receptor, and a preponderance of cell surface 2:2 receptor heteromers (dimer of dimers). Using computer modeling, aided by bioluminescence resonance energy transfer assays to monitor receptor homomerization and heteromerization and G-protein coupling, we predict the interacting interfaces and propose a quaternary structure of the GPCR tetramer in complex with two G proteins. The combination of results points to a molecular architecture formed by a rhombus-shaped heterotetramer, which is bound to two different interacting heterotrimeric G proteins (Gi and Gs). These novel results constitute an important advance in understanding the molecular intricacies involved in GPCR function.

Measurement of isotope abundance variations in nature by gravimetric spiking isotope dilution analysis (GS-IDA).

Science.gov (United States)

Chew, Gina; Walczyk, Thomas

2013-04-02

Subtle variations in the isotopic composition of elements carry unique information about physical and chemical processes in nature and are now exploited widely in diverse areas of research. Reliable measurement of natural isotope abundance variations is among the biggest challenges in inorganic mass spectrometry as they are highly sensitive to methodological bias. For decades, double spiking of the sample with a mix of two stable isotopes has been considered the reference technique for measuring such variations both by multicollector-inductively coupled plasma mass spectrometry (MC-ICPMS) and multicollector-thermal ionization mass spectrometry (MC-TIMS). However, this technique can only be applied to elements having at least four stable isotopes. Here we present a novel approach that requires measurement of three isotope signals only and which is more robust than the conventional double spiking technique. This became possible by gravimetric mixing of the sample with an isotopic spike in different proportions and by applying principles of isotope dilution for data analysis (GS-IDA). The potential and principle use of the technique is demonstrated for Mg in human urine using MC-TIMS for isotopic analysis. Mg is an element inaccessible to double spiking methods as it consists of three stable isotopes only and shows great potential for metabolically induced isotope effects waiting to be explored.

Test equating methods and practices

CERN Document Server

Kolen, Michael J

1995-01-01

In recent years, many researchers in the psychology and statistical communities have paid increasing attention to test equating as issues of using multiple test forms have arisen and in response to criticisms of traditional testing techniques This book provides a practically oriented introduction to test equating which both discusses the most frequently used equating methodologies and covers many of the practical issues involved The main themes are - the purpose of equating - distinguishing between equating and related methodologies - the importance of test equating to test development and quality control - the differences between equating properties, equating designs, and equating methods - equating error, and the underlying statistical assumptions for equating The authors are acknowledged experts in the field, and the book is based on numerous courses and seminars they have presented As a result, educators, psychometricians, professionals in measurement, statisticians, and students coming to the subject for...

Classical parallel transport in a multi-species plasma from a 21 moment approximation

International Nuclear Information System (INIS)

Radford, G.J.

1993-11-01

Momentum equations from a 21 moment Grad approximation are presented, including full expressions for the collision terms for the case of elastic collisions. Collision terms for the particular case of an electron-ion-impurity plasma are then given. In addition, for the positive ions, approximations to the collision terms are given for a common ion temperature, T z = T i , and a massive impurity species, m z >> m i and general temperatures. The moment equations are solved for the classical parallel transport coefficients for the specific case of a low impurity density plasma and the results compared with those give by other authors. The range of forms for the collision terms is given to allow more general or other types of solutions to be obtained. (Author)

On generalized fractional vibration equation

International Nuclear Information System (INIS)

Dai, Hongzhe; Zheng, Zhibao; Wang, Wei

2017-01-01

Highlights: • The paper presents a generalized fractional vibration equation for arbitrary viscoelastically damped system. • Some classical vibration equations can be derived from the developed equation. • The analytic solution of developed equation is derived under some special cases. • The generalized equation is particularly useful for developing new fractional equivalent linearization method. - Abstract: In this paper, a generalized fractional vibration equation with multi-terms of fractional dissipation is developed to describe the dynamical response of an arbitrary viscoelastically damped system. It is shown that many classical equations of motion, e.g., the Bagley–Torvik equation, can be derived from the developed equation. The Laplace transform is utilized to solve the generalized equation and the analytic solution under some special cases is derived. Example demonstrates the generalized transfer function of an arbitrary viscoelastic system.

Differential equations for dummies

CERN Document Server

Holzner, Steven

2008-01-01

The fun and easy way to understand and solve complex equations Many of the fundamental laws of physics, chemistry, biology, and economics can be formulated as differential equations. This plain-English guide explores the many applications of this mathematical tool and shows how differential equations can help us understand the world around us. Differential Equations For Dummies is the perfect companion for a college differential equations course and is an ideal supplemental resource for other calculus classes as well as science and engineering courses. It offers step-by-step techniques, practical tips, numerous exercises, and clear, concise examples to help readers improve their differential equation-solving skills and boost their test scores.

Every Equation Tells a Story: Using Equation Dictionaries in Introductory Geophysics

Science.gov (United States)

Caplan-Auerbach, Jacqueline

2009-01-01

Many students view equations as a series of variables and operators into which numbers should be plugged rather than as representative of a physical process. To solve a problem they may simply look for an equation with the correct variables and assume it meets their needs, rather than selecting an equation that represents the appropriate physical…

Lean i Norge : opplever norske bedrifter som er mer lean, større økning i kundetilfredshet enn de som er mindre lean?

OpenAIRE

Fagereng, Hanne Eline; Askevold, Elisabeth Cathrine

2010-01-01

Vi ønsker å måle i hvor stor grad norske bedrifter har implementert lean, og for å måle grad av lean har vi utviklet et rammeverk basert på lean teori. Hovedformålet med lean er å øke kundeverdi med minst mulig ressursbruk, anstrengelse, energi, utstyr, tid, plass, material og kapital (Womack, Roos and Jones 2007). Vi vil utforske om høyere grad av lean fører til mer tilfredse kunder enn de som har lavere grad av lean. Altså om hovedformålet med lean blir oppnådd hvis man implementerer lean i...

Fundamental equations for two-phase flow. Part 1: general conservation equations. Part 2: complement and remarks; Equations fondamentales des ecoulements diphasiques. Premiere partie: equations generales de conservation. Deuxieme partie: complements et remarques

Energy Technology Data Exchange (ETDEWEB)

Delhaye, J M [Commissariat a l' Energie Atomique, 38 - Grenoble (France). Centre d' Etudes Nucleaires

1968-12-01

This report deals with the general equations of mass conservation, of momentum conservation, and energy conservation in the case of a two-phase flow. These equations are presented in several forms starting from integral equations which are assumed initially a priori. 1. Equations with local instantaneous variables, and interfacial conditions; 2. Equations with mean instantaneous variables in a cross-section, and practical applications: these equations include an important experimental value which is the ratio of the cross-section of passage of one phase to the total cross-section of a flow-tube. 3. Equations with a local statistical mean, and equations averaged over a period of time: A more advanced attempt to relate theory and experiment consists in taking the statistical averages of local equations. Equations are then obtained involving variables which are averaged over a period of time with the help of an ergodic assumption. 4. Combination of statistical averages and averages over a cross-section: in this study are considered the local variables averaged statistically, then averaged over the cross-section, and also the variables averaged over the section and then averaged statistically. 5. General equations concerning emulsions: In this case a phase exists in a locally very finely divided form. This peculiarity makes it possible to define a volume concentration, and to draw up equations which have numerous applications. - Certain points arising in the first part of this report concerning general mass conservation equations for two-phase flow have been completed and clarified. The terms corresponding to the interfacial tension have been introduced into the general equations. The interfacial conditions have thus been generalized. A supplementary step has still to be carried out: it has, in effect, been impossible to take the interfacial tension into account in the case of emulsions. It was then appeared interesting to compare this large group of fundamental

Fundamental equations for two-phase flow. Part 1: general conservation equations. Part 2: complement and remarks; Equations fondamentales des ecoulements diphasiques. Premiere partie: equations generales de conservation. Deuxieme partie: complements et remarques

Energy Technology Data Exchange (ETDEWEB)

Delhaye, J.M. [Commissariat a l' Energie Atomique, 38 - Grenoble (France). Centre d' Etudes Nucleaires

1968-12-01

This report deals with the general equations of mass conservation, of momentum conservation, and energy conservation in the case of a two-phase flow. These equations are presented in several forms starting from integral equations which are assumed initially a priori. 1. Equations with local instantaneous variables, and interfacial conditions; 2. Equations with mean instantaneous variables in a cross-section, and practical applications: these equations include an important experimental value which is the ratio of the cross-section of passage of one phase to the total cross-section of a flow-tube. 3. Equations with a local statistical mean, and equations averaged over a period of time: A more advanced attempt to relate theory and experiment consists in taking the statistical averages of local equations. Equations are then obtained involving variables which are averaged over a period of time with the help of an ergodic assumption. 4. Combination of statistical averages and averages over a cross-section: in this study are considered the local variables averaged statistically, then averaged over the cross-section, and also the variables averaged over the section and then averaged statistically. 5. General equations concerning emulsions: In this case a phase exists in a locally very finely divided form. This peculiarity makes it possible to define a volume concentration, and to draw up equations which have numerous applications. - Certain points arising in the first part of this report concerning general mass conservation equations for two-phase flow have been completed and clarified. The terms corresponding to the interfacial tension have been introduced into the general equations. The interfacial conditions have thus been generalized. A supplementary step has still to be carried out: it has, in effect, been impossible to take the interfacial tension into account in the case of emulsions. It was then appeared interesting to compare this large group of fundamental

Equating TIMSS Mathematics Subtests with Nonlinear Equating Methods Using NEAT Design: Circle-Arc Equating Approaches

Science.gov (United States)

Ozdemir, Burhanettin

2017-01-01

The purpose of this study is to equate Trends in International Mathematics and Science Study (TIMSS) mathematics subtest scores obtained from TIMSS 2011 to scores obtained from TIMSS 2007 form with different nonlinear observed score equating methods under Non-Equivalent Anchor Test (NEAT) design where common items are used to link two or more test…

The NASA competitive placement plan for positions GS-15 and below (including trades and labor positions)

Science.gov (United States)

1993-01-01

This plan provides the framework for selection based on merit from among the best qualified candidates available. Selections will be made without regard to political, religious, or labor organization affiliation or nonaffiliation, marital status, race, color, sex, national origin, nondisqualifying disability, or age. This plan does not guarantee promotion but rather ensures that all qualified available candidates receive fair and equitable consideration for positions filled under these competitive procedures. Announcing a vacancy under this plan is only one method of locating applicants for a position and can be used in conjunction with other methods. Subject to applicable law and regulation, selection of an individual to fill a position is the decision of management, as is the decision as to the method(s) to be used in identifying candidates. This plan is applicable to all NASA Installations. It covers all positions in the competitive service at (and below) the GS/GM-15 level (including all trades and labor positions), except positions in the Office of the Inspector General. The requirements herein are not intended to, nor should they be construed to limit in any way, the independent personnel authority of the Inspector General under the Inspector General Act, as Amended.

Exciting Pools

Science.gov (United States)

Wright, Bradford L.

1975-01-01

Advocates the creation of swimming pool oscillations as part of a general investigation of mechanical oscillations. Presents the equations, procedure for deriving the slosh modes, and methods of period estimation for exciting swimming pool oscillations. (GS)

Solving polynomial differential equations by transforming them to linear functional-differential equations

OpenAIRE

Nahay, John Michael

2008-01-01

We present a new approach to solving polynomial ordinary differential equations by transforming them to linear functional equations and then solving the linear functional equations. We will focus most of our attention upon the first-order Abel differential equation with two nonlinear terms in order to demonstrate in as much detail as possible the computations necessary for a complete solution. We mention in our section on further developments that the basic transformation idea can be generali...

Lorentz-force equations as Heisenberg equations for a quantum system in the euclidean space

International Nuclear Information System (INIS)

Rodriguez D, R.

2007-01-01

In an earlier work, the dynamic equations for a relativistic charged particle under the action of electromagnetic fields were formulated by R. Yamaleev in terms of external, as well as internal momenta. Evolution equations for external momenta, the Lorentz-force equations, were derived from the evolution equations for internal momenta. The mapping between the observables of external and internal momenta are related by Viete formulae for a quadratic polynomial, the characteristic polynomial of the relativistic dynamics. In this paper we show that the system of dynamic equations, can be cast into the Heisenberg scheme for a four-dimensional quantum system. Within this scheme the equations in terms of internal momenta play the role of evolution equations for a state vector, whereas the external momenta obey the Heisenberg equation for an operator evolution. The solutions of the Lorentz-force equation for the motion inside constant electromagnetic fields are presented via pentagonometric functions. (Author)

Differential Equation over Banach Algebra

OpenAIRE

Kleyn, Aleks

2018-01-01

In the book, I considered differential equations of order $1$ over Banach $D$-algebra: differential equation solved with respect to the derivative; exact differential equation; linear homogeneous equation. In noncommutative Banach algebra, initial value problem for linear homogeneous equation has infinitely many solutions.

Phase diagrams of Pr-C system

International Nuclear Information System (INIS)

Eremenko, V.N.; Velikanova, T.Ya.; Gordijchuk, O.V.

1988-01-01

Results of the X-ray phase, metallographic and high-temperature differential thermal analysis are used for the first time to plot a diagram of the Pr-C system state. Carbides are formed in the system: Pr 2 C 3 with the bcc-structure of the Pu 2 C 3 type and with the period a 0 = 0.85722+-0.00026 within the phase region + 2 C 3 >, a 0 0.86078+-0.00016 nm - within the region 2 C 3 >+α-PrC 2 ; dimorphous PrC 2 : α-PrC 2 with the bct-structure of the CaC 2 type and periods a 0.38517+-0.00011, c 0 = 0.64337+-0.00019 nm; β-PrC 2 with the fcc-structure, probably, of KCN type. Dicarbide melts congruently at 2320 grad. C, forming eutectics with graphite at 2254+-6 grad. C and composition of 71.5% (at.)C. It is polymorphously transformed in the phase region 2 C 3 > + 2 > at 1145+-4 grad. C, and in the region 2 >+C at 1134+-4 grad. C. Sesquicarbide melts incongruently at 1545+-4 grad. C. The eutectic reaction L ↔ + 2 C 3 > occurs at 800+-4 grad. C, the eutectic composition ∼ 15% (at.)C. The temperature of the eutectoid reaction ↔ + 2 C 3 > is 675+-6 grad C. The limiting carbon solubility in β-Pr is about 8 and in α-Pr it is about 5% (at.)

Elements of partial differential equations

CERN Document Server

Sneddon, Ian Naismith

1957-01-01

Geared toward students of applied rather than pure mathematics, this volume introduces elements of partial differential equations. Its focus is primarily upon finding solutions to particular equations rather than general theory.Topics include ordinary differential equations in more than two variables, partial differential equations of the first and second orders, Laplace's equation, the wave equation, and the diffusion equation. A helpful Appendix offers information on systems of surfaces, and solutions to the odd-numbered problems appear at the end of the book. Readers pursuing independent st

New exact solutions to MKDV-Burgers equation and (2 + 1)-dimensional dispersive long wave equation via extended Riccati equation method

International Nuclear Information System (INIS)

Kong Cuicui; Wang Dan; Song Lina; Zhang Hongqing

2009-01-01

In this paper, with the aid of symbolic computation and a general ansaetz, we presented a new extended rational expansion method to construct new rational formal exact solutions to nonlinear partial differential equations. In order to illustrate the effectiveness of this method, we apply it to the MKDV-Burgers equation and the (2 + 1)-dimensional dispersive long wave equation, then several new kinds of exact solutions are successfully obtained by using the new ansaetz. The method can also be applied to other nonlinear partial differential equations.

Introduction to partial differential equations

CERN Document Server

Greenspan, Donald

2000-01-01

Designed for use in a one-semester course by seniors and beginning graduate students, this rigorous presentation explores practical methods of solving differential equations, plus the unifying theory underlying the mathematical superstructure. Topics include basic concepts, Fourier series, second-order partial differential equations, wave equation, potential equation, heat equation, approximate solution of partial differential equations, and more. Exercises appear at the ends of most chapters. 1961 edition.

A New Fractional Projective Riccati Equation Method for Solving Fractional Partial Differential Equations

International Nuclear Information System (INIS)

Feng Qing-Hua

2014-01-01

In this paper, a new fractional projective Riccati equation method is proposed to establish exact solutions for fractional partial differential equations in the sense of modified Riemann—Liouville derivative. This method can be seen as the fractional version of the known projective Riccati equation method. For illustrating the validity of this method, we apply this method to solve the space-time fractional Whitham—Broer—Kaup (WBK) equations and the nonlinear fractional Sharma—Tasso—Olever (STO) equation, and as a result, some new exact solutions for them are obtained. (general)

A new sine-Gordon equation expansion algorithm to investigate some special nonlinear differential equations

International Nuclear Information System (INIS)

Yan Zhenya

2005-01-01

A new transformation method is developed using the general sine-Gordon travelling wave reduction equation and a generalized transformation. With the aid of symbolic computation, this method can be used to seek more types of solutions of nonlinear differential equations, which include not only the known solutions derived by some known methods but new solutions. Here we choose the double sine-Gordon equation, the Magma equation and the generalized Pochhammer-Chree (PC) equation to illustrate the method. As a result, many types of new doubly periodic solutions are obtained. Moreover when using the method to these special nonlinear differential equations, some transformations are firstly needed. The method can be also extended to other nonlinear differential equations

Singular stochastic differential equations

CERN Document Server

Cherny, Alexander S

2005-01-01

The authors introduce, in this research monograph on stochastic differential equations, a class of points termed isolated singular points. Stochastic differential equations possessing such points (called singular stochastic differential equations here) arise often in theory and in applications. However, known conditions for the existence and uniqueness of a solution typically fail for such equations. The book concentrates on the study of the existence, the uniqueness, and, what is most important, on the qualitative behaviour of solutions of singular stochastic differential equations. This is done by providing a qualitative classification of isolated singular points, into 48 possible types.

Reactimeter dispersion equation

OpenAIRE

A.G. Yuferov

2016-01-01

The aim of this work is to derive and analyze a reactimeter metrological model in the form of the dispersion equation which connects reactimeter input/output signal dispersions with superimposed random noise at the inlet. It is proposed to standardize the reactimeter equation form, presenting the main reactimeter computing unit by a convolution equation. Hence, the reactimeter metrological characteristics are completely determined by this unit hardware function which represents a transient re...

Amifostine - a radioprotector in locally advanced head and neck tumors

Energy Technology Data Exchange (ETDEWEB)

Schoenekaes, K.G.; Wagner, W. [Paracelsus-Strahlenklinik, Osnabrueck (Germany); Prott, F.J. [Muenster Univ. (Germany). Inst. fuer Strahlenonkologie

1999-11-01

Purpose: There are some preliminary informations about the beneficial use of amifostine in avoiding side effects in patients with head and neck tumors who underwent radiotherapy. Patients and method: Amifostine was given as daily intravenous application (500 mg) 10 to 15 minutes prior to radiotherapy in 20 patients. The results were compared with another collective of patients which was similar. Results: According to the WHO score mucositis became manifest in 10 patients (Grade I) and 4 patients (Grade II) in the amifostine group vs 9 patients (Grade II), 6 patients (Grade III) and 1 patient (Grade IV) in the control group. Xerostomia has been seen in 15 patients (Grade I) and 5 patients (Grade II) after administration of amifostine. Without the drug 2 patients suffered from xerostomia (Grade I), 8 patients (Grade II) and 8 patients (Grade III), respectively. Administering amifostine had been feasible and non problematic. Only a small rate of toxic side effects like nausea (11%) or emesis (4%) was documented. Conclusions: Amifostine is an effective radioprotector decreasing acute and late side effects in patients with head and neck tumors. (orig.) [German] Zielsetzung: Bisher gibt es nur wenige Informationen ueber den Nutzen von Amifostin bezueglich der Verminderung oder Vermeidung von Nebenwirkungen einer Radiatio bei Patienten mit Tumoren im HNO-Trakt. Patienten und Methode: Amifostin wurde als intravenoese Kurzinfusion mit einer Dosis von 500 mg zehn bis 15 Minuten vor der Bestrahlung bei 20 Patienten appliziert. Die unter Radiatio aufgetretenen Nebenwirkungen wurden nach WHO bzw. nach dem Oral Assessment Guide nach Eilers ausgewertet und mit einem entsprechenden historischen Kollektiv der Klinik verglichen. Ergebnisse: In der Amifostin-Gruppe wurde bei zehn Patienten eine Mukositis Grad I und bei vier Patienten eine Mukositis Grad II nach WHO beobachtet. Grad-III- und Grad-IV-Nebenwirkungen traten nicht auf. In der Kontrollgruppe waren dagegen bei neun

Symmetries and Invariants of the Time-dependent Oscillator Equation and the Envelope Equation

CERN Document Server

Qin, Hong

2005-01-01

Single-particle dynamics in a time-dependent focusing field is examined. The existence of the Courant-Snyder invariant* is fundamentally the result of the corresponding symmetry admitted by the oscillator equation with time-dependent frequency.** A careful analysis of the admitted symmetries reveals a deeper connection between the nonlinear envelope equation and the oscillator equation. A general theorem regarding the symmetries and invariants of the envelope equation, which includes the existence of the Courant-Snyder invariant as a special case, is demonstrated. The symmetries of the envelope equation enable a fast algorithm for finding matched solutions without using the conventional iterative shooting method.

A generalized fractional sub-equation method for fractional differential equations with variable coefficients

International Nuclear Information System (INIS)

Tang, Bo; He, Yinnian; Wei, Leilei; Zhang, Xindong

2012-01-01

In this Letter, a generalized fractional sub-equation method is proposed for solving fractional differential equations with variable coefficients. Being concise and straightforward, this method is applied to the space–time fractional Gardner equation with variable coefficients. As a result, many exact solutions are obtained including hyperbolic function solutions, trigonometric function solutions and rational solutions. It is shown that the considered method provides a very effective, convenient and powerful mathematical tool for solving many other fractional differential equations in mathematical physics. -- Highlights: ► Study of fractional differential equations with variable coefficients plays a role in applied physical sciences. ► It is shown that the proposed algorithm is effective for solving fractional differential equations with variable coefficients. ► The obtained solutions may give insight into many considerable physical processes.

True amplitude wave equation migration arising from true amplitude one-way wave equations

Science.gov (United States)

Zhang, Yu; Zhang, Guanquan; Bleistein, Norman

2003-10-01

One-way wave operators are powerful tools for use in forward modelling and inversion. Their implementation, however, involves introduction of the square root of an operator as a pseudo-differential operator. Furthermore, a simple factoring of the wave operator produces one-way wave equations that yield the same travel times as the full wave equation, but do not yield accurate amplitudes except for homogeneous media and for almost all points in heterogeneous media. Here, we present augmented one-way wave equations. We show that these equations yield solutions for which the leading order asymptotic amplitude as well as the travel time satisfy the same differential equations as the corresponding functions for the full wave equation. Exact representations of the square-root operator appearing in these differential equations are elusive, except in cases in which the heterogeneity of the medium is independent of the transverse spatial variables. Here, we address the fully heterogeneous case. Singling out depth as the preferred direction of propagation, we introduce a representation of the square-root operator as an integral in which a rational function of the transverse Laplacian appears in the integrand. This allows us to carry out explicit asymptotic analysis of the resulting one-way wave equations. To do this, we introduce an auxiliary function that satisfies a lower dimensional wave equation in transverse spatial variables only. We prove that ray theory for these one-way wave equations leads to one-way eikonal equations and the correct leading order transport equation for the full wave equation. We then introduce appropriate boundary conditions at z = 0 to generate waves at depth whose quotient leads to a reflector map and an estimate of the ray theoretical reflection coefficient on the reflector. Thus, these true amplitude one-way wave equations lead to a 'true amplitude wave equation migration' (WEM) method. In fact, we prove that applying the WEM imaging condition

Wind Speed and Sea State Dependencies of Air-Sea Gas Transfer: Results From the High Wind Speed Gas Exchange Study (HiWinGS)

Science.gov (United States)

Blomquist, B. W.; Brumer, S. E.; Fairall, C. W.; Huebert, B. J.; Zappa, C. J.; Brooks, I. M.; Yang, M.; Bariteau, L.; Prytherch, J.; Hare, J. E.; Czerski, H.; Matei, A.; Pascal, R. W.

2017-10-01

A variety of physical mechanisms are jointly responsible for facilitating air-sea gas transfer through turbulent processes at the atmosphere-ocean interface. The nature and relative importance of these mechanisms evolves with increasing wind speed. Theoretical and modeling approaches are advancing, but the limited quantity of observational data at high wind speeds hinders the assessment of these efforts. The HiWinGS project successfully measured gas transfer coefficients (k660) with coincident wave statistics under conditions with hourly mean wind speeds up to 24 m s-1 and significant wave heights to 8 m. Measurements of k660 for carbon dioxide (CO2) and dimethylsulfide (DMS) show an increasing trend with respect to 10 m neutral wind speed (U10N), following a power law relationship of the form: k660 CO2˜U10N1.68 and k660 dms˜U10N1.33. Among seven high wind speed events, CO2 transfer responded to the intensity of wave breaking, which depended on both wind speed and sea state in a complex manner, with k660 CO2 increasing as the wind sea approaches full development. A similar response is not observed for DMS. These results confirm the importance of breaking waves and bubble injection mechanisms in facilitating CO2 transfer. A modified version of the Coupled Ocean-Atmosphere Response Experiment Gas transfer algorithm (COAREG ver. 3.5), incorporating a sea state-dependent calculation of bubble-mediated transfer, successfully reproduces the mean trend in observed k660 with wind speed for both gases. Significant suppression of gas transfer by large waves was not observed during HiWinGS, in contrast to results from two prior field programs.

First-order partial differential equations

CERN Document Server

Rhee, Hyun-Ku; Amundson, Neal R

2001-01-01

This first volume of a highly regarded two-volume text is fully usable on its own. After going over some of the preliminaries, the authors discuss mathematical models that yield first-order partial differential equations; motivations, classifications, and some methods of solution; linear and semilinear equations; chromatographic equations with finite rate expressions; homogeneous and nonhomogeneous quasilinear equations; formation and propagation of shocks; conservation equations, weak solutions, and shock layers; nonlinear equations; and variational problems. Exercises appear at the end of mo

Equating Multidimensional Tests under a Random Groups Design: A Comparison of Various Equating Procedures

Science.gov (United States)

Lee, Eunjung

2013-01-01

The purpose of this research was to compare the equating performance of various equating procedures for the multidimensional tests. To examine the various equating procedures, simulated data sets were used that were generated based on a multidimensional item response theory (MIRT) framework. Various equating procedures were examined, including…

Comparing the IRT Pre-equating and Section Pre-equating: A Simulation Study.

Science.gov (United States)

Hwang, Chi-en; Cleary, T. Anne

The results obtained from two basic types of pre-equatings of tests were compared: the item response theory (IRT) pre-equating and section pre-equating (SPE). The simulated data were generated from a modified three-parameter logistic model with a constant guessing parameter. Responses of two replication samples of 3000 examinees on two 72-item…

Control strategy for plasma equilibrium in a tokamak

International Nuclear Information System (INIS)

Miskell, R.V.

1975-01-01

The dynamic control of the plasma position within the torus of a Tokamak fusion device is a significant factor in the development of nuclear fusion as an energy source. This investigation develops a state variable model of a TOKAMAK thermonuclear device, suitable for application of modern control theory techniques. The model considers eddy currents in the conducting shell surrounding the torus and the classical Shafranov equilibrium equation. The equations necessary to characterize the operating conditions of a TOKAMAK are cast in state variable form. Two control variables are selected, the vertical field current and the plasma temperature. The figure of merit chosen minimizes the shift of the plasma within the torus and considers position perturbations necessary to maintain the dense and hotter portions of the plasma profile in the center of the torus, i.e., overcome uneven poloidal fields due to the toroidal geometry. The model uses a Kalman filter to estimate unmeasured state variables, and uses the second variation of the calculus of variations to maintain an optimal control path. (Diss. Abstr. Int., B)

Beginning partial differential equations

CERN Document Server

O'Neil, Peter V

2014-01-01

A broad introduction to PDEs with an emphasis on specialized topics and applications occurring in a variety of fields Featuring a thoroughly revised presentation of topics, Beginning Partial Differential Equations, Third Edition provides a challenging, yet accessible,combination of techniques, applications, and introductory theory on the subjectof partial differential equations. The new edition offers nonstandard coverageon material including Burger's equation, the telegraph equation, damped wavemotion, and the use of characteristics to solve nonhomogeneous problems. The Third Edition is or

A new formulation of equations of compressible fluids by analogy with Maxwell's equations

International Nuclear Information System (INIS)

Kambe, Tsutomu

2010-01-01

A compressible ideal fluid is governed by Euler's equation of motion and equations of continuity, entropy and vorticity. This system can be reformulated in a form analogous to that of electromagnetism governed by Maxwell's equations with source terms. The vorticity plays the role of magnetic field, while the velocity field plays the part of a vector potential and the enthalpy (of isentropic flows) plays the part of a scalar potential in electromagnetism. The evolution of source terms of fluid Maxwell equations is determined by solving the equations of motion and continuity. The equation of sound waves can be derived from this formulation, where time evolution of the sound source is determined by the equation of motion. The theory of vortex sound of aeroacoustics is included in this formulation. It is remarkable that the forces acting on a point mass moving in a velocity field of an inviscid fluid are analogous in their form to the electric force and Lorentz force in electromagnetism. The significance of the reformulation is interpreted by examples taken from fluid mechanics. This formulation can be extended to viscous fluids without difficulty. The Maxwell-type equations are unchanged by the viscosity effect, although the source terms have additional terms due to viscosities.

Degenerate nonlinear diffusion equations

CERN Document Server

Favini, Angelo

2012-01-01

The aim of these notes is to include in a uniform presentation style several topics related to the theory of degenerate nonlinear diffusion equations, treated in the mathematical framework of evolution equations with multivalued m-accretive operators in Hilbert spaces. The problems concern nonlinear parabolic equations involving two cases of degeneracy. More precisely, one case is due to the vanishing of the time derivative coefficient and the other is provided by the vanishing of the diffusion coefficient on subsets of positive measure of the domain. From the mathematical point of view the results presented in these notes can be considered as general results in the theory of degenerate nonlinear diffusion equations. However, this work does not seek to present an exhaustive study of degenerate diffusion equations, but rather to emphasize some rigorous and efficient techniques for approaching various problems involving degenerate nonlinear diffusion equations, such as well-posedness, periodic solutions, asympt...

Computational partial differential equations using Matlab

CERN Document Server

Li, Jichun

2008-01-01

Brief Overview of Partial Differential Equations The parabolic equations The wave equations The elliptic equations Differential equations in broader areasA quick review of numerical methods for PDEsFinite Difference Methods for Parabolic Equations Introduction Theoretical issues: stability, consistence, and convergence 1-D parabolic equations2-D and 3-D parabolic equationsNumerical examples with MATLAB codesFinite Difference Methods for Hyperbolic Equations IntroductionSome basic difference schemes Dissipation and dispersion errors Extensions to conservation lawsThe second-order hyperbolic PDE

Integrable systems of partial differential equations determined by structure equations and Lax pair

International Nuclear Information System (INIS)

Bracken, Paul

2010-01-01

It is shown how a system of evolution equations can be developed both from the structure equations of a submanifold embedded in three-space as well as from a matrix SO(6) Lax pair. The two systems obtained this way correspond exactly when a constraint equation is selected and imposed on the system of equations. This allows for the possibility of selecting the coefficients in the second fundamental form in a general way.

Drift-Diffusion Equation

Directory of Open Access Journals (Sweden)

K. Banoo

1998-01-01

equation in the discrete momentum space. This is shown to be similar to the conventional drift-diffusion equation except that it is a more rigorous solution to the Boltzmann equation because the current and carrier densities are resolved into M×1 vectors, where M is the number of modes in the discrete momentum space. The mobility and diffusion coefficient become M×M matrices which connect the M momentum space modes. This approach is demonstrated by simulating electron transport in bulk silicon.

Symmetries of the Euler compressible flow equations for general equation of state

Energy Technology Data Exchange (ETDEWEB)

Boyd, Zachary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ramsey, Scott D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Baty, Roy S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2015-10-15

The Euler compressible flow equations exhibit different Lie symmetries depending on the equation of state (EOS) of the medium in which the flow occurs. This means that, in general, different types of similarity solution will be available in different flow media. We present a comprehensive classification of all EOS’s to which the Euler equations apply, based on the Lie symmetries admitted by the corresponding flow equations, restricting to the case of 1-D planar, cylindrical, or spherical geometry. The results are conveniently summarized in tables. This analysis also clarifies past work by Axford and Ovsiannikov on symmetry classification.

Alternatives to the Dirac equation

International Nuclear Information System (INIS)

Girvin, S.M.; Brownstein, K.R.

1975-01-01

Recent work by Biedenharn, Han, and van Dam (BHvD) has questioned the uniqueness of the Dirac equation. BHvD have obtained a two-component equation as an alternate to the Dirac equation. Although they later show their alternative to be unitarily equivalent to the Dirac equation, certain physical differences were claimed. BHvD attribute the existence of this alternate equation to the fact that their factorizing matrices were position-dependent. To investigate this, we factor the Klein-Gordon equation in spherical coordinates allowing the factorizing matrices to depend arbitrarily upon theta and phi. It is shown that despite this additional freedom, and without involving any relativistic covariance, the conventional four-component Dirac equation is the only possibility

Nonlinear differential equations

Energy Technology Data Exchange (ETDEWEB)

Dresner, L.

1988-01-01

This report is the text of a graduate course on nonlinear differential equations given by the author at the University of Wisconsin-Madison during the summer of 1987. The topics covered are: direction fields of first-order differential equations; the Lie (group) theory of ordinary differential equations; similarity solutions of second-order partial differential equations; maximum principles and differential inequalities; monotone operators and iteration; complementary variational principles; and stability of numerical methods. The report should be of interest to graduate students, faculty, and practicing scientists and engineers. No prior knowledge is required beyond a good working knowledge of the calculus. The emphasis is on practical results. Most of the illustrative examples are taken from the fields of nonlinear diffusion, heat and mass transfer, applied superconductivity, and helium cryogenics.

Nonlinear differential equations

International Nuclear Information System (INIS)

Dresner, L.

1988-01-01

This report is the text of a graduate course on nonlinear differential equations given by the author at the University of Wisconsin-Madison during the summer of 1987. The topics covered are: direction fields of first-order differential equations; the Lie (group) theory of ordinary differential equations; similarity solutions of second-order partial differential equations; maximum principles and differential inequalities; monotone operators and iteration; complementary variational principles; and stability of numerical methods. The report should be of interest to graduate students, faculty, and practicing scientists and engineers. No prior knowledge is required beyond a good working knowledge of the calculus. The emphasis is on practical results. Most of the illustrative examples are taken from the fields of nonlinear diffusion, heat and mass transfer, applied superconductivity, and helium cryogenics

Semilinear Schrödinger equations

CERN Document Server

Cazenave, Thierry

2003-01-01

The nonlinear Schrödinger equation has received a great deal of attention from mathematicians, in particular because of its applications to nonlinear optics. It is also a good model dispersive equation, since it is often technically simpler than other dispersive equations, such as the wave or Korteweg-de Vries equation. Particularly useful tools in studying the nonlinear Schrödinger equation are energy and Strichartz's estimates. This book presents various mathematical aspects of the nonlinear Schrödinger equation. It examines both problems of local nature (local existence of solutions, unique

Symplectic approach to calculation of magnetic field line trajectories in physical space with realistic magnetic geometry in divertor tokamaks

Science.gov (United States)

Punjabi, Alkesh; Ali, Halima

2008-12-01

A new approach to integration of magnetic field lines in divertor tokamaks is proposed. In this approach, an analytic equilibrium generating function (EGF) is constructed in natural canonical coordinates (ψ,θ) from experimental data from a Grad-Shafranov equilibrium solver for a tokamak. ψ is the toroidal magnetic flux and θ is the poloidal angle. Natural canonical coordinates (ψ,θ,φ) can be transformed to physical position (R,Z,φ) using a canonical transformation. (R,Z,φ) are cylindrical coordinates. Another canonical transformation is used to construct a symplectic map for integration of magnetic field lines. Trajectories of field lines calculated from this symplectic map in natural canonical coordinates can be transformed to trajectories in real physical space. Unlike in magnetic coordinates [O. Kerwin, A. Punjabi, and H. Ali, Phys. Plasmas 15, 072504 (2008)], the symplectic map in natural canonical coordinates can integrate trajectories across the separatrix surface, and at the same time, give trajectories in physical space. Unlike symplectic maps in physical coordinates (x,y) or (R,Z), the continuous analog of a symplectic map in natural canonical coordinates does not distort trajectories in toroidal planes intervening the discrete map. This approach is applied to the DIII-D tokamak [J. L. Luxon and L. E. Davis, Fusion Technol. 8, 441 (1985)]. The EGF for the DIII-D gives quite an accurate representation of equilibrium magnetic surfaces close to the separatrix surface. This new approach is applied to demonstrate the sensitivity of stochastic broadening using a set of perturbations that generically approximate the size of the field errors and statistical topological noise expected in a poloidally diverted tokamak. Plans for future application of this approach are discussed.

Symplectic approach to calculation of magnetic field line trajectories in physical space with realistic magnetic geometry in divertor tokamaks

International Nuclear Information System (INIS)

Punjabi, Alkesh; Ali, Halima

2008-01-01

A new approach to integration of magnetic field lines in divertor tokamaks is proposed. In this approach, an analytic equilibrium generating function (EGF) is constructed in natural canonical coordinates (ψ,θ) from experimental data from a Grad-Shafranov equilibrium solver for a tokamak. ψ is the toroidal magnetic flux and θ is the poloidal angle. Natural canonical coordinates (ψ,θ,φ) can be transformed to physical position (R,Z,φ) using a canonical transformation. (R,Z,φ) are cylindrical coordinates. Another canonical transformation is used to construct a symplectic map for integration of magnetic field lines. Trajectories of field lines calculated from this symplectic map in natural canonical coordinates can be transformed to trajectories in real physical space. Unlike in magnetic coordinates [O. Kerwin, A. Punjabi, and H. Ali, Phys. Plasmas 15, 072504 (2008)], the symplectic map in natural canonical coordinates can integrate trajectories across the separatrix surface, and at the same time, give trajectories in physical space. Unlike symplectic maps in physical coordinates (x,y) or (R,Z), the continuous analog of a symplectic map in natural canonical coordinates does not distort trajectories in toroidal planes intervening the discrete map. This approach is applied to the DIII-D tokamak [J. L. Luxon and L. E. Davis, Fusion Technol. 8, 441 (1985)]. The EGF for the DIII-D gives quite an accurate representation of equilibrium magnetic surfaces close to the separatrix surface. This new approach is applied to demonstrate the sensitivity of stochastic broadening using a set of perturbations that generically approximate the size of the field errors and statistical topological noise expected in a poloidally diverted tokamak. Plans for future application of this approach are discussed.

Comparison of Magnetic Properties in a Magnetic Cloud and Its Solar Source on 2013 April 11-14

Science.gov (United States)

Vemareddy, P.; Möstl, C.; Amerstorfer, T.; Mishra, W.; Farrugia, C.; Leitner, M.

2016-09-01

In the context of the Sun-Earth connection of coronal mass ejections and magnetic flux ropes (MFRs), we studied the solar active region (AR) and the magnetic properties of magnetic cloud (MC) event during 2013 April 14-15. We use in situ observations from the Advanced Composition Explorer and source AR measurements from the Solar Dynamics Observatory. The MCs magnetic structure is reconstructed from the Grad-Shafranov method, which reveals a northern component of the axial field with left handed helicity. The MC invariant axis is highly inclined to the ecliptic plane pointing northward and is rotated by 117° with respect to the source region PIL. The net axial flux and current in the MC are comparatively higher than from the source region. Linear force-free alpha distribution (10-7-10-6 m-1) at the sigmoid leg matches the range of twist number in the MC of 1-2 au MFR. The MFR is nonlinear force-free with decreasing twist from the axis (9 turns/au) toward the edge. Therefore, a Gold-Hoyle (GH) configuration, assuming a constant twist, is more consistent with the MC structure than the Lundquist configuration of increasing twist from the axis to boundary. As an indication of that, the GH configuration yields a better fitting to the global trend of in situ magnetic field components, in terms of rms, than the Lundquist model. These cylindrical configurations improved the MC fitting results when the effect of self-similar expansion of MFR was considered. For such twisting behavior, this study suggests an alternative fitting procedure to better characterize the MC magnetic structure and its source region links.

Performance evaluation of the Bio-Rad Laboratories GS HIV Combo Ag/Ab EIA, a 4th generation HIV assay for the simultaneous detection of HIV p24 antigen and antibodies to HIV-1 (groups M and O) and HIV-2 in human serum or plasma.

Science.gov (United States)

Bentsen, Christopher; McLaughlin, Lisa; Mitchell, Elizabeth; Ferrera, Carol; Liska, Sally; Myers, Robert; Peel, Sheila; Swenson, Paul; Gadelle, Stephane; Shriver, M Kathleen

2011-12-01

A multi-center study was conducted to evaluate the Bio-Rad GS HIV Combo Ag/Ab EIA, a 4th generation HIV-1/HIV-2 assay for the simultaneous detection of HIV p24 antigen and antibodies to HIV-1 (groups M and O) and HIV-2 in human serum or plasma in adult and pediatric populations. The objectives of the study were to assess assay performance for the detection of acute HIV infections; sensitivity in known HIV positive samples; percent agreement with HIV status; specificity in low and high risk individuals of unknown HIV status; and to compare assay performance to a 3rd generation HIV assay. The evaluation included testing 9150 samples at four U.S. clinical trial sites, using three kit lots. Unlinked samples were from routine testing, repositories or purchased from vendors. GS HIV Combo Ag/Ab EIA detection in samples from individuals in two separate populations with acute HIV infection was 95.2% (20/21) and 86.4% (38/44). Sensitivity was 100% (1603/1603) in known antibody positive [HIV-1 Groups M and O, and HIV-2] samples. HIV p24 antigen detection was 100% (53/53) in HIV-1 culture supernatants. HIV-1 seroconversion panel detection improved by a range of 0-20 days compared to a 3rd generation HIV test. Specificity was 99.9% (5989/5996) in low risk, 99.9% (959/960) in high risk and 100% (100/100) in pediatric populations. The GS HIV Combo Ag/Ab EIA significantly reduced the diagnostic window when compared to the 3rd generation screening assay, enabling earlier diagnosis of HIV infection. The performance parameters of the Bio-Rad GS HIV Combo Ag/Ab EIA are well suited for use in HIV diagnostic settings. Copyright © 2011 Elsevier B.V. All rights reserved.

Quantum linear Boltzmann equation

International Nuclear Information System (INIS)

Vacchini, Bassano; Hornberger, Klaus

2009-01-01

We review the quantum version of the linear Boltzmann equation, which describes in a non-perturbative fashion, by means of scattering theory, how the quantum motion of a single test particle is affected by collisions with an ideal background gas. A heuristic derivation of this Lindblad master equation is presented, based on the requirement of translation-covariance and on the relation to the classical linear Boltzmann equation. After analyzing its general symmetry properties and the associated relaxation dynamics, we discuss a quantum Monte Carlo method for its numerical solution. We then review important limiting forms of the quantum linear Boltzmann equation, such as the case of quantum Brownian motion and pure collisional decoherence, as well as the application to matter wave optics. Finally, we point to the incorporation of quantum degeneracies and self-interactions in the gas by relating the equation to the dynamic structure factor of the ambient medium, and we provide an extension of the equation to include internal degrees of freedom.

Exact Solutions to Nonlinear Schroedinger Equation and Higher-Order Nonlinear Schroedinger Equation

International Nuclear Information System (INIS)

Ren Ji; Ruan Hangyu

2008-01-01

We study solutions of the nonlinear Schroedinger equation (NLSE) and higher-order nonlinear Schroedinger equation (HONLSE) with variable coefficients. By considering all the higher-order effect of HONLSE as a new dependent variable, the NLSE and HONLSE can be changed into one equation. Using the generalized Lie group reduction method (GLGRM), the abundant solutions of NLSE and HONLSE are obtained

Verification of gyrokinetic microstability codes with an LHD configuration

Energy Technology Data Exchange (ETDEWEB)

Mikkelsen, D. R. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Nunami, M. [National Inst. for Fusion Science (Japan); Watanabe, T. -H. [Nagoya Univ. (Japan); Sugama, H. [National Inst. for Fusion Science (Japan); Tanaka, K. [National Inst. for Fusion Science (Japan)

2014-11-01

We extend previous benchmarks of the GS2 and GKV-X codes to verify their algorithms for solving the gyrokinetic Vlasov-Poisson equations for plasma microturbulence. Code benchmarks are the most complete way of verifying the correctness of implementations for the solution of mathematical models for complex physical processes such as those studied here. The linear stability calculations reported here are based on the plasma conditions of an ion-ITB plasma in the LHD configuration. The plasma parameters and the magnetic geometry differ from previous benchmarks involving these codes. We find excellent agreement between the independently written pre-processors that calculate the geometrical coefficients used in the gyrokinetic equations. Grid convergence tests are used to establish the resolution and domain size needed to obtain converged linear stability results. The agreement of the frequencies, growth rates and eigenfunctions in the benchmarks reported here provides additional verification that the algorithms used by the GS2 and GKV-X codes are correctly finding the linear eigenvalues and eigenfunctions of the gyrokinetic Vlasov-Poisson equations.

Nonlinear diffusion equations

CERN Document Server

Wu Zhuo Qun; Li Hui Lai; Zhao Jun Ning

2001-01-01

Nonlinear diffusion equations, an important class of parabolic equations, come from a variety of diffusion phenomena which appear widely in nature. They are suggested as mathematical models of physical problems in many fields, such as filtration, phase transition, biochemistry and dynamics of biological groups. In many cases, the equations possess degeneracy or singularity. The appearance of degeneracy or singularity makes the study more involved and challenging. Many new ideas and methods have been developed to overcome the special difficulties caused by the degeneracy and singularity, which

On the F-equation

International Nuclear Information System (INIS)

Kalinowski, M.W.; Szymanowski, L.

1982-03-01

A generalization of the Truesdell F-equations is proposed and some solutions to them - generalized Fox F-functions - are found. It is also shown that a non-linear difference-differential equation, which does not belong to the Truesdell class, nevertheless may be transformed into the standard F-equation. (author)

How to obtain the covariant form of Maxwell's equations from the continuity equation

Energy Technology Data Exchange (ETDEWEB)

Heras, Jose A [Departamento de Ciencias Basicas, Universidad Autonoma Metropolitana, Unidad Azcapotzalco, Av. San Pablo No. 180, Col. Reynosa, 02200, Mexico D. F. (Mexico); Departamento de Fisica y Matematicas, Universidad Iberoamericana, Prolongacion Paseo de la Reforma 880, Mexico D. F. 01210 (Mexico)

2009-07-15

The covariant Maxwell equations are derived from the continuity equation for the electric charge. This result provides an axiomatic approach to Maxwell's equations in which charge conservation is emphasized as the fundamental axiom underlying these equations.

Linear integral equations and soliton systems

International Nuclear Information System (INIS)

Quispel, G.R.W.

1983-01-01

A study is presented of classical integrable dynamical systems in one temporal and one spatial dimension. The direct linearizations are given of several nonlinear partial differential equations, for example the Korteweg-de Vries equation, the modified Korteweg-de Vries equation, the sine-Gordon equation, the nonlinear Schroedinger equation, and the equation of motion for the isotropic Heisenberg spin chain; the author also discusses several relations between these equations. The Baecklund transformations of these partial differential equations are treated on the basis of a singular transformation of the measure (or equivalently of the plane-wave factor) occurring in the corresponding linear integral equations, and the Baecklund transformations are used to derive the direct linearization of a chain of so-called modified partial differential equations. Finally it is shown that the singular linear integral equations lead in a natural way to the direct linearizations of various nonlinear difference-difference equations. (Auth.)

Lectures on partial differential equations

CERN Document Server

Petrovsky, I G

1992-01-01

Graduate-level exposition by noted Russian mathematician offers rigorous, transparent, highly readable coverage of classification of equations, hyperbolic equations, elliptic equations and parabolic equations. Wealth of commentary and insight invaluable for deepening understanding of problems considered in text. Translated from the Russian by A. Shenitzer.

Reduction operators of Burgers equation.

Science.gov (United States)

Pocheketa, Oleksandr A; Popovych, Roman O

2013-02-01

The solution of the problem on reduction operators and nonclassical reductions of the Burgers equation is systematically treated and completed. A new proof of the theorem on the special "no-go" case of regular reduction operators is presented, and the representation of the coefficients of operators in terms of solutions of the initial equation is constructed for this case. All possible nonclassical reductions of the Burgers equation to single ordinary differential equations are exhaustively described. Any Lie reduction of the Burgers equation proves to be equivalent via the Hopf-Cole transformation to a parameterized family of Lie reductions of the linear heat equation.

The magnetic field experiment onboard Equator-S and its scientific possibilities

Directory of Open Access Journals (Sweden)

K.-H. Fornacon

1999-12-01

Full Text Available The special feature of the ringcore fluxgate magnetometer on Equator-S is the high time and field resolution. The scientific aim of the experiment is the investigation of waves in the 10–100 picotesla range with a time resolution up to 64 Hz. The instrument characteristics and the influence of the spacecraft on the magnetic field measurement will be discussed. The work shows that the applied pre- and inflight calibration techniques are sufficient to suppress spacecraft interferences. The offset in spin axis direction was determined for the first time with an independent field measurement by the Equator-S Electron Drift Instrument. The data presented gives an impression of the accuracy of the measurement.Key words. Magnetospheric physics (instruments and techniques · Space plasma physics (instruments and techniques

The magnetic field experiment onboard Equator-S and its scientific possibilities

Directory of Open Access Journals (Sweden)

K.-H. Fornacon

Full Text Available The special feature of the ringcore fluxgate magnetometer on Equator-S is the high time and field resolution. The scientific aim of the experiment is the investigation of waves in the 10–100 picotesla range with a time resolution up to 64 Hz. The instrument characteristics and the influence of the spacecraft on the magnetic field measurement will be discussed. The work shows that the applied pre- and inflight calibration techniques are sufficient to suppress spacecraft interferences. The offset in spin axis direction was determined for the first time with an independent field measurement by the Equator-S Electron Drift Instrument. The data presented gives an impression of the accuracy of the measurement.

Key words. Magnetospheric physics (instruments and techniques · Space plasma physics (instruments and techniques