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Sample records for glue generation framework

  1. Glue Generation Framework in Uniframe for the CORBA-Java/RMI Interoperability

    National Research Council Canada - National Science Library

    Tammala, Kalpana

    2004-01-01

    .... The UniFrame approach provides a seamless framework for achieving a DCS by automatic or semi-automatic integration of heterogeneous distributed components white taking into account their QoS (Quality of Service...

  2. A direct biocombinatorial strategy toward next generation, mussel-glue inspired saltwater adhesives.

    Science.gov (United States)

    Wilke, Patrick; Helfricht, Nicolas; Mark, Andreas; Papastavrou, Georg; Faivre, Damien; Börner, Hans G

    2014-09-10

    Biological materials exhibit remarkable, purpose-adapted properties that provide a source of inspiration for designing new materials to meet the requirements of future applications. For instance, marine mussels are able to attach to a broad spectrum of hard surfaces under hostile conditions. Controlling wet-adhesion of synthetic macromolecules by analogue processes promises to strongly impact materials sciences by offering advanced coatings, adhesives, and glues. The de novo design of macromolecules to mimic complex aspects of mussel adhesion still constitutes a challenge. Phage display allows material scientists to design specifically interacting molecules with tailored affinity to material surfaces. Here, we report on the integration of enzymatic processing steps into phage display biopanning to expand the biocombinatorial procedure and enable the direct selection of enzymatically activable peptide adhesion domains. Adsorption isotherms and single molecule force spectroscopy show that those de novo peptides mimic complex aspects of bioadhesion, such as enzymatic activation (by tyrosinase), the switchability from weak to strong binders, and adsorption under hostile saltwater conditions. Furthermore, peptide-poly(ethylene oxide) conjugates are synthesized to generate protective coatings, which possess anti-fouling properties and suppress irreversible interactions with blood-plasma protein cocktails. The extended phage display procedure provides a generic way to non-natural peptide adhesion domains, which not only mimic nature but also improve biological sequence sections extractable from mussel-glue proteins. The de novo peptides manage to combine several tasks in a minimal 12-mer sequence and thus pave the way to overcome major challenges of technical wet glues.

  3. Second generation registry framework.

    Science.gov (United States)

    Bellgard, Matthew I; Render, Lee; Radochonski, Maciej; Hunter, Adam

    2014-01-01

    Information management systems are essential to capture data be it for public health and human disease, sustainable agriculture, or plant and animal biosecurity. In public health, the term patient registry is often used to describe information management systems that are used to record and track phenotypic data of patients. Appropriate design, implementation and deployment of patient registries enables rapid decision making and ongoing data mining ultimately leading to improved patient outcomes. A major bottleneck encountered is the static nature of these registries. That is, software developers are required to work with stakeholders to determine requirements, design the system, implement the required data fields and functionality for each patient registry. Additionally, software developer time is required for ongoing maintenance and customisation. It is desirable to deploy a sophisticated registry framework that can allow scientists and registry curators possessing standard computing skills to dynamically construct a complete patient registry from scratch and customise it for their specific needs with little or no need to engage a software developer at any stage. This paper introduces our second generation open source registry framework which builds on our previous rare disease registry framework (RDRF). This second generation RDRF is a new approach as it empowers registry administrators to construct one or more patient registries without software developer effort. New data elements for a diverse range of phenotypic and genotypic measurements can be defined at any time. Defined data elements can then be utilised in any of the created registries. Fine grained, multi-level user and workgroup access can be applied to each data element to ensure appropriate access and data privacy. We introduce the concept of derived data elements to assist the data element standards communities on how they might be best categorised. We introduce the second generation RDRF that

  4. Dialogue Coherence: A Generation Framework

    NARCIS (Netherlands)

    Beun, R.J.; Eijk, R.M. van

    2007-01-01

    This paper presents a framework for the generation of coherent elementary conversational sequences at the speech act level. We will embrace the notion of a cooperative dialogue game in which two players produce speech acts to transfer relevant information with respect to their commitments.

  5. Society, Land, Love or Money (A Strategic Model of How to Glue the Generations Together),

    Science.gov (United States)

    1981-01-01

    carrying of extra capital stock. 33 REFERENCES Dawkins , R. (1976), The Selfish Gene . New York: Oxford University Press. Dubey, P. and N. Shubik (1981...a gene would rapidly disappear. The care for offspring needs to be forthcoming until the last of the new generation is selfsufficient and able to...payoff than the firs:. it is more complicated. 20 4.3. Selfish Individuals and Threat Strategies (Model 1) In this section an example is fully

  6. Glue Film Thickness Measurements by Spectral Reflectance

    International Nuclear Information System (INIS)

    Marshall, B.R.

    2010-01-01

    Spectral reflectance was used to determine the thickness of thin glue layers in a study of the effect of the glue on radiance and reflectance measurements of shocked-tin substrates attached to lithium fluoride windows. Measurements based on profilometry of the components were found to be inaccurate due to flatness variations and deformation of the tin substrate under pressure during the gluing process. The accuracy of the spectral reflectance measurements were estimated to be ±0.5 (micro)m, which was sufficient to demonstrate a convincing correlation between glue thickness and shock-generated light.

  7. Glue Film Thickness Measurements by Spectral Reflectance

    Energy Technology Data Exchange (ETDEWEB)

    B. R. Marshall

    2010-09-20

    Spectral reflectance was used to determine the thickness of thin glue layers in a study of the effect of the glue on radiance and reflectance measurements of shocked-tin substrates attached to lithium fluoride windows. Measurements based on profilometry of the components were found to be inaccurate due to flatness variations and deformation of the tin substrate under pressure during the gluing process. The accuracy of the spectral reflectance measurements were estimated to be ±0.5 μm, which was sufficient to demonstrate a convincing correlation between glue thickness and shock-generated light.

  8. Glue-paste linings

    DEFF Research Database (Denmark)

    Fuster-López, Laura; Andersen, Cecil Krarup; Bouillon, Nicolas

    2017-01-01

    Glue-paste linings of (Western) canvas paintings have been performed with a variety of materials throughout history and are present in a very significant amount of artworks in collections in Europe and elsewhere. Cereal flours and animal glues were usually the main ingredients because they were r...

  9. Fibrin glue in ophthalmology

    Directory of Open Access Journals (Sweden)

    Panda Anita

    2009-01-01

    Full Text Available Suturing is a time consuming task in ophthalmology and suture induced irritation and redness are frequent problems. Postoperative wound infection and corneal graft rejection are examples of possible suture related complications. To prevent these complications, ophthalmic surgeons are switching to sutureless surgery. A number of recent developments have established tissue adhesives like cyanoacrylate glue and fibrin glue as attractive alternatives to sutures. A possible and promising new application for tissue adhesives is to provide a platform for tissue engineering. Currently, tissue glue is being used for conjunctival closure following pterygium and strabismus surgery, forniceal reconstruction surgery, amniotic membrane transplantation, lamellar corneal grafting, closure of corneal perforations and descematoceles, management of conjunctival wound leaks after trabeculectomy, lid surgery, adnexal surgery and as a hemostat to minimise bleeding. The purpose of this review is to discuss the currently available information on fibrin glue.

  10. The CostGlue XML Schema

    OpenAIRE

    Furfari, Francesco; Potort?, Francesco; Savić, Dragan

    2008-01-01

    An XML schema for scientific metadata is described. It is used for the CostGlue archival program, developed in the framework of the European Union COST Action 285: "Modelling and simulation tools for research in emerging multi-service telecommunications". The schema is freely available under the GNU LGPL license at http://wnet.isti.cnr.it/software/costglue/schema/2007/CostGlue.xsd, or at its official repository, at http://lt.fe.uni-lj. si/costglue/schema/2007/costglue.xsd.

  11. Next generation of weather generators on web service framework

    Science.gov (United States)

    Chinnachodteeranun, R.; Hung, N. D.; Honda, K.; Ines, A. V. M.

    2016-12-01

    Weather generator is a statistical model that synthesizes possible realization of long-term historical weather in future. It generates several tens to hundreds of realizations stochastically based on statistical analysis. Realization is essential information as a crop modeling's input for simulating crop growth and yield. Moreover, they can be contributed to analyzing uncertainty of weather to crop development stage and to decision support system on e.g. water management and fertilizer management. Performing crop modeling requires multidisciplinary skills which limit the usage of weather generator only in a research group who developed it as well as a barrier for newcomers. To improve the procedures of performing weather generators as well as the methodology to acquire the realization in a standard way, we implemented a framework for providing weather generators as web services, which support service interoperability. Legacy weather generator programs were wrapped in the web service framework. The service interfaces were implemented based on an international standard that was Sensor Observation Service (SOS) defined by Open Geospatial Consortium (OGC). Clients can request realizations generated by the model through SOS Web service. Hierarchical data preparation processes required for weather generator are also implemented as web services and seamlessly wired. Analysts and applications can invoke services over a network easily. The services facilitate the development of agricultural applications and also reduce the workload of analysts on iterative data preparation and handle legacy weather generator program. This architectural design and implementation can be a prototype for constructing further services on top of interoperable sensor network system. This framework opens an opportunity for other sectors such as application developers and scientists in other fields to utilize weather generators.

  12. FIBRIN GLUE DAN APLIKASINYA

    Directory of Open Access Journals (Sweden)

    Agi Harliani S

    2015-08-01

    Full Text Available Fibrin Tissue Adhesive (FTA, Fibrin Sealant (FS or Fibrin Glue (FG are names given to a group of product that lead to the formation of fibrin clot at the site of application. Fibrin Glue represents a new revolution for local haemostatic, which produced by based on the understanding about blood coagulation process. The mechanism of FG mimics the last stage of blood coagulation process. Haemophilia, is a congenital inherited bleeding disorder, characterized by repeated bleeding episodes. The basic pathology is deficiency of factor VIII (hemophilia A or factor IX (hemophilia B. At bleeding episodes, hemophilia patients need replacement therapy. Hemophilia patients need transfusion of cryoprecipitate, Fresh Frozen Plasma (FFP or factor concentrate as replacement therapy. Oral surgery, dental extraction, circumcision, and orthopedic operations are the most important indications for fibrin glue in hemophilia care. As haemostatic local, FG minimizes bleeding, reducing the need of transfusion or factor concentrate, reducing the complication of transfusion, hospitalization and cost.

  13. Glue Guns: Aiming for Safety

    Science.gov (United States)

    Roy, Ken

    2010-01-01

    While glue guns are very useful, there are safety issues. Regardless of the temperature setting, glue guns can burn skin. The teacher should demonstrate and supervise the use of glue guns and have a plan should a student get burned. There should be an initial first aid protocol in place, followed by a visit to the school nurse. An accident report…

  14. Framework for Enabling User-Generated Content

    OpenAIRE

    Nilsson, Karin H

    2012-01-01

    User-generated content, UGC, is a modern topic today and refers to media and creative works created by Internet users and posted on the Internet. More and more application developers wants to offer sharing functionalities in their applications and on their websites. The alternatives of doing so today are to use UGC platforms API, like Facebook and Twitter, to upload the content to that specific platform or to implement the framework ShareKit that enables the user to share their content on mul...

  15. Glue Sniffers with Special Needs.

    Science.gov (United States)

    O'Connor, Denis

    1987-01-01

    Glue sniffing and solvent misuse have seriously affected children and teenagers throughout the United Kingdom. This article discusses glue sniffing in terms of prevalence, association with disability, physical and psychological effects, signs and symptoms, counseling for sniffers, and successful interventions including an approach using videotape…

  16. Clustering for Generating Framework Top-Level Views

    DEFF Research Database (Denmark)

    Schäfer, Thorsten; Aracic, Ivica; Merz, Matthias

    2007-01-01

    To use a framework, developers need to understand its building blocks. In this paper, we present a clustering technique that employs usage data from framework instantiations as examples to produce an overview of a framework's main building blocks as seen from a user's perspective. The evaluation...... of the approach by two case studies shows that the automatically generated building blocks are similar to a manually defined overview created by framework experts, even in cases where only few framework instantiations are available....

  17. BEWARE OF...SUPER GLUES!!

    CERN Multimedia

    2006-01-01

    What happened? A number of accidents have occurred with the use of 'Super Glues'. Some individuals have suffered injuries - severe irritation, or skin bonded together - through getting glue on their face and in their eyes. What are the hazards associated with glues? 'Super Glues' (i.e. cyanoacrylates): Are harmful if swallowed and are chemical irritants to the eyes, respiratory system and skin. Present the risk of polymerization (hardening) leading to skin damage. Be careful ! 'Super Glues' can bond to skin and eyes in seconds. Note: Other glues, resins and hardeners are also chemicals and as such can cause serious damage to the skin, eyes, respiratory or digestive tract. (For example: some components can be toxic, harmful, corrosive, sensitizing agents, etc.). How to prevent accidents in the future? Read the Material Safety Data Sheet (MSDS) for all of the glues you work with. Check the label on the container to find out which of the materials you work with are hazardous. Wear the right Per...

  18. 21 CFR 178.3120 - Animal glue.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Animal glue. 178.3120 Section 178.3120 Food and... and Production Aids § 178.3120 Animal glue. Animal glue may be safely used as a component of articles..., transporting, or holding food, subject to the provisions of this section. (a) Animal glue consists of the...

  19. Framework for Leading Next Generation Science Standards Implementation

    Science.gov (United States)

    Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

    2017-01-01

    In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

  20. A Test Generation Framework for Distributed Fault-Tolerant Algorithms

    Science.gov (United States)

    Goodloe, Alwyn; Bushnell, David; Miner, Paul; Pasareanu, Corina S.

    2009-01-01

    Heavyweight formal methods such as theorem proving have been successfully applied to the analysis of safety critical fault-tolerant systems. Typically, the models and proofs performed during such analysis do not inform the testing process of actual implementations. We propose a framework for generating test vectors from specifications written in the Prototype Verification System (PVS). The methodology uses a translator to produce a Java prototype from a PVS specification. Symbolic (Java) PathFinder is then employed to generate a collection of test cases. A small example is employed to illustrate how the framework can be used in practice.

  1. Is there need for baryons with constituent glue

    International Nuclear Information System (INIS)

    Meissner, U.G.

    1983-01-01

    We investigate the breathing-mode spectrum of the Λ-particle in the framework of a general bag model including confinement via surface tension and volume energy. We show that the experimental states Λ 1/2 (1600) and Λ 1/2 (1800) can be described as radial surface excitations of the Λ. We further comment on a recent paper describing these Λ-excitations as baryons with constituent glue. (orig.)

  2. Policy Framework for the Next Generation Platform as a Service

    DEFF Research Database (Denmark)

    Kentis, Angelos Mimidis; Ollora Zaballa, Eder; Soler, José

    2018-01-01

    The Platform-as-a-Service (PaaS) model, allows service providers to build and deploy their services following streamlined work-flows. However, platforms deployed through the PaaS model can be very diverse in terms of technologies and involved subsystems (e.g. infrastructure, orchestration). Thus,......-wide and technology-agnostic policies to NGPaaS, by means of abstraction of the underlying platforms and the use of generic interfaces. The paper also presents a specific use case for the proposed framework, which targets network-oriented policies......., the means for deploying and managing a service can significantly vary depending on the deployed platform. To address this issue, this paper proposes a policy-based framework designed for the Next Generation Platform-as-a-Service (NGPaaS). This framework allows service providers to define platform...

  3. DARC: Next generation decentralized control framework for robot applications

    DEFF Research Database (Denmark)

    Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

    2013-01-01

    This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry....... It incorporates several new techniques such as a decentralized peer-to-peer architecture, transparent network distribution of the control system, and automatic run-time supervision to guarantee robustness....

  4. Control of DNA hybridization by photoswitchable molecular glue.

    Science.gov (United States)

    Dohno, Chikara; Nakatani, Kazuhiko

    2011-12-01

    Hybridization of DNA is one of the most intriguing events in molecular recognition and is essential for living matter to inherit life beyond generations. In addition to the function of DNA as genetic material, DNA hybridization is a key to control the function of DNA-based materials in nanoscience. Since the hybridization of two single stranded DNAs is a thermodynamically favorable process, dissociation of the once formed DNA duplex is normally unattainable under isothermal conditions. As the progress of DNA-based nanoscience, methodology to control the DNA hybridization process has become increasingly important. Besides many reports using the chemically modified DNA for the regulation of hybridization, we focused our attention on the use of a small ligand as the molecular glue for the DNA. In 2001, we reported the first designed molecule that strongly and specifically bound to the mismatched base pairs in double stranded DNA. Further studies on the mismatch binding molecules provided us a key discovery of a novel mode of the binding of a mismatch binding ligand that induced the base flipping. With these findings we proposed the concept of molecular glue for DNA for the unidirectional control of DNA hybridization and, eventually photoswitchable molecular glue for DNA, which enabled the bidirectional control of hybridization under photoirradiation. In this tutorial review, we describe in detail how we integrated the mismatch binding ligand into photoswitchable molecular glue for DNA, and the application and perspective in DNA-based nanoscience.

  5. Automatic Model Generation Framework for Computational Simulation of Cochlear Implantation

    DEFF Research Database (Denmark)

    Mangado Lopez, Nerea; Ceresa, Mario; Duchateau, Nicolas

    2016-01-01

    . To address such a challenge, we propose an automatic framework for the generation of patient-specific meshes for finite element modeling of the implanted cochlea. First, a statistical shape model is constructed from high-resolution anatomical μCT images. Then, by fitting the statistical model to a patient......'s CT image, an accurate model of the patient-specific cochlea anatomy is obtained. An algorithm based on the parallel transport frame is employed to perform the virtual insertion of the cochlear implant. Our automatic framework also incorporates the surrounding bone and nerve fibers and assigns......Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging...

  6. A platform independent framework for Statecharts code generation

    International Nuclear Information System (INIS)

    Andolfato, L.; Chiozzi, G.; Migliorini, N.; Morales, C.

    2012-01-01

    Control systems for telescopes and their instruments are reactive systems very well suited to be modelled using Statecharts formalism. The World Wide Web Consortium is working on a new standard called SCXML that specifies XML notation to describe Statecharts and provides a well defined operational semantic for run-time interpretation of the SCXML models. This paper presents a generic application framework for reactive non realtime systems based on interpreted Statecharts. The framework consists of a model to text transformation tool and an SCXML interpreter. The tool generates from UML state machine models the SCXML representation of the state machines as well as the application skeletons for the supported software platforms. An abstraction layer propagates the events from the middle-ware to the SCXML interpreter facilitating the support for different software platforms. This project benefits from the positive experience gained in several years of development of coordination and monitoring applications for the telescope control software domain using Model Driven Development technologies. (authors)

  7. A Framework for the Next Generation of Risk Science

    Science.gov (United States)

    Krewski, Daniel; Andersen, Melvin E.; Paoli, Gregory M.; Chiu, Weihsueh A.; Al-Zoughool, Mustafa; Croteau, Maxine C.; Burgoon, Lyle D.; Cote, Ila

    2014-01-01

    Objectives: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. Methods: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making. Results: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making. Conclusions: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice. Citation: Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I. 2014. A framework for the next generation of risk science. Environ Health Perspect 122:796–805; http://dx.doi.org/10.1289/ehp.1307260 PMID:24727499

  8. The GlueX DIRC detector

    Science.gov (United States)

    Barbosa, F.; Bessuille, J.; Chudakov, E.; Dzhygadlo, R.; Fanelli, C.; Frye, J.; Hardin, J.; Kelsey, J.; Patsyuk, M.; Schwarz, C.; Schwiening, J.; Stevens, J.; Shepherd, M.; Whitlatch, T.; Williams, M.

    2017-12-01

    The GlueX DIRC (Detection of Internally Reflected Cherenkov light) detector is being developed to upgrade the particle identification capabilities in the forward region of the GlueX experiment at Jefferson Lab. The GlueX DIRC will utilize four existing decommissioned BaBar DIRC bar boxes, which will be oriented to form a plane roughly 4 m away from the fixed target of the experiment. A new photon camera has been designed that is based on the SuperB FDIRC prototype. The full GlueX DIRC system will consist of two such cameras, with the first planned to be built and installed in 2017. We present the current status of the design and R&D, along with the future plans of the GlueX DIRC detector.

  9. Automatic Model Generation Framework for Computational Simulation of Cochlear Implantation.

    Science.gov (United States)

    Mangado, Nerea; Ceresa, Mario; Duchateau, Nicolas; Kjer, Hans Martin; Vera, Sergio; Dejea Velardo, Hector; Mistrik, Pavel; Paulsen, Rasmus R; Fagertun, Jens; Noailly, Jérôme; Piella, Gemma; González Ballester, Miguel Ángel

    2016-08-01

    Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging. To address such a challenge, we propose an automatic framework for the generation of patient-specific meshes for finite element modeling of the implanted cochlea. First, a statistical shape model is constructed from high-resolution anatomical μCT images. Then, by fitting the statistical model to a patient's CT image, an accurate model of the patient-specific cochlea anatomy is obtained. An algorithm based on the parallel transport frame is employed to perform the virtual insertion of the cochlear implant. Our automatic framework also incorporates the surrounding bone and nerve fibers and assigns constitutive parameters to all components of the finite element model. This model can then be used to study in silico the effects of the electrical stimulation of the cochlear implant. Results are shown on a total of 25 models of patients. In all cases, a final mesh suitable for finite element simulations was obtained, in an average time of 94 s. The framework has proven to be fast and robust, and is promising for a detailed prognosis of the cochlear implantation surgery.

  10. Is deintegrated electric generation efficient; A proposed empirical reserach framework

    Energy Technology Data Exchange (ETDEWEB)

    Fox-Penner, P S [Charles River Associates Incorporated, Boston, Massachusetts (US)

    1990-01-01

    Partial or complete deregulation of public utility industries, which until recently were regulated even in market-driven economics such as the U.S. are examined. The causes and cures of this phenomenon are discussed. The purpose is to present a framework for examining empirically the net benefits to consumers from one particular form of public utility ''deregulation'': separating or deintegrating electricity generators from transmitters, and deregulating the former. The framework has been developed for this application because U.S. public utility law has permitted this particular form of ''deregulation'' to exist alongside traditional utilities for the past ten years. Hence, data are now available for comparing regulated and deregulated power generators and their interaction with the transmission system. More generally, however, the purpose of this article is to argue that the benefits of regulatory change in public utility industries must be examined on a comprehensive basis. It is not sufficient to examine one stage of the vertical production chain and conclude that deregulation will improve or hinder its performance. Rather, the long-range benefits of various industry regimes should be carefully examined from the standpoint of the consumer at the downstream end of the production process. (author) 41 refs.

  11. ABrowse--a customizable next-generation genome browser framework.

    Science.gov (United States)

    Kong, Lei; Wang, Jun; Zhao, Shuqi; Gu, Xiaocheng; Luo, Jingchu; Gao, Ge

    2012-01-05

    With the rapid growth of genome sequencing projects, genome browser is becoming indispensable, not only as a visualization system but also as an interactive platform to support open data access and collaborative work. Thus a customizable genome browser framework with rich functions and flexible configuration is needed to facilitate various genome research projects. Based on next-generation web technologies, we have developed a general-purpose genome browser framework ABrowse which provides interactive browsing experience, open data access and collaborative work support. By supporting Google-map-like smooth navigation, ABrowse offers end users highly interactive browsing experience. To facilitate further data analysis, multiple data access approaches are supported for external platforms to retrieve data from ABrowse. To promote collaborative work, an online user-space is provided for end users to create, store and share comments, annotations and landmarks. For data providers, ABrowse is highly customizable and configurable. The framework provides a set of utilities to import annotation data conveniently. To build ABrowse on existing annotation databases, data providers could specify SQL statements according to database schema. And customized pages for detailed information display of annotation entries could be easily plugged in. For developers, new drawing strategies could be integrated into ABrowse for new types of annotation data. In addition, standard web service is provided for data retrieval remotely, providing underlying machine-oriented programming interface for open data access. ABrowse framework is valuable for end users, data providers and developers by providing rich user functions and flexible customization approaches. The source code is published under GNU Lesser General Public License v3.0 and is accessible at http://www.abrowse.org/. To demonstrate all the features of ABrowse, a live demo for Arabidopsis thaliana genome has been built at http://arabidopsis.cbi.edu.cn/.

  12. ABrowse - a customizable next-generation genome browser framework

    Science.gov (United States)

    2012-01-01

    Background With the rapid growth of genome sequencing projects, genome browser is becoming indispensable, not only as a visualization system but also as an interactive platform to support open data access and collaborative work. Thus a customizable genome browser framework with rich functions and flexible configuration is needed to facilitate various genome research projects. Results Based on next-generation web technologies, we have developed a general-purpose genome browser framework ABrowse which provides interactive browsing experience, open data access and collaborative work support. By supporting Google-map-like smooth navigation, ABrowse offers end users highly interactive browsing experience. To facilitate further data analysis, multiple data access approaches are supported for external platforms to retrieve data from ABrowse. To promote collaborative work, an online user-space is provided for end users to create, store and share comments, annotations and landmarks. For data providers, ABrowse is highly customizable and configurable. The framework provides a set of utilities to import annotation data conveniently. To build ABrowse on existing annotation databases, data providers could specify SQL statements according to database schema. And customized pages for detailed information display of annotation entries could be easily plugged in. For developers, new drawing strategies could be integrated into ABrowse for new types of annotation data. In addition, standard web service is provided for data retrieval remotely, providing underlying machine-oriented programming interface for open data access. Conclusions ABrowse framework is valuable for end users, data providers and developers by providing rich user functions and flexible customization approaches. The source code is published under GNU Lesser General Public License v3.0 and is accessible at http://www.abrowse.org/. To demonstrate all the features of ABrowse, a live demo for Arabidopsis thaliana genome

  13. ABrowse - a customizable next-generation genome browser framework

    Directory of Open Access Journals (Sweden)

    Kong Lei

    2012-01-01

    Full Text Available Abstract Background With the rapid growth of genome sequencing projects, genome browser is becoming indispensable, not only as a visualization system but also as an interactive platform to support open data access and collaborative work. Thus a customizable genome browser framework with rich functions and flexible configuration is needed to facilitate various genome research projects. Results Based on next-generation web technologies, we have developed a general-purpose genome browser framework ABrowse which provides interactive browsing experience, open data access and collaborative work support. By supporting Google-map-like smooth navigation, ABrowse offers end users highly interactive browsing experience. To facilitate further data analysis, multiple data access approaches are supported for external platforms to retrieve data from ABrowse. To promote collaborative work, an online user-space is provided for end users to create, store and share comments, annotations and landmarks. For data providers, ABrowse is highly customizable and configurable. The framework provides a set of utilities to import annotation data conveniently. To build ABrowse on existing annotation databases, data providers could specify SQL statements according to database schema. And customized pages for detailed information display of annotation entries could be easily plugged in. For developers, new drawing strategies could be integrated into ABrowse for new types of annotation data. In addition, standard web service is provided for data retrieval remotely, providing underlying machine-oriented programming interface for open data access. Conclusions ABrowse framework is valuable for end users, data providers and developers by providing rich user functions and flexible customization approaches. The source code is published under GNU Lesser General Public License v3.0 and is accessible at http://www.abrowse.org/. To demonstrate all the features of ABrowse, a live demo for

  14. A Framework for Assessing the Commercialization of Photovoltaic Power Generation

    Science.gov (United States)

    Yaqub, Mahdi

    An effective framework does not currently exist with which to assess the viability of commercializing photovoltaic (PV) power generation in the US energy market. Adopting a new technology, such as utility-scale PV power generation, requires a commercialization assessment framework. The framework developed here assesses the economic viability of a set of alternatives of identified factors. Economic viability focuses on simulating the levelized cost of electricity (LCOE) as a key performance measure to realize `grid parity', or the equivalence between the PV electricity prices and grid electricity prices for established energy technologies. Simulation results confirm that `grid parity' could be achieved without the current federal 30% investment tax credit (ITC) via a combination of three strategies: 1) using economies of scale to reduce the LCOE by 30% from its current value of 3.6 cents/kWh to 2.5 cents/kWh, 2) employing a longer power purchase agreement (PPA) over 30 years at a 4% interest rate, and 3) improving by 15% the "capacity factor", which is the ratio of the total annual generated energy to the full potential annual generation when the utility is continuously operating at its rated output. The lower than commercial-market interest rate of 4% that is needed to realize `grid parity' is intended to replace the current federal 30% ITC subsidy, which does not have a cash inflow to offset the outflow of subsidy payments. The 4% interest rate can be realized through two proposed finance plans: The first plan involves the implementation of carbon fees on polluting power plants to produce the capital needed to lower the utility PPA loan term interest rate from its current 7% to the necessary 4% rate. The second plan entails a proposed public debt finance plan. Under this plan, the US Government leverages its guarantee power to issue bonds and uses the proceeds to finance the construction and operation of PV power plants with PPA loan with a 4% interest rate for a

  15. A framework to describe, analyze and generate interactive motor behaviors.

    Directory of Open Access Journals (Sweden)

    Nathanaël Jarrassé

    Full Text Available While motor interaction between a robot and a human, or between humans, has important implications for society as well as promising applications, little research has been devoted to its investigation. In particular, it is important to understand the different ways two agents can interact and generate suitable interactive behaviors. Towards this end, this paper introduces a framework for the description and implementation of interactive behaviors of two agents performing a joint motor task. A taxonomy of interactive behaviors is introduced, which can classify tasks and cost functions that represent the way each agent interacts. The role of an agent interacting during a motor task can be directly explained from the cost function this agent is minimizing and the task constraints. The novel framework is used to interpret and classify previous works on human-robot motor interaction. Its implementation power is demonstrated by simulating representative interactions of two humans. It also enables us to interpret and explain the role distribution and switching between roles when performing joint motor tasks.

  16. An automated framework for hypotheses generation using literature

    Directory of Open Access Journals (Sweden)

    Abedi Vida

    2012-08-01

    Full Text Available Abstract Background In bio-medicine, exploratory studies and hypothesis generation often begin with researching existing literature to identify a set of factors and their association with diseases, phenotypes, or biological processes. Many scientists are overwhelmed by the sheer volume of literature on a disease when they plan to generate a new hypothesis or study a biological phenomenon. The situation is even worse for junior investigators who often find it difficult to formulate new hypotheses or, more importantly, corroborate if their hypothesis is consistent with existing literature. It is a daunting task to be abreast with so much being published and also remember all combinations of direct and indirect associations. Fortunately there is a growing trend of using literature mining and knowledge discovery tools in biomedical research. However, there is still a large gap between the huge amount of effort and resources invested in disease research and the little effort in harvesting the published knowledge. The proposed hypothesis generation framework (HGF finds “crisp semantic associations” among entities of interest - that is a step towards bridging such gaps. Methodology The proposed HGF shares similar end goals like the SWAN but are more holistic in nature and was designed and implemented using scalable and efficient computational models of disease-disease interaction. The integration of mapping ontologies with latent semantic analysis is critical in capturing domain specific direct and indirect “crisp” associations, and making assertions about entities (such as disease X is associated with a set of factors Z. Results Pilot studies were performed using two diseases. A comparative analysis of the computed “associations” and “assertions” with curated expert knowledge was performed to validate the results. It was observed that the HGF is able to capture “crisp” direct and indirect associations, and provide knowledge

  17. An automated framework for hypotheses generation using literature.

    Science.gov (United States)

    Abedi, Vida; Zand, Ramin; Yeasin, Mohammed; Faisal, Fazle Elahi

    2012-08-29

    In bio-medicine, exploratory studies and hypothesis generation often begin with researching existing literature to identify a set of factors and their association with diseases, phenotypes, or biological processes. Many scientists are overwhelmed by the sheer volume of literature on a disease when they plan to generate a new hypothesis or study a biological phenomenon. The situation is even worse for junior investigators who often find it difficult to formulate new hypotheses or, more importantly, corroborate if their hypothesis is consistent with existing literature. It is a daunting task to be abreast with so much being published and also remember all combinations of direct and indirect associations. Fortunately there is a growing trend of using literature mining and knowledge discovery tools in biomedical research. However, there is still a large gap between the huge amount of effort and resources invested in disease research and the little effort in harvesting the published knowledge. The proposed hypothesis generation framework (HGF) finds "crisp semantic associations" among entities of interest - that is a step towards bridging such gaps. The proposed HGF shares similar end goals like the SWAN but are more holistic in nature and was designed and implemented using scalable and efficient computational models of disease-disease interaction. The integration of mapping ontologies with latent semantic analysis is critical in capturing domain specific direct and indirect "crisp" associations, and making assertions about entities (such as disease X is associated with a set of factors Z). Pilot studies were performed using two diseases. A comparative analysis of the computed "associations" and "assertions" with curated expert knowledge was performed to validate the results. It was observed that the HGF is able to capture "crisp" direct and indirect associations, and provide knowledge discovery on demand. The proposed framework is fast, efficient, and robust in

  18. Serum aluminium levels in glue-sniffer adolescent and in glue containers.

    Science.gov (United States)

    Akay, Cemal; Kalman, Süleyman; Dündaröz, Ruşen; Sayal, Ahmet; Aydin, Ahmet; Ozkan, Yalçin; Gül, Hüsamettin

    2008-05-01

    Glue sniffing is a serious medical problem among teenagers. Various chemical substances such as toluene and benzene containing glues have been reported to be toxic. It has been demonstrated that some toxic metals such as lead are elevated in the blood of solvent-addicted patients. Whereas aluminium is an element that has toxic effects on neurological, hematopoetic system and bone metabolism. We want to determine the serum levels of aluminium in glue-sniffer adolescents in comparison with healthy subjects. In addition, we compared aluminium levels of different commercial glue preparations (i.e. metal and plastic containers), to determine which type of container is better for less aluminium toxicity. We measured serum levels of aluminium in 37 glue-sniffer and 37 healthy subjects using atomic absorption spectrophotometry. The average duration of glue-sniffer was 3.8 +/- 0.8 years. We also measured aluminium levels of 10 commercial glue preparations that seven of them with metal and three with plastic containers. We found that serum levels of aluminium were 63.29 +/- 13.20 ng/ml and 36.7 +/- 8.60 ng/ml in glue-sniffer and in control subjects, respectively (P sniffers, it may be a good step to market of glue preparations in plastic instead of metal containers.

  19. Next generation framework for aquatic modeling of the Earth System

    Science.gov (United States)

    Fekete, B. M.; Wollheim, W. M.; Wisser, D.; Vörösmarty, C. J.

    2009-03-01

    Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES) have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc.) as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities. NextFrAMES was designed primarily for

  20. BCube: A Broker Framework for Next Generation Geoscience

    Science.gov (United States)

    Khalsa, S. S.; Pearlman, J.; Nativi, S.

    2013-12-01

    EarthCube is an NSF initiative that aims to transform the conduct of research through the creation of community-guided cyberinfrastructure enabling the integration information and data across the geosciences. Following an initial phase of concept and community development activities, NSF has made awards for the development of cyberinfrastructure 'building blocks.' In this talk we describe the goals and methods for one of these projects - BCube, for Brokering Building Blocks. BCube addresses the need for effective and efficient multi-disciplinary collaboration and interoperability through the introduction of brokering technologies. Brokers, as information systems middleware, have existed for many years and are found in diverse domains and industries such as financial systems, business-to-business interfaces, medicine and the automotive industry, to name a few. However, the emergence of brokers in science is relatively new and is now being piloted with great promise in cyberinfrastructure and science communities in the U.S., Europe, and elsewhere. Brokers act as intermediaries between information systems that implement well-defined interfaces, providing a bridge between communities using different specifications. The BCube project is helping to build a truly cross-disciplinary, global platform for data providers, cyberinfrastructure developers, and data users to make data more available and interoperable through a brokering framework. Building on the GEOSS Discover and Access Broker (DAB), BCube will develop new modules and services including * Expanded semantic brokering * Business Model support for work flows * Automated metadata generation * Automated linking to services discovered via web crawling * Plug and play for most community service buses * Credential passing for seamless access to data * Ranking of search results from brokered catalogs Because facilitating cross-discipline research involves cultural and well as technical challenges, BCube is also

  1. Photoinduced Bioorthogonal 1,3-Dipolar Poly-cycloaddition Promoted by Oxyanionic Substrates for Spatiotemporal Operation of Molecular Glues.

    Science.gov (United States)

    Hatano, Junichi; Okuro, Kou; Aida, Takuzo

    2016-01-04

    PGlue(PZ), a pyrazoline (PZ)-based fluorescent adhesive which can be generated spatiotemporally in living systems, was developed. Since PGlue(PZ) carries many guanidinium ion (Gu(+)) pendants, it strongly adheres to various oxyanionic substrates through a multivalent salt-bridge interaction. PGlue(PZ) is given by bioorthogonal photopolymerization of a Gu(+)-appended monomer (Glue(TZ)), bearing tetrazole (TZ) and olefinic termini. Upon exposure to UV light, Glue(TZ) transforms into a nitrileimine (NI) intermediate (Glue(NI)), which is eligible for 1,3-dipolar polycycloaddition. However, Glue(NI) in aqueous media can concomitantly be deactivated into Glue(WA) by the addition of water, and the polymerization hardly occurs unless Glue(NI) is concentrated. We found that, even under high dilution, Glue(NI) is concentrated on oxyanionic substrates to a sufficient level for the polymerization, so that their surfaces can be point-specifically functionalized with PGlue(PZ) by the use of a focused beam of UV light. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Bovine glue (BioGlue) is catabolized by enzymatic reaction in the vascular dog model.

    Science.gov (United States)

    Van Belleghem, Yves; Forsyth, Ramses G; Narine, Kishan; Moerman, Annelies; Taeymans, Yves; Van Nooten, Guido J

    2004-06-01

    The aim of the study is to explore the feasibility, patency, and histologic changes of a sutureless vascular anastomotic technique using biological glue as sole fixation method. Eight mongrel dogs (+/-15 kg) underwent direct reanastomosis of their transsected iliac arteries. Both ends were placed on a 5-mm balloon and the anastomosis was secured with biological glue (BioGlue, Cryolife, Kennesaw, GA). No intravascular suture material was used. All survivors were angiographically controlled for patency after 6 weeks and 3 months. Then the animals were euthanized and tissues were obtained for histologic and pathologic examination by light and electron microscopy. All procedures were successful except for 1 animal that died of uncontrollable bleeding at the anastomotic site. All first-time angiographically controlled grafts except three were patent. One animal showed manifest signs of fungal infection. Histology detected early granulocyte infiltration with an important enzymatic reaction adjacent to the surface of glue. Later on, the glue gradually regressed to disappear completely. Fibroblastic neointimal lining was noticed in most of the anastomoses, with some marked differences in the endothelium compared with normal. Good permeability (57%) was observed in this new sutureless anastomotic technique in the canine model. In contrast to previous reported studies we noticed a clear enzymatic breakdown of the glue before total disappearance. It is not yet known to what extend use of the bovine glue was responsible for this phenomenon.

  3. Pythoscape: A framework for generation of large protein similarity networks

    OpenAIRE

    Babbitt, Patricia; Barber, AE; Babbitt, PC

    2012-01-01

    Pythoscape is a framework implemented in Python for processing large protein similarity networks for visualization in other software packages. Protein similarity networks are graphical representations of sequence, structural and other similarities among pr

  4. Requirements for a Next Generation Framework: ATLAS Experience

    CERN Document Server

    Kama, Sami; The ATLAS collaboration

    2015-01-01

    The challenge faced by HEP experiments from the current and expected architectural evolution of CPUs and co-processors is how to successfully exploit concurrency and keep memory consumption within reasonable limits. This is a major change from frameworks which were designed for serial event processing on single core processors in the 2000s. ATLAS has recently considered this problem in some detail through its Future Frameworks Requirements group. Here we report on the major considerations of the group, which was charged with considering the best strategies to exploit current and anticipated CPU technologies. The group has re-examined the basic architecture of event processing and considered how the building blocks of a framework (algorithms, services, tools and incidents) should evolve. The group has also had to take special care to ensure that the use cases of the ATLAS high level trigger are encompassed, which differ in important ways from offline event processing (for example, 99% of events are rejected, w...

  5. Hearing loss in a glue sniffer.

    Science.gov (United States)

    Williams, D M

    1988-10-01

    A case is presented of a 27-year-old glue sniffing woman with sensorineural hearing loss, optic atrophy and global brain damage. This form of addiction has not received much attention as a cause of otologic catastrophes, and should be borne in mind where similar cases come to the otolaryngologist.

  6. SAIL: A Framework for Promoting Next-Generation Word Study

    Science.gov (United States)

    Ganske, Kathy

    2016-01-01

    This article introduces SAIL, an instructional framework designed to help teachers optimize students' learning during small-group word study instruction. Small-group word study interactions afford opportunities for teachers to engage students in thinking, talking, advancing vocabulary knowledge (including general academic vocabulary), and making…

  7. Design and evaluation of a data-driven scenario generation framework for game-based training

    NARCIS (Netherlands)

    Luo, L.; Yin, H.; Cai, W.; Zhong, J.; Lees, M.

    Generating suitable game scenarios that can cater for individual players has become an emerging challenge in procedural content generation. In this paper, we propose a data-driven scenario generation framework for game-based training. An evolutionary scenario generation process is designed with a

  8. Next Generation Simulation Framework for Robotic and Human Space Missions

    Science.gov (United States)

    Cameron, Jonathan M.; Balaram, J.; Jain, Abhinandan; Kuo, Calvin; Lim, Christopher; Myint, Steven

    2012-01-01

    The Dartslab team at NASA's Jet Propulsion Laboratory (JPL) has a long history of developing physics-based simulations based on the Darts/Dshell simulation framework that have been used to simulate many planetary robotic missions, such as the Cassini spacecraft and the rovers that are currently driving on Mars. Recent collaboration efforts between the Dartslab team at JPL and the Mission Operations Directorate (MOD) at NASA Johnson Space Center (JSC) have led to significant enhancements to the Dartslab DSENDS (Dynamics Simulator for Entry, Descent and Surface landing) software framework. The new version of DSENDS is now being used for new planetary mission simulations at JPL. JSC is using DSENDS as the foundation for a suite of software known as COMPASS (Core Operations, Mission Planning, and Analysis Spacecraft Simulation) that is the basis for their new human space mission simulations and analysis. In this paper, we will describe the collaborative process with the JPL Dartslab and the JSC MOD team that resulted in the redesign and enhancement of the DSENDS software. We will outline the improvements in DSENDS that simplify creation of new high-fidelity robotic/spacecraft simulations. We will illustrate how DSENDS simulations are assembled and show results from several mission simulations.

  9. Towards an analytical framework for tailoring supercontinuum generation.

    Science.gov (United States)

    Castelló-Lurbe, David; Vermeulen, Nathalie; Silvestre, Enrique

    2016-11-14

    A fully analytical toolbox for supercontinuum generation relying on scenarios without pulse splitting is presented. Furthermore, starting from the new insights provided by this formalism about the physical nature of direct and cascaded dispersive wave emission, a unified description of this radiation in both normal and anomalous dispersion regimes is derived. Previously unidentified physics of broadband spectra reported in earlier works is successfully explained on this basis. Finally, a foundry-compatible few-millimeters-long silicon waveguide allowing octave-spanning supercontinuum generation pumped at telecom wavelengths in the normal dispersion regime is designed, hence showcasing the potential of this new analytical approach.

  10. An Empirical Generative Framework for Computational Modeling of Language Acquisition

    Science.gov (United States)

    Waterfall, Heidi R.; Sandbank, Ben; Onnis, Luca; Edelman, Shimon

    2010-01-01

    This paper reports progress in developing a computer model of language acquisition in the form of (1) a generative grammar that is (2) algorithmically learnable from realistic corpus data, (3) viable in its large-scale quantitative performance and (4) psychologically real. First, we describe new algorithmic methods for unsupervised learning of…

  11. Pythoscape: a framework for generation of large protein similarity networks.

    Science.gov (United States)

    Barber, Alan E; Babbitt, Patricia C

    2012-11-01

    Pythoscape is a framework implemented in Python for processing large protein similarity networks for visualization in other software packages. Protein similarity networks are graphical representations of sequence, structural and other similarities among proteins for which pairwise all-by-all similarity connections have been calculated. Mapping of biological and other information to network nodes or edges enables hypothesis creation about sequence-structure-function relationships across sets of related proteins. Pythoscape provides several options to calculate pairwise similarities for input sequences or structures, applies filters to network edges and defines sets of similar nodes and their associated data as single nodes (termed representative nodes) for compression of network information and output data or formatted files for visualization.

  12. [Chemical hazards when working with solvent glues].

    Science.gov (United States)

    Domański, Wojciech; Makles, Zbigniew

    2012-01-01

    Solvent glues are used in a wide variety of industries, e.g., textile, footwear and rubber. The problem of workers' exposure to solvent vapors is rarely tackled within the area of occupational safety and health in small and medium-sized enterprises. In order to assess exposure to solvents, organic solvents emitted by glues were identified in the samples of workplace air. The concentration of acetone, benzene, cyclohexane, ethylbenzene, n-hexane, methylcyclohexane, butyl acetate and toluene were determined. The obtained results evidenced the presence of cyclohexane, ethylbenzene, ethylcyclohexane, heptane, n-hexane, o-xylene, methylcyclohexane, methylcyclopentane, butyl acetate and toluene in workplace air. The concentration of those compounds in workplace air was low, usually below 0.15 of MAC. At some workstations the presence of benzene was also observed. Occupational risk was assessed at workstations where gluing took place. It showed that the risk at those workstations was medium or low.

  13. Glue therapy in hemoptysis: A new technique

    Directory of Open Access Journals (Sweden)

    Rakesh K Chawla

    2012-01-01

    Full Text Available Hemoptysis is defined as the spitting of blood derived from the lungs or bronchial tubes as a result of pulmonary or bronchial hemorrhage. There is a large chunk of patients with hemoptysis who do not respond to conservative treatment including use of cough suppressants, antibiotics, vitamin C, hemostatics, and anxiolytics. The advanced management of such a situation is bronchial artery embolization (BAE or open thoracic surgery, which is often not possible. We have attempted a cheap, effective, and safe alternative in the form of intrabronchial instillation of glue (n-butyl cyanoacrylate under vision with the help of a therapeutic video bronchoscope (OLYMPUS T-180. The glue is instilled through a polyethylene catheter placed through the working channel of the video bronchoscope.

  14. Acute nonlymphocytic leukemia in a glue sniffer.

    Science.gov (United States)

    Caligiuri, M A; Early, A P; Marinello, M J; Preisler, H D

    1985-09-01

    A 17-year-old white male with a past history of chronic inhalational abuse of plastic glue was referred to our institution for sore throat, cervical adenopathy, and an abnormal peripheral blood smear. A diagnosis of acute myelomonocytic leukemia was made and abnormalities in cytogenetic studies were demonstrated. Specific inquiry regarding this form of drug exposure should be pursued when searching for possible etiologies of malignant disease.

  15. On the glue content in heavy quarkonia

    International Nuclear Information System (INIS)

    Gromes, D.

    2003-01-01

    Starting with two coupled Bethe-Salpeter equations for the quark-antiquark, and for the quark-glue-antiquark component of the quarkonium, we solve the bound state equations perturbatively. The resulting admixture of glue can be partially understood in a semiclassical way; one has, however, to take care of the different use of time ordered versus retarded Green functions. Subtle questions concerning the precise definition of the equal time wave function arise, because the wave function for the Coulomb gluon is discontinuous with respect to the relative time of the gluon. A striking feature is that a one loop non-abelian graph contributes to the same order as tree graphs, because the couplings of transverse gluons in the tree graphs are suppressed in the non-relativistic bound state, while the higher order loop graph can couple to quarks via non-suppressed Coulomb gluons. We also calculate the amplitude for quark and antiquark at zero distance in the quark-glue-antiquark component of the P-state. This quantity is of importance for annihilation decays of P-states. It shows a remarkable compensation between the tree graph and the non-abelian loop graph contribution. An extension of our results to include non-perturbative effects is possible. (orig.)

  16. Contact dermatitis to ethyl-cyanoacrylate-containing glue.

    Science.gov (United States)

    Belsito, D V

    1987-10-01

    3 patients with contact dermatitis to an ethyl cyanoacrylate glue are presented. Although reactions to cyanoacrylate glues are considered rare, more widespread use of these products by nail salons is likely to be associated with an increased incidence of positive reactions. All 3 of our patients came into contact with the glue during "nail wrapping". In this process, ethyl cyanoacrylate or another "instant glue" is used to adhere glue-impregnated silk or linen to the nail plate which is then filed to shape the nail. This procedure creates fine acrylic-containing dust which may facilitate an allergic response. Fine particulate matter may be transferred to other distant cutaneous sites, such as the eyelids, resulting in more widespread cutaneous eruptions. Dermatologists in areas where nail wrapping is becoming more fashionable are advised to be alert to potential cyanoacrylate glue allergies which present as periungual eczema which may be associated with eyelid dermatitis and features of nummular dermatitis particularly over the dorsal hand.

  17. A Generalized Framework for Modeling Next Generation 911 Implementations.

    Energy Technology Data Exchange (ETDEWEB)

    Kelic, Andjelka; Aamir, Munaf Syed; Kelic, Andjelka; Jrad, Ahmad M.; Mitchell, Roger

    2018-02-01

    This document summarizes the current state of Sandia 911 modeling capabilities and then addresses key aspects of Next Generation 911 (NG911) architectures for expansion of existing models. Analysis of three NG911 implementations was used to inform heuristics , associated key data requirements , and assumptions needed to capture NG911 architectures in the existing models . Modeling of NG911 necessitates careful consideration of its complexity and the diversity of implementations. Draft heuristics for constructing NG911 models are pres ented based on the analysis along with a summary of current challenges and ways to improve future NG911 modeling efforts . We found that NG911 relies on E nhanced 911 (E911) assets such as 911 selective routers to route calls originating from traditional tel ephony service which are a majority of 911 calls . We also found that the diversity and transitional nature of NG911 implementations necessitates significant and frequent data collection to ensure that adequate model s are available for crisis action support .

  18. A life-cycle based decision-making framework for electricity generation system planning

    Energy Technology Data Exchange (ETDEWEB)

    Norrie, S.J.; Fang, L. [Ryerson Polytechnic Univ., Toronto, ON (Canada). Environmental Applied Science and Management Graduate Program

    2006-07-01

    This paper proposed a framework for the consideration of multiple objectives in the long-term planning of electricity generation systems. The framework was comprised of 3 components: (1) information based on life-cycle inventories of electricity generation technologies; (2) a set of alternative scenarios to be evaluated and ranked using the framework; and (3) stakeholder values for decision objectives. Scenarios were developed to represent a set of future conditions, and values were derived through the use of questionnaires. Planning for electricity generation in Ontario was selected as a test case for the DM framework. Three scenarios were presented: (1) a business as usual scenario characterized by large, central power plants; (2) a mix of central power plants, distributed generation, and advanced conventional fuel technologies; and (3) small-scale distributed and renewable energy sources and aggressive demand-side management. The life-cycle based information from the scenario evaluation was used to estimate the performance of each scenario on the established decision criteria. Results showed that scenario 3 was the closest to achieving the fundamental objectives according to the decision criteria. It was concluded that the DM framework showed that the use of holistic environmental information and preferential information for multiple objectives can be integrated into a framework that openly and consistently evaluates a set of alternative scenarios. 31 refs., 7 tabs., 4 figs.

  19. Rejoining of cut wounds by engineered gelatin-keratin glue.

    Science.gov (United States)

    Thirupathi Kumara Raja, S; Thiruselvi, T; Sailakshmi, G; Ganesh, S; Gnanamani, A

    2013-08-01

    Rejoining of cut tissue ends of a critical site challenges clinicians. The toxicity, antigenicity, low adhesive strength, flexibility, swelling and cost of the currently employed glue demands an alternative. Engineered gelatin-keratin glue (EGK-glue) described in the present study was found to be suitable for wet tissue approximation. EGK-glue was prepared by engineering gelatin with caffeic acid using EDC and conjugating with keratin by periodate oxidation. UV-visible, (1)H NMR and circular dichroism analyses followed by experiments on gelation time, rheology, gel adhesive strength (in vitro), wet tissue approximation (in vivo), H&E staining of tissue sections at scheduled time intervals and tensile strength of the healed skin were carried out to assess the effectiveness of the EGK-glue in comparison with fibrin glue and cyanoacrylate. Results of UV-visible, NMR and CD analyses confirmed the functionalization and secondary structural changes. Increasing concentration of keratin reduces the gelation time (glue for clinical applications. Tissue approximation property assessed using the incision wound model (Wistar strain) in comparison with cyanoacrylate and fibrin glue suggested, that EGK-glue explicitly accelerates the rejoining of tissue with a 1.86 fold increase in skin tensile strength after healing. Imparting quinone moiety to gelatin-keratin conjugates through caffeic acid and a weaker oxidizing agent provides an adhesive glue with appreciable strength, and hemocompatible, cytocompatible and biodegradable properties, which, rejoin the cut tissue ends effectively. EGK-glue obtained in the present study finds wide biomedical/clinical applications. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. Biomechanical and histologic evaluation of two application forms of surgical glue for mesh fixation to the abdominal wall.

    Science.gov (United States)

    Ortillés, Á; Pascual, G; Peña, E; Rodríguez, M; Pérez-Köhler, B; Mesa-Ciller, C; Calvo, B; Bellón, J M

    2017-11-01

    The use of an adhesive for mesh fixation in hernia repair reduces chronic pain and minimizes tissue damage in the patient. This study was designed to assess the adhesive properties of a medium-chain (n-butyl) cyanoacrylate glue applied as drops or as a spray in a biomechanical and histologic study. Both forms of glue application were compared to the use of simple-loose or continuous-running polypropylene sutures for mesh fixation. Eighteen adult New Zealand White rabbits were used. For mechanical tests in an ex vivo and in vivo study, patches of polypropylene mesh were fixed to an excised fragment of healthy abdominal tissue or used to repair a partial abdominal wall defect in the rabbit respectively. Depending on the fixation method used, four groups of 12 implants each or 10 implants each respectively for the ex vivo and in vivo studies were established: Glue-Drops, Glue-Spray, Suture-Simple and Suture-Continuous. Biomechanical resistance in the ex vivo implants was tested five minutes after mesh fixation. In vivo implants for biomechanical and histologic assessment were collected at 14 days postimplant. In the ex vivo study, the continuous suture implants showed the highest failure sample tension, while the implants fixed with glue showed lower failure sample tension values. However, the simple and continuous suture implants returned the highest stretch values. In the in vivo implants, failure sample tension values were similar among groups while the implants fixed with a continuous running suture had the higher stretch values, and the glue-fixed implants the lower stretch values. All meshes showed good tissue integration within the host tissue regardless of the fixation method used. Our histologic study revealed the generation of a denser, more mature repair tissue when the cyanoacrylate glue was applied as a spray rather than as drops. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. A planning and analysis framework for evaluating distributed generation and utility strategies

    International Nuclear Information System (INIS)

    Ault, Graham W.

    2000-01-01

    The numbers of smaller scale distributed power generation units connected to the distribution networks of electricity utilities in the UK and elsewhere have grown significantly in recent years. Numerous economic and political drivers have stimulated this growth and continue to provide the environment for future growth in distributed generation. The simple fact that distributed generation is independent from the distribution utility complicates planning and operational tasks for the distribution network. The uncertainty relating to the number, location and type of distributed generating units to connect to the distribution network in the future makes distribution planning a particularly difficult activity. This thesis concerns the problem of distribution network and business planning in the era of distributed generation. A distributed generation strategic analysis framework is proposed to provide the required analytical capability and planning and decision making framework to enable distribution utilities to deal effectively with the challenges and opportunities presented to them by distributed generation. The distributed generation strategic analysis framework is based on the best features of modern planning and decision making methodologies and facilitates scenario based analysis across many utility strategic options and uncertainties. Case studies are presented and assessed to clearly illustrate the potential benefits of such an approach to distributed generation planning in the UK electricity supply industry. (author)

  2. Peptide assembly-driven metal-organic framework (MOF) motors for micro electric generators.

    Science.gov (United States)

    Ikezoe, Yasuhiro; Fang, Justin; Wasik, Tomasz L; Uemura, Takashi; Zheng, Yongtai; Kitagawa, Susumu; Matsui, Hiroshi

    2015-01-14

    Peptide-metal-organic framework (Pep-MOF) motors, whose motions are driven by anisotropic surface tension gradients created via peptide self-assembly around frameworks, can rotate microscopic rotors and magnets fast enough to generate an electric power of 0.1 μW. A new rigid Pep-MOF motor can be recycled by refilling the peptide fuel into the nanopores of the MOF. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Mussel glue protein has an open conformation.

    Science.gov (United States)

    Williams, T; Marumo, K; Waite, J H; Henkens, R W

    1989-03-01

    Both native glue protein from marine mussels and a synthetic nonhydroxylated analog were analyzed by far-uv CD under a variety of conditions. Analysis of the CD spectra using various models strongly suggest a primarily random coil structure for both forms of the protein, a fact also supported by the absence of spectral change for the glue protein upon dilution into 6 M guanidine hydrochloride. The nonhydroxylated analog, which consists of 20 repeats of the peptide sequence Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys, was further characterized by enzyme modification using mushroom tyrosinase. Enzymatic hydroxylation of tyrosines was found to be best fit by a model containing two rate constants, 5.6 (+/- 0.6) X 10(-3) and 7.2 (+/- 0.3) X 10(-2) min-1. At equilibrium, HPLC analysis of digests showed nearly 100% conversion of Tyr-9 and only 15 to 35% conversion of Tyr-5. The Chou and Fasman rules for predicting structure were applied to the repeat sequence listed above. The rules predict the absence of alpha helix and beta pleated sheets in the structure of this peptide. On the other hand, beta turns are predicted to be present with Tyr-5 being in the region of highest probability. These data suggest that the protein in solution has only a small amount of secondary structure.

  4. Extending the Framework of Generativity Theory Through Research: A Qualitative Study.

    Science.gov (United States)

    Rubinstein, Robert L; Girling, Laura M; de Medeiros, Kate; Brazda, Michael; Hannum, Susan

    2015-08-01

    Based on ethnographic interviews, we discuss three ideas we believe will expand knowledge of older informants' thoughts about and representations of generativity. We adapt the notion of "dividuality" as developed in cultural anthropology to reframe ideas on generativity. The term dividuality refers to a condition of interpersonal or intergenerational connectedness, as distinct from individuality. We also extend previous definitions of generativity by identifying both objects of generative action and temporal and relational frameworks for generative action. We define 4 foci of generativity (people, groups, things, and activities) and 4 spheres of generativity (historical, familial, individual, and relational) based in American culture and with which older informants could easily identify. The approach outlined here also discusses a form of generativity oriented to the past in which relationships with persons in senior generations form a kind of generative action since they are involved in caring for the origins of the self and hence of future generative acts. These 3 elements of a new framework will allow researchers to pose critical questions about generativity among older adults. Such questions include (a) How is the self, as culturally constituted, involved in generative action? and (b) What are the types of generativity within the context of American culture and how are they spoken about? Each of the above points is directly addressed in the data we present below. We defined these domains through extended ethnographic interviews with 200 older women. The article addresses some new ways of thinking about generativity as a construct, which may be useful in understanding the cultural personhood of older Americans. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. An object-oriented framework for the hadronic Monte-Carlo event generators

    International Nuclear Information System (INIS)

    Amelin, N.; Komogorov, M.

    1999-01-01

    We advocate the development of an object-oriented framework for the hadronic Monte-Carlo (MC) event generators. The hadronic MC user and developer requirements are discussed as well as the hadronic model commonalities. It is argued that the development of a framework is in favour of taking into account of model commonalities since common means are stable and can be developed only at once. Such framework can provide different possibilities to have user session more convenient and productive, e.g., an easy access and edition of any model parameter, substitution of the model components by the alternative model components without changing the code, customized output, which offers either full information about history of generated event or specific information about reaction final state, etc. Such framework can indeed increase the productivity of a hadronic model developer, particularly, due to the formalization of the hadronic model component structure and model component collaborations. The framework based on the component approach opens a way to organize a library of the hadronic model components, which can be considered as the pool of hadronic model building blocks. Basic features, code structure and working examples of the first framework version for the hadronic MC models, which has been built as the starting point, are shortly explained

  6. Conceptual framework for the study of food waste generation and prevention in the hospitality sector.

    Science.gov (United States)

    Papargyropoulou, Effie; Wright, Nigel; Lozano, Rodrigo; Steinberger, Julia; Padfield, Rory; Ujang, Zaini

    2016-03-01

    Food waste has significant detrimental economic, environmental and social impacts. The magnitude and complexity of the global food waste problem has brought it to the forefront of the environmental agenda; however, there has been little research on the patterns and drivers of food waste generation, especially outside the household. This is partially due to weaknesses in the methodological approaches used to understand such a complex problem. This paper proposes a novel conceptual framework to identify and explain the patterns and drivers of food waste generation in the hospitality sector, with the aim of identifying food waste prevention measures. This conceptual framework integrates data collection and analysis methods from ethnography and grounded theory, complemented with concepts and tools from industrial ecology for the analysis of quantitative data. A case study of food waste generation at a hotel restaurant in Malaysia is used as an example to illustrate how this conceptual framework can be applied. The conceptual framework links the biophysical and economic flows of food provisioning and waste generation, with the social and cultural practices associated with food preparation and consumption. The case study demonstrates that food waste is intrinsically linked to the way we provision and consume food, the material and socio-cultural context of food consumption and food waste generation. Food provisioning, food consumption and food waste generation should be studied together in order to fully understand how, where and most importantly why food waste is generated. This understanding will then enable to draw detailed, case specific food waste prevention plans addressing the material and socio-economic aspects of food waste generation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Straightforward Generation of Pillared, Microporous Graphene Frameworks for Use in Supercapacitors.

    Science.gov (United States)

    Yuan, Kai; Xu, Yazhou; Uihlein, Johannes; Brunklaus, Gunther; Shi, Lei; Heiderhoff, Ralf; Que, Mingming; Forster, Michael; Chassé, Thomas; Pichler, Thomas; Riedl, Thomas; Chen, Yiwang; Scherf, Ullrich

    2015-11-01

    Microporous, pillared graphene-based frameworks are generated in a simple functionalization/coupling procedure starting from reduced graphene oxide. They are used for the fabrication of high-performance supercapacitor devices. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Comparison of two fibrin glues in anastomoses and skin closure.

    Science.gov (United States)

    Park, W; Kim, W H; Lee, C H; Kim, D Y; Choi, J H; Huh, J W; Sung, H M; Kim, I S; Kweon, O K

    2002-09-01

    To control intra-operative haemorrhage, fibrin glues are preferred by many surgeons because of their biological advantages and convenience of application. Manufacturers have developed a few kinds of fibrin glues with a little difference in their composition. This study was to compare the effectiveness of two commercially available fibrin glues; Greenplast (Green Cross P. D. Company, Yongin, Korea) and Tisseel (Baxter-Immuno AG, Vienna, Austria). They were applied experimentally to several kinds of surgery in dogs - renal vessel anastomosis, partial splenectomy, intestinal anastomosis and incision skin wound - and evaluated for their haemostatic and adhesive effects. When the two glues were applied in renal vessel anastomosis, the amount of haemorrhage in artery and vein decreased significantly. They also decreased the haemorrhage in partial splenectomy. At 10 min after application of the glues to an incision skin wound, the tensile strengths developed were significantly higher than that of control. The present study indicates that two-component fibrin glues have a haemostatic effect as a mechanical barrier in renal vessel anastomosis and an adhesive effect in the early stage of incision skin wound closure, and the two glues have similar effects with no complications.

  9. Histological effects of fibrin glue and synthetic tissue glues on the spinal cord: are they safe to use?

    Science.gov (United States)

    Kalsi, Pratipal; Thom, Maria; Choi, David

    2017-12-01

    Fibrin glues such as Tisseel ® have been established in neurosurgery for over thirty years. They are recommended for extradural use but have intradural applications. Brachial plexus reimplantation after trauma requires intradural fibrin glue because reimplanted nerves cannot be sutured to the spinal cord. Recently synthetic glues have become popular in spinal surgery but there is limited information about their safety. Our study compared the histological effects of Tisseel ® , Adherus ® and BioGlue ® on spinal cord using our rat brachial plexus repair model. Randomised observational animal study. Forty-one Sprague-Dawley rats divided in to control (n = 9), Tisseel ® (n = 8), BioGlue ® (n = 10) and Adherus ® (n = 14) groups. Under general anaesthesia a posterior midline cervical incision was made and hemi-laminectomies performed at C7 and T1. Dura was opened and T1 dorsal root transected and repositioned on the spinal cord. Two drops of Tisseel ® , BioGlue ® , Adherus ® or no glue (control) were applied over the cut nerve and cord. At days 7, 14 and 28 rats were euthanized, processed and sections stained with Haematoxylin & Eosin and evaluated blind by a neuropathologist. Control and Tisseel ® groups showed only mild focal inflammation in the cord. Adherus ® and Bioglue ® groups showed evidence of spinal cord inflammation and degeneration. All BioGlue ® and Adherus ® rats had evidence of distortion of the cord from the glue mass at all time points. Two BioGlue ® -treated and one Adherus ® -treated rat developed a hemiparesis. One BioGlue ® rat developed hind limb paralysis. One BioGlue ® rat failed to wake up at the end of the procedure. There were no complications in control and Tisseel ® groups. Tisseel ® caused a similar inflammatory response to control and may be used on spinal cord. BioGlue ® and Adherus ® should be applied thinly for a watertight dural closure but intradural use and contact with spinal tissue must be

  10. Generalized Likelihood Uncertainty Estimation (GLUE) Using Multi-Optimization Algorithm as Sampling Method

    Science.gov (United States)

    Wang, Z.

    2015-12-01

    For decades, distributed and lumped hydrological models have furthered our understanding of hydrological system. The development of hydrological simulation in large scale and high precision elaborated the spatial descriptions and hydrological behaviors. Meanwhile, the new trend is also followed by the increment of model complexity and number of parameters, which brings new challenges of uncertainty quantification. Generalized Likelihood Uncertainty Estimation (GLUE) has been widely used in uncertainty analysis for hydrological models referring to Monte Carlo method coupled with Bayesian estimation. However, the stochastic sampling method of prior parameters adopted by GLUE appears inefficient, especially in high dimensional parameter space. The heuristic optimization algorithms utilizing iterative evolution show better convergence speed and optimality-searching performance. In light of the features of heuristic optimization algorithms, this study adopted genetic algorithm, differential evolution, shuffled complex evolving algorithm to search the parameter space and obtain the parameter sets of large likelihoods. Based on the multi-algorithm sampling, hydrological model uncertainty analysis is conducted by the typical GLUE framework. To demonstrate the superiority of the new method, two hydrological models of different complexity are examined. The results shows the adaptive method tends to be efficient in sampling and effective in uncertainty analysis, providing an alternative path for uncertainty quantilization.

  11. Supporting an Object-Oriented Approach to Unit Generator Development: The Csound Plugin Opcode Framework

    Directory of Open Access Journals (Sweden)

    Victor Lazzarini

    2017-09-01

    Full Text Available This article presents a new framework for unit generator development for Csound, supporting a full object-oriented programming approach. It introduces the concept of unit generators and opcodes, and its centrality with regards to music programming languages in general, and Csound in specific. The layout of an opcode from the perspective of the Csound C-language API is presented, with some outline code examples. This is followed by a discussion which places the unit generator within the object-oriented paradigm and the motivation for a full C++ programming support, which is provided by the Csound Plugin Opcode Framework (CPOF. The design of CPOF is then explored in detail, supported by several opcode examples. The article concludes by discussing two key applications of object-orientation and their respective instances in the Csound code base.

  12. An optimization framework for the integrated planning of generation and transmission expansion in interconnected power systems

    International Nuclear Information System (INIS)

    Guerra, Omar J.; Tejada, Diego A.; Reklaitis, Gintaras V.

    2016-01-01

    Highlights: • A novel optimization framework for the design and planning of interconnected power systems is proposed. • The framework integrates generation and transmission capacity expansion planning. • Reserve and emission constraints are included. • Business as usual and CO_2 mitigation policy scenarios are evaluated. • Reconfiguration of existing power generation technologies is the most cost-effective option for CO_2 emissions mitigation. - Abstract: Energy, and particularly electricity, has played and will continue to play a very important role in the development of human society. Electricity, which is the most flexible and manageable energy form, is currently used in a variety of activities and applications. For instance, electricity is used for heating, cooling, lighting, and for operating electronic appliances and electric vehicles. Nowadays, given the rapid development and commercialization of technologies and devices that rely on electricity, electricity demand is increasing faster than overall primary energy supply. Consequently, the design and planning of power systems is becoming a progressively more important issue in order to provide affordable, reliable and sustainable energy in timely fashion, not only in developed countries but particularly in developing economies where electricity demand is increasing even faster. Power systems are networks of electrical devices, such as power plants, transformers, and transmission lines, used to produce, transmit, and supply electricity. The design and planning of such systems require the selection of generation technologies, along with the capacity, location, and timing of generation and transmission capacity expansions to meet electricity demand over a long-term horizon. This manuscript presents a comprehensive optimization framework for the design and planning of interconnected power systems, including the integration of generation and transmission capacity expansion planning. The proposed

  13. Tailored motivational message generation: A model and practical framework for real-time physical activity coaching.

    Science.gov (United States)

    Op den Akker, Harm; Cabrita, Miriam; Op den Akker, Rieks; Jones, Valerie M; Hermens, Hermie J

    2015-06-01

    This paper presents a comprehensive and practical framework for automatic generation of real-time tailored messages in behavior change applications. Basic aspects of motivational messages are time, intention, content and presentation. Tailoring of messages to the individual user may involve all aspects of communication. A linear modular system is presented for generating such messages. It is explained how properties of user and context are taken into account in each of the modules of the system and how they affect the linguistic presentation of the generated messages. The model of motivational messages presented is based on an analysis of existing literature as well as the analysis of a corpus of motivational messages used in previous studies. The model extends existing 'ontology-based' approaches to message generation for real-time coaching systems found in the literature. Practical examples are given on how simple tailoring rules can be implemented throughout the various stages of the framework. Such examples can guide further research by clarifying what it means to use e.g. user targeting to tailor a message. As primary example we look at the issue of promoting daily physical activity. Future work is pointed out in applying the present model and framework, defining efficient ways of evaluating individual tailoring components, and improving effectiveness through the creation of accurate and complete user- and context models. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Properties of invariant modelling and invariant glueing of vector fields

    International Nuclear Information System (INIS)

    Petukhov, V.R.

    1987-01-01

    Invariant modelling and invariant glueing of both continuous (rates and accelerations) and descrete vector fields, gradient and divergence cases are considered. The following appendices are discussed: vector fields in crystals, crystal disclinations, topological charges and their fields

  15. Safety of Synthetic Glue Used for Laparoscopic Prolapse Treatment.

    Science.gov (United States)

    Sarasa Castelló, Núria; Toth, Alexandra; Canis, Michel; Botchorishvilli, Revaz

    2017-12-29

    We detected mesh erosion and serious postoperative complications in 3 women after performing laparoscopic promontofixation (LPF) using glue for mesh fixation. Glue, largely used in hernia surgery repair, is proposed by some gynecologic surgeons because it saves time and is easier to use than traditional sutures. We report 3 cases of postoperative complications after LPF in which glue had been used and provide research in the published literature about the use of glue in LPF. A research of glue use in gynecology mesh fixation was performed through PubMed on October 2016. The search was done using the Medical Subject Heading terms "POP" & "Laparoscopy" & "surgical Mesh" and the word either "glue" or "adhesive. Only 2 articles were found: Willecocq et al [1] and Estrade et al [2]. Neither study focused on postoperative complications. In this publication, we accurately edited video surgeries with an instructive purpose. University Hospital of Clermont-Ferrand, France. Patient A, a 65-year-old woman, complained of pelvic pain and vaginal discharge 1 month after LPF (polypropylene mesh and glue had been used). Wall mesh exposure and purulent discharge were noted. She received antibiotics and underwent mesh ablation surgery; debris of the glue was easily identified. Patient B, a 65-year-old lady with previous hysterectomy consulted for a bulging feeling in her vagina (classification: cystocele +2; rectocele +3 stage). An LPF was performed using polypropylene soft nonabsorbable mesh and glue. One month later, an apical defect of vaginal epithelialization was detected; she received long estrogenic local treatment but had to undergo surgery when presenting malodorous discharge and mesh exposure. The exposed mesh was removed, and pieces of glue were identified, having avoided mesh attachment. Patient C had a previous abdominal hysterectomy and promontofixation using a polyester mesh with glue. She consulted to us for vaginal mesh erosion covered with purulent discharge 3

  16. ng: What next-generation languages can teach us about HENP frameworks in the manycore era

    International Nuclear Information System (INIS)

    Binet, Sébastien

    2011-01-01

    Current High Energy and Nuclear Physics (HENP) frameworks were written before multicore systems became widely deployed. A 'single-thread' execution model naturally emerged from that environment, however, this no longer fits into the processing model on the dawn of the manycore era. Although previous work focused on minimizing the changes to be applied to the LHC frameworks (because of the data taking phase) while still trying to reap the benefits of the parallel-enhanced CPU architectures, this paper explores what new languages could bring to the design of the next-generation frameworks. Parallel programming is still in an intensive phase of R and D and no silver bullet exists despite the 30+ years of literature on the subject. Yet, several parallel programming styles have emerged: actors, message passing, communicating sequential processes, task-based programming, data flow programming, ... to name a few. We present the work of the prototyping of a next-generation framework in new and expressive languages (python and Go) to investigate how code clarity and robustness are affected and what are the downsides of using languages younger than FORTRAN/C/C++.

  17. Peptide Assembly-Driven Metal-Organic Framework (MOF) Motors for Micro Electric Generator

    Science.gov (United States)

    Ikezoe, Yasuhiro; Fang, Justin; Wasik, Tomasz L.; Uemura, Takashi; Zheng, Yongtai; Kitagawa, Susumu

    2014-01-01

    Peptide-MOF motors, whose motions are driven by anisotropic surface gradients created via peptide self-assembly around nanopores of MOFs, can rotate microscopic rotors and magnet fast enough to generate electric power of 0.1 µW. To make the peptide-MOF generator recyclable, a new MOF is applied as a host motor engine, which has a more rigid framework with higher H2O affinity so that peptide release occurs more efficiently via guest exchange without the destruction of MOF. PMID:25418936

  18. Sherlock: A Semi-automatic Framework for Quiz Generation Using a Hybrid Semantic Similarity Measure.

    Science.gov (United States)

    Lin, Chenghua; Liu, Dong; Pang, Wei; Wang, Zhe

    In this paper, we present a semi-automatic system (Sherlock) for quiz generation using linked data and textual descriptions of RDF resources. Sherlock is distinguished from existing quiz generation systems in its generic framework for domain-independent quiz generation as well as in the ability of controlling the difficulty level of the generated quizzes. Difficulty scaling is non-trivial, and it is fundamentally related to cognitive science. We approach the problem with a new angle by perceiving the level of knowledge difficulty as a similarity measure problem and propose a novel hybrid semantic similarity measure using linked data. Extensive experiments show that the proposed semantic similarity measure outperforms four strong baselines with more than 47 % gain in clustering accuracy. In addition, we discovered in the human quiz test that the model accuracy indeed shows a strong correlation with the pairwise quiz similarity.

  19. The Socioculturally Constructed Multivoiced Self as a Framework for Christian Education of Second-Generation Korean American Young Adults

    Science.gov (United States)

    Kang, S. Steve

    2002-01-01

    This article proposes a new framework for theory and practice of Christian education for second-generation Korean American young adults using the literature of sociocultural constructionism and the multivoiced self. This framework can provide holistic nurture and future trajectories in which to encourage a reflexive, praxis-generating faith. The…

  20. Recommendations for institutional policy and network regulatory frameworks towards distributed generation in EU Member States

    International Nuclear Information System (INIS)

    Ten Donkelaar, M.; Van Oostvoorn, F.

    2005-01-01

    Recommendations regarding the development of regulatory frameworks and institutional policies towards an optimal integration of distributed generation (DG) into electricity networks are presented. These recommendations are based on findings from a benchmarking study conducted in the framework of the ENIRDG-net project. The aim of the benchmarking exercise was to identify examples of well-defined pro-DG policies, with clear targets and adequate implementation mechanisms. In this study an adequate pro-DG policy is defined on the basis of a level playing field, a situation where distributed and centralised generation receive equal incentives and have equal access to the liberalised markets for electricity. The benchmark study includes the results of a similar study conducted in the framework of the SUSTELNET project. When comparing the results a certain discrepancy can be noticed between the actual regulation and policy in a number of countries, the medium to long-term targets and the ideal situation described by the level playing field objective. To overcome this discrepancy, a number of recommendations have been drafted for future policy and regulation towards distributed generation

  1. Characterisation of a new bioadhesive system based on polysaccharides with the potential to be used as bone glue.

    Science.gov (United States)

    Hoffmann, Bettina; Volkmer, Elias; Kokott, Andreas; Augat, Peter; Ohnmacht, Michael; Sedlmayr, Nicole; Schieker, Matthias; Claes, Lutz; Mutschler, Wolf; Ziegler, Günter

    2009-10-01

    Although gluing bone is in theory a very attractive alternative to classical fracture treatment, this method is not yet clinically established due to the lack of an adhesive which would meet all the necessary requirements. We therefore developed a novel two-component bioadhesive system with the potential to be used as a bone adhesive based on biocompatible and degradable biopolymers (chitosan, oxidised dextran or starch). After mixing in water, the two components covalently cross-link by forming a Schiff's base. By the same mechanism, the glue binds to any other exposed amino group such as for example those exposed in fractured bone, even in the presence of water. Modified chitosan was synthesised from commercially available chitosan by deacetylation and was then reduced in molecular weight by heating in acid. The amount of free amino groups was analysed by IR. The molecular weight was determined by viscosimetry. Starch or dextran were oxidised with periodic acid to generate aldehyde groups, which were quantified by titration. l-Dopa was conjugated to oxidised dextran or starch in analogy to the gluing mechanism of mussels. Biomechanical studies revealed that the new glue is superior to fibrin glue, but has less adhesive strength than cyanoacrylates. In vitro cell testing demonstrated excellent biocompatibility, rendering this glue a potential candidate for clinical use.

  2. Persona Rights for User-Generated Content: A Normative Framework for Privacy and Intellectual Property Regulation

    Directory of Open Access Journals (Sweden)

    Tamara Shepherd

    2012-02-01

    Full Text Available This article introduces the term “persona rights” as a normative conceptual framework for analyzing the language of regulatory debates around privacy and intellectual property online, mainly from a Canadian perspective. In using the concept of persona rights to interrogate and critique the current limitations of regulatory discourses in protecting user rights online, the legal implications of persona rights law are translated into more conceptual terms. As a normative framework, persona rights is shown to be useful in addressing the gaps in regulatory understandings of privacy and intellectual property – particularly in spaces for user-generated content (UGC – and in suggesting how policy might be written to account for user rights to the integrity of identity in commercial UGC platforms.

  3. A Framework for Privacy-preserving Classification of Next-generation PHR data.

    Science.gov (United States)

    Koufi, Vassiliki; Malamateniou, Flora; Prentza, Andriana; Vassilacopoulos, George

    2014-01-01

    Personal Health Records (PHRs), integrated with data from various sources, such as social care data, Electronic Health Record data and genetic information, are envisaged as having a pivotal role in transforming healthcare. These data, lumped under the term 'big data', are usually complex, noisy, heterogeneous, longitudinal and voluminous thus prohibiting their meaningful use by clinicians. Deriving value from these data requires the utilization of innovative data analysis techniques, which, however, may be hindered due to potential security and privacy breaches that may arise from improper release of personal health information. This paper presents a HIPAA-compliant machine learning framework that enables privacy-preserving classification of next-generation PHR data. The predictive models acquired can act as supporting tools to clinical practice by enabling more effective prevention, diagnosis and treatment of new incidents. The proposed framework has a huge potential for complementing medical staff expertise as it outperforms the manual inspection of PHR data while protecting patient privacy.

  4. Comparative Study of Neural Network Frameworks for the Next Generation of Adaptive Optics Systems.

    Science.gov (United States)

    González-Gutiérrez, Carlos; Santos, Jesús Daniel; Martínez-Zarzuela, Mario; Basden, Alistair G; Osborn, James; Díaz-Pernas, Francisco Javier; De Cos Juez, Francisco Javier

    2017-06-02

    Many of the next generation of adaptive optics systems on large and extremely large telescopes require tomographic techniques in order to correct for atmospheric turbulence over a large field of view. Multi-object adaptive optics is one such technique. In this paper, different implementations of a tomographic reconstructor based on a machine learning architecture named "CARMEN" are presented. Basic concepts of adaptive optics are introduced first, with a short explanation of three different control systems used on real telescopes and the sensors utilised. The operation of the reconstructor, along with the three neural network frameworks used, and the developed CUDA code are detailed. Changes to the size of the reconstructor influence the training and execution time of the neural network. The native CUDA code turns out to be the best choice for all the systems, although some of the other frameworks offer good performance under certain circumstances.

  5. An IP Framework for the Crew Pairing Problem Using Subsequence Generation

    DEFF Research Database (Denmark)

    Rasmussen, Matias Sevel; Lusby, Richard Martin; Ryan, David

    In this paper we consider an important problem for the airline industry. The widely studied crew pairing problem is typically formulated as a set partitioning problem and solved using the branch-and-price methodology. Here we develop a new integer programming framework, based on the concept...... of subsequence generation, for solving the set partitioning formulation. In subsequence generation one restricts the number of permitted subsequent flights, that a crew member can turn to after completing any particular flight. By restricting the number of subsequences, the number of pairings in the problem...... decreases. The aim is then to dynamically add attractive subsequences to the problem, thereby increasing the number of possible pairings and improving the solution quality. Encouraging results are obtained on 19 real-life instances supplied by Air New Zealand and show that the described methodology...

  6. Statistical framework for detection of genetically modified organisms based on Next Generation Sequencing.

    Science.gov (United States)

    Willems, Sander; Fraiture, Marie-Alice; Deforce, Dieter; De Keersmaecker, Sigrid C J; De Loose, Marc; Ruttink, Tom; Herman, Philippe; Van Nieuwerburgh, Filip; Roosens, Nancy

    2016-02-01

    Because the number and diversity of genetically modified (GM) crops has significantly increased, their analysis based on real-time PCR (qPCR) methods is becoming increasingly complex and laborious. While several pioneers already investigated Next Generation Sequencing (NGS) as an alternative to qPCR, its practical use has not been assessed for routine analysis. In this study a statistical framework was developed to predict the number of NGS reads needed to detect transgene sequences, to prove their integration into the host genome and to identify the specific transgene event in a sample with known composition. This framework was validated by applying it to experimental data from food matrices composed of pure GM rice, processed GM rice (noodles) or a 10% GM/non-GM rice mixture, revealing some influential factors. Finally, feasibility of NGS for routine analysis of GM crops was investigated by applying the framework to samples commonly encountered in routine analysis of GM crops. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. Generation of political priority for global health initiatives: a framework and case study of maternal mortality.

    Science.gov (United States)

    Shiffman, Jeremy; Smith, Stephanie

    2007-10-13

    Why do some global health initiatives receive priority from international and national political leaders whereas others receive little attention? To analyse this question we propose a framework consisting of four categories: the strength of the actors involved in the initiative, the power of the ideas they use to portray the issue, the nature of the political contexts in which they operate, and characteristics of the issue itself. We apply this framework to the case of a global initiative to reduce maternal mortality, which was launched in 1987. We undertook archival research and interviewed people connected with the initiative, using a process-tracing method that is commonly employed in qualitative research. We report that despite two decades of effort the initiative remains in an early phase of development, hampered by difficulties in all these categories. However, the initiative's 20th year, 2007, presents opportunities to build political momentum. To generate political priority, advocates will need to address several challenges, including the creation of effective institutions to guide the initiative and the development of a public positioning of the issue to convince political leaders to act. We use the framework and case study to suggest areas for future research on the determinants of political priority for global health initiatives, which is a subject that has attracted much speculation but little scholarship.

  8. Information-provider scripts for GLUE2 and RAID configurations.

    CERN Document Server

    Kalimeris, Dimitrios

    2014-01-01

    This report will outline two projects that were done as part of a three months long summer internship at CERN. In the first project we dealt with Worldwide LHC Computing Grid (WLCG) and its information system. The information system currently conforms to a schema called GLUE and it is evolving towards a new version: GLUE2. The aim of the project was to develop and adapt the current information system of the WLCG, used by the Large Scale Storage Systems at CERN (CASTOR and EOS), to the new GLUE2 schema. During the second project we investigated different RAID configurations so that we can get performance boost from CERN's disk systems in the future. RAID 1 that is currently in use is not an option anymore because of limited performance and high cost. We tried to discover RAID configurations that will improve the performance and simultaneously decrease the cost.

  9. Using the living laboratory framework as a basis for understanding next-generation analyst work

    Science.gov (United States)

    McNeese, Michael D.; Mancuso, Vincent; McNeese, Nathan; Endsley, Tristan; Forster, Pete

    2013-05-01

    The preparation of next generation analyst work requires alternative levels of understanding and new methodological departures from the way current work transpires. Current work practices typically do not provide a comprehensive approach that emphasizes the role of and interplay between (a) cognition, (b) emergent activities in a shared situated context, and (c) collaborative teamwork. In turn, effective and efficient problem solving fails to take place, and practice is often composed of piecemeal, techno-centric tools that isolate analysts by providing rigid, limited levels of understanding of situation awareness. This coupled with the fact that many analyst activities are classified produces a challenging situation for researching such phenomena and designing and evaluating systems to support analyst cognition and teamwork. Through our work with cyber, image, and intelligence analysts we have realized that there is more required of researchers to study human-centered designs to provide for analyst's needs in a timely fashion. This paper identifies and describes how The Living Laboratory Framework can be utilized as a means to develop a comprehensive, human-centric, and problem-focused approach to next generation analyst work, design, and training. We explain how the framework is utilized for specific cases in various applied settings (e.g., crisis management analysis, image analysis, and cyber analysis) to demonstrate its value and power in addressing an area of utmost importance to our national security. Attributes of analyst work settings are delineated to suggest potential design affordances that could help improve cognitive activities and awareness. Finally, the paper puts forth a research agenda for the use of the framework for future work that will move the analyst profession in a viable manner to address the concerns identified.

  10. Generation of multipartite entangled states for chains of atoms in the framework of cavity-QED

    Energy Technology Data Exchange (ETDEWEB)

    Gonta, Denis

    2010-07-07

    Cavity quantum electrodynamics is a research field that studies electromagnetic fields in confined spaces and the radiative properties of atoms in such fields. Experimentally, the simplest example of such system is a single atom interacting with modes of a high-finesse resonator. Theoretically, such system bears an excellent framework for quantum information processing in which atoms and light are interpreted as bits of quantum information and their mutual interaction provides a controllable entanglement mechanism. In this thesis, we present several practical schemes for generation of multipartite entangled states for chains of atoms which pass through one or more high-finesse resonators. In the first step, we propose two schemes for generation of one- and two-dimensional cluster states of arbitrary size. These schemes are based on the resonant interaction of a chain of Rydberg atoms with one or more microwave cavities. In the second step, we propose a scheme for generation of multipartite W states. This scheme is based on the off-resonant interaction of a chain of three-level atoms with an optical cavity and a laser beam. We describe in details all the individual steps which are required to realize the proposed schemes and, moreover, we discuss several techniques to reveal the non-classical correlations associated with generated small-sized entangled states. (orig.)

  11. A Systems Engineering Framework for Design, Construction and Operation of the Next Generation Nuclear Plant

    International Nuclear Information System (INIS)

    Edward J. Gorski; Charles V. Park; Finis H. Southworth

    2004-01-01

    Not since the International Space Station has a project of such wide participation been proposed for the United States. Ten countries, the European Union, universities, Department of Energy (DOE) laboratories, and industry will participate in the research and development, design, construction and/or operation of the fourth generation of nuclear power plants with a demonstration reactor to be built at a DOE site and operational by the middle of the next decade. This reactor will be like no other. The Next Generation Nuclear Plant (NGNP) will be passively safe, economical, highly efficient, modular, proliferation resistant, and sustainable. In addition to electrical generation, the NGNP will demonstrate efficient and cost effective generation of hydrogen to support the President's Hydrogen Initiative. To effectively manage this multi-organizational and technologically complex project, systems engineering techniques and processes will be used extensively to ensure delivery of the final product. The technological and organizational challenges are complex. Research and development activities are required, material standards require development, hydrogen production, storage and infrastructure requirements are not well developed, and the Nuclear Regulatory Commission may further define risk-informed/performance-based approach to licensing. Detailed design and development will be challenged by the vast cultural and institutional differences across the participants. Systems engineering processes must bring the technological and organizational complexity together to ensure successful product delivery. This paper will define the framework for application of systems engineering to this $1.5B - $1.9B project

  12. Measurement framework for product service system performance of generator set distributors

    Science.gov (United States)

    Sofianti, Tanika D.

    2017-11-01

    Selling Generator Set (Genset) in B2B market, distributors assisted manufacturers to sell products. This is caused by the limited resources owned by the manufacturer for adding service elements. These service elements are needed to enhance the competitiveness of the generator sets. Some genset distributors often sell products together with supports to their customers. Industrial distributor develops services to meet the needs of the customer. Generator set distributors support machines and equipment produced by manufacturer. The services delivered by the distributors could enhance value obtained by the customers from the equipment. Services provided to customers in bidding process, ordering process of the equipment from the manufacturer, equipment delivery, installations, and the after sales stage. This paper promotes framework to measure Product Service System (PSS) of Generator Set distributors in delivering their products and services for the customers. The methodology of conducting this research is by adopting the perspective of the providers and customers and by taking into account the tangible and intangible products. This research leads to the idea of improvement of current Product Service System of a Genset distributor. This research needs further studies in more detailed measures and the implementation of measurement tools.

  13. Generation of multipartite entangled states for chains of atoms in the framework of cavity-QED

    International Nuclear Information System (INIS)

    Gonta, Denis

    2010-01-01

    Cavity quantum electrodynamics is a research field that studies electromagnetic fields in confined spaces and the radiative properties of atoms in such fields. Experimentally, the simplest example of such system is a single atom interacting with modes of a high-finesse resonator. Theoretically, such system bears an excellent framework for quantum information processing in which atoms and light are interpreted as bits of quantum information and their mutual interaction provides a controllable entanglement mechanism. In this thesis, we present several practical schemes for generation of multipartite entangled states for chains of atoms which pass through one or more high-finesse resonators. In the first step, we propose two schemes for generation of one- and two-dimensional cluster states of arbitrary size. These schemes are based on the resonant interaction of a chain of Rydberg atoms with one or more microwave cavities. In the second step, we propose a scheme for generation of multipartite W states. This scheme is based on the off-resonant interaction of a chain of three-level atoms with an optical cavity and a laser beam. We describe in details all the individual steps which are required to realize the proposed schemes and, moreover, we discuss several techniques to reveal the non-classical correlations associated with generated small-sized entangled states. (orig.)

  14. A Framework for Evaluation of Safety and Generation Effect of Investment Considering Life Cycle Management in Nuclear Power Plants

    International Nuclear Information System (INIS)

    Yang, Hui Chang; Kim, Joon Hyun; Ahn, Nam Sung

    2006-01-01

    Along with the increasing pressure to enhance generation availability with low cost or investment, regulatory organization has been focused on the enhancement of safety in performance-based and risk informed regulation framework. Considering this, the most cost-beneficial solution should be found among the short-term and long-term investment plans. The objective of this research is to propose a generalized framework to evaluate safety and generation effect of investment plan for equipment in nuclear power plants

  15. Caged Molecular Glues as Photoactivatable Tags for Nuclear Translocation of Guests in Living Cells.

    Science.gov (United States)

    Arisaka, Akio; Mogaki, Rina; Okuro, Kou; Aida, Takuzo

    2018-02-21

    We developed dendritic caged molecular glues ( Caged Glue-R) as tags for nucleus-targeted drug delivery, whose multiple guanidinium ion (Gu + ) pendants are protected by an anionic photocleavable unit (butyrate-substituted nitroveratryloxycarbonyl; BA NVOC). Negatively charged Caged Glue-R hardly binds to anionic biomolecules because of their electrostatic repulsion. However, upon exposure of Caged Glue-R to UV light or near-infrared (NIR) light, the BA NVOC groups of Caged Glue-R are rapidly detached to yield an uncaged molecular glue ( Uncaged Glue-R) that carries multiple Gu + pendants. Because Gu + forms a salt bridge with PO 4 - , Uncaged Glue-R tightly adheres to anionic biomolecules such as DNA and phospholipids in cell membranes by a multivalent salt-bridge formation. When tagged with Caged Glue-R, guests can be taken up into living cells via endocytosis and hide in endosomes. However, when the Caged Glue-R tag is photochemically uncaged to form Uncaged Glue-R, the guests escape from the endosome and migrate into the cytoplasm followed by the cell nucleus. We demonstrated that quantum dots (QDs) tagged with Caged Glue-R can be delivered efficiently to cell nuclei eventually by irradiation with light.

  16. A framework for smartphone-enabled, patient-generated health data analysis

    Directory of Open Access Journals (Sweden)

    Shreya S. Gollamudi

    2016-08-01

    Full Text Available Background: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously conducted a six-month interventional trial examining the efficacy of a comprehensive smartphone-based health monitoring program for individuals with chronic disease. This included 38 individuals with hypertension who recorded 6,290 blood pressure readings over the trial. Methods: In the present study, we provide a hypothesis testing framework for unstructured time series data, typical of patient-generated mobile device data. We used a mixed model approach for unequally spaced repeated measures using autoregressive and generalized autoregressive models, and applied this to the blood pressure data generated in this trial. Results: We were able to detect, roughly, a 2 mmHg decrease in both systolic and diastolic blood pressure over the course of the trial despite considerable intra- and inter-individual variation. Furthermore, by supplementing this finding by using a sequential analysis approach, we observed this result over three months prior to the official study end—highlighting the effectiveness of leveraging the digital nature of this data source to form timely conclusions. Conclusions: Health data generated through the use of smartphones and other mobile devices allow individuals the opportunity to make informed health decisions, and provide researchers the opportunity to address innovative health and biology questions. The hypothesis testing framework we present can be applied in future studies utilizing digital medicine technology or implemented in the technology itself to support the quantified self.

  17. Learning Physics-based Models in Hydrology under the Framework of Generative Adversarial Networks

    Science.gov (United States)

    Karpatne, A.; Kumar, V.

    2017-12-01

    Generative adversarial networks (GANs), that have been highly successful in a number of applications involving large volumes of labeled and unlabeled data such as computer vision, offer huge potential for modeling the dynamics of physical processes that have been traditionally studied using simulations of physics-based models. While conventional physics-based models use labeled samples of input/output variables for model calibration (estimating the right parametric forms of relationships between variables) or data assimilation (identifying the most likely sequence of system states in dynamical systems), there is a greater opportunity to explore the full power of machine learning (ML) methods (e.g, GANs) for studying physical processes currently suffering from large knowledge gaps, e.g. ground-water flow. However, success in this endeavor requires a principled way of combining the strengths of ML methods with physics-based numerical models that are founded on a wealth of scientific knowledge. This is especially important in scientific domains like hydrology where the number of data samples is small (relative to Internet-scale applications such as image recognition where machine learning methods has found great success), and the physical relationships are complex (high-dimensional) and non-stationary. We will present a series of methods for guiding the learning of GANs using physics-based models, e.g., by using the outputs of physics-based models as input data to the generator-learner framework, and by using physics-based models as generators trained using validation data in the adversarial learning framework. These methods are being developed under the broad paradigm of theory-guided data science that we are developing to integrate scientific knowledge with data science methods for accelerating scientific discovery.

  18. Second generation CO2 FEP analysis: Cassifcarbon sequestration scenario identification framework

    NARCIS (Netherlands)

    Yavuz, F.T.; Tilburg, T. van; Pagnier, H.

    2008-01-01

    A novel scenario analysis framework has been created, called Carbon Sequestration Scenario Identification Framework (CASSIF). This framework addresses containment performance defined by the three major categories: well, fault and seal integrity. The relevant factors that influence the integrity are

  19. A distributed big data storage and data mining framework for solar-generated electricity quantity forecasting

    Science.gov (United States)

    Wang, Jianzong; Chen, Yanjun; Hua, Rui; Wang, Peng; Fu, Jia

    2012-02-01

    Photovoltaic is a method of generating electrical power by converting solar radiation into direct current electricity using semiconductors that exhibit the photovoltaic effect. Photovoltaic power generation employs solar panels composed of a number of solar cells containing a photovoltaic material. Due to the growing demand for renewable energy sources, the manufacturing of solar cells and photovoltaic arrays has advanced considerably in recent years. Solar photovoltaics are growing rapidly, albeit from a small base, to a total global capacity of 40,000 MW at the end of 2010. More than 100 countries use solar photovoltaics. Driven by advances in technology and increases in manufacturing scale and sophistication, the cost of photovoltaic has declined steadily since the first solar cells were manufactured. Net metering and financial incentives, such as preferential feed-in tariffs for solar-generated electricity; have supported solar photovoltaics installations in many countries. However, the power that generated by solar photovoltaics is affected by the weather and other natural factors dramatically. To predict the photovoltaic energy accurately is of importance for the entire power intelligent dispatch in order to reduce the energy dissipation and maintain the security of power grid. In this paper, we have proposed a big data system--the Solar Photovoltaic Power Forecasting System, called SPPFS to calculate and predict the power according the real-time conditions. In this system, we utilized the distributed mixed database to speed up the rate of collecting, storing and analysis the meteorological data. In order to improve the accuracy of power prediction, the given neural network algorithm has been imported into SPPFS.By adopting abundant experiments, we shows that the framework can provide higher forecast accuracy-error rate less than 15% and obtain low latency of computing by deploying the mixed distributed database architecture for solar-generated electricity.

  20. Environmental implications of electricity generation in an integrated long-term planning framework

    International Nuclear Information System (INIS)

    Turner, Graham M.; West, James

    2012-01-01

    Long-term, integrated modelling of electricity generation capacity and its operational requirements is important for coherent energy policy because of the multi-decadal lifespan of such plant, and because related fuel requirements, water consumption, and greenhouse gas emissions impact other sectors. This paper describes a physical model of electricity generation designed for long-term simulations, including the reproduction of decades of historical data, and its application to key policy questions. The simulation uses a dynamic, physical input–output model for the basic material and energy industries, embedded in an economy-wide stocks and flows framework (SFF). The historical reproduction, illustrated for the state of Victoria, is based on integrating bottom-up technical data on physical processes as inputs, and validating output against top-down aggregate data. We show that while greenhouse gas emissions would decrease significantly with the aggressive introduction of cleaner generation technology, long-term reductions are difficult to maintain against ongoing growth in consumption. Additionally, our sensitivity analysis identifies the importance of rapid action due to the age structure of operating power stations. We also identify significant imposts of alternative power generation on land and water resources, though a business-as-usual scenario would impose greater losses of water resources. - Highlights: ► System-wide dynamic analysis is needed to avoid unintended adverse environmental outcomes. ► Dynamics of long-lived plant is important in transitions for reducing greenhouse gas emissions. ► Large gains in GHG emissions efficiency of generation portfolios fail to maintain low emissions.

  1. Risk management frameworks: supporting the next generation of Murray-Darling Basin water sharing plans

    Directory of Open Access Journals (Sweden)

    G. M. Podger

    2014-09-01

    Full Text Available Water jurisdictions in Australia are required to prepare and implement water resource plans. In developing these plans the common goal is realising the best possible use of the water resources – maximising outcomes while minimising negative impacts. This requires managing the risks associated with assessing and balancing cultural, industrial, agricultural, social and environmental demands for water within a competitive and resource-limited environment. Recognising this, conformance to international risk management principles (ISO 31000:2009 have been embedded within the Murray-Darling Basin Plan. Yet, to date, there has been little strategic investment by water jurisdictions in bridging the gap between principle and practice. The ISO 31000 principles and the risk management framework that embodies them align well with an adaptive management paradigm within which to conduct water resource planning. They also provide an integrative framework for the development of workflows that link risk analysis with risk evaluation and mitigation (adaptation scenarios, providing a transparent, repeatable and robust platform. This study, through a demonstration use case and a series of workflows, demonstrates to policy makers how these principles can be used to support the development of the next generation of water sharing plans in 2019. The workflows consider the uncertainty associated with climate and flow inputs, and model parameters on irrigation and hydropower production, meeting environmental flow objectives and recreational use of the water resource. The results provide insights to the risks associated with meeting a range of different objectives.

  2. Tests of optical glues for the PANDA electromagnetic calorimeter

    NARCIS (Netherlands)

    Dbeyssi, A.; Tomasi-Gustafsson, E.; Hennino, T.; Imre, M.; Kunne, R.; Le Galliard, C.; Marchand, D.; Maroni, A.; Ramstein, B.; Rosier, P.; Bremer, D.; Dormenev, V.; Eissner, T.; Kuske, T.; Novotny, R.; Moeini, H.; Bondarenko, O.; Kavatsyuk, M.; Loehner, H.; Messchendorp, G.; Tambave, G.

    2013-01-01

    This paper reports on the results of tests for low temperature applications of two commercial optical glues in the electromagnetic calorimeter of PANDA at FAIR. Mechanical, thermal and optical properties are presented, as well as radiation hardness to photon and proton radiation. (C) 2013 Elsevier

  3. Effectiveness of Fibrin Glue in Adherence of Skin Graft.

    Science.gov (United States)

    Reddy, Konda Sireesha; Chittoria, Ravi Kumar; Babu, Preethitha; Marimuthu, Senthil Kumaran; Kumar, Sudhanva Hemanth; Subbarayan, Elan Kumar; Chavan, Vinayak; Mohapatra, Devi Prasad; Sivakumar, Dinesh Kumar; Friji, M T

    2017-01-01

    Graft fixation is important for graft take. Fibrin glue has been proposed as an ideal material, because of its human origin and it provides firm adhesion in seconds or minutes. To evaluate the efficiency of fibrin glue, in increasing the take of skin graft. Assessment includes surgical time taken for graft fixation, haematoma/seroma formation, engraftment and wound closure by day 14. The study is an observational prospective study conducted in the Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, from January 2016 to June 2016. Sixteen patients who underwent split skin grafting were assessed during the study period. Fibrin glue was used on the recipient bed before grafting. Better haemostasis and graft adhesion, with a significant reduction of surgical time, were noted. The safety profile of fibrin glue was excellent as indicated by the lack of any related serious adverse experiences. These findings demonstrate that it is safe and effective for attachment of skin grafts, with outcomes at least as good as conventional methods.

  4. Contribution of glue layer into epidermis sample fluorescence dynamics

    Science.gov (United States)

    Salomatina, Elena V.; Chernova, Svetlana P.; Pravdin, Alexander B.

    2000-04-01

    In this work, the temporal behavior of autofluorescence of epidermis samples under UV-irradiation has ben studied. The samples were prepared using surface epidermis stripping technique. Fluorescence spectra and kinetic curves of fluorescence intensity have been obtained. It has been concluded that the glue composition used allows the measurement of epidermis fluorescence dynamics with the first 60 min of experiment.

  5. Gravity: The Glue of the Universe. History and Activities.

    Science.gov (United States)

    Gilbert, Harry; Smith, Diana Gilbert

    This book presents a story of the history of gravity, the glue of the universe, and is based on two premises: (1) an understanding of mathematics is not required to grasp the concepts and implications of relativity; and (2) relativity has altered forever the perceptions of gravity, space, time, and how the universe works. A narrative text section…

  6. nQuire: a statistical framework for ploidy estimation using next generation sequencing.

    Science.gov (United States)

    Weiß, Clemens L; Pais, Marina; Cano, Liliana M; Kamoun, Sophien; Burbano, Hernán A

    2018-04-04

    Intraspecific variation in ploidy occurs in a wide range of species including pathogenic and nonpathogenic eukaryotes such as yeasts and oomycetes. Ploidy can be inferred indirectly - without measuring DNA content - from experiments using next-generation sequencing (NGS). We present nQuire, a statistical framework that distinguishes between diploids, triploids and tetraploids using NGS. The command-line tool models the distribution of base frequencies at variable sites using a Gaussian Mixture Model, and uses maximum likelihood to select the most plausible ploidy model. nQuire handles large genomes at high coverage efficiently and uses standard input file formats. We demonstrate the utility of nQuire analyzing individual samples of the pathogenic oomycete Phytophthora infestans and the Baker's yeast Saccharomyces cerevisiae. Using these organisms we show the dependence between reliability of the ploidy assignment and sequencing depth. Additionally, we employ normalized maximized log- likelihoods generated by nQuire to ascertain ploidy level in a population of samples with ploidy heterogeneity. Using these normalized values we cluster samples in three dimensions using multivariate Gaussian mixtures. The cluster assignments retrieved from a S. cerevisiae population recovered the true ploidy level in over 96% of samples. Finally, we show that nQuire can be used regionally to identify chromosomal aneuploidies. nQuire provides a statistical framework to study organisms with intraspecific variation in ploidy. nQuire is likely to be useful in epidemiological studies of pathogens, artificial selection experiments, and for historical or ancient samples where intact nuclei are not preserved. It is implemented as a stand-alone Linux command line tool in the C programming language and is available at https://github.com/clwgg/nQuire under the MIT license.

  7. Development of a framework for the neutorinics analysis system for next generation (2) (Contract research)

    International Nuclear Information System (INIS)

    Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro; Jin, Tomoyuki; Yokoyama, Kenji

    2008-10-01

    Japan Atomic Energy Agency promotes development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of prototype reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation system provides solutions to the following requirements: (1) Flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative assurance of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality assurance and development efficiency. There has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. In order to solve this problem, a policy of the hybrid system is adopted for the next-generation system, in which a controlling part is implemented in the scripting language with rich flexibility and maintainability and solution kernels that requires execution speed in the system language. In this study, detailed design of a framework, its implementation and tests are conducted so that a Python system layer can drive calculation codes written in C++ and/or Fortran. It is confirmed that various type of calculation codes such as diffusion, transport and burnup codes can be treated in the same manner on the platform for unified management system for calculation codes with a data exchange mechanism for abstracted data model between the Python and the calculation code layers. (author)

  8. Informal uncertainty analysis (GLUE) of continuous flow simulation in a hybrid sewer system with infiltration inflow - Consistency of containment ratios in calibration and validation?

    DEFF Research Database (Denmark)

    Breinholt, Anders; Grum, Morten; Madsen, Henrik

    2013-01-01

    to assess parameter and flow simulation uncertainty using a simplified lumped sewer model that accounts for three separate flow contributions: wastewater, fast runoff from paved areas, and slow infiltrating water from permeable areas. Recently GLUE methodology has been critisised for generating prediction...... rain inputs and more accurate flow observations to reduce parameter and model simulation uncertainty. © Author(s) 2013....

  9. Development of a framework for the neutronics analysis system for next generation (3)

    International Nuclear Information System (INIS)

    Yokoyama, Kenji; Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro

    2010-02-01

    Development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems is in progress. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of commercial reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation analysis system provides solutions to the following requirements: (1) flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative proof of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality management and development efficiency. The next-generation analysis system supports many fields, such as thermal-hydraulic analysis, structure analysis, reactor physics etc., and now we are studying reactor physics analysis system for fast reactor in advance. As for reactor physics analysis methods for fast reactor, we have established the JUPITER standard analysis methods based on the past study. But, there has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. That is why, we have developed the next-generation analysis system for reactor physics which reproduces the JUPITER standard analysis method that has been developed so far and newly realizes burnup and design analysis for fast reactor and functions for cross section adjustment. In the present study, we examined in detail the existing design and implementation of ZPPR critical experiment analysis database followed by unification of models within the framework of the next-generation analysis system by

  10. A framework for distributed mixed-language scientific applications

    International Nuclear Information System (INIS)

    Quarrie, D.R.

    1996-01-01

    The Object Management Group has defined an architecture (COBRA) for distributed object applications based on an Object Broker and Interface Definition Language. This project builds upon this architecture to establish a framework for the creation of mixed language scientific applications. A prototype compiler has been written that generates FORTRAN 90 or Eiffel subs and skeletons and the required C++ glue code from an input IDL file that specifies object interfaces. This generated code can be used directly for non-distributed mixed language applications or in conjunction with the C++ code generated from a commercial IDL compiler for distributed applications. A feasibility study is presently to see whether a fully integrated software development environment for distributed, mixed-language applications can be created by modifying the back-end code generator of a commercial CASE tool to emit IDL. (author)

  11. Glue versus suture for mesh fixation in inguinal hernia repair.

    Science.gov (United States)

    Chandrasekar, Shruthi; Jeyakumar, S; Ganapathy, Tharun

    2018-03-22

    Inguinal hernia is one of the most common surgical problem presenting to the surgical OPD. Surgery is the mainstay of treatment for inguinal hernia today. Surgery for inguinal hernia has undergone a great evolution over a period of several centuries. Lichenstein's tension free hernioplasty is the one of the first surgeries taught to a surgical resident. The main aim of surgeries in this era is to give the best possible results with the least possible pain, scar and time. This has given rise to so many modifications to the classical Lichenstein's procedure and also to laparoscopic hernioplasty. Pain after inguinal hernia surgery is found to be debilitating and altering the quality of life in several patients, which has been attributed to the traumatic fixation of the mesh with sutures. This has paved way to the development of various atraumatic methods of fixation, tissue glue is one such development. Hence this study, to compare traumatic and atraumatic methods of mesh fixation in inguinal hernia repair. The aim of this study was to compare suture fixation versus tissue glue fixation of the mesh in inguinal hernia repair. Primary objective was to compare the immediate and chronic post-operative pain. Secondary objective was to compare the time taken for the procedure by the two methods in use and also to compare the presence of any complications. and methodology: This study was done in the General Surgery department of XXX hospital, medical college and research centre, kattangulathur after Ethics committee clearance. It is a single blinded study. The study was done on 51 patients consenting for the study and meeting the inclusion criterias from the period of March 2016 to August 2017 out of which 26 were selected for glue mesh fixation and 25 for suture mesh fixation according to simple randomization. The suture group patients underwent classical Lichenstein's tension free hernioplasty and the glue group underwent Lichenstein's hernioplasty with glue where dots of

  12. A Framework for the Generation and Dissemination of Drop Size Distribution (DSD) Characteristics Using Multiple Platforms

    Science.gov (United States)

    Wolf, David B.; Tokay, Ali; Petersen, Walt; Williams, Christopher; Gatlin, Patrick; Wingo, Mathew

    2010-01-01

    Proper characterization of the precipitation drop size distribution (DSD) is integral to providing realistic and accurate space- and ground-based precipitation retrievals. Current technology allows for the development of DSD products from a variety of platforms, including disdrometers, vertical profilers and dual-polarization radars. Up to now, however, the dissemination or availability of such products has been limited to individual sites and/or field campaigns, in a variety of formats, often using inconsistent algorithms for computing the integral DSD parameters, such as the median- and mass-weighted drop diameter, total number concentration, liquid water content, rain rate, etc. We propose to develop a framework for the generation and dissemination of DSD characteristic products using a unified structure, capable of handling the myriad collection of disdrometers, profilers, and dual-polarization radar data currently available and to be collected during several upcoming GPM Ground Validation field campaigns. This DSD super-structure paradigm is an adaptation of the radar super-structure developed for NASA s Radar Software Library (RSL) and RSL_in_IDL. The goal is to provide the DSD products in a well-documented format, most likely NetCDF, along with tools to ingest and analyze the products. In so doing, we can develop a robust archive of DSD products from multiple sites and platforms, which should greatly benefit the development and validation of precipitation retrieval algorithms for GPM and other precipitation missions. An outline of this proposed framework will be provided as well as a discussion of the algorithms used to calculate the DSD parameters.

  13. A framework for generating and analyzing movement paths on ecological landscapes.

    Science.gov (United States)

    Getz, Wayne M; Saltz, David

    2008-12-09

    The movement paths of individuals over landscapes are basically represented by sequences of points (x(i), y(i)) occurring at times t(i). Theoretically, these points can be viewed as being generated by stochastic processes that in the simplest cases are Gaussian random walks on featureless landscapes. Generalizations have been made of walks that (i) take place on landscapes with features, (ii) have correlated distributions of velocity and direction of movement in each time interval, (iii) are Lévy processes in which distance or waiting-time (time-between steps) distributions have infinite moments, or (iv) have paths bounded in space and time. We begin by demonstrating that rather mild truncations of fat-tailed step-size distributions have a dramatic effect on dispersion of organisms, where such truncations naturally arise in real walks of organisms bounded by space and, more generally, influenced by the interactions of physiological, behavioral, and ecological factors with landscape features. These generalizations permit not only increased realism and hence greater accuracy in constructing movement pathways, but also provide a biogeographically detailed epistemological framework for interpreting movement patterns in all organisms, whether tossed in the wind or willfully driven. We illustrate the utility of our framework by demonstrating how fission-fusion herding behavior arises among individuals endeavoring to satisfy both nutritional and safety demands in heterogeneous environments. We conclude with a brief discussion of potential methods that can be used to solve the inverse problem of identifying putative causal factors driving movement behavior on known landscapes, leaving details to references in the literature.

  14. Uncertainty assessment of integrated distributed hydrological models using GLUE with Markov chain Monte Carlo sampling

    DEFF Research Database (Denmark)

    Blasone, Roberta-Serena; Madsen, Henrik; Rosbjerg, Dan

    2008-01-01

    uncertainty estimation (GLUE) procedure based on Markov chain Monte Carlo sampling is applied in order to improve the performance of the methodology in estimating parameters and posterior output distributions. The description of the spatial variations of the hydrological processes is accounted for by defining......In recent years, there has been an increase in the application of distributed, physically-based and integrated hydrological models. Many questions regarding how to properly calibrate and validate distributed models and assess the uncertainty of the estimated parameters and the spatially......-site validation must complement the usual time validation. In this study, we develop, through an application, a comprehensive framework for multi-criteria calibration and uncertainty assessment of distributed physically-based, integrated hydrological models. A revised version of the generalized likelihood...

  15. A novel optimal distribution system planning framework implementing distributed generation in a deregulated electricity market

    International Nuclear Information System (INIS)

    Porkar, S.; Poure, P.; Abbaspour-Tehrani-fard, A.; Saadate, S.

    2010-01-01

    This paper introduces a new framework included mathematical model and a new software package interfacing two powerful softwares (MATLAB and GAMS) for obtaining the optimal distributed generation (DG) capacity sizing and sitting investments with capability to simulate large distribution system planning. The proposed optimization model allows minimizing total system planning costs for DG investment, DG operation and maintenance, purchase of power by the distribution companies (DISCOs) from transmission companies (TRANSCOs) and system power losses. The proposed model provides not only the DG size and site but also the new market price as well. Three different cases depending on system conditions and three different scenarios depending on different planning alternatives and electrical market structures, have been considered. They have allowed validating the economical and electrical benefits of introducing DG by solving the distribution system planning problem and by improving power quality of distribution system. DG installation increases the feeders' lifetime by reducing their loading and adds the benefit of using the existing distribution system for further load growth without the need for feeders upgrading. More, by investing in DG, the DISCO can minimize its total planning cost and reduce its customers' bills. (author)

  16. A Unified Framework for Creating Domain Dependent Polarity Lexicons from User Generated Reviews.

    Directory of Open Access Journals (Sweden)

    Muhammad Zubair Asghar

    Full Text Available The exponential increase in the explosion of Web-based user generated reviews has resulted in the emergence of Opinion Mining (OM applications for analyzing the users' opinions toward products, services, and policies. The polarity lexicons often play a pivotal role in the OM, indicating the positivity and negativity of a term along with the numeric score. However, the commonly available domain independent lexicons are not an optimal choice for all of the domains within the OM applications. The aforementioned is due to the fact that the polarity of a term changes from one domain to other and such lexicons do not contain the correct polarity of a term for every domain. In this work, we focus on the problem of adapting a domain dependent polarity lexicon from set of labeled user reviews and domain independent lexicon to propose a unified learning framework based on the information theory concepts that can assign the terms with correct polarity (+ive, -ive scores. The benchmarking on three datasets (car, hotel, and drug reviews shows that our approach improves the performance of the polarity classification by achieving higher accuracy. Moreover, using the derived domain dependent lexicon changed the polarity of terms, and the experimental results show that our approach is more effective than the base line methods.

  17. Framework for generating expert systems to perform computer security risk analysis

    International Nuclear Information System (INIS)

    Smith, S.T.; Lim, J.J.

    1985-01-01

    At Los Alamos we are developing a framework to generate knowledge-based expert systems for performing automated risk analyses upon a subject system. The expert system is a computer program that models experts' knowledge about a topic, including facts, assumptions, insights, and decision rationale. The subject system, defined as the collection of information, procedures, devices, and real property upon which the risk analysis is to be performed, is a member of the class of systems that have three identifying characteristics: a set of desirable assets (or targets), a set of adversaries (or threats) desiring to obtain or to do harm to the assets, and a set of protective mechanisms to safeguard the assets from the adversaries. Risk analysis evaluates both vulnerability to and the impact of successful threats against the targets by determining the overall effectiveness of the subject system safeguards, identifying vulnerabilities in that set of safeguards, and determining cost-effective improvements to the safeguards. As a testbed, we evaluate the inherent vulnerabilities and risks in a system of computer security safeguards. The method considers safeguards protecting four generic targets (physical plant of the computer installation, its hardware, its software, and its documents and displays) against three generic threats (natural hazards, direct human actions requiring the presence of the adversary, and indirect human actions wherein the adversary is not on the premises-perhaps using such access tools as wiretaps, dialup lines, and so forth). Our automated procedure to assess the effectiveness of computer security safeguards differs from traditional risk analysis methods

  18. A novel optimal distribution system planning framework implementing distributed generation in a deregulated electricity market

    Energy Technology Data Exchange (ETDEWEB)

    Porkar, S. [Department of Electrical Engineering, Sharif University of Technology, Tehran (Iran); Groupe de Recherches en Electrotechnique et Electronique de Nancy, GREEN-UHP, Universite Henri Poincare de Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex (France); Poure, P. [Laboratoire d' Instrumentation Electronique de Nancy, LIEN, EA 3440, Universite Henri Poincare de Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex (France); Abbaspour-Tehrani-fard, A. [Department of Electrical Engineering, Sharif University of Technology, Tehran (Iran); Saadate, S. [Groupe de Recherches en Electrotechnique et Electronique de Nancy, GREEN-UHP, Universite Henri Poincare de Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex (France)

    2010-07-15

    This paper introduces a new framework included mathematical model and a new software package interfacing two powerful softwares (MATLAB and GAMS) for obtaining the optimal distributed generation (DG) capacity sizing and sitting investments with capability to simulate large distribution system planning. The proposed optimization model allows minimizing total system planning costs for DG investment, DG operation and maintenance, purchase of power by the distribution companies (DISCOs) from transmission companies (TRANSCOs) and system power losses. The proposed model provides not only the DG size and site but also the new market price as well. Three different cases depending on system conditions and three different scenarios depending on different planning alternatives and electrical market structures, have been considered. They have allowed validating the economical and electrical benefits of introducing DG by solving the distribution system planning problem and by improving power quality of distribution system. DG installation increases the feeders' lifetime by reducing their loading and adds the benefit of using the existing distribution system for further load growth without the need for feeders upgrading. More, by investing in DG, the DISCO can minimize its total planning cost and reduce its customers' bills. (author)

  19. Valuation-Based Framework for Considering Distributed Generation Photovoltaic Tariff Design: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Zinaman, O. R.; Darghouth, N. R.

    2015-02-01

    While an export tariff is only one element of a larger regulatory framework for distributed generation, we choose to focus on tariff design because of the significant impact this program design component has on the various flows of value among power sector stakeholders. In that context, this paper is organized into a series of steps that can be taken during the design of a DGPV export tariff design. To that end this paper outlines a holistic, high-level approach to the complex undertaking of DGPV tariff design, the crux of which is an iterative cost-benefit analysis process. We propose a multi-step progression that aims to promote transparent, focused, and informed dialogue on CBA study methodologies and assumptions. When studies are completed, the long-run marginal avoided cost of the DGPV program should be compared against the costs imposed on utilities and non-participating customers, recognizing that these can be defined differently depending on program objectives. The results of this comparison can then be weighed against other program objectives to formulate tariff options. Potential changes to tariff structures can be iteratively fed back into established analytical tools to inform further discussions.

  20. GeNN: a code generation framework for accelerated brain simulations

    Science.gov (United States)

    Yavuz, Esin; Turner, James; Nowotny, Thomas

    2016-01-01

    Large-scale numerical simulations of detailed brain circuit models are important for identifying hypotheses on brain functions and testing their consistency and plausibility. An ongoing challenge for simulating realistic models is, however, computational speed. In this paper, we present the GeNN (GPU-enhanced Neuronal Networks) framework, which aims to facilitate the use of graphics accelerators for computational models of large-scale neuronal networks to address this challenge. GeNN is an open source library that generates code to accelerate the execution of network simulations on NVIDIA GPUs, through a flexible and extensible interface, which does not require in-depth technical knowledge from the users. We present performance benchmarks showing that 200-fold speedup compared to a single core of a CPU can be achieved for a network of one million conductance based Hodgkin-Huxley neurons but that for other models the speedup can differ. GeNN is available for Linux, Mac OS X and Windows platforms. The source code, user manual, tutorials, Wiki, in-depth example projects and all other related information can be found on the project website http://genn-team.github.io/genn/.

  1. Hydrazine-hydrothermal method to synthesize three-dimensional chalcogenide framework for photocatalytic hydrogen generation

    International Nuclear Information System (INIS)

    Liu Yi; Kanhere, Pushkar D.; Wong, Chui Ling; Tian Yuefeng; Feng Yuhua; Boey, Freddy; Wu, Tom; Chen Hongyu; White, Tim J.; Chen Zhong; Zhang Qichun

    2010-01-01

    A novel chalcogenide, [Mn 2 Sb 2 S 5 (N 2 H 4 ) 3 ] (1), has been synthesized by the hydrazine-hydrothermal method. X-ray crystallography study reveals that the new compound 1 crystallizes in space group P1-bar (no. 2) of the triclinic system. The structure features an open neutral three-dimensional framework, where two-dimensional mesh-like inorganic layers are bridged by intra- and inter-layer hydrazine ligands. Both two Mn1 and Mn2 sites adopt distorted octahedral coordination. While two Sb1 and Sb2 sites exhibit two different coordination geometries, the Sb1 site is coordinated with three S atoms to generate a SbS 3 trigonal-pyramidal geometry, and the Sb2 site adopts a SbS 4 trigonal bipyramidal coordination geometry. It has an optical band gap of about ∼2.09 eV, which was deduced from the diffuse reflectance spectrum, and displays photocatalytic behaviors under visible light irradiation. Magnetic susceptibility measurements show compound 1 obeys the Curie-Weiss law in the range of 50-300 K. -- Graphical abstract: A novel chalcogenide, [Mn 2 Sb 2 S 5 (N 2 H 4 ) 3 ] (1), synthesized by hydrazine-hydrothermal method, has a band gap of about ∼2.09 eV and displays photocatalytic behaviors under visible light irradiation. Display Omitted

  2. Towards GLUE2 evolution of the computing element information model

    CERN Document Server

    Andreozzi, S; Field, L; Kónya, B

    2008-01-01

    A key advantage of Grid systems is the ability to share heterogeneous resources and services between traditional administrative and organizational domains. This ability enables virtual pools of resources to be created and assigned to groups of users. Resource awareness, the capability of users or user agents to have knowledge about the existence and state of resources, is required in order utilize the resource. This awareness requires a description of the services and resources typically defined via a community-agreed information model. One of the most popular information models, used by a number of Grid infrastructures, is the GLUE Schema, which provides a common language for describing Grid resources. Other approaches exist, however they follow different modeling strategies. The presence of different flavors of information models for Grid resources is a barrier for enabling inter-Grid interoperability. In order to solve this problem, the GLUE Working Group in the context of the Open Grid Forum was started. ...

  3. Glasses, Coatings, Glues and Gamma-ray Irradiation

    International Nuclear Information System (INIS)

    Barcala, J.M.; Fernandez, M. G.; Ferrando, A.; Fuentes, J.; Josa, M. I.; Molinero, A.; Oller, J. C.; Arce, P.; Calvo, E.; Figueroa, C. F.; Rodrigo, T.; Vila, I.; Virto, A. L.; Beigveder, J. M.; Genova, I.; Perez, G.; Ruiz, J. A.

    2001-01-01

    Most of the alignment systems for LHC experiments use optomechanical elements confirming a network of points that are monitored by laser beams. LHC experiments, working at the expected nominal luminosity, will induce an extremely high irradiation. basic components such as glasses, coatings and glues may change and their performance may degrade significantly. We have tested various components and identified some of them that can stand 10 years of LHC operation. (Author) 11 refs

  4. Glasses, Coatings, Glues and Gamma-ray Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Barcala, J.M.; Fernandez, M. G.; Ferrando, A.; Fuentes, J.; Josa, M. I.; Molinero, A.; Oller, J. C. [Ciemat. Madrid (Spain); Arce, P.; Calvo, E.; Figueroa, C. F.; Rodrigo, T.; Vila, I.; Virto, A. L. [Universidad de Cantabria. Santander (Spain); Beigveder, J. M.; Genova, I.; Perez, G.; Ruiz, J. A. [CIDA. Madrid (Spain)

    2001-07-01

    Most of the alignment systems for LHC experiments use optomechanical elements confirming a network of points that are monitored by laser beams. LHC experiments, working at the expected nominal luminosity, will induce an extremely high irradiation. basic components such as glasses, coatings and glues may change and their performance may degrade significantly. We have tested various components and identified some of them that can stand 10 years of LHC operation. (Author) 11 refs.

  5. Towards GLUE 2: evolution of the computing element information model

    International Nuclear Information System (INIS)

    Andreozzi, S; Burke, S; Field, L; Konya, B

    2008-01-01

    A key advantage of Grid systems is the ability to share heterogeneous resources and services between traditional administrative and organizational domains. This ability enables virtual pools of resources to be created and assigned to groups of users. Resource awareness, the capability of users or user agents to have knowledge about the existence and state of resources, is required in order utilize the resource. This awareness requires a description of the services and resources typically defined via a community-agreed information model. One of the most popular information models, used by a number of Grid infrastructures, is the GLUE Schema, which provides a common language for describing Grid resources. Other approaches exist, however they follow different modeling strategies. The presence of different flavors of information models for Grid resources is a barrier for enabling inter-Grid interoperability. In order to solve this problem, the GLUE Working Group in the context of the Open Grid Forum was started. The purpose of the group is to oversee a major redesign of the GLUE Schema which should consider the successful modeling choices and flaws that have emerged from practical experience and modeling choices from other initiatives. In this paper, we present the status of the new model for describing computing resources as the first output from the working group with the aim of dissemination and soliciting feedback from the community

  6. Use of Glubran 2 acrylic glue in interventional neuroradiology

    International Nuclear Information System (INIS)

    Raffi, L.; Simonetti, L.; Cenni, P.; Leonardi, M.

    2007-01-01

    Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease. We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel. There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization. The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use. (orig.)

  7. Optimal Management of DoD Lands for Military Training, Ecosystem Services, and Renewable Energy Generation: Framework and Data Requirements

    Science.gov (United States)

    2013-01-01

    published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/ client /default. Base Facilities Environmental Quality ERDC/CERL TR...generation—on the primary land-management driver, the military training. 1.3 Approach The modeling framework was developed to generate a Pareto

  8. Research on preparation of phosphate-modified animal glue binder for foundry use

    Science.gov (United States)

    Wang, Tian-Shu; Liu, Wei-Hua; Li, Ying-Min

    2018-03-01

    In this paper, three phosphates were used as modifiers to modify animal glue binder. The structural characteristics and thermal properties of animal glue binder treated with phosphates were studied by Fourier transform-infrared spectroscopy, gel permeation chromatography and derivative thermogravimetric analysis. The results showed that the modified animal glue binder had better sand tensile strength and lower viscosity than untreated animal glue binder. The best modification process was as follows: the optimal amount of sodium carbonate was 4 wt% to animal glue; the optimal weight ratio of the modifiers was sodium pyrophosphate : sodium tripolyphosphate : sodium hexametaphosphate : animal glue = 3 : 3 : 4 : 100, and the optimal reaction should be performed at 80°C for a reaction time of 120 min. A final tensile strength of approximately 3.20 MPa was achieved and the viscosity value was approximately 880 mPa s.

  9. A Reasoning And Hypothesis-Generation Framework Based On Scalable Graph Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Sukumar, Sreenivas Rangan [ORNL

    2016-01-01

    Finding actionable insights from data has always been difficult. As the scale and forms of data increase tremendously, the task of finding value becomes even more challenging. Data scientists at Oak Ridge National Laboratory are leveraging unique leadership infrastructure (e.g. Urika-XA and Urika-GD appliances) to develop scalable algorithms for semantic, logical and statistical reasoning with unstructured Big Data. We present the deployment of such a framework called ORiGAMI (Oak Ridge Graph Analytics for Medical Innovations) on the National Library of Medicine s SEMANTIC Medline (archive of medical knowledge since 1994). Medline contains over 70 million knowledge nuggets published in 23.5 million papers in medical literature with thousands more added daily. ORiGAMI is available as an open-science medical hypothesis generation tool - both as a web-service and an application programming interface (API) at http://hypothesis.ornl.gov . Since becoming an online service, ORIGAMI has enabled clinical subject-matter experts to: (i) discover the relationship between beta-blocker treatment and diabetic retinopathy; (ii) hypothesize that xylene is an environmental cancer-causing carcinogen and (iii) aid doctors with diagnosis of challenging cases when rare diseases manifest with common symptoms. In 2015, ORiGAMI was featured in the Historical Clinical Pathological Conference in Baltimore as a demonstration of artificial intelligence to medicine, IEEE/ACM Supercomputing and recognized as a Centennial Showcase Exhibit at the Radiological Society of North America (RSNA) Conference in Chicago. The final paper will describe the workflow built for the Cray Urika-XA and Urika-GD appliances that is able to reason with the knowledge of every published medical paper every time a clinical researcher uses the tool.

  10. Compounds from silicones alter enzyme activity in curing barnacle glue and model enzymes.

    Science.gov (United States)

    Rittschof, Daniel; Orihuela, Beatriz; Harder, Tilmann; Stafslien, Shane; Chisholm, Bret; Dickinson, Gary H

    2011-02-17

    Attachment strength of fouling organisms on silicone coatings is low. We hypothesized that low attachment strength on silicones is, in part, due to the interaction of surface available components with natural glues. Components could alter curing of glues through bulk changes or specifically through altered enzyme activity. GC-MS analysis of silicone coatings showed surface-available siloxanes when the coatings were gently rubbed with a cotton swab for 15 seconds or given a 30 second rinse with methanol. Mixtures of compounds were found on 2 commercial and 8 model silicone coatings. The hypothesis that silicone components alter glue curing enzymes was tested with curing barnacle glue and with commercial enzymes. In our model, barnacle glue curing involves trypsin-like serine protease(s), which activate enzymes and structural proteins, and a transglutaminase which cross-links glue proteins. Transglutaminase activity was significantly altered upon exposure of curing glue from individual barnacles to silicone eluates. Activity of purified trypsin and, to a greater extent, transglutaminase was significantly altered by relevant concentrations of silicone polymer constituents. Surface-associated silicone compounds can disrupt glue curing and alter enzyme properties. Altered curing of natural glues has potential in fouling management.

  11. Stable supergravity dual of nonsupersymmetric glue

    International Nuclear Information System (INIS)

    Babington, James; Crooks, David E.; Evans, Nick

    2003-01-01

    We study nonsupersymmetric fermion mass and condensate deformations of the AdS conformal field theory correspondence. The five dimensional supergravity flows are lifted to a complete and remarkably simple ten dimensional background. A brane probe analysis shows that when all the fermions have an equal mass a positive mass is generated for all six scalar fields leaving nonsupersymmetric Yang-Mills theory in the deep infrared. We numerically determine the potential, produced by the background, in the Schroedinger equation relevant to the study of O ++ glueballs. The potential is a bounded well, providing evidence of stability and for a discrete, confined spectrum. The geometry can also describe the supergravity background around an (unstable) fuzzy 5-brane

  12. A New Generation of Leaching Tests – The Leaching Environmental Assessment Framework

    Science.gov (United States)

    Provides an overview of newly released leaching tests that provide a more accurate source term when estimating environmental release of metals and other constituents of potential concern (COPCs). The Leaching Environmental Assessment Framework (LEAF) methods have been (1) develo...

  13. Stroke from Delayed Embolization of Polymerized Glue Following Percutaneous Direct Injection of a Carotid Body Tumor

    Energy Technology Data Exchange (ETDEWEB)

    Krishnamoorthy, Thamburaj; Gupta, Arun Kumar; Rajan, Jayadevan E; Thomas, Bejoy [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, (India)

    2007-06-15

    Direct percutaneous embolization of hypervascular tumors results in more effective preoperative devascularization. Migration of glue is a well known complication of direct glue injection and it may lead to stroke or cranial nerve deficits. We report here on a case of carotid body tumor in a 52-year-old man; the tumor was mainly embolized by percutaneous injection of 50% glue and this was supported with balloon protection of the internal carotid artery. Thirteen hours later, he developed hemiparesis from delayed migration of glue. The possible mechanisms of this migration are discussed and preventive measures are suggested. Preoperative embolization of hypervascular tumors of the head and neck, including carotid body tumor, is often performed to decrease the amount of blood loss during surgery. Devascularization is mainly performed with particulate agents and by employing the transarterial route. More effective embolization may be achieved by performing percutaneous direct embolization of hypervascular tumors with liquid embolic agents. Even though there are few reports available on direct embolization, complications from glue migration have been reported, and this mainly happens during the procedure when the glue is in a liquid state. We report here on a case of delayed migration of polymerized glue (n-butyl-2-cyanoacrylate [NBCA]), many hours after the procedure, into the intracranial circulation and the final result was stroke. A 52-year-old male with right carotid body tumor underwent direct percutaneous glue (n-butylcyanoacrylate [NBCA]) embolization. Several hours later, he developed left hemiparesis from embolization of the polymerized glue cast. Migration of glue during percutaneous tumor embolization is presumed to occur only in the liquid state, which may lead to stroke or cranial nerve deficits. To the best of our knowledge, this is the first report of delayed glue embolization from a treated hypervascular tumor of the head and neck.

  14. The GlueX central drift chamber: Design and performance

    International Nuclear Information System (INIS)

    Van Haarlem, Y.; Meyer, C.A.; Barbosa, F.; Dey, B.; Lawrence, D.; Razmyslovich, V.; Smith, E.; Visser, G.; Whitlatch, T.; Wilkin, G.; Zihlmann, B.

    2010-01-01

    Tests and studies concerning the design and performance of the GlueX Central Drift Chamber (CDC) are presented. A full-scale prototype was built to test and steer the mechanical and electronic design. Small scale prototypes were constructed to test for sagging and to do timing and resolution studies of the detector. These studies were used to choose the gas mixture and to program a Monte Carlo simulation that can predict the detector response in an external magnetic field. Particle identification and charge division possibilities were also investigated.

  15. First Results from The GlueX Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Curtis [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2016-05-01

    The GlueX experiment at Jefferson Lab ran with its first commissioning beam in late 2014 and the spring of 2015. Data were collected on both plastic and liquid hydrogen targets, and much of the detector has been commissioned. All of the detector systems are now performing at or near design specifications and events are being fully reconstructed, including exclusive production of pi^0, eta and omega mesons. Linearly-polarized photons were successfully produced through coherent bremsstrahlung and polarization transfer to the ρ has been observed.

  16. COMDES-II: A Component-Based Framework for Generative Development of Distributed Real-Time Control Systems

    DEFF Research Database (Denmark)

    Ke, Xu; Sierszecki, Krzysztof; Angelov, Christo K.

    2007-01-01

    The paper presents a generative development methodology and component models of COMDES-II, a component-based software framework for distributed embedded control systems with real-time constraints. The adopted methodology allows for rapid modeling and validation of control software at a higher lev...... methodology for COMDES-II from a general perspective, describes the component models in details and demonstrates their application through a DC-Motor control system case study.......The paper presents a generative development methodology and component models of COMDES-II, a component-based software framework for distributed embedded control systems with real-time constraints. The adopted methodology allows for rapid modeling and validation of control software at a higher level...

  17. Three-dimensional glue detection and evaluation based on linear structured light

    Science.gov (United States)

    Xiao, Zhitao; Yang, Ruipeng; Geng, Lei; Liu, Yanbei

    2018-01-01

    During the online glue detection of body in white (BIW), the purpose of traditional glue detection based on machine vision is the localization and segmentation of glue, which is dissatisfactory for estimating the uniformity of glue with complex shape. A three-dimensional glue detection method based on the linear structured light and the movement parameters of robot is proposed. Firstly, the linear structured light and epipolar constraint algorithm are used for sign matching of binocular vision. Then, hand-eye relationship between robot and binocular camera is utilized to unified coordinate system. Finally, a structured light stripe extraction method is proposed to extract the sub-pixel coordinates of the light strip center. Experiments results demonstrate that the propose method can estimate the shape of glue accurately. For three kinds of glue with complex shape and uneven illumination, our method can detect the positions of blemishes. The absolute error of measurement is less than 1.04mm and the relative error is less than 10% respectively, which is suitable for online glue detection in BIW.

  18. Linkage and mapping analyses of the no glue egg gene Ng in the ...

    African Journals Online (AJOL)

    In the silkworm, Bombyx mori, no glue egg is mainly controlled by Ng (No glue) gene, which is located on the 12th chromosome. Owning to a lack of crossing over in females, reciprocal backcrossed F1 (BC1) progenies were used for linkage analysis and mapping of the Ng gene based on the simple sequence repeats ...

  19. Effect of MHEC on evaporation and hydration characteristics of glue mortar

    NARCIS (Netherlands)

    Faiyas, A.P.A.; Erich, S.J.F.; Huinink, H.P.; Adan, O.C.G; Nijland, T.G.

    2016-01-01

    The influence of methylhydroxyethylcellulose (MHEC) on both moisture distribution and hydration characteristics of glue mortar using nuclear magnetic resonance imaging (NMR) is investigated. MHEC is added to glue mortar in order to control the drying rate by increasing the open time. Besides drying,

  20. ERP II: a conceptual framework for next-generation enterprise systems?

    DEFF Research Database (Denmark)

    Møller, Charles

    2005-01-01

    proposes a conceptual framework for extended enterprise resource planning (ERP II). The aim of this model is to compile present ES concepts into a comprehensive outline of ERP II, thus composing a generic map and taxonomy for corporate-wide enterprise systems. Research limitations/implications - The paper...

  1. Developing a User-Driven Framework for Generating Field Data Collection Applications

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Timothy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-09-09

    This paper describes the implementation of a web-based framework, which allows end users to build custom data collection applications. The emphasis of this project is to ease the transition from handwritten forms to electronic mobile applications for data collection.

  2. Reframing Teach for America: A Conceptual Framework for the Next Generation of Scholarship

    Science.gov (United States)

    Scott, Janelle; Trujillo, Tina; Rivera, Marialena D.

    2016-01-01

    In this article, we advance a conceptual framework for the study of Teach For America (TFA) as a political and social movement with implicit and explicit ideological and political underpinnings. We argue that the second branch of TFA's mission statement, which maintains that TFA's greatest point of influence in public education is not in…

  3. Towards a Framework for Generating Tests to Satisfy Complex Code Coverage in Java Pathfinder

    Science.gov (United States)

    Staats, Matt

    2009-01-01

    We present work on a prototype tool based on the JavaPathfinder (JPF) model checker for automatically generating tests satisfying the MC/DC code coverage criterion. Using the Eclipse IDE, developers and testers can quickly instrument Java source code with JPF annotations covering all MC/DC coverage obligations, and JPF can then be used to automatically generate tests that satisfy these obligations. The prototype extension to JPF enables various tasks useful in automatic test generation to be performed, such as test suite reduction and execution of generated tests.

  4. Photoproduction of the Cascade Baryons at GlueX

    Science.gov (United States)

    Ernst, Ashley; GlueX Collaboration

    2017-09-01

    Multi-strange baryons play an important role in understanding the strong interaction and despite their importance, little is known about such hyperons. Almost all knowledge of the Cascades today stems from Kaon-nucleon interactions in bubble chamber experiments performed in the 1960s and 1970s, of which only the octet and decuplet ground states, Ξ (1320) and Ξ (1530) respectively, are well established. This research uses the GlueX experiment at Jefferson Laboratory to map out the spectrum of doubly-strange Cascade resonances, as well as to measure the spin-parity for each of the detected resonances. The first physics run for GlueX has recently been completed and a clear signature of the Ξ (1320) is observed. The systematics of the Cascade spectrum will be presented motivated by prior discoveries in the N* program. This work was supported by the U.S. Department of Energy Grant DE-FG02-92ER40735 and National Science Foundation Grant 1449440.

  5. Sediment Curve Uncertainty Estimation Using GLUE and Bootstrap Methods

    Directory of Open Access Journals (Sweden)

    aboalhasan fathabadi

    2017-02-01

    Full Text Available Introduction: In order to implement watershed practices to decrease soil erosion effects it needs to estimate output sediment of watershed. Sediment rating curve is used as the most conventional tool to estimate sediment. Regarding to sampling errors and short data, there are some uncertainties in estimating sediment using sediment curve. In this research, bootstrap and the Generalized Likelihood Uncertainty Estimation (GLUE resampling techniques were used to calculate suspended sediment loads by using sediment rating curves. Materials and Methods: The total drainage area of the Sefidrood watershed is about 560000 km2. In this study uncertainty in suspended sediment rating curves was estimated in four stations including Motorkhane, Miyane Tonel Shomare 7, Stor and Glinak constructed on Ayghdamosh, Ghrangho, GHezelOzan and Shahrod rivers, respectively. Data were randomly divided into a training data set (80 percent and a test set (20 percent by Latin hypercube random sampling.Different suspended sediment rating curves equations were fitted to log-transformed values of sediment concentration and discharge and the best fit models were selected based on the lowest root mean square error (RMSE and the highest correlation of coefficient (R2. In the GLUE methodology, different parameter sets were sampled randomly from priori probability distribution. For each station using sampled parameter sets and selected suspended sediment rating curves equation suspended sediment concentration values were estimated several times (100000 to 400000 times. With respect to likelihood function and certain subjective threshold, parameter sets were divided into behavioral and non-behavioral parameter sets. Finally using behavioral parameter sets the 95% confidence intervals for suspended sediment concentration due to parameter uncertainty were estimated. In bootstrap methodology observed suspended sediment and discharge vectors were resampled with replacement B (set to

  6. MitoGen: A Framework for Generating 3D Synthetic Time-Lapse Sequences of Cell Populations in Fluorescence Microscopy.

    Science.gov (United States)

    Svoboda, David; Ulman, Vladimir

    2017-01-01

    The proper analysis of biological microscopy images is an important and complex task. Therefore, it requires verification of all steps involved in the process, including image segmentation and tracking algorithms. It is generally better to verify algorithms with computer-generated ground truth datasets, which, compared to manually annotated data, nowadays have reached high quality and can be produced in large quantities even for 3D time-lapse image sequences. Here, we propose a novel framework, called MitoGen, which is capable of generating ground truth datasets with fully 3D time-lapse sequences of synthetic fluorescence-stained cell populations. MitoGen shows biologically justified cell motility, shape and texture changes as well as cell divisions. Standard fluorescence microscopy phenomena such as photobleaching, blur with real point spread function (PSF), and several types of noise, are simulated to obtain realistic images. The MitoGen framework is scalable in both space and time. MitoGen generates visually plausible data that shows good agreement with real data in terms of image descriptors and mean square displacement (MSD) trajectory analysis. Additionally, it is also shown in this paper that four publicly available segmentation and tracking algorithms exhibit similar performance on both real and MitoGen-generated data. The implementation of MitoGen is freely available.

  7. A conceptual framework for evaluating variable speed generator options for wind energy applications

    Science.gov (United States)

    Reddoch, T. W.; Lipo, T. A.; Hinrichsen, E. N.; Hudson, T. L.; Thomas, R. J.

    1995-01-01

    Interest in variable speed generating technology has accelerated as greater emphasis on overall efficiency and superior dynamic and control properties in wind-electric generating systems are sought. This paper reviews variable speed technology options providing advantages and disadvantages of each. Furthermore, the dynamic properties of variable speed systems are contrasted with synchronous operation. Finally, control properties of variable speed systems are examined.

  8. A Comparative Evaluation of Procedural Level Generators in the Mario AI Framework

    DEFF Research Database (Denmark)

    Horn, Britton; Dahlskog, Steve; Shaker, Noor

    dierent from another in terms of its output. To remedy this, we have conducted a large-scale comparative evaluation of level generators for the Mario AI Benchmark, a research-friendly clone of the classic platform game Super Mario Bros. In all, we compare the output of seven dierent level generators from...

  9. Handling of the Generation of Primary Events in Gauss, the LHCb Simulation Framework

    CERN Multimedia

    Corti, G; Brambach, T; Brook, N H; Gauvin, N; Harrison, K; Harrison, P; He, J; Ilten, P J; Jones, C R; Lieng, M H; Manca, G; Miglioranzi, S; Robbe, P; Vagnoni, V; Whitehead, M; Wishahi, J

    2010-01-01

    The LHCb simulation application, Gauss, consists of two independent phases, the generation of the primary event and the tracking of particles produced in the experimental setup. For the LHCb experimental program it is particularly important to model B meson decays: the EvtGen code developed in CLEO and BaBar has been chosen and customized for non coherent B production as occuring in pp collisions at the LHC. The initial proton-proton collision is provided by a different generator engine, currently Pythia 6 for massive production of signal and generic pp collisions events. Beam gas events, background events originating from proton halo, cosmics and calibration events for different detectors can be generated in addition to pp collisions. Different generator packages are available in the physics community or specifically developed in LHCb, and are used for the different purposes. Running conditions affecting the events generated such as the size of the luminous region, the number of collisions occuring in a bunc...

  10. Fibrin glue as agent for sealing corneal and conjunctival wound leaks.

    Science.gov (United States)

    Scalcione, C; Ortiz-Vaquerizas, D; Said, D G; Dua, H S

    2018-02-01

    PurposeTo describe a novel use of fibrin glue in managing leaking blebs and leaking wounds following trauma or surgery.MethodsInterventional case series.ResultsWe report eight patients, including three where intra-operative or immediate post-penetrating keratoplasty recalcitrant leaks from the graft-host junction and/or openings created by the needle pass, were noted. All three had thin recipient beds in the sector of leak. This was managed by intra-cameral injection of fibrin glue in the affected quadrant. This stopped the leak and allowed the defect to heal. One patient of Descemets-stripping-endothelial-keratoplasty had leak from the surgical wound, which was also sealed with fibrin glue. Two patients with leaking glaucoma-surgery-related blebs were treated with intra-bleb injection of fibrin glue to stop the leak. One patient with a penetrating corneal injury with a metal wire had a brisk leak upon removal of the wire. This was sealed with fibrin glue. Another patient of chemical burn with spontaneous leaks was managed by glue injection in the perforations. Transient rise of intraocular pressure in one patient with a leaking bleb was the only adverse event recorded.ConclusionThis novel adaptation of the application of fibrin glue can help to deal with persistent intra-operative, post-operative and traumatic aqueous and air leaks.

  11. An Active RBSE Framework to Generate Optimal Stimulus Sequences in a BCI for Spelling

    Science.gov (United States)

    Moghadamfalahi, Mohammad; Akcakaya, Murat; Nezamfar, Hooman; Sourati, Jamshid; Erdogmus, Deniz

    2017-10-01

    A class of brain computer interfaces (BCIs) employs noninvasive recordings of electroencephalography (EEG) signals to enable users with severe speech and motor impairments to interact with their environment and social network. For example, EEG based BCIs for typing popularly utilize event related potentials (ERPs) for inference. Presentation paradigm design in current ERP-based letter by letter typing BCIs typically query the user with an arbitrary subset characters. However, the typing accuracy and also typing speed can potentially be enhanced with more informed subset selection and flash assignment. In this manuscript, we introduce the active recursive Bayesian state estimation (active-RBSE) framework for inference and sequence optimization. Prior to presentation in each iteration, rather than showing a subset of randomly selected characters, the developed framework optimally selects a subset based on a query function. Selected queries are made adaptively specialized for users during each intent detection. Through a simulation-based study, we assess the effect of active-RBSE on the performance of a language-model assisted typing BCI in terms of typing speed and accuracy. To provide a baseline for comparison, we also utilize standard presentation paradigms namely, row and column matrix presentation paradigm and also random rapid serial visual presentation paradigms. The results show that utilization of active-RBSE can enhance the online performance of the system, both in terms of typing accuracy and speed.

  12. Developing a framework to generate evidence of health outcomes from social media use in chronic disease management.

    Science.gov (United States)

    Merolli, Mark; Gray, Kathleen; Martin-Sanchez, Fernando

    2013-01-01

    While there is an abundance of evidence-based practice (EBP) recommendations guiding management of various chronic diseases, evidence suggesting best practice for using social media to improve health outcomes is inadequate. The variety of social media platforms, multiple potential uses, inconsistent definitions, and paucity of rigorous studies, make it difficult to measure health outcomes reliably in chronic disease management. Most published investigations report on an earlier generation of online tools, which are not as user-centered, participatory, engaging, or collaborative, and thus may work differently for health self-management. The challenge to establish a sound evidence base for social media use in chronic disease starts with the need to define criteria and methods to generate and evaluate evidence. The authors' key objective is to develop a framework for research and practice that addresses this challenge. This paper forms part of a larger research project that presents a conceptual framework of how evidence of health outcomes can be generated from social media use, allowing social media to be utilized in chronic disease management more effectively. Using mixed methods incorporating a qualitative literature review, a survey and a pilot intervention, the research closely examines the therapeutic affordances of social media, people with chronic pain (PWCP) as a subset of chronic disease management, valid outcome measurement of patient-reported (health) outcomes (PRO), the individual needs of people living with chronic disease, and finally translation of the combined results to improve evidence-based decision making about social media use in this context. Extensive review highlights various affordances of social media that may prove valuable to understanding social media's effect on individual health outcomes. However, without standardized PRO instruments, we are unable to definitively investigate these effects. The proposed framework that we offer outlines

  13. Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses

    DEFF Research Database (Denmark)

    Nordentoft, Tyge; Pommergaard, Hans-Christian; Rosenberg, Jacob

    2015-01-01

    BACKGROUND/AIM: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin...... glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence....... It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se....

  14. A framework for QoS & mobility in the Internet next generation

    NARCIS (Netherlands)

    Rexhepi, Vlora; Karagiannis, Georgios; Heijenk, Geert; Pras, Aiko

    2000-01-01

    It is expected that the Internet next generation architecture will support applications with different quality of service requirements, independently of whether their location is fixed or mobile. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

  15. A framework for QoS & mobility in the Internet next generation

    NARCIS (Netherlands)

    Karagiannis, Georgios; Rexhepi, Vlora; Heijenk, Geert

    It is expected that the next generation Internet architecture will support applications with different quality of service requirements, independently of whether their location is fixed or movable. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

  16. On a framework for generating PoD curves assisted by numerical simulations

    Energy Technology Data Exchange (ETDEWEB)

    Subair, S. Mohamed, E-mail: prajagopal@iitm.ac.in; Agrawal, Shweta, E-mail: prajagopal@iitm.ac.in; Balasubramaniam, Krishnan, E-mail: prajagopal@iitm.ac.in; Rajagopal, Prabhu, E-mail: prajagopal@iitm.ac.in [Indian Institute of Technology Madras, Department of Mechanical Engineering, Chennai, T.N. (India); Kumar, Anish; Rao, Purnachandra B.; Tamanna, Jayakumar [Indira Gandhi Centre for Atomic Research, Metallurgy and Materials Group, Kalpakkam, T.N. (India)

    2015-03-31

    The Probability of Detection (PoD) curve method has emerged as an important tool for the assessment of the performance of NDE techniques, a topic of particular interest to the nuclear industry where inspection qualification is very important. The conventional experimental means of generating PoD curves though, can be expensive, requiring large data sets (covering defects and test conditions), and equipment and operator time. Several methods of achieving faster estimates for PoD curves using physics-based modelling have been developed to address this problem. Numerical modelling techniques are also attractive, especially given the ever-increasing computational power available to scientists today. Here we develop procedures for obtaining PoD curves, assisted by numerical simulation and based on Bayesian statistics. Numerical simulations are performed using Finite Element analysis for factors that are assumed to be independent, random and normally distributed. PoD curves so generated are compared with experiments on austenitic stainless steel (SS) plates with artificially created notches. We examine issues affecting the PoD curve generation process including codes, standards, distribution of defect parameters and the choice of the noise threshold. We also study the assumption of normal distribution for signal response parameters and consider strategies for dealing with data that may be more complex or sparse to justify this. These topics are addressed and illustrated through the example case of generation of PoD curves for pulse-echo ultrasonic inspection of vertical surface-breaking cracks in SS plates.

  17. Conceptual framework for the study of food waste generation and prevention in the hospitality sector

    NARCIS (Netherlands)

    Papargyropoulou, Effie; Wright, Nigel; Lozano, Rodrigo|info:eu-repo/dai/nl/36412380X; Steinberger, Julia; Padfield, Rory; Ujang, Zaini

    2016-01-01

    Food waste has significant detrimental economic, environmental and social impacts. The magnitude and complexity of the global food waste problem has brought it to the forefront of the environmental agenda; however, there has been little research on the patterns and drivers of food waste generation,

  18. Development of a Next Generation Concurrent Framework for the ATLAS Experiment

    CERN Document Server

    Leggett, Charles; The ATLAS collaboration; Calafiura, Paolo; Wynne, Benjamin; Malon, David; Lampl, Walter

    2015-01-01

    The ATLAS experiment has successfully used its Gaudi/Athena software framework for data taking and analysis during the first LHC run, with billions of events successfully processed. However, the design of Gaudi/Athena dates from early 2000 and the software and the physics code has been written using a single threaded, serial design. This programming model has increasing difficulty in exploiting the potential of current CPUs, which offer their best performance only through taking full advantage of multiple cores and wide vector registers. Future CPU evolution will intensify this trend, with core counts increasing and memory per core falling. With current memory consumption for 64 bit ATLAS reconstruction in a high luminosity environment approaching 4GB, it will become impossible to fully occupy all cores in a machine without exhausting available memory. However, since maximizing performance per watt will be a key metric, a mechanism must be found to use all cores as efficiently as possible. In this paper we re...

  19. Development of a Next Generation Concurrent Framework for the ATLAS Experiment

    CERN Document Server

    Leggett, Charles; The ATLAS collaboration; Lampl, Walter; Malon, David; Stewart, Graeme; Wynne, Benjamin

    2015-01-01

    The ATLAS experiment has successfully used its Gaudi/Athena software framework for data taking and analysis during the first LHC run, with billions of events successfully processed. However, the design of Gaudi/Athena dates from early 2000 and the software and the physics code has been written using a single threaded, serial design. This programming model has increasing difficulty in exploiting the potential of current CPUs, which offer their best performance only through taking full advantage of multiple cores and wide vector registers. Future CPU evolution will intensify this trend, with core counts increasing and memory per core falling. With current memory consumption for 64 bit ATLAS reconstruction in a high luminosity environment approaching 4GB, it will become impossible to fully occupy all cores in a machine without exhausting available memory. However, since maximising performance per watt will be a key metric, a mechanism must be found to use all cores as efficiently as possible. In this paper we re...

  20. Krazy Glue® in the ear: A case report of child abuse.

    Science.gov (United States)

    Sorichetti, Brendan D; Fandiño, Marcela; Kozak, Frederick K

    2018-06-01

    Krazy Glue ® or cyanoacrylate glue is an acrylic resin that polymerizes in less than a minute when in contact with moisture or water. We present a case of a one month old referred to our tertiary pediatric otolaryngology clinic from an outside emergency department with a history of application of cyanoacrylate glue in the external ear canals. This report presents the management of this case along with the medical and legal outcomes surrounding this case of child abuse. Copyright © 2018. Published by Elsevier B.V.

  1. DPLFW: a Framework for the Product-Line-Based Generation of Variable Content Documents

    OpenAIRE

    Gómez , Abel; Martí , Pau; Penadés , M. Carmen; Canós , José H.

    2014-01-01

    International audience; Document Product Lines (DPL) is a document engineering methodology that applies product-line engineering principles to the gen-eration of documents in high variability contexts and with high reuse of components. Instead of standalone documents, DPL promotes the defi-nition of families of documents where the members share some common content while differ in other parts. The key for the definition is the avail-ability of a collection of content assets which can be parame...

  2. Development of an Integrated Intelligent Multi -Objective Framework for UAV Trajectory Generation

    Science.gov (United States)

    Wilburn, Jennifer Nicole

    This thesis explores a variety of path planning and trajectory generation schemes intended for small, fixed-wing Unmanned Aerial Vehicles. Throughout this analysis, discrete and pose-based methods are investigated. Pose-based methods are the focus of this research due to their increased flexibility and typically lower computational overhead. Path planning in 3 dimensions is also performed. The 3D Dubins methodology presented is an extension of a previously suggested approach and addresses both the mathematical formulation of the methodology, as well as an assessment of numerical issues encountered and the solutions implemented for these. The main contribution of this thesis is a 3-dimensional clothoid trajectory generation algorithm, which produces flyable paths of continuous curvature to ensure a more followable commanded path. This methodology is an extension of the 3D Dubins method and the 2D clothoid method, which have been implemented herein. To ensure flyability of trajectories produced by 3D pose-based trajectory generation methodologies, a set of criteria are specified to limit the possible solutions to only those flyable by the aircraft. Additionally, several assumptions are made concerning the motion of the aircraft in order to simplify the path generation problem. The 2D and 3D clothoid and Dubins trajectory planners are demonstrated through a trajectory tracking performance comparison between first the 2D Dubins and 2D clothoid methods using a position proportional-integral-derivative controller, then the 3D Dubins and 3D clothoid methods using both a position proportional-integral-derivative controller and an outer-loop non-linear dynamic inversion controller, within the WVU UAV Simulation Environment. These comparisons are demonstrated for both nominal and off-nominal conditions, and show that for both 2D and 3D implementations, the clothoid path planners yields paths with better trajectory tracking performance as compared to the Dubins path planners

  3. Risk perception and strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy

    International Nuclear Information System (INIS)

    Brewer, Jeffrey D.

    2005-01-01

    The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate the wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system

  4. A Framework for Understanding and Generating Integrated Solutions for Residential Peak Energy Demand

    Science.gov (United States)

    Buys, Laurie; Vine, Desley; Ledwich, Gerard; Bell, John; Mengersen, Kerrie; Morris, Peter; Lewis, Jim

    2015-01-01

    Supplying peak energy demand in a cost effective, reliable manner is a critical focus for utilities internationally. Successfully addressing peak energy concerns requires understanding of all the factors that affect electricity demand especially at peak times. This paper is based on past attempts of proposing models designed to aid our understanding of the influences on residential peak energy demand in a systematic and comprehensive way. Our model has been developed through a group model building process as a systems framework of the problem situation to model the complexity within and between systems and indicate how changes in one element might flow on to others. It is comprised of themes (social, technical and change management options) networked together in a way that captures their influence and association with each other and also their influence, association and impact on appliance usage and residential peak energy demand. The real value of the model is in creating awareness, understanding and insight into the complexity of residential peak energy demand and in working with this complexity to identify and integrate the social, technical and change management option themes and their impact on appliance usage and residential energy demand at peak times. PMID:25807384

  5. Overpressure generation by load transfer following shale framework weakening due to smectite diagenesis

    Science.gov (United States)

    Lahann, R.W.; Swarbrick, R.E.

    2011-01-01

    Basin model studies which have addressed the importance of smectite conversion to illite as a source of overpressure in the Gulf of Mexico have principally relied on a single-shale compaction model and treated the smectite reaction as only a fluid-source term. Recent fluid pressure interpretation and shale petrology studies indicate that conversion of bound water to mobile water, dissolution of load-bearing grains, and increased preferred orientation change the compaction properties of the shale. This results in substantial changes in effective stress and fluid pressure. The resulting fluid pressure can be 1500-3000psi higher than pressures interpreted from models based on shallow compaction trends. Shale diagenesis changes the mineralogy, volume, and orientation of the load-bearing grains in the shale as well as the volume of bound water. This process creates a weaker (more compactable) grain framework. When these changes occur without fluid export from the shale, some of the stress is transferred from the grains onto the fluid. Observed relationships between shale density and calculated effective stress in Gulf of Mexico shelf wells confirm these changes in shale properties with depth. Further, the density-effective stress changes cannot be explained by fluid-expansion or fluid-source processes or by prediagenesis compaction, but are consistent with a dynamic diagenetic modification of the shale mineralogy, texture, and compaction properties during burial. These findings support the incorporation of diagenetic modification of compaction properties as part of the fluid pressure interpretation process. ?? 2011 Blackwell Publishing Ltd.

  6. Generating renewable energy from oil palm biomass in Malaysia: The Feed-in Tariff policy framework

    International Nuclear Information System (INIS)

    Umar, Mohd Shaharin; Jennings, Philip; Urmee, Tania

    2014-01-01

    The renewable energy (RE) industry in Malaysia began in 2001 in the context of the growing concern about future depletion of conventional fuels and the global environmental concerns about greenhouse gas emissions. The Small Renewable Energy Programme (SREP) is a tool that was first designed to drive the development of the industry based on the abundance of oil palm biomass reserves and other identified renewable energy resources. Due to the slow uptake of this scheme, a new system, the Feed-in Tariff (FiT) was introduced in 2011 to stimulate the industry. By considering the deficiencies of the previous scheme, this paper examines the sustainability of the FiT policy framework in steering the future expansion of small-scale biomass renewable energy businesses in Malaysia. Resulting from the evaluation of the current policy settings and a market based appraisal, this work outlines strategies for enhancing the scheme and suggests future studies aimed at improving the flaws in the present system. - Highlights: • Extend the FiT bandwidth capacity restrictions to all of the eligible renewable technologies under the FiT systems. • Differentiate the tariff level by considering the location and local conditions of the plant site. • Modify the revenue streams from the renewable fund. • Revise the quota system

  7. In situ generation of Ni nanoparticles from metal-organic framework precursors and their use for biomass hydrodeoxygenation.

    Science.gov (United States)

    Čelič, Tadeja Birsa; Grilc, Miha; Likozar, Blaž; Tušar, Nataša Novak

    2015-05-22

    So far, in situ-generated Ni nanoparticles have been reported to be efficient catalysts for tar cracking during wood liquefaction by pyrolysis. Herein, their performance in further bio-oil conversion steps is evaluated. Nanoparticles were generated for the first time from a Ni-containing metal-organic framework, MIL-77, during the hydrotreatment of glycerol-solvolyzed lignocellulosic (LC) biomass. Reactions were conducted at 300 °C and the H2 pressure was 8 MPa in a slurry reactor. The catalytic activity and selectivity of the deoxygenation and hydrocracking reactions for real biomass-derived feedstock using in situ-generated nanoparticles was compared with Ni nanoparticles dispersed on a silica-alumina support (commercial Ni/SiO2 -Al2 O3 catalyst). The mass activity of the in situ-generated nanoparticles for hydrogenolysis was more than ten times higher in comparison to their commercial analogues, and their potential for the use in LC biorefinery is discussed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Identifying problems and generating recommendations for enhancing complex systems: applying the abstraction hierarchy framework as an analytical tool.

    Science.gov (United States)

    Xu, Wei

    2007-12-01

    This study adopts J. Rasmussen's (1985) abstraction hierarchy (AH) framework as an analytical tool to identify problems and pinpoint opportunities to enhance complex systems. The process of identifying problems and generating recommendations for complex systems using conventional methods is usually conducted based on incompletely defined work requirements. As the complexity of systems rises, the sheer mass of data generated from these methods becomes unwieldy to manage in a coherent, systematic form for analysis. There is little known work on adopting a broader perspective to fill these gaps. AH was used to analyze an aircraft-automation system in order to further identify breakdowns in pilot-automation interactions. Four steps follow: developing an AH model for the system, mapping the data generated by various methods onto the AH, identifying problems based on the mapped data, and presenting recommendations. The breakdowns lay primarily with automation operations that were more goal directed. Identified root causes include incomplete knowledge content and ineffective knowledge structure in pilots' mental models, lack of effective higher-order functional domain information displayed in the interface, and lack of sufficient automation procedures for pilots to effectively cope with unfamiliar situations. The AH is a valuable analytical tool to systematically identify problems and suggest opportunities for enhancing complex systems. It helps further examine the automation awareness problems and identify improvement areas from a work domain perspective. Applications include the identification of problems and generation of recommendations for complex systems as well as specific recommendations regarding pilot training, flight deck interfaces, and automation procedures.

  9. A prototype data assimilation framework for generating spatiotemporally continuous SWOT data products

    Science.gov (United States)

    Andreadis, K.; Margulis, S. A.; Li, D.; Lettenmaier, D. P.

    2017-12-01

    The Surface Water and Ocean Topography (SWOT) satellite will provide critical surface water observations for the hydrologic community. However, production of key SWOT variables, such as river discharge and surface inundation, as well as lake, reservoir, and wetland storage change will be complicated by the discontinuity of the observations in space and time. A methodology that generates products with spatially and temporally continuous fields based on SWOT observables would be highly desirable. Data assimilation provides a mechanism for merging observations from SWOT with model predictions in order to produce estimates of quantities such as river discharge, storage change, and water heights for locations and times when there is no satellite overpass or other constraints (such as layover) render the measurement unusable. We describe here a prototype assimilation system with application to the Upper Mississippi basin, implemented using synthetic SWOT observations. We use a hydrologic model (VIC) coupled with a hydrodynamic model (LISFLOOD-FP) which generates "true" fields of surface water variables. The true fields are then used to generate synthetic SWOT observations using the SWOT Instrument Simulator. We also perform a "first-guess" (or open-loop) simulation with the coupled model using a configuration that contains errors representative of the imperfect knowledge of parameters and input data, including channel topography, bankfull widths and depths, and inflows, to create an ensemble of 20 model trajectories. Subsequently we assimilate the synthetic SWOT observations into the open-loop model results to estimate water surface elevation, discharge, and storage change. Our preliminary results using three data assimilation strategies show that all improve the water surface elevation estimate accuracy by 25% - 35% for a river reach of the upper Mississippi River. Ongoing work is examining whether the improved water surface elevation estimates propagate to improvements

  10. Development of a framework for the neutronics analysis system for next generation (Contract research)

    International Nuclear Information System (INIS)

    Tatsumi, Masahiro; Yokoyama, Kenji

    2007-11-01

    In JAEA, authors has been promoting the development of an object-oriented next-generation neutronics analysis system in order to reflect the latest methods and models of reactor analysis to basic designs and operations of fast reactors in the efficient and effective way. A purpose of the developing system is to effectively realize requirements that has been difficult to manage in the conventional systems, such as change of analysis targets and change of analysis modeling levels. For the realization of the requirements, the authors adopted the two-layer model which consists of a control layer written in the Python as an object-oriented scripting language and a solver layer in the C++ as a system programming language. After having studied the principle on the two-layer model in the next-generation neutronics analysis system, the authors designed and implemented a library that enabled transparent transfer of data objects between the two layers. In each layer, appropriate numerical library was used for better performance. In the present library, a model proxy was implemented to exchange internal data that is represented in different ways in each layer. With this mechanism of the model proxy, it confirmed that data exchange between the layers can be performed easily and effectively. (author)

  11. Informal uncertainty analysis (GLUE of continuous flow simulation in a hybrid sewer system with infiltration inflow – consistency of containment ratios in calibration and validation?

    Directory of Open Access Journals (Sweden)

    A. Breinholt

    2013-10-01

    Full Text Available Monitoring of flows in sewer systems is increasingly applied to calibrate urban drainage models used for long-term simulation. However, most often models are calibrated without considering the uncertainties. The generalized likelihood uncertainty estimation (GLUE methodology is here applied to assess parameter and flow simulation uncertainty using a simplified lumped sewer model that accounts for three separate flow contributions: wastewater, fast runoff from paved areas, and slow infiltrating water from permeable areas. Recently GLUE methodology has been critisised for generating prediction limits without statistical coherence and consistency and for the subjectivity in the choice of a threshold value to distinguish "behavioural" from "non-behavioural" parameter sets. In this paper we examine how well the GLUE methodology performs when the behavioural parameter sets deduced from a calibration period are applied to generate prediction bounds in validation periods. By retaining an increasing number of parameter sets we aim at obtaining consistency between the GLUE generated 90% prediction limits and the actual containment ratio (CR in calibration. Due to the large uncertainties related to spatio-temporal rain variability during heavy convective rain events, flow measurement errors, possible model deficiencies as well as epistemic uncertainties, it was not possible to obtain an overall CR of more than 80%. However, the GLUE generated prediction limits still proved rather consistent, since the overall CRs obtained in calibration corresponded well with the overall CRs obtained in validation periods for all proportions of retained parameter sets evaluated. When focusing on wet and dry weather periods separately, some inconsistencies were however found between calibration and validation and we address here some of the reasons why we should not expect the coverage of the prediction limits to be identical in calibration and validation periods in real

  12. Observations on dimensional changes of sized canvas based on glue temperature

    DEFF Research Database (Denmark)

    Krarup Andersen, Cecil

    2008-01-01

    The aim of this study was to explore dimensional changes caused by water on sized canvas. Samples of new linen canvas were mounted on a rig for biaxial tensioning, holding a constant stress of 100 N/m in both weave directions. The samples were then sized with respectively warm fluent glue (45 °C......) or a cold gel (20 °C), both consisting of a 5 percent sheepskin glue extracted from parchment clippings. The warm glue was absorbed into the canvas structure, whereas the cold gel mostly stayed as a discrete layer on the canvas. Twice the amount of glue was therefore needed for the warm sizing. When...... of size layers during application is important to the dimensional reaction of a canvas painting that is exposed to water....

  13. Event based uncertainty assessment in urban drainage modelling, applying the GLUE methodology

    DEFF Research Database (Denmark)

    Thorndahl, Søren; Beven, K.J.; Jensen, Jacob Birk

    2008-01-01

    of combined sewer overflow. The GLUE methodology is used to test different conceptual setups in order to determine if one model setup gives a better goodness of fit conditional on the observations than the other. Moreover, different methodological investigations of GLUE are conducted in order to test......In the present paper an uncertainty analysis on an application of the commercial urban drainage model MOUSE is conducted. Applying the Generalized Likelihood Uncertainty Estimation (GLUE) methodology the model is conditioned on observation time series from two flow gauges as well as the occurrence...... if the uncertainty analysis is unambiguous. It is shown that the GLUE methodology is very applicable in uncertainty analysis of this application of an urban drainage model, although it was shown to be quite difficult of get good fits of the whole time series....

  14. Sealing of Gastrointestinal Anastomoses with a Fibrin Glue-Coated Collagen Patch: A Safety Study

    DEFF Research Database (Denmark)

    Nordentoft, Tyge; Rømer, John; Sørensen, Michael

    2007-01-01

    gastrointestinal anastomoses with a collagen patch coated with fibrin glue. The study is a prospective, experimental animal study comparing sealed and unsealed gastrointestinal anastomoses. Laparotomy was performed in 11 pigs under general anesthesia. In each pig two anastomoses were performed on the small......Sealing of anastomoses has previously been tested with several methods, including sealing with liquid fibrin glue. Sealing with a collagen patch coated with fibrin glue components has never been systematically examined. The aim of the present study was to determine the safety of sealing...... intestine. One of the anastomoses was sealed with a collagen patch coated with fibrin glue components (TachoSil). The other anastomosis contained no sealing. The pigs were observed for 1 to 6 weeks. The observation period was followed by in vivo examination under general anesthesia and included observation...

  15. The use of snake venom derived fibrin glue in hysterorrhaphy of ovine caesarean surgery

    OpenAIRE

    CHALHOUB, M.; PRESTES, N. C.; LOPES, M. D.; ROCHA, N. S.; THOMAZINI-SANTOS, I. A.; MENDES-GIANNINI, M.J.

    2000-01-01

    Fibrin glue has been used on its own or in conjunction with suturing materials to promote hemostasis, reduce adherence, strengthen the wound site, and improve healing. Snake venom derived fibrin glue was evaluated as an alternative to conventional uterine suturing after ovine caesarean surgery. Twenty-eight pregnant ewes of known mating date were used. The animals submitted to conventional caesarean sections showed a better wound healing process. As expected, all the operated animals had reta...

  16. Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs

    OpenAIRE

    Đenić Nebojša; Višnjić Milan; Dragović Saša; Bojanić Vladmila; Bojanić Zoran; Đurđević Dragan; Đinđić Boris; Kostov Miloš

    2015-01-01

    Background/Aim. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as a local hemostatic and as a matrix for the local dosed release of antibiotics. Antibiotics addition to fibrin glue resulted in continuous diffusion into the surrounding n...

  17. Measurement of radiation damage on an epoxy-based optical glue

    International Nuclear Information System (INIS)

    Huang, H.C.; Peng, K.C.; Sahu, S.K.; Ueno, K.; Chang, Y.H.; Wang, C.H.; Hou, W.S.

    1997-01-01

    We measured the radiation damage on an optical glue called Eccobond-24, which is a candidate for CsI and BGO crystal calorimeters of the BELLE detector of the KEK B-factory. Absorption spectrophotometry in the range 300-800 nm was used to monitor the radiation damage. The maximum equivalent dose was 1.64 Mrad. The glue shows effects of damage, but is acceptable for the radiation level in the above-mentioned experiment. (orig.)

  18. Double Coaxial Microcatheter Technique for Glue Embolization of Renal Arteriovenous Malformations

    International Nuclear Information System (INIS)

    Uchikawa, Yoko; Mori, Kensaku; Shiigai, Masanari; Konishi, Takahiro; Hoshiai, Sodai; Ishigro, Toshitaka; Hiyama, Takashi; Nakai, Yasunobu; Minami, Manabu

    2015-01-01

    PurposeTo demonstrate the technical benefit of the double coaxial microcatheter technique for embolization of renal arteriovenous malformations (AVMs) with n-butyl cyanoacrylate and iodized oil (glue).Materials and MethodsSix consecutive patients (1 man and 5 women; mean age 61 years; range 44–77 years) with renal AVMs were included. Five patients had hematuria, and one had a risk of heart failure due to a large intrarenal arteriovenous shunt. All patients underwent transarterial embolization using glue and the double coaxial microcatheter technique with outer 2.6F and inner 1.9F microcatheters. After glue injection, the inner microcatheter was retracted, while the outer microcatheter was retained. We assessed the complications and clinical outcomes of this technique.ResultsTechnical success was achieved in all patients. In 9 sessions, 34 feeding arteries were embolized with glue using the double coaxial microcatheter technique, 1 was embolized with glue using a single microcatheter, and 2 were embolized with coils. The double coaxial microcatheter technique was useful for selecting small tortuous feeding arteries, preventing glue reflux to the proximal arteries, and approaching multiple feeding arteries without complete retraction of the microcatheters. As a minor complication, glue migrated into the venous system in four patients without any sequelae. In all patients, favorable clinical outcomes, including hematuria cessation in five patients and improvement of the large intrarenal arteriovenous shunt in one patient, were obtained without deterioration of renal function.ConclusionGlue embolization with the double coaxial microcatheter technique was useful for treating renal AVMs with multiple tortuous feeding arteries

  19. Double Coaxial Microcatheter Technique for Glue Embolization of Renal Arteriovenous Malformations

    Energy Technology Data Exchange (ETDEWEB)

    Uchikawa, Yoko, E-mail: jauchikawa@gmail.com [University of Tsukuba Hospital, Department of Radiology (Japan); Mori, Kensaku, E-mail: moriken@md.tsukuba.ac.jp [University of Tsukuba, Department of Radiology, Faculty of Medicine (Japan); Shiigai, Masanari, E-mail: m-41gai@yahoo.co.jp [Tsukuba Medical Center Hospital, Department of Radiology (Japan); Konishi, Takahiro, E-mail: soratobukangaruu@gmail.com [University of Tsukuba Hospital, Department of Radiology (Japan); Hoshiai, Sodai, E-mail: hoshiai@sb4.so-net.ne.jp [Ibaraki Prefectural Central Hospital, Department of Radiology (Japan); Ishigro, Toshitaka, E-mail: suzutokei@gmail.com; Hiyama, Takashi, E-mail: med-tak@hotmail.com [University of Tsukuba Hospital, Department of Radiology (Japan); Nakai, Yasunobu, E-mail: nakaiya@tmch.or.jp [Tsukuba Medical Center Hospital, Department of Neurosurgery (Japan); Minami, Manabu, E-mail: mminami@md.tsukuba.ac.jp [University of Tsukuba, Department of Radiology, Faculty of Medicine (Japan)

    2015-10-15

    PurposeTo demonstrate the technical benefit of the double coaxial microcatheter technique for embolization of renal arteriovenous malformations (AVMs) with n-butyl cyanoacrylate and iodized oil (glue).Materials and MethodsSix consecutive patients (1 man and 5 women; mean age 61 years; range 44–77 years) with renal AVMs were included. Five patients had hematuria, and one had a risk of heart failure due to a large intrarenal arteriovenous shunt. All patients underwent transarterial embolization using glue and the double coaxial microcatheter technique with outer 2.6F and inner 1.9F microcatheters. After glue injection, the inner microcatheter was retracted, while the outer microcatheter was retained. We assessed the complications and clinical outcomes of this technique.ResultsTechnical success was achieved in all patients. In 9 sessions, 34 feeding arteries were embolized with glue using the double coaxial microcatheter technique, 1 was embolized with glue using a single microcatheter, and 2 were embolized with coils. The double coaxial microcatheter technique was useful for selecting small tortuous feeding arteries, preventing glue reflux to the proximal arteries, and approaching multiple feeding arteries without complete retraction of the microcatheters. As a minor complication, glue migrated into the venous system in four patients without any sequelae. In all patients, favorable clinical outcomes, including hematuria cessation in five patients and improvement of the large intrarenal arteriovenous shunt in one patient, were obtained without deterioration of renal function.ConclusionGlue embolization with the double coaxial microcatheter technique was useful for treating renal AVMs with multiple tortuous feeding arteries.

  20. Phenotype Instance Verification and Evaluation Tool (PIVET): A Scaled Phenotype Evidence Generation Framework Using Web-Based Medical Literature

    Science.gov (United States)

    Ke, Junyuan; Ho, Joyce C; Ghosh, Joydeep; Wallace, Byron C

    2018-01-01

    Background Researchers are developing methods to automatically extract clinically relevant and useful patient characteristics from raw healthcare datasets. These characteristics, often capturing essential properties of patients with common medical conditions, are called computational phenotypes. Being generated by automated or semiautomated, data-driven methods, such potential phenotypes need to be validated as clinically meaningful (or not) before they are acceptable for use in decision making. Objective The objective of this study was to present Phenotype Instance Verification and Evaluation Tool (PIVET), a framework that uses co-occurrence analysis on an online corpus of publically available medical journal articles to build clinical relevance evidence sets for user-supplied phenotypes. PIVET adopts a conceptual framework similar to the pioneering prototype tool PheKnow-Cloud that was developed for the phenotype validation task. PIVET completely refactors each part of the PheKnow-Cloud pipeline to deliver vast improvements in speed without sacrificing the quality of the insights PheKnow-Cloud achieved. Methods PIVET leverages indexing in NoSQL databases to efficiently generate evidence sets. Specifically, PIVET uses a succinct representation of the phenotypes that corresponds to the index on the corpus database and an optimized co-occurrence algorithm inspired by the Aho-Corasick algorithm. We compare PIVET’s phenotype representation with PheKnow-Cloud’s by using PheKnow-Cloud’s experimental setup. In PIVET’s framework, we also introduce a statistical model trained on domain expert–verified phenotypes to automatically classify phenotypes as clinically relevant or not. Additionally, we show how the classification model can be used to examine user-supplied phenotypes in an online, rather than batch, manner. Results PIVET maintains the discriminative power of PheKnow-Cloud in terms of identifying clinically relevant phenotypes for the same corpus with

  1. Phenotype Instance Verification and Evaluation Tool (PIVET): A Scaled Phenotype Evidence Generation Framework Using Web-Based Medical Literature.

    Science.gov (United States)

    Henderson, Jette; Ke, Junyuan; Ho, Joyce C; Ghosh, Joydeep; Wallace, Byron C

    2018-05-04

    Researchers are developing methods to automatically extract clinically relevant and useful patient characteristics from raw healthcare datasets. These characteristics, often capturing essential properties of patients with common medical conditions, are called computational phenotypes. Being generated by automated or semiautomated, data-driven methods, such potential phenotypes need to be validated as clinically meaningful (or not) before they are acceptable for use in decision making. The objective of this study was to present Phenotype Instance Verification and Evaluation Tool (PIVET), a framework that uses co-occurrence analysis on an online corpus of publically available medical journal articles to build clinical relevance evidence sets for user-supplied phenotypes. PIVET adopts a conceptual framework similar to the pioneering prototype tool PheKnow-Cloud that was developed for the phenotype validation task. PIVET completely refactors each part of the PheKnow-Cloud pipeline to deliver vast improvements in speed without sacrificing the quality of the insights PheKnow-Cloud achieved. PIVET leverages indexing in NoSQL databases to efficiently generate evidence sets. Specifically, PIVET uses a succinct representation of the phenotypes that corresponds to the index on the corpus database and an optimized co-occurrence algorithm inspired by the Aho-Corasick algorithm. We compare PIVET's phenotype representation with PheKnow-Cloud's by using PheKnow-Cloud's experimental setup. In PIVET's framework, we also introduce a statistical model trained on domain expert-verified phenotypes to automatically classify phenotypes as clinically relevant or not. Additionally, we show how the classification model can be used to examine user-supplied phenotypes in an online, rather than batch, manner. PIVET maintains the discriminative power of PheKnow-Cloud in terms of identifying clinically relevant phenotypes for the same corpus with which PheKnow-Cloud was originally developed, but

  2. Probabilistic Models and Generative Neural Networks: Towards an Unified Framework for Modeling Normal and Impaired Neurocognitive Functions.

    Science.gov (United States)

    Testolin, Alberto; Zorzi, Marco

    2016-01-01

    Connectionist models can be characterized within the more general framework of probabilistic graphical models, which allow to efficiently describe complex statistical distributions involving a large number of interacting variables. This integration allows building more realistic computational models of cognitive functions, which more faithfully reflect the underlying neural mechanisms at the same time providing a useful bridge to higher-level descriptions in terms of Bayesian computations. Here we discuss a powerful class of graphical models that can be implemented as stochastic, generative neural networks. These models overcome many limitations associated with classic connectionist models, for example by exploiting unsupervised learning in hierarchical architectures (deep networks) and by taking into account top-down, predictive processing supported by feedback loops. We review some recent cognitive models based on generative networks, and we point out promising research directions to investigate neuropsychological disorders within this approach. Though further efforts are required in order to fill the gap between structured Bayesian models and more realistic, biophysical models of neuronal dynamics, we argue that generative neural networks have the potential to bridge these levels of analysis, thereby improving our understanding of the neural bases of cognition and of pathologies caused by brain damage.

  3. My-Forensic-Loci-queries (MyFLq) framework for analysis of forensic STR data generated by massive parallel sequencing.

    Science.gov (United States)

    Van Neste, Christophe; Vandewoestyne, Mado; Van Criekinge, Wim; Deforce, Dieter; Van Nieuwerburgh, Filip

    2014-03-01

    Forensic scientists are currently investigating how to transition from capillary electrophoresis (CE) to massive parallel sequencing (MPS) for analysis of forensic DNA profiles. MPS offers several advantages over CE such as virtually unlimited multiplexy of loci, combining both short tandem repeat (STR) and single nucleotide polymorphism (SNP) loci, small amplicons without constraints of size separation, more discrimination power, deep mixture resolution and sample multiplexing. We present our bioinformatic framework My-Forensic-Loci-queries (MyFLq) for analysis of MPS forensic data. For allele calling, the framework uses a MySQL reference allele database with automatically determined regions of interest (ROIs) by a generic maximal flanking algorithm which makes it possible to use any STR or SNP forensic locus. Python scripts were designed to automatically make allele calls starting from raw MPS data. We also present a method to assess the usefulness and overall performance of a forensic locus with respect to MPS, as well as methods to estimate whether an unknown allele, which sequence is not present in the MySQL database, is in fact a new allele or a sequencing error. The MyFLq framework was applied to an Illumina MiSeq dataset of a forensic Illumina amplicon library, generated from multilocus STR polymerase chain reaction (PCR) on both single contributor samples and multiple person DNA mixtures. Although the multilocus PCR was not yet optimized for MPS in terms of amplicon length or locus selection, the results show excellent results for most loci. The results show a high signal-to-noise ratio, correct allele calls, and a low limit of detection for minor DNA contributors in mixed DNA samples. Technically, forensic MPS affords great promise for routine implementation in forensic genomics. The method is also applicable to adjacent disciplines such as molecular autopsy in legal medicine and in mitochondrial DNA research. Copyright © 2013 The Authors. Published by

  4. Fuzziness-based active learning framework to enhance hyperspectral image classification performance for discriminative and generative classifiers.

    Directory of Open Access Journals (Sweden)

    Muhammad Ahmad

    Full Text Available Hyperspectral image classification with a limited number of training samples without loss of accuracy is desirable, as collecting such data is often expensive and time-consuming. However, classifiers trained with limited samples usually end up with a large generalization error. To overcome the said problem, we propose a fuzziness-based active learning framework (FALF, in which we implement the idea of selecting optimal training samples to enhance generalization performance for two different kinds of classifiers, discriminative and generative (e.g. SVM and KNN. The optimal samples are selected by first estimating the boundary of each class and then calculating the fuzziness-based distance between each sample and the estimated class boundaries. Those samples that are at smaller distances from the boundaries and have higher fuzziness are chosen as target candidates for the training set. Through detailed experimentation on three publically available datasets, we showed that when trained with the proposed sample selection framework, both classifiers achieved higher classification accuracy and lower processing time with the small amount of training data as opposed to the case where the training samples were selected randomly. Our experiments demonstrate the effectiveness of our proposed method, which equates favorably with the state-of-the-art methods.

  5. A framework for investigating the interactions between climate, dust, solar power generation and water desalination processes in Desert Climate

    Science.gov (United States)

    Siam, M. S.; Alqatari, S.; Ibrahim, H. D.; AlAloula, R. A.; Alrished, M.; AlSaati, A.; Eltahir, E. A. B.

    2016-12-01

    Increasing water demand in Saudi Arabia due to rapid population growth has forced the rapid expansion of seawater desalination plants in order to meet both current and future freshwater needs. Saudi Arabia has a huge potential for solar energy, hence, solar-powered desalination plants provide an opportunity to sustainably address the freshwater demand in the kingdom without relying on fossil fuels energy. However, the desert climate of Saudi Arabia and limited access to the open ocean imposes several challenges to the expansion and sustainability of solar-powered desalination plants. For example, the frequent and intense dust storms that occur in the region can degrade solar panels and significantly reduce their efficiency. Moreover, the high salinity Arabian Gulf is both the source of feedwater and sink of hypersaline discharge (brine) for many plants in the east of the Kingdom, and the brine may alter the salinity, temperature and movement of the water thereby reducing the quality of the feedwater to the desalination plants. Here, we propose a framework to investigate the different interactions between climate, dust, solar power generation and seawater desalination in order to identify optimal parameters such as locations of solar panels and seawater intake for sustainable implementation of solar-powered desalination plants. This framework integrates several numerical models including regional climate, hydrodynamics, Photovoltaics (PV) and Photovoltaic-Reverse Osmosis (PV-RO) models that are used to investigate these interactions for a solar-powered desalination plant at AlKhafji on the Northeastern coast of Saudi Arabia.

  6. A Parametric Empirical Bayesian framework for the EEG/MEG inverse problem: generative models for multisubject and multimodal integration

    Directory of Open Access Journals (Sweden)

    Richard N Henson

    2011-08-01

    Full Text Available We review recent methodological developments within a Parametric Empirical Bayesian (PEB framework for reconstructing intracranial sources of extracranial electroencephalographic (EEG and magnetoencephalographic (MEG data under linear Gaussian assumptions. The PEB framework offers a natural way to integrate multiple constraints (spatial priors on this inverse problem, such as those derived from different modalities (e.g., from functional magnetic resonance imaging, fMRI or from multiple replications (e.g., subjects. Using variations of the same basic generative model, we illustrate the application of PEB to three cases: 1 symmetric integration (fusion of MEG and EEG; 2 asymmetric integration of MEG or EEG with fMRI, and 3 group-optimisation of spatial priors across subjects. We evaluate these applications on multimodal data acquired from 18 subjects, focusing on energy induced by face perception within a time-frequency window of 100-220ms, 8-18Hz. We show the benefits of multi-modal, multi-subject integration in terms of the model evidence and the reproducibility (over subjects of cortical responses to faces.

  7. Task 4.1: Development of a framework for creating a databank to generate probability density functions for process parameters

    International Nuclear Information System (INIS)

    Burgazzi, Luciano

    2011-01-01

    PSA analysis should be based on the best available data for the types of equipment and systems in the plant. In some cases very limited data may be available for evolutionary designs or new equipments, especially in the case of passive systems. It has been recognized that difficulties arise in addressing the uncertainties related to the physical phenomena and characterizing the parameters relevant to the passive system performance evaluation, since the unavailability of a consistent operational and experimental data base. This lack of experimental evidence and validated data forces the analyst to resort to expert/engineering judgment to a large extent, thus making the results strongly dependent upon the expert elicitation process. This prompts the need for the development of a framework for constructing a database to generate probability distributions for the parameters influencing the system behaviour. The objective of the task is to develop a consistent framework aimed at creating probability distributions for the parameters relevant to the passive system performance evaluation. In order to achieve this goal considerable experience and engineering judgement are also required to determine which existing data are most applicable to the new systems or which generic data bases or models provide the best information for the system design. Eventually in case of absence of documented specific reliability data, documented expert judgement coming out from a well structured procedure could be used to envisage sound probability distributions for the parameters under interest

  8. Developing a Theoretical Framework Using a Nursing Perspective to Investigate Perceived Health in the "Sandwich Generation" Group.

    Science.gov (United States)

    Oulevey Bachmann, Annie; Danuser, Brigitta; Morin, Diane

    2015-10-01

    Coexisting workloads from professional, household and family, and caregiving activities for frail parents expose middle-aged individuals, the so-called "Sandwich Generation", to potential health risks. Current trends suggest that this situation will continue or increase. Thus SG health promotion has become a nursing concern. Most existing research considers coexisting workloads a priori pathogenic. Most studies have examined the association of one, versus two, of these three activities with health. Few studies have used a nursing perspective. This article presents the development of a framework based on a nursing model. We integrated Siegrist's Effort-Reward Imbalance middle-range theory into "Neuman Systems Model". The latter was chosen for its salutogenic orientation, its attention to preventive nursing interventions and the opportunity it provides to simultaneously consider positive and negative perceptions of SG health and SG coexisting workloads. Finally, it facilitated a theoretical identification of health protective factors. © The Author(s) 2015.

  9. Risk perception & strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy.

    Energy Technology Data Exchange (ETDEWEB)

    Brewer, Jeffrey D.

    2005-11-01

    The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate the wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system.

  10. Explicit polarization: a quantum mechanical framework for developing next generation force fields.

    Science.gov (United States)

    Gao, Jiali; Truhlar, Donald G; Wang, Yingjie; Mazack, Michael J M; Löffler, Patrick; Provorse, Makenzie R; Rehak, Pavel

    2014-09-16

    Conspectus Molecular mechanical force fields have been successfully used to model condensed-phase and biological systems for a half century. By means of careful parametrization, such classical force fields can be used to provide useful interpretations of experimental findings and predictions of certain properties. Yet, there is a need to further improve computational accuracy for the quantitative prediction of biomolecular interactions and to model properties that depend on the wave functions and not just the energy terms. A new strategy called explicit polarization (X-Pol) has been developed to construct the potential energy surface and wave functions for macromolecular and liquid-phase simulations on the basis of quantum mechanics rather than only using quantum mechanical results to fit analytic force fields. In this spirit, this approach is called a quantum mechanical force field (QMFF). X-Pol is a general fragment method for electronic structure calculations based on the partition of a condensed-phase or macromolecular system into subsystems ("fragments") to achieve computational efficiency. Here, intrafragment energy and the mutual electronic polarization of interfragment interactions are treated explicitly using quantum mechanics. X-Pol can be used as a general, multilevel electronic structure model for macromolecular systems, and it can also serve as a new-generation force field. As a quantum chemical model, a variational many-body (VMB) expansion approach is used to systematically improve interfragment interactions, including exchange repulsion, charge delocalization, dispersion, and other correlation energies. As a quantum mechanical force field, these energy terms are approximated by empirical functions in the spirit of conventional molecular mechanics. This Account first reviews the formulation of X-Pol, in the full variationally correct version, in the faster embedded version, and with systematic many-body improvements. We discuss illustrative examples

  11. GLUE Analysis and Optimal Operation for Diyala River Basin in Iraq Using Variable Infiltration Capacity Model

    Science.gov (United States)

    Waheed, S., Sr.; Ramirez, J.

    2017-12-01

    Uncertainty in both hydrologic behavior and model characterization is a concern for current and future water resource system planning, operation, and management. To develop optimal dam operation schemes under future uncertainty, the sensitivity of the precipitation-runoff response to changes in hydro-climatic forcing must be quantified. To achieve this purpose, accurate (observational and modeled) data should be implemented. Herein, many data sources were compared to representative hydrologic datasets. Due to limited availability of observed daily data, a random temporal cascade method was used to downscale the monthly precipitation into daily. Then, four interpolation methods were compared to transform the point into gridded data. Furthermore, a regression technique coupled with Kriging method was developed. The method is based on regressing modeled data (from VIC dataset) with the observed gridded temperature by relating the regression to the geometry of each grid. The sensitivity and identifiability of the Variable Infiltration Capacity model (VIC) for the Diyala River basin in Iraq were evaluated using GLUE technique. Diyala River is a Tigris River tributary in eastern Iraq. Its total length and basin area are about 216.5 km and 16,763.7 km2, respectively. Seven candidate parameters of VIC model (b_infilt, Ds, Ws, Dsmax, and depths of soil layer 1, 2, and 3) associated with the infiltration and surface runoff production processes are examined for 14000 random sets. The comparison between the different data showed that neither the observations from Tropical Rainfall Measurement Mission nor the VIC modeled data is accurate for gridded precipitation; therefore, a downscaling technique was applied. Moreover, the comparison between four different interpolation techniques revealed that the Kriging method is the most accurate. The optimal model performance was found to be 0.731 NSCE. Also, the GLUE analysis results implied that the depth of the second soil layer depth

  12. Highly Stretchable, Biocompatible, Striated Substrate Made from Fugitive Glue

    Directory of Open Access Journals (Sweden)

    Wei Li

    2015-06-01

    Full Text Available We developed a novel substrate made from fugitive glue (styrenic block copolymer that can be used to analyze the effects of large strains on biological samples. The substrate has the following attributes: (1 It is easy to make from inexpensive components; (2 It is transparent and can be used in optical microscopy; (3 It is extremely stretchable as it can be stretched up to 700% strain; (4 It can be micro-molded, for example we created micro-ridges that are 6 μm high and 13 μm wide; (5 It is adhesive to biological fibers (we tested fibrin fibers, and can be used to uniformly stretch those fibers; (6 It is non-toxic to cells (we tested human mammary epithelial cells; (7 It can tolerate various salt concentrations up to 5 M NaCl and low (pH 0 and high (pH 14 pH values. Stretching of this extraordinary stretchable substrate is relatively uniform and thus, can be used to test multiple cells or fibers in parallel under the same conditions.

  13. From glue to gasoline: how competition turns perspective takers unethical.

    Science.gov (United States)

    Pierce, Jason R; Kilduff, Gavin J; Galinsky, Adam D; Sivanathan, Niro

    2013-10-01

    Perspective taking is often the glue that binds people together. However, we propose that in competitive contexts, perspective taking is akin to adding gasoline to a fire: It inflames already-aroused competitive impulses and leads people to protect themselves from the potentially insidious actions of their competitors. Overall, we suggest that perspective taking functions as a relational amplifier. In cooperative contexts, it creates the foundation for prosocial impulses, but in competitive contexts, it triggers hypercompetition, leading people to prophylactically engage in unethical behavior to prevent themselves from being exploited. The experiments reported here establish that perspective taking interacts with the relational context--cooperative or competitive--to predict unethical behavior, from using insidious negotiation tactics to materially deceiving one's partner to cheating on an anagram task. In the context of competition, perspective taking can pervert the age-old axiom "do unto others as you would have them do unto you" into "do unto others as you think they will try to do unto you."

  14. PHP frameworks

    OpenAIRE

    Srša, Aljaž

    2016-01-01

    The thesis presents one of the four most popular PHP web frameworks: Laravel, Symfony, CodeIgniter and CakePHP. These frameworks are compared with each other according to the four criteria, which can help with the selection of a framework. These criteria are size of the community, quality of official support, comprehensibility of framework’s documentation and implementation of functionalities in individual frameworks, which are automatic code generation, routing, object-relational mapping and...

  15. Cross-Layer Framework for Fine-Grained Channel Access in Next Generation High-Density WiFi Networks

    Institute of Scientific and Technical Information of China (English)

    ZHAO Haitao; ZHANG Shaojie; Emiliano Garcia-Palacios

    2016-01-01

    Densely deployed WiFi networks will play a crucial role in providing the capacity for next generation mobile internet.However,due to increasing interference,overlapped channels in WiFi networks and throughput efficiency degradation,densely deployed WiFi networks is not a guarantee to obtain higher throughput.An emergent challenge is how to efficiently utilize scarce spectrum resources,by matching physical layer resources to traffic demand.In this aspect,access control allocation strategies play a pivotal role but remain too coarse-grained.As a solution,this research proposes a flexible framework for fine-grained channel width adaptation and multi-channel access in WiFi networks.This approach,named SFCA (Subcarrier Fine-grained Channel Access),adopts DOFDM (Discontinuous Orthogonal Frequency Division Multiplexing) at the PHY layer.It allocates the frequency resource with a subcarrier granularity,which facilitates the channel width adaptation for multi-channel access and thus brings more flexibility and higher frequency efficiency.The MAC layer uses a frequencytime domain backoff scheme,which combines the popular time-domain BEB scheme with a frequency-domain backoff to decrease access collision,resulting in higher access probability for the contending nodes.SFCA is compared with FICA (an established access scheme) showing significant outperformance.Finally we present results for next generation 802.11 ac WiFi networks.

  16. First e⁻/γ Commissioning Results for the GlueX Experiment/Hall D at CEBAF

    Energy Technology Data Exchange (ETDEWEB)

    McCaughan, Michael D. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Satogata, Todd J. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Roblin, Yves R. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Benesch, Jay F. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

    2015-09-01

    Experimental Hall D, with flagship experiment GlueX, was constructed as part of the 12 GeV CEBAF upgrade. A new magnetically extracted electron beam line was installed to support this hall. Bremsstrahlung photons from retractable radiators are delivered to the experiment through a series of collimators following a long drift to allow for beam convergence. Coherent Bremsstrahlung generated by interaction with a diamond radiator will achieve a nominal 40% linear polarization and photon energies between 8.5 and 9 GeV from 12.1 GeV electrons, which are then tagged or diverted to a medium power 60kW electron dump. The expected photon flux is 107-108 Hz. This paper discusses the experimental line design, commissioning experience gained since first beam in spring 2014, and the present results of beam commissioning by the experiment.

  17. Fibrin glue as a protective tool for microanastomoses in limb reconstructive surgery

    Directory of Open Access Journals (Sweden)

    Langer, Stefan

    2015-12-01

    Full Text Available Aim: Fibrin glue becomes a more and more routinely used tool for stabilization of microanastomoses and nerve repair. This paper summarizes the technical properties and advantages of its use in a wide variety of microsurgical contexts, and includes an exemplary limb reconstructive case.Patients and methods: A total of 131 patients who had undergone elective and emergency microsurgery mainly of the limbs were retrospectively analyzed, as was the use of free flaps.Results: The use of fibrin glue allows for proper positioning of anastomoses and repaired nerves. No torsion of the pedicle could be seen. The flap survival rated >94%. The fibrin glue could stay in place in >99%. In the rare case of revision, the fibrin glue could easily be removed without damaging the region of the microanastomosis.Conclusion: Fibrin glue should not be used to repair insufficient, i.e., leaking anastomoses, but it does protect the site of anastomosis from tissue and fluid pressure. It prevents the pedickle from torsion and its use facilitates relocation of the microanastomoses in cases of revision surgery.

  18. Glue detection based on teaching points constraint and tracking model of pixel convolution

    Science.gov (United States)

    Geng, Lei; Ma, Xiao; Xiao, Zhitao; Wang, Wen

    2018-01-01

    On-line glue detection based on machine version is significant for rust protection and strengthening in car production. Shadow stripes caused by reflect light and unevenness of inside front cover of car reduce the accuracy of glue detection. In this paper, we propose an effective algorithm to distinguish the edges of the glue and shadow stripes. Teaching points are utilized to calculate slope between the two adjacent points. Then a tracking model based on pixel convolution along motion direction is designed to segment several local rectangular regions using distance. The distance is the height of rectangular region. The pixel convolution along the motion direction is proposed to extract edges of gules in local rectangular region. A dataset with different illumination and complexity shape stripes are used to evaluate proposed method, which include 500 thousand images captured from the camera of glue gun machine. Experimental results demonstrate that the proposed method can detect the edges of glue accurately. The shadow stripes are distinguished and removed effectively. Our method achieves the 99.9% accuracies for the image dataset.

  19. The Effect of Seaweed Glue in the Separation of Copper–Molybdenum Sulphide Ore by Flotation

    Directory of Open Access Journals (Sweden)

    Zhixiang Chen

    2018-01-01

    Full Text Available Flotation separation of chalcopyrite from molybdenite was studied using seaweed glue (SEG as a depressant. Flotation process and mechanism were examined by response surface methodology, flotation tests, adsorption tests, zeta potential measurements and fourier transform infrared (FT-IR spectra. Response surface methodology with a Box–Behnken design suggested the optimal reagent schedule: pH 4, depressant seaweed glue 197 mg/L, collector amyl xanthate 16 mg/L and frother (methyl isobutyl carbinol 20 mg/L, and selective separation of chalcopyrite and molybdenite was achieved by flotation. Comparison of SEG and traditional depressants indicated that the SEG could achieve a similar separation efficiency, and exhibited the advantages of environmental compatibility and economic adaptability. Co-adsorption of seaweed glue and amyl xanthate occurred on the surface of molybdenite, and is explained to happen through distinct mechanisms due to the heterogeneous nature of the surface. It is likely that seaweed glue depresses molybdenite by covering the dixanthogen resulting from adsorption of xanthate ions. It is shown that seaweed glue is as effective a depressant of Cu/Mo separation as cyanide.

  20. SHEAR STRENGTH IN THE GLUE LINE OF Eucalyptus sp. AND Pinus sp.WOOD

    Directory of Open Access Journals (Sweden)

    Juliana Jerásio Bianche

    Full Text Available ABSTRACT To evaluate the adhesive efficiency on the union of glued joints in a particular temperature and humidity conditions for a specified time the adhesive must be submitted to specific load tests, such as shear in the glue line. The objective of this study was to evaluate the shear strength in the glue line of Eucalyptus sp and Pinus sp.woods. Five adhesives (castor oil, sodium silicate, modified silicate, , PVA and resorcinol-formaldehyde, three weights (150 g/m2, 200 g/m2, and 250 g/m2 and two species (Eucalyptus sp. and Pinus sp. of wood were used. Twelve specimens were obtained from each repetition per treatment, corresponding to 108 specimens that were conditioned at a temperature of 23 ± 1°C and relative humidity of 50 ± 2%. The interaction between the weight and type of adhesive was significant for the shear strength in the glue line of eucalyptus wood. However, no interaction between the weight and the adhesive was found for pinus, only the isolated from the adhesive effect. Chemical bonds originated in the polymerization of resorcinol-formaldehyde adhesives and castor bi-component conferred upon these adhesives the greatest resistance in the glue line. Castor and resorcinol-formaldehyde adhesives showed the highest shear strength values in the line of glue and wood failure. Castor adhesive presented satisfactory performance for bonding of eucalyptus and pine woods.

  1. Institutional Governance Framework for Determining Carbon-related Accounting Practices: An Exploratory Study of Electricity Generating Companies in Malaysia

    Science.gov (United States)

    Alrazi, B.; Mat Husin, N.

    2016-03-01

    Electricity industry is the major contributor of the global carbon emissions which has been scientifically identified as the main cause of climate change. With the various initiatives being implemented at the international, national, and industry levels, companies in the electricity industry are currently facing immense pressure from various stakeholders to demonstrate their policies, initiatives, targets, and performance on climate change. Against this background, accounting system is argued to be able to be play important roles in combating climate change. Using institutional governance as the underlying framework, we have identified several governance mechanisms as the determining factors for companies to have a systematic accounting system related to carbon emissions. The factors include environmental management system certification, environmental organization, publication of stand-alone sustainability reports, the use of GRI guidelines, environmental strategic planning, governance quality, and participation in CDP surveys and emissions trading scheme. We explored this issue in the context of major electricity generating companies in Malaysia and found that except for certified environmental management system, the other governance mechanisms are still lacking. The findings suggest that companies in Malaysia, in particular, from the electricity industry are not well prepared in facing risks related to climate change.

  2. A segmentation framework towards automatic generation of boost subvolumes for FDG-PET tumors: A digital phantom study

    International Nuclear Information System (INIS)

    Yang, Fei; Grigsby, Perry W.

    2012-01-01

    Potential benefits of administering nonuniform radiation dose to heterogeneous tumors imaged with FDG-PET have been widely demonstrated; whereas the number of discrete dose levels to be utilized and corresponding locations for prescription inside tumors vary significantly with current existing methods. In this paper, an automated and unsupervised segmentation framework constituted mainly by an image restoration mechanism based on variational decomposition and a voxel clustering scheme based on spectral clustering was presented towards partitioning FDG-PET imaged tumors into subvolumes characterized with the total intra-subvolume activity similarity and the total inter-subvolume activity dissimilarity being simultaneously maximized. Experiments to evaluate the proposed system were carried out with using FDG-PET data generated from a digital phantom that employed SimSET (Simulation System for Emission Tomography) to simulate PET acquisition of tumors. The obtained results show the feasibility of the proposed system in dividing FDG-PET imaged tumor volumes into subvolumes with intratumoral heterogeneity being properly characterized, irrespective of variation in tumor morphology as well as diversity in intratumoral heterogeneity pattern.

  3. Clinical and morphological evaluation of snake venom derived fibrin glue on the tendon healing in dogs

    Directory of Open Access Journals (Sweden)

    G. C. Ferraro

    2005-12-01

    Full Text Available The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the healing of the deep digital flexor tendon, during three periods. The tendon of the 2nd digit of 30 thoracic limbs of dogs was partially sectioned for glue application. Biopsies were performed 7, 15, and 30 days post surgery for the clinical and morphological study of tendons. Analysis of the results showed that 73.3% of the tendons showed stump retraction and 16.6% moderate to excessive adherence, which affected sliding. There was a significant difference in the number of inflammatory cells among the three studied periods, being the highest on day 15. The morphological analysis revealed a typical tendon healing process with a lower level of inflammation in the acute phase, facilitating the cicatricial maturation phase. Snake venom derived fibrin glue promotes the healing in dog flexor tendon.

  4. Photoclickable dendritic molecular glue: noncovalent-to-covalent photochemical transformation of protein hybrids.

    Science.gov (United States)

    Uchida, Noriyuki; Okuro, Kou; Niitani, Yamato; Ling, Xiao; Ariga, Takayuki; Tomishige, Michio; Aida, Takuzo

    2013-03-27

    A water-soluble dendron with a fluorescein isothiocyanate (FITC) fluorescent label and bearing nine pendant guanidinium ion (Gu(+))/benzophenone (BP) pairs at its periphery (Glue(BP)-FITC) serves as a "photoclickable molecular glue". By multivalent salt-bridge formation between Gu(+) ions and oxyanions, Glue(BP)-FITC temporarily adheres to a kinesin/microtubule hybrid. Upon subsequent exposure to UV light, this noncovalent binding is made permanent via a cross-linking reaction mediated by carbon radicals derived from the photoexcited BP units. This temporal-to-permanent transformation by light occurs quickly and efficiently in this preorganized state, allowing the movements of microtubules on a kinesin-coated glass plate to be photochemically controlled. A fundamental difference between such temporal and permanent bindings was visualized by the use of "optical tweezers".

  5. Using the DP-190 glue for adhesive attachment of a large space mirror and its rim

    Science.gov (United States)

    Vlasenko, Oleg; Zverev, Alexey; Sachkov, Mikhail

    2014-07-01

    The glue DP-190 is widely used for adhesive attachment of astrositall (zerodur) lightweight large-size space astronomical mirrors (diameter of 1.7 m and more) with elements of their frames of invar. Peculiarities of physicalmechanical behavior of the glue DP-190 when exposed to the environment during the ground operation and in orbit cause instability of the reflective surface quality of mirrors. In this report we show that even a small (around 1%-5%) volumetric deformation of a cylindrical adhesive layer with a thickness of 0.8 mm between the mirror and the rim element causes significant mirrors deformation. We propose to use adhesive layer of special form that allows to reduce volumetric deformations of the glue DP-190 up to three times. Here we present results based on primary mirror tests of the WSO-UV project.

  6. Clinical experience of intrapleural administration of fibrin glue for secondary pneumothorax with advanced lung cancer

    International Nuclear Information System (INIS)

    Nishino, Takeshi; Takizawa, Hiromitsu; Yoshida, Mitsuteru; Kawakami, Yukikiyo; Sakiyama, Shoji; Kondo, Kazuya

    2014-01-01

    Secondary pneumothorax with advanced lung cancer is an intractable and serious pathosis, which directly aggravates patients' Quality of Life (QOL) and prognosis. We first select the intrapleural administration of fibrin glue for secondary pneumothorax with advanced lung cancer. From April 2009 to May 2012, we encountered 5 patients who developed secondary pneumothorax during treatment for advanced lung cancer. Their average age was 60.8 years old, and 4 of them had squamous cell carcinoma, 1 had adenocarcinoma, and all had unresectable advanced lung cancer. In 4 of them, the point of air leakage could be detected by pleurography, and leakage could be stopped by the intrapleural administration of fibrin glue. All of them could receive chemotherapy or radiotherapy after treatment for secondary pneumothorax. The intrapleural administration of fibrin glue may be an effective and valid treatment for intractable secondary pneumothorax with advanced lung cancer. (author)

  7. Successful Endoscopic Management of Non-Healing Perforated Duodenal Ulcer with Polyglycolic Acid Sheet and Fibrin Glue.

    Science.gov (United States)

    Mishiro, Tsuyoshi; Shibagaki, Kotaro; Matsuda, Kayo; Fukuyama, Chika; Okada, Mayumi; Mikami, Hironobu; Izumi, Daisuke; Yamashita, Noritsugu; Okimoto, Eiko; Fukuda, Naoki; Aimi, Masahito; Fukuba, Nobuhiko; Oshima, Naoki; Takanashi, Toshihiro; Matsubara, Takeshi; Ishimura, Norihisa; Ishihara, Shunji; Kinoshita, Yoshikazu

    2016-08-01

    In recent years, treatment techniques in which polyglycolic acid sheets are applied to various situations with fibrin glue have exhibited great clinical potential, and previous studies have reported safety and efficacy. We describe closure of a non-healing perforated duodenal ulcer with the use of a polyglycolic acid sheet and fibrin glue in an elderly patient who was not a candidate for surgery.

  8. Determination of fibrin glue with antibiotics on collagen production in colon anastomosis

    Directory of Open Access Journals (Sweden)

    Stanojković Zoran

    2008-01-01

    Full Text Available Background/Aim. Fibrin glue is used as a matrix for local application of antibiotics. The aim of this study was to determine whether application of fibrin glue in combination with antibiotics can strengthen collagen production, prevent dehiscence of colon anastomoses due to infection, and reduce frequency of mortality and morbidity comparing to the control group and the group with fibrin glue application. Methods. The adult male Wistar rats divided into three groups were used in the experiment. The group 1 was the control one (after partial colon resection, colonic anastomoses performed were not treated, while to the group 2 and the group 3 were applied fibrin glue and fibrin glue with antibiotics (clindamycin and ceftriaxon on the site of anastomoses, respectively. Quality of colonic anastomoses were estimated by means of determination of collagen (L-hydroxyproline amount in the collon wall with anastomoses and histological analysis of this colon segment using light and electronic microscope on the days 5, 7 and 13 postoperatively. Results. The highest morbidity rate was registered in the group 1 (30%, then in the group 2 (13.3% and the lowest one in the group 3 (3.33%; p < 0,05 vs group 1. Mortality rate was significantly higher in the group 1 than in the group 3 (20% and 0%, respectively; p < 0,05. In the postoperative course, the highest concentrations of collagen in the colon wall on the site of anastomoses, which was confirmed by both light and electronic microscopy, were found in the group 3. Conclusion. The application of fibrin glue with antibiotics on colon anastomoses reduces the number of dehiscence, provides good mechanical protection and shorten the time of anastomoses healing.

  9. BioGlue iceball stabilization to minimize the risk of hemorrhage during laparoscopic renal cryoablation.

    Science.gov (United States)

    Mues, Adam C; Graversen, Joseph A; Truesdale, Matthew D; Casazza, Cristin; Landman, Jaime

    2011-08-01

    To evaluate the application of a BioGlue adhesive shell to minimize iceball fracture. Iceball fracture and hemorrhage is common with laparoscopic cryoablation (LCA) of larger (>4 cm) renal tumors. Twenty large iceballs were created in porcine kidneys using 3 cryoablation probes in a nonsurvival study. Each kidney underwent an upper and lower pole ablation. One pole in each kidney was covered with 5 mL of BioGlue and the opposite pole served as a control. A double freeze-thaw cycle was performed (10 minutes freeze and 5 minutes active thaw) in both renal poles simultaneously. The probes were removed and the sites were monitored for 20 minutes under direct vision. Fracture length (mm), severity of fracture depth, severity of bleeding (absent, mild, moderate, severe), and estimated blood loss (EBL) (mL) were recorded. In the control group, the mean fracture length was 1.9 mm (range, 0-3 mm). Blood loss was absent in 10%, mild in 60%, and moderate in 30% of ablations. The mean EBL was 20.5 mL (range, 0-50 mL). For the BioGlue ablations, there were no parenchymal fractures. Blood loss was mild in 30% and absent in 70% of sites with an average EBL of 5 mL (range, 0-20). Two bleeding sites occurred as a result of subcapsular hematomas caused by initial probe placement. BioGlue application minimized the frequency and magnitude of renal fracture. EBL was lower with BioGlue application and most sites demonstrated no postablation bleeding. Further clinical study of the BioGlue shell should be performed to confirm these results. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Evaluation of a feature extraction framework for FPGA firmware generation during a beam-test at CERN-SPS for the CBM-TRD experiment

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Chavez, Cruz de Jesus; Munoz Castillo, Carlos Enrique; Kebschull, Udo [Infrastructure and Computer Systems in Data Processing (IRI), Goethe University, Frankfurt am Main (Germany); Collaboration: CBM-Collaboration

    2016-07-01

    A feature extraction framework has been developed to allow easy FPGA firmware generation for specific feature extraction algorithms in order to find and extract regions of interest within time-based signals. This framework allows the instantiation of multiple well-known feature extraction algorithms such as center of gravity, time over threshold and cluster finder, just to mention a few of them. A graphical user interface has also been built on top of the framework to provide a user-friendly way to visualize the data-flow architecture across processing stages. The FPGA platform constraints are automatically set up by the framework itself. This feature reduces the need of low-level hardware configuration knowledge that would normally be provided by the user, centering the attention in setting up the processing algorithms for the given task more than in writing hardware description code. During November 2015, a beam-test was performed at the CERN-SPS hall. The presented framework was used to generate a firmware for the SysCore3 FPGA development board used to readout two TRD detectors by means of the SPADIC 1.0 front-end chip. The framework architecture, design methodology, as well as the achieved results during the mentioned beam-test are presented.

  11. GLUE 2 deployment: Ensuring quality in the EGI/WLCG information system

    International Nuclear Information System (INIS)

    Burke, Stephen; Pradillo, Maria Alandes; Field, Laurence; Keeble, Oliver

    2014-01-01

    The GLUE 2 information model is now fully supported in the production EGI/WLCG information system. However, to make it usable and allow clients to rely on the published information it is important that the meaning is clearly defined, and that information providers and site configurations are validated to ensure as far as possible that what they publish is correct. In this paper we describe the definition of a detailed schema usage profile, the implementation of a software tool to validate published information according to the profile and the use of the tool in the production Grid, and also summarise the overall state of GLUE 2 deployment.

  12. Glue from the Sea:Biomedical Adhesives Inspired by Algal Polymers

    Institute of Scientific and Technical Information of China (English)

    H.Bianco-Peled; R.Bitton; P.Potin

    2007-01-01

    1 Introduction Tissue repair following surgery or trauma has been dominated by sutures,staples and wiring.Although these techniques are well established and widely used,their application often involves pain,unaesthetic results,or bleeding. These limitations emphasize the need for adhesive products to be available to surgeons.2 ResultsA challenging aspect of developing new tissue adhesive is to create a material that can glue wet surfaces.The success of synthetic glues under such an environment is very ...

  13. Nuovi Metodi di visualizzazione geografica: l'approccio Focus+Glue+Context

    Directory of Open Access Journals (Sweden)

    Flavio Lupia

    2010-03-01

    Full Text Available New cartographic visualization methods:the Focus+Glue+Context approachFocus+Glue+Context is a new cartographic visualization method specifically designed to solve the fruition problems connected with the use of mobile devices and web mapping services. The objective of the F+G+C approach is to reduce users cognitive efforts when reading a map: to do so, the area of interest is ‘highlighted’ in a lower and more detailed scale through a fisheye lens effect, while the sorrouding context, useful to the user to determine the items relationships in a map, is maintained on a higher scale.

  14. Nuovi Metodi di visualizzazione geografica: l'approccio Focus+Glue+Context

    Directory of Open Access Journals (Sweden)

    Flavio Lupia

    2010-03-01

    Full Text Available New cartographic visualization methods: the Focus+Glue+Context approach Focus+Glue+Context is a new cartographic visualization method specifically designed to solve the fruition problems connected with the use of mobile devices and web mapping services. The objective of the F+G+C approach is to reduce users cognitive efforts when reading a map: to do so, the area of interest is ‘highlighted’ in a lower and more detailed scale through a fisheye lens effect, while the sorrouding context, useful to the user to determine the items relationships in a map, is maintained on a higher scale.

  15. Bandwidth-Tunable Fiber Bragg Gratings Based on UV Glue Technique

    Science.gov (United States)

    Fu, Ming-Yue; Liu, Wen-Feng; Chen, Hsin-Tsang; Chuang, Chia-Wei; Bor, Sheau-Shong; Tien, Chuen-Lin

    2007-07-01

    In this study, we have demonstrated that a uniform fiber Bragg grating (FBG) can be transformed into a chirped fiber grating by a simple UV glue adhesive technique without shifting the reflection band with respect to the center wavelength of the FBG. The technique is based on the induced strain of an FBG due to the UV glue adhesive force on the fiber surface that causes a grating period variation and an effective index change. This technique can provide a fast and simple method of obtaining the required chirp value of a grating for applications in the dispersion compensators, gain flattening in erbium-doped fiber amplifiers (EDFAs) or optical filters.

  16. Photocurable surgical tissue adhesive glues composed of photoreactive gelatin and poly(ethylene glycol) diacrylate.

    Science.gov (United States)

    Nakayama, Y; Matsuda, T

    1999-01-01

    This article presents a novel photochemically driven surgical tissue adhesive technology using photoreactive gelatins and a water-soluble difunctional macromer (poly(ethylene glycol) diacrylate: PEGDA).The gelatins were partially derivatized with photoreactive groups, such as ultraviolet light (UV)-reactive benzophenone and visible light-reactive xanthene dye (e.g., fluorescein sodium salt, eosin Y, and rose bengal). A series of the prepared photocurable tissue adhesive glues, consisting of the photoreactive gelatin, PEGDA, and a saline solution with or without ascorbic acid as a reducing agent, were viscous solutions under warming, and their effectiveness was evaluated as hemostasis- and anastomosis-aid in cardiovascular surgery. Regardless of the type of photoreactive groups, the irradiation of the photocurable tissue adhesive glues by UV or visible light within 1 min produced water-swollen gels, which had a high adhesive strength to wet collagen film. These were due to the synergistic action of photoreactive group-initiated photo-cross-linking and photograft polymerization. An increase in the irradiation time resulted in increased gel yield and reduced water swellability. A decrease in the molecular weight of PEGDA and an increase in concentration of both gelatin and PEGDA resulted in reduced water swellability and increased tensile and burst strengths of the resultant gels. In rats whose livers were injured with a trephine in laparotomy, the bleeding spots were coated with the photocurable adhesive glue and irradiated through an optical fiber. The coated solution was immediately converted to a swollen gel. The gel was tightly adhered to the liver tissue presumably by interpenetration, and concomitantly hemostasis was completed. The anastomosis treatment with the photocurable glue in the canine abdominal or thoracic aortas incised with a knife resulted in little bleeding under pulsatile flow after declamping. Histological examination showed that the glues

  17. Effect of BioGlue on the incidence of pancreatic fistula following pancreas resection.

    Science.gov (United States)

    Fisher, William E; Chai, Christy; Hodges, Sally E; Wu, Meng-Fen; Hilsenbeck, Susan G; Brunicardi, F Charles

    2008-05-01

    Despite numerous modifications of surgical technique, pancreatic fistula remains a serious problem and occurs in about 10% of patients following pancreas resection. BioGlue is a new sealant that creates a flexible mechanical seal within minutes independent of the body's clotting mechanism. Application of BioGlue sealant will reduce the incidence of pancreatic fistula following pancreas resection. A retrospective cohort study was performed with 64 patients undergoing pancreas resection. BioGlue sealant was applied to the pancreatic anastomosis (Whipple) or resection margin (distal pancreatectomy) in 32 cases. Factors that could affect the rate of postoperative pancreatic fistula were recorded. Pancreatic fistula was defined as greater than 50 ml of drain output with an amylase content greater than three times normal serum value after postoperative day 10. To improve the sensitivity of our study, we also examined pancreatic fistula with a strict definition of any drain output on or after postoperative day 3 with a high amylase content and graded the fistulas in terms of clinical severity. Grade A leaks were defined as subclinical. Grade B leaks required some response such as making the patient nil per os, parenteral nutrition, octreotide, antibiotics, or a prolonged hospital stay. Grade C leaks were defined as serious and life threatening. They were associated with hemorrhage, sepsis, resulted in deterioration of other organ systems, and mandated intensive care. Comparisons between the two groups were made using the chi-square test or Fisher's exact test for categorical variables and by the Wilcoxon rank-sum test for continuous variables. P values of 0.05 or less were deemed statistically significant. There were no differences between the patients who received BioGlue and the control cohort in terms of comorbid conditions, tumor location, texture of the pancreas, size of the pancreatic duct, or surgical technique. By the common definition, pancreatic fistula occurred

  18. Context-aware System Service Call-oriented Symbolic Execution of Android Framework with Application to Exploit Generation

    OpenAIRE

    Luo, Lannan; Zeng, Qiang; Cao, Chen; Chen, Kai; Liu, Jian; Liu, Limin; Gao, Neng; Yang, Min; Xing, Xinyu; Liu, Peng

    2016-01-01

    Android Framework is a layer of software that exists in every Android system managing resources of all Android apps. A vulnerability in Android Framework can lead to severe hacks, such as destroying user data and leaking private information. With tens of millions of Android devices unpatched due to Android fragmentation, vulnerabilities in Android Framework certainly attract attackers to exploit them. So far, enormous manual effort is needed to craft such exploits. To our knowledge, no resear...

  19. Design and Fabrication of Calibration Device for Scintillating Fibers of Tagger Microscope: For use in GlueX's QCD Experiment

    Science.gov (United States)

    Briere, Emily

    2012-10-01

    For decades, scientists have struggled to understand the chromo-electromagnetic field which confines quarks and gluons within the hadron. GlueX is a QCD experiment centered at Jefferson Lab, Virginia, seeking to better understand this gluonic field by exciting it and mapping the spectrum of exotic hybrid mesons that it generates. The experiment uses coherent bremsstrahlung radiation to produce a beam of photons, which due to their polarity act as virtual vector mesons. When incident on a liquid hydrogen target, these mesons are expected to form exotic hybrid mesons. Such particles quickly decay into new particles which are captured in a solenoid detector. The decays can then be reconstructed to examine the properties of the original exotic hybrid meson, although the initial energy of the photon is required to draw meaningful conclusions. The post-bremsstrahlung degraded electrons are bent from the main beam into the tagger microscope where they strike an array of scintillating optical fibers. Given the correlation between momentum and radial bend, the Silicon Photmultiplier sensors attached to the optical fibers are able to ``tag'' the electrons', and thus the photons', initial energies based on which fibers were hit. Providing central data for GlueX, the tagger microscope must be accurate. This paper details the design and fabrication of a scintillating fiber calibration device that moves horizontally above fiber bundles, using a green laser diode to direct light pulses into the fibers. This calibration method has been tested mechanically and via a Monte Carlo Matlab simulation, and has proven to be effective.

  20. Development and Demonstration of a Modeling Framework for Assessing the Efficacy of Using Mine Water for Thermoelectric Power Generation

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-03-01

    Thermoelectric power plants use large volumes of water for condenser cooling and other plant operations. Traditionally, this water has been withdrawn from the cleanest water available in streams and rivers. However, as demand for electrical power increases it places increasing demands on freshwater resources resulting in conflicts with other off stream water users. In July 2002, NETL and the Governor of Pennsylvania called for the use of water from abandoned mines to replace our reliance on the diminishing and sometimes over allocated surface water resource. In previous studies the National Mine Land Reclamation Center (NMLRC) at West Virginia University has demonstrated that mine water has the potential to reduce the capital cost of acquiring cooling water while at the same time improving the efficiency of the cooling process due to the constant water temperatures associated with deep mine discharges. The objectives of this project were to develop and demonstrate a user-friendly computer based design aid for assessing the costs, technical and regulatory aspects and potential environmental benefits for using mine water for thermoelectric generation. The framework provides a systematic process for evaluating the hydrologic, chemical, engineering and environmental factors to be considered in using mine water as an alternative to traditional freshwater supply. A field investigation and case study was conducted for the proposed 300 MW Beech Hollow Power Plant located in Champion, Pennsylvania. The field study based on previous research conducted by NMLRC identified mine water sources sufficient to reliably supply the 2-3,000gpm water supply requirement of Beech Hollow. A water collection, transportation and treatment system was designed around this facility. Using this case study a computer based design aid applicable to large industrial water users was developed utilizing water collection and handling principals derived in the field investigation and during previous

  1. A system-of-systems framework for the reliability analysis of distributed generation systems accounting for the impact of degraded communication networks

    International Nuclear Information System (INIS)

    Mo, Hua-Dong; Li, Yan-Fu; Zio, Enrico

    2016-01-01

    Highlights: • A system-of-systems framework is proposed for reliability analysis of DG system. • The impact of degraded communication networks is included and quantified. • Various uncertainties and contingencies in the DG system are considered. • A Monte Carlo simulation-optimal power flow computational framework is developed. • The results of the application study show the power of the proposed framework. - Abstract: Distributed generation (DG) systems install communication networks for managing real-time energy imbalance. Different from previous research, which typically assumes perfect communication networks, this work aims to quantitatively account for the impact of degraded communication networks on DG systems performance. The degraded behavior of communication networks is modeled by stochastic continuous time transmission delays and packet dropouts. On the DG systems side, we consider the inherent uncertainties of renewable energy sources, loads and energy prices. We develop a Monte Carlo simulation-optimal power flow (MCS-OPF) computational framework that is capable of generating consecutive time-dependent operating scenarios of the integrated system. Quantitative analysis is carried out to measure the impact of communication networks degradation onto the DG systems. For illustration, the framework is applied to a modified IEEE 13 nodes test feeder. The results demonstrate that the degraded communication networks can significantly deteriorate the performance of the integrated system. A grey differential model-based prediction method for reconstructing missing data is effective in mitigating the influence of the degraded communication networks.

  2. Comparative uncertainty analysis of copper loads in stormwater systems using GLUE and grey-box modeling

    DEFF Research Database (Denmark)

    Lindblom, Erik Ulfson; Madsen, Henrik; Mikkelsen, Peter Steen

    2007-01-01

    . With the proposed model and input data, the GLUE analysis show that the total sampled copper mass can be predicted within a range of +/- 50% of the median value ( 385 g), whereas the grey-box analysis showed a prediction uncertainty of less than +/- 30%. Future work will clarify the pros and cons of the two methods...

  3. Performance of fast-absorbable suture and histo-glue in closing incisions in Brown trout

    DEFF Research Database (Denmark)

    Jepsen, Niels; Larsen, Martin Hage; Aarestrup, Kim

    2017-01-01

    , growth, tag expulsion rate and incision healing was compared among three groups of dummy transmitter-tagged wild brown trout Salmo trutta where incisions were closed with two types of suture material (absorbable vs. fast absorbable) and Histo-glue. The tagged fish were kept in semi-natural ponds for 20...

  4. GLUE Based Uncertainty Estimation of Urban Drainage Modeling Using Weather Radar Precipitation Estimates

    DEFF Research Database (Denmark)

    Nielsen, Jesper Ellerbæk; Thorndahl, Søren Liedtke; Rasmussen, Michael R.

    2011-01-01

    Distributed weather radar precipitation measurements are used as rainfall input for an urban drainage model, to simulate the runoff from a small catchment of Denmark. It is demonstrated how the Generalized Likelihood Uncertainty Estimation (GLUE) methodology can be implemented and used to estimate...

  5. Magnetic Retraction of Bowel by Intraluminal Injectable Cyanoacrylate-Based Magnetic Glue

    Directory of Open Access Journals (Sweden)

    Zhigang Wang

    2013-01-01

    Full Text Available Magnetic retraction offers advantages over physical retraction by graspers because of reduced tissue trauma. The objectives of this study are to investigate a novel method of magnetisation of bowel segments by intraluminal injection of magnetic glue and to demonstrate the feasibility of magnetic retraction of bowel with sufficient force during minimal access surgery. Following an initial materials characterisation study, selected microparticles of stainless steel (SS410-μPs were mixed with chosen cyanoacrylate glue (Loctite 4014. During intraluminal injection of the magnetic glue using ex vivo porcine colonic segments, a magnetic probe placed at the injected site ensured that the SS410-μPs aggregated during glue polymerisation to form an intraluminal mucosally adherent coagulum. The magnetised colonic segments were retracted by magnetic probes (5 and 10 mm placed external to the bowel wall. A tensiometer was used to record the retraction force. With an injected volume of 2 mL in a particle concentration of 1 g/mL, this technique produced maximal magnetic retraction forces of 2.24 ± 0.23 N and 5.11 ± 0.34 N (, with use of 5 and 10 mm probes, respectively. The results indicate that the formation of an intraluminal coagulum based on SS410-μPs and Loctite 4014 produces sufficient magnetic retraction for bowel retraction.

  6. Glue-Sniffing: A Comparison Study of Sniffers and Non-Sniffers.

    Science.gov (United States)

    Jansen, P.; And Others

    1992-01-01

    Compared 22 glue sniffers and 22 nonsniffers from group of street children and adolescents living in supervised shelters. Found no statistically significant differences between groups on cognitive measures or biographical features. Shelter staff rated sniffers as significantly more disturbed in their relationships with others, although…

  7. A unique and unexplained ricochet leak post PCI – Successfully treated with intra-coronary glue

    Directory of Open Access Journals (Sweden)

    Pravin K. Goel

    2014-01-01

    Full Text Available We herein describe a unique case of coronary artery perforation treated with covered stent with repeat cardiac tamponade resulting out of a fresh unexplained leak from a remote vessel (Ricochet and successfully treated with intra-coronary injection of sterile synthetic glue, cyanoacrylate.

  8. Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue.

    NARCIS (Netherlands)

    Hallers, E.J.O. ten; Jansen, J.A.; Marres, H.A.M.; Rakhorst, G.; Verkerke, G.J.

    2007-01-01

    Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and

  9. Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue

    NARCIS (Netherlands)

    ten Hallers, E.J. Olivier; Jansen, John A.; Marres, Henri A.M.; Rakhorst, Gerhard; Verkerke, Gijsbertus Jacob

    2007-01-01

    Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and

  10. Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue

    NARCIS (Netherlands)

    ten Hallers, E. J. Olivier; Jansen, John A.; Marres, Henri A. M.; Rakhorst, Gerhard; Verkerke, Gijsbertus J.

    Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and

  11. Coronary artery narrowing after aortic root reconstruction with resorcin-formalin glue.

    Science.gov (United States)

    Martinelli, L; Graffigna, A; Guarnerio, M; Bonmassari, R; Disertori, M

    2000-11-01

    Severe stenosis of right and left main coronary artery ostia developed after aortic root reconstruction with gelatin-resorcin-formol glue for correction of acute type A aortic dissection. Surgical treatment of this condition required grafting of the right and left anterior descending arteries with bilateral mammary arteries on the beating heart.

  12. Physicochemical and functional properties, microstructure, and storage stability of whey protein/polyvinylpyrrolidone based glue sticks

    Directory of Open Access Journals (Sweden)

    Guorong Wang

    2012-11-01

    Full Text Available A glue stick is comprised of solidified adhesive mounted in a lipstick-like push-up tube. Whey is a byproduct of cheese making. Direct disposal of whey can cause environmental pollution. The objective of this study was to use whey protein isolate (WPI as a natural polymer along with polyvinylpyrrolidone (PVP to develop safe glue sticks. Pre-dissolved WPI solution, PVP, sucrose, 1,2-propanediol (PG, sodium stearate, defoamer, and preservative were mixed and dissolved in water at 90 oC and then molded in push-up tubes. Chemical composition, functional properties (bonding strength, glue setting time, gel hardness, extension/retraction, and spreading properties, microstructure, and storage stability of the prototypes were evaluated in comparison with a commercial control. Results showed that all WPI/PVP prototypes had desirable bonding strength and exhibited faster setting than PVP prototypes and control. WPI could reduce gel hardness and form less compact and rougher structures than that of PVP, but there was no difference in bonding strength. PVP and sucrose could increase the hygroscopicity of glue sticks, thus increasing storage stability. Finally, the optimized prototype GS3 (major components: WPI 8.0%, PVP 12.0%, 1,2-propanediol 10.0%, sucrose 10.0%, and stearic sodium 7.0% had a comparable functionality to the commercial control. Results indicated that whey protein could be used as an adhesive polymer for glue stick formulations, which could be used to bond fiber or cellulose derived substrates such as paper.

  13. Cross-linking by protein oxidation in the rapidly setting gel-based glues of slugs

    Science.gov (United States)

    Bradshaw, Andrew; Salt, Michael; Bell, Ashley; Zeitler, Matt; Litra, Noelle; Smith, Andrew M.

    2011-01-01

    SUMMARY The terrestrial slug Arion subfuscus secretes a glue that is a dilute gel with remarkable adhesive and cohesive strength. The function of this glue depends on metals, raising the possibility that metal-catalyzed oxidation plays a role. The extent and time course of protein oxidation was measured by immunoblotting to detect the resulting carbonyl groups. Several proteins, particularly one with a relative molecular mass (Mr) of 165×103, were heavily oxidized. Of the proteins known to distinguish the glue from non-adhesive mucus, only specific size variants were oxidized. The oxidation appears to occur within the first few seconds of secretion. Although carbonyls were detected by 2,4-dinitrophenylhydrazine (DNPH) in denatured proteins, they were not easily detected in the native state. The presence of reversible cross-links derived from carbonyls was tested for by treatment with sodium borohydride, which would reduce uncross-linked carbonyls to alcohols, but stabilize imine bonds formed by carbonyls and thus lead to less soluble complexes. Consistent with imine bond formation, sodium borohydride led to a 20–35% decrease in the amount of soluble protein with a Mr of 40–165 (×103) without changing the carbonyl content per protein. In contrast, the nucleophile hydroxylamine, which would competitively disrupt imine bonds, increased protein solubility in the glue. Finally, the primary amine groups on a protein with a Mr of 15×103 were not accessible to acid anhydrides. The results suggest that cross-links between aldehydes and primary amines contribute to the cohesive strength of the glue. PMID:21525316

  14. Fibrin glue on an aortic cusp detected by transesophageal echocardiography after valve-sparing aortic valve replacement: a case report.

    Science.gov (United States)

    Nakahira, Junko; Ishii, Hisanari; Sawai, Toshiyuki; Minami, Toshiaki

    2015-03-07

    Fibrin glue is used commonly during cardiac surgery but can behave as an intracardiac abnormal foreign body following surgery. There have been few such cases reported, and they were typically noticed only because of the resulting catastrophic cardiac conditions, such as valvular malfunction. We report a case where, for the first time, transesophageal echocardiography was used to detected fibrin glue that was adherent to the ventricular side of a patient's aortic valve immediately after aortic declamping. A 45-year-old Japanese man with Marfan syndrome underwent an aortic valve-sparing operation to treat moderate aortic valve regurgitation resulting from enlargement of his right coronary cusp. Fibrin glue was lightly applied to the suture line between the previous and new grafts. Transesophageal echocardiography performed prior to weaning from the cardiopulmonary bypass revealed mild aortic valve regurgitation in addition to a mobile membranous structure attached to the ventricular side of his aortic valve. It was identified as fibrin glue. We resolved the regurgitation by removing the fibrin glue and repeating the aortic cusp plication. The patient had no complications during recovery. Fibrin glue can act as an intracardiac foreign body and lead to a potentially fatal embolism. We demonstrated the use of transesophageal echocardiography to detect a fibrin glue-derived intracardiac abnormal foreign body and to confirm its removal. To the best of our knowledge, this is the first case where fibrin glue adherent to the aortic valve was detected by transesophageal echocardiography. These findings demonstrate the importance of using transesophageal echocardiography during cardiac surgery that involves using biological glues.

  15. Hypokalemic muscular paralysis causing acute respiratory failure due to rhabdomyolysis with renal tubular acidosis in a chronic glue sniffer.

    Science.gov (United States)

    Kao, K C; Tsai, Y H; Lin, M C; Huang, C C; Tsao, C Y; Chen, Y C

    2000-01-01

    A 34-year-old male was admitted to the emergency department with the development of quadriparesis and respiratory failure due to hypokalemia after prolonged glue sniffing. The patient was subsequently given mechanical ventilatory support for respiratory failure. He was weaned from the ventilator 4 days later after potassium replacement. Toluene is an aromatic hydrocarbon found in glues, cements, and solvents. It is known to be toxic to the nervous system, hematopoietic system, and causes acid-base and electrolyte disorders. Acute respiratory failure with hypokalemia and rhabdomyolysis with acute renal failure should be considered as potential events in a protracted glue sniffing.

  16. GSI Helmholz Centre for Heavy Ion Research - ALFA: Next generation concurrent framework for ALICE and FAIR experiments

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    FAIR is a new, unique international accelerator facility for the research with antiprotons and ions. It is being built at the GSI Darmstadt in Hesse, Germany. The commonalities between the ALICE and FAIR experiments and their computing requirements led to the development of a common software framework in an experiment independent way; ALFA (ALICE-FAIR framework). ALFA is designed for high quality parallel data processing and reconstruction on heterogeneous computing systems. It provides a data transport layer and the capability to coordinate multiple data processing components. ALFA is a flexible, elastic system which balances reliability and ease of development with performance by using a message based multi-processing in addition to multi-threading. The framework allows for usage of heterogeneous computing architectures by offloading (portions of code are accelerated on the device) or natively (where the full program is executed on the device ).

  17. Determining the hydraulic and fracture properties of the Coal Seam Gas well by numerical modelling and GLUE analysis

    Science.gov (United States)

    Askarimarnani, Sara; Willgoose, Garry; Fityus, Stephen

    2017-04-01

    Coal seam gas (CSG) is a form of natural gas that occurs in some coal seams. Coal seams have natural fractures with dual-porosity systems and low permeability. In the CSG industry, hydraulic fracturing is applied to increase the permeability and extract the gas more efficiently from the coal seam. The industry claims that it can design fracking patterns. Whether this is true or not, the public (and regulators) requires assurance that once a well has been fracked that the fracking has occurred according to plan and that the fracked well is safe. Thus defensible post-fracking testing methodologies for gas generating wells are required. In 2009 a fracked well HB02, owned by AGL, near Broke, NSW, Australia was subjected to "traditional" water pump-testing as part of this assurance process. Interpretation with well Type Curves and simple single phase (i.e. only water, no gas) highlighted deficiencies in traditional water well approaches with a systemic deviation from the qualitative characteristic of well drawdown curves (e.g. concavity versus convexity of drawdown with time). Accordingly a multiphase (i.e. water and methane) model of the well was developed and compared with the observed data. This paper will discuss the results of this multiphase testing using the TOUGH2 model and its EOS7C constitutive model. A key objective was to test a methodology, based on GLUE monte-carlo calibration technique, to calibrate the characteristics of the frack using the well test drawdown curve. GLUE involves a sensitivity analysis of how changes in the fracture properties change the well hydraulics through and analysis of the drawdown curve and changes in the cone of depression. This was undertaken by changing the native coal, fracture, and gas parameters to see how changing those parameters changed the match between simulations and the observed well drawdown. Results from the GLUE analysis show how much information is contained in the well drawdown curve for estimating field scale

  18. Strategy for assessment of WWER steam generator tube integrity. Report prepared within the framework of the coordinated research project on verification of WWER steam generator tube integrity

    International Nuclear Information System (INIS)

    2007-12-01

    Steam generator heat exchanger tube degradations happen in WWER Nuclear Power Plant (NPP). The situation varies from country to country and from NPP to NPP. More severe degradation is observed in WWER-1000 NPPs than in case of WWER-440s. The reasons for these differences could be, among others, differences in heat exchanger tube material (chemical composition, microstructure, residual stresses), in thermal and mechanical loadings, as well as differences in water chemistry. However, WWER steam generators had not been designed for eddy current testing which is the usual testing method in steam generators of western PWRs. Moreover, their supplier provided neither adequate methodology and criteria nor equipment for planning and implementing In-Service Inspection (ISI). Consequently, WWER steam generator ISI infrastructure was established with delay. Even today, there are still big differences in the eddy current inspection strategy and practice as well as in the approach to steam generator heat exchanger tube structural integrity assessment (plugging criteria for defective tubes vary from 40 to 90% wall thickness degradation). Recognizing this situation, the WWER operating countries expressed their need for a joint effort to develop methodology to establish reasonable commonly accepted integrity assessment criteria for the heat exchanger tubes. The IAEA's programme related to steam generator life management is embedded into the systematic activity of its Technical Working Group on Life Management of Nuclear Power Plants (TWG-LMNPP). Under the advice of the TWG-LMNPP, an IAEA coordinated research project (CRP) on Verification of WWER Steam Generator Tube Integrity was launched in 2001. It was completed in 2005. Thirteen organizations involved in in-service inspection of steam generators in WWER operating countries participated: Croatia, Czech Republic, Finland, France, Hungary, Russian Federation, Slovakia, Spain, Ukraine, and the USA. The overall objective was to

  19. Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs

    Directory of Open Access Journals (Sweden)

    Đenić Nebojša

    2015-01-01

    Full Text Available Background/Aim. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as a local hemostatic and as a matrix for the local dosed release of antibiotics. Antibiotics addition to fibrin glue resulted in continuous diffusion into the surrounding next 4 to 7 days. The aim of this study was to create the preconditions for gunshot wounds closing without complications by the application of fibrin glue with antibiotics 24 h after primary surgical treatment. Methods. A total of 14 pigs were wounded in the gluteofemoral region by the bullet M67, initial velocity of 720 m/s. All wounded animals were surgically treated according to the principles of the warsurgery doctrine. Seven wounds were closed with primary delayed suture four days after the primary surgical treatment (traditional approach. Fibrin glue with antibiotics was introduced in seven wounds during the primary surgical treatment and primary delayed suture was done after 24 h. The macroscopic appearance and the clinical assessment of the wound were done during the primary surgical treatment and during its revision after 24 h, as well as histopathological findings at the days 4 and 7 after wounding. Results. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47 7.62 mm, and treated with fibrin glue with antibiotics after primary surgical management, were closed with primary delayed suture after 24 h. In further wound evolution there were no complications. Conclusion. Uncomplicated soft-tissue wounds caused by an automatic M70AB2 rifle may be closed primarily with delayed suture without the risk of developing complications if on revision, 24 h after primary surgery, there were no present necrotic tissues, hematoma, and any signs of infection when fibrin glue with antibiotics

  20. Preoperative embolization of nasopharyngeal angiofibromas: The role of direct percutaneous injection of cyanoacrylate glue in conjunction with particulate endovascular approach

    Directory of Open Access Journals (Sweden)

    Mohamed Abdel Hakim Osman Kasem

    2016-12-01

    Conclusion: The embolization of nasopharyngeal angiofibromas before surgery using percutaneous cyanoacrylate glue with endovascular particulate material proved to efficiently devascularize these tumours with lower blood loss during surgery and no major procedural complications.

  1. Distinguishing How from Why the Mind Wanders: A Process-Occurrence Framework for Self-Generated Mental Activity

    Science.gov (United States)

    Smallwood, Jonathan

    2013-01-01

    Cognition can unfold with little regard to the events taking place in the environment, and such self-generated mental activity poses a specific set of challenges for its scientific analysis in both cognitive science and neuroscience. One problem is that the spontaneous onset of self-generated mental activity makes it hard to distinguish the events…

  2. Development of Silicon Photomultipliers and their Applications to GlueX Calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Elton S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-07-01

    The GlueX experiment is a photoproduction experiment in Hall D at Jefferson Lab that is being commissioned for use with the new 12 GeV accelerator. The purpose of the experiment is to search for Hybrid mesons, which are mesons with quark and gluon degrees of freedom. The barrel calorimeter of GlueX is instrumented with 4000 large-area (1.2 x1.2 cm2) silicon photomultipliers (SiPMs). These photon sensors have properties similar to vacuum photomultipliers, but are unaffected by high magnetic fields. In our experiment they operate in magnetic fields exceeding 1T. After extensive tests with a variety of sensors, we chose the S12045(X) custom SiPM arrays manufactured by Hamamatsu Corporation, also known as multi-pixel photon counters (MPPCs). We will give an overview of this new technology as well as the experience gained during two commissioning periods with beam.

  3. Endoluminal embolization of bilateral atherosclerotic common iliac aneurysms with fibrin tissue glue (Beriplast)

    International Nuclear Information System (INIS)

    Beese, Richard C.; Tomlinson, Mark A.; Buckenham, Timothy M.

    2000-01-01

    The standard surgical approach to nonleaking iliac aneurysms found at repair of a leaking abdominal aortic aneurysm is to minimize the operative risk by repairing the abdominal aorta only. This means that the bypassed iliac aneurysms may have to be repaired later. As this population of patients are usually elderly with coexisting medical problems, interventional radiology is being used to embolize these aneurysms, thus avoiding the morbidity and mortality associated with further general anesthesia and surgery. Various materials and stents have been reported to be effective in the treatment of iliac aneurysms. We report the successful use of endoluminal fibrin tissue glue (Beriplast) to treat two large iliac aneurysms in a patient who had had a previous abdominal aortic aneurysm repair. We discuss the technique involved and the reasons why we used tissue glue in this patient.

  4. Endoscopic use of cyanoacrylate glue in the treatment of urethral fistula

    Directory of Open Access Journals (Sweden)

    Andre Ramos Sorgi Macedo

    2013-07-01

    Full Text Available Purpose The aim of this video is to demonstrate an endoscopic and minimally invasive repair of an urethrocutaneous fistula with cyanoacrylate glue. Materials and Methods: A 56 year-old-man with post-infectious urethral stricture and recurrent perineal abscess formation due to urethral fistulas. Results The operative time was 60 minutes, no major complications were observed perioperatively and postoperatively. At a follow-up time of 6 months the patient had no evidence of recurrent fistula and abscess formation. CONCLUSIONS The endoscopic use of cyanoacrylate glue represents a safe and minimally invasive approach that might be offered as a first line option for the treatment of urinary fistulas in selected patients, especially those with narrow and long tracts.

  5. Percutaneous sclerotherapy of sialoceles after parotidectomy with fibrin glue, OK-432, and bleomycin.

    Science.gov (United States)

    Chen, Wei-liang; Zhang, Li-ping; Huang, Zhi-quan; Zhou, Bin

    2013-12-01

    We evaluated the curative effect of fibrin glue combined with OK-432 (streptococcal pyrogenic exotoxin A, Picibanil™) and bleomycin on 9 patients with sialoceles after parotidectomy. The primary lesions included pleomorphic adenomas in 6 cases and Warthin's tumours in 3 cases. After a sialocele had been diagnosed each patient had repeated aspirations and pressure dressings for 3-4 weeks, but these treatments failed. The patients were then treated with percutaneous sclerotherapy with the injection of fibrin glue 8-10 ml combined with OK-432 5 mg and bleomycin 15 mg. All the sialoceles disappeared completely after a single procedure in 2-3 weeks. The patients have been followed up for more than 6 months with no evidence of recurrent sialocele or injury to the facial nerve related to sclerotherapy. This simple, safe technique can be successfully used to treat sialoceles after parotidectomy. Copyright © 2013 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  6. Development of silicon photomultipliers and their applications to GlueX calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Elton S., E-mail: elton@jlab.org [Jefferson Lab, Newport News, VA 23606 (United States)

    2016-07-07

    The GlueX experiment is a photoproduction experiment in Hall D at Jefferson Lab that is being commissioned for use with the new 12 GeV accelerator. The purpose of the experiment is to search for Hybrid mesons, which are mesons with quark and gluon degrees of freedom. The barrel calorimeter of GlueX is instrumented with 4000 large-area (1.2 × 1.2 cm{sup 2}) silicon photomultipliers (SiPMs). These photon sensors have properties similar to vacuum photomultipliers, but are unaffected by high magnetic fields. In our experiment they operate in magnetic fields exceeding 1T. After extensive tests with a variety of sensors, we chose the S12045(X) custom SiPM arrays manufactured by Hamamatsu Corporation, also known as multi-pixel photon counters (MPPCs). We will give an overview of this new technology as well as the experience gained during two commissioning periods with beam.

  7. Generalized likelihood uncertainty estimation (GLUE) using adaptive Markov chain Monte Carlo sampling

    DEFF Research Database (Denmark)

    Blasone, Roberta-Serena; Vrugt, Jasper A.; Madsen, Henrik

    2008-01-01

    propose an alternative strategy to determine the value of the cutoff threshold based on the appropriate coverage of the resulting uncertainty bounds. We demonstrate the superiority of this revised GLUE method with three different conceptual watershed models of increasing complexity, using both synthetic......In the last few decades hydrologists have made tremendous progress in using dynamic simulation models for the analysis and understanding of hydrologic systems. However, predictions with these models are often deterministic and as such they focus on the most probable forecast, without an explicit...... of applications. However, the MC based sampling strategy of the prior parameter space typically utilized in GLUE is not particularly efficient in finding behavioral simulations. This becomes especially problematic for high-dimensional parameter estimation problems, and in the case of complex simulation models...

  8. Role of cyanoacrylate glue therapy in enteral SEMS bleeding - A nightmare

    Directory of Open Access Journals (Sweden)

    Virukalpatti Goparathinam Mohanprasad

    2013-01-01

    Full Text Available Over the past century, the use of stents has evolved to a point where they are now used extensively throughout the gastrointestinal tract. Endoscopic stenting has become widely used for treatment of gastrointestinal and hepatobiliary strictures. Metallic stents are deployed in malignant strictures as a palliative procedure. Adverse events of stenting include perforation, migration, bleeding, occlusion, and pain. Finally, the use of multidisciplinary teams which include endoscopists, interventional radiologists, and surgeons allows for the exchange of ideas and procedural planning necessary for successful innovation. We present a case of successful cessation of bleeding by using cyanoacrylate glue therapy in post-enteral self-expandable metallic stent bleeding. In conclusion, glue therapy may also be considered as a mode of treatment other than conservative approach and angiographic coil embolization.

  9. Determining characteristic principal clusters in the “cluster-plus-glue-atom” model

    International Nuclear Information System (INIS)

    Du, Jinglian; Wen, Bin; 2NeT Lab, Wilfrid Laurier University, Waterloo, 75 University Ave West, Ontario N2L 3C5 (Canada))" data-affiliation=" (M2NeT Lab, Wilfrid Laurier University, Waterloo, 75 University Ave West, Ontario N2L 3C5 (Canada))" >Melnik, Roderick; Kawazoe, Yoshiyuki

    2014-01-01

    The “cluster-plus-glue-atom” model can easily describe the structure of complex metallic alloy phases. However, the biggest obstacle limiting the application of this model is that it is difficult to determine the characteristic principal cluster. In the case when interatomic force constants (IFCs) inside the cluster lead to stronger interaction than the interaction between the clusters, a new rule for determining the characteristic principal cluster in the “cluster-plus-glue-atom” model has been proposed on the basis of IFCs. To verify this new rule, the alloy phases in Cu–Zr and Al–Ni–Zr systems have been tested, and our results indicate that the present new rule for determining characteristic principal clusters is effective and reliable

  10. Fibrinogen and thrombin concentrations are critical for fibrin glue adherence in rat high-risk colon anastomoses

    Directory of Open Access Journals (Sweden)

    Eliseo Portilla-de Buen

    2014-04-01

    Full Text Available OBJECTIVE: Fibrin glues have not been consistently successful in preventing the dehiscence of high-risk colonic anastomoses. Fibrinogen and thrombin concentrations in glues determine their ability to function as sealants, healers, and/or adhesives. The objective of the current study was to compare the effects of different concentrations of fibrinogen and thrombin on bursting pressure, leaks, dehiscence, and morphology of high-risk ischemic colonic anastomoses using fibrin glue in rats. METHODS: Colonic anastomoses in adult female Sprague-Dawley rats (weight, 250-350 g treated with fibrin glue containing different concentrations of fibrinogen and thrombin were evaluated at post-operative day 5. The interventions were low-risk (normal or high-risk (ischemic end-to-end colonic anastomoses using polypropylene sutures and topical application of fibrinogen at high (120 mg/mL or low (40 mg/mL concentrations and thrombin at high (1000 IU/mL or low (500 IU/mL concentrations. RESULTS: Ischemia alone, anastomosis alone, or both together reduced the bursting pressure. Glues containing a low fibrinogen concentration improved this parameter in all cases. High thrombin in combination with low fibrinogen also improved adherence exclusively in low-risk anastomoses. No differences were detected with respect to macroscopic parameters, histopathology, or hydroxyproline content at 5 days post-anastomosis. CONCLUSIONS: Fibrin glue with a low fibrinogen content normalizes the bursting pressure of high-risk ischemic left-colon anastomoses in rats at day 5 after surgery.

  11. Optimization of performance parameters for large area silicon photomultipliers for use in the GlueX experiment

    Science.gov (United States)

    Janzen, Kathryn Louise

    Largely because of their resistance to magnetic fields, silicon photomultipliers (SiPMs) are being considered as the readout for the GlueX Barrel Calorimeter, a key component of the GlueX detector located immediately inside a 2.2 T superconducting solenoid. SiPMs with active area 1 x 1 mm2 have been investigated for use in other experiments, but detectors with larger active areas are required for the GlueX BCAL. This puts the GlueX collaboration in the unique position of being pioneers in the use of this frontend detection revolution by driving the technology for larger area sensors. SensL, a photonics research and development company in Ireland, has been collaborating with the University of Regina GlueX group to develop prototype large area SiPMs comprising 16 - 3x3 mm2 cells assembled in a close-packed matrix. Performance parameters of individual SensL 1x1 mm2 and 3x3 mm2 SiPMs along with prototype SensL SiPM arrays are tested, including current versus voltage characteristics, photon detection efficiency, and gain uniformity, in an effort to determine the suitability of these detectors to the GlueX BCAL readout.

  12. Dye-sensitized MIL-101 metal organic frameworks loaded with Ni/NiO{sub x} nanoparticles for efficient visible-light-driven hydrogen generation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xin-Ling; Wang, Rong; Yuan, Yu-Peng, E-mail: yupengyuan@ahu.edu.cn, E-mail: cxue@ntu.edu.sg [School of Chemistry and Chemical Engineering, and Innovation Lab for Clean Energy and Green Catalysis, Anhui University, Hefei 230036 (China); Zhang, Ming-Yi [Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin 150025 (China); Xue, Can, E-mail: yupengyuan@ahu.edu.cn, E-mail: cxue@ntu.edu.sg [Solar Fuels Lab, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore)

    2015-10-01

    The Ni/NiO{sub x} particles were in situ photodeposited on MIL-101 metal organic frameworks as catalysts for boosting H{sub 2} generation from Erythrosin B dye sensitization under visible-light irradiation. The highest H{sub 2} production rate of 125 μmol h{sup −1} was achieved from the system containing 5 wt. % Ni-loaded MIL-101 (20 mg) and 30 mg Erythrosin B dye. Moreover, the Ni/NiO{sub x} catalysts show excellent stability for long-term photocatalytic reaction. The enhancement on H{sub 2} generation is attributed to the efficient charge transfer from photoexcited dye to the Ni catalyst via MIL-101. Our results demonstrate that the economical Ni/NiO{sub x} particles are durable and active catalysts for photocatalytic H{sub 2} generation.

  13. Dye-sensitized MIL-101 metal organic frameworks loaded with Ni/NiOx nanoparticles for efficient visible-light-driven hydrogen generation

    Directory of Open Access Journals (Sweden)

    Xin-Ling Liu

    2015-10-01

    Full Text Available The Ni/NiOx particles were in situ photodeposited on MIL-101 metal organic frameworks as catalysts for boosting H2 generation from Erythrosin B dye sensitization under visible-light irradiation. The highest H2 production rate of 125 μmol h−1 was achieved from the system containing 5 wt. % Ni-loaded MIL-101 (20 mg and 30 mg Erythrosin B dye. Moreover, the Ni/NiOx catalysts show excellent stability for long-term photocatalytic reaction. The enhancement on H2 generation is attributed to the efficient charge transfer from photoexcited dye to the Ni catalyst via MIL-101. Our results demonstrate that the economical Ni/NiOx particles are durable and active catalysts for photocatalytic H2 generation.

  14. Evaluating mobile learning practice. Towards a framework for analysis of user-generated contexts with reference to the socio-cultural ecology of mobile learning

    Directory of Open Access Journals (Sweden)

    Judith Seipold

    2011-04-01

    Full Text Available Against the conceptual and theoretical background of a socio-culturally orientated approach to mobile learning (Pachler, Bachmair and Cook, 2010, this paper examines the evaluation of user-generated contexts by referring to an example from the use of mobile phones in schools. We discuss how mobile device-related, user- generated contexts around structures, agency and cultural practices might be brought into a fruitful relationship with institution-based learning. And, we provide categories for evaluating the use of mobile devices to generate meaning from and with fragmented and discontinuous media and modes at the interface of learning in formal, institutionalised and informal, self-directed settings. The evaluation criteria build on the framework of a socio-cultural ecology of mobile learning developed by the London Mobile Learning Group.

  15. Promoting Healthy Child Development via a Two-Generation Translational Neuroscience Framework: The Filming Interactions to Nurture Development Video Coaching Program.

    Science.gov (United States)

    Fisher, Philip A; Frenkel, Tahl I; Noll, Laura K; Berry, Melanie; Yockelson, Melissa

    2016-12-01

    In this article, we focus on applying methods of translational neuroscience to two-generation, family-based interventions. In recent years, a small but growing body of evidence has documented the reversibility of some of the neurobiological effects of early adversity in the context of environmental early interventions. Some of these interventions are now being implemented at scale, which may help reduce disparities in the face of early life stress. Further progress may occur by extending these efforts to two-generation models that target caregivers' capabilities to improve children's outcomes. In this article, we describe the content and processes of the Filming Interactions to Nurture Development (FIND) video coaching intervention. We also discuss the two-generation, translational neuroscience framework on which FIND is based, and how similar approaches can be developed and scaled to mitigate the effects of adversity.

  16. Effect of fibrin glue on the biomechanical properties of human Descemet's membrane.

    Directory of Open Access Journals (Sweden)

    Shyam S Chaurasia

    Full Text Available BACKGROUND: Corneal transplantation has rapidly evolved from full-thickness penetrating keratoplasty (PK to selective tissue corneal transplantation, where only the diseased portions of the patient's corneal tissue are replaced with healthy donor tissue. Descemet's membrane endothelial keratoplasty (DMEK performed in patients with corneal endothelial dysfunction is one such example where only a single layer of endothelial cells with its basement membrane (10-15 µm in thickness, Descemet's membrane (DM is replaced. It is challenging to replace this membrane due to its intrinsic property to roll in an aqueous environment. The main objective of this study was to determine the effects of fibrin glue (FG on the biomechanical properties of DM using atomic force microscopy (AFM and relates these properties to membrane folding propensity. METHODOLOGY/PRINCIPAL FINDINGS: Fibrin glue was sprayed using the EasySpray applicator system, and the biomechanical properties of human DM were determined by AFM. We studied the changes in the "rolling up" tendency of DM by examining the changes in the elasticity and flexural rigidity after the application of FG. Surface topography was assessed using scanning electron microscopy (SEM and AFM imaging. Treatment with FG not only stabilized and stiffened DM but also led to a significant increase in hysteresis of the glue-treated membrane. In addition, flexural or bending rigidity values also increased in FG-treated membranes. CONCLUSIONS/SIGNIFICANCE: Our results suggest that fibrin glue provides rigidity to the DM/endothelial cell complex that may aid in subsequent manipulation by maintaining tissue integrity.

  17. Effect of Fibrin Glue on the Biomechanical Properties of Human Descemet's Membrane

    Science.gov (United States)

    Chaurasia, Shyam S.; Champakalakshmi, Ravi; Li, Ang; Poh, Rebekah; Tan, Xiao Wei; Lakshminarayanan, Rajamani; Lim, Chwee T.; Tan, Donald T.; Mehta, Jodhbir S.

    2012-01-01

    Background Corneal transplantation has rapidly evolved from full-thickness penetrating keratoplasty (PK) to selective tissue corneal transplantation, where only the diseased portions of the patient's corneal tissue are replaced with healthy donor tissue. Descemet's membrane endothelial keratoplasty (DMEK) performed in patients with corneal endothelial dysfunction is one such example where only a single layer of endothelial cells with its basement membrane (10–15 µm in thickness), Descemet's membrane (DM) is replaced. It is challenging to replace this membrane due to its intrinsic property to roll in an aqueous environment. The main objective of this study was to determine the effects of fibrin glue (FG) on the biomechanical properties of DM using atomic force microscopy (AFM) and relates these properties to membrane folding propensity. Methodology/Principal Findings Fibrin glue was sprayed using the EasySpray applicator system, and the biomechanical properties of human DM were determined by AFM. We studied the changes in the “rolling up” tendency of DM by examining the changes in the elasticity and flexural rigidity after the application of FG. Surface topography was assessed using scanning electron microscopy (SEM) and AFM imaging. Treatment with FG not only stabilized and stiffened DM but also led to a significant increase in hysteresis of the glue-treated membrane. In addition, flexural or bending rigidity values also increased in FG-treated membranes. Conclusions/Significance Our results suggest that fibrin glue provides rigidity to the DM/endothelial cell complex that may aid in subsequent manipulation by maintaining tissue integrity. PMID:22662156

  18. Comparison of mechanical compressive properties of commercial and autologous fibrin glues for tissue engineering applications.

    Science.gov (United States)

    Cravens, Matthew G; Behn, Anthony W; Dragoo, Jason L

    2017-11-01

    Fibrin glues are widely used in orthopedic surgery as adhesives and hemostatic agents. We evaluated the compressive properties of selected fibrin glues in order to identify which are appropriate for tissue regeneration applications subject to compression. Uniaxial unconfined compression tests were performed on fibrin gels prepared from commercial and autologous products: (1) Evicel (Ethicon), (2) Tisseel (Baxter), (3) Angel (Arthrex), and (4) ProPlaz (Biorich). Cyclic loads were applied from 0 to 30% strain for 100cycles at 0.5Hz. Following cyclic testing, specimens were subjected to ramp displacement of 1% strain per second to 80% strain. Throughout cyclic loading, Evicel and Tisseel deformed (shortened) less than Angel at all but one time point, and deformed less than ProPlaz at cycles 10 and 20. The dynamic moduli, peak stress, and strain energy were significantly greater in Tisseel than all other groups. Evicel displayed significantly greater dynamic moduli, peak stress, and strain energy than Angel and ProPlaz. Following cyclic testing, Tisseel and Evicel were significantly less deformed than Angel. No specimens exhibited gross failure during ramp loading to 80% strain. Ramp loading trends mirrored those of cyclic loading. The tested commercial glues were significantly more resistant to compression than the autologous products. The compressive properties of Tisseel were approximately twice those of Evicel. All preparations displayed moduli multiple orders of magnitude less than that of native articular cartilage. We conclude that in knee surgeries requiring fibrin glue to undergo compression of daily activity, commercial products are preferable to autologous preparations from platelet-poor plasma, though both will deform significantly. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Glue-sniffing as a cause of a positive radio-isotope brain scan

    Energy Technology Data Exchange (ETDEWEB)

    Lamont, C M; Adams, F G

    1982-08-01

    Convulsions are a known complication of the acute intoxicant effects of solvent abuse. A radio-isotope brain scan done 9 months following status epilepticus secondary to toluene inhalation, in a previously normal school-boy, demonstrated several wedge-shaped areas of increased uptake, in both cerebral hemispheres, consistent with infarcts. It is worth remembering that a positive brain scan in a young person, with recent onset of epilepsy, may be due to glue-sniffing.

  20. Glue-sniffing as a cause of a positive radio-isotope brain scan

    International Nuclear Information System (INIS)

    Lamont, C.M.; Adams, F.G.

    1982-01-01

    Convulsions are a known complication of the acute intoxicant effects of solvent abuse. A radio-isotope brain scan done 9 months following status epilepticus secondary to toluene inhalation, in a previously normal school-boy, demonstrated several wedge-shaped areas if increased uptake, in both cerebral hemispheres, consistent with infarcts. It is worth remembering that a positive brain scan in a young person, with recent onset of epilepsy, may be due to glue-sniffing. (orig.)

  1. [The influence of biological compatibility of the cyanoacrylate glue on regeneration of the cartilaginous tissue].

    Science.gov (United States)

    Semenov, F V; Skibitskaya, N F

    The objective of the present study was to evaluate the possibility of the application of the cyanoacrylate-based glue for the strengthening of the reconstructed elements of the middle ear and its influence on the regeneration of the cartilaginous tissue. We used the cartilaginous tissue from the auricles of the male California rabbits as a model. The cartilage was destroyed in a standard press. Half of the cartilage thus fragmented was implanted into the left auricle. The remaining part was mixed up with the cyanoacrylate glue and implanted into the right auricle of the same animal. The implanted material was used for the morphological study on day 10, within 1 and 2 months after the beginning of the experiment. The results of the study confirm the absence of the toxic action of the biologically compatible cyanoacrylate-based glue on the regeneration of the cartilaginous and connective tissues which suggests the possibility of its application for the surgical treatment of the diseases of the middle ear.

  2. Intraoperative use of fibrin glue dyed with methylene blue in surgery for branchial cleft anomalies.

    Science.gov (United States)

    Piccioni, Michela; Bottazzoli, Marco; Nassif, Nader; Stefini, Stefania; Nicolai, Piero

    2016-09-01

    We present a new method of optimizing the results of surgery for branchial cleft anomalies based on the intraoperative injection of fibrin glue combined with methylene blue dye. Retrospective single-center cohort study. The method was applied in 17 patients suffering from branchial anomalies. Six (35.29%) had a preauricular lesion; three (17.65%) had lesions derived from the first arch/pouch/groove (type I), four (23.53%) had lesions derived from the first (type II), one (5.88%) had lesions derived from the second, one (5.88%) had lesions derived from the third, and two (11.76%) had lesions derived from the fourth. The median and mean age at surgery were 10 and 10.6 years, respectively. All patients were followed by periodic clinical and ultrasonographic examination. The combination of fibrin glue with methylene blue facilitated the correct assessment of the extension of the lesions and their intraoperative manipulation. After a mean follow-up of 47.8 months, all patients were free of disease. Intraoperative injection of branchial fistulae and cysts by a mixture of fibrin glue and methylene blue is an effective, easy, and safe tool to track lesions and achieve radical resection. The technique requires a definitive validation on a large cohort with adequate stratification of patients. 4 Laryngoscope, 126:2147-2150, 2016. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

  3. The impact and adoption of GLUE 2.0 in the LCG/EGEE production Grid

    International Nuclear Information System (INIS)

    Burke, Stephen; Andreozzi, Sergio; Donno, Flavia; Ehm, Felix; Field, Laurence; Litmaath, Maarten; Millar, Paul

    2010-01-01

    The GLUE information schema has been in use in the LCG/EGEE production Grid since the first version was defined in 2002. In 2007 a major redesign of GLUE, version 2.0, was started in the context of the Open Grid Forum following the creation of the GLUE Working Group. This process has taken input from a number of Grid projects, but as a major user of the version 1 schema LCG/EGEE has had a strong interest that the new schema should support its needs. In this paper we discuss the structure of the new schema in the light of the LCG/EGEE requirements and explain how they are met, and where improvements have been achieved compared with the version 1 schema. In particular we consider some difficulties encountered in recent extensions of the use of the version 1 schema to aid resource accounting in LCG, to enable the use of the SRM version 2 storage protocol by the LHC experiments, and to publish information about a wider range of services to improve service discovery. We describe how these can be better met by the new schema, and we also discuss the way in which the transition to the new schema is being managed.

  4. Use of fibrin glue in the management of recurrent pterygium by conjunctival autograft

    International Nuclear Information System (INIS)

    Virendra K. Malik; Sandeep Kumar

    2010-01-01

    To evaluate whether use of fibrin glue instead of sutures for the treatment of recurrent pterygium with conjunctival auto-graft (CAG) further decreases its recurrence. A prospective, clinical open trial of 50 eyes of 50 patients with recurrent pterygium, who were randomly assigned to either, pterygium excision and CAG with fibrin glue (Group 1) or with 6 interrupted sutures (Group 2), was carried out from January 2009 to July 2010 at the outpatient department of Subharti Medical College, Meerut, North India. Both groups had 25 patients each. The groups were compared with regards to the surgical time taken, development of recurrence, postoperative symptoms (irritation, watering, and redness), and complications. Recurrence was seen in one (4%) eye in group I, and 3 (12%) eyes in group II after 9-13 months of follow up. The difference between the 2 groups was not statistically significant. The surgical time was significantly reduced, and postoperative inflammation and complications were less in group I. Postoperative symptoms were significantly more in group II patients. While conjunctival autograft with sutures for management of recurrent pterygium appears to be a safe and feasible modality, fibrin glue fixation of the autograft is a more viable option in terms of surgical ease, less time consuming, less postoperative complications, and less recurrence (Author).

  5. Effect of Wheat Straw Pretreatments and Glue Formulations on particle board properties

    International Nuclear Information System (INIS)

    Jabeen, S.; Naveed, S.; Yousaf, S.; Ramzan, N.

    2014-01-01

    In this paper, the effect of wheat straw (WS) pretreatments and glue formulations on mechanical (i.e. Compressive Strength (CS) and Impact Strength (IS)) and water resistance properties (i.e. Thickness Swelling (TS) and water absorption (WA)) of particle board have been investigated and the results have been compared with conventional wooden particleboard. Wheat straw was treated with steam available at 110 degree C and 20 psig, for the retention time of 5, 10 and 15 min. The solution of 10% HCl was also used for removing the lignin. Particleboard was prepared by bonding treated WS with four types of glue recipes of synthetic and natural binders like urea formaldehyde (UF), polyvinyl acetate (PVA), corn flour (CF) and wheat flour (WF). The particle board was formed at the hydraulic pressure and temperature of 2800 psig and 80 degree C respectively. It was observed that WS particleboard has low mechanical strength and high water resistance in comparison with conventional board. The particle board prepared with HCl cured wheat straw and glue having high urea formaldehyde and corn flour has higher CS and IS as well as low TS and WA. It may be concluded that wheat straw is a good substitute of wood for particle board while using HCl as a modifying chemical and strong binders like urea formaldehyde and corn flour. (author)

  6. EFFICACY OF THROMBIN FIBRIN GLUE AND SCLE ROSANT IN THE MANAGEMENT OF BLEEDI NG GASTRIC VARICES

    Directory of Open Access Journals (Sweden)

    Sanjay Gupta

    2015-01-01

    Full Text Available Gastric varices are noted in up to 20 % of patents with portal hypertension , and are more common in those with non - cirrhotic etiology 1 . They bleed at lower portal pressures , bleed more severely and are associated with higher rates of rebleed , encephalopathy and mortality 1,2,3 . Variceal obliteration using tissue adhesives such as N - butyl cyanoacrylate leading to plugging and thrombosis of the gastric varices is currently the first line management option for obliteration of the gastric varices 3 . Although various options have been proposed , gold standard for management of gastric variceal bleeds is yet to be defined. We theorized that injection of the gastric varices using thrombin based glue followed by injection of a sclerosant shall be effective in optimum sclerotherapy and eradication of gastric varices. MATERIAL AND METHODS : All patients presenting with gastric variceal bleed were offered sclerotherapy with Thrombin fibrin based glue and sclerosant (TFG/S . During the study period 18 patients were enrolled in the TGF/S group. 21 patients underwent variceal plugging with n - butyl cyanoacrylate (NBC . There was no significant difference in age/ sex , duration of bleed or time interval between onset of bleed and endotherapy. RESULTS: Patients undergoing endotherapy with TGF/S had less episodes of bleed , and greater eradication of varices. CONCLUSION: The results with thrombin / fibrin glue and sclerotherapy are highly encouraging. Well - designed trials need to be performed KEYWORDS:Gastric varices; Thrombin Sclerotherapy

  7. Use of tissue glue for punch grafting in vitiligo - A preliminary report

    Directory of Open Access Journals (Sweden)

    Ghorpade Ashok

    2004-05-01

    Full Text Available BACKGROUND: Minipunch grafting has been successfully used for the treatment of stable vitiligo since several years. Post-operative immobilization at certain sites such as lips, areola & infralabial folds and joints is not easy to achieve. Putting stay sutures on the lips and areolae is difficult. Grafting over the joints may require hospitalization to ensure proper immobilization, and may discourage some patients. AIM: To study the efficacy of a tissue glue for immobilization of donor grafts at the above sites during minipunch grafting. METHODS: Ten cases with stable vitiligo over the lips, areolae, below the lower lip, and over different joints had tissue glue applied to the edges between the donor grafts and the recipient wells, after the grafting. RESULTS: The grafts adhered firmly within a minute and there was no need for a cumbersome dressing. Over the lips, the patients could resume talking and drinking fluids immediately. CONCLUSION: The glue was very helpful for immobilizing the grafts at these difficult sites.

  8. Strenght of the glue line of edge glued panels of Pinus taeda made with different adhesives

    Directory of Open Access Journals (Sweden)

    Merielen de Carvalho Lopes

    2013-12-01

    Full Text Available The study compares the strength of the glue line of edge glued panels of Pinus taeda made with different industrial adhesives. Three types of adhesives (poly(vinyl acetate (PVAc, emulsion polymer isocyanate (EPI and polyurethane (PU glued in two side gluing orientation (radial and tangential and analyzed after the conditioning tests (dry and wet were analyzed. The 360 specimens were prepared for determining the shear strength of edge glued panels of Pinus taeda, and these were tested in a universal testing machine called EMIC. The shear strength of the glue line at dry condition was lower in the tangential side for the three types of adhesives analyzed. The PU adhesive showed the highest values of shear strength in the applied conditions, differing from PVAc and EPI adhesive when tested on dry condition and did not differ from the others adhesives when tested on wet condition. The highest percentage of wood failure was observed after the shear strength test at dry condition to EPI adhesive glued in the radial side. And in the wet condition, the EPI adhesive and PU adhesive glued in tangential side showed higher mean values of wood failure. Thus, it was possible to conclude that the strength of the glue line of Pinus taeda wood was influenced by the type of adhesive and side gluing orientation, and showed differently behavior according to the condition of use (wet or dry.

  9. Percutaneous Glue Embolization of a Visceral Artery Pseudoaneurysm in a Case of Sickle Cell Anemia

    International Nuclear Information System (INIS)

    Gulati, Gurpreet S.; Gulati, Manpreet S.; Makharia, Govind; Hatimota, Pradeep; Saikia, Nripen; Paul, Shashi B.; Acharya, Subrat

    2006-01-01

    Although aneurysmal complications of sickle cell anemia have been described in the intracranial circulation, visceral artery pseudoaneurysms in this disease entity have not previously been reported in the literature. Conventional treatment of visceral pseudoaneurysms has been surgical ligation or resection of the aneurysm. Transcatheter embolization has emerged as an attractive, minimally invasive alternative to surgery in the treatment of these lesions. In certain situations, however, due to the unfavorable angiographic anatomy precluding safe transcatheter embolization, direct percutaneous glue injection of the pseudoaneurysm sac may be considered to achieve successful occlusion of the sac. The procedure may be rendered safer by simultaneous balloon protection of the parent artery. We describe this novel treatment modality in a case of inferior pancreaticoduodenal artery pseudoaneurysm in a patient with sickle cell anemia. Although a complication in the form of glue reflux into the parent vessel occurred that necessitated surgery, this treatment modality may be used in very selected cases (where conventional endovascular embolization techniques are not applicable) after careful selection of the balloon diameter and appropriate concentration of the glue-lipiodol mixture

  10. An icy-glue model of cometary nuclei

    International Nuclear Information System (INIS)

    Gombosi, T.I.; Houpis, H.L.F.

    1986-05-01

    Since 1950 a number of models have been proposed to explain the observations of comets. For the most part the icy conglomerate model of Whipple was the standard. Based on the recent images made by VEGA and GIOTTO spacecrafts of comet Halley, a model of the nucleus is suggested that retains the advantages of the icy conglomerate formalism on a local level, while a new global framework is introduced. The model is disscussed in terms of the mounting knowledge of comets, the creation of the nucleus in the cosmogenic sence, and expectations of future analysis of data and observations are presented. A new methodology for calculating the evolution and thermal profiles of the nucleus is also presented. (author)

  11. Utilizing the National Research Council's (NRC) Conceptual Framework for the Next Generation Science Standards (NGSS): A Self-Study in My Science, Engineering, and Mathematics Classroom

    Science.gov (United States)

    Corvo, Arthur Francis

    Given the reality that active and competitive participation in the 21 st century requires American students to deepen their scientific and mathematical knowledge base, the National Research Council (NRC) proposed a new conceptual framework for K--12 science education. The framework consists of an integration of what the NRC report refers to as the three dimensions: scientific and engineering practices, crosscutting concepts, and core ideas in four disciplinary areas (physical, life and earth/spaces sciences, and engineering/technology). The Next Generation Science Standards (NGSS ), which are derived from this new framework, were released in April 2013 and have implications on teacher learning and development in Science, Technology, Engineering, and Mathematics (STEM). Given the NGSS's recent introduction, there is little research on how teachers can prepare for its release. To meet this research need, I implemented a self-study aimed at examining my teaching practices and classroom outcomes through the lens of the NRC's conceptual framework and the NGSS. The self-study employed design-based research (DBR) methods to investigate what happened in my secondary classroom when I designed, enacted, and reflected on units of study for my science, engineering, and mathematics classes. I utilized various best practices including Learning for Use (LfU) and Understanding by Design (UbD) models for instructional design, talk moves as a tool for promoting discourse, and modeling instruction for these designed units of study. The DBR strategy was chosen to promote reflective cycles, which are consistent with and in support of the self-study framework. A multiple case, mixed-methods approach was used for data collection and analysis. The findings in the study are reported by study phase in terms of unit planning, unit enactment, and unit reflection. The findings have implications for science teaching, teacher professional development, and teacher education.

  12. [Propolis. The bee glue as presented by the Graeco-Roman literature].

    Science.gov (United States)

    Golder, Werner

    2004-01-01

    The bee glue, commonly known as propolis, has been employed for medical purposes already in teh ancient world. More than 15 Greek and Roman authors report on the preparation and application of the so-called third natural product of the bees (besides honey and wax). Aristoteles described the fundamental issues of its biology in his 'Historia Animalium' correctly. The bulk of propolis is obtained from the barks of poplars. Once carried in the hives, the glue is used to stabilize the cells and honeycombs and to protect the bees against invaders and cold weather. Propolis has been chiefly employed for the preparation of ointment and plasters. For this purpose, the viscous raw material was purified, moulded and boiled. In most preparations, the bee glue was only one of many (up to 20) pharmacologically active constituents and came to five to 20% of the mixture. Only rarely, a single drug therapy was using propolis was carried out. The application of the glue was most successful in general surgery and casualties. In that respect, the ancient physicians took advantage of the anti-edematous and anti-infectious properties of the substance. Thus, it was used to treat bumps, indurations, and slow-healing wounds. Moreover, cataplasms against swollen cervical nodes and indurations of the female breast often contained propolis. Finally, bee glue proved successful for the treatment of chronic backache and pain in the hip as well as fresh injuries of muscles and tendons. In the sector of skin diseases, lichens and condylomata were found to respond well to propolis. ALl this indications have been a matter of several records. However, the successful use of propolis in diseases of the stomach and liver has ben reported solely by Alexander of Tralles (6th century AD). Not counting the internal diseases, the spectrum of indications for propolis has not substantially changed as compared to the classical antiquity. Interestingly, radiation therapists have adopted the ancient remedy and

  13. Mobile-cloud assisted video summarization framework for efficient management of remote sensing data generated by wireless capsule sensors.

    Science.gov (United States)

    Mehmood, Irfan; Sajjad, Muhammad; Baik, Sung Wook

    2014-09-15

    Wireless capsule endoscopy (WCE) has great advantages over traditional endoscopy because it is portable and easy to use, especially in remote monitoring health-services. However, during the WCE process, the large amount of captured video data demands a significant deal of computation to analyze and retrieve informative video frames. In order to facilitate efficient WCE data collection and browsing task, we present a resource- and bandwidth-aware WCE video summarization framework that extracts the representative keyframes of the WCE video contents by removing redundant and non-informative frames. For redundancy elimination, we use Jeffrey-divergence between color histograms and inter-frame Boolean series-based correlation of color channels. To remove non-informative frames, multi-fractal texture features are extracted to assist the classification using an ensemble-based classifier. Owing to the limited WCE resources, it is impossible for the WCE system to perform computationally intensive video summarization tasks. To resolve computational challenges, mobile-cloud architecture is incorporated, which provides resizable computing capacities by adaptively offloading video summarization tasks between the client and the cloud server. The qualitative and quantitative results are encouraging and show that the proposed framework saves information transmission cost and bandwidth, as well as the valuable time of data analysts in browsing remote sensing data.

  14. Mobile-Cloud Assisted Video Summarization Framework for Efficient Management of Remote Sensing Data Generated by Wireless Capsule Sensors

    Directory of Open Access Journals (Sweden)

    Irfan Mehmood

    2014-09-01

    Full Text Available Wireless capsule endoscopy (WCE has great advantages over traditional endoscopy because it is portable and easy to use, especially in remote monitoring health-services. However, during the WCE process, the large amount of captured video data demands a significant deal of computation to analyze and retrieve informative video frames. In order to facilitate efficient WCE data collection and browsing task, we present a resource- and bandwidth-aware WCE video summarization framework that extracts the representative keyframes of the WCE video contents by removing redundant and non-informative frames. For redundancy elimination, we use Jeffrey-divergence between color histograms and inter-frame Boolean series-based correlation of color channels. To remove non-informative frames, multi-fractal texture features are extracted to assist the classification using an ensemble-based classifier. Owing to the limited WCE resources, it is impossible for the WCE system to perform computationally intensive video summarization tasks. To resolve computational challenges, mobile-cloud architecture is incorporated, which provides resizable computing capacities by adaptively offloading video summarization tasks between the client and the cloud server. The qualitative and quantitative results are encouraging and show that the proposed framework saves information transmission cost and bandwidth, as well as the valuable time of data analysts in browsing remote sensing data.

  15. Mobile-Cloud Assisted Video Summarization Framework for Efficient Management of Remote Sensing Data Generated by Wireless Capsule Sensors

    Science.gov (United States)

    Mehmood, Irfan; Sajjad, Muhammad; Baik, Sung Wook

    2014-01-01

    Wireless capsule endoscopy (WCE) has great advantages over traditional endoscopy because it is portable and easy to use, especially in remote monitoring health-services. However, during the WCE process, the large amount of captured video data demands a significant deal of computation to analyze and retrieve informative video frames. In order to facilitate efficient WCE data collection and browsing task, we present a resource- and bandwidth-aware WCE video summarization framework that extracts the representative keyframes of the WCE video contents by removing redundant and non-informative frames. For redundancy elimination, we use Jeffrey-divergence between color histograms and inter-frame Boolean series-based correlation of color channels. To remove non-informative frames, multi-fractal texture features are extracted to assist the classification using an ensemble-based classifier. Owing to the limited WCE resources, it is impossible for the WCE system to perform computationally intensive video summarization tasks. To resolve computational challenges, mobile-cloud architecture is incorporated, which provides resizable computing capacities by adaptively offloading video summarization tasks between the client and the cloud server. The qualitative and quantitative results are encouraging and show that the proposed framework saves information transmission cost and bandwidth, as well as the valuable time of data analysts in browsing remote sensing data. PMID:25225874

  16. An eFTD-VP framework for efficiently generating patient-specific anatomically detailed facial soft tissue FE mesh for craniomaxillofacial surgery simulation.

    Science.gov (United States)

    Zhang, Xiaoyan; Kim, Daeseung; Shen, Shunyao; Yuan, Peng; Liu, Siting; Tang, Zhen; Zhang, Guangming; Zhou, Xiaobo; Gateno, Jaime; Liebschner, Michael A K; Xia, James J

    2018-04-01

    Accurate surgical planning and prediction of craniomaxillofacial surgery outcome requires simulation of soft tissue changes following osteotomy. This can only be achieved by using an anatomically detailed facial soft tissue model. The current state-of-the-art of model generation is not appropriate to clinical applications due to the time-intensive nature of manual segmentation and volumetric mesh generation. The conventional patient-specific finite element (FE) mesh generation methods are to deform a template FE mesh to match the shape of a patient based on registration. However, these methods commonly produce element distortion. Additionally, the mesh density for patients depends on that of the template model. It could not be adjusted to conduct mesh density sensitivity analysis. In this study, we propose a new framework of patient-specific facial soft tissue FE mesh generation. The goal of the developed method is to efficiently generate a high-quality patient-specific hexahedral FE mesh with adjustable mesh density while preserving the accuracy in anatomical structure correspondence. Our FE mesh is generated by eFace template deformation followed by volumetric parametrization. First, the patient-specific anatomically detailed facial soft tissue model (including skin, mucosa, and muscles) is generated by deforming an eFace template model. The adaptation of the eFace template model is achieved by using a hybrid landmark-based morphing and dense surface fitting approach followed by a thin-plate spline interpolation. Then, high-quality hexahedral mesh is constructed by using volumetric parameterization. The user can control the resolution of hexahedron mesh to best reflect clinicians' need. Our approach was validated using 30 patient models and 4 visible human datasets. The generated patient-specific FE mesh showed high surface matching accuracy, element quality, and internal structure matching accuracy. They can be directly and effectively used for clinical

  17. Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty.

    Science.gov (United States)

    Sun, Ping; Cheng, Xiang; Deng, Shichang; Hu, Qinggang; Sun, Yi; Zheng, Qichang

    2017-02-07

    Chronic pain following mesh-based inguinal hernia repair is frequently reported, and has a significant impact on quality of life. Whether mesh fixation with glue can reduce chronic pain without increasing the recurrence rate is still controversial. To determine whether tissue adhesives can reduce postoperative complications, especially chronic pain, with no increase in recurrence rate, compared with sutures for mesh fixation in Lichtenstein hernia repair. We searched the following electronic databases with no language restrictions: the Cochrane Central Register of Controlled Trials (CENTRAL; issue 4, 2016) in the Cochrane Library (searched 11 May 2016), MEDLINE Ovid (1986 to 11 May 2016), Embase Ovid (1986 to 11 May 2016), Science Citation Index (Web of Science) (1986 to 11 May 2016), CBM (Chinese Biomedical Database), CNKI (China National Knowledge Infrastructure), VIP (a full-text database in China), Wanfang databases. We also checked reference lists of identified papers (included studies and relevant reviews). We included all randomised and quasi-randomised controlled trials comparing glue versus sutures for mesh fixation in Lichtenstein hernia repair. Cluster-RCTs were also eligible. Two review authors extracted data and assessed the risk of bias independently. Dichotomous outcomes were expressed as odds ratio (OR) with 95% confidence intervals (CI). Continuous outcomes were expressed as mean differences (MD) with 95% CIs. Twelve trials with a total of 1932 participants were included in this review. The overall postoperative chronic pain in the glue group was reduced by 37% (OR 0.63, 95% CI 0.44 to 0.91; 10 studies, 1418 participants, low-quality evidence) compared with the suture group. However, the results changed when we conducted subgroup analysis with regard to the type of mesh. Subgroup analysis of included studies using lightweight mesh showed the reduction of chronic pain was less profound and insignificant (OR 0.77, 95% CI 0.50 to 1.17). Subgroup

  18. Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS Inner Detector

    Science.gov (United States)

    Poley, L.; Bloch, I.; Edwards, S.; Friedrich, C.; Gregor, I.-M.; Jones, T.; Lacker, H.; Pyatt, S.; Rehnisch, L.; Sperlich, D.; Wilson, J.

    2016-05-01

    The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive used initially between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). However, this glue has several disadvantages, which motivated the search for an alternative. This paper presents a study of six ultra-violet (UV) cure glues and a glue pad for possible use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, thermal conduction and shear strength. Samples were thermally cycled, radiation hardness and corrosion resistance were also determined. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives than silver loaded glue. Results from electrical tests of first prototype modules constructed using these glues are presented.

  19. Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS Inner Detector

    International Nuclear Information System (INIS)

    Poley, L.; Bloch, I.; Friedrich, C.; Gregor, I.-M.; Edwards, S.; Pyatt, S.; Wilson, J.; Jones, T.; Lacker, H.; Rehnisch, L.; Sperlich, D.

    2016-01-01

    The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive used initially between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). However, this glue has several disadvantages, which motivated the search for an alternative. This paper presents a study of six ultra-violet (UV) cure glues and a glue pad for possible use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, thermal conduction and shear strength. Samples were thermally cycled, radiation hardness and corrosion resistance were also determined. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives than silver loaded glue. Results from electrical tests of first prototype modules constructed using these glues are presented.

  20. A comparative study of tissue glue and vicryl suture for conjunctival and scleral closure in conventional 20-gauge vitrectomy.

    Science.gov (United States)

    Batman, C; Ozdamar, Y; Mutevelli, S; Sonmez, K; Zilelioglu, G; Karakaya, J

    2009-06-01

    To describe the use of tissue glue to close scleral and conjunctival wounds, and to compare the clinical outcomes using tissue glue and vicryl suture for closing these areas in conventional 20-gauge (G) vitrectomy. Thirty eyes of 30 patients were included in this study. The indications for vitreoretinal surgery were diabetic vitreous haemorrhage with severe vitreoretinal traction in 10 eyes, retinal detachment and proliferative vitreoretinopathy in 14 eyes, and vitreous opacity in 6 eyes. Tissue glue (Tisseel, Baxter AG Industries, Vienna, Austria) was used to attach scleral and conjunctival wounds in 15 eyes and vicryl sutures in 15 eyes. The patients were allotted into two subgroups as tissue glue group (TG) and vicryl suture group (VG). The sclerotomy sites were evaluated with ultrasound biomicroscopy (UBM) postoperatively in TG. Follow-up period was 2 months. The groups were statistically compared for ocular signs and symptoms by Mann-Whitney U-test. No scleral wound leakage and conjunctival reattachment were observed at the end of the surgical procedure and during the follow-up period. No adverse effects were seen in TG. Abnormal fibrous ingrowth was not detected at the sclerotomy sites by means of UBM in TG. Patient comfort was significantly higher in TG than VG (P<0.05). Tissue glue has no adverse effects on ocular tissue and can be used as a substitute for suture materials, and the use of tissue glue decreases patient symptoms during the postoperative period after 20-G vitrectomy. Tissue glue can enable to perform sutureless surgery in the conventional 20-G vitrectomy.

  1. A Framework for Effective Assessment of Model-based Projections of Biodiversity to Inform the Next Generation of Global Conservation Targets

    Science.gov (United States)

    Myers, B.; Beard, T. D.; Weiskopf, S. R.; Jackson, S. T.; Tittensor, D.; Harfoot, M.; Senay, G. B.; Casey, K.; Lenton, T. M.; Leidner, A. K.; Ruane, A. C.; Ferrier, S.; Serbin, S.; Matsuda, H.; Shiklomanov, A. N.; Rosa, I.

    2017-12-01

    Biodiversity and ecosystems services underpin political targets for the conservation of biodiversity; however, previous incarnations of these biodiversity-related targets have not relied on integrated model based projections of possible outcomes based on climate and land use change. Although a few global biodiversity models are available, most biodiversity models lie along a continuum of geography and components of biodiversity. Model-based projections of the future of global biodiversity are critical to support policymakers in the development of informed global conservation targets, but the scientific community lacks a clear strategy for integrating diverse data streams in developing, and evaluating the performance of, such biodiversity models. Therefore, in this paper, we propose a framework for ongoing testing and refinement of model-based projections of biodiversity trends and change, by linking a broad variety of biodiversity models with data streams generated by advances in remote sensing, coupled with new and emerging in-situ observation technologies to inform development of essential biodiversity variables, future global biodiversity targets, and indicators. Our two main objectives are to (1) develop a framework for model testing and refining projections of a broad range of biodiversity models, focusing on global models, through the integration of diverse data streams and (2) identify the realistic outputs that can be developed and determine coupled approaches using remote sensing and new and emerging in-situ observations (e.g., metagenomics) to better inform the next generation of global biodiversity targets.

  2. A generative inference framework for analysing patterns of cultural change in sparse population data with evidence for fashion trends in LBK culture.

    Science.gov (United States)

    Kandler, Anne; Shennan, Stephen

    2015-12-06

    Cultural change can be quantified by temporal changes in frequency of different cultural artefacts and it is a central question to identify what underlying cultural transmission processes could have caused the observed frequency changes. Observed changes, however, often describe the dynamics in samples of the population of artefacts, whereas transmission processes act on the whole population. Here we develop a modelling framework aimed at addressing this inference problem. To do so, we firstly generate population structures from which the observed sample could have been drawn randomly and then determine theoretical samples at a later time t2 produced under the assumption that changes in frequencies are caused by a specific transmission process. Thereby we also account for the potential effect of time-averaging processes in the generation of the observed sample. Subsequent statistical comparisons (e.g. using Bayesian inference) of the theoretical and observed samples at t2 can establish which processes could have produced the observed frequency data. In this way, we infer underlying transmission processes directly from available data without any equilibrium assumption. We apply this framework to a dataset describing pottery from settlements of some of the first farmers in Europe (the LBK culture) and conclude that the observed frequency dynamic of different types of decorated pottery is consistent with age-dependent selection, a preference for 'young' pottery types which is potentially indicative of fashion trends. © 2015 The Author(s).

  3. A multistage framework for reliability-based distribution expansion planning considering distributed generations by a self-adaptive global-based harmony search algorithm

    International Nuclear Information System (INIS)

    Shivaie, Mojtaba; Ameli, Mohammad T.; Sepasian, Mohammad S.; Weinsier, Philip D.; Vahidinasab, Vahid

    2015-01-01

    In this paper, the authors present a new multistage framework for reliability-based Distribution Expansion Planning (DEP) in which expansion options are a reinforcement and/or installation of substations, feeders, and Distributed Generations (DGs). The proposed framework takes into account not only costs associated with investment, maintenance, and operation, but also expected customer interruption cost in the optimization as four problem objectives. At the same time, operational restrictions, Kirchhoff's laws, radial structure limitation, voltage limits, and capital expenditure budget restriction are considered as problem constraints. The proposed model is a non-convex optimization problem having a non-linear, mixed-integer nature. Hence, a hybrid Self-adaptive Global-based Harmony Search Algorithm (SGHSA) and Optimal Power Flow (OPF) were used and followed by a fuzzy satisfying method in order to obtain the final optimal solution. The SGHSA is a recently developed optimization algorithm which imitates the music improvisation process. In this process, the harmonists improvise their instrument pitches, searching for the perfect state of harmony. The planning methodology was demonstrated on the 27-node, 13.8-kV test system in order to demonstrate the feasibility and capability of the proposed model. Simulation results illustrated the sufficiency and profitableness of the newly developed framework, when compared with other methods. - Highlights: • A new multistage framework is presented for reliability-based DEP problem. • In this paper, DGs are considered as an expansion option to increase the flexibility of the proposed model. • In this paper, effective factors of DEP problem are incorporated as a multi-objective model. • In this paper, three new algorithms HSA, IHSA and SGHSA are proposed. • Results obtained by the proposed SGHSA algorithm are better than others

  4. The inter-agency joint project decades: a framework for comparatively assessing electricity generation options and strategies

    International Nuclear Information System (INIS)

    Bertel, E.

    1995-01-01

    The environmental and health-related impacts of different energy systems are become some the important issues for the years to come. The fact that all fuel chains for the electricity generation system involve some health risks and lead to some environmental impacts and that many countries have the need to define their energy programmes for the coming decades, have arouse a growing interest in the application of improved data, tools and techniques for comparative assessment of different electricity systems, and more specially for theirs environmental and human health aspects. The need to design and implement sustainable strategies in the electricity sector has been stressed in many international fora. The essential goal of sustainable strategies is to provide the energy services required for supporting economic growth and improving quality of life, especially in developing countries, while minimizing the health and environmental impacts of human activities. The inter-agency joint project on data bases and methodologies for comparative assessment of different energy sources for electricity generation (DECADES) has been established with the objective of enhancing capabilities for incorporating health and environmental issues in the comparative assessment of different electricity generation chains and strategies in the process of planning and decision making for the electricity sector. This project is carried out jointly by a number of international organizations. In order to cover the main issues to be addressed for carrying out this comparative assessment the DECADES project focuses on: technology inventory, development of an integrated software package for electricity system analysis and expansion planning, compilation and review of methodologies, analytical models and computerized tools for comparative assessment, some case studies addressing specific national or regional issues. (author). 3 boxes

  5. Fibrin glue mixed with platelet-rich fibrin as a scaffold seeded with dental bud cells for tooth regeneration.

    Science.gov (United States)

    Yang, Kai-Chiang; Wang, Chun-Hao; Chang, Hao-Hueng; Chan, Wing P; Chi, Chau-Hwa; Kuo, Tzong-Fu

    2012-11-01

    Odontogenesis is a complex process with a series of epithelial-mesenchymal interactions and odontogenic molecular cascades. In tissue engineering of teeth from stem cells, platelet-rich fibrin (PRF), which is rich in growth factors and cytokines, may improve regeneration. Accordingly, PRF was added into fibrin glue to enrich the microenvironment with growth factors. Unerupted second molar tooth buds were harvested from miniature swine and cultured in vitro for 3 weeks to obtain dental bud cells (DBCs). Whole blood was collected for the preparation of PRF and fibrin glue before surgery. DBCs were suspended in fibrin glue and then enclosed with PRF, and the DBC-fibrin glue-PRF composite was autografted back into the original alveolar sockets. Radiographic and histological examinations were used to identify the regenerated tooth structure 36 weeks after implantation. Immunohistochemical staining was used to detect proteins specific to tooth regeneration. One pig developed a complete tooth with crown, root, pulp, enamel, dentin, odontoblast, cementum, blood vessels, and periodontal ligaments in indiscriminate shape. Another animal had an unerupted tooth that expressed cytokeratin 14, dentin matrix protein-1, vascular endothelial growth factor, and osteopontin. This study demonstrated, using autogenic cell transplantation in a porcine model, that DBCs seeded into fibrin glue-PRF could regenerate a complete tooth. Copyright © 2011 John Wiley & Sons, Ltd.

  6. Introduction of a potent single-donor fibrin glue for vascular anastomosis: An animal study

    Directory of Open Access Journals (Sweden)

    Mehdi Rasti Ardakani

    2012-01-01

    Full Text Available Background: Vascular anastomosis is considered as a difficult surgical procedure. Although different alternative methods have been tried to tackle these difficulties, none were found to be successful. Commercial fibrin glue has recently been used for vascular anastomosis. However, it did not gain popularity due to some limitations such as low tensile strength, rapid removal by the immune system, and risk of transmission of blood-borne viral infections. In this article, we presented a novel method for producing single-donor human fibrin glue and determined its success rate for vascular anastomosis in an animal model. Materials ans Methods : In this study, 3 mL of single-donor fibrin sealant was prepared from 150 mL of whole blood containing 50-70 mg/mL of fibrinogen. The study was performed on 10 dogs and 5 cats. After transection of the carotid artery, both ends were anastomosed by means of 3-4 sutures (Prolene 8-0. The suture line was then sealed with one layer of the new fibrin sealant. After 3-8 weeks, the site of anastomosis was evaluated angiographically and morphologically for healing and possible complications such as thrombosis or aneurysm. Results: In evaluations 3 weeks after the surgery, all arterial anastomoses were patent in dogs, but some degree of subintimal hyperplasia was noted. After 8 weeks, all anastomoses were patent and the degree of subintimal hyperplasia was decreased. In cats on the other hand, after 4 weeks, all anastomoses were patent and subintimal hyperplasia was absent. Conclusions: Single-donor fibrin glue was a quite reliable and practical alternative to minimize suturing and therefore operative time in our animal model. This sealant can easily be obtained from the patient′s whole blood. Its application in humans would require further studies.

  7. Application of fibrin glue with bandage contact lens in pterygium surgery

    Directory of Open Access Journals (Sweden)

    Wei Liu

    2014-05-01

    Full Text Available AIM: To explore the efficacy of fibrin glue with bandage contact lens for pain relief after pterygium surgery performed with limbal autograft transplantation.METHODS: A prospective clinical trial was carried out in 52 patients(72 eyesoperated for primary nasal pterygium. All patients were randomly divided into the fibrin glue with bandage contact lens group(experimental group, 28 cases, 38 eyesand suture group(control group, 24 cases, 34 eyes. Autologous limbal graft taken from the superotemporal limbus was used to cover the sclera after pterygium excision under local anesthesia with 20g/L lidocaine. In experimental group, the transplant was attached to the sclera with fibrin tissue adhesive and in control group with 10-0 Virgin silk sutures. Experimental group weared bandage contact lens after surgery while the control group did not. The degree of pain after surgery was evaluated at 1, 2, 3, 5 and 7d after surgery. Follow-up was 6mo, matching degree of graft and complication such as infection, relapse, implant healing badness and subconjunctival cyst were mainly observed and recorded.RESULTS: The pain index scores of the experimental group were significantly less than those of control group(all P=0.000. In observation period, all conjunctival autografts in both groups were successfully attached and were intact without falling off, dissolution or recurrence and there were no complications such as infection, relapse, implant healing badness and subconjunctival cyst.CONCLUSION: Fibrin glue with bandage contact lens could significantly release pain response afterpterygium excision surgery.

  8. In vitro study of a new biodegradable nanocomposite based on poly propylene fumarate as bone glue

    Energy Technology Data Exchange (ETDEWEB)

    Shahbazi, S.; Moztarzadeh, F. [Department of Medical Engineering, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Sadeghi, G. Mir Mohamad [Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Jafari, Y., E-mail: y.j.arisman@gmail.com [Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan (Iran, Islamic Republic of)

    2016-12-01

    A novel poly propylene fumarate (PPF)-based glue which is reinforced by nanobioactive glass (NBG) particles and promoted by hydroxyethyl methacrylate (HEMA) as crosslinker agent, was developed and investigated for bone-to-bone bonding applications. In-vitro bioactivity, biodegradability, biocompatibility, and bone adhesion were tested and the results have verified that it can be used as bone glue. In an in-vitro condition, the prepared nanocomposite (PPF/HEMA/NBG) showed improved adhesion to wet bone surfaces. The combined tension and shear resistance between two wet bone surfaces was measured, and its maximum value was 9 ± 59 MPa. To investigate the bioactivity and biodegradability of the nanocomposite, it has been immersed in simulated body fluid (SBF). After 14 days exposure to SBF, a hydroxyapatite (HA) layer formed on the surface of the composite confirms the bioactivity of this material. In the XRD pattern of the nanocomposite surface, the HA characteristic diffraction peak at θ = 26 and 31.8 were observed. Also, by monitoring the weight change after 8 weeks immersion in SBF, the mass loss was about 16.46 wt%. It has been confirmed that this nanocomposite is a biodegradable material. Also, bioactivity and biodegradability of nanocomposite have been proved by SEM images. It has been showed that by using NBG particles and HEMA precursor, mechanical properties increased significantly. The ultimate tensile strength (UTS) of nanocomposite which contains 20% NBG and the ratio of 70/30 wt% PPF/HEMA (PHB.732) was approximately 62 MPa, while the UTS in the pure PPF/HEMA was about 32 MPa. High cell viability in this nanocomposite (MTT assays, 85–95%) can be attributed to the NBG nature which contains calcium phosphate and is similar to physiological environment. Furthermore, it possesses biomineralization and biodegradation which significantly affected by impregnation of hydrophilic HEMA in the PPF-based polymeric matrix. The results indicated that the new

  9. TRANS-ARTERIAL EMBOLIZATION WITH N-BUTYL CYANOACRYLATE GLUE FOR RENAL BLEEDING: Case Report

    Directory of Open Access Journals (Sweden)

    Benny Young

    2014-08-01

    Full Text Available Background: The objectivity in management of renal bleeding is to preserve a significant renal parenchyma tissue and prevent associated morbidities like anemic shock or renal impairment from substantial nephron demise or obstructed uropathy. Trans-arterial embolization therapy by interventional radiology offers a high success rate with potential of reserving normal renal tissue. The selection material for renal arterial embolization largely depends on vasculature anatomy and end-point of procedure. N-butyl cyanoacrylate glue in our experience is applied in lesion supplied by small size of end-artery. 

  10. Elaboración de cola de pergamino = Preparation of parchment glue

    OpenAIRE

    Tacón Clavaín, Javier

    2013-01-01

    En las páginas siguientes se describe mediante imágenes el proceso llevado a cabo en el Departamento de Conservación y Restauración para la elaboración de cola de pergamino. Este adhesivo tradicional es muy adecuado para su uso en consolidaciones y adhesiones en el campo de la restauración documental por su pureza y por su pH neutro. [ABSTRACT]In the following pages the process carried out in the Department of Conservation and Restoration for making parchment glue is described. This tradit...

  11. Uncertainty and sensitivity assessments of an agricultural-hydrological model (RZWQM2) using the GLUE method

    Science.gov (United States)

    Sun, Mei; Zhang, Xiaolin; Huo, Zailin; Feng, Shaoyuan; Huang, Guanhua; Mao, Xiaomin

    2016-03-01

    Quantitatively ascertaining and analyzing the effects of model uncertainty on model reliability is a focal point for agricultural-hydrological models due to more uncertainties of inputs and processes. In this study, the generalized likelihood uncertainty estimation (GLUE) method with Latin hypercube sampling (LHS) was used to evaluate the uncertainty of the RZWQM-DSSAT (RZWQM2) model outputs responses and the sensitivity of 25 parameters related to soil properties, nutrient transport and crop genetics. To avoid the one-sided risk of model prediction caused by using a single calibration criterion, the combined likelihood (CL) function integrated information concerning water, nitrogen, and crop production was introduced in GLUE analysis for the predictions of the following four model output responses: the total amount of water content (T-SWC) and the nitrate nitrogen (T-NIT) within the 1-m soil profile, the seed yields of waxy maize (Y-Maize) and winter wheat (Y-Wheat). In the process of evaluating RZWQM2, measurements and meteorological data were obtained from a field experiment that involved a winter wheat and waxy maize crop rotation system conducted from 2003 to 2004 in southern Beijing. The calibration and validation results indicated that RZWQM2 model can be used to simulate the crop growth and water-nitrogen migration and transformation in wheat-maize crop rotation planting system. The results of uncertainty analysis using of GLUE method showed T-NIT was sensitive to parameters relative to nitrification coefficient, maize growth characteristics on seedling period, wheat vernalization period, and wheat photoperiod. Parameters on soil saturated hydraulic conductivity, nitrogen nitrification and denitrification, and urea hydrolysis played an important role in crop yield component. The prediction errors for RZWQM2 outputs with CL function were relatively lower and uniform compared with other likelihood functions composed of individual calibration criterion. This

  12. Lifetime Improvement of Organic Light Emitting Diodes using LiF Thin Film and UV Glue Encapsulation

    Science.gov (United States)

    Huang, Jian-Ji; Su, Yan-Kuin; Chang, Ming-Hua; Hsieh, Tsung-Eong; Huang, Bohr-Ran; Wang, Shun-Hsi; Chen, Wen-Ray; Tsai, Yu-Sheng; Hsieh, Huai-En; Liu, Mark O.; Juang, Fuh-Shyang

    2008-07-01

    This work demonstrates the use of lithium fluoride (LiF) as a passivation layer and a newly developed UV glue for encapsulation on the LiF passivation layer to enhance the stability of organic light-emitting devices (OLEDs). Devices with double protective layers showed a 25-fold increase in operational lifetime compared to those without any packaging layers. LiF has a low melting point and insulating characteristics and it can be adapted as both a protective layer and pre-encapsulation film. The newly developed UV glue has a fast curing time of only 6 s and can be directly spin-coated onto the surface of the LiF passivation layer. The LiF thin film plus spin-coated UV glue is a simple packaging method that reduces the fabrication costs of OLEDs.

  13. A dynamic model of soil salinity and drainage generation in irrigated agriculture: A framework for policy analysis

    Science.gov (United States)

    Dinar, Ariel; Aillery, Marcel P.; Moore, Michael R.

    1993-06-01

    This paper presents a dynamic model of irrigated agriculture that accounts for drainage generation and salinity accumulation. Critical model relationships involving crop production, soil salinity, and irrigation drainage are based on newly estimated functions derived from lysimeter field tests. The model allocates land and water inputs over time based on an intertemporal profit maximization objective function and soil salinity accumulation process. The model is applied to conditions in the San Joaquin Valley of California, where environmental degradation from irrigation drainage has become a policy issue. Findings indicate that in the absence of regulation, drainage volumes increase over time before reaching a steady state as increased quantities of water are allocated to leaching soil salts. The model is used to evaluate alternative drainage abatement scenarios involving drainage quotas and taxes, water supply quotas and taxes, and irrigation technology subsidies. In our example, direct drainage policies are more cost-effective in reducing drainage than policies operating indirectly through surface water use, although differences in cost efficiency are relatively small. In some cases, efforts to control drainage may result in increased soil salinity accumulation, with implications for long-term cropland productivity. While policy adjustments may alter the direction and duration of convergence to a steady state, findings suggest that a dynamic model specification may not be necessary due to rapid convergence to a comon steady state under selected scenarios.

  14. Radiological objectives and severe accident mitigation strategy for the generation II PWRs in France in the framework of PLE

    International Nuclear Information System (INIS)

    Cenerino, G.; Dubreuil, M.; Raimond, E.; Pichereau, F.

    2012-01-01

    In France, EDF is involved in the construction of a first generation III (Gen III) reactor (European Pressurized Reactor - EPR) on Flamanville site next to two PWRs. Plant Life Extension (PLE) of reactors will consequently lead to simultaneous operation of Gen III and Gen II reactors during a long period of time. As a consequence, EDF was requested by the French Nuclear Safety Authority to prepare a PWR life management program including, in addition to an ageing management of Systems, Structures and Components, a consequent reactor safety enhancement program. The objective was stated to EDF by the French Nuclear Safety Authority: 'the safety objectives of the Gen III reactors should be used as a reference for all studies undertaken in the frame of PLE'. One part of the EDF program deals with additional arrangements able to reduce more drastically the consequences of any accident. The relevance, according to IRSN, of the EDF radiological objectives for Design Basis Accidents, of the new EDF objectives for Severe Accidents (SA) and of the EDF potential modifications for SA mitigation are presented. (author)

  15. Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS inner detector

    International Nuclear Information System (INIS)

    Poley, Luise; Bloch, Ingo; Edwards, Sam

    2016-04-01

    The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). This glue has several disadvantages, which motivated the search for an alternative. This paper presents a study concerning the use of six ultra-violet (UV) cure glues and a glue pad for use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, the thermal conduction and shear strength, thermal cycling, radiation hardness, corrosion resistance and shear strength tests. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives. Results from electrical tests of first prototype modules constructed using these glues are presented.

  16. Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS inner detector

    Energy Technology Data Exchange (ETDEWEB)

    Poley, Luise [DESY, Zeuthen (Germany); Humboldt Univ. Berlin (Germany); Bloch, Ingo [DESY, Zeuthen (Germany); Edwards, Sam [Birmingham Univ. (United Kingdom); and others

    2016-04-15

    The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). This glue has several disadvantages, which motivated the search for an alternative. This paper presents a study concerning the use of six ultra-violet (UV) cure glues and a glue pad for use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, the thermal conduction and shear strength, thermal cycling, radiation hardness, corrosion resistance and shear strength tests. These investigations led to the exclusion of three UV cure glues as well as the glue pad. Three UV cure glues were found to be possible better alternatives. Results from electrical tests of first prototype modules constructed using these glues are presented.

  17. Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal® FS system, and polyglycolic acid sheets as wound coverings after oral surgery.

    Science.gov (United States)

    Kouketsu, Atsumu; Nogami, Shinnosuke; Yamada-Fujiwara, Minami; Nagai, Hirokazu; Yamauchi, Kensuke; Mori, Shiro; Miyashita, Hitoshi; Kawai, Tadashi; Matsui, Aritsune; Kataoka, Yoshihiro; Satomi, Norihisa; Ezoe, Yushi; Abe, Satoko; Takeda, Yuri; Tone, Takeshi; Hirayama, Bunnichi; Kurobane, Tsuyoshi; Tashiro, Kazuki; Yanagisawa, Yuta; Takahashi, Tetsu

    2017-09-01

    The CryoSeal ® FS System has been recently introduced as an automated device for the production of complete fibrin glue from autologous plasma, rather than from pool allogenic or cattle blood, to prevent viral infection and allergic reaction. We evaluated the effectiveness of complete autologous fibrin glue and polyglycolic acid (PGA) sheet wound coverings in mucosa defect oral surgery. Postoperative pain, scar contracture, ingestion, tongue dyskinesia, and postoperative bleeding were evaluated in 12 patients who underwent oral (including the tongue) mucosa excision, and received a PGA sheet and an autologous fibrin glue covering. They were compared with 12 patients who received a PGA sheet and commercial allogenic fibrin glue. All cases in the complete autologous fibrin glue group demonstrated good wound healing without complications such as local infection or incomplete cure. All evaluated clinical measures in this group were similar or superior to the commercial allogenic fibrin glue group. Coagulation and adhesion quality achieved with this method was comparable to that with a PGA sheet and commercial fibrin glue. Covering oral surgery wounds with complete autologous fibrin glue produced by an automated device was convenient, safe, and reduced the risk of viral infection and allergic reaction associated with conventional techniques. Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  18. Guidelines for comparative assessment of the environmental impacts of wastes from electricity generation systems. A framework for the assessment and comparison of environmental impacts

    International Nuclear Information System (INIS)

    1995-02-01

    The report describes the initial phase of a project intended to provide guidance to those concerned with environmental aspects of solid and hazardous waste management in electrical energy production systems. The focus is on describing a methodology for assessing and comparing the environmental impact arising from these wastes, and thereby to provide an input to overall electrical generation comparison projects, such as DECADES. The structure of the report is as follows: after considering a range of electrical energy production systems with an outline discussion of the waste streams produced in each case, the relevant treatment technologies and disposal options are reviewed. Then the elements of the framework for comparative assessment proposed in this report are described. The types of environmental impact, environmental protection criteria and indicators or end-points to measure the impact, the way in which such impacts can be quantitatively assessed and compared are discussed. 59 refs, figs and tabs

  19. Generating a National Land Cover Dataset for Mexico at 30m Spatial Resolution in the Framework of the NALCMS Project.

    Science.gov (United States)

    Llamas, R. M.; Colditz, R. R.; Ressl, R.; Jurado Cruz, D. A.; Argumedo, J.; Victoria, A.; Meneses, C.

    2017-12-01

    The North American Land Change Monitoring System (NALCMS) is a tri-national initiative for mapping land cover across Mexico, United States and Canada, integrating efforts of institutions from the three countries. At the continental scale the group released land cover and change maps derived from MODIS image mosaics at 250m spatial resolution for 2005 and 2010. Current efforts are based on 30m Landsat images for 2010 ± 1 year. Each country uses its own mapping approach and sources for ancillary data, while ensuring that maps are produced in a coherent fashion across the continent. This paper presents the methodology and final land cover map of Mexico for the year 2010 that was later integrated into a continental map. The principal input for Mexico was the Monitoring Activity Data for Mexico (MAD-MEX) land cover map (version 4.3), derived from all available mostly cloud-free images for the year 2010. A total of 35 classes were regrouped to 15 classes of the NALCMS legend present in Mexico. Next, various issues of the automatically generated MAD-MEX land cover mosaic were corrected, such as: filling areas of no data due no cloud-free observation or gaps in Landsat 7 ETM+ images, filling inland water bodies which were left unclassified due to masking issues, relabeling isolated unclassified of falsely classified pixels, structural mislabeling due to data gaps, reclassifying areas of adjacent scenes with significant class disagreements and correcting obvious misclassifications, mostly of water and urban areas. In a second step minor missing areas and rare class snow and ice were digitized and a road network was added. A product such as NALCMS land cover map at 30m for North America is an unprecedented effort and will be without doubt an important source of information for many users around the world who need coherent land cover data over a continental domain as an input for a wide variety of environmental studies. The product release to the general public is expected

  20. A general contact mechanical formulation of multilayered structures and its application to deconvolute thickness/mechanical properties of glue used in surface force apparatus.

    Science.gov (United States)

    Math, Souvik; Horn, Roger; Jayaram, Vikram; Biswas, Sanjay Kumar

    2007-04-15

    Currently data obtained from surface force apparatus experiments are convoluted with the mechanical response of glue of unknown thickness, used to bond mica sheets to the substrates. This paper describes a formulation to precisely deconvolute out the forces between the mica sheets by determining the thickness of glue, knowing the mechanical properties of the glue. The formulation consists of a general solution based on the noniterative Hankel transform of the Laplace equation. The generality is achieved by treating all the layers except the one in contact as an effective lumped system consisting of a set of springs in series, where each spring represents a layer. The solution is validated by nanoindentation of trilayer systems consisting of layers with widely diverse mechanical properties, some differing from each other by three orders of magnitude. SFA experiments are done with carefully metered slabs of glue. The proposed method is validated by comparing the actual glue thicknesses with those determined using the present analysis.

  1. Glue ear: how good is the information on the World Wide Web?

    Science.gov (United States)

    Ritchie, L; Tornari, C; Patel, P M; Lakhani, R

    2016-02-01

    This paper objectively evaluates current information available to the general public related to glue ear on the World Wide Web. The term 'glue ear' was typed into the 3 most frequently used internet search engines - Google, Bing and Yahoo - and the first 20 links were analysed. The first 400 words of each page were used to calculate the Flesch-Kincaid readability score. Each website was subsequently graded using the Discern instrument, which gauges quality and content of literature. The websites Webmd.boots.com, Bupa.co.uk and Patient.co.uk received the highest overall scores. These reflected top scores in either readability or Discern instrument assessment, but not both. Readability and Discern scores increased with the presence of a marketing or advertising incentive. The Patient.co.uk website had the highest Discern score and third highest readability score. There is huge variation in the quality of information available to patients on the internet. Some websites may be accessible to a wide range of reading ages but have poor quality content, and vice versa. Clinicians should be aware of indicators of quality, and use validated instruments to assess and recommend literature.

  2. N-butyl Cyanoacrylate Glue Embolization of Arterial Networks to Facilitate Hepatic Arterial Skeletonization before Radioembolization

    Energy Technology Data Exchange (ETDEWEB)

    Samuelson, Shaun D.; Louie, John D.; Sze, Daniel Y., E-mail: dansze@stanford.edu [Stanford University School of Medicine, Division of Interventional Radiology (United States)

    2013-06-15

    Purpose. Avoidance of nontarget microsphere deposition via hepatoenteric anastomoses is essential to the safety of yttrium-90 radioembolization (RE). The hepatic hilar arterial network may remain partially patent after coil embolization of major arteries, resulting in persistent risk. We retrospectively reviewed cases where n-butyl cyanoacrylate (n-BCA) glue embolization was used to facilitate endovascular hepatic arterial skeletonization before RE. Methods. A total of 543 RE procedures performed between June 2004 and March 2012 were reviewed, and 10 were identified where n-BCA was used to embolize hepatoenteric anastomoses. Arterial anatomy, prior coil embolization, and technical details were recorded. Outcomes were reviewed to identify subsequent complications of n-BCA embolization or nontarget RE. Results. The rate of complete technical success was 80 % and partial success 20 %, with one nontarget embolization complication resulting in a minor change in treatment plan. No evidence of gastrointestinal or biliary ischemia or infarction was identified, and no microsphere-related gastroduodenal ulcerations or other evidence of nontarget RE were seen. Median volume of n-BCA used was <0.1 ml. Conclusion. n-BCA glue embolization is useful to eliminate hepatoenteric networks that may result in nontarget RE, especially in those that persist after coil embolization of major vessels such as the gastroduodenal and right gastric arteries.

  3. Management of nontraumatic corneal perforation with tectonic drape patch and cyanoacrylate glue.

    Science.gov (United States)

    Khalifa, Yousuf M; Bailony, M Rami; Bloomer, Michele M; Killingsworth, Daniel; Jeng, Bennie H

    2010-10-01

    To report a case of nontraumatic corneal perforation managed with a tectonic drape patch. Interventional case report. A 60-year-old patient with a corneal scar in his left eye likely secondary to herpes simplex virus interstitial keratitis underwent laser peripheral iridotomy for narrow angles. He developed progressive thinning of the cornea overlying the scar that led to a descemetocele and then ultimately a 1.2- × 1.7-mm perforation. Intraoperatively, several attempts were made to seal the perforation with cyanoacrylate glue, but the wound continued to leak. Sterile plastic drape that was on the surgical field was fashioned into a 2-mm-diameter patch, and the peripheral edge of the tectonic drape patch was glued over the perforation, successfully sealing the cornea. One week later, the drape patch was intact without leak, and a penetrating keratoplasty was carried out without complication. Tectonic drape patch technique for nontraumatic corneal perforations in which there is tissue loss is a viable temporizing option when cyanoacrylate glue alone fails and when there is no corneal tissue or amniotic membrane available to close the wound.

  4. Inorganic Glue Enabling High Performance of Silicon Particles as Lithium Ion Battery Anode

    KAUST Repository

    Cui, Li-Feng

    2011-01-01

    Silicon, as an alloy-type anode material, has recently attracted lots of attention because of its highest known Li+ storage capacity (4200 mAh/g). But lithium insertion into and extraction from silicon are accompanied by a huge volume change, up to 300, which induces a strong strain on silicon and causes pulverization and rapid capacity fading due to the loss of the electrical contact between part of silicon and current collector. Silicon nanostructures such as nanowires and nanotubes can overcome the pulverization problem, however these nano-engineered silicon anodes usually involve very expensive processes and have difficulty being applied in commercial lithium ion batteries. In this study, we report a novel method using amorphous silicon as inorganic glue replacing conventional polymer binder. This inorganic glue method can solve the loss of contact issue in conventional silicon particle anode and enables successful cycling of various sizes of silicon particles, both nano-particles and micron particles. With a limited capacity of 800 mAh/g, relatively large silicon micron-particles can be stably cycled over 200 cycles. The very cheap production of these silicon particle anodes makes our method promising and competitive in lithium ion battery industry. © 2011 The Electrochemical Society.

  5. [Use of fibrin glue in the prevention of leakage in pancreatico-jejunal anastomoses].

    Science.gov (United States)

    Stojanović, M; Jeremic, M; Stojanović, P; Stojiljković, M; Gmijović, D; Stanojković, Z; Savić, V; Djordjević, V; Cvetković, Z; Kostov, M; Colović, R

    2002-01-01

    The aim of this study was to test the protective effects of fibrin sealing on the pancreatico-jejunostomy (PJA), the high-risk anastomosis following pancreas head resection. Experimental study was performed on the mongrel dogs, divided in two groups (20 animals each): Experimental group-with end to end "dunking" PJA, protected by temporary occlusion of the pancreatic duct with fibrin sealant/Tissucol/Immuno Ag/, while control group was without any protective procedure. The animals were followed 5 months in order to study: protective effects of such procedure on the PJA quantified with the percent of anastomotic leakage, effects of the exocrine secretion and effects the endocrine function Results: PJA leakage occurred in 13.33% in control group. No leakage was registered in experimental group. Biochemical, histological and electron microscopic study showed slight transitory elevation of amylase levels. Fibrin glue plug was dissolved and pancreatic juice output was reestablished 12th days postoperatively. Long term follow-up showed no damages of the endocrine and exocrine pancreas. Pancreatic duct occlusion with fibrin glue appeared to be an useful method in the prevention of pancreatico-jejunostomy leakage, without negative effects on the exocrine and endocrine pancreas.

  6. Beam asymmetry Σ for π0 and η photoproduction on the proton at GlueX

    Science.gov (United States)

    Zhang, Zhenyu; GlueX Collaboration

    2016-09-01

    Measurements of meson photoproduction at high energies began almost 50 years ago with bubble chamber experiments at SLAC, DESY, and Cambridge. These data have been successfully described through Regge theory in terms of t-channel quasi-particle exchange. High statistics measurements of pseudoscalar meson photoproduction at GlueX, using the 9 GeV linearly-polarized, tagged photon beam in Jefferson Lab's Hall D, will provide important new constraints on these Regge models. These measurements will test our understanding of the photoproduction mechanism at high energy, which is a necessary first step toward the broader meson spectroscopy program at GlueX. Through finite energy sum rules, these measurements can also impose new constraints on the extraction of nucleon resonances from low energy photoproduction data. In this talk, preliminary results for the linearly polarized photon beam asymmetry Σ for the exclusive reactions γp -> pπ0 and γp -> pη will be presented. These are the first measurements of the η beam asymmetry at these energies. Supported by Jefferson Science Associates, LLC under U.S. DOE Contract No. DE-AC05-06OR23177 and the China Scholarship Council No. 201506275156.

  7. Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats

    Science.gov (United States)

    Despoudi, Kalliopi; Mantzoros, Ioannis; Ioannidis, Orestis; Cheva, Aggeliki; Antoniou, Nikolaos; Konstantaras, Dimitrios; Symeonidis, Savvas; Pramateftakis, Manousos George; Kotidis, Efstathios; Angelopoulos, Stamatis; Tsalis, Konstantinos

    2017-01-01

    AIM To evaluate the effect of local surgical adhesive glue (albumin/glutaraldehyde-Bioglue) on the healing of colonic anastomoses in rats. METHODS Forty Albino-Wistar male rats were randomly divided into two groups, with two subgroups of ten animals each. In the control group, an end-to-end colonic anastomosis was performed after segmental resection. In the Bioglue group, the anastomosis was protected with extraluminar application of adhesive glue containing albumin and glutaraldehyde. Half of the rats were sacrificed on the fourth and the rest on the eighth postoperative day. Anastomoses were resected and macroscopically examined. Bursting pressures were calculated and histological features were graded. Other parameters of healing, such as hydroxyproline and collagenase concentrations, were evaluated. The experimental data were summarized and computed from the results of a one-way ANOVA. Fisher’s exact test was applied to compare percentages. RESULTS Bursting pressures, adhesion formation, inflammatory cell infiltration, and collagen deposition were significantly higher on the fourth postoperative day in the albumin/glutaraldehyde group than in the control group. Furthermore, albumin/glutaraldehyde significantly increased adhesion formation, inflammatory cell infiltration, neoangiogenesis, and collagen deposition on the eighth postoperative day. There was no difference in fibroblast activity or hydroxyproline and collagenase concentrations. CONCLUSION Albumin/glutaraldehyde, when applied on colonic anastomoses, promotes their healing in rats. Therefore, the application of protective local agents in colonic anastomoses leads to better outcomes. PMID:28883693

  8. Identification and quantification of glue-like off-odors in elastic therapeutic tapes.

    Science.gov (United States)

    Denk, Philipp; Buettner, Andrea

    2018-05-01

    Elastic therapeutic tapes are an important tool in the field of physical therapy and medicine. These tapes contain types of adhesive. However, sensory evaluations revealed the release of pronounced and irritating odors of the tapes. Negative odors were, amongst others, reported in elastic therapeutic tapes containing acrylic adhesives. In this study, the odor of four different tape samples was evaluated applying a descriptive analysis approach carried out by a trained sensory panel. Afterwards, the volatile compounds were recovered from the samples by solvent extraction and isolated by solvent-assisted flavor evaporation (SAFE). The obtained distillates were subsequently analyzed by gas chromatography-olfactometry (GC-O) and two-dimensional GC-O coupled with mass spectrometry (2D-GC-MS/O). To determine the most potent odorants in the distillates, odor extract dilution analyses (OEDA) were carried out. Thirty-one odorants were successfully identified using this approach, which were all described for the first time as odorants in tapes. Amongst the set of volatiles, unsaturated and saturated aldehydes were present, eliciting fatty, soapy, and citrus-like odor impressions, as well as a range of glue-like, moldy, and fruity smelling odor-active volatiles, such as 2-ethyl-1-hexanol, butyl benzoate, and 3-phenyltoluene. Based on their relative intensities, the concentrations of the glue-like smelling substances were determined: 2-ethyl-1-hexanol, present in all samples, was determined with concentrations ranging from 10 to 200 mg/kg in the investigated tapes.

  9. The GlueX Start Counter and Beam Asymmetry$\\Sigma$ in Single $\\pi^{0}$ Photoproduction

    Energy Technology Data Exchange (ETDEWEB)

    Pooser, Eric [Florida Intl Univ., Miami, FL (United States)

    2016-03-26

    The GlueX experiment aims to study meson photoproduction while utilizing the coherent bremsstrahlung technique to produce a 9 GeV linearly polarized photon beam incident on a liquid H2 target. A Start Counter detector was fabricated to properly identify the accelerator electron beam buckets and to provide accurate timing information. The Start Counter detector was designed to operate at photon intensities of up to 108 γ/s in the coherent peak and provides a timing resolution ~300 ps so as to provide successful identification of the electron beam buckets to within 99% accuracy. Furthermore, the Start Counter detector provides excellent solid angle coverage, ~ 90% of 4π hermeticity, and a high degree of segmentation for background rejection. It consists of a cylindrical array of 30 scintillators with pointed ends that bend towards the beam at the downstream end. Magnetic field insensitive silicon photomultiplier detectors were selected as the readout system. An initial measurement of the beam asymmetry Sigma in the exclusive reaction γ$\\vec{p}$→ π0p, where π0 → γ has been carried out utilizing the GlueX spectrometer during the Spring 2015 commissioning run. The tagged photon energies ranged from 2.5≤ Eγ ≤ 3.0 GeV in the coherent peak. These measurements were then compared to the world data set and show remarkable agreement with only two hours of physics production running.

  10. Clinical observation on fibrin glue technique in pterygium surgery performed with limbal autograft transplantation

    Directory of Open Access Journals (Sweden)

    Hui Liu

    2013-07-01

    Full Text Available AIM: To compare the efficiency and safety of fibrin glue to suture technique in pterygium surgery performed with limbal autograft.METHODS: A prospective randomized clinical trial was carried out in 60 eyes of 48 patients operated for primary nasal pterygium. Autologous limbal graft taken from the superotemporal limbus was used to cover the sclera after pterygium excision under local anesthesia with 2% lidocaine. In 22 cases(30 eyes, the transplant was attached to the sclera with a fibrin tissue adhesive(group 1and in 26 cases(30 eyeswith 10-0 Virgin silk sutures(group 2. Patients were followed up at least for 3 months. Time of operation, matching degree of graft and visual analogue scale(VASscore were mainly observed and recorded. RESULTS: Patient symptoms were significantly less and biomicroscopic findings were better in group 1. Pterygium recurrence was seen in 1 case of group 1, and 1 case of group 2. Average surgery time was shorter(PCONCLUSION: Using fibrin glue for graft fixation in pterygium surgery causes significantly less postoperative pain and shortens surgery time significantly.

  11. Efficacy, Reliability, and Safety of Completely Autologous Fibrin Glue in Neurosurgical Procedures: Single-Center Retrospective Large-Number Case Study.

    Science.gov (United States)

    Nakayama, Noriyuki; Yano, Hirohito; Egashira, Yusuke; Enomoto, Yukiko; Ohe, Naoyuki; Kanemura, Nobuhiro; Kitagawa, Junichi; Iwama, Toru

    2018-01-01

    Commercially available fibrin glue (Com-FG), which is used commonly worldwide, is produced with pooled human plasma from multiple donors. However, it has added bovine aprotinin, which involves the risk of infection, allogenic immunity, and allergic reactions. We evaluate the efficacy, reliability, and safety of completely autologous fibrin glue (CAFG). From August 2014 to February 2016, prospective data were collected and analyzed from 153 patients. CAFG was prepared with the CryoSeal System using autologous blood and was applied during neurosurgical procedures. Using CAFG-soaked oxidized regenerated cellulose and/or polyglycolic acid sheets, we performed a pinpoint hemostasis, transposed the offending vessels in a microvascular decompression, and covered the dural incision to prevent cerebrospinal fluid leakage. The CryoSeal System had generated up to a mean of 4.51 mL (range, 3.0-8.4 mL) of CAFG from 400 mL autologous blood. Com-FG products were not used in our procedures. Only 6 patients required an additional allogeneic blood transfusion. The hemostatic effective rate was 96.1% (147 of 153 patients). Only 1 patient who received transsphenoidal surgery for a pituitary adenoma presented with the complication of delayed postoperative cerebrospinal fluid leakage (0.65%). No patient developed allergic reactions or systemic complications associated with the use of CAFG. CAFG effectively provides hemostatic, adhesive, and safety performance. The timing and three-dimensional shape of CAFG-soaked oxidized regenerated cellulose and/or polyglycolic acid sheets solidification can be controlled with slow fibrin formation. The cost to prepare CAFG is similar compared with Com-FG products, and it can therefore be easily used at most institutions. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. DNA glue

    DEFF Research Database (Denmark)

    Filichev, Vyacheslav V; Astakhova, Irina V.; Malakhov, Andrei D.

    2008-01-01

    Significant alterations in thermal stability of parallel DNA triplexes and antiparallel duplexes were observed upon changing the attachment of ethynylpyrenes from para to ortho in the structure of phenylmethylglycerol inserted as a bulge into DNA (TINA). Insertions of two ortho-TINAs as a pseudo...

  13. Versatile fabrication of paper-based microfluidic devices with high chemical resistance using scholar glue and magnetic masks.

    Science.gov (United States)

    Cardoso, Thiago M G; de Souza, Fabrício R; Garcia, Paulo T; Rabelo, Denilson; Henry, Charles S; Coltro, Wendell K T

    2017-06-29

    Simple methods have been developed for fabricating microfluidic paper-based analytical devices (μPADs) but few of these devices can be used with organic solvents and/or aqueous solutions containing surfactants. This study describes a simple fabrication strategy for μPADs that uses readily available scholar glue to create the hydrophobic flow barriers that are resistant to surfactants and organic solvents. Microfluidic structures were defined by magnetic masks designed with either neodymium magnets or magnetic sheets to define the patter, and structures were created by spraying an aqueous solution of glue on the paper surface. The glue-coated paper was then exposed to UV/Vis light for cross-linking to maximize chemical resistance. Examples of microzone arrays and microfluidic devices are demonstrated. μPADs fabricated with scholar glue retained their barriers when used with surfactants, organic solvents, and strong/weak acids and bases unlike common wax-printed barriers. Paper microzones and microfluidic devices were successfully used for colorimetric assays of clinically relevant analytes commonly detected in urinalysis to demonstrate the low background of the barrier material and generally applicability to sensing. The proposed fabrication method is attractive for both its ability to be used with diverse chemistries and the low cost and simplicity of the materials and process. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Bulk physicochemical, interconnectivity, and mechanical properties of calcium phosphate cements-fibrin glue composites for bone substitute applications

    NARCIS (Netherlands)

    Lopez-Heredia, M.A.; Pattipeilohy, J.; Hsu, S.; Grykien, M.; Weijden, B. van der; Leeuwenburgh, S.C.G.; Salmon, P.; Wolke, J.G.C.; Jansen, J.A.

    2013-01-01

    Calcium phosphate cements (CPCs) and fibrin glue (FG) are used for surgical applications. Their combination is promising to create bone substitutes able to promote cell attachment and bone remodeling. This study proposes a novel approach to create CPC-FG composites by simultaneous CPC setting and FG

  15. CT-guided percutaneous injection of the fibrin glue by 'double needle' technique for the treatment of sacral cysts

    International Nuclear Information System (INIS)

    Wang Ganggang; Chen Long; Yang Chao; Ni Caifang

    2013-01-01

    Objective: To analyze the efficacy and safety of CT-guided percutaneous injection of the fibrin glue by 'double needle' technique to treat sacral cyst. Methods: Clinical data of 20 cases with 'double-needle' injection of fibrin glue technology to treat sacral cyst were retrospectively analyzed. All patients had varying degrees of sacral nerve root compression symptoms. The treatment for sacral cyst was carried out after clear diagnosis was made. On the basis of CT-guided percutaneous injection of fibrin glue, the improved CT-guided percutaneous injection of fibrin glue by 'double-needle' technique was used to treat these patients. The average dose of fibrin glue was (5.9 ± 2.4) ml. The clinical results of improvement as to pain and neurological function were evaluated after follow-up of an average of 17 months. The assessment criteria were as follows: excellent, complete resolution of signs and symptoms, with the patient returning to his or her regular employment and no recurrence of cysts during 1 year of follow-up, good, symptoms and signs in the legs and perineal region resolved but with persistent pain in the lumbosacral region, which did not interfere with the patient's regular work (the cysts did not recur for 6 months during follow-up), fair, no improvement in clinical symptoms, but a decrease in cyst size on the imaging study, poor, no improvement in clinical symptoms and no observed changes in cyst size in imaging studies or recurrence. Results: Most patients experienced some degree of pain relief and functional improvement after fibrin glue therapy, with most experiencing complete or marked resolution of clinical symptoms. Nine patients reported excellent recovery, 8 reported good recovery, 2 reported fair recovery, and 1 reported poor recovery. The overall percentage of positive outcomes (excellent and good recovery) was 85%. No serious postoperative complications were discovered. Conclusions: CT guided percutaneous injection of the fibrin glue by

  16. Preliminary report of a sutureless onlay technique for incisional hernia repair using fibrin glue alone for mesh fixation.

    Science.gov (United States)

    Stoikes, Nathaniel; Webb, David; Powell, Ben; Voeller, Guy

    2013-11-01

    The Rives repair for ventral/incisional (V/I) hernias involves sublay mesh placement requiring retrorectus dissection and transfascial stitches. Chevrel described a repair by onlaying mesh after a unique primary fascial closure. Although Chevrel fixated mesh to the anterior fascia with sutures, he used fibrin glue for fascial closure reinforcement. We describe an onlay technique with mesh fixated to the anterior fascia solely with fibrin glue without suture fixation. From January 2010 to January 2012, 50 patients underwent a V/I hernia onlay technique with fibrin glue mesh fixation. Records were reviewed for technical details, demographics, mesh characteristics, and postoperative outcomes. Primary fascial closure with interrupted permanent suture was done with or without myofascial advancement flaps. Onlay polypropylene mesh was placed providing 8 cm of overlap. Fibrin glue was applied over the prosthesis and subcutaneous drains were placed. Mean age was 62.4 years. Mean body mass index was 30.1 kg/m(2). Average mesh size was 14.5 cm × 19.1 cm. Mean operative time was 144.4 minutes (range, 38 to 316 minutes). Mean discharge was postoperative Day 2.9 (range, 0 to 15 days). Morbidity included eight seromas, one hematoma, and three wound infections. Seventeen patients required components separation. Mean follow-up was 19.5 months with no recurrences. This is the first series describing fibrin glue alone for mesh fixation for V/I hernia repair. It allows for immediate prosthesis fixation to the anterior fascia. Early results are promising. Potential advantages include less operative time, less technical difficulty, and less long-term pain. A prospective trial is needed to evaluate this approach.

  17. Experimental Status of Exotic Mesons and the GlueX Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Daniel Carman

    2006-10-22

    One of the unanswered and most fundamental questions in physics regards the nature of the confinement mechanism of quarks and gluons in QCD. Exotic hybrid mesons manifest gluonic degrees of freedom and their spectroscopy will provide the data necessary to test assumptions in lattice QCD and the specific phenomenology leading to confinement. Within the past two decades a number of experiments have put forth tantalizing evidence for the existence of exotic hybrid mesons in the mass range below 2 GeV. This talk represents an overview of the available data and what has been learned. In looking toward the future, the GlueX experiment at Jefferson Laboratory represents a new initiative that will perform detailed spectroscopy of the light-quark meson spectrum. This experiment and its capabilities will be reviewed.

  18. Comparison of a plasma-based composite biologic sealant with fibrin glue (Tisseel) for vascular anastomoses.

    Science.gov (United States)

    Doillon, Charles J; Dion, Yves-Marie

    2004-12-01

    Biologic sealants are needed in numerous, more and more demanding, procedures--especially with developments occurring in endovascular and laparoscopic vascular techniques. An initial pilot study in dogs showed that a 4-cm aortotomy closed with a polyester patch sutured in place by a 4-mm-spaced running suture consistently led to massive hemorrhage. We then designed a study using five dogs where two aortotomies were done to compare the effect of Tisseel to that of an autologous sealant prepared in our laboratory. Arterial pressures and heparinization were maintained throughout the surgical procedure. Both biologic sealants prevented hemorrhage from the arteriotomy at unclamping. Macroscopic and histologic assessments were performed. At killing, one week later, the autologous sealant exhibited less blood saturation of the collagen sponge compared with Tisseel. The use of autologous plasma combined with other adhesive components could be an efficient alternative to allogenic fibrin glue. Further studies are needed to confirm these observations.

  19. A New Potential Cause in the Development of Toxic Anterior Segment Syndrome: Fibrin Glue

    Directory of Open Access Journals (Sweden)

    Selçuk Sızmaz

    2014-08-01

    Full Text Available Objectives: To present a potential cause for toxic anterior segment syndrome (TASS. Materials and Methods: We report 4 cases of TASS that occurred following uneventful phacoemulsification and intraocular lens implantation. Results: The 4 cases were the first consecutive 2 cases of 2 different surgery days, 5 months apart. The most prominent sign of TASS was limbus-to-limbus corneal edema. Pain and/or intraocular pressure rise were also common. All surgical and presurgical procedures were checked after the first outbreak, whereas the second outbreak required further investigation. Fibrin glue remnants from preceding pterygium surgery with conjunctival autografting were found to be the potential cause. Despite intensive corticosteroid therapy, corneal edema did not resolve in 2 patients who underwent keratoplasty. Conclusion: TASS is a sight-threatening condition which requires thorough investigation for prevention of new cases. All steps must be carefully revised. (Turk J Ophthalmol 2014; 44: 280-3

  20. Fibrin glue as the cell-delivery vehicle for mesenchymal stromal cells in regenerative medicine.

    Science.gov (United States)

    Wu, Xiuwen; Ren, Jianan; Li, Jieshou

    2012-05-01

    The use of tissue-engineering techniques such as stem-cell therapy to renew injured tissues is a promising strategy in regenerative medicine. As a cell-delivery vehicle, fibrin glues (FG) facilitate cell attachment, growth and differentiation and, ultimately, tissue formation and organization by its three-dimensional structure. Numerous studies have provided evidence that stromal cells derived from bone marrow (bone marrow stromal cells; BMSC) and adipose tissue (adipose-derived stromal cells; ADSC) contain a population of adult multipotent mesenchymal stromal cells (MSC) and endothelial progenitor cells that can differentiate into several lineages. By combining MSC with FG, the implantation could take advantage of the mutual benefits. Researchers and physicians have pinned their hopes on stem cells for developing novel approaches in regenerative medicine. This review focuses on the therapeutic potential of MSC with FG in bone defect reconstruction, cartilage and tendon injury repair, ligament, heart and nerve regeneration, and, furthermore, wound healing.

  1. Zwitterionic Nanofibers of Super-Glue for Transparent and Biocompatible Multi-Purpose Coatings

    Science.gov (United States)

    Mele, Elisa; Heredia-Guerrero, José A.; Bayer, Ilker S.; Ciofani, Gianni; Genchi, Giada G.; Ceseracciu, Luca; Davis, Alexander; Papadopoulou, Evie L.; Barthel, Markus J.; Marini, Lara; Ruffilli, Roberta; Athanassiou, Athanassia

    2015-09-01

    Here we show that macrozwitterions of poly(ethyl 2-cyanoacrylate), commonly called Super Glue, can easily assemble into long and well defined fibers by electrospinning. The resulting fibrous networks are thermally treated on glass in order to create transparent coatings whose superficial morphology recalls the organization of the initial electrospun mats. These textured coatings are characterized by low liquid adhesion and anti-staining performance. Furthermore, the low friction coefficient and excellent scratch resistance make them attractive as solid lubricants. The inherent texture of the coatings positively affects their biocompatibility. In fact, they are able to promote the proliferation and differentiation of myoblast stem cells. Optically-transparent and biocompatible coatings that simultaneously possess characteristics of low water contact angle hysteresis, low friction and mechanical robustness can find application in a wide range of technological sectors, from the construction and automotive industries to electronic and biomedical devices.

  2. Glue Ear, Hearing Loss and IQ: An Association Moderated by the Child’s Home Environment

    Science.gov (United States)

    Hall, Amanda J.; Maw, Richard; Midgley, Elizabeth; Golding, Jean; Steer, Colin

    2014-01-01

    Background Glue ear or otitis media with effusion (OME) is common in children and may be associated with hearing loss (HL). For most children it has no long lasting effects on cognitive development but it is unclear whether there are subgroups at higher risk of sequelae. Objectives To examine the association between a score comprising the number of times a child had OME and HL (OME/HL score) in the first four/five years of life and IQ at age 4 and 8. To examine whether any association between OME/HL and IQ is moderated by socioeconomic, child or family factors. Methods Prospective, longitudinal cohort study: the Avon Longitudinal Study of Parents and Children (ALSPAC). 1155 children tested using tympanometry on up to nine occasions and hearing for speech (word recognition) on up to three occasions between age 8 months and 5 years. An OME/HL score was created and associations with IQ at ages 4 and 8 were examined. Potential moderators included a measure of the child’s cognitive stimulation at home (HOME score). Results For the whole sample at age 4 the group with the highest 10% OME/HL scores had performance IQ 5 points lower [95% CI −9, −1] and verbal IQ 6 points lower [95% CI −10, −3] than the unaffected group. By age 8 the evidence for group differences was weak. There were significant interactions between OME/HL and the HOME score: those with high OME/HL scores and low 18 month HOME scores had lower IQ at age 4 and 8 than those with high OME/HL scores and high HOME scores. Adjusted mean differences ranged from 5 to 8 IQ points at age 4 and 8. Conclusions The cognitive development of children from homes with lower levels of cognitive stimulation is susceptible to the effects of glue ear and hearing loss. PMID:24498289

  3. Tolerance of glue embolization under local anesthesia in varicoceles: A comparative study of two different cyanoacrylates

    Energy Technology Data Exchange (ETDEWEB)

    Vanlangenhove, Peter, E-mail: peter.vanlangenhove@uzgent.be [Department of Vascular and Interventional Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium); Everaert, Karel [Department of Urology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium); Van Maele, Georges [Department of Statistics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium); Defreyne, Luc [Department of Vascular and Interventional Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent (Belgium)

    2014-03-15

    Purpose: To find out whether in varicocele embolization the copolymer cyanoacrylate glue (NBCA-MS) has a better patient tolerance compared to the monomer n-butyl-2-cyanoacrylate (NBCA). Materials and methods: N = 112 insufficient spermatic veins (left sided N = 84, right sided N = 28) diagnosed in N = 83 adult males were prospectively randomized for blinded embolization with either NBCA N = 54 (Histoacryl) or with NBCA-MS N = 58 (Glubran2). Before, during and up to one week after embolization, patient discomfort was assessed by a standardized pain scale. Type, location and side of discomfort were noted. Statistical analysis was performed with the Mann–Whitney U-test, the McNemar test and the Fisher's exact test. Results: Embolization caused discomfort in N = 48/112 (43%) spermatic veins, comprising N = 26/54 (48%) in the NBCA group and N = 22/58 (38%) in the NBCA-MS group. During the week after embolization, the overall number of discomfort reports rose to N = 62/106 (59%), with an increase to N = 30/53 (57%) in the NBCA group and to N = 32/53 (60%) in the NBCA-MS group. The number of immediate grade 2 to 4 pain reactions was N = 22/112 (20%), and rose to N = 37/106 (35%) after one week. No difference in discomfort during embolization and at 1 week after treatment was noted. Characteristics, severity grading, and location of discomfort were similar in both NBCA groups, regardless the time point of observation. Conclusion: Discomfort after glue embolization of varicocele is a common side effect, which might evolve to pain. The assumed lower inflammatory reaction on NBCA-MS was not translated in an improved tolerance.

  4. Pain experience during internal spermatic vein embolization for varicocele: comparison of two cyanoacrylate glues

    Energy Technology Data Exchange (ETDEWEB)

    Heye, Sam; Maleux, Geert; Wilms, Guido [University Hospital Gasthuisberg, Department of Radiology, Leuven (Belgium)

    2006-01-01

    The purpose of this study was to evaluate possible pain sensation differences in patients after retrograde varicocele embolization either with n-butyl-(2)-cyanoacrylate (NBCA) or with n-butyl-(2)-cyanoacrylate + methacryloxysulfolane (NBCA-MS). Transcatheter varicocele embolization was performed in 64 consecutive patients (62 left, two bilateral). Embolization was done with NBCA (n=32) or NBCA-MS (n=32). Immediately after the procedure, patients were asked to evaluate pain during embolization using a visual analog scale (VAS). Statistical analysis was done with Student's t test. Mean pain score on VAS was 3.23 (range: 0-8) for NBCA and 3.28 (range 0-9) for NBCA-MS. This difference was not significant (P=0.932). Independently of the type of glue, no difference in pain sensation (P value 0.421) was found between patients younger than 18 (n=29) and patients older than 18 years of age (n=35) (younger than18, mean 3.52; older than 18, mean 3.05). No difference in mean pain experience level (P=0.323) was seen in 11 patients with vessel wall perforation (23.4%) during the procedure (3.89; range: 0-8.5) in comparison with those without perforation (mean pain sensation level: 3.13; range: 0-9). No difference in pain experience was found after transcatheter varicocele embolization either with NBCA or NBCA-MS. Age and vessel wall perforation have no influence on pain sensation independently of the type of glue. (orig.)

  5. Pain experience during internal spermatic vein embolization for varicocele: comparison of two cyanoacrylate glues

    International Nuclear Information System (INIS)

    Heye, Sam; Maleux, Geert; Wilms, Guido

    2006-01-01

    The purpose of this study was to evaluate possible pain sensation differences in patients after retrograde varicocele embolization either with n-butyl-(2)-cyanoacrylate (NBCA) or with n-butyl-(2)-cyanoacrylate + methacryloxysulfolane (NBCA-MS). Transcatheter varicocele embolization was performed in 64 consecutive patients (62 left, two bilateral). Embolization was done with NBCA (n=32) or NBCA-MS (n=32). Immediately after the procedure, patients were asked to evaluate pain during embolization using a visual analog scale (VAS). Statistical analysis was done with Student's t test. Mean pain score on VAS was 3.23 (range: 0-8) for NBCA and 3.28 (range 0-9) for NBCA-MS. This difference was not significant (P=0.932). Independently of the type of glue, no difference in pain sensation (P value 0.421) was found between patients younger than 18 (n=29) and patients older than 18 years of age (n=35) (younger than18, mean 3.52; older than 18, mean 3.05). No difference in mean pain experience level (P=0.323) was seen in 11 patients with vessel wall perforation (23.4%) during the procedure (3.89; range: 0-8.5) in comparison with those without perforation (mean pain sensation level: 3.13; range: 0-9). No difference in pain experience was found after transcatheter varicocele embolization either with NBCA or NBCA-MS. Age and vessel wall perforation have no influence on pain sensation independently of the type of glue. (orig.)

  6. Experimental study of fast electron transport and of the propagation of shock waves generated by laser in the framework of inertial fusion

    International Nuclear Information System (INIS)

    Sakaki, T.

    2016-01-01

    This document presents 3 experiments carried out within the framework of inertial fusion. The first experiment was devoted to the study of fast electron beam transport in a compressed target. The implosion of the target with a cylindrical geometry was carried out with the GEKKO XII laser facility (ILE Osaka, Japan). The fast electron beam was generated by the LFEX laser (∼10"1"9 W/cm"2) and its propagation through the compressed cylinder was observed with several X-ray diagnostics. This experiment showed the guiding effect of the electron beam resulting from self-generated magnetic fields. Furthermore, the results of this experiment were in good agreement with numerical simulations. Two other experiments were performed to study the propagation of strong shock waves created by lasers in a plasma. They were carried out with different laser systems. In the first experiment with the Gekko XII laser, we observed the creation and the propagation of two successive shock waves in an ablation plasma in CH and Be. The objective of characterizing the amplification of a transmitted shock by the collision of two counter-propagating shocks has been partially realized. The comparison of the experimental results with the hydrodynamic simulations enabled us to confirm an amplification of the shock by a factor 2 in pressure in the condition of this experiment. The shot with a Be target allowed the development and validation of the diagnostic method of X-ray radiography for shock wave propagation. The second experiment was performed with PHELIX GSI laser (Darmstadt, Germany). The purpose of this experiment was to study the generation of strong shocks. They were applied to study the equation of state of carbon in the WDM state. The condition of pressure and density for the carbon were obtained by deducing the pressure and the velocity of the shock wave chronometric diagnostics employed in this experiment. In this experiment, diamond was at the metallic liquid phase with a pressure

  7. SU-F-T-141: Proton Dose Validation in a Phantom Beyond TRUFILL N-BCA Embolization Glue

    International Nuclear Information System (INIS)

    Mandapaka, A; Ghebremedhin, A; Patyal, B; Linda, Loma

    2016-01-01

    Purpose: To validate the treatment planning system predicted proton dose beyond a heterogeneity (n-BCA glue) by making a measurement in a custom acrylic phantom. Methods: A custom cubic acrylic phantom was designed for this experiment. A container was designed to fit in the phantom. This container was filled with TRUFILL™ n-Butyl Cyanoacrylate(n-BCA) glue. When the container was placed in the phantom, its center was at a distance of 7.4cm from the entrance. This depth allows us to make measurements around the center of modulation of a 126 MeV proton beam with a 3cm spread-out-Bragg peak. To make measurements at other beam energies, additional acrylic can be added in front of the phantom, to adjust the depth of the heterogeneity. A diamond detector was cross calibrated against a standard cylindrical ion chamber in a 126MeV beam. The diamond detector was then used to make dose measurements beyond the inhomogeneity. The measurement was repeated with the container filled with water. Several measurements were made at each setup, to check reproducibility of measurements. Results: For the same number of Tic3R1 counts, the dose measured with the diamond detector beyond n-BCA glue was 1.053 times the dose measured beyond the water filled container. This result is in agreement with the measured stopping power of glue (1.06). These measurements were in agreement with the dose predicted by the treatment planning system when the electron density of the heterogeneity was replaced with 1.06 before the dose calculation. Conclusion: Our initial measurements validate the dose predicted by our treatment plan in the presence of heterogeneity in a phantom. The material tested (n-BCA glue) is commonly used in the treatment of AVM’s prior to an SRS treatment. An error in dose predicted by the treatment plan in the presence of the glue can be detrimental in a single fraction high dose SRS treatment I received the n-BCA liquid embolic system samples from Codman and Shurtleff, Inc.

  8. SU-F-T-141: Proton Dose Validation in a Phantom Beyond TRUFILL N-BCA Embolization Glue

    Energy Technology Data Exchange (ETDEWEB)

    Mandapaka, A; Ghebremedhin, A; Patyal, B; Linda, Loma [University Medical Center, Loma Linda, CA (United States)

    2016-06-15

    Purpose: To validate the treatment planning system predicted proton dose beyond a heterogeneity (n-BCA glue) by making a measurement in a custom acrylic phantom. Methods: A custom cubic acrylic phantom was designed for this experiment. A container was designed to fit in the phantom. This container was filled with TRUFILL™ n-Butyl Cyanoacrylate(n-BCA) glue. When the container was placed in the phantom, its center was at a distance of 7.4cm from the entrance. This depth allows us to make measurements around the center of modulation of a 126 MeV proton beam with a 3cm spread-out-Bragg peak. To make measurements at other beam energies, additional acrylic can be added in front of the phantom, to adjust the depth of the heterogeneity. A diamond detector was cross calibrated against a standard cylindrical ion chamber in a 126MeV beam. The diamond detector was then used to make dose measurements beyond the inhomogeneity. The measurement was repeated with the container filled with water. Several measurements were made at each setup, to check reproducibility of measurements. Results: For the same number of Tic3R1 counts, the dose measured with the diamond detector beyond n-BCA glue was 1.053 times the dose measured beyond the water filled container. This result is in agreement with the measured stopping power of glue (1.06). These measurements were in agreement with the dose predicted by the treatment planning system when the electron density of the heterogeneity was replaced with 1.06 before the dose calculation. Conclusion: Our initial measurements validate the dose predicted by our treatment plan in the presence of heterogeneity in a phantom. The material tested (n-BCA glue) is commonly used in the treatment of AVM’s prior to an SRS treatment. An error in dose predicted by the treatment plan in the presence of the glue can be detrimental in a single fraction high dose SRS treatment I received the n-BCA liquid embolic system samples from Codman and Shurtleff, Inc.

  9. Quantum-dot-sensitized solar cells fabricated by the combined process of the direct attachment of colloidal CdSe quantum dots having a ZnS glue layer and spray pyrolysis deposition.

    Science.gov (United States)

    Im, Sang Hyuk; Lee, Yong Hui; Seok, Sang Il; Kim, Sung Woo; Kim, Sang-Wook

    2010-12-07

    We were able to attach CdSe quantum dots (QDs) having a ZnS inorganic glue layer directly to a mesoporous TiO(2) (mp-TiO(2)) surface by spray coating and thermal annealing. Quantum-dot-sensitized solar cells based on CdSe QDs having ZnS as the inorganic glue layer could easily transport generated charge carriers because of the intimate bonding between CdSe and mp-TiO(2). The application of spray pyrolysis deposition (SPD) to obtain additional CdSe layers improved the performance characteristics to V(oc) = 0.45 V, J(sc) = 10.7 mA/cm(2), fill factor = 35.8%, and power conversion efficiency = 1.7%. Furthermore, ZnS post-treatment improved the device performance to V(oc) = 0.57 V, J(sc) = 11.2 mA/cm(2), fill factor = 35.4%, and power conversion efficiency = 2.2%.

  10. A second generation framework for the analysis of microsatellites in expressed sequence tags and the development of EST-SSR markers for a conifer, Cryptomeria japonica

    Directory of Open Access Journals (Sweden)

    Ueno Saneyoshi

    2012-04-01

    Full Text Available Abstract Background Microsatellites or simple sequence repeats (SSRs in expressed sequence tags (ESTs are useful resources for genome analysis because of their abundance, functionality and polymorphism. The advent of commercial second generation sequencing machines has lead to new strategies for developing EST-SSR markers, necessitating the development of bioinformatic framework that can keep pace with the increasing quality and quantity of sequence data produced. We describe an open scheme for analyzing ESTs and developing EST-SSR markers from reads collected by Sanger sequencing and pyrosequencing of sugi (Cryptomeria japonica. Results We collected 141,097 sequence reads by Sanger sequencing and 1,333,444 by pyrosequencing. After trimming contaminant and low quality sequences, 118,319 Sanger and 1,201,150 pyrosequencing reads were passed to the MIRA assembler, generating 81,284 contigs that were analysed for SSRs. 4,059 SSRs were found in 3,694 (4.54% contigs, giving an SSR frequency lower than that in seven other plant species with gene indices (5.4–21.9%. The average GC content of the SSR-containing contigs was 41.55%, compared to 40.23% for all contigs. Tri-SSRs were the most common SSRs; the most common motif was AT, which was found in 655 (46.3% di-SSRs, followed by the AAG motif, found in 342 (25.9% tri-SSRs. Most (72.8% tri-SSRs were in coding regions, but 55.6% of the di-SSRs were in non-coding regions; the AT motif was most abundant in 3′ untranslated regions. Gene ontology (GO annotations showed that six GO terms were significantly overrepresented within SSR-containing contigs. Forty–four EST-SSR markers were developed from 192 primer pairs using two pipelines: read2Marker and the newly-developed CMiB, which combines several open tools. Markers resulting from both pipelines showed no differences in PCR success rate and polymorphisms, but PCR success and polymorphism were significantly affected by the expected PCR product size

  11. A second generation framework for the analysis of microsatellites in expressed sequence tags and the development of EST-SSR markers for a conifer, Cryptomeria japonica

    Science.gov (United States)

    2012-01-01

    Background Microsatellites or simple sequence repeats (SSRs) in expressed sequence tags (ESTs) are useful resources for genome analysis because of their abundance, functionality and polymorphism. The advent of commercial second generation sequencing machines has lead to new strategies for developing EST-SSR markers, necessitating the development of bioinformatic framework that can keep pace with the increasing quality and quantity of sequence data produced. We describe an open scheme for analyzing ESTs and developing EST-SSR markers from reads collected by Sanger sequencing and pyrosequencing of sugi (Cryptomeria japonica). Results We collected 141,097 sequence reads by Sanger sequencing and 1,333,444 by pyrosequencing. After trimming contaminant and low quality sequences, 118,319 Sanger and 1,201,150 pyrosequencing reads were passed to the MIRA assembler, generating 81,284 contigs that were analysed for SSRs. 4,059 SSRs were found in 3,694 (4.54%) contigs, giving an SSR frequency lower than that in seven other plant species with gene indices (5.4–21.9%). The average GC content of the SSR-containing contigs was 41.55%, compared to 40.23% for all contigs. Tri-SSRs were the most common SSRs; the most common motif was AT, which was found in 655 (46.3%) di-SSRs, followed by the AAG motif, found in 342 (25.9%) tri-SSRs. Most (72.8%) tri-SSRs were in coding regions, but 55.6% of the di-SSRs were in non-coding regions; the AT motif was most abundant in 3′ untranslated regions. Gene ontology (GO) annotations showed that six GO terms were significantly overrepresented within SSR-containing contigs. Forty–four EST-SSR markers were developed from 192 primer pairs using two pipelines: read2Marker and the newly-developed CMiB, which combines several open tools. Markers resulting from both pipelines showed no differences in PCR success rate and polymorphisms, but PCR success and polymorphism were significantly affected by the expected PCR product size and number of SSR

  12. Migration to the GLUE 2.0 information schema in the LCG/EGEE/EGI production Grid

    International Nuclear Information System (INIS)

    Burke, Stephen; Field, Laurence; Horat, David

    2011-01-01

    The GLUE information schema has been in use in the LCG/EGEE production Grid since the first version was released in 2002. In 2008 a major redesign of GLUE, version 2.0, was defined in the context of the Open Grid Forum. The implementation of the publication and use of the new schema is a complex process which needs to be carefully managed to avoid any disruption to the production service, especially in the light of the end of the EGEE project and the transition to the new middleware and operational structures in EGI. In this paper we discuss the LDAP rendering of the schema, the upgrading of the Grid information system to allow both schemas to be used in parallel, the design and rollout of information providers, and the plans for migrating client software which uses the schema information. In particular we consider the implications for the specific requirements of the LCG project, especially regarding storage systems, accounting and monitoring.

  13. Humidity control and hydrophilic glue coating applied to mounted protein crystals improves X-ray diffraction experiments

    Science.gov (United States)

    Baba, Seiki; Hoshino, Takeshi; Ito, Len; Kumasaka, Takashi

    2013-01-01

    Protein crystals are fragile, and it is sometimes difficult to find conditions suitable for handling and cryocooling the crystals before conducting X-ray diffraction experiments. To overcome this issue, a protein crystal-mounting method has been developed that involves a water-soluble polymer and controlled humid air that can adjust the moisture content of a mounted crystal. By coating crystals with polymer glue and exposing them to controlled humid air, the crystals were stable at room temperature and were cryocooled under optimized humidity. Moreover, the glue-coated crystals reproducibly showed gradual transformations of their lattice constants in response to a change in humidity; thus, using this method, a series of isomorphous crystals can be prepared. This technique is valuable when working on fragile protein crystals, including membrane proteins, and will also be useful for multi-crystal data collection. PMID:23999307

  14. Endovascular Treatment of Pseudoaneurysm of the Common Hepatic Artery with Intra-aneurysmal Glue (N-Butyl 2-Cyanoacrylate) Embolization

    International Nuclear Information System (INIS)

    Garg, Ashwin; Banait, Swati; Babhad, Sudeep; Kanchankar, Niraj; Nimade, Pradeep; Panchal, Chintan

    2007-01-01

    A 40-year-old man, a chronic alcoholic, presented with acute epigastric pain. Selective celiac arteriography showed a pseudoaneurysm arising from the common hepatic artery. We hereby describe a technical innovation where complete pseudoaneurysm exclusion was seen after intra-aneurysmal N-butyl 2-cyanoacrylate (glue) injection with preservation of antegrade hepatic arterial flow and conclude that intra-aneurysmal liquid injection may have potential as a therapeutic option to reconstruct a defective vessel wall and thereby maintain the antegrade flow

  15. Development of Self Fire Retardant Melamine-Animal Glue Formaldehyde (MGF) Resin for the Manufacture of BWR Ply Board

    Science.gov (United States)

    Khatua, Pijus Kanti; Dubey, Rajib Kumar; Roymahapatra, Gourisankar; Mishra, Anjan; Shahoo, Shadhu Charan; Kalawate, Aparna

    2017-10-01

    Wood is one of the most sustainable, naturally growing materials that consist mainly of combustible organic carbon compounds. Since plywood are widely used nowadays especially in buildings, furniture and cabinets. Too often the fire behavior of ply-board may be viewed as a drawback. Amino-plastic based thermosetting resin adhesives are the important and most widely used in the plywood panel industries. The fire retardant property of wood panel products by adding animal glue as an additive in the form of MGF resin and used as substitute of melamine for manufacture of plywood. Environment concerns and higher cost of petroleum based resins have resulted in the development of technologies to replace melamine partially by biomaterials for the manufacturing of resin adhesive. Natural bio-based materials such as tannin, CNSL (cardanol), lignin, soya etc. are used as partial substitution of melamine. This article presents the development of melamine-animal glue formaldehyde resin as plywood binder. About 30 % melamine was substituted by animal glue and optimized. The different physico-mechanical and fire retardant property properties tested as per IS: 1734-1983 and IS: 5509-2000 respectively are quite satisfactory. The production of adhesive from melamine with compatible natural proteinous material is cost effective, eco-friendly and enhance the fire retardant property.

  16. Transarterial microcatheter glue embolization of the bronchial artery for life-threatening hemoptysis: Technical and clinical results

    Energy Technology Data Exchange (ETDEWEB)

    Baltacioglu, Feyyaz [Marmara University School of Medicine, Department of Radiology, Istanbul (Turkey)], E-mail: fbaltaci@yahoo.com; Cimsit, Nuri Cagatay [Marmara University School of Medicine, Department of Radiology, Istanbul (Turkey)], E-mail: cagataycimsit@gmail.com; Bostanci, Korkut [Marmara University School of Medicine, Department of Thoracic Surgery, Istanbul (Turkey)], E-mail: kbostanci@marmara.edu.tr; Yueksel, Mustafa [Marmara University School of Medicine, Department of Thoracic Surgery, Istanbul (Turkey)], E-mail: myuksel@marmara.edu.tr; Kodalli, Nihat [Marmara University School of Medicine, Department of Radiology, Istanbul (Turkey)], E-mail: nihatkodalli@yahoo.com

    2010-02-15

    Objectives: To report our experience with transarterial glue embolization of the bronchial artery for life-threatening hemoptysis. Materials and methods: Twenty-five patients underwent bronchial artery embolization, using coaxial microcatheter technique, with a liquid agent, n-butyl-2-cyanoacrylate (NBCA), named glue, for life-threatening hemoptysis. The technical and clinical outcomes were followed in terms of immediate control of bleeding, recurrence of hemoptysis and complications of the procedure. Results: Four patients had acute hemoptysis when they were evaluated. The average number of arteries embolized per patient was 2.9. BAEs were successful in controlling hemoptysis immediately in all 25 patients (100%) and in 24 patients (96%) at 1 month follow-ups. One patient had recurrent hemoptysis on the tenth day after embolization. The follow-up time ranged from 2 to 63 months (mean 14 months). Six patients (25%) died all as a result of their disease process. Bleeding recurred in 3 patients after 30 days (7th, 11th, 12th months). One patient had vomitting attacks with dysphagia after the procedure that lasted 24 h. Three patients had transient thoracic pain lasting 3-5 days. There were no procedure related spinal or vascular complications. Conclusions: Glue embolization with microcatheter technique is a safe and effective treatment in cases of life-threatening hemoptysis with a very high rate of success and low rate of complications.

  17. Percutaneous sclerotherapy of massive macrocystic lymphatic malformations of the face and neck using fibrin glue with OK-432 and bleomycin.

    Science.gov (United States)

    Chen, W-l; Huang, Z-q; Chai, Q; Zhang, D-m; Wang, Y-y; Wang, H-j; Wang, L; Fan, S

    2011-06-01

    Picibanil (OK-432) and bleomycin have been used as alternative sclerosing agents for lymphatic malformations. This study evaluated the clinical curative effect of sclerotherapy using fibrin glue combined with OK-432 and bleomycin for the treatment of macrocystic lymphatic malformations of the face and neck. Fifteen paediatric patients (6 males; 9 females, aged 13 months to 14 years) who had received percutaneous sclerotherapy for massive macrocystic lymphatic malformations of the face and neck were retrospectively reviewed. Affected regions included the neck, parotid region and parapharynx, mouth floor, face and cheek, and orbital regions. All patients showed preoperative symptoms of space-occupying lesions between 4 cm × 5 cm and 12 cm × 16 cm in size. Fibrin glue with OK-432 and bleomycin was injected under general anaesthesia. All patients received preoperative and follow-up CT scans. Outcomes were assessed by three surgeons. All patients exhibited mid-facial swelling for 3-4 weeks after surgery, but no major complications. Follow-up periods ranged from 8 to 16 months. Eight lesions were completely involuted, five were mostly involuted, and two were partially involuted. Percutaneous sclerotherapy using fibrin glue with OK-432 and bleomycin provided a simple, safe, and reliable alternative treatment for massive macrocystic lymphatic malformations of the face and neck. Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  18. Effect of fibrin glue derived from snake venom on the viability of autogenous split-thickness skin graft

    Directory of Open Access Journals (Sweden)

    S.C. Rahal

    2004-01-01

    Full Text Available The aim of this study was to analyze the effect of snake venom derived from fibrin glue on the viability of split-thickness skin graft. Nine crossbreed dogs were used. Full-thickness skin segments measuring 4 x 4 cm were bilaterally excised from the proximal radial area on each dog. A split-thickness skin graft was harvestedfrom left lateral thoracic area using a freehand graft knife, and was secured to the left recipient bed using several simple interrupted sutures of 3-0 nylon (sutured graft. A split-thickness skin graft was harvested from the right lateral thoracic area using a graft knife. Fibrin glue derived from snake venom was applied to the recipient bed, and 8 equidistant simple interrupted sutures of 3-0 nylon were used to secure the skin graft (glued graft. Viable and nonviable areas were traced on a transparent sheet and measured using a Nikon Photomicroscope connected to a KS-300 image analysis system. The skin graft and recipient bed were collected from three dogs at day 7, 15, and 30 postoperative. The glued grafts had statistically higher graft viability than sutured grafts. Histological examination showed that the tissue repair process in the glued grafts was more accentuated than sutured grafts. It was possible to conclude that fibrin glue derived from snake venom increased survival of autogenous split-thickness skin graft.

  19. 2-octyl-cyanoacrylate glue for fixation of STSG in genitourinary tissue defects due to Fournier gangrene: a preliminary trial.

    Science.gov (United States)

    Sivrioğlu, Nazan; Irkören, Saime; Ceylan, Ender; Sonel, Ali Murat; Copçu, Eray

    2013-05-01

    In these reported cases, we observed the outcomes of skin take and wound healing using 2-octyl-cyanoacrylate glue, which was used as tissue glue in the reconstruction of complex genital skin loss due to fournier gangrene. Fifteen patients with Fournier's gangrene were treated in this study. After initial surgical debridement, all defects were repaired using STSG. In this method a thin layer of 2-octyl-cyanoacrylate was dripped on the recipient site immediately before graft application. All wounds were followed up postoperatively and observed for evidence of graft take, seroma or hematoma formation, drainage, and infection. Patient and physician satisfaction were also determined. Grafts were completely accepted in all fifteen patients. None of the patients had wound infection, seroma, hematoma, or other complications. Use of 2-octyl-cyanoacrylate glue (Glueseal) for STSG fixation in complex genital skin defects after Fournier gangrene may be an acceptable alternative to conventional surgical closure with a good cosmetic outcome. Further studies are needed to confirm our initial success with this approach.

  20. Humidity control and hydrophilic glue coating applied to mounted protein crystals improves X-ray diffraction experiments

    International Nuclear Information System (INIS)

    Baba, Seiki; Hoshino, Takeshi; Ito, Len; Kumasaka, Takashi

    2013-01-01

    A new crystal-mounting method has been developed that involves a combination of controlled humid air and polymer glue for crystal coating. This method is particularly useful when applied to fragile protein crystals that are known to be sensitive to subtle changes in their physicochemical environment. Protein crystals are fragile, and it is sometimes difficult to find conditions suitable for handling and cryocooling the crystals before conducting X-ray diffraction experiments. To overcome this issue, a protein crystal-mounting method has been developed that involves a water-soluble polymer and controlled humid air that can adjust the moisture content of a mounted crystal. By coating crystals with polymer glue and exposing them to controlled humid air, the crystals were stable at room temperature and were cryocooled under optimized humidity. Moreover, the glue-coated crystals reproducibly showed gradual transformations of their lattice constants in response to a change in humidity; thus, using this method, a series of isomorphous crystals can be prepared. This technique is valuable when working on fragile protein crystals, including membrane proteins, and will also be useful for multi-crystal data collection

  1. Humidity control and hydrophilic glue coating applied to mounted protein crystals improves X-ray diffraction experiments

    Energy Technology Data Exchange (ETDEWEB)

    Baba, Seiki; Hoshino, Takeshi; Ito, Len; Kumasaka, Takashi, E-mail: kumasaka@spring8.or.jp [Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 1-1-1 Kouto, Sayo, Hyogo 679-5198 (Japan)

    2013-09-01

    A new crystal-mounting method has been developed that involves a combination of controlled humid air and polymer glue for crystal coating. This method is particularly useful when applied to fragile protein crystals that are known to be sensitive to subtle changes in their physicochemical environment. Protein crystals are fragile, and it is sometimes difficult to find conditions suitable for handling and cryocooling the crystals before conducting X-ray diffraction experiments. To overcome this issue, a protein crystal-mounting method has been developed that involves a water-soluble polymer and controlled humid air that can adjust the moisture content of a mounted crystal. By coating crystals with polymer glue and exposing them to controlled humid air, the crystals were stable at room temperature and were cryocooled under optimized humidity. Moreover, the glue-coated crystals reproducibly showed gradual transformations of their lattice constants in response to a change in humidity; thus, using this method, a series of isomorphous crystals can be prepared. This technique is valuable when working on fragile protein crystals, including membrane proteins, and will also be useful for multi-crystal data collection.

  2. Experiences with the GLUE information schema in the LCG/EGEE production grid

    International Nuclear Information System (INIS)

    Burke, S; Andreozzi, S; Field, L

    2008-01-01

    A common information schema for the description of Grid resources and services is an essential requirement for interoperating Grid infrastructures, and its implementation interacts with every Grid component. In this context, the GLUE information schema was originally defined in 2002 as a joint project between the European DataGrid and DataTAG projects and the US iVDGL. The schema has major components to describe Computing and Storage Elements, and also generic Service and Site information. It has been used extensively in the LCG/EGEE Grid, for job submission, data management, service discovery and monitoring. In this paper we present the experience gained over the last five years, highlighting both successes and problems. In particular, we consider the importance of having a clear definition of schema attributes; the construction of standard information providers and difficulties encountered in mapping an abstract schema to diverse real systems; the configuration of publication in a way which suits system managers and the varying characteristics of Grid sites; the validation of published information; the ways in which information can be used (and misused) by Grid services and users; and issues related to managing schema upgrades in a large distributed system

  3. GlueX: The Search for Gluonic Excitations at Jefferson Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    D.S. Carman

    2005-08-21

    One of the unanswered and most fundamental questions in physics regards the nature of the confinement mechanism of quarks and gluons in quantum chromodynamics (QCD). Exotic hybrid mesons manifest gluonic degrees of freedom and their detailed spectroscopy will provide the precision data necessary to test assumptions in lattice QCD and the specific phenomenology leading to confinement. Photoproduction is expected to be a particularly effective manner to produce exotic hybrids, however, existing data using photon beams are sparse. At Jefferson Laboratory, plans are underway by the GlueX Collaboration to use the coherent bremsstrahlung technique to produce a linearly polarized photon beam. A solenoid-based hermetic detector will be used to collect data on meson production and decays with statistics that will exceed existing photoproduction data by several orders of magnitude after the first year of running. In order to reach the ideal photon energy of 9 GeV required for these studies, the energy of the Jefferson Laboratory electron accelerator, CEBAF, will be doubled from its current maximum energy of 6 GeV to 12 GeV. The physics motivating the search and the status of the project are reviewed.

  4. Calibrations for charged particle tracking and measurements of w photoproduction with the GlueX detector

    Energy Technology Data Exchange (ETDEWEB)

    Staib, Michael [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2017-09-21

    The GlueX experiment is a new experimental facility at Jefferson Lab in Newport News, VA. The experiment aims to map out the spectrum of hybrid mesons in the light quark sector. Measurements of the spin-density matrix elements in omega photoproduction are performed with a linear polarized photon beam on an unpolarized proton target, and presented in bins of Mandelstam t for beam energies of 8.4-9.0 GeV. The spin-density matrix elements are exclusively measured through two decays of the omega meson: omega -> pi^+ pi^- pi^0 and omega ->pi^0 gamma. A description of the experimental apparatus is presented. Several methods used in the calibration of the charged particle tracking system are described. These measurements greatly improve the world statistics in this energy range. These are the first results measured through the omega ->pi^0 gamma decay at this energy. Results are generally consistent with a theoretical model based on diffractive production with Pomeron and pseudoscalar exchange in the t-channel.

  5. Experimental study on the viscosity and adhesive performance of exogenous liquid fibrin glue.

    Science.gov (United States)

    Hayashi, Takuro; Hasegawa, Mitsuhiro; Inamasu, Joji; Adachi, Kazuhide; Nagahisa, Shinya; Hirose, Yuichi

    2014-01-01

    Exogenous fibrin glue (FG) is highly suitable for neurosurgical procedures, because of its viscosity and adhesive properties. Several FGs are commercially available, but only few reports detail their differences. In the present study, we investigated the viscosity and adhesive performance of two types of FG: one is derived from blood donated in Europe and the United States (CSL Behring's Beriplast(®), BP) and the other is derived from blood donated in Japan (the Chemo-Sero-Therapeutic Research Institute's Bolheal(®), BH). The viscosity test that measured fibrinogen viscosity revealed that BP had significantly higher viscosity than BH. Similarly, the dripping test showed that BP traveled a significantly shorter drip distance in the vertical direction than BH, although the transverse diameter of the coagulated FG did not differ statistically significantly. In the tensile strength test, BP showed superior adhesion performance over BH. The histological study of the hematoxylin-eosin-stained specimens in both groups showed favorable adhesion. Although further studies are required on its manufacturing and usage methods, FG shows differences in viscosity and adhesive performance according to the blood from which it is derived. We conclude that it is desirable to select the type and usage method of FG according to the characteristics of the surgical operation in question. Our findings suggest that FG produced from the blood donated in Europe and the United States might be more suitable for use in surgical procedures that demand an especially high degree of viscosity and rapid adhesive performance.

  6. Endoscopic ultrasound-guided coil or glue injection in post-cyanoacrylate gastric variceal re-bleed.

    Science.gov (United States)

    Mukkada, Roy J; Antony, Rajesh; Chooracken, Mathew J; Francis, Jose V; Chettupuzha, Antony P; Mathew, Pradeep G; Augustine, Philip; Koshy, Abraham

    2018-04-09

    N-butyl-cyanoacrylate injection is recommended in bleeding/recently bled gastric varices. However, cyanoacrylate injection is associated with re-bleed in 25% to 50% of patients. Endoscopic ultrasound (EUS)-guided coil application is an emerging treatment modality for bleeding gastric varices. The aim of this study was to compare EUS-guided coil application combined with or without cyanoacrylate glue injection to injection alone in post-glue gastric variceal re-bleed. A retrospective analysis of a prospectively maintained database was performed. Thirty patients who re-bled after cyanoacrylate injection and who had EUS-guided coil application to gastric varices were included. The comparison was done with data of 51 patients who had only repeat cyanoacrylate injection. Both groups had a follow up for 12 months. EUS-guided coil application was done under endosonographic guidance. A single coil was placed in 7, two coils in each of 13 patients, three in 5, four in 3, five in one, and 6 coils in one patient. In addition, cyanoacrylate glue injection was given in 15 patients. Eight patients had repeat EUS-guided coil application 1 month later. Re-bleed and mortality were assessed. Coilng: Six out of 30 (20%) patients re-bled during follow up of 9 to 365 days. Three out of 30 (10%) died. One patient died 9 days after the procedure due to acute respiratory distress syndrome, one died 4 months after the procedure due to a re-bleed and one 5 months after the procedure due to spontaneous bacterial peritonitis. Glue only: 26/51 (51%) re-bled during follow up of 45 to 365 days. EUS-guided coil application resulted in significantly less re-bleed than glue-only (Kaplan-Meir survival analysis with log-rank test, z = 5.4, p guided coil application with/without cyanoacrylate injection for the obliteration of gastric varices is effective for post-cyanoacrylate gastric variceal re-bleed.

  7. Equifinality of formal (DREAM) and informal (GLUE) Bayesian approaches in hydrologic modeling?

    NARCIS (Netherlands)

    Vrugt, J.A.; ter Braak, C.J.F.; Gupta, H.V.; Robinson, B.A.

    2009-01-01

    In recent years, a strong debate has emerged in the hydrologic literature regarding what constitutes an appropriate framework for uncertainty estimation. Particularly, there is strong disagreement whether an uncertainty framework should have its roots within a proper statistical (Bayesian) context,

  8. Generative Semantics.

    Science.gov (United States)

    King, Margaret

    The first section of this paper deals with the attempts within the framework of transformational grammar to make semantics a systematic part of linguistic description, and outlines the characteristics of the generative semantics position. The second section takes a critical look at generative semantics in its later manifestations, and makes a case…

  9. Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells

    Directory of Open Access Journals (Sweden)

    Tamer Anwar Esmail Ahmed

    2015-02-01

    Full Text Available The retina is a highly sophisticated piece of the neural machinery that begins the translation of incoming light signals into meaningful visual information. Several degenerative diseases of the retina are characterized by photoreceptor loss and eventually lead to irreversible blindness. Regenerative medicine, using tissue engineering-based constructs to deliver progenitor cells or photoreceptors along with supporting carrier matrix is a promising approach for restoration of structure and function. Fresh fibrin glue (FG produced by the CryoSeal®FS system in combination with mouse retinal progenitor cells (RPCs were evaluated in this study. In vitro expanded RPCs isolated from postnatal mouse retina were encapsulated into FG and cultured in the presence of the protease inhibitor, tranexamic acid. Encapsulation of RPCs into FG did not show adverse effects on cell proliferation or cell survival. RPCs exhibited fibroblast-like morphology concomitantly with attachment to the encapsulating FG surface. They expressed α7 and β3 integrin subunits that could mediate attachment to fibrin matrix via an RGD independent mechanism. The three dimensional environment and the attachment surface provided by FG was associated with a rapid downregulation of the progenitor marker SOX2 and enhanced the expression of the differentiation markers CRX and recoverin. However, the in vitro culture conditions did not promote full differentiation into mature photoreceptors. Nevertheless, we have shown that autologous fibrin, when fabricated into a scaffold for RPCs for delivery to the retina, provides the cells with external cues that could potentially improve the differentiation events. Hence, transient encapsulation of RPCs into FG could be a valid and potential treatment strategy to promote retinal regeneration following degenerative diseases. However, further optimization is necessary to maximize the outcomes in terms of mature photoreceptors.

  10. Assessing Civic Competency and Engagement in Higher Education: Research Background, Frameworks, and Directions for Next-Generation Assessment. Research Report. ETS RR-15-34

    Science.gov (United States)

    Torney-Purta, Judith; Cabrera, Julio C.; Roohr, Katrina Crotts; Liu, Ou Lydia; Rios, Joseph A.

    2015-01-01

    Civic learning is increasingly recognized as important by the higher education and workforce communities. The development of high-quality assessments that can be used to evaluate students' civic learning during the college years has become a priority. This paper presents a comprehensive review of existing frameworks, definitions, and assessments…

  11. Staple line reinforcement with fleece-coated fibrin glue (TachoComb) after thoracoscopic bullectomy for the treatment of spontaneous pneumothorax

    International Nuclear Information System (INIS)

    Muramatsu, Takashi; Ohmori, Kazumitsu; Shimamura, Mie; Furuichi, Motohiko; Takeshita, Shinji; Negishi, Nanao

    2007-01-01

    We investigated the cause of pneumothorax recurrence after thoracoscopic surgery and the effectiveness of staple line reinforcement with fleece-coated fibrin glue (TachoComb) in the prevention of postoperative pneumothorax recurrence. From April 3, 1992 to the end of December 2005, thoracoscopic bullectomy was performed on 499 patients of primary spontaneous pneumothorax. The causes of recurrence were investigated on 39 patients on the basis of surgical observations, preoperative chest computed tomography, and so on. The most common cause was new bulla formation (37 cases), 19 of which were apparently related to the staple line (within 1 cm of the staple lines) and 15 of which were not related to the staple line. After 2000, we stopped using forceps to grasp lungs and we have reinforced the staple line by applying fleece-coated fibrin glue. The staple line reinforced with fleece-coated fibrin glue, or sprayed with fibrin glue solution and the untreated group (bullectomy only with staples) were compared, and the recurrence rates were 1.22%, 7.25%, and 10.00%, respectively (P=0.0006021). The recurrence rate after thoracoscopic bullectomy with fleece-coated fibrin glue was significantly lowered and we consider this procedure to be the treatment of choice for the management of spontaneous pneumothorax. (author)

  12. Evaluating Uncertainty of Runoff Simulation using SWAT model of the Feilaixia Watershed in China Based on the GLUE Method

    Science.gov (United States)

    Chen, X.; Huang, G.

    2017-12-01

    In recent years, distributed hydrological models have been widely used in storm water management, water resources protection and so on. Therefore, how to evaluate the uncertainty of the model reasonably and efficiently becomes a hot topic today. In this paper, the soil and water assessment tool (SWAT) model is constructed for the study area of China's Feilaixia watershed, and the uncertainty of the runoff simulation is analyzed by GLUE method deeply. Taking the initial parameter range of GLUE method as the research core, the influence of different initial parameter ranges on model uncertainty is studied. In this paper, two sets of parameter ranges are chosen as the object of study, the first one (range 1) is recommended by SWAT-CUP and the second one (range 2) is calibrated by SUFI-2. The results showed that under the same number of simulations (10,000 times), the overall uncertainty obtained by the range 2 is less than the range 1. Specifically, the "behavioral" parameter sets for the range 2 is 10000 and for the range 1 is 4448. In the calibration and the validation, the ratio of P-factor to R-factor for range 1 is 1.387 and 1.391, and for range 2 is 1.405 and 1.462 respectively. In addition, the simulation result of range 2 is better with the NS and R2 slightly higher than range 1. Therefore, it can be concluded that using the parameter range calibrated by SUFI-2 as the initial parameter range for the GLUE is a way to effectively capture and evaluate the simulation uncertainty.

  13. Gas chromatography-mass spectrometry characterization of the varnish and glue of an ancient 18th century double bass.

    Science.gov (United States)

    Caruso, Francesco; Orecchio, Santino; Cicero, Maria Grazia; Di Stefano, Cosimo

    2007-04-20

    A GC-MS investigation is conducted on the double bass "Panormus", property of Conservatorio di Musica "Vincenzo Bellini" in Palermo. The most important components of the varnish (fatty acids) and of the glue (proteinaceous amino acids), with which the musical instrument was treated in the past, are determined. The analyses are carried out by prior derivatization of fatty acids by acidic methanol and of amino acids by acidic methanol and trifluoroacetic anhydride (TFAA). Analytes identification is achieved by direct comparison with several reference materials and the use of a digitized library.

  14. Pancreatic fistula after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis: effect of fibrin glue and polyglycolic acid felt on prophylaxis of postoperative complications.

    Science.gov (United States)

    Tsutsumi, Norifumi; Tomikawa, Morimasa; Akahoshi, Tomohiko; Kawanaka, Hirofumi; Ota, Mitsuhiko; Sakaguchi, Yoshihisa; Kusumoto, Tetsuya; Ikejiri, Koji; Hashizume, Makoto; Maehara, Yoshihiko

    2016-11-01

    This study aimed to determine the effect of fibrin glue and polyglycolic acid (PGA) felt on prevention of pancreatic fistula (PF) after laparoscopic splenectomy in patients with hypersplenism due to liver cirrhosis. Fifty consecutive patients were enrolled in this prospective study. Twenty-three patients underwent laparoscopic splenectomy with a fibrin sheet (fibrin sheet group). The sealing ability of each treatment was evaluated by an ex vivo pressure test model. Based on the results from ex vivo experiments, 27 patients received prophylaxis using fibrin glue and PGA felt (PGA with fibrin group). The primary endpoint was the incidence of PF. Significantly more (5, 22%) patients developed PF in the fibrin sheet group than in the PGA with fibrin group (0%, P = .037). Our new application of fibrin glue and PGA felt is an effective prophylactic procedure for preventing development of PF after laparoscopic splenectomy. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. [The advantages in using cyanoacrylate glue over skin staples as a method of skin graft fixation in the pediatric burns population].

    Science.gov (United States)

    Curings, P; Vincent, P-L; Viard, R; Gir, P; Comparin, J-P; Voulliaume, D

    2017-11-23

    Local postoperative care and burn wound management can present with a certain degree of difficulty in the pediatric population. While the use of skin staples as a method of skin graft fixation is a well-known, rapid and simple method, their removal can be painful and may necessitate some sedation or even general anesthesia. We studied in this article the advantages and economic value of using the cyanoacrylate glue as a fixation method for skin grafts. A comparative study was carried out from 2012 to 2016. Hundred and eighteen infants with burns up to 5% of total body surface area were included in the study. Seventy-two infants had split thickness skin grafts fixed with skin staples. Forty-six infants had split thickness skin grafts fixed with cyanoacrylate glue. We compared the quality of graft, the sedation used during the first postoperative dressing, the length of hospital stay, the amount of glue used and the presence of complications. There is a difference between the two groups studied in terms of age and total burn surface area. The rate of graft take was 100% in both groups. The first postoperative dressing was carried out without the use of powerful analgesia in the cyanoacrylate group, while it was necessary to use general anesthesia in 64% of the skin staples group. The average length of stay in hospital after skin grafting was 4.9 days for the cyanoacrylate glue versus 6.5 days in the skin staples group. No complications were noted in the 2 groups. The use of cyanoacrylate glue allows rapid fixation of skin grafts and avoid general anesthesia for postoperative cares. Subsequently the length of hospital stay is reduced within 25%. The medico-economic value of glue protocol is highly significant compared to skin staples, while having similar good results and without significant problems. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  16. Successful management with glue injection of arterial rupture seen during embolization of an arteriovenous malformation using a flow-directed catheter: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jong Won; Baik, Seung Kug; Shin, Mi Jung; Choi, Han Yong; Kim, Bong Gi [Wallace Memorial Baptist Hospital, Pusan (Korea, Republic of)

    2000-12-01

    We present a case in which an arterial rupture occurring during embolization of an arteriovenous malformation of the left occipital lobe with a flow-directed micro-catheter, was successfully sealed with a small amount of glue. We navigated a 1.8-Fr Magic catheter through the posterior cerebral artery, and during superselective test injection, extravasation was observed at the parieto-occipital branch. The catheter was not removed and the perforation site was successfully sealed with a small amount of glue injected through the same catheter. Prompt recognition and closure of the perforation site is essential for good prognosis. (author)

  17. In search of low cost biological analysis: Wax or acrylic glue bonded paper microfluidic devices

    KAUST Repository

    Kodzius, Rimantas

    2011-01-22

    In this body of work we have been developing and characterizing paper based microfluidic fabrication technologies to produce low cost biological analysis. Specifically we investigated the performance of paper microfluidics that had been bonded using wax or acrylic glue, and characterized the affect of these and other microfluidic materials on the polymerase chain reaction (PCR). We report a simple, low-cost and detachable microfluidic chip incorporating easily accessible paper, glass slides or other polymer films as the chip materials along with adhesive wax or cyanoacrylate-based resin as the recycling bonding material. We use a laser to cut through the paper or film to form patterns and then sandwich the paper and film between glass sheets or polymer membranes. The hot-melt adhesive wax or simple cyanoacrylate-based resin can realize bridge bonding between various materials, for example, paper, polymethylmethacrylate film, glass sheets, or metal plate. The wax bonding process is reversible and the wax is reusable through a melting and cooling process. With this process, a three-dimensional (3D) microfluidic chip is achievable by evacuating the channels of adhesive material in a hot-water. We applied the wax-paper based microfluidic chip to HeLa cell electroporation. Subsequently, a prototype of a 5-layer 3D chip was fabricated by multilayer wax bonding. To check the sealing ability and the durability of the chip, green fluorescence protein recombinant E. coli bacteria were cultured, with which the chemotaxis of E. coli was studied in order to determine the influence of antibiotic ciprofloxacin concentration on the E. coli migration. The chip bonded with cyanoacrylate-based resin was tested by measuring protein concentration and carrying out DNA capillary electrophoresis. To study the biocompatibility and applicability of our microfluidic chip fabrication technology, we tested the PCR compatibility of our chip materials along with various other common materials

  18. Need to Knowledge (NtK) Model: an evidence-based framework for generating technological innovations with socio-economic impacts.

    Science.gov (United States)

    Flagg, Jennifer L; Lane, Joseph P; Lockett, Michelle M

    2013-02-15

    Traditional government policies suggest that upstream investment in scientific research is necessary and sufficient to generate technological innovations. The expected downstream beneficial socio-economic impacts are presumed to occur through non-government market mechanisms. However, there is little quantitative evidence for such a direct and formulaic relationship between public investment at the input end and marketplace benefits at the impact end. Instead, the literature demonstrates that the technological innovation process involves a complex interaction between multiple sectors, methods, and stakeholders. The authors theorize that accomplishing the full process of technological innovation in a deliberate and systematic manner requires an operational-level model encompassing three underlying methods, each designed to generate knowledge outputs in different states: scientific research generates conceptual discoveries; engineering development generates prototype inventions; and industrial production generates commercial innovations. Given the critical roles of engineering and business, the entire innovation process should continuously consider the practical requirements and constraints of the commercial marketplace.The Need to Knowledge (NtK) Model encompasses the activities required to successfully generate innovations, along with associated strategies for effectively communicating knowledge outputs in all three states to the various stakeholders involved. It is intentionally grounded in evidence drawn from academic analysis to facilitate objective and quantitative scrutiny, and industry best practices to enable practical application. The Need to Knowledge (NtK) Model offers a practical, market-oriented approach that avoids the gaps, constraints and inefficiencies inherent in undirected activities and disconnected sectors. The NtK Model is a means to realizing increased returns on public investments in those science and technology programs expressly intended to

  19. Effects of diode laser welding with dye-enhanced glue on tensile strength of sutures commonly used in urology.

    Science.gov (United States)

    Kirsch, A J; Chang, D T; Kayton, M L; Libutti, S K; Connor, J P; Hensle, T W

    1996-01-01

    Tissue welding using laser-activated protein solders may soon become an alternative to sutured tissue approximation. In most cases, approximating sutures are used both to align tissue edges and provide added tensile strength. Collateral thermal injury, however, may cause disruption of tissue alignment and weaken the tensile strength of sutures. The objective of this study was to evaluate the effect of laser welding on the tensile strength of suture materials used in urologic surgery. Eleven types of sutures were exposed to diode laser energy (power density = 15.9 W/cm2) for 10, 30, and 60 seconds. Each suture was compared with and without the addition of dye-enhanced albumin-based solder. After exposure, each suture material was strained (2"/min) until ultimate breakage on a tensometer and compared to untreated sutures using ANOVA. The strength of undyed sutures were not significantly affected; however, violet and green-dyed sutures were in general weakened by laser exposure in the presence of dye-enhanced glue. Laser activation of the smallest caliber, dyed sutures (7-0) in the presence of glue caused the most significant loss of tensile strength of all sutures tested. These results indicate that the thermal effects of laser welding using our technique decrease the tensile strength of dyed sutures. A thermally resistant suture material (undyed or clear) may prevent disruption of wounds closed by laser welding techniques.

  20. Treatment for intractable anemia with the traditional Chinese medicines Hominis Placenta and Cervi Cornus Colla (deer antler glue

    Directory of Open Access Journals (Sweden)

    Yasuyo Hijikata

    2009-05-01

    Full Text Available Yasuyo Hijikata1, Takashi Kano2, Lu Xi31Toyodo Hijikata Clinic, Osaka, Japan; 2Kano Clinic, Osaka city, Osaka, Japan; 3Traditional Chinese Medicine Institute, Si-chuan Province, ChinaObjective: Intractable anemia, such as aplastic anemia or that presumably associated with chronic herpes virus infections, sometimes require bone marrow transplant. We investigated the use of traditional Chinese medicine (TCM for the treatment of intractable anemia. Method: Placenta Hominis (PH, steam boiled and roasted, and Cervi Cornus Colla (deer antler glue has been used in China for hundreds of years to treat anemia. After consent was obtained, we prescribed these two materials for a 74-year-old female with aplastic anemia and a 26-year-old male with presumably a virus-induced anemia. Concomitant conventional therapy was continued in both patients as prescribed by their respective attending physicians. Conclusion: Conventional therapy with steroid hormones, immunosuppressive drugs, platelet and erythrocyte transfusions were not effective in these patients. In addition, both patients suffered from serious side effects. In two patients, ingestion of Placenta Hominis and Cervi Cornus Colla with TCM prescriptions increased the platelet and enhanced the hemoglobin concentration in several months of therapy accompanied by a dramatic improvement in quality of life. The addition to conventional therapy of PH and Cervi Cornus Colla, the latter of which is very easy to obtain, may be one of the potentially advantageous choices in case of otherwise intractable anemia.Keywords: placenta, antler glue, Cervi Cornus Colla, anemia, aplastic anemia

  1. Boll weevil within season and off-season activity monitored using a pheromone-and-glue reusable tube trap

    Directory of Open Access Journals (Sweden)

    Robério Carlos dos Santos Neves

    Full Text Available ABSTRACT: The boll weevil colonizes cotton fields as early as cotton squaring, causing significant losses due to feeding and protected development inside fruiting structures throughout crop phenology. Successful control depends on control of adults and their accurate detection when they colonize the crops. The commercial trap and boll weevil attract-and-control tubes (BWACT are the only available tools to monitor and attract-and-kill boll weevil, despite limitation in efficacy, and insecticide in BWACT is not allowed in organic production. A grandlure-and-glue reusable and insecticide-free tube (GGT made with polyvinyl chloride tube, smeared with entomological glue, and lured with pheromone was tested to detect boll weevil activity across various seasons. Boll weevil showed activity during growing season and off-season from 2009 to 2012 in the Semiarid and with higher numbers captured in GGT in comparisons to commercial traps. GGT was able to detect early weevils in the field right after planting. Further, the overall averages resulted in 34-, 16.8-, and 7.5-times more weevils captured in GGTs compared to the traps during stalk destruction in the Semiarid 2011 and Cerrado season 2012/13 and during the harvesting period in the Cerrado season 2011/12, respectively. Therefore, boll weevils were captured actively during season and off-season and early captures obtained in GGT compared to traps showed a better correlation between captures and square damage.

  2. 3D Rare earth porous coordination frameworks with formamide generated in situ syntheses: Crystal structure and down- and up-conversion luminescence

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Xue [Department of Chemistry, Capital Normal University, Beijing 100048 (China); Tian, Jing [Department of Chemistry, Capital Normal University, Beijing 100048 (China); Experiment and Teaching Resource Management Centre, Yibin University, Yibin, 644000 (China); Yang, Hong-Y.; Zhao, Kai [Department of Chemistry, Capital Normal University, Beijing 100048 (China); Li, Xia, E-mail: xiali@mail.cnu.edu.cn [Department of Chemistry, Capital Normal University, Beijing 100048 (China)

    2013-05-01

    The reaction of RE(NO)₃·6H₂O and formamide yielded the coordination polymers, [RE(HCOO)₄]⁻[NH₂CHNH₂]⁺ (RE=Y 1, Eu 2, Gd 3, Tb 4, Dy 5, Er 6, and Yb 7). They possess 3D porous frameworks with the 1D rhombic channels occupied by [NH₂CHNH₂]⁺ cations. Complexes 2 and 4 display the characteristic down-conversion emissions corresponding to ⁵D₀→⁷FJ (J=1–4) transitions of Eu(III) ion and ⁵D₄→⁷FJ (J=6–3) transitions of Tb(III) ion, respectively. Longer lifetime values of 2.128±0.002 ms (⁵D₀) for 2 and 2.132±0.002 ms (⁵D₄) for 4 have been observed. The up-conversion spectra of the Y:Yb,Er and Gd:Yb,Er codoped complexes exhibit three emission bands around 410 (⁴H9/2→⁴I15/2, blue), 518–570 (⁴S3/2, ²H11/2→⁴I15/2, green), and 655 nm (⁴F9/2→⁴I15/2, red). - Graphical Abstract: The complexes [RE(HCOO)₄]⁻[NH₂CHNH₂]⁺ possess 3D porous frameworks. Eu(III) and Tb(III) complexes show characteristic emission of Ln(III) ions. The up-conversion emission of the Y:Yb,Er and Gd:Yb,Er codoped complexes was observed. Highlights: •The reaction of RE(NO)₃·6H₂O and formamide produced complexes [RE(HCOO)₄]⁻[NH₂CHNH₂]⁺. • The complexes possess 3D frameworks with the 1D channels occupied by [NH₂CHNH₂]+ cations. • Eu(III)/Tb(III) complexes display the characteristic down-conversion emission of Ln(III) ions. • The Y:Yb,Er and Gd:Yb,Er doped complexes exhibit the up-conversion emission.

  3. The Impact of Adapting a General Professional Development Framework to the Constraints of In-Service Professional Development on the Next Generation Science Standards in Urban Settings

    Science.gov (United States)

    McGee, Steven; Nutakki, Nivedita

    2017-01-01

    Urban school districts face a dilemma in providing professional development support for teachers in transition to the Next Generation Science Standards (NGSS). Districts need to maximize the quality and amount of professional development within practical funding constraints. In this paper, we discuss preliminary results from a…

  4. Bridging the gap between GLUE and formal statistical approaches: approximate Bayesian computation

    NARCIS (Netherlands)

    Sadegh, M.; Vrugt, J.A.

    2013-01-01

    In recent years, a strong debate has emerged in the hydrologic literature regarding how to properly treat nontraditional error residual distributions and quantify parameter and predictive uncertainty. Particularly, there is strong disagreement whether such uncertainty framework should have its roots

  5. Plasma biomarker analysis in pediatric ARDS: generating future framework from a pilot randomized control trial of methylprednisoloneA framework for identifying plasma biomarkers related to clinical outcomes in pediatric ARDS

    Directory of Open Access Journals (Sweden)

    Dai eKimura

    2016-03-01

    .016 and Ang-2 levels (r=0.79, p=0.036 in the placebo group, and inversely correlated with Day 7 sICAM-1 levels (r=-0.91, p=0.005 in the MPT group.Conclusion: Biomarkers selected from endothelial, epithelial, or intravascular factors can be correlated with clinical endpoints in pediatric ARDS. For example, MPT could reduce neutrophil activation (MMP-8, decrease endothelial injury (sICAM-1 and allow epithelial recovery (sRAGE. Large ARDS clinical trials should develop similar frameworks.

  6. Re: Fibrin Glue Injections: A Minimally Invasive and Cost-Effective Treatment for Post-Renal Transplant Lymphoceles and Lymph Fistulas

    Directory of Open Access Journals (Sweden)

    Presser N

    2016-03-01

    Full Text Available In this retrospective study, 46 (2.7% patients out of 1662 kidney transplant recipients had developed symptomatic lymphocele/lymph fistula requiring intervention over an 11-year period. Open surgical drainage (22, laparoscopic surgical drainage (11 and percutaneous fibrin glue injections into the drained lymphocele cavity (13 were used to treat this complication. Besides being effective both on the early and late developed lymphoceles, significantly lower recurrence rates by fibrin glue injections and lower median treatment costs were observed when compared with the other two surgical modalities. It has also the advantage of an outpatient procedure that can be performed using fluoroscopic guidance, under local anesthesia. However, due to era effect, most of the open and laparoscopic surgical recipients were treated with sirolimus, a well-known antiproliferative immunosuppressive agent, which can promote development of lymphoceles and surgical failure. However, the majority of fibrin glue-treated cases were with tacrolimus-based regimens, but this study, in its nature, is far from giving the answer for decreased number of recurrences with fibrin glue

  7. Improved distal distribution of n-butyl cyanoacrylate glue by simultaneous injection of dextrose 5% through the guiding catheter: technical note

    International Nuclear Information System (INIS)

    Moore, Carolyn; Murphy, Kieran; Gailloud, Philippe

    2006-01-01

    The use of n-butyl cyanoacrylate (NBCA) as an adhesive agent for embolization of high-flow intracranial and extracranial vascular lesions is well established. To be successful, the embolization of arteriovenous malformations and fistulas must achieve obliteration of the arteriovenous shunts themselves rather than simply occlude the feeders proximal to the lesion. However, the feeders cannot always be negotiated over their entire length. This is often the case with dural arteriovenous fistulas (DAVF), which are usually vascularized by long and intricate meningeal networks. In such situations, NBCA may not be able to reach the lesion itself, rendering the embolization ineffective. We present a new technique that improves distal distribution of NBCA glue. The technique described in this report consists of injecting dextrose 5% through the guiding catheter simultaneously with the superselective injection of NBCA glue into the targeted feeding branch. The technique is illustrated with three cases of posterior fossa DAVF. In the reported cases, flooding the territory of the targeted vessel with non-ionic dextrose 5% allowed deep progression of the glue by delaying contact with ionic substances. Excellent distribution of the NBCA glue reaching the site of the arteriovenous shunts was thus obtained despite suboptimal proximal microcatheter tip positions. (orig.)

  8. Alternative glues for the production of ATLAS silicon strip modules for the Phase-II upgrade of the ATLAS Inner Detector

    CERN Document Server

    INSPIRE-00407830; Bloch, Ingo; Edwards, Sam; Friedrich, Conrad; Gregor, Ingrid M.; Jones, T; Lacker, Heiko; Pyatt, Simon; Rehnisch, Laura; Sperlich, Dennis; Wilson, John

    2016-05-24

    The Phase-II upgrade of the ATLAS detector for the High Luminosity Large Hadron Collider (HL-LHC) includes the replacement of the current Inner Detector with an all-silicon tracker consisting of pixel and strip detectors. The current Phase-II detector layout requires the construction of 20,000 strip detector modules consisting of sensor, circuit boards and readout chips, which are connected mechanically using adhesives. The adhesive between readout chips and circuit board is a silver epoxy glue as was used in the current ATLAS SemiConductor Tracker (SCT). This glue has several disadvantages, which motivated the search for an alternative. This paper presents a study concerning the use of six ultra-violet (UV) cure glues and a glue pad for use in the assembly of silicon strip detector modules for the ATLAS upgrade. Trials were carried out to determine the ease of use, the thermal conduction and shear strength, thermal cycling, radiation hardness, corrosion resistance and shear strength tests. These investigatio...

  9. Analysis of stress- strain distribution of dowel and glue line in L-type furniture joint by means of finite element method

    Directory of Open Access Journals (Sweden)

    mossayeb dalvand

    2017-08-01

    Full Text Available In this study 3D stress-strain distribution of dowel and glue line on L-type joints made of plywood doweled was investigated. Members of joints made of 11-ply hardwood plywood (Hornbeam, Beech and Alder that were 19 mm in thickness. In this study effect of beech dowels in three levels diameters (6, 8 and 10 mm and penetration of depth (9, 13 and 17 mm on bending moment capacity of L-type joints under compression loading was investigated as experimental test, then stress-strain distribution of wood dowel and glue line in specimens were simulated by means of ANSYS 15 software with finite element method (FEM.Results have shown that bending moment resistance increased with increasing dowel diameter from 6 to 8 mm, but downward trend was observed with increasing 8 to 10 mm in dowel diameter. Bending moment resistance increased with increasing penetration depth. Also, result obtained of simulation by means of ANSYS software have shown that stress-strain in dowel and glue line increased with increasing diameter of dowel and Increasing stress in joints made of diameter dowel 10 mm due to fracture in joints and decrease in resistance once. According to results obtained of model analysis, the ultimate stress of dowel and glue line occurred in the area that joints were contacted.

  10. Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers: experimental study in dogs (Canis familiaris, Linnaeus, 1758

    Directory of Open Access Journals (Sweden)

    R. L. Sampaio

    2007-01-01

    Full Text Available Fibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth. Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing.

  11. Smart microgrid hierarchical frequency control ancillary service provision based on virtual inertia concept: An integrated demand response and droop controlled distributed generation framework

    International Nuclear Information System (INIS)

    Rezaei, Navid; Kalantar, Mohsen

    2015-01-01

    Highlights: • Detailed formulation of the microgrid static and dynamic securities based on droop control and virtual inertia concepts. • Constructing a novel objective function using frequency excursion and rate of change of frequency profiles. • Ensuring the microgrid security subject to the microgrid economic and environmental policies. • Coordinated management of demand response and droop controlled distributed generation resources. • Precise scheduling of day-ahead hierarchical frequency control ancillary services using a scenario based stochastic programming. - Abstract: Low inertia stack, high penetration levels of renewable energy source and great ratio of power deviations in a small power delivery system put microgrid frequency at risk of instability. On the basis of the close coupling between the microgrid frequency and system security requirements, procurement of adequate ancillary services from cost-effective and environmental friendly resources is a great challenge requests an efficient energy management system. Motivated by this need, this paper presents a novel energy management system that is aimed to coordinately manage the demand response and distributed generation resources. The proposed approach is carried out by constructing a hierarchical frequency control structure in which the frequency dependent control functions of the microgrid components are modeled comprehensively. On the basis of the derived modeling, both the static and dynamic frequency securities of an islanded microgrid are provided in primary and secondary control levels. Besides, to cope with the low inertia stack of islanded microgrids, novel virtual inertia concept is devised based on the precise modeling of droop controlled distributed generation resources. The proposed approach is applied to typical test microgrid. Energy and hierarchical reserve resource are scheduled precisely using a scenario-based stochastic programming methodology. Moreover, analyzing the

  12. Management of an extrasphincteric fistula in an HIV-positive patient by using fibrin glue: a case report with tips and tricks

    Directory of Open Access Journals (Sweden)

    Sapalidis Konstantinos

    2010-02-01

    Full Text Available Abstract Background Individuals with impaired immunity are at higher risk of perianal diseases. Concerning complex anal fistulas impaired healing and complication rates are also higher. Definitive treatment of a fistula aims controlling the purulent discharge and prevents its recurrence. It depends mainly on the trajectory of the fistula and the underlying disease. We present a case of a HIV-positive patient with a complex extrasphincteric anal fistula who was treated successfully with fibrin glue application. We further, discuss tips and tricks when applying fibrin glue as plugging material in complex anal fistulas. Case presentation A sixty-one-year-old HIV-positive male referred to us for warts and extrasphincteric fistula. Because of the patients' immunological status, we opted against surgery and recommended fibrin glue plugging. The patient was discharged the same day. A follow-up examination was performed 5 days after the initial fibrin glue application showing that the fistula canal was obstructed. Three months and a year post-intervention the fistula tract remains closed. Conclusion The best treatment for a disease gives at least the same result with the other treatments with minimised risk for the life of the patient and minimal application effort. Conservative closure of fistula with fibrin plugging is simple, safe and with less morbidity than surgery. Our patient was successfully treated without endangering his life despite his precarious medical state. Not everybody believes in the effectiveness of fibrin glue application, however we consider this solution in cases of complex fistulas at least as primary procedure in special populations such as the immunosupressed.

  13. Bio-Inspired Optimal Control Framework to Generate Walking Motions for the Humanoid Robot iCub Using Whole Body Models

    Directory of Open Access Journals (Sweden)

    Yue Hu

    2018-02-01

    Full Text Available Bipedal locomotion remains one of the major open challenges of humanoid robotics. The common approaches are based on simple reduced model dynamics to generate walking trajectories, often neglecting the whole-body dynamics of the robots. As motions in nature are often considered as optimal with respect to certain criteria, in this work, we present an optimal control-based approach that allows us to generate optimized walking motions using a precise whole-body dynamic model of the robot, in contrast with the common approaches. The optimal control problem is formulated to minimize a set of desired objective functions with respect to physical constraints of the robot and contact constraints of the walking phases; the problem is then solved with a direct multiple shooting method. We apply the formulation with combinations of different objective criteria to the model of a reduced version of the iCub humanoid robot of 15 internal DOF. The obtained trajectories are executed on the real robot, and we carry out a discussion on the differences between the outcomes of this approach with the classic approaches.

  14. Encephalopathy and Neuropathy due to Glue, Paint Thinner, and Gasoline Sniffing in Trinidad and Tobago-MRI Findings

    Directory of Open Access Journals (Sweden)

    Kanterpersad Ramcharan

    2014-01-01

    Full Text Available A 29-year-old male petrol station pump attendant was admitted with ataxia and clinical evidence of a sensorimotor polyneuropathy which developed over the preceding 3 months. He had cognitive dysfunction, hearing loss, and cerebellar clinical abnormalities that came on slowly over the three years. He had a fifteen-year history of sniffing mostly glue, occasionally paint thinners, and, in the recent two years, gasoline. Magnetic resonance brain imaging showed abnormalities of the cerebral cortex, cerebral white matter, corpus callosum, hippocampus, brainstem and cerebellar atrophy, hypointensities of basal ganglia, red nuclei, and substantia nigra as previously described in toluene sniffing. Abstinence for six months led to partial clinical improvement. Clinicians need to be aware of this preventable entity which has peculiar radiological findings which are being increasingly accepted as typical.

  15. Fabrication of ceramic oxide-coated SWNT composites by sol-gel process with a polymer glue

    Science.gov (United States)

    Zhang, Cheng; Gao, Lei; Chen, Yongming

    2011-09-01

    The functional copolymer bearing alkoxysilyl and pyrene groups, poly[3-(triethoxysilyl)propyl methacrylate]- co-[(1-pyrene-methyl) methacrylate] (TEPM13- co-PyMMA3), was synthesized via atom transfer radical polymerization. Attributing the π-π interaction of pyrene units with the walls of single-walled carbon nanotubes (SWNTs), this polymer could disperse and exfoliate SWNTs in different solvents through physical interaction as demonstrated by TEM, UV/Vis absorption, and FT-IR analysis. The alkoxysilyl groups functionalized SWNTs were reacted with different inorganic precursors via sol-gel reaction, and, as a results, silica, titania, and alumina were coated onto the surface of SWNTs, respectively via copolymers as a molecular glue. The nanocomposites of ceramic oxides/SWNTs were characterized by SEM analysis. Dependent upon the feed, the thickness of inorganic coating can be tuned easily. This study supplies a facile and general way to coat SWNTs with ceramic oxides without deteriorating the properties of pristine SWNTs.

  16. Nd:YAG laser double wavelength ablation of pollution encrustation on marble and bonding glues on duplicated painting canvas

    Science.gov (United States)

    Batishche, Sergei; Englezis, Apostolis; Gorovets, Tatiana; Kouzmouk, Andrei; Pilipenka, Uladzimir; Pouli, Paraskevi; Tatur, Hennady; Totou, Garyfallia; Ukhau, Viktar

    2005-07-01

    In the present study, a newly developed one-beam IR-UV laser cleaning system is presented. This system may be used for different applications in diverse fields, such as outdoors stonework conservation and canvas paintings restoration. The simultaneous use of the fundamental radiation of a Q-switched Nd:YAG laser at 1064 nm and its third harmonic at 355 nm was found appropriate to clean pollution crusts, while ensuring that no discoloration ("yellowing") would occur. The optimum ratio of UV to IR wavelengths in the final cleaning beam was investigated. In parallel, the same system was tested in diverse applications, such as the removal of bonding glues from duplicated canvases. The optimum laser parameters were investigated both on technical samples as well as on original paintings.

  17. Preparation and characterization of LTA-type zeolite framework dispersed ruthenium nanoparticles and their catalytic application in the hydrolytic dehydrogenation of ammonia–borane for efficient hydrogen generation

    International Nuclear Information System (INIS)

    Zahmakiran, Mehmet

    2012-01-01

    Highlights: ► Ru(0)NPs-ZK-4 were prepared and characterized by advanced analytical techniques. ► They achieve the hydrolysis of ammonia-borane with TOF = 5410 h −1 and TTO = 36700. ► They maintain 85% of their activity even at the fifth catalytic run. - Abstract: The safe and efficient hydrogen storage and production are major obstacles to use hydrogen as an energy carrier. Therefore, significant efforts have been focused on the development of new materials for the chemical hydrogen storage and production. Of particular importance, ammonia–borane (NH 3 BH 3 ) is emerging as one of the most promising solid hydrogen carrier due to its high gravimetric hydrogen storage capacity (19.6 wt.%) and low molecular weight (30.8 g/mol). ammonia–borane can release hydrogen gas upon catalytic hydrolysis under mild conditions. Herein, the discovery of a new catalytic material, ruthenium nanoparticles stabilized by ZK-4 zeolite framework, for this important reaction has been reported. This new catalyst system was prepared by borohydride reduction of ruthenium(III)-exchanged ZK-4 zeolite in water at room temperature. The characterization of the resulting material by advanced analytical tools shows the formation of ZK-4 zeolite dispersed ruthenium nanoparticles (2.9 ± 0.9 nm). The catalytic performance of the resulting supported ruthenium nanoparticles depending on activity, lifetime and reusability was demonstrated in the hydrolytic dehydrogenation of ammonia–borane. They were found to be highly active (initial TOF = 5410 h −1 ), long-lived (TTO = 36,700) and reusable catalyst (retaining of >85% of initial activity in the 5th reuse) in this important catalytic reaction at room temperature under air.

  18. A new platelet cryoprecipitate glue promoting bone formation after ectopic mesenchymal stromal cell-loaded biomaterial implantation in nude mice.

    Science.gov (United States)

    Trouillas, Marina; Prat, Marie; Doucet, Christelle; Ernou, Isabelle; Laplace-Builhé, Corinne; Blancard, Patrick Saint; Holy, Xavier; Lataillade, Jean-Jacques

    2013-01-04

    This study investigated the promising effect of a new Platelet Glue obtained from Cryoprecipitation of Apheresis Platelet products (PGCAP) used in combination with Mesenchymal Stromal Cells (MSC) loaded on ceramic biomaterials to provide novel strategies enhancing bone repair. PGCAP growth factor content was analyzed by ELISA and compared to other platelet and plasma-derived products. MSC loaded on biomaterials (65% hydroxyapatite/35% beta-TCP or 100% beta-TCP) were embedded in PGCAP and grown in presence or not of osteogenic induction medium for 21 days. Biomaterials were then implanted subcutaneously in immunodeficient mice for 28 days. Effect of PGCAP on MSC was evaluated in vitro by proliferation and osteoblastic gene expression analysis and in vivo by histology and immunohistochemistry. We showed that PGCAP, compared to other platelet-derived products, allowed concentrating large amount of growth factors and cytokines which promoted MSC and osteoprogenitor proliferation. Next, we found that PGCAP improves the proliferation of MSC and osteogenic-induced MSC. Furthermore, we demonstrated that PGCAP up-regulates the mRNA expression of osteogenic markers (Collagen type I, Osteonectin, Osteopontin and Runx2). In vivo, type I collagen expressed in ectopic bone-like tissue was highly enhanced in biomaterials embedded in PGCAP in the absence of osteogenic pre-induction. Better results were obtained with 65% hydroxyapatite/35% beta-TCP biomaterials as compared to 100% beta-TCP. We have demonstrated that PGCAP is able to enhance in vitro MSC proliferation, osteoblastic differentiation and in vivo bone formation in the absence of osteogenic pre-induction. This clinically adaptable platelet glue could be of interest for improving bone repair.

  19. A surgical intervention for the body politic: Generation Squeeze applies the Advocacy Coalition Framework to social determinants of health knowledge translation.

    Science.gov (United States)

    Kershaw, Paul; Swanson, Eric; Stucchi, Andrea

    2017-06-16

    The World Health Organization Commission on the Social Determinants of Health (SDoH) observes that building political will is central to all its recommendations, because governments respond to those who organize and show up. Since younger Canadians are less likely to vote or to organize in between elections, they are less effective at building political will than their older counterparts. This results in an age gap between SDoH research and government budget priorities. Whereas Global AgeWatch ranks Canada among the top countries for aging, UNICEF ranks Canada among the least generous OECD (Organisation for Economic Co-operation and Development) countries for the generations raising young children. A surgical intervention into the body politic. Guided by the "health political science" literature, the intervention builds a non-profit coalition to perform science-based, non-partisan democratic engagement to increase incentives for policy-makers to translate SDoH research about younger generations into government budget investments. All four national parties integrated policy recommendations from the intervention into their 2015 election platforms. Three referred to, or consulted with, the intervention during the election. The intervention coincided with all parties committing to the single largest annual increase in spending on families with children in over a decade. Since many population-level decisions are made in political venues, the concept of population health interventions should be broadened to include activities designed to mobilize SDoH science in the world of politics. Such interventions must engage with the power dynamics, values, interests and institutional factors that mediate the path by which science shapes government budgets.

  20. Ni-Pt nanoparticles growing on metal organic frameworks (MIL-96) with enhanced catalytic activity for hydrogen generation from hydrazine at room temperature.

    Science.gov (United States)

    Wen, Lan; Du, Xiaoqiong; Su, Jun; Luo, Wei; Cai, Ping; Cheng, Gongzhen

    2015-04-07

    Well-dispersed bimetallic Ni-Pt nanoparticles (NPs) with different compositions have been successfully grown on the MIL-96 by a simple liquid impregnation method using NaBH4 as the reducing agent. Powder X-ray diffraction, transmission electron microscopy, energy-dispersive X-ray spectroscopy, N2 adsorption-desorption, and inductively coupled plasma-atomic emission spectroscopy measurements were employed to characterize the NiPt/MIL-96. Catalytic activity of NiPt/MIL-96 catalysts was tested in the hydrogen generation from the aqueous alkaline solution of hydrazine at room temperature. These catalysts are composition dependent on their catalytic activity, while Ni64Pt36/MIL-96 exhibits the highest catalytic activity among all the catalysts tested, with a turnover frequency value of 114.3 h(-1) and 100% hydrogen selectivity. This excellent catalytic performance might be due to the synergistic effect of the MIL-96 support and NiPt NPs, while NiPt NPs supported on other conventional supports, such as SiO2, carbon black, γ-Al2O3, poly(N-vinyl-2-pyrrolidone) (PVP), and the physical mixture of NiPt and MIL-96, all of them exhibit inferior catalytic activity compared to that of NiPt/MIL-96.

  1. Information Warfare: using the viable system model as a framework to attack organisations

    Directory of Open Access Journals (Sweden)

    Bill Hutchinson

    2002-05-01

    Full Text Available Information is the glue in any organization. It is needed for policy, decision-making, control, and co-ordination. If an organisation's information systems are disrupted or destroyed, then damage to the whole inevitably follows. This paper uses a proven systemic, analytic framework the Viable System Model (VSM - in a functionalist mode, to analyse the vulnerabilities of an organisation's information resources to this form of aggression. It examines the tactics available, and where they can be used to effectively attack an organisation.

  2. Management of a complicated pulmonary fistula caused by lung cancer using a fibrin glue-soaked polyglycolic acid sheet covered with an intercostal muscle flap.

    Science.gov (United States)

    Maniwa, Tomohiro; Kaneda, Hiroyuki; Saito, Yukihito

    2009-06-01

    Pulmonary fistulas caused by tumours are very fragile and difficult to suture directly. It is impossible to close pulmonary fistulas with tissue sealants when massive air leakage occurs in the low pressure of the respiratory tract. A 73-year-old man with a pneumothorax caused by lung cancer had suffered a persistent massive air leakage for more than one month. We used a fibrin glue-soaked polyglycolic acid (PGA) sheet for sealing the complicated fistula. In addition, the visceral pleura of the fistula was wrapped with the pedicle of an intercostal muscle (ICM) flap to prevent massive air leakage. The pneumothorax did not reappear after surgery. Thus, a fibrin glue-soaked PGA sheet covered with an ICM flap was effective for sealing an intractable air-leaking fistula caused by lung cancer.

  3. Autologous plasma rich in growth factors in the prevention of severe bleeding after teeth extractions in patients with bleeding disorders: a controlled comparison with fibrin glue

    Science.gov (United States)

    Cocero, Nadia; Pucci, Fabrizio; Messina, Maria; Pollio, Berardino; Mozzati, Marco; Bergamasco, Laura

    2015-01-01

    Background Dental extractions in haemophiliacs may cause secondary bleeding, requiring repeated surgical and haematological interventions. As a local haemostatic, fibrin glue has recognised efficacy but, as a plasma-derived product, it carries the risk of viral infections. We, therefore, compared fibrin glue with an autologous haemostatic, plasma rich in growth factors (PRGF), in a controlled trial. Material and methods One hundred and twenty patients with different blood disorders were randomised into two cohorts to undergo dental extraction procedures without hospitalisation. Prior to the extractions, patients underwent systemic haematological treatment. Complications were defined as secondary bleeding after the 7-day follow-up period or protracting after the repair procedure. Results There were 106 extractions (7 retained 3rd molars) in the group managed with fibrin glue: secondary bleeding affected 3/60 patients (5%) on the third day after extraction and necessitated additional surgery and systemic treatment (in one case the procedure had to be repeated on the 7th day). In the PRGF arm there were 98 extractions (23 retained 3rd molars): secondary bleeding affected two patients (3.3%) on the first day after extraction and was arrested with surgery without systemic treatment. Four out of the five secondary bleeds occurred in patients with haemophilia A. Concomitant diabetes or liver disease significantly increased the bleeding risk. Discussion The bleeding rates in the study and control arm prove that PRGF works as well as fibrin glue as a local haemostatic. Further assets are that PRGF has autologous origin, does not require additional systemic treatment in post-extraction repair surgery, is associated with an earlier onset of neo-angiogenesis and, overall, can reduce patients’ distress and costs to the health system. PMID:25369587

  4. [Research of repairing rabbit knee joint cartilage defect by compound material of fibrin glue and decalcified bone matrix (DBM) and chondrocytes].

    Science.gov (United States)

    He, Jie; Yang, Xiang; Yue, Peng-ju; Wang, Guan-yu; Guo, Ting; Zhao, Jian-ning

    2009-07-01

    To investigate the feasibility and effectivity of using compound material of fibrin glue and DBM as scaffolds for cartilage tissue engineering. Chondrocytes isolated from articular cartilage were seeded into prepared scaffolds, after incubation for 4 weeks in vitro. Chondrocytes and fibrin glue and DBM constructs were implanted in the joint cave of rabbit. The specimens were excised at the 4th, 8th, 12th week, examined grossly analyzed by haematoxylin cosine, toluidine blues staining and type II collagen immunohistochemistry reaction. Wakitani score was counted to evaluate the repairing effect. Grossly analysis showed some ivory tissue filled the caves after 4 weeks and the caves were full filled with smooth surface after 12 weeks. The microscope showed a good deal of chondrocytes appeared after 8 weeks and more type II collagen than 4 weeks. Twelve weeks later, cartilage lacuna could be observed. The cells arrangement and the amount of type II collagen both showed the same as the natural one. Complicated material of fibrin glue and DBM as scaffolds can be used as scaffolds for cartilage tissue engineering.

  5. Geometry effect on the behaviour of single and glue-laminated glass fibre reinforced polymer composite sandwich beams loaded in four-point bending

    International Nuclear Information System (INIS)

    Awad, Ziad K.; Aravinthan, Thiru; Manalo, Allan

    2012-01-01

    Highlights: ► Investigated the behaviour of single and glue-laminated GFRP sandwich beam. ► Effect of shear span to depth was a key factor affecting the overall behaviour. ► Comparison with prediction models gave reasonable results in specific regions. ► A failure map was developed to identify the shear and flexural failures of panels. -- Abstract: The research investigated the behaviour of single and glue laminated glass fibre reinforced polymer (GFRP) composite sandwich beams considering different spans and beam cross sections. The composite sandwich beams with different thicknesses (1, 2, 3, 4, and 5 sandwich layers) have been tested in four-point static flexural test with different shear span to depth ratio (a/d). The a/d ratios showed a direct effect on the flexural and shear behaviour. The capacity of the beam decreased with increasing a/d. Various failure modes were observed including core crushing, core shear, and top skin compression failure. The failure mode map developed based on the experimental finding and analytical prediction indicated that the failure mode is affected by the a/d with the number of glue laminated panels.

  6. Next-Generation Web Frameworks in Python

    CERN Document Server

    Daly, Liza

    2007-01-01

    With its flexibility, readability, and maturecode libraries, Python is a naturalchoice for developing agile and maintainableweb applications. Severalframeworks have emerged in the last fewyears that share ideas with Ruby on Railsand leverage the expressive nature of Python.This Short Cut will tell you whatyou need to know about the hottest fullstackframeworks: Django, Pylons, andTurboGears. Their philosophies, relativestrengths, and development status aredescribed in detail. What you won't find out is, "Which oneshould I use?" The short answer is thatall of them can be used to build web appl

  7. Automation Framework for Flight Dynamics Products Generation

    Science.gov (United States)

    Wiegand, Robert E.; Esposito, Timothy C.; Watson, John S.; Jun, Linda; Shoan, Wendy; Matusow, Carla

    2010-01-01

    XFDS provides an easily adaptable automation platform. To date it has been used to support flight dynamics operations. It coordinates the execution of other applications such as Satellite TookKit, FreeFlyer, MATLAB, and Perl code. It provides a mechanism for passing messages among a collection of XFDS processes, and allows sending and receiving of GMSEC messages. A unified and consistent graphical user interface (GUI) is used for the various tools. Its automation configuration is stored in text files, and can be edited either directly or using the GUI.

  8. A Framework for Generating Adaptable Hypermedia Documents

    NARCIS (Netherlands)

    L. Rutledge (Lloyd); J.R. van Ossenbruggen (Jacco); L. Hardman (Lynda); D.C.A. Bulterman (Dick)

    1997-01-01

    textabstractBeing able to author a hypermedia document once for presentation under a wide variety of potential circumstances requires that it be stored in a manner that is adaptable to these circumstances. Since the nature of these circumstances is not always known at authoring time, specifying how

  9. Framework Programmable Platform for the Advanced Software Development Workstation: Preliminary system design document

    Science.gov (United States)

    Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Ackley, Keith A.; Crump, John W., IV; Henderson, Richard; Futrell, Michael T.

    1991-01-01

    The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software environment. Guided by the model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated. The focus here is on the design of components that make up the FPP. These components serve as supporting systems for the Integration Mechanism and the Framework Processor and provide the 'glue' that ties the FPP together. Also discussed are the components that allow the platform to operate in a distributed, heterogeneous environment and to manage the development and evolution of software system artifacts.

  10. Fabrication of ceramic oxide-coated SWNT composites by sol–gel process with a polymer glue

    International Nuclear Information System (INIS)

    Zhang Cheng; Gao Lei; Chen Yongming

    2011-01-01

    The functional copolymer bearing alkoxysilyl and pyrene groups, poly[3-(triethoxysilyl)propyl methacrylate]-co-[(1-pyrene-methyl) methacrylate] (TEPM 13 -co-PyMMA 3 ), was synthesized via atom transfer radical polymerization. Attributing the π–π interaction of pyrene units with the walls of single-walled carbon nanotubes (SWNTs), this polymer could disperse and exfoliate SWNTs in different solvents through physical interaction as demonstrated by TEM, UV/Vis absorption, and FT-IR analysis. The alkoxysilyl groups functionalized SWNTs were reacted with different inorganic precursors via sol–gel reaction, and, as a results, silica, titania, and alumina were coated onto the surface of SWNTs, respectively via copolymers as a molecular glue. The nanocomposites of ceramic oxides/SWNTs were characterized by SEM analysis. Dependent upon the feed, the thickness of inorganic coating can be tuned easily. This study supplies a facile and general way to coat SWNTs with ceramic oxides without deteriorating the properties of pristine SWNTs.

  11. EFFECTS OF PRESS PRESSURE ON GLUE LINE THICKNESS AND PROPERTIES OF LAMINATED VENEER LUMBER GLUED WITH MELAMINE UREA FORMALDEHYDE ADHESIVE

    Directory of Open Access Journals (Sweden)

    Ramazan Kurt,

    2012-07-01

    Full Text Available Laminated veneer lumbers (LVLs were manufactured from half-round sliced I-214 hybrid poplar clone veneers with MUF adhesives using press pressures ranging from 2.5 to 15 kg cm-2. The results showed that the press pressures affected the glue line thickness (GLT and the physical and mechanical properties of the LVLs. Higher specific gravity (SG and mechanical properties, but lower GLT were developed as a result of using higher press pressures. The optimum press pressure was found to be 10 kg cm-2 in relation to GLT, SG, and mechanical properties. Significant linear correlations were found between GLT and mechanical properties. GLT can be used to determine the quality of wood bonding and may become a valuable tool for this purpose. Reliable data on the optimum GLT and press pressures can be used to design safe wood bonding applications in all aspects of wood based composites, as well as wood constructions when appropriate techniques are adopted to measure the GLT.

  12. Efficacy of multifunnel traps for capturing emerald ash borer (Coleoptera: Buprestidae): effect of color, glue, and other trap coatings.

    Science.gov (United States)

    Francese, Joseph A; Fraser, Ivich; Lance, David R; Mastro, Victor C

    2011-06-01

    Tens of thousands of adhesive-coated purple prism traps are deployed annually in the United States to survey for the invasive emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae). A reusable, more user-friendly trap is desired by program managers, surveyors, and researchers. Field assays were conducted in southeastern Michigan to ascertain the feasibility of using nonsticky traps as survey and detection tools for emerald ash borer. Three nonsticky trap designs, including multifunnel (Lindgren), modified intercept panel, and drainpipe (all painted purple) were compared with the standard purple prism trap; no statistical differences in capture of emerald ash borer adults were detected between the multifunnel design and the prism. In subsequent color comparison assays, both green- and purple-painted multifunnel traps (and later, plastic versions of these colors) performed as well or better than the prism traps. Multifunnel traps coated with spray-on adhesive caught more beetles than untreated traps. The increased catch, however, occurred in the traps' collection cups and not on the trap surface. In a separate assay, there was no significant difference detected between glue-coated traps and Rain-X (normally a glass treatment)-coated traps, but both caught significantly more A. planipennis adults than untreated traps.

  13. Glue protein production can be triggered by steroid hormone signaling independent of the developmental program in Drosophila melanogaster.

    Science.gov (United States)

    Kaieda, Yuya; Masuda, Ryota; Nishida, Ritsuo; Shimell, MaryJane; O'Connor, Michael B; Ono, Hajime

    2017-10-01

    Steroid hormones regulate life stage transitions, allowing animals to appropriately follow a developmental timeline. During insect development, the steroid hormone ecdysone is synthesized and released in a regulated manner by the prothoracic gland (PG) and then hydroxylated to the active molting hormone, 20-hydroxyecdysone (20E), in peripheral tissues. We manipulated ecdysteroid titers, through temporally controlled over-expression of the ecdysteroid-inactivating enzyme, CYP18A1, in the PG using the GeneSwitch-GAL4 system in the fruit fly Drosophila melanogaster. We monitored expression of a 20E-inducible glue protein gene, Salivary gland secretion 3 (Sgs3), using a Sgs3:GFP fusion transgene. In wild type larvae, Sgs3-GFP expression is activated at the midpoint of the third larval instar stage in response to the rising endogenous level of 20E. By first knocking down endogenous 20E levels during larval development and then feeding 20E to these larvae at various stages, we found that Sgs3-GFP expression could be triggered at an inappropriate developmental stage after a certain time lag. This stage-precocious activation of Sgs3 required expression of the Broad-complex, similar to normal Sgs3 developmental regulation, and a small level of nutritional input. We suggest that these studies provide evidence for a tissue-autonomic regulatory system for a metamorphic event independent from the primary 20E driven developmental progression. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Mesh fixation in laparoscopic incisional hernia repair: glue fixation provides attachment strength similar to absorbable tacks but differs substantially in different meshes.

    Science.gov (United States)

    Rieder, Erwin; Stoiber, Martin; Scheikl, Verena; Poglitsch, Marcus; Dal Borgo, Andrea; Prager, Gerhard; Schima, Heinrich

    2011-01-01

    Laparoscopic ventral hernia repair has gained popularity among minimally invasive surgeons. However, mesh fixation remains a matter of discussion. This study was designed to compare noninvasive fibrin-glue attachment with tack fixation of meshes developed primarily for intra-abdominal use. It was hypothesized that particular mesh structures would substantially influence detachment force. For initial evaluation, specimens of laminated polypropylene/polydioxanone meshes were anchored to porcine abdominal walls by either helical titanium tacks or absorbable tacks in vitro. A universal tensile-testing machine was used to measure tangential detachment forces (TF). For subsequent experiments of glue fixation, polypropylene/polydioxanone mesh and 4 additional meshes with diverse particular mesh structure, ie, polyvinylidene fluoride/polypropylene mesh, a titanium-coated polypropylene mesh, a polyester mesh bonded with a resorbable collagen, and a macroporous condensed PTFE mesh were evaluated. TF tests revealed that fibrin-glue attachment was not substantially different from that achieved with absorbable tacks (median TF 7.8 Newton [N], range 1.3 to 15.8 N), but only when certain open porous meshes (polyvinylidene fluoride/polypropylene mesh: median 6.2 N, range 3.4 to 10.3 N; titanium-coated polypropylene mesh: median 5.2 N, range 2.1 to 11.7 N) were used. Meshes coated by an anti-adhesive barrier (polypropylene/polydioxanone mesh: median 3.1 N, range 1.7 to 5.8 N; polyester mesh bonded with a resorbable collagen: median 1.3 N, range 0.5 to 1.9 N), or the condensed PTFE mesh (median 3.1 N, range 2.1 to 7.0 N) provided a significantly lower TF (p < 0.01). Fibrin glue appears to be an appealing noninvasive option for mesh fixation in laparoscopic ventral hernia repair, but only if appropriate meshes are used. Glue can also serve as an adjunct to mechanical fixation to reduce the number of invasive tacks. Copyright © 2010 American College of Surgeons. Published by Elsevier

  15. DEVELOPING WEB MAPPING APPLICATION USING ARCGIS SERVER WEB APPLICATION DEVELOPMEN FRAMEWORK (ADF FOR GEOSPATIAL DATA GENERATED DURING REHABILITATION AND RECONSTRUCTION PROCESS OF POST-TSUNAMI 2004 DISASTER IN ACEH

    Directory of Open Access Journals (Sweden)

    Nizamuddin Nizamuddin

    2014-04-01

    Full Text Available ESRI ArcGIS Server is equipped with ArcGIS Server Web Application Development Framework (ADF and ArcGIS Web Controls integration for Visual Studio.NET. Both the ArcGIS Server Manager for .NET and ArcGIS Web Controls can be easily utilized for developing the ASP.NET based ESRI Web mapping application. In  this study we implemented both tools for developing the ASP.NET based ESRI Web mapping application for geospatial data generated dring rehabilitation and reconstruction process of post-tsunami 2004 disaster in Aceh province. Rehabilitation and reconstruction process has produced a tremendous amount of geospatial data. This method was chosen in this study because in the process of developing  a web mapping application, one can easily and quickly create Mapping Services of huge geospatial data and also develop Web mapping application without writing any code. However, when utilizing Visual Studio.NET 2008, one needs to have some coding ability.

  16. Evaluation Framework for Search Instruments

    International Nuclear Information System (INIS)

    Warren, Glen A.; Smith, Leon E.; Cooper, Matt W.; Kaye, William R.

    2005-01-01

    A framework for quantitatively evaluating current and proposed gamma-ray search instrument designs has been developed. The framework is designed to generate a large library of ''virtual neighborhoods'' that can be used to test and evaluate nearly any gamma-ray sensor type. Calculating nuisance-source emissions and combining various sources to create a large number of random virtual scenes places a significant computational burden on the development of the framework. To reduce this burden, a number of radiation transport simplifications have been made which maintain the essential physics ingredients for the quantitative assessment of search instruments while significantly reducing computational times. The various components of the framework, from the simulation and benchmarking of nuisance source emissions to the computational engine for generating the gigabytes of simulated search scenes, are discussed

  17. The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

    Directory of Open Access Journals (Sweden)

    Dong J

    2013-03-01

    Full Text Available Jingjing Dong,1,* Geng Cui,2,* Long Bi,1,* Jie Li,3 Wei Lei11Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Institute of Orthopedics, General Hospital of PLA, Beijing, People’s Republic of China; 3Institute of Gynecology and Obstetrics, General Hospital of PLA, Beijing, People’s Republic of China*These authors contributed equally to this workAbstract: In order to improve the mechanical and biological properties of calcium phosphate cement (CPC, nanometer-biomaterial for bone reconstruction in the rabbit femoral defect model, fibrin glue (FG, the natural product, purified from the blood was introduced at three different ratios. The CPC powder and the FG solution were mixed, respectively, at the powder/liquid (P/L ratios (g/mL of 1:1, 3:1, and 5:1 (g/mL, and pure CPC was used as a control. After being implanted into the femoral defect in rabbit, the healing process was evaluated by micro-computed tomography scan, biomechanical testing, and histological examination. By micro-computed tomography analysis, the P/L ratio of 1:1 (g/mL group indicated the largest quantity of new bone formation at 4 weeks, 8 weeks, and 12 weeks after implantation, respectively. Bone volume per trabecular volume of the 1:1 group was highest in the four groups, which was 1.45% ± 0.42%, 7.35% ± 1.45%, and 29.10% ± 1.67% at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the biomechanical tests, the compressive strength and the elastic modulus of the three CPC–FG groups were much higher than those of the pure CPC group at the determined time point (P < 0.05. The histological evaluation also showed the best osseointegration in the 1:1 group at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the 1:1 group, the bone grew into the pore of the cement in the laminar arrangement and connected with the cement tightly at the 12th week after the operation

  18. Composition of fibrin glues significantly influences axial vascularization and degradation in isolation chamber model.

    Science.gov (United States)

    Arkudas, Andreas; Pryymachuk, Galyna; Hoereth, Tobias; Beier, Justus P; Polykandriotis, Elias; Bleiziffer, Oliver; Gulle, Heinz; Horch, Raymund E; Kneser, Ulrich

    2012-07-01

    In this study, different fibrin sealants with varying concentrations of the fibrin components were evaluated in terms of matrix degradation and vascularization in the arteriovenous loop (AVL) model of the rat. An AVL was placed in a Teflon isolation chamber filled with 500 μl fibrin gel. The matrix was composed of commercially available fibrin gels, namely Beriplast (Behring GmbH, Marburg, Germany) (group A), Evicel (Omrix Biopharmaceuticals S.A., Somerville, New Jersey, USA) (group B), Tisseel VH S/D (Baxter, Vienna, Austria) with a thrombin concentration of 4 IU/ml and a fibrinogen concentration of 80 mg/ml [Tisseel S F80 (Baxter), group C] and with an fibrinogen concentration of 20 mg/ml [Tisseel S F20 (Baxter), group D]. After 2 and 4 weeks, five constructs per group and time point were investigated using micro-computed tomography, and histological and morphometrical analysis techniques. The aprotinin, factor XIII and thrombin concentration did not affect the degree of clot degradation. An inverse relationship was found between fibrin matrix degradation and sprouting of blood vessels. By reducing the fibrinogen concentration in group D, a significantly decreased construct weight and an increased generation of vascularized connective tissue were detected. There was an inverse relationship between matrix degradation and vascularization detectable. Fibrinogen as the major matrix component showed a significant impact on the matrix properties. Alteration of fibrin gel properties might optimize formation of blood vessels.

  19. Activating "Invisible" Glue: Using Electron Beam for Enhancement of Interfacial Properties of Graphene-Metal Contact.

    Science.gov (United States)

    Kim, Songkil; Russell, Michael; Kulkarni, Dhaval D; Henry, Mathias; Kim, Steve; Naik, Rajesh R; Voevodin, Andrey A; Jang, Seung Soon; Tsukruk, Vladimir V; Fedorov, Andrei G

    2016-01-26

    Interfacial contact of two-dimensional graphene with three-dimensional metal electrodes is crucial to engineering high-performance graphene-based nanodevices with superior performance. Here, we report on the development of a rapid "nanowelding" method for enhancing properties of interface to graphene buried under metal electrodes using a focused electron beam induced deposition (FEBID). High energy electron irradiation activates two-dimensional graphene structure by generation of structural defects at the interface to metal contacts with subsequent strong bonding via FEBID of an atomically thin graphitic interlayer formed by low energy secondary electron-assisted dissociation of entrapped hydrocarbon contaminants. Comprehensive investigation is conducted to demonstrate formation of the FEBID graphitic interlayer and its impact on contact properties of graphene devices achieved via strong electromechanical coupling at graphene-metal interfaces. Reduction of the device electrical resistance by ∼50% at a Dirac point and by ∼30% at the gate voltage far from the Dirac point is obtained with concurrent improvement in thermomechanical reliability of the contact interface. Importantly, the process is rapid and has an excellent insertion potential into a conventional fabrication workflow of graphene-based nanodevices through single-step postprocessing modification of interfacial properties at the buried heterogeneous contact.

  20. A comparative in vitro study of the viability of human keratinocytes grown on irradiated human amnion membrane and fibrin glue scaffolds

    International Nuclear Information System (INIS)

    Dorai, A.A.; Lim, C.K.; Azman, W.S.; Halim, A.S.

    2008-01-01

    Full text: The dried irradiated human amnion membrane has been used as a biological dressing for various clinical conditions. Being another biological membrane its potential as a scaffold to grow human keratinocytes is not known yet. To compare the growth patterns and cell viability of keratinocytes using fibrin glue and air dried amnion membrane as a scaffold. Keratinocytes were obtained from skin samples of six patients undergoing elective surgery. Fibrin glue (Tisseel, Baxter ) was diluted and used to coat the wells. Human dried amnion membrane was obtained and placed into the 24 well plates. Keratinocytes were seeded into the fibrin and amnion scaffold. Cell viability assay (MTT) was performed after 24, 48 and 72 hours. Finally the measurements were done by the Enzyme-Linked Immunosorbent Assay (ELISA) reader at 570 nm. Six patients consented for the study. The cells growing on the amnion scaffold showed a decreasing trend (20.67%, 17.94% and 16.78% respectively for 24, 48 and 72 hours). The cells growing on the fibrin scaffold showed a steady increase in number at 24, 48 and 72 hours (73.03%, 74.12% and 79.66%). The percentage of growth of normal human keratinocytes were significantly greater in the fibrin scaffold group (Mann - Whitney p = 0.002) for 24, 48 and 72 hours. The air dried irradiated human amnion membrane can be used as a scaffold to grow keratinocytes but however the growth pattern does not sustain with time. Fibrin glue supports the growth of human keratinocytes and shows an increasing pattern of growth with time. (Author)

  1. Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

    Science.gov (United States)

    Wadley, Lyn; Trower, Gary; Backwell, Lucinda; d'Errico, Francesco

    2015-01-01

    Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone Age sites of Diepkloof

  2. Portal Vein Embolization Using a Nitinol Plug (Amplatzer Vascular Plug) in Combination with Histoacryl Glue and Iodinized Oil: Adequate Hypertrophy with a Reduced Risk of Nontarget Embolization

    International Nuclear Information System (INIS)

    Bent, Clare L.; Low, Deborah; Matson, Matthew B.; Renfrew, Ian; Fotheringham, Tim

    2009-01-01

    The purpose of this study was to assess whether portal vein embolization (PVE) using a nitinol vascular plug in combination with histoacryl glue and iodinized oil minimizes the risk of nontarget embolization while obtaining good levels of future liver remnant (FLR) hypertrophy. Between November 2005 and August 2008, 16 patients (8 females, 8 males; mean age, 63 ± 3.6 years), each with a small FLR, underwent right ipsilateral transhepatic PVE prior to major hepatectomy. Proximal PVE was initially performed by placement of a nitinol vascular plug, followed by distal embolization using a mixture of histoacryl glue and iodinized oil. Pre- and 6 weeks postprocedural FLR volumes were calculated using computed tomographic imaging. Selection for surgery required an FLR of 0.5% of the patient's body mass. Clinical course and outcome of surgical resection for all patients were recorded. At surgery, the ease of hepatectomy was subjectively assessed in comparison to previous experience following PVE with alternative embolic agents. PVE was successful in all patients. Mean procedure time was 30.4 ± 2.5 min. Mean absolute increase in FLR volume was 68.9% ± 12.0% (p = 0.00005). There was no evidence of nontarget embolization during the procedure or on subsequent imaging. Nine patients proceeded to extended hepatectomy. Six patients demonstrated disease progression. One patient did not achieve sufficient hypertrophy in relation to body mass to undergo hepatic resection. At surgery, the hepatobiliary surgeons observed less periportal inflammation compared to previous experience with alternative embolic agents, facilitating dissection at extended hepatectomy. In conclusion, ipsilateral transhepatic PVE using a single nitinol plug in combination with histoacryl glue and iodinized oil simplifies the procedure, offering short procedural times with minimal risk of nontarget embolization. Excellent levels of FLR hypertrophy are achieved enabling safe extended hepatectomy.

  3. Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namibia. Implications for the Evolution of Hunting Equipment in Prehistory.

    Directory of Open Access Journals (Sweden)

    Lyn Wadley

    Full Text Available Ju/'hoan hunters from Nyae Nyae, near Tsumkwe in Namibia, demonstrate the manufacture of three fixative pastes made from plant extracts, and poison made from grubs and plant extracts. Ammocharis coranica and Terminalia sericea produce simple glue. Ozoroa schinzii latex mixed with carbonized Aristeda adscensionis grass is a compound adhesive. Composite poison is made from Chrysomelid grub viscera mixed with salivary extracts of Acacia mellifera inner bark and the tuber sap of Asparagus exuvialis. In order to document potential variability in the chaîne opératoire, and to eliminate inherent biases associated with unique observations, we studied manufacturing processes in three separate Nyae Nyae villages. Although there are methodological similarities in the Nyae Nyae area, we observed a few differences in contemporary traditions of poison manufacture. For example, some hunters make powder from Asparagus exuvialis tuber sap by boiling, reducing, hardening and grinding it, while others simply use heated sap. The Ju/'hoan hunting kit provides insights for archaeologists, but we must exercise caution when looking for continuity between prehistoric and historical technical systems. Some traditions have been lost to modern hunters, while others are new. We should also expect variability in the Stone Age because of geographically restricted resources. Simple glue, compound adhesive, and poison recipes identified in the Stone Age have no modern equivalents. By about 60,000 years ago at Diepkloof, simple glue was used for hafting tools, but at similarly-aged Sibudu there are recipes that combine red ochre powder with plant and/or animal ingredients. At Border Cave, novel poisons and compound adhesives were used in the Early Later Stone Age. It is possible that the complexity that we record in the manufacture of fixative pastes and poison used by Ju/'hoan hunters represents a hafting system both similar to and different from that observed at the Stone

  4. Generative Contexts

    Science.gov (United States)

    Lyles, Dan Allen

    Educational research has identified how science, technology, engineering, and mathematics (STEM) practice and education have underperforming metrics in racial and gender diversity, despite decades of intervention. These disparities are part of the construction of a culture of science that is alienating to these populations. Recent studies in a social science framework described as "Generative Justice" have suggested that the context of social and scientific practice might be modified to bring about more just and equitable relations among the disenfranchised by circulating the value they and their non-human allies create back to them in unalienated forms. What is not known are the underlying principles of social and material space that makes a system more or less generative. I employ an autoethnographic method at four sites: a high school science class; a farm committed to "Black and Brown liberation"; a summer program geared towards youth environmental mapping; and a summer workshop for Harlem middle school students. My findings suggest that by identifying instances where material affinity, participatory voice, and creative solidarity are mutually reinforcing, it is possible to create educational contexts that generate unalienated value, and circulate it back to the producers themselves. This cycle of generation may help explain how to create systems of justice that strengthen and grow themselves through successive iterations. The problem of lack of diversity in STEM may be addressed not merely by recruiting the best and the brightest from underrepresented populations, but by changing the context of STEM education to provide tools for its own systematic restructuring.

  5. Self generation, small generation, and embedded generation issues

    International Nuclear Information System (INIS)

    2001-01-01

    The New Brunswick Market Design Committee for electric power restructuring has been directed to examine issues regarding cogeneration and small-scale, on-site generation and how they will fit within the framework of the bilateral contract market. The Committee will also have to deal with issues of generation embedded in a distribution system. The Committee has defined cogeneration as the simultaneous production of electricity and useful thermal energy. Self-generation has been defined as small-scale power generation by an end-user, while embedded generation has been defined as a generation facility that is located within a distribution utility but is not directly connected to the transmission system. The Committee has postponed its decision on whether embedded generation will be eligible to participate under the bilateral contract market for electricity. This report discusses general issues such as the physical support of generation, market support of generation, transition issues and policy issues. It also discusses generation support issues such as operating reserves, transmission tariff issues, and distribution tariffs. Market support issues such as transmission access for generation sales were also considered, along with market access for generation sales, and net metering for behind the meter generation. 7 refs., 1 tab

  6. Parameter estimation of a two-horizon soil profile by combining crop canopy and surface soil moisture observations using GLUE

    Science.gov (United States)

    Sreelash, K.; Sekhar, M.; Ruiz, L.; Tomer, S. K.; Guérif, M.; Buis, S.; Durand, P.; Gascuel-Odoux, C.

    2012-08-01

    SummaryEstimation of soil parameters by inverse modeling using observations on either surface soil moisture or crop variables has been successfully attempted in many studies, but difficulties to estimate root zone properties arise when heterogeneous layered soils are considered. The objective of this study was to explore the potential of combining observations on surface soil moisture and crop variables - leaf area index (LAI) and above-ground biomass for estimating soil parameters (water holding capacity and soil depth) in a two-layered soil system using inversion of the crop model STICS. This was performed using GLUE method on a synthetic data set on varying soil types and on a data set from a field experiment carried out in two maize plots in South India. The main results were (i) combination of surface soil moisture and above-ground biomass provided consistently good estimates with small uncertainity of soil properties for the two soil layers, for a wide range of soil paramater values, both in the synthetic and the field experiment, (ii) above-ground biomass was found to give relatively better estimates and lower uncertainty than LAI when combined with surface soil moisture, especially for estimation of soil depth, (iii) surface soil moisture data, either alone or combined with crop variables, provided a very good estimate of the water holding capacity of the upper soil layer with very small uncertainty whereas using the surface soil moisture alone gave very poor estimates of the soil properties of the deeper layer, and (iv) using crop variables alone (else above-ground biomass or LAI) provided reasonable estimates of the deeper layer properties depending on the soil type but provided poor estimates of the first layer properties. The robustness of combining observations of the surface soil moisture and the above-ground biomass for estimating two layer soil properties, which was demonstrated using both synthetic and field experiments in this study, needs now to

  7. ZEND FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Lupasc Adrian

    2013-12-01

    Full Text Available In this paper we present Zend Architecture, which is an open source technology for developing web applications and services, based on object-oriented components, and the Model-View-Controller architectural pattern, also known as MVC, which is the fundament of this architecture. The MVC presentation emphasises its main characteristics, such as facilitating the components reuse by dividing the application into distinct interconnected modules, tasks distribution in the process of developing an application, the MVC life cycle and also the essential features of the components in which it separates the application: model, view, controller. The controller coordinates the models and views and it’s responsible with manipulating the user events through the corresponding actions. The model contains application rules, respectively the scripts that implement the database manipulation. The third component, the view represents the controllers interface with the user or the way it displays the response to the event triggered by the user. Another aspect treated in this paper consists in highlighting the Zend architecture advantages and disadvantages. Among the framework advantages, we can enumerate good code organization, due to its delimitation into three sections, presentation, logic and data access, and dividing the code into components, which facilitates the code reuse and testing. Other advantages are the open-source license and the support for multiple database systems. The main disadvantages are represented by its size and complexity, that makes it hard to understand for a beginner programmer, the resources it needs etc. The last section of the paper presents a comparison between Zend and other PHP architectures, like Symphony, CakePHP and CodeIgniter, which includes their essential features and points out their similarities and differences, based on the unique functions that set them apart from others. The main thing that distinguishes ZF from the

  8. Staple Line Reinforcement During Laparoscopic Sleeve Gastrectomy: Absorbable Monofilament, Barbed Suture, Fibrin Glue, or Nothing? Results of a Prospective Randomized Study.

    Science.gov (United States)

    Carandina, S; Tabbara, M; Bossi, M; Valenti, A; Polliand, C; Genser, L; Barrat, Christophe

    2016-02-01

    Laparoscopic sleeve gastrectomy (LSG) is associated with serious complications, such as staple line (SL) leaks and bleeding. In order to prevent the occurrence of these complications, surgeons have advocated the need to strengthen the staple line. The aim of this randomized controlled study was to compare the efficacy of three different ways of strengthening of the SL in LSG in preventing surgical post-operative complications. Between April 2012 and December 2014, 600 patients (pts) scheduled for LSG were prospectively randomized into groups without SL reinforcement (group A) or with SL reinforcement including fibrin glue coverage (group B), or oversewn SL with imbricating absorbable (Monocryl™; group C) or barbed (V lock®) running suture (group D). Primary endpoints were post-operative leaks, bleeding, and stenosis, while secondary outcomes consisted of the time to perform the staple line reinforcement (SLR) and total operative time. Mean SLR operative time was lower for group B (3.4 ± 1.3 min) compared with that for groups C (26.8 ± 8.5 min) and D (21.1 ± 8.4 min) (p running suture or with fibrin glue, is an unrewarding surgical act with the sole effect of prolonging the operative time.

  9. Synthetic spider silk fibers spun from Pyriform Spidroin 2, a glue silk protein discovered in orb-weaving spider attachment discs.

    Science.gov (United States)

    Geurts, Paul; Zhao, Liang; Hsia, Yang; Gnesa, Eric; Tang, Simon; Jeffery, Felicia; La Mattina, Coby; Franz, Andreas; Larkin, Leah; Vierra, Craig

    2010-12-13

    Spider attachment disc silk fibers are spun into a viscous liquid that rapidly solidifies, gluing dragline silk fibers to substrates for locomotion or web construction. Here we report the identification and artificial spinning of a novel attachment disc glue silk fibroin, Pyriform Spidroin 2 (PySp2), from the golden orb weaver Nephila clavipes . MS studies support PySp2 is a constituent of the pyriform gland that is spun into attachment discs. Analysis of the PySp2 protein architecture reveals sequence divergence relative to the other silk family members, including the cob weaver glue silk fibroin PySp1. PySp2 contains internal block repeats that consist of two subrepeat units: one dominated by Ser, Gln, and Ala and the other Pro-rich. Artificial spinning of recombinant PySp2 truncations shows that the Ser-Gln-Ala-rich subrepeat is sufficient for the assembly of polymeric subunits and subsequent fiber formation. These studies support that both orb- and cob-weaving spiders have evolved highly polar block-repeat sequences with the ability to self-assemble into fibers, suggesting a strategy to allow fiber fabrication in the liquid environment of the attachment discs.

  10. Framework for control system development

    International Nuclear Information System (INIS)

    Cork, C.; Nishimura, Hiroshi

    1992-01-01

    Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

  11. Framework for control system development

    International Nuclear Information System (INIS)

    Cork, C.; Nishimura, Hiroshi.

    1991-11-01

    Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

  12. NATO's Nuclear Glue

    National Research Council Canada - National Science Library

    Horton, Scott T

    2007-01-01

    .... nuclear weapons prepositioned in Europe? This paper reviews the past and current role of US nuclear forces in NATO, considers future nuclear policy options, and discusses potential consequences of those decisions...

  13. A Generational Approach to Understanding Students

    Science.gov (United States)

    Coomes, Michael D.; DeBard, Robert

    2004-01-01

    This chapter establishes the conceptual framework for understanding the Millennial generation by presenting a theoretical model of generational succession that demonstrates the value of studying how the values of one generation interact with and are influenced by others.

  14. Dynamic constitutional frameworks for DNA biomimetic recognition.

    Science.gov (United States)

    Catana, Romina; Barboiu, Mihail; Moleavin, Ioana; Clima, Lilia; Rotaru, Alexandru; Ursu, Elena-Laura; Pinteala, Mariana

    2015-02-07

    Linear and cross-linked dynamic constitutional frameworks generated from reversibly interacting linear PEG/core constituents and cationic sites shed light on the dominant coiling versus linear DNA binding behaviours, closer to the histone DNA binding wrapping mechanism.

  15. Fibrin glue instillation under skin flaps to prevent seroma-related morbidity following breast and axillary surgery.

    Science.gov (United States)

    Sajid, Muhammad S; Hutson, Kristian H; Rapisarda, Ignazio F; Bonomi, Riccardo

    2013-05-31

    Fibrin glue (FG) combines fibrinogen and thrombin, under the presence of factor XIII and calcium chloride, and produces a 'fibrin clot' as would occur through the natural clotting cascade. FG is thought to close over any small vessels including lymphatics that are too small for conventional surgical closure, thereby reducing seroma formation, seroma incidence and related comorbidities. To assess the evidence on the effectiveness of FG in people undergoing breast and axillary surgery and to establish whether FG is an efficient modality to prevent postoperative seroma and seroma-related outcomes. We searched the Cochrane Breast Cancer Group's (CBCG) Specialised Register (9 December 2011), the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 1 2012), MEDLINE (9 December 2011), EMBASE (9 December 2011), LILACS (22 October 2012), SCI-E (22 October 2012), the World Health Organization's International Clinical Trial Registry (9 December 2011) and ClinicalTrials.gov (22 October 2012). Randomised controlled trials (RCTs) comparing the effectiveness of FG in terms of reducing the postoperative seroma incidence and related comorbidities in people undergoing breast and axillary surgery. At least two review authors independently scrutinised search results, selected eligible studies and extracted the data. The pooled analysis of the extracted data was achieved by the statistical analysis on Review Manager software. The quality of studies was assessed using The Cochrane Collaboration's 'Risk of bias' tool. The search of four standard electronic databases yielded 119 potentially relevant studies but only 18 RCTs involving 1252 people were found suitable for statistical analysis. There was significant heterogeneity among trials and the majority of trials were of poor quality. The use of FG under skin flaps following breast and axillary surgery failed to reduce the incidence of postoperative seroma (risk ratio (RR) 1.02; 95% Confidence Interval (CI) 0.90 to 1.16, P

  16. Emotion-driven level generation

    OpenAIRE

    Togelius, Julian; Yannakakis, Georgios N.

    2016-01-01

    This chapter examines the relationship between emotions and level generation. Grounded in the experience-driven procedural content generation framework we focus on levels and introduce a taxonomy of approaches for emotion-driven level generation. We then review four characteristic level generators of our earlier work that exemplify each one of the approaches introduced. We conclude the chapter with our vision on the future of emotion-driven level generation.

  17. Endolymphatic Ethiodized Oil Intranodal Lymphangiography and Cyanoacrylate Glue Embolization for the Treatment of Postoperative Lymphatic Leak After Robot-Assisted Laparoscopic Pelvic Resection.

    Science.gov (United States)

    Hill, Hannah; Srinivasa, Ravi N; Gemmete, Joseph J; Hage, Anthony; Bundy, Jacob; Chick, Jeffrey Forris Beecham

    2018-01-01

    Purpose: To report the approach, technical success, clinical outcomes, complications, and follow-up of ethiodized oil intranodal lymphangiography with cyanoacrylate glue embolization for the treatment of lymphatic leak after robot-assisted laparoscopic pelvic resection. Materials and Methods: Four men with mean age 68.7 ± 14.3 years were treated with ethiodized oil intranodal lymphangiography with cyanoacrylate embolization for postoperative lymphatic leak. Patients underwent either (1) cystoprostatectomy with ileal conduit and bilateral extensive pelvic lymph node dissection for muscle-invasive urothelial carcinoma and presented with postoperative lymphatic ascites ( n  = 2) or (2) prostatectomy with bilateral standard pelvic lymph node dissection for prostate carcinoma and presented with postoperative pelvic lymphoceles ( n  = 2). Intranodal lymphangiography and embolization procedural details, technical success, clinical outcomes, and follow-up were recorded. Results: In four patients, a total of six ethiodized oil intranodal lymphangiograms were performed, two procedures being repeated interventions. Inguinal lymph node catheterization and ethiodized oil lymphangiography was technically effective in all procedures. A mean of 5.2 ± 2.0 mL of ethiodized oil was used for lymphatic opacification. Cyanoacrylate was diluted to 24.2% with ethiodized oil and 0.44 mL of cyanoacrylate was instilled during first time interventions. On repeat procedures, cyanoacrylate was diluted to 51.7%, and 0.52 mL was instilled. The primary clinical success rate was 50% ( n  = 2/4). Clinical success was achieved in all patients after two interventions ( n  = 4; 100%). No complications were reported at mean follow-up of 134.7 ± 79.2 days (range: 59-248 days). Conclusion: Ethiodized oil intranodal lymphangiography with direct cyanoacrylate glue embolization is a minimally invasive treatment option for lymphatic leak after pelvic resection.

  18. Development of the Tagger Microscope & Analysis of Spin Density Matrix Elements in gamma-p -> phi-p for the GlueX Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, Alexander E. [Carnegie Mellon Univ., Pittsburgh, PA (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2017-05-31

    The quark model has been successful in classifying the spectrum of mesons observed since the 1960s, however, it fails to explain some of the measured bound states. Lattice QCD predictions have shown that an excited gluonic field may contribute to the quantum numbers of the bound state and form hybrid mesons, qq-bar-g, where g is a constituent gluon. It is possible for some hybrids to possess quantum numbers forbidden by the quark model and are known as \\smoking gun" hybrids due to their lack of mixing with conventional qq-bar states. The GlueX photoproduction experiment at Jefferson Lab in Newport News, VA is designed to study hybrid mesons and to map their spectrum. A 12 GeV electron beam produces 9 GeV linearly polarized photons via coherent bremsstrahlung in a diamond radiator which are incident on a liquid H2 target. In order to determine the photon energy, the use of a tagging spectrometer which measures the energy of the post-bremsstrahlung electron is required. The tagger microscope is a scintillating fiber detector designed to measure the energy of electrons corresponding to the polarized photons. The main focus of this work is the design and construction of the tagger microscope electronics as well as the calibration of the microscope within the experiment. Additionally, the analysis of the reaction gamma-p -> phi-p, where phi (1020) -> K+K-, is discussed. This analysis provides a high-level calibration for GlueX in regards to understanding the acceptance and sensitivity of the detectors to mesons with strange quark content. By studying the phi with linearly polarized photons, information on the production mechanism can be extracted. The measurement of the phi spin-density matrix elements are shown and compared with past data which are found to be in agreement.

  19. Popularity framework for monitoring user workload

    International Nuclear Information System (INIS)

    Molfetas, Angelos; Dimitrov, Gancho; Lassnig, Mario; Garonne, Vincent; Stewart, Graeme; Barisits, Martin; Beermann, Thomas

    2012-01-01

    This paper describes a monitoring framework for large scale data management systems with frequent data access. This framework allows large data management systems to generate meaningful information from collected tracing data and to be queried on demand for specific user usage patterns in respect to source and destination locations, period intervals, and other searchable parameters. The feasibility of such a system at the petabyte scale is demonstrated by describing the implementation and operational experience of a real world management information system for the ATLAS experiment employing the proposed framework. Our observations suggest that the proposed user monitoring framework is capable of scaling to meet the needs of very large data management systems.

  20. An extended framework for science.

    Science.gov (United States)

    Cazalis, Roland

    2017-12-01

    We may be at the cusp of a next generation framework for science which can be facilitated by understanding current limitations in the context of a divergence of 'scientific' tradition from the Axial Age (800-200 BCE) to the present. A powerful advance may come from fusing certain elements from Western and Eastern traditions, synthesizing the framework with an apt understanding of the divergence. Key traits will include the ethopoetic nature of the scientist with attention to his/her experience of self. The framework will also 'access' knowledge through a state of mind less encumbered with paradoxes, duality, incompatibility and other aporias. Case studies in biology and physics illustrate possibilities. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Third generation coaching

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2014-01-01

    Third generation coaching unfolds a new universe for coaching and coaching psychology in the framework of current social research, new learning theories and discourses about personal leadership. Third generation coaching views coaching in a societal perspective. Coaching has become important...... transformation. Coaching thus facilitates new reflections and perspectives, as well as empowerment and support for self-Bildung processes. Third generation coaching focuses on the coach and the coachee in their narrative collaborative partnership. Unlike first generation coaching, where the goal is to help...

  2. Design and Analysis of Web Application Frameworks

    DEFF Research Database (Denmark)

    Schwarz, Mathias Romme

    -state manipulation vulnerabilities. The hypothesis of this dissertation is that we can design frameworks and static analyses that aid the programmer to avoid such errors. First, we present the JWIG web application framework for writing secure and maintainable web applications. We discuss how this framework solves...... some of the common errors through an API that is designed to be safe by default. Second, we present a novel technique for checking HTML validity for output that is generated by web applications. Through string analysis, we approximate the output of web applications as context-free grammars. We model......Numerous web application frameworks have been developed in recent years. These frameworks enable programmers to reuse common components and to avoid typical pitfalls in web application development. Although such frameworks help the programmer to avoid many common errors, we nd...

  3. Spring Framework 5: Themes & Trends

    CERN Document Server

    CERN. Geneva

    2017-01-01

    Spring Framework 5.0/5.1, scheduled for release in early/late 2017, focuses on several key themes: reactive web applications based on Reactive Streams, comprehensive support for JDK 9 and HTTP/2, as well as the latest API generations in the Enterprise Java ecosystem. This talk presents the overall story in the context of wider industry trends, highlighting Spring’s unique programming model strategy.

  4. Programming Entity Framework

    CERN Document Server

    Lerman, Julia

    2010-01-01

    Get a thorough introduction to ADO.NET Entity Framework 4 -- Microsoft's core framework for modeling and interacting with data in .NET applications. The second edition of this acclaimed guide provides a hands-on tour of the framework latest version in Visual Studio 2010 and .NET Framework 4. Not only will you learn how to use EF4 in a variety of applications, you'll also gain a deep understanding of its architecture and APIs. Written by Julia Lerman, the leading independent authority on the framework, Programming Entity Framework covers it all -- from the Entity Data Model and Object Service

  5. Assessing sustainable remediation frameworks using sustainability principles.

    Science.gov (United States)

    Ridsdale, D Reanne; Noble, Bram F

    2016-12-15

    The remediation industry has grown exponentially in recent decades. International organizations of practitioners and remediation experts have developed several frameworks for integrating sustainability into remediation projects; however, there has been limited attention to how sustainability is approached and operationalized in sustainable remediation frameworks and practices - or whether sustainability plays any meaningful role at all in sustainable remediation. This paper examines how sustainability is represented in remediation frameworks and the guidance provided for practical application. Seven broad sustainability principles and review criteria are proposed and applied to a sample of six international remediation frameworks. Not all review criteria were equally satisfied and none of the frameworks fully met all criteria; however, the best performing frameworks were those identified as sustainability remediation frameworks. Intra-generational equity was addressed by all frameworks. Integrating social, economic and biophysical components beyond triple-bottom-line indicators was explicitly addressed only by the sustainable remediation frameworks. No frameworks provided principle- or rule-based guidance for dealing with trade-offs in sustainability decisions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. GeoFramework: A Modeling Framework for Solid Earth Geophysics

    Science.gov (United States)

    Gurnis, M.; Aivazis, M.; Tromp, J.; Tan, E.; Thoutireddy, P.; Liu, Q.; Choi, E.; Dicaprio, C.; Chen, M.; Simons, M.; Quenette, S.; Appelbe, B.; Aagaard, B.; Williams, C.; Lavier, L.; Moresi, L.; Law, H.

    2003-12-01

    As data sets in geophysics become larger and of greater relevance to other earth science disciplines, and as earth science becomes more interdisciplinary in general, modeling tools are being driven in new directions. There is now a greater need to link modeling codes to one another, link modeling codes to multiple datasets, and to make modeling software available to non modeling specialists. Coupled with rapid progress in computer hardware (including the computational speed afforded by massively parallel computers), progress in numerical algorithms, and the introduction of software frameworks, these lofty goals of merging software in geophysics are now possible. The GeoFramework project, a collaboration between computer scientists and geoscientists, is a response to these needs and opportunities. GeoFramework is based on and extends Pyre, a Python-based modeling framework, recently developed to link solid (Lagrangian) and fluid (Eulerian) models, as well as mesh generators, visualization packages, and databases, with one another for engineering applications. The utility and generality of Pyre as a general purpose framework in science is now being recognized. Besides its use in engineering and geophysics, it is also being used in particle physics and astronomy. Geology and geophysics impose their own unique requirements on software frameworks which are not generally available in existing frameworks and so there is a need for research in this area. One of the special requirements is the way Lagrangian and Eulerian codes will need to be linked in time and space within a plate tectonics context. GeoFramework has grown beyond its initial goal of linking a limited number of exiting codes together. The following codes are now being reengineered within the context of Pyre: Tecton, 3-D FE Visco-elastic code for lithospheric relaxation; CitComS, a code for spherical mantle convection; SpecFEM3D, a SEM code for global and regional seismic waves; eqsim, a FE code for dynamic

  7. Graph Generator Survey

    Energy Technology Data Exchange (ETDEWEB)

    Lothian, Joshua [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Powers, Sarah S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sullivan, Blair D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Baker, Matthew B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schrock, Jonathan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Poole, Stephen W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2013-10-01

    The benchmarking effort within the Extreme Scale Systems Center at Oak Ridge National Laboratory seeks to provide High Performance Computing benchmarks and test suites of interest to the DoD sponsor. The work described in this report is a part of the effort focusing on graph generation. A previously developed benchmark, SystemBurn, allowed the emulation of different application behavior profiles within a single framework. To complement this effort, similar capabilities are desired for graph-centric problems. This report examines existing synthetic graph generator implementations in preparation for further study on the properties of their generated synthetic graphs.

  8. Utilização de adesivo de fibrina em cirurgias oftalmológicas Use of fibrin glue in ocular surgery

    Directory of Open Access Journals (Sweden)

    Melissa Manfroi Dal Pizzol

    2009-06-01

    Full Text Available OBJETIVO: Avaliar as diferentes técnicas cirúrgicas oftalmológicas nas quais se pode utilizar a cola biológica e possíveis complicações relacionadas ao seu uso. MÉTODOS: Estudo de série de casos retrospectivo, não-comparativo. Foram avaliados 161 olhos de pacientes com idade média de 51,8 anos em que foi utilizada cola biológica (Beriplast P® - Aventis Behring, Alemanha para fixação de tecido ou fechamento incisional. RESULTADOS: Foram avaliados 76 pacientes com pterígio, 4 com ceratoconjuntivite límbica superior, 4 com tumor limbar, 21 com conjuntivocálase, 31 com ceratopatia bolhosa, 7 com deficiência límbica, 6 com queimadura alcalina, 2 com Stevens-Johnson, 5 com catarata e 5 com glaucoma. Complicações foram relatas em 28 casos (17,4%. Descolamento do tecido fixado e granuloma foram as complicações mais frequentes. Descolamento ocorreu em 10 casos (5,6% (7 em transplante de membrana amniótica em ceratopatia bolhosa, 2 em transplante de conjuntiva autólogo após exérese de pterígio, 1 após transplante de limbo autólogo por Stevens-Johnson. Granuloma ocorreu em 9 casos (5,6% (5 em pacientes com queimadura alcalina aguda tratados com transplante de membrana amniótica, 1 em paciente com sequela de queimadura tratado com transplante de limbo autólogo e 3 em pacientes após exérese de pterígio tratados com transplante de conjuntiva autólogo. Todas as complicações ocorreram dentro da primeira semana de pós-operatório. CONCLUSÃO: Embora o presente seja retrospectivo e não-comparativo, podemos observar que a utilização do adesivo de fibrina parece ser segura e efetiva, além de apresentar baixas taxas de complicações nas cirurgias de superfície ocular e de segmento anterior.PURPOSE: To evaluate the use of fibrin glue and its complications in different ophthalmic surgeries. METHODS: A retrospective and non-comparative case series study. 161 eyes were evaluated. The mean age was 51.8 years. Fibrin glue

  9. Protocol Implementation Generator

    DEFF Research Database (Denmark)

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.

    2010-01-01

    Users expect communication systems to guarantee, amongst others, privacy and integrity of their data. These can be ensured by using well-established protocols; the best protocol, however, is useless if not all parties involved in a communication have a correct implementation of the protocol and a...... Generator framework based on the LySatool and a translator from the LySa language into C or Java....... necessary tools. In this paper, we present the Protocol Implementation Generator (PiG), a framework that can be used to add protocol generation to protocol negotiation, or to easily share and implement new protocols throughout a network. PiG enables the sharing, verification, and translation...

  10. House of Generations

    DEFF Research Database (Denmark)

    Geert Jensen, Birgitte

    2017-01-01

    only the benefits of living close to the family. The Aarhus Municipality project "House of Generations" is a vision for creating a framework for relationships across all generations, for meaningful encounters and for rewarding neighbourliness. Three of Aarhus Municipality's magistrate departments...... participate in the project: Health and Care, Children and Youth, and Social Conditions and Employment. A public housing association that provides student dorms also participates in the project. The physical framework will be a building with a total area of approx. 25,000 m², located at Pier 4, at Aarhus......' harbour areas. The building will be a multi-generational house comprising a mixture of flexible public housing units for students, the elderly and residents who require care (elderly disabled people and people with acquired brain injuries). The building will be connected with common areas located in close...

  11. Programming Entity Framework

    CERN Document Server

    Lerman, Julia

    2009-01-01

    Programming Entity Framework is a thorough introduction to Microsoft's new core framework for modeling and interacting with data in .NET applications. This highly-acclaimed book not only gives experienced developers a hands-on tour of the Entity Framework and explains its use in a variety of applications, it also provides a deep understanding of its architecture and APIs -- knowledge that will be extremely valuable as you shift to the Entity Framework version in .NET Framework 4.0 and Visual Studio 2010. From the Entity Data Model (EDM) and Object Services to EntityClient and the Metadata Work

  12. A flexible regulatory framework

    International Nuclear Information System (INIS)

    Silvennoinen, T.

    2000-01-01

    Regulatory reform of the Finnish electricity market meant opening up potentially competitive parts of the electricity sector to competition and eliminating all unnecessary forms of regulation covering generation, wholesale supply, retail supply, and foreign trade in electricity. New types of control and regulatory mechanisms and institutions were set up for those parts of the electricity industry that were excluded from competition, such as network operations. Network activities now have to be licensed, whereas no licence is needed for generation or supply. A new sector-specific regulatory authority was established in 1995 to coincide with the implementation of the Electricity Market Act, known as the Electricity Market Authority. This is responsible for regulating network activities and retail supply to captive customers. The core function of the authority, which employs some 14 people, is to promote the smooth operation of the Finnish electricity market and to oversee the implementation of the Electricity Market Act and its provisions. Its most important duties are linked to overseeing the process by which network companies price their electricity. As price regulation no longer exists, all the companies in the electricity sector set their tariffs independently, even network companies. The job of controlling the pricing of network services is handed by the Electricity Market Authority, following the principles of competition control. Pricing control takes place ex post - after a pricing system has been adopted by a company and concentrates on individual cases and companies. There is no ex ante system of setting or approving prices and tariffs by the regulator. The tariffs and pricing of network services can be evaluated, however, by both the Electricity Market Authority and the Finnish Competition Authority, which have overlapping powers as regards the pricing of network activities. The Finnish regulatory framework can be described as a system of light

  13. Analysis of the η(548) ->π+π-π0 and η'(958) ->π+π- η channels using a 8-9 GeV tagged photon beam for the GlueX Experiment

    Science.gov (United States)

    Beattie, Tegan; Papandreou, Zisis; Stevens, Justin; GlueX Collaboration

    2016-09-01

    The primary goal of the GlueX experiment is to conduct a definitive mapping of states in the light meson sector with an emphasis on searching for exotic hybrid mesons as evidence of gluonic excitations. The experiment, housed in the Hall-D facility at Jefferson Lab following its accelerator upgrade to 12 GeV, is now entering the physics data taking phase. The η(548) and η'(958) mesons are two of the richest unflavoured light mesons readily available at GlueX energies for studying resonances. Many other light mesons have decay channels involving the η mesons with significant branching ratios, and πη / πη' resonances are among the top contenders for possibly-accessible exotic and hybrid resonances which GlueX aims to study. As such, the ability to reconstruct pure η/η' samples and analyze their decays is of utmost importance for understanding future work on more complicated analyses. Preliminary analysis results from commissioning data will be presented. This work was supported by NSERC Grant SAPJ-326516 and Jefferson Science Associates, LLC, who operates Jefferson Lab under U.S. DOE Contract No. DE-AC05-06OR23177.

  14. NEAMS-IPL MOOSE Midyear Framework Activities

    International Nuclear Information System (INIS)

    Permann, Cody; Alger, Brian; Peterson, John; Slaughter, Andrew; Andrš, David; Martineau, Richard

    2017-01-01

    The MOOSE Framework is a modular pluggable framework for building complex simulations. The ability to add new objects with custom syntax is a core capability that makes MOOSE a powerful platform for coupling multiple applications together within a single environment. The creation of a new, more standardized JSON syntax output improves the external interfaces for generating graphical components or for validating input file syntax. The design of this interface and the requirements it satisfies are covered in this short report.

  15. NEAMS-IPL MOOSE Midyear Framework Activities

    Energy Technology Data Exchange (ETDEWEB)

    Permann, Cody [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alger, Brian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Peterson, John [Idaho National Lab. (INL), Idaho Falls, ID (United States); Slaughter, Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States); Andrš, David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Martineau, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-05-09

    The MOOSE Framework is a modular pluggable framework for building complex simulations. The ability to add new objects with custom syntax is a core capability that makes MOOSE a powerful platform for coupling multiple applications together within a single environment. The creation of a new, more standardized JSON syntax output improves the external interfaces for generating graphical components or for validating input file syntax. The design of this interface and the requirements it satisfies are covered in this short report.

  16. An Agent Framework of Tourism Recommender System

    Directory of Open Access Journals (Sweden)

    Jia Zhi Yang

    2016-01-01

    Full Text Available This paper proposes the development of an Agent framework for tourism recommender system. The recommender system can be featured as an online web application which is capable of generating a personalized list of preference attractions for tourists. Traditional technologies of classical recommender system application domains, such as collaborative filtering, content-based filtering and content-based filtering are effectively adopted in the framework. In the framework they are constructed as Agents that can generate recommendations respectively. Recommender Agent can generate recommender information by integrating the recommendations of Content-based Agent, collaborative filtering-based Agent and constraint-based Agent. In order to make the performance more effective, linear combination method of data fusion is applied. User interface is provided by the tourist Agent in form of webpages and mobile app.

  17. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    Models are playing important roles in design and analysis of chemicals based products and the processes that manufacture them. Computer-aided methods and tools have the potential to reduce the number of experiments, which can be expensive and time consuming, and there is a benefit of working...... development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...

  18. Electrically conductive poly-ɛ-caprolactone/polyethylene glycol/multi-wall carbon nanotube nanocomposite scaffolds coated with fibrin glue for myocardial tissue engineering

    Science.gov (United States)

    Mehdikhani, Mehdi; Ghaziof, Sharareh

    2018-01-01

    In this research, poly-ɛ-caprolactone (PCL), polyethylene glycol (PEG), multi-wall carbon nanotubes (MWCNTs), and nanocomposite scaffolds containing 0.5 and 1% (w/w) MWCNTs coated with fibrin glue (FG) were prepared via solvent casting and freeze-drying technique for cardiac tissue engineering. Scanning electron microscopy, transmission electron microscopy, Fourier transform-infrared spectroscopy, and X-ray diffraction were used to characterize the samples. Furthermore, mechanical properties, electrical conductivity, degradation, contact angle, and cytotoxicity of the samples were evaluated. Results showed the uniform distribution of the MWCNTs with some aggregates in the prepared nanocomposite scaffolds. The scaffolds containing 1% (w/w) MWCNTs with and without FG coating illustrated optimum modulus of elasticity, high electrical conductivity, and wettability compared with PCL/PEG and PCL/PEG/0.5%(w/w) MWCNTs' scaffolds. FG coating enhanced electrical conductivity and cell response, and increased wettability of the constructs. The prepared scaffolds were degraded significantly after 60 days of immersion in PBS. Meanwhile, the nanocomposite containing 1% (w/w) MWCNTs with FG coating (S3) showed proper spreading and viability of the myoblasts seeded on it after 1, 4, and 7 days of culture. The scaffold containing 1% (w/w) MWCNTs with FG coating demonstrated optimal properties including acceptable mechanical properties, proper wettability, high electrical conductivity, satisfactory degradation, and excellent myoblasts response to it.

  19. Crystal water as the mol-ecular glue for obtaining different co-crystal ratios: the case of gallic acid tris-caffeine hexa-hydrate.

    Science.gov (United States)

    Vella-Zarb, L; Baisch, U

    2018-04-01

    The crystal structure of the hexa-hydrate co-crystal of gallic acid and caffeine, C 7 H 6 O 5 ·3C 8 H 10 N 4 O 2 ·6H 2 O or GAL3CAF·6H 2 O , is a remarkable example of the importance of hydrate water acting as structural glue to facilitate the crystallization of two components of different stoichiometries and thus to compensate an imbalance of hydrogen-bond donors and acceptors. The water mol-ecules provide the additional hydrogen bonds required to form a crystalline solid. Whereas the majority of hydrogen bonds forming the inter-molecular network between gallic acid and caffeine are formed by crystal water, only one direct classical hydrogen bond between two mol-ecules is formed between the carb-oxy-lic oxygen of gallic acid and the carbonyl oxygen of caffeine with d ( D ⋯ A ) = 2.672 (2) Å. All other hydrogen bonds either involve crystal water or utilize protonated carbon atoms as donors.

  20. Automated double-cone-beam CT fusion technique. Enhanced evaluation of glue distribution in cases of spinal dural arteriovenous fistula (SDAVF) embolisation

    International Nuclear Information System (INIS)

    Farago, Giuseppe; Caldiera, V.; Antozzi, C.; Bellino, A.; Innocenti, A.; Ciceri, E.

    2017-01-01

    Spinal dural arteriovenous fistulas (SDAVFs) are acquired diseases that represent the majority of all arteriovenous spinal shunts, leading to progressive and disabling myelopathy. Treatment is focused on accurately disconnecting the fistula point. We present our experience with the double-cone-beam CT fusion technique successfully applied to evaluate treatment results in a series of SDAVFs. Between November 2011 and December 2015 we performed double-DynaCT acquisition (pre- and post-embolisation) in 12 cases of SDAVF. A successful DynaCT fusion technique was only achieved in the group of patients with pre- and post-treatment images acquired at the same time as the treatment session, under general anaesthesia (4/12). DynaCT performed on different days proved to be inadequate for the automated fusion technique because of changes in the body position (8/12). A pre-treatment flat-panel cone-beam CT with contrast, at the time of diagnostic angiography, can be very helpful to detect the correct level of the fistula and the relationship between the fistula and the surrounding structures. In case of the endovascular approach, additional post-treatment native acquisition merged with the pre-treatment acquisition (double-cone-beam CT fusion technique) permits to immediately evaluate the distribution of the glue cast and to confirm the success of the procedure. (orig.)

  1. Treatment of non-healing sternum wound after open-heart surgery with allogenic platelet-rich plasma and fibrin glue-preliminary outcomes

    Directory of Open Access Journals (Sweden)

    Mohammad Abbasi Tashnizi

    2013-01-01

    Full Text Available Introduction: Non-healing wound in the sternal region after coronary arteries bypass graft surgery is a serious complication. For healing a chronic wound, several novel approaches have been proposed recently such as using bone marrow stem cells, platelets and fibrin glue (PFG; but a non-invasive method is highly desirable in the first approach for treatment. The current study was undertaken to evaluate the effect of the combination of PFG in one treatment. Materials and Methods: We report on the treatment of six patients with life-threatening chronic sternum wounds, which caused septicemia with multi-drug resistant pathogens. The ulcers were extensively debrided initially and were measured and photographed at weekly intervals. The combination of PFG was applied topically on the wound after every 2 days. Results: The wounds were completely closed in five patients and significantly reduced in size in one. There was no evidence of local or systemic complications and any abnormal tissue formation, keloid or hypertrophic scarring. Conclusions: Our study suggests, in the first approach, PFG can be used safely in order to heal a non healing sternum wound following coronary artery bypass surgery.

  2. Automated double-cone-beam CT fusion technique. Enhanced evaluation of glue distribution in cases of spinal dural arteriovenous fistula (SDAVF) embolisation

    Energy Technology Data Exchange (ETDEWEB)

    Farago, Giuseppe [Foundation Neurological Institute ' ' C. Besta' ' , Department of Interventional Neuroradiology, Milan (Italy); Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Interventional Neuroradiology, Milan (Italy); Caldiera, V. [Foundation Neurological Institute ' ' C. Besta' ' , Department of Interventional Neuroradiology, Milan (Italy); Antozzi, C.; Bellino, A. [Foundation Neurological Institute ' ' C. Besta' ' , Department of Neuroimmunology and Neuromuscular Diseases, Milan (Italy); Innocenti, A. [Foundation Neurological Institute ' ' C. Besta' ' , Department of Neuro-Oncology, Milan (Italy); Ciceri, E. [Foundation Neurological Institute ' ' C. Besta' ' , Department of Interventional Neuroradiology, Milan (Italy); Azienda Ospedaliera Universitaria Integrata Borgo Trento, Department of Neuroradiology, Verona (Italy)

    2017-05-15

    Spinal dural arteriovenous fistulas (SDAVFs) are acquired diseases that represent the majority of all arteriovenous spinal shunts, leading to progressive and disabling myelopathy. Treatment is focused on accurately disconnecting the fistula point. We present our experience with the double-cone-beam CT fusion technique successfully applied to evaluate treatment results in a series of SDAVFs. Between November 2011 and December 2015 we performed double-DynaCT acquisition (pre- and post-embolisation) in 12 cases of SDAVF. A successful DynaCT fusion technique was only achieved in the group of patients with pre- and post-treatment images acquired at the same time as the treatment session, under general anaesthesia (4/12). DynaCT performed on different days proved to be inadequate for the automated fusion technique because of changes in the body position (8/12). A pre-treatment flat-panel cone-beam CT with contrast, at the time of diagnostic angiography, can be very helpful to detect the correct level of the fistula and the relationship between the fistula and the surrounding structures. In case of the endovascular approach, additional post-treatment native acquisition merged with the pre-treatment acquisition (double-cone-beam CT fusion technique) permits to immediately evaluate the distribution of the glue cast and to confirm the success of the procedure. (orig.)

  3. A case grafted with polyglycolic acid sheets and fibrin glue for protection after temporary resection of a metastatic cervical skin tumor.

    Science.gov (United States)

    Matsuzuka, Takashi; Suzuki, Masahiro; Ikeda, Masakazu; Sato, Kaoru; Fujimoto, Junko; Hosaka, Rumi; Tanji, Yuko; Soeda, Shu; Murono, Shigeyuki

    2018-04-01

    The aim of this case report was to evaluate the usefulness of a grafting with polyglycolic acid sheet and a fibrin glue spray (PGA sheet grafting) after resection of a cervical skin tumor. A 61-year-old woman presented with left cervical skin tumor resistance to chemo-radiotherapy. She had been undergoing multimodal therapy for ovarian serous papillary adenocarcinoma for the previous six years. Although she had a poor general condition and a cervical skin tumor of 9cm in diameter, which was painful and easy bleeding, had offensive smell, she hoped to return to her job. Under local anesthesia, resection was performed, and PGA sheet grafting were used to shield the skin defect. After resection, she was relieved from pain, and could stay home without daily wound treatment. One and half months after resection, the wound was almost epithelialized. The PGA sheets consist of soft, elastic, nonwoven fabric made of PGA. In recent years, PGA sheet grafting has been widely used in the reconstruction and was chosen to shield the skin defect for this case. PGA sheet grafting after resection of cervical skin tumor can be an acceptable method for palliative care to relieve pain, bleeding, offensive smell, and ugly appearance. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Lime-based restoration paints: characterization and evaluation of formulations using a native species from the Amazon flora and PVA-based glue as additives

    Directory of Open Access Journals (Sweden)

    Mayra Martins Silva

    Full Text Available Abstract Based on historic documents, two lime-based paint formulations were produced in laboratory in order to evaluate their basic characteristics as restoration materials for historic buildings with lime-based components. The paints were made basically with hydrated lime, clay, water and linseed (Linum usitatissimum L. oil, and one formulation had PVA (polyvinyl acetate-based glue as fixative, and the other one, Couma guianensis' latex. Each paint component was characterized by XRD and FTIR, and color and specular gloss measurements were performed on both paints. A preliminary assessment of the paints was conducted using the Pipe Method, the salt crystallization test, visual analysis for dustiness, and analysis of microbiological growth. The results showed that the laboratory-produced paints are theoretically and technologically compatible with lime-based coatings, however, their superficial performance can be improved to achieve greater durability. This study also brings to light local materials from the Amazon region that have great potential to be used and recognized as raw materials for paints and which could also be investigated for other uses.

  5. Frameworks in CS1

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Caspersen, Michael Edelgaard

    2002-01-01

    point for introducing graphical user interface frameworks such as Java Swing and AWT as the students are not overwhelmed by all the details of such frameworks right away but given a conceptual road-map and practical experience that allow them to cope with the complexity.......In this paper we argue that introducing object-oriented frameworks as subject already in the CS1 curriculum is important if we are to train the programmers of tomorrow to become just as much software reusers as software producers. We present a simple, graphical, framework that we have successfully...... used to introduce the principles of object-oriented frameworks to students at the introductory programming level. Our framework, while simple, introduces central abstractions such as inversion of control, event-driven programming, and variability points/hot-spots. This has provided a good starting...

  6. Quality Attribute Techniques Framework

    Science.gov (United States)

    Chiam, Yin Kia; Zhu, Liming; Staples, Mark

    The quality of software is achieved during its development. Development teams use various techniques to investigate, evaluate and control potential quality problems in their systems. These “Quality Attribute Techniques” target specific product qualities such as safety or security. This paper proposes a framework to capture important characteristics of these techniques. The framework is intended to support process tailoring, by facilitating the selection of techniques for inclusion into process models that target specific product qualities. We use risk management as a theory to accommodate techniques for many product qualities and lifecycle phases. Safety techniques have motivated the framework, and safety and performance techniques have been used to evaluate the framework. The evaluation demonstrates the ability of quality risk management to cover the development lifecycle and to accommodate two different product qualities. We identify advantages and limitations of the framework, and discuss future research on the framework.

  7. Generating Units

    Data.gov (United States)

    Department of Homeland Security — Generating Units are any combination of physically connected generators, reactors, boilers, combustion turbines, and other prime movers operated together to produce...

  8. Quantification of traffic generation and its environmental impacts through decisions, frameworks and measures indirectly influencing transportation; Quantifizierung der Verkehrsentstehung und deren Umweltauswirkungen durch Entscheidungen, Regelwerke und Massnahmen mit indirektem Verkehrsbezug

    Energy Technology Data Exchange (ETDEWEB)

    Holz-Rau, C.; Hesse, M.; Geier, S.; Holzhey, A.; Rau, P.; Schreiner, J.; Schenk, E. [Buero fuer Integrierte Planung, Herdecke (Germany); Arndt, W.H.; Flaemig, H.; Rogge, L.; Steinfeld, M. [Institut fuer Oekologische Wirtschaftsforschung (IOEW) gGmbH, Berlin (Germany)

    2000-09-01

    Legislation (e.g. at the Federal or State level) outside the transportation policy sphere may have indirect impacts on traffic structure and generation. Four case studies have been carried out in order to analyse transport related impact chains, to quantify possible transportation impacts and to identify potential strategies for minimising impacts generated by non-transport-specific legislation. One result is a questionnaire designed as a further element of transportation impact assessment. The goal is to quickly evaluate potential impacts and to modify such proposed legislation in order to minimise negative impacts. Interestingly, the quantification of certain transportion impacts, a difficult task, proved not to be essential. (orig.) [German] Von Vorhaben ausserhalb des Verkehrsbereichs (z.B. Bundesgesetze oder Landesrichtlinien) koennen indirekte Effekte auf die Verkehrsstrukturen ausgehen. Fuer vier Fallbeispiele wurden verkehrsrelevante Wirkungsketten analysiert, die Verkehrseffekte ansatzweise quantifiziert und potentielle Handlungsansaetze fuer eine verkehrssparsamere Modifikation der Vorhaben identifiziert. Es wurde ein Frageschema entwickelt, dessen Anwendung als Fortsetzung einer Verkehrsauswirkungspruefung zur fruehzeitigen Beruecksichtigung von Verkehrseffekten und zur verkehrssparsamen Modifikation von Vorhaben mit indirektem Verkehrsbezug beitragen kann. Eine Quantifizierung der Verkehrseffekte erwies sich dazu in der Regel als entbehrlich. (orig.)

  9. JT Bachman Leadership Framework

    Science.gov (United States)

    2017-07-01

    DAHLGREN DIVISION NAVAL SURFACE WARFARE CENTER Dahlgren, Virginia 22448-5100 NSWCDD/MP-17/300 JT BACHMAN LEADERSHIP FRAMEWORK...REPORT TYPE Miscellaneous Publication 3. DATES COVERED (From - To) 27 Sept 2016 – 08 June 2017 4. TITLE AND SUBTITLE JT BACHMAN LEADERSHIP FRAMEWORK...distribution is unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT This document describes the leadership framework of a civil servant following

  10. Frameworks in CS1

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Caspersen, Michael Edelgaard

    2002-01-01

    In this paper we argue that introducing object-oriented frameworks as subject already in the CS1 curriculum is important if we are to train the programmers of tomorrow to become just as much software reusers as software producers. We present a simple, graphical, framework that we have successfull...... point for introducing graphical user interface frameworks such as Java Swing and AWT as the students are not overwhelmed by all the details of such frameworks right away but given a conceptual road-map and practical experience that allow them to cope with the complexity....

  11. Frameworks in CS1

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Caspersen, Michael Edelgaard

    2002-01-01

    point for introducing graphical user interface frameworks such as Java Swing and AWT as the students are not overwhelmed by all the details of such frameworks right away but given a conceptual road-map and practical experience that allow them to cope with the complexity.......In this paper we argue that introducing object-oriented frameworks as subject already in the CS1 curriculum is important if we are to train the programmers of tomorrow to become just as much software reusers as software producers. We present a simple, graphical, framework that we have successfully...

  12. BOA: Framework for Automated Builds

    CERN Document Server

    Ratnikova, N

    2003-01-01

    Managing large-scale software products is a complex software engineering task. The automation of the software development, release and distribution process is most beneficial in the large collaborations, where the big number of developers, multiple platforms and distributed environment are typical factors. This paper describes Build and Output Analyzer framework and its components that have been developed in CMS to facilitate software maintenance and improve software quality. The system allows to generate, control and analyze various types of automated software builds and tests, such as regular rebuilds of the development code, software integration for releases and installation of the existing versions.

  13. BOA: Framework for automated builds

    International Nuclear Information System (INIS)

    Ratnikova, N.

    2003-01-01

    Managing large-scale software products is a complex software engineering task. The automation of the software development, release and distribution process is most beneficial in the large collaborations, where the big number of developers, multiple platforms and distributed environment are typical factors. This paper describes Build and Output Analyzer framework and its components that have been developed in CMS to facilitate software maintenance and improve software quality. The system allows to generate, control and analyze various types of automated software builds and tests, such as regular rebuilds of the development code, software integration for releases and installation of the existing versions

  14. Regulatory frameworks for decentralised energy

    International Nuclear Information System (INIS)

    Woodman, Bridget; Baker, Philip

    2008-01-01

    This paper considers aspects of the current regulatory frameworks for markets and infrastructure which can inhibit the deployment of decentralised energy. The government has stated that decentralised energy can make a positive contribution to reducing the UK's carbon emissions, but recognises that at the moment the technologies face market and regulatory barriers. If it is to become a viable alternative to centralised generation, energy market design and the regulation of energy infrastructure will have to evolve to ensure that decentralised options are no longer locked out. (author)

  15. Employment and income generation within the framework of the 'Luz para todos' program in the State of Amazonas, Brazil; Geracao de emprego e renda no ambito do programa Luz para Todos no estado do Amazonas

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Rubem Cesar Rodrigues; Moraes, Betsy Eddy Praia; Souza, Cristiane Daliassi Ramos de [Universidade Federal do Amazonas (UFAM), Manaus, AM (Brazil). Centro de Desenvolvimento Energetico Amazonico

    2008-07-01

    The low level of the electric demand to be accomplished in the isolated Amazon communities, associated to the low purchasing power of those populations and the high costs for electrification of these, they impose the implementation of concrete actions of generation of job and income when it intend to assure the universalization of the electric power service in isolated Amazon communities, as ir the case of the program 'Luz para Todos'. The present article shows that is being developed by the committee state manager of the program 'Luz para Todos' in the amazon state, demonstrating that it is possible to assure good results since the effective involvement of several agents is made possible. (author)

  16. Synthesis, characterization, and in vitro evaluation of a radio-metal organic framework composed of in vivo generator {sup 166}Dy/{sup 166}Ho and DOTMP as a novel agent for bone marrow ablation

    Energy Technology Data Exchange (ETDEWEB)

    Vosoghi, Sara; Shirvani-Arani, Simindokht; Bahrami-Samani, Ali; Salek, Nafise; Mirerezaei, Ehsan; Jalilian, Amir Reza [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of)

    2016-07-01

    In this study, the MOF concept contributed to the preparation of a novel, bone-ablating agent composed of Cu(II) using the in vivo generator {sup 166}Dy/{sup 166}Ho and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP). The product was characterized (IR, elemental analysis: CHN, ICM-MS, PIXE, DLS, XRD) and quality-controlled (radio-thin layer chromatography (RTLC)). The stability and in vitro hydroxyapatite binding was checked up to one week at 37 C in human serum. Radio-MOF crystals and colloidal radio-MOF particles were obtained by varying the synthesizing conditions (including pH and temperature), and they had similar IR patterns and similar elemental analysis results. The estimated chemical formula was [1Lu-1Cu-1Cl-1DOTMP] for both. The final product was synthesized at pH = 8 while stirring at room temperature using {sup 166}Dy/{sup 166}Ho-nitrate, CuCl{sub 2}, and DOTMP (yield > 99%, RTLC). Dynamic light scattering (DLS) measurements showed particles in the size range of 60 to 100 nm for the resultant radio-MOF particles (RMP). In vitro binding experiments showed acceptable bone-seeking affinity of the prepared formula even after one week of storage in human serum at 37 C. Importantly, this is the first study of the use of the MOF concept to provide a highly-stable organometallic compound containing {sup 166}Dy/{sup 166}Ho in vivo generator for bone marrow ablation.

  17. Generational diversity.

    Science.gov (United States)

    Kramer, Linda W

    2010-01-01

    Generational diversity has proven challenges for nurse leaders, and generational values may influence ideas about work and career planning. This article discusses generational gaps, influencing factors and support, and the various generational groups present in today's workplace as well as the consequences of need addressing these issues. The article ends with a discussion of possible solutions.

  18. "Asset Ownership Across Generations"

    OpenAIRE

    Ngina S. Chiteji; Frank P. Stafford

    2000-01-01

    This paper examines cross-generational connections in asset ownership. It begins by presenting a theoretical framework that develops the distinction between the intergenerational transfer of knowledge about financial assets and the direct transfer of dollars from parents to children. Its analysis of data from the Panel Study of Income Dynamics (PSID) reveals intergenerational correlations in asset ownership, and we find evidence to suggest that parental asset ownership or family-based exposur...

  19. The SOPHY Framework

    DEFF Research Database (Denmark)

    Laursen, Karl Kaas; Pedersen, Martin Fejrskov; Bendtsen, Jan Dimon

    The goal of the Sophy framework (Simulation, Observation and Planning in Hybrid Systems) is to implement a multi-level framework for description, simulation, observation, fault detection and recovery, diagnosis and autonomous planning in distributed embedded hybrid systems. A Java-based distributed...

  20. The SOPHY framework

    DEFF Research Database (Denmark)

    Laursen, Karl Kaas; Pedersen, M. F.; Bendtsen, Jan Dimon

    2005-01-01

    The goal of the Sophy framework (Simulation, Observation and Planning in Hybrid Systems) is to implement a multi-level framework for description, simulation, observation, fault detection and recovery, diagnosis and autonomous planning in distributed embedded hybrid systems. A Java-based distributed...

  1. Overlooking the Conceptual Framework

    Science.gov (United States)

    Leshem, Shosh; Trafford, Vernon

    2007-01-01

    The conceptual framework is alluded to in most serious texts on research, described in some and fully explained in few. However, examiners of doctoral theses devote considerable attention to exploring its function within social science doctoral vivas. A literature survey explores how the conceptual framework is itself conceptualised and explained.…

  2. Framework for the Future

    Science.gov (United States)

    Schuller, Tom

    2008-01-01

    The main goal of the Inquiry into the Future for Lifelong Learning is to provide a "strategic framework" for the future. In this article, the author considers the key components that will make up the framework. These are: (1) a statement of vision and values; (2) a stock-take of the current position; (3) an "investment…

  3. Does an Injection of Adipose-Derived Mesenchymal Stem Cells Loaded in Fibrin Glue Influence Rotator Cuff Repair Outcomes? A Clinical and Magnetic Resonance Imaging Study.

    Science.gov (United States)

    Kim, Yong Sang; Sung, Chang Hun; Chung, Sung Hoon; Kwak, Sang Joon; Koh, Yong Gon

    2017-07-01

    The mesenchymal stem cell (MSC)-based tissue engineering approach has been developed to improve the treatment of rotator cuff tears. Hypothesis/Purpose: The purpose was to determine the effect of an injection of adipose-derived MSCs loaded in fibrin glue during arthroscopic rotator cuff repair on clinical outcomes and to evaluate its effect on structural integrity using magnetic resonance imaging (MRI). The hypothesis was that the application of adipose-derived MSCs would improve outcomes after the surgical repair of a rotator cuff tear. Cohort study; Level of evidence, 3. Among 182 patients treated with arthroscopic surgery for a rotator cuff tear, 35 patients treated with arthroscopic rotator cuff repair alone (conventional group) were matched with 35 patients who underwent arthroscopic rotator cuff repair with an injection of adipose-derived MSCs loaded in fibrin glue (injection group) based on sex, age, and lesion size. Outcomes were assessed with respect to the visual analog scale (VAS) for pain, range of motion (ROM) (including forward flexion, external rotation at the side, and internal rotation at the back), and functional measures of the Constant score and University of California, Los Angeles (UCLA) shoulder rating scale. Repaired tendon structural integrity was assessed by using MRI at a minimum of 12 months after surgery, and the mean clinical follow-up was 28.8 ± 4.2 months in the conventional group and 28.3 ± 3.8 months in the injection group. The mean VAS score at rest and during motion improved significantly in both groups after surgery. However, there were no significant differences between the groups at the final follow-up ( P = .256 and .776, respectively). Compared with preoperative measurements, forward flexion and external rotation at the side significantly improved at the final follow-up in both groups (all P rotation at the back were observed in either group ( P = .625 and .834 for the conventional and injection groups, respectively

  4. Do medical students generate sound arguments during small group discussions in problem-based learning?: an analysis of preclinical medical students' argumentation according to a framework of hypothetico-deductive reasoning.

    Science.gov (United States)

    Ju, Hyunjung; Choi, Ikseon; Yoon, Bo Young

    2017-06-01

    Hypothetico-deductive reasoning (HDR) is an essential learning activity and a learning outcome in problem-based learning (PBL). It is important for medical students to engage in the HDR process through argumentation during their small group discussions in PBL. This study aimed to analyze the quality of preclinical medical students' argumentation according to each phase of HDR in PBL. Participants were 15 first-year preclinical students divided into two small groups. A set of three 2-hour discussion sessions from each of the two groups during a 1-week-long PBL unit on the cardiovascular system was audio-recorded. The arguments constructed by the students were analyzed using a coding scheme, which included four types of argumentation (Type 0: incomplete, Type 1: claim only, Type 2: claim with data, and Type 3: claim with data and warrant). The mean frequency of each type of argumentation according to each HDR phase across the two small groups was calculated. During small group discussions, Type 1 arguments were generated most often (frequency=120.5, 43%), whereas the least common were Type 3 arguments (frequency=24.5, 8.7%) among the four types of arguments. The results of this study revealed that the students predominantly made claims without proper justifications; they often omitted data for supporting their claims or did not provide warrants to connect the claims and data. The findings suggest instructional interventions to enhance the quality of medical students' arguments in PBL, including promoting students' comprehension of the structure of argumentation for HDR processes and questioning.

  5. Towards Next Generation BI Systems

    DEFF Research Database (Denmark)

    Varga, Jovan; Romero, Oscar; Pedersen, Torben Bach

    2014-01-01

    Next generation Business Intelligence (BI) systems require integration of heterogeneous data sources and a strong user-centric orientation. Both needs entail machine-processable metadata to enable automation and allow end users to gain access to relevant data for their decision making processes....... This framework is based on the findings of a survey of current user-centric approaches mainly focusing on query recommendation assistance. Finally, we discuss the benefits of the framework and present the plans for future work....

  6. Three-dimensional printing spiders: back-and-forth glue application yields silk anchorages with high pull-off resistance under varying loading situations.

    Science.gov (United States)

    Wolff, Jonas O; Herberstein, Marie E

    2017-02-01

    The anchorage of structures is a crucial element of construction, both for humans and animals. Spiders use adhesive plaques to attach silk threads to substrates. Both biological and artificial adhesive structures usually have an optimal loading angle, and are prone to varying loading situations. Silk anchorages, however, must cope with loading in highly variable directions. Here we show that the detachment forces of thread anchorages of orb-web spiders are highly robust against pulling in different directions. This is gained by a two-step back-and-forth spinning pattern during the rapid production of the adhesive plaque, which shifts the thread insertion point towards the plaque centre and forms a flexible tree root-like network of branching fibres around the loading point. Using a morphometric approach and a tape-and-thread model we show that neither area, nor width of the plaque, but the shift of the loading point towards the plaque centre has the highest effect on pull-off resistance. This is explained by a circular propagation of the delamination crack with a low peeling angle. We further show that silken attachment discs are highly directional and adjusted to provide maximal performance in the upstream dragline. These results show that the way the glue is applied, crucially enhances the toughness of the anchorage without the need of additional material intake. This work is a starting point to study the evolution of tough and universal thread anchorages among spiders, and to develop bioinspired 'instant' anchorages of thread- and cable-like structures to a broad bandwidth of substrates. © 2017 The Author(s).

  7. A quality framework for addiction treatment programs

    NARCIS (Netherlands)

    Nabitz, Udo; van den Brink, Wim; Walburg, Jan

    2005-01-01

    AIM: To identify and specify the structure and the elements of a quality framework for addiction treatment programs. METHOD: Concept mapping strategy was applied. In brainstorm sessions, 70 statements were generated and rated by 90 representatives of three stakeholder groups. Using multivariate

  8. A framework for consciousness.

    Science.gov (United States)

    Crick, Francis; Koch, Christof

    2003-02-01

    Here we summarize our present approach to the problem of consciousness. After an introduction outlining our general strategy, we describe what is meant by the term 'framework' and set it out under ten headings. This framework offers a coherent scheme for explaining the neural correlates of (visual) consciousness in terms of competing cellular assemblies. Most of the ideas we favor have been suggested before, but their combination is original. We also outline some general experimental approaches to the problem and, finally, acknowledge some relevant aspects of the brain that have been left out of the proposed framework.

  9. Isotope generator

    International Nuclear Information System (INIS)

    1979-01-01

    The patent describes an isotope generator incorporating the possibility of stopping elution before the elution vessel is completely full. Sterile ventilation of the whole system can then occur, including of both generator reservoir and elution vessel. A sterile, and therefore pharmaceutically acceptable, elution fluid is thus obtained and the interior of the generator is not polluted with non-sterile air. (T.P.)

  10. Instant Generation

    Science.gov (United States)

    Loveland, Elaina

    2017-01-01

    Generation Z students (born between 1995-2010) have replaced millennials on college campuses. Generation Z students are entrepreneurial, desire practical skills with their education, and are concerned about the cost of college. This article presents what need to be known about this new generation of students.

  11. Optimising generators

    Energy Technology Data Exchange (ETDEWEB)

    Guerra, E.J.; Garcia, A.O.; Graffigna, F.M.; Verdu, C.A. (IMPSA (Argentina). Generators Div.)

    1994-11-01

    A new computer tool, the ARGEN program, has been developed for dimensioning large hydroelectric generators. This results in better designs, and reduces calculation time for engineers. ARGEN performs dimensional tailoring of salient pole synchronous machines in generators, synchronous condensers, and generator-motors. The operation and uses of ARGEN are explained and its advantages are listed in this article. (UK)

  12. DXC'09 Framework

    Data.gov (United States)

    National Aeronautics and Space Administration — The DXC Framework is a collection of programs and APIs for running and evaluating diagnostic algorithms (DAs). It is complementary to system XML catalogs and...

  13. Conductive open frameworks

    Science.gov (United States)

    Yaghi, Omar M.; Wan, Shun; Doonan, Christian J.; Wang, Bo; Deng, Hexiang

    2018-05-22

    The disclosure relates generally to materials that comprise conductive covalent organic frameworks. The disclosure also relates to materials that are useful to store and separate gas molecules and sensors.

  14. VBE reference framework

    NARCIS (Netherlands)

    Afsarmanesh, H.; Camarinha-Matos, L.M.; Ermilova, E.; Camarinha-Matos, L.M.; Afsarmanesh, H.; Ollus, M.

    2008-01-01

    Defining a comprehensive and generic "reference framework" for Virtual organizations Breeding Environments (VBEs), addressing all their features and characteristics, is challenging. While the definition and modeling of VBEs has become more formalized during the last five years, "reference models"

  15. The stapl Skeleton Framework

    KAUST Repository

    Zandifar, Mani; Thomas, Nathan; Amato, Nancy M.; Rauchwerger, Lawrence

    2015-01-01

    from programmers and enables them to express parallel programs as a composition of existing elementary skeletons such as map, map-reduce, scan, zip, butterfly, allreduce, alltoall and user-defined custom skeletons. Skeletons in this framework

  16. Extensible Systems Dynamics Framework

    National Research Council Canada - National Science Library

    Brooks, Christopher; Lee, Edward A

    2008-01-01

    .... The Pedigree Management and Assessment Framework (PMAF) enables the publisher of information to record standard pedigree, such as information about the source, manner of collection, and the chain of modification of that information...

  17. BEX Mejora continua framework

    OpenAIRE

    García Ramírez, David

    2014-01-01

    Memoria de la implementación de un software que permite la gestión y control de todo el framework que requiere gestionar el departamento de mejora continua (BEX Business Excelence). Memòria de la implementació d'un programari que permet la gestió i control de tot el framework que requereix gestionar el departament de millora contínua (BEX Business Excelence). Master thesis for the Free Software program.

  18. Gender Dimensions Framework Application

    OpenAIRE

    Rubin, D.

    2011-01-01

    This is a presentation of the The Gender Dimensions Framework (GDF). The GDF was developed to provide guidance to USAID staff and partner organizations for working with USAID projects looking at promoting equitable opportunities in agricultural value chains. The GDF contemplates four dimensions: access to and control over key productive assets (tangible and intangible); beliefs and perceptions; practices and participation, and legal frameworks. CCRA-7 (Gendered Knowledge)

  19. Creating an outcomes framework.

    Science.gov (United States)

    Doerge, J B

    2000-01-01

    Four constructs used to build a framework for outcomes management for a large midwestern tertiary hospital are described in this article. A system framework outlining a model of clinical integration and population management based in Steven Shortell's work is discussed. This framework includes key definitions of high-risk patients, target groups, populations and community. Roles for each level of population management and how they were implemented in the health care system are described. A point of service framework centered on seven dimensions of care is the next construct applied on each nursing unit. The third construct outlines the framework for role development. Three roles for nursing were created to implement strategies for target groups that are strategic disease categories; two of those roles are described in depth. The philosophy of nursing practice is centered on caring and existential advocacy. The final construct is the modification of the Dartmouth model as a common framework for outcomes. System applications of the scorecard and lessons learned in the 2-year process of implementation are shared

  20. Endoscopic debridement and fibrin glue injection of a chronic Morel-Lavallée lesion of the knee in a professional soccer player: A case report and literature review.

    Science.gov (United States)

    Koc, Baris B; Somorjai, Nicolaas; P M Kiesouw, Egid; Vanderdood, Kurt; Meesters-Caberg, Marleen; Draijer, Frits W; Jansen, Edwin J P

    2017-01-01

    A Morel-Lavallée lesion is a post-traumatic closed degloving injury of soft tissue. The lesion is due to a shearing trauma with separation of subcutaneous tissue from underlying fascia. When conservative treatment fails, surgical treatment is imperative. Commonly, open drainage and debridement is performed. This case report describes a Morel-Lavallée lesion of the knee in a professional soccer player who was successfully treated with endoscopic debridement and fibrin glue injection after failure of conservative management. This method achieves the goal of an open surgical debridement without exposing patients to an increased morbidity. Copyright © 2016. Published by Elsevier B.V.

  1. Organic Nano-Grains in Comet 103P/Hartley 2: The Organic Glue of Porous Aggregate Grains?

    Science.gov (United States)

    Wooden, D. H.; Russo, N.Dello; Li, A.; Woodward, C. E.; Kelley, M. S.; Harker, D. E.; Cook, J. C.; Vervack, R. J.; Geballe, T. R.

    2013-01-01

    The GNIRS instrument on the Gemini 8-­-m telescope observed comet 103P/Hartley on 2010-­- Dec-­-04UT, a month after the EPOXI Mission encounter, and detected the 3.3 and 3.4 um bands in emission. The 3.3/3.4 ratio and the broad band widths are consistent with experiments of heated (approximately 600 K) aliphatic carbon (-CH3, -CH2) thin films. For the 3.4 micron band to be in emission, the aliphatic bonds must be attached to a carrier possessing the strongly UV-­-absorbing C=C aromatic rings, and these rings have to be less than 50-­-100 carbon atoms (4-6 Angstrom) for attached -CH bonds to also generate a 3.3 micron-band in emission. Slightly larger (=10Å) Very Small Grains (VSGs) can absorb single UV photons comparable to or exceeding their heat capacity, thermally fluctuate and release IR photon(s). The 3.3 micron and 3.4 micron bands observed by GNIRS suggest that organic macromolecules/ nano-­-grains with both aliphatic and aromatic bonds are fluorescing/thermally fluctuating in the coma. Aliphatic and aromatic materials have been seen in Stardust samples and the primitive carbonaceous chondrite 'Tagish Lake'. The larger the ratio of the -CH2/-CH3 components of the aliphatic 3.4 micron band, the more 'primitive' the organic material. In a Stardust organic globule, some aliphatic bonds were transformed into aromatic bonds during the low dosage of Transmission Electron Microscope imaging. Conversely, lab experiments show irradiation of ices containing small PAHs generates aliphatic organics. Photo-­-processing of ices also likely forms the ubiquitous aliphatic coatings that appear on the surfaces of all silicate subgrains constituting nine cometary interplanetary dust particles. The aliphatic coatings, dominated by -CH2, likely were important in sticking the aggregates together, and existed prior to incorporation of dust aggregates into comet nuclei. These comet aliphatics may be some of the sought-­-after precursors to the more robust and complex

  2. An XML-based framework for personalized health management.

    Science.gov (United States)

    Lee, Hiye-Ja; Park, Seung-Hun; Jeong, Byeong-Soo

    2006-01-01

    This paper proposes a framework for personalized health management. In this framework, XML technology is used for representing and managing the health information and knowledge. Major components of the framework are Health Management Prescription (HMP) Expert System and Health Information Repository. The HMP Expert System generates a HMP efficiently by using XML-based templates. Health Information Repository provides integrated health information and knowledge for personalized health management by using XML and relational database together.

  3. Framework for sequential approximate optimization

    NARCIS (Netherlands)

    Jacobs, J.H.; Etman, L.F.P.; Keulen, van F.; Rooda, J.E.

    2004-01-01

    An object-oriented framework for Sequential Approximate Optimization (SAO) isproposed. The framework aims to provide an open environment for thespecification and implementation of SAO strategies. The framework is based onthe Python programming language and contains a toolbox of Python

  4. Generative electronic background music system

    Energy Technology Data Exchange (ETDEWEB)

    Mazurowski, Lukasz [Faculty of Computer Science, West Pomeranian University of Technology in Szczecin, Zolnierska Street 49, Szczecin, PL (Poland)

    2015-03-10

    In this short paper-extended abstract the new approach to generation of electronic background music has been presented. The Generative Electronic Background Music System (GEBMS) has been located between other related approaches within the musical algorithm positioning framework proposed by Woller et al. The music composition process is performed by a number of mini-models parameterized by further described properties. The mini-models generate fragments of musical patterns used in output composition. Musical pattern and output generation are controlled by container for the mini-models - a host-model. General mechanism has been presented including the example of the synthesized output compositions.

  5. Generative electronic background music system

    International Nuclear Information System (INIS)

    Mazurowski, Lukasz

    2015-01-01

    In this short paper-extended abstract the new approach to generation of electronic background music has been presented. The Generative Electronic Background Music System (GEBMS) has been located between other related approaches within the musical algorithm positioning framework proposed by Woller et al. The music composition process is performed by a number of mini-models parameterized by further described properties. The mini-models generate fragments of musical patterns used in output composition. Musical pattern and output generation are controlled by container for the mini-models - a host-model. General mechanism has been presented including the example of the synthesized output compositions

  6. A qualitative evaluation approach for energy system modelling frameworks

    DEFF Research Database (Denmark)

    Wiese, Frauke; Hilpert, Simon; Kaldemeyer, Cord

    2018-01-01

    properties define how useful it is in regard to the existing challenges. For energy system models, evaluation methods exist, but we argue that many decisions upon properties are rather made on the model generator or framework level. Thus, this paper presents a qualitative approach to evaluate frameworks...

  7. Fuel upgrading and reforming with metal organic framework

    KAUST Repository

    Eddaoudi, Mohamed; Belmabkhout, Youssef

    2016-01-01

    Systems and methods for separating hydrocarbons on an internal combustion powered vehicle via one or more metal organic frameworks are disclosed. Systems and methods can further include utilizing separated hydrocarbons and exhaust to generate

  8. Wind Generators

    Science.gov (United States)

    1989-01-01

    When Enerpro, Inc. president, Frank J. Bourbeau, attempted to file a patent on a system for synchronizing a wind generator to the electric utility grid, he discovered Marshall Space Flight Center's Frank Nola's power factor controller. Bourbeau advanced the technology and received a NASA license and a patent for his Auto Synchronous Controller (ASC). The ASC reduces generator "inrush current," which occurs when large generators are abruptly brought on line. It controls voltage so the generator is smoothly connected to the utility grid when it reaches its synchronous speed, protecting the components from inrush current damage. Generator efficiency is also increased in light winds by applying lower than rated voltage. Wind energy is utilized to drive turbines to generate electricity for utility companies.

  9. The art framework

    International Nuclear Information System (INIS)

    Green, C; Kowalkowski, J; Paterno, M; Fischler, M; Garren, L; Lu, Q

    2012-01-01

    Future “Intensity Frontier” experiments at Fermilab are likely to be conducted by smaller collaborations, with fewer scientists, than is the case for recent “Energy Frontier” experiments. art is a C++ event-processing framework designed with the needs of such experiments in mind. An evolution from the framework of the CMS experiment, art was designed and implemented to be usable by multiple experiments without imposing undue maintenance effort requirements on either the art developers or experiments using it. We describe the key requirements and features of art and the rationale behind evolutionary changes, additions and simplifications with respect to the CMS framework. In addition, our package distribution system and our collaborative model with respect to the multiple experiments using art helps keep the maintenance burden low. We also describe in-progress and future enhancements to the framework, including strategies we are using to allow multi-threaded use of the art framework in today's multi- and many-core environments.

  10. Verification of the computer code ATHLET in the framework of the external verification group ATHLET BETHSY test 9.3 - steam generator U-tube rupture with failure of the high pressure injection. Final report; Verifikation des ATHLET-Rechenprogramms im Rahmen der externen Verifikationsgruppe ATHLET BETHSY Test 9.3 - Heizrohrbruch mit Versagen der Hochdruck-Noteinspeisung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Krepper, E.; Schaefer, F. [Forschungszentrum Rossendorf e.V. (FZR) (Germany). Inst. fuer Sicherheitsforschung

    1998-08-01

    In the framework of the external validation of the thermalhydraulic code ATHLET MOD 1.1 CYCLE D, which is being developed by the GRS, post test analyses of two experiments were done, which were performed at the French integral test facility BETHSY. During test 9.3 the consequences of a steam generator U-tube rupture with failure of the high pressure injection and of the auxiliary feedwater supply were investigated. As accident management measures, the depressurization of the secondary sides, first of the two intact steam generators, then of the damaged steam generator and finally the primary depressurization by opening of the pressurizer valve were performed. The results show, that the code ATHLET is able to describe the complex scenario in good accordance with the experiment. The safety relevant statement could be reproduced. Deviations, which did not impose the general results, occurred concerning the break mass flow during the depressurization of the damaged steam generator and the description of the failure of the heat transfer to the damaged steam generator. Reasons are hardly to find, because these processes are highly complex. (orig.) [Deutsch] Im Rahmen der externen Validierung des von der Gesellschaft fuer Anlagen- und Reaktorsicherheit entwickelten Stoerfallcodes ATHLET, der in der Version Mod 1.1 Cycle D vorlag, wurden zwei Experimente nachgerechnet und analysiert, die an der franzoesischen Versuchsanlage BETHSY durchgefuehrt wurden. Im Test 9.3 werden die Konsequenzen untersucht, wenn bei einem Heizrohrbruch die Hochdruckeinspeisung sowie die Not-Speisewasserversorgung der Dampferzeuger versagen und nur die Druckspeicher sowie die Niederdruckeinspeisung zur Verfuegung stehen. Als Accident Management Massnahmen wurde die sekundaere Druckentlastung und schliesslich die primaere Entlastung ueber den Druckhalter untersucht. Die Analyse kommt zu dem Ergebnis, dass der Code ATHLET in der Lage ist, dieses komplexe Szenario recht gut zu beschreiben. Die

  11. Generations and the Generation of Theory in Social Gerontology.

    Science.gov (United States)

    Hendricks, Jon

    1992-01-01

    Looks at theorizing in gerontology as career-related activity engaged in by scholars who are prone to same demographic imperatives as other human beings as way of shedding more light on many uses of theory. Uses concept of theoretical generations as means of accounting for succession of models and explanatory frameworks. (Author/NB)

  12. GENERATION OF IRREGULAR HEXAGONAL MESHES

    Directory of Open Access Journals (Sweden)

    Vlasov Aleksandr Nikolaevich

    2012-07-01

    Decomposition is performed in a constructive way and, as option, it involves meshless representation. Further, this mapping method is used to generate the calculation mesh. In this paper, the authors analyze different cases of mapping onto simply connected and bi-connected canonical domains. They represent forward and backward mapping techniques. Their potential application for generation of nonuniform meshes within the framework of the asymptotic homogenization theory is also performed to assess and project effective characteristics of heterogeneous materials (composites.

  13. FRAMEWORK FOR COMPARING SEGMENTATION ALGORITHMS

    Directory of Open Access Journals (Sweden)

    G. Sithole

    2015-05-01

    Full Text Available The notion of a ‘Best’ segmentation does not exist. A segmentation algorithm is chosen based on the features it yields, the properties of the segments (point sets it generates, and the complexity of its algorithm. The segmentation is then assessed based on a variety of metrics such as homogeneity, heterogeneity, fragmentation, etc. Even after an algorithm is chosen its performance is still uncertain because the landscape/scenarios represented in a point cloud have a strong influence on the eventual segmentation. Thus selecting an appropriate segmentation algorithm is a process of trial and error. Automating the selection of segmentation algorithms and their parameters first requires methods to evaluate segmentations. Three common approaches for evaluating segmentation algorithms are ‘goodness methods’, ‘discrepancy methods’ and ‘benchmarks’. Benchmarks are considered the most comprehensive method of evaluation. This paper shortcomings in current benchmark methods are identified and a framework is proposed that permits both a visual and numerical evaluation of segmentations for different algorithms, algorithm parameters and evaluation metrics. The concept of the framework is demonstrated on a real point cloud. Current results are promising and suggest that it can be used to predict the performance of segmentation algorithms.

  14. JASMINE Simulator - construction of framework

    Science.gov (United States)

    Yamada, Yoshiyuki; Ueda, Seiji; Kuwabara, Takashi; Yano, Taihei; Gouda, Naoteru

    2004-10-01

    JASMINE is an abbreviation of Japan Astrometry Satellite Mission for INfrared Exploration currently planned at National Astronomical Observatory of Japan. JASMINE stands at a stage where its basic design will be determined in a few years. Then it is very important for JASMINE to simulate the data stream generated by the astrometric fields in order to support investigations of accuracy, sampling strategy, data compression, data analysis, scientific performances, etc. It is found that the new software technologies of Object Oriented methodologies with Unified Modeling Language are ideal for the simulation system of JASMINE (JASMINE Simualtor). In this paper, we briefly introduce some concepts of such technologies and explain the framework of the JASMINE Simulator which is constructed by new technologies. We believe that these technologies are useful also for other future big projects of astronomcial research.

  15. A Framework for Systemic Design

    Directory of Open Access Journals (Sweden)

    Alex Ryan

    2014-12-01

    Full Text Available As designers move upstream from traditional product and service design to engage with challenges characterised by complexity, uniqueness, value conflict, and ambiguity over objectives, they have increasingly integrated systems approaches into their practice. This synthesis of systems thinking with design thinking is forming a distinct new field of systemic design. This paper presents a framework for systemic design as a mindset, methodology, and set of methods that together enable teams to learn, innovate, and adapt to a complex and dynamic environment. We suggest that a systemic design mindset is inquiring, open, integrative, collaborative, and centred. We propose a systemic design methodology composed of six main activities: framing, formulating, generating, reflecting, inquiring, and facilitating. We view systemic design methods as a flexible and open-ended set of procedures for facilitating group collaboration that are both systemic and designerly.  

  16. A framework for ALWR economics

    International Nuclear Information System (INIS)

    Braun, C.

    1993-01-01

    This paper discusses three major factors that determine the relative competitiveness of future advanced light water reactors (ALWRS) in comparison with then-concurrent fossil generation alternatives. These factors include: (a) ALWR capital cost assumptions, (b) fossil fuel prices (particularly natural gas price), and (c) ownership and financing arrangements, i.e., utility or independent power producer (IPP) plant ownership, construction, and operation. By properly selecting the right menu of assumptions, e.g., a low capital cost ALWR IPP versus a high gas price utility owner combined-cycle plant, one can investigate the competitiveness of future ALWRs under various ownership environments and the sensitivity of ALWR economics to different cost assumptions. Using standardized assumptions for fossil plant financing arrangements under different ownerships and plant capital cost and fuel price data, it is possible to create various frameworks into which ALWR cost assumptions could be inserted to investigate relative nuclear/fossil economics

  17. Generative Semantics

    Science.gov (United States)

    Bagha, Karim Nazari

    2011-01-01

    Generative semantics is (or perhaps was) a research program within linguistics, initiated by the work of George Lakoff, John R. Ross, Paul Postal and later McCawley. The approach developed out of transformational generative grammar in the mid 1960s, but stood largely in opposition to work by Noam Chomsky and his students. The nature and genesis of…

  18. Sound generator

    NARCIS (Netherlands)

    Berkhoff, Arthur P.

    2008-01-01

    A sound generator, particularly a loudspeaker, configured to emit sound, comprising a rigid element (2) enclosing a plurality of air compartments (3), wherein the rigid element (2) has a back side (B) comprising apertures (4), and a front side (F) that is closed, wherein the generator is provided

  19. Sound generator

    NARCIS (Netherlands)

    Berkhoff, Arthur P.

    2010-01-01

    A sound generator, particularly a loudspeaker, configured to emit sound, comprising a rigid element (2) enclosing a plurality of air compartments (3), wherein the rigid element (2) has a back side (B) comprising apertures (4), and a front side (F) that is closed, wherein the generator is provided

  20. Pulse Generator

    Science.gov (United States)

    Greer, Lawrence (Inventor)

    2017-01-01

    An apparatus and a computer-implemented method for generating pulses synchronized to a rising edge of a tachometer signal from rotating machinery are disclosed. For example, in one embodiment, a pulse state machine may be configured to generate a plurality of pulses, and a period state machine may be configured to determine a period for each of the plurality of pulses.