FIBRIN GLUE DAN APLIKASINYA

Directory of Open Access Journals (Sweden)

Agi Harliani S

2015-08-01

Full Text Available Fibrin Tissue Adhesive (FTA, Fibrin Sealant (FS or Fibrin Glue (FG are names given to a group of product that lead to the formation of fibrin clot at the site of application. Fibrin Glue represents a new revolution for local haemostatic, which produced by based on the understanding about blood coagulation process. The mechanism of FG mimics the last stage of blood coagulation process. Haemophilia, is a congenital inherited bleeding disorder, characterized by repeated bleeding episodes. The basic pathology is deficiency of factor VIII (hemophilia A or factor IX (hemophilia B. At bleeding episodes, hemophilia patients need replacement therapy. Hemophilia patients need transfusion of cryoprecipitate, Fresh Frozen Plasma (FFP or factor concentrate as replacement therapy. Oral surgery, dental extraction, circumcision, and orthopedic operations are the most important indications for fibrin glue in hemophilia care. As haemostatic local, FG minimizes bleeding, reducing the need of transfusion or factor concentrate, reducing the complication of transfusion, hospitalization and cost.

Safety of Synthetic Glue Used for Laparoscopic Prolapse Treatment.

Science.gov (United States)

Sarasa Castelló, Núria; Toth, Alexandra; Canis, Michel; Botchorishvilli, Revaz

2017-12-29

We detected mesh erosion and serious postoperative complications in 3 women after performing laparoscopic promontofixation (LPF) using glue for mesh fixation. Glue, largely used in hernia surgery repair, is proposed by some gynecologic surgeons because it saves time and is easier to use than traditional sutures. We report 3 cases of postoperative complications after LPF in which glue had been used and provide research in the published literature about the use of glue in LPF. A research of glue use in gynecology mesh fixation was performed through PubMed on October 2016. The search was done using the Medical Subject Heading terms "POP" & "Laparoscopy" & "surgical Mesh" and the word either "glue" or "adhesive. Only 2 articles were found: Willecocq et al [1] and Estrade et al [2]. Neither study focused on postoperative complications. In this publication, we accurately edited video surgeries with an instructive purpose. University Hospital of Clermont-Ferrand, France. Patient A, a 65-year-old woman, complained of pelvic pain and vaginal discharge 1 month after LPF (polypropylene mesh and glue had been used). Wall mesh exposure and purulent discharge were noted. She received antibiotics and underwent mesh ablation surgery; debris of the glue was easily identified. Patient B, a 65-year-old lady with previous hysterectomy consulted for a bulging feeling in her vagina (classification: cystocele +2; rectocele +3 stage). An LPF was performed using polypropylene soft nonabsorbable mesh and glue. One month later, an apical defect of vaginal epithelialization was detected; she received long estrogenic local treatment but had to undergo surgery when presenting malodorous discharge and mesh exposure. The exposed mesh was removed, and pieces of glue were identified, having avoided mesh attachment. Patient C had a previous abdominal hysterectomy and promontofixation using a polyester mesh with glue. She consulted to us for vaginal mesh erosion covered with purulent discharge 3

Generalized Likelihood Uncertainty Estimation (GLUE) Using Multi-Optimization Algorithm as Sampling Method

Science.gov (United States)

Wang, Z.

2015-12-01

For decades, distributed and lumped hydrological models have furthered our understanding of hydrological system. The development of hydrological simulation in large scale and high precision elaborated the spatial descriptions and hydrological behaviors. Meanwhile, the new trend is also followed by the increment of model complexity and number of parameters, which brings new challenges of uncertainty quantification. Generalized Likelihood Uncertainty Estimation (GLUE) has been widely used in uncertainty analysis for hydrological models referring to Monte Carlo method coupled with Bayesian estimation. However, the stochastic sampling method of prior parameters adopted by GLUE appears inefficient, especially in high dimensional parameter space. The heuristic optimization algorithms utilizing iterative evolution show better convergence speed and optimality-searching performance. In light of the features of heuristic optimization algorithms, this study adopted genetic algorithm, differential evolution, shuffled complex evolving algorithm to search the parameter space and obtain the parameter sets of large likelihoods. Based on the multi-algorithm sampling, hydrological model uncertainty analysis is conducted by the typical GLUE framework. To demonstrate the superiority of the new method, two hydrological models of different complexity are examined. The results shows the adaptive method tends to be efficient in sampling and effective in uncertainty analysis, providing an alternative path for uncertainty quantilization.

Three-dimensional glue detection and evaluation based on linear structured light

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Xiao, Zhitao; Yang, Ruipeng; Geng, Lei; Liu, Yanbei

2018-01-01

During the online glue detection of body in white (BIW), the purpose of traditional glue detection based on machine vision is the localization and segmentation of glue, which is dissatisfactory for estimating the uniformity of glue with complex shape. A three-dimensional glue detection method based on the linear structured light and the movement parameters of robot is proposed. Firstly, the linear structured light and epipolar constraint algorithm are used for sign matching of binocular vision. Then, hand-eye relationship between robot and binocular camera is utilized to unified coordinate system. Finally, a structured light stripe extraction method is proposed to extract the sub-pixel coordinates of the light strip center. Experiments results demonstrate that the propose method can estimate the shape of glue accurately. For three kinds of glue with complex shape and uneven illumination, our method can detect the positions of blemishes. The absolute error of measurement is less than 1.04mm and the relative error is less than 10% respectively, which is suitable for online glue detection in BIW.

Comparison of two fibrin glues in anastomoses and skin closure.

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Park, W; Kim, W H; Lee, C H; Kim, D Y; Choi, J H; Huh, J W; Sung, H M; Kim, I S; Kweon, O K

2002-09-01

To control intra-operative haemorrhage, fibrin glues are preferred by many surgeons because of their biological advantages and convenience of application. Manufacturers have developed a few kinds of fibrin glues with a little difference in their composition. This study was to compare the effectiveness of two commercially available fibrin glues; Greenplast (Green Cross P. D. Company, Yongin, Korea) and Tisseel (Baxter-Immuno AG, Vienna, Austria). They were applied experimentally to several kinds of surgery in dogs - renal vessel anastomosis, partial splenectomy, intestinal anastomosis and incision skin wound - and evaluated for their haemostatic and adhesive effects. When the two glues were applied in renal vessel anastomosis, the amount of haemorrhage in artery and vein decreased significantly. They also decreased the haemorrhage in partial splenectomy. At 10 min after application of the glues to an incision skin wound, the tensile strengths developed were significantly higher than that of control. The present study indicates that two-component fibrin glues have a haemostatic effect as a mechanical barrier in renal vessel anastomosis and an adhesive effect in the early stage of incision skin wound closure, and the two glues have similar effects with no complications.

Caged Molecular Glues as Photoactivatable Tags for Nuclear Translocation of Guests in Living Cells.

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Arisaka, Akio; Mogaki, Rina; Okuro, Kou; Aida, Takuzo

2018-02-21

We developed dendritic caged molecular glues ( Caged Glue-R) as tags for nucleus-targeted drug delivery, whose multiple guanidinium ion (Gu + ) pendants are protected by an anionic photocleavable unit (butyrate-substituted nitroveratryloxycarbonyl; BA NVOC). Negatively charged Caged Glue-R hardly binds to anionic biomolecules because of their electrostatic repulsion. However, upon exposure of Caged Glue-R to UV light or near-infrared (NIR) light, the BA NVOC groups of Caged Glue-R are rapidly detached to yield an uncaged molecular glue ( Uncaged Glue-R) that carries multiple Gu + pendants. Because Gu + forms a salt bridge with PO 4 - , Uncaged Glue-R tightly adheres to anionic biomolecules such as DNA and phospholipids in cell membranes by a multivalent salt-bridge formation. When tagged with Caged Glue-R, guests can be taken up into living cells via endocytosis and hide in endosomes. However, when the Caged Glue-R tag is photochemically uncaged to form Uncaged Glue-R, the guests escape from the endosome and migrate into the cytoplasm followed by the cell nucleus. We demonstrated that quantum dots (QDs) tagged with Caged Glue-R can be delivered efficiently to cell nuclei eventually by irradiation with light.

Compounds from silicones alter enzyme activity in curing barnacle glue and model enzymes.

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Rittschof, Daniel; Orihuela, Beatriz; Harder, Tilmann; Stafslien, Shane; Chisholm, Bret; Dickinson, Gary H

2011-02-17

Attachment strength of fouling organisms on silicone coatings is low. We hypothesized that low attachment strength on silicones is, in part, due to the interaction of surface available components with natural glues. Components could alter curing of glues through bulk changes or specifically through altered enzyme activity. GC-MS analysis of silicone coatings showed surface-available siloxanes when the coatings were gently rubbed with a cotton swab for 15 seconds or given a 30 second rinse with methanol. Mixtures of compounds were found on 2 commercial and 8 model silicone coatings. The hypothesis that silicone components alter glue curing enzymes was tested with curing barnacle glue and with commercial enzymes. In our model, barnacle glue curing involves trypsin-like serine protease(s), which activate enzymes and structural proteins, and a transglutaminase which cross-links glue proteins. Transglutaminase activity was significantly altered upon exposure of curing glue from individual barnacles to silicone eluates. Activity of purified trypsin and, to a greater extent, transglutaminase was significantly altered by relevant concentrations of silicone polymer constituents. Surface-associated silicone compounds can disrupt glue curing and alter enzyme properties. Altered curing of natural glues has potential in fouling management.

Research on preparation of phosphate-modified animal glue binder for foundry use

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Wang, Tian-Shu; Liu, Wei-Hua; Li, Ying-Min

2018-03-01

In this paper, three phosphates were used as modifiers to modify animal glue binder. The structural characteristics and thermal properties of animal glue binder treated with phosphates were studied by Fourier transform-infrared spectroscopy, gel permeation chromatography and derivative thermogravimetric analysis. The results showed that the modified animal glue binder had better sand tensile strength and lower viscosity than untreated animal glue binder. The best modification process was as follows: the optimal amount of sodium carbonate was 4 wt% to animal glue; the optimal weight ratio of the modifiers was sodium pyrophosphate : sodium tripolyphosphate : sodium hexametaphosphate : animal glue = 3 : 3 : 4 : 100, and the optimal reaction should be performed at 80°C for a reaction time of 120 min. A final tensile strength of approximately 3.20 MPa was achieved and the viscosity value was approximately 880 mPa s.

Double Coaxial Microcatheter Technique for Glue Embolization of Renal Arteriovenous Malformations

International Nuclear Information System (INIS)

Uchikawa, Yoko; Mori, Kensaku; Shiigai, Masanari; Konishi, Takahiro; Hoshiai, Sodai; Ishigro, Toshitaka; Hiyama, Takashi; Nakai, Yasunobu; Minami, Manabu

2015-01-01

PurposeTo demonstrate the technical benefit of the double coaxial microcatheter technique for embolization of renal arteriovenous malformations (AVMs) with n-butyl cyanoacrylate and iodized oil (glue).Materials and MethodsSix consecutive patients (1 man and 5 women; mean age 61 years; range 44–77 years) with renal AVMs were included. Five patients had hematuria, and one had a risk of heart failure due to a large intrarenal arteriovenous shunt. All patients underwent transarterial embolization using glue and the double coaxial microcatheter technique with outer 2.6F and inner 1.9F microcatheters. After glue injection, the inner microcatheter was retracted, while the outer microcatheter was retained. We assessed the complications and clinical outcomes of this technique.ResultsTechnical success was achieved in all patients. In 9 sessions, 34 feeding arteries were embolized with glue using the double coaxial microcatheter technique, 1 was embolized with glue using a single microcatheter, and 2 were embolized with coils. The double coaxial microcatheter technique was useful for selecting small tortuous feeding arteries, preventing glue reflux to the proximal arteries, and approaching multiple feeding arteries without complete retraction of the microcatheters. As a minor complication, glue migrated into the venous system in four patients without any sequelae. In all patients, favorable clinical outcomes, including hematuria cessation in five patients and improvement of the large intrarenal arteriovenous shunt in one patient, were obtained without deterioration of renal function.ConclusionGlue embolization with the double coaxial microcatheter technique was useful for treating renal AVMs with multiple tortuous feeding arteries

Double Coaxial Microcatheter Technique for Glue Embolization of Renal Arteriovenous Malformations

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Uchikawa, Yoko, E-mail: jauchikawa@gmail.com [University of Tsukuba Hospital, Department of Radiology (Japan); Mori, Kensaku, E-mail: moriken@md.tsukuba.ac.jp [University of Tsukuba, Department of Radiology, Faculty of Medicine (Japan); Shiigai, Masanari, E-mail: m-41gai@yahoo.co.jp [Tsukuba Medical Center Hospital, Department of Radiology (Japan); Konishi, Takahiro, E-mail: soratobukangaruu@gmail.com [University of Tsukuba Hospital, Department of Radiology (Japan); Hoshiai, Sodai, E-mail: hoshiai@sb4.so-net.ne.jp [Ibaraki Prefectural Central Hospital, Department of Radiology (Japan); Ishigro, Toshitaka, E-mail: suzutokei@gmail.com; Hiyama, Takashi, E-mail: med-tak@hotmail.com [University of Tsukuba Hospital, Department of Radiology (Japan); Nakai, Yasunobu, E-mail: nakaiya@tmch.or.jp [Tsukuba Medical Center Hospital, Department of Neurosurgery (Japan); Minami, Manabu, E-mail: mminami@md.tsukuba.ac.jp [University of Tsukuba, Department of Radiology, Faculty of Medicine (Japan)

2015-10-15

PurposeTo demonstrate the technical benefit of the double coaxial microcatheter technique for embolization of renal arteriovenous malformations (AVMs) with n-butyl cyanoacrylate and iodized oil (glue).Materials and MethodsSix consecutive patients (1 man and 5 women; mean age 61 years; range 44–77 years) with renal AVMs were included. Five patients had hematuria, and one had a risk of heart failure due to a large intrarenal arteriovenous shunt. All patients underwent transarterial embolization using glue and the double coaxial microcatheter technique with outer 2.6F and inner 1.9F microcatheters. After glue injection, the inner microcatheter was retracted, while the outer microcatheter was retained. We assessed the complications and clinical outcomes of this technique.ResultsTechnical success was achieved in all patients. In 9 sessions, 34 feeding arteries were embolized with glue using the double coaxial microcatheter technique, 1 was embolized with glue using a single microcatheter, and 2 were embolized with coils. The double coaxial microcatheter technique was useful for selecting small tortuous feeding arteries, preventing glue reflux to the proximal arteries, and approaching multiple feeding arteries without complete retraction of the microcatheters. As a minor complication, glue migrated into the venous system in four patients without any sequelae. In all patients, favorable clinical outcomes, including hematuria cessation in five patients and improvement of the large intrarenal arteriovenous shunt in one patient, were obtained without deterioration of renal function.ConclusionGlue embolization with the double coaxial microcatheter technique was useful for treating renal AVMs with multiple tortuous feeding arteries.

Fibrin glue as agent for sealing corneal and conjunctival wound leaks.

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Scalcione, C; Ortiz-Vaquerizas, D; Said, D G; Dua, H S

2018-02-01

PurposeTo describe a novel use of fibrin glue in managing leaking blebs and leaking wounds following trauma or surgery.MethodsInterventional case series.ResultsWe report eight patients, including three where intra-operative or immediate post-penetrating keratoplasty recalcitrant leaks from the graft-host junction and/or openings created by the needle pass, were noted. All three had thin recipient beds in the sector of leak. This was managed by intra-cameral injection of fibrin glue in the affected quadrant. This stopped the leak and allowed the defect to heal. One patient of Descemets-stripping-endothelial-keratoplasty had leak from the surgical wound, which was also sealed with fibrin glue. Two patients with leaking glaucoma-surgery-related blebs were treated with intra-bleb injection of fibrin glue to stop the leak. One patient with a penetrating corneal injury with a metal wire had a brisk leak upon removal of the wire. This was sealed with fibrin glue. Another patient of chemical burn with spontaneous leaks was managed by glue injection in the perforations. Transient rise of intraocular pressure in one patient with a leaking bleb was the only adverse event recorded.ConclusionThis novel adaptation of the application of fibrin glue can help to deal with persistent intra-operative, post-operative and traumatic aqueous and air leaks.

Biomechanical and histologic evaluation of two application forms of surgical glue for mesh fixation to the abdominal wall.

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Ortillés, Á; Pascual, G; Peña, E; Rodríguez, M; Pérez-Köhler, B; Mesa-Ciller, C; Calvo, B; Bellón, J M

2017-11-01

The use of an adhesive for mesh fixation in hernia repair reduces chronic pain and minimizes tissue damage in the patient. This study was designed to assess the adhesive properties of a medium-chain (n-butyl) cyanoacrylate glue applied as drops or as a spray in a biomechanical and histologic study. Both forms of glue application were compared to the use of simple-loose or continuous-running polypropylene sutures for mesh fixation. Eighteen adult New Zealand White rabbits were used. For mechanical tests in an ex vivo and in vivo study, patches of polypropylene mesh were fixed to an excised fragment of healthy abdominal tissue or used to repair a partial abdominal wall defect in the rabbit respectively. Depending on the fixation method used, four groups of 12 implants each or 10 implants each respectively for the ex vivo and in vivo studies were established: Glue-Drops, Glue-Spray, Suture-Simple and Suture-Continuous. Biomechanical resistance in the ex vivo implants was tested five minutes after mesh fixation. In vivo implants for biomechanical and histologic assessment were collected at 14 days postimplant. In the ex vivo study, the continuous suture implants showed the highest failure sample tension, while the implants fixed with glue showed lower failure sample tension values. However, the simple and continuous suture implants returned the highest stretch values. In the in vivo implants, failure sample tension values were similar among groups while the implants fixed with a continuous running suture had the higher stretch values, and the glue-fixed implants the lower stretch values. All meshes showed good tissue integration within the host tissue regardless of the fixation method used. Our histologic study revealed the generation of a denser, more mature repair tissue when the cyanoacrylate glue was applied as a spray rather than as drops. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effectiveness of Fibrin Glue in Adherence of Skin Graft.

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Reddy, Konda Sireesha; Chittoria, Ravi Kumar; Babu, Preethitha; Marimuthu, Senthil Kumaran; Kumar, Sudhanva Hemanth; Subbarayan, Elan Kumar; Chavan, Vinayak; Mohapatra, Devi Prasad; Sivakumar, Dinesh Kumar; Friji, M T

2017-01-01

Graft fixation is important for graft take. Fibrin glue has been proposed as an ideal material, because of its human origin and it provides firm adhesion in seconds or minutes. To evaluate the efficiency of fibrin glue, in increasing the take of skin graft. Assessment includes surgical time taken for graft fixation, haematoma/seroma formation, engraftment and wound closure by day 14. The study is an observational prospective study conducted in the Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, from January 2016 to June 2016. Sixteen patients who underwent split skin grafting were assessed during the study period. Fibrin glue was used on the recipient bed before grafting. Better haemostasis and graft adhesion, with a significant reduction of surgical time, were noted. The safety profile of fibrin glue was excellent as indicated by the lack of any related serious adverse experiences. These findings demonstrate that it is safe and effective for attachment of skin grafts, with outcomes at least as good as conventional methods.

Observations on dimensional changes of sized canvas based on glue temperature

DEFF Research Database (Denmark)

Krarup Andersen, Cecil

2008-01-01

The aim of this study was to explore dimensional changes caused by water on sized canvas. Samples of new linen canvas were mounted on a rig for biaxial tensioning, holding a constant stress of 100 N/m in both weave directions. The samples were then sized with respectively warm fluent glue (45 °C......) or a cold gel (20 °C), both consisting of a 5 percent sheepskin glue extracted from parchment clippings. The warm glue was absorbed into the canvas structure, whereas the cold gel mostly stayed as a discrete layer on the canvas. Twice the amount of glue was therefore needed for the warm sizing. When...... of size layers during application is important to the dimensional reaction of a canvas painting that is exposed to water....

A framework for distributed mixed-language scientific applications

International Nuclear Information System (INIS)

Quarrie, D.R.

1996-01-01

The Object Management Group has defined an architecture (COBRA) for distributed object applications based on an Object Broker and Interface Definition Language. This project builds upon this architecture to establish a framework for the creation of mixed language scientific applications. A prototype compiler has been written that generates FORTRAN 90 or Eiffel subs and skeletons and the required C++ glue code from an input IDL file that specifies object interfaces. This generated code can be used directly for non-distributed mixed language applications or in conjunction with the C++ code generated from a commercial IDL compiler for distributed applications. A feasibility study is presently to see whether a fully integrated software development environment for distributed, mixed-language applications can be created by modifying the back-end code generator of a commercial CASE tool to emit IDL. (author)

Next generation of weather generators on web service framework

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Chinnachodteeranun, R.; Hung, N. D.; Honda, K.; Ines, A. V. M.

2016-12-01

Weather generator is a statistical model that synthesizes possible realization of long-term historical weather in future. It generates several tens to hundreds of realizations stochastically based on statistical analysis. Realization is essential information as a crop modeling's input for simulating crop growth and yield. Moreover, they can be contributed to analyzing uncertainty of weather to crop development stage and to decision support system on e.g. water management and fertilizer management. Performing crop modeling requires multidisciplinary skills which limit the usage of weather generator only in a research group who developed it as well as a barrier for newcomers. To improve the procedures of performing weather generators as well as the methodology to acquire the realization in a standard way, we implemented a framework for providing weather generators as web services, which support service interoperability. Legacy weather generator programs were wrapped in the web service framework. The service interfaces were implemented based on an international standard that was Sensor Observation Service (SOS) defined by Open Geospatial Consortium (OGC). Clients can request realizations generated by the model through SOS Web service. Hierarchical data preparation processes required for weather generator are also implemented as web services and seamlessly wired. Analysts and applications can invoke services over a network easily. The services facilitate the development of agricultural applications and also reduce the workload of analysts on iterative data preparation and handle legacy weather generator program. This architectural design and implementation can be a prototype for constructing further services on top of interoperable sensor network system. This framework opens an opportunity for other sectors such as application developers and scientists in other fields to utilize weather generators.

Effect of MHEC on evaporation and hydration characteristics of glue mortar

NARCIS (Netherlands)

Faiyas, A.P.A.; Erich, S.J.F.; Huinink, H.P.; Adan, O.C.G; Nijland, T.G.

2016-01-01

The influence of methylhydroxyethylcellulose (MHEC) on both moisture distribution and hydration characteristics of glue mortar using nuclear magnetic resonance imaging (NMR) is investigated. MHEC is added to glue mortar in order to control the drying rate by increasing the open time. Besides drying,

Fibrin glue as a protective tool for microanastomoses in limb reconstructive surgery

Directory of Open Access Journals (Sweden)

Langer, Stefan

2015-12-01

Full Text Available Aim: Fibrin glue becomes a more and more routinely used tool for stabilization of microanastomoses and nerve repair. This paper summarizes the technical properties and advantages of its use in a wide variety of microsurgical contexts, and includes an exemplary limb reconstructive case.Patients and methods: A total of 131 patients who had undergone elective and emergency microsurgery mainly of the limbs were retrospectively analyzed, as was the use of free flaps.Results: The use of fibrin glue allows for proper positioning of anastomoses and repaired nerves. No torsion of the pedicle could be seen. The flap survival rated >94%. The fibrin glue could stay in place in >99%. In the rare case of revision, the fibrin glue could easily be removed without damaging the region of the microanastomosis.Conclusion: Fibrin glue should not be used to repair insufficient, i.e., leaking anastomoses, but it does protect the site of anastomosis from tissue and fluid pressure. It prevents the pedickle from torsion and its use facilitates relocation of the microanastomoses in cases of revision surgery.

Characterisation of a new bioadhesive system based on polysaccharides with the potential to be used as bone glue.

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Hoffmann, Bettina; Volkmer, Elias; Kokott, Andreas; Augat, Peter; Ohnmacht, Michael; Sedlmayr, Nicole; Schieker, Matthias; Claes, Lutz; Mutschler, Wolf; Ziegler, Günter

2009-10-01

Although gluing bone is in theory a very attractive alternative to classical fracture treatment, this method is not yet clinically established due to the lack of an adhesive which would meet all the necessary requirements. We therefore developed a novel two-component bioadhesive system with the potential to be used as a bone adhesive based on biocompatible and degradable biopolymers (chitosan, oxidised dextran or starch). After mixing in water, the two components covalently cross-link by forming a Schiff's base. By the same mechanism, the glue binds to any other exposed amino group such as for example those exposed in fractured bone, even in the presence of water. Modified chitosan was synthesised from commercially available chitosan by deacetylation and was then reduced in molecular weight by heating in acid. The amount of free amino groups was analysed by IR. The molecular weight was determined by viscosimetry. Starch or dextran were oxidised with periodic acid to generate aldehyde groups, which were quantified by titration. l-Dopa was conjugated to oxidised dextran or starch in analogy to the gluing mechanism of mussels. Biomechanical studies revealed that the new glue is superior to fibrin glue, but has less adhesive strength than cyanoacrylates. In vitro cell testing demonstrated excellent biocompatibility, rendering this glue a potential candidate for clinical use.

Event based uncertainty assessment in urban drainage modelling, applying the GLUE methodology

DEFF Research Database (Denmark)

Thorndahl, Søren; Beven, K.J.; Jensen, Jacob Birk

2008-01-01

of combined sewer overflow. The GLUE methodology is used to test different conceptual setups in order to determine if one model setup gives a better goodness of fit conditional on the observations than the other. Moreover, different methodological investigations of GLUE are conducted in order to test......In the present paper an uncertainty analysis on an application of the commercial urban drainage model MOUSE is conducted. Applying the Generalized Likelihood Uncertainty Estimation (GLUE) methodology the model is conditioned on observation time series from two flow gauges as well as the occurrence...... if the uncertainty analysis is unambiguous. It is shown that the GLUE methodology is very applicable in uncertainty analysis of this application of an urban drainage model, although it was shown to be quite difficult of get good fits of the whole time series....

Krazy Glue® in the ear: A case report of child abuse.

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Sorichetti, Brendan D; Fandiño, Marcela; Kozak, Frederick K

2018-06-01

Krazy Glue ® or cyanoacrylate glue is an acrylic resin that polymerizes in less than a minute when in contact with moisture or water. We present a case of a one month old referred to our tertiary pediatric otolaryngology clinic from an outside emergency department with a history of application of cyanoacrylate glue in the external ear canals. This report presents the management of this case along with the medical and legal outcomes surrounding this case of child abuse. Copyright © 2018. Published by Elsevier B.V.

Information-provider scripts for GLUE2 and RAID configurations.

CERN Document Server

Kalimeris, Dimitrios

2014-01-01

This report will outline two projects that were done as part of a three months long summer internship at CERN. In the first project we dealt with Worldwide LHC Computing Grid (WLCG) and its information system. The information system currently conforms to a schema called GLUE and it is evolving towards a new version: GLUE2. The aim of the project was to develop and adapt the current information system of the WLCG, used by the Large Scale Storage Systems at CERN (CASTOR and EOS), to the new GLUE2 schema. During the second project we investigated different RAID configurations so that we can get performance boost from CERN's disk systems in the future. RAID 1 that is currently in use is not an option anymore because of limited performance and high cost. We tried to discover RAID configurations that will improve the performance and simultaneously decrease the cost.

Stroke from Delayed Embolization of Polymerized Glue Following Percutaneous Direct Injection of a Carotid Body Tumor

Energy Technology Data Exchange (ETDEWEB)

Krishnamoorthy, Thamburaj; Gupta, Arun Kumar; Rajan, Jayadevan E; Thomas, Bejoy [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, (India)

2007-06-15

Direct percutaneous embolization of hypervascular tumors results in more effective preoperative devascularization. Migration of glue is a well known complication of direct glue injection and it may lead to stroke or cranial nerve deficits. We report here on a case of carotid body tumor in a 52-year-old man; the tumor was mainly embolized by percutaneous injection of 50% glue and this was supported with balloon protection of the internal carotid artery. Thirteen hours later, he developed hemiparesis from delayed migration of glue. The possible mechanisms of this migration are discussed and preventive measures are suggested. Preoperative embolization of hypervascular tumors of the head and neck, including carotid body tumor, is often performed to decrease the amount of blood loss during surgery. Devascularization is mainly performed with particulate agents and by employing the transarterial route. More effective embolization may be achieved by performing percutaneous direct embolization of hypervascular tumors with liquid embolic agents. Even though there are few reports available on direct embolization, complications from glue migration have been reported, and this mainly happens during the procedure when the glue is in a liquid state. We report here on a case of delayed migration of polymerized glue (n-butyl-2-cyanoacrylate [NBCA]), many hours after the procedure, into the intracranial circulation and the final result was stroke. A 52-year-old male with right carotid body tumor underwent direct percutaneous glue (n-butylcyanoacrylate [NBCA]) embolization. Several hours later, he developed left hemiparesis from embolization of the polymerized glue cast. Migration of glue during percutaneous tumor embolization is presumed to occur only in the liquid state, which may lead to stroke or cranial nerve deficits. To the best of our knowledge, this is the first report of delayed glue embolization from a treated hypervascular tumor of the head and neck.

On the glue content in heavy quarkonia

International Nuclear Information System (INIS)

Gromes, D.

2003-01-01

Starting with two coupled Bethe-Salpeter equations for the quark-antiquark, and for the quark-glue-antiquark component of the quarkonium, we solve the bound state equations perturbatively. The resulting admixture of glue can be partially understood in a semiclassical way; one has, however, to take care of the different use of time ordered versus retarded Green functions. Subtle questions concerning the precise definition of the equal time wave function arise, because the wave function for the Coulomb gluon is discontinuous with respect to the relative time of the gluon. A striking feature is that a one loop non-abelian graph contributes to the same order as tree graphs, because the couplings of transverse gluons in the tree graphs are suppressed in the non-relativistic bound state, while the higher order loop graph can couple to quarks via non-suppressed Coulomb gluons. We also calculate the amplitude for quark and antiquark at zero distance in the quark-glue-antiquark component of the P-state. This quantity is of importance for annihilation decays of P-states. It shows a remarkable compensation between the tree graph and the non-abelian loop graph contribution. An extension of our results to include non-perturbative effects is possible. (orig.)

Glue versus suture for mesh fixation in inguinal hernia repair.

Science.gov (United States)

Chandrasekar, Shruthi; Jeyakumar, S; Ganapathy, Tharun

2018-03-22

Inguinal hernia is one of the most common surgical problem presenting to the surgical OPD. Surgery is the mainstay of treatment for inguinal hernia today. Surgery for inguinal hernia has undergone a great evolution over a period of several centuries. Lichenstein's tension free hernioplasty is the one of the first surgeries taught to a surgical resident. The main aim of surgeries in this era is to give the best possible results with the least possible pain, scar and time. This has given rise to so many modifications to the classical Lichenstein's procedure and also to laparoscopic hernioplasty. Pain after inguinal hernia surgery is found to be debilitating and altering the quality of life in several patients, which has been attributed to the traumatic fixation of the mesh with sutures. This has paved way to the development of various atraumatic methods of fixation, tissue glue is one such development. Hence this study, to compare traumatic and atraumatic methods of mesh fixation in inguinal hernia repair. The aim of this study was to compare suture fixation versus tissue glue fixation of the mesh in inguinal hernia repair. Primary objective was to compare the immediate and chronic post-operative pain. Secondary objective was to compare the time taken for the procedure by the two methods in use and also to compare the presence of any complications. and methodology: This study was done in the General Surgery department of XXX hospital, medical college and research centre, kattangulathur after Ethics committee clearance. It is a single blinded study. The study was done on 51 patients consenting for the study and meeting the inclusion criterias from the period of March 2016 to August 2017 out of which 26 were selected for glue mesh fixation and 25 for suture mesh fixation according to simple randomization. The suture group patients underwent classical Lichenstein's tension free hernioplasty and the glue group underwent Lichenstein's hernioplasty with glue where dots of

Glue detection based on teaching points constraint and tracking model of pixel convolution

Science.gov (United States)

Geng, Lei; Ma, Xiao; Xiao, Zhitao; Wang, Wen

2018-01-01

On-line glue detection based on machine version is significant for rust protection and strengthening in car production. Shadow stripes caused by reflect light and unevenness of inside front cover of car reduce the accuracy of glue detection. In this paper, we propose an effective algorithm to distinguish the edges of the glue and shadow stripes. Teaching points are utilized to calculate slope between the two adjacent points. Then a tracking model based on pixel convolution along motion direction is designed to segment several local rectangular regions using distance. The distance is the height of rectangular region. The pixel convolution along the motion direction is proposed to extract edges of gules in local rectangular region. A dataset with different illumination and complexity shape stripes are used to evaluate proposed method, which include 500 thousand images captured from the camera of glue gun machine. Experimental results demonstrate that the proposed method can detect the edges of glue accurately. The shadow stripes are distinguished and removed effectively. Our method achieves the 99.9% accuracies for the image dataset.

Glue therapy in hemoptysis: A new technique

Directory of Open Access Journals (Sweden)

Rakesh K Chawla

2012-01-01

Full Text Available Hemoptysis is defined as the spitting of blood derived from the lungs or bronchial tubes as a result of pulmonary or bronchial hemorrhage. There is a large chunk of patients with hemoptysis who do not respond to conservative treatment including use of cough suppressants, antibiotics, vitamin C, hemostatics, and anxiolytics. The advanced management of such a situation is bronchial artery embolization (BAE or open thoracic surgery, which is often not possible. We have attempted a cheap, effective, and safe alternative in the form of intrabronchial instillation of glue (n-butyl cyanoacrylate under vision with the help of a therapeutic video bronchoscope (OLYMPUS T-180. The glue is instilled through a polyethylene catheter placed through the working channel of the video bronchoscope.

Measurement of radiation damage on an epoxy-based optical glue

International Nuclear Information System (INIS)

Huang, H.C.; Peng, K.C.; Sahu, S.K.; Ueno, K.; Chang, Y.H.; Wang, C.H.; Hou, W.S.

1997-01-01

We measured the radiation damage on an optical glue called Eccobond-24, which is a candidate for CsI and BGO crystal calorimeters of the BELLE detector of the KEK B-factory. Absorption spectrophotometry in the range 300-800 nm was used to monitor the radiation damage. The maximum equivalent dose was 1.64 Mrad. The glue shows effects of damage, but is acceptable for the radiation level in the above-mentioned experiment. (orig.)

Glue from the Sea:Biomedical Adhesives Inspired by Algal Polymers

Institute of Scientific and Technical Information of China (English)

H.Bianco-Peled; R.Bitton; P.Potin

2007-01-01

1 Introduction Tissue repair following surgery or trauma has been dominated by sutures,staples and wiring.Although these techniques are well established and widely used,their application often involves pain,unaesthetic results,or bleeding. These limitations emphasize the need for adhesive products to be available to surgeons.2 ResultsA challenging aspect of developing new tissue adhesive is to create a material that can glue wet surfaces.The success of synthetic glues under such an environment is very ...

Second generation registry framework.

Science.gov (United States)

Bellgard, Matthew I; Render, Lee; Radochonski, Maciej; Hunter, Adam

2014-01-01

Information management systems are essential to capture data be it for public health and human disease, sustainable agriculture, or plant and animal biosecurity. In public health, the term patient registry is often used to describe information management systems that are used to record and track phenotypic data of patients. Appropriate design, implementation and deployment of patient registries enables rapid decision making and ongoing data mining ultimately leading to improved patient outcomes. A major bottleneck encountered is the static nature of these registries. That is, software developers are required to work with stakeholders to determine requirements, design the system, implement the required data fields and functionality for each patient registry. Additionally, software developer time is required for ongoing maintenance and customisation. It is desirable to deploy a sophisticated registry framework that can allow scientists and registry curators possessing standard computing skills to dynamically construct a complete patient registry from scratch and customise it for their specific needs with little or no need to engage a software developer at any stage. This paper introduces our second generation open source registry framework which builds on our previous rare disease registry framework (RDRF). This second generation RDRF is a new approach as it empowers registry administrators to construct one or more patient registries without software developer effort. New data elements for a diverse range of phenotypic and genotypic measurements can be defined at any time. Defined data elements can then be utilised in any of the created registries. Fine grained, multi-level user and workgroup access can be applied to each data element to ensure appropriate access and data privacy. We introduce the concept of derived data elements to assist the data element standards communities on how they might be best categorised. We introduce the second generation RDRF that

Use of Glubran 2 acrylic glue in interventional neuroradiology

International Nuclear Information System (INIS)

Raffi, L.; Simonetti, L.; Cenni, P.; Leonardi, M.

2007-01-01

Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease. We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel. There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization. The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use. (orig.)

Clustering for Generating Framework Top-Level Views

DEFF Research Database (Denmark)

Schäfer, Thorsten; Aracic, Ivica; Merz, Matthias

2007-01-01

To use a framework, developers need to understand its building blocks. In this paper, we present a clustering technique that employs usage data from framework instantiations as examples to produce an overview of a framework's main building blocks as seen from a user's perspective. The evaluation...... of the approach by two case studies shows that the automatically generated building blocks are similar to a manually defined overview created by framework experts, even in cases where only few framework instantiations are available....

Determination of fibrin glue with antibiotics on collagen production in colon anastomosis

Directory of Open Access Journals (Sweden)

Stanojković Zoran

2008-01-01

Full Text Available Background/Aim. Fibrin glue is used as a matrix for local application of antibiotics. The aim of this study was to determine whether application of fibrin glue in combination with antibiotics can strengthen collagen production, prevent dehiscence of colon anastomoses due to infection, and reduce frequency of mortality and morbidity comparing to the control group and the group with fibrin glue application. Methods. The adult male Wistar rats divided into three groups were used in the experiment. The group 1 was the control one (after partial colon resection, colonic anastomoses performed were not treated, while to the group 2 and the group 3 were applied fibrin glue and fibrin glue with antibiotics (clindamycin and ceftriaxon on the site of anastomoses, respectively. Quality of colonic anastomoses were estimated by means of determination of collagen (L-hydroxyproline amount in the collon wall with anastomoses and histological analysis of this colon segment using light and electronic microscope on the days 5, 7 and 13 postoperatively. Results. The highest morbidity rate was registered in the group 1 (30%, then in the group 2 (13.3% and the lowest one in the group 3 (3.33%; p < 0,05 vs group 1. Mortality rate was significantly higher in the group 1 than in the group 3 (20% and 0%, respectively; p < 0,05. In the postoperative course, the highest concentrations of collagen in the colon wall on the site of anastomoses, which was confirmed by both light and electronic microscopy, were found in the group 3. Conclusion. The application of fibrin glue with antibiotics on colon anastomoses reduces the number of dehiscence, provides good mechanical protection and shorten the time of anastomoses healing.

Sealing of Gastrointestinal Anastomoses with a Fibrin Glue-Coated Collagen Patch: A Safety Study

DEFF Research Database (Denmark)

Nordentoft, Tyge; Rømer, John; Sørensen, Michael

2007-01-01

gastrointestinal anastomoses with a collagen patch coated with fibrin glue. The study is a prospective, experimental animal study comparing sealed and unsealed gastrointestinal anastomoses. Laparotomy was performed in 11 pigs under general anesthesia. In each pig two anastomoses were performed on the small......Sealing of anastomoses has previously been tested with several methods, including sealing with liquid fibrin glue. Sealing with a collagen patch coated with fibrin glue components has never been systematically examined. The aim of the present study was to determine the safety of sealing...... intestine. One of the anastomoses was sealed with a collagen patch coated with fibrin glue components (TachoSil). The other anastomosis contained no sealing. The pigs were observed for 1 to 6 weeks. The observation period was followed by in vivo examination under general anesthesia and included observation...

Hearing loss in a glue sniffer.

Science.gov (United States)

Williams, D M

1988-10-01

A case is presented of a 27-year-old glue sniffing woman with sensorineural hearing loss, optic atrophy and global brain damage. This form of addiction has not received much attention as a cause of otologic catastrophes, and should be borne in mind where similar cases come to the otolaryngologist.

Informal uncertainty analysis (GLUE of continuous flow simulation in a hybrid sewer system with infiltration inflow – consistency of containment ratios in calibration and validation?

Directory of Open Access Journals (Sweden)

A. Breinholt

2013-10-01

Full Text Available Monitoring of flows in sewer systems is increasingly applied to calibrate urban drainage models used for long-term simulation. However, most often models are calibrated without considering the uncertainties. The generalized likelihood uncertainty estimation (GLUE methodology is here applied to assess parameter and flow simulation uncertainty using a simplified lumped sewer model that accounts for three separate flow contributions: wastewater, fast runoff from paved areas, and slow infiltrating water from permeable areas. Recently GLUE methodology has been critisised for generating prediction limits without statistical coherence and consistency and for the subjectivity in the choice of a threshold value to distinguish "behavioural" from "non-behavioural" parameter sets. In this paper we examine how well the GLUE methodology performs when the behavioural parameter sets deduced from a calibration period are applied to generate prediction bounds in validation periods. By retaining an increasing number of parameter sets we aim at obtaining consistency between the GLUE generated 90% prediction limits and the actual containment ratio (CR in calibration. Due to the large uncertainties related to spatio-temporal rain variability during heavy convective rain events, flow measurement errors, possible model deficiencies as well as epistemic uncertainties, it was not possible to obtain an overall CR of more than 80%. However, the GLUE generated prediction limits still proved rather consistent, since the overall CRs obtained in calibration corresponded well with the overall CRs obtained in validation periods for all proportions of retained parameter sets evaluated. When focusing on wet and dry weather periods separately, some inconsistencies were however found between calibration and validation and we address here some of the reasons why we should not expect the coverage of the prediction limits to be identical in calibration and validation periods in real

Photoclickable dendritic molecular glue: noncovalent-to-covalent photochemical transformation of protein hybrids.

Science.gov (United States)

Uchida, Noriyuki; Okuro, Kou; Niitani, Yamato; Ling, Xiao; Ariga, Takayuki; Tomishige, Michio; Aida, Takuzo

2013-03-27

A water-soluble dendron with a fluorescein isothiocyanate (FITC) fluorescent label and bearing nine pendant guanidinium ion (Gu(+))/benzophenone (BP) pairs at its periphery (Glue(BP)-FITC) serves as a "photoclickable molecular glue". By multivalent salt-bridge formation between Gu(+) ions and oxyanions, Glue(BP)-FITC temporarily adheres to a kinesin/microtubule hybrid. Upon subsequent exposure to UV light, this noncovalent binding is made permanent via a cross-linking reaction mediated by carbon radicals derived from the photoexcited BP units. This temporal-to-permanent transformation by light occurs quickly and efficiently in this preorganized state, allowing the movements of microtubules on a kinesin-coated glass plate to be photochemically controlled. A fundamental difference between such temporal and permanent bindings was visualized by the use of "optical tweezers".

Effect of BioGlue on the incidence of pancreatic fistula following pancreas resection.

Science.gov (United States)

Fisher, William E; Chai, Christy; Hodges, Sally E; Wu, Meng-Fen; Hilsenbeck, Susan G; Brunicardi, F Charles

2008-05-01

Despite numerous modifications of surgical technique, pancreatic fistula remains a serious problem and occurs in about 10% of patients following pancreas resection. BioGlue is a new sealant that creates a flexible mechanical seal within minutes independent of the body's clotting mechanism. Application of BioGlue sealant will reduce the incidence of pancreatic fistula following pancreas resection. A retrospective cohort study was performed with 64 patients undergoing pancreas resection. BioGlue sealant was applied to the pancreatic anastomosis (Whipple) or resection margin (distal pancreatectomy) in 32 cases. Factors that could affect the rate of postoperative pancreatic fistula were recorded. Pancreatic fistula was defined as greater than 50 ml of drain output with an amylase content greater than three times normal serum value after postoperative day 10. To improve the sensitivity of our study, we also examined pancreatic fistula with a strict definition of any drain output on or after postoperative day 3 with a high amylase content and graded the fistulas in terms of clinical severity. Grade A leaks were defined as subclinical. Grade B leaks required some response such as making the patient nil per os, parenteral nutrition, octreotide, antibiotics, or a prolonged hospital stay. Grade C leaks were defined as serious and life threatening. They were associated with hemorrhage, sepsis, resulted in deterioration of other organ systems, and mandated intensive care. Comparisons between the two groups were made using the chi-square test or Fisher's exact test for categorical variables and by the Wilcoxon rank-sum test for continuous variables. P values of 0.05 or less were deemed statistically significant. There were no differences between the patients who received BioGlue and the control cohort in terms of comorbid conditions, tumor location, texture of the pancreas, size of the pancreatic duct, or surgical technique. By the common definition, pancreatic fistula occurred

Optimization of performance parameters for large area silicon photomultipliers for use in the GlueX experiment

Science.gov (United States)

Janzen, Kathryn Louise

Largely because of their resistance to magnetic fields, silicon photomultipliers (SiPMs) are being considered as the readout for the GlueX Barrel Calorimeter, a key component of the GlueX detector located immediately inside a 2.2 T superconducting solenoid. SiPMs with active area 1 x 1 mm2 have been investigated for use in other experiments, but detectors with larger active areas are required for the GlueX BCAL. This puts the GlueX collaboration in the unique position of being pioneers in the use of this frontend detection revolution by driving the technology for larger area sensors. SensL, a photonics research and development company in Ireland, has been collaborating with the University of Regina GlueX group to develop prototype large area SiPMs comprising 16 - 3x3 mm2 cells assembled in a close-packed matrix. Performance parameters of individual SensL 1x1 mm2 and 3x3 mm2 SiPMs along with prototype SensL SiPM arrays are tested, including current versus voltage characteristics, photon detection efficiency, and gain uniformity, in an effort to determine the suitability of these detectors to the GlueX BCAL readout.

[Chemical hazards when working with solvent glues].

Science.gov (United States)

Domański, Wojciech; Makles, Zbigniew

2012-01-01

Solvent glues are used in a wide variety of industries, e.g., textile, footwear and rubber. The problem of workers' exposure to solvent vapors is rarely tackled within the area of occupational safety and health in small and medium-sized enterprises. In order to assess exposure to solvents, organic solvents emitted by glues were identified in the samples of workplace air. The concentration of acetone, benzene, cyclohexane, ethylbenzene, n-hexane, methylcyclohexane, butyl acetate and toluene were determined. The obtained results evidenced the presence of cyclohexane, ethylbenzene, ethylcyclohexane, heptane, n-hexane, o-xylene, methylcyclohexane, methylcyclopentane, butyl acetate and toluene in workplace air. The concentration of those compounds in workplace air was low, usually below 0.15 of MAC. At some workstations the presence of benzene was also observed. Occupational risk was assessed at workstations where gluing took place. It showed that the risk at those workstations was medium or low.

Sediment Curve Uncertainty Estimation Using GLUE and Bootstrap Methods

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aboalhasan fathabadi

2017-02-01

Full Text Available Introduction: In order to implement watershed practices to decrease soil erosion effects it needs to estimate output sediment of watershed. Sediment rating curve is used as the most conventional tool to estimate sediment. Regarding to sampling errors and short data, there are some uncertainties in estimating sediment using sediment curve. In this research, bootstrap and the Generalized Likelihood Uncertainty Estimation (GLUE resampling techniques were used to calculate suspended sediment loads by using sediment rating curves. Materials and Methods: The total drainage area of the Sefidrood watershed is about 560000 km2. In this study uncertainty in suspended sediment rating curves was estimated in four stations including Motorkhane, Miyane Tonel Shomare 7, Stor and Glinak constructed on Ayghdamosh, Ghrangho, GHezelOzan and Shahrod rivers, respectively. Data were randomly divided into a training data set (80 percent and a test set (20 percent by Latin hypercube random sampling.Different suspended sediment rating curves equations were fitted to log-transformed values of sediment concentration and discharge and the best fit models were selected based on the lowest root mean square error (RMSE and the highest correlation of coefficient (R2. In the GLUE methodology, different parameter sets were sampled randomly from priori probability distribution. For each station using sampled parameter sets and selected suspended sediment rating curves equation suspended sediment concentration values were estimated several times (100000 to 400000 times. With respect to likelihood function and certain subjective threshold, parameter sets were divided into behavioral and non-behavioral parameter sets. Finally using behavioral parameter sets the 95% confidence intervals for suspended sediment concentration due to parameter uncertainty were estimated. In bootstrap methodology observed suspended sediment and discharge vectors were resampled with replacement B (set to

The Effect of Seaweed Glue in the Separation of Copper–Molybdenum Sulphide Ore by Flotation

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Zhixiang Chen

2018-01-01

Full Text Available Flotation separation of chalcopyrite from molybdenite was studied using seaweed glue (SEG as a depressant. Flotation process and mechanism were examined by response surface methodology, flotation tests, adsorption tests, zeta potential measurements and fourier transform infrared (FT-IR spectra. Response surface methodology with a Box–Behnken design suggested the optimal reagent schedule: pH 4, depressant seaweed glue 197 mg/L, collector amyl xanthate 16 mg/L and frother (methyl isobutyl carbinol 20 mg/L, and selective separation of chalcopyrite and molybdenite was achieved by flotation. Comparison of SEG and traditional depressants indicated that the SEG could achieve a similar separation efficiency, and exhibited the advantages of environmental compatibility and economic adaptability. Co-adsorption of seaweed glue and amyl xanthate occurred on the surface of molybdenite, and is explained to happen through distinct mechanisms due to the heterogeneous nature of the surface. It is likely that seaweed glue depresses molybdenite by covering the dixanthogen resulting from adsorption of xanthate ions. It is shown that seaweed glue is as effective a depressant of Cu/Mo separation as cyanide.

Photocurable surgical tissue adhesive glues composed of photoreactive gelatin and poly(ethylene glycol) diacrylate.

Science.gov (United States)

Nakayama, Y; Matsuda, T

1999-01-01

This article presents a novel photochemically driven surgical tissue adhesive technology using photoreactive gelatins and a water-soluble difunctional macromer (poly(ethylene glycol) diacrylate: PEGDA).The gelatins were partially derivatized with photoreactive groups, such as ultraviolet light (UV)-reactive benzophenone and visible light-reactive xanthene dye (e.g., fluorescein sodium salt, eosin Y, and rose bengal). A series of the prepared photocurable tissue adhesive glues, consisting of the photoreactive gelatin, PEGDA, and a saline solution with or without ascorbic acid as a reducing agent, were viscous solutions under warming, and their effectiveness was evaluated as hemostasis- and anastomosis-aid in cardiovascular surgery. Regardless of the type of photoreactive groups, the irradiation of the photocurable tissue adhesive glues by UV or visible light within 1 min produced water-swollen gels, which had a high adhesive strength to wet collagen film. These were due to the synergistic action of photoreactive group-initiated photo-cross-linking and photograft polymerization. An increase in the irradiation time resulted in increased gel yield and reduced water swellability. A decrease in the molecular weight of PEGDA and an increase in concentration of both gelatin and PEGDA resulted in reduced water swellability and increased tensile and burst strengths of the resultant gels. In rats whose livers were injured with a trephine in laparotomy, the bleeding spots were coated with the photocurable adhesive glue and irradiated through an optical fiber. The coated solution was immediately converted to a swollen gel. The gel was tightly adhered to the liver tissue presumably by interpenetration, and concomitantly hemostasis was completed. The anastomosis treatment with the photocurable glue in the canine abdominal or thoracic aortas incised with a knife resulted in little bleeding under pulsatile flow after declamping. Histological examination showed that the glues

Dialogue Coherence: A Generation Framework

NARCIS (Netherlands)

Beun, R.J.; Eijk, R.M. van

2007-01-01

This paper presents a framework for the generation of coherent elementary conversational sequences at the speech act level. We will embrace the notion of a cooperative dialogue game in which two players produce speech acts to transfer relevant information with respect to their commitments.

Magnetic Retraction of Bowel by Intraluminal Injectable Cyanoacrylate-Based Magnetic Glue

Directory of Open Access Journals (Sweden)

Zhigang Wang

2013-01-01

Full Text Available Magnetic retraction offers advantages over physical retraction by graspers because of reduced tissue trauma. The objectives of this study are to investigate a novel method of magnetisation of bowel segments by intraluminal injection of magnetic glue and to demonstrate the feasibility of magnetic retraction of bowel with sufficient force during minimal access surgery. Following an initial materials characterisation study, selected microparticles of stainless steel (SS410-μPs were mixed with chosen cyanoacrylate glue (Loctite 4014. During intraluminal injection of the magnetic glue using ex vivo porcine colonic segments, a magnetic probe placed at the injected site ensured that the SS410-μPs aggregated during glue polymerisation to form an intraluminal mucosally adherent coagulum. The magnetised colonic segments were retracted by magnetic probes (5 and 10 mm placed external to the bowel wall. A tensiometer was used to record the retraction force. With an injected volume of 2 mL in a particle concentration of 1 g/mL, this technique produced maximal magnetic retraction forces of 2.24 ± 0.23 N and 5.11 ± 0.34 N (, with use of 5 and 10 mm probes, respectively. The results indicate that the formation of an intraluminal coagulum based on SS410-μPs and Loctite 4014 produces sufficient magnetic retraction for bowel retraction.

Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS Inner Detector

Science.gov (United States)

Poley, L.; Bloch, I.; Edwards, S.; Friedrich, C.; Gregor, I.-M.; Jones, T.; Lacker, H.; Pyatt, S.; Rehnisch, L.; Sperlich, D.; Wilson, J.

2016-05-01

The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive used initially between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). However, this glue has several disadvantages, which motivated the search for an alternative. This paper presents a study of six ultra-violet (UV) cure glues and a glue pad for possible use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, thermal conduction and shear strength. Samples were thermally cycled, radiation hardness and corrosion resistance were also determined. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives than silver loaded glue. Results from electrical tests of first prototype modules constructed using these glues are presented.

Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS Inner Detector

International Nuclear Information System (INIS)

Poley, L.; Bloch, I.; Friedrich, C.; Gregor, I.-M.; Edwards, S.; Pyatt, S.; Wilson, J.; Jones, T.; Lacker, H.; Rehnisch, L.; Sperlich, D.

2016-01-01

The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive used initially between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). However, this glue has several disadvantages, which motivated the search for an alternative. This paper presents a study of six ultra-violet (UV) cure glues and a glue pad for possible use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, thermal conduction and shear strength. Samples were thermally cycled, radiation hardness and corrosion resistance were also determined. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives than silver loaded glue. Results from electrical tests of first prototype modules constructed using these glues are presented.

Linkage and mapping analyses of the no glue egg gene Ng in the ...

African Journals Online (AJOL)

In the silkworm, Bombyx mori, no glue egg is mainly controlled by Ng (No glue) gene, which is located on the 12th chromosome. Owning to a lack of crossing over in females, reciprocal backcrossed F1 (BC1) progenies were used for linkage analysis and mapping of the Ng gene based on the simple sequence repeats ...

Nuovi Metodi di visualizzazione geografica: l'approccio Focus+Glue+Context

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Flavio Lupia

2010-03-01

Full Text Available New cartographic visualization methods: the Focus+Glue+Context approach Focus+Glue+Context is a new cartographic visualization method specifically designed to solve the fruition problems connected with the use of mobile devices and web mapping services. The objective of the F+G+C approach is to reduce users cognitive efforts when reading a map: to do so, the area of interest is ‘highlighted’ in a lower and more detailed scale through a fisheye lens effect, while the sorrouding context, useful to the user to determine the items relationships in a map, is maintained on a higher scale.

Nuovi Metodi di visualizzazione geografica: l'approccio Focus+Glue+Context

Directory of Open Access Journals (Sweden)

Flavio Lupia

2010-03-01

Full Text Available New cartographic visualization methods:the Focus+Glue+Context approachFocus+Glue+Context is a new cartographic visualization method specifically designed to solve the fruition problems connected with the use of mobile devices and web mapping services. The objective of the F+G+C approach is to reduce users cognitive efforts when reading a map: to do so, the area of interest is ‘highlighted’ in a lower and more detailed scale through a fisheye lens effect, while the sorrouding context, useful to the user to determine the items relationships in a map, is maintained on a higher scale.

SHEAR STRENGTH IN THE GLUE LINE OF Eucalyptus sp. AND Pinus sp.WOOD

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Juliana Jerásio Bianche

Full Text Available ABSTRACT To evaluate the adhesive efficiency on the union of glued joints in a particular temperature and humidity conditions for a specified time the adhesive must be submitted to specific load tests, such as shear in the glue line. The objective of this study was to evaluate the shear strength in the glue line of Eucalyptus sp and Pinus sp.woods. Five adhesives (castor oil, sodium silicate, modified silicate, , PVA and resorcinol-formaldehyde, three weights (150 g/m2, 200 g/m2, and 250 g/m2 and two species (Eucalyptus sp. and Pinus sp. of wood were used. Twelve specimens were obtained from each repetition per treatment, corresponding to 108 specimens that were conditioned at a temperature of 23 ± 1°C and relative humidity of 50 ± 2%. The interaction between the weight and type of adhesive was significant for the shear strength in the glue line of eucalyptus wood. However, no interaction between the weight and the adhesive was found for pinus, only the isolated from the adhesive effect. Chemical bonds originated in the polymerization of resorcinol-formaldehyde adhesives and castor bi-component conferred upon these adhesives the greatest resistance in the glue line. Castor and resorcinol-formaldehyde adhesives showed the highest shear strength values in the line of glue and wood failure. Castor adhesive presented satisfactory performance for bonding of eucalyptus and pine woods.

BioGlue iceball stabilization to minimize the risk of hemorrhage during laparoscopic renal cryoablation.

Science.gov (United States)

Mues, Adam C; Graversen, Joseph A; Truesdale, Matthew D; Casazza, Cristin; Landman, Jaime

2011-08-01

To evaluate the application of a BioGlue adhesive shell to minimize iceball fracture. Iceball fracture and hemorrhage is common with laparoscopic cryoablation (LCA) of larger (>4 cm) renal tumors. Twenty large iceballs were created in porcine kidneys using 3 cryoablation probes in a nonsurvival study. Each kidney underwent an upper and lower pole ablation. One pole in each kidney was covered with 5 mL of BioGlue and the opposite pole served as a control. A double freeze-thaw cycle was performed (10 minutes freeze and 5 minutes active thaw) in both renal poles simultaneously. The probes were removed and the sites were monitored for 20 minutes under direct vision. Fracture length (mm), severity of fracture depth, severity of bleeding (absent, mild, moderate, severe), and estimated blood loss (EBL) (mL) were recorded. In the control group, the mean fracture length was 1.9 mm (range, 0-3 mm). Blood loss was absent in 10%, mild in 60%, and moderate in 30% of ablations. The mean EBL was 20.5 mL (range, 0-50 mL). For the BioGlue ablations, there were no parenchymal fractures. Blood loss was mild in 30% and absent in 70% of sites with an average EBL of 5 mL (range, 0-20). Two bleeding sites occurred as a result of subcapsular hematomas caused by initial probe placement. BioGlue application minimized the frequency and magnitude of renal fracture. EBL was lower with BioGlue application and most sites demonstrated no postablation bleeding. Further clinical study of the BioGlue shell should be performed to confirm these results. Copyright © 2011 Elsevier Inc. All rights reserved.

Fibrin glue on an aortic cusp detected by transesophageal echocardiography after valve-sparing aortic valve replacement: a case report.

Science.gov (United States)

Nakahira, Junko; Ishii, Hisanari; Sawai, Toshiyuki; Minami, Toshiaki

2015-03-07

Fibrin glue is used commonly during cardiac surgery but can behave as an intracardiac abnormal foreign body following surgery. There have been few such cases reported, and they were typically noticed only because of the resulting catastrophic cardiac conditions, such as valvular malfunction. We report a case where, for the first time, transesophageal echocardiography was used to detected fibrin glue that was adherent to the ventricular side of a patient's aortic valve immediately after aortic declamping. A 45-year-old Japanese man with Marfan syndrome underwent an aortic valve-sparing operation to treat moderate aortic valve regurgitation resulting from enlargement of his right coronary cusp. Fibrin glue was lightly applied to the suture line between the previous and new grafts. Transesophageal echocardiography performed prior to weaning from the cardiopulmonary bypass revealed mild aortic valve regurgitation in addition to a mobile membranous structure attached to the ventricular side of his aortic valve. It was identified as fibrin glue. We resolved the regurgitation by removing the fibrin glue and repeating the aortic cusp plication. The patient had no complications during recovery. Fibrin glue can act as an intracardiac foreign body and lead to a potentially fatal embolism. We demonstrated the use of transesophageal echocardiography to detect a fibrin glue-derived intracardiac abnormal foreign body and to confirm its removal. To the best of our knowledge, this is the first case where fibrin glue adherent to the aortic valve was detected by transesophageal echocardiography. These findings demonstrate the importance of using transesophageal echocardiography during cardiac surgery that involves using biological glues.

Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs

Directory of Open Access Journals (Sweden)

Đenić Nebojša

2015-01-01

Full Text Available Background/Aim. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as a local hemostatic and as a matrix for the local dosed release of antibiotics. Antibiotics addition to fibrin glue resulted in continuous diffusion into the surrounding next 4 to 7 days. The aim of this study was to create the preconditions for gunshot wounds closing without complications by the application of fibrin glue with antibiotics 24 h after primary surgical treatment. Methods. A total of 14 pigs were wounded in the gluteofemoral region by the bullet M67, initial velocity of 720 m/s. All wounded animals were surgically treated according to the principles of the warsurgery doctrine. Seven wounds were closed with primary delayed suture four days after the primary surgical treatment (traditional approach. Fibrin glue with antibiotics was introduced in seven wounds during the primary surgical treatment and primary delayed suture was done after 24 h. The macroscopic appearance and the clinical assessment of the wound were done during the primary surgical treatment and during its revision after 24 h, as well as histopathological findings at the days 4 and 7 after wounding. Results. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47 7.62 mm, and treated with fibrin glue with antibiotics after primary surgical management, were closed with primary delayed suture after 24 h. In further wound evolution there were no complications. Conclusion. Uncomplicated soft-tissue wounds caused by an automatic M70AB2 rifle may be closed primarily with delayed suture without the risk of developing complications if on revision, 24 h after primary surgery, there were no present necrotic tissues, hematoma, and any signs of infection when fibrin glue with antibiotics

Bandwidth-Tunable Fiber Bragg Gratings Based on UV Glue Technique

Science.gov (United States)

Fu, Ming-Yue; Liu, Wen-Feng; Chen, Hsin-Tsang; Chuang, Chia-Wei; Bor, Sheau-Shong; Tien, Chuen-Lin

2007-07-01

In this study, we have demonstrated that a uniform fiber Bragg grating (FBG) can be transformed into a chirped fiber grating by a simple UV glue adhesive technique without shifting the reflection band with respect to the center wavelength of the FBG. The technique is based on the induced strain of an FBG due to the UV glue adhesive force on the fiber surface that causes a grating period variation and an effective index change. This technique can provide a fast and simple method of obtaining the required chirp value of a grating for applications in the dispersion compensators, gain flattening in erbium-doped fiber amplifiers (EDFAs) or optical filters.

[Propolis. The bee glue as presented by the Graeco-Roman literature].

Science.gov (United States)

Golder, Werner

2004-01-01

The bee glue, commonly known as propolis, has been employed for medical purposes already in teh ancient world. More than 15 Greek and Roman authors report on the preparation and application of the so-called third natural product of the bees (besides honey and wax). Aristoteles described the fundamental issues of its biology in his 'Historia Animalium' correctly. The bulk of propolis is obtained from the barks of poplars. Once carried in the hives, the glue is used to stabilize the cells and honeycombs and to protect the bees against invaders and cold weather. Propolis has been chiefly employed for the preparation of ointment and plasters. For this purpose, the viscous raw material was purified, moulded and boiled. In most preparations, the bee glue was only one of many (up to 20) pharmacologically active constituents and came to five to 20% of the mixture. Only rarely, a single drug therapy was using propolis was carried out. The application of the glue was most successful in general surgery and casualties. In that respect, the ancient physicians took advantage of the anti-edematous and anti-infectious properties of the substance. Thus, it was used to treat bumps, indurations, and slow-healing wounds. Moreover, cataplasms against swollen cervical nodes and indurations of the female breast often contained propolis. Finally, bee glue proved successful for the treatment of chronic backache and pain in the hip as well as fresh injuries of muscles and tendons. In the sector of skin diseases, lichens and condylomata were found to respond well to propolis. ALl this indications have been a matter of several records. However, the successful use of propolis in diseases of the stomach and liver has ben reported solely by Alexander of Tralles (6th century AD). Not counting the internal diseases, the spectrum of indications for propolis has not substantially changed as compared to the classical antiquity. Interestingly, radiation therapists have adopted the ancient remedy and

Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs

OpenAIRE

Đenić Nebojša; Višnjić Milan; Dragović Saša; Bojanić Vladmila; Bojanić Zoran; Đurđević Dragan; Đinđić Boris; Kostov Miloš

2015-01-01

Background/Aim. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as a local hemostatic and as a matrix for the local dosed release of antibiotics. Antibiotics addition to fibrin glue resulted in continuous diffusion into the surrounding n...

Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS inner detector

International Nuclear Information System (INIS)

Poley, Luise; Bloch, Ingo; Edwards, Sam

2016-04-01

The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). This glue has several disadvantages, which motivated the search for an alternative. This paper presents a study concerning the use of six ultra-violet (UV) cure glues and a glue pad for use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, the thermal conduction and shear strength, thermal cycling, radiation hardness, corrosion resistance and shear strength tests. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives. Results from electrical tests of first prototype modules constructed using these glues are presented.

Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS inner detector

Energy Technology Data Exchange (ETDEWEB)

Poley, Luise [DESY, Zeuthen (Germany); Humboldt Univ. Berlin (Germany); Bloch, Ingo [DESY, Zeuthen (Germany); Edwards, Sam [Birmingham Univ. (United Kingdom); and others

2016-04-15

The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). This glue has several disadvantages, which motivated the search for an alternative. This paper presents a study concerning the use of six ultra-violet (UV) cure glues and a glue pad for use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, the thermal conduction and shear strength, thermal cycling, radiation hardness, corrosion resistance and shear strength tests. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives. Results from electrical tests of first prototype modules constructed using these glues are presented.

Fibrinogen and thrombin concentrations are critical for fibrin glue adherence in rat high-risk colon anastomoses

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Eliseo Portilla-de Buen

2014-04-01

Full Text Available OBJECTIVE: Fibrin glues have not been consistently successful in preventing the dehiscence of high-risk colonic anastomoses. Fibrinogen and thrombin concentrations in glues determine their ability to function as sealants, healers, and/or adhesives. The objective of the current study was to compare the effects of different concentrations of fibrinogen and thrombin on bursting pressure, leaks, dehiscence, and morphology of high-risk ischemic colonic anastomoses using fibrin glue in rats. METHODS: Colonic anastomoses in adult female Sprague-Dawley rats (weight, 250-350 g treated with fibrin glue containing different concentrations of fibrinogen and thrombin were evaluated at post-operative day 5. The interventions were low-risk (normal or high-risk (ischemic end-to-end colonic anastomoses using polypropylene sutures and topical application of fibrinogen at high (120 mg/mL or low (40 mg/mL concentrations and thrombin at high (1000 IU/mL or low (500 IU/mL concentrations. RESULTS: Ischemia alone, anastomosis alone, or both together reduced the bursting pressure. Glues containing a low fibrinogen concentration improved this parameter in all cases. High thrombin in combination with low fibrinogen also improved adherence exclusively in low-risk anastomoses. No differences were detected with respect to macroscopic parameters, histopathology, or hydroxyproline content at 5 days post-anastomosis. CONCLUSIONS: Fibrin glue with a low fibrinogen content normalizes the bursting pressure of high-risk ischemic left-colon anastomoses in rats at day 5 after surgery.

Use of tissue glue for punch grafting in vitiligo - A preliminary report

Directory of Open Access Journals (Sweden)

Ghorpade Ashok

2004-05-01

Full Text Available BACKGROUND: Minipunch grafting has been successfully used for the treatment of stable vitiligo since several years. Post-operative immobilization at certain sites such as lips, areola & infralabial folds and joints is not easy to achieve. Putting stay sutures on the lips and areolae is difficult. Grafting over the joints may require hospitalization to ensure proper immobilization, and may discourage some patients. AIM: To study the efficacy of a tissue glue for immobilization of donor grafts at the above sites during minipunch grafting. METHODS: Ten cases with stable vitiligo over the lips, areolae, below the lower lip, and over different joints had tissue glue applied to the edges between the donor grafts and the recipient wells, after the grafting. RESULTS: The grafts adhered firmly within a minute and there was no need for a cumbersome dressing. Over the lips, the patients could resume talking and drinking fluids immediately. CONCLUSION: The glue was very helpful for immobilizing the grafts at these difficult sites.

Photoproduction of the Cascade Baryons at GlueX

Science.gov (United States)

Ernst, Ashley; GlueX Collaboration

2017-09-01

Multi-strange baryons play an important role in understanding the strong interaction and despite their importance, little is known about such hyperons. Almost all knowledge of the Cascades today stems from Kaon-nucleon interactions in bubble chamber experiments performed in the 1960s and 1970s, of which only the octet and decuplet ground states, Ξ (1320) and Ξ (1530) respectively, are well established. This research uses the GlueX experiment at Jefferson Laboratory to map out the spectrum of doubly-strange Cascade resonances, as well as to measure the spin-parity for each of the detected resonances. The first physics run for GlueX has recently been completed and a clear signature of the Ξ (1320) is observed. The systematics of the Cascade spectrum will be presented motivated by prior discoveries in the N* program. This work was supported by the U.S. Department of Energy Grant DE-FG02-92ER40735 and National Science Foundation Grant 1449440.

Cross-linking by protein oxidation in the rapidly setting gel-based glues of slugs

Science.gov (United States)

Bradshaw, Andrew; Salt, Michael; Bell, Ashley; Zeitler, Matt; Litra, Noelle; Smith, Andrew M.

2011-01-01

SUMMARY The terrestrial slug Arion subfuscus secretes a glue that is a dilute gel with remarkable adhesive and cohesive strength. The function of this glue depends on metals, raising the possibility that metal-catalyzed oxidation plays a role. The extent and time course of protein oxidation was measured by immunoblotting to detect the resulting carbonyl groups. Several proteins, particularly one with a relative molecular mass (Mr) of 165×103, were heavily oxidized. Of the proteins known to distinguish the glue from non-adhesive mucus, only specific size variants were oxidized. The oxidation appears to occur within the first few seconds of secretion. Although carbonyls were detected by 2,4-dinitrophenylhydrazine (DNPH) in denatured proteins, they were not easily detected in the native state. The presence of reversible cross-links derived from carbonyls was tested for by treatment with sodium borohydride, which would reduce uncross-linked carbonyls to alcohols, but stabilize imine bonds formed by carbonyls and thus lead to less soluble complexes. Consistent with imine bond formation, sodium borohydride led to a 20–35% decrease in the amount of soluble protein with a Mr of 40–165 (×103) without changing the carbonyl content per protein. In contrast, the nucleophile hydroxylamine, which would competitively disrupt imine bonds, increased protein solubility in the glue. Finally, the primary amine groups on a protein with a Mr of 15×103 were not accessible to acid anhydrides. The results suggest that cross-links between aldehydes and primary amines contribute to the cohesive strength of the glue. PMID:21525316

Framework for Leading Next Generation Science Standards Implementation

Science.gov (United States)

Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

2017-01-01

In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

GLUE 2 deployment: Ensuring quality in the EGI/WLCG information system

International Nuclear Information System (INIS)

Burke, Stephen; Pradillo, Maria Alandes; Field, Laurence; Keeble, Oliver

2014-01-01

The GLUE 2 information model is now fully supported in the production EGI/WLCG information system. However, to make it usable and allow clients to rely on the published information it is important that the meaning is clearly defined, and that information providers and site configurations are validated to ensure as far as possible that what they publish is correct. In this paper we describe the definition of a detailed schema usage profile, the implementation of a software tool to validate published information according to the profile and the use of the tool in the production Grid, and also summarise the overall state of GLUE 2 deployment.

Physicochemical and functional properties, microstructure, and storage stability of whey protein/polyvinylpyrrolidone based glue sticks

Directory of Open Access Journals (Sweden)

Guorong Wang

2012-11-01

Full Text Available A glue stick is comprised of solidified adhesive mounted in a lipstick-like push-up tube. Whey is a byproduct of cheese making. Direct disposal of whey can cause environmental pollution. The objective of this study was to use whey protein isolate (WPI as a natural polymer along with polyvinylpyrrolidone (PVP to develop safe glue sticks. Pre-dissolved WPI solution, PVP, sucrose, 1,2-propanediol (PG, sodium stearate, defoamer, and preservative were mixed and dissolved in water at 90 oC and then molded in push-up tubes. Chemical composition, functional properties (bonding strength, glue setting time, gel hardness, extension/retraction, and spreading properties, microstructure, and storage stability of the prototypes were evaluated in comparison with a commercial control. Results showed that all WPI/PVP prototypes had desirable bonding strength and exhibited faster setting than PVP prototypes and control. WPI could reduce gel hardness and form less compact and rougher structures than that of PVP, but there was no difference in bonding strength. PVP and sucrose could increase the hygroscopicity of glue sticks, thus increasing storage stability. Finally, the optimized prototype GS3 (major components: WPI 8.0%, PVP 12.0%, 1,2-propanediol 10.0%, sucrose 10.0%, and stearic sodium 7.0% had a comparable functionality to the commercial control. Results indicated that whey protein could be used as an adhesive polymer for glue stick formulations, which could be used to bond fiber or cellulose derived substrates such as paper.

Acute nonlymphocytic leukemia in a glue sniffer.

Science.gov (United States)

Caligiuri, M A; Early, A P; Marinello, M J; Preisler, H D

1985-09-01

A 17-year-old white male with a past history of chronic inhalational abuse of plastic glue was referred to our institution for sore throat, cervical adenopathy, and an abnormal peripheral blood smear. A diagnosis of acute myelomonocytic leukemia was made and abnormalities in cytogenetic studies were demonstrated. Specific inquiry regarding this form of drug exposure should be pursued when searching for possible etiologies of malignant disease.

Towards GLUE 2: evolution of the computing element information model

International Nuclear Information System (INIS)

Andreozzi, S; Burke, S; Field, L; Konya, B

2008-01-01

A key advantage of Grid systems is the ability to share heterogeneous resources and services between traditional administrative and organizational domains. This ability enables virtual pools of resources to be created and assigned to groups of users. Resource awareness, the capability of users or user agents to have knowledge about the existence and state of resources, is required in order utilize the resource. This awareness requires a description of the services and resources typically defined via a community-agreed information model. One of the most popular information models, used by a number of Grid infrastructures, is the GLUE Schema, which provides a common language for describing Grid resources. Other approaches exist, however they follow different modeling strategies. The presence of different flavors of information models for Grid resources is a barrier for enabling inter-Grid interoperability. In order to solve this problem, the GLUE Working Group in the context of the Open Grid Forum was started. The purpose of the group is to oversee a major redesign of the GLUE Schema which should consider the successful modeling choices and flaws that have emerged from practical experience and modeling choices from other initiatives. In this paper, we present the status of the new model for describing computing resources as the first output from the working group with the aim of dissemination and soliciting feedback from the community

Effect of fibrin glue on the biomechanical properties of human Descemet's membrane.

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Shyam S Chaurasia

Full Text Available BACKGROUND: Corneal transplantation has rapidly evolved from full-thickness penetrating keratoplasty (PK to selective tissue corneal transplantation, where only the diseased portions of the patient's corneal tissue are replaced with healthy donor tissue. Descemet's membrane endothelial keratoplasty (DMEK performed in patients with corneal endothelial dysfunction is one such example where only a single layer of endothelial cells with its basement membrane (10-15 µm in thickness, Descemet's membrane (DM is replaced. It is challenging to replace this membrane due to its intrinsic property to roll in an aqueous environment. The main objective of this study was to determine the effects of fibrin glue (FG on the biomechanical properties of DM using atomic force microscopy (AFM and relates these properties to membrane folding propensity. METHODOLOGY/PRINCIPAL FINDINGS: Fibrin glue was sprayed using the EasySpray applicator system, and the biomechanical properties of human DM were determined by AFM. We studied the changes in the "rolling up" tendency of DM by examining the changes in the elasticity and flexural rigidity after the application of FG. Surface topography was assessed using scanning electron microscopy (SEM and AFM imaging. Treatment with FG not only stabilized and stiffened DM but also led to a significant increase in hysteresis of the glue-treated membrane. In addition, flexural or bending rigidity values also increased in FG-treated membranes. CONCLUSIONS/SIGNIFICANCE: Our results suggest that fibrin glue provides rigidity to the DM/endothelial cell complex that may aid in subsequent manipulation by maintaining tissue integrity.

Effect of Fibrin Glue on the Biomechanical Properties of Human Descemet's Membrane

Science.gov (United States)

Chaurasia, Shyam S.; Champakalakshmi, Ravi; Li, Ang; Poh, Rebekah; Tan, Xiao Wei; Lakshminarayanan, Rajamani; Lim, Chwee T.; Tan, Donald T.; Mehta, Jodhbir S.

2012-01-01

Background Corneal transplantation has rapidly evolved from full-thickness penetrating keratoplasty (PK) to selective tissue corneal transplantation, where only the diseased portions of the patient's corneal tissue are replaced with healthy donor tissue. Descemet's membrane endothelial keratoplasty (DMEK) performed in patients with corneal endothelial dysfunction is one such example where only a single layer of endothelial cells with its basement membrane (10–15 µm in thickness), Descemet's membrane (DM) is replaced. It is challenging to replace this membrane due to its intrinsic property to roll in an aqueous environment. The main objective of this study was to determine the effects of fibrin glue (FG) on the biomechanical properties of DM using atomic force microscopy (AFM) and relates these properties to membrane folding propensity. Methodology/Principal Findings Fibrin glue was sprayed using the EasySpray applicator system, and the biomechanical properties of human DM were determined by AFM. We studied the changes in the “rolling up” tendency of DM by examining the changes in the elasticity and flexural rigidity after the application of FG. Surface topography was assessed using scanning electron microscopy (SEM) and AFM imaging. Treatment with FG not only stabilized and stiffened DM but also led to a significant increase in hysteresis of the glue-treated membrane. In addition, flexural or bending rigidity values also increased in FG-treated membranes. Conclusions/Significance Our results suggest that fibrin glue provides rigidity to the DM/endothelial cell complex that may aid in subsequent manipulation by maintaining tissue integrity. PMID:22662156

The use of snake venom derived fibrin glue in hysterorrhaphy of ovine caesarean surgery

OpenAIRE

CHALHOUB, M.; PRESTES, N. C.; LOPES, M. D.; ROCHA, N. S.; THOMAZINI-SANTOS, I. A.; MENDES-GIANNINI, M.J.

2000-01-01

Fibrin glue has been used on its own or in conjunction with suturing materials to promote hemostasis, reduce adherence, strengthen the wound site, and improve healing. Snake venom derived fibrin glue was evaluated as an alternative to conventional uterine suturing after ovine caesarean surgery. Twenty-eight pregnant ewes of known mating date were used. The animals submitted to conventional caesarean sections showed a better wound healing process. As expected, all the operated animals had reta...

Uncertainty assessment of integrated distributed hydrological models using GLUE with Markov chain Monte Carlo sampling

DEFF Research Database (Denmark)

Blasone, Roberta-Serena; Madsen, Henrik; Rosbjerg, Dan

2008-01-01

uncertainty estimation (GLUE) procedure based on Markov chain Monte Carlo sampling is applied in order to improve the performance of the methodology in estimating parameters and posterior output distributions. The description of the spatial variations of the hydrological processes is accounted for by defining......In recent years, there has been an increase in the application of distributed, physically-based and integrated hydrological models. Many questions regarding how to properly calibrate and validate distributed models and assess the uncertainty of the estimated parameters and the spatially......-site validation must complement the usual time validation. In this study, we develop, through an application, a comprehensive framework for multi-criteria calibration and uncertainty assessment of distributed physically-based, integrated hydrological models. A revised version of the generalized likelihood...

A comparative study of tissue glue and vicryl suture for conjunctival and scleral closure in conventional 20-gauge vitrectomy.

Science.gov (United States)

Batman, C; Ozdamar, Y; Mutevelli, S; Sonmez, K; Zilelioglu, G; Karakaya, J

2009-06-01

To describe the use of tissue glue to close scleral and conjunctival wounds, and to compare the clinical outcomes using tissue glue and vicryl suture for closing these areas in conventional 20-gauge (G) vitrectomy. Thirty eyes of 30 patients were included in this study. The indications for vitreoretinal surgery were diabetic vitreous haemorrhage with severe vitreoretinal traction in 10 eyes, retinal detachment and proliferative vitreoretinopathy in 14 eyes, and vitreous opacity in 6 eyes. Tissue glue (Tisseel, Baxter AG Industries, Vienna, Austria) was used to attach scleral and conjunctival wounds in 15 eyes and vicryl sutures in 15 eyes. The patients were allotted into two subgroups as tissue glue group (TG) and vicryl suture group (VG). The sclerotomy sites were evaluated with ultrasound biomicroscopy (UBM) postoperatively in TG. Follow-up period was 2 months. The groups were statistically compared for ocular signs and symptoms by Mann-Whitney U-test. No scleral wound leakage and conjunctival reattachment were observed at the end of the surgical procedure and during the follow-up period. No adverse effects were seen in TG. Abnormal fibrous ingrowth was not detected at the sclerotomy sites by means of UBM in TG. Patient comfort was significantly higher in TG than VG (P<0.05). Tissue glue has no adverse effects on ocular tissue and can be used as a substitute for suture materials, and the use of tissue glue decreases patient symptoms during the postoperative period after 20-G vitrectomy. Tissue glue can enable to perform sutureless surgery in the conventional 20-G vitrectomy.

Tests of optical glues for the PANDA electromagnetic calorimeter

NARCIS (Netherlands)

Dbeyssi, A.; Tomasi-Gustafsson, E.; Hennino, T.; Imre, M.; Kunne, R.; Le Galliard, C.; Marchand, D.; Maroni, A.; Ramstein, B.; Rosier, P.; Bremer, D.; Dormenev, V.; Eissner, T.; Kuske, T.; Novotny, R.; Moeini, H.; Bondarenko, O.; Kavatsyuk, M.; Loehner, H.; Messchendorp, G.; Tambave, G.

2013-01-01

This paper reports on the results of tests for low temperature applications of two commercial optical glues in the electromagnetic calorimeter of PANDA at FAIR. Mechanical, thermal and optical properties are presented, as well as radiation hardness to photon and proton radiation. (C) 2013 Elsevier

Properties of invariant modelling and invariant glueing of vector fields

International Nuclear Information System (INIS)

Petukhov, V.R.

1987-01-01

Invariant modelling and invariant glueing of both continuous (rates and accelerations) and descrete vector fields, gradient and divergence cases are considered. The following appendices are discussed: vector fields in crystals, crystal disclinations, topological charges and their fields

Endoscopic use of cyanoacrylate glue in the treatment of urethral fistula

Directory of Open Access Journals (Sweden)

Andre Ramos Sorgi Macedo

2013-07-01

Full Text Available Purpose The aim of this video is to demonstrate an endoscopic and minimally invasive repair of an urethrocutaneous fistula with cyanoacrylate glue. Materials and Methods: A 56 year-old-man with post-infectious urethral stricture and recurrent perineal abscess formation due to urethral fistulas. Results The operative time was 60 minutes, no major complications were observed perioperatively and postoperatively. At a follow-up time of 6 months the patient had no evidence of recurrent fistula and abscess formation. CONCLUSIONS The endoscopic use of cyanoacrylate glue represents a safe and minimally invasive approach that might be offered as a first line option for the treatment of urinary fistulas in selected patients, especially those with narrow and long tracts.

Glasses, Coatings, Glues and Gamma-ray Irradiation

International Nuclear Information System (INIS)

Barcala, J.M.; Fernandez, M. G.; Ferrando, A.; Fuentes, J.; Josa, M. I.; Molinero, A.; Oller, J. C.; Arce, P.; Calvo, E.; Figueroa, C. F.; Rodrigo, T.; Vila, I.; Virto, A. L.; Beigveder, J. M.; Genova, I.; Perez, G.; Ruiz, J. A.

2001-01-01

Most of the alignment systems for LHC experiments use optomechanical elements confirming a network of points that are monitored by laser beams. LHC experiments, working at the expected nominal luminosity, will induce an extremely high irradiation. basic components such as glasses, coatings and glues may change and their performance may degrade significantly. We have tested various components and identified some of them that can stand 10 years of LHC operation. (Author) 11 refs

Glasses, Coatings, Glues and Gamma-ray Irradiation

Energy Technology Data Exchange (ETDEWEB)

Barcala, J.M.; Fernandez, M. G.; Ferrando, A.; Fuentes, J.; Josa, M. I.; Molinero, A.; Oller, J. C. [Ciemat. Madrid (Spain); Arce, P.; Calvo, E.; Figueroa, C. F.; Rodrigo, T.; Vila, I.; Virto, A. L. [Universidad de Cantabria. Santander (Spain); Beigveder, J. M.; Genova, I.; Perez, G.; Ruiz, J. A. [CIDA. Madrid (Spain)

2001-07-01

Most of the alignment systems for LHC experiments use optomechanical elements confirming a network of points that are monitored by laser beams. LHC experiments, working at the expected nominal luminosity, will induce an extremely high irradiation. basic components such as glasses, coatings and glues may change and their performance may degrade significantly. We have tested various components and identified some of them that can stand 10 years of LHC operation. (Author) 11 refs.

Successful Endoscopic Management of Non-Healing Perforated Duodenal Ulcer with Polyglycolic Acid Sheet and Fibrin Glue.

Science.gov (United States)

Mishiro, Tsuyoshi; Shibagaki, Kotaro; Matsuda, Kayo; Fukuyama, Chika; Okada, Mayumi; Mikami, Hironobu; Izumi, Daisuke; Yamashita, Noritsugu; Okimoto, Eiko; Fukuda, Naoki; Aimi, Masahito; Fukuba, Nobuhiko; Oshima, Naoki; Takanashi, Toshihiro; Matsubara, Takeshi; Ishimura, Norihisa; Ishihara, Shunji; Kinoshita, Yoshikazu

2016-08-01

In recent years, treatment techniques in which polyglycolic acid sheets are applied to various situations with fibrin glue have exhibited great clinical potential, and previous studies have reported safety and efficacy. We describe closure of a non-healing perforated duodenal ulcer with the use of a polyglycolic acid sheet and fibrin glue in an elderly patient who was not a candidate for surgery.

Fibrin glue mixed with platelet-rich fibrin as a scaffold seeded with dental bud cells for tooth regeneration.

Science.gov (United States)

Yang, Kai-Chiang; Wang, Chun-Hao; Chang, Hao-Hueng; Chan, Wing P; Chi, Chau-Hwa; Kuo, Tzong-Fu

2012-11-01

Odontogenesis is a complex process with a series of epithelial-mesenchymal interactions and odontogenic molecular cascades. In tissue engineering of teeth from stem cells, platelet-rich fibrin (PRF), which is rich in growth factors and cytokines, may improve regeneration. Accordingly, PRF was added into fibrin glue to enrich the microenvironment with growth factors. Unerupted second molar tooth buds were harvested from miniature swine and cultured in vitro for 3 weeks to obtain dental bud cells (DBCs). Whole blood was collected for the preparation of PRF and fibrin glue before surgery. DBCs were suspended in fibrin glue and then enclosed with PRF, and the DBC-fibrin glue-PRF composite was autografted back into the original alveolar sockets. Radiographic and histological examinations were used to identify the regenerated tooth structure 36 weeks after implantation. Immunohistochemical staining was used to detect proteins specific to tooth regeneration. One pig developed a complete tooth with crown, root, pulp, enamel, dentin, odontoblast, cementum, blood vessels, and periodontal ligaments in indiscriminate shape. Another animal had an unerupted tooth that expressed cytokeratin 14, dentin matrix protein-1, vascular endothelial growth factor, and osteopontin. This study demonstrated, using autogenic cell transplantation in a porcine model, that DBCs seeded into fibrin glue-PRF could regenerate a complete tooth. Copyright © 2011 John Wiley & Sons, Ltd.

A Test Generation Framework for Distributed Fault-Tolerant Algorithms

Science.gov (United States)

Goodloe, Alwyn; Bushnell, David; Miner, Paul; Pasareanu, Corina S.

2009-01-01

Heavyweight formal methods such as theorem proving have been successfully applied to the analysis of safety critical fault-tolerant systems. Typically, the models and proofs performed during such analysis do not inform the testing process of actual implementations. We propose a framework for generating test vectors from specifications written in the Prototype Verification System (PVS). The methodology uses a translator to produce a Java prototype from a PVS specification. Symbolic (Java) PathFinder is then employed to generate a collection of test cases. A small example is employed to illustrate how the framework can be used in practice.

CT-guided percutaneous injection of the fibrin glue by 'double needle' technique for the treatment of sacral cysts

International Nuclear Information System (INIS)

Wang Ganggang; Chen Long; Yang Chao; Ni Caifang

2013-01-01

Objective: To analyze the efficacy and safety of CT-guided percutaneous injection of the fibrin glue by 'double needle' technique to treat sacral cyst. Methods: Clinical data of 20 cases with 'double-needle' injection of fibrin glue technology to treat sacral cyst were retrospectively analyzed. All patients had varying degrees of sacral nerve root compression symptoms. The treatment for sacral cyst was carried out after clear diagnosis was made. On the basis of CT-guided percutaneous injection of fibrin glue, the improved CT-guided percutaneous injection of fibrin glue by 'double-needle' technique was used to treat these patients. The average dose of fibrin glue was (5.9 ± 2.4) ml. The clinical results of improvement as to pain and neurological function were evaluated after follow-up of an average of 17 months. The assessment criteria were as follows: excellent, complete resolution of signs and symptoms, with the patient returning to his or her regular employment and no recurrence of cysts during 1 year of follow-up, good, symptoms and signs in the legs and perineal region resolved but with persistent pain in the lumbosacral region, which did not interfere with the patient's regular work (the cysts did not recur for 6 months during follow-up), fair, no improvement in clinical symptoms, but a decrease in cyst size on the imaging study, poor, no improvement in clinical symptoms and no observed changes in cyst size in imaging studies or recurrence. Results: Most patients experienced some degree of pain relief and functional improvement after fibrin glue therapy, with most experiencing complete or marked resolution of clinical symptoms. Nine patients reported excellent recovery, 8 reported good recovery, 2 reported fair recovery, and 1 reported poor recovery. The overall percentage of positive outcomes (excellent and good recovery) was 85%. No serious postoperative complications were discovered. Conclusions: CT guided percutaneous injection of the fibrin glue by

SU-F-T-141: Proton Dose Validation in a Phantom Beyond TRUFILL N-BCA Embolization Glue

International Nuclear Information System (INIS)

Mandapaka, A; Ghebremedhin, A; Patyal, B; Linda, Loma

2016-01-01

Purpose: To validate the treatment planning system predicted proton dose beyond a heterogeneity (n-BCA glue) by making a measurement in a custom acrylic phantom. Methods: A custom cubic acrylic phantom was designed for this experiment. A container was designed to fit in the phantom. This container was filled with TRUFILL™ n-Butyl Cyanoacrylate(n-BCA) glue. When the container was placed in the phantom, its center was at a distance of 7.4cm from the entrance. This depth allows us to make measurements around the center of modulation of a 126 MeV proton beam with a 3cm spread-out-Bragg peak. To make measurements at other beam energies, additional acrylic can be added in front of the phantom, to adjust the depth of the heterogeneity. A diamond detector was cross calibrated against a standard cylindrical ion chamber in a 126MeV beam. The diamond detector was then used to make dose measurements beyond the inhomogeneity. The measurement was repeated with the container filled with water. Several measurements were made at each setup, to check reproducibility of measurements. Results: For the same number of Tic3R1 counts, the dose measured with the diamond detector beyond n-BCA glue was 1.053 times the dose measured beyond the water filled container. This result is in agreement with the measured stopping power of glue (1.06). These measurements were in agreement with the dose predicted by the treatment planning system when the electron density of the heterogeneity was replaced with 1.06 before the dose calculation. Conclusion: Our initial measurements validate the dose predicted by our treatment plan in the presence of heterogeneity in a phantom. The material tested (n-BCA glue) is commonly used in the treatment of AVM’s prior to an SRS treatment. An error in dose predicted by the treatment plan in the presence of the glue can be detrimental in a single fraction high dose SRS treatment I received the n-BCA liquid embolic system samples from Codman and Shurtleff, Inc.

SU-F-T-141: Proton Dose Validation in a Phantom Beyond TRUFILL N-BCA Embolization Glue

Energy Technology Data Exchange (ETDEWEB)

Mandapaka, A; Ghebremedhin, A; Patyal, B; Linda, Loma [University Medical Center, Loma Linda, CA (United States)

2016-06-15

Purpose: To validate the treatment planning system predicted proton dose beyond a heterogeneity (n-BCA glue) by making a measurement in a custom acrylic phantom. Methods: A custom cubic acrylic phantom was designed for this experiment. A container was designed to fit in the phantom. This container was filled with TRUFILL™ n-Butyl Cyanoacrylate(n-BCA) glue. When the container was placed in the phantom, its center was at a distance of 7.4cm from the entrance. This depth allows us to make measurements around the center of modulation of a 126 MeV proton beam with a 3cm spread-out-Bragg peak. To make measurements at other beam energies, additional acrylic can be added in front of the phantom, to adjust the depth of the heterogeneity. A diamond detector was cross calibrated against a standard cylindrical ion chamber in a 126MeV beam. The diamond detector was then used to make dose measurements beyond the inhomogeneity. The measurement was repeated with the container filled with water. Several measurements were made at each setup, to check reproducibility of measurements. Results: For the same number of Tic3R1 counts, the dose measured with the diamond detector beyond n-BCA glue was 1.053 times the dose measured beyond the water filled container. This result is in agreement with the measured stopping power of glue (1.06). These measurements were in agreement with the dose predicted by the treatment planning system when the electron density of the heterogeneity was replaced with 1.06 before the dose calculation. Conclusion: Our initial measurements validate the dose predicted by our treatment plan in the presence of heterogeneity in a phantom. The material tested (n-BCA glue) is commonly used in the treatment of AVM’s prior to an SRS treatment. An error in dose predicted by the treatment plan in the presence of the glue can be detrimental in a single fraction high dose SRS treatment I received the n-BCA liquid embolic system samples from Codman and Shurtleff, Inc.

Role of cyanoacrylate glue therapy in enteral SEMS bleeding - A nightmare

Directory of Open Access Journals (Sweden)

Virukalpatti Goparathinam Mohanprasad

2013-01-01

Full Text Available Over the past century, the use of stents has evolved to a point where they are now used extensively throughout the gastrointestinal tract. Endoscopic stenting has become widely used for treatment of gastrointestinal and hepatobiliary strictures. Metallic stents are deployed in malignant strictures as a palliative procedure. Adverse events of stenting include perforation, migration, bleeding, occlusion, and pain. Finally, the use of multidisciplinary teams which include endoscopists, interventional radiologists, and surgeons allows for the exchange of ideas and procedural planning necessary for successful innovation. We present a case of successful cessation of bleeding by using cyanoacrylate glue therapy in post-enteral self-expandable metallic stent bleeding. In conclusion, glue therapy may also be considered as a mode of treatment other than conservative approach and angiographic coil embolization.

Lifetime Improvement of Organic Light Emitting Diodes using LiF Thin Film and UV Glue Encapsulation

Science.gov (United States)

Huang, Jian-Ji; Su, Yan-Kuin; Chang, Ming-Hua; Hsieh, Tsung-Eong; Huang, Bohr-Ran; Wang, Shun-Hsi; Chen, Wen-Ray; Tsai, Yu-Sheng; Hsieh, Huai-En; Liu, Mark O.; Juang, Fuh-Shyang

2008-07-01

This work demonstrates the use of lithium fluoride (LiF) as a passivation layer and a newly developed UV glue for encapsulation on the LiF passivation layer to enhance the stability of organic light-emitting devices (OLEDs). Devices with double protective layers showed a 25-fold increase in operational lifetime compared to those without any packaging layers. LiF has a low melting point and insulating characteristics and it can be adapted as both a protective layer and pre-encapsulation film. The newly developed UV glue has a fast curing time of only 6 s and can be directly spin-coated onto the surface of the LiF passivation layer. The LiF thin film plus spin-coated UV glue is a simple packaging method that reduces the fabrication costs of OLEDs.

Clinical experience of intrapleural administration of fibrin glue for secondary pneumothorax with advanced lung cancer

International Nuclear Information System (INIS)

Nishino, Takeshi; Takizawa, Hiromitsu; Yoshida, Mitsuteru; Kawakami, Yukikiyo; Sakiyama, Shoji; Kondo, Kazuya

2014-01-01

Secondary pneumothorax with advanced lung cancer is an intractable and serious pathosis, which directly aggravates patients' Quality of Life (QOL) and prognosis. We first select the intrapleural administration of fibrin glue for secondary pneumothorax with advanced lung cancer. From April 2009 to May 2012, we encountered 5 patients who developed secondary pneumothorax during treatment for advanced lung cancer. Their average age was 60.8 years old, and 4 of them had squamous cell carcinoma, 1 had adenocarcinoma, and all had unresectable advanced lung cancer. In 4 of them, the point of air leakage could be detected by pleurography, and leakage could be stopped by the intrapleural administration of fibrin glue. All of them could receive chemotherapy or radiotherapy after treatment for secondary pneumothorax. The intrapleural administration of fibrin glue may be an effective and valid treatment for intractable secondary pneumothorax with advanced lung cancer. (author)

Glue-Sniffing: A Comparison Study of Sniffers and Non-Sniffers.

Science.gov (United States)

Jansen, P.; And Others

1992-01-01

Compared 22 glue sniffers and 22 nonsniffers from group of street children and adolescents living in supervised shelters. Found no statistically significant differences between groups on cognitive measures or biographical features. Shelter staff rated sniffers as significantly more disturbed in their relationships with others, although…

Mussel glue protein has an open conformation.

Science.gov (United States)

Williams, T; Marumo, K; Waite, J H; Henkens, R W

1989-03-01

Both native glue protein from marine mussels and a synthetic nonhydroxylated analog were analyzed by far-uv CD under a variety of conditions. Analysis of the CD spectra using various models strongly suggest a primarily random coil structure for both forms of the protein, a fact also supported by the absence of spectral change for the glue protein upon dilution into 6 M guanidine hydrochloride. The nonhydroxylated analog, which consists of 20 repeats of the peptide sequence Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys, was further characterized by enzyme modification using mushroom tyrosinase. Enzymatic hydroxylation of tyrosines was found to be best fit by a model containing two rate constants, 5.6 (+/- 0.6) X 10(-3) and 7.2 (+/- 0.3) X 10(-2) min-1. At equilibrium, HPLC analysis of digests showed nearly 100% conversion of Tyr-9 and only 15 to 35% conversion of Tyr-5. The Chou and Fasman rules for predicting structure were applied to the repeat sequence listed above. The rules predict the absence of alpha helix and beta pleated sheets in the structure of this peptide. On the other hand, beta turns are predicted to be present with Tyr-5 being in the region of highest probability. These data suggest that the protein in solution has only a small amount of secondary structure.

Endoscopic ultrasound-guided coil or glue injection in post-cyanoacrylate gastric variceal re-bleed.

Science.gov (United States)

Mukkada, Roy J; Antony, Rajesh; Chooracken, Mathew J; Francis, Jose V; Chettupuzha, Antony P; Mathew, Pradeep G; Augustine, Philip; Koshy, Abraham

2018-04-09

N-butyl-cyanoacrylate injection is recommended in bleeding/recently bled gastric varices. However, cyanoacrylate injection is associated with re-bleed in 25% to 50% of patients. Endoscopic ultrasound (EUS)-guided coil application is an emerging treatment modality for bleeding gastric varices. The aim of this study was to compare EUS-guided coil application combined with or without cyanoacrylate glue injection to injection alone in post-glue gastric variceal re-bleed. A retrospective analysis of a prospectively maintained database was performed. Thirty patients who re-bled after cyanoacrylate injection and who had EUS-guided coil application to gastric varices were included. The comparison was done with data of 51 patients who had only repeat cyanoacrylate injection. Both groups had a follow up for 12 months. EUS-guided coil application was done under endosonographic guidance. A single coil was placed in 7, two coils in each of 13 patients, three in 5, four in 3, five in one, and 6 coils in one patient. In addition, cyanoacrylate glue injection was given in 15 patients. Eight patients had repeat EUS-guided coil application 1 month later. Re-bleed and mortality were assessed. Coilng: Six out of 30 (20%) patients re-bled during follow up of 9 to 365 days. Three out of 30 (10%) died. One patient died 9 days after the procedure due to acute respiratory distress syndrome, one died 4 months after the procedure due to a re-bleed and one 5 months after the procedure due to spontaneous bacterial peritonitis. Glue only: 26/51 (51%) re-bled during follow up of 45 to 365 days. EUS-guided coil application resulted in significantly less re-bleed than glue-only (Kaplan-Meir survival analysis with log-rank test, z = 5.4, p guided coil application with/without cyanoacrylate injection for the obliteration of gastric varices is effective for post-cyanoacrylate gastric variceal re-bleed.

Gravity: The Glue of the Universe. History and Activities.

Science.gov (United States)

Gilbert, Harry; Smith, Diana Gilbert

This book presents a story of the history of gravity, the glue of the universe, and is based on two premises: (1) an understanding of mathematics is not required to grasp the concepts and implications of relativity; and (2) relativity has altered forever the perceptions of gravity, space, time, and how the universe works. A narrative text section…

Hypokalemic muscular paralysis causing acute respiratory failure due to rhabdomyolysis with renal tubular acidosis in a chronic glue sniffer.

Science.gov (United States)

Kao, K C; Tsai, Y H; Lin, M C; Huang, C C; Tsao, C Y; Chen, Y C

2000-01-01

A 34-year-old male was admitted to the emergency department with the development of quadriparesis and respiratory failure due to hypokalemia after prolonged glue sniffing. The patient was subsequently given mechanical ventilatory support for respiratory failure. He was weaned from the ventilator 4 days later after potassium replacement. Toluene is an aromatic hydrocarbon found in glues, cements, and solvents. It is known to be toxic to the nervous system, hematopoietic system, and causes acid-base and electrolyte disorders. Acute respiratory failure with hypokalemia and rhabdomyolysis with acute renal failure should be considered as potential events in a protracted glue sniffing.

Staple line reinforcement with fleece-coated fibrin glue (TachoComb) after thoracoscopic bullectomy for the treatment of spontaneous pneumothorax

International Nuclear Information System (INIS)

Muramatsu, Takashi; Ohmori, Kazumitsu; Shimamura, Mie; Furuichi, Motohiko; Takeshita, Shinji; Negishi, Nanao

2007-01-01

We investigated the cause of pneumothorax recurrence after thoracoscopic surgery and the effectiveness of staple line reinforcement with fleece-coated fibrin glue (TachoComb) in the prevention of postoperative pneumothorax recurrence. From April 3, 1992 to the end of December 2005, thoracoscopic bullectomy was performed on 499 patients of primary spontaneous pneumothorax. The causes of recurrence were investigated on 39 patients on the basis of surgical observations, preoperative chest computed tomography, and so on. The most common cause was new bulla formation (37 cases), 19 of which were apparently related to the staple line (within 1 cm of the staple lines) and 15 of which were not related to the staple line. After 2000, we stopped using forceps to grasp lungs and we have reinforced the staple line by applying fleece-coated fibrin glue. The staple line reinforced with fleece-coated fibrin glue, or sprayed with fibrin glue solution and the untreated group (bullectomy only with staples) were compared, and the recurrence rates were 1.22%, 7.25%, and 10.00%, respectively (P=0.0006021). The recurrence rate after thoracoscopic bullectomy with fleece-coated fibrin glue was significantly lowered and we consider this procedure to be the treatment of choice for the management of spontaneous pneumothorax. (author)

Towards GLUE2 evolution of the computing element information model

CERN Document Server

Andreozzi, S; Field, L; Kónya, B

2008-01-01

A key advantage of Grid systems is the ability to share heterogeneous resources and services between traditional administrative and organizational domains. This ability enables virtual pools of resources to be created and assigned to groups of users. Resource awareness, the capability of users or user agents to have knowledge about the existence and state of resources, is required in order utilize the resource. This awareness requires a description of the services and resources typically defined via a community-agreed information model. One of the most popular information models, used by a number of Grid infrastructures, is the GLUE Schema, which provides a common language for describing Grid resources. Other approaches exist, however they follow different modeling strategies. The presence of different flavors of information models for Grid resources is a barrier for enabling inter-Grid interoperability. In order to solve this problem, the GLUE Working Group in the context of the Open Grid Forum was started. ...

Using the DP-190 glue for adhesive attachment of a large space mirror and its rim

Science.gov (United States)

Vlasenko, Oleg; Zverev, Alexey; Sachkov, Mikhail

2014-07-01

The glue DP-190 is widely used for adhesive attachment of astrositall (zerodur) lightweight large-size space astronomical mirrors (diameter of 1.7 m and more) with elements of their frames of invar. Peculiarities of physicalmechanical behavior of the glue DP-190 when exposed to the environment during the ground operation and in orbit cause instability of the reflective surface quality of mirrors. In this report we show that even a small (around 1%-5%) volumetric deformation of a cylindrical adhesive layer with a thickness of 0.8 mm between the mirror and the rim element causes significant mirrors deformation. We propose to use adhesive layer of special form that allows to reduce volumetric deformations of the glue DP-190 up to three times. Here we present results based on primary mirror tests of the WSO-UV project.

[The influence of biological compatibility of the cyanoacrylate glue on regeneration of the cartilaginous tissue].

Science.gov (United States)

Semenov, F V; Skibitskaya, N F

The objective of the present study was to evaluate the possibility of the application of the cyanoacrylate-based glue for the strengthening of the reconstructed elements of the middle ear and its influence on the regeneration of the cartilaginous tissue. We used the cartilaginous tissue from the auricles of the male California rabbits as a model. The cartilage was destroyed in a standard press. Half of the cartilage thus fragmented was implanted into the left auricle. The remaining part was mixed up with the cyanoacrylate glue and implanted into the right auricle of the same animal. The implanted material was used for the morphological study on day 10, within 1 and 2 months after the beginning of the experiment. The results of the study confirm the absence of the toxic action of the biologically compatible cyanoacrylate-based glue on the regeneration of the cartilaginous and connective tissues which suggests the possibility of its application for the surgical treatment of the diseases of the middle ear.

Determining characteristic principal clusters in the “cluster-plus-glue-atom” model

International Nuclear Information System (INIS)

Du, Jinglian; Wen, Bin; 2NeT Lab, Wilfrid Laurier University, Waterloo, 75 University Ave West, Ontario N2L 3C5 (Canada))" data-affiliation=" (M2NeT Lab, Wilfrid Laurier University, Waterloo, 75 University Ave West, Ontario N2L 3C5 (Canada))" >Melnik, Roderick; Kawazoe, Yoshiyuki

2014-01-01

The “cluster-plus-glue-atom” model can easily describe the structure of complex metallic alloy phases. However, the biggest obstacle limiting the application of this model is that it is difficult to determine the characteristic principal cluster. In the case when interatomic force constants (IFCs) inside the cluster lead to stronger interaction than the interaction between the clusters, a new rule for determining the characteristic principal cluster in the “cluster-plus-glue-atom” model has been proposed on the basis of IFCs. To verify this new rule, the alloy phases in Cu–Zr and Al–Ni–Zr systems have been tested, and our results indicate that the present new rule for determining characteristic principal clusters is effective and reliable

A life-cycle based decision-making framework for electricity generation system planning

Energy Technology Data Exchange (ETDEWEB)

Norrie, S.J.; Fang, L. [Ryerson Polytechnic Univ., Toronto, ON (Canada). Environmental Applied Science and Management Graduate Program

2006-07-01

This paper proposed a framework for the consideration of multiple objectives in the long-term planning of electricity generation systems. The framework was comprised of 3 components: (1) information based on life-cycle inventories of electricity generation technologies; (2) a set of alternative scenarios to be evaluated and ranked using the framework; and (3) stakeholder values for decision objectives. Scenarios were developed to represent a set of future conditions, and values were derived through the use of questionnaires. Planning for electricity generation in Ontario was selected as a test case for the DM framework. Three scenarios were presented: (1) a business as usual scenario characterized by large, central power plants; (2) a mix of central power plants, distributed generation, and advanced conventional fuel technologies; and (3) small-scale distributed and renewable energy sources and aggressive demand-side management. The life-cycle based information from the scenario evaluation was used to estimate the performance of each scenario on the established decision criteria. Results showed that scenario 3 was the closest to achieving the fundamental objectives according to the decision criteria. It was concluded that the DM framework showed that the use of holistic environmental information and preferential information for multiple objectives can be integrated into a framework that openly and consistently evaluates a set of alternative scenarios. 31 refs., 7 tabs., 4 figs.

Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal® FS system, and polyglycolic acid sheets as wound coverings after oral surgery.

Science.gov (United States)

Kouketsu, Atsumu; Nogami, Shinnosuke; Yamada-Fujiwara, Minami; Nagai, Hirokazu; Yamauchi, Kensuke; Mori, Shiro; Miyashita, Hitoshi; Kawai, Tadashi; Matsui, Aritsune; Kataoka, Yoshihiro; Satomi, Norihisa; Ezoe, Yushi; Abe, Satoko; Takeda, Yuri; Tone, Takeshi; Hirayama, Bunnichi; Kurobane, Tsuyoshi; Tashiro, Kazuki; Yanagisawa, Yuta; Takahashi, Tetsu

2017-09-01

The CryoSeal ® FS System has been recently introduced as an automated device for the production of complete fibrin glue from autologous plasma, rather than from pool allogenic or cattle blood, to prevent viral infection and allergic reaction. We evaluated the effectiveness of complete autologous fibrin glue and polyglycolic acid (PGA) sheet wound coverings in mucosa defect oral surgery. Postoperative pain, scar contracture, ingestion, tongue dyskinesia, and postoperative bleeding were evaluated in 12 patients who underwent oral (including the tongue) mucosa excision, and received a PGA sheet and an autologous fibrin glue covering. They were compared with 12 patients who received a PGA sheet and commercial allogenic fibrin glue. All cases in the complete autologous fibrin glue group demonstrated good wound healing without complications such as local infection or incomplete cure. All evaluated clinical measures in this group were similar or superior to the commercial allogenic fibrin glue group. Coagulation and adhesion quality achieved with this method was comparable to that with a PGA sheet and commercial fibrin glue. Covering oral surgery wounds with complete autologous fibrin glue produced by an automated device was convenient, safe, and reduced the risk of viral infection and allergic reaction associated with conventional techniques. Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty.

Science.gov (United States)

Sun, Ping; Cheng, Xiang; Deng, Shichang; Hu, Qinggang; Sun, Yi; Zheng, Qichang

2017-02-07

Chronic pain following mesh-based inguinal hernia repair is frequently reported, and has a significant impact on quality of life. Whether mesh fixation with glue can reduce chronic pain without increasing the recurrence rate is still controversial. To determine whether tissue adhesives can reduce postoperative complications, especially chronic pain, with no increase in recurrence rate, compared with sutures for mesh fixation in Lichtenstein hernia repair. We searched the following electronic databases with no language restrictions: the Cochrane Central Register of Controlled Trials (CENTRAL; issue 4, 2016) in the Cochrane Library (searched 11 May 2016), MEDLINE Ovid (1986 to 11 May 2016), Embase Ovid (1986 to 11 May 2016), Science Citation Index (Web of Science) (1986 to 11 May 2016), CBM (Chinese Biomedical Database), CNKI (China National Knowledge Infrastructure), VIP (a full-text database in China), Wanfang databases. We also checked reference lists of identified papers (included studies and relevant reviews). We included all randomised and quasi-randomised controlled trials comparing glue versus sutures for mesh fixation in Lichtenstein hernia repair. Cluster-RCTs were also eligible. Two review authors extracted data and assessed the risk of bias independently. Dichotomous outcomes were expressed as odds ratio (OR) with 95% confidence intervals (CI). Continuous outcomes were expressed as mean differences (MD) with 95% CIs. Twelve trials with a total of 1932 participants were included in this review. The overall postoperative chronic pain in the glue group was reduced by 37% (OR 0.63, 95% CI 0.44 to 0.91; 10 studies, 1418 participants, low-quality evidence) compared with the suture group. However, the results changed when we conducted subgroup analysis with regard to the type of mesh. Subgroup analysis of included studies using lightweight mesh showed the reduction of chronic pain was less profound and insignificant (OR 0.77, 95% CI 0.50 to 1.17). Subgroup

First Results from The GlueX Experiment

Energy Technology Data Exchange (ETDEWEB)

Meyer, Curtis [Carnegie Mellon Univ., Pittsburgh, PA (United States)

2016-05-01

The GlueX experiment at Jefferson Lab ran with its first commissioning beam in late 2014 and the spring of 2015. Data were collected on both plastic and liquid hydrogen targets, and much of the detector has been commissioned. All of the detector systems are now performing at or near design specifications and events are being fully reconstructed, including exclusive production of pi^0, eta and omega mesons. Linearly-polarized photons were successfully produced through coherent bremsstrahlung and polarization transfer to the ρ has been observed.

Effect of Wheat Straw Pretreatments and Glue Formulations on particle board properties

International Nuclear Information System (INIS)

Jabeen, S.; Naveed, S.; Yousaf, S.; Ramzan, N.

2014-01-01

In this paper, the effect of wheat straw (WS) pretreatments and glue formulations on mechanical (i.e. Compressive Strength (CS) and Impact Strength (IS)) and water resistance properties (i.e. Thickness Swelling (TS) and water absorption (WA)) of particle board have been investigated and the results have been compared with conventional wooden particleboard. Wheat straw was treated with steam available at 110 degree C and 20 psig, for the retention time of 5, 10 and 15 min. The solution of 10% HCl was also used for removing the lignin. Particleboard was prepared by bonding treated WS with four types of glue recipes of synthetic and natural binders like urea formaldehyde (UF), polyvinyl acetate (PVA), corn flour (CF) and wheat flour (WF). The particle board was formed at the hydraulic pressure and temperature of 2800 psig and 80 degree C respectively. It was observed that WS particleboard has low mechanical strength and high water resistance in comparison with conventional board. The particle board prepared with HCl cured wheat straw and glue having high urea formaldehyde and corn flour has higher CS and IS as well as low TS and WA. It may be concluded that wheat straw is a good substitute of wood for particle board while using HCl as a modifying chemical and strong binders like urea formaldehyde and corn flour. (author)

Contribution of glue layer into epidermis sample fluorescence dynamics

Science.gov (United States)

Salomatina, Elena V.; Chernova, Svetlana P.; Pravdin, Alexander B.

2000-04-01

In this work, the temporal behavior of autofluorescence of epidermis samples under UV-irradiation has ben studied. The samples were prepared using surface epidermis stripping technique. Fluorescence spectra and kinetic curves of fluorescence intensity have been obtained. It has been concluded that the glue composition used allows the measurement of epidermis fluorescence dynamics with the first 60 min of experiment.

Informal uncertainty analysis (GLUE) of continuous flow simulation in a hybrid sewer system with infiltration inflow - Consistency of containment ratios in calibration and validation?

DEFF Research Database (Denmark)

Breinholt, Anders; Grum, Morten; Madsen, Henrik

2013-01-01

to assess parameter and flow simulation uncertainty using a simplified lumped sewer model that accounts for three separate flow contributions: wastewater, fast runoff from paved areas, and slow infiltrating water from permeable areas. Recently GLUE methodology has been critisised for generating prediction...... rain inputs and more accurate flow observations to reduce parameter and model simulation uncertainty. © Author(s) 2013....

Clinical and morphological evaluation of snake venom derived fibrin glue on the tendon healing in dogs

Directory of Open Access Journals (Sweden)

G. C. Ferraro

2005-12-01

Full Text Available The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the healing of the deep digital flexor tendon, during three periods. The tendon of the 2nd digit of 30 thoracic limbs of dogs was partially sectioned for glue application. Biopsies were performed 7, 15, and 30 days post surgery for the clinical and morphological study of tendons. Analysis of the results showed that 73.3% of the tendons showed stump retraction and 16.6% moderate to excessive adherence, which affected sliding. There was a significant difference in the number of inflammatory cells among the three studied periods, being the highest on day 15. The morphological analysis revealed a typical tendon healing process with a lower level of inflammation in the acute phase, facilitating the cicatricial maturation phase. Snake venom derived fibrin glue promotes the healing in dog flexor tendon.

Development of Silicon Photomultipliers and their Applications to GlueX Calorimetry

Energy Technology Data Exchange (ETDEWEB)

Smith, Elton S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

2016-07-01

The GlueX experiment is a photoproduction experiment in Hall D at Jefferson Lab that is being commissioned for use with the new 12 GeV accelerator. The purpose of the experiment is to search for Hybrid mesons, which are mesons with quark and gluon degrees of freedom. The barrel calorimeter of GlueX is instrumented with 4000 large-area (1.2 x1.2 cm2) silicon photomultipliers (SiPMs). These photon sensors have properties similar to vacuum photomultipliers, but are unaffected by high magnetic fields. In our experiment they operate in magnetic fields exceeding 1T. After extensive tests with a variety of sensors, we chose the S12045(X) custom SiPM arrays manufactured by Hamamatsu Corporation, also known as multi-pixel photon counters (MPPCs). We will give an overview of this new technology as well as the experience gained during two commissioning periods with beam.

Development of silicon photomultipliers and their applications to GlueX calorimetry

Energy Technology Data Exchange (ETDEWEB)

Smith, Elton S., E-mail: elton@jlab.org [Jefferson Lab, Newport News, VA 23606 (United States)

2016-07-07

The GlueX experiment is a photoproduction experiment in Hall D at Jefferson Lab that is being commissioned for use with the new 12 GeV accelerator. The purpose of the experiment is to search for Hybrid mesons, which are mesons with quark and gluon degrees of freedom. The barrel calorimeter of GlueX is instrumented with 4000 large-area (1.2 × 1.2 cm{sup 2}) silicon photomultipliers (SiPMs). These photon sensors have properties similar to vacuum photomultipliers, but are unaffected by high magnetic fields. In our experiment they operate in magnetic fields exceeding 1T. After extensive tests with a variety of sensors, we chose the S12045(X) custom SiPM arrays manufactured by Hamamatsu Corporation, also known as multi-pixel photon counters (MPPCs). We will give an overview of this new technology as well as the experience gained during two commissioning periods with beam.

A planning and analysis framework for evaluating distributed generation and utility strategies

International Nuclear Information System (INIS)

Ault, Graham W.

2000-01-01

The numbers of smaller scale distributed power generation units connected to the distribution networks of electricity utilities in the UK and elsewhere have grown significantly in recent years. Numerous economic and political drivers have stimulated this growth and continue to provide the environment for future growth in distributed generation. The simple fact that distributed generation is independent from the distribution utility complicates planning and operational tasks for the distribution network. The uncertainty relating to the number, location and type of distributed generating units to connect to the distribution network in the future makes distribution planning a particularly difficult activity. This thesis concerns the problem of distribution network and business planning in the era of distributed generation. A distributed generation strategic analysis framework is proposed to provide the required analytical capability and planning and decision making framework to enable distribution utilities to deal effectively with the challenges and opportunities presented to them by distributed generation. The distributed generation strategic analysis framework is based on the best features of modern planning and decision making methodologies and facilitates scenario based analysis across many utility strategic options and uncertainties. Case studies are presented and assessed to clearly illustrate the potential benefits of such an approach to distributed generation planning in the UK electricity supply industry. (author)

Generalized likelihood uncertainty estimation (GLUE) using adaptive Markov chain Monte Carlo sampling

DEFF Research Database (Denmark)

Blasone, Roberta-Serena; Vrugt, Jasper A.; Madsen, Henrik

2008-01-01

propose an alternative strategy to determine the value of the cutoff threshold based on the appropriate coverage of the resulting uncertainty bounds. We demonstrate the superiority of this revised GLUE method with three different conceptual watershed models of increasing complexity, using both synthetic......In the last few decades hydrologists have made tremendous progress in using dynamic simulation models for the analysis and understanding of hydrologic systems. However, predictions with these models are often deterministic and as such they focus on the most probable forecast, without an explicit...... of applications. However, the MC based sampling strategy of the prior parameter space typically utilized in GLUE is not particularly efficient in finding behavioral simulations. This becomes especially problematic for high-dimensional parameter estimation problems, and in the case of complex simulation models...

Use of fibrin glue in the management of recurrent pterygium by conjunctival autograft

International Nuclear Information System (INIS)

Virendra K. Malik; Sandeep Kumar

2010-01-01

To evaluate whether use of fibrin glue instead of sutures for the treatment of recurrent pterygium with conjunctival auto-graft (CAG) further decreases its recurrence. A prospective, clinical open trial of 50 eyes of 50 patients with recurrent pterygium, who were randomly assigned to either, pterygium excision and CAG with fibrin glue (Group 1) or with 6 interrupted sutures (Group 2), was carried out from January 2009 to July 2010 at the outpatient department of Subharti Medical College, Meerut, North India. Both groups had 25 patients each. The groups were compared with regards to the surgical time taken, development of recurrence, postoperative symptoms (irritation, watering, and redness), and complications. Recurrence was seen in one (4%) eye in group I, and 3 (12%) eyes in group II after 9-13 months of follow up. The difference between the 2 groups was not statistically significant. The surgical time was significantly reduced, and postoperative inflammation and complications were less in group I. Postoperative symptoms were significantly more in group II patients. While conjunctival autograft with sutures for management of recurrent pterygium appears to be a safe and feasible modality, fibrin glue fixation of the autograft is a more viable option in terms of surgical ease, less time consuming, less postoperative complications, and less recurrence (Author).

A general contact mechanical formulation of multilayered structures and its application to deconvolute thickness/mechanical properties of glue used in surface force apparatus.

Science.gov (United States)

Math, Souvik; Horn, Roger; Jayaram, Vikram; Biswas, Sanjay Kumar

2007-04-15

Currently data obtained from surface force apparatus experiments are convoluted with the mechanical response of glue of unknown thickness, used to bond mica sheets to the substrates. This paper describes a formulation to precisely deconvolute out the forces between the mica sheets by determining the thickness of glue, knowing the mechanical properties of the glue. The formulation consists of a general solution based on the noniterative Hankel transform of the Laplace equation. The generality is achieved by treating all the layers except the one in contact as an effective lumped system consisting of a set of springs in series, where each spring represents a layer. The solution is validated by nanoindentation of trilayer systems consisting of layers with widely diverse mechanical properties, some differing from each other by three orders of magnitude. SFA experiments are done with carefully metered slabs of glue. The proposed method is validated by comparing the actual glue thicknesses with those determined using the present analysis.

Application of fibrin glue with bandage contact lens in pterygium surgery

Directory of Open Access Journals (Sweden)

Wei Liu

2014-05-01

Full Text Available AIM: To explore the efficacy of fibrin glue with bandage contact lens for pain relief after pterygium surgery performed with limbal autograft transplantation.METHODS: A prospective clinical trial was carried out in 52 patients(72 eyesoperated for primary nasal pterygium. All patients were randomly divided into the fibrin glue with bandage contact lens group(experimental group, 28 cases, 38 eyesand suture group(control group, 24 cases, 34 eyes. Autologous limbal graft taken from the superotemporal limbus was used to cover the sclera after pterygium excision under local anesthesia with 20g/L lidocaine. In experimental group, the transplant was attached to the sclera with fibrin tissue adhesive and in control group with 10-0 Virgin silk sutures. Experimental group weared bandage contact lens after surgery while the control group did not. The degree of pain after surgery was evaluated at 1, 2, 3, 5 and 7d after surgery. Follow-up was 6mo, matching degree of graft and complication such as infection, relapse, implant healing badness and subconjunctival cyst were mainly observed and recorded.RESULTS: The pain index scores of the experimental group were significantly less than those of control group(all P=0.000. In observation period, all conjunctival autografts in both groups were successfully attached and were intact without falling off, dissolution or recurrence and there were no complications such as infection, relapse, implant healing badness and subconjunctival cyst.CONCLUSION: Fibrin glue with bandage contact lens could significantly release pain response afterpterygium excision surgery.

Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS Inner Detector

CERN Document Server

INSPIRE-00407830; Bloch, Ingo; Edwards, Sam; Friedrich, Conrad; Gregor, Ingrid M.; Jones, T; Lacker, Heiko; Pyatt, Simon; Rehnisch, Laura; Sperlich, Dennis; Wilson, John

2016-05-24

The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). This glue has several disadvantages, which motivated the search for an alternative. This paper presents a study concerning the use of six ultra-violet (UV) cure glues and a glue pad for use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, the thermal conduction and shear strength, thermal cycling, radiation hardness, corrosion resistance and shear strength tests. These investigatio...

Re: Fibrin Glue Injections: A Minimally Invasive and Cost-Effective Treatment for Post-Renal Transplant Lymphoceles and Lymph Fistulas

Directory of Open Access Journals (Sweden)

Presser N

2016-03-01

Full Text Available In this retrospective study, 46 (2.7% patients out of 1662 kidney transplant recipients had developed symptomatic lymphocele/lymph fistula requiring intervention over an 11-year period. Open surgical drainage (22, laparoscopic surgical drainage (11 and percutaneous fibrin glue injections into the drained lymphocele cavity (13 were used to treat this complication. Besides being effective both on the early and late developed lymphoceles, significantly lower recurrence rates by fibrin glue injections and lower median treatment costs were observed when compared with the other two surgical modalities. It has also the advantage of an outpatient procedure that can be performed using fluoroscopic guidance, under local anesthesia. However, due to era effect, most of the open and laparoscopic surgical recipients were treated with sirolimus, a well-known antiproliferative immunosuppressive agent, which can promote development of lymphoceles and surgical failure. However, the majority of fibrin glue-treated cases were with tacrolimus-based regimens, but this study, in its nature, is far from giving the answer for decreased number of recurrences with fibrin glue

Percutaneous Glue Embolization of a Visceral Artery Pseudoaneurysm in a Case of Sickle Cell Anemia

International Nuclear Information System (INIS)

Gulati, Gurpreet S.; Gulati, Manpreet S.; Makharia, Govind; Hatimota, Pradeep; Saikia, Nripen; Paul, Shashi B.; Acharya, Subrat

2006-01-01

Although aneurysmal complications of sickle cell anemia have been described in the intracranial circulation, visceral artery pseudoaneurysms in this disease entity have not previously been reported in the literature. Conventional treatment of visceral pseudoaneurysms has been surgical ligation or resection of the aneurysm. Transcatheter embolization has emerged as an attractive, minimally invasive alternative to surgery in the treatment of these lesions. In certain situations, however, due to the unfavorable angiographic anatomy precluding safe transcatheter embolization, direct percutaneous glue injection of the pseudoaneurysm sac may be considered to achieve successful occlusion of the sac. The procedure may be rendered safer by simultaneous balloon protection of the parent artery. We describe this novel treatment modality in a case of inferior pancreaticoduodenal artery pseudoaneurysm in a patient with sickle cell anemia. Although a complication in the form of glue reflux into the parent vessel occurred that necessitated surgery, this treatment modality may be used in very selected cases (where conventional endovascular embolization techniques are not applicable) after careful selection of the balloon diameter and appropriate concentration of the glue-lipiodol mixture

Framework for Enabling User-Generated Content

OpenAIRE

Nilsson, Karin H

2012-01-01

User-generated content, UGC, is a modern topic today and refers to media and creative works created by Internet users and posted on the Internet. More and more application developers wants to offer sharing functionalities in their applications and on their websites. The alternatives of doing so today are to use UGC platforms API, like Facebook and Twitter, to upload the content to that specific platform or to implement the framework ShareKit that enables the user to share their content on mul...

Versatile fabrication of paper-based microfluidic devices with high chemical resistance using scholar glue and magnetic masks.

Science.gov (United States)

Cardoso, Thiago M G; de Souza, Fabrício R; Garcia, Paulo T; Rabelo, Denilson; Henry, Charles S; Coltro, Wendell K T

2017-06-29

Simple methods have been developed for fabricating microfluidic paper-based analytical devices (μPADs) but few of these devices can be used with organic solvents and/or aqueous solutions containing surfactants. This study describes a simple fabrication strategy for μPADs that uses readily available scholar glue to create the hydrophobic flow barriers that are resistant to surfactants and organic solvents. Microfluidic structures were defined by magnetic masks designed with either neodymium magnets or magnetic sheets to define the patter, and structures were created by spraying an aqueous solution of glue on the paper surface. The glue-coated paper was then exposed to UV/Vis light for cross-linking to maximize chemical resistance. Examples of microzone arrays and microfluidic devices are demonstrated. μPADs fabricated with scholar glue retained their barriers when used with surfactants, organic solvents, and strong/weak acids and bases unlike common wax-printed barriers. Paper microzones and microfluidic devices were successfully used for colorimetric assays of clinically relevant analytes commonly detected in urinalysis to demonstrate the low background of the barrier material and generally applicability to sensing. The proposed fabrication method is attractive for both its ability to be used with diverse chemistries and the low cost and simplicity of the materials and process. Copyright © 2017 Elsevier B.V. All rights reserved.

An object-oriented framework for the hadronic Monte-Carlo event generators

International Nuclear Information System (INIS)

Amelin, N.; Komogorov, M.

1999-01-01

We advocate the development of an object-oriented framework for the hadronic Monte-Carlo (MC) event generators. The hadronic MC user and developer requirements are discussed as well as the hadronic model commonalities. It is argued that the development of a framework is in favour of taking into account of model commonalities since common means are stable and can be developed only at once. Such framework can provide different possibilities to have user session more convenient and productive, e.g., an easy access and edition of any model parameter, substitution of the model components by the alternative model components without changing the code, customized output, which offers either full information about history of generated event or specific information about reaction final state, etc. Such framework can indeed increase the productivity of a hadronic model developer, particularly, due to the formalization of the hadronic model component structure and model component collaborations. The framework based on the component approach opens a way to organize a library of the hadronic model components, which can be considered as the pool of hadronic model building blocks. Basic features, code structure and working examples of the first framework version for the hadronic MC models, which has been built as the starting point, are shortly explained

Preliminary report of a sutureless onlay technique for incisional hernia repair using fibrin glue alone for mesh fixation.

Science.gov (United States)

Stoikes, Nathaniel; Webb, David; Powell, Ben; Voeller, Guy

2013-11-01

The Rives repair for ventral/incisional (V/I) hernias involves sublay mesh placement requiring retrorectus dissection and transfascial stitches. Chevrel described a repair by onlaying mesh after a unique primary fascial closure. Although Chevrel fixated mesh to the anterior fascia with sutures, he used fibrin glue for fascial closure reinforcement. We describe an onlay technique with mesh fixated to the anterior fascia solely with fibrin glue without suture fixation. From January 2010 to January 2012, 50 patients underwent a V/I hernia onlay technique with fibrin glue mesh fixation. Records were reviewed for technical details, demographics, mesh characteristics, and postoperative outcomes. Primary fascial closure with interrupted permanent suture was done with or without myofascial advancement flaps. Onlay polypropylene mesh was placed providing 8 cm of overlap. Fibrin glue was applied over the prosthesis and subcutaneous drains were placed. Mean age was 62.4 years. Mean body mass index was 30.1 kg/m(2). Average mesh size was 14.5 cm × 19.1 cm. Mean operative time was 144.4 minutes (range, 38 to 316 minutes). Mean discharge was postoperative Day 2.9 (range, 0 to 15 days). Morbidity included eight seromas, one hematoma, and three wound infections. Seventeen patients required components separation. Mean follow-up was 19.5 months with no recurrences. This is the first series describing fibrin glue alone for mesh fixation for V/I hernia repair. It allows for immediate prosthesis fixation to the anterior fascia. Early results are promising. Potential advantages include less operative time, less technical difficulty, and less long-term pain. A prospective trial is needed to evaluate this approach.

Coronary artery narrowing after aortic root reconstruction with resorcin-formalin glue.

Science.gov (United States)

Martinelli, L; Graffigna, A; Guarnerio, M; Bonmassari, R; Disertori, M

2000-11-01

Severe stenosis of right and left main coronary artery ostia developed after aortic root reconstruction with gelatin-resorcin-formol glue for correction of acute type A aortic dissection. Surgical treatment of this condition required grafting of the right and left anterior descending arteries with bilateral mammary arteries on the beating heart.

The impact and adoption of GLUE 2.0 in the LCG/EGEE production Grid

International Nuclear Information System (INIS)

Burke, Stephen; Andreozzi, Sergio; Donno, Flavia; Ehm, Felix; Field, Laurence; Litmaath, Maarten; Millar, Paul

2010-01-01

The GLUE information schema has been in use in the LCG/EGEE production Grid since the first version was defined in 2002. In 2007 a major redesign of GLUE, version 2.0, was started in the context of the Open Grid Forum following the creation of the GLUE Working Group. This process has taken input from a number of Grid projects, but as a major user of the version 1 schema LCG/EGEE has had a strong interest that the new schema should support its needs. In this paper we discuss the structure of the new schema in the light of the LCG/EGEE requirements and explain how they are met, and where improvements have been achieved compared with the version 1 schema. In particular we consider some difficulties encountered in recent extensions of the use of the version 1 schema to aid resource accounting in LCG, to enable the use of the SRM version 2 storage protocol by the LHC experiments, and to publish information about a wider range of services to improve service discovery. We describe how these can be better met by the new schema, and we also discuss the way in which the transition to the new schema is being managed.

Comparison of mechanical compressive properties of commercial and autologous fibrin glues for tissue engineering applications.

Science.gov (United States)

Cravens, Matthew G; Behn, Anthony W; Dragoo, Jason L

2017-11-01

Fibrin glues are widely used in orthopedic surgery as adhesives and hemostatic agents. We evaluated the compressive properties of selected fibrin glues in order to identify which are appropriate for tissue regeneration applications subject to compression. Uniaxial unconfined compression tests were performed on fibrin gels prepared from commercial and autologous products: (1) Evicel (Ethicon), (2) Tisseel (Baxter), (3) Angel (Arthrex), and (4) ProPlaz (Biorich). Cyclic loads were applied from 0 to 30% strain for 100cycles at 0.5Hz. Following cyclic testing, specimens were subjected to ramp displacement of 1% strain per second to 80% strain. Throughout cyclic loading, Evicel and Tisseel deformed (shortened) less than Angel at all but one time point, and deformed less than ProPlaz at cycles 10 and 20. The dynamic moduli, peak stress, and strain energy were significantly greater in Tisseel than all other groups. Evicel displayed significantly greater dynamic moduli, peak stress, and strain energy than Angel and ProPlaz. Following cyclic testing, Tisseel and Evicel were significantly less deformed than Angel. No specimens exhibited gross failure during ramp loading to 80% strain. Ramp loading trends mirrored those of cyclic loading. The tested commercial glues were significantly more resistant to compression than the autologous products. The compressive properties of Tisseel were approximately twice those of Evicel. All preparations displayed moduli multiple orders of magnitude less than that of native articular cartilage. We conclude that in knee surgeries requiring fibrin glue to undergo compression of daily activity, commercial products are preferable to autologous preparations from platelet-poor plasma, though both will deform significantly. Copyright © 2017 Elsevier Ltd. All rights reserved.

Endoluminal embolization of bilateral atherosclerotic common iliac aneurysms with fibrin tissue glue (Beriplast)

International Nuclear Information System (INIS)

Beese, Richard C.; Tomlinson, Mark A.; Buckenham, Timothy M.

2000-01-01

The standard surgical approach to nonleaking iliac aneurysms found at repair of a leaking abdominal aortic aneurysm is to minimize the operative risk by repairing the abdominal aorta only. This means that the bypassed iliac aneurysms may have to be repaired later. As this population of patients are usually elderly with coexisting medical problems, interventional radiology is being used to embolize these aneurysms, thus avoiding the morbidity and mortality associated with further general anesthesia and surgery. Various materials and stents have been reported to be effective in the treatment of iliac aneurysms. We report the successful use of endoluminal fibrin tissue glue (Beriplast) to treat two large iliac aneurysms in a patient who had had a previous abdominal aortic aneurysm repair. We discuss the technique involved and the reasons why we used tissue glue in this patient.

A Framework for the Next Generation of Risk Science

Science.gov (United States)

Krewski, Daniel; Andersen, Melvin E.; Paoli, Gregory M.; Chiu, Weihsueh A.; Al-Zoughool, Mustafa; Croteau, Maxine C.; Burgoon, Lyle D.; Cote, Ila

2014-01-01

Objectives: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. Methods: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making. Results: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making. Conclusions: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice. Citation: Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I. 2014. A framework for the next generation of risk science. Environ Health Perspect 122:796–805; http://dx.doi.org/10.1289/ehp.1307260 PMID:24727499

Humidity control and hydrophilic glue coating applied to mounted protein crystals improves X-ray diffraction experiments

International Nuclear Information System (INIS)

Baba, Seiki; Hoshino, Takeshi; Ito, Len; Kumasaka, Takashi

2013-01-01

A new crystal-mounting method has been developed that involves a combination of controlled humid air and polymer glue for crystal coating. This method is particularly useful when applied to fragile protein crystals that are known to be sensitive to subtle changes in their physicochemical environment. Protein crystals are fragile, and it is sometimes difficult to find conditions suitable for handling and cryocooling the crystals before conducting X-ray diffraction experiments. To overcome this issue, a protein crystal-mounting method has been developed that involves a water-soluble polymer and controlled humid air that can adjust the moisture content of a mounted crystal. By coating crystals with polymer glue and exposing them to controlled humid air, the crystals were stable at room temperature and were cryocooled under optimized humidity. Moreover, the glue-coated crystals reproducibly showed gradual transformations of their lattice constants in response to a change in humidity; thus, using this method, a series of isomorphous crystals can be prepared. This technique is valuable when working on fragile protein crystals, including membrane proteins, and will also be useful for multi-crystal data collection

Humidity control and hydrophilic glue coating applied to mounted protein crystals improves X-ray diffraction experiments

Energy Technology Data Exchange (ETDEWEB)

Baba, Seiki; Hoshino, Takeshi; Ito, Len; Kumasaka, Takashi, E-mail: kumasaka@spring8.or.jp [Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 1-1-1 Kouto, Sayo, Hyogo 679-5198 (Japan)

2013-09-01

A new crystal-mounting method has been developed that involves a combination of controlled humid air and polymer glue for crystal coating. This method is particularly useful when applied to fragile protein crystals that are known to be sensitive to subtle changes in their physicochemical environment. Protein crystals are fragile, and it is sometimes difficult to find conditions suitable for handling and cryocooling the crystals before conducting X-ray diffraction experiments. To overcome this issue, a protein crystal-mounting method has been developed that involves a water-soluble polymer and controlled humid air that can adjust the moisture content of a mounted crystal. By coating crystals with polymer glue and exposing them to controlled humid air, the crystals were stable at room temperature and were cryocooled under optimized humidity. Moreover, the glue-coated crystals reproducibly showed gradual transformations of their lattice constants in response to a change in humidity; thus, using this method, a series of isomorphous crystals can be prepared. This technique is valuable when working on fragile protein crystals, including membrane proteins, and will also be useful for multi-crystal data collection.

GLUE Based Uncertainty Estimation of Urban Drainage Modeling Using Weather Radar Precipitation Estimates

DEFF Research Database (Denmark)

Nielsen, Jesper Ellerbæk; Thorndahl, Søren Liedtke; Rasmussen, Michael R.

2011-01-01

Distributed weather radar precipitation measurements are used as rainfall input for an urban drainage model, to simulate the runoff from a small catchment of Denmark. It is demonstrated how the Generalized Likelihood Uncertainty Estimation (GLUE) methodology can be implemented and used to estimate...

First e⁻/γ Commissioning Results for the GlueX Experiment/Hall D at CEBAF

Energy Technology Data Exchange (ETDEWEB)

McCaughan, Michael D. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Satogata, Todd J. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Roblin, Yves R. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Benesch, Jay F. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

2015-09-01

Experimental Hall D, with flagship experiment GlueX, was constructed as part of the 12 GeV CEBAF upgrade. A new magnetically extracted electron beam line was installed to support this hall. Bremsstrahlung photons from retractable radiators are delivered to the experiment through a series of collimators following a long drift to allow for beam convergence. Coherent Bremsstrahlung generated by interaction with a diamond radiator will achieve a nominal 40% linear polarization and photon energies between 8.5 and 9 GeV from 12.1 GeV electrons, which are then tagged or diverted to a medium power 60kW electron dump. The expected photon flux is 10⁷-10⁸ Hz. This paper discusses the experimental line design, commissioning experience gained since first beam in spring 2014, and the present results of beam commissioning by the experiment.

Determining the hydraulic and fracture properties of the Coal Seam Gas well by numerical modelling and GLUE analysis

Science.gov (United States)

Askarimarnani, Sara; Willgoose, Garry; Fityus, Stephen

2017-04-01

Coal seam gas (CSG) is a form of natural gas that occurs in some coal seams. Coal seams have natural fractures with dual-porosity systems and low permeability. In the CSG industry, hydraulic fracturing is applied to increase the permeability and extract the gas more efficiently from the coal seam. The industry claims that it can design fracking patterns. Whether this is true or not, the public (and regulators) requires assurance that once a well has been fracked that the fracking has occurred according to plan and that the fracked well is safe. Thus defensible post-fracking testing methodologies for gas generating wells are required. In 2009 a fracked well HB02, owned by AGL, near Broke, NSW, Australia was subjected to "traditional" water pump-testing as part of this assurance process. Interpretation with well Type Curves and simple single phase (i.e. only water, no gas) highlighted deficiencies in traditional water well approaches with a systemic deviation from the qualitative characteristic of well drawdown curves (e.g. concavity versus convexity of drawdown with time). Accordingly a multiphase (i.e. water and methane) model of the well was developed and compared with the observed data. This paper will discuss the results of this multiphase testing using the TOUGH2 model and its EOS7C constitutive model. A key objective was to test a methodology, based on GLUE monte-carlo calibration technique, to calibrate the characteristics of the frack using the well test drawdown curve. GLUE involves a sensitivity analysis of how changes in the fracture properties change the well hydraulics through and analysis of the drawdown curve and changes in the cone of depression. This was undertaken by changing the native coal, fracture, and gas parameters to see how changing those parameters changed the match between simulations and the observed well drawdown. Results from the GLUE analysis show how much information is contained in the well drawdown curve for estimating field scale

Improved distal distribution of n-butyl cyanoacrylate glue by simultaneous injection of dextrose 5% through the guiding catheter: technical note

International Nuclear Information System (INIS)

Moore, Carolyn; Murphy, Kieran; Gailloud, Philippe

2006-01-01

The use of n-butyl cyanoacrylate (NBCA) as an adhesive agent for embolization of high-flow intracranial and extracranial vascular lesions is well established. To be successful, the embolization of arteriovenous malformations and fistulas must achieve obliteration of the arteriovenous shunts themselves rather than simply occlude the feeders proximal to the lesion. However, the feeders cannot always be negotiated over their entire length. This is often the case with dural arteriovenous fistulas (DAVF), which are usually vascularized by long and intricate meningeal networks. In such situations, NBCA may not be able to reach the lesion itself, rendering the embolization ineffective. We present a new technique that improves distal distribution of NBCA glue. The technique described in this report consists of injecting dextrose 5% through the guiding catheter simultaneously with the superselective injection of NBCA glue into the targeted feeding branch. The technique is illustrated with three cases of posterior fossa DAVF. In the reported cases, flooding the territory of the targeted vessel with non-ionic dextrose 5% allowed deep progression of the glue by delaying contact with ionic substances. Excellent distribution of the NBCA glue reaching the site of the arteriovenous shunts was thus obtained despite suboptimal proximal microcatheter tip positions. (orig.)

Management of an extrasphincteric fistula in an HIV-positive patient by using fibrin glue: a case report with tips and tricks

Directory of Open Access Journals (Sweden)

Sapalidis Konstantinos

2010-02-01

Full Text Available Abstract Background Individuals with impaired immunity are at higher risk of perianal diseases. Concerning complex anal fistulas impaired healing and complication rates are also higher. Definitive treatment of a fistula aims controlling the purulent discharge and prevents its recurrence. It depends mainly on the trajectory of the fistula and the underlying disease. We present a case of a HIV-positive patient with a complex extrasphincteric anal fistula who was treated successfully with fibrin glue application. We further, discuss tips and tricks when applying fibrin glue as plugging material in complex anal fistulas. Case presentation A sixty-one-year-old HIV-positive male referred to us for warts and extrasphincteric fistula. Because of the patients' immunological status, we opted against surgery and recommended fibrin glue plugging. The patient was discharged the same day. A follow-up examination was performed 5 days after the initial fibrin glue application showing that the fistula canal was obstructed. Three months and a year post-intervention the fistula tract remains closed. Conclusion The best treatment for a disease gives at least the same result with the other treatments with minimised risk for the life of the patient and minimal application effort. Conservative closure of fistula with fibrin plugging is simple, safe and with less morbidity than surgery. Our patient was successfully treated without endangering his life despite his precarious medical state. Not everybody believes in the effectiveness of fibrin glue application, however we consider this solution in cases of complex fistulas at least as primary procedure in special populations such as the immunosupressed.

[The advantages in using cyanoacrylate glue over skin staples as a method of skin graft fixation in the pediatric burns population].

Science.gov (United States)

Curings, P; Vincent, P-L; Viard, R; Gir, P; Comparin, J-P; Voulliaume, D

2017-11-23

Local postoperative care and burn wound management can present with a certain degree of difficulty in the pediatric population. While the use of skin staples as a method of skin graft fixation is a well-known, rapid and simple method, their removal can be painful and may necessitate some sedation or even general anesthesia. We studied in this article the advantages and economic value of using the cyanoacrylate glue as a fixation method for skin grafts. A comparative study was carried out from 2012 to 2016. Hundred and eighteen infants with burns up to 5% of total body surface area were included in the study. Seventy-two infants had split thickness skin grafts fixed with skin staples. Forty-six infants had split thickness skin grafts fixed with cyanoacrylate glue. We compared the quality of graft, the sedation used during the first postoperative dressing, the length of hospital stay, the amount of glue used and the presence of complications. There is a difference between the two groups studied in terms of age and total burn surface area. The rate of graft take was 100% in both groups. The first postoperative dressing was carried out without the use of powerful analgesia in the cyanoacrylate group, while it was necessary to use general anesthesia in 64% of the skin staples group. The average length of stay in hospital after skin grafting was 4.9 days for the cyanoacrylate glue versus 6.5 days in the skin staples group. No complications were noted in the 2 groups. The use of cyanoacrylate glue allows rapid fixation of skin grafts and avoid general anesthesia for postoperative cares. Subsequently the length of hospital stay is reduced within 25%. The medico-economic value of glue protocol is highly significant compared to skin staples, while having similar good results and without significant problems. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Extending the Framework of Generativity Theory Through Research: A Qualitative Study.

Science.gov (United States)

Rubinstein, Robert L; Girling, Laura M; de Medeiros, Kate; Brazda, Michael; Hannum, Susan

2015-08-01

Based on ethnographic interviews, we discuss three ideas we believe will expand knowledge of older informants' thoughts about and representations of generativity. We adapt the notion of "dividuality" as developed in cultural anthropology to reframe ideas on generativity. The term dividuality refers to a condition of interpersonal or intergenerational connectedness, as distinct from individuality. We also extend previous definitions of generativity by identifying both objects of generative action and temporal and relational frameworks for generative action. We define 4 foci of generativity (people, groups, things, and activities) and 4 spheres of generativity (historical, familial, individual, and relational) based in American culture and with which older informants could easily identify. The approach outlined here also discusses a form of generativity oriented to the past in which relationships with persons in senior generations form a kind of generative action since they are involved in caring for the origins of the self and hence of future generative acts. These 3 elements of a new framework will allow researchers to pose critical questions about generativity among older adults. Such questions include (a) How is the self, as culturally constituted, involved in generative action? and (b) What are the types of generativity within the context of American culture and how are they spoken about? Each of the above points is directly addressed in the data we present below. We defined these domains through extended ethnographic interviews with 200 older women. The article addresses some new ways of thinking about generativity as a construct, which may be useful in understanding the cultural personhood of older Americans. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Management of nontraumatic corneal perforation with tectonic drape patch and cyanoacrylate glue.

Science.gov (United States)

Khalifa, Yousuf M; Bailony, M Rami; Bloomer, Michele M; Killingsworth, Daniel; Jeng, Bennie H

2010-10-01

To report a case of nontraumatic corneal perforation managed with a tectonic drape patch. Interventional case report. A 60-year-old patient with a corneal scar in his left eye likely secondary to herpes simplex virus interstitial keratitis underwent laser peripheral iridotomy for narrow angles. He developed progressive thinning of the cornea overlying the scar that led to a descemetocele and then ultimately a 1.2- × 1.7-mm perforation. Intraoperatively, several attempts were made to seal the perforation with cyanoacrylate glue, but the wound continued to leak. Sterile plastic drape that was on the surgical field was fashioned into a 2-mm-diameter patch, and the peripheral edge of the tectonic drape patch was glued over the perforation, successfully sealing the cornea. One week later, the drape patch was intact without leak, and a penetrating keratoplasty was carried out without complication. Tectonic drape patch technique for nontraumatic corneal perforations in which there is tissue loss is a viable temporizing option when cyanoacrylate glue alone fails and when there is no corneal tissue or amniotic membrane available to close the wound.

Percutaneous sclerotherapy of sialoceles after parotidectomy with fibrin glue, OK-432, and bleomycin.

Science.gov (United States)

Chen, Wei-liang; Zhang, Li-ping; Huang, Zhi-quan; Zhou, Bin

2013-12-01

We evaluated the curative effect of fibrin glue combined with OK-432 (streptococcal pyrogenic exotoxin A, Picibanil™) and bleomycin on 9 patients with sialoceles after parotidectomy. The primary lesions included pleomorphic adenomas in 6 cases and Warthin's tumours in 3 cases. After a sialocele had been diagnosed each patient had repeated aspirations and pressure dressings for 3-4 weeks, but these treatments failed. The patients were then treated with percutaneous sclerotherapy with the injection of fibrin glue 8-10 ml combined with OK-432 5 mg and bleomycin 15 mg. All the sialoceles disappeared completely after a single procedure in 2-3 weeks. The patients have been followed up for more than 6 months with no evidence of recurrent sialocele or injury to the facial nerve related to sclerotherapy. This simple, safe technique can be successfully used to treat sialoceles after parotidectomy. Copyright © 2013 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Intraoperative use of fibrin glue dyed with methylene blue in surgery for branchial cleft anomalies.

Science.gov (United States)

Piccioni, Michela; Bottazzoli, Marco; Nassif, Nader; Stefini, Stefania; Nicolai, Piero

2016-09-01

We present a new method of optimizing the results of surgery for branchial cleft anomalies based on the intraoperative injection of fibrin glue combined with methylene blue dye. Retrospective single-center cohort study. The method was applied in 17 patients suffering from branchial anomalies. Six (35.29%) had a preauricular lesion; three (17.65%) had lesions derived from the first arch/pouch/groove (type I), four (23.53%) had lesions derived from the first (type II), one (5.88%) had lesions derived from the second, one (5.88%) had lesions derived from the third, and two (11.76%) had lesions derived from the fourth. The median and mean age at surgery were 10 and 10.6 years, respectively. All patients were followed by periodic clinical and ultrasonographic examination. The combination of fibrin glue with methylene blue facilitated the correct assessment of the extension of the lesions and their intraoperative manipulation. After a mean follow-up of 47.8 months, all patients were free of disease. Intraoperative injection of branchial fistulae and cysts by a mixture of fibrin glue and methylene blue is an effective, easy, and safe tool to track lesions and achieve radical resection. The technique requires a definitive validation on a large cohort with adequate stratification of patients. 4 Laryngoscope, 126:2147-2150, 2016. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

The GlueX central drift chamber: Design and performance

International Nuclear Information System (INIS)

Van Haarlem, Y.; Meyer, C.A.; Barbosa, F.; Dey, B.; Lawrence, D.; Razmyslovich, V.; Smith, E.; Visser, G.; Whitlatch, T.; Wilkin, G.; Zihlmann, B.

2010-01-01

Tests and studies concerning the design and performance of the GlueX Central Drift Chamber (CDC) are presented. A full-scale prototype was built to test and steer the mechanical and electronic design. Small scale prototypes were constructed to test for sagging and to do timing and resolution studies of the detector. These studies were used to choose the gas mixture and to program a Monte Carlo simulation that can predict the detector response in an external magnetic field. Particle identification and charge division possibilities were also investigated.

Uncertainty and sensitivity assessments of an agricultural-hydrological model (RZWQM2) using the GLUE method

Science.gov (United States)

Sun, Mei; Zhang, Xiaolin; Huo, Zailin; Feng, Shaoyuan; Huang, Guanhua; Mao, Xiaomin

2016-03-01

Quantitatively ascertaining and analyzing the effects of model uncertainty on model reliability is a focal point for agricultural-hydrological models due to more uncertainties of inputs and processes. In this study, the generalized likelihood uncertainty estimation (GLUE) method with Latin hypercube sampling (LHS) was used to evaluate the uncertainty of the RZWQM-DSSAT (RZWQM2) model outputs responses and the sensitivity of 25 parameters related to soil properties, nutrient transport and crop genetics. To avoid the one-sided risk of model prediction caused by using a single calibration criterion, the combined likelihood (CL) function integrated information concerning water, nitrogen, and crop production was introduced in GLUE analysis for the predictions of the following four model output responses: the total amount of water content (T-SWC) and the nitrate nitrogen (T-NIT) within the 1-m soil profile, the seed yields of waxy maize (Y-Maize) and winter wheat (Y-Wheat). In the process of evaluating RZWQM2, measurements and meteorological data were obtained from a field experiment that involved a winter wheat and waxy maize crop rotation system conducted from 2003 to 2004 in southern Beijing. The calibration and validation results indicated that RZWQM2 model can be used to simulate the crop growth and water-nitrogen migration and transformation in wheat-maize crop rotation planting system. The results of uncertainty analysis using of GLUE method showed T-NIT was sensitive to parameters relative to nitrification coefficient, maize growth characteristics on seedling period, wheat vernalization period, and wheat photoperiod. Parameters on soil saturated hydraulic conductivity, nitrogen nitrification and denitrification, and urea hydrolysis played an important role in crop yield component. The prediction errors for RZWQM2 outputs with CL function were relatively lower and uniform compared with other likelihood functions composed of individual calibration criterion. This

Design and evaluation of a data-driven scenario generation framework for game-based training

NARCIS (Netherlands)

Luo, L.; Yin, H.; Cai, W.; Zhong, J.; Lees, M.

Generating suitable game scenarios that can cater for individual players has become an emerging challenge in procedural content generation. In this paper, we propose a data-driven scenario generation framework for game-based training. An evolutionary scenario generation process is designed with a

Policy Framework for the Next Generation Platform as a Service

DEFF Research Database (Denmark)

Kentis, Angelos Mimidis; Ollora Zaballa, Eder; Soler, José

2018-01-01

The Platform-as-a-Service (PaaS) model, allows service providers to build and deploy their services following streamlined work-flows. However, platforms deployed through the PaaS model can be very diverse in terms of technologies and involved subsystems (e.g. infrastructure, orchestration). Thus,......-wide and technology-agnostic policies to NGPaaS, by means of abstraction of the underlying platforms and the use of generic interfaces. The paper also presents a specific use case for the proposed framework, which targets network-oriented policies......., the means for deploying and managing a service can significantly vary depending on the deployed platform. To address this issue, this paper proposes a policy-based framework designed for the Next Generation Platform-as-a-Service (NGPaaS). This framework allows service providers to define platform...

Quantum-dot-sensitized solar cells fabricated by the combined process of the direct attachment of colloidal CdSe quantum dots having a ZnS glue layer and spray pyrolysis deposition.

Science.gov (United States)

Im, Sang Hyuk; Lee, Yong Hui; Seok, Sang Il; Kim, Sung Woo; Kim, Sang-Wook

2010-12-07

We were able to attach CdSe quantum dots (QDs) having a ZnS inorganic glue layer directly to a mesoporous TiO(2) (mp-TiO(2)) surface by spray coating and thermal annealing. Quantum-dot-sensitized solar cells based on CdSe QDs having ZnS as the inorganic glue layer could easily transport generated charge carriers because of the intimate bonding between CdSe and mp-TiO(2). The application of spray pyrolysis deposition (SPD) to obtain additional CdSe layers improved the performance characteristics to V(oc) = 0.45 V, J(sc) = 10.7 mA/cm(2), fill factor = 35.8%, and power conversion efficiency = 1.7%. Furthermore, ZnS post-treatment improved the device performance to V(oc) = 0.57 V, J(sc) = 11.2 mA/cm(2), fill factor = 35.4%, and power conversion efficiency = 2.2%.

2-octyl-cyanoacrylate glue for fixation of STSG in genitourinary tissue defects due to Fournier gangrene: a preliminary trial.

Science.gov (United States)

Sivrioğlu, Nazan; Irkören, Saime; Ceylan, Ender; Sonel, Ali Murat; Copçu, Eray

2013-05-01

In these reported cases, we observed the outcomes of skin take and wound healing using 2-octyl-cyanoacrylate glue, which was used as tissue glue in the reconstruction of complex genital skin loss due to fournier gangrene. Fifteen patients with Fournier's gangrene were treated in this study. After initial surgical debridement, all defects were repaired using STSG. In this method a thin layer of 2-octyl-cyanoacrylate was dripped on the recipient site immediately before graft application. All wounds were followed up postoperatively and observed for evidence of graft take, seroma or hematoma formation, drainage, and infection. Patient and physician satisfaction were also determined. Grafts were completely accepted in all fifteen patients. None of the patients had wound infection, seroma, hematoma, or other complications. Use of 2-octyl-cyanoacrylate glue (Glueseal) for STSG fixation in complex genital skin defects after Fournier gangrene may be an acceptable alternative to conventional surgical closure with a good cosmetic outcome. Further studies are needed to confirm our initial success with this approach.

Transarterial microcatheter glue embolization of the bronchial artery for life-threatening hemoptysis: Technical and clinical results

Energy Technology Data Exchange (ETDEWEB)

Baltacioglu, Feyyaz [Marmara University School of Medicine, Department of Radiology, Istanbul (Turkey)], E-mail: fbaltaci@yahoo.com; Cimsit, Nuri Cagatay [Marmara University School of Medicine, Department of Radiology, Istanbul (Turkey)], E-mail: cagataycimsit@gmail.com; Bostanci, Korkut [Marmara University School of Medicine, Department of Thoracic Surgery, Istanbul (Turkey)], E-mail: kbostanci@marmara.edu.tr; Yueksel, Mustafa [Marmara University School of Medicine, Department of Thoracic Surgery, Istanbul (Turkey)], E-mail: myuksel@marmara.edu.tr; Kodalli, Nihat [Marmara University School of Medicine, Department of Radiology, Istanbul (Turkey)], E-mail: nihatkodalli@yahoo.com

2010-02-15

Objectives: To report our experience with transarterial glue embolization of the bronchial artery for life-threatening hemoptysis. Materials and methods: Twenty-five patients underwent bronchial artery embolization, using coaxial microcatheter technique, with a liquid agent, n-butyl-2-cyanoacrylate (NBCA), named glue, for life-threatening hemoptysis. The technical and clinical outcomes were followed in terms of immediate control of bleeding, recurrence of hemoptysis and complications of the procedure. Results: Four patients had acute hemoptysis when they were evaluated. The average number of arteries embolized per patient was 2.9. BAEs were successful in controlling hemoptysis immediately in all 25 patients (100%) and in 24 patients (96%) at 1 month follow-ups. One patient had recurrent hemoptysis on the tenth day after embolization. The follow-up time ranged from 2 to 63 months (mean 14 months). Six patients (25%) died all as a result of their disease process. Bleeding recurred in 3 patients after 30 days (7th, 11th, 12th months). One patient had vomitting attacks with dysphagia after the procedure that lasted 24 h. Three patients had transient thoracic pain lasting 3-5 days. There were no procedure related spinal or vascular complications. Conclusions: Glue embolization with microcatheter technique is a safe and effective treatment in cases of life-threatening hemoptysis with a very high rate of success and low rate of complications.

Glue ear: how good is the information on the World Wide Web?

Science.gov (United States)

Ritchie, L; Tornari, C; Patel, P M; Lakhani, R

2016-02-01

This paper objectively evaluates current information available to the general public related to glue ear on the World Wide Web. The term 'glue ear' was typed into the 3 most frequently used internet search engines - Google, Bing and Yahoo - and the first 20 links were analysed. The first 400 words of each page were used to calculate the Flesch-Kincaid readability score. Each website was subsequently graded using the Discern instrument, which gauges quality and content of literature. The websites Webmd.boots.com, Bupa.co.uk and Patient.co.uk received the highest overall scores. These reflected top scores in either readability or Discern instrument assessment, but not both. Readability and Discern scores increased with the presence of a marketing or advertising incentive. The Patient.co.uk website had the highest Discern score and third highest readability score. There is huge variation in the quality of information available to patients on the internet. Some websites may be accessible to a wide range of reading ages but have poor quality content, and vice versa. Clinicians should be aware of indicators of quality, and use validated instruments to assess and recommend literature.

Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers: experimental study in dogs (Canis familiaris, Linnaeus, 1758

Directory of Open Access Journals (Sweden)

R. L. Sampaio

2007-01-01

Full Text Available Fibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth. Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing.

Conceptual framework for the study of food waste generation and prevention in the hospitality sector.

Science.gov (United States)

Papargyropoulou, Effie; Wright, Nigel; Lozano, Rodrigo; Steinberger, Julia; Padfield, Rory; Ujang, Zaini

2016-03-01

Food waste has significant detrimental economic, environmental and social impacts. The magnitude and complexity of the global food waste problem has brought it to the forefront of the environmental agenda; however, there has been little research on the patterns and drivers of food waste generation, especially outside the household. This is partially due to weaknesses in the methodological approaches used to understand such a complex problem. This paper proposes a novel conceptual framework to identify and explain the patterns and drivers of food waste generation in the hospitality sector, with the aim of identifying food waste prevention measures. This conceptual framework integrates data collection and analysis methods from ethnography and grounded theory, complemented with concepts and tools from industrial ecology for the analysis of quantitative data. A case study of food waste generation at a hotel restaurant in Malaysia is used as an example to illustrate how this conceptual framework can be applied. The conceptual framework links the biophysical and economic flows of food provisioning and waste generation, with the social and cultural practices associated with food preparation and consumption. The case study demonstrates that food waste is intrinsically linked to the way we provision and consume food, the material and socio-cultural context of food consumption and food waste generation. Food provisioning, food consumption and food waste generation should be studied together in order to fully understand how, where and most importantly why food waste is generated. This understanding will then enable to draw detailed, case specific food waste prevention plans addressing the material and socio-economic aspects of food waste generation. Copyright © 2016 Elsevier Ltd. All rights reserved.

Analysis of stress- strain distribution of dowel and glue line in L-type furniture joint by means of finite element method

Directory of Open Access Journals (Sweden)

mossayeb dalvand

2017-08-01

Full Text Available In this study 3D stress-strain distribution of dowel and glue line on L-type joints made of plywood doweled was investigated. Members of joints made of 11-ply hardwood plywood (Hornbeam, Beech and Alder that were 19 mm in thickness. In this study effect of beech dowels in three levels diameters (6, 8 and 10 mm and penetration of depth (9, 13 and 17 mm on bending moment capacity of L-type joints under compression loading was investigated as experimental test, then stress-strain distribution of wood dowel and glue line in specimens were simulated by means of ANSYS 15 software with finite element method (FEM.Results have shown that bending moment resistance increased with increasing dowel diameter from 6 to 8 mm, but downward trend was observed with increasing 8 to 10 mm in dowel diameter. Bending moment resistance increased with increasing penetration depth. Also, result obtained of simulation by means of ANSYS software have shown that stress-strain in dowel and glue line increased with increasing diameter of dowel and Increasing stress in joints made of diameter dowel 10 mm due to fracture in joints and decrease in resistance once. According to results obtained of model analysis, the ultimate stress of dowel and glue line occurred in the area that joints were contacted.

Performance of fast-absorbable suture and histo-glue in closing incisions in Brown trout

DEFF Research Database (Denmark)

Jepsen, Niels; Larsen, Martin Hage; Aarestrup, Kim

2017-01-01

, growth, tag expulsion rate and incision healing was compared among three groups of dummy transmitter-tagged wild brown trout Salmo trutta where incisions were closed with two types of suture material (absorbable vs. fast absorbable) and Histo-glue. The tagged fish were kept in semi-natural ponds for 20...

Straightforward Generation of Pillared, Microporous Graphene Frameworks for Use in Supercapacitors.

Science.gov (United States)

Yuan, Kai; Xu, Yazhou; Uihlein, Johannes; Brunklaus, Gunther; Shi, Lei; Heiderhoff, Ralf; Que, Mingming; Forster, Michael; Chassé, Thomas; Pichler, Thomas; Riedl, Thomas; Chen, Yiwang; Scherf, Ullrich

2015-11-01

Microporous, pillared graphene-based frameworks are generated in a simple functionalization/coupling procedure starting from reduced graphene oxide. They are used for the fabrication of high-performance supercapacitor devices. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A platform independent framework for Statecharts code generation

International Nuclear Information System (INIS)

Andolfato, L.; Chiozzi, G.; Migliorini, N.; Morales, C.

2012-01-01

Control systems for telescopes and their instruments are reactive systems very well suited to be modelled using Statecharts formalism. The World Wide Web Consortium is working on a new standard called SCXML that specifies XML notation to describe Statecharts and provides a well defined operational semantic for run-time interpretation of the SCXML models. This paper presents a generic application framework for reactive non realtime systems based on interpreted Statecharts. The framework consists of a model to text transformation tool and an SCXML interpreter. The tool generates from UML state machine models the SCXML representation of the state machines as well as the application skeletons for the supported software platforms. An abstraction layer propagates the events from the middle-ware to the SCXML interpreter facilitating the support for different software platforms. This project benefits from the positive experience gained in several years of development of coordination and monitoring applications for the telescope control software domain using Model Driven Development technologies. (authors)

Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue.

NARCIS (Netherlands)

Hallers, E.J.O. ten; Jansen, J.A.; Marres, H.A.M.; Rakhorst, G.; Verkerke, G.J.

2007-01-01

Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and

Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue

NARCIS (Netherlands)

ten Hallers, E.J. Olivier; Jansen, John A.; Marres, Henri A.M.; Rakhorst, Gerhard; Verkerke, Gijsbertus Jacob

2007-01-01

Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and

Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue

NARCIS (Netherlands)

ten Hallers, E. J. Olivier; Jansen, John A.; Marres, Henri A. M.; Rakhorst, Gerhard; Verkerke, Gijsbertus J.

Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and

DARC: Next generation decentralized control framework for robot applications

DEFF Research Database (Denmark)

Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

2013-01-01

This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry....... It incorporates several new techniques such as a decentralized peer-to-peer architecture, transparent network distribution of the control system, and automatic run-time supervision to guarantee robustness....

A Framework for Assessing the Commercialization of Photovoltaic Power Generation

Science.gov (United States)

Yaqub, Mahdi

An effective framework does not currently exist with which to assess the viability of commercializing photovoltaic (PV) power generation in the US energy market. Adopting a new technology, such as utility-scale PV power generation, requires a commercialization assessment framework. The framework developed here assesses the economic viability of a set of alternatives of identified factors. Economic viability focuses on simulating the levelized cost of electricity (LCOE) as a key performance measure to realize `grid parity', or the equivalence between the PV electricity prices and grid electricity prices for established energy technologies. Simulation results confirm that `grid parity' could be achieved without the current federal 30% investment tax credit (ITC) via a combination of three strategies: 1) using economies of scale to reduce the LCOE by 30% from its current value of 3.6 cents/kWh to 2.5 cents/kWh, 2) employing a longer power purchase agreement (PPA) over 30 years at a 4% interest rate, and 3) improving by 15% the "capacity factor", which is the ratio of the total annual generated energy to the full potential annual generation when the utility is continuously operating at its rated output. The lower than commercial-market interest rate of 4% that is needed to realize `grid parity' is intended to replace the current federal 30% ITC subsidy, which does not have a cash inflow to offset the outflow of subsidy payments. The 4% interest rate can be realized through two proposed finance plans: The first plan involves the implementation of carbon fees on polluting power plants to produce the capital needed to lower the utility PPA loan term interest rate from its current 7% to the necessary 4% rate. The second plan entails a proposed public debt finance plan. Under this plan, the US Government leverages its guarantee power to issue bonds and uses the proceeds to finance the construction and operation of PV power plants with PPA loan with a 4% interest rate for a

Framework Programmable Platform for the Advanced Software Development Workstation: Preliminary system design document

Science.gov (United States)

Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Ackley, Keith A.; Crump, John W., IV; Henderson, Richard; Futrell, Michael T.

1991-01-01

The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software environment. Guided by the model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated. The focus here is on the design of components that make up the FPP. These components serve as supporting systems for the Integration Mechanism and the Framework Processor and provide the 'glue' that ties the FPP together. Also discussed are the components that allow the platform to operate in a distributed, heterogeneous environment and to manage the development and evolution of software system artifacts.

Peptide assembly-driven metal-organic framework (MOF) motors for micro electric generators.

Science.gov (United States)

Ikezoe, Yasuhiro; Fang, Justin; Wasik, Tomasz L; Uemura, Takashi; Zheng, Yongtai; Kitagawa, Susumu; Matsui, Hiroshi

2015-01-14

Peptide-metal-organic framework (Pep-MOF) motors, whose motions are driven by anisotropic surface tension gradients created via peptide self-assembly around frameworks, can rotate microscopic rotors and magnets fast enough to generate an electric power of 0.1 μW. A new rigid Pep-MOF motor can be recycled by refilling the peptide fuel into the nanopores of the MOF. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A unique and unexplained ricochet leak post PCI – Successfully treated with intra-coronary glue

Directory of Open Access Journals (Sweden)

Pravin K. Goel

2014-01-01

Full Text Available We herein describe a unique case of coronary artery perforation treated with covered stent with repeat cardiac tamponade resulting out of a fresh unexplained leak from a remote vessel (Ricochet and successfully treated with intra-coronary injection of sterile synthetic glue, cyanoacrylate.

EFFICACY OF THROMBIN FIBRIN GLUE AND SCLE ROSANT IN THE MANAGEMENT OF BLEEDI NG GASTRIC VARICES

Directory of Open Access Journals (Sweden)

Sanjay Gupta

2015-01-01

Full Text Available Gastric varices are noted in up to 20 % of patents with portal hypertension , and are more common in those with non - cirrhotic etiology 1 . They bleed at lower portal pressures , bleed more severely and are associated with higher rates of rebleed , encephalopathy and mortality 1,2,3 . Variceal obliteration using tissue adhesives such as N - butyl cyanoacrylate leading to plugging and thrombosis of the gastric varices is currently the first line management option for obliteration of the gastric varices 3 . Although various options have been proposed , gold standard for management of gastric variceal bleeds is yet to be defined. We theorized that injection of the gastric varices using thrombin based glue followed by injection of a sclerosant shall be effective in optimum sclerotherapy and eradication of gastric varices. MATERIAL AND METHODS : All patients presenting with gastric variceal bleed were offered sclerotherapy with Thrombin fibrin based glue and sclerosant (TFG/S . During the study period 18 patients were enrolled in the TGF/S group. 21 patients underwent variceal plugging with n - butyl cyanoacrylate (NBC . There was no significant difference in age/ sex , duration of bleed or time interval between onset of bleed and endotherapy. RESULTS: Patients undergoing endotherapy with TGF/S had less episodes of bleed , and greater eradication of varices. CONCLUSION: The results with thrombin / fibrin glue and sclerotherapy are highly encouraging. Well - designed trials need to be performed KEYWORDS:Gastric varices; Thrombin Sclerotherapy

Strenght of the glue line of edge glued panels of Pinus taeda made with different adhesives

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Merielen de Carvalho Lopes

2013-12-01

Full Text Available The study compares the strength of the glue line of edge glued panels of Pinus taeda made with different industrial adhesives. Three types of adhesives (poly(vinyl acetate (PVAc, emulsion polymer isocyanate (EPI and polyurethane (PU glued in two side gluing orientation (radial and tangential and analyzed after the conditioning tests (dry and wet were analyzed. The 360 specimens were prepared for determining the shear strength of edge glued panels of Pinus taeda, and these were tested in a universal testing machine called EMIC. The shear strength of the glue line at dry condition was lower in the tangential side for the three types of adhesives analyzed. The PU adhesive showed the highest values of shear strength in the applied conditions, differing from PVAc and EPI adhesive when tested on dry condition and did not differ from the others adhesives when tested on wet condition. The highest percentage of wood failure was observed after the shear strength test at dry condition to EPI adhesive glued in the radial side. And in the wet condition, the EPI adhesive and PU adhesive glued in tangential side showed higher mean values of wood failure. Thus, it was possible to conclude that the strength of the glue line of Pinus taeda wood was influenced by the type of adhesive and side gluing orientation, and showed differently behavior according to the condition of use (wet or dry.

Humidity control and hydrophilic glue coating applied to mounted protein crystals improves X-ray diffraction experiments

Science.gov (United States)

Baba, Seiki; Hoshino, Takeshi; Ito, Len; Kumasaka, Takashi

2013-01-01

Protein crystals are fragile, and it is sometimes difficult to find conditions suitable for handling and cryocooling the crystals before conducting X-ray diffraction experiments. To overcome this issue, a protein crystal-mounting method has been developed that involves a water-soluble polymer and controlled humid air that can adjust the moisture content of a mounted crystal. By coating crystals with polymer glue and exposing them to controlled humid air, the crystals were stable at room temperature and were cryocooled under optimized humidity. Moreover, the glue-coated crystals reproducibly showed gradual transformations of their lattice constants in response to a change in humidity; thus, using this method, a series of isomorphous crystals can be prepared. This technique is valuable when working on fragile protein crystals, including membrane proteins, and will also be useful for multi-crystal data collection. PMID:23999307

Effect of fibrin glue derived from snake venom on the viability of autogenous split-thickness skin graft

Directory of Open Access Journals (Sweden)

S.C. Rahal

2004-01-01

Full Text Available The aim of this study was to analyze the effect of snake venom derived from fibrin glue on the viability of split-thickness skin graft. Nine crossbreed dogs were used. Full-thickness skin segments measuring 4 x 4 cm were bilaterally excised from the proximal radial area on each dog. A split-thickness skin graft was harvestedfrom left lateral thoracic area using a freehand graft knife, and was secured to the left recipient bed using several simple interrupted sutures of 3-0 nylon (sutured graft. A split-thickness skin graft was harvested from the right lateral thoracic area using a graft knife. Fibrin glue derived from snake venom was applied to the recipient bed, and 8 equidistant simple interrupted sutures of 3-0 nylon were used to secure the skin graft (glued graft. Viable and nonviable areas were traced on a transparent sheet and measured using a Nikon Photomicroscope connected to a KS-300 image analysis system. The skin graft and recipient bed were collected from three dogs at day 7, 15, and 30 postoperative. The glued grafts had statistically higher graft viability than sutured grafts. Histological examination showed that the tissue repair process in the glued grafts was more accentuated than sutured grafts. It was possible to conclude that fibrin glue derived from snake venom increased survival of autogenous split-thickness skin graft.

Development of Self Fire Retardant Melamine-Animal Glue Formaldehyde (MGF) Resin for the Manufacture of BWR Ply Board

Science.gov (United States)

Khatua, Pijus Kanti; Dubey, Rajib Kumar; Roymahapatra, Gourisankar; Mishra, Anjan; Shahoo, Shadhu Charan; Kalawate, Aparna

2017-10-01

Wood is one of the most sustainable, naturally growing materials that consist mainly of combustible organic carbon compounds. Since plywood are widely used nowadays especially in buildings, furniture and cabinets. Too often the fire behavior of ply-board may be viewed as a drawback. Amino-plastic based thermosetting resin adhesives are the important and most widely used in the plywood panel industries. The fire retardant property of wood panel products by adding animal glue as an additive in the form of MGF resin and used as substitute of melamine for manufacture of plywood. Environment concerns and higher cost of petroleum based resins have resulted in the development of technologies to replace melamine partially by biomaterials for the manufacturing of resin adhesive. Natural bio-based materials such as tannin, CNSL (cardanol), lignin, soya etc. are used as partial substitution of melamine. This article presents the development of melamine-animal glue formaldehyde resin as plywood binder. About 30 % melamine was substituted by animal glue and optimized. The different physico-mechanical and fire retardant property properties tested as per IS: 1734-1983 and IS: 5509-2000 respectively are quite satisfactory. The production of adhesive from melamine with compatible natural proteinous material is cost effective, eco-friendly and enhance the fire retardant property.

An automated framework for hypotheses generation using literature

Directory of Open Access Journals (Sweden)

Abedi Vida

2012-08-01

Full Text Available Abstract Background In bio-medicine, exploratory studies and hypothesis generation often begin with researching existing literature to identify a set of factors and their association with diseases, phenotypes, or biological processes. Many scientists are overwhelmed by the sheer volume of literature on a disease when they plan to generate a new hypothesis or study a biological phenomenon. The situation is even worse for junior investigators who often find it difficult to formulate new hypotheses or, more importantly, corroborate if their hypothesis is consistent with existing literature. It is a daunting task to be abreast with so much being published and also remember all combinations of direct and indirect associations. Fortunately there is a growing trend of using literature mining and knowledge discovery tools in biomedical research. However, there is still a large gap between the huge amount of effort and resources invested in disease research and the little effort in harvesting the published knowledge. The proposed hypothesis generation framework (HGF finds “crisp semantic associations” among entities of interest - that is a step towards bridging such gaps. Methodology The proposed HGF shares similar end goals like the SWAN but are more holistic in nature and was designed and implemented using scalable and efficient computational models of disease-disease interaction. The integration of mapping ontologies with latent semantic analysis is critical in capturing domain specific direct and indirect “crisp” associations, and making assertions about entities (such as disease X is associated with a set of factors Z. Results Pilot studies were performed using two diseases. A comparative analysis of the computed “associations” and “assertions” with curated expert knowledge was performed to validate the results. It was observed that the HGF is able to capture “crisp” direct and indirect associations, and provide knowledge

An automated framework for hypotheses generation using literature.

Science.gov (United States)

Abedi, Vida; Zand, Ramin; Yeasin, Mohammed; Faisal, Fazle Elahi

2012-08-29

In bio-medicine, exploratory studies and hypothesis generation often begin with researching existing literature to identify a set of factors and their association with diseases, phenotypes, or biological processes. Many scientists are overwhelmed by the sheer volume of literature on a disease when they plan to generate a new hypothesis or study a biological phenomenon. The situation is even worse for junior investigators who often find it difficult to formulate new hypotheses or, more importantly, corroborate if their hypothesis is consistent with existing literature. It is a daunting task to be abreast with so much being published and also remember all combinations of direct and indirect associations. Fortunately there is a growing trend of using literature mining and knowledge discovery tools in biomedical research. However, there is still a large gap between the huge amount of effort and resources invested in disease research and the little effort in harvesting the published knowledge. The proposed hypothesis generation framework (HGF) finds "crisp semantic associations" among entities of interest - that is a step towards bridging such gaps. The proposed HGF shares similar end goals like the SWAN but are more holistic in nature and was designed and implemented using scalable and efficient computational models of disease-disease interaction. The integration of mapping ontologies with latent semantic analysis is critical in capturing domain specific direct and indirect "crisp" associations, and making assertions about entities (such as disease X is associated with a set of factors Z). Pilot studies were performed using two diseases. A comparative analysis of the computed "associations" and "assertions" with curated expert knowledge was performed to validate the results. It was observed that the HGF is able to capture "crisp" direct and indirect associations, and provide knowledge discovery on demand. The proposed framework is fast, efficient, and robust in

Migration to the GLUE 2.0 information schema in the LCG/EGEE/EGI production Grid

International Nuclear Information System (INIS)

Burke, Stephen; Field, Laurence; Horat, David

2011-01-01

The GLUE information schema has been in use in the LCG/EGEE production Grid since the first version was released in 2002. In 2008 a major redesign of GLUE, version 2.0, was defined in the context of the Open Grid Forum. The implementation of the publication and use of the new schema is a complex process which needs to be carefully managed to avoid any disruption to the production service, especially in the light of the end of the EGEE project and the transition to the new middleware and operational structures in EGI. In this paper we discuss the LDAP rendering of the schema, the upgrading of the Grid information system to allow both schemas to be used in parallel, the design and rollout of information providers, and the plans for migrating client software which uses the schema information. In particular we consider the implications for the specific requirements of the LCG project, especially regarding storage systems, accounting and monitoring.

Introduction of a potent single-donor fibrin glue for vascular anastomosis: An animal study

Directory of Open Access Journals (Sweden)

Mehdi Rasti Ardakani

2012-01-01

Full Text Available Background: Vascular anastomosis is considered as a difficult surgical procedure. Although different alternative methods have been tried to tackle these difficulties, none were found to be successful. Commercial fibrin glue has recently been used for vascular anastomosis. However, it did not gain popularity due to some limitations such as low tensile strength, rapid removal by the immune system, and risk of transmission of blood-borne viral infections. In this article, we presented a novel method for producing single-donor human fibrin glue and determined its success rate for vascular anastomosis in an animal model. Materials ans Methods : In this study, 3 mL of single-donor fibrin sealant was prepared from 150 mL of whole blood containing 50-70 mg/mL of fibrinogen. The study was performed on 10 dogs and 5 cats. After transection of the carotid artery, both ends were anastomosed by means of 3-4 sutures (Prolene 8-0. The suture line was then sealed with one layer of the new fibrin sealant. After 3-8 weeks, the site of anastomosis was evaluated angiographically and morphologically for healing and possible complications such as thrombosis or aneurysm. Results: In evaluations 3 weeks after the surgery, all arterial anastomoses were patent in dogs, but some degree of subintimal hyperplasia was noted. After 8 weeks, all anastomoses were patent and the degree of subintimal hyperplasia was decreased. In cats on the other hand, after 4 weeks, all anastomoses were patent and subintimal hyperplasia was absent. Conclusions: Single-donor fibrin glue was a quite reliable and practical alternative to minimize suturing and therefore operative time in our animal model. This sealant can easily be obtained from the patient′s whole blood. Its application in humans would require further studies.

[Use of fibrin glue in the prevention of leakage in pancreatico-jejunal anastomoses].

Science.gov (United States)

Stojanović, M; Jeremic, M; Stojanović, P; Stojiljković, M; Gmijović, D; Stanojković, Z; Savić, V; Djordjević, V; Cvetković, Z; Kostov, M; Colović, R

2002-01-01

The aim of this study was to test the protective effects of fibrin sealing on the pancreatico-jejunostomy (PJA), the high-risk anastomosis following pancreas head resection. Experimental study was performed on the mongrel dogs, divided in two groups (20 animals each): Experimental group-with end to end "dunking" PJA, protected by temporary occlusion of the pancreatic duct with fibrin sealant/Tissucol/Immuno Ag/, while control group was without any protective procedure. The animals were followed 5 months in order to study: protective effects of such procedure on the PJA quantified with the percent of anastomotic leakage, effects of the exocrine secretion and effects the endocrine function Results: PJA leakage occurred in 13.33% in control group. No leakage was registered in experimental group. Biochemical, histological and electron microscopic study showed slight transitory elevation of amylase levels. Fibrin glue plug was dissolved and pancreatic juice output was reestablished 12th days postoperatively. Long term follow-up showed no damages of the endocrine and exocrine pancreas. Pancreatic duct occlusion with fibrin glue appeared to be an useful method in the prevention of pancreatico-jejunostomy leakage, without negative effects on the exocrine and endocrine pancreas.

Clinical observation on fibrin glue technique in pterygium surgery performed with limbal autograft transplantation

Directory of Open Access Journals (Sweden)

Hui Liu

2013-07-01

Full Text Available AIM: To compare the efficiency and safety of fibrin glue to suture technique in pterygium surgery performed with limbal autograft.METHODS: A prospective randomized clinical trial was carried out in 60 eyes of 48 patients operated for primary nasal pterygium. Autologous limbal graft taken from the superotemporal limbus was used to cover the sclera after pterygium excision under local anesthesia with 2% lidocaine. In 22 cases(30 eyes, the transplant was attached to the sclera with a fibrin tissue adhesive(group 1and in 26 cases(30 eyeswith 10-0 Virgin silk sutures(group 2. Patients were followed up at least for 3 months. Time of operation, matching degree of graft and visual analogue scale(VASscore were mainly observed and recorded. RESULTS: Patient symptoms were significantly less and biomicroscopic findings were better in group 1. Pterygium recurrence was seen in 1 case of group 1, and 1 case of group 2. Average surgery time was shorter(PCONCLUSION: Using fibrin glue for graft fixation in pterygium surgery causes significantly less postoperative pain and shortens surgery time significantly.

Glue-sniffing as a cause of a positive radio-isotope brain scan

Energy Technology Data Exchange (ETDEWEB)

Lamont, C M; Adams, F G

1982-08-01

Convulsions are a known complication of the acute intoxicant effects of solvent abuse. A radio-isotope brain scan done 9 months following status epilepticus secondary to toluene inhalation, in a previously normal school-boy, demonstrated several wedge-shaped areas of increased uptake, in both cerebral hemispheres, consistent with infarcts. It is worth remembering that a positive brain scan in a young person, with recent onset of epilepsy, may be due to glue-sniffing.

Glue-sniffing as a cause of a positive radio-isotope brain scan

International Nuclear Information System (INIS)

Lamont, C.M.; Adams, F.G.

1982-01-01

Convulsions are a known complication of the acute intoxicant effects of solvent abuse. A radio-isotope brain scan done 9 months following status epilepticus secondary to toluene inhalation, in a previously normal school-boy, demonstrated several wedge-shaped areas if increased uptake, in both cerebral hemispheres, consistent with infarcts. It is worth remembering that a positive brain scan in a young person, with recent onset of epilepsy, may be due to glue-sniffing. (orig.)

Is deintegrated electric generation efficient; A proposed empirical reserach framework

Energy Technology Data Exchange (ETDEWEB)

Fox-Penner, P S [Charles River Associates Incorporated, Boston, Massachusetts (US)

1990-01-01

Partial or complete deregulation of public utility industries, which until recently were regulated even in market-driven economics such as the U.S. are examined. The causes and cures of this phenomenon are discussed. The purpose is to present a framework for examining empirically the net benefits to consumers from one particular form of public utility ''deregulation'': separating or deintegrating electricity generators from transmitters, and deregulating the former. The framework has been developed for this application because U.S. public utility law has permitted this particular form of ''deregulation'' to exist alongside traditional utilities for the past ten years. Hence, data are now available for comparing regulated and deregulated power generators and their interaction with the transmission system. More generally, however, the purpose of this article is to argue that the benefits of regulatory change in public utility industries must be examined on a comprehensive basis. It is not sufficient to examine one stage of the vertical production chain and conclude that deregulation will improve or hinder its performance. Rather, the long-range benefits of various industry regimes should be carefully examined from the standpoint of the consumer at the downstream end of the production process. (author) 41 refs.

[Research of repairing rabbit knee joint cartilage defect by compound material of fibrin glue and decalcified bone matrix (DBM) and chondrocytes].

Science.gov (United States)

He, Jie; Yang, Xiang; Yue, Peng-ju; Wang, Guan-yu; Guo, Ting; Zhao, Jian-ning

2009-07-01

To investigate the feasibility and effectivity of using compound material of fibrin glue and DBM as scaffolds for cartilage tissue engineering. Chondrocytes isolated from articular cartilage were seeded into prepared scaffolds, after incubation for 4 weeks in vitro. Chondrocytes and fibrin glue and DBM constructs were implanted in the joint cave of rabbit. The specimens were excised at the 4th, 8th, 12th week, examined grossly analyzed by haematoxylin cosine, toluidine blues staining and type II collagen immunohistochemistry reaction. Wakitani score was counted to evaluate the repairing effect. Grossly analysis showed some ivory tissue filled the caves after 4 weeks and the caves were full filled with smooth surface after 12 weeks. The microscope showed a good deal of chondrocytes appeared after 8 weeks and more type II collagen than 4 weeks. Twelve weeks later, cartilage lacuna could be observed. The cells arrangement and the amount of type II collagen both showed the same as the natural one. Complicated material of fibrin glue and DBM as scaffolds can be used as scaffolds for cartilage tissue engineering.

ABrowse - a customizable next-generation genome browser framework

Directory of Open Access Journals (Sweden)

Kong Lei

2012-01-01

Full Text Available Abstract Background With the rapid growth of genome sequencing projects, genome browser is becoming indispensable, not only as a visualization system but also as an interactive platform to support open data access and collaborative work. Thus a customizable genome browser framework with rich functions and flexible configuration is needed to facilitate various genome research projects. Results Based on next-generation web technologies, we have developed a general-purpose genome browser framework ABrowse which provides interactive browsing experience, open data access and collaborative work support. By supporting Google-map-like smooth navigation, ABrowse offers end users highly interactive browsing experience. To facilitate further data analysis, multiple data access approaches are supported for external platforms to retrieve data from ABrowse. To promote collaborative work, an online user-space is provided for end users to create, store and share comments, annotations and landmarks. For data providers, ABrowse is highly customizable and configurable. The framework provides a set of utilities to import annotation data conveniently. To build ABrowse on existing annotation databases, data providers could specify SQL statements according to database schema. And customized pages for detailed information display of annotation entries could be easily plugged in. For developers, new drawing strategies could be integrated into ABrowse for new types of annotation data. In addition, standard web service is provided for data retrieval remotely, providing underlying machine-oriented programming interface for open data access. Conclusions ABrowse framework is valuable for end users, data providers and developers by providing rich user functions and flexible customization approaches. The source code is published under GNU Lesser General Public License v3.0 and is accessible at http://www.abrowse.org/. To demonstrate all the features of ABrowse, a live demo for

ABrowse--a customizable next-generation genome browser framework.

Science.gov (United States)

Kong, Lei; Wang, Jun; Zhao, Shuqi; Gu, Xiaocheng; Luo, Jingchu; Gao, Ge

2012-01-05

With the rapid growth of genome sequencing projects, genome browser is becoming indispensable, not only as a visualization system but also as an interactive platform to support open data access and collaborative work. Thus a customizable genome browser framework with rich functions and flexible configuration is needed to facilitate various genome research projects. Based on next-generation web technologies, we have developed a general-purpose genome browser framework ABrowse which provides interactive browsing experience, open data access and collaborative work support. By supporting Google-map-like smooth navigation, ABrowse offers end users highly interactive browsing experience. To facilitate further data analysis, multiple data access approaches are supported for external platforms to retrieve data from ABrowse. To promote collaborative work, an online user-space is provided for end users to create, store and share comments, annotations and landmarks. For data providers, ABrowse is highly customizable and configurable. The framework provides a set of utilities to import annotation data conveniently. To build ABrowse on existing annotation databases, data providers could specify SQL statements according to database schema. And customized pages for detailed information display of annotation entries could be easily plugged in. For developers, new drawing strategies could be integrated into ABrowse for new types of annotation data. In addition, standard web service is provided for data retrieval remotely, providing underlying machine-oriented programming interface for open data access. ABrowse framework is valuable for end users, data providers and developers by providing rich user functions and flexible customization approaches. The source code is published under GNU Lesser General Public License v3.0 and is accessible at http://www.abrowse.org/. To demonstrate all the features of ABrowse, a live demo for Arabidopsis thaliana genome has been built at http://arabidopsis.cbi.edu.cn/.

ABrowse - a customizable next-generation genome browser framework

Science.gov (United States)

2012-01-01

Background With the rapid growth of genome sequencing projects, genome browser is becoming indispensable, not only as a visualization system but also as an interactive platform to support open data access and collaborative work. Thus a customizable genome browser framework with rich functions and flexible configuration is needed to facilitate various genome research projects. Results Based on next-generation web technologies, we have developed a general-purpose genome browser framework ABrowse which provides interactive browsing experience, open data access and collaborative work support. By supporting Google-map-like smooth navigation, ABrowse offers end users highly interactive browsing experience. To facilitate further data analysis, multiple data access approaches are supported for external platforms to retrieve data from ABrowse. To promote collaborative work, an online user-space is provided for end users to create, store and share comments, annotations and landmarks. For data providers, ABrowse is highly customizable and configurable. The framework provides a set of utilities to import annotation data conveniently. To build ABrowse on existing annotation databases, data providers could specify SQL statements according to database schema. And customized pages for detailed information display of annotation entries could be easily plugged in. For developers, new drawing strategies could be integrated into ABrowse for new types of annotation data. In addition, standard web service is provided for data retrieval remotely, providing underlying machine-oriented programming interface for open data access. Conclusions ABrowse framework is valuable for end users, data providers and developers by providing rich user functions and flexible customization approaches. The source code is published under GNU Lesser General Public License v3.0 and is accessible at http://www.abrowse.org/. To demonstrate all the features of ABrowse, a live demo for Arabidopsis thaliana genome

Information Warfare: using the viable system model as a framework to attack organisations

Directory of Open Access Journals (Sweden)

Bill Hutchinson

2002-05-01

Full Text Available Information is the glue in any organization. It is needed for policy, decision-making, control, and co-ordination. If an organisation's information systems are disrupted or destroyed, then damage to the whole inevitably follows. This paper uses a proven systemic, analytic framework the Viable System Model (VSM - in a functionalist mode, to analyse the vulnerabilities of an organisation's information resources to this form of aggression. It examines the tactics available, and where they can be used to effectively attack an organisation.

Design and Fabrication of Calibration Device for Scintillating Fibers of Tagger Microscope: For use in GlueX's QCD Experiment

Science.gov (United States)

Briere, Emily

2012-10-01

For decades, scientists have struggled to understand the chromo-electromagnetic field which confines quarks and gluons within the hadron. GlueX is a QCD experiment centered at Jefferson Lab, Virginia, seeking to better understand this gluonic field by exciting it and mapping the spectrum of exotic hybrid mesons that it generates. The experiment uses coherent bremsstrahlung radiation to produce a beam of photons, which due to their polarity act as virtual vector mesons. When incident on a liquid hydrogen target, these mesons are expected to form exotic hybrid mesons. Such particles quickly decay into new particles which are captured in a solenoid detector. The decays can then be reconstructed to examine the properties of the original exotic hybrid meson, although the initial energy of the photon is required to draw meaningful conclusions. The post-bremsstrahlung degraded electrons are bent from the main beam into the tagger microscope where they strike an array of scintillating optical fibers. Given the correlation between momentum and radial bend, the Silicon Photmultiplier sensors attached to the optical fibers are able to ``tag'' the electrons', and thus the photons', initial energies based on which fibers were hit. Providing central data for GlueX, the tagger microscope must be accurate. This paper details the design and fabrication of a scintillating fiber calibration device that moves horizontally above fiber bundles, using a green laser diode to direct light pulses into the fibers. This calibration method has been tested mechanically and via a Monte Carlo Matlab simulation, and has proven to be effective.

The Socioculturally Constructed Multivoiced Self as a Framework for Christian Education of Second-Generation Korean American Young Adults

Science.gov (United States)

Kang, S. Steve

2002-01-01

This article proposes a new framework for theory and practice of Christian education for second-generation Korean American young adults using the literature of sociocultural constructionism and the multivoiced self. This framework can provide holistic nurture and future trajectories in which to encourage a reflexive, praxis-generating faith. The…

Elaboración de cola de pergamino = Preparation of parchment glue

OpenAIRE

Tacón Clavaín, Javier

2013-01-01

En las páginas siguientes se describe mediante imágenes el proceso llevado a cabo en el Departamento de Conservación y Restauración para la elaboración de cola de pergamino. Este adhesivo tradicional es muy adecuado para su uso en consolidaciones y adhesiones en el campo de la restauración documental por su pureza y por su pH neutro. [ABSTRACT]In the following pages the process carried out in the Department of Conservation and Restoration for making parchment glue is described. This tradit...

Mesh fixation in laparoscopic incisional hernia repair: glue fixation provides attachment strength similar to absorbable tacks but differs substantially in different meshes.

Science.gov (United States)

Rieder, Erwin; Stoiber, Martin; Scheikl, Verena; Poglitsch, Marcus; Dal Borgo, Andrea; Prager, Gerhard; Schima, Heinrich

2011-01-01

Laparoscopic ventral hernia repair has gained popularity among minimally invasive surgeons. However, mesh fixation remains a matter of discussion. This study was designed to compare noninvasive fibrin-glue attachment with tack fixation of meshes developed primarily for intra-abdominal use. It was hypothesized that particular mesh structures would substantially influence detachment force. For initial evaluation, specimens of laminated polypropylene/polydioxanone meshes were anchored to porcine abdominal walls by either helical titanium tacks or absorbable tacks in vitro. A universal tensile-testing machine was used to measure tangential detachment forces (TF). For subsequent experiments of glue fixation, polypropylene/polydioxanone mesh and 4 additional meshes with diverse particular mesh structure, ie, polyvinylidene fluoride/polypropylene mesh, a titanium-coated polypropylene mesh, a polyester mesh bonded with a resorbable collagen, and a macroporous condensed PTFE mesh were evaluated. TF tests revealed that fibrin-glue attachment was not substantially different from that achieved with absorbable tacks (median TF 7.8 Newton [N], range 1.3 to 15.8 N), but only when certain open porous meshes (polyvinylidene fluoride/polypropylene mesh: median 6.2 N, range 3.4 to 10.3 N; titanium-coated polypropylene mesh: median 5.2 N, range 2.1 to 11.7 N) were used. Meshes coated by an anti-adhesive barrier (polypropylene/polydioxanone mesh: median 3.1 N, range 1.7 to 5.8 N; polyester mesh bonded with a resorbable collagen: median 1.3 N, range 0.5 to 1.9 N), or the condensed PTFE mesh (median 3.1 N, range 2.1 to 7.0 N) provided a significantly lower TF (p < 0.01). Fibrin glue appears to be an appealing noninvasive option for mesh fixation in laparoscopic ventral hernia repair, but only if appropriate meshes are used. Glue can also serve as an adjunct to mechanical fixation to reduce the number of invasive tacks. Copyright © 2010 American College of Surgeons. Published by Elsevier

Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats

Science.gov (United States)

Despoudi, Kalliopi; Mantzoros, Ioannis; Ioannidis, Orestis; Cheva, Aggeliki; Antoniou, Nikolaos; Konstantaras, Dimitrios; Symeonidis, Savvas; Pramateftakis, Manousos George; Kotidis, Efstathios; Angelopoulos, Stamatis; Tsalis, Konstantinos

2017-01-01

AIM To evaluate the effect of local surgical adhesive glue (albumin/glutaraldehyde-Bioglue) on the healing of colonic anastomoses in rats. METHODS Forty Albino-Wistar male rats were randomly divided into two groups, with two subgroups of ten animals each. In the control group, an end-to-end colonic anastomosis was performed after segmental resection. In the Bioglue group, the anastomosis was protected with extraluminar application of adhesive glue containing albumin and glutaraldehyde. Half of the rats were sacrificed on the fourth and the rest on the eighth postoperative day. Anastomoses were resected and macroscopically examined. Bursting pressures were calculated and histological features were graded. Other parameters of healing, such as hydroxyproline and collagenase concentrations, were evaluated. The experimental data were summarized and computed from the results of a one-way ANOVA. Fisher’s exact test was applied to compare percentages. RESULTS Bursting pressures, adhesion formation, inflammatory cell infiltration, and collagen deposition were significantly higher on the fourth postoperative day in the albumin/glutaraldehyde group than in the control group. Furthermore, albumin/glutaraldehyde significantly increased adhesion formation, inflammatory cell infiltration, neoangiogenesis, and collagen deposition on the eighth postoperative day. There was no difference in fibroblast activity or hydroxyproline and collagenase concentrations. CONCLUSION Albumin/glutaraldehyde, when applied on colonic anastomoses, promotes their healing in rats. Therefore, the application of protective local agents in colonic anastomoses leads to better outcomes. PMID:28883693

Automatic Model Generation Framework for Computational Simulation of Cochlear Implantation

DEFF Research Database (Denmark)

Mangado Lopez, Nerea; Ceresa, Mario; Duchateau, Nicolas

2016-01-01

. To address such a challenge, we propose an automatic framework for the generation of patient-specific meshes for finite element modeling of the implanted cochlea. First, a statistical shape model is constructed from high-resolution anatomical μCT images. Then, by fitting the statistical model to a patient......'s CT image, an accurate model of the patient-specific cochlea anatomy is obtained. An algorithm based on the parallel transport frame is employed to perform the virtual insertion of the cochlear implant. Our automatic framework also incorporates the surrounding bone and nerve fibers and assigns......Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging...

Supporting an Object-Oriented Approach to Unit Generator Development: The Csound Plugin Opcode Framework

Directory of Open Access Journals (Sweden)

Victor Lazzarini

2017-09-01

Full Text Available This article presents a new framework for unit generator development for Csound, supporting a full object-oriented programming approach. It introduces the concept of unit generators and opcodes, and its centrality with regards to music programming languages in general, and Csound in specific. The layout of an opcode from the perspective of the Csound C-language API is presented, with some outline code examples. This is followed by a discussion which places the unit generator within the object-oriented paradigm and the motivation for a full C++ programming support, which is provided by the Csound Plugin Opcode Framework (CPOF. The design of CPOF is then explored in detail, supported by several opcode examples. The article concludes by discussing two key applications of object-orientation and their respective instances in the Csound code base.

Inorganic Glue Enabling High Performance of Silicon Particles as Lithium Ion Battery Anode

KAUST Repository

Cui, Li-Feng

2011-01-01

Silicon, as an alloy-type anode material, has recently attracted lots of attention because of its highest known Li+ storage capacity (4200 mAh/g). But lithium insertion into and extraction from silicon are accompanied by a huge volume change, up to 300, which induces a strong strain on silicon and causes pulverization and rapid capacity fading due to the loss of the electrical contact between part of silicon and current collector. Silicon nanostructures such as nanowires and nanotubes can overcome the pulverization problem, however these nano-engineered silicon anodes usually involve very expensive processes and have difficulty being applied in commercial lithium ion batteries. In this study, we report a novel method using amorphous silicon as inorganic glue replacing conventional polymer binder. This inorganic glue method can solve the loss of contact issue in conventional silicon particle anode and enables successful cycling of various sizes of silicon particles, both nano-particles and micron particles. With a limited capacity of 800 mAh/g, relatively large silicon micron-particles can be stably cycled over 200 cycles. The very cheap production of these silicon particle anodes makes our method promising and competitive in lithium ion battery industry. © 2011 The Electrochemical Society.

Recommendations for institutional policy and network regulatory frameworks towards distributed generation in EU Member States

International Nuclear Information System (INIS)

Ten Donkelaar, M.; Van Oostvoorn, F.

2005-01-01

Recommendations regarding the development of regulatory frameworks and institutional policies towards an optimal integration of distributed generation (DG) into electricity networks are presented. These recommendations are based on findings from a benchmarking study conducted in the framework of the ENIRDG-net project. The aim of the benchmarking exercise was to identify examples of well-defined pro-DG policies, with clear targets and adequate implementation mechanisms. In this study an adequate pro-DG policy is defined on the basis of a level playing field, a situation where distributed and centralised generation receive equal incentives and have equal access to the liberalised markets for electricity. The benchmark study includes the results of a similar study conducted in the framework of the SUSTELNET project. When comparing the results a certain discrepancy can be noticed between the actual regulation and policy in a number of countries, the medium to long-term targets and the ideal situation described by the level playing field objective. To overcome this discrepancy, a number of recommendations have been drafted for future policy and regulation towards distributed generation

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses

DEFF Research Database (Denmark)

Nordentoft, Tyge; Pommergaard, Hans-Christian; Rosenberg, Jacob

2015-01-01

BACKGROUND/AIM: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin...... glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence....... It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se....

Comparative uncertainty analysis of copper loads in stormwater systems using GLUE and grey-box modeling

DEFF Research Database (Denmark)

Lindblom, Erik Ulfson; Madsen, Henrik; Mikkelsen, Peter Steen

2007-01-01

. With the proposed model and input data, the GLUE analysis show that the total sampled copper mass can be predicted within a range of +/- 50% of the median value ( 385 g), whereas the grey-box analysis showed a prediction uncertainty of less than +/- 30%. Future work will clarify the pros and cons of the two methods...

Peptide Assembly-Driven Metal-Organic Framework (MOF) Motors for Micro Electric Generator

Science.gov (United States)

Ikezoe, Yasuhiro; Fang, Justin; Wasik, Tomasz L.; Uemura, Takashi; Zheng, Yongtai; Kitagawa, Susumu

2014-01-01

Peptide-MOF motors, whose motions are driven by anisotropic surface gradients created via peptide self-assembly around nanopores of MOFs, can rotate microscopic rotors and magnet fast enough to generate electric power of 0.1 µW. To make the peptide-MOF generator recyclable, a new MOF is applied as a host motor engine, which has a more rigid framework with higher H2O affinity so that peptide release occurs more efficiently via guest exchange without the destruction of MOF. PMID:25418936

In vitro study of a new biodegradable nanocomposite based on poly propylene fumarate as bone glue

Energy Technology Data Exchange (ETDEWEB)

Shahbazi, S.; Moztarzadeh, F. [Department of Medical Engineering, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Sadeghi, G. Mir Mohamad [Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Jafari, Y., E-mail: y.j.arisman@gmail.com [Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan (Iran, Islamic Republic of)

2016-12-01

A novel poly propylene fumarate (PPF)-based glue which is reinforced by nanobioactive glass (NBG) particles and promoted by hydroxyethyl methacrylate (HEMA) as crosslinker agent, was developed and investigated for bone-to-bone bonding applications. In-vitro bioactivity, biodegradability, biocompatibility, and bone adhesion were tested and the results have verified that it can be used as bone glue. In an in-vitro condition, the prepared nanocomposite (PPF/HEMA/NBG) showed improved adhesion to wet bone surfaces. The combined tension and shear resistance between two wet bone surfaces was measured, and its maximum value was 9 ± 59 MPa. To investigate the bioactivity and biodegradability of the nanocomposite, it has been immersed in simulated body fluid (SBF). After 14 days exposure to SBF, a hydroxyapatite (HA) layer formed on the surface of the composite confirms the bioactivity of this material. In the XRD pattern of the nanocomposite surface, the HA characteristic diffraction peak at θ = 26 and 31.8 were observed. Also, by monitoring the weight change after 8 weeks immersion in SBF, the mass loss was about 16.46 wt%. It has been confirmed that this nanocomposite is a biodegradable material. Also, bioactivity and biodegradability of nanocomposite have been proved by SEM images. It has been showed that by using NBG particles and HEMA precursor, mechanical properties increased significantly. The ultimate tensile strength (UTS) of nanocomposite which contains 20% NBG and the ratio of 70/30 wt% PPF/HEMA (PHB.732) was approximately 62 MPa, while the UTS in the pure PPF/HEMA was about 32 MPa. High cell viability in this nanocomposite (MTT assays, 85–95%) can be attributed to the NBG nature which contains calcium phosphate and is similar to physiological environment. Furthermore, it possesses biomineralization and biodegradation which significantly affected by impregnation of hydrophilic HEMA in the PPF-based polymeric matrix. The results indicated that the new

ng: What next-generation languages can teach us about HENP frameworks in the manycore era

International Nuclear Information System (INIS)

Binet, Sébastien

2011-01-01

Current High Energy and Nuclear Physics (HENP) frameworks were written before multicore systems became widely deployed. A 'single-thread' execution model naturally emerged from that environment, however, this no longer fits into the processing model on the dawn of the manycore era. Although previous work focused on minimizing the changes to be applied to the LHC frameworks (because of the data taking phase) while still trying to reap the benefits of the parallel-enhanced CPU architectures, this paper explores what new languages could bring to the design of the next-generation frameworks. Parallel programming is still in an intensive phase of R and D and no silver bullet exists despite the 30+ years of literature on the subject. Yet, several parallel programming styles have emerged: actors, message passing, communicating sequential processes, task-based programming, data flow programming, ... to name a few. We present the work of the prototyping of a next-generation framework in new and expressive languages (python and Go) to investigate how code clarity and robustness are affected and what are the downsides of using languages younger than FORTRAN/C/C++.

Efficacy, Reliability, and Safety of Completely Autologous Fibrin Glue in Neurosurgical Procedures: Single-Center Retrospective Large-Number Case Study.

Science.gov (United States)

Nakayama, Noriyuki; Yano, Hirohito; Egashira, Yusuke; Enomoto, Yukiko; Ohe, Naoyuki; Kanemura, Nobuhiro; Kitagawa, Junichi; Iwama, Toru

2018-01-01

Commercially available fibrin glue (Com-FG), which is used commonly worldwide, is produced with pooled human plasma from multiple donors. However, it has added bovine aprotinin, which involves the risk of infection, allogenic immunity, and allergic reactions. We evaluate the efficacy, reliability, and safety of completely autologous fibrin glue (CAFG). From August 2014 to February 2016, prospective data were collected and analyzed from 153 patients. CAFG was prepared with the CryoSeal System using autologous blood and was applied during neurosurgical procedures. Using CAFG-soaked oxidized regenerated cellulose and/or polyglycolic acid sheets, we performed a pinpoint hemostasis, transposed the offending vessels in a microvascular decompression, and covered the dural incision to prevent cerebrospinal fluid leakage. The CryoSeal System had generated up to a mean of 4.51 mL (range, 3.0-8.4 mL) of CAFG from 400 mL autologous blood. Com-FG products were not used in our procedures. Only 6 patients required an additional allogeneic blood transfusion. The hemostatic effective rate was 96.1% (147 of 153 patients). Only 1 patient who received transsphenoidal surgery for a pituitary adenoma presented with the complication of delayed postoperative cerebrospinal fluid leakage (0.65%). No patient developed allergic reactions or systemic complications associated with the use of CAFG. CAFG effectively provides hemostatic, adhesive, and safety performance. The timing and three-dimensional shape of CAFG-soaked oxidized regenerated cellulose and/or polyglycolic acid sheets solidification can be controlled with slow fibrin formation. The cost to prepare CAFG is similar compared with Com-FG products, and it can therefore be easily used at most institutions. Copyright © 2017 Elsevier Inc. All rights reserved.

An optimization framework for the integrated planning of generation and transmission expansion in interconnected power systems

International Nuclear Information System (INIS)

Guerra, Omar J.; Tejada, Diego A.; Reklaitis, Gintaras V.

2016-01-01

Highlights: • A novel optimization framework for the design and planning of interconnected power systems is proposed. • The framework integrates generation and transmission capacity expansion planning. • Reserve and emission constraints are included. • Business as usual and CO_2 mitigation policy scenarios are evaluated. • Reconfiguration of existing power generation technologies is the most cost-effective option for CO_2 emissions mitigation. - Abstract: Energy, and particularly electricity, has played and will continue to play a very important role in the development of human society. Electricity, which is the most flexible and manageable energy form, is currently used in a variety of activities and applications. For instance, electricity is used for heating, cooling, lighting, and for operating electronic appliances and electric vehicles. Nowadays, given the rapid development and commercialization of technologies and devices that rely on electricity, electricity demand is increasing faster than overall primary energy supply. Consequently, the design and planning of power systems is becoming a progressively more important issue in order to provide affordable, reliable and sustainable energy in timely fashion, not only in developed countries but particularly in developing economies where electricity demand is increasing even faster. Power systems are networks of electrical devices, such as power plants, transformers, and transmission lines, used to produce, transmit, and supply electricity. The design and planning of such systems require the selection of generation technologies, along with the capacity, location, and timing of generation and transmission capacity expansions to meet electricity demand over a long-term horizon. This manuscript presents a comprehensive optimization framework for the design and planning of interconnected power systems, including the integration of generation and transmission capacity expansion planning. The proposed

A framework for smartphone-enabled, patient-generated health data analysis

Directory of Open Access Journals (Sweden)

Shreya S. Gollamudi

2016-08-01

Full Text Available Background: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously conducted a six-month interventional trial examining the efficacy of a comprehensive smartphone-based health monitoring program for individuals with chronic disease. This included 38 individuals with hypertension who recorded 6,290 blood pressure readings over the trial. Methods: In the present study, we provide a hypothesis testing framework for unstructured time series data, typical of patient-generated mobile device data. We used a mixed model approach for unequally spaced repeated measures using autoregressive and generalized autoregressive models, and applied this to the blood pressure data generated in this trial. Results: We were able to detect, roughly, a 2 mmHg decrease in both systolic and diastolic blood pressure over the course of the trial despite considerable intra- and inter-individual variation. Furthermore, by supplementing this finding by using a sequential analysis approach, we observed this result over three months prior to the official study end—highlighting the effectiveness of leveraging the digital nature of this data source to form timely conclusions. Conclusions: Health data generated through the use of smartphones and other mobile devices allow individuals the opportunity to make informed health decisions, and provide researchers the opportunity to address innovative health and biology questions. The hypothesis testing framework we present can be applied in future studies utilizing digital medicine technology or implemented in the technology itself to support the quantified self.

Identification and quantification of glue-like off-odors in elastic therapeutic tapes.

Science.gov (United States)

Denk, Philipp; Buettner, Andrea

2018-05-01

Elastic therapeutic tapes are an important tool in the field of physical therapy and medicine. These tapes contain types of adhesive. However, sensory evaluations revealed the release of pronounced and irritating odors of the tapes. Negative odors were, amongst others, reported in elastic therapeutic tapes containing acrylic adhesives. In this study, the odor of four different tape samples was evaluated applying a descriptive analysis approach carried out by a trained sensory panel. Afterwards, the volatile compounds were recovered from the samples by solvent extraction and isolated by solvent-assisted flavor evaporation (SAFE). The obtained distillates were subsequently analyzed by gas chromatography-olfactometry (GC-O) and two-dimensional GC-O coupled with mass spectrometry (2D-GC-MS/O). To determine the most potent odorants in the distillates, odor extract dilution analyses (OEDA) were carried out. Thirty-one odorants were successfully identified using this approach, which were all described for the first time as odorants in tapes. Amongst the set of volatiles, unsaturated and saturated aldehydes were present, eliciting fatty, soapy, and citrus-like odor impressions, as well as a range of glue-like, moldy, and fruity smelling odor-active volatiles, such as 2-ethyl-1-hexanol, butyl benzoate, and 3-phenyltoluene. Based on their relative intensities, the concentrations of the glue-like smelling substances were determined: 2-ethyl-1-hexanol, present in all samples, was determined with concentrations ranging from 10 to 200 mg/kg in the investigated tapes.

Bulk physicochemical, interconnectivity, and mechanical properties of calcium phosphate cements-fibrin glue composites for bone substitute applications

NARCIS (Netherlands)

Lopez-Heredia, M.A.; Pattipeilohy, J.; Hsu, S.; Grykien, M.; Weijden, B. van der; Leeuwenburgh, S.C.G.; Salmon, P.; Wolke, J.G.C.; Jansen, J.A.

2013-01-01

Calcium phosphate cements (CPCs) and fibrin glue (FG) are used for surgical applications. Their combination is promising to create bone substitutes able to promote cell attachment and bone remodeling. This study proposes a novel approach to create CPC-FG composites by simultaneous CPC setting and FG

Tailored motivational message generation: A model and practical framework for real-time physical activity coaching.

Science.gov (United States)

Op den Akker, Harm; Cabrita, Miriam; Op den Akker, Rieks; Jones, Valerie M; Hermens, Hermie J

2015-06-01

This paper presents a comprehensive and practical framework for automatic generation of real-time tailored messages in behavior change applications. Basic aspects of motivational messages are time, intention, content and presentation. Tailoring of messages to the individual user may involve all aspects of communication. A linear modular system is presented for generating such messages. It is explained how properties of user and context are taken into account in each of the modules of the system and how they affect the linguistic presentation of the generated messages. The model of motivational messages presented is based on an analysis of existing literature as well as the analysis of a corpus of motivational messages used in previous studies. The model extends existing 'ontology-based' approaches to message generation for real-time coaching systems found in the literature. Practical examples are given on how simple tailoring rules can be implemented throughout the various stages of the framework. Such examples can guide further research by clarifying what it means to use e.g. user targeting to tailor a message. As primary example we look at the issue of promoting daily physical activity. Future work is pointed out in applying the present model and framework, defining efficient ways of evaluating individual tailoring components, and improving effectiveness through the creation of accurate and complete user- and context models. Copyright © 2015 Elsevier Inc. All rights reserved.

Geometry effect on the behaviour of single and glue-laminated glass fibre reinforced polymer composite sandwich beams loaded in four-point bending

International Nuclear Information System (INIS)

Awad, Ziad K.; Aravinthan, Thiru; Manalo, Allan

2012-01-01

Highlights: ► Investigated the behaviour of single and glue-laminated GFRP sandwich beam. ► Effect of shear span to depth was a key factor affecting the overall behaviour. ► Comparison with prediction models gave reasonable results in specific regions. ► A failure map was developed to identify the shear and flexural failures of panels. -- Abstract: The research investigated the behaviour of single and glue laminated glass fibre reinforced polymer (GFRP) composite sandwich beams considering different spans and beam cross sections. The composite sandwich beams with different thicknesses (1, 2, 3, 4, and 5 sandwich layers) have been tested in four-point static flexural test with different shear span to depth ratio (a/d). The a/d ratios showed a direct effect on the flexural and shear behaviour. The capacity of the beam decreased with increasing a/d. Various failure modes were observed including core crushing, core shear, and top skin compression failure. The failure mode map developed based on the experimental finding and analytical prediction indicated that the failure mode is affected by the a/d with the number of glue laminated panels.

Successful management with glue injection of arterial rupture seen during embolization of an arteriovenous malformation using a flow-directed catheter: a case report

Energy Technology Data Exchange (ETDEWEB)

Hong, Jong Won; Baik, Seung Kug; Shin, Mi Jung; Choi, Han Yong; Kim, Bong Gi [Wallace Memorial Baptist Hospital, Pusan (Korea, Republic of)

2000-12-01

We present a case in which an arterial rupture occurring during embolization of an arteriovenous malformation of the left occipital lobe with a flow-directed micro-catheter, was successfully sealed with a small amount of glue. We navigated a 1.8-Fr Magic catheter through the posterior cerebral artery, and during superselective test injection, extravasation was observed at the parieto-occipital branch. The catheter was not removed and the perforation site was successfully sealed with a small amount of glue injected through the same catheter. Prompt recognition and closure of the perforation site is essential for good prognosis. (author)

Beam asymmetry Σ for π0 and η photoproduction on the proton at GlueX

Science.gov (United States)

Zhang, Zhenyu; GlueX Collaboration

2016-09-01

Measurements of meson photoproduction at high energies began almost 50 years ago with bubble chamber experiments at SLAC, DESY, and Cambridge. These data have been successfully described through Regge theory in terms of t-channel quasi-particle exchange. High statistics measurements of pseudoscalar meson photoproduction at GlueX, using the 9 GeV linearly-polarized, tagged photon beam in Jefferson Lab's Hall D, will provide important new constraints on these Regge models. These measurements will test our understanding of the photoproduction mechanism at high energy, which is a necessary first step toward the broader meson spectroscopy program at GlueX. Through finite energy sum rules, these measurements can also impose new constraints on the extraction of nucleon resonances from low energy photoproduction data. In this talk, preliminary results for the linearly polarized photon beam asymmetry Σ for the exclusive reactions γp -> pπ0 and γp -> pη will be presented. These are the first measurements of the η beam asymmetry at these energies. Supported by Jefferson Science Associates, LLC under U.S. DOE Contract No. DE-AC05-06OR23177 and the China Scholarship Council No. 201506275156.

Automatic Model Generation Framework for Computational Simulation of Cochlear Implantation.

Science.gov (United States)

Mangado, Nerea; Ceresa, Mario; Duchateau, Nicolas; Kjer, Hans Martin; Vera, Sergio; Dejea Velardo, Hector; Mistrik, Pavel; Paulsen, Rasmus R; Fagertun, Jens; Noailly, Jérôme; Piella, Gemma; González Ballester, Miguel Ángel

2016-08-01

Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging. To address such a challenge, we propose an automatic framework for the generation of patient-specific meshes for finite element modeling of the implanted cochlea. First, a statistical shape model is constructed from high-resolution anatomical μCT images. Then, by fitting the statistical model to a patient's CT image, an accurate model of the patient-specific cochlea anatomy is obtained. An algorithm based on the parallel transport frame is employed to perform the virtual insertion of the cochlear implant. Our automatic framework also incorporates the surrounding bone and nerve fibers and assigns constitutive parameters to all components of the finite element model. This model can then be used to study in silico the effects of the electrical stimulation of the cochlear implant. Results are shown on a total of 25 models of patients. In all cases, a final mesh suitable for finite element simulations was obtained, in an average time of 94 s. The framework has proven to be fast and robust, and is promising for a detailed prognosis of the cochlear implantation surgery.

Percutaneous sclerotherapy of massive macrocystic lymphatic malformations of the face and neck using fibrin glue with OK-432 and bleomycin.

Science.gov (United States)

Chen, W-l; Huang, Z-q; Chai, Q; Zhang, D-m; Wang, Y-y; Wang, H-j; Wang, L; Fan, S

2011-06-01

Picibanil (OK-432) and bleomycin have been used as alternative sclerosing agents for lymphatic malformations. This study evaluated the clinical curative effect of sclerotherapy using fibrin glue combined with OK-432 and bleomycin for the treatment of macrocystic lymphatic malformations of the face and neck. Fifteen paediatric patients (6 males; 9 females, aged 13 months to 14 years) who had received percutaneous sclerotherapy for massive macrocystic lymphatic malformations of the face and neck were retrospectively reviewed. Affected regions included the neck, parotid region and parapharynx, mouth floor, face and cheek, and orbital regions. All patients showed preoperative symptoms of space-occupying lesions between 4 cm × 5 cm and 12 cm × 16 cm in size. Fibrin glue with OK-432 and bleomycin was injected under general anaesthesia. All patients received preoperative and follow-up CT scans. Outcomes were assessed by three surgeons. All patients exhibited mid-facial swelling for 3-4 weeks after surgery, but no major complications. Follow-up periods ranged from 8 to 16 months. Eight lesions were completely involuted, five were mostly involuted, and two were partially involuted. Percutaneous sclerotherapy using fibrin glue with OK-432 and bleomycin provided a simple, safe, and reliable alternative treatment for massive macrocystic lymphatic malformations of the face and neck. Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Preoperative embolization of nasopharyngeal angiofibromas: The role of direct percutaneous injection of cyanoacrylate glue in conjunction with particulate endovascular approach

Directory of Open Access Journals (Sweden)

Mohamed Abdel Hakim Osman Kasem

2016-12-01

Conclusion: The embolization of nasopharyngeal angiofibromas before surgery using percutaneous cyanoacrylate glue with endovascular particulate material proved to efficiently devascularize these tumours with lower blood loss during surgery and no major procedural complications.

COMDES-II: A Component-Based Framework for Generative Development of Distributed Real-Time Control Systems

DEFF Research Database (Denmark)

Ke, Xu; Sierszecki, Krzysztof; Angelov, Christo K.

2007-01-01

The paper presents a generative development methodology and component models of COMDES-II, a component-based software framework for distributed embedded control systems with real-time constraints. The adopted methodology allows for rapid modeling and validation of control software at a higher lev...... methodology for COMDES-II from a general perspective, describes the component models in details and demonstrates their application through a DC-Motor control system case study.......The paper presents a generative development methodology and component models of COMDES-II, a component-based software framework for distributed embedded control systems with real-time constraints. The adopted methodology allows for rapid modeling and validation of control software at a higher level...

Pancreatic fistula after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis: effect of fibrin glue and polyglycolic acid felt on prophylaxis of postoperative complications.

Science.gov (United States)

Tsutsumi, Norifumi; Tomikawa, Morimasa; Akahoshi, Tomohiko; Kawanaka, Hirofumi; Ota, Mitsuhiko; Sakaguchi, Yoshihisa; Kusumoto, Tetsuya; Ikejiri, Koji; Hashizume, Makoto; Maehara, Yoshihiko

2016-11-01

This study aimed to determine the effect of fibrin glue and polyglycolic acid (PGA) felt on prevention of pancreatic fistula (PF) after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis. Fifty consecutive patients were enrolled in this prospective study. Twenty-three patients underwent laparoscopic splenectomy with a fibrin sheet (fibrin sheet group). The sealing ability of each treatment was evaluated by an ex vivo pressure test model. Based on the results from ex vivo experiments, 27 patients received prophylaxis using fibrin glue and PGA felt (PGA with fibrin group). The primary endpoint was the incidence of PF. Significantly more (5, 22%) patients developed PF in the fibrin sheet group than in the PGA with fibrin group (0%, P = .037). Our new application of fibrin glue and PGA felt is an effective prophylactic procedure for preventing development of PF after laparoscopic splenectomy. Copyright © 2016 Elsevier Inc. All rights reserved.

TRANS-ARTERIAL EMBOLIZATION WITH N-BUTYL CYANOACRYLATE GLUE FOR RENAL BLEEDING: Case Report

Directory of Open Access Journals (Sweden)

Benny Young

2014-08-01

Full Text Available Background: The objectivity in management of renal bleeding is to preserve a significant renal parenchyma tissue and prevent associated morbidities like anemic shock or renal impairment from substantial nephron demise or obstructed uropathy. Trans-arterial embolization therapy by interventional radiology offers a high success rate with potential of reserving normal renal tissue. The selection material for renal arterial embolization largely depends on vasculature anatomy and end-point of procedure. N-butyl cyanoacrylate glue in our experience is applied in lesion supplied by small size of end-artery. 

N-butyl Cyanoacrylate Glue Embolization of Arterial Networks to Facilitate Hepatic Arterial Skeletonization before Radioembolization

Energy Technology Data Exchange (ETDEWEB)

Samuelson, Shaun D.; Louie, John D.; Sze, Daniel Y., E-mail: dansze@stanford.edu [Stanford University School of Medicine, Division of Interventional Radiology (United States)

2013-06-15

Purpose. Avoidance of nontarget microsphere deposition via hepatoenteric anastomoses is essential to the safety of yttrium-90 radioembolization (RE). The hepatic hilar arterial network may remain partially patent after coil embolization of major arteries, resulting in persistent risk. We retrospectively reviewed cases where n-butyl cyanoacrylate (n-BCA) glue embolization was used to facilitate endovascular hepatic arterial skeletonization before RE. Methods. A total of 543 RE procedures performed between June 2004 and March 2012 were reviewed, and 10 were identified where n-BCA was used to embolize hepatoenteric anastomoses. Arterial anatomy, prior coil embolization, and technical details were recorded. Outcomes were reviewed to identify subsequent complications of n-BCA embolization or nontarget RE. Results. The rate of complete technical success was 80 % and partial success 20 %, with one nontarget embolization complication resulting in a minor change in treatment plan. No evidence of gastrointestinal or biliary ischemia or infarction was identified, and no microsphere-related gastroduodenal ulcerations or other evidence of nontarget RE were seen. Median volume of n-BCA used was <0.1 ml. Conclusion. n-BCA glue embolization is useful to eliminate hepatoenteric networks that may result in nontarget RE, especially in those that persist after coil embolization of major vessels such as the gastroduodenal and right gastric arteries.

A framework to describe, analyze and generate interactive motor behaviors.

Directory of Open Access Journals (Sweden)

Nathanaël Jarrassé

Full Text Available While motor interaction between a robot and a human, or between humans, has important implications for society as well as promising applications, little research has been devoted to its investigation. In particular, it is important to understand the different ways two agents can interact and generate suitable interactive behaviors. Towards this end, this paper introduces a framework for the description and implementation of interactive behaviors of two agents performing a joint motor task. A taxonomy of interactive behaviors is introduced, which can classify tasks and cost functions that represent the way each agent interacts. The role of an agent interacting during a motor task can be directly explained from the cost function this agent is minimizing and the task constraints. The novel framework is used to interpret and classify previous works on human-robot motor interaction. Its implementation power is demonstrated by simulating representative interactions of two humans. It also enables us to interpret and explain the role distribution and switching between roles when performing joint motor tasks.

Experimental Status of Exotic Mesons and the GlueX Experiment

Energy Technology Data Exchange (ETDEWEB)

Daniel Carman

2006-10-22

One of the unanswered and most fundamental questions in physics regards the nature of the confinement mechanism of quarks and gluons in QCD. Exotic hybrid mesons manifest gluonic degrees of freedom and their spectroscopy will provide the data necessary to test assumptions in lattice QCD and the specific phenomenology leading to confinement. Within the past two decades a number of experiments have put forth tantalizing evidence for the existence of exotic hybrid mesons in the mass range below 2 GeV. This talk represents an overview of the available data and what has been learned. In looking toward the future, the GlueX experiment at Jefferson Laboratory represents a new initiative that will perform detailed spectroscopy of the light-quark meson spectrum. This experiment and its capabilities will be reviewed.

Measurement framework for product service system performance of generator set distributors

Science.gov (United States)

Sofianti, Tanika D.

2017-11-01

Selling Generator Set (Genset) in B2B market, distributors assisted manufacturers to sell products. This is caused by the limited resources owned by the manufacturer for adding service elements. These service elements are needed to enhance the competitiveness of the generator sets. Some genset distributors often sell products together with supports to their customers. Industrial distributor develops services to meet the needs of the customer. Generator set distributors support machines and equipment produced by manufacturer. The services delivered by the distributors could enhance value obtained by the customers from the equipment. Services provided to customers in bidding process, ordering process of the equipment from the manufacturer, equipment delivery, installations, and the after sales stage. This paper promotes framework to measure Product Service System (PSS) of Generator Set distributors in delivering their products and services for the customers. The methodology of conducting this research is by adopting the perspective of the providers and customers and by taking into account the tangible and intangible products. This research leads to the idea of improvement of current Product Service System of a Genset distributor. This research needs further studies in more detailed measures and the implementation of measurement tools.

GLUE Analysis and Optimal Operation for Diyala River Basin in Iraq Using Variable Infiltration Capacity Model

Science.gov (United States)

Waheed, S., Sr.; Ramirez, J.

2017-12-01

Uncertainty in both hydrologic behavior and model characterization is a concern for current and future water resource system planning, operation, and management. To develop optimal dam operation schemes under future uncertainty, the sensitivity of the precipitation-runoff response to changes in hydro-climatic forcing must be quantified. To achieve this purpose, accurate (observational and modeled) data should be implemented. Herein, many data sources were compared to representative hydrologic datasets. Due to limited availability of observed daily data, a random temporal cascade method was used to downscale the monthly precipitation into daily. Then, four interpolation methods were compared to transform the point into gridded data. Furthermore, a regression technique coupled with Kriging method was developed. The method is based on regressing modeled data (from VIC dataset) with the observed gridded temperature by relating the regression to the geometry of each grid. The sensitivity and identifiability of the Variable Infiltration Capacity model (VIC) for the Diyala River basin in Iraq were evaluated using GLUE technique. Diyala River is a Tigris River tributary in eastern Iraq. Its total length and basin area are about 216.5 km and 16,763.7 km2, respectively. Seven candidate parameters of VIC model (b_infilt, Ds, Ws, Dsmax, and depths of soil layer 1, 2, and 3) associated with the infiltration and surface runoff production processes are examined for 14000 random sets. The comparison between the different data showed that neither the observations from Tropical Rainfall Measurement Mission nor the VIC modeled data is accurate for gridded precipitation; therefore, a downscaling technique was applied. Moreover, the comparison between four different interpolation techniques revealed that the Kriging method is the most accurate. The optimal model performance was found to be 0.731 NSCE. Also, the GLUE analysis results implied that the depth of the second soil layer depth

Evaluating Uncertainty of Runoff Simulation using SWAT model of the Feilaixia Watershed in China Based on the GLUE Method

Science.gov (United States)

Chen, X.; Huang, G.

2017-12-01

In recent years, distributed hydrological models have been widely used in storm water management, water resources protection and so on. Therefore, how to evaluate the uncertainty of the model reasonably and efficiently becomes a hot topic today. In this paper, the soil and water assessment tool (SWAT) model is constructed for the study area of China's Feilaixia watershed, and the uncertainty of the runoff simulation is analyzed by GLUE method deeply. Taking the initial parameter range of GLUE method as the research core, the influence of different initial parameter ranges on model uncertainty is studied. In this paper, two sets of parameter ranges are chosen as the object of study, the first one (range 1) is recommended by SWAT-CUP and the second one (range 2) is calibrated by SUFI-2. The results showed that under the same number of simulations (10,000 times), the overall uncertainty obtained by the range 2 is less than the range 1. Specifically, the "behavioral" parameter sets for the range 2 is 10000 and for the range 1 is 4448. In the calibration and the validation, the ratio of P-factor to R-factor for range 1 is 1.387 and 1.391, and for range 2 is 1.405 and 1.462 respectively. In addition, the simulation result of range 2 is better with the NS and R2 slightly higher than range 1. Therefore, it can be concluded that using the parameter range calibrated by SUFI-2 as the initial parameter range for the GLUE is a way to effectively capture and evaluate the simulation uncertainty.

Statistical framework for detection of genetically modified organisms based on Next Generation Sequencing.

Science.gov (United States)

Willems, Sander; Fraiture, Marie-Alice; Deforce, Dieter; De Keersmaecker, Sigrid C J; De Loose, Marc; Ruttink, Tom; Herman, Philippe; Van Nieuwerburgh, Filip; Roosens, Nancy

2016-02-01

Because the number and diversity of genetically modified (GM) crops has significantly increased, their analysis based on real-time PCR (qPCR) methods is becoming increasingly complex and laborious. While several pioneers already investigated Next Generation Sequencing (NGS) as an alternative to qPCR, its practical use has not been assessed for routine analysis. In this study a statistical framework was developed to predict the number of NGS reads needed to detect transgene sequences, to prove their integration into the host genome and to identify the specific transgene event in a sample with known composition. This framework was validated by applying it to experimental data from food matrices composed of pure GM rice, processed GM rice (noodles) or a 10% GM/non-GM rice mixture, revealing some influential factors. Finally, feasibility of NGS for routine analysis of GM crops was investigated by applying the framework to samples commonly encountered in routine analysis of GM crops. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

A Framework for Evaluation of Safety and Generation Effect of Investment Considering Life Cycle Management in Nuclear Power Plants

International Nuclear Information System (INIS)

Yang, Hui Chang; Kim, Joon Hyun; Ahn, Nam Sung

2006-01-01

Along with the increasing pressure to enhance generation availability with low cost or investment, regulatory organization has been focused on the enhancement of safety in performance-based and risk informed regulation framework. Considering this, the most cost-beneficial solution should be found among the short-term and long-term investment plans. The objective of this research is to propose a generalized framework to evaluate safety and generation effect of investment plan for equipment in nuclear power plants

A Framework for Privacy-preserving Classification of Next-generation PHR data.

Science.gov (United States)

Koufi, Vassiliki; Malamateniou, Flora; Prentza, Andriana; Vassilacopoulos, George

2014-01-01

Personal Health Records (PHRs), integrated with data from various sources, such as social care data, Electronic Health Record data and genetic information, are envisaged as having a pivotal role in transforming healthcare. These data, lumped under the term 'big data', are usually complex, noisy, heterogeneous, longitudinal and voluminous thus prohibiting their meaningful use by clinicians. Deriving value from these data requires the utilization of innovative data analysis techniques, which, however, may be hindered due to potential security and privacy breaches that may arise from improper release of personal health information. This paper presents a HIPAA-compliant machine learning framework that enables privacy-preserving classification of next-generation PHR data. The predictive models acquired can act as supporting tools to clinical practice by enabling more effective prevention, diagnosis and treatment of new incidents. The proposed framework has a huge potential for complementing medical staff expertise as it outperforms the manual inspection of PHR data while protecting patient privacy.

Pain experience during internal spermatic vein embolization for varicocele: comparison of two cyanoacrylate glues

Energy Technology Data Exchange (ETDEWEB)

Heye, Sam; Maleux, Geert; Wilms, Guido [University Hospital Gasthuisberg, Department of Radiology, Leuven (Belgium)

2006-01-01

The purpose of this study was to evaluate possible pain sensation differences in patients after retrograde varicocele embolization either with n-butyl-(2)-cyanoacrylate (NBCA) or with n-butyl-(2)-cyanoacrylate + methacryloxysulfolane (NBCA-MS). Transcatheter varicocele embolization was performed in 64 consecutive patients (62 left, two bilateral). Embolization was done with NBCA (n=32) or NBCA-MS (n=32). Immediately after the procedure, patients were asked to evaluate pain during embolization using a visual analog scale (VAS). Statistical analysis was done with Student's t test. Mean pain score on VAS was 3.23 (range: 0-8) for NBCA and 3.28 (range 0-9) for NBCA-MS. This difference was not significant (P=0.932). Independently of the type of glue, no difference in pain sensation (P value 0.421) was found between patients younger than 18 (n=29) and patients older than 18 years of age (n=35) (younger than18, mean 3.52; older than 18, mean 3.05). No difference in mean pain experience level (P=0.323) was seen in 11 patients with vessel wall perforation (23.4%) during the procedure (3.89; range: 0-8.5) in comparison with those without perforation (mean pain sensation level: 3.13; range: 0-9). No difference in pain experience was found after transcatheter varicocele embolization either with NBCA or NBCA-MS. Age and vessel wall perforation have no influence on pain sensation independently of the type of glue. (orig.)

Pain experience during internal spermatic vein embolization for varicocele: comparison of two cyanoacrylate glues

International Nuclear Information System (INIS)

Heye, Sam; Maleux, Geert; Wilms, Guido

2006-01-01

The purpose of this study was to evaluate possible pain sensation differences in patients after retrograde varicocele embolization either with n-butyl-(2)-cyanoacrylate (NBCA) or with n-butyl-(2)-cyanoacrylate + methacryloxysulfolane (NBCA-MS). Transcatheter varicocele embolization was performed in 64 consecutive patients (62 left, two bilateral). Embolization was done with NBCA (n=32) or NBCA-MS (n=32). Immediately after the procedure, patients were asked to evaluate pain during embolization using a visual analog scale (VAS). Statistical analysis was done with Student's t test. Mean pain score on VAS was 3.23 (range: 0-8) for NBCA and 3.28 (range 0-9) for NBCA-MS. This difference was not significant (P=0.932). Independently of the type of glue, no difference in pain sensation (P value 0.421) was found between patients younger than 18 (n=29) and patients older than 18 years of age (n=35) (younger than18, mean 3.52; older than 18, mean 3.05). No difference in mean pain experience level (P=0.323) was seen in 11 patients with vessel wall perforation (23.4%) during the procedure (3.89; range: 0-8.5) in comparison with those without perforation (mean pain sensation level: 3.13; range: 0-9). No difference in pain experience was found after transcatheter varicocele embolization either with NBCA or NBCA-MS. Age and vessel wall perforation have no influence on pain sensation independently of the type of glue. (orig.)

The GlueX Start Counter and Beam Asymmetry$\\Sigma$ in Single $\\pi^{0}$ Photoproduction

Energy Technology Data Exchange (ETDEWEB)

Pooser, Eric [Florida Intl Univ., Miami, FL (United States)

2016-03-26

The GlueX experiment aims to study meson photoproduction while utilizing the coherent bremsstrahlung technique to produce a 9 GeV linearly polarized photon beam incident on a liquid H₂ target. A Start Counter detector was fabricated to properly identify the accelerator electron beam buckets and to provide accurate timing information. The Start Counter detector was designed to operate at photon intensities of up to 10⁸ γ/s in the coherent peak and provides a timing resolution ~300 ps so as to provide successful identification of the electron beam buckets to within 99% accuracy. Furthermore, the Start Counter detector provides excellent solid angle coverage, ~ 90% of 4π hermeticity, and a high degree of segmentation for background rejection. It consists of a cylindrical array of 30 scintillators with pointed ends that bend towards the beam at the downstream end. Magnetic field insensitive silicon photomultiplier detectors were selected as the readout system. An initial measurement of the beam asymmetry Sigma in the exclusive reaction γ$\\vec{p}$→ π⁰p, where π⁰ → γ has been carried out utilizing the GlueX spectrometer during the Spring 2015 commissioning run. The tagged photon energies ranged from 2.5≤ Eγ ≤ 3.0 GeV in the coherent peak. These measurements were then compared to the world data set and show remarkable agreement with only two hours of physics production running.

An IP Framework for the Crew Pairing Problem Using Subsequence Generation

DEFF Research Database (Denmark)

Rasmussen, Matias Sevel; Lusby, Richard Martin; Ryan, David

In this paper we consider an important problem for the airline industry. The widely studied crew pairing problem is typically formulated as a set partitioning problem and solved using the branch-and-price methodology. Here we develop a new integer programming framework, based on the concept...... of subsequence generation, for solving the set partitioning formulation. In subsequence generation one restricts the number of permitted subsequent flights, that a crew member can turn to after completing any particular flight. By restricting the number of subsequences, the number of pairings in the problem...... decreases. The aim is then to dynamically add attractive subsequences to the problem, thereby increasing the number of possible pairings and improving the solution quality. Encouraging results are obtained on 19 real-life instances supplied by Air New Zealand and show that the described methodology...

A comparative in vitro study of the viability of human keratinocytes grown on irradiated human amnion membrane and fibrin glue scaffolds

International Nuclear Information System (INIS)

Dorai, A.A.; Lim, C.K.; Azman, W.S.; Halim, A.S.

2008-01-01

Full text: The dried irradiated human amnion membrane has been used as a biological dressing for various clinical conditions. Being another biological membrane its potential as a scaffold to grow human keratinocytes is not known yet. To compare the growth patterns and cell viability of keratinocytes using fibrin glue and air dried amnion membrane as a scaffold. Keratinocytes were obtained from skin samples of six patients undergoing elective surgery. Fibrin glue (Tisseel, Baxter ) was diluted and used to coat the wells. Human dried amnion membrane was obtained and placed into the 24 well plates. Keratinocytes were seeded into the fibrin and amnion scaffold. Cell viability assay (MTT) was performed after 24, 48 and 72 hours. Finally the measurements were done by the Enzyme-Linked Immunosorbent Assay (ELISA) reader at 570 nm. Six patients consented for the study. The cells growing on the amnion scaffold showed a decreasing trend (20.67%, 17.94% and 16.78% respectively for 24, 48 and 72 hours). The cells growing on the fibrin scaffold showed a steady increase in number at 24, 48 and 72 hours (73.03%, 74.12% and 79.66%). The percentage of growth of normal human keratinocytes were significantly greater in the fibrin scaffold group (Mann - Whitney p = 0.002) for 24, 48 and 72 hours. The air dried irradiated human amnion membrane can be used as a scaffold to grow keratinocytes but however the growth pattern does not sustain with time. Fibrin glue supports the growth of human keratinocytes and shows an increasing pattern of growth with time. (Author)

Sherlock: A Semi-automatic Framework for Quiz Generation Using a Hybrid Semantic Similarity Measure.

Science.gov (United States)

Lin, Chenghua; Liu, Dong; Pang, Wei; Wang, Zhe

In this paper, we present a semi-automatic system (Sherlock) for quiz generation using linked data and textual descriptions of RDF resources. Sherlock is distinguished from existing quiz generation systems in its generic framework for domain-independent quiz generation as well as in the ability of controlling the difficulty level of the generated quizzes. Difficulty scaling is non-trivial, and it is fundamentally related to cognitive science. We approach the problem with a new angle by perceiving the level of knowledge difficulty as a similarity measure problem and propose a novel hybrid semantic similarity measure using linked data. Extensive experiments show that the proposed semantic similarity measure outperforms four strong baselines with more than 47 % gain in clustering accuracy. In addition, we discovered in the human quiz test that the model accuracy indeed shows a strong correlation with the pairwise quiz similarity.

Autologous plasma rich in growth factors in the prevention of severe bleeding after teeth extractions in patients with bleeding disorders: a controlled comparison with fibrin glue

Science.gov (United States)

Cocero, Nadia; Pucci, Fabrizio; Messina, Maria; Pollio, Berardino; Mozzati, Marco; Bergamasco, Laura

2015-01-01

Background Dental extractions in haemophiliacs may cause secondary bleeding, requiring repeated surgical and haematological interventions. As a local haemostatic, fibrin glue has recognised efficacy but, as a plasma-derived product, it carries the risk of viral infections. We, therefore, compared fibrin glue with an autologous haemostatic, plasma rich in growth factors (PRGF), in a controlled trial. Material and methods One hundred and twenty patients with different blood disorders were randomised into two cohorts to undergo dental extraction procedures without hospitalisation. Prior to the extractions, patients underwent systemic haematological treatment. Complications were defined as secondary bleeding after the 7-day follow-up period or protracting after the repair procedure. Results There were 106 extractions (7 retained 3rd molars) in the group managed with fibrin glue: secondary bleeding affected 3/60 patients (5%) on the third day after extraction and necessitated additional surgery and systemic treatment (in one case the procedure had to be repeated on the 7th day). In the PRGF arm there were 98 extractions (23 retained 3rd molars): secondary bleeding affected two patients (3.3%) on the first day after extraction and was arrested with surgery without systemic treatment. Four out of the five secondary bleeds occurred in patients with haemophilia A. Concomitant diabetes or liver disease significantly increased the bleeding risk. Discussion The bleeding rates in the study and control arm prove that PRGF works as well as fibrin glue as a local haemostatic. Further assets are that PRGF has autologous origin, does not require additional systemic treatment in post-extraction repair surgery, is associated with an earlier onset of neo-angiogenesis and, overall, can reduce patients’ distress and costs to the health system. PMID:25369587

Highly Stretchable, Biocompatible, Striated Substrate Made from Fugitive Glue

Directory of Open Access Journals (Sweden)

Wei Li

2015-06-01

Full Text Available We developed a novel substrate made from fugitive glue (styrenic block copolymer that can be used to analyze the effects of large strains on biological samples. The substrate has the following attributes: (1 It is easy to make from inexpensive components; (2 It is transparent and can be used in optical microscopy; (3 It is extremely stretchable as it can be stretched up to 700% strain; (4 It can be micro-molded, for example we created micro-ridges that are 6 μm high and 13 μm wide; (5 It is adhesive to biological fibers (we tested fibrin fibers, and can be used to uniformly stretch those fibers; (6 It is non-toxic to cells (we tested human mammary epithelial cells; (7 It can tolerate various salt concentrations up to 5 M NaCl and low (pH 0 and high (pH 14 pH values. Stretching of this extraordinary stretchable substrate is relatively uniform and thus, can be used to test multiple cells or fibers in parallel under the same conditions.

Management of a complicated pulmonary fistula caused by lung cancer using a fibrin glue-soaked polyglycolic acid sheet covered with an intercostal muscle flap.

Science.gov (United States)

Maniwa, Tomohiro; Kaneda, Hiroyuki; Saito, Yukihito

2009-06-01

Pulmonary fistulas caused by tumours are very fragile and difficult to suture directly. It is impossible to close pulmonary fistulas with tissue sealants when massive air leakage occurs in the low pressure of the respiratory tract. A 73-year-old man with a pneumothorax caused by lung cancer had suffered a persistent massive air leakage for more than one month. We used a fibrin glue-soaked polyglycolic acid (PGA) sheet for sealing the complicated fistula. In addition, the visceral pleura of the fistula was wrapped with the pedicle of an intercostal muscle (ICM) flap to prevent massive air leakage. The pneumothorax did not reappear after surgery. Thus, a fibrin glue-soaked PGA sheet covered with an ICM flap was effective for sealing an intractable air-leaking fistula caused by lung cancer.

From glue to gasoline: how competition turns perspective takers unethical.

Science.gov (United States)

Pierce, Jason R; Kilduff, Gavin J; Galinsky, Adam D; Sivanathan, Niro

2013-10-01

Perspective taking is often the glue that binds people together. However, we propose that in competitive contexts, perspective taking is akin to adding gasoline to a fire: It inflames already-aroused competitive impulses and leads people to protect themselves from the potentially insidious actions of their competitors. Overall, we suggest that perspective taking functions as a relational amplifier. In cooperative contexts, it creates the foundation for prosocial impulses, but in competitive contexts, it triggers hypercompetition, leading people to prophylactically engage in unethical behavior to prevent themselves from being exploited. The experiments reported here establish that perspective taking interacts with the relational context--cooperative or competitive--to predict unethical behavior, from using insidious negotiation tactics to materially deceiving one's partner to cheating on an anagram task. In the context of competition, perspective taking can pervert the age-old axiom "do unto others as you would have them do unto you" into "do unto others as you think they will try to do unto you."

Learning Physics-based Models in Hydrology under the Framework of Generative Adversarial Networks

Science.gov (United States)

Karpatne, A.; Kumar, V.

2017-12-01

Generative adversarial networks (GANs), that have been highly successful in a number of applications involving large volumes of labeled and unlabeled data such as computer vision, offer huge potential for modeling the dynamics of physical processes that have been traditionally studied using simulations of physics-based models. While conventional physics-based models use labeled samples of input/output variables for model calibration (estimating the right parametric forms of relationships between variables) or data assimilation (identifying the most likely sequence of system states in dynamical systems), there is a greater opportunity to explore the full power of machine learning (ML) methods (e.g, GANs) for studying physical processes currently suffering from large knowledge gaps, e.g. ground-water flow. However, success in this endeavor requires a principled way of combining the strengths of ML methods with physics-based numerical models that are founded on a wealth of scientific knowledge. This is especially important in scientific domains like hydrology where the number of data samples is small (relative to Internet-scale applications such as image recognition where machine learning methods has found great success), and the physical relationships are complex (high-dimensional) and non-stationary. We will present a series of methods for guiding the learning of GANs using physics-based models, e.g., by using the outputs of physics-based models as input data to the generator-learner framework, and by using physics-based models as generators trained using validation data in the adversarial learning framework. These methods are being developed under the broad paradigm of theory-guided data science that we are developing to integrate scientific knowledge with data science methods for accelerating scientific discovery.

PHP frameworks

OpenAIRE

Srša, Aljaž

2016-01-01

The thesis presents one of the four most popular PHP web frameworks: Laravel, Symfony, CodeIgniter and CakePHP. These frameworks are compared with each other according to the four criteria, which can help with the selection of a framework. These criteria are size of the community, quality of official support, comprehensibility of framework’s documentation and implementation of functionalities in individual frameworks, which are automatic code generation, routing, object-relational mapping and...

Using the living laboratory framework as a basis for understanding next-generation analyst work

Science.gov (United States)

McNeese, Michael D.; Mancuso, Vincent; McNeese, Nathan; Endsley, Tristan; Forster, Pete

2013-05-01

The preparation of next generation analyst work requires alternative levels of understanding and new methodological departures from the way current work transpires. Current work practices typically do not provide a comprehensive approach that emphasizes the role of and interplay between (a) cognition, (b) emergent activities in a shared situated context, and (c) collaborative teamwork. In turn, effective and efficient problem solving fails to take place, and practice is often composed of piecemeal, techno-centric tools that isolate analysts by providing rigid, limited levels of understanding of situation awareness. This coupled with the fact that many analyst activities are classified produces a challenging situation for researching such phenomena and designing and evaluating systems to support analyst cognition and teamwork. Through our work with cyber, image, and intelligence analysts we have realized that there is more required of researchers to study human-centered designs to provide for analyst's needs in a timely fashion. This paper identifies and describes how The Living Laboratory Framework can be utilized as a means to develop a comprehensive, human-centric, and problem-focused approach to next generation analyst work, design, and training. We explain how the framework is utilized for specific cases in various applied settings (e.g., crisis management analysis, image analysis, and cyber analysis) to demonstrate its value and power in addressing an area of utmost importance to our national security. Attributes of analyst work settings are delineated to suggest potential design affordances that could help improve cognitive activities and awareness. Finally, the paper puts forth a research agenda for the use of the framework for future work that will move the analyst profession in a viable manner to address the concerns identified.

Self-generated magnetic fields in direct-drive implosion experiments

Energy Technology Data Exchange (ETDEWEB)

Igumenshchev, I. V.; Nilson, P. M.; Goncharov, V. N. [Laboratory for Laser Energetics, University of Rochester, 250 East River Road, Rochester, New York 14623 (United States); Zylstra, A. B.; Li, C. K.; Petrasso, R. D. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

2014-06-15

Electric and self-generated magnetic fields in direct-drive implosion experiments on the OMEGA Laser Facility were investigated employing radiography with ∼10- to 60-MeV protons. The experiment used plastic-shell targets with imposed surface defects (glue spots, wires, and mount stalks), which enhance self-generated fields. The fields were measured during the 1-ns laser drive with an on-target intensity ∼10{sup 15} W/cm{sup 2}. Proton radiographs show multiple ring-like structures produced by electric fields ∼10{sup 7} V/cm and fine structures from surface defects, indicating self-generated fields up to ∼3 MG. These electric and magnetic fields show good agreement with two-dimensional magnetohydrodynamic simulations when the latter include the ∇T{sub e} × ∇n{sub e} source, Nernst convection, and anisotropic resistivity. The simulations predict that self-generated fields affect heat fluxes in the conduction zone and, through this, affect the growth of local perturbations.

Synthetic spider silk fibers spun from Pyriform Spidroin 2, a glue silk protein discovered in orb-weaving spider attachment discs.

Science.gov (United States)

Geurts, Paul; Zhao, Liang; Hsia, Yang; Gnesa, Eric; Tang, Simon; Jeffery, Felicia; La Mattina, Coby; Franz, Andreas; Larkin, Leah; Vierra, Craig

2010-12-13

Spider attachment disc silk fibers are spun into a viscous liquid that rapidly solidifies, gluing dragline silk fibers to substrates for locomotion or web construction. Here we report the identification and artificial spinning of a novel attachment disc glue silk fibroin, Pyriform Spidroin 2 (PySp2), from the golden orb weaver Nephila clavipes . MS studies support PySp2 is a constituent of the pyriform gland that is spun into attachment discs. Analysis of the PySp2 protein architecture reveals sequence divergence relative to the other silk family members, including the cob weaver glue silk fibroin PySp1. PySp2 contains internal block repeats that consist of two subrepeat units: one dominated by Ser, Gln, and Ala and the other Pro-rich. Artificial spinning of recombinant PySp2 truncations shows that the Ser-Gln-Ala-rich subrepeat is sufficient for the assembly of polymeric subunits and subsequent fiber formation. These studies support that both orb- and cob-weaving spiders have evolved highly polar block-repeat sequences with the ability to self-assemble into fibers, suggesting a strategy to allow fiber fabrication in the liquid environment of the attachment discs.

Endovascular Treatment of Pseudoaneurysm of the Common Hepatic Artery with Intra-aneurysmal Glue (N-Butyl 2-Cyanoacrylate) Embolization

International Nuclear Information System (INIS)

Garg, Ashwin; Banait, Swati; Babhad, Sudeep; Kanchankar, Niraj; Nimade, Pradeep; Panchal, Chintan

2007-01-01

A 40-year-old man, a chronic alcoholic, presented with acute epigastric pain. Selective celiac arteriography showed a pseudoaneurysm arising from the common hepatic artery. We hereby describe a technical innovation where complete pseudoaneurysm exclusion was seen after intra-aneurysmal N-butyl 2-cyanoacrylate (glue) injection with preservation of antegrade hepatic arterial flow and conclude that intra-aneurysmal liquid injection may have potential as a therapeutic option to reconstruct a defective vessel wall and thereby maintain the antegrade flow

Analysis of the η(548) ->π+π-π0 and η'(958) ->π+π- η channels using a 8-9 GeV tagged photon beam for the GlueX Experiment

Science.gov (United States)

Beattie, Tegan; Papandreou, Zisis; Stevens, Justin; GlueX Collaboration

2016-09-01

The primary goal of the GlueX experiment is to conduct a definitive mapping of states in the light meson sector with an emphasis on searching for exotic hybrid mesons as evidence of gluonic excitations. The experiment, housed in the Hall-D facility at Jefferson Lab following its accelerator upgrade to 12 GeV, is now entering the physics data taking phase. The η(548) and η'(958) mesons are two of the richest unflavoured light mesons readily available at GlueX energies for studying resonances. Many other light mesons have decay channels involving the η mesons with significant branching ratios, and πη / πη' resonances are among the top contenders for possibly-accessible exotic and hybrid resonances which GlueX aims to study. As such, the ability to reconstruct pure η/η' samples and analyze their decays is of utmost importance for understanding future work on more complicated analyses. Preliminary analysis results from commissioning data will be presented. This work was supported by NSERC Grant SAPJ-326516 and Jefferson Science Associates, LLC, who operates Jefferson Lab under U.S. DOE Contract No. DE-AC05-06OR23177.

Persona Rights for User-Generated Content: A Normative Framework for Privacy and Intellectual Property Regulation

Directory of Open Access Journals (Sweden)

Tamara Shepherd

2012-02-01

Full Text Available This article introduces the term “persona rights” as a normative conceptual framework for analyzing the language of regulatory debates around privacy and intellectual property online, mainly from a Canadian perspective. In using the concept of persona rights to interrogate and critique the current limitations of regulatory discourses in protecting user rights online, the legal implications of persona rights law are translated into more conceptual terms. As a normative framework, persona rights is shown to be useful in addressing the gaps in regulatory understandings of privacy and intellectual property – particularly in spaces for user-generated content (UGC – and in suggesting how policy might be written to account for user rights to the integrity of identity in commercial UGC platforms.

Environmental implications of electricity generation in an integrated long-term planning framework

International Nuclear Information System (INIS)

Turner, Graham M.; West, James

2012-01-01

Long-term, integrated modelling of electricity generation capacity and its operational requirements is important for coherent energy policy because of the multi-decadal lifespan of such plant, and because related fuel requirements, water consumption, and greenhouse gas emissions impact other sectors. This paper describes a physical model of electricity generation designed for long-term simulations, including the reproduction of decades of historical data, and its application to key policy questions. The simulation uses a dynamic, physical input–output model for the basic material and energy industries, embedded in an economy-wide stocks and flows framework (SFF). The historical reproduction, illustrated for the state of Victoria, is based on integrating bottom-up technical data on physical processes as inputs, and validating output against top-down aggregate data. We show that while greenhouse gas emissions would decrease significantly with the aggressive introduction of cleaner generation technology, long-term reductions are difficult to maintain against ongoing growth in consumption. Additionally, our sensitivity analysis identifies the importance of rapid action due to the age structure of operating power stations. We also identify significant imposts of alternative power generation on land and water resources, though a business-as-usual scenario would impose greater losses of water resources. - Highlights: ► System-wide dynamic analysis is needed to avoid unintended adverse environmental outcomes. ► Dynamics of long-lived plant is important in transitions for reducing greenhouse gas emissions. ► Large gains in GHG emissions efficiency of generation portfolios fail to maintain low emissions.

nQuire: a statistical framework for ploidy estimation using next generation sequencing.

Science.gov (United States)

Weiß, Clemens L; Pais, Marina; Cano, Liliana M; Kamoun, Sophien; Burbano, Hernán A

2018-04-04

Intraspecific variation in ploidy occurs in a wide range of species including pathogenic and nonpathogenic eukaryotes such as yeasts and oomycetes. Ploidy can be inferred indirectly - without measuring DNA content - from experiments using next-generation sequencing (NGS). We present nQuire, a statistical framework that distinguishes between diploids, triploids and tetraploids using NGS. The command-line tool models the distribution of base frequencies at variable sites using a Gaussian Mixture Model, and uses maximum likelihood to select the most plausible ploidy model. nQuire handles large genomes at high coverage efficiently and uses standard input file formats. We demonstrate the utility of nQuire analyzing individual samples of the pathogenic oomycete Phytophthora infestans and the Baker's yeast Saccharomyces cerevisiae. Using these organisms we show the dependence between reliability of the ploidy assignment and sequencing depth. Additionally, we employ normalized maximized log- likelihoods generated by nQuire to ascertain ploidy level in a population of samples with ploidy heterogeneity. Using these normalized values we cluster samples in three dimensions using multivariate Gaussian mixtures. The cluster assignments retrieved from a S. cerevisiae population recovered the true ploidy level in over 96% of samples. Finally, we show that nQuire can be used regionally to identify chromosomal aneuploidies. nQuire provides a statistical framework to study organisms with intraspecific variation in ploidy. nQuire is likely to be useful in epidemiological studies of pathogens, artificial selection experiments, and for historical or ancient samples where intact nuclei are not preserved. It is implemented as a stand-alone Linux command line tool in the C programming language and is available at https://github.com/clwgg/nQuire under the MIT license.

Effects of diode laser welding with dye-enhanced glue on tensile strength of sutures commonly used in urology.

Science.gov (United States)

Kirsch, A J; Chang, D T; Kayton, M L; Libutti, S K; Connor, J P; Hensle, T W

1996-01-01

Tissue welding using laser-activated protein solders may soon become an alternative to sutured tissue approximation. In most cases, approximating sutures are used both to align tissue edges and provide added tensile strength. Collateral thermal injury, however, may cause disruption of tissue alignment and weaken the tensile strength of sutures. The objective of this study was to evaluate the effect of laser welding on the tensile strength of suture materials used in urologic surgery. Eleven types of sutures were exposed to diode laser energy (power density = 15.9 W/cm2) for 10, 30, and 60 seconds. Each suture was compared with and without the addition of dye-enhanced albumin-based solder. After exposure, each suture material was strained (2"/min) until ultimate breakage on a tensometer and compared to untreated sutures using ANOVA. The strength of undyed sutures were not significantly affected; however, violet and green-dyed sutures were in general weakened by laser exposure in the presence of dye-enhanced glue. Laser activation of the smallest caliber, dyed sutures (7-0) in the presence of glue caused the most significant loss of tensile strength of all sutures tested. These results indicate that the thermal effects of laser welding using our technique decrease the tensile strength of dyed sutures. A thermally resistant suture material (undyed or clear) may prevent disruption of wounds closed by laser welding techniques.

Boll weevil within season and off-season activity monitored using a pheromone-and-glue reusable tube trap

Directory of Open Access Journals (Sweden)

Robério Carlos dos Santos Neves

Full Text Available ABSTRACT: The boll weevil colonizes cotton fields as early as cotton squaring, causing significant losses due to feeding and protected development inside fruiting structures throughout crop phenology. Successful control depends on control of adults and their accurate detection when they colonize the crops. The commercial trap and boll weevil attract-and-control tubes (BWACT are the only available tools to monitor and attract-and-kill boll weevil, despite limitation in efficacy, and insecticide in BWACT is not allowed in organic production. A grandlure-and-glue reusable and insecticide-free tube (GGT made with polyvinyl chloride tube, smeared with entomological glue, and lured with pheromone was tested to detect boll weevil activity across various seasons. Boll weevil showed activity during growing season and off-season from 2009 to 2012 in the Semiarid and with higher numbers captured in GGT in comparisons to commercial traps. GGT was able to detect early weevils in the field right after planting. Further, the overall averages resulted in 34-, 16.8-, and 7.5-times more weevils captured in GGTs compared to the traps during stalk destruction in the Semiarid 2011 and Cerrado season 2012/13 and during the harvesting period in the Cerrado season 2011/12, respectively. Therefore, boll weevils were captured actively during season and off-season and early captures obtained in GGT compared to traps showed a better correlation between captures and square damage.

MitoGen: A Framework for Generating 3D Synthetic Time-Lapse Sequences of Cell Populations in Fluorescence Microscopy.

Science.gov (United States)

Svoboda, David; Ulman, Vladimir

2017-01-01

The proper analysis of biological microscopy images is an important and complex task. Therefore, it requires verification of all steps involved in the process, including image segmentation and tracking algorithms. It is generally better to verify algorithms with computer-generated ground truth datasets, which, compared to manually annotated data, nowadays have reached high quality and can be produced in large quantities even for 3D time-lapse image sequences. Here, we propose a novel framework, called MitoGen, which is capable of generating ground truth datasets with fully 3D time-lapse sequences of synthetic fluorescence-stained cell populations. MitoGen shows biologically justified cell motility, shape and texture changes as well as cell divisions. Standard fluorescence microscopy phenomena such as photobleaching, blur with real point spread function (PSF), and several types of noise, are simulated to obtain realistic images. The MitoGen framework is scalable in both space and time. MitoGen generates visually plausible data that shows good agreement with real data in terms of image descriptors and mean square displacement (MSD) trajectory analysis. Additionally, it is also shown in this paper that four publicly available segmentation and tracking algorithms exhibit similar performance on both real and MitoGen-generated data. The implementation of MitoGen is freely available.

Comparative Study of Neural Network Frameworks for the Next Generation of Adaptive Optics Systems.

Science.gov (United States)

González-Gutiérrez, Carlos; Santos, Jesús Daniel; Martínez-Zarzuela, Mario; Basden, Alistair G; Osborn, James; Díaz-Pernas, Francisco Javier; De Cos Juez, Francisco Javier

2017-06-02

Many of the next generation of adaptive optics systems on large and extremely large telescopes require tomographic techniques in order to correct for atmospheric turbulence over a large field of view. Multi-object adaptive optics is one such technique. In this paper, different implementations of a tomographic reconstructor based on a machine learning architecture named "CARMEN" are presented. Basic concepts of adaptive optics are introduced first, with a short explanation of three different control systems used on real telescopes and the sensors utilised. The operation of the reconstructor, along with the three neural network frameworks used, and the developed CUDA code are detailed. Changes to the size of the reconstructor influence the training and execution time of the neural network. The native CUDA code turns out to be the best choice for all the systems, although some of the other frameworks offer good performance under certain circumstances.

Evaluation of a feature extraction framework for FPGA firmware generation during a beam-test at CERN-SPS for the CBM-TRD experiment

Energy Technology Data Exchange (ETDEWEB)

Garcia Chavez, Cruz de Jesus; Munoz Castillo, Carlos Enrique; Kebschull, Udo [Infrastructure and Computer Systems in Data Processing (IRI), Goethe University, Frankfurt am Main (Germany); Collaboration: CBM-Collaboration

2016-07-01

A feature extraction framework has been developed to allow easy FPGA firmware generation for specific feature extraction algorithms in order to find and extract regions of interest within time-based signals. This framework allows the instantiation of multiple well-known feature extraction algorithms such as center of gravity, time over threshold and cluster finder, just to mention a few of them. A graphical user interface has also been built on top of the framework to provide a user-friendly way to visualize the data-flow architecture across processing stages. The FPGA platform constraints are automatically set up by the framework itself. This feature reduces the need of low-level hardware configuration knowledge that would normally be provided by the user, centering the attention in setting up the processing algorithms for the given task more than in writing hardware description code. During November 2015, a beam-test was performed at the CERN-SPS hall. The presented framework was used to generate a firmware for the SysCore3 FPGA development board used to readout two TRD detectors by means of the SPADIC 1.0 front-end chip. The framework architecture, design methodology, as well as the achieved results during the mentioned beam-test are presented.

Zwitterionic Nanofibers of Super-Glue for Transparent and Biocompatible Multi-Purpose Coatings

Science.gov (United States)

Mele, Elisa; Heredia-Guerrero, José A.; Bayer, Ilker S.; Ciofani, Gianni; Genchi, Giada G.; Ceseracciu, Luca; Davis, Alexander; Papadopoulou, Evie L.; Barthel, Markus J.; Marini, Lara; Ruffilli, Roberta; Athanassiou, Athanassia

2015-09-01

Here we show that macrozwitterions of poly(ethyl 2-cyanoacrylate), commonly called Super Glue, can easily assemble into long and well defined fibers by electrospinning. The resulting fibrous networks are thermally treated on glass in order to create transparent coatings whose superficial morphology recalls the organization of the initial electrospun mats. These textured coatings are characterized by low liquid adhesion and anti-staining performance. Furthermore, the low friction coefficient and excellent scratch resistance make them attractive as solid lubricants. The inherent texture of the coatings positively affects their biocompatibility. In fact, they are able to promote the proliferation and differentiation of myoblast stem cells. Optically-transparent and biocompatible coatings that simultaneously possess characteristics of low water contact angle hysteresis, low friction and mechanical robustness can find application in a wide range of technological sectors, from the construction and automotive industries to electronic and biomedical devices.

Tolerance of glue embolization under local anesthesia in varicoceles: A comparative study of two different cyanoacrylates

Energy Technology Data Exchange (ETDEWEB)

Vanlangenhove, Peter, E-mail: peter.vanlangenhove@uzgent.be [Department of Vascular and Interventional Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium); Everaert, Karel [Department of Urology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium); Van Maele, Georges [Department of Statistics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium); Defreyne, Luc [Department of Vascular and Interventional Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium)

2014-03-15

Purpose: To find out whether in varicocele embolization the copolymer cyanoacrylate glue (NBCA-MS) has a better patient tolerance compared to the monomer n-butyl-2-cyanoacrylate (NBCA). Materials and methods: N = 112 insufficient spermatic veins (left sided N = 84, right sided N = 28) diagnosed in N = 83 adult males were prospectively randomized for blinded embolization with either NBCA N = 54 (Histoacryl) or with NBCA-MS N = 58 (Glubran2). Before, during and up to one week after embolization, patient discomfort was assessed by a standardized pain scale. Type, location and side of discomfort were noted. Statistical analysis was performed with the Mann–Whitney U-test, the McNemar test and the Fisher's exact test. Results: Embolization caused discomfort in N = 48/112 (43%) spermatic veins, comprising N = 26/54 (48%) in the NBCA group and N = 22/58 (38%) in the NBCA-MS group. During the week after embolization, the overall number of discomfort reports rose to N = 62/106 (59%), with an increase to N = 30/53 (57%) in the NBCA group and to N = 32/53 (60%) in the NBCA-MS group. The number of immediate grade 2 to 4 pain reactions was N = 22/112 (20%), and rose to N = 37/106 (35%) after one week. No difference in discomfort during embolization and at 1 week after treatment was noted. Characteristics, severity grading, and location of discomfort were similar in both NBCA groups, regardless the time point of observation. Conclusion: Discomfort after glue embolization of varicocele is a common side effect, which might evolve to pain. The assumed lower inflammatory reaction on NBCA-MS was not translated in an improved tolerance.

Requirements for a Next Generation Framework: ATLAS Experience

CERN Document Server

Kama, Sami; The ATLAS collaboration

2015-01-01

The challenge faced by HEP experiments from the current and expected architectural evolution of CPUs and co-processors is how to successfully exploit concurrency and keep memory consumption within reasonable limits. This is a major change from frameworks which were designed for serial event processing on single core processors in the 2000s. ATLAS has recently considered this problem in some detail through its Future Frameworks Requirements group. Here we report on the major considerations of the group, which was charged with considering the best strategies to exploit current and anticipated CPU technologies. The group has re-examined the basic architecture of event processing and considered how the building blocks of a framework (algorithms, services, tools and incidents) should evolve. The group has also had to take special care to ensure that the use cases of the ATLAS high level trigger are encompassed, which differ in important ways from offline event processing (for example, 99% of events are rejected, w...

GlueX: The Search for Gluonic Excitations at Jefferson Laboratory

Energy Technology Data Exchange (ETDEWEB)

D.S. Carman

2005-08-21

One of the unanswered and most fundamental questions in physics regards the nature of the confinement mechanism of quarks and gluons in quantum chromodynamics (QCD). Exotic hybrid mesons manifest gluonic degrees of freedom and their detailed spectroscopy will provide the precision data necessary to test assumptions in lattice QCD and the specific phenomenology leading to confinement. Photoproduction is expected to be a particularly effective manner to produce exotic hybrids, however, existing data using photon beams are sparse. At Jefferson Laboratory, plans are underway by the GlueX Collaboration to use the coherent bremsstrahlung technique to produce a linearly polarized photon beam. A solenoid-based hermetic detector will be used to collect data on meson production and decays with statistics that will exceed existing photoproduction data by several orders of magnitude after the first year of running. In order to reach the ideal photon energy of 9 GeV required for these studies, the energy of the Jefferson Laboratory electron accelerator, CEBAF, will be doubled from its current maximum energy of 6 GeV to 12 GeV. The physics motivating the search and the status of the project are reviewed.

Gas chromatography-mass spectrometry characterization of the varnish and glue of an ancient 18th century double bass.

Science.gov (United States)

Caruso, Francesco; Orecchio, Santino; Cicero, Maria Grazia; Di Stefano, Cosimo

2007-04-20

A GC-MS investigation is conducted on the double bass "Panormus", property of Conservatorio di Musica "Vincenzo Bellini" in Palermo. The most important components of the varnish (fatty acids) and of the glue (proteinaceous amino acids), with which the musical instrument was treated in the past, are determined. The analyses are carried out by prior derivatization of fatty acids by acidic methanol and of amino acids by acidic methanol and trifluoroacetic anhydride (TFAA). Analytes identification is achieved by direct comparison with several reference materials and the use of a digitized library.

Developing a framework to generate evidence of health outcomes from social media use in chronic disease management.

Science.gov (United States)

Merolli, Mark; Gray, Kathleen; Martin-Sanchez, Fernando

2013-01-01

While there is an abundance of evidence-based practice (EBP) recommendations guiding management of various chronic diseases, evidence suggesting best practice for using social media to improve health outcomes is inadequate. The variety of social media platforms, multiple potential uses, inconsistent definitions, and paucity of rigorous studies, make it difficult to measure health outcomes reliably in chronic disease management. Most published investigations report on an earlier generation of online tools, which are not as user-centered, participatory, engaging, or collaborative, and thus may work differently for health self-management. The challenge to establish a sound evidence base for social media use in chronic disease starts with the need to define criteria and methods to generate and evaluate evidence. The authors' key objective is to develop a framework for research and practice that addresses this challenge. This paper forms part of a larger research project that presents a conceptual framework of how evidence of health outcomes can be generated from social media use, allowing social media to be utilized in chronic disease management more effectively. Using mixed methods incorporating a qualitative literature review, a survey and a pilot intervention, the research closely examines the therapeutic affordances of social media, people with chronic pain (PWCP) as a subset of chronic disease management, valid outcome measurement of patient-reported (health) outcomes (PRO), the individual needs of people living with chronic disease, and finally translation of the combined results to improve evidence-based decision making about social media use in this context. Extensive review highlights various affordances of social media that may prove valuable to understanding social media's effect on individual health outcomes. However, without standardized PRO instruments, we are unable to definitively investigate these effects. The proposed framework that we offer outlines

Staple Line Reinforcement During Laparoscopic Sleeve Gastrectomy: Absorbable Monofilament, Barbed Suture, Fibrin Glue, or Nothing? Results of a Prospective Randomized Study.

Science.gov (United States)

Carandina, S; Tabbara, M; Bossi, M; Valenti, A; Polliand, C; Genser, L; Barrat, Christophe

2016-02-01

Laparoscopic sleeve gastrectomy (LSG) is associated with serious complications, such as staple line (SL) leaks and bleeding. In order to prevent the occurrence of these complications, surgeons have advocated the need to strengthen the staple line. The aim of this randomized controlled study was to compare the efficacy of three different ways of strengthening of the SL in LSG in preventing surgical post-operative complications. Between April 2012 and December 2014, 600 patients (pts) scheduled for LSG were prospectively randomized into groups without SL reinforcement (group A) or with SL reinforcement including fibrin glue coverage (group B), or oversewn SL with imbricating absorbable (Monocryl™; group C) or barbed (V lock®) running suture (group D). Primary endpoints were post-operative leaks, bleeding, and stenosis, while secondary outcomes consisted of the time to perform the staple line reinforcement (SLR) and total operative time. Mean SLR operative time was lower for group B (3.4 ± 1.3 min) compared with that for groups C (26.8 ± 8.5 min) and D (21.1 ± 8.4 min) (p running suture or with fibrin glue, is an unrewarding surgical act with the sole effect of prolonging the operative time.

Optimal Management of DoD Lands for Military Training, Ecosystem Services, and Renewable Energy Generation: Framework and Data Requirements

Science.gov (United States)

2013-01-01

published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/ client /default. Base Facilities Environmental Quality ERDC/CERL TR...generation—on the primary land-management driver, the military training. 1.3 Approach The modeling framework was developed to generate a Pareto

A system-of-systems framework for the reliability analysis of distributed generation systems accounting for the impact of degraded communication networks

International Nuclear Information System (INIS)

Mo, Hua-Dong; Li, Yan-Fu; Zio, Enrico

2016-01-01

Highlights: • A system-of-systems framework is proposed for reliability analysis of DG system. • The impact of degraded communication networks is included and quantified. • Various uncertainties and contingencies in the DG system are considered. • A Monte Carlo simulation-optimal power flow computational framework is developed. • The results of the application study show the power of the proposed framework. - Abstract: Distributed generation (DG) systems install communication networks for managing real-time energy imbalance. Different from previous research, which typically assumes perfect communication networks, this work aims to quantitatively account for the impact of degraded communication networks on DG systems performance. The degraded behavior of communication networks is modeled by stochastic continuous time transmission delays and packet dropouts. On the DG systems side, we consider the inherent uncertainties of renewable energy sources, loads and energy prices. We develop a Monte Carlo simulation-optimal power flow (MCS-OPF) computational framework that is capable of generating consecutive time-dependent operating scenarios of the integrated system. Quantitative analysis is carried out to measure the impact of communication networks degradation onto the DG systems. For illustration, the framework is applied to a modified IEEE 13 nodes test feeder. The results demonstrate that the degraded communication networks can significantly deteriorate the performance of the integrated system. A grey differential model-based prediction method for reconstructing missing data is effective in mitigating the influence of the degraded communication networks.

Second generation CO2 FEP analysis: Cassifcarbon sequestration scenario identification framework

NARCIS (Netherlands)

Yavuz, F.T.; Tilburg, T. van; Pagnier, H.

2008-01-01

A novel scenario analysis framework has been created, called Carbon Sequestration Scenario Identification Framework (CASSIF). This framework addresses containment performance defined by the three major categories: well, fault and seal integrity. The relevant factors that influence the integrity are

Treatment for intractable anemia with the traditional Chinese medicines Hominis Placenta and Cervi Cornus Colla (deer antler glue

Directory of Open Access Journals (Sweden)

Yasuyo Hijikata

2009-05-01

Full Text Available Yasuyo Hijikata1, Takashi Kano2, Lu Xi31Toyodo Hijikata Clinic, Osaka, Japan; 2Kano Clinic, Osaka city, Osaka, Japan; 3Traditional Chinese Medicine Institute, Si-chuan Province, ChinaObjective: Intractable anemia, such as aplastic anemia or that presumably associated with chronic herpes virus infections, sometimes require bone marrow transplant. We investigated the use of traditional Chinese medicine (TCM for the treatment of intractable anemia. Method: Placenta Hominis (PH, steam boiled and roasted, and Cervi Cornus Colla (deer antler glue has been used in China for hundreds of years to treat anemia. After consent was obtained, we prescribed these two materials for a 74-year-old female with aplastic anemia and a 26-year-old male with presumably a virus-induced anemia. Concomitant conventional therapy was continued in both patients as prescribed by their respective attending physicians. Conclusion: Conventional therapy with steroid hormones, immunosuppressive drugs, platelet and erythrocyte transfusions were not effective in these patients. In addition, both patients suffered from serious side effects. In two patients, ingestion of Placenta Hominis and Cervi Cornus Colla with TCM prescriptions increased the platelet and enhanced the hemoglobin concentration in several months of therapy accompanied by a dramatic improvement in quality of life. The addition to conventional therapy of PH and Cervi Cornus Colla, the latter of which is very easy to obtain, may be one of the potentially advantageous choices in case of otherwise intractable anemia.Keywords: placenta, antler glue, Cervi Cornus Colla, anemia, aplastic anemia

A framework for generating and analyzing movement paths on ecological landscapes.

Science.gov (United States)

Getz, Wayne M; Saltz, David

2008-12-09

The movement paths of individuals over landscapes are basically represented by sequences of points (x(i), y(i)) occurring at times t(i). Theoretically, these points can be viewed as being generated by stochastic processes that in the simplest cases are Gaussian random walks on featureless landscapes. Generalizations have been made of walks that (i) take place on landscapes with features, (ii) have correlated distributions of velocity and direction of movement in each time interval, (iii) are Lévy processes in which distance or waiting-time (time-between steps) distributions have infinite moments, or (iv) have paths bounded in space and time. We begin by demonstrating that rather mild truncations of fat-tailed step-size distributions have a dramatic effect on dispersion of organisms, where such truncations naturally arise in real walks of organisms bounded by space and, more generally, influenced by the interactions of physiological, behavioral, and ecological factors with landscape features. These generalizations permit not only increased realism and hence greater accuracy in constructing movement pathways, but also provide a biogeographically detailed epistemological framework for interpreting movement patterns in all organisms, whether tossed in the wind or willfully driven. We illustrate the utility of our framework by demonstrating how fission-fusion herding behavior arises among individuals endeavoring to satisfy both nutritional and safety demands in heterogeneous environments. We conclude with a brief discussion of potential methods that can be used to solve the inverse problem of identifying putative causal factors driving movement behavior on known landscapes, leaving details to references in the literature.

In situ generation of Ni nanoparticles from metal-organic framework precursors and their use for biomass hydrodeoxygenation.

Science.gov (United States)

Čelič, Tadeja Birsa; Grilc, Miha; Likozar, Blaž; Tušar, Nataša Novak

2015-05-22

So far, in situ-generated Ni nanoparticles have been reported to be efficient catalysts for tar cracking during wood liquefaction by pyrolysis. Herein, their performance in further bio-oil conversion steps is evaluated. Nanoparticles were generated for the first time from a Ni-containing metal-organic framework, MIL-77, during the hydrotreatment of glycerol-solvolyzed lignocellulosic (LC) biomass. Reactions were conducted at 300 °C and the H2 pressure was 8 MPa in a slurry reactor. The catalytic activity and selectivity of the deoxygenation and hydrocracking reactions for real biomass-derived feedstock using in situ-generated nanoparticles was compared with Ni nanoparticles dispersed on a silica-alumina support (commercial Ni/SiO2 -Al2 O3 catalyst). The mass activity of the in situ-generated nanoparticles for hydrogenolysis was more than ten times higher in comparison to their commercial analogues, and their potential for the use in LC biorefinery is discussed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Glue Ear, Hearing Loss and IQ: An Association Moderated by the Child’s Home Environment

Science.gov (United States)

Hall, Amanda J.; Maw, Richard; Midgley, Elizabeth; Golding, Jean; Steer, Colin

2014-01-01

Background Glue ear or otitis media with effusion (OME) is common in children and may be associated with hearing loss (HL). For most children it has no long lasting effects on cognitive development but it is unclear whether there are subgroups at higher risk of sequelae. Objectives To examine the association between a score comprising the number of times a child had OME and HL (OME/HL score) in the first four/five years of life and IQ at age 4 and 8. To examine whether any association between OME/HL and IQ is moderated by socioeconomic, child or family factors. Methods Prospective, longitudinal cohort study: the Avon Longitudinal Study of Parents and Children (ALSPAC). 1155 children tested using tympanometry on up to nine occasions and hearing for speech (word recognition) on up to three occasions between age 8 months and 5 years. An OME/HL score was created and associations with IQ at ages 4 and 8 were examined. Potential moderators included a measure of the child’s cognitive stimulation at home (HOME score). Results For the whole sample at age 4 the group with the highest 10% OME/HL scores had performance IQ 5 points lower [95% CI −9, −1] and verbal IQ 6 points lower [95% CI −10, −3] than the unaffected group. By age 8 the evidence for group differences was weak. There were significant interactions between OME/HL and the HOME score: those with high OME/HL scores and low 18 month HOME scores had lower IQ at age 4 and 8 than those with high OME/HL scores and high HOME scores. Adjusted mean differences ranged from 5 to 8 IQ points at age 4 and 8. Conclusions The cognitive development of children from homes with lower levels of cognitive stimulation is susceptible to the effects of glue ear and hearing loss. PMID:24498289

Generation of multipartite entangled states for chains of atoms in the framework of cavity-QED

Energy Technology Data Exchange (ETDEWEB)

Gonta, Denis

2010-07-07

Cavity quantum electrodynamics is a research field that studies electromagnetic fields in confined spaces and the radiative properties of atoms in such fields. Experimentally, the simplest example of such system is a single atom interacting with modes of a high-finesse resonator. Theoretically, such system bears an excellent framework for quantum information processing in which atoms and light are interpreted as bits of quantum information and their mutual interaction provides a controllable entanglement mechanism. In this thesis, we present several practical schemes for generation of multipartite entangled states for chains of atoms which pass through one or more high-finesse resonators. In the first step, we propose two schemes for generation of one- and two-dimensional cluster states of arbitrary size. These schemes are based on the resonant interaction of a chain of Rydberg atoms with one or more microwave cavities. In the second step, we propose a scheme for generation of multipartite W states. This scheme is based on the off-resonant interaction of a chain of three-level atoms with an optical cavity and a laser beam. We describe in details all the individual steps which are required to realize the proposed schemes and, moreover, we discuss several techniques to reveal the non-classical correlations associated with generated small-sized entangled states. (orig.)

Generation of multipartite entangled states for chains of atoms in the framework of cavity-QED

International Nuclear Information System (INIS)

Gonta, Denis

2010-01-01

Cavity quantum electrodynamics is a research field that studies electromagnetic fields in confined spaces and the radiative properties of atoms in such fields. Experimentally, the simplest example of such system is a single atom interacting with modes of a high-finesse resonator. Theoretically, such system bears an excellent framework for quantum information processing in which atoms and light are interpreted as bits of quantum information and their mutual interaction provides a controllable entanglement mechanism. In this thesis, we present several practical schemes for generation of multipartite entangled states for chains of atoms which pass through one or more high-finesse resonators. In the first step, we propose two schemes for generation of one- and two-dimensional cluster states of arbitrary size. These schemes are based on the resonant interaction of a chain of Rydberg atoms with one or more microwave cavities. In the second step, we propose a scheme for generation of multipartite W states. This scheme is based on the off-resonant interaction of a chain of three-level atoms with an optical cavity and a laser beam. We describe in details all the individual steps which are required to realize the proposed schemes and, moreover, we discuss several techniques to reveal the non-classical correlations associated with generated small-sized entangled states. (orig.)

Development of a framework for the neutronics analysis system for next generation (3)

International Nuclear Information System (INIS)

Yokoyama, Kenji; Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro

2010-02-01

Development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems is in progress. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of commercial reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation analysis system provides solutions to the following requirements: (1) flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative proof of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality management and development efficiency. The next-generation analysis system supports many fields, such as thermal-hydraulic analysis, structure analysis, reactor physics etc., and now we are studying reactor physics analysis system for fast reactor in advance. As for reactor physics analysis methods for fast reactor, we have established the JUPITER standard analysis methods based on the past study. But, there has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. That is why, we have developed the next-generation analysis system for reactor physics which reproduces the JUPITER standard analysis method that has been developed so far and newly realizes burnup and design analysis for fast reactor and functions for cross section adjustment. In the present study, we examined in detail the existing design and implementation of ZPPR critical experiment analysis database followed by unification of models within the framework of the next-generation analysis system by

GeNN: a code generation framework for accelerated brain simulations

Science.gov (United States)

Yavuz, Esin; Turner, James; Nowotny, Thomas

2016-01-01

Large-scale numerical simulations of detailed brain circuit models are important for identifying hypotheses on brain functions and testing their consistency and plausibility. An ongoing challenge for simulating realistic models is, however, computational speed. In this paper, we present the GeNN (GPU-enhanced Neuronal Networks) framework, which aims to facilitate the use of graphics accelerators for computational models of large-scale neuronal networks to address this challenge. GeNN is an open source library that generates code to accelerate the execution of network simulations on NVIDIA GPUs, through a flexible and extensible interface, which does not require in-depth technical knowledge from the users. We present performance benchmarks showing that 200-fold speedup compared to a single core of a CPU can be achieved for a network of one million conductance based Hodgkin-Huxley neurons but that for other models the speedup can differ. GeNN is available for Linux, Mac OS X and Windows platforms. The source code, user manual, tutorials, Wiki, in-depth example projects and all other related information can be found on the project website http://genn-team.github.io/genn/.

A new platelet cryoprecipitate glue promoting bone formation after ectopic mesenchymal stromal cell-loaded biomaterial implantation in nude mice.

Science.gov (United States)

Trouillas, Marina; Prat, Marie; Doucet, Christelle; Ernou, Isabelle; Laplace-Builhé, Corinne; Blancard, Patrick Saint; Holy, Xavier; Lataillade, Jean-Jacques

2013-01-04

This study investigated the promising effect of a new Platelet Glue obtained from Cryoprecipitation of Apheresis Platelet products (PGCAP) used in combination with Mesenchymal Stromal Cells (MSC) loaded on ceramic biomaterials to provide novel strategies enhancing bone repair. PGCAP growth factor content was analyzed by ELISA and compared to other platelet and plasma-derived products. MSC loaded on biomaterials (65% hydroxyapatite/35% beta-TCP or 100% beta-TCP) were embedded in PGCAP and grown in presence or not of osteogenic induction medium for 21 days. Biomaterials were then implanted subcutaneously in immunodeficient mice for 28 days. Effect of PGCAP on MSC was evaluated in vitro by proliferation and osteoblastic gene expression analysis and in vivo by histology and immunohistochemistry. We showed that PGCAP, compared to other platelet-derived products, allowed concentrating large amount of growth factors and cytokines which promoted MSC and osteoprogenitor proliferation. Next, we found that PGCAP improves the proliferation of MSC and osteogenic-induced MSC. Furthermore, we demonstrated that PGCAP up-regulates the mRNA expression of osteogenic markers (Collagen type I, Osteonectin, Osteopontin and Runx2). In vivo, type I collagen expressed in ectopic bone-like tissue was highly enhanced in biomaterials embedded in PGCAP in the absence of osteogenic pre-induction. Better results were obtained with 65% hydroxyapatite/35% beta-TCP biomaterials as compared to 100% beta-TCP. We have demonstrated that PGCAP is able to enhance in vitro MSC proliferation, osteoblastic differentiation and in vivo bone formation in the absence of osteogenic pre-induction. This clinically adaptable platelet glue could be of interest for improving bone repair.

A New Potential Cause in the Development of Toxic Anterior Segment Syndrome: Fibrin Glue

Directory of Open Access Journals (Sweden)

Selçuk Sızmaz

2014-08-01

Full Text Available Objectives: To present a potential cause for toxic anterior segment syndrome (TASS. Materials and Methods: We report 4 cases of TASS that occurred following uneventful phacoemulsification and intraocular lens implantation. Results: The 4 cases were the first consecutive 2 cases of 2 different surgery days, 5 months apart. The most prominent sign of TASS was limbus-to-limbus corneal edema. Pain and/or intraocular pressure rise were also common. All surgical and presurgical procedures were checked after the first outbreak, whereas the second outbreak required further investigation. Fibrin glue remnants from preceding pterygium surgery with conjunctival autografting were found to be the potential cause. Despite intensive corticosteroid therapy, corneal edema did not resolve in 2 patients who underwent keratoplasty. Conclusion: TASS is a sight-threatening condition which requires thorough investigation for prevention of new cases. All steps must be carefully revised. (Turk J Ophthalmol 2014; 44: 280-3

Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues† †Electronic supplementary information (ESI) available: Synthesis of TEG–BA, Gluen–BA, mGluen–BA and Gluen–Ph; 1H NMR, 13C NMR, MALDI-TOF MS, electronic absorption, and CD spectra; zeta potential distributions; SLS plots; DLS histograms; and related experimental procedures. See DOI: 10.1039/c5sc00524h Click here for additional data file.

Science.gov (United States)

Mogaki, Rina

2015-01-01

Water-soluble bioadhesive polymers bearing multiple guanidinium ion (Gu+) pendants at their side-chain termini (Gluen–BA, n = 10 and 29) that were conjugated with benzamidine (BA) as a trypsin inhibitor were developed. The Gluen–BA molecules are supposed to adhere to oxyanionic regions of the trypsin surface, even in buffer, via a multivalent Gu+/oxyanion salt-bridge interaction, such that their BA group properly blocks the substrate-binding site. In fact, Glue10–BA and Glue29–BA exhibited 35- and 200-fold higher affinities for trypsin, respectively, than a BA derivative without the glue moiety (TEG–BA). Most importantly, Glue10–BA inhibited the protease activity of trypsin 13-fold more than TEG–BA. In sharp contrast, mGlue27–BA, which bears 27 Gu+ units along the main chain and has a 5-fold higher affinity than TEG–BA for trypsin, was inferior even to TEG–BA for trypsin inhibition. PMID:28706668

Evaluation Framework for Search Instruments

International Nuclear Information System (INIS)

Warren, Glen A.; Smith, Leon E.; Cooper, Matt W.; Kaye, William R.

2005-01-01

A framework for quantitatively evaluating current and proposed gamma-ray search instrument designs has been developed. The framework is designed to generate a large library of ''virtual neighborhoods'' that can be used to test and evaluate nearly any gamma-ray sensor type. Calculating nuisance-source emissions and combining various sources to create a large number of random virtual scenes places a significant computational burden on the development of the framework. To reduce this burden, a number of radiation transport simplifications have been made which maintain the essential physics ingredients for the quantitative assessment of search instruments while significantly reducing computational times. The various components of the framework, from the simulation and benchmarking of nuisance source emissions to the computational engine for generating the gigabytes of simulated search scenes, are discussed

Portal Vein Embolization Using a Nitinol Plug (Amplatzer Vascular Plug) in Combination with Histoacryl Glue and Iodinized Oil: Adequate Hypertrophy with a Reduced Risk of Nontarget Embolization

International Nuclear Information System (INIS)

Bent, Clare L.; Low, Deborah; Matson, Matthew B.; Renfrew, Ian; Fotheringham, Tim

2009-01-01

The purpose of this study was to assess whether portal vein embolization (PVE) using a nitinol vascular plug in combination with histoacryl glue and iodinized oil minimizes the risk of nontarget embolization while obtaining good levels of future liver remnant (FLR) hypertrophy. Between November 2005 and August 2008, 16 patients (8 females, 8 males; mean age, 63 ± 3.6 years), each with a small FLR, underwent right ipsilateral transhepatic PVE prior to major hepatectomy. Proximal PVE was initially performed by placement of a nitinol vascular plug, followed by distal embolization using a mixture of histoacryl glue and iodinized oil. Pre- and 6 weeks postprocedural FLR volumes were calculated using computed tomographic imaging. Selection for surgery required an FLR of 0.5% of the patient's body mass. Clinical course and outcome of surgical resection for all patients were recorded. At surgery, the ease of hepatectomy was subjectively assessed in comparison to previous experience following PVE with alternative embolic agents. PVE was successful in all patients. Mean procedure time was 30.4 ± 2.5 min. Mean absolute increase in FLR volume was 68.9% ± 12.0% (p = 0.00005). There was no evidence of nontarget embolization during the procedure or on subsequent imaging. Nine patients proceeded to extended hepatectomy. Six patients demonstrated disease progression. One patient did not achieve sufficient hypertrophy in relation to body mass to undergo hepatic resection. At surgery, the hepatobiliary surgeons observed less periportal inflammation compared to previous experience with alternative embolic agents, facilitating dissection at extended hepatectomy. In conclusion, ipsilateral transhepatic PVE using a single nitinol plug in combination with histoacryl glue and iodinized oil simplifies the procedure, offering short procedural times with minimal risk of nontarget embolization. Excellent levels of FLR hypertrophy are achieved enabling safe extended hepatectomy.

Intelligent and robust optimization frameworks for smart grids

Science.gov (United States)

Dhansri, Naren Reddy

A smart grid implies a cyberspace real-time distributed power control system to optimally deliver electricity based on varying consumer characteristics. Although smart grids solve many of the contemporary problems, they give rise to new control and optimization problems with the growing role of renewable energy sources such as wind or solar energy. Under highly dynamic nature of distributed power generation and the varying consumer demand and cost requirements, the total power output of the grid should be controlled such that the load demand is met by giving a higher priority to renewable energy sources. Hence, the power generated from renewable energy sources should be optimized while minimizing the generation from non renewable energy sources. This research develops a demand-based automatic generation control and optimization framework for real-time smart grid operations by integrating conventional and renewable energy sources under varying consumer demand and cost requirements. Focusing on the renewable energy sources, the intelligent and robust control frameworks optimize the power generation by tracking the consumer demand in a closed-loop control framework, yielding superior economic and ecological benefits and circumvent nonlinear model complexities and handles uncertainties for superior real-time operations. The proposed intelligent system framework optimizes the smart grid power generation for maximum economical and ecological benefits under an uncertain renewable wind energy source. The numerical results demonstrate that the proposed framework is a viable approach to integrate various energy sources for real-time smart grid implementations. The robust optimization framework results demonstrate the effectiveness of the robust controllers under bounded power plant model uncertainties and exogenous wind input excitation while maximizing economical and ecological performance objectives. Therefore, the proposed framework offers a new worst-case deterministic

Fibrin glue as the cell-delivery vehicle for mesenchymal stromal cells in regenerative medicine.

Science.gov (United States)

Wu, Xiuwen; Ren, Jianan; Li, Jieshou

2012-05-01

The use of tissue-engineering techniques such as stem-cell therapy to renew injured tissues is a promising strategy in regenerative medicine. As a cell-delivery vehicle, fibrin glues (FG) facilitate cell attachment, growth and differentiation and, ultimately, tissue formation and organization by its three-dimensional structure. Numerous studies have provided evidence that stromal cells derived from bone marrow (bone marrow stromal cells; BMSC) and adipose tissue (adipose-derived stromal cells; ADSC) contain a population of adult multipotent mesenchymal stromal cells (MSC) and endothelial progenitor cells that can differentiate into several lineages. By combining MSC with FG, the implantation could take advantage of the mutual benefits. Researchers and physicians have pinned their hopes on stem cells for developing novel approaches in regenerative medicine. This review focuses on the therapeutic potential of MSC with FG in bone defect reconstruction, cartilage and tendon injury repair, ligament, heart and nerve regeneration, and, furthermore, wound healing.

Experiences with the GLUE information schema in the LCG/EGEE production grid

International Nuclear Information System (INIS)

Burke, S; Andreozzi, S; Field, L

2008-01-01

A common information schema for the description of Grid resources and services is an essential requirement for interoperating Grid infrastructures, and its implementation interacts with every Grid component. In this context, the GLUE information schema was originally defined in 2002 as a joint project between the European DataGrid and DataTAG projects and the US iVDGL. The schema has major components to describe Computing and Storage Elements, and also generic Service and Site information. It has been used extensively in the LCG/EGEE Grid, for job submission, data management, service discovery and monitoring. In this paper we present the experience gained over the last five years, highlighting both successes and problems. In particular, we consider the importance of having a clear definition of schema attributes; the construction of standard information providers and difficulties encountered in mapping an abstract schema to diverse real systems; the configuration of publication in a way which suits system managers and the varying characteristics of Grid sites; the validation of published information; the ways in which information can be used (and misused) by Grid services and users; and issues related to managing schema upgrades in a large distributed system

Generation of political priority for global health initiatives: a framework and case study of maternal mortality.

Science.gov (United States)

Shiffman, Jeremy; Smith, Stephanie

2007-10-13

Why do some global health initiatives receive priority from international and national political leaders whereas others receive little attention? To analyse this question we propose a framework consisting of four categories: the strength of the actors involved in the initiative, the power of the ideas they use to portray the issue, the nature of the political contexts in which they operate, and characteristics of the issue itself. We apply this framework to the case of a global initiative to reduce maternal mortality, which was launched in 1987. We undertook archival research and interviewed people connected with the initiative, using a process-tracing method that is commonly employed in qualitative research. We report that despite two decades of effort the initiative remains in an early phase of development, hampered by difficulties in all these categories. However, the initiative's 20th year, 2007, presents opportunities to build political momentum. To generate political priority, advocates will need to address several challenges, including the creation of effective institutions to guide the initiative and the development of a public positioning of the issue to convince political leaders to act. We use the framework and case study to suggest areas for future research on the determinants of political priority for global health initiatives, which is a subject that has attracted much speculation but little scholarship.

A Systems Engineering Framework for Design, Construction and Operation of the Next Generation Nuclear Plant

International Nuclear Information System (INIS)

Edward J. Gorski; Charles V. Park; Finis H. Southworth

2004-01-01

Not since the International Space Station has a project of such wide participation been proposed for the United States. Ten countries, the European Union, universities, Department of Energy (DOE) laboratories, and industry will participate in the research and development, design, construction and/or operation of the fourth generation of nuclear power plants with a demonstration reactor to be built at a DOE site and operational by the middle of the next decade. This reactor will be like no other. The Next Generation Nuclear Plant (NGNP) will be passively safe, economical, highly efficient, modular, proliferation resistant, and sustainable. In addition to electrical generation, the NGNP will demonstrate efficient and cost effective generation of hydrogen to support the President's Hydrogen Initiative. To effectively manage this multi-organizational and technologically complex project, systems engineering techniques and processes will be used extensively to ensure delivery of the final product. The technological and organizational challenges are complex. Research and development activities are required, material standards require development, hydrogen production, storage and infrastructure requirements are not well developed, and the Nuclear Regulatory Commission may further define risk-informed/performance-based approach to licensing. Detailed design and development will be challenged by the vast cultural and institutional differences across the participants. Systems engineering processes must bring the technological and organizational complexity together to ensure successful product delivery. This paper will define the framework for application of systems engineering to this $1.5B - $1.9B project

Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

Science.gov (United States)

Wadley, Lyn; Trower, Gary; Backwell, Lucinda; d'Errico, Francesco

2015-01-01

Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone Age sites of Diepkloof

Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

Directory of Open Access Journals (Sweden)

Lyn Wadley

Full Text Available Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone

Valuation-Based Framework for Considering Distributed Generation Photovoltaic Tariff Design: Preprint

Energy Technology Data Exchange (ETDEWEB)

Zinaman, O. R.; Darghouth, N. R.

2015-02-01

While an export tariff is only one element of a larger regulatory framework for distributed generation, we choose to focus on tariff design because of the significant impact this program design component has on the various flows of value among power sector stakeholders. In that context, this paper is organized into a series of steps that can be taken during the design of a DGPV export tariff design. To that end this paper outlines a holistic, high-level approach to the complex undertaking of DGPV tariff design, the crux of which is an iterative cost-benefit analysis process. We propose a multi-step progression that aims to promote transparent, focused, and informed dialogue on CBA study methodologies and assumptions. When studies are completed, the long-run marginal avoided cost of the DGPV program should be compared against the costs imposed on utilities and non-participating customers, recognizing that these can be defined differently depending on program objectives. The results of this comparison can then be weighed against other program objectives to formulate tariff options. Potential changes to tariff structures can be iteratively fed back into established analytical tools to inform further discussions.

Dye-sensitized MIL-101 metal organic frameworks loaded with Ni/NiOx nanoparticles for efficient visible-light-driven hydrogen generation

Directory of Open Access Journals (Sweden)

Xin-Ling Liu

2015-10-01

Full Text Available The Ni/NiOx particles were in situ photodeposited on MIL-101 metal organic frameworks as catalysts for boosting H2 generation from Erythrosin B dye sensitization under visible-light irradiation. The highest H2 production rate of 125 μmol h−1 was achieved from the system containing 5 wt. % Ni-loaded MIL-101 (20 mg and 30 mg Erythrosin B dye. Moreover, the Ni/NiOx catalysts show excellent stability for long-term photocatalytic reaction. The enhancement on H2 generation is attributed to the efficient charge transfer from photoexcited dye to the Ni catalyst via MIL-101. Our results demonstrate that the economical Ni/NiOx particles are durable and active catalysts for photocatalytic H2 generation.

蛋白胶-罂粟碱复合体促进调Q Nd:YAG激光治疗后创面愈合的观察%Using Fibrin Glue Papaverine Complex to Promote Wounds Healing after Q-Switched Laser

Institute of Scientific and Technical Information of China (English)

朱玉; 李栋梁; 陈志勇; 谭强; 周业松

2011-01-01

目的 观察蛋白胶-罂粟碱复合体对调Q Nd:YAG激光治疗后创面愈合的促进作用.方法 太田痣患者50例,随机分为研究组和对照组,每组25例.以调Q Nd:YAG激光治疗后,分别应用蛋白胶-罂粟碱复合体或凡士林纱布覆盖创面,对比观察两组患者创面疼痛评分、止血时间及愈合时间.结果 研究组在创面疼痛评分、止血时间、创面愈合时间均优于对照组.结论 蛋白胶-罂粟碱复合体对调Q Nd:YAG激光治疗后的创面具有明显的减轻疼痛,促进愈合的作用.%Objective To observe the effects of using fibrin glue papaverine complex to promote wound healing after Q-switched laser therapy.Methods Fifty patients with nevus of Ota were randomly and equally assigned to two groupa: the study group applied fibrin glue papaverine complex and the control group applied vaseline gauze,and their wounds pain, hemostatic lime and healing time were compared.Results Covering wounds with glue papaverine complex after Q-switched laser was superior to the other therapy from aspects of pain alleviation, hemostatic time and healing time.Conclusions Covering wounds with glue papaverine complex after the treatment of Q-switched laser can alleviate the pain and accelerate the wound healing.

Encephalopathy and Neuropathy due to Glue, Paint Thinner, and Gasoline Sniffing in Trinidad and Tobago-MRI Findings

Directory of Open Access Journals (Sweden)

Kanterpersad Ramcharan

2014-01-01

Full Text Available A 29-year-old male petrol station pump attendant was admitted with ataxia and clinical evidence of a sensorimotor polyneuropathy which developed over the preceding 3 months. He had cognitive dysfunction, hearing loss, and cerebellar clinical abnormalities that came on slowly over the three years. He had a fifteen-year history of sniffing mostly glue, occasionally paint thinners, and, in the recent two years, gasoline. Magnetic resonance brain imaging showed abnormalities of the cerebral cortex, cerebral white matter, corpus callosum, hippocampus, brainstem and cerebellar atrophy, hypointensities of basal ganglia, red nuclei, and substantia nigra as previously described in toluene sniffing. Abstinence for six months led to partial clinical improvement. Clinicians need to be aware of this preventable entity which has peculiar radiological findings which are being increasingly accepted as typical.

Calibrations for charged particle tracking and measurements of w photoproduction with the GlueX detector

Energy Technology Data Exchange (ETDEWEB)

Staib, Michael [Carnegie Mellon Univ., Pittsburgh, PA (United States)

2017-09-21

The GlueX experiment is a new experimental facility at Jefferson Lab in Newport News, VA. The experiment aims to map out the spectrum of hybrid mesons in the light quark sector. Measurements of the spin-density matrix elements in omega photoproduction are performed with a linear polarized photon beam on an unpolarized proton target, and presented in bins of Mandelstam t for beam energies of 8.4-9.0 GeV. The spin-density matrix elements are exclusively measured through two decays of the omega meson: omega -> pi^+ pi^- pi^0 and omega ->pi^0 gamma. A description of the experimental apparatus is presented. Several methods used in the calibration of the charged particle tracking system are described. These measurements greatly improve the world statistics in this energy range. These are the first results measured through the omega ->pi^0 gamma decay at this energy. Results are generally consistent with a theoretical model based on diffractive production with Pomeron and pseudoscalar exchange in the t-channel.

Fabrication of ceramic oxide-coated SWNT composites by sol–gel process with a polymer glue

International Nuclear Information System (INIS)

Zhang Cheng; Gao Lei; Chen Yongming

2011-01-01

The functional copolymer bearing alkoxysilyl and pyrene groups, poly[3-(triethoxysilyl)propyl methacrylate]-co-[(1-pyrene-methyl) methacrylate] (TEPM 13 -co-PyMMA 3 ), was synthesized via atom transfer radical polymerization. Attributing the π–π interaction of pyrene units with the walls of single-walled carbon nanotubes (SWNTs), this polymer could disperse and exfoliate SWNTs in different solvents through physical interaction as demonstrated by TEM, UV/Vis absorption, and FT-IR analysis. The alkoxysilyl groups functionalized SWNTs were reacted with different inorganic precursors via sol–gel reaction, and, as a results, silica, titania, and alumina were coated onto the surface of SWNTs, respectively via copolymers as a molecular glue. The nanocomposites of ceramic oxides/SWNTs were characterized by SEM analysis. Dependent upon the feed, the thickness of inorganic coating can be tuned easily. This study supplies a facile and general way to coat SWNTs with ceramic oxides without deteriorating the properties of pristine SWNTs.

Comparison of a plasma-based composite biologic sealant with fibrin glue (Tisseel) for vascular anastomoses.

Science.gov (United States)

Doillon, Charles J; Dion, Yves-Marie

2004-12-01

Biologic sealants are needed in numerous, more and more demanding, procedures--especially with developments occurring in endovascular and laparoscopic vascular techniques. An initial pilot study in dogs showed that a 4-cm aortotomy closed with a polyester patch sutured in place by a 4-mm-spaced running suture consistently led to massive hemorrhage. We then designed a study using five dogs where two aortotomies were done to compare the effect of Tisseel to that of an autologous sealant prepared in our laboratory. Arterial pressures and heparinization were maintained throughout the surgical procedure. Both biologic sealants prevented hemorrhage from the arteriotomy at unclamping. Macroscopic and histologic assessments were performed. At killing, one week later, the autologous sealant exhibited less blood saturation of the collagen sponge compared with Tisseel. The use of autologous plasma combined with other adhesive components could be an efficient alternative to allogenic fibrin glue. Further studies are needed to confirm these observations.

Fabrication of ceramic oxide-coated SWNT composites by sol-gel process with a polymer glue

Science.gov (United States)

Zhang, Cheng; Gao, Lei; Chen, Yongming

2011-09-01

The functional copolymer bearing alkoxysilyl and pyrene groups, poly[3-(triethoxysilyl)propyl methacrylate]- co-[(1-pyrene-methyl) methacrylate] (TEPM13- co-PyMMA3), was synthesized via atom transfer radical polymerization. Attributing the π-π interaction of pyrene units with the walls of single-walled carbon nanotubes (SWNTs), this polymer could disperse and exfoliate SWNTs in different solvents through physical interaction as demonstrated by TEM, UV/Vis absorption, and FT-IR analysis. The alkoxysilyl groups functionalized SWNTs were reacted with different inorganic precursors via sol-gel reaction, and, as a results, silica, titania, and alumina were coated onto the surface of SWNTs, respectively via copolymers as a molecular glue. The nanocomposites of ceramic oxides/SWNTs were characterized by SEM analysis. Dependent upon the feed, the thickness of inorganic coating can be tuned easily. This study supplies a facile and general way to coat SWNTs with ceramic oxides without deteriorating the properties of pristine SWNTs.

Nd:YAG laser double wavelength ablation of pollution encrustation on marble and bonding glues on duplicated painting canvas

Science.gov (United States)

Batishche, Sergei; Englezis, Apostolis; Gorovets, Tatiana; Kouzmouk, Andrei; Pilipenka, Uladzimir; Pouli, Paraskevi; Tatur, Hennady; Totou, Garyfallia; Ukhau, Viktar

2005-07-01

In the present study, a newly developed one-beam IR-UV laser cleaning system is presented. This system may be used for different applications in diverse fields, such as outdoors stonework conservation and canvas paintings restoration. The simultaneous use of the fundamental radiation of a Q-switched Nd:YAG laser at 1064 nm and its third harmonic at 355 nm was found appropriate to clean pollution crusts, while ensuring that no discoloration ("yellowing") would occur. The optimum ratio of UV to IR wavelengths in the final cleaning beam was investigated. In parallel, the same system was tested in diverse applications, such as the removal of bonding glues from duplicated canvases. The optimum laser parameters were investigated both on technical samples as well as on original paintings.

Society, Land, Love or Money (A Strategic Model of How to Glue the Generations Together),

Science.gov (United States)

1981-01-01

carrying of extra capital stock. 33 REFERENCES Dawkins , R. (1976), The Selfish Gene . New York: Oxford University Press. Dubey, P. and N. Shubik (1981...a gene would rapidly disappear. The care for offspring needs to be forthcoming until the last of the new generation is selfsufficient and able to...payoff than the firs:. it is more complicated. 20 4.3. Selfish Individuals and Threat Strategies (Model 1) In this section an example is fully

An Agent Framework of Tourism Recommender System

Directory of Open Access Journals (Sweden)

Jia Zhi Yang

2016-01-01

Full Text Available This paper proposes the development of an Agent framework for tourism recommender system. The recommender system can be featured as an online web application which is capable of generating a personalized list of preference attractions for tourists. Traditional technologies of classical recommender system application domains, such as collaborative filtering, content-based filtering and content-based filtering are effectively adopted in the framework. In the framework they are constructed as Agents that can generate recommendations respectively. Recommender Agent can generate recommender information by integrating the recommendations of Content-based Agent, collaborative filtering-based Agent and constraint-based Agent. In order to make the performance more effective, linear combination method of data fusion is applied. User interface is provided by the tourist Agent in form of webpages and mobile app.

Protocol Implementation Generator

DEFF Research Database (Denmark)

Carvalho Quaresma, Jose Nuno; Probst, Christian W.

2010-01-01

Users expect communication systems to guarantee, amongst others, privacy and integrity of their data. These can be ensured by using well-established protocols; the best protocol, however, is useless if not all parties involved in a communication have a correct implementation of the protocol and a...... Generator framework based on the LySatool and a translator from the LySa language into C or Java....... necessary tools. In this paper, we present the Protocol Implementation Generator (PiG), a framework that can be used to add protocol generation to protocol negotiation, or to easily share and implement new protocols throughout a network. PiG enables the sharing, verification, and translation...

A distributed big data storage and data mining framework for solar-generated electricity quantity forecasting

Science.gov (United States)

Wang, Jianzong; Chen, Yanjun; Hua, Rui; Wang, Peng; Fu, Jia

2012-02-01

Photovoltaic is a method of generating electrical power by converting solar radiation into direct current electricity using semiconductors that exhibit the photovoltaic effect. Photovoltaic power generation employs solar panels composed of a number of solar cells containing a photovoltaic material. Due to the growing demand for renewable energy sources, the manufacturing of solar cells and photovoltaic arrays has advanced considerably in recent years. Solar photovoltaics are growing rapidly, albeit from a small base, to a total global capacity of 40,000 MW at the end of 2010. More than 100 countries use solar photovoltaics. Driven by advances in technology and increases in manufacturing scale and sophistication, the cost of photovoltaic has declined steadily since the first solar cells were manufactured. Net metering and financial incentives, such as preferential feed-in tariffs for solar-generated electricity; have supported solar photovoltaics installations in many countries. However, the power that generated by solar photovoltaics is affected by the weather and other natural factors dramatically. To predict the photovoltaic energy accurately is of importance for the entire power intelligent dispatch in order to reduce the energy dissipation and maintain the security of power grid. In this paper, we have proposed a big data system--the Solar Photovoltaic Power Forecasting System, called SPPFS to calculate and predict the power according the real-time conditions. In this system, we utilized the distributed mixed database to speed up the rate of collecting, storing and analysis the meteorological data. In order to improve the accuracy of power prediction, the given neural network algorithm has been imported into SPPFS.By adopting abundant experiments, we shows that the framework can provide higher forecast accuracy-error rate less than 15% and obtain low latency of computing by deploying the mixed distributed database architecture for solar-generated electricity.

Self generation, small generation, and embedded generation issues

International Nuclear Information System (INIS)

2001-01-01

The New Brunswick Market Design Committee for electric power restructuring has been directed to examine issues regarding cogeneration and small-scale, on-site generation and how they will fit within the framework of the bilateral contract market. The Committee will also have to deal with issues of generation embedded in a distribution system. The Committee has defined cogeneration as the simultaneous production of electricity and useful thermal energy. Self-generation has been defined as small-scale power generation by an end-user, while embedded generation has been defined as a generation facility that is located within a distribution utility but is not directly connected to the transmission system. The Committee has postponed its decision on whether embedded generation will be eligible to participate under the bilateral contract market for electricity. This report discusses general issues such as the physical support of generation, market support of generation, transition issues and policy issues. It also discusses generation support issues such as operating reserves, transmission tariff issues, and distribution tariffs. Market support issues such as transmission access for generation sales were also considered, along with market access for generation sales, and net metering for behind the meter generation. 7 refs., 1 tab

BCube: A Broker Framework for Next Generation Geoscience

Science.gov (United States)

Khalsa, S. S.; Pearlman, J.; Nativi, S.

2013-12-01

EarthCube is an NSF initiative that aims to transform the conduct of research through the creation of community-guided cyberinfrastructure enabling the integration information and data across the geosciences. Following an initial phase of concept and community development activities, NSF has made awards for the development of cyberinfrastructure 'building blocks.' In this talk we describe the goals and methods for one of these projects - BCube, for Brokering Building Blocks. BCube addresses the need for effective and efficient multi-disciplinary collaboration and interoperability through the introduction of brokering technologies. Brokers, as information systems middleware, have existed for many years and are found in diverse domains and industries such as financial systems, business-to-business interfaces, medicine and the automotive industry, to name a few. However, the emergence of brokers in science is relatively new and is now being piloted with great promise in cyberinfrastructure and science communities in the U.S., Europe, and elsewhere. Brokers act as intermediaries between information systems that implement well-defined interfaces, providing a bridge between communities using different specifications. The BCube project is helping to build a truly cross-disciplinary, global platform for data providers, cyberinfrastructure developers, and data users to make data more available and interoperable through a brokering framework. Building on the GEOSS Discover and Access Broker (DAB), BCube will develop new modules and services including * Expanded semantic brokering * Business Model support for work flows * Automated metadata generation * Automated linking to services discovered via web crawling * Plug and play for most community service buses * Credential passing for seamless access to data * Ranking of search results from brokered catalogs Because facilitating cross-discipline research involves cultural and well as technical challenges, BCube is also

Next generation framework for aquatic modeling of the Earth System

Science.gov (United States)

Fekete, B. M.; Wollheim, W. M.; Wisser, D.; Vörösmarty, C. J.

2009-03-01

Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES) have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc.) as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities. NextFrAMES was designed primarily for

Risk management frameworks: supporting the next generation of Murray-Darling Basin water sharing plans

Directory of Open Access Journals (Sweden)

G. M. Podger

2014-09-01

Full Text Available Water jurisdictions in Australia are required to prepare and implement water resource plans. In developing these plans the common goal is realising the best possible use of the water resources – maximising outcomes while minimising negative impacts. This requires managing the risks associated with assessing and balancing cultural, industrial, agricultural, social and environmental demands for water within a competitive and resource-limited environment. Recognising this, conformance to international risk management principles (ISO 31000:2009 have been embedded within the Murray-Darling Basin Plan. Yet, to date, there has been little strategic investment by water jurisdictions in bridging the gap between principle and practice. The ISO 31000 principles and the risk management framework that embodies them align well with an adaptive management paradigm within which to conduct water resource planning. They also provide an integrative framework for the development of workflows that link risk analysis with risk evaluation and mitigation (adaptation scenarios, providing a transparent, repeatable and robust platform. This study, through a demonstration use case and a series of workflows, demonstrates to policy makers how these principles can be used to support the development of the next generation of water sharing plans in 2019. The workflows consider the uncertainty associated with climate and flow inputs, and model parameters on irrigation and hydropower production, meeting environmental flow objectives and recreational use of the water resource. The results provide insights to the risks associated with meeting a range of different objectives.

SAIL: A Framework for Promoting Next-Generation Word Study

Science.gov (United States)

Ganske, Kathy

2016-01-01

This article introduces SAIL, an instructional framework designed to help teachers optimize students' learning during small-group word study instruction. Small-group word study interactions afford opportunities for teachers to engage students in thinking, talking, advancing vocabulary knowledge (including general academic vocabulary), and making…

Probabilistic Models and Generative Neural Networks: Towards an Unified Framework for Modeling Normal and Impaired Neurocognitive Functions.

Science.gov (United States)

Testolin, Alberto; Zorzi, Marco

2016-01-01

Connectionist models can be characterized within the more general framework of probabilistic graphical models, which allow to efficiently describe complex statistical distributions involving a large number of interacting variables. This integration allows building more realistic computational models of cognitive functions, which more faithfully reflect the underlying neural mechanisms at the same time providing a useful bridge to higher-level descriptions in terms of Bayesian computations. Here we discuss a powerful class of graphical models that can be implemented as stochastic, generative neural networks. These models overcome many limitations associated with classic connectionist models, for example by exploiting unsupervised learning in hierarchical architectures (deep networks) and by taking into account top-down, predictive processing supported by feedback loops. We review some recent cognitive models based on generative networks, and we point out promising research directions to investigate neuropsychological disorders within this approach. Though further efforts are required in order to fill the gap between structured Bayesian models and more realistic, biophysical models of neuronal dynamics, we argue that generative neural networks have the potential to bridge these levels of analysis, thereby improving our understanding of the neural bases of cognition and of pathologies caused by brain damage.

Promoting Healthy Child Development via a Two-Generation Translational Neuroscience Framework: The Filming Interactions to Nurture Development Video Coaching Program.

Science.gov (United States)

Fisher, Philip A; Frenkel, Tahl I; Noll, Laura K; Berry, Melanie; Yockelson, Melissa

2016-12-01

In this article, we focus on applying methods of translational neuroscience to two-generation, family-based interventions. In recent years, a small but growing body of evidence has documented the reversibility of some of the neurobiological effects of early adversity in the context of environmental early interventions. Some of these interventions are now being implemented at scale, which may help reduce disparities in the face of early life stress. Further progress may occur by extending these efforts to two-generation models that target caregivers' capabilities to improve children's outcomes. In this article, we describe the content and processes of the Filming Interactions to Nurture Development (FIND) video coaching intervention. We also discuss the two-generation, translational neuroscience framework on which FIND is based, and how similar approaches can be developed and scaled to mitigate the effects of adversity.

Phenotype Instance Verification and Evaluation Tool (PIVET): A Scaled Phenotype Evidence Generation Framework Using Web-Based Medical Literature

Science.gov (United States)

Ke, Junyuan; Ho, Joyce C; Ghosh, Joydeep; Wallace, Byron C

2018-01-01

Background Researchers are developing methods to automatically extract clinically relevant and useful patient characteristics from raw healthcare datasets. These characteristics, often capturing essential properties of patients with common medical conditions, are called computational phenotypes. Being generated by automated or semiautomated, data-driven methods, such potential phenotypes need to be validated as clinically meaningful (or not) before they are acceptable for use in decision making. Objective The objective of this study was to present Phenotype Instance Verification and Evaluation Tool (PIVET), a framework that uses co-occurrence analysis on an online corpus of publically available medical journal articles to build clinical relevance evidence sets for user-supplied phenotypes. PIVET adopts a conceptual framework similar to the pioneering prototype tool PheKnow-Cloud that was developed for the phenotype validation task. PIVET completely refactors each part of the PheKnow-Cloud pipeline to deliver vast improvements in speed without sacrificing the quality of the insights PheKnow-Cloud achieved. Methods PIVET leverages indexing in NoSQL databases to efficiently generate evidence sets. Specifically, PIVET uses a succinct representation of the phenotypes that corresponds to the index on the corpus database and an optimized co-occurrence algorithm inspired by the Aho-Corasick algorithm. We compare PIVET’s phenotype representation with PheKnow-Cloud’s by using PheKnow-Cloud’s experimental setup. In PIVET’s framework, we also introduce a statistical model trained on domain expert–verified phenotypes to automatically classify phenotypes as clinically relevant or not. Additionally, we show how the classification model can be used to examine user-supplied phenotypes in an online, rather than batch, manner. Results PIVET maintains the discriminative power of PheKnow-Cloud in terms of identifying clinically relevant phenotypes for the same corpus with

Aspects for Run-time Component Integration

DEFF Research Database (Denmark)

Truyen, Eddy; Jørgensen, Bo Nørregaard; Joosen, Wouter

2000-01-01

Component framework technology has become the cornerstone of building a family of systems and applications. A component framework defines a generic architecture into which specialized components can be plugged. As such, the component framework leverages the glue that connects the different inserted...... to dynamically integrate into the architecture of middleware systems new services that support non-functional aspects such as security, transactions, real-time....

Koopman Operator Framework for Time Series Modeling and Analysis

Science.gov (United States)

Surana, Amit

2018-01-01

We propose an interdisciplinary framework for time series classification, forecasting, and anomaly detection by combining concepts from Koopman operator theory, machine learning, and linear systems and control theory. At the core of this framework is nonlinear dynamic generative modeling of time series using the Koopman operator which is an infinite-dimensional but linear operator. Rather than working with the underlying nonlinear model, we propose two simpler linear representations or model forms based on Koopman spectral properties. We show that these model forms are invariants of the generative model and can be readily identified directly from data using techniques for computing Koopman spectral properties without requiring the explicit knowledge of the generative model. We also introduce different notions of distances on the space of such model forms which is essential for model comparison/clustering. We employ the space of Koopman model forms equipped with distance in conjunction with classical machine learning techniques to develop a framework for automatic feature generation for time series classification. The forecasting/anomaly detection framework is based on using Koopman model forms along with classical linear systems and control approaches. We demonstrate the proposed framework for human activity classification, and for time series forecasting/anomaly detection in power grid application.

Generative Semantics.

Science.gov (United States)

King, Margaret

The first section of this paper deals with the attempts within the framework of transformational grammar to make semantics a systematic part of linguistic description, and outlines the characteristics of the generative semantics position. The second section takes a critical look at generative semantics in its later manifestations, and makes a case…

RenderGAN: Generating Realistic Labeled Data

Directory of Open Access Journals (Sweden)

Leon Sixt

2018-06-01

Full Text Available Deep Convolutional Neuronal Networks (DCNNs are showing remarkable performance on many computer vision tasks. Due to their large parameter space, they require many labeled samples when trained in a supervised setting. The costs of annotating data manually can render the use of DCNNs infeasible. We present a novel framework called RenderGAN that can generate large amounts of realistic, labeled images by combining a 3D model and the Generative Adversarial Network framework. In our approach, image augmentations (e.g., lighting, background, and detail are learned from unlabeled data such that the generated images are strikingly realistic while preserving the labels known from the 3D model. We apply the RenderGAN framework to generate images of barcode-like markers that are attached to honeybees. Training a DCNN on data generated by the RenderGAN yields considerably better performance than training it on various baselines.

Fuzziness-based active learning framework to enhance hyperspectral image classification performance for discriminative and generative classifiers.

Directory of Open Access Journals (Sweden)

Muhammad Ahmad

Full Text Available Hyperspectral image classification with a limited number of training samples without loss of accuracy is desirable, as collecting such data is often expensive and time-consuming. However, classifiers trained with limited samples usually end up with a large generalization error. To overcome the said problem, we propose a fuzziness-based active learning framework (FALF, in which we implement the idea of selecting optimal training samples to enhance generalization performance for two different kinds of classifiers, discriminative and generative (e.g. SVM and KNN. The optimal samples are selected by first estimating the boundary of each class and then calculating the fuzziness-based distance between each sample and the estimated class boundaries. Those samples that are at smaller distances from the boundaries and have higher fuzziness are chosen as target candidates for the training set. Through detailed experimentation on three publically available datasets, we showed that when trained with the proposed sample selection framework, both classifiers achieved higher classification accuracy and lower processing time with the small amount of training data as opposed to the case where the training samples were selected randomly. Our experiments demonstrate the effectiveness of our proposed method, which equates favorably with the state-of-the-art methods.

Development of a framework for the neutorinics analysis system for next generation (2) (Contract research)

International Nuclear Information System (INIS)

Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro; Jin, Tomoyuki; Yokoyama, Kenji

2008-10-01

Japan Atomic Energy Agency promotes development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of prototype reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation system provides solutions to the following requirements: (1) Flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative assurance of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality assurance and development efficiency. There has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. In order to solve this problem, a policy of the hybrid system is adopted for the next-generation system, in which a controlling part is implemented in the scripting language with rich flexibility and maintainability and solution kernels that requires execution speed in the system language. In this study, detailed design of a framework, its implementation and tests are conducted so that a Python system layer can drive calculation codes written in C++ and/or Fortran. It is confirmed that various type of calculation codes such as diffusion, transport and burnup codes can be treated in the same manner on the platform for unified management system for calculation codes with a data exchange mechanism for abstracted data model between the Python and the calculation code layers. (author)

Pythoscape: A framework for generation of large protein similarity networks

OpenAIRE

Babbitt, Patricia; Barber, AE; Babbitt, PC

2012-01-01

Pythoscape is a framework implemented in Python for processing large protein similarity networks for visualization in other software packages. Protein similarity networks are graphical representations of sequence, structural and other similarities among pr

a Conceptual Framework for Indoor Mapping by Using Grammars

Science.gov (United States)

Hu, X.; Fan, H.; Zipf, A.; Shang, J.; Gu, F.

2017-09-01

Maps are the foundation of indoor location-based services. Many automatic indoor mapping approaches have been proposed, but they rely highly on sensor data, such as point clouds and users' location traces. To address this issue, this paper presents a conceptual framework to represent the layout principle of research buildings by using grammars. This framework can benefit the indoor mapping process by improving the accuracy of generated maps and by dramatically reducing the volume of the sensor data required by traditional reconstruction approaches. In addition, we try to present more details of partial core modules of the framework. An example using the proposed framework is given to show the generation process of a semantic map. This framework is part of an ongoing research for the development of an approach for reconstructing semantic maps.

Development of the Tagger Microscope & Analysis of Spin Density Matrix Elements in gamma-p -> phi-p for the GlueX Experiment

Energy Technology Data Exchange (ETDEWEB)

Barnes, Alexander E. [Carnegie Mellon Univ., Pittsburgh, PA (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

2017-05-31

The quark model has been successful in classifying the spectrum of mesons observed since the 1960s, however, it fails to explain some of the measured bound states. Lattice QCD predictions have shown that an excited gluonic field may contribute to the quantum numbers of the bound state and form hybrid mesons, qq-bar-g, where g is a constituent gluon. It is possible for some hybrids to possess quantum numbers forbidden by the quark model and are known as \\smoking gun" hybrids due to their lack of mixing with conventional qq-bar states. The GlueX photoproduction experiment at Jefferson Lab in Newport News, VA is designed to study hybrid mesons and to map their spectrum. A 12 GeV electron beam produces 9 GeV linearly polarized photons via coherent bremsstrahlung in a diamond radiator which are incident on a liquid H2 target. In order to determine the photon energy, the use of a tagging spectrometer which measures the energy of the post-bremsstrahlung electron is required. The tagger microscope is a scintillating fiber detector designed to measure the energy of electrons corresponding to the polarized photons. The main focus of this work is the design and construction of the tagger microscope electronics as well as the calibration of the microscope within the experiment. Additionally, the analysis of the reaction gamma-p -> phi-p, where phi (1020) -> K+K-, is discussed. This analysis provides a high-level calibration for GlueX in regards to understanding the acceptance and sensitivity of the detectors to mesons with strange quark content. By studying the phi with linearly polarized photons, information on the production mechanism can be extracted. The measurement of the phi spin-density matrix elements are shown and compared with past data which are found to be in agreement.

Risk perception & strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy.

Energy Technology Data Exchange (ETDEWEB)

Brewer, Jeffrey D.

2005-11-01

The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate the wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system.

A Parametric Empirical Bayesian framework for the EEG/MEG inverse problem: generative models for multisubject and multimodal integration

Directory of Open Access Journals (Sweden)

Richard N Henson

2011-08-01

Full Text Available We review recent methodological developments within a Parametric Empirical Bayesian (PEB framework for reconstructing intracranial sources of extracranial electroencephalographic (EEG and magnetoencephalographic (MEG data under linear Gaussian assumptions. The PEB framework offers a natural way to integrate multiple constraints (spatial priors on this inverse problem, such as those derived from different modalities (e.g., from functional magnetic resonance imaging, fMRI or from multiple replications (e.g., subjects. Using variations of the same basic generative model, we illustrate the application of PEB to three cases: 1 symmetric integration (fusion of MEG and EEG; 2 asymmetric integration of MEG or EEG with fMRI, and 3 group-optimisation of spatial priors across subjects. We evaluate these applications on multimodal data acquired from 18 subjects, focusing on energy induced by face perception within a time-frequency window of 100-220ms, 8-18Hz. We show the benefits of multi-modal, multi-subject integration in terms of the model evidence and the reproducibility (over subjects of cortical responses to faces.

A CONCEPTUAL FRAMEWORK FOR INDOOR MAPPING BY USING GRAMMARS

Directory of Open Access Journals (Sweden)

X. Hu

2017-09-01

Full Text Available Maps are the foundation of indoor location-based services. Many automatic indoor mapping approaches have been proposed, but they rely highly on sensor data, such as point clouds and users’ location traces. To address this issue, this paper presents a conceptual framework to represent the layout principle of research buildings by using grammars. This framework can benefit the indoor mapping process by improving the accuracy of generated maps and by dramatically reducing the volume of the sensor data required by traditional reconstruction approaches. In addition, we try to present more details of partial core modules of the framework. An example using the proposed framework is given to show the generation process of a semantic map. This framework is part of an ongoing research for the development of an approach for reconstructing semantic maps.

Dye-sensitized MIL-101 metal organic frameworks loaded with Ni/NiO{sub x} nanoparticles for efficient visible-light-driven hydrogen generation

Energy Technology Data Exchange (ETDEWEB)

Liu, Xin-Ling; Wang, Rong; Yuan, Yu-Peng, E-mail: yupengyuan@ahu.edu.cn, E-mail: cxue@ntu.edu.sg [School of Chemistry and Chemical Engineering, and Innovation Lab for Clean Energy and Green Catalysis, Anhui University, Hefei 230036 (China); Zhang, Ming-Yi [Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin 150025 (China); Xue, Can, E-mail: yupengyuan@ahu.edu.cn, E-mail: cxue@ntu.edu.sg [Solar Fuels Lab, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore)

2015-10-01

The Ni/NiO{sub x} particles were in situ photodeposited on MIL-101 metal organic frameworks as catalysts for boosting H{sub 2} generation from Erythrosin B dye sensitization under visible-light irradiation. The highest H{sub 2} production rate of 125 μmol h{sup −1} was achieved from the system containing 5 wt. % Ni-loaded MIL-101 (20 mg) and 30 mg Erythrosin B dye. Moreover, the Ni/NiO{sub x} catalysts show excellent stability for long-term photocatalytic reaction. The enhancement on H{sub 2} generation is attributed to the efficient charge transfer from photoexcited dye to the Ni catalyst via MIL-101. Our results demonstrate that the economical Ni/NiO{sub x} particles are durable and active catalysts for photocatalytic H{sub 2} generation.

Phenotype Instance Verification and Evaluation Tool (PIVET): A Scaled Phenotype Evidence Generation Framework Using Web-Based Medical Literature.

Science.gov (United States)

Henderson, Jette; Ke, Junyuan; Ho, Joyce C; Ghosh, Joydeep; Wallace, Byron C

2018-05-04

Researchers are developing methods to automatically extract clinically relevant and useful patient characteristics from raw healthcare datasets. These characteristics, often capturing essential properties of patients with common medical conditions, are called computational phenotypes. Being generated by automated or semiautomated, data-driven methods, such potential phenotypes need to be validated as clinically meaningful (or not) before they are acceptable for use in decision making. The objective of this study was to present Phenotype Instance Verification and Evaluation Tool (PIVET), a framework that uses co-occurrence analysis on an online corpus of publically available medical journal articles to build clinical relevance evidence sets for user-supplied phenotypes. PIVET adopts a conceptual framework similar to the pioneering prototype tool PheKnow-Cloud that was developed for the phenotype validation task. PIVET completely refactors each part of the PheKnow-Cloud pipeline to deliver vast improvements in speed without sacrificing the quality of the insights PheKnow-Cloud achieved. PIVET leverages indexing in NoSQL databases to efficiently generate evidence sets. Specifically, PIVET uses a succinct representation of the phenotypes that corresponds to the index on the corpus database and an optimized co-occurrence algorithm inspired by the Aho-Corasick algorithm. We compare PIVET's phenotype representation with PheKnow-Cloud's by using PheKnow-Cloud's experimental setup. In PIVET's framework, we also introduce a statistical model trained on domain expert-verified phenotypes to automatically classify phenotypes as clinically relevant or not. Additionally, we show how the classification model can be used to examine user-supplied phenotypes in an online, rather than batch, manner. PIVET maintains the discriminative power of PheKnow-Cloud in terms of identifying clinically relevant phenotypes for the same corpus with which PheKnow-Cloud was originally developed, but

Emotion-driven level generation

OpenAIRE

Togelius, Julian; Yannakakis, Georgios N.

2016-01-01

This chapter examines the relationship between emotions and level generation. Grounded in the experience-driven procedural content generation framework we focus on levels and introduce a taxonomy of approaches for emotion-driven level generation. We then review four characteristic level generators of our earlier work that exemplify each one of the approaches introduced. We conclude the chapter with our vision on the future of emotion-driven level generation.

Endolymphatic Ethiodized Oil Intranodal Lymphangiography and Cyanoacrylate Glue Embolization for the Treatment of Postoperative Lymphatic Leak After Robot-Assisted Laparoscopic Pelvic Resection.

Science.gov (United States)

Hill, Hannah; Srinivasa, Ravi N; Gemmete, Joseph J; Hage, Anthony; Bundy, Jacob; Chick, Jeffrey Forris Beecham

2018-01-01

Purpose: To report the approach, technical success, clinical outcomes, complications, and follow-up of ethiodized oil intranodal lymphangiography with cyanoacrylate glue embolization for the treatment of lymphatic leak after robot-assisted laparoscopic pelvic resection. Materials and Methods: Four men with mean age 68.7 ± 14.3 years were treated with ethiodized oil intranodal lymphangiography with cyanoacrylate embolization for postoperative lymphatic leak. Patients underwent either (1) cystoprostatectomy with ileal conduit and bilateral extensive pelvic lymph node dissection for muscle-invasive urothelial carcinoma and presented with postoperative lymphatic ascites ( n  = 2) or (2) prostatectomy with bilateral standard pelvic lymph node dissection for prostate carcinoma and presented with postoperative pelvic lymphoceles ( n  = 2). Intranodal lymphangiography and embolization procedural details, technical success, clinical outcomes, and follow-up were recorded. Results: In four patients, a total of six ethiodized oil intranodal lymphangiograms were performed, two procedures being repeated interventions. Inguinal lymph node catheterization and ethiodized oil lymphangiography was technically effective in all procedures. A mean of 5.2 ± 2.0 mL of ethiodized oil was used for lymphatic opacification. Cyanoacrylate was diluted to 24.2% with ethiodized oil and 0.44 mL of cyanoacrylate was instilled during first time interventions. On repeat procedures, cyanoacrylate was diluted to 51.7%, and 0.52 mL was instilled. The primary clinical success rate was 50% ( n  = 2/4). Clinical success was achieved in all patients after two interventions ( n  = 4; 100%). No complications were reported at mean follow-up of 134.7 ± 79.2 days (range: 59-248 days). Conclusion: Ethiodized oil intranodal lymphangiography with direct cyanoacrylate glue embolization is a minimally invasive treatment option for lymphatic leak after pelvic resection.

House of Generations

DEFF Research Database (Denmark)

Geert Jensen, Birgitte

2017-01-01

only the benefits of living close to the family. The Aarhus Municipality project "House of Generations" is a vision for creating a framework for relationships across all generations, for meaningful encounters and for rewarding neighbourliness. Three of Aarhus Municipality's magistrate departments...... participate in the project: Health and Care, Children and Youth, and Social Conditions and Employment. A public housing association that provides student dorms also participates in the project. The physical framework will be a building with a total area of approx. 25,000 m², located at Pier 4, at Aarhus......' harbour areas. The building will be a multi-generational house comprising a mixture of flexible public housing units for students, the elderly and residents who require care (elderly disabled people and people with acquired brain injuries). The building will be connected with common areas located in close...

ERP II: a conceptual framework for next-generation enterprise systems?

DEFF Research Database (Denmark)

Møller, Charles

2005-01-01

proposes a conceptual framework for extended enterprise resource planning (ERP II). The aim of this model is to compile present ES concepts into a comprehensive outline of ERP II, thus composing a generic map and taxonomy for corporate-wide enterprise systems. Research limitations/implications - The paper...

Risk perception and strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy

International Nuclear Information System (INIS)

Brewer, Jeffrey D.

2005-01-01

The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate the wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system

Popularity framework for monitoring user workload

International Nuclear Information System (INIS)

Molfetas, Angelos; Dimitrov, Gancho; Lassnig, Mario; Garonne, Vincent; Stewart, Graeme; Barisits, Martin; Beermann, Thomas

2012-01-01

This paper describes a monitoring framework for large scale data management systems with frequent data access. This framework allows large data management systems to generate meaningful information from collected tracing data and to be queried on demand for specific user usage patterns in respect to source and destination locations, period intervals, and other searchable parameters. The feasibility of such a system at the petabyte scale is demonstrated by describing the implementation and operational experience of a real world management information system for the ATLAS experiment employing the proposed framework. Our observations suggest that the proposed user monitoring framework is capable of scaling to meet the needs of very large data management systems.

Third generation coaching

DEFF Research Database (Denmark)

Stelter, Reinhard

2014-01-01

Third generation coaching unfolds a new universe for coaching and coaching psychology in the framework of current social research, new learning theories and discourses about personal leadership. Third generation coaching views coaching in a societal perspective. Coaching has become important...... transformation. Coaching thus facilitates new reflections and perspectives, as well as empowerment and support for self-Bildung processes. Third generation coaching focuses on the coach and the coachee in their narrative collaborative partnership. Unlike first generation coaching, where the goal is to help...

Model Based Analysis and Test Generation for Flight Software

Science.gov (United States)

Pasareanu, Corina S.; Schumann, Johann M.; Mehlitz, Peter C.; Lowry, Mike R.; Karsai, Gabor; Nine, Harmon; Neema, Sandeep

2009-01-01

We describe a framework for model-based analysis and test case generation in the context of a heterogeneous model-based development paradigm that uses and combines Math- Works and UML 2.0 models and the associated code generation tools. This paradigm poses novel challenges to analysis and test case generation that, to the best of our knowledge, have not been addressed before. The framework is based on a common intermediate representation for different modeling formalisms and leverages and extends model checking and symbolic execution tools for model analysis and test case generation, respectively. We discuss the application of our framework to software models for a NASA flight mission.

Embracing equifinality with efficiency: Limits of Acceptability sampling using the DREAM(LOA) algorithm

Science.gov (United States)

Vrugt, Jasper A.; Beven, Keith J.

2018-04-01

This essay illustrates some recent developments to the DiffeRential Evolution Adaptive Metropolis (DREAM) MATLAB toolbox of Vrugt (2016) to delineate and sample the behavioural solution space of set-theoretic likelihood functions used within the GLUE (Limits of Acceptability) framework (Beven and Binley, 1992, 2014; Beven and Freer, 2001; Beven, 2006). This work builds on the DREAM(ABC) algorithm of Sadegh and Vrugt (2014) and enhances significantly the accuracy and CPU-efficiency of Bayesian inference with GLUE. In particular it is shown how lack of adequate sampling in the model space might lead to unjustified model rejection.

A Framework for Effective Assessment of Model-based Projections of Biodiversity to Inform the Next Generation of Global Conservation Targets

Science.gov (United States)

Myers, B.; Beard, T. D.; Weiskopf, S. R.; Jackson, S. T.; Tittensor, D.; Harfoot, M.; Senay, G. B.; Casey, K.; Lenton, T. M.; Leidner, A. K.; Ruane, A. C.; Ferrier, S.; Serbin, S.; Matsuda, H.; Shiklomanov, A. N.; Rosa, I.

2017-12-01

Biodiversity and ecosystems services underpin political targets for the conservation of biodiversity; however, previous incarnations of these biodiversity-related targets have not relied on integrated model based projections of possible outcomes based on climate and land use change. Although a few global biodiversity models are available, most biodiversity models lie along a continuum of geography and components of biodiversity. Model-based projections of the future of global biodiversity are critical to support policymakers in the development of informed global conservation targets, but the scientific community lacks a clear strategy for integrating diverse data streams in developing, and evaluating the performance of, such biodiversity models. Therefore, in this paper, we propose a framework for ongoing testing and refinement of model-based projections of biodiversity trends and change, by linking a broad variety of biodiversity models with data streams generated by advances in remote sensing, coupled with new and emerging in-situ observation technologies to inform development of essential biodiversity variables, future global biodiversity targets, and indicators. Our two main objectives are to (1) develop a framework for model testing and refining projections of a broad range of biodiversity models, focusing on global models, through the integration of diverse data streams and (2) identify the realistic outputs that can be developed and determine coupled approaches using remote sensing and new and emerging in-situ observations (e.g., metagenomics) to better inform the next generation of global biodiversity targets.

Cross-Layer Framework for Fine-Grained Channel Access in Next Generation High-Density WiFi Networks

Institute of Scientific and Technical Information of China (English)

ZHAO Haitao; ZHANG Shaojie; Emiliano Garcia-Palacios

2016-01-01

Densely deployed WiFi networks will play a crucial role in providing the capacity for next generation mobile internet.However,due to increasing interference,overlapped channels in WiFi networks and throughput efficiency degradation,densely deployed WiFi networks is not a guarantee to obtain higher throughput.An emergent challenge is how to efficiently utilize scarce spectrum resources,by matching physical layer resources to traffic demand.In this aspect,access control allocation strategies play a pivotal role but remain too coarse-grained.As a solution,this research proposes a flexible framework for fine-grained channel width adaptation and multi-channel access in WiFi networks.This approach,named SFCA (Subcarrier Fine-grained Channel Access),adopts DOFDM (Discontinuous Orthogonal Frequency Division Multiplexing) at the PHY layer.It allocates the frequency resource with a subcarrier granularity,which facilitates the channel width adaptation for multi-channel access and thus brings more flexibility and higher frequency efficiency.The MAC layer uses a frequencytime domain backoff scheme,which combines the popular time-domain BEB scheme with a frequency-domain backoff to decrease access collision,resulting in higher access probability for the contending nodes.SFCA is compared with FICA (an established access scheme) showing significant outperformance.Finally we present results for next generation 802.11 ac WiFi networks.

Towards an analytical framework for tailoring supercontinuum generation.

Science.gov (United States)

Castelló-Lurbe, David; Vermeulen, Nathalie; Silvestre, Enrique

2016-11-14

A fully analytical toolbox for supercontinuum generation relying on scenarios without pulse splitting is presented. Furthermore, starting from the new insights provided by this formalism about the physical nature of direct and cascaded dispersive wave emission, a unified description of this radiation in both normal and anomalous dispersion regimes is derived. Previously unidentified physics of broadband spectra reported in earlier works is successfully explained on this basis. Finally, a foundry-compatible few-millimeters-long silicon waveguide allowing octave-spanning supercontinuum generation pumped at telecom wavelengths in the normal dispersion regime is designed, hence showcasing the potential of this new analytical approach.

Evaluating mobile learning practice. Towards a framework for analysis of user-generated contexts with reference to the socio-cultural ecology of mobile learning

Directory of Open Access Journals (Sweden)

Judith Seipold

2011-04-01

Full Text Available Against the conceptual and theoretical background of a socio-culturally orientated approach to mobile learning (Pachler, Bachmair and Cook, 2010, this paper examines the evaluation of user-generated contexts by referring to an example from the use of mobile phones in schools. We discuss how mobile device-related, user- generated contexts around structures, agency and cultural practices might be brought into a fruitful relationship with institution-based learning. And, we provide categories for evaluating the use of mobile devices to generate meaning from and with fragmented and discontinuous media and modes at the interface of learning in formal, institutionalised and informal, self-directed settings. The evaluation criteria build on the framework of a socio-cultural ecology of mobile learning developed by the London Mobile Learning Group.

A Framework for Creating Semantically Adaptive Collaborative E-learning Environments

Directory of Open Access Journals (Sweden)

Marija Cubric

2009-09-01

Full Text Available In this paper we present a framework that can be used to generate web-based, semantically adaptive, e-learning and computer-assisted assessment (CAA tools for any given knowledge domain, based upon dynamic ontological modeling. We accomplish this by generating “learning ontologies” for a given knowledge domain. The generated learning ontologies are built upon our previous work on a domain “Glossary” ontology and augmented with additional conceptual relations from the WordNet 3.0 lexical database, using Text2Onto, an open source ontology extraction tool. The main novelty of this work is in “on the fly” generation of computer assisted assessments based on the underlying ontology and pre-defined question templates that are founded on the Bloom’s taxonomy of educational objectives. The main deployment scenario for the framework is a web-service providing collaborative e- learning and knowledge management capabilities to various learning communities. The framework can be extended to provide collection and exploitation of the users’ learning behaviour metrics, in order to further adapt the generated e-learning environment to the learners’ needs.

Framework for generating expert systems to perform computer security risk analysis

International Nuclear Information System (INIS)

Smith, S.T.; Lim, J.J.

1985-01-01

At Los Alamos we are developing a framework to generate knowledge-based expert systems for performing automated risk analyses upon a subject system. The expert system is a computer program that models experts' knowledge about a topic, including facts, assumptions, insights, and decision rationale. The subject system, defined as the collection of information, procedures, devices, and real property upon which the risk analysis is to be performed, is a member of the class of systems that have three identifying characteristics: a set of desirable assets (or targets), a set of adversaries (or threats) desiring to obtain or to do harm to the assets, and a set of protective mechanisms to safeguard the assets from the adversaries. Risk analysis evaluates both vulnerability to and the impact of successful threats against the targets by determining the overall effectiveness of the subject system safeguards, identifying vulnerabilities in that set of safeguards, and determining cost-effective improvements to the safeguards. As a testbed, we evaluate the inherent vulnerabilities and risks in a system of computer security safeguards. The method considers safeguards protecting four generic targets (physical plant of the computer installation, its hardware, its software, and its documents and displays) against three generic threats (natural hazards, direct human actions requiring the presence of the adversary, and indirect human actions wherein the adversary is not on the premises-perhaps using such access tools as wiretaps, dialup lines, and so forth). Our automated procedure to assess the effectiveness of computer security safeguards differs from traditional risk analysis methods

Assessing sustainable remediation frameworks using sustainability principles.

Science.gov (United States)

Ridsdale, D Reanne; Noble, Bram F

2016-12-15

The remediation industry has grown exponentially in recent decades. International organizations of practitioners and remediation experts have developed several frameworks for integrating sustainability into remediation projects; however, there has been limited attention to how sustainability is approached and operationalized in sustainable remediation frameworks and practices - or whether sustainability plays any meaningful role at all in sustainable remediation. This paper examines how sustainability is represented in remediation frameworks and the guidance provided for practical application. Seven broad sustainability principles and review criteria are proposed and applied to a sample of six international remediation frameworks. Not all review criteria were equally satisfied and none of the frameworks fully met all criteria; however, the best performing frameworks were those identified as sustainability remediation frameworks. Intra-generational equity was addressed by all frameworks. Integrating social, economic and biophysical components beyond triple-bottom-line indicators was explicitly addressed only by the sustainable remediation frameworks. No frameworks provided principle- or rule-based guidance for dealing with trade-offs in sustainability decisions. Copyright © 2016 Elsevier Ltd. All rights reserved.

An extended framework for science.

Science.gov (United States)

Cazalis, Roland

2017-12-01

We may be at the cusp of a next generation framework for science which can be facilitated by understanding current limitations in the context of a divergence of 'scientific' tradition from the Axial Age (800-200 BCE) to the present. A powerful advance may come from fusing certain elements from Western and Eastern traditions, synthesizing the framework with an apt understanding of the divergence. Key traits will include the ethopoetic nature of the scientist with attention to his/her experience of self. The framework will also 'access' knowledge through a state of mind less encumbered with paradoxes, duality, incompatibility and other aporias. Case studies in biology and physics illustrate possibilities. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Generational Approach to Understanding Students

Science.gov (United States)

Coomes, Michael D.; DeBard, Robert

2004-01-01

This chapter establishes the conceptual framework for understanding the Millennial generation by presenting a theoretical model of generational succession that demonstrates the value of studying how the values of one generation interact with and are influenced by others.

An XML-based framework for personalized health management.

Science.gov (United States)

Lee, Hiye-Ja; Park, Seung-Hun; Jeong, Byeong-Soo

2006-01-01

This paper proposes a framework for personalized health management. In this framework, XML technology is used for representing and managing the health information and knowledge. Major components of the framework are Health Management Prescription (HMP) Expert System and Health Information Repository. The HMP Expert System generates a HMP efficiently by using XML-based templates. Health Information Repository provides integrated health information and knowledge for personalized health management by using XML and relational database together.

Design and Analysis of Web Application Frameworks

DEFF Research Database (Denmark)

Schwarz, Mathias Romme

-state manipulation vulnerabilities. The hypothesis of this dissertation is that we can design frameworks and static analyses that aid the programmer to avoid such errors. First, we present the JWIG web application framework for writing secure and maintainable web applications. We discuss how this framework solves...... some of the common errors through an API that is designed to be safe by default. Second, we present a novel technique for checking HTML validity for output that is generated by web applications. Through string analysis, we approximate the output of web applications as context-free grammars. We model......Numerous web application frameworks have been developed in recent years. These frameworks enable programmers to reuse common components and to avoid typical pitfalls in web application development. Although such frameworks help the programmer to avoid many common errors, we nd...

Theoretical limit on iota→rhoγ and constraints on glueball--qq-bar-meson couplings with the pion and the isovector photon

International Nuclear Information System (INIS)

Slaughter, M.D.; Oneda, S.

1987-01-01

Within the formalism and theoretical framework of asymptotic SU/sub F/(4) symmetry plus the constraint algebras involving the generators of the underlying symmetries of QCD, we derive an important relation between meson isoscalar-isovector matrix elements of the electromagnetic current and corresponding matrix elements of the axial-vector charge A/sub π/. A lower bound is calculated for the rate Γ(iota→rhoγ) which indicates that Γ(iota→rhoγ) is of the order of 1 MeV, with its exact value depending upon the rates Γ(iota→δπ) and Γ(δ→etaπ). The estimate of the lower bound is independent of the specific quark and glue content of the iota

A Unified Framework for Creating Domain Dependent Polarity Lexicons from User Generated Reviews.

Directory of Open Access Journals (Sweden)

Muhammad Zubair Asghar

Full Text Available The exponential increase in the explosion of Web-based user generated reviews has resulted in the emergence of Opinion Mining (OM applications for analyzing the users' opinions toward products, services, and policies. The polarity lexicons often play a pivotal role in the OM, indicating the positivity and negativity of a term along with the numeric score. However, the commonly available domain independent lexicons are not an optimal choice for all of the domains within the OM applications. The aforementioned is due to the fact that the polarity of a term changes from one domain to other and such lexicons do not contain the correct polarity of a term for every domain. In this work, we focus on the problem of adapting a domain dependent polarity lexicon from set of labeled user reviews and domain independent lexicon to propose a unified learning framework based on the information theory concepts that can assign the terms with correct polarity (+ive, -ive scores. The benchmarking on three datasets (car, hotel, and drug reviews shows that our approach improves the performance of the polarity classification by achieving higher accuracy. Moreover, using the derived domain dependent lexicon changed the polarity of terms, and the experimental results show that our approach is more effective than the base line methods.

Identifying problems and generating recommendations for enhancing complex systems: applying the abstraction hierarchy framework as an analytical tool.

Science.gov (United States)

Xu, Wei

2007-12-01

This study adopts J. Rasmussen's (1985) abstraction hierarchy (AH) framework as an analytical tool to identify problems and pinpoint opportunities to enhance complex systems. The process of identifying problems and generating recommendations for complex systems using conventional methods is usually conducted based on incompletely defined work requirements. As the complexity of systems rises, the sheer mass of data generated from these methods becomes unwieldy to manage in a coherent, systematic form for analysis. There is little known work on adopting a broader perspective to fill these gaps. AH was used to analyze an aircraft-automation system in order to further identify breakdowns in pilot-automation interactions. Four steps follow: developing an AH model for the system, mapping the data generated by various methods onto the AH, identifying problems based on the mapped data, and presenting recommendations. The breakdowns lay primarily with automation operations that were more goal directed. Identified root causes include incomplete knowledge content and ineffective knowledge structure in pilots' mental models, lack of effective higher-order functional domain information displayed in the interface, and lack of sufficient automation procedures for pilots to effectively cope with unfamiliar situations. The AH is a valuable analytical tool to systematically identify problems and suggest opportunities for enhancing complex systems. It helps further examine the automation awareness problems and identify improvement areas from a work domain perspective. Applications include the identification of problems and generation of recommendations for complex systems as well as specific recommendations regarding pilot training, flight deck interfaces, and automation procedures.

Experimental study on the viscosity and adhesive performance of exogenous liquid fibrin glue.

Science.gov (United States)

Hayashi, Takuro; Hasegawa, Mitsuhiro; Inamasu, Joji; Adachi, Kazuhide; Nagahisa, Shinya; Hirose, Yuichi

2014-01-01

Exogenous fibrin glue (FG) is highly suitable for neurosurgical procedures, because of its viscosity and adhesive properties. Several FGs are commercially available, but only few reports detail their differences. In the present study, we investigated the viscosity and adhesive performance of two types of FG: one is derived from blood donated in Europe and the United States (CSL Behring's Beriplast(®), BP) and the other is derived from blood donated in Japan (the Chemo-Sero-Therapeutic Research Institute's Bolheal(®), BH). The viscosity test that measured fibrinogen viscosity revealed that BP had significantly higher viscosity than BH. Similarly, the dripping test showed that BP traveled a significantly shorter drip distance in the vertical direction than BH, although the transverse diameter of the coagulated FG did not differ statistically significantly. In the tensile strength test, BP showed superior adhesion performance over BH. The histological study of the hematoxylin-eosin-stained specimens in both groups showed favorable adhesion. Although further studies are required on its manufacturing and usage methods, FG shows differences in viscosity and adhesive performance according to the blood from which it is derived. We conclude that it is desirable to select the type and usage method of FG according to the characteristics of the surgical operation in question. Our findings suggest that FG produced from the blood donated in Europe and the United States might be more suitable for use in surgical procedures that demand an especially high degree of viscosity and rapid adhesive performance.

Original Framework for Optimizing Hybrid Energy Supply

Directory of Open Access Journals (Sweden)

Amevi Acakpovi

2016-01-01

Full Text Available This paper proposes an original framework for optimizing hybrid energy systems. The recent growth of hybrid energy systems in remote areas across the world added to the increasing cost of renewable energy has triggered the inevitable development of hybrid energy systems. Hybrid energy systems always pose a problem of optimization of cost which has been approached with different perspectives in the recent past. This paper proposes a framework to guide the techniques of optimizing hybrid energy systems in general. The proposed framework comprises four stages including identification of input variables for energy generation, establishment of models of energy generation by individual sources, development of artificial intelligence, and finally summation of selected sources. A case study of a solar, wind, and hydro hybrid system was undertaken with a linear programming approach. Substantial results were obtained with regard to how load requests were constantly satisfied while minimizing the cost of electricity. The developed framework gained its originality from the fact that it has included models of individual sources of energy that even make the optimization problem more complex. This paper also has impacts on the development of policies which will encourage the integration and development of renewable energies.

Utilização de adesivo de fibrina em cirurgias oftalmológicas Use of fibrin glue in ocular surgery

Directory of Open Access Journals (Sweden)

Melissa Manfroi Dal Pizzol

2009-06-01

Full Text Available OBJETIVO: Avaliar as diferentes técnicas cirúrgicas oftalmológicas nas quais se pode utilizar a cola biológica e possíveis complicações relacionadas ao seu uso. MÉTODOS: Estudo de série de casos retrospectivo, não-comparativo. Foram avaliados 161 olhos de pacientes com idade média de 51,8 anos em que foi utilizada cola biológica (Beriplast P® - Aventis Behring, Alemanha para fixação de tecido ou fechamento incisional. RESULTADOS: Foram avaliados 76 pacientes com pterígio, 4 com ceratoconjuntivite límbica superior, 4 com tumor limbar, 21 com conjuntivocálase, 31 com ceratopatia bolhosa, 7 com deficiência límbica, 6 com queimadura alcalina, 2 com Stevens-Johnson, 5 com catarata e 5 com glaucoma. Complicações foram relatas em 28 casos (17,4%. Descolamento do tecido fixado e granuloma foram as complicações mais frequentes. Descolamento ocorreu em 10 casos (5,6% (7 em transplante de membrana amniótica em ceratopatia bolhosa, 2 em transplante de conjuntiva autólogo após exérese de pterígio, 1 após transplante de limbo autólogo por Stevens-Johnson. Granuloma ocorreu em 9 casos (5,6% (5 em pacientes com queimadura alcalina aguda tratados com transplante de membrana amniótica, 1 em paciente com sequela de queimadura tratado com transplante de limbo autólogo e 3 em pacientes após exérese de pterígio tratados com transplante de conjuntiva autólogo. Todas as complicações ocorreram dentro da primeira semana de pós-operatório. CONCLUSÃO: Embora o presente seja retrospectivo e não-comparativo, podemos observar que a utilização do adesivo de fibrina parece ser segura e efetiva, além de apresentar baixas taxas de complicações nas cirurgias de superfície ocular e de segmento anterior.PURPOSE: To evaluate the use of fibrin glue and its complications in different ophthalmic surgeries. METHODS: A retrospective and non-comparative case series study. 161 eyes were evaluated. The mean age was 51.8 years. Fibrin glue

Developing a User-Driven Framework for Generating Field Data Collection Applications

Energy Technology Data Exchange (ETDEWEB)

Lee, Timothy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2014-09-09

This paper describes the implementation of a web-based framework, which allows end users to build custom data collection applications. The emphasis of this project is to ease the transition from handwritten forms to electronic mobile applications for data collection.

A Reasoning And Hypothesis-Generation Framework Based On Scalable Graph Analytics

Energy Technology Data Exchange (ETDEWEB)

Sukumar, Sreenivas Rangan [ORNL

2016-01-01

Finding actionable insights from data has always been difficult. As the scale and forms of data increase tremendously, the task of finding value becomes even more challenging. Data scientists at Oak Ridge National Laboratory are leveraging unique leadership infrastructure (e.g. Urika-XA and Urika-GD appliances) to develop scalable algorithms for semantic, logical and statistical reasoning with unstructured Big Data. We present the deployment of such a framework called ORiGAMI (Oak Ridge Graph Analytics for Medical Innovations) on the National Library of Medicine s SEMANTIC Medline (archive of medical knowledge since 1994). Medline contains over 70 million knowledge nuggets published in 23.5 million papers in medical literature with thousands more added daily. ORiGAMI is available as an open-science medical hypothesis generation tool - both as a web-service and an application programming interface (API) at http://hypothesis.ornl.gov . Since becoming an online service, ORIGAMI has enabled clinical subject-matter experts to: (i) discover the relationship between beta-blocker treatment and diabetic retinopathy; (ii) hypothesize that xylene is an environmental cancer-causing carcinogen and (iii) aid doctors with diagnosis of challenging cases when rare diseases manifest with common symptoms. In 2015, ORiGAMI was featured in the Historical Clinical Pathological Conference in Baltimore as a demonstration of artificial intelligence to medicine, IEEE/ACM Supercomputing and recognized as a Centennial Showcase Exhibit at the Radiological Society of North America (RSNA) Conference in Chicago. The final paper will describe the workflow built for the Cray Urika-XA and Urika-GD appliances that is able to reason with the knowledge of every published medical paper every time a clinical researcher uses the tool.

GeoFramework: A Modeling Framework for Solid Earth Geophysics

Science.gov (United States)

Gurnis, M.; Aivazis, M.; Tromp, J.; Tan, E.; Thoutireddy, P.; Liu, Q.; Choi, E.; Dicaprio, C.; Chen, M.; Simons, M.; Quenette, S.; Appelbe, B.; Aagaard, B.; Williams, C.; Lavier, L.; Moresi, L.; Law, H.

2003-12-01

As data sets in geophysics become larger and of greater relevance to other earth science disciplines, and as earth science becomes more interdisciplinary in general, modeling tools are being driven in new directions. There is now a greater need to link modeling codes to one another, link modeling codes to multiple datasets, and to make modeling software available to non modeling specialists. Coupled with rapid progress in computer hardware (including the computational speed afforded by massively parallel computers), progress in numerical algorithms, and the introduction of software frameworks, these lofty goals of merging software in geophysics are now possible. The GeoFramework project, a collaboration between computer scientists and geoscientists, is a response to these needs and opportunities. GeoFramework is based on and extends Pyre, a Python-based modeling framework, recently developed to link solid (Lagrangian) and fluid (Eulerian) models, as well as mesh generators, visualization packages, and databases, with one another for engineering applications. The utility and generality of Pyre as a general purpose framework in science is now being recognized. Besides its use in engineering and geophysics, it is also being used in particle physics and astronomy. Geology and geophysics impose their own unique requirements on software frameworks which are not generally available in existing frameworks and so there is a need for research in this area. One of the special requirements is the way Lagrangian and Eulerian codes will need to be linked in time and space within a plate tectonics context. GeoFramework has grown beyond its initial goal of linking a limited number of exiting codes together. The following codes are now being reengineered within the context of Pyre: Tecton, 3-D FE Visco-elastic code for lithospheric relaxation; CitComS, a code for spherical mantle convection; SpecFEM3D, a SEM code for global and regional seismic waves; eqsim, a FE code for dynamic

Framework for Proliferation Resistance and Physical Protection for Nonproliferation Impact Assessments

International Nuclear Information System (INIS)

Bari, R.

2008-01-01

This report describes a framework for proliferation resistance and physical protection evaluation for the fuel cycle systems envisioned in the expansion of nuclear power for electricity generation. The methodology is based on an approach developed as part of the Generation IV technical evaluation framework and on a qualitative evaluation approach to policy factors similar to those that were introduced in previous Nonproliferation Impact Assessments performed by DOE

Phosphate Framework Electrode Materials for Sodium Ion Batteries.

Science.gov (United States)

Fang, Yongjin; Zhang, Jiexin; Xiao, Lifen; Ai, Xinping; Cao, Yuliang; Yang, Hanxi

2017-05-01

Sodium ion batteries (SIBs) have been considered as a promising alternative for the next generation of electric storage systems due to their similar electrochemistry to Li-ion batteries and the low cost of sodium resources. Exploring appropriate electrode materials with decent electrochemical performance is the key issue for development of sodium ion batteries. Due to the high structural stability, facile reaction mechanism and rich structural diversity, phosphate framework materials have attracted increasing attention as promising electrode materials for sodium ion batteries. Herein, we review the latest advances and progresses in the exploration of phosphate framework materials especially related to single-phosphates, pyrophosphates and mixed-phosphates. We provide the detailed and comprehensive understanding of structure-composition-performance relationship of materials and try to show the advantages and disadvantages of the materials for use in SIBs. In addition, some new perspectives about phosphate framework materials for SIBs are also discussed. Phosphate framework materials will be a competitive and attractive choice for use as electrodes in the next-generation of energy storage devices.

A Framework for the Generation and Dissemination of Drop Size Distribution (DSD) Characteristics Using Multiple Platforms

Science.gov (United States)

Wolf, David B.; Tokay, Ali; Petersen, Walt; Williams, Christopher; Gatlin, Patrick; Wingo, Mathew

2010-01-01

Proper characterization of the precipitation drop size distribution (DSD) is integral to providing realistic and accurate space- and ground-based precipitation retrievals. Current technology allows for the development of DSD products from a variety of platforms, including disdrometers, vertical profilers and dual-polarization radars. Up to now, however, the dissemination or availability of such products has been limited to individual sites and/or field campaigns, in a variety of formats, often using inconsistent algorithms for computing the integral DSD parameters, such as the median- and mass-weighted drop diameter, total number concentration, liquid water content, rain rate, etc. We propose to develop a framework for the generation and dissemination of DSD characteristic products using a unified structure, capable of handling the myriad collection of disdrometers, profilers, and dual-polarization radar data currently available and to be collected during several upcoming GPM Ground Validation field campaigns. This DSD super-structure paradigm is an adaptation of the radar super-structure developed for NASA s Radar Software Library (RSL) and RSL_in_IDL. The goal is to provide the DSD products in a well-documented format, most likely NetCDF, along with tools to ingest and analyze the products. In so doing, we can develop a robust archive of DSD products from multiple sites and platforms, which should greatly benefit the development and validation of precipitation retrieval algorithms for GPM and other precipitation missions. An outline of this proposed framework will be provided as well as a discussion of the algorithms used to calculate the DSD parameters.

Steam generator tube integrity requirements and operating experience in the United States

International Nuclear Information System (INIS)

Karwoski, K.J.

2009-01-01

Steam generator tube integrity is important to the safe operation of pressurized-water reactors. For ensuring tube integrity, the U.S. Nuclear Regulatory Commission uses a regulatory framework that is largely performance based. This performance-based framework is supplemented with some prescriptive requirements. The framework recognizes that there are three combinations of tube materials and heat treatments currently used in the United States and that the operating experience depends, in part, on the type of material used. This paper summarizes the regulatory framework for ensuring steam generator tube integrity, it highlights the current status of steam generators, and it highlights some of the steam generator issues and challenges that exist in the United States. (author)

A qualitative evaluation approach for energy system modelling frameworks

DEFF Research Database (Denmark)

Wiese, Frauke; Hilpert, Simon; Kaldemeyer, Cord

2018-01-01

properties define how useful it is in regard to the existing challenges. For energy system models, evaluation methods exist, but we argue that many decisions upon properties are rather made on the model generator or framework level. Thus, this paper presents a qualitative approach to evaluate frameworks...

Frameworks for management, storage and preparation of large data volumes Big Data

Directory of Open Access Journals (Sweden)

Marco Antonio Almeida Pamiño

2017-05-01

Full Text Available Weather systems like the World Meteorological Organization ́s Global Information System need to store different kinds of images, data and files. Big Data and its 3V paradigm can provide a suitable solution to solve this problem. This tutorial presents some concepts around the Hadoop framework, de facto standard implementation of Big Data, and how to store semi-estructured data generated by automatic weather stations using this framework. Finally, a formal method to generate weather reports using Hadoop ́s ecosystem frameworks is presented.

Next Generation Simulation Framework for Robotic and Human Space Missions

Science.gov (United States)

Cameron, Jonathan M.; Balaram, J.; Jain, Abhinandan; Kuo, Calvin; Lim, Christopher; Myint, Steven

2012-01-01

The Dartslab team at NASA's Jet Propulsion Laboratory (JPL) has a long history of developing physics-based simulations based on the Darts/Dshell simulation framework that have been used to simulate many planetary robotic missions, such as the Cassini spacecraft and the rovers that are currently driving on Mars. Recent collaboration efforts between the Dartslab team at JPL and the Mission Operations Directorate (MOD) at NASA Johnson Space Center (JSC) have led to significant enhancements to the Dartslab DSENDS (Dynamics Simulator for Entry, Descent and Surface landing) software framework. The new version of DSENDS is now being used for new planetary mission simulations at JPL. JSC is using DSENDS as the foundation for a suite of software known as COMPASS (Core Operations, Mission Planning, and Analysis Spacecraft Simulation) that is the basis for their new human space mission simulations and analysis. In this paper, we will describe the collaborative process with the JPL Dartslab and the JSC MOD team that resulted in the redesign and enhancement of the DSENDS software. We will outline the improvements in DSENDS that simplify creation of new high-fidelity robotic/spacecraft simulations. We will illustrate how DSENDS simulations are assembled and show results from several mission simulations.

NEAMS-IPL MOOSE Midyear Framework Activities

International Nuclear Information System (INIS)

Permann, Cody; Alger, Brian; Peterson, John; Slaughter, Andrew; Andrš, David; Martineau, Richard

2017-01-01

The MOOSE Framework is a modular pluggable framework for building complex simulations. The ability to add new objects with custom syntax is a core capability that makes MOOSE a powerful platform for coupling multiple applications together within a single environment. The creation of a new, more standardized JSON syntax output improves the external interfaces for generating graphical components or for validating input file syntax. The design of this interface and the requirements it satisfies are covered in this short report.

NEAMS-IPL MOOSE Midyear Framework Activities

Energy Technology Data Exchange (ETDEWEB)

Permann, Cody [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alger, Brian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Peterson, John [Idaho National Lab. (INL), Idaho Falls, ID (United States); Slaughter, Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States); Andrš, David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Martineau, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2017-05-09

The MOOSE Framework is a modular pluggable framework for building complex simulations. The ability to add new objects with custom syntax is a core capability that makes MOOSE a powerful platform for coupling multiple applications together within a single environment. The creation of a new, more standardized JSON syntax output improves the external interfaces for generating graphical components or for validating input file syntax. The design of this interface and the requirements it satisfies are covered in this short report.

Hydrazine-hydrothermal method to synthesize three-dimensional chalcogenide framework for photocatalytic hydrogen generation

International Nuclear Information System (INIS)

Liu Yi; Kanhere, Pushkar D.; Wong, Chui Ling; Tian Yuefeng; Feng Yuhua; Boey, Freddy; Wu, Tom; Chen Hongyu; White, Tim J.; Chen Zhong; Zhang Qichun

2010-01-01

A novel chalcogenide, [Mn 2 Sb 2 S 5 (N 2 H 4 ) 3 ] (1), has been synthesized by the hydrazine-hydrothermal method. X-ray crystallography study reveals that the new compound 1 crystallizes in space group P1-bar (no. 2) of the triclinic system. The structure features an open neutral three-dimensional framework, where two-dimensional mesh-like inorganic layers are bridged by intra- and inter-layer hydrazine ligands. Both two Mn1 and Mn2 sites adopt distorted octahedral coordination. While two Sb1 and Sb2 sites exhibit two different coordination geometries, the Sb1 site is coordinated with three S atoms to generate a SbS 3 trigonal-pyramidal geometry, and the Sb2 site adopts a SbS 4 trigonal bipyramidal coordination geometry. It has an optical band gap of about ∼2.09 eV, which was deduced from the diffuse reflectance spectrum, and displays photocatalytic behaviors under visible light irradiation. Magnetic susceptibility measurements show compound 1 obeys the Curie-Weiss law in the range of 50-300 K. -- Graphical abstract: A novel chalcogenide, [Mn 2 Sb 2 S 5 (N 2 H 4 ) 3 ] (1), synthesized by hydrazine-hydrothermal method, has a band gap of about ∼2.09 eV and displays photocatalytic behaviors under visible light irradiation. Display Omitted

Deep Convolutional Generative Adversarial Network for Procedural 3D Landscape Generation Based on DEM

OpenAIRE

Wulff-Jensen, Andreas; Rant, Niclas Nerup; Møller, Tobias Nordvig; Billeskov, Jonas Aksel

2018-01-01

This paper proposes a novel framework for improving procedural generation of 3D landscapes using machine learning. We utilized a Deep Convolutional Generative Adversarial Network (DC-GAN) to generate heightmaps. The network was trained on a dataset consisting of Digital Elevation Maps (DEM) of the alps. During map generation, the batch size and learning rate were optimized for the most efficient and satisfying map production. The diversity of the final output was tested against Perlin noise u...

Developing a DSR-HNS policy making framework for electric energy systems

International Nuclear Information System (INIS)

Meyar-Naimi, H.; Vaez-Zadeh, S.

2012-01-01

Sustainable Development (SD) has played a major role as a foundation of several policy making frameworks developed mainly by international organizations. In this paper, some critical points regarding the origination and formulation of the SD concept are discussed. It is argued that the SD concerns with selected sectors and regions rather than the whole society and all regions of the world. To tackle these shortcomings, the conventional definition of SD is extended in this paper according to a broad philosophy of harmonizing key aspects of human, nature and systems performances over generations. Based on this extended definition, an improved Driving Force–State–Response (DSR-HNS) policy making framework is introduced. The main contribution is the modeling of the state block by human, nature and systems components to design overall and coherent policies. A procedure using the framework is also elaborated to monitor the current policies and design new ones, which provides a dynamic, nonlinear, feedback controlled policy making practice, not accommodated by existing policy making frameworks. Finally, a case study is presented to evaluate the effectiveness of the modified framework and the proposed model. The study assesses Iran's electric power generation system from sustainability point of view and develops new policies. - Highlights: ► Some critical points regarding the Sustainable Development (SD) concept are discussed. ► Based on this extended definition, a policy making framework is introduced. ► A policy making procedure based on the framework is elaborated. ► A case study is presented to evaluate the effectiveness of the modified framework. ► New policies are developed for Iran's power generation system.

An eFTD-VP framework for efficiently generating patient-specific anatomically detailed facial soft tissue FE mesh for craniomaxillofacial surgery simulation.

Science.gov (United States)

Zhang, Xiaoyan; Kim, Daeseung; Shen, Shunyao; Yuan, Peng; Liu, Siting; Tang, Zhen; Zhang, Guangming; Zhou, Xiaobo; Gateno, Jaime; Liebschner, Michael A K; Xia, James J

2018-04-01

Accurate surgical planning and prediction of craniomaxillofacial surgery outcome requires simulation of soft tissue changes following osteotomy. This can only be achieved by using an anatomically detailed facial soft tissue model. The current state-of-the-art of model generation is not appropriate to clinical applications due to the time-intensive nature of manual segmentation and volumetric mesh generation. The conventional patient-specific finite element (FE) mesh generation methods are to deform a template FE mesh to match the shape of a patient based on registration. However, these methods commonly produce element distortion. Additionally, the mesh density for patients depends on that of the template model. It could not be adjusted to conduct mesh density sensitivity analysis. In this study, we propose a new framework of patient-specific facial soft tissue FE mesh generation. The goal of the developed method is to efficiently generate a high-quality patient-specific hexahedral FE mesh with adjustable mesh density while preserving the accuracy in anatomical structure correspondence. Our FE mesh is generated by eFace template deformation followed by volumetric parametrization. First, the patient-specific anatomically detailed facial soft tissue model (including skin, mucosa, and muscles) is generated by deforming an eFace template model. The adaptation of the eFace template model is achieved by using a hybrid landmark-based morphing and dense surface fitting approach followed by a thin-plate spline interpolation. Then, high-quality hexahedral mesh is constructed by using volumetric parameterization. The user can control the resolution of hexahedron mesh to best reflect clinicians' need. Our approach was validated using 30 patient models and 4 visible human datasets. The generated patient-specific FE mesh showed high surface matching accuracy, element quality, and internal structure matching accuracy. They can be directly and effectively used for clinical

A generative inference framework for analysing patterns of cultural change in sparse population data with evidence for fashion trends in LBK culture.

Science.gov (United States)

Kandler, Anne; Shennan, Stephen

2015-12-06

Cultural change can be quantified by temporal changes in frequency of different cultural artefacts and it is a central question to identify what underlying cultural transmission processes could have caused the observed frequency changes. Observed changes, however, often describe the dynamics in samples of the population of artefacts, whereas transmission processes act on the whole population. Here we develop a modelling framework aimed at addressing this inference problem. To do so, we firstly generate population structures from which the observed sample could have been drawn randomly and then determine theoretical samples at a later time t2 produced under the assumption that changes in frequencies are caused by a specific transmission process. Thereby we also account for the potential effect of time-averaging processes in the generation of the observed sample. Subsequent statistical comparisons (e.g. using Bayesian inference) of the theoretical and observed samples at t2 can establish which processes could have produced the observed frequency data. In this way, we infer underlying transmission processes directly from available data without any equilibrium assumption. We apply this framework to a dataset describing pottery from settlements of some of the first farmers in Europe (the LBK culture) and conclude that the observed frequency dynamic of different types of decorated pottery is consistent with age-dependent selection, a preference for 'young' pottery types which is potentially indicative of fashion trends. © 2015 The Author(s).

Developing a Theoretical Framework Using a Nursing Perspective to Investigate Perceived Health in the "Sandwich Generation" Group.

Science.gov (United States)

Oulevey Bachmann, Annie; Danuser, Brigitta; Morin, Diane

2015-10-01

Coexisting workloads from professional, household and family, and caregiving activities for frail parents expose middle-aged individuals, the so-called "Sandwich Generation", to potential health risks. Current trends suggest that this situation will continue or increase. Thus SG health promotion has become a nursing concern. Most existing research considers coexisting workloads a priori pathogenic. Most studies have examined the association of one, versus two, of these three activities with health. Few studies have used a nursing perspective. This article presents the development of a framework based on a nursing model. We integrated Siegrist's Effort-Reward Imbalance middle-range theory into "Neuman Systems Model". The latter was chosen for its salutogenic orientation, its attention to preventive nursing interventions and the opportunity it provides to simultaneously consider positive and negative perceptions of SG health and SG coexisting workloads. Finally, it facilitated a theoretical identification of health protective factors. © The Author(s) 2015.

Framework for control system development

International Nuclear Information System (INIS)

Cork, C.; Nishimura, Hiroshi

1992-01-01

Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

Framework for control system development

International Nuclear Information System (INIS)

Cork, C.; Nishimura, Hiroshi.

1991-11-01

Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

Security Frameworks for Machine-to-Machine Devices and Networks

Science.gov (United States)

Demblewski, Michael

Attacks against mobile systems have escalated over the past decade. There have been increases of fraud, platform attacks, and malware. The Internet of Things (IoT) offers a new attack vector for Cybercriminals. M2M contributes to the growing number of devices that use wireless systems for Internet connection. As new applications and platforms are created, old vulnerabilities are transferred to next-generation systems. There is a research gap that exists between the current approaches for security framework development and the understanding of how these new technologies are different and how they are similar. This gap exists because system designers, security architects, and users are not fully aware of security risks and how next-generation devices can jeopardize safety and personal privacy. Current techniques, for developing security requirements, do not adequately consider the use of new technologies, and this weakens countermeasure implementations. These techniques rely on security frameworks for requirements development. These frameworks lack a method for identifying next generation security concerns and processes for comparing, contrasting and evaluating non-human device security protections. This research presents a solution for this problem by offering a novel security framework that is focused on the study of the "functions and capabilities" of M2M devices and improves the systems development life cycle for the overall IoT ecosystem.

EFFECTS OF PRESS PRESSURE ON GLUE LINE THICKNESS AND PROPERTIES OF LAMINATED VENEER LUMBER GLUED WITH MELAMINE UREA FORMALDEHYDE ADHESIVE

Directory of Open Access Journals (Sweden)

Ramazan Kurt,

2012-07-01

Full Text Available Laminated veneer lumbers (LVLs were manufactured from half-round sliced I-214 hybrid poplar clone veneers with MUF adhesives using press pressures ranging from 2.5 to 15 kg cm-2. The results showed that the press pressures affected the glue line thickness (GLT and the physical and mechanical properties of the LVLs. Higher specific gravity (SG and mechanical properties, but lower GLT were developed as a result of using higher press pressures. The optimum press pressure was found to be 10 kg cm-2 in relation to GLT, SG, and mechanical properties. Significant linear correlations were found between GLT and mechanical properties. GLT can be used to determine the quality of wood bonding and may become a valuable tool for this purpose. Reliable data on the optimum GLT and press pressures can be used to design safe wood bonding applications in all aspects of wood based composites, as well as wood constructions when appropriate techniques are adopted to measure the GLT.

Improving ecosystem service frameworks to address wicked problems

Directory of Open Access Journals (Sweden)

Kathryn K. Davies

2015-06-01

Full Text Available Complex problems often result from the multiple interactions between human activities and ecosystems. The interconnected nature of ecological and social systems should be considered if these "wicked problems" are to be addressed. Ecosystem service approaches provide an opportunity to link ecosystem function with social values, but in practice the essential role that social dynamics play in the delivery of outcomes remains largely unexplored. Social factors such as management regimes, power relationships, skills, and values, can dramatically affect the definition and delivery of ecosystem services. Input from a diverse group of stakeholders improves the capacity of ecosystem service approaches to address wicked problems by acknowledging diverse sets of values and accounting for conflicting world views. Participatory modeling can incorporate both social and ecological dynamics into decision making that involves stakeholders, but is itself a complex social undertaking that may not yield precise or predictable outcomes. We explore the efficacy of different types of participatory modeling in relation to the integration of social values into ecosystem services frameworks and the generation of four important elements of social capital needed to address wicked problems: enhancing social learning and capacity building; increasing transparency; mediating power; and building trust. Our findings indicate that mediated modeling, group mapping, and mental/conceptual modeling are likely to generate elements of social capital that can improve ecosystem service frameworks. Participatory simulation, system dynamic modeling, and Bayesian belief networks, if utilized in isolation, were found to have a low likelihood of generating the social capital needed to improve ecosystem services frameworks. Scenario planning, companion modeling, group model building, and participatory mapping all generate a moderate to high level of social capital elements that improve the

A multistage framework for reliability-based distribution expansion planning considering distributed generations by a self-adaptive global-based harmony search algorithm

International Nuclear Information System (INIS)

Shivaie, Mojtaba; Ameli, Mohammad T.; Sepasian, Mohammad S.; Weinsier, Philip D.; Vahidinasab, Vahid

2015-01-01

In this paper, the authors present a new multistage framework for reliability-based Distribution Expansion Planning (DEP) in which expansion options are a reinforcement and/or installation of substations, feeders, and Distributed Generations (DGs). The proposed framework takes into account not only costs associated with investment, maintenance, and operation, but also expected customer interruption cost in the optimization as four problem objectives. At the same time, operational restrictions, Kirchhoff's laws, radial structure limitation, voltage limits, and capital expenditure budget restriction are considered as problem constraints. The proposed model is a non-convex optimization problem having a non-linear, mixed-integer nature. Hence, a hybrid Self-adaptive Global-based Harmony Search Algorithm (SGHSA) and Optimal Power Flow (OPF) were used and followed by a fuzzy satisfying method in order to obtain the final optimal solution. The SGHSA is a recently developed optimization algorithm which imitates the music improvisation process. In this process, the harmonists improvise their instrument pitches, searching for the perfect state of harmony. The planning methodology was demonstrated on the 27-node, 13.8-kV test system in order to demonstrate the feasibility and capability of the proposed model. Simulation results illustrated the sufficiency and profitableness of the newly developed framework, when compared with other methods. - Highlights: • A new multistage framework is presented for reliability-based DEP problem. • In this paper, DGs are considered as an expansion option to increase the flexibility of the proposed model. • In this paper, effective factors of DEP problem are incorporated as a multi-objective model. • In this paper, three new algorithms HSA, IHSA and SGHSA are proposed. • Results obtained by the proposed SGHSA algorithm are better than others

AdaFF: Adaptive Failure-Handling Framework for Composite Web Services

Science.gov (United States)

Kim, Yuna; Lee, Wan Yeon; Kim, Kyong Hoon; Kim, Jong

In this paper, we propose a novel Web service composition framework which dynamically accommodates various failure recovery requirements. In the proposed framework called Adaptive Failure-handling Framework (AdaFF), failure-handling submodules are prepared during the design of a composite service, and some of them are systematically selected and automatically combined with the composite Web service at service instantiation in accordance with the requirement of individual users. In contrast, existing frameworks cannot adapt the failure-handling behaviors to user's requirements. AdaFF rapidly delivers a composite service supporting the requirement-matched failure handling without manual development, and contributes to a flexible composite Web service design in that service architects never care about failure handling or variable requirements of users. For proof of concept, we implement a prototype system of the AdaFF, which automatically generates a composite service instance with Web Services Business Process Execution Language (WS-BPEL) according to the users' requirement specified in XML format and executes the generated instance on the ActiveBPEL engine.

The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

Directory of Open Access Journals (Sweden)

Dong J

2013-03-01

Full Text Available Jingjing Dong,1,* Geng Cui,2,* Long Bi,1,* Jie Li,3 Wei Lei11Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Institute of Orthopedics, General Hospital of PLA, Beijing, People’s Republic of China; 3Institute of Gynecology and Obstetrics, General Hospital of PLA, Beijing, People’s Republic of China*These authors contributed equally to this workAbstract: In order to improve the mechanical and biological properties of calcium phosphate cement (CPC, nanometer-biomaterial for bone reconstruction in the rabbit femoral defect model, fibrin glue (FG, the natural product, purified from the blood was introduced at three different ratios. The CPC powder and the FG solution were mixed, respectively, at the powder/liquid (P/L ratios (g/mL of 1:1, 3:1, and 5:1 (g/mL, and pure CPC was used as a control. After being implanted into the femoral defect in rabbit, the healing process was evaluated by micro-computed tomography scan, biomechanical testing, and histological examination. By micro-computed tomography analysis, the P/L ratio of 1:1 (g/mL group indicated the largest quantity of new bone formation at 4 weeks, 8 weeks, and 12 weeks after implantation, respectively. Bone volume per trabecular volume of the 1:1 group was highest in the four groups, which was 1.45% ± 0.42%, 7.35% ± 1.45%, and 29.10% ± 1.67% at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the biomechanical tests, the compressive strength and the elastic modulus of the three CPC–FG groups were much higher than those of the pure CPC group at the determined time point (P < 0.05. The histological evaluation also showed the best osseointegration in the 1:1 group at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the 1:1 group, the bone grew into the pore of the cement in the laminar arrangement and connected with the cement tightly at the 12th week after the operation

A non-linear and stochastic response surface method for Bayesian estimation of uncertainty in soil moisture simulation from a land surface model

Directory of Open Access Journals (Sweden)

F. Hossain

2004-01-01

Full Text Available This study presents a simple and efficient scheme for Bayesian estimation of uncertainty in soil moisture simulation by a Land Surface Model (LSM. The scheme is assessed within a Monte Carlo (MC simulation framework based on the Generalized Likelihood Uncertainty Estimation (GLUE methodology. A primary limitation of using the GLUE method is the prohibitive computational burden imposed by uniform random sampling of the model's parameter distributions. Sampling is improved in the proposed scheme by stochastic modeling of the parameters' response surface that recognizes the non-linear deterministic behavior between soil moisture and land surface parameters. Uncertainty in soil moisture simulation (model output is approximated through a Hermite polynomial chaos expansion of normal random variables that represent the model's parameter (model input uncertainty. The unknown coefficients of the polynomial are calculated using limited number of model simulation runs. The calibrated polynomial is then used as a fast-running proxy to the slower-running LSM to predict the degree of representativeness of a randomly sampled model parameter set. An evaluation of the scheme's efficiency in sampling is made through comparison with the fully random MC sampling (the norm for GLUE and the nearest-neighborhood sampling technique. The scheme was able to reduce computational burden of random MC sampling for GLUE in the ranges of 10%-70%. The scheme was also found to be about 10% more efficient than the nearest-neighborhood sampling method in predicting a sampled parameter set's degree of representativeness. The GLUE based on the proposed sampling scheme did not alter the essential features of the uncertainty structure in soil moisture simulation. The scheme can potentially make GLUE uncertainty estimation for any LSM more efficient as it does not impose any additional structural or distributional assumptions.

Pandemic influenza preparedness: an ethical framework to guide decision-making

Directory of Open Access Journals (Sweden)

Gibson Jennifer L

2006-12-01

Full Text Available Abstract Background Planning for the next pandemic influenza outbreak is underway in hospitals across the world. The global SARS experience has taught us that ethical frameworks to guide decision-making may help to reduce collateral damage and increase trust and solidarity within and between health care organisations. Good pandemic planning requires reflection on values because science alone cannot tell us how to prepare for a public health crisis. Discussion In this paper, we present an ethical framework for pandemic influenza planning. The ethical framework was developed with expertise from clinical, organisational and public health ethics and validated through a stakeholder engagement process. The ethical framework includes both substantive and procedural elements for ethical pandemic influenza planning. The incorporation of ethics into pandemic planning can be helped by senior hospital administrators sponsoring its use, by having stakeholders vet the framework, and by designing or identifying decision review processes. We discuss the merits and limits of an applied ethical framework for hospital decision-making, as well as the robustness of the framework. Summary The need for reflection on the ethical issues raised by the spectre of a pandemic influenza outbreak is great. Our efforts to address the normative aspects of pandemic planning in hospitals have generated interest from other hospitals and from the governmental sector. The framework will require re-evaluation and refinement and we hope that this paper will generate feedback on how to make it even more robust.

Equifinality of formal (DREAM) and informal (GLUE) Bayesian approaches in hydrologic modeling?

NARCIS (Netherlands)

Vrugt, J.A.; ter Braak, C.J.F.; Gupta, H.V.; Robinson, B.A.

2009-01-01

In recent years, a strong debate has emerged in the hydrologic literature regarding what constitutes an appropriate framework for uncertainty estimation. Particularly, there is strong disagreement whether an uncertainty framework should have its roots within a proper statistical (Bayesian) context,

Analyzing Data Generated Through Deliberative Dialogue: Bringing Knowledge Translation Into Qualitative Analysis.

Science.gov (United States)

Plamondon, Katrina M; Bottorff, Joan L; Cole, Donald C

2015-11-01

Deliberative dialogue (DD) is a knowledge translation strategy that can serve to generate rich data and bridge health research with action. An intriguing alternative to other modes of generating data, the purposeful and evidence-informed conversations characteristic of DD generate data inclusive of collective interpretations. These data are thus dialogic, presenting complex challenges for qualitative analysis. In this article, we discuss the nature of data generated through DD, orienting ourselves toward a theoretically grounded approach to analysis. We offer an integrated framework for analysis, balancing analytical strategies of categorizing and connecting with the use of empathetic and suspicious interpretive lenses. In this framework, data generation and analysis occur in concert, alongside engaging participants and synthesizing evidence. An example of application is provided, demonstrating nuances of the framework. We conclude with reflections on the strengths and limitations of the framework, suggesting how it may be relevant in other qualitative health approaches. © The Author(s) 2015.

A New Generation of Leaching Tests – The Leaching Environmental Assessment Framework

Science.gov (United States)

Provides an overview of newly released leaching tests that provide a more accurate source term when estimating environmental release of metals and other constituents of potential concern (COPCs). The Leaching Environmental Assessment Framework (LEAF) methods have been (1) develo...

Porous Hydrogen-Bonded Organic Frameworks

Directory of Open Access Journals (Sweden)

Yi-Fei Han

2017-02-01

Full Text Available Ordered porous solid-state architectures constructed via non-covalent supramolecular self-assembly have attracted increasing interest due to their unique advantages and potential applications. Porous metal-coordination organic frameworks (MOFs are generated by the assembly of metal coordination centers and organic linkers. Compared to MOFs, porous hydrogen-bonded organic frameworks (HOFs are readily purified and recovered via simple recrystallization. However, due to lacking of sufficiently ability to orientate self-aggregation of building motifs in predictable manners, rational design and preparation of porous HOFs are still challenging. Herein, we summarize recent developments about porous HOFs and attempt to gain deeper insights into the design strategies of basic building motifs.

ForEx++: A New Framework for Knowledge Discovery from Decision Forests

Directory of Open Access Journals (Sweden)

Md Nasim Adnan

2017-11-01

Full Text Available Decision trees are popularly used in a wide range of real world problems for both prediction and classification (logic rules discovery. A decision forest is an ensemble of decision trees and it is often built for achieving better predictive performance compared to a single decision tree. Besides improving predictive performance, a decision forest can be seen as a pool of logic rules (rules with great potential for knowledge discovery. However, a standard-sized decision forest usually generates a large number of rules that a user may not able to manage for effective knowledge analysis. In this paper, we propose a new, data set independent framework for extracting those rules that are comparatively more accurate, generalized and concise than others. We apply the proposed framework on rules generated by two different decision forest algorithms from some publicly available medical related data sets on dementia and heart disease. We then compare the quality of rules extracted by the proposed framework with rules generated from a single J48 decision tree and rules extracted by another recent method. The results reported in this paper demonstrate the effectiveness of the proposed framework.

Graph Generator Survey

Energy Technology Data Exchange (ETDEWEB)

Lothian, Joshua [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Powers, Sarah S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sullivan, Blair D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Baker, Matthew B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schrock, Jonathan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Poole, Stephen W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2013-10-01

The benchmarking effort within the Extreme Scale Systems Center at Oak Ridge National Laboratory seeks to provide High Performance Computing benchmarks and test suites of interest to the DoD sponsor. The work described in this report is a part of the effort focusing on graph generation. A previously developed benchmark, SystemBurn, allowed the emulation of different application behavior profiles within a single framework. To complement this effort, similar capabilities are desired for graph-centric problems. This report examines existing synthetic graph generator implementations in preparation for further study on the properties of their generated synthetic graphs.

Generations and the Generation of Theory in Social Gerontology.

Science.gov (United States)

Hendricks, Jon

1992-01-01

Looks at theorizing in gerontology as career-related activity engaged in by scholars who are prone to same demographic imperatives as other human beings as way of shedding more light on many uses of theory. Uses concept of theoretical generations as means of accounting for succession of models and explanatory frameworks. (Author/NB)

A novel optimal distribution system planning framework implementing distributed generation in a deregulated electricity market

International Nuclear Information System (INIS)

Porkar, S.; Poure, P.; Abbaspour-Tehrani-fard, A.; Saadate, S.

2010-01-01

This paper introduces a new framework included mathematical model and a new software package interfacing two powerful softwares (MATLAB and GAMS) for obtaining the optimal distributed generation (DG) capacity sizing and sitting investments with capability to simulate large distribution system planning. The proposed optimization model allows minimizing total system planning costs for DG investment, DG operation and maintenance, purchase of power by the distribution companies (DISCOs) from transmission companies (TRANSCOs) and system power losses. The proposed model provides not only the DG size and site but also the new market price as well. Three different cases depending on system conditions and three different scenarios depending on different planning alternatives and electrical market structures, have been considered. They have allowed validating the economical and electrical benefits of introducing DG by solving the distribution system planning problem and by improving power quality of distribution system. DG installation increases the feeders' lifetime by reducing their loading and adds the benefit of using the existing distribution system for further load growth without the need for feeders upgrading. More, by investing in DG, the DISCO can minimize its total planning cost and reduce its customers' bills. (author)

A novel optimal distribution system planning framework implementing distributed generation in a deregulated electricity market

Energy Technology Data Exchange (ETDEWEB)

Porkar, S. [Department of Electrical Engineering, Sharif University of Technology, Tehran (Iran); Groupe de Recherches en Electrotechnique et Electronique de Nancy, GREEN-UHP, Universite Henri Poincare de Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex (France); Poure, P. [Laboratoire d' Instrumentation Electronique de Nancy, LIEN, EA 3440, Universite Henri Poincare de Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex (France); Abbaspour-Tehrani-fard, A. [Department of Electrical Engineering, Sharif University of Technology, Tehran (Iran); Saadate, S. [Groupe de Recherches en Electrotechnique et Electronique de Nancy, GREEN-UHP, Universite Henri Poincare de Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex (France)

2010-07-15

This paper introduces a new framework included mathematical model and a new software package interfacing two powerful softwares (MATLAB and GAMS) for obtaining the optimal distributed generation (DG) capacity sizing and sitting investments with capability to simulate large distribution system planning. The proposed optimization model allows minimizing total system planning costs for DG investment, DG operation and maintenance, purchase of power by the distribution companies (DISCOs) from transmission companies (TRANSCOs) and system power losses. The proposed model provides not only the DG size and site but also the new market price as well. Three different cases depending on system conditions and three different scenarios depending on different planning alternatives and electrical market structures, have been considered. They have allowed validating the economical and electrical benefits of introducing DG by solving the distribution system planning problem and by improving power quality of distribution system. DG installation increases the feeders' lifetime by reducing their loading and adds the benefit of using the existing distribution system for further load growth without the need for feeders upgrading. More, by investing in DG, the DISCO can minimize its total planning cost and reduce its customers' bills. (author)

Service quality framework for clinical laboratories.

Science.gov (United States)

Ramessur, Vinaysing; Hurreeram, Dinesh Kumar; Maistry, Kaylasson

2015-01-01

The purpose of this paper is to illustrate a service quality framework that enhances service delivery in clinical laboratories by gauging medical practitioner satisfaction and by providing avenues for continuous improvement. The case study method has been used for conducting the exploratory study, with focus on the Mauritian public clinical laboratory. A structured questionnaire based on the SERVQUAL service quality model was used for data collection, analysis and for the development of the service quality framework. The study confirms the pertinence of the following service quality dimensions within the context of clinical laboratories: tangibility, reliability, responsiveness, turnaround time, technology, test reports, communication and laboratory staff attitude and behaviour. The service quality framework developed, termed LabSERV, is vital for clinical laboratories in the search for improving service delivery to medical practitioners. This is a pioneering work carried out in the clinical laboratory sector in Mauritius. Medical practitioner expectations and perceptions have been simultaneously considered to generate a novel service quality framework for clinical laboratories.

Steam Generator tube integrity -- US Nuclear Regulatory Commission perspective

International Nuclear Information System (INIS)

Murphy, E.L.; Sullivan, E.J.

1997-01-01

In the US, the current regulatory framework was developed in the 1970s when general wall thinning was the dominant degradation mechanism; and, as a result of changes in the forms of degradation being observed and improvements in inspection and tube repair technology, the regulatory framework needs to be updated. Operating experience indicates that the current U.S. requirements should be more stringent in some areas, while in other areas they are overly conservative. To date, this situation has been dealt with on a plant-specific basis in the US. However, the NRC staff is now developing a proposed steam generator rule as a generic framework for ensuring that the steam generator tubes are capable of performing their intended safety functions. This paper discusses the current U.S. regulatory framework for assuring steam generator (SG) tube integrity, the need to update this regulatory framework, the objectives of the new proposed rule, the US Nuclear Regulatory Commission (NRC) regulatory guide (RG) that will accompany the rule, how risk considerations affect the development of the new rule, and some outstanding issues relating to the rule that the NRC is still dealing with

Generative Contexts: Generating value between community and educational settings

Directory of Open Access Journals (Sweden)

Dan Lyles

2016-12-01

Full Text Available As educators and researchers, the authors of this paper participated, at different points in time, in a National Science Foundation funded research program to place culturally responsive education into generative justice frameworks. We discovered that the mechanisms to create generative contexts—contexts where value can possibly be returned to the community where the people generating that value live and work—in-school, after-school, and not-school were not uniform and required individual attention and care. One can think of generative contexts as the educational preconditions for generative justice. We aim to show how generative contexts are crucial to understanding a larger theory of generative justice. To do this we provide three examples of generative contexts. First is a generative context in-school, where a technology teacher brought a community hairstylist into her classroom to help teach computer programming through cornrow braiding; a skill relevant to her African American students. Next is a generative context after-school where a student demonstrates soldering skills that she learned from family members. The third is a not-school “E-Waste to Makerspace” workshop where students created garden-technology designs for low-income communities. 

Discursive biases of the environmental research framework DPSIR

DEFF Research Database (Denmark)

Svarstad, Hanne; Petersen, Lars Kjerulf; Rothman, Dale

2008-01-01

a critical examination of theoretical foundations of the DPSIR approach. We focus on the example of biodiversity, but our conclusions are relevant to other fields of environmental research. The DPSIR framework is viewed through the ‘lenses' of four major types of discourses on biodiversity: Preservationist......, Win-win, Traditionalist and Promethean. Based upon this examination, we argue that the DPSIR framework is not a tool generating neutral knowledge. Instead, application of this framework reproduces the discursive positions the applicant brings into it. We find that when applied in its traditional form...... to studies in the field of biodiversity, the framework is most compatible with the Preservationist discourse type and tends to favour conservationist and to neglect other positions. Thus, contrary to what is often claimed, we find that the DPSIR framework has shortcomings as a tool for establishing good...

Context-aware System Service Call-oriented Symbolic Execution of Android Framework with Application to Exploit Generation

OpenAIRE

Luo, Lannan; Zeng, Qiang; Cao, Chen; Chen, Kai; Liu, Jian; Liu, Limin; Gao, Neng; Yang, Min; Xing, Xinyu; Liu, Peng

2016-01-01

Android Framework is a layer of software that exists in every Android system managing resources of all Android apps. A vulnerability in Android Framework can lead to severe hacks, such as destroying user data and leaking private information. With tens of millions of Android devices unpatched due to Android fragmentation, vulnerabilities in Android Framework certainly attract attackers to exploit them. So far, enormous manual effort is needed to craft such exploits. To our knowledge, no resear...

My-Forensic-Loci-queries (MyFLq) framework for analysis of forensic STR data generated by massive parallel sequencing.

Science.gov (United States)

Van Neste, Christophe; Vandewoestyne, Mado; Van Criekinge, Wim; Deforce, Dieter; Van Nieuwerburgh, Filip

2014-03-01

Forensic scientists are currently investigating how to transition from capillary electrophoresis (CE) to massive parallel sequencing (MPS) for analysis of forensic DNA profiles. MPS offers several advantages over CE such as virtually unlimited multiplexy of loci, combining both short tandem repeat (STR) and single nucleotide polymorphism (SNP) loci, small amplicons without constraints of size separation, more discrimination power, deep mixture resolution and sample multiplexing. We present our bioinformatic framework My-Forensic-Loci-queries (MyFLq) for analysis of MPS forensic data. For allele calling, the framework uses a MySQL reference allele database with automatically determined regions of interest (ROIs) by a generic maximal flanking algorithm which makes it possible to use any STR or SNP forensic locus. Python scripts were designed to automatically make allele calls starting from raw MPS data. We also present a method to assess the usefulness and overall performance of a forensic locus with respect to MPS, as well as methods to estimate whether an unknown allele, which sequence is not present in the MySQL database, is in fact a new allele or a sequencing error. The MyFLq framework was applied to an Illumina MiSeq dataset of a forensic Illumina amplicon library, generated from multilocus STR polymerase chain reaction (PCR) on both single contributor samples and multiple person DNA mixtures. Although the multilocus PCR was not yet optimized for MPS in terms of amplicon length or locus selection, the results show excellent results for most loci. The results show a high signal-to-noise ratio, correct allele calls, and a low limit of detection for minor DNA contributors in mixed DNA samples. Technically, forensic MPS affords great promise for routine implementation in forensic genomics. The method is also applicable to adjacent disciplines such as molecular autopsy in legal medicine and in mitochondrial DNA research. Copyright © 2013 The Authors. Published by

Dynamic constitutional frameworks for DNA biomimetic recognition.

Science.gov (United States)

Catana, Romina; Barboiu, Mihail; Moleavin, Ioana; Clima, Lilia; Rotaru, Alexandru; Ursu, Elena-Laura; Pinteala, Mariana

2015-02-07

Linear and cross-linked dynamic constitutional frameworks generated from reversibly interacting linear PEG/core constituents and cationic sites shed light on the dominant coiling versus linear DNA binding behaviours, closer to the histone DNA binding wrapping mechanism.

Coherent mixing in three and four quark generations

OpenAIRE

Simonov, Yu. A.

2010-01-01

New dynamical mechanism of quark mass generations and mixing is demonstrated in the examples of three and four generations. In the framework of the new mixing pattern, called the coherent mixing, the CKM elements are predicted compatible with experimental data for three generations, and are strongly constrained for four generations.

Rule-based Test Generation with Mind Maps

Directory of Open Access Journals (Sweden)

Dimitry Polivaev

2012-02-01

Full Text Available This paper introduces basic concepts of rule based test generation with mind maps, and reports experiences learned from industrial application of this technique in the domain of smart card testing by Giesecke & Devrient GmbH over the last years. It describes the formalization of test selection criteria used by our test generator, our test generation architecture and test generation framework.

A Run-Time Verification Framework for Smart Grid Applications Implemented on Simulation Frameworks

Energy Technology Data Exchange (ETDEWEB)

Ciraci, Selim; Sozer, Hasan; Tekinerdogan, Bedir

2013-05-18

Smart grid applications are implemented and tested with simulation frameworks as the developers usually do not have access to large sensor networks to be used as a test bed. The developers are forced to map the implementation onto these frameworks which results in a deviation between the architecture and the code. On its turn this deviation makes it hard to verify behavioral constraints that are de- scribed at the architectural level. We have developed the ConArch toolset to support the automated verification of architecture-level behavioral constraints. A key feature of ConArch is programmable mapping for architecture to the implementation. Here, developers implement queries to identify the points in the target program that correspond to architectural interactions. ConArch generates run- time observers that monitor the flow of execution between these points and verifies whether this flow conforms to the behavioral constraints. We illustrate how the programmable mappings can be exploited for verifying behavioral constraints of a smart grid appli- cation that is implemented with two simulation frameworks.

A framework for social investment strategies

DEFF Research Database (Denmark)

Kvist, Jon

2015-01-01

and multidimensional nature of social issues and social investments. Theoretically, this article establishes such a framework consisting of generational, life course and gender perspectives on social investments. The generational perspective brings out that social investments involve horizontal redistribution......, underpin the productive and reproductive social contract between generations, and the increased diversity within generations. The life course perspective demonstrates how social issues and social investments in one life stage depend on the situation in prior life stages and affect the situation in later...... life stages and, possibly, in multiple dimensions. The gender perspective shows how social investments can improve economic and social returns when gender and ageing over the life course are taken into consideration. Empirically, cross-national patterns indicate a positive relation between social...

Endoscopic debridement and fibrin glue injection of a chronic Morel-Lavallée lesion of the knee in a professional soccer player: A case report and literature review.

Science.gov (United States)

Koc, Baris B; Somorjai, Nicolaas; P M Kiesouw, Egid; Vanderdood, Kurt; Meesters-Caberg, Marleen; Draijer, Frits W; Jansen, Edwin J P

2017-01-01

A Morel-Lavallée lesion is a post-traumatic closed degloving injury of soft tissue. The lesion is due to a shearing trauma with separation of subcutaneous tissue from underlying fascia. When conservative treatment fails, surgical treatment is imperative. Commonly, open drainage and debridement is performed. This case report describes a Morel-Lavallée lesion of the knee in a professional soccer player who was successfully treated with endoscopic debridement and fibrin glue injection after failure of conservative management. This method achieves the goal of an open surgical debridement without exposing patients to an increased morbidity. Copyright © 2016. Published by Elsevier B.V.

Fuel upgrading and reforming with metal organic framework

KAUST Repository

Eddaoudi, Mohamed

2016-03-31

Systems and methods for separating hydrocarbons on an internal combustion powered vehicle via one or more metal organic frameworks are disclosed. Systems and methods can further include utilizing separated hydrocarbons and exhaust to generate hydrogen gas for use as fuel. In one aspect, a method for separating hydrocarbons can include contacting a first component containing a first metal organic framework with a flow of hydrocarbons and separating hydrocarbons by size. In certain embodiments, the hydrocarbons can include alkanes.

A Hybrid Programming Framework for Modeling and Solving Constraint Satisfaction and Optimization Problems

Directory of Open Access Journals (Sweden)

Paweł Sitek

2016-01-01

Full Text Available This paper proposes a hybrid programming framework for modeling and solving of constraint satisfaction problems (CSPs and constraint optimization problems (COPs. Two paradigms, CLP (constraint logic programming and MP (mathematical programming, are integrated in the framework. The integration is supplemented with the original method of problem transformation, used in the framework as a presolving method. The transformation substantially reduces the feasible solution space. The framework automatically generates CSP and COP models based on current values of data instances, questions asked by a user, and set of predicates and facts of the problem being modeled, which altogether constitute a knowledge database for the given problem. This dynamic generation of dedicated models, based on the knowledge base, together with the parameters changing externally, for example, the user’s questions, is the implementation of the autonomous search concept. The models are solved using the internal or external solvers integrated with the framework. The architecture of the framework as well as its implementation outline is also included in the paper. The effectiveness of the framework regarding the modeling and solution search is assessed through the illustrative examples relating to scheduling problems with additional constrained resources.

Molecule database framework: a framework for creating database applications with chemical structure search capability.

Science.gov (United States)

Kiener, Joos

2013-12-11

Research in organic chemistry generates samples of novel chemicals together with their properties and other related data. The involved scientists must be able to store this data and search it by chemical structure. There are commercial solutions for common needs like chemical registration systems or electronic lab notebooks. However for specific requirements of in-house databases and processes no such solutions exist. Another issue is that commercial solutions have the risk of vendor lock-in and may require an expensive license of a proprietary relational database management system. To speed up and simplify the development for applications that require chemical structure search capabilities, I have developed Molecule Database Framework. The framework abstracts the storing and searching of chemical structures into method calls. Therefore software developers do not require extensive knowledge about chemistry and the underlying database cartridge. This decreases application development time. Molecule Database Framework is written in Java and I created it by integrating existing free and open-source tools and frameworks. The core functionality includes:•Support for multi-component compounds (mixtures)•Import and export of SD-files•Optional security (authorization)For chemical structure searching Molecule Database Framework leverages the capabilities of the Bingo Cartridge for PostgreSQL and provides type-safe searching, caching, transactions and optional method level security. Molecule Database Framework supports multi-component chemical compounds (mixtures).Furthermore the design of entity classes and the reasoning behind it are explained. By means of a simple web application I describe how the framework could be used. I then benchmarked this example application to create some basic performance expectations for chemical structure searches and import and export of SD-files. By using a simple web application it was shown that Molecule Database Framework

A Framework for the Design of Effective Graphics for Scientific Visualization

Science.gov (United States)

Miceli, Kristina D.

1992-01-01

This proposal presents a visualization framework, based on a data model, that supports the production of effective graphics for scientific visualization. Visual representations are effective only if they augment comprehension of the increasing amounts of data being generated by modern computer simulations. These representations are created by taking into account the goals and capabilities of the scientist, the type of data to be displayed, and software and hardware considerations. This framework is embodied in an assistant-based visualization system to guide the scientist in the visualization process. This will improve the quality of the visualizations and decrease the time the scientist is required to spend in generating the visualizations. I intend to prove that such a framework will create a more productive environment for tile analysis and interpretation of large, complex data sets.

Fuel upgrading and reforming with metal organic framework

KAUST Repository

Eddaoudi, Mohamed; Belmabkhout, Youssef

2016-01-01

Systems and methods for separating hydrocarbons on an internal combustion powered vehicle via one or more metal organic frameworks are disclosed. Systems and methods can further include utilizing separated hydrocarbons and exhaust to generate

A quality framework for addiction treatment programs

NARCIS (Netherlands)

Nabitz, Udo; van den Brink, Wim; Walburg, Jan

2005-01-01

AIM: To identify and specify the structure and the elements of a quality framework for addiction treatment programs. METHOD: Concept mapping strategy was applied. In brainstorm sessions, 70 statements were generated and rated by 90 representatives of three stakeholder groups. Using multivariate

SDN-Enabled Communication Network Framework for Energy Internet

Directory of Open Access Journals (Sweden)

Zhaoming Lu

2017-01-01

Full Text Available To support distributed energy generators and improve energy utilization, energy Internet has attracted global research focus. In China, energy Internet has been proposed as an important issue of government and institutes. However, managing a large amount of distributed generators requires smart, low-latency, reliable, and safe networking infrastructure, which cannot be supported by traditional networks in power grids. In order to design and construct smart and flexible energy Internet, we proposed a software defined network framework with both microgrid cluster level and global grid level designed by a hierarchical manner, which will bring flexibility, efficiency, and reliability for power grid networks. Finally, we evaluate and verify the performance of this framework in terms of latency, reliability, and security by both theoretical analysis and real-world experiments.

An icy-glue model of cometary nuclei

International Nuclear Information System (INIS)

Gombosi, T.I.; Houpis, H.L.F.

1986-05-01

Since 1950 a number of models have been proposed to explain the observations of comets. For the most part the icy conglomerate model of Whipple was the standard. Based on the recent images made by VEGA and GIOTTO spacecrafts of comet Halley, a model of the nucleus is suggested that retains the advantages of the icy conglomerate formalism on a local level, while a new global framework is introduced. The model is disscussed in terms of the mounting knowledge of comets, the creation of the nucleus in the cosmogenic sence, and expectations of future analysis of data and observations are presented. A new methodology for calculating the evolution and thermal profiles of the nucleus is also presented. (author)

LanguageNet: A Novel Framework for Processing Unstructured Text Information

DEFF Research Database (Denmark)

Qureshi, Pir Abdul Rasool; Memon, Nasrullah; Wiil, Uffe Kock

2011-01-01

In this paper we present LanguageNet—a novel framework for processing unstructured text information from human generated content. The state of the art information processing frameworks have some shortcomings: modeled in generalized form, trained on fixed (limited) data sets, and leaving...... the specialization necessary for information consolidation to the end users. The proposed framework is the first major attempt to address these shortcomings. LanguageNet provides extended support of graphical methods contributing added value to the capabilities of information processing. We discuss the benefits...... of the framework and compare it with the available state of the art. We also describe how the framework improves the information gathering process and contribute towards building systems with better performance in the domain of Open Source Intelligence....

Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells

Directory of Open Access Journals (Sweden)

Tamer Anwar Esmail Ahmed

2015-02-01

Full Text Available The retina is a highly sophisticated piece of the neural machinery that begins the translation of incoming light signals into meaningful visual information. Several degenerative diseases of the retina are characterized by photoreceptor loss and eventually lead to irreversible blindness. Regenerative medicine, using tissue engineering-based constructs to deliver progenitor cells or photoreceptors along with supporting carrier matrix is a promising approach for restoration of structure and function. Fresh fibrin glue (FG produced by the CryoSeal®FS system in combination with mouse retinal progenitor cells (RPCs were evaluated in this study. In vitro expanded RPCs isolated from postnatal mouse retina were encapsulated into FG and cultured in the presence of the protease inhibitor, tranexamic acid. Encapsulation of RPCs into FG did not show adverse effects on cell proliferation or cell survival. RPCs exhibited fibroblast-like morphology concomitantly with attachment to the encapsulating FG surface. They expressed α7 and β3 integrin subunits that could mediate attachment to fibrin matrix via an RGD independent mechanism. The three dimensional environment and the attachment surface provided by FG was associated with a rapid downregulation of the progenitor marker SOX2 and enhanced the expression of the differentiation markers CRX and recoverin. However, the in vitro culture conditions did not promote full differentiation into mature photoreceptors. Nevertheless, we have shown that autologous fibrin, when fabricated into a scaffold for RPCs for delivery to the retina, provides the cells with external cues that could potentially improve the differentiation events. Hence, transient encapsulation of RPCs into FG could be a valid and potential treatment strategy to promote retinal regeneration following degenerative diseases. However, further optimization is necessary to maximize the outcomes in terms of mature photoreceptors.

CoordSS: An Ontology Framework for Heterogeneous Networks Experimentation

Directory of Open Access Journals (Sweden)

V. Nejkovic

2016-11-01

Full Text Available Experimenting with HetNets environments is of importance because of the role that such environments have in next-generation cellular networks. In this paper, the CoordSS ontology experimentation framework is proposed with an aim to support experimenting with HetNets environments on wireless networking testbeds. In the framework, domain and system ontologies are adopted for formal representation of the knowledge about the context of the problem. This paper outlines implementation details of ontologies in the CoordSS experimentation framework. The synergy between semantic and cognitive computing is introduced as the theoretical foundation of the paper.

Computer-Aided Modeling Framework

DEFF Research Database (Denmark)

Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

Models are playing important roles in design and analysis of chemicals based products and the processes that manufacture them. Computer-aided methods and tools have the potential to reduce the number of experiments, which can be expensive and time consuming, and there is a benefit of working...... development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...

Exploiting large-pore metal-organic frameworks for separations through entropic molecular mechanisms

NARCIS (Netherlands)

Torres-Knoop, A.; Dubbeldam, D.

2015-01-01

We review the molecular mechanisms behind adsorption and the separations of mixtures in metal-organic frameworks and zeolites. Separation mechanisms can be based on differences in the affinity of the adsorbate with the framework and on entropic effects. To develop next-generation adsorbents, the

A framework for investigating the interactions between climate, dust, solar power generation and water desalination processes in Desert Climate

Science.gov (United States)

Siam, M. S.; Alqatari, S.; Ibrahim, H. D.; AlAloula, R. A.; Alrished, M.; AlSaati, A.; Eltahir, E. A. B.

2016-12-01

Increasing water demand in Saudi Arabia due to rapid population growth has forced the rapid expansion of seawater desalination plants in order to meet both current and future freshwater needs. Saudi Arabia has a huge potential for solar energy, hence, solar-powered desalination plants provide an opportunity to sustainably address the freshwater demand in the kingdom without relying on fossil fuels energy. However, the desert climate of Saudi Arabia and limited access to the open ocean imposes several challenges to the expansion and sustainability of solar-powered desalination plants. For example, the frequent and intense dust storms that occur in the region can degrade solar panels and significantly reduce their efficiency. Moreover, the high salinity Arabian Gulf is both the source of feedwater and sink of hypersaline discharge (brine) for many plants in the east of the Kingdom, and the brine may alter the salinity, temperature and movement of the water thereby reducing the quality of the feedwater to the desalination plants. Here, we propose a framework to investigate the different interactions between climate, dust, solar power generation and seawater desalination in order to identify optimal parameters such as locations of solar panels and seawater intake for sustainable implementation of solar-powered desalination plants. This framework integrates several numerical models including regional climate, hydrodynamics, Photovoltaics (PV) and Photovoltaic-Reverse Osmosis (PV-RO) models that are used to investigate these interactions for a solar-powered desalination plant at AlKhafji on the Northeastern coast of Saudi Arabia.

Task 4.1: Development of a framework for creating a databank to generate probability density functions for process parameters

International Nuclear Information System (INIS)

Burgazzi, Luciano

2011-01-01

PSA analysis should be based on the best available data for the types of equipment and systems in the plant. In some cases very limited data may be available for evolutionary designs or new equipments, especially in the case of passive systems. It has been recognized that difficulties arise in addressing the uncertainties related to the physical phenomena and characterizing the parameters relevant to the passive system performance evaluation, since the unavailability of a consistent operational and experimental data base. This lack of experimental evidence and validated data forces the analyst to resort to expert/engineering judgment to a large extent, thus making the results strongly dependent upon the expert elicitation process. This prompts the need for the development of a framework for constructing a database to generate probability distributions for the parameters influencing the system behaviour. The objective of the task is to develop a consistent framework aimed at creating probability distributions for the parameters relevant to the passive system performance evaluation. In order to achieve this goal considerable experience and engineering judgement are also required to determine which existing data are most applicable to the new systems or which generic data bases or models provide the best information for the system design. Eventually in case of absence of documented specific reliability data, documented expert judgement coming out from a well structured procedure could be used to envisage sound probability distributions for the parameters under interest

Towards Next Generation BI Systems

DEFF Research Database (Denmark)

Varga, Jovan; Romero, Oscar; Pedersen, Torben Bach

2014-01-01

Next generation Business Intelligence (BI) systems require integration of heterogeneous data sources and a strong user-centric orientation. Both needs entail machine-processable metadata to enable automation and allow end users to gain access to relevant data for their decision making processes....... This framework is based on the findings of a survey of current user-centric approaches mainly focusing on query recommendation assistance. Finally, we discuss the benefits of the framework and present the plans for future work....

Preliminary Framework for Human-Automation Collaboration

International Nuclear Information System (INIS)

Oxstrand, Johanna Helene; Le Blanc, Katya Lee; Spielman, Zachary Alexander

2015-01-01

The Department of Energy's Advanced Reactor Technologies Program sponsors research, development and deployment activities through its Next Generation Nuclear Plant, Advanced Reactor Concepts, and Advanced Small Modular Reactor (aSMR) Programs to promote safety, technical, economical, and environmental advancements of innovative Generation IV nuclear energy technologies. The Human Automation Collaboration (HAC) Research Project is located under the aSMR Program, which identifies developing advanced instrumentation and controls and human-machine interfaces as one of four key research areas. It is expected that the new nuclear power plant designs will employ technology significantly more advanced than the analog systems in the existing reactor fleet as well as utilizing automation to a greater extent. Moving towards more advanced technology and more automation does not necessary imply more efficient and safer operation of the plant. Instead, a number of concerns about how these technologies will affect human performance and the overall safety of the plant need to be addressed. More specifically, it is important to investigate how the operator and the automation work as a team to ensure effective and safe plant operation, also known as the human-automation collaboration (HAC). The focus of the HAC research is to understand how various characteristics of automation (such as its reliability, processes, and modes) effect an operator's use and awareness of plant conditions. In other words, the research team investigates how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. This report addresses the Department of Energy milestone M4AT-15IN2302054, Complete Preliminary Framework for Human-Automation Collaboration, by discussing the two phased development of a preliminary HAC framework. The framework developed in the first phase was used as

Preliminary Framework for Human-Automation Collaboration

Energy Technology Data Exchange (ETDEWEB)

Oxstrand, Johanna Helene [Idaho National Lab. (INL), Idaho Falls, ID (United States); Le Blanc, Katya Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States); Spielman, Zachary Alexander [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

The Department of Energy’s Advanced Reactor Technologies Program sponsors research, development and deployment activities through its Next Generation Nuclear Plant, Advanced Reactor Concepts, and Advanced Small Modular Reactor (aSMR) Programs to promote safety, technical, economical, and environmental advancements of innovative Generation IV nuclear energy technologies. The Human Automation Collaboration (HAC) Research Project is located under the aSMR Program, which identifies developing advanced instrumentation and controls and human-machine interfaces as one of four key research areas. It is expected that the new nuclear power plant designs will employ technology significantly more advanced than the analog systems in the existing reactor fleet as well as utilizing automation to a greater extent. Moving towards more advanced technology and more automation does not necessary imply more efficient and safer operation of the plant. Instead, a number of concerns about how these technologies will affect human performance and the overall safety of the plant need to be addressed. More specifically, it is important to investigate how the operator and the automation work as a team to ensure effective and safe plant operation, also known as the human-automation collaboration (HAC). The focus of the HAC research is to understand how various characteristics of automation (such as its reliability, processes, and modes) effect an operator’s use and awareness of plant conditions. In other words, the research team investigates how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. This report addresses the Department of Energy milestone M4AT-15IN2302054, Complete Preliminary Framework for Human-Automation Collaboration, by discussing the two phased development of a preliminary HAC framework. The framework developed in the first phase was used as the

Generative electronic background music system

Energy Technology Data Exchange (ETDEWEB)

Mazurowski, Lukasz [Faculty of Computer Science, West Pomeranian University of Technology in Szczecin, Zolnierska Street 49, Szczecin, PL (Poland)

2015-03-10

In this short paper-extended abstract the new approach to generation of electronic background music has been presented. The Generative Electronic Background Music System (GEBMS) has been located between other related approaches within the musical algorithm positioning framework proposed by Woller et al. The music composition process is performed by a number of mini-models parameterized by further described properties. The mini-models generate fragments of musical patterns used in output composition. Musical pattern and output generation are controlled by container for the mini-models - a host-model. General mechanism has been presented including the example of the synthesized output compositions.

Generative electronic background music system

International Nuclear Information System (INIS)

Mazurowski, Lukasz

2015-01-01

In this short paper-extended abstract the new approach to generation of electronic background music has been presented. The Generative Electronic Background Music System (GEBMS) has been located between other related approaches within the musical algorithm positioning framework proposed by Woller et al. The music composition process is performed by a number of mini-models parameterized by further described properties. The mini-models generate fragments of musical patterns used in output composition. Musical pattern and output generation are controlled by container for the mini-models - a host-model. General mechanism has been presented including the example of the synthesized output compositions

Large-scale DNA Barcode Library Generation for Biomolecule Identification in High-throughput Screens.

Science.gov (United States)

Lyons, Eli; Sheridan, Paul; Tremmel, Georg; Miyano, Satoru; Sugano, Sumio

2017-10-24

High-throughput screens allow for the identification of specific biomolecules with characteristics of interest. In barcoded screens, DNA barcodes are linked to target biomolecules in a manner allowing for the target molecules making up a library to be identified by sequencing the DNA barcodes using Next Generation Sequencing. To be useful in experimental settings, the DNA barcodes in a library must satisfy certain constraints related to GC content, homopolymer length, Hamming distance, and blacklisted subsequences. Here we report a novel framework to quickly generate large-scale libraries of DNA barcodes for use in high-throughput screens. We show that our framework dramatically reduces the computation time required to generate large-scale DNA barcode libraries, compared with a naїve approach to DNA barcode library generation. As a proof of concept, we demonstrate that our framework is able to generate a library consisting of one million DNA barcodes for use in a fragment antibody phage display screening experiment. We also report generating a general purpose one billion DNA barcode library, the largest such library yet reported in literature. Our results demonstrate the value of our novel large-scale DNA barcode library generation framework for use in high-throughput screening applications.

Idea and application of spectrum-generating SU(3) and SU(4)

International Nuclear Information System (INIS)

Bohm, A.; Teese, R.B.

1978-10-01

The basic ideas of the spectrum-generating SU(n) approach in particle physics are reviewed and the analogy is shown between this and the spectrum-generating method in atomic and molecular physics. The tests of this framework involving one-hadron processes are outlined and two tests of a fundamental relation of this framework (the Werle relation) are discussed. 32 references

A segmentation framework towards automatic generation of boost subvolumes for FDG-PET tumors: A digital phantom study

International Nuclear Information System (INIS)

Yang, Fei; Grigsby, Perry W.

2012-01-01

Potential benefits of administering nonuniform radiation dose to heterogeneous tumors imaged with FDG-PET have been widely demonstrated; whereas the number of discrete dose levels to be utilized and corresponding locations for prescription inside tumors vary significantly with current existing methods. In this paper, an automated and unsupervised segmentation framework constituted mainly by an image restoration mechanism based on variational decomposition and a voxel clustering scheme based on spectral clustering was presented towards partitioning FDG-PET imaged tumors into subvolumes characterized with the total intra-subvolume activity similarity and the total inter-subvolume activity dissimilarity being simultaneously maximized. Experiments to evaluate the proposed system were carried out with using FDG-PET data generated from a digital phantom that employed SimSET (Simulation System for Emission Tomography) to simulate PET acquisition of tumors. The obtained results show the feasibility of the proposed system in dividing FDG-PET imaged tumor volumes into subvolumes with intratumoral heterogeneity being properly characterized, irrespective of variation in tumor morphology as well as diversity in intratumoral heterogeneity pattern.

Spring Framework 5: Themes & Trends

CERN Document Server

CERN. Geneva

2017-01-01

Spring Framework 5.0/5.1, scheduled for release in early/late 2017, focuses on several key themes: reactive web applications based on Reactive Streams, comprehensive support for JDK 9 and HTTP/2, as well as the latest API generations in the Enterprise Java ecosystem. This talk presents the overall story in the context of wider industry trends, highlighting Spring’s unique programming model strategy.

Generation capacity expansion planning in deregulated electricity markets

Science.gov (United States)

Sharma, Deepak

With increasing demand of electric power in the context of deregulated electricity markets, a good strategic planning for the growth of the power system is critical for our tomorrow. There is a need to build new resources in the form of generation plants and transmission lines while considering the effects of these new resources on power system operations, market economics and the long-term dynamics of the economy. In deregulation, the exercise of generation planning has undergone a paradigm shift. The first stage of generation planning is now undertaken by the individual investors. These investors see investments in generation capacity as an increasing business opportunity because of the increasing market prices. Therefore, the main objective of such a planning exercise, carried out by individual investors, is typically that of long-term profit maximization. This thesis presents some modeling frameworks for generation capacity expansion planning applicable to independent investor firms in the context of power industry deregulation. These modeling frameworks include various technical and financing issues within the process of power system planning. The proposed modeling frameworks consider the long-term decision making process of investor firms, the discrete nature of generation capacity addition and incorporates transmission network modeling. Studies have been carried out to examine the impact of the optimal investment plans on transmission network loadings in the long-run by integrating the generation capacity expansion planning framework within a modified IEEE 30-bus transmission system network. The work assesses the importance of arriving at an optimal IRR at which the firm's profit maximization objective attains an extremum value. The mathematical model is further improved to incorporate binary variables while considering discrete unit sizes, and subsequently to include the detailed transmission network representation. The proposed models are novel in the

METAMODELS OF INFORMATION TECHNOLOGY BEST PRACTICES FRAMEWORKS

Directory of Open Access Journals (Sweden)

Arthur Nunes Ferreira Neto

2011-12-01

Full Text Available This article deals with the generation and application of ontological metamodels of frameworks of best practices in IT. The ontological metamodels represent the logical structures and fundamental semantics of framework models and constitute adequate tools for the analysis, adaptation, comparison and integration of the frameworks of best practices in IT. The MetaFrame methodology for the construction of the metamodels, founded on the discipline of the conceptual metamodelling and on the extended Entity/Relationship methodology is described herein, as well as the metamodels of the best practices for the outsourcing of IT, the eSCM-SP v2.01 (eSourcing Capability Model for Service Providers and the eSCM-CL v1.1 (eSourcing Capability Model for Client Organizations, constructed according to the MetaFrame methodology.

gCSP occam Code Generation for RMoX

NARCIS (Netherlands)

Groothuis, M.A.; Liet, Geert K.; Broenink, Johannes F.; Roebbers, H.W.; Sunter, J.P.E.; Welch, P.H.; Wood, D.C.

2005-01-01

gCSP is a graphical tool for creating and editing CSP diagrams. gCSP is used in our labs to generate the embedded software framework for our control systems. As a further extension to our gCSP tool, an occam code generator has been constructed. Generating occam from CSP diagrams gives opportunities

Pythoscape: a framework for generation of large protein similarity networks.

Science.gov (United States)

Barber, Alan E; Babbitt, Patricia C

2012-11-01

Pythoscape is a framework implemented in Python for processing large protein similarity networks for visualization in other software packages. Protein similarity networks are graphical representations of sequence, structural and other similarities among proteins for which pairwise all-by-all similarity connections have been calculated. Mapping of biological and other information to network nodes or edges enables hypothesis creation about sequence-structure-function relationships across sets of related proteins. Pythoscape provides several options to calculate pairwise similarities for input sequences or structures, applies filters to network edges and defines sets of similar nodes and their associated data as single nodes (termed representative nodes) for compression of network information and output data or formatted files for visualization.

Utilizing the National Research Council's (NRC) Conceptual Framework for the Next Generation Science Standards (NGSS): A Self-Study in My Science, Engineering, and Mathematics Classroom

Science.gov (United States)

Corvo, Arthur Francis

Given the reality that active and competitive participation in the 21 st century requires American students to deepen their scientific and mathematical knowledge base, the National Research Council (NRC) proposed a new conceptual framework for K--12 science education. The framework consists of an integration of what the NRC report refers to as the three dimensions: scientific and engineering practices, crosscutting concepts, and core ideas in four disciplinary areas (physical, life and earth/spaces sciences, and engineering/technology). The Next Generation Science Standards (NGSS ), which are derived from this new framework, were released in April 2013 and have implications on teacher learning and development in Science, Technology, Engineering, and Mathematics (STEM). Given the NGSS's recent introduction, there is little research on how teachers can prepare for its release. To meet this research need, I implemented a self-study aimed at examining my teaching practices and classroom outcomes through the lens of the NRC's conceptual framework and the NGSS. The self-study employed design-based research (DBR) methods to investigate what happened in my secondary classroom when I designed, enacted, and reflected on units of study for my science, engineering, and mathematics classes. I utilized various best practices including Learning for Use (LfU) and Understanding by Design (UbD) models for instructional design, talk moves as a tool for promoting discourse, and modeling instruction for these designed units of study. The DBR strategy was chosen to promote reflective cycles, which are consistent with and in support of the self-study framework. A multiple case, mixed-methods approach was used for data collection and analysis. The findings in the study are reported by study phase in terms of unit planning, unit enactment, and unit reflection. The findings have implications for science teaching, teacher professional development, and teacher education.

Data Publishing Services in a Scientific Project Platform

Science.gov (United States)

Schroeder, Matthias; Stender, Vivien; Wächter, Joachim

2014-05-01

Data-intensive science lives from data. More and more interdisciplinary projects are aligned to mutually gain access to their data, models and results. In order to achieving this, an umbrella project GLUES is established in the context of the "Sustainable Land Management" (LAMA) initiative funded by the German Federal Ministry of Education and Research (BMBF). The GLUES (Global Assessment of Land Use Dynamics, Greenhouse Gas Emissions and Ecosystem Services) project supports several different regional projects of the LAMA initiative: Within the framework of GLUES a Spatial Data Infrastructure (SDI) is implemented to facilitate publishing, sharing and maintenance of distributed global and regional scientific data sets as well as model results. The GLUES SDI supports several OGC webservices like the Catalog Service Web (CSW) which enables it to harvest data from varying regional projects. One of these regional projects is SuMaRiO (Sustainable Management of River Oases along the Tarim River) which aims to support oasis management along the Tarim River (PR China) under conditions of climatic and societal changes. SuMaRiO itself is an interdisciplinary and spatially distributed project. Working groups from twelve German institutes and universities are collecting data and driving their research in disciplines like Hydrology, Remote Sensing, and Agricultural Sciences among others. Each working group is dependent on the results of another working group. Due to the spatial distribution of participating institutes the data distribution is solved by using the eSciDoc infrastructure at the German Research Centre for Geosciences (GFZ). Further, the metadata based data exchange platform PanMetaDocs will be used by participants collaborative. PanMetaDocs supports an OAI-PMH interface which enables an Open Source metadata portal like GeoNetwork to harvest the information. The data added in PanMetaDocs can be labeled with a DOI (Digital Object Identifier) to publish the data and to

An architectural framework for developing intelligent applications for the carbon dioxide capture process

Energy Technology Data Exchange (ETDEWEB)

Luo, C.; Zhou, Q.; Chan, C.W. [Regina Univ., SK (Canada)

2009-07-01

This presentation reported on the development of automated application solutions for the carbon dioxide (CO{sub 2}) capture process. An architectural framework was presented for developing intelligent systems for the process system. The chemical absorption process consists of dozens of components. It therefore generates more than a hundred different types of data. Developing automated support for these tasks is desirable because the monitoring, analysis and diagnosis of the data is very complex. The proposed framework interacts with an implemented domain ontology for the CO{sub 2} capture process, which consists of information derived from senior operators of the CO{sub 2} pilot plant at the International Test Centre for Carbon Dioxide Capture at University of Regina. The well-defined library within the framework reduces development time and cost. The framework also has built-in web-based software components for data monitoring, management, and analysis. These components provide support for generating automated solutions for the CO{sub 2} capture process. An automated monitoring system that was also developed based on the architectural framework.

Patch layout generation by detecting feature networks

KAUST Repository

Cao, Yuanhao

2015-02-01

The patch layout of 3D surfaces reveals the high-level geometric and topological structures. In this paper, we study the patch layout computation by detecting and enclosing feature loops on surfaces. We present a hybrid framework which combines several key ingredients, including feature detection, feature filtering, feature curve extension, patch subdivision and boundary smoothing. Our framework is able to compute patch layouts through concave features as previous approaches, but also able to generate nice layouts through smoothing regions. We demonstrate the effectiveness of our framework by comparing with the state-of-the-art methods.

Model Oriented Application Generation for Industrial Control Systems

CERN Document Server

Copy, B; Blanco Vinuela, E; Fernandez Adiego, B; Nogueira Ferandes, R; Prieto Barreiro, I

2011-01-01

The CERN Unified Industrial Control Systems framework (UNICOS) is a software generation methodology and a collection of development tools that standardizes the design of industrial control applications [1]. A Software Factory, named the UNICOS Application Builder (UAB) [2], was introduced to ease extensibility and maintenance of the framework, introducing a stable metamodel, a set of platformindependent models and platformspecific configurations against which code generation plugins and configuration generation plugins can be written. Such plugins currently target PLC programming environments (Schneider and SIEMENS PLCs) as well as SIEMENS WinCC Open Architecture SCADA (previously known as ETM PVSS) but are being expanded to cover more and more aspects of process control systems. We present what constitutes the UNICOS metamodel and the models in use, how these models can be used to capture knowledge about industrial control systems and how this knowledge can be leveraged to generate both code and configuratio...

Money Laundering Detection Framework to Link the Disparate and Evolving Schemes

Directory of Open Access Journals (Sweden)

Murad Mehmet

2013-09-01

Full Text Available Money launderers hide traces of their transactions with the involvement of entities that participate in sophisticated schemes. Money laundering detection requires unraveling concealed connections among multiple but seemingly unrelated human money laundering networks, ties among actors of those schemes, and amounts of funds transferred among those entities. The link among small networks, either financial or social, is the primary factor that facilitates money laundering. Hence, the analysis of relations among money laundering networks is required to present the full structure of complex schemes. We propose a framework that uses sequence matching, case-based analysis, social network analysis, and complex event processing to detect money laundering. Our framework captures an ongoing single scheme as an event, and associations among such ongoing sequence of events to capture complex relationships among evolving money laundering schemes. The framework can detect associated multiple money laundering networks even in the absence of some evidence. We validated the accuracy of detecting evolving money laundering schemes using a multi-phases test methodology. Our test used data generated from real-life cases, and extrapolated to generate more data from real-life schemes generator that we implemented.

A Theoretical Framework for Studying Adolescent Contraceptive Use.

Science.gov (United States)

Urberg, Kathryn A.

1982-01-01

Presents a theoretical framework for viewing adolescent contraceptive usage. The problem-solving process is used for developmentally examining the competencies that must be present for effective contraceptive use, including: problem recognition, motivation, generation of alternatives, decision making and implementation. Each aspect is discussed…

featsel: A framework for benchmarking of feature selection algorithms and cost functions

OpenAIRE

Marcelo S. Reis; Gustavo Estrela; Carlos Eduardo Ferreira; Junior Barrera

2017-01-01

In this paper, we introduce featsel, a framework for benchmarking of feature selection algorithms and cost functions. This framework allows the user to deal with the search space as a Boolean lattice and has its core coded in C++ for computational efficiency purposes. Moreover, featsel includes Perl scripts to add new algorithms and/or cost functions, generate random instances, plot graphs and organize results into tables. Besides, this framework already comes with dozens of algorithms and co...

Real-Time Optimization and Control of Next-Generation Distribution

Science.gov (United States)

-Generation Distribution Infrastructure Real-Time Optimization and Control of Next-Generation Distribution developing a system-theoretic distribution network management framework that unifies real-time voltage and Infrastructure | Grid Modernization | NREL Real-Time Optimization and Control of Next

Anastomose do nervo facial de coelhos com cola de fibrina: estudo da velocidade de condução nervosa Rabbit facial nerve anastomosis with fibrin glue: nerve conduction velocity evaluation

Directory of Open Access Journals (Sweden)

Francisco Aurelio Lucchesi Sandrini

2007-04-01

Full Text Available OBJETIVO: Este estudo tem o objetivo de avaliar através da velocidade de condução nervosa com eletrodos de superfície a utilização da cola de fibrina na anastomose nervosa. MÉTODOS: Neste experimento, foram avaliadas as diferenças entre as velocidades de condução nervosa pré e pós-operatória do nervo facial esquerdo de 12 coelhos. Foi verificada a existência de correlação entre a velocidade de condução nervosa e o número de axônios regenerados no pós-operatório. Os nervos transeccionados foram unidos com cola de fibrina. O potencial de ação motora foi obtido com o uso de eletrodos de superfície. O eletrodo de estimulação foi colocado imediatamente à frente do pavilhão auditivo (tronco do nervo facial e o eletrodo de gravação foi colocado no músculo quadrado do lábio inferior. RESULTADOS: A média normal da velocidade de condução nervosa foi de 36,53 m/seg. Ao final do período, a velocidade de condução nervosa atingiu um valor de aproximadamente 81% do valor normal. Não foi observada correlação significativa entre a velocidade de condução nervosa pós-operatória e o número de axônios regenerados (p=0,146. CONCLUSÃO: A anastomose com cola de fibrina pode ser utilizada para anastomose nervosa no modelo animal e nervo estudados.AIM: The aim of this study was to evaluate the use of fibrin glue on nerve anastomosis, and study conduction velocity obtained by surface electrodes. METHODS: In this experimental model we evaluated nerve conduction velocity differences in the preoperative and postoperative periods, for the left facial nerve of 12 rabbits. Then, we evaluated whether there were correlations between conduction velocity and the number of postoperative regenerated axons. The sectioned nerves were anastomosed with fibrin glue. The muscle action potentials were obtained from surface electrodes. The stimulation electrode was placed immediately before the ear pinna (facial nerve trunk and the recording

MadGraph/MadEvent. The new web generation

International Nuclear Information System (INIS)

Alwall, J.

2007-01-01

The new web-based version of the automatized process and event generator MadGraph/MadEvent is now available. Recent developments are: New models, notably MSSM, 2HDM and a framework for addition of user-defined models, inclusive sample generation and on-line hadronization and detector simulation. Event generation can be done on-line on any of our clusters. (author)

Systematic Optimization-Based Integrated Chemical Product–Process Design Framework

DEFF Research Database (Denmark)

Cignitti, Stefano; Mansouri, Seyed Soheil; Woodley, John M.

2018-01-01

An integrated optimization-based framework for product and process design is proposed. The framework uses a set of methods and tools to obtain the optimal product–process design solution given a set of economic and environmental sustainability targets. The methods and tools required are property...... of the framework is demonstrated through three case studies: (i) refrigeration cycle unit for R134a replacement, (ii) a mixed working fluid design problem for R134a replacement, and (iii) pure solvent design for water-acetic acid LLE extraction. Through the application of the framework it is demonstrated that all...... prediction through group contributions, unless supported with a database, computer-aided molecular and mixture/blend design for generation of novel as well as existing products and mathematical programming for formulating and solving multiscale integrated process–product design problems. The application...

The OME Framework for genome-scale systems biology

Energy Technology Data Exchange (ETDEWEB)

Palsson, Bernhard O. [Univ. of California, San Diego, CA (United States); Ebrahim, Ali [Univ. of California, San Diego, CA (United States); Federowicz, Steve [Univ. of California, San Diego, CA (United States)

2014-12-19

The life sciences are undergoing continuous and accelerating integration with computational and engineering sciences. The biology that many in the field have been trained on may be hardly recognizable in ten to twenty years. One of the major drivers for this transformation is the blistering pace of advancements in DNA sequencing and synthesis. These advances have resulted in unprecedented amounts of new data, information, and knowledge. Many software tools have been developed to deal with aspects of this transformation and each is sorely needed [1-3]. However, few of these tools have been forced to deal with the full complexity of genome-scale models along with high throughput genome- scale data. This particular situation represents a unique challenge, as it is simultaneously necessary to deal with the vast breadth of genome-scale models and the dizzying depth of high-throughput datasets. It has been observed time and again that as the pace of data generation continues to accelerate, the pace of analysis significantly lags behind [4]. It is also evident that, given the plethora of databases and software efforts [5-12], it is still a significant challenge to work with genome-scale metabolic models, let alone next-generation whole cell models [13-15]. We work at the forefront of model creation and systems scale data generation [16-18]. The OME Framework was borne out of a practical need to enable genome-scale modeling and data analysis under a unified framework to drive the next generation of genome-scale biological models. Here we present the OME Framework. It exists as a set of Python classes. However, we want to emphasize the importance of the underlying design as an addition to the discussions on specifications of a digital cell. A great deal of work and valuable progress has been made by a number of communities [13, 19-24] towards interchange formats and implementations designed to achieve similar goals. While many software tools exist for handling genome

Independent life history evolution between generations of bivoltine species: a case study of cyclical parthenogenesis.

Science.gov (United States)

Hood, Glen R; Ott, James R

2017-04-01

Successive generations of bi- and multivoltine species encounter differing biotic and abiotic environments intra-annually. The question of whether selection can independently adjust the relationship between body size and components of reproductive effort within successive generations in response to generation-specific environmental variation is applicable to a diversity of taxa. Herein, we develop a conceptual framework that illustrates increasingly independent life history adjustments between successive generations of taxa exhibiting complex life cycles. We apply this framework to the reproductive biology of the gall-forming insect, Belonocnema treatae (Hymenoptera: Cynipidae). This bivoltine species expresses cyclical parthenogenesis in which alternating sexual and asexual generations develop in different seasons and different environments. We tested the hypotheses that ecological divergence between the alternate generations is accompanied by generational differences in body size, egg size, and egg number and by changes in the relationships between body size and these components of reproductive effort. Increased potential reproductive effort of sexual generation B. treatae is attained by increased body size and egg number (with no trade-off between egg number and egg size) and by a significant increase in the slope of the relationship between body size and potential fecundity. These generation-specific relationships, interpreted in the context of the model framework, suggest that within each generation selection has independently molded the relationships relating body size to potential fecundity and potential reproductive effort in B. treatae. The conceptual framework is broadly applicable to comparisons involving the alternating generations of bi- and multivoltine species.

Treatment of non-healing sternum wound after open-heart surgery with allogenic platelet-rich plasma and fibrin glue-preliminary outcomes

Directory of Open Access Journals (Sweden)

Mohammad Abbasi Tashnizi

2013-01-01

Full Text Available Introduction: Non-healing wound in the sternal region after coronary arteries bypass graft surgery is a serious complication. For healing a chronic wound, several novel approaches have been proposed recently such as using bone marrow stem cells, platelets and fibrin glue (PFG; but a non-invasive method is highly desirable in the first approach for treatment. The current study was undertaken to evaluate the effect of the combination of PFG in one treatment. Materials and Methods: We report on the treatment of six patients with life-threatening chronic sternum wounds, which caused septicemia with multi-drug resistant pathogens. The ulcers were extensively debrided initially and were measured and photographed at weekly intervals. The combination of PFG was applied topically on the wound after every 2 days. Results: The wounds were completely closed in five patients and significantly reduced in size in one. There was no evidence of local or systemic complications and any abnormal tissue formation, keloid or hypertrophic scarring. Conclusions: Our study suggests, in the first approach, PFG can be used safely in order to heal a non healing sternum wound following coronary artery bypass surgery.

Model oriented application generation for industrial control systems

International Nuclear Information System (INIS)

Copy, B.; Barillere, R.; Blanco, E.; Fernandez Adiego, B.; Nogueira Fernandes, R.; Prieto Barreiro, I.

2012-01-01

The CERN Unified Industrial Control Systems framework (UNICOS) is a software generation methodology and a collection of development tools that standardizes the design of industrial control applications. A Software Factory, named the UNICOS Application Builder (UAB), was introduced to ease extensibility and maintenance of the framework, introducing a stable meta-model, a set of platform-independent models and platform-specific configurations against which code generation plug-ins and configuration generation plug-ins can be written. Such plug-ins currently target PLC programming environments (Schneider and SIEMENS PLCs) as well as SIEMENS WinCC Open Architecture SCADA (previously known as ETM PVSS) but are being expanded to cover more and more aspects of process control systems. We present what constitutes the UNICOS meta-model and the models in use, how these models can be used to capture knowledge about industrial control systems and how this knowledge can be used to generate both code and configuration for a variety of target usages. (authors)

Generating unit maintenance scheduling under competitive market environments

International Nuclear Information System (INIS)

Jin Ho Kim; Jong Bae Park; Jong Keun Park; Yeung Han Chun

2005-01-01

A novel approach to a generating unit maintenance scheduling problem in competitive electricity markets is presented in this paper. The objective is to develop a game-theoretic framework for analyzing strategic behaviors of generating companies (Gencos) from the standpoint of the generating unit maintenance scheduling (GMS) game and for obtaining the equilibrium solution for the GMS game. The GMS problem is formulated as a dynamic non-cooperative game with complete information. The players correspond to profit maximizing individual Gencos, and the payoff of each player is defined as the profits from the energy market. The optimal schedule is defined by Nash equilibrium (equilibriums) of the game. Numerical results for two-Genco system are used to demonstrate that the proposed framework can be successfully applied to analyzing the strategic behaviors of each Genco and to obtaining the corresponding Nash equilibrium. The result indicates that generating unit maintenance schedule is one of the major strategic behaviors whereby Genco maximize their profits in a competitive market environment. (author)

Recycling, reducing and reusing: A theoretical framework

International Nuclear Information System (INIS)

Kubursi, A.A.; Butterfield, D.W.

1990-01-01

Macroeconomic models are generally based on a particular national income accounting framework. The current approach treats waste and pollution generation in such a way that any increase in these activities increases directly the gross domestic product of the economy. A reformulation is suggested for the accounting framework so as to treat waste management and pollution abatement as services to business whose costs should be charged against business revenue. Even such costs to households may be considered as costs to output. In this way such expenses appear as a cost to society and not as a final output. A new theoretical framework is developed to correspond to the reformulated accounting principle that allows clear identification of recycling activity and waste management. The rectangular input-output framework is particularly suited for this treatment as it allows different industries to produce the same output and identifies different commodities as inputs in the production of the same output. With the new framework, it is possible to examine the socioeconomic consequences of increased use and production of recyclables. Equally important is the ability to assess the relative efficiency of alternative policies to reuse or reduce the use of products and resources through price incentives and full cost charges. 2 tabs

Metamodel of the IT Governance Framework COBIT

Directory of Open Access Journals (Sweden)

João Souza Neto

2013-10-01

Full Text Available This paper addresses the generation and analysis of the COBIT 4.1 ontological metamodel of IT Governance framework. The ontological metamodels represent the logical structures and fundamental semantics of framework models and constitute adequate tools for the analysis, adaptation, comparison and integration of IT best practice frameworks. The MetaFrame methodology used for the construction of the COBIT metamodel is based on the discipline of conceptual metamodeling and on the extended Entity/Relationship methodology. It has an iterative process of construction of the metamodel’s components, using techniques of modeling and documentation of information systems. In the COBIT 4.1metamodel, the central entity type is the IT Process. The entity type of IT Domain represents the four domains that group one or more IT processes of the COBIT 4.1. In turn, these domains are divided into one or more Activities that are carried through by one or more Roles which are consulted, informed, accounted for or liable for each Activity. The COBIT 4.1 metamodel may suggest adaptation or implementation of a new process within the framework or even contribute to the integration of frameworks, when, after the processes of analysis and comparison, there are connection points between the components and the logical structures of its relationships.

Custom pulse generator for RPC testing

International Nuclear Information System (INIS)

Gil, A.; Castro, E.; Diaz, J.; Fonte, P.; Garzon, J.A.; Montes, N.; Zapata, M.

2009-01-01

We present a pulse generator able to generate pulses statistically similar to the ones produced by RPC cells. The device generates up to four arrays of fast and narrow random-like pulses. Polarity, maximum amplitudes, widths and pulse rate in each channel may be modified independently in order to simulate different RPC setups and environments. This portable and cost-effective pulse generator is a versatile instrument for testing FE-Electronics and different real detector features related with the signal propagation inside the detector. It has been developed in the framework of the ESTRELA project of the HADES experiment at GSI.

Development of Softcore Processor based RTU for FBR

International Nuclear Information System (INIS)

Gour, Aditya; Santhana Raj, A.; Behera, R.P.; Murali, N.; Swaminathan, P.

2010-01-01

Remote Terminal Units (RTU) are used to acquire analog/digital signals and generate potential free contact outputs and send the acquired data through LAN. The aim of this design is to develop a Soft-Core Processor based RTU by implementing the glue logic along with 8051 microcontroller present in existing RTUs into a single FPGA, so that component count and power consumption on the board will be reduced and thereby achieving a higher reliability than before. Implementation of glue logic was done using VHDL and Altium's TSK51 Softcore was used in place of 8051 microcontroller. (author)

GENERATION OF IRREGULAR HEXAGONAL MESHES

Directory of Open Access Journals (Sweden)

Vlasov Aleksandr Nikolaevich

2012-07-01

Decomposition is performed in a constructive way and, as option, it involves meshless representation. Further, this mapping method is used to generate the calculation mesh. In this paper, the authors analyze different cases of mapping onto simply connected and bi-connected canonical domains. They represent forward and backward mapping techniques. Their potential application for generation of nonuniform meshes within the framework of the asymptotic homogenization theory is also performed to assess and project effective characteristics of heterogeneous materials (composites.

Fixação de enxerto cutâneo em malha de espessura total com sutura ou cola de fibrina Fixation of full-thickness mesh skin using suture or fibrin glue

Directory of Open Access Journals (Sweden)

M.S.P. Amaral

2004-06-01

Full Text Available Avaliou-se a influência da cola de fibrina, derivada do veneno de serpente, na fixação e integração de enxerto de pele. Foram utilizados nove cães, sem raça definida, com peso médio de 15kg. Foi induzida ferida de 4×4cm de área, na face crânio-proximal dos antebraços direito e esquerdo. Um enxerto de espessura total foi colhido da região torácica e expandido por meio de expansor de pele. No membro direito o enxerto foi estabilizado no leito receptor por meio de pontos isolados simples; no esquerdo foi fixado pela aplicação de cola de fibrina e oito pontos de sutura. O sítio doador foi fechado empregando-se retalho cutâneo bipediculado. As bandagens do leito receptor foram oclusivas e não aderentes e aplicou-se pomada de neomicina com bacitracina. A troca de bandagens ocorreu diariamente até o sétimo dia de pós-operatório e, posteriormente, a cada três dias. A área de sobrevivência do enxerto foi obtida pela subtração das áreas não viáveis e total medidas com fotomicroscópio Nikon conectado a um sistema de análise de imagem KS-300 aos três, sete, 15 e 30 dias de pós-operatório. Para a avaliação microscópica, a área do enxerto foi colhida em três animais aos sete, 15 e 30 dias de pós-operatório. Não houve diferença entre momentos de avaliação e técnicas de fixação quanto à área de enxerto viável. Os enxertos fixados com cola apresentaram estágio de reparação mais avançado em todos os momentos. Concluiu-se que a cola de fibrina derivada do veneno de serpente tem moderado poder adesivo e, pela análise microscópica, favorece a integração do enxerto cutâneo em malha de espessura total.The purpose of this study was to evaluate the efficiency of fibrin glue, derived from snake venom, on fixation and integration of skin graft. Nine crossbred dogs, with average weight of 15kg were used. Wounds measuring 4×4 cm were induced at the cranioproximal aspect of the right and left forelimb. Full

Reframing Teach for America: A Conceptual Framework for the Next Generation of Scholarship

Science.gov (United States)

Scott, Janelle; Trujillo, Tina; Rivera, Marialena D.

2016-01-01

In this article, we advance a conceptual framework for the study of Teach For America (TFA) as a political and social movement with implicit and explicit ideological and political underpinnings. We argue that the second branch of TFA's mission statement, which maintains that TFA's greatest point of influence in public education is not in…

Runtime Detection Framework for Android Malware

Directory of Open Access Journals (Sweden)

TaeGuen Kim

2018-01-01

Full Text Available As the number of Android malware has been increased rapidly over the years, various malware detection methods have been proposed so far. Existing methods can be classified into two categories: static analysis-based methods and dynamic analysis-based methods. Both approaches have some limitations: static analysis-based methods are relatively easy to be avoided through transformation techniques such as junk instruction insertions, code reordering, and so on. However, dynamic analysis-based methods also have some limitations that analysis overheads are relatively high and kernel modification might be required to extract dynamic features. In this paper, we propose a dynamic analysis framework for Android malware detection that overcomes the aforementioned shortcomings. The framework uses a suffix tree that contains API (Application Programming Interface subtraces and their probabilistic confidence values that are generated using HMMs (Hidden Markov Model to reduce the malware detection overhead, and we designed the framework with the client-server architecture since the suffix tree is infeasible to be deployed in mobile devices. In addition, an application rewriting technique is used to trace API invocations without any modifications in the Android kernel. In our experiments, we measured the detection accuracy and the computational overheads to evaluate its effectiveness and efficiency of the proposed framework.

Efficacy of multifunnel traps for capturing emerald ash borer (Coleoptera: Buprestidae): effect of color, glue, and other trap coatings.

Science.gov (United States)

Francese, Joseph A; Fraser, Ivich; Lance, David R; Mastro, Victor C

2011-06-01

Tens of thousands of adhesive-coated purple prism traps are deployed annually in the United States to survey for the invasive emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae). A reusable, more user-friendly trap is desired by program managers, surveyors, and researchers. Field assays were conducted in southeastern Michigan to ascertain the feasibility of using nonsticky traps as survey and detection tools for emerald ash borer. Three nonsticky trap designs, including multifunnel (Lindgren), modified intercept panel, and drainpipe (all painted purple) were compared with the standard purple prism trap; no statistical differences in capture of emerald ash borer adults were detected between the multifunnel design and the prism. In subsequent color comparison assays, both green- and purple-painted multifunnel traps (and later, plastic versions of these colors) performed as well or better than the prism traps. Multifunnel traps coated with spray-on adhesive caught more beetles than untreated traps. The increased catch, however, occurred in the traps' collection cups and not on the trap surface. In a separate assay, there was no significant difference detected between glue-coated traps and Rain-X (normally a glass treatment)-coated traps, but both caught significantly more A. planipennis adults than untreated traps.

The GENIE Neutrino Monte Carlo Generator: Physics and User Manual

Energy Technology Data Exchange (ETDEWEB)

Andreopoulos, Costas [Univ. of Liverpool (United Kingdom). Dept. of Physics; Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL). Particle Physics Dept.; Barry, Christopher [Univ. of Liverpool (United Kingdom). Dept. of Physics; Dytman, Steve [Univ. of Pittsburgh, PA (United States). Dept. of Physics and Astronomy; Gallagher, Hugh [Tufts Univ., Medford, MA (United States). Dept. of Physics and Astronomy; Golan, Tomasz [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Univ. of Rochester, NY (United States). Dept. of Physics and Astronomy; Hatcher, Robert [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Perdue, Gabriel [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Yarba, Julia [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

2015-10-20

GENIE is a suite of products for the experimental neutrino physics community. This suite includes i) a modern software framework for implementing neutrino event generators, a state-of-the-art comprehensive physics model and tools to support neutrino interaction simulation for realistic experimental setups (the Generator product), ii) extensive archives of neutrino, charged-lepton and hadron scattering data and software to produce a comprehensive set of data/MC comparisons (the Comparisons product), and iii) a generator tuning framework and fitting applications (the Tuning product). This book provides the definite guide for the GENIE Generator: It presents the software architecture and a detailed description of its physics model and official tunes. In addition, it provides a rich set of data/MC comparisons that characterise the physics performance of GENIE. Detailed step-by-step instructions on how to install and configure the Generator, run its applications and analyze its outputs are also included.

Performance testing of real-time AI systems using the activation framework

International Nuclear Information System (INIS)

Becker, L.; Duckworth, J.; Laznovsky, A.; Green, P.

1992-01-01

This paper describes methods for automated performance testing of real-time artificial intelligence systems using the Activation Framework software development tool. The Activation Framework is suitable for applications such as the diagnosis of power system failures, which require the interpretation of large volumes of data in real-time. The Activation Framework consists of tools for compiling groups of Expert Systems rules into executable code modules, for automatically generating code modules from high level system configuration descriptions, and for automatically generating command files for program compilation and linking. It includes an operating system environment which provides the code which is common from one real-time AI applications to the next. It also includes mechanisms, described here, for automatic performance testing. The principal emphasis of this paper is on a rule based language which is used to capture performance specifications. This specification is compiled into code modules which are used to automatically test the system. This testing can validate that the system meets performance requirements during development and after maintenance. A large number of tests can be randomly generated and executed and the correctness of the outputs automatically validated. The paper also describes graph directed testing methods to minimize the number of test runs required

A framework for the evaluation of new interventional procedures.

Science.gov (United States)

Lourenco, Tania; Grant, Adrian M; Burr, Jennifer M; Vale, Luke

2012-03-01

The introduction of new interventional procedures is less regulated than for other health technologies such as pharmaceuticals. Decisions are often taken on evidence of efficacy and short-term safety from small-scale usually observational studies. This reflects the particular challenges of evaluating interventional procedures - the extra facets of skill and training and the difficulty defining a 'new' technology. Currently, there is no framework to evaluate new interventional procedures before they become available in clinical practice as opposed to new pharmaceuticals. This paper proposes a framework to guide the evaluation of a new interventional procedure. A framework was developed consisting of a four-stage progressive evaluation for a new interventional procedure: Stage 1: Development; Stage 2: Efficacy and short-term safety; Stage 3: Effectiveness and cost-effectiveness; and Stage 4: Implementation. The framework also suggests the types of studies or data collection methods that can be used to satisfy each stage. This paper makes a first step on a framework for generating evidence on new interventional procedures. The difficulties and limitations of applying such a framework are discussed. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Crystal water as the mol-ecular glue for obtaining different co-crystal ratios: the case of gallic acid tris-caffeine hexa-hydrate.

Science.gov (United States)

Vella-Zarb, L; Baisch, U

2018-04-01

The crystal structure of the hexa-hydrate co-crystal of gallic acid and caffeine, C 7 H 6 O 5 ·3C 8 H 10 N 4 O 2 ·6H 2 O or GAL3CAF·6H 2 O , is a remarkable example of the importance of hydrate water acting as structural glue to facilitate the crystallization of two components of different stoichiometries and thus to compensate an imbalance of hydrogen-bond donors and acceptors. The water mol-ecules provide the additional hydrogen bonds required to form a crystalline solid. Whereas the majority of hydrogen bonds forming the inter-molecular network between gallic acid and caffeine are formed by crystal water, only one direct classical hydrogen bond between two mol-ecules is formed between the carb-oxy-lic oxygen of gallic acid and the carbonyl oxygen of caffeine with d ( D ⋯ A ) = 2.672 (2) Å. All other hydrogen bonds either involve crystal water or utilize protonated carbon atoms as donors.

Toward a New Paradigm: Governance in a Broader Framework.

Science.gov (United States)

Deegan, William L.

1985-01-01

Argues that the issues and trends of the past decade make it necessary to reconsider governance processes and the way substantive issues are generated. Reviews major models for governance and proposes a broader, more integrated framework for analyzing governance issues. (DMM)

A framework to enhance security of physically unclonable functions using chaotic circuits

Science.gov (United States)

Chen, Lanxiang

2018-05-01

As a new technique for authentication and key generation, physically unclonable function (PUF) has attracted considerable attentions, with extensive research results achieved already. To resist the popular machine learning modeling attacks, a framework to enhance the security of PUFs is proposed. The basic idea is to combine PUFs with a chaotic system of which the response is highly sensitive to initial conditions. For this framework, a specific construction which combines the common arbiter PUF circuit, a converter, and the Chua's circuit is given to implement a more secure PUF. Simulation experiments are presented to further validate the framework. Finally, some practical suggestions for the framework and specific construction are also discussed.

A Comparative Evaluation of Procedural Level Generators in the Mario AI Framework

DEFF Research Database (Denmark)

Horn, Britton; Dahlskog, Steve; Shaker, Noor

dierent from another in terms of its output. To remedy this, we have conducted a large-scale comparative evaluation of level generators for the Mario AI Benchmark, a research-friendly clone of the classic platform game Super Mario Bros. In all, we compare the output of seven dierent level generators from...

Ecologically Sound Procedural Generation of Natural Environments

Directory of Open Access Journals (Sweden)

Benny Onrust

2017-01-01

Full Text Available Current techniques for the creation and exploration of virtual worlds are largely unable to generate sound natural environments from ecological data and to provide interactive web-based visualizations of such detailed environments. We tackle this challenge and propose a novel framework that (i explores the advantages of landscape maps and ecological statistical data, translating them to an ecologically sound plant distribution, and (ii creates a visually convincing 3D representation of the natural environment suitable for its interactive visualization over the web. Our vegetation model improves techniques from procedural ecosystem generation and neutral landscape modeling. It is able to generate diverse ecological sound plant distributions directly from landscape maps with statistical ecological data. Our visualization model integrates existing level of detail and illumination techniques to achieve interactive frame rates and improve realism. We validated with ecology experts the outcome of our framework using two case studies and concluded that it provides convincing interactive visualizations of large natural environments.

A Computational Framework for Bioimaging Simulation

Science.gov (United States)

Watabe, Masaki; Arjunan, Satya N. V.; Fukushima, Seiya; Iwamoto, Kazunari; Kozuka, Jun; Matsuoka, Satomi; Shindo, Yuki; Ueda, Masahiro; Takahashi, Koichi

2015-01-01

Using bioimaging technology, biologists have attempted to identify and document analytical interpretations that underlie biological phenomena in biological cells. Theoretical biology aims at distilling those interpretations into knowledge in the mathematical form of biochemical reaction networks and understanding how higher level functions emerge from the combined action of biomolecules. However, there still remain formidable challenges in bridging the gap between bioimaging and mathematical modeling. Generally, measurements using fluorescence microscopy systems are influenced by systematic effects that arise from stochastic nature of biological cells, the imaging apparatus, and optical physics. Such systematic effects are always present in all bioimaging systems and hinder quantitative comparison between the cell model and bioimages. Computational tools for such a comparison are still unavailable. Thus, in this work, we present a computational framework for handling the parameters of the cell models and the optical physics governing bioimaging systems. Simulation using this framework can generate digital images of cell simulation results after accounting for the systematic effects. We then demonstrate that such a framework enables comparison at the level of photon-counting units. PMID:26147508

A Computational Framework for Bioimaging Simulation.

Science.gov (United States)

Watabe, Masaki; Arjunan, Satya N V; Fukushima, Seiya; Iwamoto, Kazunari; Kozuka, Jun; Matsuoka, Satomi; Shindo, Yuki; Ueda, Masahiro; Takahashi, Koichi

2015-01-01

Using bioimaging technology, biologists have attempted to identify and document analytical interpretations that underlie biological phenomena in biological cells. Theoretical biology aims at distilling those interpretations into knowledge in the mathematical form of biochemical reaction networks and understanding how higher level functions emerge from the combined action of biomolecules. However, there still remain formidable challenges in bridging the gap between bioimaging and mathematical modeling. Generally, measurements using fluorescence microscopy systems are influenced by systematic effects that arise from stochastic nature of biological cells, the imaging apparatus, and optical physics. Such systematic effects are always present in all bioimaging systems and hinder quantitative comparison between the cell model and bioimages. Computational tools for such a comparison are still unavailable. Thus, in this work, we present a computational framework for handling the parameters of the cell models and the optical physics governing bioimaging systems. Simulation using this framework can generate digital images of cell simulation results after accounting for the systematic effects. We then demonstrate that such a framework enables comparison at the level of photon-counting units.

A Computational Framework for Bioimaging Simulation.

Directory of Open Access Journals (Sweden)

Masaki Watabe

Full Text Available Using bioimaging technology, biologists have attempted to identify and document analytical interpretations that underlie biological phenomena in biological cells. Theoretical biology aims at distilling those interpretations into knowledge in the mathematical form of biochemical reaction networks and understanding how higher level functions emerge from the combined action of biomolecules. However, there still remain formidable challenges in bridging the gap between bioimaging and mathematical modeling. Generally, measurements using fluorescence microscopy systems are influenced by systematic effects that arise from stochastic nature of biological cells, the imaging apparatus, and optical physics. Such systematic effects are always present in all bioimaging systems and hinder quantitative comparison between the cell model and bioimages. Computational tools for such a comparison are still unavailable. Thus, in this work, we present a computational framework for handling the parameters of the cell models and the optical physics governing bioimaging systems. Simulation using this framework can generate digital images of cell simulation results after accounting for the systematic effects. We then demonstrate that such a framework enables comparison at the level of photon-counting units.

GeneratorSE: A Sizing Tool for Variable-Speed Wind Turbine Generators

Energy Technology Data Exchange (ETDEWEB)

Sethuraman, Latha [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Dykes, Katherine L [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2017-09-22

This report documents a set of analytical models employed by the optimization algorithms within the GeneratorSE framework. The initial values and boundary conditions employed for the generation of the various designs and initial estimates for basic design dimensions, masses, and efficiency for the four different models of generators are presented and compared with empirical data collected from previous studies and some existing commercial turbines. These models include designs applicable for variable-speed, high-torque application featuring direct-drive synchronous generators and low-torque application featuring induction generators. In all of the four models presented, the main focus of optimization is electromagnetic design with the exception of permanent-magnet and wire-wound synchronous generators, wherein the structural design is also optimized. Thermal design is accommodated in GeneratorSE as a secondary attribute by limiting the winding current densities to acceptable limits. A preliminary validation of electromagnetic design was carried out by comparing the optimized magnetic loading against those predicted by numerical simulation in FEMM4.2, a finite-element software for analyzing electromagnetic and thermal physics problems for electrical machines. For direct-drive synchronous generators, the analytical models for the structural design are validated by static structural analysis in ANSYS.

The legal framework for nuclear power stations in the Federal Republic of Germany

International Nuclear Information System (INIS)

Schmidt-Preuss, M.

2008-01-01

Within the range of the power generation the part of nuclear energy amounts 22 % in Germany in the year 2007. The author of the contribution under consideration describes the legal framework for nuclear power stations in the Federal Republic of Germany. The following aspects are described: (a) The atomic law and the completion of the power generation from nuclear energy; (b) The disposal of nuclear wastes; (c) The Euratom contract; (d) The institutional framework for the execution of the atomic energy law; (e) Legal protection opposite atom legal sovereignty documents; (f) future of the atomic law; (g) European Union-Russian partnership agreement and cooperation agreement. In order to guarantee a sustainable power supply for the production of goods and services in a national economy, also the legal framework for nuclear power stations in Germany must be realized

Handling of the Generation of Primary Events in Gauss, the LHCb Simulation Framework

CERN Multimedia

Corti, G; Brambach, T; Brook, N H; Gauvin, N; Harrison, K; Harrison, P; He, J; Ilten, P J; Jones, C R; Lieng, M H; Manca, G; Miglioranzi, S; Robbe, P; Vagnoni, V; Whitehead, M; Wishahi, J

2010-01-01

The LHCb simulation application, Gauss, consists of two independent phases, the generation of the primary event and the tracking of particles produced in the experimental setup. For the LHCb experimental program it is particularly important to model B meson decays: the EvtGen code developed in CLEO and BaBar has been chosen and customized for non coherent B production as occuring in pp collisions at the LHC. The initial proton-proton collision is provided by a different generator engine, currently Pythia 6 for massive production of signal and generic pp collisions events. Beam gas events, background events originating from proton halo, cosmics and calibration events for different detectors can be generated in addition to pp collisions. Different generator packages are available in the physics community or specifically developed in LHCb, and are used for the different purposes. Running conditions affecting the events generated such as the size of the luminous region, the number of collisions occuring in a bunc...

Generation of human and structural capital: lessons from knowledge management

OpenAIRE

Agndal, Henrik; Nilsson, Ulf

2006-01-01

Interorganizational and social relationships can be seen as part of the intellectual capital of a firm. Existing frameworks of intellectual capital, however, fail to address how relationships should be managed to generate more intellectual capital. Drawing on the interaction approach and the fields of intellectual capital and knowledge management, this paper develops a framework for managing relationships. The framework is illustrated with a case study. It is also noted that firms can improve...

A Simulation and Modeling Framework for Space Situational Awareness

International Nuclear Information System (INIS)

Olivier, S.S.

2008-01-01

This paper describes the development and initial demonstration of a new, integrated modeling and simulation framework, encompassing the space situational awareness enterprise, for quantitatively assessing the benefit of specific sensor systems, technologies and data analysis techniques. The framework is based on a flexible, scalable architecture to enable efficient, physics-based simulation of the current SSA enterprise, and to accommodate future advancements in SSA systems. In particular, the code is designed to take advantage of massively parallel computer systems available, for example, at Lawrence Livermore National Laboratory. The details of the modeling and simulation framework are described, including hydrodynamic models of satellite intercept and debris generation, orbital propagation algorithms, radar cross section calculations, optical brightness calculations, generic radar system models, generic optical system models, specific Space Surveillance Network models, object detection algorithms, orbit determination algorithms, and visualization tools. The use of this integrated simulation and modeling framework on a specific scenario involving space debris is demonstrated

A Learning Activity Design Framework for Supporting Mobile Learning

Directory of Open Access Journals (Sweden)

Jalal Nouri

2016-01-01

Full Text Available This article introduces the Learning Activity Design (LEAD framework for the development and implementation of mobile learning activities in primary schools. The LEAD framework draws on methodological perspectives suggested by design-based research and interaction design in the specific field of technology-enhanced learning (TEL. The LEAD framework is grounded in four design projects conducted over a period of six years. It contributes a new understanding of the intricacies and multifaceted aspects of the design-process characterizing the development and implementation of mobile devices (i.e. smart phones and tablets in curricular activities conducted in Swedish primary schools. This framework is intended to provide both designers and researchers with methodological tools that take account of the pedagogical foundations of technologically-based educational interventions, usability issues related to the interaction with the mobile application developed, multiple data streams generated during the design project, multiple stakeholders involved in the design process and sustainability aspects of the mobile learning activities implemented in the school classroom.

An Empirical Generative Framework for Computational Modeling of Language Acquisition

Science.gov (United States)

Waterfall, Heidi R.; Sandbank, Ben; Onnis, Luca; Edelman, Shimon

2010-01-01

This paper reports progress in developing a computer model of language acquisition in the form of (1) a generative grammar that is (2) algorithmically learnable from realistic corpus data, (3) viable in its large-scale quantitative performance and (4) psychologically real. First, we describe new algorithmic methods for unsupervised learning of…

An Open Source Extensible Smart Energy Framework

Energy Technology Data Exchange (ETDEWEB)

Rankin, Linda [V-Squared, Portland, OR (United States)

2017-03-23

Aggregated distributed energy resources are the subject of much interest in the energy industry and are expected to play an important role in meeting our future energy needs by changing how we use, distribute and generate electricity. This energy future includes an increased amount of energy from renewable resources, load management techniques to improve resiliency and reliability, and distributed energy storage and generation capabilities that can be managed to meet the needs of the grid as well as individual customers. These energy assets are commonly referred to as Distributed Energy Resources (DER). DERs rely on a means to communicate information between an energy provider and multitudes of devices. Today DER control systems are typically vendor-specific, using custom hardware and software solutions. As a result, customers are locked into communication transport protocols, applications, tools, and data formats. Today’s systems are often difficult to extend to meet new application requirements, resulting in stranded assets when business requirements or energy management models evolve. By partnering with industry advisors and researchers, an implementation DER research platform was developed called the Smart Energy Framework (SEF). The hypothesis of this research was that an open source Internet of Things (IoT) framework could play a role in creating a commodity-based eco-system for DER assets that would reduce costs and provide interoperable products. SEF is based on the AllJoynTM IoT open source framework. The demonstration system incorporated DER assets, specifically batteries and smart water heaters. To verify the behavior of the distributed system, models of water heaters and batteries were also developed. An IoT interface for communicating between the assets and a control server was defined. This interface supports a series of “events” and telemetry reporting, similar to those defined by current smart grid communication standards. The results of this

On Innovation, Instability, and Growth. A Review and an Interpretative Framework

OpenAIRE

Pammolli Fabio

2014-01-01

In this paper I refer to and summarize the main findings of the stochastic benchmark developed together with S. Buldyrev, M. Riccaboni, and H.E. Stanley to analyze business firms growth and corporate dynamics. The framework encompasses the Gibrat's Law of Proportionate Effect and the growth process originally described by Herbert A. Simon as particular instances. The framework generates testable propositions along four different dimensions: i) firm size distribution, ii) the distribution of f...

Nigel: A Systemic Grammar for Text Generation.

Science.gov (United States)

1983-02-01

presumed. Basic references on the systemic framework include [Berry 75, Berry 77, Halliday 76a, Halliday 76b, Hudson 76, Halliday 81, de Joia 80...Edinburgh, 1979. [do Joia 80] de Joia , A., and A. Stanton, Terms in Systemic Linguistics, Batsford Academic and Educational, Ltd., London, 1980. -’C...1 A Grammar for Text Generation- -The Challenge ................................. 1 *1.2 A Grammar for Text Generation--The Design

A multicriteria framework with voxel-dependent parameters for radiotherapy treatment plan optimization

International Nuclear Information System (INIS)

Zarepisheh, Masoud; Uribe-Sanchez, Andres F.; Li, Nan; Jia, Xun; Jiang, Steve B.

2014-01-01

Purpose: To establish a new mathematical framework for radiotherapy treatment optimization with voxel-dependent optimization parameters. Methods: In the treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for a set of the objective functions associated to the organs. Recent discoveries indicate that adjusting parameters associated with each voxel may lead to better plan quality. However, it is still unclear regarding the mathematical reasons behind it. Furthermore, questions about the objective function selection and parameter adjustment to assure Pareto optimality as well as the relationship between the optimal solutions obtained from the organ-based and voxel-based models remain unanswered. To answer these questions, the authors establish in this work a new mathematical framework equipped with two theorems. Results: The new framework clarifies the different consequences of adjusting organ-dependent and voxel-dependent parameters for the treatment plan optimization of radiation therapy, as well as the impact of using different objective functions on plan qualities and Pareto surfaces. The main discoveries are threefold: (1) While in the organ-based model the selection of the objective function has an impact on the quality of the optimized plans, this is no longer an issue for the voxel-based model since the Pareto surface is independent of the objective function selection and the entire Pareto surface could be generated as long as the objective function satisfies certain mathematical conditions; (2) All Pareto solutions generated by the organ-based model with different objective functions are parts of a unique Pareto surface generated by the voxel-based model with any appropriate objective function; (3) A much larger Pareto surface is explored by adjusting voxel-dependent parameters than by adjusting organ-dependent parameters, possibly

Institutional Governance Framework for Determining Carbon-related Accounting Practices: An Exploratory Study of Electricity Generating Companies in Malaysia

Science.gov (United States)

Alrazi, B.; Mat Husin, N.

2016-03-01

Electricity industry is the major contributor of the global carbon emissions which has been scientifically identified as the main cause of climate change. With the various initiatives being implemented at the international, national, and industry levels, companies in the electricity industry are currently facing immense pressure from various stakeholders to demonstrate their policies, initiatives, targets, and performance on climate change. Against this background, accounting system is argued to be able to be play important roles in combating climate change. Using institutional governance as the underlying framework, we have identified several governance mechanisms as the determining factors for companies to have a systematic accounting system related to carbon emissions. The factors include environmental management system certification, environmental organization, publication of stand-alone sustainability reports, the use of GRI guidelines, environmental strategic planning, governance quality, and participation in CDP surveys and emissions trading scheme. We explored this issue in the context of major electricity generating companies in Malaysia and found that except for certified environmental management system, the other governance mechanisms are still lacking. The findings suggest that companies in Malaysia, in particular, from the electricity industry are not well prepared in facing risks related to climate change.

Urban water sustainability: framework and application

Directory of Open Access Journals (Sweden)

Wu Yang

2016-12-01

Full Text Available Urban areas such as megacities (those with populations greater than 10 million are hotspots of global water use and thus face intense water management challenges. Urban areas are influenced by local interactions between human and natural systems and interact with distant systems through flows of water, food, energy, people, information, and capital. However, analyses of water sustainability and the management of water flows in urban areas are often fragmented. There is a strong need to apply integrated frameworks to systematically analyze urban water dynamics and factors that influence these dynamics. We apply the framework of telecoupling (socioeconomic and environmental interactions over distances to analyze urban water issues, using Beijing as a demonstration megacity. Beijing exemplifies the global water sustainability challenge for urban settings. Like many other cities, Beijing has experienced drastic reductions in quantity and quality of both surface water and groundwater over the past several decades; it relies on the import of real and virtual water from sending systems to meet its demand for clean water, and releases polluted water to other systems (spillover systems. The integrative framework we present demonstrates the importance of considering socioeconomic and environmental interactions across telecoupled human and natural systems, which include not only Beijing (the water-receiving system but also water-sending systems and spillover systems. This framework helps integrate important components of local and distant human-nature interactions and incorporates a wide range of local couplings and telecouplings that affect water dynamics, which in turn generate significant socioeconomic and environmental consequences, including feedback effects. The application of the framework to Beijing reveals many research gaps and management needs. We also provide a foundation to apply the telecoupling framework to better understand and manage water

A development framework for semantically interoperable health information systems.

Science.gov (United States)

Lopez, Diego M; Blobel, Bernd G M E

2009-02-01

Semantic interoperability is a basic challenge to be met for new generations of distributed, communicating and co-operating health information systems (HIS) enabling shared care and e-Health. Analysis, design, implementation and maintenance of such systems and intrinsic architectures have to follow a unified development methodology. The Generic Component Model (GCM) is used as a framework for modeling any system to evaluate and harmonize state of the art architecture development approaches and standards for health information systems as well as to derive a coherent architecture development framework for sustainable, semantically interoperable HIS and their components. The proposed methodology is based on the Rational Unified Process (RUP), taking advantage of its flexibility to be configured for integrating other architectural approaches such as Service-Oriented Architecture (SOA), Model-Driven Architecture (MDA), ISO 10746, and HL7 Development Framework (HDF). Existing architectural approaches have been analyzed, compared and finally harmonized towards an architecture development framework for advanced health information systems. Starting with the requirements for semantic interoperability derived from paradigm changes for health information systems, and supported in formal software process engineering methods, an appropriate development framework for semantically interoperable HIS has been provided. The usability of the framework has been exemplified in a public health scenario.

GSI Helmholz Centre for Heavy Ion Research - ALFA: Next generation concurrent framework for ALICE and FAIR experiments

CERN Multimedia

CERN. Geneva

2015-01-01

FAIR is a new, unique international accelerator facility for the research with antiprotons and ions. It is being built at the GSI Darmstadt in Hesse, Germany. The commonalities between the ALICE and FAIR experiments and their computing requirements led to the development of a common software framework in an experiment independent way; ALFA (ALICE-FAIR framework). ALFA is designed for high quality parallel data processing and reconstruction on heterogeneous computing systems. It provides a data transport layer and the capability to coordinate multiple data processing components. ALFA is a flexible, elastic system which balances reliability and ease of development with performance by using a message based multi-processing in addition to multi-threading. The framework allows for usage of heterogeneous computing architectures by offloading (portions of code are accelerated on the device) or natively (where the full program is executed on the device ).

A Solution Generator Algorithm for Decision Making based Automated Negotiation in the Construction Domain

Directory of Open Access Journals (Sweden)

Arazi Idrus

2017-12-01

Full Text Available In this paper, we present our work-in-progress of a proposed framework for automated negotiation in the construction domain. The proposed framework enables software agents to conduct negotiations and autonomously make value-based decisions. The framework consists of three main components which are, solution generator algorithm, negotiation algorithm, and conflict resolution algorithm. This paper extends the discussion on the solution generator algorithm that enables software agents to generate solutions and rank them from 1st to nth solution for the negotiation stage of the operation. The solution generator algorithm consists of three steps which are, review solutions, rank solutions, and form ranked solutions. For validation purpose, we present a scenario that utilizes the proposed algorithm to rank solutions. The validation shows that the algorithm is promising, however, it also highlights the conflict between different parties that needs further negotiation action.

Lime-based restoration paints: characterization and evaluation of formulations using a native species from the Amazon flora and PVA-based glue as additives

Directory of Open Access Journals (Sweden)

Mayra Martins Silva

Full Text Available Abstract Based on historic documents, two lime-based paint formulations were produced in laboratory in order to evaluate their basic characteristics as restoration materials for historic buildings with lime-based components. The paints were made basically with hydrated lime, clay, water and linseed (Linum usitatissimum L. oil, and one formulation had PVA (polyvinyl acetate-based glue as fixative, and the other one, Couma guianensis' latex. Each paint component was characterized by XRD and FTIR, and color and specular gloss measurements were performed on both paints. A preliminary assessment of the paints was conducted using the Pipe Method, the salt crystallization test, visual analysis for dustiness, and analysis of microbiological growth. The results showed that the laboratory-produced paints are theoretically and technologically compatible with lime-based coatings, however, their superficial performance can be improved to achieve greater durability. This study also brings to light local materials from the Amazon region that have great potential to be used and recognized as raw materials for paints and which could also be investigated for other uses.

Radiative generation of quark masses and mixing angles in the two Higgs doublet model

International Nuclear Information System (INIS)

Ibarra, Alejandro; Solaguren-Beascoa, Ana

2014-01-01

We present a framework to generate the quark mass hierarchies and mixing angles by extending the Standard Model with one extra Higgs doublet. The charm and strange quark masses are generated by small quantum effects, thus explaining the hierarchy between the second and third generation quark masses. All the mixing angles are also generated by small quantum effects: the Cabibbo angle is generated at zeroth order in perturbation theory, while the remaining off-diagonal entries of the Cabibbo–Kobayashi–Maskawa matrix are generated at first order, hence explaining the observed hierarchy |V ub |,|V cb |≪|V us |. The values of the radiatively generated parameters depend only logarithmically on the heavy Higgs mass, therefore this framework can be reconciled with the stringent limits on flavor violation by postulating a sufficiently large new physics scale

Alberta's electricity policy framework : competitive, reliable, sustainable

International Nuclear Information System (INIS)

2005-01-01

This paper described public policies in Alberta that are implemented to create an electric power industry that is competitive, reliable and sustainable. The success of Alberta's competitive electric market framework can be attributed to new investment in the industry along with new players participating in the electricity market. The Alberta Department of Energy is committed to a competitive wholesale market model and to competitively-priced electricity. The Alberta Energy and Utilities Board supports the development of Alberta's vast resource base and facilitates power generation development and support through transmission development and an interconnected transmission system. A wholesale market Policy Task Force was established in 2005 to review the progress in Alberta's electric market design and its competitive retail market. This paper outlines a policy framework which addresses design of the regulated rate option post July 1, 2006; short-term adequacy; and long-term adequacy. Other inter-related market issues were also discussed, such as operating reserves market, transmission services, interties, demand response, balancing pool assets, credit, market power mitigation, and wind generation. It is expected that the recommendations in this paper will be implemented as quickly as possible following amendments to regulations or ISO rules. tabs., figs.

Regulatory frameworks for decentralised energy

International Nuclear Information System (INIS)

Woodman, Bridget; Baker, Philip

2008-01-01

This paper considers aspects of the current regulatory frameworks for markets and infrastructure which can inhibit the deployment of decentralised energy. The government has stated that decentralised energy can make a positive contribution to reducing the UK's carbon emissions, but recognises that at the moment the technologies face market and regulatory barriers. If it is to become a viable alternative to centralised generation, energy market design and the regulation of energy infrastructure will have to evolve to ensure that decentralised options are no longer locked out. (author)

A General Symbolic PDE Solver Generator: Beyond Explicit Schemes

Directory of Open Access Journals (Sweden)

K. Sheshadri

2003-01-01

Full Text Available This paper presents an extension of our Mathematica- and MathCode-based symbolic-numeric framework for solving a variety of partial differential equation (PDE problems. The main features of our earlier work, which implemented explicit finite-difference schemes, include the ability to handle (1 arbitrary number of dependent variables, (2 arbitrary dimensionality, and (3 arbitrary geometry, as well as (4 developing finite-difference schemes to any desired order of approximation. In the present paper, extensions of this framework to implicit schemes and the method of lines are discussed. While C++ code is generated, using the MathCode system for the implicit method, Modelica code is generated for the method of lines. The latter provides a preliminary PDE support for the Modelica language. Examples illustrating the various aspects of the solver generator are presented.

The Event Coordination Notation: Execution Engine and Programming Framework

DEFF Research Database (Denmark)

Kindler, Ekkart

2012-01-01

that was written manually. In this paper, we rephrase the main concepts of ECNO. The focus of this paper, however, is on the architecture of the ECNO execution engine and its programming framework. We will show how this framework allows us to integrate ECNO with object-oriented models, how it works without any......ECNO (Event Coordination Notation) is a notation for modelling the behaviour of a software system on top of some object-oriented data model. ECNO has two main objectives: On the one hand, ECNO should allow modelling the behaviour of a system on the domain level; on the other hand, it should...... be possible to completely generate code from ECNO and the underlying object-oriented domain models. Today, there are several approaches that would allow to do this. But, most of them would require that the data models and the behaviour models are using the same technology and the code is generated together...

Harnessing the flexibility of thermostatic loads in microgrids with Solar Power Generation

NARCIS (Netherlands)

Morales González, R.; Shariat Torbaghan, S.; Gibescu, M.; Cobben, S.

2016-01-01

This paper presents a demand response (DR) framework that intertwines thermodynamic building models with a genetic algorithm (GA)-based optimization method. The framework optimizes heating/cooling schedules of end-users inside a business park microgrid with local distributed generation from

Large Ensemble Analytic Framework for Consequence-Driven Discovery of Climate Change Scenarios

Science.gov (United States)

Lamontagne, Jonathan R.; Reed, Patrick M.; Link, Robert; Calvin, Katherine V.; Clarke, Leon E.; Edmonds, James A.

2018-03-01

An analytic scenario generation framework is developed based on the idea that the same climate outcome can result from very different socioeconomic and policy drivers. The framework builds on the Scenario Matrix Framework's abstraction of "challenges to mitigation" and "challenges to adaptation" to facilitate the flexible discovery of diverse and consequential scenarios. We combine visual and statistical techniques for interrogating a large factorial data set of 33,750 scenarios generated using the Global Change Assessment Model. We demonstrate how the analytic framework can aid in identifying which scenario assumptions are most tied to user-specified measures for policy relevant outcomes of interest, specifically for our example high or low mitigation costs. We show that the current approach for selecting reference scenarios can miss policy relevant scenario narratives that often emerge as hybrids of optimistic and pessimistic scenario assumptions. We also show that the same scenario assumption can be associated with both high and low mitigation costs depending on the climate outcome of interest and the mitigation policy context. In the illustrative example, we show how agricultural productivity, population growth, and economic growth are most predictive of the level of mitigation costs. Formulating policy relevant scenarios of deeply and broadly uncertain futures benefits from large ensemble-based exploration of quantitative measures of consequences. To this end, we have contributed a large database of climate change futures that can support "bottom-up" scenario generation techniques that capture a broader array of consequences than those that emerge from limited sampling of a few reference scenarios.

Knowledge Generation as Natural Computation

Directory of Open Access Journals (Sweden)

Gordana Dodig-Crnkovic

2008-04-01

Full Text Available Knowledge generation can be naturalized by adopting computational model of cognition and evolutionary approach. In this framework knowledge is seen as a result of the structuring of input data (data ? information ? knowledge by an interactive computational process going on in the agent during the adaptive interplay with the environment, which clearly presents developmental advantage by increasing agent's ability to cope with the situation dynamics. This paper addresses the mechanism of knowledge generation, a process that may be modeled as natural computation in order to be better understood and improved.

Calculational framework for safety analyses of non-reactor nuclear facilities

International Nuclear Information System (INIS)

Coleman, J.R.

1994-01-01

A calculational framework for the consequences analysis of non-reactor nuclear facilities is presented. The analysis framework starts with accident scenarios which are developed through a traditional hazard analysis and continues with a probabilistic framework for the consequences analysis. The framework encourages the use of response continua derived from engineering judgment and traditional deterministic engineering analyses. The general approach consists of dividing the overall problem into a series of interrelated analysis cells and then devising Markov chain like probability transition matrices for each of the cells. An advantage of this division of the problem is that intermediate output (as probability state vectors) are generated at each calculational interface. The series of analyses when combined yield risk analysis output. The analysis approach is illustrated through application to two non-reactor nuclear analyses: the Ulysses Space Mission, and a hydrogen burn in the Hanford waste storage tanks

A framework for designing and improving learning environments fostering creativity

Directory of Open Access Journals (Sweden)

Norio Ishii