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Sample records for globules blancs possibilites

  1. Fixation of radioactive cerium-144 on white blood cells. Possibilities for use in physiopathology; Fixation du cerium radioactif ({sup 144}Ce) sur les globules blancs. Possibilites d'emploi en physiopathologie

    Energy Technology Data Exchange (ETDEWEB)

    Aeberhardt, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    From the study of the means of transport of cerium in the blood of various laboratory animals, after intra-venous injection of {sup 144}Ce-{sup 144}Pr without carrier, we have been able to show up the part played by the white cells in the transport of this fission product during its passage in the blood. This observation has led to the study, in vitro, of the methods of cerium fixation on the white cells, with a view to determining the possibilities of using this property for white cell labelling, the methods used up to the present not being entirely satisfactory. Using the method for the separation of the known constituents of the blood proposed by us in 1956, we have studied the cerium fixation under various conditions: - on suspensions of white cells from the rabbit, - on a suspension of human white cells, - on the white cells in whole from the rabbit. (author) [French] L'etude du mode de transport du cerium dans le sang chez differents animaux de laboratoire, apres injection intra-veineuse de {sup 144}Ce-{sup 144}Pr sans entraineur, nous a permis de mettre en evidence le rale des globules blancs dans le transport de ce produit de fission au cours de son passage dans le sang. Cette constatation nous a conduit a etudier, in vitro, les modalites de la fixation du cerium sur les globules blancs afin de preciser les possibilites d'utilisation de cette propriete pour le marquage des globules blancs, les methodes employees jusqu'ici ne donnant pas entiere satisfaction. Disposant de la methode de separation des elements figures du sang que nous avons proposee en 1956, nous avons etudie la fixation du cerium, dans diverses conditions: - sur des suspensions de globules blancs de lapin, - sur une suspension de globules blancs humains, - sur les globules blancs dans le sang total de lapin. (auteur)

  2. Dusty Globules and Globulettes

    Science.gov (United States)

    Grenman, Tiia

    2018-05-01

    Interstellar gas and dust can condense into clouds of very different size, ranging from giant molecular cloud complexes to massive, isolated, dark cloudlets, called globules with a few solar masses. This thesis focuses on a new category of small globules, named globulettes. These have been found in the bright surroundings of H II regions of young, massive stellar clusters. The globulettes are much smaller and less massive than normal globules. The analysis is based on H-alpha images of e.g., the Rosette Nebula and the Carina Nebula collected with the Nordic Optical Telescope and the Hubble Space Telescope. Most globulettes found in different H II regions have distinct contours and are well isolated from the surrounding molecular shell structures. Masses and densities were derived from the extinction of light through the globulettes and the measured shape of the objects. A majority of the globulettes have planetary masses, disintegration of large molecular clouds originally hosting compact and small cores. At a later stage, globulettes expand, disrupt or evaporate. However, preliminary calculations of their lifetimes show that some might survive for a relatively long time, in several cases even longer than their estimated contraction time. The tiny high density globulettes in the Carina Nebula indicate that they are in a more evolved state than those in the Rosette Nebula, and hence they may have survived for a longer time. It is possible that the globulettes could host low mass brown dwarfs or planets. Using the virial theorem on the Rosette Nebula globulettes and including only the thermal and gravitational potential energy indicated that the 133 found globulettes are all either expanding or disrupting. When the ram and the radiation pressure were included, we found that about half of our objects are gravitationally bound or unstable to contraction and could collapse to form brown dwarfs or free floating planets. We also estimated the amount of globulettes and the

  3. Michel Blanc 1952-2009

    CERN Multimedia

    HR Department

    2009-01-01

    We deeply regret to announce the death of Mr Michel BLANC on 27 November 2009. Mr BLANC, who was born on 4 April 1952, was a member of the IT Department and had worked at CERN since 1 January 1978. The Director-General has sent his family a message of condolence on behalf of the CERN personnel. Social Affairs It was with great sadness that we learned of the death of our friend and colleague Michel Blanc on the evening of Friday 27 November. Everyone who knew him, especially those who had spent many years with him in the Computer Centre where he worked since his arrival at CERN in 1978, but also his more recent colleagues, will always remember his good humour, his quick wit and his amazing zest for life. He made staunch friends during his thirty years at CERN and often kept in touch with them after they left the Organization. His passion for motorcycling and for walks with his wife, his two sons and his friends were some of his great joys in life. Michel took a well-earned early retirement in Octobe...

  4. Aasta film - joonisfilm "Mont Blanc" / Verni Leivak

    Index Scriptorium Estoniae

    Leivak, Verni, 1966-

    2002-01-01

    Eesti Filmiajakirjanike Ühing andis aasta 2001 parima filmi tiitli Priit Tenderi joonisfilmile "Mont Blanc" : Eesti Joonisfilm 2001.Ka filmikriitikute eelistused kinodes ja televisioonis 2001. aastal näidatud filmide osas

  5. Infrared radiation from dark globules

    International Nuclear Information System (INIS)

    Spencer, R.G.; Leung, C.M.

    1978-01-01

    Theoretical models are constructed by which to study the infrared emission from dark globules heated by the interstellar radiation field (ISRF). The effects of cloud parameters (grain type, optical depth, and density inhomogeneity) on the emergent spectrum and infrared surface brightnesses are studied. Compared with clouds which have internal heat sources, the emergent flux for globules is found to be at least a factor of 10 smaller and to peak at wavelengths 100 μm< or =lambda< or =130 μm for graphite clouds and 310 μm< or =lambda< or =550 μm for silicate clouds. Either limb brightening or limb darkening in the infrared can occur, which depends sensitively on the optical depth. For globules of moderate extinction (greater than approx.10 in the visible), significant infrared limb brightening occurs at wavelengths of grain emission (20 μm< or =lambda< or =600 μm). A physical interpretation of these results is presented. To help remove ambiguities from interpretations of future observations, the observable effects of a grain mixture, variation of the ISRF, as well as beam dilution are examined in detail. The presence of a second grain component alters the emergent spectrum significantly. For a variation of the ISRF within wide limits, the ratio of surface to central temperature (T/sub s//T/sub c/) of an optically thick cloud remains fairly constant (3< or approx. =T/sub s//T/sub c/< or approx. =4). Infrared limb brightening may be smoothed out by beam dilution as well as by density inhomogeneities. Finally, the expected flux densities in the infrared of a typical globule are presented for different beam sizes. The predicted fluxes are within the detection threshold of currently available infrared detectors, using either ground-based or balloon-borne telescopes

  6. Microwave spectral lines in galactic dust globules

    International Nuclear Information System (INIS)

    Martin, R.N.; Barrett, A.H.

    1978-01-01

    In order to better understand galactic dust globules, a program of mapping several molecular transitions in these clouds has been undertaken. The results of observations of the J=1→0 rotational transitions of CO, 13 CO, C 18 O, and CS, the J=2→1rotational transitions of CS and C 34 S, the J, K=1, 1 and J, K=2, 2 inversion transitions of NH 3 , the J/sub KKprime/=1 11 →1 10 and J/sub KKprime/=2 12 →2 11 transitions of H 2 CO, and the OH 2 Pi/sub 3/2/F=2→2 and F=1→1 transitions are reported here. Twelve globules have been selected for observation; seven of these were studied in detail and the remainder observed only sparsely. A strong positive correlation appears to exist between the spatial extent of the molecular emission (or absorption) and the optical features of the globule. Even the main isotope of CO shows this correlation between dust extinction and molecular emission. Close examination of the Palomar prints reveals dust wherever CO is observed, and CO is probably a good tracer of dust extinction.The simultaneous observation of many molecular transitions has proven useful in obtaining reliable physical parameters for the dust globules. For example, CO and NH 3 are reliable thermometers of the kinetic temperature, and CS and NH 3 are indicators of the total gas density. The kinetic temperatures of the globules are almost always approx.10 K, and the derived H 2 densities are 10/sup 3.4/-10/sup 4.5/ cm -3 . The density in the core of the globules could well be larger than these value, which represent an average for the entire cloud. The kinetic temperature appears uniform across each cloud (within a few kelvins), in agreement with theoretical predictions. All of the globules studied in detail appear to be gravitationally bound and collapsing objects. Rotation has been observed in at least two globules (B163 and B163 SW). The projected axis of rotation is in a direction opposite to that of the Galaxy

  7. Neutrino astronomy at Mont Blanc: from LSD to LSD-2

    International Nuclear Information System (INIS)

    Saavedra, O.; Aglietta, M.; Badino, G.

    1988-01-01

    In this paper we present the upgrading of the LSD experiment, presently running in the Mont Blanc Laboratory. The data recorded during the period when supernova 1987A exploded are analysed in detail. The research program of LSD-2, the same experiment as LSD but with an higher sensitivity to search for neutrino burst from collapsing stars, is also discussed

  8. Deep underground multiple muons at the Mt. Blanc station

    Energy Technology Data Exchange (ETDEWEB)

    Bergamasco, L; Bilokon, H; D' Ettorre Piazzoli, B; Mannocchi, G [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Castagnoli, C; Picchi, P [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Turin Univ. (Italy). Ist. di Fisica Generale)

    1979-12-29

    Results on multiple events recorded at the Mt. Blanc station in the last 3 years are presented. The integral energy spectrum of muons is obtained for Esub(..mu..)>1 TeV in the size range 10/sup 6/ - 10/sup 7/ which favours a multiplicity law for hadronic interactions of the form eta approximately Esup(1/4).

  9. Stopping particles in the Mont Blanc spark chamber telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Bergamasco, L; Bilokon, H; Piazzoli, B E; Mannocchi, G; Picchi, P [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Turin Univ. (Italy). Ist. di Fisica Generale)

    1982-02-01

    We present the final results on the ratio of stopping to traversing muons as measured by two spark chamber telescopes in the Mont Blanc Station, Italy, at 4300 hg/cm/sup 2/. The experimental results are in agreement with the theoretical values within the limits of the error.

  10. A conspicuous globule in the Southern Coalsack

    International Nuclear Information System (INIS)

    Bok, B.J.; Sim, M.E.; Hawarden, T.G.

    1977-01-01

    It is stated that the Southern Coalsack is the finest dark nebula in the Southern Milky Way. Two photographs are here shown taken in October 1976 with the SRC 1.2 m Schmidt telescope at the Siding Spring Observatory, Australia. These show the whole of the Coalsack in all its beauty, and its features are discussed. It is shown how much can be learned by simple star counting techniques. A large number of potential globules are indicated, some of which are described. (U.K.)

  11. Far-infrared observations of globules

    International Nuclear Information System (INIS)

    Keene, J.

    1981-01-01

    Observations of far-infrared emission from nine globules are presented. The intensity and uniformity of the emission confirm that the heat source is the interstellar radiation field. Spectra of B133 and B335 are presented; they are consistent with optically thin thermal emission from dust with temperature 13--16 K. The emissivity of the grains must fall as fast as lambda -2 for lambda>500 μm. The temperature and intensity of B335 are used to calculate the ratio of visual extinction to far-infrared emission frequency

  12. Hier ist wahrhaftig ein Loch im Himmel. The NGC 1999 dark globule is not a globule

    Science.gov (United States)

    Stanke, T.; Stutz, A. M.; Tobin, J. J.; Ali, B.; Megeath, S. T.; Krause, O.; Linz, H.; Allen, L.; Bergin, E.; Calvet, N.; di Francesco, J.; Fischer, W. J.; Furlan, E.; Hartmann, L.; Henning, T.; Manoj, P.; Maret, S.; Muzerolle, J.; Myers, P. C.; Neufeld, D.; Osorio, M.; Pontoppidan, K.; Poteet, C. A.; Watson, D. M.; Wilson, T.

    2010-07-01

    The NGC 1999 reflection nebula features a dark patch with a size of 10 000 AU, which has been interpreted as a small, dense foreground globule and possible site of imminent star formation. We present Herschel PACS far-infrared 70 and 160 μm maps, which reveal a flux deficit at the location of the globule. We estimate the globule mass needed to produce such an absorption feature to be a few tenths to a few {M}⊙. Inspired by this Herschel observation, we obtained APEX LABOCA and SABOCA submillimeter continuum maps, and Magellan PANIC near-infrared images of the region. We do not detect a submillimer source at the location of the Herschel flux decrement; furthermore our observations place an upper limit on the mass of the globule of 2.4×10-2 {M}⊙. Indeed, the submillimeter maps appear to show a flux depression as well. Furthermore, the near-infrared images detect faint background stars that are less affected by extinction inside the dark patch than in its surroundings. We suggest that the dark patch is in fact a hole or cavity in the material producing the NGC 1999 reflection nebula, excavated by protostellar jets from the V 380 Ori multiple system. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASAThis publication includes data acquired with the Atacama Pathfinder Experiment (APEX; proposal E-082.F-9807 and E-284.C-5015). APEX is a collaboration between the Max-Planck-Institut für Radioastronomie, the European Southern Observatory, and the Onsala Space Observatory. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.Appendices A and B are only available in electronic form at http://www.aanda.org

  13. David Rosenthal’s Tirant lo Blanc turns 30

    Directory of Open Access Journals (Sweden)

    Jan Reinhart

    2014-12-01

    Full Text Available The groundbreaking English language translation of Tirant lo Blanc by New York poet and academic David Rosenthal remains dominant three decades after its initial, and celebrated, release. Rosenthal’s controversially fluid and concise rendering of the Valencian classic survived a serious challenge 20 years ago by a more literal version from a well-meaning amateur translator and journeyman academic backed by a leading U.S.-based Catalan scholar. The article reviews the controversy and compares the two versions, adding comments from some of the key critics. La traducció capdavantera a l’anglés del Tirant lo Blanc, feta pel poeta i erudit de Nova York, David Rosenthal, continua mantenint la seua importància, tres dècades després de publicar-se. La polèmica versió dúctil i concisa de Rosenthal del clàssic valencià, ha sobreviscut el desafiament seriós, de fa vint anys, de la versió més literal d’un benintencionat traductor amateur i acadèmci oficial, recolzat per un destacat erudit català establert als Estats Units. L’article revisa la polèmica i compara les dues versions, tot afegint els comentaris d’alguns dels crítics més importants.

  14. Fractal Globule as a model of DNA folding in eukaryotes

    Science.gov (United States)

    Imakaev, Maksim; Mirny, Leonid

    2012-02-01

    A recent study (Lieberman-Aiden et al., Science, 2009) observed that the structure of the genome, on the scale of a few megabases, is consistent with a fractal globule. The fractal globule is a quasi-equilibrium state of a polymer after a rapid collapse. First proposed theoretically in 1988, this structure had never been simulated. Fractal globule was seen as a state, in which each subchain is compact, and doesn't mix with other subchains due to their mutual unentanglement (topological constraints). We use GPU-assisted dynamics to create fractal globules of different sizes and observe their dynamics. Our simulations confirm that a polymer after rapid collapse has compact subchains. We measure the scaling of looping probability of a subchain with it's length, and observe the remarkably robust inverse proportionality. Dynamic simulation of the equilibration of this state show that it exhibits Rose type subdiffusion. Due to diffusion, fractal globule quickly degrades to a quasi-equilibrium state, in which subchains of a polymer are mixed, but topologically unentangled. We propose that separation of spatial and topological equilibration of a polymer chain might have implications in different fields of physics.

  15. Patrick Blanc'i rippuvad aiad / Urmas Grišakov

    Index Scriptorium Estoniae

    Grišakov, Urmas, 1942-2013

    2010-01-01

    Prantsuse botaaniku ja aiakujundaja Patrick Blanc'i taeva poole kõrguvad rohelised seinad võimaldavad tänapäeval imetleda inimese loovuse ja teadmiste koostöös sündinut. Kujundaja on oma töödega tõestanud, et taimed võivad edukalt kasvada ka vertikaalselt üksteise kohal. Patrick Blanc'i kodulehekülg: www.verticalgardenpatrickblanc.com

  16. Polarization measurements of the Bok globule B361

    Energy Technology Data Exchange (ETDEWEB)

    Williams, I P; Vedi, K [Queen Mary Coll., London (UK); Griffiths, W K [Leeds Univ. (UK); Bhatt, H C; Kulkarni, P V; Ashok, N M [Physical Research Lab., Ahmedabad (India); Wallis, R E [Royal Greenwich Observatory, Hailsham (UK)

    1985-01-01

    The results of the first measurements of the polarization of light from background stars passing through B361 are described. Nearly all the stars show that the direction of the polarized light is approximately north-south. If the polarization is caused by aligned grains within the globule then a magnetic field of the order of 50-100 ..mu..G is required. Both polarimetry and photometry confirm that two of the stars studied are very distant background stars while three of these stars were found to be foreground stars. The analysis indicates that the globule is not further away than 650 pc, but can only establish an approximate upper limit.

  17. La technologie offre de nouvelles possibilités aux femmes | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    information et de la communication (TIC), il ne s'agit pas d'une simple question de fossé numérique à combler. À son avis, il s'agit en fait d'exploiter les possibilités des TIC non seulement en tant qu'outils de communication, mais ...

  18. Effect of some stabilizing agents on globule characteristics and ...

    African Journals Online (AJOL)

    This study investigated the effects of some stabilizing agents (cassava, maize and bentonite mucilages) on globule characteristics and rheological properties of oil in water emulsions. Emulsions were prepared by mixing varying proportions of the mucilages with Arachis oil in the ratio of 60:40 (oil: water) with the aid of a ...

  19. Rosette nebula globules: Seahorse giving birth to a star

    Science.gov (United States)

    Mäkelä, M. M.; Haikala, L. K.; Gahm, G. F.

    2017-09-01

    Context. The Rosette nebula is an H II region ionized mainly by the stellar cluster NGC 2244. Elephant trunks, globules, and globulettes are seen at the interface where the H II region and the surrounding molecular shell meet. Aims: We have observed a field in the northwestern part of the Rosette nebula where we study the small globules protruding from the shell. Our aim is to measure their properties and study their star-formation history in continuation of our earlier study of the features of the region. Methods: We imaged the region in broadband near-infrared (NIR) JsHKs filters and narrowband H2 1-0 S(1), Pβ, and continuum filters using the SOFI camera at the ESO/NTT. The imaging was used to study the stellar population and surface brightness, create visual extinction maps, and locate star formation. Mid-infrared (MIR) Spitzer IRAC and WISE and optical NOT images were used to further study the star formation and the structure of the globules. The NIR and MIR observations indicate an outflow, which is confirmed with CO observations made with APEX. Results: The globules have mean number densities of 4.6 × 104 cm-3. Pβ is seen in absorption in the cores of the globules where we measure visual extinctions of 11-16 mag. The shell and the globules have bright rims in the observed bands. In the Ks band 20 to 40% of the emission is due to fluorescent emission in the 2.12 μmH2 line similar to the tiny dense globulettes we studied earlier in a nearby region. We identify several stellar NIR excess candidates and four of them are also detected in the Spitzer IRAC 8.0 μm image and studied further. We find an outflow with a cavity wall bright in the 2.124 μmH2 line and at 8.0 μm in one of the globules. The outflow originates from a Class I young stellar object (YSO) embedded deep inside the globule. An Hα image suggests the YSO drives a possible parsec-scale outflow. Despite the morphology of the globule, the outflow does not seem to run inside the dusty fingers

  20. Milk fat globule membrane and buttermilks: from composition to valorization

    Directory of Open Access Journals (Sweden)

    Vanderghem, C.

    2010-01-01

    Full Text Available Buttermilk, the by-product from butter manufacture, is low cost and available in large quantities but has been considered for many years as invaluable. However, over the last two decades it has gained considerable attention due to its specific composition in proteins and polar lipids from the milk fat globule membrane (MFGM. The aim of this review is to take stock of current buttermilk knowledge. Firstly, the milk fat globule membrane composition and structure are described. Secondly, buttermilk and its associated products are defined according to the milk fat making process. Structure and mean composition of these products are summarized from recent dairy research data and related to technological properties, especially the emulsifying properties provided by MFGM components. Finally, new applications are presented, leading to promising valorizations of buttermilk and its derivate products.

  1. Le savoir offre aux jeunes des milieux urbains d'autres possibilités ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 août 2016 ... Un examen approfondi de la violence juvénile permet de dégager diverses solutions pour prévenir la criminalité, notamment des ressources de soutien en santé mentale, le renforcement de la confiance au sein de la collectivité, le maintien des jeunes à l'école et la création de possibilités d'emploi.

  2. In situ observation of D-rich carbonaceous globules embedded in NWA 801 CR2 chondrite

    Science.gov (United States)

    Hashiguchi, Minako; Kobayashi, Sachio; Yurimoto, Hisayoshi

    2013-12-01

    Eighty-five D-rich carbonaceous particles were identified in the matrix of the NWA 801 CR2 chondrite using isotope microscopy. The occurrence of 67 D-rich carbonaceous particles was characterized using secondary electron microscopy combined with X-ray elemental mapping. The close association of H and C, and D-enrichment suggests that the D-rich carbonaceous particles correspond to organic matter. The D-rich organic particles were scattered ubiquitously throughout the matrix at a concentration of approximately 660 ppm. The morphology of the D-rich carbonaceous particles is globular up to about 1 μm in diameter and is classified into four types: ring globules, round globules, irregular-shaped globules, and globule aggregates. The ring globules are ring-shaped organic matter containing silicate and/or oxide, with or without a void in the center. This is the first report of silicate and oxide grains surrounded by D-rich organic matter. The globule aggregates are composed of several D-rich organic globules mixed with silicates. Morphology of ring globules is very similar to core-mantle grain produced in the molecular cloud or in the outer solar nebula inferring by astronomy, suggesting that the organic globules have formed by UV photolysis in the ice mantle. Silicates or oxides attached to D-rich organic globules are the first observation among chondrites so far and may be unique nature of CR2 chondrites. The hydrogen isotopic compositions of the ring globules, round globules, irregular-shaped globules, and globule aggregates are δD = 3000-4800, 2900-8100, 2700-11,000, and 2500-11,000‰, respectively. Variations of D/H ratio of these organic globules seemed to be attributed to variations of D/H ratio of the organic radicals or differences of content of the D-rich organic radicals. There are no significant differences in the hydrogen isotopic compositions among the four types of D-rich carbonaceous matter. The D-enrichments suggest that these organic globules have

  3. Dust in the outer layers of the Barnard 5 globule

    Science.gov (United States)

    Il'in, V. B.; Efimov, Yu S.; Khudyakova, T. N.; Prokopjeva, M. S.; Varivoda, V. V.

    2018-04-01

    We present the results of our UBVRI polarimetric observations of a dozen stars located close to the well-studied Bok globule Barnard 5 (B5), with several of the stars being seen through its outer layers (with AV up to ˜3 mag). Using recent astrometric, spectroscopic and photometric surveys, we estimate the distance, spectral class and visual extinction for the observed stars and find that the results are in a good agreement with the available 3D extinction maps. We use a two-layer dust model of interstellar polarization towards B5, in which the layer closer to us is an extension of the Taurus cloud complex, and the farther one (including B5 and its halo) is related to the Perseus cloud complex (d ≈ 280-350 pc). Using spectral, photometric and polarimetric data on about 30 additional stars, we estimate the parameters of the former layer as λmax ≈ 0.56 μm, Pmax ≈ 0.7 per cent, θ ≈ 50°, AV ≈ 0.7 mag, and show that the observed wavelength dependence of the position angle for the stars observed generally agrees with the two-layer model. We find that when the stars are seen through the globule layers with AV = 2-3 mag, λmax ≈ 0.6-0.8 μm, which differs significantly from the λmax = 0.52-0.58 μm obtained by us for the diffuse interstellar medium in the direction of B5. We discuss the correlation of λmax with the optical thickness into the globule as well as other correlations of the extinction and polarization parameters.

  4. Milk fat globules: fatty acid composition, size and in vivo regulation of fat liquidity.

    Science.gov (United States)

    Timmen, H; Patton, S

    1988-07-01

    Populations of large and small milk fat globules were isolated and analyzed to determine differences in fatty acid composition. Globule samples were obtained by centrifugation from milks of a herd and of individual animals produced under both pasture and barn feeding. Triacylglycerols of total globule lipids were prepared by thin layer chromatography and analyzed for fatty acid composition by gas chromatography. Using content of the acids in large globules as 100%, small globules contained fewer short-chain acids, -5.9%, less stearic acid, -22.7%, and more oleic acids, +4.6%, mean values for five trials. These differences are consistent with alternative use of short-chain acids or oleic acid converted from stearic acid to maintain liquidity at body temperature of milk fat globules and their precursors, intracellular lipid droplets. Stearyl-CoA desaturase (EC 1.14.99.5), which maintains fluidity of cellular endoplasmic reticulum membrane, is suggested to play a key role in regulating globule fat liquidity. Possible origins of differences between individual globules in fatty acid composition of their triacylglycerols are discussed.

  5. Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

    DEFF Research Database (Denmark)

    Kjærgaard, Magnus; Teilum, Kaare; Poulsen, Flemming M

    2010-01-01

    Native molten globules are the most folded kind of intrinsically disordered proteins. Little is known about the mechanism by which native molten globules bind to their cognate ligands to form fully folded complexes. The nuclear coactivator binding domain (NCBD) of CREB binding protein is particul......Native molten globules are the most folded kind of intrinsically disordered proteins. Little is known about the mechanism by which native molten globules bind to their cognate ligands to form fully folded complexes. The nuclear coactivator binding domain (NCBD) of CREB binding protein....... Biophysical studies show that despite the molten globule nature of the domain, it contains a small cooperatively folded core. By NMR spectroscopy, we have demonstrated that the folded core of NCBD has a well ordered conformer with specific side chain packing. This conformer resembles the structure of the NCBD...

  6. The research program of the Liquid Scintillation Detector (LSD) in the Mont Blanc Laboratory

    Science.gov (United States)

    Dadykin, V. L.; Yakushev, V. F.; Korchagin, P. V.; Korchagin, V. B.; Malgin, A. S.; Ryassny, F. G.; Ryazhskaya, O. G.; Talochkin, V. P.; Zatsepin, G. T.; Badino, G.

    1985-01-01

    A massive (90 tons) liquid scintillation detector (LSD) has been running since October 1984 in the Mont Blanc Laboratory at a depth of 5,200 hg/sq cm of standard rock. The research program of the experiment covers a variety of topics in particle physics and astrophysics. The performance of the detector, the main fields of research are presented and the preliminary results are discussed.

  7. Molecular cloning and expression of gene encoding aromatic amino acid decarboxylase in 'Vidal blanc' grape berries.

    Science.gov (United States)

    Pan, Qiu-Hong; Chen, Fang; Zhu, Bao-Qing; Ma, Li-Yan; Li, Li; Li, Jing-Ming

    2012-04-01

    The pleasantly fruity and floral 2-phenylethanol are a dominant aroma compound in post-ripening 'Vidal blanc' grapes. However, to date little has been reported about its synthetic pathway in grapevine. In the present study, a full-length cDNA of VvAADC (encoding aromatic amino acid decarboxylase) was firstly cloned from the berries of 'Vidal blanc', an interspecific hybrid variety of Vitis vinifera × Vitis riparia. This sequence encodes a complete open reading frame of 482 amino acids with a calculated molecular mass of 54 kDa and isoelectric point value (pI) of 5.73. The amino acid sequence deduced shared about 79% identity with that of aromatic L: -amino acid decarboxylases (AADCs) from tomato. Real-time PCR analysis indicated that VvAADC transcript abundance presented a small peak at 110 days after full bloom and then a continuous increase at the berry post-ripening stage, which was consistent with the accumulation of 2-phenylethanol, but did not correspond to the trends of two potential intermediates, phenethylamine and 2-phenylacetaldehyde. Furthermore, phenylalanine still exhibited a continuous increase even in post-ripening period. It is thus suggested that 2-phenylethanol biosynthetic pathway mediated by AADC exists in grape berries, but it has possibly little contribution to a considerable accumulation of 2-phenylethanol in post-ripening 'Vidal blanc' grapes.

  8. Classification of Argentinean Sauvignon blanc wines by UV spectroscopy and chemometric methods.

    Science.gov (United States)

    Azcarate, Silvana Mariela; Cantarelli, Miguel Ángel; Pellerano, Roberto Gerardo; Marchevsky, Eduardo Jorge; Camiña, José Manuel

    2013-03-01

    Argentina is an important worldwide wine producer. In this country, there are several recognizable provinces that produce Sauvignon blanc wines: Neuquén, Río Negro, Mendoza, and San Juan. The analysis of the provenance of these white wines is complex and requires the use of expensive and time-consuming techniques. For this reason, this work discusses the determination of the provenance of Argentinean Sauvignon blanc wines by the use of UV spectroscopy and chemometric methods, such as principal component analysis (PCA), cluster analysis (CA), linear discriminant analysis (LDA), and partial least square discriminant analysis (PLS-DA). The proposed method requires low-cost equipment and short-time analysis in comparison with other techniques. The results are in very good agreement with results based on the geographical origin of Sauvignon blanc wines. This manuscript describes a method to determine the geographical origin of Sauvignon wines from Argentina. The main advantage of this method is the use of nonexpensive techniques, such as UV-Vis spectroscopy. © 2013 Institute of Food Technologists®

  9. Chromatin in fractal globule state: evidence from comet assay

    Directory of Open Access Journals (Sweden)

    Afanasieva K. S.

    2015-04-01

    Full Text Available At higher order levels chromatin is organized into loops that appear as a result of contacts between distant loci. The aim of this work was to investigate the length distribution of the DNA loops in nucleoids obtained after lysis of either whole cells or isolated cell nuclei. Methods. We used single cell gel electrophoresis to analyze the kinetics of the DNA loop migration from the two nucleoid types. Results. The kinetics of the DNA exit was found to have specific features for the two types of nucleoids. At the same time, in both cases, the DNA amount in the electrophoretic track depends linearly on the length of the longest loops in the track. Conclusions. We have concluded that for the loops up to ~ 100 kb the length distribution appears to be consistent with the fractal globule organization.

  10. Star-Formation in Free-Floating Evaporating Gaseous Globules

    Science.gov (United States)

    Sahai, Raghvendra

    2017-08-01

    We propose to study the stellar embryos in select members of a newly recognized class of Free-floating Evaporating Gaseous Globules (frEGGS) embedded in HII regions and having head-tail shapes. We discovered two of these in the Cygnus massive star-forming region (MSFR) with HST, including one of the most prominent members of this class (IRAS20324). Subsequent archival searches of Spitzer imaging of MSFRs has allowed us to build a statistical sample of frEGGs. Our molecular-line observations show the presence of dense molecular cores with total gas masses of (0.5-few) Msun in these objects, and our radio continuum images and Halpha images (from the IPHAS survey) reveal bright photo-ionized peripheries around these objects. We hypothesize that frEGGs are density concentrations originating in giant molecular clouds, that, when subject to the sculpting and compression by strong winds and UV radiation from massive stars, become active star-forming cores. For the 4 frEGGs with HST or near-IR AO images showing young stars and bipolar cavities produced by their jets or collimated outflows, the symmetry axis points roughly toward the external ionizing star or star cluster - exciting new evidence for our overpressure-induced star formation hypothesis. We propose to test this hypothesis by imaging 24 frEGGs in two nearby MSFRs that represent different radiation-dominated environments. Using ACS imaging with filters F606W, F814W, & F658N (Ha+[NII]), we will search for jets and outflow-excavated cavities, investigate the stellar nurseries inside frEGGs, and determine whether the globules are generally forming multiple star systems or small clusters, as in IRAS20324.

  11. Accroître les possibilités pour les jeunes vulnérables : entendre leur ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... baisse de la pauvreté et une augmentation des possibilités sur le marché du travail. ... Pays d' institution. Chile. Site internet. http://www.espaciopublico.cl ... En partenariat avec l'Organization for Women in Science for the Developing World ...

  12. Climbing Mont Blanc - A Training Site for Energy Efficient Programming on Heterogeneous Multicore Processors

    OpenAIRE

    Natvig, Lasse; Follan, Torbjørn; Støa, Simen; Magnussen, Sindre; Guirado, Antonio Garcia

    2015-01-01

    Climbing Mont Blanc (CMB) is an open online judge used for training in energy efficient programming of state-of-the-art heterogeneous multicores. It uses an Odroid-XU3 board from Hardkernel with an Exynos Octa processor and integrated power sensors. This processor is three-way heterogeneous containing 14 different cores of three different types. The board currently accepts C and C++ programs, with support for OpenCL v1.1, OpenMP 4.0 and Pthreads. Programs submitted using the graphical user in...

  13. qualite des eaux du bandama-blanc (cote d'ivoire) et de ses ...

    African Journals Online (AJOL)

    La qualité écologique des eaux des localités soumises à l'exploitation artisanale et clandestine de l'or au niveau du Bandama-Blanc et de ses affluents a été étudiée entre le 01 et le 15 Avril 2015. Le prélèvement du phytoplancton a été réalisé à l'aide de la bouteille hydrologique et du filet à plancton, tandis que le.

  14. Proteolysis of milk fat globule membrane proteins during in vitro gastric digestion of milk.

    Science.gov (United States)

    Ye, A; Cui, J; Singh, H

    2011-06-01

    The influence of gastric proteolysis on the physicochemical characteristics of milk fat globules and the proteins of the milk fat globule membrane (MFGM) in raw milk and cream was examined in vitro in simulated gastric fluid (SGF) containing various pepsin concentrations at pH 1.6 for up to 2h. Apparent flocculation of the milk fat globules occurred in raw milk samples incubated in SGF containing pepsin, but no coalescence was observed in either raw milk samples or cream samples. The changes in the particle size of the fat globules as a result of the flocculation were dependent on the pepsin concentration. Correspondingly, the physical characteristics of the fat globules and the composition of the MFGM proteins in raw milk changed during incubation in SGF containing pepsin. The major MFGM proteins were hydrolyzed at different rates by the pepsin in the SGF; butyrophilin was more resistant than xanthine oxidase, PAS 6, or PAS 7. Peptides with various molecular weights, which altered with the time of incubation and the pepsin concentration, were present at the surfaces of the fat globules. Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  15. Structural changes of bovine milk fat globules during in vitro digestion.

    Science.gov (United States)

    Gallier, S; Ye, A; Singh, H

    2012-07-01

    An in vitro digestion model that simulated gastric and intestinal fasting conditions was used to monitor the physical, chemical, and structural changes of fat globules from raw bovine milk. During in vitro gastric digestion, the fat globules were stable under low-acidic conditions. Some peptides and β-lactoglobulin were resistant to proteolysis by pepsin. Phospholipids, proteins, and peptides stabilized the globules in the stomach model. During in vitro intestinal digestion, most of the β-lactoglobulin and residual peptides were hydrolyzed by trypsin and chymotrypsin, and the lipolytic products, released from the hydrolysis of the triglyceride core of the globules, led to destabilization and coalescence of the globules. By accumulating at the surface of the fat globules, the lipolytic products formed a lamellar phase and their solubilization by bile salts resulted in the formation of disk-shaped micelles. This study brings new interesting insights on the digestion of bovine milk. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  16. Critical phenomena and polymer coil-to-globule transition

    International Nuclear Information System (INIS)

    Chu, B.; Xu Renliang; Wang Zhulun; Zuo Ju

    1988-01-01

    Small-angle scattering techniques including laser light scattering (LLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) have been useful tools to measure the static and dynamic properties (in terms of critical fluctuations) of fluids, fluid mixtures, polymer and micellar solutions, polymer blends and metallic alloys. A brief review is given of recent results in critical-phenomena experiments using small-angle scattering techniques. Topics of current interest are pointed out, and a guide to the vast literature on critical opalescence is provided. Coil-to-globule transition in polymer solutions has been a classic experimental challenge over the past decade. In order to succeed in reaching the collapsed regime, it becomes important to realize that single coil contraction of a linear polymer molecule in solution takes place in the neighborhood of phase separations. By using the recent development of a small-angle light-scattering spectrometer and by taking advantage of a successful polymer fractionation experiment, the transition behavior of linear polystyrene in cyclohexane from the Θ state to the collapsed regime can be characterized based on both the radius of gyration and the hydrodynamic radius. (orig.)

  17. Effect of foliar nitrogen and sulphur application on aromatic expression of Vitis vinifera L. cv. Sauvignon blanc

    Directory of Open Access Journals (Sweden)

    Florian Lacroux

    2008-09-01

    Significance and impact of the study: Vine nitrogen deficiency can negatively impact on grape aroma potential. Soil nitrogen application can increase vine nitrogen status, but it has several drawbacks: it increases vigour and enhances Botrytis susceptibility. This study shows that foliar N and foliar N + S applications can improve vine nitrogen status and enhance aroma expression in Sauvignon blanc wines without the negative impact on vigour and Botrytis susceptibility. Although this study was carried out on Sauvignon blanc vines, it is likely that foliar N or foliar N + S applications will have similar effects on other grapevine varieties containing volatile thiols (Colombard, Riesling, Petit Manseng and Sémillon.

  18. Geographical origin of Sauvignon Blanc wines predicted by mass spectrometry and metal oxide based electronic nose

    Energy Technology Data Exchange (ETDEWEB)

    Berna, Amalia Z., E-mail: Amalia.Berna@csiro.au [CSIRO Entomology and Food Futures Flagship, PO Box 1700, Canberra, ACT 2601 (Australia); Trowell, Stephen [CSIRO Entomology and Food Futures Flagship, PO Box 1700, Canberra, ACT 2601 (Australia); Clifford, David [CSIRO Mathematical and Information Sciences, Locked Bag 17, North Ryde, NSW 1670 (Australia); Cynkar, Wies; Cozzolino, Daniel [The Australian Wine Research Institute, Waite Road, Urrbrae, PO Box 197, Adelaide, SA 5064 (Australia)

    2009-08-26

    Analysis of 34 Sauvignon Blanc wine samples from three different countries and six regions was performed by gas chromatography-mass spectrometry (GC-MS). Linear discriminant analysis (LDA) showed that there were three distinct clusters or classes of wines with different aroma profiles. Wines from the Loire region in France and Australian wines from Tasmania and Western Australia were found to have similar aroma patterns. New Zealand wines from the Marlborough region as well as the Australian ones from Victoria were grouped together based on the volatile composition. Wines from South Australia region formed one discrete class. Seven analytes, most of them esters, were found to be the relevant chemical compounds that characterized the classes. The grouping information obtained by GC-MS, was used to train metal oxide based electronic (MOS-Enose) and mass spectrometry based electronic (MS-Enose) noses. The combined use of solid phase microextraction (SPME) and ethanol removal prior to MOS-Enose analysis, allowed an average error of prediction of the regional origins of Sauvignon Blanc wines of 6.5% compared to 24% when static headspace (SHS) was employed. For MS-Enose, the misclassification rate was higher probably due to the requirement to delimit the m/z range considered.

  19. Geographical origin of Sauvignon Blanc wines predicted by mass spectrometry and metal oxide based electronic nose

    International Nuclear Information System (INIS)

    Berna, Amalia Z.; Trowell, Stephen; Clifford, David; Cynkar, Wies; Cozzolino, Daniel

    2009-01-01

    Analysis of 34 Sauvignon Blanc wine samples from three different countries and six regions was performed by gas chromatography-mass spectrometry (GC-MS). Linear discriminant analysis (LDA) showed that there were three distinct clusters or classes of wines with different aroma profiles. Wines from the Loire region in France and Australian wines from Tasmania and Western Australia were found to have similar aroma patterns. New Zealand wines from the Marlborough region as well as the Australian ones from Victoria were grouped together based on the volatile composition. Wines from South Australia region formed one discrete class. Seven analytes, most of them esters, were found to be the relevant chemical compounds that characterized the classes. The grouping information obtained by GC-MS, was used to train metal oxide based electronic (MOS-Enose) and mass spectrometry based electronic (MS-Enose) noses. The combined use of solid phase microextraction (SPME) and ethanol removal prior to MOS-Enose analysis, allowed an average error of prediction of the regional origins of Sauvignon Blanc wines of 6.5% compared to 24% when static headspace (SHS) was employed. For MS-Enose, the misclassification rate was higher probably due to the requirement to delimit the m/z range considered.

  20. Multistage unfolding of an SH3 domain: an initial urea-filled dry molten globule precedes a wet molten globule with non-native structure.

    Science.gov (United States)

    Dasgupta, Amrita; Udgaonkar, Jayant B; Das, Payel

    2014-06-19

    The unfolding of the SH3 domain of the PI3 kinase in aqueous urea has been studied using a synergistic experiment-simulation approach. The experimental observation of a transient wet molten globule intermediate, IU, with an unusual non-native burial of the sole Trp residue, W53, provides the benchmark for the unfolding simulations performed (eight in total, each at least 0.5 μs long). The simulations reveal that the partially unfolded IU ensemble is preceded by an early native-like molten globule intermediate ensemble I*. In the very initial stage of unfolding, dry globule conformations with the protein core filled with urea instead of water are transiently observed within the I* ensemble. Water penetration into the urea-filled core of dry globule conformations is frequently accompanied by very transient burial of W53. Later during gradual unfolding, W53 is seen to again become transiently buried in the IU ensemble for a much longer time. In the structurally heterogeneous IU ensemble, conformational flexibility of the C-terminal β-strands enables W53 burial by the formation of non-native, tertiary contacts with hydrophobic residues, which could serve to protect the protein from aggregation during unfolding.

  1. Dry molten globule intermediates and the mechanism of protein unfolding.

    Science.gov (United States)

    Baldwin, Robert L; Frieden, Carl; Rose, George D

    2010-10-01

    New experimental results show that either gain or loss of close packing can be observed as a discrete step in protein folding or unfolding reactions. This finding poses a significant challenge to the conventional two-state model of protein folding. Results of interest involve dry molten globule (DMG) intermediates, an expanded form of the protein that lacks appreciable solvent. When an unfolding protein expands to the DMG state, side chains unlock and gain conformational entropy, while liquid-like van der Waals interactions persist. Four unrelated proteins are now known to form DMGs as the first step of unfolding, suggesting that such an intermediate may well be commonplace in both folding and unfolding. Data from the literature show that peptide amide protons are protected in the DMG, indicating that backbone structure is intact despite loss of side-chain close packing. Other complementary evidence shows that secondary structure formation provides a major source of compaction during folding. In our model, the major free-energy barrier separating unfolded from native states usually occurs during the transition between the unfolded state and the DMG. The absence of close packing at this barrier provides an explanation for why phi-values, derived from a Brønsted-Leffler plot, depend primarily on structure at the mutational site and not on specific side-chain interactions. The conventional two-state folding model breaks down when there are DMG intermediates, a realization that has major implications for future experimental work on the mechanism of protein folding. 2010 Wiley-Liss, Inc.

  2. Protein characterization of Roditis Greek grape variety and Sauvignon blanc and changes in certain nitrogen compounds during alcoholic fermentation

    Directory of Open Access Journals (Sweden)

    Z. G. Nakopoulou

    2006-09-01

    Full Text Available Must and wine samples of the Greek grape variety Roditis and the French one Sauvignon blanc were analysed in order to obtain further knowledge of the protein profile of Roditis and to watch the evolution of grape proteins during the alcoholic fermentation of Roditis and Sauvignon blanc musts. For these purposes protein samples were isolated from must and wine samples by ammonium sulphate precipitation and subjected to sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS - PAGE. Eleven and nine bands with molecular weights between 11,1 and 64,4 kDa were detected on the electrophoregramms of Roditis and Sauvignon blanc must and wine samples respectively, using Coomassie Brillant Blue R-250 and silver staining methods. Two protein fractions of must and wine samples with molecular weights of 64,4 kDa and 34,4 kDa were identified as being glycoproteins in the profile of the Greek grape variety, according to the Periodic acid - silver staining, while only one must and wine fraction of 64,4 kDa had positively react with this stain, as far as it concerns Sauvignon blanc. None of the low molecular weight protein fractions found to be responsible for haze formation. A modified (Bradford dye - binding procedure was used for the determination of musts and wines soluble proteins. Free amino nitrogen and the contents of neutral and acidic polysaccharides in the protein fractions after chromatography on Sephadex G - 25, were also analyzed.

  3. The Effect of Sterilization on Size and Shape of Fat Globules in Model Processed Cheese Samples

    Directory of Open Access Journals (Sweden)

    B. Tremlová

    2006-01-01

    Full Text Available Model cheese samples from 4 independent productions were heat sterilized (117 °C, 20 minutes after the melting process and packing with an aim to prolong their durability. The objective of the study was to assess changes in the size and shape of fat globules due to heat sterilization by using image analysis methods. The study included a selection of suitable methods of preparation mounts, taking microphotographs and making overlays for automatic processing of photographs by image analyser, ascertaining parameters to determine the size and shape of fat globules and statistical analysis of results obtained. The results of the experiment suggest that changes in shape of fat globules due to heat sterilization are not unequivocal. We found that the size of fat globules was significantly increased (p < 0.01 due to heat sterilization (117 °C, 20 min, and the shares of small fat globules (up to 500 μm2, or 100 μm2 in the samples of heat sterilized processed cheese were decreased. The results imply that the image analysis method is very useful when assessing the effect of technological process on the quality of processed cheese quality.

  4. On the correlation between Mont Blanc and Baksan underground detectors in February 1987

    International Nuclear Information System (INIS)

    Chudakov, A.E.

    1989-01-01

    According to the author, there is a correlation directly between the Mont Blanc (LSD) and Baksan data, two quite similar underground scintillation detectors. The idea is: if something really happens that activates the gravitational antennas (G.A.) signal and that, after 1.2 s, gives a signal in a particular scintillator, then there should be a chance to observe a quasi-simultaneous signal in another, possibly very distant scintillator. The big distance between the Baksan and LSD detectors should exclude the common electrical power supply as a possible source of correlation. Another advantage of the suggested search could be a simplicity of statistical analysis when the duration of the signal (in the scintillation counter) is much less than the correlation time interval (1 s). In this report, the author discusses both positive and negative evidence concerning the LSD-Baksan correlation

  5. Globules, dark clouds, and low mass pre-main sequence stars

    International Nuclear Information System (INIS)

    Hyland, A.R.

    1981-01-01

    The current observational and theoretical literature on Bok globules and their relationship to star formation is reviewed. Recent observations of globules at optical, infrared, and far infrared wavelengths are shown to provide important constraints on their structure and evolutionary status, and the suggestion that many globules are gravitationally unstable is seriously questioned. Dark clouds associated with T associations are well-known sites of recent and continuing star formation. In recent years molecular observations and far infrared surveys have provided maps of such regions from which possible sites of star formation may be identified. Optical (Hα) and near infrared surveys have enabled a clear identification of pre-main sequence (PMS) objects within the clouds. Methods of distinguishing these from background objects and the nature of their infrared excesses are examined in the light of recent observations in the near and far infrared. The perennial question as to the existence of anomalous reddening within dark clouds is also investigated. (Auth.)

  6. Using confocal laser scanning microscopy to probe the milk fat globule membrane and associated proteins.

    Science.gov (United States)

    Gallier, Sophie; Gragson, Derek; Jiménez-Flores, Rafael; Everett, David

    2010-04-14

    The bovine milk fat globule membrane (MFGM) is an important, biologically relevant membrane due to its functional and health properties. Its composition has been thoroughly studied, but its structure, especially the lateral organization of its components, still remains unclear. We have used confocal laser scanning microscopy (CLSM) to investigate the surface structure of the MFGM in globules with different degrees of processing using two types of fluorescently labeled phospholipid probes and a protein dye. Using this technique, we have observed heterogeneities in the distribution of MFGM lipids and proteins relating to the processing and size of the globules. The effect of pretreating the milk (centrifugation, pasteurization-homogenization and churning) was studied by double-staining the surface of the milk fat globules, followed by observation using CLSM, and by determining the phospholipid profile of raw milk, raw cream, processed milk and buttermilk powder. Our findings agree with other techniques by showing that the composition of the MFGM changes with processing through the loss of phospholipids and the adsorption of caseins and whey proteins onto the surface.

  7. Solubilization methods and reference 2-DE map of cow milk fat globules.

    Science.gov (United States)

    Bianchi, Laura; Puglia, Michele; Landi, Claudia; Matteoni, Silvia; Perini, Daniele; Armini, Alessandro; Verani, Margherita; Trombetta, Claudia; Soldani, Patrizia; Roncada, Paola; Greppi, Gianfranco; Pallini, Vitaliano; Bini, Luca

    2009-07-21

    Milk fat globules (MFGs) are secretory vesicles assembled and secreted by mammary epithelial cells during lactation. They consist of fat globules surrounded by a lipid bilayer membrane which is derived from the apical membrane of the lactating cells. MFGs contain, besides lipids, proteins from the apical plasma membrane and from the cytoplasmatic material. Their peculiar vesicle nature makes them a suitable and easily available source of biological material in monitoring the physiopathological state of the mammary gland. Unfortunately, the conspicuous lipidic component of MFGs consistently limits protein extraction and purification for MFG proteomic investigations. This work deals with the development of a suitable procedure for protein extraction from the cow MFGs in order to qualitatively and quantitatively improve 2-D electropherograms of the MFG. MFGs were purified from raw milk by centrifugation and then delipidated/precipitated. The resulting protein pellets were solubilised using four different 2-D SDS PAGE compatible lysis buffers. Applied methodological procedures for protein extraction and evaluation of the resulting 2-D protein-pattern are presented and discussed. Using these procedures a reference 2-D map of cow milk fat globules is also reported. The majority of the obtained identifications was represented by proteins involved in lipid synthesis or in fat globule secretion.

  8. Separation of milk fat globules via microfiltration: Effect of diafiltration media and opportunities for stream valorization.

    Science.gov (United States)

    Jukkola, A; Partanen, R; Rojas, O J; Heino, A

    2016-11-01

    Milk fat globule membranes (MFGM) sourced in buttermilk have gained recent interest given their nutritional value and functional properties. However, production of isolated MFGM has been challenging given their size similarity with casein micelles, which limits attempts toward fractionation by size exclusion techniques. Therefore, the hypothesis underpinning this study is that the removal of proteins from cream before butter-making facilitates MFGM isolation. As such, milk fat globules were separated from raw whole milk via microfiltration (1.4-µm pore diameter and 0.005-m 2 filtration surface area) by using 3 diafiltration media; namely, skim milk ultrafiltration permeate, saline, and water. Their effects on the stability of the milk fat globules and protein permeation was elucidated. Whereas a substantial reduction in protein concentration was achieved with all diafiltration media (~90% reduction), water and saline produced negligible membrane fouling with better filtration performance. Moreover, diafiltration with skim milk ultrafiltration permeate exhibited reduced permeate flux. Colloidal stability of the resultant milk decreased with all diafiltration solutions due to changing composition and reduced apparent viscosity. Overall, microfiltration was found to be an efficient method for separation of milk fat globules from whole milk, leading to increased MFGM fragment concentration in buttermilk dry matter, thus making it more suitable for industrial utilization. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  9. Curcumin loaded nano globules for solubility enhancement: preparation, characterization and ex vivo release study.

    Science.gov (United States)

    Kumar, Anil; Ahuja, Alka; Ali, Javed; Baboota, Sanjula

    2012-11-01

    Curcumin in spite of being an effective chemotherapeutic agent against different type of cancer, suffer from the problem of low systemic bioavailability due to low aqueous solubility, extensive intestinal metabolism and first-pass metabolism when administered via the oral route. The aim of present investigation was to evaluate the potential of nano globules based nanoemulsion formulation for the solubility enhancement of curcumin. The nano globules based formulation was developed using Labrafac Lipophile WL 1349, Unitop FFT 40, PEG 400 and distilled water as an oil, surfactant, co-surfactant and aqueous phase respectively using aqueous titration method. Furthermore, different formulations were subjected to physical stability and consequently evaluated for ex vivo permeation using small intestine. The optimized formulation had small average globule diameter of 58 nm with zeta potential of -32 mv which indicated long-term dispersion stability. The globules were spherical in shape as observed by Transmission electron microscopy. During ex vivo study, the release of curcumin from nanoemulsion was 96.21% and 98.1% in 6 h and 12 h respectively whereas CU suspension was release up to 28.2% at the end of 12 h. This indicated the enhancement of solubility of curcumin in aqueous solution which is the rate limiting step in the absorption of curcumin in the intestine.

  10. Globule-size distribution in injectable 20% lipid emulsions: Compliance with USP requirements.

    Science.gov (United States)

    Driscoll, David F

    2007-10-01

    The compliance of injectable 20% lipid emulsions with the globule-size limits in chapter 729 of the U.S. Pharmacopeia (USP) was examined. As established in chapter 729, dynamic light scattering was applied to determine mean droplet diameter (MDD), with an upper limit of 500 nm. Light obscuration was used to determine the size of fat globules found in the large-diameter tail, expressed as the volume-weighted percent fat exceeding 5 microm (PFAT(5)), with an upper limit of 0.05%. Compliance of seven different emulsions, six of which were stored in plastic bags, with USP limits was assessed. To avoid reaching coincidence limits during the application of method II from overly concentrated emulsion samples, a variable dilution scheme was used to optimize the globule-size measurements for each emulsion. One-way analysis of variance of globule-size distribution (GSD) data was conducted if any results of method I or II exceeded the respective upper limits. Most injectable lipid emulsions complied with limits established by USP chapter 729, with the exception of those of one manufacturer, which failed limits as proposed for to meet the PFAT(5) three of the emulsions tested. In contrast, all others studied (one packaged in glass and three packaged in plastic) met both criteria. Among seven injectable lipid emulsions tested for GSD, all met USP chapter 729 MDD requirements and three, all from the same manufacturer and packaged in plastic, did not meet PFAT(5) requirements.

  11. Infrared study of new star cluster candidates associated to dusty globules

    Science.gov (United States)

    Soto King, P.; Barbá, R.; Roman-Lopes, A.; Jaque, M.; Firpo, V.; Nilo, J. L.; Soto, M.; Minniti, D.

    2014-10-01

    We present results from a study of a sample of small star clusters associated to dusty globules and bright-rimmed clouds that have been observed under ESO/Chile public infrared survey Vista Variables in the Vía Láctea (VVV). In this short communication, we analyse the near-infrared properties of a set of four small clusters candidates associated to dark clouds. This sample of clusters associated to dusty globules are selected from the new VVV stellar cluster candidates developed by members of La Serena VVV Group (Barbá et al. 2014). Firstly, we are producing color-color and color-magnitude diagrams for both, cluster candidates and surrounding areas for comparison through PSF photometry. The cluster positions are determined from the morphology on the images and also from the comparison of the observed luminosity function for the cluster candidates and the surrounding star fields. Now, we are working in the procedures to establish the full sample of clusters to be analyzed and methods for subtraction of the star field contamination. These clusters associated to dusty globules are simple laboratories to study the star formation relatively free of the influence of large star-forming regions and populous clusters, and they will be compared with those clusters associated to bright-rimmed globules, which are influenced by the energetic action of nearby O and B massive stars.

  12. Coil–globule transition of a polymer involved in excluded-volume interactions with macromolecules

    International Nuclear Information System (INIS)

    Odagiri, Kenta; Seki, Kazuhiko

    2015-01-01

    Polymers adopt extended coil and compact globule states according to the balance between entropy and interaction energies. The transition of a polymer between an extended coil state and compact globule state can be induced by changing thermodynamic force such as temperature to alter the energy/entropy balance. Previously, this transition was theoretically studied by taking into account the excluded-volume interaction between monomers of a polymer chain using the partition function. For binary mixtures of a long polymer and short polymers, the coil-globule transition can be induced by changing the concentration of the shorter polymers. Here, we investigate the transition caused by short polymers by generalizing the partition function of the long polymer to include the excluded-volume effect of short polymers. The coil-globule transition is studied as a function of the concentration of mixed polymers by systematically varying Flory’s χ-parameters. We show that the transition is caused by the interplay between the excluded-volume interaction and the dispersion state of short polymers in the solvent. We also reveal that the same results can be obtained by combining the mixing entropy and elastic energy if the volume of a long polymer is properly defined

  13. Influence of Fermentation Temperature, Yeast Strain, and Grape Juice on the Aroma Chemistry and Sensory Profile of Sauvignon Blanc Wines.

    Science.gov (United States)

    Deed, Rebecca C; Fedrizzi, Bruno; Gardner, Richard C

    2017-10-11

    Sauvignon blanc wine, balanced by herbaceous and tropical aromas, is fermented at low temperatures (10-15 °C). Anecdotal accounts from winemakers suggest that cold fermentations produce and retain more "fruity" aroma compounds; nonetheless, studies have not confirmed why low temperatures are optimal for Sauvignon blanc. Thirty-two aroma compounds were quantitated from two Marlborough Sauvignon blanc juices fermented at 12.5 and 25 °C, using Saccharomyces cerevisiae strains EC1118, L-1528, M2, and X5. Fourteen compounds were responsible for driving differences in aroma chemistry. The 12.5 °C-fermented wines had lower 3-mercaptohexan-1-ol (3MH) and higher alcohols but increased fruity acetate esters. However, a sensory panel did not find a significant difference between fruitiness in 75% of wine pairs based on fermentation temperature, in spite of chemical differences. For wine pairs with significant differences (25%), the 25 °C-fermented wines were fruitier than the 12.5 °C-fermented wines, with high fruitiness associated with 3MH. We propose that the benefits of low fermentation temperatures are not derived from increased fruitiness but a better balance between fruitiness and greenness. Even so, since 75% of wines showed no significant difference, higher fermentation temperatures could be utilized without detriment, lowering costs for the wine industry.

  14. The effect of milk fat globules on adherence and internalization of Salmonella Enteritidis to HT-29 cells.

    Science.gov (United States)

    Guri, A; Griffiths, M; Khursigara, C M; Corredig, M

    2012-12-01

    Milk fat globules were extracted from bovine and goat milk and incubated with HT-29 human adenocarcinoma cells to assess the attachment and internalization of Salmonella Enteritidis. Because the expression of bacterial adhesins is highly affected by the presence of antibiotic, the attachment was studied with and without antibiotic in the cell growth medium. Although no inhibitory effect of the fat globules was observed in the presence of the antibiotic, milk fat globules significantly inhibited the binding and internalization of Salmonella in medium free of antibiotic. The fat globules from both bovine and goat milk markedly reduced bacterial binding and invasion compared with controls, and the cells treated with goat milk-derived fat globules demonstrated greater protective properties than those derived from bovine milk. The effect of heat treatment on bovine fat globules was also investigated, and it was shown that the fat globules from heated milk had a higher degree of inhibition than those from unheated milk. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  15. Relationship between fat globule size and chemical and fatty acid composition of cow's milk in mid lactation

    Directory of Open Access Journals (Sweden)

    Cosima Scolozzi

    2010-01-01

    Full Text Available The milk in 57 Italian Fresian cows in mid lactation was analysed in order to define the relationship between some qualitative milk parameters and the size of milk fat globules. The study focused on the morphometric evaluation of milk fat globules, chemical parameteres and fatty acid composition of the milk. The results show that a prevalence of milk fat globules with a diameter 6 um was associated (P<0.01 with greater milk yield nad a higher percentage of lactose, non-fat dry matter and ash............

  16. Relationship between fat globule size and chemical and fatty acid composition of cow's milk in mid lactation

    Directory of Open Access Journals (Sweden)

    Mina Martini

    2006-01-01

    Full Text Available The milk in 57 Italian Fresian cows in mid lactation was analysed in order to define the relationship between some qualitative milk parameters and the size of milk fat globules. The study focused on the morphometric evaluation of milk fat globules, chemical parameteres and fatty acid composition of the milk. The results show that a prevalence of milk fat globules with a diameter 6 um was associated (P<0.01 with greater milk yield nad a higher percentage of lactose, non-fat dry matter and ash............

  17. Tirant lo Blanc o la pau no passa pels exèrcits

    Directory of Open Access Journals (Sweden)

    Antònia Carré

    2000-11-01

    Full Text Available Tirant lo Blanc o la pau no passa pels exèrcits és un metatext que té bàsicament dos objectius: 1 permetre, a partir d'una lectura activa i creativa de la novel·la de Joanot Martorell, acostar-se als aspectes cavallerescos de l'Edat Mitjana i aprofundir en el concepte de literatura existent aleshores, basat en la reconstrucció i recreació de textos a través de la manipulació de les obres que formaven part del patrimoni cultural de l'època, i 2 possibilitar, a partir de l'anàlisi d'un dels eixos temàtics principals de la novel·la com és la guerra, la reflexió (telemàtica sobre els valors que fonamenten una societat plural i democràtica a les portes del segle XXI: la sensibilització davant de les injustícies i els abusos de poder, la tolerància, la solidaritat, el respecte pel medi ambient, en definitiva, la valoració de la cultura per la pau.

  18. Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

    Directory of Open Access Journals (Sweden)

    Sekigawa Akio

    2012-09-01

    Full Text Available Abstract Background Axonopathy is critical in the early pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD and dementia with Lewy bodies (DLB. Axonal swellings such as globules and spheroids are a distinct feature of axonopathy and our recent study showed that transgenic (tg mice expressing DLB-linked P123H β-synuclein (P123H βS were characterized by P123H βS-immunoreactive axonal swellings (P123H βS-globules. Therefore, the objectives of this study were to evaluate α-synuclein (αS-immunoreactive axonal swellings (αS-globules in the brains of tg mice expressing human wild-type αS and to compare them with the globules in P123H βS tg mice. Results In αS tg mice, αS-globules were formed in an age-dependent manner in various brain regions, including the thalamus and basal ganglia. These globules were composed of autophagosome-like membranous structures and were reminiscent of P123H βS-globules in P123H βS tg mice. In the αS-globules, frequent clustering and deformation of mitochondria were observed. These changes were associated with oxidative stress, based on staining of nitrated αS and 4-hydroxy-2-nonenal (4-HNE. In accord with the absence of mitochondria in the P123H βS-globules, staining of nitrated αS and 4-HNE in these globules was weaker than that for αS-globules. Leucine-rich repeat kinase 2 (LRRK2, the PARK8 of familial PD, was detected exclusively in αS-globules, suggesting a specific role of this molecule in these globules. Conclusions Lysosomal pathology was similarly observed for both αS- and P123H βS-globules, while oxidative stress was associated with the αS-globules, and to a lesser extent with the P123H βS-globules. Other pathologies, such as mitochondrial alteration and LRRK2 accumulation, were exclusively detected for αS-globules. Collectively, both αS- and P123H βS-globules were formed through similar but distinct pathogenic mechanisms. Our findings suggest that synuclein

  19. A Speculation into the Origin of Neutral Globules In Planetary Nebulae: Could the Helix's Comets Really Be Comets?

    OpenAIRE

    Gussie, Grant

    1995-01-01

    A novel explanation for the origin of the cometary globules within NGC 7293 (the "Helix" planetary nebula) is examined; that these globules originate as massive cometary bodies at large astrocentric radii. The mass of such hypothetical cometary bodies would have to be several orders of magnitude larger than any such bodies observed in our solar system in order to supply the observed mass of neutral gas. It is however shown that comets at "outer Oort cloud" like distances are likely to survive...

  20. A survey of northern Bok globules for H-alpha emission stars

    International Nuclear Information System (INIS)

    Ogura, Katsuo; Hasegawa, Tatsuhiko.

    1983-01-01

    Northern globules in the catalog of Bok and Cordwell (1973) have been surveyed for Hα-emission stars of T Tau type by using the Kiso Schmidt telescope with an objective prism. The results for 15 globules are presented here. A total of 60 emission-line stars, of which 80 % are new, and 17 suspected ones have been discovered. Some of them are known T Tau stars; one star shows Ca 2 H and K lines in emission on objective-prism plates in the blue-violet and presumably is a new T Tau star. The celestial coordinates and rough estimates of magnitude and color are given for all of the objects. (author)

  1. Spitzer Observations of a 24 μm Shadow: Bok Globule CB 190

    Science.gov (United States)

    Stutz, Amelia M.; Bieging, John H.; Rieke, George H.; Shirley, Yancy L.; Balog, Zoltan; Gordon, Karl D.; Green, Elizabeth M.; Keene, Jocelyn; Kelly, Brandon C.; Rubin, Mark; Werner, Michael W.

    2007-08-01

    We present Spitzer observations of the dark globule CB 190 (LDN 771). We observe a roughly circular 24 μm shadow with a 70" radius. The extinction profile of this shadow matches the profile derived from 2MASS photometry at the outer edges of the globule and reaches a maximum of ~32 visual magnitudes at the center. The corresponding mass of CB 190 is ~10 Msolar. Our 12CO and 13CO J=2-1 data over a 10'×10' region centered on the shadow show a temperature ~10 K. The thermal continuum indicates a similar temperature for the dust. The molecular data also show evidence of freezeout onto dust grains. We estimate a distance to CB 190 of 400 pc using the spectroscopic parallax of a star associated with the globule. Bonnor-Ebert fits to the density profile, in conjunction with this distance, yield ξmax=7.2, indicating that CB 190 may be unstable. The high temperature (56 K) of the best-fit Bonnor-Ebert model is in contradiction with the CO and thermal continuum data, leading to the conclusion that the thermal pressure is not enough to prevent free-fall collapse. We also find that the turbulence in the cloud is inadequate to support it. However, the cloud may be supported by the magnetic field, if this field is at the average level for dark globules. Since the magnetic field will eventually leak out through ambipolar diffusion, it is likely that CB 190 is collapsing or in a late precollapse stage. This work is based in part on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract 1407.

  2. Proteomic Analysis of Sauvignon Blanc Grape Skin, Pulp and Seed and Relative Quantification of Pathogenesis-Related Proteins.

    Directory of Open Access Journals (Sweden)

    Bin Tian

    Full Text Available Thaumatin-like proteins (TLPs and chitinases are the main constituents of so-called protein hazes which can form in finished white wine and which is a great concern of winemakers. These soluble pathogenesis-related (PR proteins are extracted from grape berries. However, their distribution in different grape tissues is not well documented. In this study, proteins were first separately extracted from the skin, pulp and seed of Sauvignon Blanc grapes, followed by trypsin digestion and analysis by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS. Proteins identified included 75 proteins from Sauvignon Blanc grape skin, 63 from grape pulp and 35 from grape seed, mostly functionally classified as associated with metabolism and energy. Some were present exclusively in specific grape tissues; for example, proteins involved in photosynthesis were only detected in grape skin and proteins found in alcoholic fermentation were only detected in grape pulp. Moreover, proteins identified in grape seed were less diverse than those identified in grape skin and pulp. TLPs and chitinases were identified in both Sauvignon Blanc grape skin and pulp, but not in the seed. To relatively quantify the PR proteins, the protein extracts of grape tissues were seperated by HPLC first and then analysed by SDS-PAGE. The results showed that the protein fractions eluted at 9.3 min and 19.2 min under the chromatographic conditions of this study confirmed that these corresponded to TLPs and chitinases seperately. Thus, the relative quantification of TLPs and chitinases in protein extracts was carried out by comparing the area of corresponding peaks against the area of a thamautin standard. The results presented in this study clearly demonstrated the distribution of haze-forming PR proteins in grape berries, and the relative quantification of TLPs and chitinases could be applied in fast tracking of changes in PR proteins during grape growth and

  3. The analog of Blanc's law for drift velocities of electrons in gas mixtures in weakly ionized plasma

    International Nuclear Information System (INIS)

    Chiflikian, R.V.

    1995-01-01

    The analog of Blanc's law for drift velocities of electrons in multicomponent gas mixtures in weakly ionized spatially homogeneous low-temperature plasma is derived. The obtained approximate-analytical expressions are valid for average electron energy in the 1--5 eV range typical for plasma conditions of low-pressure direct current (DC) discharges. The accuracy of these formulas is ±5%. The analytical criterion of the negative differential conductivity (NDC) of electrons in binary mixtures of gases is obtained. NDC of electrons is predicted in He:Kr and He:Xe rare gas mixtures. copyright 1995 American Institute of Physics

  4. Llibre Blanc de l’Eurodistricte Català Transfronterer: creació de projecte i reestructuració territorial

    OpenAIRE

    Castañer i Vivas, Margarida

    2011-01-01

    En aquest article, s’hi presenta el procés d’elaboració, la metodologia, les reflexions i les conclusions del Llibre Blanc de l’Eurodistricte Català Transfronterer elaborat per la Mission Opérationnelle Transfrontalière (MOT) i la Universitat de Girona (UdG). L’estudi té per objectiu acompanyar la definició i l’emergència d’un projecte de territori transfronterer basat en la realitat d’un àmbit territorial compartit entre el departament dels Pirineus Orientals i les comarques de la província ...

  5. L'érosion dans les environnements glaciaires : exemple du Glacier des Bossons (Massif du Mont-Blanc, Haute-Savoie, France)

    OpenAIRE

    Godon , Cécile

    2013-01-01

    The study presented in this PhD memory aim at better define and quantify the present timeerosion processes in glacial and proglacial domain. The Glacier des Bossons, situated in theMont-Blanc massif (Haute-Savoie, France), is a good example of a natural and nonanthropizedsystem which allows us to study this topic. This glacier lies on two mainlithologies (the Mont-Blanc granite and the metamorphic bedrock) and this peculiarity is usedto determine the origin of the glacial sediments. The sedim...

  6. Exploration of consumer perception of Sauvignon Blanc wines with enhanced aroma properties using two different descriptive methods.

    Science.gov (United States)

    Lezaeta, Alvaro; Bordeu, Edmundo; Næs, Tormod; Varela, Paula

    2017-09-01

    The aim of this study was to evaluate consumers' perception of a complex set of stimuli as aromatically enriched wines. For that, two consumer based profiling methods were compared, concurrently run with overall liking measurements: projective mapping based on choice or preference (PM-C), a newly proposed method, and check-all-that-apply (CATA) questions with an ideal sample, a more established, consumer-based method for product optimization. Reserve bottling and regular bottling of Sauvignon Blanc wines from three wineries were aromatically enriched with natural aromas collected by condensation during wine fermentation. A total of 144 consumers were enrolled in the study. The results revealed that both consumer-based highlighted the positive effect of aromatic enrichment on consumer perception and acceptance. However, PM-C generated a very detailed description, in which consumers focused less on the sensory aspects and more on the usage, attitudes, and reasons behind their choices. Providing a deeper understanding of the drivers of liking/disliking of enriched Sauvignon Blanc wines. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Structural basis for the appearance of a molten globule state in chimeric molecules derived from lysozyme and alpha-lactalbumin.

    Science.gov (United States)

    Joniau, M; Haezebrouck, P; Noyelle, K; Van Dael, H

    2001-07-01

    The problem as to why alpha-lactalbumin, in the absence of Ca(2+), forms a molten globule intermediate, in contrast to its structural homologue lysozyme, has been addressed by the construction of chimeras of human lysozyme in which either the Ca(2+)-binding loop or a part of helix C of bovine alpha-lactalbumin were transplanted. Previously, we have shown that the introduction of both structural elements together in the lysozyme matrix causes the apo form of the resulting chimera to display molten globule behavior during the course of thermal denaturation. In this article, we demonstrate that this molten globule character is not correlated with the Ca(2+)-binding loop. Also, the Del 101 mutant in which Arg101 was deleted to simulate the alpha-lactalbumin conformation of the connecting loop between helix C and helix D, does not show a stable equilibrium intermediate. Rather, the molten globule character of the chimeras has to be related with a specific part of helix C. More particularly, attention is drawn to the four hydrophobic side-chains I93, V96, I99, and L100, the lysozyme counterparts of which are constituted of less bulky valines and alanine. Our observations are discussed in terms of decreased stability of the native form and increased stability of the intermediate molten globule. Copyright 2001 Wiley-Liss, Inc.

  8. Dietary prebiotics, milk fat globule membrane and lactoferrin affects structural neurodevelopment in the young piglet

    Directory of Open Access Journals (Sweden)

    Austin T Mudd

    2016-02-01

    Full Text Available Introduction: Milk fat globule membrane (MFGM and lactoferrin have been identified as two components that have potential to affect neurodevelopment. While concentrations of some MFGM constituents in infant formulas are within human milk range, they may not be present at optimal or clinically effective levels. However, lactoferrin levels of infant formulas are consistently reported to be lower than human milk. This study sought to provide a novel combination of prebiotics, bovine-derived milk fat globule membrane and lactoferrin and assess their influence on neurodevelopment. Methods: Twenty-four male piglets were provided either TEST (n=12 or CONT (n=12 diet from 2 to 31 d of age. Piglets underwent spatial T-maze assessment starting at 17 d of age, were subjected to magnetic resonance imaging at 30 d of age, and were euthanized for tissue collection at 31 d of age. Results: Diffusion tensor imaging revealed differences in radial (P = 0.032 and mean (P = 0.028 diffusivities in the internal capsule, where CONT piglets had higher rates of diffusion compared with TEST piglets. Voxel-based morphometry indicated larger (P < 0.05 differences in cortical grey and white matter concentrations, with CONT piglets having larger tissue clusters in these regions compared with TEST piglets. In the spatial T-maze assessment, CONT piglets exhibited shorter latency to choice compared with TEST piglets on d 2 of acquisition and d 3 and 4 of reversal. Conclusion: Observed differences in microstructure maturation of the internal capsule and cortical tissue concentrations suggest that piglets provided TEST diet were more advanced developmentally than piglets provided CONT diet. Therefore, supplementation of infant formula with prebiotics, milk fat globule membrane and lactoferrin may support neurodevelopment in human infants.

  9. Lipid globule size in total nutrient admixtures prepared in three-chamber plastic bags.

    Science.gov (United States)

    Driscoll, David F; Thoma, Andrea; Franke, Rolf; Klütsch, Karsten; Nehne, Jörg; Bistrian, Bruce R

    2009-04-01

    The stability of injectable lipid emulsions in three-chamber plastic (3CP) bags, applying the globule-size limits established by United States Pharmacopeia ( USP ) chapter 729, was studied. A total of five premixed total nutrient admixture (TNA) products packaged in 3CP bags from two different lipid manufacturers containing either 20% soybean oil or a mixture of soybean oil and medium-chain-triglyceride oil as injectable lipid emulsions were tested. Two low-osmolarity 3CP bags and three high-osmolarity 3CP bags were studied. All products were tested with the addition of trace elements and multivitamins. All additive conditions (with and without electrolytes) were tested in triplicate at time 0 (immediately after mixing) and at 6, 24, 30, and 48 hours after mixing; the bags were stored at 24-26 degrees C. All additives were equally distributed in each bag for comparative testing, applying both globule sizing methods outlined in USP chapter 729. Of the bags tested, all bags from one manufacturer were coarse emulsions, showing signs of significant growth in the large-diameter tail when mixed as a TNA formulation and failing the limits set by method II of USP chapter 729 from the outset and throughout the study, while the bags from the other manufacturer were fine emulsions and met these limits. Of the bags that failed, significant instability was noted in one series containing additional electrolytes. Injectable lipid emulsions provided in 3CP bags that did not meet the globule-size limits of USP chapter 729 produced coarser TNA formulations than emulsions that met the USP limits.

  10. Amiata donkeys: fat globule characteristics, milk gross composition and fatty acids

    Directory of Open Access Journals (Sweden)

    Mina Martini

    2014-02-01

    Full Text Available Amiata donkeys are a native breed reared in central Italy. Safeguarding native donkey breeds represents an opportunity for the development of marginal areas, especially given that donkey milk is now appearing on the market due to its potential benefits for human health. To date, only a few studies have focused on the characteristics of the milk fat globules (MFGs in the donkey species. The aim of this study was to assess the morphometric characteristics of the fat globules, gross composition and fatty acid classes in milk from Amiata donkeys reared according to the typical farming and feeding systems of the area of origin. Individual milk samples, collected from 28 Amiata donkeys between 90 and 150 days of lactation, showed the following average composition (g/100 mL: 9.47 dry matter, 1.63 protein, 0.78 casein, 0.53 fat, 7.12 lactose, and 0.36 ash. The unsaturated:saturated fatty acids ratio in milk was close to 1. The percentage of short chains was 12.29, and the percentage of long chain fatty acids was 47.64. The donkey MFGs showed an average diameter of 1.92 μm, and a number of 2.18*109/mL. Regarding MFG distribution, 70% of the globules donkey of milk are smaller than 2 μm. In conclusion, the gross composition and fatty acids of Amiata donkey milk showed similarities with milk from other Italian donkey breeds, with the exception of the monounsaturated fatty acid values which were slightly higher. Donkey MFGs had a smaller diameter and were fewer than in the ruminant species.

  11. X-ray microprobe measurements of the chemical compositions of ALH84001 carbonate globules

    International Nuclear Information System (INIS)

    Flynn, G.J.; Sutton, S.R.; Keller, L.P.

    2004-01-01

    We measured minor element contents of carbonate from ALH84001 and report trends in tbe Ca, V, Mn and Sr in carbonate and the associated magnetite bands. McKay et al. suggested that carbonate globules in the ALH84001 meteorite from Mars contained evidence consistent with the development of bacterial life early in the history of Mars. This result provoked an extensive study of the ALH84001 meteorite. More recently Thomas-Keprta et al. have published a study showing that the magnetite associated with carbonate rims are of the size and shape produced by terrestrial bacteria. This paper has revived interest in ALH84001. The typical ALH84001 carbonate globule consists of four regions: a core of Fe-rich carbonate, a thin magnetite-rich band, a rim of Mn-rich carbonate, and another thin magnetite-rich band. Trace element analysis of each of these phases may allow us to address several important questions about these carbonates: (1) The origin of the magnetite-rich bands in the ALH84001 carbonate globules. If the magnetites are derived from the underlying carbonate through thermal decomposition (as proposed by Golden et al.), then we expect to see 'inherited' trace elements in these magnetite bands. (2) The origin of the rim carbonate, by determining whether the carbonate in the core has the same trace elements as the rim carbonates. (3) The age of the rim carbonate. Borg et al. dated the formation of the rim carbonate using the Rb/Sr chronometer. Borg et al. performed their measurements on an aliquot of what they called a high-Rb, low-Sr carbonate separate from the rim. We previously measured the trace element contents of chips from core and rim carbonates from an ALH84001 carbonate globule using an X-Ray Microprobe on Beamline X26A at the National Synchrotron Light Source. These measurements showed the rim carbonate had a very low Rb content, with Sr>>Rb, inconsistent with the ∼5 ppm Rb reported by Borg et al. in the sample they dated by the Rb/Sr chronometer. The large

  12. Saving energy with paint. Coating with ceramic globules; Energie besparen met verf. Coating met keramische bolletjes

    Energy Technology Data Exchange (ETDEWEB)

    Willemse, R. [Coateq Coatings, Haarlem (Netherlands)

    2011-07-01

    The special paint coating of ThermoShield saves energy. The coating consists for 50% of hollow, vacuum ceramic globules. The waterborne damp-open coating with capillary function resists rain water and removes redundant water in case of draught and it reflects sunlight. [Dutch] Met de speciale verfcoating ThermoShield kan energie worden bespaard. De coating bestaat voor 50% uit holle, vacuum getrokken keramische bolletjes. De watergedragen damp-open coating met capillaire werking stoot bij regen water af en voert bij droogte overtollig vocht af en reflecteert zonlicht.

  13. In vivo digestion of bovine milk fat globules: effect of processing and interfacial structural changes. I. Gastric digestion.

    Science.gov (United States)

    Gallier, Sophie; Cui, Jack; Olson, Trent D; Rutherfurd, Shane M; Ye, Aiqian; Moughan, Paul J; Singh, Harjinder

    2013-12-01

    The aim was to study the in vivo gastric digestion of fat globules in bovine cream from raw, pasteurised or pasteurised and homogenised milk. Fasted rats were gavaged once and chyme samples were collected after 30, 120 and 180 min post-gavage. Proteins from raw (RC) and pasteurised (PC) creams appeared to be digested faster and to a greater extent. Free fatty acids (FAs) increased throughout the 3h postprandial period. Short and medium chain FAs were released more rapidly than long chain FAs which were hydrolysed to a greater degree from PC. The size of the fat globules of all creams increased in the stomach. Protein aggregates were observed in pasteurised and homogenised cream chyme. Protrusions, probably caused by the accumulation of insoluble lipolytic products, appeared at the surface of the globules in RC and PC chyme. Overall, PC proteins and lipids appeared to be digested to a greater extent. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Influence of the oil globule fraction on the release rate profiles from multiple W/O/W emulsions.

    Science.gov (United States)

    Bonnet, Marie; Cansell, Maud; Placin, Frédéric; Monteil, Julien; Anton, Marc; Leal-Calderon, Fernando

    2010-06-15

    Water-in-oil-in-water (W/O/W) double emulsions were prepared and the kinetics of release of magnesium ions from the internal to the external water phase was investigated as a function of the formulation and the globule volume fraction. All the emulsions were formulated using the same surface-active species (polyglycerol polyricinoleate and sodium caseinate). Also, the internal droplet and oil globule diameters were almost identical for all the systems. Two types of W/O/W emulsions were prepared based either on a synthetic oil (miglyol) or on an edible oil (olive oil). The globule volume fraction varied from 11% to 72%. At constant temperature (T=25 degrees C) and irrespective of the oil type, the percentage of magnesium released was lowered by increasing the globule fraction. In all cases, magnesium leakage occurred without film rupturing (no coalescence). Thus, the experimental data were interpreted within the frame of a model based on diffusion. The rate of release was determined by the permeation coefficient of magnesium across the oil phase and by the binding (chelation) of magnesium by caseinate molecules. The data could be adequately fitted by considering a time-dependant permeation coefficient. The better retention of magnesium at high globule fractions could account for two distinct phenomena: (i) the reduction of the relative volume of the outer phase, and (ii) the attenuation of the permeation coefficient over time induced by interfacial magnesium binding, all the more important than the globule fraction increased. Copyright 2010 Elsevier B.V. All rights reserved.

  15. LOOKING INTO THE HEARTS OF BOK GLOBULES: MILLIMETER AND SUBMILLIMETER CONTINUUM IMAGES OF ISOLATED STAR-FORMING CORES

    International Nuclear Information System (INIS)

    Launhardt, R.; Henning, Th.; Khanzadyan, T.; Schmalzl, M.; Wolf, S.; Nutter, D.; Ward-Thompson, D.; Bourke, T. L.; Zylka, R.

    2010-01-01

    We present the results of a comprehensive infrared, submillimeter, and millimeter continuum emission study of isolated low-mass star-forming cores in 32 Bok globules, with the aim to investigate the process of star formation in these regions. The submillimeter and millimeter dust continuum emission maps together with the spectral energy distributions are used to model and derive the physical properties of the star-forming cores, such as luminosities, sizes, masses, densities, etc. Comparisons with ground-based near-infrared and space-based mid- and far-infrared images from Spitzer are used to reveal the stellar content of the Bok globules, association of embedded young stellar objects (YSOs) with the submillimeter dust cores, and the evolutionary stages of the individual sources. Submillimeter dust continuum emission was detected in 26 out of the 32 globule cores observed. For 18 globules with detected (sub)millimeter cores, we derive evolutionary stages and physical parameters of the embedded sources. We identify nine starless cores, most of which are presumably prestellar, nine Class 0 protostars, and twelve Class I YSOs. Specific source properties like bolometric temperature, core size, and central densities are discussed as a function of evolutionary stage. We find that at least two thirds (16 out of 24) of the star-forming globules studied here show evidence of forming multiple stars on scales between 1000 and 50,000 AU. However, we also find that most of these small prototstar and star groups are comprised of sources with different evolutionary stages, suggesting a picture of slow and sequential star formation in isolated globules.

  16. The influence of casein haplotype on morphometric characteristics of fat globules and fatty acid composition of milk in Italian Holstein cows.

    Science.gov (United States)

    Perna, Annamaria; Intaglietta, Immacolata; Simonetti, Amalia; Gambacorta, Emilio

    2016-04-01

    The aim of this work was to investigate the effect of casein haplotypes (αS1-, β-, and κ-caseins) on morphometric characteristics of fat globules and fatty acid composition of Italian Holstein milk. Casein haplotypes were determined by isoelectric focusing; milk fat globule size was measured by using a fluorescence microscope; and fatty acid profile was determined by gas chromatography. Casein haplotype significantly affected the fat globule size, the percentage incidence of each globule size class on total measured milk fat globules, and fatty acid composition. A higher incidence of smaller milk fat globules was associated with the BB-A(2)A(2)-BB genotype (αS1-, β-, and κ-casein haplotypes, respectively), whereas small globules were not detected in BB-A(2)A(1)-AA milk, but that milk had the highest percentage of large globules. A higher content of monounsaturated fatty acids was associated with the BB-A(2)A(2)-AB genotype, whereas higher contents of conjugated linoleic acid and docosahexaenoic acid were detected in BB-A(1)A(1)-AA milk. Our results indicate that casein haplotype could affect fat characteristics and, therefore, the nutritional and technological quality of milk. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  17. Data from proteomic characterization and comparison of mammalian milk fat globule proteomes by iTRAQ analysis

    Directory of Open Access Journals (Sweden)

    Yongxin Yang

    2015-06-01

    Full Text Available Milk fat globules memebrane (MFGM-enriched proteomes from Holstein, Jersey, yak, buffalo, goat, camel, horse, and human were extracted and identified by an iTRAQ quantification proteomic approach. Proteomes data were analyzed by bioinformatic and multivariate statistical analysis and used to present the characteristic traits of the MFGM proteins among the studied mammals. The data of this study are also related to the research article “Proteomic characterization and comparison of mammalian milk fat globule proteomes by iTRAQ analysis” in the Journal of Proteomics [1].

  18. Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites*

    Science.gov (United States)

    Honaker, Matthew T.; Acchione, Mauro; Zhang, Wei; Mannervik, Bengt; Atkins, William M.

    2013-01-01

    The role of conformational ensembles in enzymatic reactions remains unclear. Discussion concerning “induced fit” versus “conformational selection” has, however, ignored detoxication enzymes, which exhibit catalytic promiscuity. These enzymes dominate drug metabolism and determine drug-drug interactions. The detoxication enzyme glutathione transferase A1–1 (GSTA1–1), exploits a molten globule-like active site to achieve remarkable catalytic promiscuity wherein the substrate-free conformational ensemble is broad with barrierless transitions between states. A quantitative index of catalytic promiscuity is used to compare engineered variants of GSTA1–1 and the catalytic promiscuity correlates strongly with characteristics of the thermodynamic partition function, for the substrate-free enzymes. Access to chemically disparate transition states is encoded by the substrate-free conformational ensemble. Pre-steady state catalytic data confirm an extension of the conformational selection model, wherein different substrates select different starting conformations. The kinetic liability of the conformational breadth is minimized by a smooth landscape. We propose that “local” molten globule behavior optimizes detoxication enzymes. PMID:23649628

  19. On the location of the surface-attached globule phase in collapsing polymers

    International Nuclear Information System (INIS)

    Owczarek, A L; Rechnitzer, A; Krawczyk, J; Prellberg, T

    2007-01-01

    We investigate the existence and location of the surface phase known as the 'surface-attached globule' (SAG) conjectured previously to exist in lattice models of three-dimensional polymers when they are attached to a wall that has a short-range potential. The bulk phase, where the attractive intra-polymer interactions are strong enough to cause a collapse of the polymer into a liquid-like globule and the wall either has weak attractive or repulsive interactions, is usually denoted desorbed-collapsed or DC. Recently, this DC phase was conjectured to harbour two surface phases separated by a boundary where the bulk free energy is analytic while the surface free energy is singular. The surface phase for more attractive values of the wall interaction is the SAG phase. We discuss in more detail the properties of this proposed surface phase and provide Monte Carlo evidence for self-avoiding walks up to a length 256 that this surface phase most likely does exist. Importantly, we discuss alternatives for the surface phase boundary. In particular, we conclude that this boundary may lie along the zero wall interaction line and the bulk phase boundaries rather than any new phase boundary curve

  20. On the location of the surface-attached globule phase in collapsing polymers

    Energy Technology Data Exchange (ETDEWEB)

    Owczarek, A L [Department of Mathematics and Statistics, University of Melbourne, Victoria 3010 (Australia); Rechnitzer, A [Department of Mathematics, University of British Columbia, BC V6T-1Z2 (Canada); Krawczyk, J [Department of Mathematics and Statistics, University of Melbourne, Victoria 3010 (Australia); Prellberg, T [School of Mathematical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS (United Kingdom)

    2007-11-02

    We investigate the existence and location of the surface phase known as the 'surface-attached globule' (SAG) conjectured previously to exist in lattice models of three-dimensional polymers when they are attached to a wall that has a short-range potential. The bulk phase, where the attractive intra-polymer interactions are strong enough to cause a collapse of the polymer into a liquid-like globule and the wall either has weak attractive or repulsive interactions, is usually denoted desorbed-collapsed or DC. Recently, this DC phase was conjectured to harbour two surface phases separated by a boundary where the bulk free energy is analytic while the surface free energy is singular. The surface phase for more attractive values of the wall interaction is the SAG phase. We discuss in more detail the properties of this proposed surface phase and provide Monte Carlo evidence for self-avoiding walks up to a length 256 that this surface phase most likely does exist. Importantly, we discuss alternatives for the surface phase boundary. In particular, we conclude that this boundary may lie along the zero wall interaction line and the bulk phase boundaries rather than any new phase boundary curve.

  1. Test of Blanc's law for negative ion mobility in mixtures of SF6 with N2, O2 and air

    International Nuclear Information System (INIS)

    Hinojosa, G; Urquijo, J de

    2003-01-01

    We have measured the mobility of negative ion species drifting in mixtures of SF 6 with N 2 , O 2 and air. The pulsed Townsend experiment was used for this purpose. The conditions of the experiment, high pressures and low values of the reduced electric field, E/N, ensured that the majority species drifting in the gap was SF 6 - , to which the present mobilities are ascribed. The extrapolated, zero field mobilities for several mixture compositions were used to test them successfully with Blanc's law. Moreover, the measured zero field SF 6 - mobilities in air could also be explained in terms of the measured mobilities for this ionic species in N 2 and O 2

  2. Effect of homogenization and heat treatment on the behavior of protein and fat globules during gastric digestion of milk.

    Science.gov (United States)

    Ye, Aiqian; Cui, Jian; Dalgleish, Douglas; Singh, Harjinder

    2017-01-01

    The effects of homogenization and heat treatment on the formation and the breakdown of clots during gastric digestion of whole milk were investigated using a human gastric simulator. Homogenization and heat treatment led to formation of coagula with fragmented and crumbled structures compared with the coagulum formed from raw whole milk, but a larger fraction of the protein and more fat globules were incorporated into the coagula induced by action of the milk-clotting enzyme pepsin. The fat globules in the whole milk appeared to be embedded in the clots as they formed. After formation of the clot, the greater numbers of pores in the structures of the clots formed with homogenized milk and heated whole milk led to greater rates of protein hydrolysis by pepsin, which resulted in faster release of fat globules from the clots into the digesta. Coalescence of fat globules occurred both in the digesta and within the protein clots no matter whether they were in homogenized or heated milk samples. The formation of clots with different structures and hence the changes in the rates of protein hydrolysis and the release of milk fat into the digesta in the stomach provide important information for understanding the gastric emptying of milk and the potential to use this knowledge to manipulate the bioavailability of fat and other fat-soluble nutrients in dairy products. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  3. Stability of milk fat globule membrane proteins toward human enzymatic gastrointestinal digestion.

    Science.gov (United States)

    Le, T T; Van de Wiele, T; Do, T N H; Debyser, G; Struijs, K; Devreese, B; Dewettinck, K; Van Camp, J

    2012-05-01

    The milk fat globule membrane (MFGM) fraction refers to the thin film of polar lipids and membrane proteins that surrounds fat globules in milk. It is its unique biochemical composition that renders MFGM with some beneficial biological activities, such as anti-adhesive effects toward pathogens. However, a prerequisite for the putative bioactivity of MFGM is its stability during gastrointestinal digestion. We, therefore, subjected MFGM material, isolated from raw milk, to an in vitro enzymatic gastrointestinal digestion. Sodium dodecyl sulfate PAGE, in combination with 2 staining methods, Coomassie Blue and periodic acid Schiff staining, was used to evaluate polypeptide patterns of the digest, whereas mass spectrometry was used to confirm the presence of specific MFGM proteins. Generally, it was observed that glycoproteins showed higher resistance to endogenous proteases compared with non-glycosylated proteins. Mucin 1 displayed the highest resistance to digestion and a considerable part of this protein was still detected at its original molecular weight after gastric and small intestine digestion. Cluster of differentiation 36 was also quite resistant to pepsin. A significant part of periodic acid Schiff 6/7 survived the gastric digestion, provided that the lipid moiety was not removed from the MFGM material. Overall, MFGM glycoproteins are generally more resistant to gastrointestinal digestion than serum milk proteins and the presence of lipids, besides glycosylation, may protect MFGM glycoproteins from gastrointestinal digestion. This gastrointestinal stability makes MFGM glycoproteins amenable to further studies in which their putative health-promoting effects can be explored. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  4. Sequence charge decoration dictates coil-globule transition in intrinsically disordered proteins.

    Science.gov (United States)

    Firman, Taylor; Ghosh, Kingshuk

    2018-03-28

    We present an analytical theory to compute conformations of heteropolymers-applicable to describe disordered proteins-as a function of temperature and charge sequence. The theory describes coil-globule transition for a given protein sequence when temperature is varied and has been benchmarked against the all-atom Monte Carlo simulation (using CAMPARI) of intrinsically disordered proteins (IDPs). In addition, the model quantitatively shows how subtle alterations of charge placement in the primary sequence-while maintaining the same charge composition-can lead to significant changes in conformation, even as drastic as a coil (swelled above a purely random coil) to globule (collapsed below a random coil) and vice versa. The theory provides insights on how to control (enhance or suppress) these changes by tuning the temperature (or solution condition) and charge decoration. As an application, we predict the distribution of conformations (at room temperature) of all naturally occurring IDPs in the DisProt database and notice significant size variation even among IDPs with a similar composition of positive and negative charges. Based on this, we provide a new diagram-of-states delineating the sequence-conformation relation for proteins in the DisProt database. Next, we study the effect of post-translational modification, e.g., phosphorylation, on IDP conformations. Modifications as little as two-site phosphorylation can significantly alter the size of an IDP with everything else being constant (temperature, salt concentration, etc.). However, not all possible modification sites have the same effect on protein conformations; there are certain "hot spots" that can cause maximal change in conformation. The location of these "hot spots" in the parent sequence can readily be identified by using a sequence charge decoration metric originally introduced by Sawle and Ghosh. The ability of our model to predict conformations (both expanded and collapsed states) of IDPs at a high

  5. Theoretical study of solvent effects on the coil-globule transition

    Science.gov (United States)

    Polson, James M.; Opps, Sheldon B.; Abou Risk, Nicholas

    2009-06-01

    The coil-globule transition of a polymer in a solvent has been studied using Monte Carlo simulations of a single chain subject to intramolecular interactions as well as a solvent-mediated effective potential. This solvation potential was calculated using several different theoretical approaches for two simple polymer/solvent models, each employing hard-sphere chains and hard-sphere solvent particles as well as attractive square-well potentials between some interaction sites. For each model, collapse is driven by variation in a parameter which changes the energy mismatch between monomers and solvent particles. The solvation potentials were calculated using two fundamentally different methodologies, each designed to predict the conformational behavior of polymers in solution: (1) the polymer reference interaction site model (PRISM) theory and (2) a many-body solvation potential (MBSP) based on scaled particle theory introduced by Grayce [J. Chem. Phys. 106, 5171 (1997)]. For the PRISM calculations, two well-studied solvation monomer-monomer pair potentials were employed, each distinguished by the closure relation used in its derivation: (i) a hypernetted-chain (HNC)-type potential and (ii) a Percus-Yevick (PY)-type potential. The theoretical predictions were each compared to results obtained from explicit-solvent discontinuous molecular dynamics simulations on the same polymer/solvent model systems [J. Chem. Phys. 125, 194904 (2006)]. In each case, the variation in the coil-globule transition properties with solvent density is mostly qualitatively correct, though the quantitative agreement between the theory and prediction is typically poor. The HNC-type potential yields results that are more qualitatively consistent with simulation. The conformational behavior of the polymer upon collapse predicted by the MBSP approach is quantitatively correct for low and moderate solvent densities but is increasingly less accurate for higher densities. At high solvent densities

  6. Differential role of molten globule and protein folding in distinguishing unique features of botulinum neurotoxin.

    Science.gov (United States)

    Kumar, Raj; Kukreja, Roshan V; Cai, Shuowei; Singh, Bal R

    2014-06-01

    Botulinum neurotoxins (BoNTs) are proteins of great interest not only because of their extreme toxicity but also paradoxically for their therapeutic applications. All the known serotypes (A-G) have varying degrees of longevity and potency inside the neuronal cell. Differential chemical modifications such as phosphorylation and ubiquitination have been suggested as possible mechanisms for their longevity, but the molecular basis of the longevity remains unclear. Since the endopeptidase domain (light chain; LC) of toxin apparently survives inside the neuronal cells for months, it is important to examine the structural features of this domain to understand its resistance to intracellular degradation. Published crystal structures (both botulinum neurotoxins and endopeptidase domain) have not provided adequate explanation for the intracellular longevity of the domain. Structural features obtained from spectroscopic analysis of LCA and LCB were similar, and a PRIME (PReImminent Molten Globule Enzyme) conformation appears to be responsible for their optimal enzymatic activity at 37°C. LCE, on the other hand, was although optimally active at 37°C, but its active conformation differed from the PRIME conformation of LCA and LCB. This study establishes and confirms our earlier finding that an optimally active conformation of these proteins in the form of PRIME exists for the most poisonous poison, botulinum neurotoxin. There are substantial variations in the structural and functional characteristics of these active molten globule related structures among the three BoNT endopeptidases examined. These differential conformations of LCs are important in understanding the fundamental structural features of proteins, and their possible connection to intracellular longevity could provide significant clues for devising new countermeasures and effective therapeutics. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats.

    Science.gov (United States)

    Snow, Dallin R; Jimenez-Flores, Rafael; Ward, Robert E; Cambell, Jesse; Young, Michael J; Nemere, Ilka; Hintze, Korry J

    2010-02-24

    Milk fat globule membrane (MFGM) is a biopolymer composed primarily of membrane proteins and lipids that surround the fat globules in milk. Although it is considered to have potential as a bioactive ingredient, few feeding studies have been conducted to measure its potential benefits. The aim of this investigation was to determine if dietary MFGM confers protection against colon carcinogenesis compared to diets containing corn oil (CO) or anhydrous milk fat (AMF). Male, weanling Fischer-344 rats were randomly assigned to one of three dietary treatments that differed only in the fat source: (1) AIN-76A diet, corn oil; (2) AIN-76A diet, AMF; and (3) AIN-76A diet, 50% MFGM, 50% AMF. Each diet contained 50 g/kg diet of fat. With the exception of the fat source, diets were formulated to be identical in macro and micro nutrient content. Animals were injected with 1,2-dimethylhydrazine once per week at weeks 3 and 4, and fed experimental diets for a total of 13 weeks. Over the course of the study dietary treatment did not affect food consumption, weight gain or body composition. After 13 weeks animals were sacrificed, colons were removed and aberrant crypt foci (ACF) were counted by microscopy. Rats fed the MFGM diet (n = 16) had significantly fewer ACF (20.9 +/- 5.7) compared to rats fed corn oil (n = 17) or AMF (n = 16) diets (31.3 +/- 9.5 and 29.8 +/- 11.4 respectively; P < 0.05). Gene expression analysis of colonic mucosa did not reveal differential expression of candidate colon cancer genes, and the sphingolipid profile of the colonic mucosa was not affected by diet. While there were notable and significant differences in plasma and red blood cell lipids, there was no relationship to the cancer protection. These results support previous findings that dietary sphingolipids are protective against colon carcinogenesis yet extend this finding to MFGM, a milk fat fraction available as a food ingredient.

  8. Sequence charge decoration dictates coil-globule transition in intrinsically disordered proteins

    Science.gov (United States)

    Firman, Taylor; Ghosh, Kingshuk

    2018-03-01

    We present an analytical theory to compute conformations of heteropolymers—applicable to describe disordered proteins—as a function of temperature and charge sequence. The theory describes coil-globule transition for a given protein sequence when temperature is varied and has been benchmarked against the all-atom Monte Carlo simulation (using CAMPARI) of intrinsically disordered proteins (IDPs). In addition, the model quantitatively shows how subtle alterations of charge placement in the primary sequence—while maintaining the same charge composition—can lead to significant changes in conformation, even as drastic as a coil (swelled above a purely random coil) to globule (collapsed below a random coil) and vice versa. The theory provides insights on how to control (enhance or suppress) these changes by tuning the temperature (or solution condition) and charge decoration. As an application, we predict the distribution of conformations (at room temperature) of all naturally occurring IDPs in the DisProt database and notice significant size variation even among IDPs with a similar composition of positive and negative charges. Based on this, we provide a new diagram-of-states delineating the sequence-conformation relation for proteins in the DisProt database. Next, we study the effect of post-translational modification, e.g., phosphorylation, on IDP conformations. Modifications as little as two-site phosphorylation can significantly alter the size of an IDP with everything else being constant (temperature, salt concentration, etc.). However, not all possible modification sites have the same effect on protein conformations; there are certain "hot spots" that can cause maximal change in conformation. The location of these "hot spots" in the parent sequence can readily be identified by using a sequence charge decoration metric originally introduced by Sawle and Ghosh. The ability of our model to predict conformations (both expanded and collapsed states) of IDPs at

  9. The effect of milk processing on the microstructure of the milk fat globule and rennet induced gel observed using confocal laser scanning microscopy.

    Science.gov (United States)

    Ong, L; Dagastine, R R; Kentish, S E; Gras, S L

    2010-04-01

    Confocal laser scanning microscopy (CLSM) was successfully used to observe the effect of milk processing on the size and the morphology of the milk fat globule in raw milk, raw ultrafiltered milk, and standardized and pasteurized milk prepared for cheese manufacture (cheese-milk) and commercial pasteurized and homogenized milk. Fat globule size distributions for the milk preparations were analyzed using both image analysis and light scattering and both measurements produced similar data trends. Changes to the native milk fat globule membrane (MFGM) were tracked using a MFGM specific fluorescent stain that allowed MFGM proteins and adsorbed proteins to be differentiated on the fat globule surface. Sodium dodecyl sulfate polyacrylamide gel electrophoresis confirmed the identity of native MFGM proteins isolated from the surface of fat globules within raw, UF retentate, and cheese-milk preparations, whereas only casein was detected on the surface of fat globules in homogenized milk. The microstructure, porosity, and gel strength of the rennet induced gel made from raw milk and cheese-milk was also found to be comparable and significantly different to that made from homogenized milk. Our results highlight the potential use of CLSM as a tool to observe the structural details of the fat globule and associated membrane close to its native environment.

  10. Pre-Carboniferous sedimentary sequences of the northeastern flank of the Parana basin and southwestern of the Parnaiba basin and its uraniferous possibilites

    International Nuclear Information System (INIS)

    Andrade, S.M. de; Camarco, P.E.N.

    1982-01-01

    The analyses of the already existent geological data of the northeastern flank of the Parana Basin and the Southwestern flank of the Parnaiba Basin, added to new data from drilling and geological mapping allowed a better knowledge of the stratigraphy of the pre-carboniferous sedimentary sequences (silurian and devonian ages) as well as provided subsidies for the definition of its uranium possibilites. Besides the already known uranium deposits of the Ponta Grossa Formation, is should be considered as worth while of prospecting the Pimenteiras Formation. (Author) [pt

  11. Calculation of electron transport in Ar/N2 and He/Kr gas mixtures emdash implications for validity of the Blanc close-quote s law method

    International Nuclear Information System (INIS)

    Wang, Y.; Van Brunt, R.J.

    1997-01-01

    The electron drift velocities and corresponding mean energies have been calculated numerically using an approximate two-term solution of the Boltzmann transport equation for Ar/N 2 gas mixtures at electric field-to-gas density ratios (E/N) below 2.0x10 -20 Vm 2 (20 Td) and for He/Kr mixtures at E/N below 5.0x10 -21 Vm 2 (5.0 Td). The results are compared with predictions obtained from a method proposed by Chiflikian based on an open-quotes analog of Blanc close-quote s lawclose quotes [Phys. Plasmas 2, 3902 (1995)]. Large differences are found between the results derived from the Blanc close-quote s law method and those found here from solutions of the transport equation that indicate serious errors and limitations associated with use of the Blanc close-quote s law method to compute drift velocities in gas mixtures. copyright 1997 American Institute of Physics

  12. Globules and pillars in Cygnus X. I. Herschel far-infrared imaging of the Cygnus OB2 environment

    Science.gov (United States)

    Schneider, N.; Bontemps, S.; Motte, F.; Blazere, A.; André, Ph.; Anderson, L. D.; Arzoumanian, D.; Comerón, F.; Didelon, P.; Di Francesco, J.; Duarte-Cabral, A.; Guarcello, M. G.; Hennemann, M.; Hill, T.; Könyves, V.; Marston, A.; Minier, V.; Rygl, K. L. J.; Röllig, M.; Roy, A.; Spinoglio, L.; Tremblin, P.; White, G. J.; Wright, N. J.

    2016-06-01

    The radiative feedback of massive stars on molecular clouds creates pillars, globules and other features at the interface between the H II region and molecular cloud. Optical and near-infrared observations from the ground as well as with the Hubble or Spitzer satellites have revealed numerous examples of such cloud structures. We present here Herschel far-infrared observations between 70 μm and 500 μm of the immediate environment of the rich Cygnus OB2 association, performed within the Herschel imaging survey of OB Young Stellar objects (HOBYS) program. All of the observed irradiated structures were detected based on their appearance at 70 μm, and have been classified as pillars, globules, evaporating gasous globules (EGGs), proplyd-like objects, and condensations. From the 70 μm and 160 μm flux maps, we derive the local far-ultraviolet (FUV) field on the photon dominated surfaces. In parallel, we use a census of the O-stars to estimate the overall FUV-field, that is 103-104 G0 (Habing field) close to the central OB cluster (within 10 pc) and decreases down to a few tens G0, in a distance of 50 pc. From a spectral energy distribution (SED) fit to the four longest Herschel wavelengths, we determine column density and temperature maps and derive masses, volume densities and surface densities for these structures. We find that the morphological classification corresponds to distinct physical properties. Pillars and globules are massive (~500 M⊙) and large (equivalent radius r ~ 0.6 pc) structures, corresponding to what is defined as "clumps" for molecular clouds. EGGs and proplyd-likeobjects are smaller (r ~ 0.1 and 0.2 pc) and less massive (~10 and ~30 M⊙). Cloud condensations are small (~0.1 pc), have an average mass of 35 M⊙, are dense (~6 × 104 cm-3), and can thus be described as molecular cloud "cores". All pillars and globules are oriented toward the Cyg OB2 association center and have the longest estimated photoevaporation lifetimes, a few million

  13. Evolution of hut access facing glacier shrinkage in the Mer de Glace basin (Mont Blanc massif, France)

    Science.gov (United States)

    Mourey, Jacques; Ravanel, Ludovic

    2016-04-01

    Given the evolution of high mountain environment due to global warming, mountaineering routes and huts accesses are more and more strongly affected by glacial shrinkage and concomitant gravity processes, but almost no studies have been conducted on this relationship. The aim of this research is to describe and explain the evolution over the last century of the access to the five alpine huts around the Mer de Glace glacier (Mont Blanc massif), the larger French glacier (length = 11.5 km, area = 30 km²), a major place for Alpine tourism since 1741 and the birthplace of mountaineering, by using several methods (comparing photographs, surveying, collecting historical documents). While most of the 20th century shows no marked changes, loss of ice thickness and associated erosion of lateral moraines generate numerous and significant changes since the 1990s. Boulder falls, rockfalls and landslides are the main geomorphological processes that affect the access, while the glacier surface lowering makes access much longer and more unstable. The danger is then greatly increased and the access must be relocated and/or equipped more and more frequently (e.g. a total of 520 m of ladders has been added). This questions the future accessibility to the huts, jeopardizing an important part of mountaineering and its linked economy in the Mer de Glace area.

  14. Dynamic study of yeast species and Saccharomyces cerevisiae strains during the spontaneous fermentations of Muscat blanc in Jingyang, China.

    Science.gov (United States)

    Wang, Chunxiao; Liu, Yanlin

    2013-04-01

    The evolution of yeast species and Saccharomyces cerevisiae genotypes during spontaneous fermentations of Muscat blanc planted in 1957 in Jingyang region of China was followed in this study. Using a combination of colony morphology on Wallerstein Nutrient (WLN) medium, sequence analysis of the 26S rDNA D1/D2 domain and 5.8S-ITS-RFLP analysis, a total of 686 isolates were identified at the species level. The six species identified were S. cerevisiae, Hanseniaspora uvarum, Hanseniaspora opuntiae, Issatchenkia terricola, Pichia kudriavzevii (Issatchenkia orientalis) and Trichosporon coremiiforme. This is the first report of T. coremiiforme as an inhabitant of grape must. Three new colony morphologies on WLN medium and one new 5.8S-ITS-RFLP profile are described. Species of non-Saccharomyces, predominantly H. opuntiae, were found in early stages of fermentation. Subsequently, S. cerevisiae prevailed followed by large numbers of P. kudriavzevii that dominated at the end of fermentations. Six native genotypes of S. cerevisiae were determined by interdelta sequence analysis. Genotypes III and IV were predominant. As a first step in exploring untapped yeast resources of the region, this study is important for monitoring the yeast ecology in native fermentations and screening indigenous yeasts that will produce wines with regional characteristics. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Clonal differences and impact of defoliation on Sauvignon blanc (Vitis vinifera L.) wines: a chemical and sensory investigation.

    Science.gov (United States)

    Šuklje, Katja; Antalick, Guillaume; Buica, Astrid; Langlois, Jennifer; Coetzee, Zelmari A; Gouot, Julia; Schmidtke, Leigh M; Deloire, Alain

    2016-02-01

    The aim of this study, performed on Sauvignon blanc clones SB11 and SB316, grafted on the same rootstock 101-14 Mgt (Vitis riparia × V. ruperstris) and grown at two adjacent vineyards, was two-fold: (1) to study wine chemical and sensory composition of both clones within an unaltered canopy; and (2) to determine the effect of defoliation (e.g. bunch microclimate) on wine chemical and sensory composition. Orthogonal projection to latent structures discriminate analysis (OPLS-DA) was applied to the concentration profiles of volatile compounds derived from gas chromatography-mass spectrometry data. The loadings directions inferred that 3-isobutyl-2-methoxypyrazine (IBMP) discriminated control treatments (shaded fruit zone) of both clones from defoliation treatments (exposed fruit zone), whereas 3-sulfanyl-hexan-1-ol (3SH), 3-sulfanylhexyl acetate (3SHA), hexanol, hexyl hexanoate and some other esters discriminated defoliated treatments from the controls. The OPLS-DA indicated the importance of IBMP, higher alcohol acetates and phenylethyl esters, for discrimination of clone SB11 from clone SB316 irrespective of the treatment. Defoliation in the fruit zone significantly decreased perceived greenness in clone SB11 and elevated fruitier aromas, whereas in clone SB316 the effect of defoliation on wine sensory perception was less noticeable regardless the decrease in IBMP concentrations. These findings highlight the importance of clone selection and bunch microclimate to diversify produced wine styles. © 2015 Society of Chemical Industry.

  16. In vivo digestion of bovine milk fat globules: effect of processing and interfacial structural changes. II. Upper digestive tract digestion.

    Science.gov (United States)

    Gallier, Sophie; Zhu, Xiang Q; Rutherfurd, Shane M; Ye, Aiqian; Moughan, Paul J; Singh, Harjinder

    2013-12-01

    The aim of this research was to study the effect of milk processing on the in vivo upper digestive tract digestion of milk fat globules. Fasted rats were serially gavaged over a 5h period with cream from raw, pasteurised, or pasteurised and homogenised milk. Only a few intact dietary proteins and peptides were present in the small intestinal digesta. Significantly (Praw (448 mg g(-1) digesta dry matter (DDM)) and homogenised creams (528 mg g(-1) DDM), as compared to pasteurised and homogenised cream (249 mg g(-1) DDM). Microscopy techniques were used to investigate the structural changes during digestion. Liquid-crystalline lamellar phases surrounding the fat globules, fatty acid soap crystals and lipid-mucin interactions were evident in all small intestinal digesta. Overall, the pasteurised and homogenised cream appeared to be digested to a greater extent. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Etude de l'effet de l'amodiaquine sur les globules rouges infectés ...

    African Journals Online (AJOL)

    Ces images sont ensuite utilisées pour étudier l'interaction du médicament avec les globules rouges en fonction des concentrations, en ayant recours à des techniques d'analyse multivariée telles que la classification hiérarchique, la méthode des k-moyennes et l'analyse en composante principale. Les résultats obtenus ...

  18. Evidence for close side-chain packing in an early protein folding intermediate previously assumed to be a molten globule.

    Science.gov (United States)

    Rosen, Laura E; Connell, Katelyn B; Marqusee, Susan

    2014-10-14

    The molten globule, a conformational ensemble with significant secondary structure but only loosely packed tertiary structure, has been suggested to be a ubiquitous intermediate in protein folding. However, it is difficult to assess the tertiary packing of transiently populated species to evaluate this hypothesis. Escherichia coli RNase H is known to populate an intermediate before the rate-limiting barrier to folding that has long been thought to be a molten globule. We investigated this hypothesis by making mimics of the intermediate that are the ground-state conformation at equilibrium, using two approaches: a truncation to generate a fragment mimic of the intermediate, and selective destabilization of the native state using point mutations. Spectroscopic characterization and the response of the mimics to further mutation are consistent with studies on the transient kinetic intermediate, indicating that they model the early intermediate. Both mimics fold cooperatively and exhibit NMR spectra indicative of a closely packed conformation, in contrast to the hypothesis of molten tertiary packing. This result is important for understanding the nature of the subsequent rate-limiting barrier to folding and has implications for the assumption that many other proteins populate molten globule folding intermediates.

  19. Milk fat globule membrane isolate induces apoptosis in HT-29 human colon cancer cells.

    Science.gov (United States)

    Zanabria, Romina; Tellez, Angela M; Griffiths, Mansel; Corredig, Milena

    2013-02-01

    A native milk fat globule membrane (MFGM) isolate obtained from raw milk was assessed for its anticarcinogenic capacity using a colon cancer cell line (HT-29). To prevent microbial contamination and eliminate the presence of lipopolysaccharide (LPS) in the milk used for MFGM isolation, the milk was obtained from the mammary glands of cows using a catheter. Cell proliferation assays demonstrated a reduction of exponentially growing cancer cells of up to 53%, expressed as DNA synthesis (BrdU test), after 72 h stimulation with 100 μg of MFGM protein per mL. Using a similar MFGM concentration, the sulforhodamine B assay resulted in 57% reduction of cell density after 48 h incubation. This bioactivity was comparable to that of known anticancer drugs, 0.1 mM melphalan and 20 μM C2-ceramide, which achieved a cell division reduction of 25 and 40%, respectively, under the same experimental conditions. The toxic effect of the MFGM extracts on HT-29 cells was confirmed by the significant reduction in lactate dehydrogenase enzyme (LDH) by the residual viable cells. An increase of caspase-3 activity (up to 26%) led to the conclusion that MFGM has an apoptotic effect on HT-29 cancer cells.

  20. Bovine milk fat globule membrane affects virulence expression in Escherichia coli O157:H7.

    Science.gov (United States)

    Tellez, A; Corredig, M; Guri, A; Zanabria, R; Griffiths, M W; Delcenserie, V

    2012-11-01

    The aim of this study was to examine the effect of the bovine milk fat globule membrane (MFGM) on the virulence of Escherichia coli O157:H7. The MFGM was extracted from raw or heat-treated milk, resulting in 2 preparations differing in protein composition. Both heated and raw MFGM exerted an inhibitory effect on Shiga toxin gene expression by E. coli O157:H7 (ratios of -7.69 and -5.96, respectively). Interestingly, the effect was stronger with heated MFGM, with a larger decrease in expression of the virulence gene fliC (ratio of -9.43). The difference in effect observed between heated and raw MFGM could be explained by the difference in protein composition between the 2 preparations. These results show, for the first time, a specific effect of MFGM on expressionof Shiga toxin genes as well as genes involved in the motility of E. coli O157:H7. This may offer a new approach to mitigate the adverse health effects caused by E. coli O157:H7 infections. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  1. Curcumin liposomes prepared with milk fat globule membrane phospholipids and soybean lecithin.

    Science.gov (United States)

    Jin, Hong-Hao; Lu, Qun; Jiang, Jian-Guo

    2016-03-01

    Using thin film ultrasonic dispersion method, the curcumin liposomes were prepared with milk fat globule membrane (MFGM) phospholipids and soybean lecithins, respectively, to compare the characteristics and stability of the 2 curcumin liposomes. The processing parameters of curcumin liposomes were investigated to evaluate their effects on the encapsulation efficiency. Curcumin liposomes were characterized in terms of size distribution, ζ-potential, and in vitro release behavior, and then their storage stability under various conditions was evaluated. The curcumin liposomes prepared with MFGM phospholipids had an encapsulation efficiency of about 74%, an average particle size of 212.3 nm, and a ζ-potential of -48.60 mV. The MFGM liposomes showed higher encapsulation efficiency, smaller particle size, higher absolute value of ζ-potential, and slower in vitro release than soybean liposomes. The retention rate of liposomal curcumin was significantly higher than that of free curcumin. The stability of the 2 liposomes under different pH was almost the same, but MFGM liposomes displayed a slightly higher stability than soybean liposomes under the conditions of Fe(3+), light, temperature, oxygen, and relative humidity. In conclusion, MFGM phospholipids have potential advantages in the manufacture of curcumin liposomes used in food systems. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  2. ARE LARGE, COMETARY-SHAPED PROPLYDS REALLY (FREE-FLOATING) EVAPORATING GAS GLOBULES?

    International Nuclear Information System (INIS)

    Sahai, R.; Güsten, R.; Morris, M. R.

    2012-01-01

    We report the detection of strong and compact molecular line emission (in the CO J = 3-2, 4-3, 6-5, 7-6, 13 CO J = 3-2, HCN, and HCO + J = 4-3 transitions) from a cometary-shaped object (Carina-frEGG1) in the Carina star-forming region (SFR) previously classified as a photoevaporating protoplanetary disk (proplyd). We derive a molecular mass of 0.35 M ☉ for Carina-frEGG1, which shows that it is not a proplyd, but belongs to a class of free-floating evaporating gas globules (frEGGs) recently found in the Cygnus SFR by Sahai et al. Archival adaptive optics near-IR (Ks) images show a central hourglass-shaped nebula. The derived source luminosity (about 8-18 L ☉ ), the hourglass morphology, and the presence of collimated jets seen in Hubble Space Telescope images imply the presence of a jet-driving, young, low-mass star deeply embedded in the dust inside Carina-frEGG1. Our results suggest that the true nature of many or most such cometary-shaped objects seen in massive SFRs and previously labeled as proplyds has been misunderstood, and that these are really frEGGs.

  3. Molecular Dynamics Study on Nucleation Behavior and Lamellar Mergence of Polyethylene Globule Crystallization

    Science.gov (United States)

    Yang, Xiaozhen; Wang, Simiao

    2012-02-01

    The site order parameter (SOP) has been adopted to analyze various order structure formation and distribution during the crystallization of a multi-chain polyethylene globule simulated by molecular dynamics. We found that the nucleation relies on crystallinity fluctuation with increase of amplitude, and the baby nucleus in the fluctuation suddenly appears with different shape and increasing size. In the growth stage, a number of lamellar mergence was observed and their selective behaviors were suggested to be related to the orientation difference between the merging lamellae. We obtained that SOP distribution of all atoms in the system during crystallization appears with two peaks: one for the amorphous phase and the other for the crystalline phase. Mesomorphic structures with medium orders locate between the two peaks as an order promotion pathway. Obtained data show that the medium order structure fluctuates at the growth front and does not always be available; the medium order structure existing at the front is not always good for developing. It is possibly caused by chain entanglement.

  4. Using far-infrared limb brightening to probe isolated dark globules

    International Nuclear Information System (INIS)

    Leung, C.M.; O'brien, E.V.; Dubisch, R.

    1989-01-01

    The problem of radiation transport in dark globules with or without internal heat source, immersed in an isotropic incident interstellar radiation field, is solved. The phenomenon of infrared limb brightening, its dependence on cloud properties, and its observational implications are addressed. Numerical results regarding the dependence of limb brightening on total cloud opacity, luminosity of internal heat source, grain type, dust density distribution, and wavelength of emitted radiation are discussed. Observational implications concerning the use of limb brightening to place an upper limit on the luminosity of an embedded protostar and to determine the grain emissivity law in the far-infrared are examined. For sufficiently large optical depth, the limb-brightening ratio (LBR) is found to be related to the optical depth by a power-law relation in the 140-300 micron wavelength range, where thermal emission from grains peaks. By observing the LBR in this range, this power-law relationship can be exploited to determine the emissivity law of the dust grain in the far-infrared. Both the LBR and the longest wavelength for which limb brightening still occurs are related linearly to the luminosity of the central source. 37 references

  5. Extraction of Pathogenesis-Related Proteins and Phenolics in Sauvignon Blanc as Affected by Grape Harvesting and Processing Conditions

    Directory of Open Access Journals (Sweden)

    Bin Tian

    2017-07-01

    Full Text Available Thaumatin-like proteins (TLPs and chitinases are the two main groups of pathogenesis-related (PR proteins found in wine that cause protein haze formation. Previous studies have found that phenolics are also involved in protein haze formation. In this study, Sauvignon Blanc grapes were harvested and processed in two vintages (2011 and 2012 by three different treatments: (1 hand harvesting with whole bunch press (H-WB; (2 hand harvesting with destem/crush and 3 h skin contact (H-DC-3; and (3 machine harvesting with destem/crush and 3 h skin contact (M-DC-3. The juices were collected at three pressure levels (0.4 MPa, 0.8 MPa and 1.6 MPa, some juices were fermented in 750 mL of wine bottles to determine the bentonite requirement for the resulting wines. Results showed juices of M-DC-3 had significantly lower concentration of proteins, including PR proteins, compared to those of H-DC-3, likely due to the greater juice yield of M-DC-3 and interactions between proteins and phenolics. Juices from the 0.8–1.6 MPa pressure and resultant wines had the highest concentration of phenolics but the lowest concentration of TLPs. This supported the view that TLPs are released at low pressure as they are mainly present in grape pulp but additional extraction of phenolics largely present in skin occurs at higher pressing pressure. Wine protein stability tests showed a positive linear correlation between bentonite requirement and the concentration of chitinases, indicating the possibility of predicting bentonite requirement by quantification of chitinases. This study contributes to an improved understanding of extraction of haze-forming PR proteins and phenolics that can influence bentonite requirement for protein stabilization.

  6. A first comparison of Cosmo-Skymed and TerraSAR-X data over Chamonix Mont-Blanc test-site

    OpenAIRE

    Nicolas , Jean-Marie; Trouvé , Emmanuel; Fallourd , Renaud; Vernier , Flavien; Tupin , Florence; Harant , Olivier; Gay , Michel; Moreau , Luc

    2012-01-01

    International audience; This paper presents the first results obtained with satellite im- age time series (SITS) acquired by Cosmo-SkyMed (CSK) over the Chamonix Mont-Blanc test-site. A CSK SITS made of 39 images is merged with a TerraSAR-X SITS made of 26 images by using the orbital information and co-registration tools developed in the EFIDIR project. The results are illus- trated by the computation of speckle-free images by temporal averaging, by the generation and comparison of topographi...

  7. Effet d'un deficit hydrique sur le trefle blanc (Trifolium repens L.). I. Role d'un apport de potassium

    OpenAIRE

    Shamsun-Noor, L.; Robin, Christophe; Guckert, Armand

    1990-01-01

    Le comportement du trèfle blanc (Trifolium repens L cv Crau) est étudié en situation de contrainte hydrique et après réhydratation en liaison avec la fertilisation potassique. Le déficit en eau occasionne une décroissance progressive importante du potentiel hydrique des feuilles et une fermeture rapide des stomates. Ces manifestations sont accompagnées d’une chute de l’activité photosynthétique et de la fixation symbiotique de l’azote. En présence de potassium, la diminution de l’activité...

  8. Multicriteria analysis of protection actions in the case of transportation of radioactive materials: Regulating the transit of type A packages through the Mont Blanc Tunnel

    International Nuclear Information System (INIS)

    Hubert, P.; Lombard, J.; Pages, P.

    1986-09-01

    The utility function approach (decision analysis) is one of the classical decision aiding techniques that are of interest when performing ALARA analysis. In this paper a case study will serve as an illustration of this technique. The problem which is dealt with is the set up of a regulation applying to the transit of small radioactive material packages (type A) under the Mont Blanc Tunnel which is a major route between France and Italy. This case study is therefore a good example of an ALARA approach applied to a safety problem which implies both a probabilistic risk assessment and the evaluation of very heterogeneous criteria

  9. Comparative proteomics of milk fat globule membrane proteins from transgenic cloned cattle.

    Directory of Open Access Journals (Sweden)

    Shunchao Sui

    Full Text Available The use of transgenic livestock is providing new methods for obtaining pharmaceutically useful proteins. However, the protein expression profiles of the transgenic animals, including expression of milk fat globule membrane (MFGM proteins, have not been well characterized. In this study, we compared the MFGM protein expression profile of the colostrum and mature milk from three lines of transgenic cloned (TC cattle, i.e., expressing recombinant human α-lactalbumin (TC-LA, lactoferrin (TC-LF or lysozyme (TC-LZ in the mammary gland, with those from cloned non-transgenic (C and conventionally bred normal animals (N. We identified 1, 225 proteins in milk MFGM, 166 of which were specifically expressed only in the TC-LA group, 265 only in the TC-LF group, and 184 only in the TC-LZ group. There were 43 proteins expressed only in the transgenic cloned animals, but the concentrations of these proteins were below the detection limit of silver staining. Functional analysis also showed that the 43 proteins had no obvious influence on the bovine mammary gland. Quantitative comparison revealed that MFGM proteins were up- or down-regulated more than twofold in the TC and C groups compared to N group: 126 in colostrum and 77 in mature milk of the TC-LA group; 157 in colostrum and 222 in mature milk of the TC-LF group; 49 in colostrum and 98 in mature milk of the TC-LZ group; 98 in colostrum and 132 in mature milk in the C group. These up- and down-regulated proteins in the transgenic animals were not associated with a particular biological function or pathway, which appears that expression of certain exogenous proteins has no general deleterious effects on the cattle mammary gland.

  10. Molten globule of hemoglobin proceeds into aggregates and advanced glycated end products.

    Directory of Open Access Journals (Sweden)

    Afshin Iram

    Full Text Available Conformational alterations of bovine hemoglobin (Hb upon sequential addition of glyoxal over a range of 0-90% v/v were investigated. At 20% v/v glyoxal, molten globule (MG state of Hb was observed by altered tryptophan fluorescence, high ANS binding, existence of intact heme, native-like secondary structure as depicted by far-UV circular dichroism (CD and ATR-FTIR spectra as well as loss in tertiary structure as confirmed by near-UV CD spectra. In addition, size exclusion chromatography analysis depicted that MG state at 20% v/v glyoxal corresponded to expanded pre-dissociated dimers. Aggregates of Hb were detected at 70% v/v glyoxal. These aggregates of Hb had altered tryptophan environment, low ANS binding, exposed heme, increased β-sheet secondary structure, loss in tertiary structure, enhanced thioflavin T (ThT fluorescence and red shifted Congo Red (CR absorbance. On incubating Hb with 30% v/v glyoxal for 0-20 days, advanced glycation end products (AGEs were detected on day 20. These AGEs were characterised by enhanced tryptophan fluorescence at 450 nm, exposure of heme, increase in intermolecular β-sheets, enhanced ThT fluorescence and red shift in CR absorbance. Comet assay revealed aggregates and AGEs to be genotoxic in nature. Scanning electron microscopy confirmed the amorphous structure of aggregates and branched fibrils of AGEs. The transformation of α-helix to β-sheet usually alters the normal protein to amyloidogenic resulting in a variety of protein conformational disorders such as diabetes, prion and Huntington's.

  11. SUBMILLIMETER ARRAY AND SPITZER OBSERVATIONS OF BOK GLOBULE CB 17: A CANDIDATE FIRST HYDROSTATIC CORE?

    Energy Technology Data Exchange (ETDEWEB)

    Chen Xuepeng; Arce, Hector G.; Dunham, Michael M. [Department of Astronomy, Yale University, Box 208101, New Haven, CT 06520-8101 (United States); Zhang Qizhou; Bourke, Tyler L. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Launhardt, Ralf; Schmalzl, Markus; Henning, Thomas, E-mail: xuepeng.chen@yale.edu [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany)

    2012-06-01

    We present high angular resolution Submillimeter Array (SMA) and Spitzer observations toward the Bok globule CB 17. SMA 1.3 mm dust continuum images reveal within CB 17 two sources with an angular separation of {approx}21'' ({approx}5250 AU at a distance of {approx}250 pc). The northwestern continuum source, referred to as CB 17 IRS, dominates the infrared emission in the Spitzer images, drives a bipolar outflow extending in the northwest-southeast direction, and is classified as a low-luminosity Class 0/I transition object (L{sub bol} {approx} 0.5 L{sub Sun }). The southeastern continuum source, referred to as CB 17 MMS, has faint dust continuum emission in the SMA 1.3 mm observations ({approx}6{sigma} detection; {approx}3.8 mJy), but is not detected in the deep Spitzer infrared images at wavelengths from 3.6 to 70 {mu}m. Its bolometric luminosity and temperature, estimated from its spectral energy distribution, are {<=}0.04 L{sub Sun} and {<=}16 K, respectively. The SMA CO (2-1) observations suggest that CB 17 MMS may drive a low-velocity molecular outflow ({approx}2.5 km s{sup -1}), extending in the east-west direction. Comparisons with prestellar cores and Class 0 protostars suggest that CB 17 MMS is more evolved than prestellar cores but less evolved than Class 0 protostars. The observed characteristics of CB 17 MMS are consistent with the theoretical predictions from radiative/magnetohydrodynamical simulations of a first hydrostatic core, but there is also the possibility that CB 17 MMS is an extremely low luminosity protostar deeply embedded in an edge-on circumstellar disk. Further observations are needed to study the properties of CB 17 MMS and to address more precisely its evolutionary stage.

  12. Body measures and milk production, milk fat globules granulometry and milk fatty acid content in Cabannina cattle breed

    Directory of Open Access Journals (Sweden)

    Ricardo Communod

    2013-03-01

    Full Text Available Aim of the study was to achieve scientific information about body measures and milk production of Cabannina cattle, a local breed reared in northern Italy. Fourteen body measures and five morphologic indexes were recorded from 86 heads enrolled in the herd book. Low differences between males and females of the same age-class were shown. Body measures were generally greater than those reported in previous studies, probably due to recent crosses. With reference to milk production, 991 test-day records from 128 lactations of 59 cows were analysed. Average milk daily production was 8 kg/d in 1st lactation to 10.61 in 3rd (P<0.05; the parameters of the Wood equation draw atypical curves with the exception of curves from spring calving cows. Only 74.5% of lactations with an adjusted R2 >0.75 showed a standard curve, with low persistence (7.7%, high value of d at peak (103 d and peak production of 20.18 kg of milk. Moreover, 100 milk samples (40 to 220 d of lactation were submitted to a granulometric survey by laser scatter technique in order to evaluate the dimensions of fat globules; then milk fat was analyzed by gas chromatography, and desaturase indexes were determined. Cabannina cows showed small fat globules with high specific surface. Furthermore mean diameter of milk fat globules decreased during lactation then rose. Milk fat contained high levels of cis-MUFA, and high desaturase indexes. In conclusion, the low size of Cabannina cattle orients for a limited meat production. Instead milk production has a higher economic potential, aimed at cheese production and human nutrition.

  13. On the molecular origin of the cooperative coil-to-globule transition of poly(N-isopropylacrylamide) in water.

    Science.gov (United States)

    Tavagnacco, L; Zaccarelli, E; Chiessi, E

    2018-04-18

    By means of atomistic molecular dynamics simulations we investigate the behaviour of poly(N-isopropylacrylamide), PNIPAM, in water at temperatures below and above the lower critical solution temperature (LCST), including the undercooled regime. The transition between water soluble and insoluble states at the LCST is described as a cooperative process involving an intramolecular coil-to-globule transition preceding the aggregation of chains and the polymer precipitation. In this work we investigate the molecular origin of such cooperativity and the evolution of the hydration pattern in the undercooled polymer solution. The solution behaviour of an atactic 30-mer at high dilution is studied in the temperature interval from 243 to 323 K with a favourable comparison to available experimental data. In the water soluble states of PNIPAM we detect a correlation between polymer segmental dynamics and diffusion motion of bound water, occurring with the same activation energy. Simulation results show that below the coil-to-globule transition temperature PNIPAM is surrounded by a network of hydrogen bonded water molecules and that the cooperativity arises from the structuring of water clusters in proximity to hydrophobic groups. Differently, the perturbation of the hydrogen bond pattern involving water and amide groups occurs above the transition temperature. Altogether these findings reveal that even above the LCST PNIPAM remains largely hydrated and that the coil-to-globule transition is related with a significant rearrangement of the solvent in the proximity of the surface of the polymer. The comparison between the hydrogen bonding of water in the surrounding of PNIPAM isopropyl groups and in the bulk displays a decreased structuring of solvent at the hydrophobic polymer-water interface across the transition temperature, as expected because of the topological extension along the chain of such interface. No evidence of an upper critical solution temperature behaviour

  14. Indications of the prominent role of elemental sulfur in the formation of the varietal thiol 3-mercaptohexanol in Sauvignon blanc wine.

    Science.gov (United States)

    Araujo, Leandro Dias; Vannevel, Sebastian; Buica, Astrid; Callerot, Suzanne; Fedrizzi, Bruno; Kilmartin, Paul A; du Toit, Wessel J

    2017-08-01

    Elemental sulfur is a fungicide traditionally used to control Powdery Mildew in the production of grapes. The presence of sulfur residues in grape juice has been associated with increased production of hydrogen sulfide during fermentation, which could take part in the formation of the varietal thiol 3-mercaptohexanol. This work examines whether elemental sulfur additions to Sauvignon blanc juice can increase the levels of sought-after varietal thiols. Initial trials were performed in South Africa and indicated a positive impact of sulfur on the levels of thiols. Further experiments were then carried out with New Zealand Sauvignon blanc and confirmed a positive relationship between elemental sulfur additions and wine varietal thiols. The formation of hydrogen sulfide was observed when the addition of elemental sulfur was made to clarified juice, along with an increase in further reductive sulfur compounds. When the addition of sulfur was made to pressed juice, prior to clarification, the production of reductive sulfur compounds was drastically decreased. Some mechanistic considerations are also presented, involving the reduction of sulfur to hydrogen sulfide prior to fermentation. Copyright © 2016. Published by Elsevier Ltd.

  15. The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity

    Directory of Open Access Journals (Sweden)

    Li Endong

    2012-06-01

    Full Text Available Abstract Background Phosphatidylserine receptor is a key molecule that mediates the phagocytosis of apoptotic cells. Milk fat globule-EGF factor 8 (MFG-E8 is a phosphatidylserine receptor that is expressed on various macrophage lineage cells, including microglia in the central nervous system (CNS. Targeted clearance of degenerated neurons by microglia is essential to maintain healthy neural networks. We previously showed that the CX3C chemokine fractalkine is secreted from degenerated neurons and accelerates microglial clearance of neuronal debris via inducing the release of MFG-E8. However, the mechanisms by which microglia produce MFG-E8 and the precise functions of MFG-E8 are unknown. Methods The release of MFG-E8 from microglia treated with conditioned medium from neurons exposed to neurotoxic substances, glutamate or oligomeric amyloid β (oAβ was measured by ELISA. The neuroprotective effects of MFG-E8 and MFG-E8 − induced microglial phagocytosis of oAβ were assessed by immunocytochemistry. The effects of MFG-E8 on the production of the anti-oxidative enzyme hemeoxygenase-1 (HO-1 were determined by ELISA and immunocytochemisty. Results MFG-E8 was induced in microglia treated with conditioned medium from neurons that had been exposed to neurotoxicants, glutamate or oAβ. MFG-E8 significantly attenuated oAβ-induced neuronal cell death in a primary neuron − microglia coculture system. Microglial phagocytosis of oAβ was accelerated by MFG-E8 treatment due to increased CD47 expression in the absence of neurotoxic molecule production, such as tumor necrosis factor-α, nitric oxide, and glutamate. MFG-E8 − treated microglia induced nuclear factor E(2 − related factor 2 (Nrf2 − mediated HO-1 production, which also contributed to neuroprotection. Conclusions These results suggest that microglia release MFG-E8 in response to signals from degenerated neurons and that MFG-E8 protects oAβ-induced neuronal cell death

  16. Instability of a highly vulnerable high alpine rock ridge: the lower Arête des Cosmiques (Mont Blanc massif, France)

    Science.gov (United States)

    Ravanel, L.; Deline, P.; Lambiel, C.; Vincent, C.

    2012-04-01

    Glacier retreat and permafrost degradation are actually more and more thought to explain the increasing instability of rock slopes and rock ridges in high mountain environments. Hot summers with numerous rockfalls we experienced over the last two decades in the Alps have indeed contributed to test/strengthen the hypothesis of a strong correlation between rockfalls and global warming through these two cryospheric factors. Rockfalls from recently deglaciated and/or thawing areas may have very important economic and social implications for high mountain infrastructures and be a fatal hazard for mountaineers. At high mountain sites characterized by infrastructures that can be affected by rockfalls, the monitoring of rock slopes, permafrost and glaciers is thus an essential element for the sustainability of the infrastructure and for the knowledge/management of risks. Our study focuses on a particularly active area of the Mont Blanc massif (France), the lower Arête des Cosmiques, on which is located the very popular Refuge des Cosmiques (3613 m a.s.l.). Since 1998, when a rockfall threatened a part of the refuge and forced to major stabilizing works, observations allowed to identify 10 detachments (20 m3 to > 1000 m3), especially on the SE face of the ridge. Since 2009, this face is yearly surveyed by terrestrial laser scanning to obtain high-resolution 3D models. Their diachronic comparison gives precise measurements of the evolution of the rock slope. Eight rock detachments have thus been documented (0.7 m3 to 256.2 m3). Rock temperature measurements at the ridge and the close Aiguille du Midi (3842 m a.s.l.), and observations of the evolution of the underlying Glacier du Géant have enable to better understand the origin of the strong dynamics of this highly vulnerable area: (i) rock temperature data suggest the presence of warm permafrost (i.e. close to 0°C) from the first meters to depth in the SE face, and cold permafrost in the NW face; (ii) as suggested by the

  17. VizieR Online Data Catalog: Project VeSElkA: HD stars atomic-line analysis (LeBlanc+, 2015)

    Science.gov (United States)

    Leblanc, F.; Khalack, V.; Yameogo, B.; Thibeault, C.; Gallant, I.

    2017-11-01

    The four stars studied here were observed with ESPaDOnS at CFHT. High-resolution (R=65000) Stokes IV spectra with large signal-to-noise ratios were obtained in the spectral range 3700-10500Å and were reduced with the software package LIBRE-ESPRIT (Donati et al. 1997MNRAS.291..658D). Two or more spectra of each star were taken to verify for any spectral variability. For the four stars studied here, no such variability is detected. Also, no strong magnetic fields were found. More details about these observations are given in Khalack & LeBlanc (2015AJ....150....2K); for instance, the exposure times and the signal-to-noise ratios are given in their table 1 for each star studied here. (4 data files).

  18. L’effet de l’ovotransferrine sur les enveloppes bactériennes dans les conditions physicochimiques du blanc d’oeuf

    OpenAIRE

    Rezazadeh Ghazvini, Raheleh

    2017-01-01

    Les protéines de blanc d'oeuf telles que l’ovotransferrine jouent un rôle important dans la défense contre l'invasion bactérienne. L'ovotransferrine a une capacité de liaison du fer, ce qui induit une activité bactériostatique en limitant le fer dans l'environnement des bactéries. Outre le mécanisme bien connu de la privation de fer (Baron et al 2016, pour revue), plusieurs auteurs ont suggéré que l'activité antimicrobienne de l'ovotransferrine pourrait résulter de son effet direct sur les me...

  19. The Mont Blanc neutrinos from SN 1987A: Could they have been monochromatic (8 MeV) tachyons with m2 = - 0.38 keV2?

    Science.gov (United States)

    Ehrlich, Robert

    2018-05-01

    According to conventional wisdom the 5 h early Mont Blanc burst probably was not associated with SN 1987A, but if it was genuine, some exotic physics explanation had to be responsible. Here we consider one truly exotic explanation, namely faster-than-light neutrinos having mν2 = - 0.38 keV2. It is shown that the Mont Blanc burst is consistent with the distinctive signature of that explanation i.e., an 8 MeV antineutrino line from SN 1987A. It is further shown that a model of core collapse supernovae involving dark matter particles of mass 8 MeV would in fact yield an 8 MeV antineutrino line. Moreover, that dark matter model predicts 8 MeV ν ,νbar and e+e- pairs from the galactic center, a place where one would expect large amounts of dark matter to collect. The resulting e+ would create γ - rays from the galactic center, and a fit to MeV γ - ray data yields the model's dark matter mass, as well as the calculated source temperature and angular size. These good fits give indirect experimental support for the existence of an 8 MeV antineutrino line from SN 1987A. More direct support comes from the spectrum of N ∼ 1000 events recorded by the Kamiokande-II detector on the day of SN 1987A, which appear to show an 8 MeV line atop the detector background. This νbar line, if genuine, has been well-hidden for 30 years because it occurs very close to the peak of the background. This fact might ordinarily justify extreme skepticism. In the present case, however, a more positive view is called for based on (a) the very high statistical significance of the result (30σ), (b) the use of a detector background independent of the SN 1987A data using a later K-II data set, and (c) the observation of an excess above the background spectrum whose central energy and width both agree with that of an 8 MeV νbar line broadened by 25% resolution. Most importantly, the last observation is in accord with the prior prediction of an 8 MeV νbar line based on the Mont Blanc data, and

  20. [Interconnection between architecture of protein globule and disposition of conformational conservative oligopeptides in proteins from one protein family].

    Science.gov (United States)

    Batianovskiĭ, A V; Filatov, I V; Namiot, V A; Esipova, N G; Volotovskiĭ, I D

    2012-01-01

    It was shown that selective interactions between helical segments of macromolecules can realize in globular proteins in the segments characterized by the same periodicities of charge distribution i.e. between conformationally conservative oligopeptides. It was found that in the macromolecules of alpha-helical proteins conformationally conservative oligopeptides are disposed at a distance being characteristic of direct interactions. For representatives of many structural families of alpha-type proteins specific disposition of conformationally conservative segments is observed. This disposition is inherent to a particular structural family. Disposition of conformationally conservative segments is not related to homology of the amino acid sequence but reflects peculiarities of native 3D-architectures of protein globules.

  1. Improved organic scintillation detectors; Possibilites de perfectionnement des detecteurs organiques a scintillations; Usovershenstvovannye organicheskie stsintillyatsionnye detektory; Detectores organicos de centelleo perfeccionados

    Energy Technology Data Exchange (ETDEWEB)

    Birks, J B [University of Manchester, Manchester (United Kingdom)

    1962-04-15

    Equations have been derived for the practical scintillation efficiency (photo-electrons/MeV) of organic crystals and solutions in terms of molecular parameters and these have been applied to the more important scintillator systems, for photomultipliers with S11 (glass window) and S13 (quartz window) responses. The results suggest several improvements in current organic scintillation detector practice: the use of binary rather than ternary solutions; the use of quartz rather than glass windows; and the reconsideration of mixed crystal scintillators based on naphthalene. Improvements by factors of 2 or more in the figure of merit (practical efficiency/decay time) for fast-scintillation counting can be obtained. (author) [French] L'auteur a etabli des equations pour determiner le rendement de scintillation (photoelectrons/MeV) de cristaux et solutions organiques, en faisant intervenir des parametres moleculaires. Il a applique ces equations a des appareils a scintillations plus importantes pour determiner la reponse des photomultiplicateurs a fenetre en verre (S11) et a fenetre en quartz (S13). Les resultats obtenus ont fait apparaitre la possibilite d'ameliorer, a plusieurs egards, les detecteurs organiques a scintillations du type courant, par exemple en remplacant les solutions ternaires par des solutions binaires, les fenetres en verre par des fenetres en quartz, ou en reexaminant les possibilites offertes par les scintillateurs a cristaux mixtes a base de naphtalene. L'introduction de ces perfectionnements conduirait a une amelioration, du simple au double ou plus, du facteur de qualite (efficacite/temps de decroissance) des dispositifs de comptage a scintillations. (author) [Spanish] Se han establecido ecuaciones que permiten calcular el rendimiento practico de centelleo (fotoelectrones/MeV) de los cristales y soluciones organicos en funcion de parametros moleculares; estas ecuaciones han sido aplicadas a los sistemas de centelleo mas importantes, para

  2. Limit to the measurement of feeble activities using ionization chambers; Limite des possibilites de mesure de faibles activites au moyen de chambres d'ionisation

    Energy Technology Data Exchange (ETDEWEB)

    Briere, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The present account based on experience acquired in the Biology Service, in measuring feeble activities of tritium and carbon-14 has been prepared for the benefit hose who have to carry out measurements of feeble activities using ionization chambers. Precision are given on the behaviour and actual performance of vibrating condenser electrometers, based on approximately two years operating experience. It is shown that the possibilities of utilisation are not limited as is generally believed by insufficient sensitivity and stability of the electronic equipment, but by the existence of various parasitic phenomena coming from the ionization chamber itself, which make very difficult the measurement of ionization currents which are less than 10{sup -14} A. (author)Fren. [French] Le present compte rendu, base sur l'experience acquise au Service de Biologie dans la mesure de faibles activites de tritium et de carbone-14, est redige a l'intention des personnes ayant a effectuer des mesures de tres faibles activites au moyen de chambres d'ionisation. Il donne des precisions sur le comportement et les performances reelles des electrometres a condensateur vibrant, basees sur environ deux ans d'utilisation, et demontre que les possibilites de mesure ne sont pas limitees - comme on le croit generalement - par l'insuffisance de sensibilite et de stabilite de l'appareillage electronique, mais par l'existence de divers phenomenes parasites dont la chambre d'ionisation est le siege et qui rendent tres difficiles la mesure de courants d'ionisation inferieurs a 10{sup -14} A. (auteur)

  3. Improving the Terrain-Based Parameter for the Assessment of Snow Redistribution in the Col du Lac Blanc Area and Comparisons with TLS Snow Depth Data

    Science.gov (United States)

    Schön, Peter; Prokop, Alexander; Naaim-Bouvet, Florence; Nishimura, Kouichi; Vionnet, Vincent; Guyomarc'h, Gilbert

    2014-05-01

    Wind and the associated snow drift are dominating factors determining the snow distribution and accumulation in alpine areas, resulting in a high spatial variability of snow depth that is difficult to evaluate and quantify. The terrain-based parameter Sx characterizes the degree of shelter or exposure of a grid point provided by the upwind terrain, without the computational complexity of numerical wind field models. The parameter has shown to qualitatively predict snow redistribution with good reproduction of spatial patterns, but has failed to quantitatively describe the snow redistribution, and correlations with measured snow heights were poor. The objective of our research was to a) identify the sources of poor correlations between predicted and measured snow re-distribution and b) improve the parameters ability to qualitatively and quantitatively describe snow redistribution in our research area, the Col du Lac Blanc in the French Alps. The area is at an elevation of 2700 m and particularly suited for our study due to its constant wind direction and the availability of data from a meteorological station. Our work focused on areas with terrain edges of approximately 10 m height, and we worked with 1-2 m resolution digital terrain and snow surface data. We first compared the results of the terrain-based parameter calculations to measured snow-depths, obtained by high-accuracy terrestrial laser scan measurements. The results were similar to previous studies: The parameter was able to reproduce observed patterns in snow distribution, but regression analyses showed poor correlations between terrain-based parameter and measured snow-depths. We demonstrate how the correlations between measured and calculated snow heights improve if the parameter is calculated based on a snow surface model instead of a digital terrain model. We show how changing the parameter's search distance and how raster re-sampling and raster smoothing improve the results. To improve the parameter

  4. Study of the variables which influence the impregnation of globules, compressed tablets and tablet triturates used in homeopathy

    Directory of Open Access Journals (Sweden)

    Fernanda Santos de Souza

    2012-09-01

    Full Text Available Globules, compressed tablets and tablet triturates are solid dosage forms used in homeopathy. Divergences can be noted between the preparation techniques described in official compendiums as well as those applied in homeopathic pharmacies. The difficulty associated with standardization of the impregnation of these dosage forms occurs due to the lack of detail provided for the techniques in the literature, leaving it up to each pharmacy to decide on the exact method of preparation. The objective was to optimize the impregnation technique, through investigating the variables that influence the impregnation of globules, compressed tablets and tablet triturates, applying the statistical tool of factorial design. The independent variables were the dosage form, percentage and type of impregnation and drying temperature, and the dependent variables were the mass gain, disintegration time, friability and hardness. For the globules, the greatest mass gain was for 10% impregnation and drying at 20 ºC. For the tablet triturates and compressed tablets the greatest mass gain was for 15% impregnation and there was no difference between the results obtained using simple and triple impregnation or different drying temperatures. The results can contribute to improving the final product quality, besides aiding in the establishment of standardized techniques for the official compendiums.Glóbulos, comprimidos e tabletes são formas farmacêuticas sólidas utilizadas em homeopatia. Constatam-se divergências entre técnicas de preparação descritas nos compêndios oficiais, bem como em farmácias homeopáticas. A dificuldade de padronização na impregnação destas formas farmacêuticas também ocorre devido à falta de detalhamento das técnicas na literatura existente, deixando para cada farmácia a escolha de como executá-las. O objetivo foi otimizar a técnica de impregnação, através do estudo de variáveis que interferem na impregnação de gl

  5. Merging a Terrain-Based Parameter and Snow Particle Counter Data for the Assessment of Snow Redistribution in the Col du Lac Blanc Area

    Science.gov (United States)

    Schön, Peter; Prokop, Alexander; Naaim-Bouvet, Florence; Vionnet, Vincent; Guyomarc'h, Gilbert; Heiser, Micha; Nishimura, Kouichi

    2015-04-01

    Wind and the associated snow drift are dominating factors determining the snow distribution and accumulation in alpine areas, resulting in a high spatial variability of snow depth that is difficult to evaluate and quantify. The terrain-based parameter Sx characterizes the degree of shelter or exposure of a grid point provided by the upwind terrain, without the computational complexity of numerical wind field models. The parameter has shown to qualitatively predict snow redistribution with good reproduction of spatial patterns. It does not, however, provide a quantitative estimate of changes in snow depths. The objective of our research was to introduce a new parameter to quantify changes in snow depths in our research area, the Col du Lac Blanc in the French Alps. The area is at an elevation of 2700 m and particularly suited for our study due to its consistently bi-modal wind directions. Our work focused on two pronounced, approximately 10 m high terrain breaks, and we worked with 1 m resolution digital snow surface models (DSM). The DSM and measured changes in snow depths were obtained with high-accuracy terrestrial laser scan (TLS) measurements. First we calculated the terrain-based parameter Sx on a digital snow surface model and correlated Sx with measured changes in snow-depths (Δ SH). Results showed that Δ SH can be approximated by Δ SHestimated = α * Sx, where α is a newly introduced parameter. The parameter α has shown to be linked to the amount of snow deposited influenced by blowing snow flux. At the Col du Lac Blanc test side, blowing snow flux is recorded with snow particle counters (SPC). Snow flux is the number of drifting snow particles per time and area. Hence, the SPC provide data about the duration and intensity of drifting snow events, two important factors not accounted for by the terrain parameter Sx. We analyse how the SPC snow flux data can be used to estimate the magnitude of the new variable parameter α . To simulate the development

  6. Zn(II)-PEG 300 globules as soft template for the synthesis of hexagonal ZnO micronuts by the hydrothermal reaction method.

    Science.gov (United States)

    Shi, Xixi; Pan, Lingling; Chen, Shuoping; Xiao, Yong; Liu, Qiaoyun; Yuan, Liangjie; Sun, Jutang; Cai, Lintao

    2009-05-19

    Hexagonal ZnO micronuts (HZMNs) have been successfully synthesized with the assistance of poly(ethylene glycol) (PEG) 300 via a hydrothermal method. The structure and morphology of the HZMNs were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and selected area electron diffraction (SAED). An individual ZnO micronut is revealed as twinned crystals. Time-dependent investigation shows that the growth of HZMNs involves a dissolution-recrystallization process followed by Ostwald ripening, in which is the first formed solid ZnO particles dissolve and transform to HZMNs with hollow structure. PEG 300 has been found to play a crucial role in the growth of this unique hollow structure. TEM observations show that the PEG chains aggregate to globules in water, which then have interaction with the dissolved zinc species to form the globules in a coiled state under hydrothermal conditions. These Zn(II)-PEG 300 globules act as soft template for the growth of HZMNs, and the possible growth mechanism is proposed. The room-temperature photoluminescence (PL) spectrum shows red emission around 612 nm with a full width at half-maximum (fwhm) only about 13 nm.

  7. Evaluation of six sample preparation procedures for qualitative and quantitative proteomics analysis of milk fat globule membrane.

    Science.gov (United States)

    Yang, Yongxin; Anderson, Elizabeth; Zhang, Sheng

    2018-04-12

    Proteomic analysis of membrane proteins is challenged by the proteins solubility and detergent incompatibility with MS analysis. No single perfect protocol can be used to comprehensively characterize the proteome of membrane fraction. Here, we used cow milk fat globule membrane (MFGM) proteome analysis to assess six sample preparation procedures including one in-gel and five in-solution digestion approaches prior to LC-MS/MS analysis. The largest number of MFGM proteins were identified by suspension trapping (S-Trap) and filter-aided sample preparation (FASP) methods, followed by acetone precipitation without clean-up of tryptic peptides method. Protein identifications with highest average coverage was achieved by Chloroform/MeOH, in-gel and S-Trap methods. Most distinct proteins were identified by FASP method, followed by S-Trap. Analyses by Venn diagram, principal-component analysis, hierarchical clustering and the abundance ranking of quantitative proteins highlight differences in the MFGM fraction by the all sample preparation procedures. These results reveal the biased proteins/peptides loss occurred in each protocol. In this study, we found several novel proteins that were not observed previously by in-depth proteomics characterization of MFGM fraction in milk. Thus, a combination of multiple procedures with orthologous properties of sample preparation was demonstrated to improve the protein sequence coverage and expression level accuracy of membrane samples. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Effect of feeding camphor (Eucalyptus Globules) levels on some immunity characteristics, growth and gut microflora of japanese quails

    International Nuclear Information System (INIS)

    Abu Taleb, A.M.; Salah, H.M.; Ezzat, I.E.; El Barkouky, E.

    2003-01-01

    This experiment was conducted to evaluate the effect of adding Eucalyptus globules Egypt to Japanese quail diet on performance and some metabolic functions and immunity. Four hundred,one day old, unsexed japanese quails were used in this study. Quails were divided equally into four groups containing 100 birds in each. Each group contained 4 replicates of 25 birds. Group one was supplemented with 1% Egypt in basal diet, group two was supplemented with 2% Egypt in basal diet, group three was used as negative control (-ve)without any addition of antibiotic in diet or water, while group four represented the positive control (+ ve) by addition antibiotics (0.5 g neomycin sulphate +0.5 g oxytetracyclin) in drinking water for 5 days post hatching. The experimented diet contained 3200 Kcal ME/kg and 24% crude proteins. The end of the experiment was terminated when birds were 6 weeks old. Body weight, mortality, some organs weighs and some blood parameters were measured and some microbial population of small intestines was counted. Results indicated that the addition of Egypt led to significant increase in quails body weights, spleen, bursa and ovary and the measures of total proteins, globulins, haemagglutination inhibition (HI)and triiodothyronine (T3). Decrease in mortality ratio and less counts of microflora and salmonella of gut were also achieved as a result of diet camphor addition

  9. Dust evolution, a global view: III. Core/mantle grains, organic nano-globules, comets and surface chemistry

    Science.gov (United States)

    2016-01-01

    Within the framework of The Heterogeneous dust Evolution Model for Interstellar Solids (THEMIS), this work explores the surface processes and chemistry relating to core/mantle interstellar and cometary grain structures and their influence on the nature of these fascinating particles. It appears that a realistic consideration of the nature and chemical reactivity of interstellar grain surfaces could self-consistently and within a coherent framework explain: the anomalous oxygen depletion, the nature of the CO dark gas, the formation of ‘polar ice’ mantles, the red wing on the 3 μm water ice band, the basis for the O-rich chemistry observed in hot cores, the origin of organic nano-globules and the 3.2 μm ‘carbonyl’ absorption band observed in comet reflectance spectra. It is proposed that the reaction of gas phase species with carbonaceous a-C(:H) grain surfaces in the interstellar medium, in particular the incorporation of atomic oxygen into grain surfaces in epoxide functional groups, is the key to explaining these observations. Thus, the chemistry of cosmic dust is much more intimately related with that of the interstellar gas than has previously been considered. The current models for interstellar gas and dust chemistry will therefore most likely need to be fundamentally modified to include these new grain surface processes. PMID:28083090

  10. Milk Fat Globules Hamper Adhesion of Enterohemorrhagic Escherichia coli to Enterocytes: In Vitro and in Vivo Evidence

    Directory of Open Access Journals (Sweden)

    Thomas Douëllou

    2018-05-01

    Full Text Available Enterohemorrhagic Escherichia coli (EHEC; E. coli are food-borne agents associated with gastroenteritis, enterocolitis, bloody diarrhea and the hemolytic-uremic syndrome (HUS. Bovine milk glycans have been shown to contain oligosaccharides which are similar to host epithelial cell receptors and can therefore prevent bacterial adhesion. This study aimed to describe interactions between EHEC O157:H7 EDL933 and O26:H11 21765 and milk fat globules (MFGs in raw milk and raw milk cheese, and the impact of MFGs on EHEC strains adhesion to the intestinal tract in vitro and in vivo. Both EHEC serotypes clearly associated with native bovine MFGs and significantly limited their adhesion to a co-culture of intestinal cells. The presence of MFGs in raw milk cheese had two effects on the adhesion of both EHEC serotypes to the intestinal tracts of streptomycin-treated mice. First, it delayed and reduced EHEC excretion in mouse feces for both strains. Second, the prime implantation site for both EHEC strains was 6 cm more proximal in the intestinal tracts of mice fed with contaminated cheese containing less than 5% of fat than in those fed with contaminated cheese containing 40% of fat. Feeding mice with 40% fat cheese reduced the intestinal surface contaminated with EHEC and may therefore decrease severity of illness.

  11. Kinetics of Coil-to-Globule Transition of Dansyl-Labeled Poly(N-sopropylacrylamide) Chains in Aqueous Solution

    Science.gov (United States)

    Li, Chun-liang; Ye, Xiao-dong; Ding, Yan-wei; Liu, Shi-lin

    2012-08-01

    The coil-to-globule transition of thermally sensitive linear poly(N-isopropylacrylamide) (PNIPAM) labeled with dansyl group is induced by 1.54 μm laser pulses (width≈10 ns). The dansyl group is used to follow the transition kinetics because its fluorescence intensity is very sensitive to its micro-environment. As the molar ratio of NIPAM monomer to dansyl group increases from 110 to 300, the effect of covalently attached dansyl fluorophores on the transition decreases. In agreement with our previous study in which we used 8-anilino-1-naphthalensulfonic acid ammonium salt free in water as a fluorescent probe, the current study reveals that the transition has two distinct stages with two characteristic times, namely, τfast≈0.1 ms, which can be attributed to the nucleation and formation of some “pearls" (locally contracting segments) on the chain, and τslow≈0.5 ms, which is related to the merging and coarsening of the “pearls". τfast is independent of the PNIPAM chain length over a wide range (Mw=2.8×106-4.2×107 g/mol). On the other hand, τslow only slightly increases with the chain length.

  12. Pulsed electric field processing preserves the antiproliferative activity of the milk fat globule membrane on colon carcinoma cells.

    Science.gov (United States)

    Xu, S; Walkling-Ribeiro, M; Griffiths, M W; Corredig, M

    2015-05-01

    The present work evaluated the effect of processing on the antiproliferative activities of milk fat globule membrane (MFGM) extracts. The antiproliferative activity on human adenocarcinoma HT-29 cells of untreated MFGM extracts were compared with those extracted from pasteurized cream, thermally treated cream, or cream subjected to pulsed electrical field (PEF) processing. The PEF with a 37 kV/cm field strength applied for 1,705μs at 50 and 65°C was applied to untreated cream collected from a local dairy. Heating at 50 or 65°C for 3min (the passage time in the PEF chamber) was also tested to evaluate the heating effect during PEF treatments. The MFGM extracted from pasteurized cream did not show an antiproliferative activity. On the other hand, isolates from PEF-treated cream showed activity similar to that of untreated samples. It was also shown that PEF induced interactions between β-lactoglobulin and MFGM proteins at 65°C, whereas the phospholipid composition remained unaltered. This work demonstrates the potential of PEF not only a means to produce a microbiologically safe product, but also as a process preserving the biofunctionality of the MFGM. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  13. A study of the Herbig-Haro object HH 120 and the associated cometary globule CG 30

    International Nuclear Information System (INIS)

    Pettersson, B.

    1984-01-01

    Infrared and spectroscopic observations are presented of a new Herbig-Haro object, here named HH 120, in the cometary globule CG 30. The emission line spectrum indicates a very low degree of excitation of the same order as that found for HH 47, HH 7, and HH 11. From several spectra a radial velocity of -42 km -1 +-12 km s -1 is deduced and the electron temperature, Tsub(e), and electron number density, Nsub(e), are found to be 9100 K+-400 K and 1700 cm -3 +-600 cm -3 , respectively. A prominent continuum is shown to be composed of a collisionally enhanced two-photon continuum and a reflected late-type stellar component, probably originating in the hidden source of energy. Infrared scans of CG 30 revealed five sources, two of which are very close to HH 120. It is argued that one of them, CG 30-IRS4, is the source of energy producing HH 120 and an associated reflection nebula. The bolometric luminosity of CG 30-IRS4 is estimated to be at least 0.9 Lsub(sun), its mass 1.1 Msub(sun) and its radius 1.6 Rsub(sun). (orig.)

  14. Structural characterization of polysaccharides from Cabernet Franc, Cabernet Sauvignon and Sauvignon Blanc wines: Anti-inflammatory activity in LPS stimulated RAW 264.7 cells.

    Science.gov (United States)

    Bezerra, Iglesias de Lacerda; Caillot, Adriana Rute Cordeiro; Palhares, Lais Cristina Gusmão Ferreira; Santana-Filho, Arquimedes Paixão; Chavante, Suely Ferreira; Sassaki, Guilherme Lanzi

    2018-04-15

    The structural characterization of the polysaccharides and in vitro anti-inflammatory properties of Cabernet Franc (WCF), Cabernet Sauvignon (WCS) and Sauvignon Blanc (WSB) wines were studied for the first time in this work. The polysaccharides of wines gave rise to three fractions of polysaccharides, namely (WCF) 0.16%, (WCS) 0.05% and (WSB) 0.02%; the highest one was chosen for isolation of polysaccharides (WCF). It was identified the presence of mannan, formed by a sequence of α-d-Manp (1 → 6)-linked and side chains O-2 substituted for α-d-mannan (1 → 2)-linked; type II arabinogalactan, formed by (1 → 3)-linked β-d-Galp main chain, substituted at O-6 by (1 → 6)-linked β-d-Galp side chains, and nonreducing end-units of arabinose 3-O-substituted; type I rhamnogalacturonan formed by repeating (1 → 4)-α-d-GalpA-(1 → 2)-α-L-Rhap groups; and traces of type II rhamnogalacturonan. The polysaccharide mixture and isolated fractions inhibited the production of inflammatory cytokines (TNF-α and IL-1β) and mediator (NO) in RAW 264.7 cells stimulated with LPS. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Evaluation of the anti-adhesive effect of milk fat globule membrane glycoproteins on Helicobacter pylori in the human NCI-N87 cell line and C57BL/6 mouse model.

    Science.gov (United States)

    Horemans, Tessa; Kerstens, Monique; Clais, Sofie; Struijs, Karin; van den Abbeele, Pieter; Van Assche, Tim; Maes, Louis; Cos, Paul

    2012-08-01

     The interest in non-antibiotic therapies for Helicobacter pylori infections in man has considerably grown because increasing numbers of antibiotic-resistant strains are being reported. Intervention at the stage of bacterial attachment to the gastric mucosa could be an approach to improve the control/eradication rate of this infection.  Fractions of purified milk fat globule membrane glycoproteins were tested in vitro for their cytotoxic and direct antibacterial effect. The anti-adhesive effect on H. pylori was determined first in a cell model using the mucus-producing gastric epithelial cell line NCI-N87 and next in the C57BL/6 mouse model after dosing at 400 mg/kg protein once or twice daily from day -2 to day 4 post-infection. Bacterial loads were determined by using quantitative real-time PCR and the standard plate count method.  The milk fat globule membrane fractions did not show in vitro cytotoxicity, and a marginal antibacterial effect was demonstrated for defatted milk fat globule membrane at 256 μg/mL. In the anti-adhesion assay, the results varied from 56.0 ± 5.3% inhibition for 0.3% crude milk fat globule membrane to 79.3 ± 3.5% for defatted milk fat globule membrane. Quite surprisingly, in vivo administration of the same milk fat globule membrane fractions did not confirm the anti-adhesive effects and even caused an increase in bacterial load in the stomach.  The promising anti-adhesion in vitro results could not be confirmed in the mouse model, even after the highest attainable exposure. It is concluded that raw or defatted milk fat globule membrane fractions do not have any prophylactic or therapeutic potential against Helicobacter infection. © 2012 Blackwell Publishing Ltd.

  16. Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) Attenuates Cardiac Hypertrophy Through Inhibition of Akt Pathway.

    Science.gov (United States)

    Deng, Ke-Qiong; Li, Jing; She, Zhi-Gang; Gong, Jun; Cheng, Wen-Lin; Gong, Fu-Han; Zhu, Xue-Yong; Zhang, Yan; Wang, Zhihua; Li, Hongliang

    2017-10-01

    Cardiac hypertrophy occurs in response to numerous stimuli like neurohumoral stress, pressure overload, infection, and injury, and leads to heart failure. Mfge8 (milk fat globule-EGF factor 8) is a secreted protein involved in various human diseases, but its regulation and function during cardiac hypertrophy remain unexplored. Here, we found that circulating MFGE8 levels declined significantly in failing hearts from patients with dilated cardiomyopathy. Correlation analyses revealed that circulating MFGE8 levels were negatively correlated with the severity of cardiac dysfunction and remodeling in affected patients. Deleting Mfge8 in mice maintained normal heart function at basal level but substantially exacerbated the hypertrophic enlargement of cardiomyocytes, reprogramming of pathological genes, contractile dysfunction, and myocardial fibrosis after aortic banding surgery. In contrast, cardiac-specific Mfge8 overexpression in transgenic mice significantly blunted aortic banding-induced cardiac hypertrophy. Whereas MAPK (mitogen-activated protein kinase) pathways were unaffected in either Mfge8 -knockout or Mfge8 -overexpressing mice, the activated Akt/PKB (protein kinase B)-Gsk-3β (glycogen synthase kinase-3β)/mTOR (mammalian target of rapamycin) pathway after aortic banding was significantly potentiated by Mfge8 deficiency but suppressed by Mfge8 overexpression. Inhibition of Akt with MK-2206 blocked the prohypertrophic effects of Mfge8 deficiency in angiotensin II-treated neonatal rat cardiomyocytes. Finally, administering a recombinant human MFGE8 in mice in vivo alleviated cardiac hypertrophy induced by aortic banding. Our findings indicate that Mfge8 is an endogenous negative regulator of pathological cardiac hypertrophy and may, thus, have potential both as a novel biomarker and as a therapeutic target for treatment of cardiac hypertrophy. © 2017 American Heart Association, Inc.

  17. The air and noise situation in the alpine transit valleys of Fréjus, Mont-Blanc, Gotthard and Brenner

    Directory of Open Access Journals (Sweden)

    Jürg Thudium

    2009-03-01

    Full Text Available Les conséquences du trafic routier, en termes de nuisances sonores et de qualité de l’air, ont été analysées et comparées pour quatre vallées de transit alpin (Fréjus, Mont Blanc, Gothard et Brenner durant l’année 2004. Au regard du trafic alpin dans son ensemble, des disparités considérables apparaissent entre les vallées étudiées, mais également à l’intérieur de ces mêmes vallées. Les immissions (concentration de polluants produites par unité d’émission du trafic routier sont deux à trois fois plus élevées dans ces vallées alpines qu’en plaine. Ceci s’explique principalement par la topographie et le climat particuliers de ces vallées. À de nombreux points d’observation, les seuils d’immission ont été dépassés. Les vallées sont également affectées durement par la pollution sonore. « L’effet amphithéâtre » transporte le bruit à des altitudes supérieures, qui n’auraient pas été exposées à autant d’irradiation acoustique si la source de nuisances était située à égale distance, mais dans un « paysage ouvert ». De plus, la protection contre le bruit qui se réfléchit sur les pentes est malaisée. En résumé, toutes les vallées de transit étudiées peuvent être considérées comme des régions sensibles.The environmental consequences of road transport with regard to air and noise in the transit valleys of Fréjus, Mont-Blanc, Gotthard, and Brenner have been analysed and compared with each other for the year 2004. In respect of the share of transport passing through the Alps in transport as a whole, there are in part considerable differences between the valleys under investigation as well as within the individual valleys. The air pollution produced per emission unit of road transport is two to three times higher than in the open country, mainly because of the topography and the climate. At numerous monitoring points, the thresholds for the air pollution were exceeded

  18. Surface and thickness variations of Brenva Glacier tongue (Mont Blanc, Italian Alps) in the second half of the 20th century by historical maps and aerial photogrammetry comparisons

    Science.gov (United States)

    D Agata, C.; Zanutta, A.; Muzzu Martis, D.; Mancini, F.; Smiraglia, C.

    2003-04-01

    Aim of this contribution is the evaluation of volumetric and surface variations of Brenva Glacier (Mont Blanc, Italian Alps) during the second half of the 20th century, by GIS-based processing of maps and aerial photogrammetry technique. Brenva Glacier is a typical debris covered glacier, located in a valley on the S-E side of the Mont Blanc. The glacier covers a surface of 7 kmq and shows a length of 7,6 km at maximum. The glacier snout reaches 1415 m a.s.l., which is the lowest glacier terminus of the Italian Alps. To evaluate glacier variations different historical maps were used: 1) The 1959 Map, at the scale 1:5.000, by EIRA (Ente Italiano Rilievi Aerofotogrammetrici, Firenze), from terrestrial photogrammetric survey, published in the Bollettino del Comitato Glaciologico Italiano, 2, n. 19, 1971. 2) The 1971 Map, at the scale 1:5.000, from aerial photogrammetry (Alifoto, Torino) published in the Bollettino del Comitato Glaciologico Italiano, 2, n. 20, 1972. 3) The 1988 Map, at the scale 1:10.000, (Region Aosta Valley, Regional Technical Map) from 1983 aerial photogrammetric survey. 4) The 1999 Map, at the scale 1:10.000, (Region Aosta Valley, Regional Technical Map) from 1991 aerial photogrammetry survey. For the same purpose the following aereal photographs were used: 1) The 1975 image, CGR (Italian General Company aerial Surveys) flight RAVDA (Administrative Autonomous Region Aosta Valley), at the scale 1:17.000. 2) The 1991 image, CGR (Italian General Company aerial Surveys) flight RAVDA (Administrative Autonomous Region Aosta Valley), at the scale 1:17.000. Aerial imageries have been acquired over a long period from 1975 to 1991. The black and white images were scanned at suitable resolution if compared with the imagery scale and several models, representing the glacier tongue area, oriented using the inner and outer orientation parameters delivered with the images, were produced. The digital photogrammetric system, after orientation and matching, produces

  19. Thermodynamic analysis of ANS binding to partially unfolded α-lactalbumin: correlation of endothermic to exothermic changeover with formation of authentic molten globules.

    Science.gov (United States)

    Kim, Ki Hyung; Yun, Soi; Mok, K H; Lee, E K

    2016-09-01

    A fluorescent reporter, 8-anilino-1-naphthalene sulfonic acid (ANS), can serve as a reference molecule for conformational transition of a protein because its aromatic carbons have strong affinity with hydrophobic cores of partially unfolded molten globules. Using a typical calcium-binding protein, bovine α-lactalbumin (BLA), as a model protein, we compared the ANS binding thermodynamics to the decalcified (10 mM EDTA treated) apo-BLA at two representative temperatures: 20 and 40 °C. This is because the authentic molten globule is known to form more heavily at an elevated temperature such as 40 °C. Isothermal titration calorimetry experiments revealed that the BLA-ANS interactions at both temperatures were entropy-driven, and the dissociation constants were similar on the order of 10(-4)  M, but there was a dramatic changeover in the binding thermodynamics from endothermic at 20 °C to exothermic at 40 °C. We believe that the higher subpopulation of authentic molten globules at 40 °C than 20 °C would be responsible for the results, which also indicate that weak binding is sufficient to alter the ANS binding mechanisms. We expect that the thermodynamic properties obtained from this study would serve as a useful reference for investigating the binding of other hydrophobic ligands such as oleic acid to apo-BLA, because oleic acid is known to have tumor-selective cytotoxicity when complexed with partially unfolded α-lactalbumin. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  20. Effect of Lenient Steam Injection (LSI) heat treatment of bovine milk on the activities of some enzymes, the milk fat globule and pH

    DEFF Research Database (Denmark)

    Dickow, Jonatan A.; Nielsen, Martin Thorup; Hammershøj, Marianne

    2012-01-01

    This study investigated the effects of Lenient Steam Injection (LSI) treatment at temperatures 70–150 C on the enzymatic activities of the indigenous milk enzymes alkaline phosphatase, lactoperoxidase (LPO), xanthine oxidase (XO), lipoprotein lipase (LPL) and plasmin in comparison with two...... reference heat treatments of 63 C for 30 s and of 72 C for 15 s by indirect heating. Milk fat globule (MFG) size distributions and pH were also monitored. Alkaline phosphatase, LPO, XO and LPL activities decreased with increasing LSI temperature. Plasmin activity was increased at temperatures

  1. Heterogeneity of equilibrium molten globule state of cytochrome c induced by weak salt denaturants under physiological condition.

    Directory of Open Access Journals (Sweden)

    Hamidur Rahaman

    Full Text Available While many proteins are recognized to undergo folding via intermediate(s, the heterogeneity of equilibrium folding intermediate(s along the folding pathway is less understood. In our present study, FTIR spectroscopy, far- and near-UV circular dichroism (CD, ANS and tryptophan fluorescence, near IR absorbance spectroscopy and dynamic light scattering (DLS were used to study the structural and thermodynamic characteristics of the native (N, denatured (D and intermediate state (X of goat cytochorme c (cyt-c induced by weak salt denaturants (LiBr, LiCl and LiClO4 at pH 6.0 and 25°C. The LiBr-induced denaturation of cyt-c measured by Soret absorption (Δε400 and CD ([θ]409, is a three-step process, N ↔ X ↔ D. It is observed that the X state obtained along the denaturation pathway of cyt-c possesses common structural and thermodynamic characteristics of the molten globule (MG state. The MG state of cyt-c induced by LiBr is compared for its structural and thermodynamic parameters with those found in other solvent conditions such as LiCl, LiClO4 and acidic pH. Our observations suggest: (1 that the LiBr-induced MG state of cyt-c retains the native Met80-Fe(III axial bond and Trp59-propionate interactions; (2 that LiBr-induced MG state of cyt-c is more compact retaining the hydrophobic interactions in comparison to the MG states induced by LiCl, LiClO4 and 0.5 M NaCl at pH 2.0; and (3 that there exists heterogeneity of equilibrium intermediates along the unfolding pathway of cyt-c as highly ordered (X1, classical (X2 and disordered (X3, i.e., D ↔ X3 ↔ X2 ↔ X1 ↔ N.

  2. Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury.

    Science.gov (United States)

    Cen, Cindy; Aziz, Monowar; Yang, Weng-Lang; Zhou, Mian; Nicastro, Jeffrey M; Coppa, Gene F; Wang, Ping

    2017-06-01

    Acute kidney injury (AKI) is most commonly caused by sepsis in critically ill patients, and it is associated with high morbidity and mortality. The pathophysiology of sepsis-induced AKI is generally accepted to include direct inflammatory injury, endothelial cell dysfunction, and apoptosis. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein with a known role in the enhancement of apoptotic cell clearance and regulation of inflammation. We hypothesize that administration of recombinant mouse MFG-E8 (rmMFG-E8) can protect mice from kidney injuries caused by sepsis. Sepsis was induced in 8-wk-old male C57BL/6 mice by cecal ligation and puncture (CLP). rmMFG-E8 or phosphate-buffered saline (vehicle) was injected intravenously at a dosage of 20 μg/kg body weight at time of CLP (n = 5-8 mice per group). After 20 h, serum and renal tissue were harvested for various analyses. The renal injury markers blood urea nitrogen (BUN) and creatinine were determined by enzymatic and chemical reactions, respectively. The gene expression analysis was carried out by real-time quantitative polymerase chain reaction. At 20 h after CLP, serum levels of BUN and creatinine were both significantly increased in the vehicle group compared with the sham group, whereas the mice treated with rmMFG-E8 had a significant reduction in BUN and creatinine levels by 28% and 24.1%, respectively (BUN: 197.7 ± 23.6 versus 142.3 ± 20.7 mg/dL; creatinine: 0.83 ± 0.12 versus 0.63 ± 0.06 mg/dL; P sepsis through inhibiting the production of proinflammatory cytokines and chemokine, as well as through the activation of endothelial cells. Thus, MFG-E8 may have a therapeutic potential for treating AKI induced by sepsis. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases

    Directory of Open Access Journals (Sweden)

    Young-Su Yi

    2016-01-01

    Full Text Available Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. Milk fat globule-epidermal growth factor 8 (MFG-E8 is a secreted protein found in vertebrates and was initially discovered as a critical component of the milk fat globule. Previously, a number of studies have reported that MFG-E8 contributes to various biological functions including the phagocytic removal of damaged and apoptotic cells from tissues, the induction of VEGF-mediated neovascularization, the maintenance of intestinal epithelial homeostasis, and the promotion of mucosal healing. Recently, emerging studies have reported that MFG-E8 plays a role in inflammatory responses and inflammatory/autoimmune diseases. This review describes the characteristics of MFG-E8-mediated signaling pathways, summarizes recent findings supporting the roles of MFG-E8 in inflammatory responses and inflammatory/autoimmune diseases, and discusses MFG-E8 targeting as a potential therapeutic strategy for the development of anti-inflammatory/autoimmune disease drugs.

  4. Milk Fat Globule Membrane Attenuates High-Fat Diet-Induced Obesity by Inhibiting Adipogenesis and Increasing Uncoupling Protein 1 Expression in White Adipose Tissue of Mice

    Directory of Open Access Journals (Sweden)

    Tiange Li

    2018-03-01

    Full Text Available Milk fat globule membrane (MFGM, a protein-lipid complex surrounding the fat globules in milk, has many health benefits. The aim of the current study was to investigate whether MFGM could prevent obesity through inhibiting adipogenesis and promoting brown remodeling of white adipose tissue (WAT in mice fed with high-fat diet. C57BL/6 mice were fed a normal diet (ND, high-fat diet (HFD, HFD plus MFGM at 100 mg/kg BW, 200 mg/kg BW or 400 mg/kg BW for 8 weeks. Results showed that MFGM suppressed body weight gain induced by HFD, reduced white adipose tissue (WAT mass accompanied with the decrease in adipocyte sizes. MFGM was found to have partially improved serum lipid profiles, as well as to have suppressed HFD-induced adipogenesis as shown by reduced expression of peroxisome proliferators-activator receptor-γ (PPARγ, CCAAT/enhancer-binding protein-α (C/EBPα and sterol regulatory element-binding protein-1c (SREBP-1c. MFGM also markedly increased the phosphorylation of AMP-activated protein kinase (AMPK and acetyl-CoA carboxylase (ACC, showing activation of AMPK pathway. Moreover, MFGM promoted browning of inguinal WAT by upregulation the protein expression of uncoupling protein 1 (UCP1 in HFD mice. Taken together, these findings provide evidence that MFGM may protect against diet-induced adiposity by suppressing adipogenesis and promoting brown-like transformation in WAT.

  5. Charakterisierung der Birnenaromatik von Österreichischem Weißburgunder (Pinot blanc hinsichtlich Typizität und Qualität

    Directory of Open Access Journals (Sweden)

    Philipp Christian

    2017-01-01

    Full Text Available Österreich ist mit einer Anbaufläche von 1.914 ha das drittgrößte Weißburgunder-produzierende Land der Welt. Diese Fläche entspricht 4,3% der österreichischen Weinbaufläche und 12,3% der Weltanbaufläche von Weißburgunder (15.493 ha. Nur in Deutschland (4.794 ha, 30,9% und in Italien (3.086 ha; 19,9% wird mehr Pinot blanc angebaut. Das Aroma von trockenem Weißburgunder ist in der Regel diskret, mit vorherrschenden Birnen- und Apfelaromen, diese kommen oft mit einem Nussaroma und einem Hauch von Blüten (Akazienblüten und Kräutern zusammen. Der Geschmack ist zart und vollmundig. Gereifte Weine zeigen oft Honig- und Mandelnoten. Ethyl-trans2-cis4-decadienoat ist bekannt als Leitaroma in frischen und verarbeiteten Birnenprodukten. Diese Verbindung wurde bis jetzt nicht in Wein beschrieben. Im Rahmen dieser Studie wurde der Gehalt an Ethyl-trans2-cis4-Decadienoat und anderen Ethyl- und Methylester der cis-trans-Isomere der Decadiensäure sowie andere mit Birne assoziierten Aromen (Isoamylacetat, Methyl-trans-Geranoat, Ethylhexanoat, Ethyloctanoat, Ethyldecanoat und Ethyldodecanoat in österreichischen Weißburgunderproben direkt in Wein mit HS-SPME-SIM-MS analysiert. Bei den Analysen konnten relevante Quantitäten an Ethyl-trans-2-cis-4-decadienoat gefunden werden. Die Konzentrationen der untersuchten Weine lagen zwischen >0,036 und 4,04 μg/L. Ein vorangegangener Test zur Feststellung des Wahrnehmungsschwellenwertes nach dem BET-3-Alternative-Forced-Choice-Verfahren ergab bei dieser Verbindung einen Wert von 2 μg/L. Somit ist der Aromastoff teilweise relevant für den Charakter der untersuchten Weine. Die Aromen wurden nach einer Konsumentenstudie ausgesucht und die sogenannte “birnenspezifische Odour Activity Value” nach zwei Verfahren berechnet. Im Zuge der sensorischen und analytischen Studien konnte festgestellt werden, dass ein Zusammenspiel einiger analysierten Aromen für den Charakter, die Qualität und die Typizit

  6. Snow control on active layer and permafrost in steep alpine rock walls (Aiguille du Midi, 3842 m a.s.l, Mont Blanc massif)

    Science.gov (United States)

    Magnin, Florence; Westermann, Sebastian; Pogliotti, Paolo; Ravanel, Ludovic; Deline, Philip

    2016-04-01

    Permafrost degradation through the thickening of the active layer and the rising temperature at depth is a crucial process of rock wall stability. The ongoing increase in rock falls observed during hot periods in mid-latitude mountain ranges is regarded as a result of permafrost degradation. However, the short-term thermal dynamics of alpine rock walls are misunderstood since they result of complex processes related to the interaction of local climate variables, heterogeneous snow cover and heat transfers. As a consequence steady-state and long-term changes that can be approached with simpler process mainly related to air temperature, solar radiations and heat conduction were the most common dynamics to be studied so far. The effect of snow on the bedrock surface temperature is increasingly investigated and has already been demonstrated to be an essential factor of permafrost distribution. Nevertheless, its effect on the year-to-year changes of the active layer thickness and of the permafrost temperature in steep alpine bedrock has not been investigated yet, partly due to the lack of appropriate data. We explore the role of snow accumulations on the active layer and permafrost thermal regime of steep rock walls of a high-elevated site, the Aiguille du Midi (AdM, 3842 m a.s.l, Mont Blanc massif, Western European Alps) by mean of a multi-methods approach. We first analyse six years of temperature records in three 10-m-deep boreholes. Then we describe the snow accumulation patterns on two rock faces by means of automatically processed camera records. Finally, sensitivity analyses of the active layer thickness and permafrost temperature towards timing and magnitude of snow accumulations are performed using the numerical permafrost model CryoGrid 3. The energy balance module is forced with local meteorological measurements on the AdM S face and validated with surface temperature measurements at the weather station location. The heat conduction scheme is calibrated with

  7. Modelling rock wall permafrost degradation in the Mont Blanc massif from the LIA to the end of the 21st century

    Science.gov (United States)

    Magnin, Florence; Josnin, Jean-Yves; Ravanel, Ludovic; Pergaud, Julien; Pohl, Benjamin; Deline, Philip

    2017-08-01

    High alpine rock wall permafrost is extremely sensitive to climate change. Its degradation has a strong impact on landscape evolution and can trigger rockfalls constituting an increasing threat to socio-economical activities of highly frequented areas; quantitative understanding of permafrost evolution is crucial for such communities. This study investigates the long-term evolution of permafrost in three vertical cross sections of rock wall sites between 3160 and 4300 m above sea level in the Mont Blanc massif, from the Little Ice Age (LIA) steady-state conditions to 2100. Simulations are forced with air temperature time series, including two contrasted air temperature scenarios for the 21st century representing possible lower and upper boundaries of future climate change according to the most recent models and climate change scenarios. The 2-D finite element model accounts for heat conduction and latent heat transfers, and the outputs for the current period (2010-2015) are evaluated against borehole temperature measurements and an electrical resistivity transect: permafrost conditions are remarkably well represented. Over the past two decades, permafrost has disappeared on faces with a southerly aspect up to 3300 m a.s.l. and possibly higher. Warm permafrost (i.e. > - 2 °C) has extended up to 3300 and 3850 m a.s.l. in N and S-exposed faces respectively. During the 21st century, warm permafrost is likely to extend at least up to 4300 m a.s.l. on S-exposed rock walls and up to 3850 m a.s.l. depth on the N-exposed faces. In the most pessimistic case, permafrost will disappear on the S-exposed rock walls at a depth of up to 4300 m a.s.l., whereas warm permafrost will extend at a depth of the N faces up to 3850 m a.s.l., but possibly disappearing at such elevation under the influence of a close S face. The results are site specific and extrapolation to other sites is limited by the imbrication of local topographical and transient effects.

  8. Non-equilibrium effects evidenced by vibrational spectra during the coil-to-globule transition in poly(N-isopropylacrylamide) subjected to an ultrafast heating-cooling cycle.

    Science.gov (United States)

    Deshmukh, Sanket A; Kamath, Ganesh; Suthar, Kamlesh J; Mancini, Derrick C; Sankaranarayanan, Subramanian K R S

    2014-03-14

    Molecular dynamics simulations in conjunction with finite element calculations are used to explore the conformational dynamics of a thermo-sensitive oligomer, namely poly(N-isopropylacrylamide) (PNIPAM), subjected to an ultra-fast heating-cooling cycle. Finite element (FE) calculations were used to predict the temperature profile resulting from laser-induced heating of the polymer-aqueous system. The heating rate (∼0.6 K ps(-1)) deduced from FE calculations was used to heat an aqueous solution of PNIPAM consisting of 30 monomeric units (30-mer) from 285 K to 315 K. Non-equilibrium effects arising from the ultra-fast heating-cooling cycle results in a hysteresis during the coil-to-globule transition. The corresponding atomic scale conformations were characterized by monitoring the changes in the vibrational spectra, which provided a reliable metric to study the coil-to-globule transition in PNIPAM and vice-versa across the LCST. The vibrational spectra of bonds involving atoms from the oligomer backbone and the various side-groups (amide I, amide II, and the isopropyl group of PNIPAM) of the oligomers were analyzed to study the conformational changes in the oligomer corresponding to the observed hysteresis. The differences in the vibrational spectra calculated at various temperatures during heating and cooling cycles were used to understand the coil-to-globule and globule-to-coil transitions in the PNIPAM oligomer and identify the changes in the relative interactions between various atoms in the backbone and in the side groups of the oligomer with water. The shifts in the computed vibrational spectral peaks and the changes in the intensity of peaks for the different regions of PNIPAM, seen across the LCST during the heating cycle, are in good agreement with previous experimental studies. The changes in the radius of gyration (Rg) and vibrational spectra for amide I and amide II regions of PNIPAM suggest a clear coil-to-globule transition at ∼301 K during the

  9. Monsieur Etienne Blanc Premier vice-président de la Région Auvergne-Rhône-Alpes Délégué aux finances, à l'administration générale, aux économies budgétaires et aux politiques transfrontalières

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2017-01-01

    Monsieur Etienne Blanc Premier vice-président de la Région Auvergne-Rhône-Alpes Délégué aux finances, à l'administration générale, aux économies budgétaires et aux politiques transfrontalières

  10. Climbing Mont Blanc and Scalability

    OpenAIRE

    Chavez, Christian

    2016-01-01

    This thesis details a proposed system implementation upgrade for the CMB system, accessible at \\url{climb.idi.ntnu.no}, which profiles C/C++ code for its energy efficiency on an Odroid-XU3 board, which utilises a Samsung Exynos 5 Octa CPU, and has an ARM Mali-T628 GPU. Our proposed system implementation improves the robustness of the code base and its execution, in addition to permitting an increased throughput of submissions profiled by the system with the implementation's dispatcher whic...

  11. Quand Hollywood lave plus blanc...

    Directory of Open Access Journals (Sweden)

    André Bleikasten

    2006-03-01

    Full Text Available Alexandre Dumas pensait (je cite de mémoire que « l’on peut violer l’Histoire à condition de lui faire un bel enfant ». Il savait de quoi il parlait, il lui en avait fait d’assez beaux. La métaphore, c’est entendu, n’est pas du meilleur goût, mais, s’agissant de la question toujours controversée de l’adaptation cinématographique, l’idée me paraît assez juste. Un cinéaste peut s’emparer d’un roman pour le malmener, le triturer et le défigurer, le tirer vers lui au point de le rendre méconnais...

  12. Couleur versus noir et blanc

    OpenAIRE

    Boulouch, Nathalie

    2008-01-01

    La couleur n’est entrée que tardivement dans la pratique photographique, avec la production industrielle de la plaque Autochrome Lumière en 1907. Après cette première étape, la commercialisation des procédés à développement chromogène à partir du milieu des années 1930 marquera un nouveau palier, ouvrant l’ère de la photographie couleur moderne. Au-delà du progrès technique généralement retenu, on s’attachera ici au fait que les procédés couleur introduisent une nouvelle catégorie dans le cha...

  13. Possibilités de contribution de la gazéification Lurgi à notre approvisionnement énergétique futur Potential Contribution of Lurgi Gasification to Our Future Energy Supplies

    Directory of Open Access Journals (Sweden)

    Eckert G.

    2006-11-01

    Full Text Available Pour la valorisation du charbon, la gazéification est une possibilité immédiatement utilisable et industriellement éprouvée, qui présente l'avantage de permettre la production des formes d'énergie secondaire, auxquelles nous sommes habitués. Indépendamment du produit final, une unité de conversion du charbon est toujours constituée d'étapes de transformation successives, mettant en oeuvre des procédés adaptés, parmi lesquels la gazéification de charbon proprement dite constitue la première étape qui n'est cependant qu'une opération parmi d'autres. Le traitement des gaz et la séparation des produits secondaires sont mis en oeuvre également et sont importants dans l'ensemble du complexe de traitement. Dans la communication présentée, trois possibilités différentes sont évoquées : - production de gaz de chauffage de différents pouvoirs calorifiques ; - production de méthanol et transformation éventuelle de celui-ci en essence ; - production d'hydrocarbures par la synthèse de Fischer-Tropsch. Une approche économique générale dégage une idée d'ensemble sur la situation et l'intérêt des techniques de conversion du charbon à l'heure actuelle. For the upgrading of coal, gasification is an immediately available and industrially well-proven possibility which has the advantage of making it possible to produce the types of secondary energy to which we have become accustomed. Independently of the end product, a coal conversion plant always consists of successive transformation steps making use of suitable processes, among which coal gasification itself is the first such step, although being only one operation among others. Gas processing and secondary products separation are also implemented and are important in the overall processing complex. This article brings out three different possibilities: (a production of fuel gas with different heating values; (b production of methanol and eventual transformation into gasoline

  14. Hamman Philippe, Blanc Christine, 2009, Sociologie du développement urbain durable. Projets et stratégies métropolitaines françaises, Bruxelles, P.I.E Peter Lang, 260p.

    Directory of Open Access Journals (Sweden)

    Bruno Villalba

    2009-10-01

    Full Text Available Cet ouvrage, réalisé en collaboration avec Flore Henninger, préfacé par Viviane Claude et postfacé par Corinne Larrue, est dirigé par Philippe Hamman (maître de conférences en sociologie au département d’urbanisme de l’UFR de sciences sociales, pratiques sociales et développement de l’université de Strasbourg ; il a dirigé, en 2008, Penser le développement durable urbain : regards croisés, Paris, L’Harmattan et Christine Blanc (sociologue et urbaniste, chargée d’études au Centre de recherche...

  15. Compte rendu de : La vallée électrique,Foëx E. (photographies) et Broennimann T. (textes), 2006, Paris, InFolio éditions, 164 p., 210 photographies en noir et blanc

    OpenAIRE

    Buisson, André

    2008-01-01

    Réunies sous le titre La vallée électrique, 210 photographies en noir et blanc du photographe Emmanuel Foëx illustrent l’architecture industrielle, l’urbanisme et le paysage dans l’Arc alpin. Comme un ouvrage classique, l’album est divisé en trois parties : La centrale, le réseau, le transformateur. L’auteur est parti de l’évidence qu’à travers l’arc alpin, les sillons des vallées sont constellés d’usines consacrées à la fabrication de l’électricité (La centrale). La montagne, telle un châtea...

  16. Milk Fat Globule-Epidermal Growth Factor-8 Pretreatment Attenuates Apoptosis and Inflammation via the Integrin-β3 Pathway after Surgical Brain Injury in Rats

    Directory of Open Access Journals (Sweden)

    Yicai Xiao

    2018-02-01

    Full Text Available Iatrogenic brain injury inevitably occurs in neurosurgical operations, leading to brain edema, ischemia, intracranial hematoma, and other postoperative complications, eventually worsening neurological outcomes of patients. If apoptotic cells are not rapidly eliminated by phagocytic engulfment, they may communicate with surrounding cells to undergo secondary necrosis and releasing toxic signals. Recent studies have shown that milk fat globule-epidermal growth factor-8 (MFGE8, which promotes phagocytosis and inhibits inflammation, is an endogenous protective factor in response to brain infarction, Alzheimer’s disease, subarachnoid hemorrhage, and prion disease. In the present study, we sought to investigate the different effects of both pretreated and posttreated recombinant milk fat globule-epidermal growth factor-8 (rhMFGE8 for the surgical brain injury (SBI rat model and potential involvement of its receptor integrin β3 for apoptosis and neuroinflammation after SBI. One hundred and sixty-seven male rats were employed in the preset study. Experiment 1 was performed to evaluate neurological scores and MFGE8, cleaved caspase-3 (CC3, and interleukine-1 beta (IL-1β levels at 3, 24, and 120 h after SBI. Experiment 2 was performed to evaluate the effects of rhMFGE8 pretreatment (10 min before SBI and rhMFGE8 posttreatment (6 h after SBI on brain edema at 24 and 72 h after SBI. Experiment 3 was performed to evaluate the potential anti-apoptotic and anti-inflammatory effects of rhMFGE8 pretreatment and posttreatment. Experiment 4 sought to investigate the involvement of the integrin-β3 signal in the effects of MFGE8 pretreatment. Our data showed rhMFGE8 pretreatment alleviated neurological deficits and decreased brain water content and apoptotic cells in the SBI model, which exhibited neurological dysfunction, apoptosis, and inflammation. Meanwhile, MFGE8 siRNA, which inhibited endogenous MFGE8 expression, significantly increased IL-1

  17. Elevated serum milk fat globule-epidermal growth factor 8 levels in type 2 diabetic patients are suppressed by overweight or obese status.

    Science.gov (United States)

    Li, Yuanyuan; Ran, Wenzhuo; Zhang, Jiaqiang; Chen, Shi; Li, Yihang; Luo, Deng; Wang, Chen; Jia, Weiping

    2017-02-01

    Inflammation is the most important link between obesity and type 2 diabetes (T2D). Although milk fat globule-epidermal growth factor 8 (MFG-E8) is a key mediator in anti-inflammatory responses, its role in obesity and diabetes is not yet completely understood. We aimed to measure MFG-E8 serum levels and to explore the role of MFG-E8 in obesity and T2D. Fasting serum MFG-E8 levels were quantified by enzyme-linked immunosorbent assay for 168 individuals, whose oral glucose tolerance test was conducted, and levels of inflammatory factors, including tumor necrosis factor-α (TNF-α) and C-reactive protein, were measured. The participants were subdivided into 66 newly diagnosed T2D individuals, 44 impaired glucose tolerance (IGT) subjects and 58 healthy controls. Their characteristics were further classified as lean or nonlean for investigation. MFG-E8 levels were significantly higher in T2D subjects than in healthy controls (P = 0.028). Decreased levels of MFG-E8 were found in overweight or obese individuals, compared to those in lean subjects, in both the T2D and IGT groups (P obesity and T2D in the clinical setting. © 2017 IUBMB Life, 69(2):63-71, 2017. © 2017 International Union of Biochemistry and Molecular Biology.

  18. Molten Globule-Like Partially Folded State of Bacillus licheniformis α-Amylase at Low pH Induced by 1,1,1,3,3,3-Hexafluoroisopropanol

    Directory of Open Access Journals (Sweden)

    Adyani Azizah Abd Halim

    2014-01-01

    Full Text Available Effect of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP on acid-denatured Bacillus licheniformis α-amylase (BLA at pH 2.0 was investigated by far-UV CD, intrinsic fluorescence, and ANS fluorescence measurements. Addition of increasing HFIP concentrations led to an increase in the mean residue ellipticity at 222 nm (MRE222 nm up to 1.5 M HFIP concentration beyond which it sloped off. A small increase in the intrinsic fluorescence and a marked increase in the ANS fluorescence were also observed up to 0.4 M HFIP concentration, both of which decreased thereafter. Far- and near-UV CD spectra of the HFIP-induced state observed at 0.4 M HFIP showed significant retention of the secondary structures closer to native BLA but a disordered tertiary structure. Increase in the ANS fluorescence intensity was also observed with the HFIP-induced state, suggesting exposure of the hydrophobic clusters to the solvent. Furthermore, thermal denaturation of HFIP-induced state showed a non-cooperative transition. Taken together, all these results suggested that HFIP-induced state of BLA represented a molten globule-like state at pH 2.0.

  19. Effects of Grapevine Leafroll associated Virus 3 (GLRaV-3) and duration of infection on fruit composition and wine chemical profile of Vitis vinifera L. cv. Sauvignon blanc.

    Science.gov (United States)

    Montero, R; Mundy, D; Albright, A; Grose, C; Trought, M C T; Cohen, D; Chooi, K M; MacDiarmid, R; Flexas, J; Bota, J

    2016-04-15

    In order to determine the effects of Grapevine Leafroll associated Virus 3 (GLRaV-3) on fruit composition and chemical profile of juice and wine from Vitis vinifera L. cv. Sauvignon blanc grown in New Zealand, composition variables were measured on fruit from vines either infected with GLRaV-3 (established or recent infections) or uninfected vines. Physiological ripeness (20.4°Brix) was the criterion established to determine the harvest date for each of the three treatments. Date of grape ripeness was strongly affected by virus infection. In juice and wine, GLRaV-3 infection prior to 2008 reduced titratable acidity compared with the uninfected control. Differences observed in amino acids from the three infection status groups did not modify basic wine chemical properties. In conclusion, GLRaV-3 infection slowed grape ripening, but at equivalent ripeness to result in minimal effects on the juice and wine chemistry. Time of infection produced differences in specific plant physiological variables. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Brief communication: 3-D reconstruction of a collapsed rock pillar from Web-retrieved images and terrestrial lidar data - the 2005 event of the west face of the Drus (Mont Blanc massif)

    Science.gov (United States)

    Guerin, Antoine; Abellán, Antonio; Matasci, Battista; Jaboyedoff, Michel; Derron, Marc-Henri; Ravanel, Ludovic

    2017-07-01

    In June 2005, a series of major rockfall events completely wiped out the Bonatti Pillar located in the legendary Drus west face (Mont Blanc massif, France). Terrestrial lidar scans of the west face were acquired after this event, but no pre-event point cloud is available. Thus, in order to reconstruct the volume and the shape of the collapsed blocks, a 3-D model has been built using photogrammetry (structure-from-motion (SfM) algorithms) based on 30 pictures collected on the Web. All these pictures were taken between September 2003 and May 2005. We then reconstructed the shape and volume of the fallen compartment by comparing the SfM model with terrestrial lidar data acquired in October 2005 and November 2011. The volume is calculated to 292 680 m3 (±5.6 %). This result is close to the value previously assessed by Ravanel and Deline (2008) for this same rock avalanche (265 000 ± 10 000 m3). The difference between these two estimations can be explained by the rounded shape of the volume determined by photogrammetry, which may lead to a volume overestimation. However it is not excluded that the volume calculated by Ravanel and Deline (2008) is slightly underestimated, the thickness of the blocks having been assessed manually from historical photographs.

  1. PENGARUH KOMPOSOSI LAPISAN PADA PERMUKAAN GLOBULA MINYAK EMULSI SEBELUM PENGERINGAN SEMPROT TERHADAP SIFAT-SIFAT MIKROKAMSUL TRIGLISERIDA KAYA ASAM LEMAK W-3 [The Effect of the Composition of Adsorbed Layer at Globule Interface of -3 Fatty Acids Enriched Triglyceride Prior to Spray Drying on its Microcapsule Properties

    Directory of Open Access Journals (Sweden)

    Moch Adnan2

    2005-04-01

    Full Text Available Emulsification is the critical factor in microencapsulation by spray drying method. Sodium caseinate is a protein with good emulsifying properties. The properties could be improved by phospholipids addition in the emulsification. Phospholipids addition which stabilized oil globule might change the composition of adsorbed layer.This research was conducted to analyze the changes in composition at oil globule interface by analyzing emulsion systems of triglyceride enriched by -3 fatty acids at 5% (w/v stabilized by sodium caseinate (10% w/v and addition of phospholipids at 0; 0,5; 1,0; 1,5; 2,0; and 2,5% (w/v. The changes in composition of adsorbed layer could be determined from the changes in phospholipids and adsorbed protein concentrations at oil globule interface. Analyses were done to measure the possibility of casein-phospholipids complex, phospholipids and protein adsorption concentration at interface, and adsorbed protein.The increase of phospholipids concentration in the emulsions stabilized by sodium caseinate changed the composition of adsorbed layer at interface. There was phospholipids increase and adsorbed protein decrease at oil globule interface. These changes were caused by casein-phospholipids complex which that decreased surface activity and displacement protein by phospholipids that was adsorbed at oil globule interface.Changes of composition of casein-phospholipids at oil globule prior to microcapsulation process caused changes in the properties of microcapsule produced. The increasing phospholipids and decreasing casein concentrations at oil globule interface decreased the quality of the microcapsule, including decreasing in microencapsulation efficiency, in oxidative stability, and decreasing in EPA+DHA content.

  2. Possible uses of satellite remote sensing in agrometeorology; Possibilités d'utilisation de la télédétection satellitaire en agrométéorologie

    Energy Technology Data Exchange (ETDEWEB)

    Guyot, G.; Seguin, B.

    1988-07-01

    Remote sensing offers new possibilities in agrometeorology. Meteorological satellites (which have good revisit capability but low spatial resolution) and earth observation satellites (which have good spatial resolution but poor revisit capability) give complementary information on crop growth conditions and on the biological status of plants. Thermal infrared data can be used to map local climates, to estimate water balance at the scale of a small region and to determine the extent and the seriousness of damage caused by major climatic accidents (frost, drought). Visible near, near and middle infrared data are well adapted to crop identification and monitoring, biomass estimation and yield forecasting. The combination of information given by these 2 types of satellites should in future provide better knowledge and better control of agricultural production. However the application of such techniques may be limited by the cloud cover [French] La télédétection offre des possibilités nouvelles dans le domaine de l’agrométéorologie. Les satellites météorologiques (qui ont une bonne répétitivité dans le temps mais une faible résolution spatiale) et les satellites d’observation de la terre (qui ont une bonne résolution spatiale mais une faible répétitivité dans le temps) permettent d’obtenir des informations complémentaires sur les conditions dans lesquelles se développent les cultures et sur leur état. Les données de l’infrarouge thermique peuvent être utilisées pour cartographier les climats locaux, estimer les bilans hydriques à l’échelle de la petite région et déterminer l’extension spatiale et l’ampleur des accidents climatiques majeurs (gel, sécheresse). Les données du visible, du proche et du moyen infrarouge permettent d’identifier les cultures, de déterminer leur stade phénologique, de suivre leur évolution, d’estimer leur biomasse et de prévoir leur production. La combinaison des informations fournies par ces 2

  3. Study of a novel agent for TCA precipitated proteins washing - comprehensive insights into the role of ethanol/HCl on molten globule state by multi-spectroscopic analyses.

    Science.gov (United States)

    Eddhif, Balkis; Lange, Justin; Guignard, Nadia; Batonneau, Yann; Clarhaut, Jonathan; Papot, Sébastien; Geffroy-Rodier, Claude; Poinot, Pauline

    2018-02-20

    Sample preparation for mass spectrometry-based proteomics is a key step for ensuring reliable data. In gel-free experimental workflows, protein purification often starts with a precipitation stage using trichloroacetic acid (TCA). In presence of TCA, proteins precipitate in a stable molten globule state making the pellet difficult to solubilize in aqueous buffer for proteolytic digestion and MS analysis. In this context, the objective of this work was to study the suitability of a novel agent, ethanol/HCl, for the washing of TCA-precipitated proteins. This method optimized the recovery of proteins in aqueous buffer (50 to 96%) while current organic solvents led to losses of material. Following a mechanistic study, the effect of ethanol/HCl on the conformation of TCA-precipitated proteins was investigated. It was shown that the reagent triggered the unfolding of TCA-stabilized molten globule into a reversible intermediate, characterized by a specific Raman signature, which favored protein subsequent resolubilization. Finally, the efficiency of ethanol/HCl for the washing of TCA-precipitated proteins extracted from a biofilm, a soil or a mouse liver was demonstrated (data available via ProteomeXchange with identifier PXD008110). Being versatile and simple, it could be of great interest to include an ethanol/HCl wash-step to produce high-quality protein extracts. In mass spectrometry-based proteomics workflows, proteins precipitation and/or washing usually involves the use of acetone. In fact, this solvent is effective for removing both biological interferences (e.g. lipids) and chemicals employed in protein extraction/purification protocols (e.g. TCA, SDS). However, the use of acetone can lead to significant protein losses. Moreover, when proteins are precipitated with TCA, the acetone-treated precipitate remains hard to disperse, leading to poor resolubilization of proteins in aqueous buffers. Here, we investigated the use of ethanol/HCl for washing TCA

  4. Nèg Blanc sa a (Aquela negra branca – desafiando as categorias de cor, nacionalidade e pertença a partir de um olhar afro-brasileiro sobre o Haiti

    Directory of Open Access Journals (Sweden)

    Renata de Melo Rosa

    2016-11-01

    Full Text Available Resumo  Este artigo tem como objetivo analisar a centralidade da categoria de pessoa no Haiti contemporâneo, a qual se funda a partir dos sentidos contextuais atribuídos à noção de nèg, (que em tradução livre para o português pode ser entendida como “negro/a” que antecede e funda, ao mesmo tempo, a categoria de pessoa. No entanto, mesmo que a categoria de pessoa no Haiti se ancore em uma nomenclatura “racial”, nèg não é uma categoria necessariamente atrelada à cor da pele, mas à qualidade da pertença de cada sujeito à nação haitiana. Identificar-se e ser identificado como um “nèg” atualiza, no processo identitário e no diálogo inter-subjetivo, diacríticos importantes, cujos sentidos são dados coletiva e contextualmente na rede de significados tecidas no contexto haitiano. Assim, pela natureza contextual e por sua constante dinâmica, é possível que uma “pessoa” que, aos olhos ocidentais, possa se assemelhar com o que nós entendemos como um/a “negro/a” no Brasil, no Haiti esta mesma “pessoa” pode não estar imediatamente identificada como um nèg ou como uma pessoa que  “pertença” ao Haiti. Em outras palavras, é preciso que cada nèg (para continuar sendo nèg e, portanto, “pessoa” atualize, de acordo com os contornos da cultura haitiana que inscrevem um nèg, as diversas obrigações rituais de pertença a esta categoria. Vista desta perspectiva, a categoria nèg pode ser ritualizada por um (a haitiano (a branco (a, desde que os rituais de pertença à nação também sejam atualizados, tornando o sujeito em um (a Nég Blanc (negro branco, expressão que dá título a este artigo. Por último, esta reflexão propõe que a categoria nèg como sinônimo da categoria de pessoa é uma contra narrativa às tentativas de inferiorização racial vigentes no período colonial francês. Palavras chave: nèg; noção de pessoa; Haiti; nação, categorias de cor. Nèg Blanc sa a (Aquella negra

  5. Milk fat globule membrane supplementation with voluntary running exercise attenuates age-related motor dysfunction by suppressing neuromuscular junction abnormalities in mice.

    Science.gov (United States)

    Yano, Michiko; Minegishi, Yoshihiko; Sugita, Satoshi; Ota, Noriyasu

    2017-10-15

    Age-related loss of skeletal muscle mass and function attenuates physical performance, and maintaining fine muscle innervation is known to play an important role in its prevention. We had previously shown that consumption of milk fat globule membrane (MFGM) with habitual exercise improves the muscle mass and motor function in humans and mice. Improvement of neuromuscular junction (NMJ) was suggested as one of the mechanisms underlying these effects. In this study, we evaluated the effect of MFGM intake combined with voluntary running (MFGM-VR) on morphological changes of NMJ and motor function in aging mice. Seven months following the intervention, the MFGM-VR group showed a significantly improved motor coordination in the rotarod test and muscle force in the grip strength test compared with the control group at 13 and 14months of age, respectively. In 14-month old control mice, the extensor digitorum longus muscle showed increased abnormal NMJs, such as fragmentation and denervation, compared with 6-month old young mice. However, such age-related deteriorations of NMJs were significantly suppressed in the MFGM-VR group. Increase in the expression of NMJ formation-related genes, such as agrin and LDL Receptor Related Protein 4 (LRP4), might contribute to this beneficial effect. Rotarod performance and grip strength showed significant negative correlation with the status of denervation and fragmentation of NMJs. These results suggest that MFGM intake with voluntary running exercise effectively suppresses age-related morphological deterioration of NMJ, thus contributing to improvement of motor function. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  6. Milk fat globule membrane coating of large lipid droplets in the diet of young mice prevents body fat accumulation in adulthood.

    Science.gov (United States)

    Baars, Annemarie; Oosting, Annemarie; Engels, Eefje; Kegler, Diane; Kodde, Andrea; Schipper, Lidewij; Verkade, Henkjan J; van der Beek, Eline M

    2016-06-01

    Epidemiological studies have demonstrated protective effects of breast-feeding on childhood obesity. Differences between human milk and infant milk formula (IMF) in dietary lipid structure may contribute to this effect. In our mouse model, feeding a diet containing large lipid droplets coated with phospholipids (PL) (Nuturis®; PL of milk fat globule membrane (MFGM) fraction origin) in early life protected against excessive body fat accumulation following a diet challenge in adult life. We now set out to determine the relevance of increased droplet size and/or MFGM lipid droplet coating to the observed anti-obesogenic effects in adult life. From day 16 to 42, male mouse pups were exposed to diets with small (S) or large (L) lipid droplets (0·3 v. 2·9 µm average mode diameter, respectively), either without MFGM or with MFGM coating around the lipid droplet, resulting in four groups: S (control diet), L, Scoating and Lcoating (Nuturis® IMF diet). Mice were subsequently challenged with a Western-style diet until dissection at postnatal day 98. A non-challenged group served as reference (REF). We repeatedly determined body composition between postnatal day 42 and 98. At day 98 plasma and gene expression measurements were performed. Only the Nuturis® IMF diet (Lcoating) in early life containing MFGM-coated large lipid droplets reduced body fat mass to a level comparable with the REF group. These data support the notion that the structural aspects of lipids in human milk, for example, both lipid droplet size as well as the MFGM coating, may contribute to its reported protective effect against obesity in later life.

  7. Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.

    Science.gov (United States)

    Pedrote, Murilo M; de Oliveira, Guilherme A P; Felix, Adriani L; Mota, Michelle F; Marques, Mayra de A; Soares, Iaci N; Iqbal, Anwar; Norberto, Douglas R; Gomes, Andre M O; Gratton, Enrico; Cino, Elio A; Silva, Jerson L

    2018-05-31

    The functionality of the tumor suppressor p53 is altered in more than 50% of human cancers, and many individuals with cancer exhibit amyloid-like buildups of aggregated p53. An understanding of what triggers the pathogenic amyloid conversion of p53 is required for the further development of cancer therapies. Here, perturbation of the p53 core domain (p53C) with sub-denaturing concentrations of guanidine hydrochloride and high hydrostatic pressure revealed native-like molten globule (MG) states, a subset of which were highly prone to amyloidogenic aggregation. We found that MG conformers of p53C, likely representing population-weighted averages of multiple states, have different volumetric properties, as determined by pressure perturbation and size-exclusion chromatography. We also found that they bind the fluorescent dye 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (bis-ANS) and have a native-like tertiary structure that occludes the single Trp residue in p53. Fluorescence experiments revealed conformational changes of the single Trp and Tyr residues before p53 unfolding and the presence of MG conformers, some of which were highly prone to aggregation. P53C exhibited marginal unfolding cooperativity, which could be modulated from unfolding to aggregation pathways with chemical or physical forces. We conclude that trapping amyloid precursor states in solution is a promising approach for understanding p53 aggregation in cancer. Our findings support the use of single-Trp fluorescence as a probe for evaluating p53 stability, effects of mutations, and the efficacy of therapeutics designed to stabilize p53. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Entraînement de globules d'huile par un tensio-actif. Etude de la formation du banc Mobilization of Oil Ganglia by a Surfactant Analysis of Bank Formation

    Directory of Open Access Journals (Sweden)

    Moulu J. C.

    2006-11-01

    Full Text Available Lors de l'injection d'une solution de tensio-actif dans un gisement déjà balayé par de l'eau, l'huile résiduelle, piégée sous la forme de globules discontinus, est remise en mouvement et se regroupe éventuellement sous la forme d'un banc d'huile. Le but de la présente étude est d'expliquer la formation de ce banc au cours d'un tel déplacement. Les résultats d'expériences réalisées en micromodèles de billes de verre permettent de constater que : - la récupération globale est corrélable avec le nombre capillaire Nc= uVdf/O, u et Vdf étant la viscosité et la vitesse de Darcy du fluide injecté, O la tension interfaciale avec l'huile en place ; - la vitesse des globules varie différemment avec u, Vdf, O et tend vers la même limite plus grande que la vitesse du fluide injecté pour de grandes valeurs du nombre capillaire Nc ; - le banc d'huile ne se forme que dans le cas où la vitesse des globules atteint celle du fluide injecté. L'huile déplacée reste alors groupée avec une saturation importante au niveau du front de tensio-actif. When a surfactant solution is injected into a reservoir previously waterflooded, the residual oil trapped as discontinuous ganglia is mobilized and eventually bunched together forming an oil bank. The aim of this study is to explain the formation of this bank during such a drive. The results of experiments performed in micromodels of glass beads show that: a Overall recovery can be correlated with the capillary number, Nc = uVfd/O, in which u and Vfd are the viscosity a and Darcy velocity of the injected fluid and O is the interfacial tension with the oil in place. b Ganglia velocity varies differently with u, Vfd and O, and it tends towards the same limit faster than the velocity of the injected fluid for high values of the capillary number Nc. c The oil bank is formed only in the case where globule velocity attaints that of injected fluid. the dispaced oil then remains bunched, with high

  9. Imaging of non-small cell lung cancers with a monoclonal antibody, KC-4G3, which recognizes a human milk fat globule antigen

    International Nuclear Information System (INIS)

    Dienhart, D.G.; Schmelter, R.F.; Lear, J.L.; Miller, G.J.; Glenn, S.D.; Bloedow, D.C.; Kasliwal, R.; Moran, P.; Seligman, P.; Murphy, J.R.

    1990-01-01

    To determine the role of lung cancer tumor imaging with monoclonal antibodies directed against high molecular weight human milk fat globule antigens, we administered i.v. 111In-KC-4G3 to 24 patients with advanced non-small cell lung cancer. One mg of 111In-KC-4G3 was mixed with 0, 9, 49, 99, or 499 mg of unlabeled KC-4G3 and infused i.v. over 1 to 5 h. The mean 111In-KC-4G3 radiochemical purity was greater than 97% and the resultant immunoreactivity averaged 62%. Successful imaging of cancer sites was accomplished in 92% of 24 patients, and 57% of 91 total lesions were visualized. Successful localization of tumor sites related to size (P less than 0.001), with 81% of lesions greater than 3.0 cm in diameter, 50% of lesions 1.5 to 3 cm, and 6% of lesions less than 1.5 cm successfully imaging, and to location (P less than 0.05), with 69% of pulmonary lesions, 80% of soft tissue lesions, and only 32% of bone metastases being visualized. Nonspecific reticulo-endothelial uptake of radioactivity was a major problem. Approximately 35% of 111In was chelated to serum transferrin by 24 and 48 h after infusion. The mean t 1/2 beta for plasma radioisotope and immunoreactive KC-4G3 was 29 and 27 h, respectively. There was no correlation between total infused antibody dose and imaging success or between total dose and effect on 111In and KC-4G3 kinetics. Circulating free KC-4 antigen was measurable in all but one patient before study. Tumor biopsy following infusion could demonstrate antibody presence but not saturable antigen binding. We conclude that (a) 111In-KC-4G3 demonstrates successful tumor localization in non-small cell lung cancers bearing generally high expression of its antigen and (b) further investigations to diminish nonspecific radioactivity for imaging and utilization of high dose radiolabeled antibody for therapeutic intent are warranted

  10. Milk fat globule-epidermal growth factor-factor VIII-derived peptide MSP68 is a cytoskeletal immunomodulator of neutrophils that inhibits Rac1.

    Science.gov (United States)

    Hendricks, Louie; Aziz, Monowar; Yang, Weng-Lang; Nicastro, Jeffrey; Coppa, Gene F; Symons, Marc; Wang, Ping

    2017-02-01

    Prolonged neutrophil infiltration leads to exaggerated inflammation and tissue damage during sepsis. Neutrophil migration requires rearrangement of their cytoskeleton. Milk fat globule-epidermal growth factor-factor VIII-derived short peptide 68 (MSP68) has recently been shown to be beneficial in sepsis-induced tissue injury and mortality. We hypothesize that MSP68 inhibits neutrophil migration by modulating small GTPase Rac1-dependent cytoskeletal rearrangements. Bone marrow-derived neutrophils (BMDNs) or whole lung digest isolated neutrophils were isolated from 8 to 10 wk old C57BL/6 mice by Percoll density gradient centrifugation. The purity of BMDN was verified by flow cytometry with CD11b/Gr-1 staining. Neutrophils were stimulated with N-formylmethionine-leucine-phenylalanine (f-MLP) (10 nM) in the presence or absence of MSP68 at 10 nM or cecal ligation and puncture (CLP) was used to induce sepsis, and MSP68 was administered at 1 mg/kg intravenously. Cytoskeletal organization was assessed by phalloidin staining, followed by analysis using fluorescence microscopy. Activity of the Rac1 GTPase in f-MLP or CLP-activated BMDN in the presence or absence of MSP68 was assessed by GTPase enzyme-linked immunosorbent assay. Mitogen-activated protein (MAP) kinase activity was determined by western blot densitometry. BMDN treatment with f-MLP increased cytoskeletal remodeling as revealed by the localization of filamentous actin to the periphery of the neutrophil. By contrast, cells pretreated with MSP68 had considerably reduced filamentous actin polymerization. Cytoskeletal spreading is associated with the activation of the small GTPase Rac1. We found BMDN-treated with f-MLP or that were exposed to sepsis by CLP had increased Rac1 signaling, whereas the cells pretreated with MSP68 had significantly reduced Rac1 activation (P Rac1-MAP kinase-mediated neutrophil motility. Thus, MSP68 is a novel therapeutic candidate for regulating inflammation and tissue damage caused

  11. Localization of a membrane glycoprotein in benign fibrocystic disease and infiltrating duct carcinomas of the human breast with the use of a monoclonal antibody to guinea pig milk fat globule membrane.

    Science.gov (United States)

    Greenwalt, D. E.; Johnson, V. G.; Kuhajda, F. P.; Eggleston, J. C.; Mather, I. H.

    1985-01-01

    With monoclonal antibody D-274, raised against guinea pig milk fat globule membrane, the distribution of mucinlike glycoproteins of Mrs greater than or equal to 400,000 was determined in benign fibrocystic disease and infiltrating duct carcinoma of the human breast. These glycoproteins, called collectively PAS-I, were detected in 19 out of 20 cases of benign fibrocystic disease and in at least 26 out of 47 cases of infiltrating duct carcinoma. PAS-I was concentrated on luminal surfaces of ducts and alveoli in morphologically differentiated regions of the tumors. In areas where the glandular nature of the tissue was less evident in infiltrating duct carcinoma, the PAS-I determinant recognized by antibody D-274 was present on irregular luminal surfaces and in the cytoplasm. There was a negative correlation between the short-term recurrence (less than 2 years) of infiltrating duct carcinoma and the detection of strong positive staining with antibody D-274. The results are discussed with reference to recent studies on PAS-I in human breast tissue using monoclonal antibodies raised against human milk fat globule membrane. Images Figure 1 Figure 2 Figure 3 PMID:2579563

  12. On the Waste Disposal Potentiality of the Atmosphere; Possibilites d'Elimination des Dechets Radioactifs dans l'Atmosphere; 041a 0412 041e 041f 0414 ; Sobre la Posibilidad de Evacuar Desechos en la Atmosfera

    Energy Technology Data Exchange (ETDEWEB)

    Small, S. H.; Storebo, P. B. [Norwegian Defence Research Establishment (Norway)

    1960-07-01

    The whole scale of atmospheric mixing, transport and removal processes is reviewed. Certain measurements indicate replacement of stratospheric air within about two years, making high-altitude disposal of radioactive waste materials even less attractive than earlier assumed. Deposition of radioactive materials is to some extent systematically non-uniform, and permissible levels of atmospheric radioactivity should be based upon the probable hazards in the most exposed regions, e.g. regions of considerable orographic precipitation. In connexion with the measurement of atmospheric radioactivity, it is pointed out that sampling techniques should cover the probable effects of gradual changes in particle sizes, and removal of particles by settling, impingement and absorption on vegetation and buildings etc. Meteorological problems in connexion with radiation monitoring and warning systems are discussed in relation to reactor operations. Technical details of relatively simple warning systems are given. (author) [French] Les auteurs examinent l'ensemble des processus suivant lesquels les dechets radioactifs sont brasses, transportes et disperses dans les couches atmospheriques. Certaines mesures indiquent que le renouvellement des masses d'air stratospheriques se fait' en moins de deux ans environ; la possibilite d'eliminer les dechets radioactifs dans les couches superieures de l'atmosphere semble donc encore moins seduisante qu'elle ne le paraissait tout d'abord. On peut dire que, dans une certaine mesure, le depot des substances radioactives s'effectue systematiquement de facon non uniforme; pour determiner le taux de radioactivite atmospherique admissible, il faut donc se baser sur les risques probables encourus dans les regions les plus exposees, par exemple dans les regions a fortes precipitations orographiques. En ce qui concerne la mesure de la radioactivite atmospherique, les techniques d'echantillonnage devraient tenir compte des consequences probables de la

  13. Nota biobibliográfica + poética + creaciones («Rebel·lió: problema visual», «Tarot de Marsella: poema aleatorio», «Codex mundi. Contingencia: escritura fractal II-3», «Blanc o nada. Topoemalogía (trilingüe», «New York, Portbou, Benjamin» y «Bar 12 heures

    Directory of Open Access Journals (Sweden)

    Ramon Dachs

    2014-03-01

    Full Text Available Nota biobibliográfica + poética + creaciones («Rebel·lió: problema visual», «Tarot de Marsella: poema aleatorio», «Codex mundi. Contingencia: escritura fractal II-3», «Blanc o nada. Topoemalogía (trilingüe», «New York, Portbou, Benjamin» y «Bar 12 heures» + cuestionario (Victoria Pineda

  14. Diez portainjertos de vid: Efectos sobre el crecimiento, la producción y la composición de la uva del cv. Sauvignon blanc en la denominación de origen rueda (España

    Directory of Open Access Journals (Sweden)

    Yuste Jesus

    2017-01-01

    Full Text Available The knowledge of the behaviour of different grapevine rootstocks is basic to achieve a good adaptation of vine to its growing area. With the objective of knowing the agronomic and qualitative response of cv. Sauvignon Blanc to the use of several rootstocks, a trial was established in 2006 in the D.O. Rueda. The vines are vertical trellised, with bilateral Royat cordon pruning, and the vine spacing is 2.60 m × 1.25 m. The row orientation is NNW (N-25°. The experimental design consisted of randomized blocks with 4 replications and elemental plot of 60 vines. Over the period 2010–2014 it has been developed the study of the following 10 rootstocks (treatments: 110R, 101-14M, 420A, 3309C, 41B, 161-49C, 196-17C, Fercal, Gravesac and RGM. The rootstocks 420A and 41B showed a production higher than 50% with respect to 196-17C and 161-49C, and higher to 100% than RGM, due to the number of clusters per vine and, in greater amount, to the cluster weight. Fercal and Gravesac showed an increase of pruning wood weight of 24% with respect to 196-17C and 161-49C, and 90% with respect to RGM, mainly due to the shoot weight. The sugar concentration increased with 101-14M, 196-17C and Fercal, and became reduced with 161-49C, 41B and RGM. The pH of must was reduced with Fercal whereas the titratable acidity increased, which also showed increase with Gravesac and 161-49C. The tartaric acid hardly increased slightly with Fercal and 161-49C, whereas the malic acid increased with Gravesac and Fercal, and was reduced with 41B, 3309C, RGM and 101-14M. The potassium concentration increased with 196-17C, Gravesac and Fercal, and was reduced with 41B, 161-49C, 420A and 3309C. The effects observed show alternatives for rootstock election according to the growing conditions and objectives of the vineyard.

  15. The Italian drilling project of the Mont Blanc road tunnel in the late fifties: an example of no geological care and lack of ethics in carrying out a big work.

    Science.gov (United States)

    Gosso, Guido; Croce, Giuseppe; Matteucci, Ruggero; Peppoloni, Silvia; Piacente, Sandra; Wasowski, Janusz

    2013-04-01

    In the first decade after the Second World War Italy was rushing to recover a positive role among European countries; basic needs as road communications with European neighbours became main priorities. The necessity of a rapid connection with South-eastern France, a subject already debated between the two nations over more than 50 years, appeared then on first line; the two countries convened on a joint investment for the construction of a tunnel across the international border of Mont Blanc, along the shortest track between Courmayeur and Chamonix. The political agreements were in favour of the quickest start of the drilling operations and such obligation imposed on the Italian side an impoverishment of the project content, specially concerning geological issues. No surveys were performed on fracture systems, cataclastic zones and faults, on the few rock ridges standing above the tunnel line and outcropping through thick talus cones, moraines, ice tongues and their related ice plateaus. Metasediments, migmatites and poorly foliated granites were to be drilled. Three Italian academics were allowed by the drilling company to track the working progress and collect rocks for comparison with other Alpine types; they mapped the lithology and the fault zonesall along the freshly excavated tunnel; the results of such survey appeared after the end of works. Geologists from Florence University published the surface granite faulting pattern 20 years after the road tunnel became operative. Such geological cares could have located the risky zones in time for the tunnel project, mitigating the catastrophic effects of sudden drainage of subglacial water from the Vallée Blanche ice plateau (Ghiacciaio del Gigante) at progression 3800m, that caused dramatic accidents and affected negatively the economy of the drilling. Also the wallrock temperature drops, measured during the drill, should have warned the company management on the location of dangerous fracture zones. Anxiety of

  16. ETUDE DE L'EFFET DE QUELQUES FACTEURS SUR LA CYTOTOXICITE INDUITE PAR L'AMPHOTERICINE B ASSOCIEE AUX LIPOPROTEINES DU SERUM SANGUIN CHEZ DES CELLULES DE GLOBULES ROUGES HUMAINES

    OpenAIRE

    BOUCHERIT, ATMANI Zahia

    2014-01-01

    toxiques. Dans le cadre de l'élaboration d'une stratégie de développement de cette molécule visant à augmenter l'index thérapeutique tout en réduisant la toxicité, nous avons étudié l'effet de quelques facteurs sur la cytotoxicité induite par l'amphotéricine B associée à des lipoprotéines du sérum sanguin chez le globule rouge humain (modèle universel de cellules animales supérieures). Dans notre travail nous avons abordé d'une part, les effets des caractéristiques des lipoprot...

  17. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial.

    Science.gov (United States)

    Timby, Niklas; Domellöf, Erik; Hernell, Olle; Lönnerdal, Bo; Domellöf, Magnus

    2014-04-01

    Observational studies have indicated that differences in the composition of human milk and infant formula yield benefits in cognitive development and early growth for breastfed infants. The objective was to test the hypothesis that feeding an infant formula with reduced energy and protein densities and supplemented with bovine milk fat globule membrane (MFGM) reduces differences in cognitive development and early growth between formula-fed and breastfed infants. In a prospective, double-blind, randomized controlled trial, 160 infants Toddler Development, Third Edition, was significantly higher in the EF group than in the SF group (105.8 ± 9.2 compared with 101.8 ± 8.0; P = 0.008) but was not significantly different from that in the BFR group (106.4 ± 9.5; P = 0.73). The EF group ingested larger volumes of formula than did the SF group (864 ± 174 compared with 797 ± 165 mL/d; P = 0.022), fully compensating for the lower energy density. No significant differences in linear growth, weight gain, body mass index, percentage body fat, or head circumference were found between the EF and SF groups. MFGM supplementation to infant formula narrows the gap in cognitive development between breastfed and formula-fed infants. Between 2 and 6 mo of age, formula-fed term infants have the capacity to upregulate their ingested volumes when the energy density of formula is reduced from 66 to 60 kcal/100 mL.

  18. 子宮水腫 (Hydrometra) を呈した沖縄肉用ヤギの子宮内膜上皮における Globule Leucocytes の出現(生産環境学科)

    OpenAIRE

    川島, 由次; 仲田, 正; 古謝, 治; 古謝, 瑞幸; Kawashima, Yoshitsugu; Nakada, Tadashi; Koza, Osamu; Koza, Zuiko

    1993-01-01

    子宮水腫を呈した沖縄肉用ヤギの子宮内膜上皮に出現するGlobule Leucocytes(GL)について光顕並びに電顕による観察とその出現原因についての考察を行った。GLは直径13.8μm,短径7.6μmで,円形ないし卵円形を呈し,核は円形で,細胞質内に偏在した。顆粒は円形で,直径が平均1.8μmで,その数はGL1個当り3.4個であった。顆粒は塩基性フクシン・メチレンブルー重染色により赤色と青色に染色された。子宮水腫症ヤギの卵巣には妊娠ヤギとほぼ同じ大きさの機能黄体が存在していることから,同症ヤギのGL出現はこの黄体から分泌される黄体ホルモン(Progesterone)と関連していると思われる。...

  19. Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor.

    Science.gov (United States)

    Howangyin, Kiave-Yune; Zlatanova, Ivana; Pinto, Cristina; Ngkelo, Anta; Cochain, Clément; Rouanet, Marie; Vilar, José; Lemitre, Mathilde; Stockmann, Christian; Fleischmann, Bernd K; Mallat, Ziad; Silvestre, Jean-Sébastien

    2016-03-01

    In infarcted heart, improper clearance of dying cells by activated neighboring phagocytes may precipitate the transition to heart failure. We analyzed the coordinated role of 2 major mediators of efferocytosis, the myeloid-epithelial-reproductive protein tyrosine kinase (Mertk) and the milk fat globule epidermal growth factor (Mfge8), in directing cardiac remodeling by skewing the inflammatory response after myocardial infarction. We generated double-deficient mice for Mertk and Mfge8 (Mertk(-/-)/Mfge8(-/-)) and challenged them with acute coronary ligature. Compared with wild-type, Mertk-deficient (Mertk(-/-)), or Mfge8-deficient (Mfge8(-/-)) animals, Mertk(-/-)/Mfge8(-/-) mice displayed greater alteration in cardiac function and remodeling. Mertk and Mfge8 were expressed mainly by cardiac Ly6C(High and Low) monocytes and macrophages. In parallel, Mertk(-/-)/Mfge8(-/-) bone marrow chimeras manifested increased accumulation of apoptotic cells, enhanced fibrotic area, and larger infarct size, as well as reduced angiogenesis. We found that the abrogation of efferocytosis affected neither the ability of circulating monocytes to infiltrate cardiac tissue nor the number of resident Ly6C(High) and Ly6C(How) monocytes/macrophages populating the infarcted milieu. In contrast, combined Mertk and Mfge8 deficiency in Ly6C(High)/Ly6C(Low) monocytes/macrophages either obtained from in vitro differentiation of bone marrow cells or isolated from infarcted hearts altered their capacity of efferocytosis and subsequently blunted vascular endothelial growth factor A (VEGFA) release. Using LysMCre(+)/VEGFA(fl/fl) mice, we further identified an important role for myeloid-derived VEGFA in improving cardiac function and angiogenesis. After myocardial infarction, Mertk- and Mfge8-expressing monocyte/macrophages synergistically engage the clearance of injured cardiomyocytes, favoring the secretion of VEGFA to locally repair the dysfunctional heart. © 2016 The Authors.

  20. Résultats de recherche | Page 35 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les lymphocytes B, un type de globules blancs du système immunitaire, produisent et exportent des anticorps qui cherchent des microbes et des toxines, s'y fixent et les neutralisent. Projet. -. Améliorer l'immunité innée des macrophages par la modulation des protéines tyrosine phosphatases : recensement complet des ...

  1. Etude des possibilites de contamination des aliments de rues au ...

    African Journals Online (AJOL)

    Foods poisoning due to microbial toxins are widespread throughout the world. These foods poisoning are prevalent in African countries were street alimentation enable 80% of urban populations to feed themselves easily and at lower price. The street foods constitute a major public health problem because of the multiplicity ...

  2. BLACK SEA YAHTING: POSSIBILITES AND LIMITATIONS OF DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Viktor Selivanov

    2016-04-01

    Full Text Available The article discusses some of the issues associated with the international practice of registration of foreign-yacht in the Black Sea ports of Russia. The development of nautical tourism in the Republic of the Crimea is given special attention. Russian Government is developing a program of creation of favorable conditions for development of yachting in the coastal areas of the Russian Federation. However, the legislation of the Russian Federation governing the yachts passing through the state border of the Russian Federation has not yet fully in line with international standards. Therefore, consideration of international practice, foreign-design yacht is relevant for the sustainable development of nautical tourism in the Crimea.

  3. The possibilites of increasing lignan content in food

    Czech Academy of Sciences Publication Activity Database

    Kulichová, J.; Híc, P.; Tříska, Jan; Vrchotová, Naděžda; Houška, M.

    2016-01-01

    Roč. 10, č. 1 (2016), s. 649-655 E-ISSN 1337-0960 R&D Projects: GA MZe QJ1210258 Institutional support: RVO:67179843 Keywords : lignan * polyphenol * antioxidant capacity * soft fruit products Subject RIV: GM - Food Processing

  4. RENEWABLE ENERGY SOURCES IN POLAND - CONDITIONS AND POSSIBILITES OF DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Gawlik, L.; Mokrzycki, E.; Ney, R.

    2007-07-01

    The paper describes the state of the art in renewable energy sources development. The obligation resulting from the membership of Poland in the European Union as well as from other international agreements in the scope of renewable energy sources development are described. The production of electricity, heat and biofuels in Poland is given and the perspectives of development of particular renewable energy sources in Poland are discussed in the view of potential reserves and other constrains. The economic aspects of renewable energy technologies are shown. The environmental pros and cons of biomass energy development are described. Arguments for development of renewable energy sources use are stated: the decrease of dependence from primary energy sources, the decrease the emission of green house gases and the recovery of agricultural regions of the country. In conclusion it is stated that the significance of renewable energy sources in Polish conditions is constrained to local societies. Their development should be adjusted to conditions predominating in a given region and that wider consumption of renewable energy sources should develop in conformity with sustainable development, so it is necessary to reach agreement between local societies, institutions dealing with environment protection and representatives of power sector. (auth)

  5. Effects of exercise and milk fat globule membrane (MFGM supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial.

    Directory of Open Access Journals (Sweden)

    Hunkyung Kim

    Full Text Available To investigate the combined and separate effects of exercise and milk fat globule membrane (MFGM supplementation on frailty, physical function, physical activity level, and hematological parameters in community-dwelling elderly Japanese women.A total of 131 frail, elderly women over 75 years were randomly assigned to one of four groups: exercise and MFGM supplementation (Ex+MFGM, exercise and placebo (Ex+Plac, MFGM supplementation, or the placebo group. The exercise group attended a 60-minute training program twice a week for three months, and the MFGM group ingested 1g of the MFGM supplement in pill form, daily for 3 months. The primary outcome measure was change in frailty status based on Fried's frailty phenotype. Secondary outcome measures included body composition, physical function and hematological parameters, and interview survey components assessing lifestyle factors. Participants were followed for 4 months post-intervention.Significant group × time interactions were observed for usual walking speed (P = 0.005, timed up & go (P<0.001, and insulin-like growth factor-binding protein 3/insulin-like growth factor 1 ratio (P = 0.013. The frailty components revealed that weight loss, exhaustion, low physical activity, and slow walking speed were reversed, but low muscle strength did not significantly changed. Frailty reversal rate was significantly higher in the Ex+MFGM (57.6% than in the MFGM (28.1% or placebo (30.3% groups at post-intervention (χ2 = 8.827, P = 0.032, and at the follow-up was also significantly greater in the Ex+MFGM (45.5% and Ex+Plac (39.4% groups compared with the placebo (15.2% group (χ2 = 8.607, P = 0.035. The exercise+MFGM group had the highest odds ratio (OR for frailty reversal at post-intervention and follow-up (OR = 3.12, 95% confidence interval (CI = 1.13-8.60; and OR = 4.67, 95% CI = 1.45-15.08, respectively.This study suggests that interventions including exercise and nutrition can improve frailty status

  6. Estudo dos fatores impregnação e secagem nas características de glóbulos utilizados em homeopatia Study of impregnation and drying factors in the characteristics of globules used in homeopathy

    Directory of Open Access Journals (Sweden)

    Eliana E. Diehl

    2008-03-01

    Full Text Available Glóbulos são uma das formas farmacêuticas mais dispensadas em farmácias homeopáticas no Brasil. Este trabalho teve como objetivo comparar técnicas de impregnação especificadas na Farmacopéia Homeopática Brasileira 2ª Edição e Manual de Normas Técnicas para Farmácia Homeopática 3ª Edição e na prática em farmácias homeopáticas do município de Florianópolis, Santa Catarina, Brasil. As variáveis de formulação percentual de insumo ativo (3 e 10% e tipo de impregnação (simples e tríplice e a variável de processo temperatura de secagem (20 e 50ºC foram analisadas através de planejamento fatorial 2³. As respostas estudadas foram o peso antes e após impregnação e o tempo de desagregação. Os resultados mostraram maior diferença de peso com impregnação a 10 % e secagem a 50ºC, independente do tipo de impregnação. O tempo de desagregação não foi influenciado pelas variáveis em estudo (p Globules are one of the most dosage forms dispensed in homeopathic pharmacies in Brazil. This work aimed at comparing different impregnation techniques specified in the Brazilian Homeopathic Pharmacopoeia 2 Edition and Manual of Technical Norms for Homeopathic Pharmacy 3 Edition and the practical in homeopathic pharmacies in the city of Florianópolis, state of Santa Catarina, Brazil. The formulations variables percent active raw material (3 and 10%, impregnation type (simple and triple and the process variable drying temperature (20 and 50ºC were analyzed through a factorial design 2³. The studied answers were the weight before and after the impregnation and time of disaggregation. The results show a larger weight difference with the 10% impregnation and the drying of 50ºC, regardless of the impregnation type. The time of disaggregation wasn't influenced by the studied variables (p < 0.05. The best homogeneity was verified for the formulation with triple impregnation at 10%.

  7. Possibility of using radioactivity control measurements for determining contamination paths in nutritional vectors; Etude des possibilites d'utilisation des resultats de la surveillance de la radioactivite pour la recherche des trajectoires d'evolution de la contamination des vecteurs alimentaires

    Energy Technology Data Exchange (ETDEWEB)

    Garnier, A [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1966-07-01

    The object of the report is to study the possibility of using results of radioactivity controls for determining the paths followed by contamination in nutritional vectors; these are necessary for calculating protection norms. Radioactive contamination of a nutritional vector is expressed in terms of parameters which suggest that a certain number of criteria may be used for choosing the results which are to be exploited. An actual example of a 'vertical' study based on results of measurements made purely for control purposes shows the difficulties which may be encountered. A list of the results obtained by the control networks set up in the Community Countries, either for the atmosphere, for milk, or for other foodstuffs, shows that these networks are not at the present organised in such a way as to make such a study possible. It appears desirable that a large part of the work carried out by the control Services be oriented in such a way as to yield the complementary information required for experimental studies of radioactive contamination transfers. (author) [French] L'objet du rapport est l'examen des possibilites d'utilisation des resultats de la surveillance de la radioactivite pour la recherche des trajectoires d'evolution de la contamination des vecteurs alimentaires, necessaires au calcul des niveaux de protection. La contamination radioactive d'un vecteur alimentaire s'exprime en fonction de parametres, qui suggerent de retenir un certain nombre de criteres pour la selection des resultats a exploiter. Un exemple concret d'etude 'verticale' basee sur des resultats de mesures faites uniquement dans un but de controle met en evidence les difficultes rencontrees. L'inventaire des resultats obtenus par les reseaux de controle des differents Pays de la Communaute, soit pour l'atmosphere, soit pour le lait, soit pour d'autres aliments, montre que ces reseaux ne sont pas actuellement organises de facon a permettre de telles etudes, Il parait souhaitable qu

  8. Managing a Coastal Bluegum (Eucalyptus globules) forest

    Science.gov (United States)

    Ralph S. Osterling

    1983-01-01

    Eucalyptus was thought to be a replacement to oak and other hardwoods for many products. Thousands of acres have been planted and now are in need of management. Management techniques are discussed in context with a coastal stand of approximately 300 acres of mixed aged bluegum. Potential markets are explored.

  9. The Possibility of Making a Quantitative Study of the Precipitin Reaction by Gamma-Radioactive Tracers; Possibilite d'une Etude Quantitative de la Reaction de Precipitation par Marquage a l'Aide d'Emetteurs Gamma; Vozmozhnost' kolichestvennogo opredeleniya reaktsii osazhdeniya s pomoshch'yu gamma-radioaktivnykh indikatorov; Estudio Cuantitativo de la Reaccion de Precipitacion con Ayuda de Indicadores Gamma

    Energy Technology Data Exchange (ETDEWEB)

    Bonev, L.; Todorov, S.; Robev, S. [Nauchno-Issledovatel' skij Institut Radiologii i Radiacionnoj Bezopasnosti, Sofija (Bulgaria)

    1965-10-15

    The paper presents the first results of the quantitative determination of the precipitin reaction (formation of an antigen-antibody complex) by labelling the precipitating components with gamma-radioactive tracers which do not chemically interact with albuminous molecules. As tracers it is possible to use chrome-manganese and nickel-copper compounds, whose tendency to hydrolyze permits the fixation of the radioactive tracer on the antigen and antibody respectively. The radioactivity of the components is determined by a multichannel pulse-height analyser. The results obtained show that the precipitation curve, plotted on the basis of radiometric data, closely corresponds to the curve plotted by the well-known quantitative methods used to determine albumin. The paper discusses the possibilities of using the method described. (author) [French] Les auteurs communiquent les premiers resultats d'une etude quantitative qu'ils ont faite de la reaction de precipitation (formation du complexe antigene-anticorps) en marquant les composants du precipites avec des emetteurs gamma qui ne reagissent pas chimiquement avec les molecules d'albumine. Pour le marquage, on peut utiliser des composes de chrome/manganese ou de fer qui subissent facilement l'hydrolyse et assurent de ce fait la fixation de la substance radioactive sur l'antigene et, partant, sur l'anticorps. La radioactivite des composants est determinee a l'aide d'un selecteur d'amplitudes a plusieurs canaux. Les resultats montrent que la courbe de precipitation obtenue avec les donnees radiometriques concorde parfaitement avec celle que l'on obtient par les methodes quantitatives connues servant au dosage de l'albumine. Les auteurs discutent les possibilites d'application de la methode etudiee. (author) [Spanish] Los autores presentan los primeros resultados de un estudio cuantitativo de la reaccion de precipitacion (formacion del complejo antigeno-anticuerpo) que efectuaron marcando los componentes de precipitacion con

  10. Some Possibilities of Radiation Polymerization from the Gaseous Phase on Solid Bases; Possibilites de polymerisation radiochimique en phase gazeuse sur des lits de matiere solide; O nekotorykh vozmozhnostyakh radiatsionnoj polimerizatsii iz gazovoj fazy na tverdykh podlozhkakh; Perspectivas de la radiopolimerizacion en fase gaseosa sobre lechos de sustancias solidas

    Energy Technology Data Exchange (ETDEWEB)

    Tsetlin, B. L.

    1963-11-15

    The unusual feature of graft polymer synthesis by solid ''bed'' irradiation in the presence of monomer vapours is that the activation centres initiating polymerization are in practice generated only on the bed; transmission of the kinetic chain to the monomer is impeded and new polymer chains grow only under the influence of the solid bed molecular forces. These features of gas phase processes enlarge the scope of the graft polymer technique, making it applicable to inorganic beds and usable in the synthesis of mineral organic products. If stretched synthetic fibres are used as a bed, on the other hand, their orientated macromolecules control the growth of new polymer chains and the graft polymer is formed directly as an orientated structure. Two-component combined fibres are formed as a result and the fibre-bed and ''grafted'' fibre may in appropriate circumstances each display their own particular complex of mechanical properties. (author) [French] La synthese des polymeres greffes par irradiation de ''lits'' de matiere solide en presence de vapeur de monomeres en voie de polymerisation presente les particularites suivantes: les centres actifs qui amorcent la polymerisation ne se forment pratiquement qu'a la surface du ''lit''; le transfertau monomere de la chaine en mouvement est rendu plus difficile; les nouvelles chafnes du polymere se developpent sous l'action unilaterale des forces moleculaires de la surface solide. Ces particularites du processus en phase gazeuse elargissent les possibilites qu'offre la methode de la polymerisation par greffage. La methode peut alors etre egalement appliquee aux lits non organiques et servir a la synthese de composes organomineraux. En revanche, lorsqu'on utilise comme lits des fibres synthetiques allongees, les macromolecules orientees de ces dernieres dirigent la croissance des nouvelles chaines du polymere de sorte que le polymere greffe se forme directement a l'etat oriente. On obtient ainsi des fibres cominees a deux

  11. Modélisation pluie-débit en région tropicale humide : application des réseaux de neurones sur quatre stations hydrométriques du Bandama Blanc (Bada, Marabadiassa, Tortiya et Bou situées au Nord de la Côte d'Ivoire. Thèse de l'Université de Cocody (Côte d'Ivoire, 2007, 219 p.

    Directory of Open Access Journals (Sweden)

    Yao Blaise Koffi

    2009-12-01

    Full Text Available La relation pluie-débit fait l'objet de nombreuses études, à cause de son importance dans la mise en œuvre de nombreux projets de développement. La communauté scientifique, dans le souci de faire face aux problèmes d'eau, tels que les inondations et les sècheresses, utilise différents modèles. Mais ces modèles sont généralement confrontés à la non-linéarité de la relation pluie-débit. Dans le cas du Bandama Blanc, objet de cette étude, cette non-linéarité est accentuée par la présence de plusieurs barrages à vocation agro-pastorale situés dans la partie nord de la zone d'étude et qui utilisent les eaux de ce fleuve. Ce mémoire de thèse traite donc de la modélisation des débits mensuels du Bandama Blanc, aux stations de Bada, Marabadiassa, Tortiya et Bou, à l'aide des réseaux de neurones, déjà éprouvés dans ce contexte de relation non-linéaire. Elle projette de fournir des outils plus robustes aux hydrologues africains pour la simulation et la prévision des débits des rivières jaugées. Pour atteindre cet objectif, deux Perceptrons Multicouches entraînés avec l'algorithme de la rétropropagation de l'erreur ont été construits. Le premier modèle a été utilisé seulement en simulation et le second en simulation et en prévision. Le modèle conceptuel GR2M, a été utilisé pour valider les résultats obtenus avec les réseaux de neurones. Pour cette étude, une importante base de données climatiques (pluie et température et hydrométriques (débits mensuels a été utilisée. Les résultats obtenus sont forts satisfaisants et nettement supérieurs à ceux obtenus avec le modèle conceptuel global GR2M. En effet, les réseaux de neurones parviennent à expliquer plus de 70 % de la variation des débits, avec des coefficients de corrélation de Pearson qui excèdent 0,80. Cependant ces modèles arrivent difficilement à simuler et à faire la prévision des débits extrêmes (étiages et crues,

  12. White book on energies; Livre blanc sur les energies

    Energy Technology Data Exchange (ETDEWEB)

    Fontaine, N

    2003-11-01

    The energy policy in France has to answer two challenges: the first one is the climatic change and the greenhouse effect, the second one is to conceive an energy policy taking into account the evolutions and economical realities. four objectives have to guide the action of the government, the guarantee to the right of access to energy for every citizen, the fight against the climatic warming, the preservation of a national independence, the keeping of a competitive energy. This book includes a summary of works and conclusions of the National Debate on energies, hold during the first semester of 2003, the government propositions, a whole of cards detailing some aspects of government propositions, especially financial propositions. (N.C.)

  13. Eradication of White Grub (Melolontha Vulgaris F.) by the Sterile - Male Technique; Eradication du ver blanc (Melolontha Vulgaris F.) par la methode du lacher de males steriles; Unichtozhenie lichinok majskogo zhuka (Melolontha Vulgaris F.) metodom sterilizatsii muzhskikh osobej; Erradicacion de la larva del abejorro (Melolontha Vulgaris F.) por la tecnica de los machos esterilizados

    Energy Technology Data Exchange (ETDEWEB)

    Horber, E. [Swiss Experimental Station for Agriculture, Zurich-Oerlikon (Switzerland)

    1963-09-15

    breeding of which in large masses is not feasible because of the long breeding cycle. (author) [French] Des essais en laboratoire ont montre qu'une dose de rayons X de 3000 r suffit pour steriliser les hannetons males. Des males sterilises ont ete laches, au cours de deux apparitions, dans une population naturelle en vue d'eliminer les vers blancs dans une region essentiellement agricole du nord-ouest de la Suisse. En 1950, une invasion de hannetons avait pu etre enrayee i l'aide d'un traitement chimique. L'evolution ulterieure a ete observee a chaque apparition, de 1953 a 1962. En 1959, on a choisi cinq zones d'environ 30 hectares chacune, reparties en trois categories: a) Zone traitee, oue les males etaient captures, irradies et relaches; b) Zone de reserve, ou les hannetons etaient ramasses, les males irradies et relaches en a; c) Zones temoins, ou l'on observait l'evolution naturelle. L'irradiation des males etait effectuee dans un appareil de roentgentherapie. Les males irradies recevaient des marques peintes a la main, afin de pouvoir evaluer la proportion de males steriles par la methode de dilution isotopique. En 1959, annee du premier traitement, on a relache en a) environ 6 l de males sterilises, ce qui representait pres de 50% de la population male. D'apres les echantillons preleves dam les pres, le nombre de ven blancs n'etait plus par la suite que les deux tiers de leur nombre dans les autres zones. Le taux de reproduction n'etait Inferieur a l'unite que dans la zone a). En evaluant le nombre des hannetons survivants en 1962, on a constate que la population de a) etait tombee a un dixieme de celle de b) et c). C'est en a) que la mortalite a ete la plus elevee entre 1959 et 1962. En 1962, annee du deuxieme traitement, on a relache en a) 17 l de males irradies. La population male de a) avait ete sterilisee dans la proportion d'au moins 76%. Les echantillons preleves par la suite ont montre que l'eradication des vers blancs en a) etait absolue. On a egalement

  14. Pourquoi le « Disque Blanc » des Beatles est-il Blanc ?

    Directory of Open Access Journals (Sweden)

    Bernard Gensane

    2006-02-01

    Full Text Available Dans « Strawberry Fields Forever » (février 1967, John Lennon prévient, dans une perspective postmoderne, que la représentation artistique est impossible car « nothing is real ». Au même moment, Paul McCartney propose, avec « Penny Lane » (février 1967, une des plus troublantes définitions de ce qu’est la représentation artistique : « And though she feels as if she’s in a play / She is anyway ». Que se passe-t-il, en effet, lorsque l’art est sciemment accepté comme un faux-semblant à la foi...

  15. Background and Measurability of Test Samples in an Emergency Situation; Bruit de Fond et Possibilite de Mesurer des Echantillons en Cas d'Accident Radiologique; 0424 041e 041d 0418 0418 0417 041c 0414 ; Radiactividad de Fondo y Posibilidad de Medir Muestras en Casos de Urgencia

    Energy Technology Data Exchange (ETDEWEB)

    Widell, C. -O. [AB Atomenergi, Nykoeping (Sweden)

    1965-06-15

    Background radiation levels in the vicinity of a reactor, after a ''maximum credible accident'', have been calculated. Based on this the measurability of test samples from air and of human bodies is studied. It was found possible to analyse radiometrically air-filter samples from 0.1 m{sup 3} air contaminated to 100 MPC (40 h) {alpha}-activity, 100 MPC (40 h) iodine-131 activity and 10 MPC (40 h) {alpha}-activity in a gamma background of 2 r/h. These measurements were carried out in the normal equipments in the counting-room 400 m away from the actual reactor. It is, however, necessary to use well-shielded counters (e.g. 10-cm lead shield). It was also found satisfactory to make rapid {beta}-analyses with an end-window G-M tube ordinarily used in routine control in a 10-cm lead shield. The analyses of iodine-131 had to be carried out in a gamma spectrometer but measuring times of 100 s were found to be satisfactory. Also the spectrometers need to be shielded with at least 10 cm of lead. It might be difficult to investigate body burdens of the order of one permissible quarterly intake in an ordinary human body counter if the gamma background is increased to very high levels. In such instances it would be useful either to be able to move the human body counter off the site or to have a transportable counter available. The influence of a raised background is illustrated with figures for an iron-room with 16-cm walls and a 4 in X 8 in Nal crystal. All the figures above are calculated with large errors due to large fluctuations in the gamma fields. It is necessary to count the background before as well as after the counting of the sample if no monitor is available. (author) [French] L'auteur a calcule le bruit de fond au voisinage d*un reacteur apres un 'accident maximum previsible'. Sur la base de ces calculs, il etudie la possibilite de mesurer la radioactivite d'echantillons d'air et de tissus humains. Il a ete possible de proceder a l'analyse radiometrique d

  16. Tėvo ir dukters ryšio restauravimo galimybė Hélène Cixous kūriniuose Viduje ir Taigi, mano tėvo laiškai | La possibilité de restaurer le rapport entre le père et la fille dans les oeuvres d’Hélène Cixous Dedans et Or, les lettres de mon père

    Directory of Open Access Journals (Sweden)

    Neringa Mikalauskienė

    2012-01-01

    Full Text Available Dans cet article, on débat une possibilité de restau­rer le rapport entre le père et la fille dans les oeuvres d’Hélène Cixous Dedans (1967 et Or, les lettres de mon père (1997.L’analyse des textes de Cixous est fondée sur la méthode psychanalytique de la critique littéraire à partir des thèses principales de Freud et de Lacan. Nous supposons que c’est le langage (oral ainsi qu’écrit qui montre le rapport entre le père et sa fille dans les oeuvres de Cixous.L’image du père dans les oeuvres d’Hélène Cixous est reconstruite d’après les souvenirs de l’enfance. Dans le roman Dedans on trouve le père idéal avec qui la narratrice fait son identité à l’aide du langage. Mais la langue se transforme toujours, ce qui menace de réfuter la stabilité de son monde. On suppose que le meilleur mode de reconstituer l’ordre précédent, c’est d’écrire un récit sur le père en tant qu’une figure figée. Ainsi on constitue, sur le plan de l’art, un nouveau rapport avec le père à travers le statut d’une oeuvre d’art. L’image du père omnipo­tent est transformée en père-personnage qui devient subordonné à la volonté de l’auteur de conserver tout ce qu’elle avait établi dans son imaginaire et de le présenter au lecteur comme elle le veut.Donc l’analyse des oeuvres montre que la pos­sibilité de restaurer le rapport entre le père et la fille n’existe pas au sens propre. Mais nous considérons que les textes de cette auteure sont intéressants en tant que des exemples de la littérature contemporaine qui représente la synthèse des genres.

  17. Effet du Kétoconazole sur le temps d'immobilité et la réponse ...

    African Journals Online (AJOL)

    La depression est installée suite aux perturbations des activités de l'axe corticotrope et du système immunitaire. L'objectif de cette étude est d'explorer les effets du ketoconazole (KTCZ), un dérivé d'imidazole, inhibiteur de stréroїdogénèse surrénalienne, sur les variations du nombre de globules blancs totaux et des ...

  18. LE SYNDROME DE POURFOUR DU PETIT : UNE MANIFESTATION ...

    African Journals Online (AJOL)

    cervicale intéressant toute la loge viscérale, la loge vascu- laire gauche et arrivant jusqu'au médiastin supérieur. (flèche). Le reflexe photomoteur direct et consensuel ainsi que l'oculomotricité étaient normaux. Le syndrome infectieux était marqué à la biologie avec une CRP à 330mmol et des globules blancs à 30 000 ...

  19. Scaling Research Results: Design and Evaluation | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... deux facettes des enzymes de modification de l'ADN endogène : promouvoir les mutations génétiques ainsi que la réparation du génome. Les lymphocytes B, un type de globules blancs du système immunitaire, produisent et exportent des anticorps qui cherchent des microbes et des toxines, s'y fixent et les neutralisent.

  20. Résultats de recherche | Page 35 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... deux facettes des enzymes de modification de l'ADN endogène : promouvoir les mutations génétiques ainsi que la réparation du génome. Les lymphocytes B, un type de globules blancs du système immunitaire, produisent et exportent des anticorps qui cherchent des microbes et des toxines, s'y fixent et les neutralisent.

  1. Ce que nous faisons | Page 14 | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... deux facettes des enzymes de modification de l'ADN endogène : promouvoir les mutations génétiques ainsi que la réparation du génome. Les lymphocytes B, un type de globules blancs du système immunitaire, produisent et exportent des anticorps qui cherchent des microbes et des toxines, s'y fixent et les neutralisent.

  2. Some Possibilities of the Eddy-Current Method for Multi-Parameter Testing of Structural Components; Quelques Possibilites Offertes par la Methode des Courants de Foucault pour le Controle de Nombreux Parametres des Elements de Construction; Nekotorye vozmozhnosti metoda vikhrevykh tokov dlya mnogoparametrovogo kontrolya ehlementov konstruktsij; Algunas Posibilidades que Brinda el Metodo de las Corrientes de Foucault para Controlar Numerosos Parametros de los Elementos de Construccion

    Energy Technology Data Exchange (ETDEWEB)

    Vjahorev, V. G.; Gerasimov, V. G.; Deniskin, V. P.; Trahtenberg, L. I.; Shkarlet, Ju. M. [Gosudarstvennyj Komitet po Ispol' zovaniju Atomnoj Jenergii SSSR, Moskva, SSSR (Russian Federation)

    1965-09-15

    donnees calculees et experimentales, les auteurs indiquent diverses possibilites de realisation de detecteurs a courants de Foucault de frequence unique permettant le controle avec modification simultanee de plusieurs parametres. (author) [Spanish] Los autores demuestran que los problemas del control no destructivo de diversos parametros se plantean en la tecnologia nuclear segun ciertas leyes y que el metodo de las corrientes de Foucault se adapta particularmente a la solucion de varios de esos problemas. Los autores justifican la utilizacion de modelos electricos para resolver problemas de control con ayuda de una larga bobina hueca. Presentan formulas y exponen un metodo para el calculo de detectores a base de corrientes parasitas. Describen un dispositivo que permite verificar el espesor de las paredes de tubos; en este dispositivo, el desplazamiento del tubo a controlar no ejerce influencia alguna sobre los resultados de las mediciones, gracias al empleo de un monitor accionado por una senal dependiente de la fase de tension del detector. En calidad de detector se ha empleado un dispositivo destinado al control de los tubos de un autogenerador despues de haber incluido en su circuito una bobina de ensayo. Partiendo de datos calculados y experimentales, los autores senalan diversas posibilidades de realizacion de detectores a base de corrientes de Foucault de frecuencia unica, que permiten efectuar el control con modificacion simultanea de varios parametros. (author) [Russian] Pokazana zakonomernost' voznikno- venija zadach o nerazrushajushhem mnogoparametrovom kontrole v jadernoj tehnologii i celeso- obraznost' reshenija nekotoryh iz nih metodom vihrevyh tokov. Obosnovano primenenie jelektricheskih modelej dlja reshenija zadach kontrolja s ispol'zovaniem dlinnoj prohodnoj katushki. Privodjatsja raschetnye formuly i izlagaetsja metodika rascheta nakladnyh toko- vihrevyh datchikov. Opisana shema pribora dlja kontrolja tolshhiny stenki trub, v kotorom vlijanie pereme

  3. General architecture of the alpha-helical globule.

    Science.gov (United States)

    Murzin, A G; Finkelstein, A V

    1988-12-05

    A model is presented for the arrangement of alpha-helices in globular proteins. In the model, helices are placed on certain ribs of "quasi-spherical" polyhedra. The polyhedra are chosen so as to allow the close packing of helices around a hydrophobic core and to stress the collective interactions of the individual helices. The model predicts a small set of stable architectures for alpha-helices in globular proteins and describes the geometries of the helix packings. Some of the predicted helix arrangements have already been observed in known protein structures; others are new. An analysis of the three-dimensional structures of all proteins for which co-ordinates are available shows that the model closely approximates the arrangements and packing of helices actually observed. The average deviations of the real helix axes from those in the model polyhedra is +/- 20 degrees in orientation and +/- 2 A in position (1 A = 0.1 nm). We also show that for proteins that are not homologous, but whose helix arrangements are described by the same polyhedron, the root-mean-square difference in the position of the C alpha atoms in the helices is 1.6 to 3.0 A.

  4. « Holding that wisp of iridescence »

    Directory of Open Access Journals (Sweden)

    Marie C. Bouchet

    2006-03-01

    Full Text Available Le blanc relève d’une ambiguïté essentielle que reflètent les deux possibilités de sa traduction en anglais, « white » ou « blank ». En effet, l’anglais se distingue une fois de plus par la double ascendance qui caractérise son lexique. Le mot « white » vient du vieil anglais « hwit » et désigne le blanc en tant que nuance colorée (« the color of fresh snow or common salt », Oxford Dictionary of English Etymology, alors que « blank », dont l’origine française est transparente, indique l’abse...

  5. Possibilité de financement pour l'égalité des sexes et le changement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 mars 2018 ... Le CRDI est heureux d'annoncer une nouvelle occasion de financement qui vise à favoriser des mesures de lutte contre les changements climatiques efficaces et à long terme, afin de réduire les inégalités sociales, de promouvoir une plus grande égalité entre les sexes, et d'autonomiser les femmes et les ...

  6. Stimuler les possibilités d'emploi pour les jeunes en Tanzanie ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 déc. 2015 ... ... Résoudre le problème de l'emloi des jeunes en Afrique. Liens connexes : Youth Employment Promotion a Priority Agenda for Tanzania, The Guardian (en anglais); Report: National Stakeholders Consultative Workshop on Youth Employment (PDF, 1,74 Mo) (en anglais); Vidéo de l'atelier sur YouTube ...

  7. L'optimisation des ressources : risques et possibilités pour la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    jmarcil

    il y a modulation des risques. De nombreux bailleurs de fonds investissent de façon soutenue dans la recherche au service du développement, reconnaissant les risques inévitables que cela comporte. Ils estiment souvent que la meilleure manière d'aborder l'optimisation des ressources consacrées à la recherche est de ...

  8. Advanced Authoring Technologies, Capabilities and Opportunities (Technologies avancees d’authoring, possibilites et opportunites)

    Science.gov (United States)

    2011-02-01

    Standardization initiatives (e.g., Reusable eLearning Object Authoring And Delivery (RELOAD)). CURRENT STATUS OF AUTHORING 5 - 2 RTO-TR-HFM-129...produced from existing content in a matter of hours and made available globally on the web or whatever the global information infrastructure becomes in the...computer, but we seem to be heading toward a future in which domain knowledge will be pulled out of the global information infrastructure – on demand and

  9. Jeunes agripreneurs : Élargir les possibilités pour les jeunes dans le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    activités agro-alimentaires en vue d'assurer la transformation agricole et l'emploi des jeunes en Afrique. Ce projet déterminera, élaborera et mettra à l'essai sur le terrain des modèles d'entreprise créatifs et audacieux pour aider les jeunes ...

  10. L'eau dans les villes : de multiples menaces… et possibilités | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 déc. 2010 ... ... coopératives capables de protéger la qualité de l'eau par la collecte des ... de la gestion de l'eau par le Third World Centre for Water Management, l'Association ... Les phénomènes météorologiques extrêmes et l'évolution.

  11. L'eau dans les villes : de multiples menaces… et possibilités | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 déc. 2010 ... Un programme d'apprentissage partagé, soutenu financièrement par le CRDI, aide des agriculteurs à approvisionner en eau des villages pauvres de la .... Quand ils travaillent ensemble, quand ils parviennent à rapprocher les points de vue et à concilier les intérêts, c'est incroyable ce qu'ils arrivent à faire.

  12. Uva da tavola ipocalorica, possibilità di coltivazione e nuove prospettive di mercato

    Directory of Open Access Journals (Sweden)

    Donato Antonacci

    2017-01-01

    Full Text Available According to the CODEX STAN 255 (2007, table grapes can be harvested when the refractometric index reaches at least 16° Brix. Grapes with a lower refractometric index are accepted provided the sugar/acid ratio (Total Soluble Solids/Tritatable Acidity – TSS/TA is at least equal to 20:1 if the Brix level is comprised between 12.5° and 14° Brix, 18:1 if the Brix level is comprised between 14° and 16° Brix. Some table grapes grown in Mediterranean climate can accumulate TSS higher than 16° Brix, with low levels of acidity, thus leading to a TSS/AT ratio even greater than 30: 1. Grapes that accumulate TSS less than 12.5° Brix and low TA levels, hardly reach the recommended ratio TSS/TA of 20:1, rather stopping at lower values. Based on these considerations in 2012 an experimental trial of four years started on a total of 103 table grape cvs. Phenological phases in relation to the acidic and sugar content were measured in order to assess the TSS/TA ratio and build regression lines with TSS. Almost all cvs. showed a significant linear regression, with R2 values higher than 0.80 and a standard error between 00.18 and 1.74. TSS values of 103 cvs. at TSS/TA ratio of 20:1, predicted by means of linear regression equations, , were subjected to cluster analysis based on Euclidean Distance. We identified nine clusters, of which the first two with the predicted TSS between 10.04° and 11.77° Brix (7 cvs. and 12.08° and 12.62° Brix (7 cvs., respectively. Some of the cvs. showing TSS values below 12.5° Brix at the TSS/TA of 20: 1, were subjected to a test panel of 24 tasters, who were asked to indicate the acceptability of these grapes on hedonic scale of 9 points. Preliminary results showed that for some table grapes with TSS below 12.5° Brix, a SST/AT ratio lower than the recommended 20:1 can be proposed, while preserving an acceptability by the consumer. These results suggest a more modern perspective on grapes nutritional intake, which takes into account the real needs of Western countries where diabetes, hyperglycemia, obesity and cardiovascular diseases are the main dismetabolisms arising from a diet too rich in calories. These grapes thus represent a new frontier and an opportunity for producers of table grapes, who want to enterprise a market share on “grape diet”, and represent a genetic basis for breeding aimed at obtaining new hypocaloric grape cultivars.

  13. Risques et possibilités liés aux changements climatiques pour les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... aussi d'évaluer le potentiel que représentent ces marchés innovants pour inciter les ... de un Nuevo Sector en la Economía Sistema B. Institution Country. Chile ... IDRC “unpacks women's empowerment” at McGill University Conference.

  14. Les possibilités pour la réconciliation The possibilities of reconciliation

    Directory of Open Access Journals (Sweden)

    Vlada Urošević

    2012-05-01

    Full Text Available Le roman Comment tuer Apostol ? de l’écrivain macédonien Slobodan Micković (1935-2002, paru en 1994, s’intéresse à l’image du « Jeune Turc ». Habitué à l’image stéréotypée de l’Empire ottoman comme période historique où règnent le despotisme asiatique, l’obscurantisme et la corruption, le lecteur y trouvera une nouvelle situation : à côté des représentants de l’ancienne Turquie, il y a maintenant, aussi, des « Jeunes Turcs » – des gens qui pensent d’une façon différente et qui luttent en faveur d’une Turquie moderne et européanisée. Parmi ces derniers est Ouvaïs-bey, colonel de l’armée turque, héros principal du roman. L’action du roman se déroule en 1908 – dans une période où, sous la pression des nouvelles forces dans la société turque, le sultan est obligé d’accepter des réformes. Mais, parallèlement aux idées progressistes, en Ouvaïs-bey vivent des obsessions du passé : durant son enfance, quelqu’un a tué son père, et, selon ouï-dire, ce serait Apostol, le voïvode d’un groupe de rebelles macédoniens qui se battent contre le pouvoir ottoman. Élevé avec la pensée de la vengeance, Ouvaïs-bey mènera plusieurs fois des actions pour saisir le chef légendaire des « comitadjis ». Il finit par l’attraper. Mais, pendant l’agonie du rebelle blessé, Ouvaïs-bey apprend qu’Apostol est innocent – les meurtriers sont des brigands turcs. Toute la haine qu’il a gardée contre cet homme, tous ses projets pour se venger – tout cela perd sa raison d’être. Il comprend qu’il existait une chance pour une possible réconciliation entre eux – mais que cette chance est manquée. Tout cela était un fatal malentendu. Au même moment, le chef des rebelles sort une bombe cachée. Tous deux meurent dans l’explosion. L’idée de l’auteur est claire : les deux peuples, l’un oppresseur et l’autre oppressé auraient pu vivre ensemble, égaux en droits, dans un pays réformé – mais cette prise de conscience est venue trop tard. La morale qui se dégage de ce roman est : la multiethnicité implique l’oubli des anciennes rancunes.The novel comment tuer apostol (how to kill apostol by the macedonian writer slobodan micković (1935-2002 first appeared in 1994. Anyone familiar with the cliché image of the ottoman empire as dominated by asian despotism, obscurantism and corruption will be surprised: alongside time-worn veterans of the sublime porte, there are the so-called young turks, innovators who fought to modernize and, if you will, europeanize their country. The young turks included ouvaïs-bey, an army colonel, the novel's protagonist. The story is set in 1908 when, under the pressure of new forces within turkish society, the sultan was forced to accept reform. In keeping with the ideas that were infiltrating what we now call turkey, ouvaïs-bey is haunted by his past: he was still a child when his father was murdered. The culprit was supposedly apostol, who belonged to a group of rebel macedonians who resisted the power of the ottomans. Raised with a taste for vengeance, ouvaïs-bey led numerous campaigns to capture the legendary chief of the 'comitadji'. He finally managed to arrest him, in order to find, just as the wounded rebel is dying in agony, that apostol is innocent and that his father's killers were actually turkish bandits. Thus all the hatred toward this man that he harboured, all his dreams of revenge, suddenly lose their meaning. Whether or not there'd been any chance of reconciliation, he lost it once and for all, he now realized. It was all a terrible misunderstanding. And then the rebel chief reveals a bomb and they all die in the explosion. The author's idea is thus clarified: the two peoples — the oppressors and the oppressed — could have peacefully coexisted, with equal rights, in a reformed society. But dawn broke too late. The moral of the story ? Multiethnicity is all about burying hatchets.

  15. Possibilités offertes par les élevages associés

    Directory of Open Access Journals (Sweden)

    Depelchin, J.

    1987-01-01

    Full Text Available Possibilities of inlegrated animal production. This papier gives a possible schedule for setting up a department of statistics or biometry in a new teaching institution in a developing country, in cooperation with some older institution. It is mainly based on twelve years' experience of cooperation between a Belgian and a Moroccan agricultural teaching institution.

  16. Natura di guerra. Possibilità ecocritiche sullo sfondo dei videogiochi strategici

    Directory of Open Access Journals (Sweden)

    Francesco Toniolo

    2016-12-01

    Full Text Available Una possibile lettura ecocritica di tre videogiochi strategici in tempo reale, ambientati in con¬testi differenti (uno storico, uno fantasy e uno fantascientifico, per individuare, sullo sfondo di un genere dominato dall’ideologia dello scontro bellico, un rapporto del videogiocatore e delle civiltà in gioco con l’ambiente.

  17. Femmes et gouvernance locale - exploration de nouvelles possibilités

    International Development Research Centre (IDRC) Digital Library (Canada)

    Journal articles. ICTs and black women's empowerment : unmasking domination in several layers. Download PDF. Journal articles. Exploring new media technologies among young South African Women. Download PDF. Reports. Qualitative report for the Young women Govern South Africa project within the Women-Gov ...

  18. Une possibilité d'ensemencement massif pour induire la fermentation malolactique

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Descout

    1980-03-01

    Nous avons pensé qu'il était possible de provoquer le déclenchement de la dégradation de l'acide malique sur des vins particulièrement résistants en leur incorporant un mélange de bactéries et de levures recueilli par filtration sur diatomées d'un vin qui vient de subir la fermentation malolactique.

  19. Donner aux chercheurs africains la possibilité d'exercer une ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le renforcement de la capacité des chercheurs d'exercer une influence sur les ... Addressing Africa's unmet need for family planning by intensifying sexual and ... conference of McGill's Institute for the Study of International Development.

  20. On the event detected by the Mont Blanc underground neutrino detector on February 23, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Dadykin, V L; Zatsepin, G T; Korchagin, V B

    1988-02-01

    The event detected by the Mont Balnc Soviet -Italian scintillation detector on February 23, 1987 at 2:52:37 are discussed. The corrected energies of the pulases of the event and the probability of the event imitation by the background are presented.

  1. Ecofisiologia da videira (Vitis vinifera L.) sob cultivo protegido, variedades Sauvignon blanc, Cabernet sauvignon e Merlot

    OpenAIRE

    Fernandes, Gabriella Vanderlinde

    2014-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Recursos Genéticos Vegetais, Florianópolis, 2014. O Estado de Santa Catarina tem se destacado no cenário nacional pelo potencial na produção de vinhos finos de qualidade, em função da altitude. No entanto, algumas regiões de Santa Catarina, como o município em estudo, Rancho Queimado, apresentam elevada pluviosidade no período de maturação e colheita, além de riscos d...

  2. White book Escrime. Climatic simulation studies; Livre blanc Escrime. Etude des simulations climatiques

    Energy Technology Data Exchange (ETDEWEB)

    Terray, L [CERFACS, 31 - Toulouse (France); Braconnot, P [Institut Pierre-Simon Laplace IPSL/LSCE, CEA-Orme des Merisiers, 91 - Gif-sur-Yvette (France)

    2007-01-15

    The ESCRIME project aims to manage the analysis realized on the climatic simulations on the framework of the fourth report of the GIEC (group of intergovernmental experts on the climate evolution), in particularly the simulations based on french models. This white book is constituted by 8 chapters: the global scenario, the climatic sensibility, the variation modes, the regionalization and the extremes, the hydrological cycle, the polar regions and the cryo-sphere, the carbon cycle, detection and attributions. (A.L.B.)

  3. White certificate: how to launch the system?; Les certificats blancs: comment lancer le systeme?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    White certificates are a supple and suitable economical system for the quest of diffuse energy saving. It relies on the energy distribution networks and is complementary to other existing system (fiscality, regulation, etc). It is an open system, based on a market logics in order to make energy savings where they are the less costly. This document gathers the synthesis of the conference about white certificates, held in Paris in October 2005, the presentations (transparencies) given by J. Percebois (Creden) about the French system of energy savings and by P. Guyonnet (ATEE) about the way to launch the system of white certificates. The debate with the audience is also reported. (J.S.)

  4. N Reactor Production Assurance Program blance of plant evaluation: report of findings and conclusions

    International Nuclear Information System (INIS)

    Hurd, E.N.; Bitten, E.J.

    1985-03-01

    Fourteen tasks were identified by UNC Nuclear Industries for evaluating the life expectancy of N Reactor structures, systems and components in the Balance of Plant portion of the Production Assurance Program. A Westinghouse Hanford Company (WHC) evaluation team was assigned to each of these fourteen tasks. A uniform set of criteria was used by all teams in evaluating the problems that may be encountered during the extended plant operating lifetime. The overall conclusion is that extended life to those Balance of Plant components and systems studied can be achieved. Problems with the potential for compromising that conclusion are identified, and feasible solutions are provided

  5. Le problème de la criminalité en col blanc

    OpenAIRE

    Sutherland, Edwin H.

    2013-01-01

    Les statistiques pénales indiquent sans équivoque que le taux de criminalité, telle que celle-ci est communément comprise et officiellement mesurée, est élevé dans les classes socio-économiques inférieures et bas dans les classes socio-économiques supérieures. Ainsi conçue, la criminalité inclut les violations ordinaires du code pénal, comme les meurtres, les agressions physiques, les cambriolages, les vols simples et qualifiés, les infractions sexuelles, l’ébriété publique ; mais elle n’incl...

  6. The December 2008 Crammont rock avalanche, Mont Blanc massif area, Italy

    Directory of Open Access Journals (Sweden)

    P. Deline

    2011-12-01

    Full Text Available We describe a 0.5 Mm3 rock avalanche that occurred in 2008 in the western Alps and discuss possible roles of controlling factors in the context of current climate change. The source is located between 2410 m and 2653 m a.s.l. on Mont Crammont and is controlled by a densely fractured rock structure. The main part of the collapsed rock mass deposited at the foot of the rock wall. A smaller part travelled much farther, reaching horizontal and vertical travel distances of 3050 m and 1560 m, respectively. The mobility of the rock mass was enhanced by channelization and snow. The rock-avalanche volume was calculated by comparison of pre- and post-event DTMs, and geomechanical characterization of the detachment zone was extracted from LiDAR point cloud processing. Back analysis of the rock-avalanche runout suggests a two stage event.

    There was no previous rock avalanche activity from the Mont Crammont ridge during the Holocene. The 2008 rock avalanche may have resulted from permafrost degradation in the steep rock wall, as suggested by seepage water in the scar after the collapse in spite of negative air temperatures, and modelling of rock temperatures that indicate warm permafrost (T > −2 °C.

  7. Oenological and Quality Characteristic on Young White Wines (Sauvignon Blanc: Effects of High Hydrostatic Pressure Processing

    Directory of Open Access Journals (Sweden)

    Vilbett Briones-Labarca

    2017-01-01

    Full Text Available High hydrostatic pressure (HHP has shown to have an effect of enhancing some properties without detrimental effects on important quality characteristics, such as colour, pH, and turbidity. This suggests that this technique can be used as an alternative to the existing methods used in wine industry processing. The aim of this study was to investigate the effects of HHP on aroma compounds and also sensory and quality properties of young white wine. HHP treatment did not influence physicochemical parameters, total phenols, and flavonoid contents of white wine; however, the results from analysis of wine indicate that there was a great variation in the concentration of free and total sulphur dioxide (SO2 values and antioxidant capacity of white wine after HHP application. The sensory attributes, such as taste, odour, and overall quality, were not affected by HHP processing at 300 MPa. The chromatic characteristics changed slightly after applying HHP, but these changes could not be visually perceived because they were less than 5%. The use of this technique has the potential to decrease the amount of SO2 added to raw grapes thus maintaining the same properties found in untreated wine. This study provided valuable insights into the biochemical and sensory composition of commercial white wine and how this might change during HHP processing.

  8. El Laberinto de Fortuna, strophes 63-84 : l’œuvre au blanc

    Directory of Open Access Journals (Sweden)

    Francis BEZLER

    2006-01-01

    Full Text Available Le Laberinto de Fortuna de Juan de Mena renvoie au labyrinthe du Grand Œuvre. La preuve de cette thèse est fournie dans le présent article, où l’on essaie de déchiffrer le symbolisme alchimique du Cercle de la Lune (strophes 63-84.El sentido alegórico de El Laberinto de Fortuna de Juan de Mena remite al mundo de la alquimia. La prueba de ello se facilita en este artículo en el que se intenta descifrar el simbolismo alquímico del Círculo de la Luna (estrofas 63-84.

  9. Réponse du fonio blanc (Digitaria exilis Stapf) à l'inoculation avec ...

    African Journals Online (AJOL)

    SARAH

    2016-07-31

    Jul 31, 2016 ... (2004) a montré que l'inoculation avec des .... fasciculatum - Go: G. mosseae - Gm: G. manihotis - Ge : G. etunicatum - Gv : G. verriculosum. Les barres ..... dépendantes de la symbiose mycorhizienne car leurs ..... hybrid cv.

  10. Dosage de l'acide nitro-5 furylacrylique dans les vins blancs (1

    Directory of Open Access Journals (Sweden)

    Suzanne Lafon-Lafourcade

    1975-09-01

    Rappelons que l'acide nitro-5 furylacrylique est une substance jaune, inodore et sans saveur, stable à la lumière et à la chaleur. Ses sels de sodium et de potassium sont très solubles dans l'eau, dans l'alcool et le méthanol, mais insolubles dans les solvants non miscibles à l'eau. Le 5-NFA ne distille pas et n'est pas entraînable par la vapeur d'eau. (1 Travail réalisé en collaboration avec le Conseil Interprofessionnel du Vin de Bordeaux.

  11. Power plants of the future. What possibilities for waste heat ?; Centrales electriques du futur. Quelles possibilites pour les rejets thermiques?

    Energy Technology Data Exchange (ETDEWEB)

    Cherix, G.; Storelli, S. [Centre de Recherches Energetiques et Municipales (CREM), Martigny (Switzerland); Weissbrodt, D. [Swiss Federal Institute of Technology (EPFL), Lausanne (Switzerland); Papina, A. [CTVA SA, Lausanne (Switzerland); Ohana, G. [Services Industriels de Lausanne, Lausanne (Switzerland)

    2008-07-01

    This article discusses how the production of electricity in thermal power stations can be combined with district heating. An analysis of the density of thermal consumption in the french part of Switzerland was done and it shows the region with interest for district heating installations. Different existing installations are commented. The example of district heating in Copenhagen (Denmark) gives practical information and shows that heat can be transported over long distances. A project of district heating for the Lausanne's agglomeration is presented and its influence on reduction of carbon dioxide production is shown. Economical, political and practical aspects are discussed. Figures of heating costs are given.

  12. L'algue rouge Eucheuma spinosum possibilités d'exploitation et de culture aux Antilles

    OpenAIRE

    Barbaroux, Olivier; Perez, René; Dreno, Jean-paul

    1984-01-01

    L'industrie française des algues rouges qui occupe en 1983 le 2e rang mondial, extrait des polysaccharides appelés carraghénanes de certaines espèces d'algues telles que Chondrus crispus, Gigartina stellata, G. skotsbergi, Eucheuma cottonii, E. spinosum, Iridea sp. La principale propriété de ces carraghénanes est de réagir avec les composants du lait pour donner du gel à fine structure, d'ou leur utilisation dans tous les dérivés actuels du lait (pâtisserie, flans, crèmes, glaces, fromages, l...

  13. La deontologia di chi produce e detiene dati statistici: dalla possibilità alla certezza dell'accesso

    Directory of Open Access Journals (Sweden)

    Tito Boeri

    2007-10-01

    Full Text Available The recently approved "Codice di deontologia e buona condotta per il trattamento di dati personali per scopi statistici e scientifici" greatly improves the Italian legislation on the privacy of personal data towards easier access to databases by researchers who intend to use them for non-commercial scientific purposes. However, the new legislation simply allows the researcher to access more and better data, it does not guarantee that the institutions that collect and posses these databases will share them with the scientists. To this end, we propose the introduction of a legal obligation - at least for public institutions - to share with researchers - at least those employed by universities - all statistical data that might be requested for non-commercial scientific studies. In this article, we document our own personal experience of requesting data from public administrations, showing how they are often reluctant, if not openly refuse, to invest resources in the dissemination of basic statistical information for research purposes. Not only would the legal obligation we propose allow these institutions to devote specific resources for the dissemination of statistical data, but it would also protect them from political pressure.

  14. Economic outlook for radiometric selection of ores; Possibilites ouvertes en matiere economique par selection radiometrique des minerais

    Energy Technology Data Exchange (ETDEWEB)

    Formery, P.; Ziegler, V. [Commissariat a l' Energie Atomique, Usine du Bouchet, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The value of an ore can be increased by cutting off it's poor fractions. This selection may be realized at two stages: - part of the ore in situ is unable to cover it's extraction and treatment costs, this defines the 'underground cut-off grade'; - another portion of already extracted ore is unable to cover it's transport and treatment costs; this defines the 'surface cut off grade'. These selections are easily feasible owing to the property of uranium ores of emitting gamma radiations. A diagram makes possible a fast forecast on the effect of this selection upon the weight and metal yields. An attempt is made as well in order to provide the expected effect of the composition of underground cut off and surface cut off. This cut off however, being realized through an appreciation of the radiations, involves an alteration of the weight and metal yields which calls for a correction. A survey of the economic interest of the cut-off is done and an example of valorisation in a given deposit of a section at the limit of operability is proposed. (author) [French] On peut augmenter la valeur d'un minerai en retranchant des fractions pauvres de minerai. Cette selection peut etre realisee a deux stades: - eviter l'abattage d'un minerai incapable de supporter les frais d'extraction et de traitement. On definit ainsi une teneur de 'coupure fond'; - eviter de traiter chimiquement des fractions de minerai deja extraites mais dont la teneur ne justifie pas le transport et le traitement. On definit ainsi une teneur de coupure jour. La propriete des minerais d'uranium d'emettre des rayonnements gamma dont la densite est liee a la teneur permet de realiser tres aisement cette selection. On propose un diagramme permettant de prevoir rapidement l'incidence de cette selection sur les rendements poids et metal. On a tente de prevoir l'effet d'une composition des coupures fond et jour. Toutefois, la coupure etant realisee par une appreciation des rayonnements, il s'introduit une certaine alteration des rendements poids et metal. Une correction s'est donc averee indispensable. Une etude concernant l'interet economique de la coupure a ete faite et un exemple de valorisation possible au sein d'un gisement d'un quartier a la limite d'exploitabilite a ete donne. (auteur)

  15. Déterminer l'incidence de l'industrie extractive sur les possibilités ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Ghana et la Côte d'Ivoire sont des pays voisins possédant des ressources et des environnements socio-culturels similaires, mais dont les stratégies de développement économique sont très différentes. Ce projet permettra de déterminer dans quelle mesure les différences dans les schémas de croissance et la création ...

  16. Possibilités et avantages des plantes médicinales en Amérique latine

    International Development Research Centre (IDRC) Digital Library (Canada)

    1 févr. 2011 ... Le parc national Darién au Panama est le plus grand parc national d'Amérique ... kuna et wounaan — installés dans les limites du parc n'ont pratiquement pas ... Avec l'appui du Centre de recherches pour le développement .... Il importe de se rendre compte que la santé humaine est tributaire de celle ...

  17. Utilization possibilites of waste products from fishing and hunting to biogas and bio-oil production in Uummannaq County

    DEFF Research Database (Denmark)

    Gunnarsdottir, Ragnhildur; Jørgensen, Marianne Willemoes

    2008-01-01

    In spring 2007 a project was carried out at the Arctic Technology Centre in which research of various possibilities of utilizing waste products from fishing and hunting generated in Uummannaq County was performed. Numerous alternatives were identified in the project, which were weighed against...... the specific conditions that apply in Uummannaq County. The best alternatives were evaluated to be biogas production and utilization of fat from the fish waste to produce bio-oil. The results showed that with the price of energy in Greenland in 2009 of 3,71 DKR per kWh, the waste in Uummannaq County would...... amount to approximately 6 million DKR when using biogas production and 5,7 million DKR when using bio-oil. Compared with the energy used in Uummannaq County today, the biogas production would be able to supply 17 percent of the energy and bio-oil production would cover approximately 16 percent....

  18. Étude de la possibilité d'utilisation du rônier comme armature ...

    African Journals Online (AJOL)

    ... traditionnelles, permettent d'envisager son utilisation comme armature dans le béton. ... Les résultats obtenus permettent de confirmer que le rônier peut être utilisé comme ... Keywords : wood, Borassus palm, framework, concrete, beam.

  19. Economic outlook for radiometric selection of ores; Possibilites ouvertes en matiere economique par selection radiometrique des minerais

    Energy Technology Data Exchange (ETDEWEB)

    Formery, P; Ziegler, V [Commissariat a l' Energie Atomique, Usine du Bouchet, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The value of an ore can be increased by cutting off it's poor fractions. This selection may be realized at two stages: - part of the ore in situ is unable to cover it's extraction and treatment costs, this defines the 'underground cut-off grade'; - another portion of already extracted ore is unable to cover it's transport and treatment costs; this defines the 'surface cut off grade'. These selections are easily feasible owing to the property of uranium ores of emitting gamma radiations. A diagram makes possible a fast forecast on the effect of this selection upon the weight and metal yields. An attempt is made as well in order to provide the expected effect of the composition of underground cut off and surface cut off. This cut off however, being realized through an appreciation of the radiations, involves an alteration of the weight and metal yields which calls for a correction. A survey of the economic interest of the cut-off is done and an example of valorisation in a given deposit of a section at the limit of operability is proposed. (author) [French] On peut augmenter la valeur d'un minerai en retranchant des fractions pauvres de minerai. Cette selection peut etre realisee a deux stades: - eviter l'abattage d'un minerai incapable de supporter les frais d'extraction et de traitement. On definit ainsi une teneur de 'coupure fond'; - eviter de traiter chimiquement des fractions de minerai deja extraites mais dont la teneur ne justifie pas le transport et le traitement. On definit ainsi une teneur de coupure jour. La propriete des minerais d'uranium d'emettre des rayonnements gamma dont la densite est liee a la teneur permet de realiser tres aisement cette selection. On propose un diagramme permettant de prevoir rapidement l'incidence de cette selection sur les rendements poids et metal. On a tente de prevoir l'effet d'une composition des coupures fond et jour. Toutefois, la coupure etant realisee par une appreciation des rayonnements, il s'introduit une certaine alteration des rendements poids et metal. Une correction s'est donc averee indispensable. Une etude concernant l'interet economique de la coupure a ete faite et un exemple de valorisation possible au sein d'un gisement d'un quartier a la limite d'exploitabilite a ete donne. (auteur)

  20. Pour lire le résumé complet, Stimuler les possibilités d'emploi pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    en matière de politiques doivent aller au-delà des efforts visant à garder les jeunes à ... qui facilitent le recrutement. Les sociétés du secteur de l' ... la Tanzanie devra se donner une stratégie claire afin d'améliorer ses résultats lamentables sur ...

  1. Accroître les possibilités des jeunes dans les régions rurales en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI lance un nouveau projet dans la région de l'ANASE. L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le développement international (CRDI). Voir davantageLe CRDI lance un nouveau projet dans la région ...

  2. Accroître les possibilités pour les jeunes vulnérables : entendre leur ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le but est de définir des solutions qui prennent en compte les motivations et les aspirations des jeunes NEET, tout en produisant des emplois. Espacio Pu¿blico au Chili sera l'institution coordonnatrice du projet. ... Institution. Espacio Público. Institution Country. Chile. Institution Website. http://www.espaciopublico.cl ...

  3. Adaptation level as the basic health status characteristics: possibilitics of its assessment and forecasting of desadaptation violations

    Directory of Open Access Journals (Sweden)

    Vysochyna I.L.

    2015-09-01

    Full Text Available On the basis of comprehensive survey with integrative assessment of health state (medical history data, physical examination, anthropometry, battery of psychological tests (Eysenck, Shmishek’s Personality Inventory (teen version, tapping - test by E.P. Ilyin, children's questionnaire of neuroses; test for rapid assessment of health, activity and mood, anxiety diagnosis by Spielberg - Khanin; Luscher test, color relations test level of adaptation was defined in 236 children from orphanages aged from 4 to 18 years. The manifestations of maladjustment were registered both on psychological level (neuroticism, high anxiety, decreased performance, activity and psychological endurance, sleep disturbance, presence of accentuation and neurotic disorders and somatic level (recurrent acute respiratory infections, poor physical development, exacerbation of chronic foci of infection and burdened biological history; this summarizes conclusions on a low level of health status of children in orphanages. The author has developed mathematical models of adaptation assessment and prediction of desadaptation, which allowed to identify children at risk for the development of adaptation disorders and children with maladjustment; according to the level and severity of maladaptive disorders correction programs are designed.

  4. Influence of Brownfield Conversion on Evaluating Real Estate and Implemeting the Possibilites of Urban Brownfields in Lithuanian Cities

    Directory of Open Access Journals (Sweden)

    Vytautas Bielinskas

    2015-05-01

    Full Text Available The article deals with the problems of brownfield in Lithuania. The paper overviews Lithuanian and foreign experience of integrating the introduced areas into the urban framework based on social, economic, ecological and cultural contextuality. The main problem, on Lithuanian scale, is the absence of an official definition of urban brownfield. The legal framework in Lithuania does not contain any provisions to be processed. The article is aimed at identifying potential threats to the areas in respect of criteria for urban brownfields, and, according to this review, at revealing possible uses of this land. One of the most effective ways of urban sustainable development is the conversion of former military, industrial and other land accepted as the legacy of the Soviet regime. The authors have established a causal relationship resulting in the emergence of the urban areas of wilderness and developed guidance on using them. The authors have analysed and evaluated the existing real estate developers and current trends towards opportunities for private and public partnership (PPP in Lithuania. Although PPP is widespread in most of European countries, it is a rare phenomenon in Lithuania, and has no deep-rooted tradition of this kind of investment in urban infrastructure; however, evaluation is one of the most potential ways to revitalize abandoned urban territories. Based on practices of foreign countries, the authors have identified PPP as a priority.

  5. Possibilités de franchissement du seuil de Beaucaire par les aloses du Rhône

    Directory of Open Access Journals (Sweden)

    LARINIER M.

    1978-01-01

    Full Text Available Douze barrages ont été construits depuis 1947 sur le Rhône à l'aval de LYON. Aucun des dispositifs de franchissement prévus pour les poissons migrateurs ne donne satisfaction, en particulier en ce qui concerne la remontée des aloses (Alosa alosa et Alosa fallax nilotica. De nombreuses observations réalisées sur le seuil de Beaucaire ont permis de déterminer la vitesse de nage et le comportement des aloses dans l'échelle à ralentisseurs de type LACHADENEDE installée sur cet ouvrage. Aucune alose ne s'engage dans la passe quand la vitesse moyenne y excède 1,5 m/s. L'inefficacité de ce dispositif de franchissement s'explique par son manque d'attractivité et ses caractéristiques hydrauliques inadéquates, compte tenu des faibles capacités de nage des aloses.

  6. Electromagnetic shielding of polypyrrole-sawdust composites: polypyrrole globules and nanotubes

    Czech Academy of Sciences Publication Activity Database

    Babayan, V.; Kazantseva, N. E.; Moučka, R.; Stejskal, Jaroslav

    2017-01-01

    Roč. 24, č. 8 (2017), s. 3445-3451 ISSN 0969-0239 R&D Projects: GA ČR(CZ) GA16-02787S Institutional support: RVO:61389013 Keywords : wood sawdust * conducting polymer * nanotubes Subject RIV: CD - Macromolecular Chemistry OBOR OECD: Polymer science Impact factor: 3.417, year: 2016

  7. The molten-globule residual structure is critical for reflavination of glucose oxidase

    Czech Academy of Sciences Publication Activity Database

    Garajová, K.; Zimmermann, M.; Petrenčáková, M.; Dzurová, L.; Nemergut, M.; Škultéty, L'udovít; Žoldák, G.; Sedlák, E.

    2017-01-01

    Roč. 230, NOV 2017 (2017), s. 74-83 ISSN 0301-4622 Institutional support: RVO:61388971 Keywords : Deflavination * Thermal stability * Hofmeister anions Subject RIV: EE - Microbiology, Virology OBOR OECD: Microbiology Impact factor: 2.402, year: 2016

  8. Papillary haemangioma. A distinctive cutaneous haemangioma of the head and neck area containing eosinophilic hyaline globules

    NARCIS (Netherlands)

    Suurmeijer, A. J. H.; Fletcher, C. D. M.

    2007-01-01

    Aims: To investigate and define a morphologically distinctive group of cutaneous papillary haemangiomas. Methods and results: Eleven patients (seven male, four female, age range 1-77 years, median 57) were identified with a solitary bluish cutaneous papule (median size 11 mm) arising in the head and

  9. Resistance to high level of Cu (Copper) by arbuscular mycorrhizal, saprobe Fungi and Eucalyptus globules

    Energy Technology Data Exchange (ETDEWEB)

    Arriagada, C.; Pereira, G.; Machuca, A.; Alvear, M.; Martin, J.; Ocampo, J.

    2009-07-01

    The effects of saprobe and arbuscular mycorrhizal (AM) fungi on growth, chorophyll, root length colonization and succinate dehydrogenase (SDH) activity was measured in Eucalyptus globulus Labill., plants growing in soil with high level of Cu were investigated. The application of Cu inhibited the development of mycelia of the saprobe fungi Fusarium concolor and Trichoderma koningii and the hyphal length of the arbuscular mycorrhizal fungi (AM) Glomus mosseaae and G. deserticola in vitro. (Author)

  10. Resistance to high level of Cu (Copper) by arbuscular mycorrhizal, saprobe Fungi and Eucalyptus globules

    International Nuclear Information System (INIS)

    Arriagada, C.; Pereira, G.; Machuca, A.; Alvear, M.; Martin, J.; Ocampo, J.

    2009-01-01

    The effects of saprobe and arbuscular mycorrhizal (AM) fungi on growth, chorophyll, root length colonization and succinate dehydrogenase (SDH) activity was measured in Eucalyptus globulus Labill., plants growing in soil with high level of Cu were investigated. The application of Cu inhibited the development of mycelia of the saprobe fungi Fusarium concolor and Trichoderma koningii and the hyphal length of the arbuscular mycorrhizal fungi (AM) Glomus mosseae and G. deserticola in vitro. (Author)

  11. Hierarchically porous graphene in natural graphitic globules from silicate magmatic rocks

    OpenAIRE

    PONOMARCHUK V.A.; TITOV A.T.; MOROZ T.N.; PYRYAEV A.N.; PONOMARCHUK A.V.

    2014-01-01

    Naturally-occurring nanostructured graphites from silicate magmatic rocks, which are rare, were characterized using electron microscope and X-ray spectroscopy. This graphite consists of porous carbon, nanographite layers, microand nanotubes. The porous carbon is classified as macroporous matter with a small amount of mezopores. Evidence for the unusual properties of porous carbon are given: nanographite layers are created at the exposed surface of sample and the nanotubes occurs in the bulk o...

  12. Static and dynamic efficiency of white certificate schemes; L'efficacite statique et dynamique des dispositifs de -certificats blancs-

    Energy Technology Data Exchange (ETDEWEB)

    Giraudet, L.G. [CIRED-ENPC, 94 - Nogent-sur-Marne (France); Finon, D. [CIRED-CNRS, 94 - Nogent-sur-Marne (France)

    2011-07-15

    White Certificate Schemes mandate energy companies to promote energy efficiency through flexibility mechanisms, including the trading of energy savings. They can be characterized as a quantity-based, baseline-and-credit system for the diffusion of energy efficient technologies. This paper compares experiences with White Certificate Schemes in Great Britain, Italy and France, in order to identify the basic drivers of each, and ultimately offer an original interpretation as an adaptive instrument, in the sense that it can take different forms in response to specific institutional contexts. A first analysis shows that Schemes perform well in terms of static efficiency, i.e. they are cost-effective and generate net social benefits over the period considered, though with large discrepancies rooted in different technological potentials. Regarding dynamic efficiency, i.e. the ability to induce and sustain technological change over the long haul, market transformation occurred in Great Britain, but was poorly incentivized in Italy and France by inadequate compliance cost recovery rules. Substantial organizational change has occurred in every country, mainly by strengthening vertical relationships between obliged parties and upstream businesses. Overall, the obligation (rather than the market component) drives the early phases of the Schemes. (authors)

  13. The contributions of the white book on the energies; Les contributions au livre blanc sur les energies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This document provides the contributions to the white book on the energies of the following associations: the Academy of Technology, the ADECA (association for the development of agricultural fuels), the ADEME (agency of the environment and the energy mastership), the AEPN (association of ecologists for the nuclear), the AFG (french association of the gas) and Uprigaz (professional union of the private industries of the gas) and CFPB (french committee of the butane and the propane), the AMORCE (association of local and professional collectivities responsible of the cogeneration, the local energy management and the municipal wastes management), the APSA (association for the protection of the Abers sites), the ATEE (technical association energy environment), Jean Besson, the CEA (atomic energy center), the CFE-CGC (french confederation of the frame CGC), the CFTC (french confederation of the christian), CLER (joining committee on the renewable energies), CNISF (national council of french engineers and scientists), CNPA (national council of the automotive industry, branch of fuels retailers), Concorde energy, B. Dessus and B. Laponche, right to the energy-SOS Futur, EAF (french autonomous electric power), EDF, FEE (France wind energy), FFPI (french federation of independent oil fielders) and UFIP (french union of petroleum industries) and UIP (union of oil importers), FG3E (french federation of administrator enterprises in equipment services, the energy and the environment), FILMM (national syndicate of isolating mineral wools manufacturers) and SNPA (national syndicate of cell plastics), Gaz de Bordeaux, Gaz De France, GPAE (Group of autonomous producers of hydro-energy), HESPUL, IFP (french institute of petroleum), H. Nifenecker, PS (socialist party), RARE (regional agencies of the energy and the environment), Rhonalenergie-environment, RTE (electric power transport network), SER (syndicat of the renewable energies), SFEN (french society of the nuclear energy), Total, UFE (french union of the electric power), Electralabel France, GPAE (group of autonomous producers of hydro energy), CNR (national company of the Rhone), SHEM (hydroelectric power society of the south), UMP (union for a popular movement), UNIDEN (union of enterprises using the energy), the greens, WWF (world wildlife foundation). (A.L.B.)

  14. Environmental factors controlling the seasonal variability in particle sizedistribution of modern Saharan dust deposited off Cape Blanc

    NARCIS (Netherlands)

    Friese, C.A.; van der Does, M.; Merkel, U.; Iversen, M.H.; Fischer, G.; Stuut, J-B W.

    2016-01-01

    The particle sizes of Saharan dust in marine sediment core records have been used frequently as a proxyfor trade-wind speed. However, there are still large uncertainties with respect to the seasonality of theparticle sizes of deposited Saharan dust off northwestern Africa and the factors influencing

  15. Counsel meetings about the White book on energies; Reunion de concertation sur le livre blanc sur les energies

    Energy Technology Data Exchange (ETDEWEB)

    Maillard, D

    2003-12-01

    These reunions aim to discuss the opinion of experts on the energy about the law project on the energies, integrated in the White Book. The first reunion concerns the control of the energy demand, the second reunion is devoted to the territory and social solidarities, the renewable energies development and the situation of Corsica and the overseas territories. The third reunion deals with the supply security. (A.L.B.)

  16. Results of low energy background measurements with the Liquid Scintillation Detector (LSD) of the Mont Blanc Laboratory

    Science.gov (United States)

    Aglietta, M.; Badino, G.; Bologna, G. F.; Castagnoli, C.; Fulgione, W.; Galeotti, P.; Saavedra, O.; Trinchero, G. C.; Vernetto, S.; Dadykin, V. L.

    1985-01-01

    The 90 tons liquid scintillation detector (LSD) is fully running since October 1984, at a depth of 5,200 hg/sq cm of standard rock underground. The main goal is to search for neutrino bursts from collapsing stars. The experiment is very sensitive to detect low energy particles and has a very good signature to gamma-rays from (n,p) reaction which follows the upsilon e + p yields n + e sup + neutrino capture. The analysis of data is presented and the preliminary results on low energy measurements are discussed.

  17. Results of low energy background measurements with the liquid scintillation detector (LSD) of the Mont Blanc Laboratory

    International Nuclear Information System (INIS)

    Aglietta, M.; Badino, G.; Bologna, G.F.

    1985-01-01

    The 90 tons liquid scintillation detector (LSD) has been fully running since October 1984 at a depth of 5,200 hg/sq cm of standard rock underground. The main goal is to search for neutrino bursts from collapsing stars. The experiment is very sensitive to detect low energy particles and has a very good signature to gamma rays from (n,p) reactions which follows the upsilon e + p yields n + e sup + neutrino capture. The analysis of data is presented and the preliminary results on low energy measurements are discussed. 1 ref

  18. The Utopia of Cross-border Regions. Territorial transformation and Cross-Border Governance on Espace Mont-Blanc

    NARCIS (Netherlands)

    Lissandrello, E.

    2006-01-01

    The theories on globalisation, internationalisation, post-nationalism or trans-nationalism dismiss the concept of 'territoriality' within the paradigm of the beyond the 'nation-state' sovereignty. In this work, a diverse idea is sustained: borders and territoriality are not just lost terms within

  19. Collusion et possibilité d’entrée en aval dans une industrie verticalement intégrée

    OpenAIRE

    Avenel, Eric; Caprice, Stéphane

    2015-01-01

    We analyze the impact of an entry threat at the downstream level on the ability of a pair of vertically integrated incumbents to collude. Entrants depend on the vertically integrated firms on the intermediate market for the purchasing of good. While the entry threat leaves collusion profits unchanged, we show that deviation profits are also unchanged and that profits are lower in the punishment periods. Consequently, an entry threat facilitates collusion, thus benefiting to incumbents.

  20. Etude des possibilités de valorisation agricole des écumes et de la bagasse de canne à sucre de SOSUHO (Gabon

    Directory of Open Access Journals (Sweden)

    Makita-Ngadi, J.

    1993-01-01

    Full Text Available Study on the possibilities of agricultural valorisation of sugarcane scums and bagasse of SOSUHO (Gabon. As a first step towards the general use of organic fertilizers in improving poor agricultural yields of soils in the province of Haut-Ogooue, in Gabon, we studied germination and growth of seven different types of plants (maize, Zea mays L. var. 60 ; rice Oryza sativa Var. 1345 ; cacao-tree, Theobroma cacao Var. Forastero ; gombo, Hibiscus esculantus Clenson Spineless var ; culin, Cucurbita pepo Basma var ; aubergine, Solanum melongena, Asgrow var ; soya-bean, Glycine max tropical var. on two six months old sugar cane residues. These residues, froth and bagasse were used by hemselves or mixed with earth or sand. By comparison with commercial compost, we found that froth and bagasse do not inhibit the germination of the seeds studied. However, we found that the growth of all species studied was better in froth than in bagasse. The results of chemical analysis carried out on these residues can explain partially the good growth observed in froth themselves or mixed with earth.

  1. Essai de productions aquicoles intégrées : possibilités d'utilisation des boues de pisciculture comme amendement organique agricole

    Directory of Open Access Journals (Sweden)

    LESEL R.

    1976-07-01

    Full Text Available Des essais comparatifs ont été faits dans le but de déterminer l'efficacité des boues de pisciculture comme amendement organique. Il apparaît que ces boues constituent un amendement aussi efficace qu'un poids équivalent de fumier de ferme.

  2. Etude des possibilités d'amélioration de la finesse de la fibre de coton (synthèse bibliographique

    Directory of Open Access Journals (Sweden)

    Nacoulima, NL.

    2014-01-01

    Full Text Available Study of possible ways to improve cotton fiber fineness. A review. Description of the subject. Cotton is the most important textile fiber worldwide. Its quality has to be constantly improved to increase its competitive advantage over synthetic fibers and to keep up with the continuous modernization of spinning factories. Even though it is not a property of commercial value, fineness constitutes, along with length, strength, color and maturity, a major trait of fiber quality. The spinning of fine fiber results in reduced losses and the production of strong, uniform, lustrous, and soft-touch yarn. Literature. Genetic improvement combined with improved cultural practices: harvesting, ginning and storage have led to significant improvements in cotton fiber length, maturity and strength. To date, cotton producers have not usually been interested in fineness because earlier studies, contrary to the more recent ones, have identified its correlation with reduced yield. In this review we present the factors that influence cotton fiber fineness and show possible ways to improve it. Conclusion. Any factor interfering with fiber growth and fiber development can influence fiber fineness. However, genetic influence is more important than the impact of the environment on fineness. So considering that the other species of the Genus Gossypium represent an important source of genetic variability, the genetic approach seems to be the most beneficial way to improve the fineness of upland cotton fiber.

  3. La ricerca di un senso di sé: la narrazione nei social network come possibilità di ricostruzione del tessuto sociale

    Directory of Open Access Journals (Sweden)

    Antonio Notarbartolo

    2011-04-01

    Full Text Available Diventa difficile, in questa situazione sfuggire alla logica della precarietà, così come riuscire a stabilire un discorso continuativo con una o più persone, se non ricorrendo a qualche trucco “tecnico” migliorativo. Rimane il grosso vantaggio rappresentato dalla comunicazione diretta, quasi in tempo reale, se le persone sono in quel momento collegate al programma, quindi sono in grado di replicare. Diventa quindi il possibile veicolo e motore di movimenti di opinione, di gruppi spontanei di persone, di emozioni che possono diventare “oceaniche”, come quando, in uno stadio gremito, tutti si muovono all’unisono sotto il segno della ola. Vengono così soddisfatte la partecipazione e la reciprocità nel bisogno di relazione, e viene soddisfatto il bisogno delle persone di narrazione, ovvero il bisogno di raccontare con leggerezza ad un possibile interlocutore, o ad una platea, la propria storia in frammenti, attraverso commenti puntuali, espressioni di intento, canzoni e immagini. La narrazione, oggi, è fenomeno sempre più raro, grazie al crollo del valore aggiunto rappresentato dall’esperienza, e si è trasformata in storytelling.

  4. Créer des possibilités d'emploi pour les jeunes en Afrique de l'Est ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    adéquation des besoins des employeurs du secteur privé avec les compétences offertes par les jeunes, et la facilitation de partenariats pour créer un système collaboratif et connecté qui met l'accent sur les besoins des jeunes.

  5. Energy storage. Possibilities of superconductors for high power discharges; Stockage d'energie. Possibilites des supraconducteurs en vue des decharges de grandes puissances

    Energy Technology Data Exchange (ETDEWEB)

    Sole, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    After briefly examining the various processes for energy storage and fast liberation, the author stresses the new possibilities of superconductors in this field. (author) [French] Apres un bref examen des differents procedes de stockage et de liberation rapide d'energie, l'auteur souligne les perspectives nouvelles qu'apportent les supraconducteurs dans ce domaine. (auteur)

  6. Report on the possibilities of long-term storage of irradiated nuclear fuels; Rapport sur les possibilites d'entreposage a long terme de combustibles nucleaires irradies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This report aims at giving a legislative aspect to the many rules that govern the activities of the back-end of the fuel cycle in France. These activities concern the unloading of spent nuclear fuels, their reprocessing, storage, recycling and definitive disposal. The following points are reviewed and commented: the management of non-immediately reprocessed fuels (historical reasons of the 'all wastes reprocessing' initial choice, evolution of the economic and political context, the future reprocessing or the definitive disposal of spent fuels in excess); the inevitable long-term storage of part of the spent fuels (quantities and required properties of long-term stored fuels, the eventuality of a definitive disposal of spent fuels); the criteria that long-term storage facilities must fulfill (confinement measures, reversibility, surveillance and control during the whole duration of the storage); storage concept to be retained (increase of storage pools capacity, long-term storage in pools of reprocessing plants, centralized storage in pools, surface dry-storage on power plant sites, reversible underground storage, subsurface storage and storage/disposal in galleries, surface dry-storage facilities); the preliminary studies for the creation of long-term storage facilities (public information, management by a public French organization, clarifying of the conditions of international circulation of spent fuels); problems linked with the presence of foreign spent fuels in France (downstream of the reprocessing cycle, foreign plutonium and wastes re-shipment); conclusions and recommendations. (J.S.)

  7. Possibilities and limitations of analogue methods for studying the dynamics of nuclear power stations; Possibilites et limitations du calcul analogique pour les etudes dynamiques de centrales nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Caillet, C; Deat, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    1. Introduction: the present paper is devoted to analog simulation of problems related to nuclear reactors other than the simulation of the kinetic equations which is well known. 2. Thermodynamic problems: various problems relative to temperature evolution in a reactor, in a pipe, in an exchanger, in a turbine, are studied, and simulation techniques used by earlier authors are critically reviewed. 3. Pipe simulators: it is shown that this problem can be solved by the use of specialized simulators which will be described and analysed. 4. Rotating machine simulators: the particular aspect of rotating machine calculations introducing frequent use of diagrams is emphasized. A simulator requiring both digital and analogue methods is described. 5. The study of a nuclear power station: as an example it is proposed to discuss problems a rising in connection with the preceding elements (a, b, c, d) when simulating the behaviour of large nuclear plants. The part played by ordinary computing elements for the simulation of the different servomechanism transfer functions is considered and process of regulation is outlined. 6. Conclusion: the necessity of the use of high quality simulators and computers is underlined and the accuracy of the solutions is discussed. (author)Fren. [French] 1. Cinetique des reacteurs: la simulation des equations cinetiques d'un reacteur nucleaire ne pose desormais plus de probleme. II est donc possible de faire le point des differentes applications de la technique analogique dans ce domaine. 2. Les problemes thermodynamiques: on discute les differents problemes poses par l'evolution des temperatures dans un reacteur, dans une tuyauterie, dans un echangeur, dans une turbine, et on passe en revue les techniques de simulation proposees jusqu'a ce jour. 3s simulateurs de tuyauteries: on montre comment les differents problemes poses ci-dessus peuvent etre resolus, pour une classe tres vaste de reacteurs par l'emploi de simulateurs speciaux que l'on decrit en discutant la validite des approximations choisies. 4. Les simulateurs de machines tournantes: on souligne le caractere particulier que presentent les calculs des machines tournantes en raison de la necessite ou l'on est de passer par l'intermediaire d'abaques. On propose l'utilisation d'une memoire a acces aleatoire permettant un traitement analogique de ces problemes. 5. Etude d'une centrale nucleaire: on etudie, sur un exemple, les problemes poses par l'interconnexion d'elements du type precedent pour la simulation de grands ensembles (centrales nucleaires) et on souligne le role des elements ordinaires de calcul. 6. Conclusion: on souligne la necessite pour toutes ces etudes, de disposer d'un materiel de qualite et on discute la signification des resultats ainsi obtenus. (auteur)

  8. La possibilité d'un encadrement juridique des lanceurs d'alerte par l'Union européenne

    OpenAIRE

    Racho, Tania

    2016-01-01

    Plusieurs raisons peuvent justifier la nécessité d’une réglementation pour protéger les lanceurs d'alerte au niveau de l'Union européenne. Les alertes médiatisées concernent des dysfonctionnements aux dimensions européennes voire internationales comme par exemple avec les affaires révélées par Snowden ou le Luxleaks. La pertinence d'une action de l'Union européenne est évidente et permettrait alors d'accorder une protection minimale identique sur le territoire des 28 États membres. Néanmoins,...

  9. Les possibilités de limitation des émissions de plomb par les véhicules automobiles Possibilities of Limiting Leaded Exhaust from Automotive Vehicles

    Directory of Open Access Journals (Sweden)

    Roth J.

    2006-11-01

    Full Text Available Les additifs plombés permettent de satisfaire les besoins en octane des moteurs automobiles actuels. Dans le cadre de la lutte contre la pollution automobile, il est envisagé de réduire ou de supprimer le plomb présent dans les carburants. La suppression brutale, tout en présentant certains avantages, entraîne de nombreux inconvénients, d'ordre purement technique mais également d'ordre financier. La mise au point d'un dispositif de captation, par les sociétés Texaco et Octel, semble permettre d'envisager de maintenir la présence de plomb dans les carburants, tout en réduisant les émissions à l'échappement. Les travaux effectués à l'UTAC ont permis de tester ces dispositifs sur une endurance de 31 000 km. Les résultats obtenus ont permis de dégager un gain d'efficacité d'environ 60 %, les paramètres, bruit et pollution (CO et HC restant par ailleurs inchangés. Leaded additives enable the octane requirements of existing automotive engines to be satisfied. However, as part of the fight against automotive pollution, plans are being drawn up to reduce or eliminate the lead present in fuels. A sudden elimination, although having some advantages, would create a great many disadvantages of a purely technical as well as financiel nature. Texaco and Octet have developed a trapping device that appears to enable lead to be retained in fuels at the same time as reducing exhaust emissions. This device has undergone a 31,000-kilometer endurance test at UTAC. The results reveal an efficiency gain of 60 %, while the noise and pollution (CO and HC parameters remain the same.

  10. Learning Paths and Learning Styles in Dyslexia: Possibilites and Effectiveness--Case Study of Two Elementary School Students Aged 7 Years Old

    Science.gov (United States)

    Tsampalas, Evangelos; Dimitrios, Sarris; Papadimitropoulou, Panagoula; Vergou, Maria; Zakopoulou, Victoria

    2018-01-01

    The difficulty in reading and writing, spelling mistakes and poor speech are considered as the main elements that characterize students with dyslexia. If one thinks that most of the things in a class are based on writing and reading, then the importance of such a learning difficulty is that it is recognized as soon as possible and with appropriate…

  11. Integration of industrial risk in regional policy management. Possibilities of evaluation; L'integration du risque industriel dans les politiques de gestion territoriales. Possibilites d'evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Hubert, Philippe; Pages, Pierre

    1990-02-01

    Since the responsibility for risk management depends more and more on regional factors, evaluation methods and management regulations are not developed enough. This study start from the fact that an important methods exist for evaluation transport of dangerous materials in cities, risk analysis and emergency plans related to classified installations, management of quality of water, 'chronic' industrial risks at local and regional level, probabilistic estimation for industrial plants. The objective is in fact to show what risk analysis could bring to the municipality, the city or the region. [French] Alors que la responsabilite de la maitrise du risque repose de plus en plus sur les collectivites territoriales, soit dans la mouvance naturelle de la decentralisation, soit par des textes specifiques, les moyens d'evaluation et les regles de gestion sont encore tres peu developpes. Cette etude part du fait qu'un materiel important existe cependant: evaluations sur le transport des matieres dangereuses dans les villes, etudes de danger et plans d'intervention associes a la legislation sur les installations classees, gestion de la qualite de l'eau par les agences de bassin, bilans des risques industriels 'chroniques' a l'echelle locale ou regionale, evaluations probabilistes sur des objets industriels. L'objet est donc de montrer ce que peuvent apporter ces analyses dans l'evaluation du risque accidentel dans la collectivite, la ville ou, a cause des implications des strategies de prevention, le departement ou la region. L'heterogeneite de la qualite et de la quantite des resultats que l'on peut attendre en fonction des divers types de risques et de consequences est d'abord mise en valeur. Malgre leurs incertitudes, des modeles existent qui permettent de calculer les victimes d'accidents industriels 'types'. Pour les installations classees et les transports de matieres dangereuses, le calcul du risque est loin d'etre systematique, mais il est pratique. Un second domaine est le calcul des consequences economiques. Les donnees y sont rares, et les methodes encore assez peu developpees. Le dernier domaine est celui de l'eau, qui se distingue des precedents non pas tant par la nature des consequences, mais par la specificite des institutions qui gerent la question, ou des organismes qui l'etudient. A cette etape, une conclusion partielle est que, suivant les cas, le point de depart de l'evaluation devra varier. Parfois l'analyse doit partir des sources de danger, parfois il est necessaire de partir de l'identification des cibles. En general, un aller et retour entre une analyse des sources et des cibles devra s'etablir. La voie principale d'identification des sources de danger reste toutefois le recours aux declarations administratives, pour les 'installations dangereuses' en particulier. L'evaluation, enfin, ne peut etre systematique sans un effort considerable. Dans les zones industrielles, dans la mesure ou la tendance a la quantification des etudes se poursuit et ou l'imperatif de transparence s'impose, l'evaluation est envisageable. Sinon le recours est toujours possible a la litterature internationale pour exploiter les resultats publies, specialement au Royaume Uni et aux Pays Bas sur des installations industrielles types. En revanche, il n'existe pas de barriere juridique ou administrative qui empeche les collectivites territoriales d'effectuer leur propres evaluations sur le Transport des Matieres Dangereuses, evaluations dont la methodologie est aujourd'hui assez bien definie. Ces deux poles bien identifies ne doivent pas faire oublier la presence d'un 'risque accidentel diffus' associe aux petites industries, aux commerces, aux stockages residentiels ou semi residentiels et aux reseaux. Meme si une evaluation quantifiee n'est pas possible, les elements qui peuvent etre rassembles fournissent souvent les regles d'une gestion encore empirique mais deja mieux fondee. La confrontation des sources (p.ex. produits transportes) et des cibles (p.ex. captages d'eau) permet ainsi des classifications dans le domaine de l'eau qui sont mieux adaptees au probleme des deversements accidentels. En effet ni les classifications de danger des produits, essentiellement fondees sur la protection des travailleurs, ni les normes de qualite des eaux ne sont ici pertinentes. Par le recensement des sources de donnees, des methodes et resultats disponibles, ce travail dessine les grandes lignes d'une methodologie d'evaluation. Il indique aussi quels sont les objectifs realistes d'une telle evaluation et son implication dans la gestion. L'evaluation du risque en termes de victimes humaines parait possible a court terme; les premiers resultats permettent aussi de definir la problematique, a savoir le niveau relativement faible du risque accidentel par rapport aux risques chroniques. Des regles de gestion et des actions de prevention peuvent donc etre tirees, mais la rationalisation des choix et leur reproductibilite demande un investissement supplementaire dans la gestion du risque majeur. Le domaine des impacts economiques reste assez peu explore, tant sur le plan des donnees post accidentelles que sur les theories de la valorisation des dommages ou de la 'theorie du risque' qui permettrait de definir le cout a priori de l'accident. Plus qu'a un manque de ressources, cette situation semble due essentiellement a la coupure entre le domaine de l'economie et celui de la prevention. Enfin la question de la pollution accidentelle de l'eau rencontre un probleme similaire dans la mesure ou les objectifs de qualite de l'eau sont difficiles a valoriser, mais des regles de prevention peuvent toutefois etre etablies a partir des analyses de risque dans des cas precis.

  12. Adaptation possibilities of the nuclear electricity production to the demand; Possibilites d'adaptation de la production d'electricite nucleaires a la demande

    Energy Technology Data Exchange (ETDEWEB)

    Acket, C

    2009-02-15

    Meeting about the CO{sub 2} emissions from electric heating showed that the leak of adaptation from nuclear reactors led the use of thermal power plants (coal, petroleum, gas) to control the demand variations. This argument is analyzed in the document: is it possible to replace those thermal power plants by nuclear reactors? In this framework the author analyzes the network needs, the electricity sources and the demand answer and the specificities of the nuclear. (A.L.B.)

  13. Report on the possibilities of long-term storage of irradiated nuclear fuels; Rapport sur les possibilites d'entreposage a long terme de combustibles nucleaires irradies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This report aims at giving a legislative aspect to the many rules that govern the activities of the back-end of the fuel cycle in France. These activities concern the unloading of spent nuclear fuels, their reprocessing, storage, recycling and definitive disposal. The following points are reviewed and commented: the management of non-immediately reprocessed fuels (historical reasons of the 'all wastes reprocessing' initial choice, evolution of the economic and political context, the future reprocessing or the definitive disposal of spent fuels in excess); the inevitable long-term storage of part of the spent fuels (quantities and required properties of long-term stored fuels, the eventuality of a definitive disposal of spent fuels); the criteria that long-term storage facilities must fulfill (confinement measures, reversibility, surveillance and control during the whole duration of the storage); storage concept to be retained (increase of storage pools capacity, long-term storage in pools of reprocessing plants, centralized storage in pools, surface dry-storage on power plant sites, reversible underground storage, subsurface storage and storage/disposal in galleries, surface dry-storage facilities); the preliminary studies for the creation of long-term storage facilities (public information, management by a public French organization, clarifying of the conditions of international circulation of spent fuels); problems linked with the presence of foreign spent fuels in France (downstream of the reprocessing cycle, foreign plutonium and wastes re-shipment); conclusions and recommendations. (J.S.)

  14. La lévitation Diamagnétique à l'Echelle Micrométrique: Applications et Possibilités

    OpenAIRE

    Pigot , Christian

    2008-01-01

    Levitation is a fascinating way to compensate the action of gravity. Diamagnetism is the only physical phenomenon that allows a stable, static and passive levitation at room temperature. However, this magnetic effet is mostly insignificant at ordinary scales. Among the different means to improve the amplitude of this phenomenon, scale reduction is promishing. The present work contributes to the exploration of the possibilities and the potentialities of levitation in the microsystems. The redu...

  15. The effects of low-molecular-weight emulsifiers in O/W-emulsions on microviscosity of non-solidified oil in fat globules and the mobility of emulsifiers at the globule surfaces

    DEFF Research Database (Denmark)

    Munk, Merete B.; Erichsen, Henriette Rifbjerg; Andersen, Mogens Larsen

    2014-01-01

    caseinate and different combinations of lactic acid ester of monoglyceride (LACTEM), unsaturated monoglycerides (GMU) or saturated monoglyceride (GMS) were studied. The non-solidified oil in emulsions made with LACTEM. +. GMU had a high microviscosity, whereas the emulsion made with GMS had a low...... of the spin probe on the droplet surfaces. Conversely, in presence of LACTEM and GMS, the protein surface loads decreased and high surface mobilities were observed. Based on these results it is argued that the high macroscopic viscosity and lipid agglomeration of emulsions containing GMU is due to a lipid...

  16. 36 Etude de l'effet de l'amodiaquine sur les globules rouges infectés ...

    African Journals Online (AJOL)

    BAGUI

    techniques d'analyse multivariée telles que la classification hiérarchique, la méthode des k-moyennes et l'analyse en ... techniques such as hierarchical classification, k-means method and principal component analysis techniques. The ..... [7] - ERIC W. WEISSTEIN,''K-means Clustering Algorithm'' from Wolfram Mathworld.

  17. Polypyrrole prepared in the presence of methyl orange and ethyl orange: nanotubes versus globules in conductivity enhancement

    Czech Academy of Sciences Publication Activity Database

    Li, Yu; Bober, Patrycja; Trchová, Miroslava; Stejskal, Jaroslav

    2017-01-01

    Roč. 5, č. 17 (2017), s. 4236-4245 ISSN 2050-7526 R&D Projects: GA ČR(CZ) GA16-02787S Institutional support: RVO:61389013 Keywords : polypyrrole * nanotubes * conducting polymer Subject RIV: CD - Macromolecular Chemistry OBOR OECD: Polymer science Impact factor: 5.256, year: 2016

  18. A chemically modified [alpha]-amylase with a molten-globule state has entropically driven enhanced thermal stability

    Energy Technology Data Exchange (ETDEWEB)

    Siddiqui, Khawar Sohail; Poljak, Anne; De Francisci, Davide; Guerriero, Gea; Pilak, Oliver; Burg, Dominic; Raftery, Mark J.; Parkin, Don M.; Trewhella, Jill; Cavicchioli, Ricardo (Sydney); (New South)

    2010-11-15

    The thermostability properties of TAA were investigated by chemically modifying carboxyl groups on the surface of the enzyme with AMEs. The TAA{sub MOD} exhibited a 200% improvement in starch-hydrolyzing productivity at 60 C. By studying the kinetic, thermodynamic and biophysical properties, we found that TAA{sub MOD} had formed a thermostable, MG state, in which the unfolding of the tertiary structure preceded that of the secondary structure by at least 20 C. The X-ray crystal structure of TAA{sub MOD} revealed no new permanent interactions (electrostatic or other) resulting from the modification. By deriving thermodynamic activation parameters of TAA{sub MOD}, we rationalised that thermostabilisation have been caused by a decrease in the entropy of the transition state, rather than being enthalpically driven. Far-UV CD shows that the origin of decreased entropy may have arisen from a higher helical content of TAA{sub MOD}. This study provides new insight into the intriguing properties of an MG state resulting from the chemical modification of TAA.

  19. Filter-aided sample preparation with dimethyl labeling to identify and quantify milk fat globule membrane proteins.

    NARCIS (Netherlands)

    Lu, J.; Boeren, J.A.; Vries, de S.C.; Valenberg, van H.J.F.; Vervoort, J.J.M.; Hettinga, K.A.

    2011-01-01

    Bovine milk is a major nutrient source in many countries and it is produced at an industrial scale. Milk is a complex mixture of proteins, fats, carbohydrates, vitamins and minerals. The composition of the bovine milk samples can vary depending on the genetic makeup of the bovine species as well as

  20. Effects of xanthosine on gene expression of mammary epithelial cells using RNA sequencing of goat milk fat globules

    Science.gov (United States)

    Although intramammary xanthosine (XS) treatment was reported to increase the mammary stem cell population and milk yield in bovine and caprine, underlying molecular mechanisms remain unclear. The goal of this study was to evaluate effects of XS treatment on the mammary transcriptome in early lactati...

  1. Study of problems arising from the use of thermal neutron detectors in a pulsed regime. Application to the development of a digital transferometer adapted to receive signals from these detectors; Etude des problemes poses par l'utilisation des detecteurs de neutrons thermiques fonctionnant en regime impulsionnel. Application a la realisation d'un transferometre numerique adapte aux signaux fournis par ces detecteurs

    Energy Technology Data Exchange (ETDEWEB)

    Le Tilly, Y [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-12-01

    The instantaneous value of the counting rate of the pulses given by a fission detector settled in a reactor follows the neutron flux, but it is shown that the counter adds a white noise to the measured signal. This report deals with some possibilities of on line numerical handling afforded by this kind of signals. One considers first the influence of a by N numerical divider and one shows that, acting like a quantifier, it adds to the signal a white noise with the power N{sup 2}/{sub 12}. One, studies afterwards the principle of a digital filter aimed to Fourier analyse the signal. The realization of this device is described. It can be used in transfer function measurements at frequencies below 125 kHz. Some examples of experiments performed with this apparatus are presented. One discusses finally the design, according to the same principle, of a power spectral density analyser in the frequency range 0,01 - 10 000 Hz for random signal of the same kind. (author) [French] La valeur instantanee de la frequence de recurrence des impulsions issues d'un detecteur a fission place dans un reacteur est proportionnelle au flux neutronique. Apres avoir montre que le detecteur ajoute un bruit blanc au signal mesure, on etudie clans ce rapport certaines possibilites de traitement numerique en temps reel offertes par ce type de signaux. On examine d'abord l'influence d'un diviseur numerique par N, et l'on montre que son action, semblable a une quantification, ajoute au signal un bruit blanc de puissance N{sup 2}/{sub 12}. On, etudie ensuite le principe d'un filtre numerique destine a effectuer l'analyse de Fourier du signal, et l'on decrit la realisation de cet appareil qui peut etre utilise pour mesurer des fonctions de transfert a une frequence quelconque inferieure a 10 kHz. Des exemples de mesures faites avec cet appareil sont presentes. On discute enfin la possibilite de realiser suivant le meme principe un analyseur de densite spectrale dans la bande de frequence 0,01 Hz

  2. Production of a pseudo-random square wave using a shift register with binary feedbacks; Generation d'un creneau pseudo-aleatoire par un registre a decalage a contre-reaction binaire

    Energy Technology Data Exchange (ETDEWEB)

    Stern, T E; Cazemajou, J; Macherez, B; Valat, J; Vignon, A

    1964-07-01

    We summarize here the theoretical basis for the production of square wave having the values '1' or '0', the switching times being 'pseudo-random'. More precisely, the square-wave may or may not change value at regular time intervals of length {delta}, with probability approximately. 5 for each alternative. The wave-form is obtained by means of a shift-register having modulo-2 feedback. If the interval {delta} and the feedback connections are well chosen, it is possible to produce a waveform whose autocorrelation function is very close to a Dirac delta function. The square-wave therefore behaves like a quantized white noise, which has very interesting properties in cross-correlation techniques. (authors) [French] On resume ici les bases theoriques permettant d'obtenir un creneau prenant les valeurs '1' ou '0', les instants de commutation etant pseudo-aleatoires. Plus exactement, le creneau a la possibilite de changer (ou de ne pas changer) d'etat a intervalles de temps reguliers, separes par intervalle elementaire {delta}, chacune des deux possibilites possedant une probabilite d'apparition tres voisine de 0,5. Le creneau est obtenu par un registre a decalage (shift register) a contre-reactions logiques modulo-2. Si l'intervalle {delta} et les contre-reactions sont judicieusement choisis, il est possible d'obtenir pour le creneau une fonction d'autocorrelation triangulaire tres voisine d'une impulsion de Dirac. Par suite le creneau se comporte comme un bruit blanc quantifie possedant de tres interessantes proprietes pour les techniques statistiques d'intercorrelation. (auteurs)

  3. Correlations between muons and low energy pulses at LSD of the Mont Blanc laboratory near the time of SN1987A explosion

    International Nuclear Information System (INIS)

    Dadykin, V.L.; Khalchukov, F.F.; Korchagin, P.V.; Korolkova, E.V.; Kudryavtsev, V.A.; Mal'gin, A.S.; Ryasny, V.G.; Ryazhskaya, O.G.; Yakushev, V.F.; Zatsepin, G.T.; Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Fulgione, W.; Galeotti, P.; Saavedra, O.; Trinchero, G.; Vernetto, S.; Turin Univ.

    1989-01-01

    We have analysed the data of LSD from February 10, 1987, to March 7, 1987, in order to search for autocorrelations between all pulses detected by LSD with energy higher than 5 MeV like those occurred at ∼ 3:00 UT on February 23, 1987, between the pulses detected by 3 neutrino telescopes and 2 gravitational wave antennae. We have found 9 pairs of correlated pulses (muon + low energy pulse) from 5:42 UT to 10:13 UT on February 23, 1987. The time differences of pulses in the pairs are less than 2 s, the first pulse in the pair being either muon or low energy pulse. The frequency of such random poissonian fluctuations is ∼1/(10 years). There are no correlations outside statistics between low energy, low energy pulses and muon, muon pulses detected by LSD during the whole time period

  4. "Le panache blanc" - bílý chochol na klobouku : gaskoňští kadeti a emblémy Cyrana z Bergeraku

    Czech Academy of Sciences Publication Activity Database

    Hrbata, Zdeněk

    2014-01-01

    Roč. 11, č. 21 (2014), s. 109-118 ISSN 1214-7915 Institutional support: RVO:68378068 Keywords : French literature * Dumas, Alexander * Cyrano from Bergerac * Rostand, Edmond Subject RIV: AJ - Letters, Mass-media, Audiovision

  5. Yeast-yeast interactions revealed by aromatic profile analysis of Sauvignon Blanc wine fermented by single or co-culture of non-Saccharomyces and Saccharomyces yeasts.

    Science.gov (United States)

    Sadoudi, Mohand; Tourdot-Maréchal, Raphaëlle; Rousseaux, Sandrine; Steyer, Damien; Gallardo-Chacón, Joan-Josep; Ballester, Jordi; Vichi, Stefania; Guérin-Schneider, Rémi; Caixach, Josep; Alexandre, Hervé

    2012-12-01

    There has been increasing interest in the use of selected non-Saccharomyces yeasts in co-culture with Saccharomyces cerevisiae. The main reason is that the multistarter fermentation process is thought to simulate indigenous fermentation, thus increasing wine aroma complexity while avoiding the risks linked to natural fermentation. However, multistarter fermentation is characterised by complex and largely unknown interactions between yeasts. Consequently the resulting wine quality is rather unpredictable. In order to better understand the interactions that take place between non-Saccharomyces and Saccharomyces yeasts during alcoholic fermentation, we analysed the volatile profiles of several mono-culture and co-cultures. Candida zemplinina, Torulaspora delbrueckii and Metschnikowia pulcherrima were used to conduct fermentations either in mono-culture or in co-culture with S. cerevisiae. Up to 48 volatile compounds belonging to different chemical families were quantified. For the first time, we show that C. zemplinina is a strong producer of terpenes and lactones. We demonstrate by means of multivariate analysis that different interactions exist between the co-cultures studied. We observed a synergistic effect on aromatic compound production when M. pulcherrima was in co-culture with S. cerevisiae. However a negative interaction was observed between C. zemplinina and S. cerevisiae, which resulted in a decrease in terpene and lactone content. These interactions are independent of biomass production. The aromatic profiles of T. delbrueckii and S. cerevisiae in mono-culture and in co-culture are very close, and are biomass-dependent, reflecting a neutral interaction. This study reveals that a whole family of compounds could be altered by such interactions. These results suggest that the entire metabolic pathway is affected by these interactions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Combined effects of soil-applied and foliar-applied nitrogen on the nitrogen composition and distribution in water stressed "Vitis vinifera L." cv Sauvignon blanc grapes

    Directory of Open Access Journals (Sweden)

    Rana Jreij

    2009-12-01

    Significance and impact of study: This work helps to provide insight into the effect of N soil fertilization along with foliar fertilization on waterstressed vines. This may be useful in fertilization programs in the Mediterranean area and may help to choose the type and the rate of the N fertilization in case of severe vine water deficit. Also, we provide information of utmost importance on the distribution of summer foliarapplied N in grape tissues.

  7. Origine des levures assurant l'élaboration d'un vin blanc de Touraine. Identification des espèces

    Directory of Open Access Journals (Sweden)

    Claude Cuinier

    1980-06-01

    The author isolates and identifies yeast varieties from the grape and its products (must, wine as well as from the major contamination areas (vine, winery. It is shown that alcoholic fermentation is for the most part carried out by Sacch. cerevisae and other Saccharomyces s.p., all were isolated at the vineyard and a few within the winery.

  8. NEDO's white paper on renewable energy technologies; Livre blanc de la NEDO sur les technologies des energies renouvelables

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This document proposes a synthesis of a 'white paper' published by the Japanese institution NEDO (New Energy and Industrial Technology Development Organization) on the development of technologies in the field of renewable energies. For the various considered energies, this report gives indications of the world market recent evolutions, of Japanese productions and objectives in terms of productions and costs. The different energies treated in this report are: solar photovoltaic, wind, biomass, solar thermal, waves, seas, hydraulic, geothermal, hot springs, snow and ice, sea currents, electricity production by thermo-electrical effect or by piezoelectric modules, reuse of heat produced by factories, use of the thermal gradient between air and water, intelligent communities and networks

  9. Fiches pratiques: Les comparatifs lavent plus blanc; Signe particulier: Belier; Avis de recherche; Mont de piete (Comparatively Speaking; The Sign of Aries; Missing Persons; Pawnshop).

    Science.gov (United States)

    Bourdet, Jean-Francois; And Others

    1992-01-01

    Four activities for the French language classroom are described. These include helping students discover comparative expressions by using advertisements; using horoscopes for teaching vocabulary; using a missing persons report as a source for intermediate to advanced level discussion, collective writing, and questions; and a video designed to…

  10. Determination of a cleaning and decontamination process using solvents; Determination d'une methode de nettoyage et de decontamination par solvant

    Energy Technology Data Exchange (ETDEWEB)

    Boutot, P; Schipfer, P [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1967-03-15

    This work has been carried out on samples of the white cotton serge material of which most of the working overalls of the Nuclear Research Centre are made. The aims are: - to determine,from the decontamination and cleaning points of view, the efficiency of various solvents (white-spirit, trichloroethylene, perchlorethylene and tri-chloro-trifluoroethane) and the role of additives likely to improve the treatment; - to control the textile from the wear and shrinkage points of view; - to try to develop a basic cleaning and decontamination process as a function of the possibilities of each solvent considered. (authors) [French] Cette experimentation pratiquee sur des echantillons de tissu en serge de coton blanc, tissu dans lequel est confectionnee la majorite des tenues de travail du Centre, a pour but: - de determiner, sous l'angle decontamination et nettoyage, l'efficacite de differents solvants (white-spirit, trichlorethylene, perchlorethylene et trichlorotrifluoroethane) ainsi que le role des adjuvants susceptibles d'ameliorer le traitement; - de controler le textile du point de vue usure et retrecissement; - d'essayer de mettre au point un procede de nettoyage et de decontamination type en fonction des possibilites d'emploi de chacun des solvants consideres. (auteurs)

  11. Protistas "incerta sedis" de ofídios do Brasil: Toddia França, 1912 e Pirhemocyton Chatton & Blanc, 1914: estudo comparativo "Incerta sedis" Portists from Brazilian snakes: Toddia França, 1912 and Pirhemocyton Chatton & Blanc, 1914: comparative study

    Directory of Open Access Journals (Sweden)

    Maria Auxiliadora de Sousa

    1973-01-01

    Full Text Available Dentre 683 serpentes procedentes de diferentes pontos do Brasil, 16 (2,4% apresentaram em seu sangue (em glóbulos vermelhos maturos e imaturos Toddia ou Pirhemocyton. Denominamos provisoriamente Toddia os parasitos encontrados em Bothrops moojeni, B. pradoi, B. jararaca e Chironius flavolineatus e Pirhemocyton os encontrados em B. alternatus; fornecemos a primeira referência nestes hospedeiros. Estes parasitos foram estudados comparativamente com o objetivo de estabelecermos a extensão de suas afinidades. Com Toddia de B. moojeni realizamos técnica citoquímica para caracterização de ácidos nucleicos e encontramos positividade apenas para DNA. As maiores afinidades entre os parasitos estudados residiam nas características dos corpúsculos cromáticos e alterações celulares que determinam; observarmos quase total identidade nas maneiras como os parasitos da mesma espécie de serpente se apresentaram. Constatamos a coexistência de inclusões globóides, cristalóides e formas intermediárias associada aos parasitos de B. pradoi e B. alternatus; em C. flavolineatus encotnramos além dos cristais, raríssimas formas intermediárias entre estes e globóides. Afinidades entre Toddia e Pirhemocyton abrangendo o tipo de inclusão contrariam as descrições originais, tornando pouco válida esta separação genérica. Discutimos também os fundamentos da criação das espécies e a possível natureza virótica destes parasitos.Among 683 snakes from several localities of Brazil, 16 (2,4% presented in their blood (in mature or immature red cells Toddia or Pirhemocyton. We named provisorily Toddia the parasites found in Bothrops moojeni, B. pradoi, B. jararaca and Chironius flavolineatus and Pirhemocyton those found in B. alternatus; we give the first reference in these hosts. These parasites were comparatively studied in view to establish the range of their relationship. With Toddia from B. moojeni we attempted nucleic acids by cytochemical methods and we found only DNA. The most affinities among the parasite that we have studied remained on the characters of the chromatic corpuscles and the cellular changes determined by them; we observed almost total identity among the parasites of same species of snakes. We observed the coexistence of globoides, crystalloids and intermediate forms between them allied to the parasites of B. pradoi and B. alternatus; in C. flavolineatus we found younder cristals, scarce intermediary forms between these and globoids. Affinities between Toddia and Pirhemocyton including the type of inclusion oppose to the original descriptions, turning doubtfull this generic separation. We also discuss the basis of the establishment of the species and the possible viral nature of these parasites.

  12. Les réacteurs à membranes : possibilités d'application dans l'industrie pétrolière et pétrochimique Membrane Reactors: Possibilities of Application in the Petroleum and Petrochemical Industry

    Directory of Open Access Journals (Sweden)

    Guy C.

    2006-11-01

    Full Text Available Cet article fait le point sur l'état de la recherche dans le domaine des réacteurs chimiques avec séparation par membrane intégrée et de leur applications dans le domaine du raffinage et de la pétrochimie. Trois applications potentiellement intéressantes sont identifiées et, pour chacune, les avantages de l'utilisation d'un réacteur à membrane sont discutés. Ce sont : la déshydrogénation du propane en propylène, la déshydrogénation d'un naphtène cyclohexanique et le vaporéformage du gaz naturel. Pour ces réactions, les membranes à base de palladium apparaissent les plus performantes compte tenu de leur tenue en température, de leur sélectivité et de leur perméabilité à l'hydrogène. Quelques éléments relatifs à leur développement sont présentés en conclusion. Recently, the use of membrane in reaction engineering has been more and more advocated. The selective separation of the products from the reaction mixture allows to achieve higher conversion or better selectivity or to operate under less severe conditions or with smaller units. This paper presents an update on the recent advances in the field of chemical membrane reactors and on their applications in refining and petrochemistry. Previous work. Most of the possible applications of membrane reactors in petroleum and petrochemical industry concern gaseous catalytic reactions. For this reason, gas permeation membranes are the primary component of membrane reactors. Gas permeation membranes present different types of physical structure : dense, microporous or asymmetric which is a combination of the two. Separating properties of dense membranes are function of the solubility and diffusivity of each gaseous component in the membrane material. For microporous membranes, they follow four mechanisms : Knudsen diffusion, surface diffusion, capillary condensation or molecular sieving. Although organic polymers are the common constituent of gas permeation membrane, their use is very limited in membrane reactors as they cannot withstand temperatures higher than 150°C. Metal, ceramic or glass membrane are preferred. Published work on membrane reactors is mainly concerned with dehydrogenation reactions and the in-situ separation of hydrogen. Dense palladium membranes or microporous inorganic membranes are used. A typical membrane reactor is presented in Fig. 1. The catalyst constitutes a fixed bed in the inside tube where dehydrogenation of cyclohexane into benzene takes place. Hydrogen produced by the reaction, permeates through the palladium wall. Carrier argon is used on the permeate side to lower the partial pressure of hydrogen and therefore increase the permeation rate. The main factors enhancing the equilibrium shift and therefore the conversion are presented in Table 1. Potential applications in the petroleum and petrochemical industry. Three potentially interesting applications are identified and the advantages of using a membrane reactor are discussed. They are : propane dehydrogenation into propylene, cyclohexanic naphthene dehydrogenation and natural gas steam reforming. For these chemical reactions, palladium based membranes show the best performance in terms of temperature resistance, hydrogen selectivity and permeability. The conversion of the dehydrogenation reaction of propane is increased by a higher temperature or a lower pressure as presented in Table 2. Selective draw-off of hydrogen from the reactor through a permeable wall increases the conversion from 48. 6% to 75. 5% (Table 3 or decreases the reaction temperature from 600 to 500°C (Table 4. Table 5 presents the effect of the selective draw-off of hydrogen on the conversion or the operating temperature for conditions found in industrial propane dehydrogenation processes. For a specified conversion, the use of a membrane reactor results in a lower operating temperature which reduces considerably catalyst coking. It allows also the use of common materials for the reactor walls which otherwise would facilitate secondary unwanted reactions. The membrane area necessary for a typical propylene production of 100 000 t/year is reasonable (from 50 to 312 m² as presented in Table 6 in the case of a dense palladium membrane but much too high in the case of a carbon molecular sieve. The discussion of the application of membrane reactors to the dehydrogenation of cyclohexane shows that the operating pressure in the reactor is critical. It should not be increased in order to build a high driving force across the membrane because it would then displace the reaction equilibrium towards the reactants, lowering therefore the equilibrium conversion. For this reason, palladium membranes are all the more attractive as the permeation driving force is proportional to the difference of the square roots of the partial pressures. Steam reforming of natural gas to produce hydrogen is a catalytic endothermic reaction of which conversion is increased by high temperature (Table 7. The traditional process includes the reformer itself, a second reactor to finish converting carbon monoxide and a pressure swing adsorption hydrogen separator. Fig. 2 presents the process if a membrane reactor is used. The effect of the in-situ membrane separation is quantified in Table 8 : for characteristic operating conditions, conversion increases from 0. 678 to 0. 916. In conclusion, some aspects of the development of membrane reactors are discussed. The necessity to develop resistant asymmetric composite membranes with a palladium deposit less than 1 µm is stressed out.

  13. Les possibilités des turbines de détente dans les industries gazière et pétrolière Application of Expansion Turbines in the Gas and Oil Industry

    Directory of Open Access Journals (Sweden)

    Verneau A.

    2006-11-01

    Full Text Available Utilisées depuis longtemps dans l'industrie cryogénique, les turbines de détente voient leur intérêt augmenter actuellement en tant que turbines de récupération de l'énergie des laminages. Cette énergie peut servir à l'entraînement de compresseurs, pompes ou générateurs électriques. Il existe surtout des turbines dans la gamme de 200 à 20 000 ch. Deux types principaux sont développés : les turbines axiales et les turbines radiales. Les particularités techniques et les domaines d'emploi de chaque type sont discutés. Ue intérêt particulier est porté au domaine des petites puissances (de 100 kW jusqu'à quelques centaines de watts. L'évolution du rendement en fonction de la puissance est étudiée et quelques types spéciaux bien adaptés à cette gamme, tels que les turbines périphériques, sont présentés. Quelques indications sur la récupération de l'énergie des liquides par turbines sont également données. Ensuite, plusieurs exemples d'applications sont exposés tels que : récupération de fractions condensables du gaz naturel (butane, propane, éthane, récupération de gaz perdu, récupération de l'énergie des laminages lors de la distribution et au niveau des stockages souterrains, turbine hydraulique de lavage de gaz, récupération de l'énergie des fumées de cracking catalytique, entraînement de petits générateurs électriques dans la gamme de quelques kilowatts à quelques centaines de watts. Enfin, nous abordons la technologie et les dispositions constructives particulières en nous attachant plus spécialement aux problèmes de régulation, étanchéité, paliers. Des techniques nouvelles telles que l'emploi de paliers à gaz et leurs avantages sont décrites. Les difficultés dues aux basses températures et à la condensation sont examinées. Nous terminons par quelques considérations d'ordre économique destinées à prévoir la rentabilité d'une installation de récupération d'énergie. Already used for a long lime in the cryogenic industry, expansion turbines are becoming increasingly attractive as turbines for recovering fluidic energy. This energy can be used to drive compressors, pumps or power generators. Such turbines exist mainly in the 200 hp ta 20,000 hp range. The author discusses two types in particular - axial flow turbines and radial flow turbines - and discusses the technical singularities and the areas of application of each type. Special emphosis is placed on low power ratings (from one hundred to a few hundred kilowatts. The pattern of evolution of efficiency versus power is considered, and certain special types particularly well.

  14. Possibilities of gas-phase radio-chromatography application to permanent-gas analysis; Possibilites de la radiochromatographie en phase gazeuse applications a l'analyse des gaz permanents

    Energy Technology Data Exchange (ETDEWEB)

    Dupuis, M C; Charrier, G; Alba, C; Massimino, D [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1970-07-01

    The gas-phase radio-chromatography technique has been applied to the rapid analysis of permanent gases (H{sub 2}, O{sub 2}, N{sub 2}, A, Kr, Xe, CO, CH{sub 4}) labelled with radioactive indicators ({sup 3}H, {sup 37}A, {sup 85}Kr, {sup 133}Xe). After calibration, the components of such a mixture can be identified and their concentrations measured in less than two hours, using a sample volume of from 0.1 to 10 cm{sup 3}. The minimum detectable activity is of the order of 10{sup -4} {mu}C for each radioactive isotope. The measurements are reproducible to about 2 to 3 per cent. This work has been mainly concerned with the influence of parameters affecting the response of the radioactivity detector (ionization chamber or gas flow proportional counter). The method has very numerous applications both theoretically, for the study of chromatographic phenomena under ideal conditions (infinitesimal concentrations made possible by the use of radioactive tracers), and practically, for rapid and accurate radiochemical analysis of radioactive gas mixtures. (authors) [French] La technique de radiochromatographie en phase gazeuse est appliquee a l'analyse rapide de gaz permanents (H{sub 2}, O{sub 2}, N{sub 2}, A, Kr, Xe, CO, CH{sub 4}) marques par des indicateurs radioactifs ({sup 3}H, {sup 37}A, {sup 85}Kr, {sup 133}Xe). Apres etalonnage, l'identification et la mesure des concentrations des constituants d'un tel melange requierent moins de deux heures, sur un volume d'echantillon de 0.1 a 10 cm{sup 3}. L'activite minimum detectable est de l'ordre de 10{sup -4} {mu}C pour chaque isotope radioactif. La reproductibilite des mesures est de l'ordre de 2 a 3 pour cent. L'etude porte principalement sur l'influence des parametres affectant la reponse du detecteur de radioactivite (chambre d'ionisation, ou compteur proportionnel a circulation). La methode est extremement fertile en applications tant sur le plan theorique pour l'etude du phenomene chromatographique dans les conditions ideales (concentrations infinitesimales permises par l'emploi des traceurs radioactifs) que sur le plan pratique pour des analyses radiochimiques precises et rapides de melanges de gaz radioactifs. (auteurs)

  15. Possibility of ion-exchange column studies using stabilised montmorillonite-H aggregates; Possibilite d'etude d'echanges d'ions en colonne sur des agregats de Montmorillonite-H stabilises

    Energy Technology Data Exchange (ETDEWEB)

    Platzer, R; Bittel, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    The conditions necessary for obtaining stable aggregates of montmorillonite-H, prepared without addition of organic flocculant, is discussed. These aggregates possess the same general ion-exchange properties as montmorillonite-H suspensions, about which many papers have been written. Their insolubility and their stable physical form enable them to be used in columns in exactly the same way as the usual organic ion exchangers. The examples of cation fixation and separation described in this report emphasize the similarities between the properties of this exchanger and those of organic cation-exchange resins, and open up possibilities for the extrapolation of the many investigations carried out on organic exchangers to mineral exchangers of this type. Amongst the essential differences to be remarked, we have shown that the properties of physical stability and chemical exchange remain the same at temperatures up to 300 deg. C, to a first approximation, under very intense {gamma} irradiation. (author) [French] Les conditions d'obtention d'agregats stables de montmorillonite-H prepares sans addition de floculant organique sont discutees. Ces agregats possedent les proprietes generales d'echangeurs d'ions des suspensions de montmorillonite-H, tres etudiees par de nombreux auteurs. Ils presentent une insolubilite et une forme physique stable permettant une utilisation en colonne identique a celle des echangeurs d'ions organiques usuels. Les exemples de fixation et de separation de cations qui ont ete decrits dans cet expose font ressortir les analogies entre les proprietes de cet echangeur et celles des resines organiques echangeurs de cations et permettent d'esperer une extrapolation aux echangeurs mineraux de ce type des tres nombreux travaux consacres aux echangeurs organiques. Parmi les differences essentielles a noter, nous avons mis en evidence que les proprietes de stabilite physique et d'echanges chimiques des agregats de montmorillonite subsistent a des temperatures allant jusqu'a 300 deg. C, et en premiere approximation, sous des irradiations {gamma} tres intenses. (auteur)

  16. Quantitative measurements of small isotopic samples in gaseous mixtures by utilization of some nuclear properties; Etude des possibilites de mesures de faibles quantites de gaz radioactifs dans un melange en utilisant simultanement plusieurs proprietes nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Maragnon, J; Delperie, C

    1967-12-01

    The question is to define the characteristics of a group of measurements allowing the analysis of traces of radioactive rare gases in gas mixtures of different composition. To distinguish the radioactive isotopes from each other and the activity level reaching 10{sup 6} due to their nuclear properties, the method was chosen to use several nuclear properties: gamma radiation energy, beta particle energy, lifetime of excited states. The choice of a plastic scintillator as beta detector allows to answer satisfactorilly to this demand by measurement of nuclear constants because of the short de/excitation time of this detector. Another advantage is that it can be a reservoir for the sample without any destruction nor modification of the sample. The study has been based on the mixture of Kr-85, the analysis of other rare gases follwos immediately from the adopted principle. [French] Les auteurs ont oriente leur recherche vers une solution permettant de distinguer les isotopes radioactifs les uns des autres et dans des rapports d'activite pouvant atteindre 10{sup 6}, grace a plusieurs de leurs proprietes nucleaires, energie de rayonnement gamma, energie de la particule beta, temps de vie des niveaux excites. Le choix d'un scintillateur plastique comme detecteur beta permet de repondre d'une maniere satisfaisante a la mesure des constantes nucleaires en raison du temps de de/excitation rapide de ce scintillateur. Il offre en outre l'avantage de pouvoir servir de reservoir a l'echantillon sans entrainer aucune destruction ni modification de celui-ci. L'etude a ete basee sur la mixture de Kr-85, l'analyse des autre gaz rares decoulant immediatement du principe adopte. (auteur)

  17. Possibilities of gas-phase radio-chromatography application to permanent-gas analysis; Possibilites de la radiochromatographie en phase gazeuse applications a l'analyse des gaz permanents

    Energy Technology Data Exchange (ETDEWEB)

    Dupuis, M.C.; Charrier, G.; Alba, C.; Massimino, D. [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1970-07-01

    The gas-phase radio-chromatography technique has been applied to the rapid analysis of permanent gases (H{sub 2}, O{sub 2}, N{sub 2}, A, Kr, Xe, CO, CH{sub 4}) labelled with radioactive indicators ({sup 3}H, {sup 37}A, {sup 85}Kr, {sup 133}Xe). After calibration, the components of such a mixture can be identified and their concentrations measured in less than two hours, using a sample volume of from 0.1 to 10 cm{sup 3}. The minimum detectable activity is of the order of 10{sup -4} {mu}C for each radioactive isotope. The measurements are reproducible to about 2 to 3 per cent. This work has been mainly concerned with the influence of parameters affecting the response of the radioactivity detector (ionization chamber or gas flow proportional counter). The method has very numerous applications both theoretically, for the study of chromatographic phenomena under ideal conditions (infinitesimal concentrations made possible by the use of radioactive tracers), and practically, for rapid and accurate radiochemical analysis of radioactive gas mixtures. (authors) [French] La technique de radiochromatographie en phase gazeuse est appliquee a l'analyse rapide de gaz permanents (H{sub 2}, O{sub 2}, N{sub 2}, A, Kr, Xe, CO, CH{sub 4}) marques par des indicateurs radioactifs ({sup 3}H, {sup 37}A, {sup 85}Kr, {sup 133}Xe). Apres etalonnage, l'identification et la mesure des concentrations des constituants d'un tel melange requierent moins de deux heures, sur un volume d'echantillon de 0.1 a 10 cm{sup 3}. L'activite minimum detectable est de l'ordre de 10{sup -4} {mu}C pour chaque isotope radioactif. La reproductibilite des mesures est de l'ordre de 2 a 3 pour cent. L'etude porte principalement sur l'influence des parametres affectant la reponse du detecteur de radioactivite (chambre d'ionisation, ou compteur proportionnel a circulation). La methode est extremement fertile en applications tant sur le plan theorique pour l'etude du phenomene chromatographique dans les conditions ideales (concentrations infinitesimales permises par l'emploi des traceurs radioactifs) que sur le plan pratique pour des analyses radiochimiques precises et rapides de melanges de gaz radioactifs. (auteurs)

  18. Purification of MUC1 from Bovine Milk-Fat Globules and Characterization of a Corresponding Full-Length cDNA Clone

    DEFF Research Database (Denmark)

    Pallesen, Lone Tjener; Andersen, Mikkel Holmen; Nielsen, Rune

    2001-01-01

    acid sequences obtained by peptide mapping. The complete amino acid sequence of MUC1 was determined by cloning and sequencing the corresponding bovine mammary gland cDNA, which was shown to encode a protein of 580 amino acid residues comprising a cleavable signal peptide of 22 residues. The deduced...

  19. Enhanced creaming of milk fat globules in milk emulsions by the application of ultrasound and detection by means of optical methods.

    Science.gov (United States)

    Juliano, P; Kutter, A; Cheng, L J; Swiergon, P; Mawson, R; Augustin, M A

    2011-09-01

    The effects of application of ultrasonic waves to recombined milk emulsions (3.5% fat, 7% total solids) and raw milk on fat destabilization and creaming were examined. Coarse and fine recombined emulsions (D[4,3]=9.3 μm and 2.7 μm, respectively) and raw milk (D[4,3]=4.9 μm) were subjected to ultrasound for 5 min at 35°C and 400 kHz or 1.6 MHz (using a single transducer) or 400 kHz (where the emulsion was sandwiched between two transducers). Creaming, as calculated from Turbiscan measurements, was more evident in the coarse recombined emulsion and raw milk compared to that of the recombined fine emulsion. Micrographs confirmed that there was flocculation and coalescence in creamed layer of emulsion. Coalescence was confirmed by particle size measurement. These results imply that ultrasound has potential to pre-dispose fat particles in milk emulsions to creaming in standing wave systems and in systems with inhomogeneous sound distributions. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

  20. Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions.

    Science.gov (United States)

    Peng, Jie; Dong, Wu-Jun; Li, Ling; Xu, Jia-Ming; Jin, Du-Jia; Xia, Xue-Jun; Liu, Yu-Ling

    2015-12-01

    The effect of different high pressure homogenization energy input parameters on mean diameter droplet size (MDS) and droplets with > 5 μm of lipid injectable emulsions were evaluated. All emulsions were prepared at different water bath temperatures or at different rotation speeds and rotor-stator system times, and using different homogenization pressures and numbers of high-pressure system recirculations. The MDS and polydispersity index (PI) value of the emulsions were determined using the dynamic light scattering (DLS) method, and large-diameter tail assessments were performed using the light-obscuration/single particle optical sensing (LO/SPOS) method. Using 1000 bar homogenization pressure and seven recirculations, the energy input parameters related to the rotor-stator system will not have an effect on the final particle size results. When rotor-stator system energy input parameters are fixed, homogenization pressure and recirculation will affect mean particle size and large diameter droplet. Particle size will decrease with increasing homogenization pressure from 400 bar to 1300 bar when homogenization recirculation is fixed; when the homogenization pressure is fixed at 1000 bar, the particle size of both MDS and percent of fat droplets exceeding 5 μm (PFAT 5 ) will decrease with increasing homogenization recirculations, MDS dropped to 173 nm after five cycles and maintained this level, volume-weighted PFAT 5 will drop to 0.038% after three cycles, so the "plateau" of MDS will come up later than that of PFAT 5 , and the optimal particle size is produced when both of them remained at plateau. Excess homogenization recirculation such as nine times under the 1000 bar may lead to PFAT 5 increase to 0.060% rather than a decrease; therefore, the high-pressure homogenization procedure is the key factor affecting the particle size distribution of emulsions. Varying storage conditions (4-25°C) also influenced particle size, especially the PFAT 5 . Copyright © 2015. Published by Elsevier B.V.

  1. Milk fat globule membrane coating of large lipid droplets in the diet of young mice prevents body fat accumulation in adulthood

    NARCIS (Netherlands)

    Baars, Annemarie; Oosting, Annemarie; Engels, Eefje; Kegler, Diane; Kodde, Andrea; Schipper, Lidewij; Verkade, Henkjan J.; van der Beek, Eline M.

    2016-01-01

    Epidemiological studies have demonstrated protective effects of breast-feeding on childhood obesity. Differences between human milk and infant milk formula (IMF) in dietary lipid structure may contribute to this effect. In our mouse model, feeding a diet containing large lipid droplets coated with

  2. Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen/deuterium exchange measurements

    Czech Academy of Sciences Publication Activity Database

    Man, Petr; Montagner, C.; Vitrac, H.; Kavan, Daniel; Pichard, S.; Gillet, D.; Forest, E.; Forge, V.

    2010-01-01

    Roč. 277, č. 3 (2010), s. 653-662 ISSN 1742-464X Institutional research plan: CEZ:AV0Z50200510 Keywords : diphtheria toxin * hydrogen/deuterium exchanges * mass spectrometry Subject RIV: CE - Biochemistry Impact factor: 3.129, year: 2010

  3. Itineraria Phoenicia. OLA, 127, 2004, 635 p., une centaine d’illustrations en couleur ou noir et blanc, se répartissant en plans, en photos de paysages, de villes et d’objets.

    OpenAIRE

    Nunn, Astrid

    2007-01-01

    L’A. nous offre un nouveau livre magistral sur les routes empruntées par les Phéniciens de l’est et de l’ouest. Aucun itinéraire écrit phénicien n’existe : les sources écrites phéniciennes se limitent à quelques inscriptions monumentales, sceaux et monnaies, à quelques lignes sur des tessons de céramique et à trois fragments de papyrus. S’y ajoutent des sources néo-assyriennes, la Bible et l’archéologie. Car la poterie nous permet bien évidemment de reconstituer une voie marchande ou tout au ...

  4. The English and northern (Sweden and Norway) systems regarding the questions posed by the white book; Les systemes anglais et nordiques (Suede et Norvege) au regard des questions posees dans le livre blanc

    Energy Technology Data Exchange (ETDEWEB)

    Secretariat d' Etat a l' Industrie [ed.] [Secretariat d' Etat a l' Industrie, Ministere de l' Economie, des Finances et de l' Industrie, Paris (France)

    1999-06-15

    This report issued at request of Ministry of Economy, Finances and Industry - State Secretariat for Industry, presents an analysis of the way the European countries have liberalized their markets, which will be used to answer the questions posed by the white book titled 'Towards the future organization of the French electricity sector'. In the United Kingdom the reform, initiated on 1 April 1990, occurred as a genuine revolution, with the blow-up of CEGB, the equivalent of EDF in France. In Swede and Norway the evolution was progressive; the electric industry was actually not nationalized and the local collectivities, often owners of the production means, have remained the prominent actors. Other characteristic of these countries is the abundance of natural energetic resources, especially for United Kingdom and Norway where the objective of the power policy is of turning profitable the existent potential and not as in France, where the problem is to cope with the consequences of the lack of natural resources. This report contains two parts. The first part presents the main characteristics of the liberalized systems. Indeed while in an integrated system the logic is 'top - down', in a liberalized system the logic is 'bottom - up' i.e., the coordination is based on the market in a decentralized way. The instrument of this coordination is a contract by which the risks are shared among the actors (producers, bankers, distributors, customers). The central actor of the liberalized system is the network authority, so-called 'independent' with rather large autonomy, nominated by the Minister in charge with the energy policy. The network authority has essentially two functions: control and surveillance. In United Kingdom this agency has among his duties the promotion of competition, particularly in production sector, considered as still having monopole capabilities. In Swede and Norway this authority contents itself of only issuing annually a report on market progress. In liberalized systems still two more features are worth to mention, the appearance of actors unknown in centralized systems (as the suppliers, for instance) and the high 'volatility' of the electricity prices that presses both manufacturers and customers to protect themselves against the market's risks. The second part of the report is devoted to the questions raised in the White Book, namely, service's quality, economic efficiency, service continuity, etc. In conclusion, the French conception of Public Service has not an exact analogue but most of its objectives are assigned actually to the Network Authority, the main task of which is promotion of economic efficiency. The networks either privatized, as in United Kingdom, or still public, as in Norway or Swede, are closely controlled by the Network Authority. This is done via price structure establishment and by imposing an upper level on the revenue of the network operators. In UK the action of the Network Authority was highly instrumental in growth of productivity in the monopolistic sectors of electric industry, i.e., transport and distribution. Norway and Swede are in retard from this point of view. The main beneficiaries of the market liberalization were the industries while the profit of domestic customers is still incipient. In the northern countries in spite of early access to competition the profit was so far low. In its second part the document APIS of the Council for Industrial Policy poses questions and presents ways of approach in UK and northern countries relating to: - The directive and its range; - Reinforcing the Public Service; - Revamping the Electric System to support growth; Preserving the networks for overall profit; - Defining of Public Establishment EDF within the new organization; - Developing an efficient network. Ways of approach in UK and northern countries regulation are presented.

  5. White and Dark Stranger Kings: Kupang in the Early Colonial Era Etrangers rois – blancs et bruns : Kupang aux débuts de l’époque coloniale

    Directory of Open Access Journals (Sweden)

    Hans Hägerdal

    2013-01-01

    Full Text Available The article explores the common Southeast Asian epistemological theme of a “stranger king” as an ordering principle in a polity, a principle that was also relevant in a colonial context. The case studied here is the Dutch colonial post in Kupang, West Timor, in the VOC period, 1653-1800. The Dutch fort was surrounded by five princedoms, which stood in the relation of subordinate allies to the VOC. Four of the five groups had migrated to Kupang due to pressure from the Portuguese and their clients, which dominated the rest of Timor. Arenas of interaction were developed, whereby the elites of the five princedoms deliberated with the Dutch authorities on a regular basis. Their attachment to the Dutch colonial apparatus was actually never broken until the twentieth century, in spite of several reasons for discontent. The article argues that the peculiar situation on Timor, where the five allies were under siege from the clients of the Portuguese, underpinned a system in which the colonial masters were seen as legitimate “princes”, ultimate referents of authority whose very strange-ness enabled them to hold the system in place.Cet article explore le thème épistémologique, commun en Asie du Sud-Est, de l’« étranger-roi » comme principe d’organisation dans un Etat, un principe également pertinent dans le contexte colonial. Il examine le poste colonial hollandais de Kupang à Timor occidental pendant la période de la VOC (1653-1800. Le fort hollandais était entouré de cinq principautés, subordonnées à la VOC dans leur alliance avec celle-ci. Quatre de ces groupes avaient émigré à Kupang à cause de la pression des Portugais et de leurs alliés, qui contrôlaient le reste de l’île. Des plates-formes d’interaction furent développées, dans lesquelles les élites des cinq principautés discutaient régulièrement avec les autorités hollandaises. Leurs liens avec l’appareil colonial ne furent en fait jamais rompus jusqu’au xxe siècle, malgré diverses raisons de mécontentement. L’article postule que cette situation particulière à Timor, où les cinq principautés étaient assiégées par les alliés des Portugais, renvoyait à un système dans lequel le pouvoir colonial était perçu comme « prince » légitime, une référence ultime de l’autorité, dont le caractère étranger même leur permettait de maintenir le fonctionnement du système.

  6. Micro-Scale Characteristics of Insoluble Organic Matter in Chondrites: A Coordinated TEM, STXM and SIMS Study

    Science.gov (United States)

    Nittler, L. R.; Alexander, C. M. O'd.; Cody, G. D.; de Gregorio, B. T.; Kilcoyne, A. L. D.; Stroud, R. M.; Tiwari, A.

    2009-03-01

    A coordinated study of meteoritic insoluble organic matter reveals that hollow organic globules are chemically similar to other IOM, but abundances and sizes of globules vary between meteorites. IOM is sensitive to electron and X-ray induced beam damage.

  7. Human endometrial milk fat globule-epidermal growth factor 8 (MFGE8) is up regulated by estradiol at the transcriptional level, and its secretion via microvesicles is stimulated by human chorionic gonadotropin (hCG)

    KAUST Repository

    Sarhan, Abbaa; Bocca, Silvina; Yu, Liang; Anderson, Sandra; Jacot, Terry; Burch, Tanya; Nyalwidhe, Julius O; Sullivan, Claretta; Kaur, Mandeep; Bajic, Vladimir B.; Oehninger, Sergio

    2013-01-01

    Conclusions: We demonstrated (i) dual effects of E2 and hCG on the regulation of MFGE8, and (ii) MFGE8 protein secretion in association with microvesicles. MFGE8 has the potential to modulate endometrial function and implantation via exocrine and/ or paracrine-autocrine effects. To the best of our knowledge, this is the first demonstration of microvesicular secretion of any regulatory protein by endometrial epithelial cells, providing initial evidence suggestive of microvesicular participation in cellular trafficking information in the non-pregnant and pregnant endometrium.

  8. Human endometrial milk fat globule-epidermal growth factor 8 (MFGE8) is up regulated by estradiol at the transcriptional level, and its secretion via microvesicles is stimulated by human chorionic gonadotropin (hCG)

    KAUST Repository

    Sarhan, Abbaa

    2013-10-17

    Objective: We have recently showed that MFGE8, a novel epithelial cell protein in the human endometrium, upregulated during the window of implantation. We hypothesized that MFGE8 may act as a key modulator of endometrial remodeling and trophoblast invasion. The aims of this study were (i) to investigate the in vitro regulation of human endometrial epithelial cells MFGE8 transcription, translation, and secretion by sex steroids and hCG; and (ii) to examine the possibility of MFGE8 secretion via microvesicles. Design: Experimental in vitro study using Ishikawa cells. Setting: University center. Interventions: Treatment with estradiol (E2), progesterone (P4), and human chorionic gonatropin (hCG). Main outcome measures: MFGE8 mRNA and protein expression, and identification of secreted microvesicles by mass spectrometry (MS) and immunoblotting. Results: E2, but not P4 or hCG, significantly upregulated MFGE8 mRNA expression. hCG significantly increased MFGE8 secretion. Microvesicels obtained after ultracentrifugation were visualized with atomic force microscopy ranging from ~100 to 200 nm. In addition to the expected 46 kD protein, the microvesicles contained a second form of secreted MFGE8 measuring ~30 kD which was confirmed by MS. Conclusions: We demonstrated (i) dual effects of E2 and hCG on the regulation of MFGE8, and (ii) MFGE8 protein secretion in association with microvesicles. MFGE8 has the potential to modulate endometrial function and implantation via exocrine and/ or paracrine-autocrine effects. To the best of our knowledge, this is the first demonstration of microvesicular secretion of any regulatory protein by endometrial epithelial cells, providing initial evidence suggestive of microvesicular participation in cellular trafficking information in the non-pregnant and pregnant endometrium.

  9. Jeu et fiction dans un jeu de cartes à collectionner : le cas de Magic : l’Assemblée

    Directory of Open Access Journals (Sweden)

    Pierre Cuvelier

    2011-06-01

    Full Text Available Le genre du jeu de cartes à collectionner apparaît en 1993 avec Magic : l’Assemblée de Richard Garfield. Si la plupart des émules de Magic sont des jeux dérivés d’univers de licence comme Pokémon, Magic se fondait sur un univers de fantasy inédit, enrichi par des extensions successives, et dont les cartes restent le principal vecteur. Je me propose ici de réfléchir sur les rapports qui se nouent entre le jeu et la fiction dans Magic, et d’examiner les contraintes, le fonctionnement et les principaux procédés fictionnels propres à ce support singulier. Magic fait partie des jeux à composante fictionnelle forte, dont les règles comportent un caractère mimétique certain, bien que limité. Les différents éléments d’une même carte et les cartes entre elles fonctionnent comme des fragments qui se combinent pour pointer vers une réalité fictive qui, bien que conçue par l’éditeur sur le modèle des univers de licence à forte cohérence (notamment les récentes fictions transmédiatiques, laisse à rêver aux joueurs par les blancs et les ambiguïtés inhérentes à cette articulation entre jeu et fiction. Les tâtonnements de l’éditeur au fil des extensions sont riches d’enseignements sur les possibilités et les limites d’un tel support, où la fiction narrative linéaire doit laisser place, à petite échelle, à une fiction plus structurelle, prenant la forme d’environnements mis en tension plutôt que de narrations linéaires.

  10. Linguistique textuelle et poésie plastique : quelques enjeux épistémologiques et méthodologiques

    Directory of Open Access Journals (Sweden)

    Chol Isabelle

    2012-07-01

    Full Text Available L'article a pour objectif de montrer comment certaines productions poétiques, depuis le Coup de dés de Mallarmé faisant de l'espacement un élément de composition du texte écrit, interrogent la textualité dans son processus de construction et ses limites. Il s'agira alors de réfléchir sur les possibilités d'une linguistique de l'écrit qui permette d'envisager les processus de textualisation dont la mise en scène dans certaines productions est aussi une mise en question, ainsi que les processus de stylisation qu'ils engagent. Le projet d'une réflexion concernant les outils d'analyse et la démarche interprétative susceptibles de rendre compte des productions poétiques spatialisées s'inscrit actuellement dans le cadre d'un programme ANR (ANR LEC, resp. I. Chol en cours. L'article proposé vise donc simplement à poser quelques jalons pour cette réflexion rendue nécessaire par un corpus d'oeuvres qui échappent aux classifications. Un corpus qui va du début du XXe siècle à nos jours permettra ainsi d'affronter un certain nombre d'outils d'analyse et de concepts à la pratique, et d'émettre quelques propositions, notamment par rapport au concept d' "objet-texte", par rapport à la notion de "syntaxe" et à l'énonciation. Il s'agira aussi de montrer que l'écart que manifestent ses productions avec l'organisation sémantico-syntaxique que la norme communicationnelle suppose ne saurait se résoudre dans le constat d'un double appartenance sémiotique (linguistique et plastique. La dimension linguistique doit elle-même être réévaluée, en partie du moins, par l'élargissement ou l'ajout de certains concepts aptes à rendre compte de l'ensemble des processus de textualisation et de stylisation, incluant notamment le blanc typographique. Un dernier point qui sera alors aussi abordé est celui de l'apparition de nouvelles normes supposant une nouvelle éthique du langage.

  11. Possibility of gas flow measurements using ionization produced by radioactive sources. Performance obtained using continuous and pulsed ionization; Etude des possibilites de mesure des debits gazeux par l'ionisation creee au moyen de sources radioactives performances obtenues par ionisation continue et par ionisation pulsee

    Energy Technology Data Exchange (ETDEWEB)

    Toudoire, B. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    Two methods for measuring gas flow have been studied, based on the ionization of the fluid by a radioactive source. In the first one, called the continuous method, use is made of the relationship between the flow and the ionic density at a point situated down-stream from the ionizing source. In the second method, called 'pulsed', the time for a burst of ions to pass between two points in the circuit is measured. An attempt has been made to predict and to justify theoretically the experimental results, and to determine to what extent these methods can provide absolute measurements or measurements requiring a calibration using known gas flows. These methods are characterized by the absence of moving parts or of parts under reduced pressure and can yield results with an accuracy of between a few per cent to a few tenths of a per cent. The information, provided in either analog or digital form, can be adapted for use in servo-mechanisms or automatic systems. Two applications of an industrial type are described; they concern gas-flow measurements in a railway braking circuit, and in tubes of 20 and 30 cm diameter. (author) [French] Deux methodes de mesure de debit gazeux ont ete etudiees, basees sur l'ionisation du fluide par une source radioactive. Dans la premiere, dite continue, on exploite la relation existant entre le debit et la densite ionique en un point situe a l'aval de la source ionisante. Dans la seconde, dite pulsee, on mesure le temps de transit de bouffees d'ions entre deux points de la conduite. On s'est efforce de prevoir et de justifier par la theorie les resultats experimentaux, et de preciser dans quelle mesure ces methodes peuvent fournir des mesures absolues ou necessitent un etalonnage a partir de debits connus. Caracterisees par l'absence d'organe mobile ou deprimogene, ces methodes sont susceptibles d'une precision de quelques pour-cent a quelques pour-mille. L'information, fournie sous forme analogique ou numerique, se prete a la realisation de systemes d'asservissement ou d'automatisation. Deux applications a caractere industriel sont decrites, concernant la mesure du debit d'air dans un circuit de freinage de chemin de fer et dans des canalisations de 20 et 30 centimetres de diametre. (auteur)

  12. Possibility of applying the gamma-gamma method to the in situ determination of uranium-ore densities; Les possibilites d'application de la methode gamma-gamma a la determination en place de la densite des minerais d'uranium

    Energy Technology Data Exchange (ETDEWEB)

    Czubek, J; Guitton, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    The principles of the gamma-gamma method are reviewed. It is shown in particular that, under certain conditions, the method makes it possible to obtain a representative measurement of the electronic density. Chemical analyses have been carried out on samples obtained from uranium deposits. The results show that an exact correlation exists between the massive and electronic densities. It is possible to consider the possibility of measuring the density of uranium-containing rocks by the gamma-gamma method. (authors) [French] Les principes de la methode gamma-gamma sont rappeles. En particulier, il est montre que, dans certaines conditions, la methode permet une mesure representative de la densite electronique. Des analyses chimiques ont ete effectuees sur des echantillons provenant de gisements uraniferes. Les resultats indiquent qu'il existe une correlation precise entre leur densite massique et leur densite electronique. Il est possible d'envisager la mesure de la densite des roches uraniferes par la methode gamma-gamma.

  13. Some possible uses of radioisotopes in the rubber industry; Certaines possibilites d'emploi des radioisotopes dans l'industrie du caoutchouc; Nekotorye vozmozhnosti ispol'zovaniya radioaktivnykh izotopov v rezinovoj promyshlennosti; Algunas posibilidades de utilizacion de los radioisotopos en la industria del caucho

    Energy Technology Data Exchange (ETDEWEB)

    Shimorda, J; Mozhishek, M; Klimanek, L; Staroba, J [Nauchno-Issledovatel' skij Institut Tekhnologii Reziny i Plastmass (NIITRP), Gorod Gotval' dov, Chekhoslovatskaya Sotsialisticheskaya Respublika (Czech Republic)

    1962-01-15

    A method is described for using beta-emitters (Tl{sup 204} and S{sup 35}) for measuring the wearing qualities of motor-vehicle tyres, checking the homogeneity of tyre rubber, and non-contact thickness-gauging of rubberized fabrics. (author) [French] Le memoire expose une methode permettant d'employer des emetteurs beta ({sup 204}Tl et {sup 35}S) pour la mesure de la resistance des pneumatiques d'automobiles, le controle de l'uniformite du caoutchouc des pneus et la mesure sans contact de l'epaisseur des tissus caoutchoutes. (author) [Spanish] Los autores describen un metodo de utilizacion de emisores {beta} ({sup 204}Tl y {sup 35}S) para la medicion de la resistencia al desgaste de los neumaticos de automovil para la verificacion de la homogeneidad del caucho destinado a la fabricacion de neumaticos y para la medicion a distancia del espesor de las telas cauchutadas. (author) [Russian] Opisana metodika ispol'zovaniya beta-izluchatelej (Tl{sup 204} i S{sup 35}) dlya izmereniya velichiny iznosostojkosti avtomobil'nykh shin, dlya kontrolya gomogennosti shinnykh rezin i dlya beskontaktnogo izmereniya tolshchiny obrezinennykh tkanej. (author)

  14. Possibilities of long duration generation of vapour of iodine 131 in the air for its trapping in French activated carbons; Possibilites de generation de longue duree dans l'air de vapeur d'iode 131 en vue de son piegeage par les charbons actifs francais

    Energy Technology Data Exchange (ETDEWEB)

    Billard, F.; Chevalier, G.; Pradel, J.

    1962-12-17

    As previous studies performed on activated carbon showed that it was necessary to possess a long duration iodine generator to determine the scope of application of some advanced theories concerning the trap mechanism of different forms of radio-iodines, the authors present a generator which uses the high temperature oxidation of sodium iodide by an air stream or an oxygen stream. A version of this apparatus using a 5 Curie source is planned to check the operation of a trap of 100.000 m{sup 3}/h with a purification coefficient of 10{sup 4}, and aimed at being mounted on the venting circuit of a nuclear reactor enclosure [French] Les etudes que nous avons effectuees sur les charbons actifs nous ont montre qu'il etait necessaire de posseder un generateur d'iode de longue duree pour preciser le domaine d'application de certaines theories avancees concernant le mecanisme de piegeage des differentes formes de radioiodes. Un generateur utilisant l'oxydation de l'iodure de sodium a chaud par un courant d'air ou d'oxygene est decrit. Une version de cet appareil utilisant une source de 5 curies est prevue pour verifier le bon fonctionnement d'un piege de 100.000 m{sup 3}/h ayant un coefficient d'epuration de 10{sup 4} est destine a etre place sur le circuit de ventilation de l'enceinte d'un reacteur nucleaire. (auteurs)

  15. Possibility of observing high energy neutrinos from gamma bursts, with the Antanares telescope, feasibility study; Possibilite d'observation, par le telescope antares, de neutrinos de haute energie associes aux sursauts gamma et validation des techniques de detection a l'aide d'un prototype

    Energy Technology Data Exchange (ETDEWEB)

    Kouchner, A

    2001-04-01

    The European Antares collaboration intends to build a deep-sea neutrino telescope with a detection surface of about 1/10 km{sup 2} in the Mediterranean sea. The universe is transparent to neutrinos, so their study provides a unique means of improving our knowledge of the nature and origin of cosmic rays and their emission from the most powerful astrophysical sources in the cosmos. Neutrinos also offer the possibility of opening a new energy window (E>TeV) for observation of the universe. The first part of the thesis is dedicated to a study of the possibility of using the future telescope to look for correlations between gamma-ray bursts and high-energy neutrinos. It is based, on one hand, on the predictions of neutrino fluxes from gamma-ray bursts in the framework of the theoretical model of 'fireballs', and, on the other hand, on the temporal properties of the gamma-ray bursts in the 4. BATSE catalogue. The second part of the thesis presents the results obtained with a prototype detector line deployed, at the end of 1999, some forty km south-west off Marseilles. The objective was to operate a complete apparatus, similar to the future detector lines, from the shore, and under realistic conditions. Data from 7 photomultiplier tubes disposed along the detector line were transmitted through 37 km of optical fiber to the shore, where they were used to reconstruct tracks due to atmospheric muons, thus validating the detection principles and methods. (author)

  16. Possibility of gas flow measurements using ionization produced by radioactive sources. Performance obtained using continuous and pulsed ionization; Etude des possibilites de mesure des debits gazeux par l'ionisation creee au moyen de sources radioactives performances obtenues par ionisation continue et par ionisation pulsee

    Energy Technology Data Exchange (ETDEWEB)

    Toudoire, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    Two methods for measuring gas flow have been studied, based on the ionization of the fluid by a radioactive source. In the first one, called the continuous method, use is made of the relationship between the flow and the ionic density at a point situated down-stream from the ionizing source. In the second method, called 'pulsed', the time for a burst of ions to pass between two points in the circuit is measured. An attempt has been made to predict and to justify theoretically the experimental results, and to determine to what extent these methods can provide absolute measurements or measurements requiring a calibration using known gas flows. These methods are characterized by the absence of moving parts or of parts under reduced pressure and can yield results with an accuracy of between a few per cent to a few tenths of a per cent. The information, provided in either analog or digital form, can be adapted for use in servo-mechanisms or automatic systems. Two applications of an industrial type are described; they concern gas-flow measurements in a railway braking circuit, and in tubes of 20 and 30 cm diameter. (author) [French] Deux methodes de mesure de debit gazeux ont ete etudiees, basees sur l'ionisation du fluide par une source radioactive. Dans la premiere, dite continue, on exploite la relation existant entre le debit et la densite ionique en un point situe a l'aval de la source ionisante. Dans la seconde, dite pulsee, on mesure le temps de transit de bouffees d'ions entre deux points de la conduite. On s'est efforce de prevoir et de justifier par la theorie les resultats experimentaux, et de preciser dans quelle mesure ces methodes peuvent fournir des mesures absolues ou necessitent un etalonnage a partir de debits connus. Caracterisees par l'absence d'organe mobile ou deprimogene, ces methodes sont susceptibles d'une precision de quelques pour-cent a quelques pour-mille. L'information, fournie sous forme analogique ou numerique, se prete a la realisation de systemes d'asservissement ou d'automatisation. Deux applications a caractere industriel sont decrites, concernant la mesure du debit d'air dans un circuit de freinage de chemin de fer et dans des canalisations de 20 et 30 centimetres de diametre. (auteur)

  17. Possibilités de prise en compte des phénomènes de transferts internes aux grains lors de la modélisation du séchage en lit fixe du maïs : revue

    Directory of Open Access Journals (Sweden)

    Janas, S.

    2012-01-01

    Full Text Available Opportunity to take the grain internal transfers into account in the context of the modelization of the fixed bed drying of corn: a review. The fixed-bed drying is a preservation technique widely used in food industries. Its control and optimization require to know the distributions of temperature and water content in the bed depending on the operating conditions used. This information is obtained through modeling of the heat and mass transfers involved. Models of fixed bed drying have two components. The first one is the model at the product level. This model can predict how temperature and water content of the product change at each point of the bed according to local conditions of temperature and humidity. The second component is the model for the entire bed, which describes how heat and water are conveyed by the drying air through the bed. In this literature review, the main models of fixed bed drying are presented, with particular emphasis on the models used for corn drying. In this review, these two components are presented separately. The goal is to idendify the advantages and disadvantages of each approach, and opportunities for future research in this field.

  18. Possibility of observation by the Antares telescope of the gamma ray point sources observed by the Egret detector and study of a prototype; Possibilite d'observation par le telescope Antares des sources ponctuelles de rayons gamma observees par le detecteur Egret et etude d'un prototype

    Energy Technology Data Exchange (ETDEWEB)

    Saouter, S

    2004-09-01

    The ANTARES collaboration aims to install an underwater neutrino telescope at 2 500 m deep and 40 km away from Toulon (France). The neutrinos are detected thanks to their interaction by charged current in the medium surrounding the telescope which can be rock or water. The produced muon emits Tcherenkov light along its path in water. This light is detected by a three-dimensional network of 900 photomultipliers divided into 12 independent lines. To validate the chosen techniques, a prototype made up of a fifth of line was deployed in 2003. A reconstruction algorithm was developed on simulated data whose results are presented. However, a technical failure made the data recorded by the prototype unsuitable. The detection potential of Antares to gamma ray sources observed by Egret is studied. Indeed, under the assumption of a gamma ray production via high-energy hadrons, a comparable flux of neutrinos associated is predicted. By supposing the two fluxes equal and an energy spectrum varying as E{sup -2} eleven sources are potentially detectable in one year. The Antares sensitivity to such a spectrum depends on the declination of the source with an optimum of 3.6 10{sup -4} m{sup -2} s{sup -1} GeV{sup -1} in one year at 90% of confidence level for a declination of - 90 deg C. (author)

  19. Diffuse Scattering from Alloys and Disordered Systems: Experimental Techniques and Potentialities; Diffusion dans les Alliages et les Systemes Desordonnes; Methodes Experimentales et Possibilites d'Application; Diffuznoe rasseyanie na splavakh i razuporyadochennykh sistemakh. ehksperimental'nye metody i potentsial'nye vozmozhnosti; Dispersion Difusa en Aleaciones y Sistemas Desordenados; Tecnicas Experimentales y Posibilidades

    Energy Technology Data Exchange (ETDEWEB)

    Low, G. G. [Atomic Energy Research Establishment, Harwell, Berks (United Kingdom)

    1965-04-15

    The purpose of this paper is to review, both with regard to principles and practice, the types of information that may be obtained by studying the elastic diffuse scattering of neutrons. Attention will be concentrated on systems where there is a random arrangement of defects each of which may be assumed to be unaffected by the presence of its fellows, either because of dilution or because of an intrinsic lack of dependence on environment. In these circumstances the pattern of scattered intensity is proportional to the square of the modulus of a Fourier transform over the disturbance in scattering amplitude associated with a defect. Thus, information on the spatial distribution of defect scattering amplitude can be obtained by carrying out the relevant neutron scattering measurements and performing a Fourier inversion. In practice, because of the large number of processes contributing to the diffuse scattering background, measurements have so far been possible only in a limited number of fields. In particular considerable progress has been made in connection with magnetic defects in ferromagnets where the magnetic cross-section may be controlled by changing the direction of magnetization relative to the neutron scattering vector. In this way the scattering of interest can be isolated from the non-magnetic effects as a difference between two intensity measurements. A process contributing to the diffuse scattering background which is partly magnetic in character and therefore not eliminated by the above technique is multiple Bragg scattering in a magnetic polycrystal. This may be avoided by the use of a single -crystal specimen or by employing long wavelength neutrons such that no Bragg processes are possible. An instrument based on the latter principle has been developed at Harwell and used in connection with a wide range of measurements on dilute ferromagnetic alloys. These observations are discussed along with a number of other likely future developments in the field. Included among the latter are measurements of the diffuse magnetic scattering from paramagnetic salts. Observations of such scattering are of great interest since they contain direct information on the amount of spin transferred as a result of covalency, from a magnetic ion on to the ligands which surround it. (author) [French] Le memoire a pour objet d'examiner, du point de vue des principes et de la pratique, les divers renseignements que l'on peut obtenir en etudiant la diffusion elastique des neutrons. L'auteur traite surtout des systemes comportant une disposition stochastique des defauts, au sujet desquels on peut supposer qu'aucun n'est affecte par la presence des autres, soit en raison de la dilution, soit en raison d'une independance intrinseque 1 l'egard de l'environnement. Dans ces conditions, l'intensite diffusee est proportionnelle au carre du module d'une transformee de Fourier sur la perturbation de l'amplitude de diffusion associee a un defaut. On peut ainsi obtenir des renseignements sur la distribution spatiale de cette amplitude de diffusion en procedant aux mesures appropriees de diffusion des neutrons et en operant une inversion de Fourier. En pratique, vu le grand nombre de phenomenes qui contribuent au bruit de fond de diffusion, on n'a pu jusqu'a present faire des mesures que pour un petit nombre de champs. On a notamment realise des progres considerables en ce qui concerne les defauts magnetiques dans les ferro-aimants ou l'on peut faire varier la section efficace magnetique en modifiant la direction de magnetisation par rapport au vecteur de diffusion des neutrons. Cto parvient ainsi a separer la diffusion consideree des effets non magnetiques sous la forme d'une difference entre les deux mesures d'intensite. Un phenomene qui contribue au bruit de fond de diffusion et qui possede un caractere partiellement magnetique et par consequent n'est pas elimine par la technique susmentionnee, est la diffusion multiple de Bragg dans un polycristal magnetique. On parvient a l'eviter en utilisant un echantillon monocristal ou en employant des neutrons ayant une longueur d'onde suffisante pour qu'aucun phenomene de Bragg ne puisse se produire. Un appareil fonde sur ce dernier principe a ete mis au point a Harwell et utilise pour une gamme etendue de mesures portant sur des alliages ferromagnetiques dilues. L'auteur discute ces travaux ainsi que plusieurs autres qui pourraient etre entrepris dans ce domaine. Parmi ces derniers figurent des mesures de la diffusion magnetique par les sels paramagnetiques. L'observation de cette diffusion revet un grand interet car elle fournit des renseignements directs sur la fraction de spin transferee, par suite de la covalence, d'un ion magnetique aux coordinats qui l'entourent. (author) [Spanish] La finalidad de la memoria es analizar, desde el punto de vista de la teoria y de la practica, las informaciones que pueden obtenerse estudiando la dispersion elastica difusa de neutrones. Se presta particular atencion a los sistemas con distribucion aleatoria de defectos, cada uno de los cuales puede considerarse aislado de los demas, bien por efecto de la dilucion o bien por ser intrinsecamente independiente del medio. En estas condiciones, la intensidad dispersa es proporcional al cuadrado del modulo de una transformada de Fourier respecto de la perturbacion de la amplitud de dispersion asociada al defecto. De este modo pueden obtenerse datos sobre la distribucion espacial de la amplitud de dispersion por defectos realizando las mediciones pertinentes por dispersion neutronica y efectuando una inversion de Fourier. En la practica, dada la gran cantidad de procesos que contribuyen a la actividad de fondo debida a la dispersion difusa, solo se han podido realizar determinados tipos de mediciones. En particular, se han logrado progresos considerables en lo que respecta a los defectos magneticos de las sustancias ferromagneticas en las que la seccion eficaz magnetica puede controlarse cambiando la direccion de magnetizacion con respecto al vector de dispersion neutronica. De este modo, la dispersion de interes puede distinguirse de los efectos no magneticos como diferencia entre dos intensidades medidas. Un proceso que contribuye al fondo de dispersion difusa, en parte de caracter magnetico y que, por tanto, la mencionada tecnica no elimina, es la dispersion miiltiple de Bragg en un poli- cristal magnetico. Puede prevenirse utilizando una muestra monocristalina o empleando neutrones de gran longitud de onda, de forma que impidan los procesos de Bragg. En Harwell se ha construido un instrumento basado en este principio, que se utiliza para una amplia serie de mediciones en aleaciones ferromagneticas diluidas. Se examinan estos experimentos y otras novedades que cabe anticipar en la materia, entre ellas la medicion de la dispersion magnetica difusa en sales paramagneticas. El estudio de esta dispersion reviste enorme interes, pues proporciona informacion dilecta sobre la cantidad de spin transmitida por un ion magnetico a los ligandos que le rodean como resultado de la covalencia. (author) [Russian] Zadachej nastojashhej raboty javljaetsja rassmotrenie kak v principe, tak i s prakticheskoj tochki zrenija teh vidov dannyh, kotorye mozhno poluchit' v rezul'tate izuchenija neuprugogo diffuznogo rassejanija nejtronov. Vnimanie skoncentrirovano na teh sistemah, v kotoryh imeetsja razuporjadochen- noe raspolozhenie defektov, kazhdyj iz kotoryh mozhno uslovno schitat' ne podverzhennym vlijaniju drugih imejushhihsja defektov libo v rezul'tate razbavlenija, libo v rezul'tate otsutstvija zavisimosti ot okruzhenija. Pri jetih uslovijah intensivnost' rassejanija proporcional'na kvadratu modulja razlozhenija Fur'e po vozmushheniju v amplitude rassejanija, vyzvannomu defektom. Takim obrazom, dannye ob amplitude prostranstvennogo raspredelenija rassejanija defektov mogut byt' polucheny v rezul'tate vypolnenija sootvetstvujushhih izmerenij rassejanija nejtronov i proizvedenija preobrazovanija Fur'e. Na praktike, v svjazi s tem, chto bol'shoe kolichestvo processov igraet rol' v sozdanii fona diffuznogo rassejanija, izmerenija udalos' poka proizvesti v ogranichennom chisle oblastej. V chastnosti, znachitel'nye uspehi dostignuty v oblasti magnitnyh defektov v ferromagnitnyh telah, v kotoryh magnitnye sechenija mogut kontrolirovat'sja putem izmenenija napravlenija namagnichivanija v otnoshenii vektora rassejanija nejtronov. Takim obrazom, interesujushhee rassejanie mozhet byt' otdeleno ot nemagnitnyh jeffektov putem opredelenija raznicy mezhdu rezul'tatami dvuh izmerenij intensivnosti. Processom, igrajushhim rol' v sozdanii fona diffuznogo rasseja- njja, kotoryj javljaetsja otchasti magnitnym po svoemu harakteru i ne mozhet byt' pojetomu iskljuchen s pomoshh'ju vysheukazannogo metoda, javljaetsja brjeggovskoe rassejanie na magnitnom polikristalle. Jetot process mozhno ustranit' putem ispol'zovanija monokristallicheskih obrazcov ili takih dlinnovolnovyh nejtronov, pri kotoryh nevozmozhen brjeggovskij process. Pribor, osnovannyj na jetom principe, byl razrabotan v Harujelle i ispol'zovalsja dlja shirokogo kruga izmerenij, svjazannyh s razbavlennymi ferromagnitnymi splavami. Jeti voprosy rassmatrivajutsja vmeste s nekotorymi drugimi voprosami, kasajushhimisja vozmozhnyh budushhih razrabotok v jetoj oblasti. V chislo jetih poslednih vhodjat izmerenija diffuznogo magnitnogo rassejanija na paramagnitnyh soljah. Nabljudenie takogo rassejanija predstavljaet bol'shoj interes, poskol'ku pozvoljaet poluchit' neposredstvennye dannye o velichine spina, peredannoj v rezul'tate kovalentnosti ot magnitnogo iona k okruzhajushhim ego ligandam. (author)

  20. About the possibility to manufacture a 200 MeV Microtron, with a 50 μA average intensity and operating in quasi-steady regime; Sur la possibilite de realiser un Microtron de 200 MeV, de 50 μA d'intensite moyenne et fonctionnant en regime quasi-stationnaire

    Energy Technology Data Exchange (ETDEWEB)

    Bruck, H.; Leleux, G.; Proy, J.; Thirion, J.

    1958-12-15

    The authors report a preliminary study aimed at performing a rough assessment of the development and manufacturing of an electron accelerator (a 200 MeV Microtron with a 50 μA average intensity), and of the theoretical and technological difficulties, of the general characteristics and cost of such a development. After some generalities about the Microtron (principle, trajectory stability, operation on a sub-resonance, practical experiment, use of straight sections, ultimate limit of energy), the report addresses the issue of synchronism and phase stability. It proposes a description and an analysis of the accelerator device (required HF power, HF wavelength, shunt resistance, guide structure, efficiency optimum conditions, guide with recirculation, power of UHF tubes), discusses the choice of the main characteristics of the Microtron (injection energy and guide length, potential increase per lap), addresses the issues of beam focusing and guiding (Betatron oscillation). It finally reports an economic study which assesses the installation cost.

  1. Les possibilités d'utilisation ciblée des ressources de la Responsabilité Sociale des Entreprises dans le secteur vinier dans le but d'améliorer la durabilité et la spécificité culturelle des régions viticoles

    Directory of Open Access Journals (Sweden)

    Murdjeva Ivana

    2017-01-01

    Full Text Available Ces dernières années, la responsabilité corporative sociale (RCS marque une certaine croissance dans l'intérêt des entreprises envers l'intégration dans des causes d'intérêt social dans leurs pratiques commerciales. L'on note un intérêt accru envers les sujets liés à l'éducation, l'écologie, la santé, l'amélioration de la sensibilisation des consommateurs, l'amélioration des conditions de travail et, tout dernièrement, aux sujets et aux initiatives visant la conservation et la protection du patrimoine culturel matériel et immatériel. Diverses entreprises et producteurs, dans leur plupart de petite et moyenne envergure, dirigent leurs ressources vers un travail avec des groupes et des communautés locales, afin d'améliorer le milieu et de créer une motivation pour la conservation durable des emplois et l'augmentation de l'engagement professionnel et des compétences des personnes employées dans la production. Les secteurs publics ayant contact avec la culture, l'art, la préservation de l'identité et des tra-ditions manquent encore de popularité, y compris les productions spécifiques aux régions, la préservation du milieu et la conservation des phénomènes de la nature, la préservation de la culture des communautés locales et leur intégration dans un échange d'ordre global.

  2. A guide on the possibilities of increasing energy efficiency in the meat, poultry, beverage and milk processing industries; Guide sur les possibilites d'accroitre l'efficacite energetique dans l'industrie de la transformation des viandes et volailles, des boissons et de la transformation du lait

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-08-01

    This guide describes the potential for improving the energy effectiveness in Canada's agri-food sector. The food and beverage sector is the second most important manufacturing sector in Canada. Since 1998, it has ranked as the highest employer in Quebec. The sector consumed 29,050 GWh of electricity in 1998, with greenhouse gas emissions in the order of 3,800 kilo tonnes. This report referred specifically to energy efficiency measures that can be adopted for meat and poultry processing, beverage and beer production, and milk processing. It also described some aspects of water management, which is closely associated with energy use in the agri-food sector which relies heavily on hot water. Some promising innovations that can lead to energy savings include membrane filtration, cold pasteurization, heat pumps, and mechanical vapour re-compression. Energy savings can also be achieved through innovative heat transfer methods such as infrared, microwave, and heat induction. refs., tabs., figs.

  3. Possibility of observation by the Antares telescope of the gamma ray point sources observed by the Egret detector and study of a prototype; Possibilite d'observation par le telescope Antares des sources ponctuelles de rayons gamma observees par le detecteur Egret et etude d'un prototype

    Energy Technology Data Exchange (ETDEWEB)

    Saouter, S

    2004-09-01

    The ANTARES collaboration aims to install an underwater neutrino telescope at 2 500 m deep and 40 km away from Toulon (France). The neutrinos are detected thanks to their interaction by charged current in the medium surrounding the telescope which can be rock or water. The produced muon emits Tcherenkov light along its path in water. This light is detected by a three-dimensional network of 900 photomultipliers divided into 12 independent lines. To validate the chosen techniques, a prototype made up of a fifth of line was deployed in 2003. A reconstruction algorithm was developed on simulated data whose results are presented. However, a technical failure made the data recorded by the prototype unsuitable. The detection potential of Antares to gamma ray sources observed by Egret is studied. Indeed, under the assumption of a gamma ray production via high-energy hadrons, a comparable flux of neutrinos associated is predicted. By supposing the two fluxes equal and an energy spectrum varying as E{sup -2} eleven sources are potentially detectable in one year. The Antares sensitivity to such a spectrum depends on the declination of the source with an optimum of 3.6 10{sup -4} m{sup -2} s{sup -1} GeV{sup -1} in one year at 90% of confidence level for a declination of - 90 deg C. (author)

  4. Effect of cobalt-60 {gamma} radiation and of thermal neutrons on high resistance P and N silicon. Possibility of obtaining a nuclear compensation for P type silicon; Effects du rayonnement {gamma} du cobalt 60 et de neutrons thermiques sur du silicium P et N de haute resistivite. Possibilite de realiser une compensation nucleaire d'un silicium du type P

    Energy Technology Data Exchange (ETDEWEB)

    Messier, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-11-01

    Type P silicon has been compensated by the production of a controlled and uniform amount of donor atoms ({sup 31}P) using thermal neutrons to bring about a nuclear transformation. It is shown that it is possible in this way to reduce by a factor of about one hundred the overall concentration of residual ionised impurities in the purest crystals obtained by floating zone purification (2 x 10{sup 12} atoms/cm{sup 3}). The degree compensation obtained is limited by the initial inhomogeneity of acceptor impurities which have to be compensated. Lattice defects which still remain after prolonged annealings reduce the life-time of the material to about 10 {mu}s approximately. Particle detectors having thicknesses of 2 to 5 mm have been built by this process; they give good results, particularly at low temperatures. A study has also been made of the number and of the nature of lattice defects produced by thermal neutrons in high resistivity P and N type crystals. These defects have been compared to those produced by {gamma} rays from {sup 60}Co. A discussion is given of the validity of the Wertheim model concerning pronounced recombination at low temperatures (77 deg. K - 300 deg. K) of primary defect-interstitial pairs. The nature of the defects introducing energy levels into the lower half of the forbidden band has been studied. (author) [French] On a compense du silicium de type P en produisant, au moyen de neutrons thermiques, par transmutation nucleaire une quantite controlee et uniforme d'atomes donneurs ({sup 31}P). On montre qu'on peut ainsi reduire de cent fois environ la densite nette d'impuretes ionisees residuelles subsistant dans les cristaux les plus purs obtenus par purification par zone flottante (2.10{sup 12} atomes/cm{sup 3}). Le degre de compensation obtenu est limite par i'inhomogeneite initiale des impuretes acceptrices a compenser. Des defauts de reseau qui subsistent meme apres des recuits prolonges reduisent la duree de vie du materiau a 10 {mu}s environ. Des detecteurs de particules de 2 a 5 mm d'epaisseur ont ete realises par ce procede et donnent, particulierement a basse temperature, de bons resultats. Par ailleurs, on a etudie le nombre et la nature des defauts du reseau produits par les neutrons thermiques dans des cristaux de haute resistivite de types N et P. On les a compares a ceux produits par les rayons {gamma} du {sup 60}Co. On a discute la validite du modele de Wertheim relatif a une recombinaison tres importante a basse temperature (77 deg. K - 300 deg. K) des paires lacune-interstitiel primaires. On a etudie la nature des defauts introduisant des niveaux d'energie dans la moitie inferieure de la bande interdite. (auteur)

  5. Possibility of observing high energy neutrinos from gamma bursts, with the Antanares telescope, feasibility study; Possibilite d'observation, par le telescope antares, de neutrinos de haute energie associes aux sursauts gamma et validation des techniques de detection a l'aide d'un prototype

    Energy Technology Data Exchange (ETDEWEB)

    Kouchner, A

    2001-04-01

    The European Antares collaboration intends to build a deep-sea neutrino telescope with a detection surface of about 1/10 km{sup 2} in the Mediterranean sea. The universe is transparent to neutrinos, so their study provides a unique means of improving our knowledge of the nature and origin of cosmic rays and their emission from the most powerful astrophysical sources in the cosmos. Neutrinos also offer the possibility of opening a new energy window (E>TeV) for observation of the universe. The first part of the thesis is dedicated to a study of the possibility of using the future telescope to look for correlations between gamma-ray bursts and high-energy neutrinos. It is based, on one hand, on the predictions of neutrino fluxes from gamma-ray bursts in the framework of the theoretical model of 'fireballs', and, on the other hand, on the temporal properties of the gamma-ray bursts in the 4. BATSE catalogue. The second part of the thesis presents the results obtained with a prototype detector line deployed, at the end of 1999, some forty km south-west off Marseilles. The objective was to operate a complete apparatus, similar to the future detector lines, from the shore, and under realistic conditions. Data from 7 photomultiplier tubes disposed along the detector line were transmitted through 37 km of optical fiber to the shore, where they were used to reconstruct tracks due to atmospheric muons, thus validating the detection principles and methods. (author)

  6. The World's Present And Future Resources Of Protein Available For Human Nourishment, And The Possibilities For Utilizing These Resources; Les ressources mondiales actuelles et futures en proteines disponibles pour l'alimentation de l'homme - Leurs possibilites d'utilisation

    Energy Technology Data Exchange (ETDEWEB)

    Pion, R.; Fauconneau, G. [INRA, Centre National de Recherches Zootechniques, Jouy-en-Josas, Yvelines (France)

    1968-07-01

    Man must obtain from his food supply various essential and semi-essential amino acids, in combination with an adequate amount of non- differentiated nitrogen, necessary for satisfying his needs. These various essential amino acids are synthesized by land or aquatic plant organisms; the essential amino acids are for the most part taken up into the plant proteins, which are either consumed by man in their original state or transformed, with a rather low efficiency, into animal protein subsequently utilized by man. The protein resources available to man in those forms are now inadequate, and the increase in world population makes necessary both an increase in protein production and an improvement in the efficiency of protein utilization. A study of the various sources of nitrogenous food products and of their amino acid composition (the main factor in their quality) shows that there are a number of ways of increasing the resources available to man, both by the improvement of farming techniques and by the industrial-scale production of supplements. The principal methods of improving plant production are irrigation, use of fertilizers (especially nitrogenous ones) and genetic grain selection methods, with a view to obtaining better quality proteins from species now under cultivation and to utilizing plants of promising composition which are not yet being developed. The growing production and use of factory-produced supplements, particularly synthetic amino acids, should contribute to improved efficiency in the utilization of proteins of plant origin by monogastric species (man, pigs, poultry). Lastly, certain high-quality proteins (fish, milk) should be utilized directly by man on a larger scale. At the present stage of technology these proteins can be satisfactorily conserved. (author) [French] L'homme doit trouver dans son alimentation les differents acides amines indispensables et semi-indispensables, associes a une quantite suffisante d'azote indifferencie necessaire a la satisfaction de ses besoins. Ces differents acides amines indispensables sont synthetises par les organismes vegetaux terrestres ou aquatiques; les acides amines indispensables sont en majeure partie incorpores dans des proteines vegetales, qui sont soit consommees telles quelles par l'homme, soit transformees, avec un rendement assez faible, en proteines animales utilisees ulterieurement par l'homme. Les ressources en proteines ainsi mises a la disposition de l'homme sont actuellement insuffisantes et l'augmentation de la population mondiale rend necessaires aussi bien une augmentation de leur production qu'une amelioration du rendement de leur utilisation. L'inventaire des diverses sources de matieres azotees alimentaires et l'etude de leur composition en acides amines (principal facteur de qualite) montrent qu'il existe de nombreux moyens d'augmenter les ressources dont peut disposer l'homme, aussi bien par l'amelioration des techniques agricoles que par la fabrication de complements par l'industrie. La production vegetale peut etre amelioree surtout grace a l'irrigation, a l'utilisation d'engrais (en particulier azotes) et a l'amelioration genetique des graines, en vue de l'obtention de proteines de meilleure qualite a partir des especes actuellement cultivees aussi bien que de l'utilisation de plantes de composition interessante qui ne sont pas exploitees actuellement. La production et l'utilisation accrues de complements d'origine industrielle (acides amines de synthese notamment) doivent contribuer a ameliorer le rendement de l'utilisation des proteines d'origine vegetale par les monogastriques (homme, porc, volaille). Enfin, certaines proteines de bonne qualite (poissons, lait) devraient etre dans une plus grande proportion utilisees directement par l'homme. La technologie permet actuellement la bonne conservation de ces proteines. (author)

  7. Plan du site | CRDI - Centre de recherches pour le développement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Carrières · Possibilité de nomination · Possibilités d'emploi · Emplois pour étudiants · Ce que nous avons à offrir · Possibilité d'emploi avec le Conseil des gouverneurs du CRDI · Nouvelles et événements · Communiquez avec nous · Gouvernance · Conseil des gouverneurs · Gestion du Centre · Plan stratégique du CRDI.

  8. Profil bactériologique du pied diabétique et son impact sur le choix des antibiotiques

    Science.gov (United States)

    Zemmouri, Adil; Tarchouli, Mohamed; Benbouha, Abdellatif; Lamkinsi, Tarik; Bensghir, Mustapha; Elouennass, Mostafa; Haimeur, Cherqui

    2015-01-01

    Introduction Analyse du profil bactériologique des pieds diabétiques pris en charge à l'hôpital militaire de Rabat et son influence sur l'antibiothérapie de première intention. Méthodes Etude prospective non randomisée étalée sur 18 mois, ayant concerné 105 patients. Après recueil des données et en attente des résultats bactériologiques nos patients ont été divisés en deux groupes: un groupe a été mis sous Amoxicilline + Acide clavulanique + Gentamycine (59 patients) et un groupe sous Ertapénème±Gentamycine (46 patients). Résultats L’étude a regroupé 85 hommes et 20 femmes (sexe ratio = 4.26). L’âge moyen est de 64.4 ans. La gangrène a été observée chez 79% des malades; elle était humide-donc surinfectée en principe- dans 43% des cas. Par ailleurs, 67% des malades ont un chiffre de globules blancs 12000 définissant une infection sévère. L'ostéolyse a été mise en évidence chez 27% de nos patients. Parmi les différentes techniques de prélèvements: 81% ont été profonds dont 21% de biopsie osseuse per opératoire et 14% de prélèvements combinés. 42% de ces prélèvements sont poly microbiens et 21% sont stériles. Les résultats bactériologiques viennent confirmer la prédominance des bactéries aérobies à Gram positif. Le taux de remplacement de l'Ertapénème est de 22% contre un taux de 50% pour l'Amoxiclav. Conclusion L'antibiothérapie ne doit être instaurée qu'en cas d'infection du pied diabétique diagnostiquée sur les critères cliniques établis par les consensus internationaux récents. Le respect des mesures de lutte contre la diffusion de la résistance bactérienne s'avère primordiale. PMID:27386024

  9. White Book on means of extending the general tax on polluting activities to intermediary energy consumptions of enterprises; Livre blanc sur les modalites de l'extension de la taxe generale sur les activites polluantes aux consommations intermediaires d'energie des entreprises

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-11

    The government decided to engage France in a firm action of reducing the pollutant emission damaging the environment or producing the greenhouse effect. To this aim the taxation upon the consumptions of rare resources the use of which results in an important pressure upon environment, as the energy for instance, constitutes an essential complement to other tools, as for instance, regulations, technical norms, ecological labels, assistance for investments, etc. Thus the fiscal policy constitutes a perennial lever of inciting actors, particularly those acting in economy, to optimize and control their energy consumption or to reduce their greenhouse gas emission. Any pollutant emission avoided represents not only a supplementary protection of the environment but also, in time, the avoidance of a reparatory expenditure for the entire society. To this aim the Parliament has approved in 1999 the creation of a general tax on polluting activities (TGAP) intended to prevent first the local and diffuse pollutions which will be enlarged since 2001 to prevent the global pollutions, first of those resulting from greenhouse gas emissions. France engaged itself in the frame of Kyoto conference protocol, adopted in December 1997, to stabilize in 2010 its gas emissions to the level attained in 1990. Actually, taking into account the prospects for economic growth, this engagement needs supplementary efforts. The government's decision, announced last 20 May, of enlarging the TGAP since 2001 to intermediary energy consumptions, is a contribution to this objective. Concerned about the France industry competitiveness, namely to the particular situation of the intensive energy enterprises, exposed to international competition, the government judged advisable to proceed in a large consultation of the concerned economic actors before implementing this enlargement. The White Book makes this engagement concrete. The accuracy of the answers given to the questions, posed in its second part, will allow clarifying the choices of the government in implementing this reform. Tool of inciting and preventing, the enlarged TGAP, allows add to the dividends obtained for environmental protection the resources of a second dividend, the dividend for employment. By substituting for other mandatory taxes pressing on labour, the TGAP will be entirely allotted to lower the social employment quotas. The document presents the government's program, introduces the principles of ecological fiscal policy and the topics of greenhouse effect.

  10. White paper on renewable energies. Choices to found our future. The contribution of renewable energy syndicate to the debate related to the energy policy; Le livre blanc des energies renouvelables. Des choix qui fondent notre avenir. la contribution du syndicat des energies renouvelables au debat relatif a la politique energetique

    Energy Technology Data Exchange (ETDEWEB)

    Bal, J.L.

    2012-02-15

    In this document the Renewable Energy Syndicate proposes a road map to boost the French industrial dynamics and meet the challenges of world energy transition. The authors outline the strong growth of the renewable energy market despite the crisis context, and that France can be in the pace. They propose a road map for the 2020-2030 period, and highlight the need to build up a strategy. In a second part, twelve propositions are made to boost the ground-based wind energy, to develop offshore wind and marine energy, to rebuild the photovoltaic sector, to take advantage of hydroelectricity assets, to extent the development of renewable heat (biomass, geothermal, thermal solar energy), to place renewable energies at the heart of the building and struggle against fuel poverty, to create new industrial sectors, to exploit all biomass energy potentials, to facilitate the input of renewable energies on electric grids, to reach energy autonomy in ultramarine areas, to consolidate the renewable energy industry, and to aim at an international development

  11. Concept and measure of improved equity: attempt of implementation to the 'blue-white-red' tariff option of EDF; Concept et mesure d'equite amelioree: tentative d'application a l'option tarifaire ''bleu-blanc-rouge'' d'EDF

    Energy Technology Data Exchange (ETDEWEB)

    Bezzina, J. [Montpellier-1 Unirv. Faculte des Sciences Economiques, Centre de Recherche en Economie et Droit de l' Energie - ATER - CREDEN, 34 (France)

    1997-12-01

    The issue of cross-subsidies and cost allocation practices concerns a large part of debates facing the deregulation of electric public utilities. The first aim of this paper is to deal with the regulation of an electric multi-product monopoly in association with equity and efficiency dimensions. To this end, we develop a concept and measure of improved equity. From a practical point of view, we also try to compute improved equity measurement considering the case of EDF tariff for domestic customers. (author)

  12. Study of neutrino production in the Cannonball model of Gamma ray bursts: possibility of observation of these neutrinos with the Antares neutrinos telescope, and study of the optical background recorded with the prototype sector line; Etude de la production de neutrinos associes aux Sursauts Gamma dans le modele du Boulet de canon: possibilite d'observation de ces neutrinos par le detecteur ANTARES, et etude du bruit de fond optique enregistre par le prototype d'un secteur de ligne

    Energy Technology Data Exchange (ETDEWEB)

    Ferry, S

    2004-09-15

    ANTARES is a future neutrino telescope which will be build at 40 km off the french coast (Toulon), at a 2500 m depth. The interaction of a neutrino with matter produces a muon which emits Cerenkov light while propagating in water. This light is detected with 900 photomultipliers distributed over 12 lines. Gamma ray bursts (GRB) are violent cosmological phenomenon observed once per day. In the Cannonball Model, bursts are produced by the interaction of a jet made of cannonballs (CB) with a supernova remnant (SNR). Forward shocks propagate in the SNR, reverse ones in the CB and neutrinos are produced at the shock fronts. An estimation of the neutrino production is given and is studied over a large parameter range. For a typical GRB, 0.002 to 0.3 v{sub {mu}}, cm{sup -2} can be produced. Depending on the viewing angle, ANTARES could detect 1 to 10 v{sub {mu}} per year in correlation with GRBs. The ambient optical background has been recorded by the ANTARES prototype sector line. The analysis is about the background influence on the detector performance and about the organisms activity which produces it. For example, it appears a 17.6 to 20.4 h periodicity which is compatible with the liquid masses movement imposed by the Coriolis force at the ANTARES latitude. (author)

  13. Ovarian Mature Cystic Teratoma Containing Multiple Mobile

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Hyun Sun; Yoon, Seong Eon; Lee, Young Hwan; Kim, Hye Won; Yoon, Kwon Ha [Wonkwang University Hospital, Iksan (Korea, Republic of); Park, Seong Hoon [Asan Medical Center, Seoul (Korea, Republic of)

    2006-12-15

    A 48-year-old woman was admitted to our hospital with a palpable mass in her lower abdomen. A left ovarian, cystic mass containing multiple mobile globules was seen on CT and MR images. The outer portion of the globules showed fat components on CT and fat-saturated T1-weighted MR images. Ultrasonography showed multiple echogenic, mobile globules with some sound attenuation and hyper echoic lines and dots within the cystic mass, which corresponded with the presence of lipid globules and hair shafts of ovarian mature cystic teratoma, respectively

  14. Ovarian Mature Cystic Teratoma Containing Multiple Mobile

    International Nuclear Information System (INIS)

    Cho, Hyun Sun; Yoon, Seong Eon; Lee, Young Hwan; Kim, Hye Won; Yoon, Kwon Ha; Park, Seong Hoon

    2006-01-01

    A 48-year-old woman was admitted to our hospital with a palpable mass in her lower abdomen. A left ovarian, cystic mass containing multiple mobile globules was seen on CT and MR images. The outer portion of the globules showed fat components on CT and fat-saturated T1-weighted MR images. Ultrasonography showed multiple echogenic, mobile globules with some sound attenuation and hyper echoic lines and dots within the cystic mass, which corresponded with the presence of lipid globules and hair shafts of ovarian mature cystic teratoma, respectively

  15. Rapid Precipitation of Amorphous Silica in Experimental Systems with Nontronite (NAu-1) and Shewanella oneidensis MR-1

    National Research Council Canada - National Science Library

    Furukawa, Yoko; O'Reilly, S. E

    2007-01-01

    ...) silica globule formation was confirmed in the immediate vicinity of bacterial cells and extracellular polymeric substances in all experimental systems that contained bacteria, whether the bacteria...

  16. THE BIOCIDE TRIBUTYLTIN ALTERS TESTOSTERONE ESTERIFICATION IN MUD SNAILS (ILYANASSA OBSOLETA)

    Science.gov (United States)

    The Biocide Tributyltin Alters Testosterone Esterification in Mud Snails (Ilyanassa obsoleta)Meredith P. Gooding and Gerald A. LeBlanc Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695-7633Tributyltin (TBT...

  17. Hudozhnik namerevalsja võkrasit Monblan

    Index Scriptorium Estoniae

    2007-01-01

    Mont Blanci mäetipu roosaks värvida kavatsenud Tšiili päritolu taani avangardikunstnik Marco Evaristti peatati prantsuse politseinike poolt. Kunstniku kommentaarid kunstiprojektile Mont Blanc Project

  18. AMANE D.mdi

    African Journals Online (AJOL)

    lara

    SECHAGE. 2 - 3 jours. BROYAGE. FARINE. EAU. DECANTATION. 5 - 10 min. SURNAGEANT 1. DEPOT ET. FLOCULANT BLANC. SUBSTANCE. VISQUEUSE. EAU. PRECUISSON. 1 – 2 h. BARRIQUE. SUBSTANCE. VISQUEUSE. DECANTATION. 12 h. MELANGE. DECANTATION. 10 - 15 min. DEPOT. SURNAGEANT 2.

  19. Effect of iron deficiency on the localization of phosphoenolpyruvate ...

    African Journals Online (AJOL)

    reading 7

    2012-05-08

    May 8, 2012 ... under iron deficiency of two common bean cultivars: Flamingo tolerant and Coco blanc sensitive to iron ... protein represents at least 1% of the nodule soluble ..... fact, bacteroids need to obtain organic compounds and.

  20. An Overview of Grain Growth Theories for Pure Single Phase Systems,

    Science.gov (United States)

    1986-10-01

    the fundamental causes for these distributions. This Blanc and Mocellin (1979) and Carnal and Mocellin (1981j set out to do. 7.1 Monte-Carlo Simulations...termed event B) (in 2-D) of 3-sided grains. (2) Neighbour-switching (termed event C). Blanc and Mocellin (1979) dealt with 2-D sections through...Kurtz and Carpay (1980a). 7.2 Analytical Method to Obtain fn Carnal and Mocellin (1981) obtained the distribution of grain coordination numbers in

  1. JPRS Report Near East & South Asia

    Science.gov (United States)

    1991-02-22

    streets of Yerevan has not forgotten the past and the genocide and keeps his eyes fixed on Mount Ararat . Birand is not mistaken. It is Yesayi...five frozen accounts—Lotus, Tulip, Mont Blanc, Svenska Inc and an unidentified account—be passed on to the Indian investigators. Even if the Cantonal...accounts of ’Tulip,’ ’Lotus’ and ’ Mont Blanc’ (these are accused numbers 11, 12 and 13 respectively), and certain public servants of the government

  2. Developpement d'une methode calorimetrique de mesure des pertes ac pour des rubans supraconducteurs a haute temperature critique

    Science.gov (United States)

    Dolez, Patricia

    supraconductrice qui restent fixes a l'interface coeur-enveloppe, et le revetement en alliage d'argent. L'interet d'une methode calorimetrique par rapport a la technique electrique, plus rapide, plus sensible et maintenant fiable, reside dans la possibilite de realiser des mesures de pertes ac dans des environnements complexes, reproduisant la situation presente par exemple dans un cable de transport d'energie ou dans un transformateur. En particulier, la superposition d'un courant dc en plus du courant ac habituel nous a permis d'observer experimentalement, pour la premiere fois a notre connaissance, un comportement particulier des pertes ac en fonction de la valeur du courant dc decrit theoriquement par LeBlanc. Nous avons pu en deduire la presence d'un courant d'ecrantage Meissner de 16 A, ce qui nous permet de determiner les conditions dans lesquelles une reduction du niveau de pertes ac pourrait etre obtenue par application d'un courant dc, phenomene denomme "vallee de Clem".

  3. Monte Carlo simulation of AB-copolymers with saturating bonds

    DEFF Research Database (Denmark)

    Chertovich, A.C.; Ivanov, V.A.; Khokhlov, A.R.

    2003-01-01

    Structural transitions in a single AB-copolymer chain where saturating bonds can be formed between A- and B-units are studied by means of Monte Carlo computer simulations using the bond fluctuation model. Three transitions are found, coil-globule, coil-hairpin and globule-hairpin, depending...

  4. Biologically produced sulfur

    NARCIS (Netherlands)

    Kleinjan, W.E.; Keizer, de A.; Janssen, A.J.H.

    2003-01-01

    Sulfur compound oxidizing bacteria produce sulfur as an intermediate in the oxidation of hydrogen sulfide to sulfate. Sulfur produced by these microorganisms can be stored in sulfur globules, located either inside or outside the cell. Excreted sulfur globules are colloidal particles which are

  5. Petroleum under the microscope

    Energy Technology Data Exchange (ETDEWEB)

    Scott, J

    1920-01-01

    Kerogen may have been formed by a gradual change of vegetable matter into kerogen globules that were intimately mixed with clay and other minerals. As these globules accumulated, the more volatile constituents were eliminated, leaving the remainder as a heavy residue. This process is termed inspissation.

  6. Introduzione all'analisi e all'algebra analisi

    CERN Document Server

    1983-01-01

    La OPEN UNIVERSITY inglese è un'universita autonoma a tutti gli effetti, il cui scopo è di offrire a chiunque la possibilità di conseguire una laurea indipendentemente dalla preparazione posseduta.

  7. Etude de l’hémogramme dans la drépanocytose homozygote: à propos de 87 patients

    Science.gov (United States)

    Dahmani, Fatima; Benkirane, Souad; Kouzih, Jaafar; Woumki, Aziz; Mamad, Hassan; Masrar, Azlarab

    2016-01-01

    thrombocytose. Une leucocytose était observée chez 64.4% des patients et 80.5% ont présenté une neutropénie. Les paramètres de l’hémogramme serviront de base de comparaison lors des crises et permettront d’évaluer l’efficacité de la prise en charge par le clinicien. Les valeurs élevées des globules blancs, plaquettes et CCHM semblent déterminants dans l’expression sévère de la drépanocytose au Maroc. Le profil hématologique du drépanocytaire marocain montre des données semblables à celles rapportées en littérature chez ceux de l’Afrique centrale, avec une leucocytose. Les résultats de notre étude suggèrent que, la drépanocytose est un problème de santé le plus fréquent chez les marocains et que nos résultats sont comparables à ceux décrits dans le syndrome drépanocytaire majeur. PMID:28293356

  8. Energy density of marine pelagic fish eggs

    DEFF Research Database (Denmark)

    Riis-Vestergaard, J.

    2002-01-01

    Analysis of the literature on pelagic fish eggs enabled generalizations to be made of their energy densities, because the property of being buoyant in sea water appears to constrain the proximate composition of the eggs and thus to minimize interspecific variation. An energy density of 1.34 J mul......(-1) of total egg volume is derived for most species spawning eggs without visible oil globules. The energy density of eggs with oil globules is predicted by (σ) over cap = 1.34 + 40.61 x (J mul(-1)) where x is the fractional volume of the oil globule. (C) 2002 The Fisheries Society of the British...

  9. Sub-aqueous sulfur volcanos at Waiotapu, New Zealand

    Energy Technology Data Exchange (ETDEWEB)

    Grimes, S.; Rickard, D. [University of Wales, Cardiff (United Kingdom). Dept. of Earth Sciences; Browne, P.; Simmons, S. [University of Auckland (New Zealand). Geothermal Institute and Geology Dept.; Jull, T. [University of Arizona, Tucson (United States). AMS Facility

    1999-12-01

    Exhumed, sub-aqueous sulfur mounds occur in the Waiotapu geothermal area, New Zealand. The extinct mounds are < 2 m high and composed of small (< 0.5 cm) hollow spheres, and occasional teardrop-shaped globules. They are located within a drained valley that until recently was connected to Lake Whangioterangi. They were formed a maximum of 820 {+-} 80 years BP as a result of the rapid sub-aqueous deposition of sulfur globules, formed when fumarolic gases discharged through molten sulfur pools. Similar globules are now being formed by the discharge of fumarolic gases through a sub-aqueous molten sulfur pool in Lake Whangioterangi. (author)

  10. Possibilidades de inserção da pesquisa contábil brasileira no cenário internacional: uma proposta de avaliação dos periódicos científicos de contabilidade e auditoria publicados em língua inglesa e disponibilizados no portal de periódicos da CAPES Possibilites for inserting brazilian accounting research in the international scenario: a proposal for the assessment of scientific accountancy and auditing journals published in english and available in the CAPES journal portal

    Directory of Open Access Journals (Sweden)

    Fernando Dal-Ri Murcia

    2008-04-01

    Full Text Available O objetivo deste trabalho é propor uma metodologia de avaliação para os periódicos científicos de contabilidade e auditoria publicados em língua inglesa e disponibilizados no Portal de Periódicos da CAPES. A justificativa para a realização deste estudo baseia-se em duas premissas: a necessidade de uma inserção internacional da pesquisa contábil brasileira e a inexistência de uma avaliação pela CAPES dos periódicos estrangeiros. As revistas acadêmicas que continham as palavras accounting ou auditing em seus títulos foram selecionadas. Após a eliminação dos periódicos não-acadêmicos, 40 journals foram analisados. A coleta dos dados foi realizada principalmente nos sites eletrônicos de cada periódico e envolveu a análise dos seguintes aspectos: corpo editorial (editorial board e sua internacionalização, instrução para os autores (guide for authors, enfoque (aim/focus, revisão às cegas (blind review, indexação ao SCOPUS, indexação ao Institute of Scientifc Information, grau de impacto de acordo com o Journal Citation Report e índice de temporalidade. Para se coletarem as informações referentes à taxa de corte (cut rate, foram enviados e-mails aos editores responsáveis (chief editor de cada periódico. Com base nos critérios propostos, 8 revistas foram classificadas com o conceito "A", 20 com "B" e 12 com "C", sendo que o Journal of Accounting Research (JAR, o Journal of Accounting and Economics (JAE, e o The Accounting Review (TAR foram os três periódicos com maior pontuação. Esta pesquisa visa contribuir para o desenvolvimento da pesquisa contábil brasileira à medida que propõe uma metodologia alternativa para avaliação de periódicos científicos.This paper aims to propose a methodology to evaluate accounting and auditing journals published in English and available in the CAPES Journal Portal. The research is justified by two basic premises: Brazilian accounting research needs international penetration and foreign journals have not been evaluated by CAPES yet. This study sample is composed of the journals that had the words accounting and auditing in their title. Non-academic journals were not analyzed and the final sample consisted of 40 journals. Data were collected from the journals websites and involved an analysis of the following aspects: editorial board, instructions for authors, aim/focus, blind review, indexation in SCOPUS and Institute for Scientific Information, Journal of Citation Report impact factor and temporality ratio. To collect information on the journals cut rate, e-mails were sent to the chief editors. Based on the proposed methodology, 8 journals received an "A" concept, 20 "B" and 12 "C". The three best evaluated journals according to this study are: Journal of Accounting and Economics (JAE, Accounting Organization and Society (AOS and The Accounting Review (TAR. This paper aims to contribute to Brazilian literature by proposing an alternative methodology for scientific journal evaluation.

  11. Comparison of total polyphenols content and antioxidant potential of wines from ‘Welschriesling’ and ‘Sauvignon Blanc’ varieties during ageing on fine lees

    Directory of Open Access Journals (Sweden)

    Jasna Lužar

    2016-10-01

    Full Text Available Phenolic compounds are key components of wine, since they contribute to wine characteristics such as colour, astringency and bitterness. They also act like antioxidants, with mechanisms involving free-radical scavenging that could prevent cardiovascular diseases and cancer. The aim of the present work was to compare the obtained results of total polyphenols content and antioxidant potential (AOP of several white wines (welschriesling and sauvignon blanc during ageing on fine lees. The total polyphenols content decreased in average for 16.1 % in welschriesling wines and for 18.7 % in sauvignon blanc wines in the period of three months of wine ageing on lees. In the same period AOP of wines decreased in average for 16.0 % in welschriesling wines and for 8.0 % in sauvignon blanc wines. Expectedly, the samples with added oak chips in grape must had higher antioxidant potential than others.

  12. AFSC/ABL: Embryonic development of quillback rockfish

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Maternal effects on the quality of progeny can have direct impacts on population productivity. Rockfish are viviparous and the oil globule size of larvae at...

  13. Emulsifying Formulation of Rosuvastatin Calcium for Improved ...

    African Journals Online (AJOL)

    solubility study, liquid formulations were prepared using LAS/Capryol 90: Maisine 35-1 as oil phase and. Tween 20 with ... evaluated for globule size, zeta potential, and emulsion properties. ..... surfactants which decreases the electrostatic.

  14. Comprehensive proteomic analysis of human milk-derived extracellular vesicles unveils a novel functional proteome distinct from other milk components

    NARCIS (Netherlands)

    van Herwijnen, Martijn J C; Zonneveld, Marijke I; Goerdayal, Soenita; Nolte-'t Hoen, Esther N M; Garssen, Johan; Stahl, Bernd; Altelaar, A F Maarten; Redegeld, Frank A; Wauben, Marca H M

    2016-01-01

    Breast milk contains several macromolecular components with distinctive functions, whereby milk fat globules and casein micelles mainly provide nutrition to the newborn, while whey contains molecules that can stimulate the newborn's developing immune system and gastrointestinal tract. Although

  15. La matière grasse du lait de dromadaire : composition, microstructure et polymorphisme. Une revue

    Directory of Open Access Journals (Sweden)

    Karray Nadia

    2005-09-01

    Full Text Available In camel milk, fat, that represents about 3.6% of the composition, is dispersed in the form of globules, enveloped in a membrane, derived from the secreting cell and constituted by phospholipidprotein complexes. This review examines the present state of knowledge of the dromedary milk fat. The topics dealt with are : composition (fatty acids and triacylglycerols, microstructure, fat globule size distribution and polymorphism (thermal and structural properties.

  16. 2748-IJBCS-Article-Diaby Vandjiguida

    African Journals Online (AJOL)

    hp

    hemoglobin), MCHC (Mean corpuscular hemoglobin concentration)). Les valeurs des globules rouges, de l'hémoglobine, des hématocrites (Tableau I) ont été significativement diminuées (p<0,001) chez les femelles comme chez les mâles. Chez les mâles, la diminution des globules rouges est plus significative à la dose 5 ...

  17. Small angle X-ray scattering study on the conformation of polystyrene in the anti-solvent process of supercritical fluids

    International Nuclear Information System (INIS)

    Liu Yi; Wang Hongli; Zhao Xin; Chen Na; Li Dan; Liu Zhimin; Han Buxing; Rong Lixia; Zhao Hui; Wang Jun; Dong Baozhong

    2003-01-01

    The conformation of polystyrene in the anti-solvent process of supercritical fluids (compressed CO 2 + polystyrene + tetrahydrofuran) is studied by synchrotron radiation X-ray small angle scattering (SAXS). Coil-to-globule transform of polystyrene chain is observed with increasing the concentration of CO 2 . It is found that polystyrene coils at the pressure lower than cloud point pressure (p c ) and changes into globule with uniform density at the pressure higher than p c

  18. Communication: Polarizable polymer chain under external electric field in a dilute polymer solution.

    Science.gov (United States)

    Budkov, Yu A; Kolesnikov, A L; Kiselev, M G

    2015-11-28

    We study the conformational behavior of polarizable polymer chain under an external homogeneous electric field within the Flory type self-consistent field theory. We consider the influence of electric field on the polymer coil as well as on the polymer globule. We show that when the polymer chain conformation is a coil, application of external electric field leads to its additional swelling. However, when the polymer conformation is a globule, a sufficiently strong field can induce a globule-coil transition. We show that such "field-induced" globule-coil transition at the sufficiently small monomer polarizabilities goes quite smoothly. On the contrary, when the monomer polarizability exceeds a certain threshold value, the globule-coil transition occurs as a dramatic expansion in the regime of first-order phase transition. The developed theoretical model can be applied to predicting polymer globule density change under external electric field in order to provide more efficient processes of polymer functionalization, such as sorption, dyeing, and chemical modification.

  19. Composition of primary cosmic rays near 10/sup 7/GeV from multiple underground muons

    Energy Technology Data Exchange (ETDEWEB)

    Bergamasco, L; D' Ettorre Piazzoli, B; Mannocchi, G [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica

    1980-01-19

    The results on the rate of parallel penetrating particles at the Mt. Blanc Station (approximately 4300 hg.cm/sup -2/) compared with the predictions of the scaling model are in favour of a mean mass A approximately 10-30 for primary cosmic rays at >=10/sup 7/ GeV.

  20. What Are Robespierre and Telemachus Doing in Saint-Domingue?

    DEFF Research Database (Denmark)

    Kjærgård, Jonas Ross

    2018-01-01

    Charles Pigault-Lebrun's play Le blanc et le noir (1795) is one of only a handful of French revolutionary plays to stage the Saint-Domingue slave rebellion, a rebellion today better known as the Haitian Revolution (1791–1804). I argue that Pigault-Lebrun uses early melodramatic generic traits to ...

  1. Pain Relief for Budget Cuts.

    Science.gov (United States)

    Fultz, David A.

    1983-01-01

    The Grand Blanc (Michigan) Community School District sets budget priorities by (1) surveying students, taxpayers, and teachers to learn their preferences for current programs and services; (2) determining the costs of state-mandated programs; (3) listing nonmandated programs and determining their costs; and (4) considering proposed new programs.…

  2. Chemometric investigation of the volatile content of young South African wines

    NARCIS (Netherlands)

    Weldegergis, B.T.; Villiers, de A.; Crouch, A.M.

    2011-01-01

    The content of major volatiles of 334 wines of six different cultivars (Sauvignon Blanc, Chardonnay, Pinotage, Shiraz, Cabernet Sauvignon and Merlot) and vintage 2005 was used to investigate the aroma content of young South African wines. Wines were sourced from six different regions and various

  3. Books Reviews La UE ante su presente inmediato: de la rectificación obligatoria a los retos ineludibles

    Directory of Open Access Journals (Sweden)

    Alfredo Crespo Alcázar

    2015-12-01

    Full Text Available Blanc Altemir, Antonio La Unión Europea y los BRICS (Brasil, Rusia, India, China y Sudáfrica Thomson Reuters Aranzadi, 2015 212 págs. Hewitt, Gavin Europa a la deriva Alianza Editorial, 2015 358 págs.

  4. Special issue of International journal of human resource management: Conceptual and empirical discoveries in successful HRM implementation

    OpenAIRE

    Mireia Valverde; Tanya Bondarouk; Jordi Trullen

    2016-01-01

    Special issue of International journal of human resource management: Conceptual and empirical discoveries in successful HRM implementation DOI: 10.1080/09585192.2016.1154378 URL: http://www.tandfonline.com/doi/full/10.1080/09585192.2016.1154378 Filiació URV: SI Inclòs a la memòria: SI Paraules clau en blanc [No abstract available

  5. New Year’s reception at the Globe

    CERN Multimedia

    2009-01-01

    CERN Director-General Rolf Heuer welcoming Carlo Lamprecht (left), Chairman of the Geneva Diplomatic Club, former State Counsellor of Geneva and former CERN staff member, and Etienne Blanc (right), Deputy-Mayor of Divonne-les-Bains and Chairman of the Community of communes of the Pays de Gex.

  6. Unexpected observations of muons from Cygnus X-3

    International Nuclear Information System (INIS)

    Elbert, J.W.

    1986-01-01

    One surface experiment (Kiel) and two underground experiments (Soudan and Mt. Blanc) have detected unexpectedly large fluxes of cosmic ray muons from the approximate direction of Cygnus X-3, with signals showing the precise period of the system. The muon signals cannot be produced by any known type of elementary particle unless unexpected processes are involved

  7. Tanzanie | Page 9 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Salaam, le ronflement des 50 machines à coudre est aussi tenace que le vrombissement d'insectes. Les ouvriers cousent des filets bleus, verts et blancs qui ont été tissés sur les métiers de la manufacture. Ces hommes et ces femmes font partie ...

  8. A new bioactive ursane-type triterpenoid from Croton ...

    Indian Academy of Sciences (India)

    blance of the leaves and flower cymes to that of Tulsi, this plant is often called Ban Tulsi locally. C. bon- plandianum was reported to have many medicinal uses including the repellent property against the insects,2–5 mosquito, A. aegypti.6 Local people in the remote area of West Bengal, India are using its root against snake.

  9. L'interdisciplinarite en sciences sociales pour l'etude du contact des langues (Interdisciplinarity in Social Sciences of the Study of the Relationships of Languages). Proceedings of a Colloquium of the International Center for Research on Bilingualism and the Institute for Interethnic and Intercultural Studies and Research (2nd, Quebec City, Quebec, Canada, October 1-5, 1984).

    Science.gov (United States)

    Prujiner, Alain, Ed.

    Papers given at an international conference applying the social sciences to the study of the relationships of languages include the following: "Reseaux sociaux et comportements langagiers en milieu de contact des langues" ("Social Networks and Language Behaviors in a Language Contact Setting") by M. Blanc and J. Hamers, with…

  10. Foreign Language Teaching and Cultural Identity.

    Science.gov (United States)

    Nasr, Raja T., Ed.; And Others

    A collection of works on the role of cultural identity in second language learning and teaching includes: "Linguas estrangeiras e ideologia" (Roberto Ballalai); "Cultural Identity and Bilinguality" (Josiane F. Hamers, Michel Blanc); "Foreign Language Teaching and Cultural Identity" (Lakshmie K. Cumaranatunge);…

  11. Priit Tenderi film sai Dresdenis auhinna

    Index Scriptorium Estoniae

    2002-01-01

    Dresdeni 14. filmifestivali animafilmide kategoorias sai teise preemia Priit Tenderi joonisfilm "Mont Blanc". Peapreemia sai saksa režissööri Jonathan Hodgsoni film "Camouflage". Kolmas oli PÖFFi peaauhinna saanud Stepan Birjukovi "Sossedi". Osales ka Nukufilmis diplomitööna valminud Jelena Girlini "Guff"

  12. Riho Unt lühifilmide festivali žüriis

    Index Scriptorium Estoniae

    2002-01-01

    Nukufilmide režissöör on 1.-9.veebruarini Prantsusmaal Clermont-Ferrand'i lühifilmide festivali žürii liige. Tema nukufilmid Saamueli seklustest on valitud festivali eriprogrammi. Võistlusprogrammi kuulub Priit Tenderi joonisfilm "Mont Blanc"

  13. Where protons will play The new supercollider that is poised to shake up physics

    CERN Multimedia

    Holt, Jim

    2007-01-01

    Near the foot of Mont-Blanc, the greatest of the Alpine peaks, a sizable object is taking shape, also quite beautiful in its way, yet not at all dumb. In fact, its pristine geometries may be instrumental in revealing what have hitherto been some of nature's deepest secrets. (2 pages)

  14. Characterisation of Saccharomyces cerevisiae hybrids selected for ...

    African Journals Online (AJOL)

    Wine yeasts (Saccharomyces cerevisiae) vary in their ability to develop the full aroma potential of Sauvignon blanc wine due to an inability to release volatile thiols. Subsequently, the use of 'thiolreleasing' wine yeasts (TRWY) has increased in popularity. However, anecdotal evidence suggests that some commercially ...

  15. ANTIANDROGENIC EFFECTS OF VINCLOZOLIN ON MALE RATS ARE PARTIALLY ATTENUATED BY TESTOSTERONE PROPIONATE

    Science.gov (United States)

    ANTIANDROGENIC EFFECTS OF VINCLOZOLIN ON MALE RATS ARE PARTIALLY ATTENUATED BY TESTOSTERONE PROPIONATECynthia Wolf1,2 , Joe Ostby1, Jonathan Furr 1, Gerald A. LeBlanc2, and L. Earl Gray, Jr.11 US Environmental Protection Agency, NHEERL, RTD, RTP, NC 27711, 2 Departmen...

  16. CHARACTERIZATION OF THE PERIOD OF SENSITIVITY OF FETAL MALE SEXUAL DEVELOPMENT TO VINCLOZOLIN

    Science.gov (United States)

    Characterization of the period of sensitivity of fetal male sexual development to vinclozolin.Wolf CJ, LeBlanc GA, Ostby JS, Gray LE Jr.Endocrinology Branch, MD 72, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U....

  17. Suured lootused / Jaanus Noormets

    Index Scriptorium Estoniae

    Noormets, Jaanus

    2007-01-01

    Ameerika Ühendriikide komöödiaseriaalis "Sõbrad" (1994-2004) mänginud näitleja Matt LeBlanc mängib nimiosa seriaalis "Joey", mis nagu jätkaks eelmise seriaali ühe tegelase elu edasist kujutamist. Sama : Teleleht nr. 11, lk. 38 : ill

  18. Characterisation of Saccharomyces cerevisiae hybrids selected for ...

    African Journals Online (AJOL)

    HartR

    2016-09-21

    Sep 21, 2016 ... hybrids for the production of Sauvignon blanc wine with enhanced fruity and .... 2013) with the principal components (PC's) as factors (that is, F1 .... Cluster VI: NH 8, NH 50, NH 71, NH 42, NH 53; Cluster VII: FERMICRU 4F9,.

  19. Intensive Behavioral Treatment of Urinary Incontinence of Children with Autism Spectrum Disorders: An Archival Analysis of Procedures and Outcomes from an Outpatient Clinic

    Science.gov (United States)

    Hanney, Nicole M.; Jostad, Candice M.; LeBlanc, Linda A.; Carr, James E.; Castile, Allison J.

    2013-01-01

    LeBlanc, Crossett, Bennett, Detweiler, and Carr (2005) described an outpatient model for conducting intensive toilet training with young children with autism using a modified Azrin and Foxx, protocol. In this article, we summarize the use of the protocol in an outpatient setting and the outcomes achieved with a large sample of children with autism…

  20. 21 CFR 82.2051 - Lakes (Ext. D&C).

    Science.gov (United States)

    2010-04-01

    ...). (a)(1) General. Any lake made by extending on a substratum of alumina, blanc fixe, gloss white, clay... two or more of these (i) one of the straight colors hereinbefore listed in this subpart, which color... salt prepared from one of the straight colors hereinbefore listed in this subpart by combining such...

  1. The Physical Basis of the Ionosphere in the Solar-Terrestrial System.

    Science.gov (United States)

    1981-02-01

    Hill (Evans, 1972), Saint-Santin ( Testud et al., 1975 ; Blanc, 1978, 1980 a, b), and also at the magnetic equator at Jicamarca (Fejer et al., 1979...1976, 3. Geophys. Res., 8* 7-40, 1979. Southwood, D.3., The role of hot plasma in magnetosphere convection, 3. GeophYs Res., 82, 5512, 1977. Testud , 3

  2. Valorisation de chaleur à bas niveau thermique Upgrading Low-Thermal-Level Heat

    OpenAIRE

    Cohen G.; Rojey A.

    2006-01-01

    La mise en oeuvre à la fois de cycles thermodynamiques et de fluides adaptés permet d'élargir considérablement les possibilités de récupération et de valorisation de la chaleur à bas niveau contenue dans les rejets thermiques industriels, l'eau géothermale, le rayonnement solaire ou le milieu environnant. Ceci permettra une meilleure préservation des ressources énergétiques dans les principaux secteurs consommateurs d'énergie : résidentiel, tertiaire et industriel. On décrit les possibilités ...

  3. Environnements de tests d’intrusion pour mobiles et tablettes

    OpenAIRE

    Vianin, Jérémie; Bocchi, Yann

    2017-01-01

    L’objectif de ce travail est de réaliser une recherche des possibilités actuelles de tests d’intrusion mobiles. Après avoir recherché les technologies existantes, nous les analysons et les comparons afin de proposer un outil complet. Dans ce travail, nous analysons les possibilités de pentesting mobile avec l’aide d’une tablette de la marque Nexus et un smartphone de la gamme One d’HTC. Nous voyons le pentest mobile sous trois grands angles : OS, package et application.

  4. INVESTIGATION OF THE RELATIONSHIP OF THE STATISTICAL MOMENTS OF THE FAT PHASE MASS DISTRIBUTION AND RELAXATION SPECTRA OF DAIRY PRODUCTS

    Directory of Open Access Journals (Sweden)

    V. E. Merzlikin

    2015-01-01

    Full Text Available The article deals with the search for optimal parameter estimation of the parameters of the process of homogenization of dairy products. Provides a theoretical basis for relationship of the relaxation time of the fat globules and attenuation coefficient of ultrasonic oscillations in dairy products. Suggested from the measured acoustic properties of milk to make the calculations of the mass distribution of fat globules. Studies on the proof of this hypothesis. Morphological analysis procedure carried out for homogenized milk samples at different pressures, as well as homogenized. As a result of research obtained distribution histogram of fat globules in dependence on the homogenization pressure. Also performed acoustic studies to obtain the frequency characteristics of loss modulus as a function of homogenization pressure. For further research the choice of method for approximating dependences is obtained using statistical moments of distributions. The parameters for the approximation of the distribution of fat globules and loss modulus versus pressure homogenization were obtained. Was carried out to test the hypothesis on the relationship parameters of approximation of the distribution of the fat globules and loss modulus as a function of pressure homogenization. Correlation analysis showed a clear dependence of the first and second statistical moment distributions of the pressure homogenization. The obtain ed dependence is consistent with the physical meaning of the first two moments of a statistical distribution. Correlation analysis was carried out according to the statistical moments of the distribution of the fat globules from moments of loss modulus. It is concluded that the possibility of ultrasonic testing the degree of homogenization and mass distribution of the fat globules of milk products.

  5. Studies on the antidandruff activity of the essential oil of coleus amboinicus and eucalyptus globulus

    Directory of Open Access Journals (Sweden)

    P.Selvakumar

    2012-10-01

    Full Text Available Objective: To determine the effect of the essential oil of Coleus amboinicus and Eucalyptus globules as potential antidandruff agent. Methods: Fresh leaves of Coleus amboinicus and Eucalyptus globules were collected from the Horticultural Research Station, Yercaud, Salem, Tamil Nadu, India. The collected leaves were washed thoroughly and shade dried for 7-10 days. The essential oils from both the dried plant leaves were obtained by hydro distillation procedure. The chemical compositions of hydro distilled essential oils were analyzed by Gas Chromatography-Mass spectrometry (GC-MS. The pure essential oils and the essential oils diluted with coconut oil of the two plants were used to check antidandruff activity against the dandruff causing fungus Malassezia furfur by agar well diffusion assay. Results: The average yield of essential oil from Coleus amboinicus (0.89% and Eucalyptus globules (0.77%. The results of GC-MS revealed that the presence of eight compounds from Coleus amboinicus essential oil and five constituents from Eucalyptus globules representing 90.45% and 96.32% of the total oil respectively. The major component was identified as Thymol (phenolic rich compocnd (41.3% in Coleus amboinicus and in Eucalyptus globules the major constituents was 1-8, Cineol (91.61%. In the antidandruff activity the broad range of inhibitory zone was observed in Eucalyptus globules (37mm oil compare to Coleus amboinicus (31mm. Ketaconazole based shampoo used as a standard. Conclusion: This study would direct to the establishment of a natural compound from Coleus amboinicus and Eucalyptus globules as an antidandruff agent which can be used for the production of potential antifungal drug and novel pharmaceutical and cosmeceutical leads.

  6. Globular bodies: a primary cause of the opacity in senile and diabetic posterior cortical subcapsular cataracts?

    Science.gov (United States)

    Creighton, M O; Trevithick, J R; Mousa, G Y; Percy, D H; McKinna, A J; Dyson, C; Maisel, H; Bradley, R

    1978-07-01

    We examined 9 cataracts from maturity onset diabetics and 4 senile posterior subcapsular cataracts by scanning electron microscopy, transmission electron microscopy, immunofluorescence for crystallin proteins and actin, histochemical methods and x-ray diffraction. The cataractous regions contained spherical globules up to 20 mu in diameter, often in a fibrous matrix. Some were extracellular Morgagnian globules, apparently formed by blebbing from the cell surface; others appeared to have been formed intracellularly. The area of globular degeneration was usually 300 mu deep, but had deeper fusiform extensions. Morphological changes in the cell cytoplasm varied according to their depth in the cataract. Electron microscopy showed intracellular and extracellular globules, many of them were bounded by lipid bilayer membranes. Immunofluorescent staining showed that all the globules contained gamma-crystallin; some contained alpha- and beta-crystallins and actin. All the globules contained higher concentrations of cysteine or cystine than the surrounding lens tissue but they did not react to stains for carbohydrate or calcium. X-ray diffraction studies showed that crystalline calcium salts were absent. Globules and cavities averaged 45% of the total area in cross section. Assuming an area of cataract to be 300 micron thick and that globules 1 mu in diameter scattered, while 2--20 mu in diameter reflected light, we calculated that light passing through such a thickness would be reduced by 65%. Thus the globules could account for most of the opacity of the cataractous area. Presumably the fibrous degeneration of the cells causes enough light scattering to account for the remainder of the reduction. Cataract patients complain of decreased visual acuity, a golden halo around objects, and difficulties when driving while facing oncoming traffic at night. These probably result from light scattering. In our previous experiments, globular bodies containing gamma-crystallin were

  7. Collapse transitions in thermosensitive multi-block copolymers: A Monte Carlo study

    International Nuclear Information System (INIS)

    Rissanou, Anastassia N.; Tzeli, Despoina S.; Anastasiadis, Spiros H.; Bitsanis, Ioannis A.

    2014-01-01

    Monte Carlo simulations are performed on a simple cubic lattice to investigate the behavior of a single linear multiblock copolymer chain of various lengths N. The chain of type (A n B n ) m consists of alternating A and B blocks, where A are solvophilic and B are solvophobic and N = 2nm. The conformations are classified in five cases of globule formation by the solvophobic blocks of the chain. The dependence of globule characteristics on the molecular weight and on the number of blocks, which participate in their formation, is examined. The focus is on relative high molecular weight blocks (i.e., N in the range of 500–5000 units) and very differing energetic conditions for the two blocks (very good—almost athermal solvent for A and bad solvent for B). A rich phase behavior is observed as a result of the alternating architecture of the multiblock copolymer chain. We trust that thermodynamic equilibrium has been reached for chains of N up to 2000 units; however, for longer chains kinetic entrapments are observed. The comparison among equivalent globules consisting of different number of B-blocks shows that the more the solvophobic blocks constituting the globule the bigger its radius of gyration and the looser its structure. Comparisons between globules formed by the solvophobic blocks of the multiblock copolymer chain and their homopolymer analogs highlight the important role of the solvophilic A-blocks

  8. Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion.

    Science.gov (United States)

    Ando, Hideya; Niki, Yoko; Ito, Masaaki; Akiyama, Kaoru; Matsui, Mary S; Yarosh, Daniel B; Ichihashi, Masamitsu

    2012-04-01

    Recent studies have described the role of shedding vesicles as physiological conveyers of intracellular components between neighboring cells. Here we report that melanosomes are one example of shedding vesicle cargo, but are processed by a previously unreported mechanism. Pigment globules were observed to be connected to the filopodia of melanocyte dendrites, which have previously been shown to be conduits for melanosomes. Pigment globules containing multiple melanosomes were released from various areas of the dendrites of normal human melanocytes derived from darkly pigmented skin. The globules were then captured by the microvilli of normal human keratinocytes, also derived from darkly pigmented skin, which incorporated them in a protease-activated receptor-2 (PAR-2)-dependent manner. After the pigment globules were ingested by the keratinocytes, the membrane that surrounded each melanosome cluster was gradually degraded, and the individual melanosomes then spread into the cytosol and were distributed primarily in the perinuclear area of each keratinocyte. These results suggest a melanosome transfer pathway wherein melanosomes are transferred from melanocytes to keratinocytes via the shedding vesicle system. This packaging system generates pigment globules containing multiple melanosomes in a unique manner.

  9. Collapse transitions in thermosensitive multi-block copolymers: A Monte Carlo study

    Science.gov (United States)

    Rissanou, Anastassia N.; Tzeli, Despoina S.; Anastasiadis, Spiros H.; Bitsanis, Ioannis A.

    2014-05-01

    Monte Carlo simulations are performed on a simple cubic lattice to investigate the behavior of a single linear multiblock copolymer chain of various lengths N. The chain of type (AnBn)m consists of alternating A and B blocks, where A are solvophilic and B are solvophobic and N = 2nm. The conformations are classified in five cases of globule formation by the solvophobic blocks of the chain. The dependence of globule characteristics on the molecular weight and on the number of blocks, which participate in their formation, is examined. The focus is on relative high molecular weight blocks (i.e., N in the range of 500-5000 units) and very differing energetic conditions for the two blocks (very good—almost athermal solvent for A and bad solvent for B). A rich phase behavior is observed as a result of the alternating architecture of the multiblock copolymer chain. We trust that thermodynamic equilibrium has been reached for chains of N up to 2000 units; however, for longer chains kinetic entrapments are observed. The comparison among equivalent globules consisting of different number of B-blocks shows that the more the solvophobic blocks constituting the globule the bigger its radius of gyration and the looser its structure. Comparisons between globules formed by the solvophobic blocks of the multiblock copolymer chain and their homopolymer analogs highlight the important role of the solvophilic A-blocks.

  10. Collapse transitions in thermosensitive multi-block copolymers: A Monte Carlo study

    Energy Technology Data Exchange (ETDEWEB)

    Rissanou, Anastassia N., E-mail: rissanou@tem.uoc.gr [Department of Mathematics and Applied Mathematics, University of Crete, GR-71003 Heraklion Crete, Greece and Archimedes Center for Analysis, Modeling and Computation, University of Crete, P.O. Box 2208, GR-71003 Heraklion Crete (Greece); Tzeli, Despoina S. [Department of Materials Science and Technology, University of Crete, GR-71003 Heraklion Crete (Greece); Anastasiadis, Spiros H. [Department of Chemistry, University of Crete, P.O. Box 2208, 710 03 Heraklion Crete (Greece); Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas, GR-71110 Heraklion Crete (Greece); Bitsanis, Ioannis A. [Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas, GR-71110 Heraklion Crete (Greece)

    2014-05-28

    Monte Carlo simulations are performed on a simple cubic lattice to investigate the behavior of a single linear multiblock copolymer chain of various lengths N. The chain of type (A{sub n}B{sub n}){sub m} consists of alternating A and B blocks, where A are solvophilic and B are solvophobic and N = 2nm. The conformations are classified in five cases of globule formation by the solvophobic blocks of the chain. The dependence of globule characteristics on the molecular weight and on the number of blocks, which participate in their formation, is examined. The focus is on relative high molecular weight blocks (i.e., N in the range of 500–5000 units) and very differing energetic conditions for the two blocks (very good—almost athermal solvent for A and bad solvent for B). A rich phase behavior is observed as a result of the alternating architecture of the multiblock copolymer chain. We trust that thermodynamic equilibrium has been reached for chains of N up to 2000 units; however, for longer chains kinetic entrapments are observed. The comparison among equivalent globules consisting of different number of B-blocks shows that the more the solvophobic blocks constituting the globule the bigger its radius of gyration and the looser its structure. Comparisons between globules formed by the solvophobic blocks of the multiblock copolymer chain and their homopolymer analogs highlight the important role of the solvophilic A-blocks.

  11. Strengthening Science-based Environmental Policy Development in ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Meanwhile, companies are rushing to this resource-rich country. ... encourage and assist in the creation of a business council on environment and development ... L'importance des services de garde d'enfants pour améliorer les possibilités ...

  12. Les services de santé en Afrique en voie d'entrer dans l'ère ...

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    7 oct. 2010 ... ... de nouvelles possibilités d'application de leurs compétences dans un ... d'un téléphone mobile connecté à un serveur peuvent non seulement se ... where smoking has been rated the second highest health concern, aft.

  13. The Electric Sheep Nightmare. J. G. Ballard and the Perverse Use of Technology

    Directory of Open Access Journals (Sweden)

    Andrea Chiurato

    2014-12-01

    Unendo i due aspetti si cercherà infine di dimostrare come la costante riflessione sul cambiamento tecnologico abbia portato Ballard non tanto a un semplice aggiornamento dei motivi e delle tematiche tradizionali della science fiction, quanto piuttosto ad una più generale reinterpretazione dei limiti e delle possibilità conoscitive del genere stesso.

  14. Fondements pour l'innovation | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    appels d'offres concurrentiels. Si vous souhaitez en savoir plus sur nos priorités de financement de recherche, des précisions sur l'admissibilité et l'orientation thématique des possibilités de financement seront affichées sur la page financement ...

  15. Ouverture du cyberespace - la génération numérique, la démocratie ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En Amérique latine, les groupes criminels transnationaux et les narcotrafiquants utilisent souvent le cyberespace, faisant ainsi peser des menaces sur l'État. Dans cette région, les deux tiers des internautes ont moins de 25 ans, et 84 % des internautes utilisent Facebook. Les possibilités de fraude et de cybercriminalité se ...

  16. Publications | Page 2 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Documentaire sur des solutions locales qui permettent d'offrir plus de possibilités d'emploi aux femmes au Rwanda. Quand Nyirangaruye Dancilla a perdu son mari, elle s'est tournée vers la production de vin de banane pour ne pas se retrouver sans ressources. Aujourd'hui, les revenus de cette entreprise permettent à ...

  17. Documentary shows how local solutions can expand rural women's ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 nov. 2017 ... Documentaire sur des solutions locales qui permettent d'offrir plus de possibilités d'emploi aux femmes au Rwanda. Quand Nyirangaruye Dancilla a perdu son mari, elle s'est tournée vers la production de vin de banane pour ne pas se retrouver sans ressources. Voir davantageDocumentaire sur des ...

  18. Publications | Page 6 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Documentaire sur des solutions locales qui permettent d'offrir plus de possibilités d'emploi aux femmes au Rwanda. Quand Nyirangaruye Dancilla a perdu son mari, elle s'est tournée vers la production de vin de banane pour ne pas se retrouver sans ressources. Aujourd'hui, les revenus de cette entreprise permettent à ...

  19. Tanzanie | Page 2 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Read more about Documentaire sur des solutions locales qui permettent d'offrir plus de possibilités d'emploi aux femmes au Rwanda. Langue French. When Nyirangaruye Dancilla was widowed she turned to producing banana wine to avoid destitution. Now income from this business enables this Rwandan farmer to save ...

  20. Cap sur l'Ouest : les Prairies canadiennes, élément essentiel de la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    1 mai 2014 ... Doté de 124 millions de dollars par le gouvernement du Canada, ce Fonds donne la possibilité à des chercheurs du Canada et de pays en développement de conjuguer leurs compétences afin de favoriser les innovations en agriculture et en nutrition, en particulier celles qui profitent aux petits exploitants ...

  1. Far East Asia | Page 114 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Far East Asia. Extrême-Orient. Read more about Femmes et gouvernance locale - exploration de nouvelles possibilités. Language French. Read more about Integrated Approach to Address Food and Nutrition Security in the Philippines. Language English. Read more about Incidence des prix et des taxes sur la ...

  2. un_focus - Les pauvres et l'information : Lutter contre la pauvreté à l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    25 nov. 2013 ... Fast-tracking the digital revolution: Broadband for Latin America and the Caribbean ... Leveraging the budget telecom network business model to bring broadband to ... Partager les possibilités d'innovation dans le domaine de ...

  3. Far East Asia | Page 72 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Far East Asia. Extrême-Orient. Read more about Institutionnalisation et élargissement de la protection sociale en Asie. Language French. Read more about TIC et microentreprises en milieu urbain : optimisation des possibilités de développement économique. Language French. Read more about ICTs and Urban Micro ...

  4. New Compensation Mechanisms for Creativity and Inclusion

    International Development Research Centre (IDRC) Digital Library (Canada)

    Il tient aussi des tables rondes sur les politiques et promeut l'étude et l'excellence ...... opérationnel et stratégique et d'examiner les possibilités de collaboration. ...... le ministère a adopté une politique de recrutement régionalisé de certaines ...

  5. Marketing Information Products and Services: A Primer for Librarians ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Library and information sciences are experiencing a period of radical change. Today ... the customer base and fulfilling customer requirements and expectations? ... L'importance des services de garde d'enfants pour améliorer les possibilités ...

  6. Intégration de la dimension genre à la lutte contre la pauvreté et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... le marché du travail, et en partie à cause des nouvelles possibilités découlant de la mondialisation. ... New funding opportunity for gender equality and climate change ... IDRC invests in research and knowledge to empower women in India.

  7. Recherche sur l'adaptation aux changements climatiques

    International Development Research Centre (IDRC) Digital Library (Canada)

    Corey Piccioni

    consortiums travaillent dans des zones vulnérables aux changements climatiques en Afrique et en Asie, notamment dans les bassins hydrographiques alimentés .... Le projet de recherche Pathways to Resilience in Semi-Arid Economies (PRISE) vise à réduire les risques et à opti- miser les possibilités de développement ...

  8. Research and International Trade Policy Negotiations: Knowledge ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    7 oct. 2009 ... The editor. Mercedes Botto is Senior Researcher at FLACSO, the Facultad Latinoamericana de Ciencias Sociales, in Buenos Aires, Argentina. Contenus connexes. Politiques d'innovation régionales dans la zone Mercosur - obstacles et possibilités. Cette subvention soutiendra l'exécution d'une étude des ...

  9. Employment and Growth | Page 14 | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Read more about Pathways for shared prosperity: Understanding the links between women's economic empowerment and growth (GrOW). Language English ... Read more about Incidences des programmes d'acquisition de compétences sur les possibilités économiques des femmes au Pakistan. Language French.

  10. Sustainable Development at Risk: Ignoring the Past | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The analysis begins with the Atlantic Charter, the creation of the United Nations, its family of agencies, and the international development banks. It reviews recommendations from ... L'importance des services de garde d'enfants pour améliorer les possibilités économiques des femmes. Le 11 août 2017, des chercheurs et ...

  11. : tous les projets | Page 134 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet vise à inspirer des politiques qui aideront des groupes marginalisés en Afrique, tels que les femmes et les pauvres, à tirer avantage des possibilités sociales et économiques qu'offre l'Internet à large bande. Sujet: TELECOMMUNICATIONS. Région: North of Sahara, South of Sahara, Kenya, Nigeria, South Africa.

  12. Nouvelles fonctionnalités (cartographiques offertes sur le web

    Directory of Open Access Journals (Sweden)

    Laurent Jégou

    2014-04-01

    Full Text Available Les possibilités offertes par les technologies Internet libres dans le domaine du graphisme, et plus spécifiquement de l’infographie et de la cartographie, semblent avoir stagné après un premier stade de développement au début des années 2000.

  13. Extraction of Mo, W and Tc with polyurethane foam and with cyclic polyether from SCN-/HC1 medium

    International Nuclear Information System (INIS)

    Caletka, R.; Hausbeck, R.; Krivan, V.

    1986-01-01

    The extraction of molybdenum, tungsten and technetium by polyether-based polyurethane foam and by a cyclic polyether from aqueous thiocyanate solutions is described. The influence of the reductants stannous chloride and ascorbic acid has also been studied. The possibilites of the polyurethane foam for preconcentration and determination of molybdenum are discussed. (author)

  14. Kenya | Page 29 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Read more about Transferring the Malaria Epidemic Prediction Model to Users in East Africa. Language English. Read more about East African GEOHealth hub for preventing environmental and occupational health risks. Language English. Read more about Accroître les possibilités économiques pour les jeunes dans les ...

  15. Représentation des flux en C.A.O.

    Directory of Open Access Journals (Sweden)

    Élisabeth RENAULT

    1987-09-01

    Full Text Available La technologie offerte par l'informatique graphique permet un regard neuf sur un domaine particulier de la cartographie : la représentation des flux. Plusieurs exemples montrent quelques-unes des possibilités envisagées dans la conception d'un logiciel spécialisé.

  16. Results-based financing for equitable access to maternal and child ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The project will also look at the impact of results-based financing on health providers' motivation and teamwork, local leadership, community management committees of health facilities, access to and use of health ... L'importance des services de garde d'enfants pour améliorer les possibilités économiques des femmes.

  17. work pdf

    African Journals Online (AJOL)

    MIN

    En bref, l'immunohistochimie permet au pathologiste préciser son diagnostic au maximum, ce qui à son tour, donne au clinicien la possibilité de choisir le traitement ... Given that immunohistochemistry is costly, it is therefore essential to make the best choice amongst the numerous available antibody tests, whose diagnostic ...

  18. Qu'est-ce qui détermine l'accès aux TIC aux Philippines ? | IDRC ...

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    8 févr. 2011 ... Le guide dépasse cependant l'anecdote et les conseils pour traiter de la question ... par la population à ces instruments et ses capacités à les utiliser ». .... sont les possibilités qu'elles servent d'outils pour le développement.

  19. Rapport financier trimestriel

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sophie Comeau

    30 juin 2011 ... de précisions sur l'incidence de la transition aux IFRS de même que le rapprochement des .... Il y a eu amélioration notable des possibilités de placement et des ..... Les gains et pertes de change sont pris en compte dans.

  20. Some remarks on perturbation in flame photometry; Quelques remarques sur les perturbations dans la photometrie de flamme

    Energy Technology Data Exchange (ETDEWEB)

    Malinowski, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    After classifying the various types of perturbations, the author attempts to explain their causes. He then gives examples of possibilities of suppressing them. (author) [French] Ayant classe les divers types de perturbations en categories, l'auteur essaie d'expliquer les causes de ces perturbations. Il donne ensuite des exemples de possibilites de les supprimer. (auteur)

  1. Examen de la visualisation de données (version abrégée)

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    3). » [TRADUCTION LIBRE]. Le présent examen évalue les possibilités qu'offre ... 3 sations sont bien conçues, elles peuvent non seu- lement accroître la ...... Now You See It: Simple Visu- ... Information is Beautiful, ... “Choosing Colors for Da-.

  2. Taxation and Gender Equity: A Comparative Analysis of Direct and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    10 juin 2010 ... This groundbreaking volume examines the gender dimensions of tax systems in seven developing and one developed country and is the first systematic treatment of its kind. ... L'importance des services de garde d'enfants pour améliorer les possibilités économiques des femmes. Le 11 août 2017, des ...

  3. Une proposition de nouveau cartogramme

    Directory of Open Access Journals (Sweden)

    Raymond Badel

    1990-05-01

    Full Text Available Le cartogramme proposé est une technique de recherche-exploration rapide grâce aux possibilités offertes par le micro-ordinateur et sa diffusion. La propriété foncière en vallée d'Aure lui sert de support.

  4. Building Research Excellence in Wildlife and Human Health in Sri ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Known for its dense human population, diverse wild animal species, and large ... It will offer best practice models for programming and governance of the Wildlife ... Partager les possibilités d'innovation dans le domaine de l'adaptation aux ...

  5. La santé en milieu urbain | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    13 déc. 2010 ... Les villes attirent des millions de personnes en quête d'une vie meilleure. ... possibilités, mais exposent aussi les habitants à de nouveaux dangers. .... ÉTUDE DE CAS — Népal : Améliorer l'hygiène et la santé à Katmandou.

  6. Résultats de recherche | Page 15 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La croissance exponentielle de la capacité de stockage des données conjuguée à l'essor des médias sociaux et à la multiplication des applications commerciales en ligne offrent aux entreprises et aux gouvernements la possibilité d'interce. Projet ...

  7. HealthBridge : Information and Communication Technologies for ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project aims to improve data management from the point where data are first collected, through entry, cleaning and archiving, thereby increasing the efficiency and accuracy of data collection and analysis. The key ... L'importance des services de garde d'enfants pour améliorer les possibilités économiques des femmes.

  8. Examples on cold forged aluminium components in automotive industry

    DEFF Research Database (Denmark)

    Bay, Niels; Kolsgaard, A.

    2000-01-01

    The present paper describes the possibilites of applying cold forging for manufacturing of light weight components in aluminium. A short description of the basic cold forming processes forms the basis for describing the great variety in design of cold forged components. Examples are mainly taken ...... from automotive industry but in a few cases also from other industrial sectors to show the possibilities....

  9. Plans d'action sur l'adaptation aux changements climatiques pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les plans seront mis à la disposition du Natural Resources Defense Council et de l'Indian Institute of Public Health pour permettre d'analyser la possibilité de les appliquer à d'autres villes en Inde. Project ID. 108453. Project status. Active. Duration. 36 months. IDRC Officer. Melanie Robertson. Total funding. CA$ 1,001,800 ...

  10. Performances and potential of a productive urban green infrastructure

    Directory of Open Access Journals (Sweden)

    Paola Gallo

    2016-06-01

    Full Text Available Negli ultimi anni si sta diffondendo anche nelle grandi città Europee, un fenomeno complesso che coinvolge la disciplina dell’architettura: l’agricoltura urbana, ovvero la pratica della coltivazione, di prodotti orticoli “nella città, per la città”. La produzione agricola, trasportata in un contesto urbano, diviene ad oggi una strategia concreta per la riqualificazione delle città grazie a: l’innesco di una rete di attività sociali, ricreative e commerciali, la possibilità di rifunzionalizzazione di spazi privati e pubblici (soprattutto quelli inutilizzati, di creazione di verde condiviso, la possibilità di integrazione con l’ambiente costruito, la valorizzazione di stili di vita sostenibili, l’occasione di educazione e collante sociale, il potenziamento e nuove possibilità all’infrastruttura verde (produttiva. Questo fenomeno necessita dunque di essere studiato per comprenderne e definirne le potenzialità, poiché l’architetto è chiamato a concepire spazi per rispondere a nuove esigenze ed a progettare soluzioni innovative alle diverse scale. Sulla base di tale consapevolezza è stata condotta una ricerca sul tema della riqualificazione della città in chiave sostenibile e sulle nuove tecnologie da mettere in atto finalizzata ad analizzare ed individuare le possibilità dell’agricoltura urbana come strategia innovativa per il potenziamento delle reti verdi nella città, definendo lo spettro di possibilità che questa offre al progettista, e di rimando alla pubblica amministrazione, per una nuova interpretazione della funzione sia dello spazio aperto che del patrimonio costruito.

  11. Luminescence response of synthetic opal under femtosecond laser pumping

    International Nuclear Information System (INIS)

    Vasnetsov, M.V.; Bazhenov, V.Yu.; Dmitruk, I.N.; Kudryavtseva, A.D.; Tcherniega, N.V.

    2015-01-01

    Synthetic opal is an artificial photonic metamaterial composed from spherical globules of amorphous silica (SiO 2 ) about 300 nm in diameter. We report, for the first time to our knowledge, the origin of a narrow luminescence spectral peak (4 nm HWHM) and optical second and third harmonic generation in synthetic opal samples under femtosecond laser excitation (800 nm) at liquid-nitrogen temperature. Stimulated-emission effects are discussed related to the possibility of nanocavity lasing at the condition of the first Mie resonance in a dielectric sphere. - Highlights: • Second harmonic generation in a synthetic opal (amorphous material composed from spherical SiO 2 globules) was observed. • Narrow luminescence peak which we assign to a Mie resonance in a globule was detected at liquid-nitrogen temperature

  12. Wound Status Early Outcome Sensor and 3D Construct Development

    Science.gov (United States)

    2015-03-01

    1.35 Fyn  94 83 0.11 0.04 0.74 0.99 Milk   Fat  Globule Membrane  Protein 1.35 Milk   Fat  Globule Membrane  Protein 1413 1240 0.02 0.03 11.06 14.94 PGP9.5...reproducible in biological replicates, which indicates the possibility of random bias for certain proteins with iTRAQ channel specificity. Raw spectrum...public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Early identification of the specific proteins , which indicate delayed

  13. Isotopic Anomalies in Organic Nanoglobules from Comet 81P/Wild 2: Comparison to Murchison Nanoglobules and Isotopic Anomalies Induced in Terrestrial Organics by Electron Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    De Gregorio, B.; Stroud, R; Nittler, L; Alexander, C; Kilcoyne, A; Zega, T

    2010-01-01

    Nanoglobules are a form of organic matter found in interplanetary dust particles and primitive meteorites and are commonly associated with {sup 15}N and D isotopic anomalies that are suggestive of interstellar processes. We report the discovery of two isotopically-anomalous organic globules from the Stardust collection of particles from Comet 81P/Wild 2 and compare them with nanoglobules from the Murchison CM2 meteorite. One globule from Stardust Cometary Track 80 contains highly aromatic organic matter and a large {sup 15}N anomaly ({delta}{sup 15}N = 1120{per_thousand}). Associated, non-globular, organic matter from this track is less enriched in {sup 15}N and contains a mixture of aromatic and oxidized carbon similar to bulk insoluble organic material (IOM) from primitive meteorites. The second globule, from Cometary Track 2, contains non-aromatic organic matter with abundant nitrile ({single_bond}C{triple_bond}N) and carboxyl ({single_bond}COOH) functional groups. It is significantly enriched in D ({delta}D = 1000{per_thousand}) but has a terrestrial {sup 15}N/{sup 14}N ratio. Experiments indicate that similar D enrichments, unaccompanied by {sup 15}N fractionation, can be reproduced in the laboratory by electron irradiation of epoxy or cyanoacrylate. Thus, a terrestrial origin for this globule cannot be ruled out, and, conversely, exposure to high-energy electron irradiation in space may be an important factor in producing D anomalies in organic materials. For comparison, we report two Murchison globules: one with a large {sup 15}N enrichment and highly aromatic chemistry analogous to the Track 80 globule and the other only moderately enriched in {sup 15}N with IOM-like chemistry. The observation of organic globules in Comet 81P/Wild 2 indicates that comets likely sampled the same reservoirs of organic matter as did the chondrite parent bodies. The observed isotopic anomalies in the globules are most likely preserved signatures of low temperature (<10 K

  14. Isotopic anomalies in organic nanoglobules from Comet 81P/Wild 2: Comparison to Murchison nanoglobules and isotopic anomalies induced in terrestrial organics by electron irradiation

    Science.gov (United States)

    De Gregorio, Bradley T.; Stroud, Rhonda M.; Nittler, Larry R.; Alexander, Conel M. O.'D.; Kilcoyne, A. L. David; Zega, Thomas J.

    2010-08-01

    Nanoglobules are a form of organic matter found in interplanetary dust particles and primitive meteorites and are commonly associated with 15N and D isotopic anomalies that are suggestive of interstellar processes. We report the discovery of two isotopically-anomalous organic globules from the Stardust collection of particles from Comet 81P/Wild 2 and compare them with nanoglobules from the Murchison CM2 meteorite. One globule from Stardust Cometary Track 80 contains highly aromatic organic matter and a large 15N anomaly (δ 15N = 1120‰). Associated, non-globular, organic matter from this track is less enriched in 15N and contains a mixture of aromatic and oxidized carbon similar to bulk insoluble organic material (IOM) from primitive meteorites. The second globule, from Cometary Track 2, contains non-aromatic organic matter with abundant nitrile ( sbnd C tbnd N) and carboxyl ( sbnd COOH) functional groups. It is significantly enriched in D (δD = 1000‰) but has a terrestrial 15N/ 14N ratio. Experiments indicate that similar D enrichments, unaccompanied by 15N fractionation, can be reproduced in the laboratory by electron irradiation of epoxy or cyanoacrylate. Thus, a terrestrial origin for this globule cannot be ruled out, and, conversely, exposure to high-energy electron irradiation in space may be an important factor in producing D anomalies in organic materials. For comparison, we report two Murchison globules: one with a large 15N enrichment and highly aromatic chemistry analogous to the Track 80 globule and the other only moderately enriched in 15N with IOM-like chemistry. The observation of organic globules in Comet 81P/Wild 2 indicates that comets likely sampled the same reservoirs of organic matter as did the chondrite parent bodies. The observed isotopic anomalies in the globules are most likely preserved signatures of low temperature (<10 K) chemistry in the interstellar medium or perhaps the outer regions of the solar nebula. In other

  15. Semi-flexible polymer engendered aggregation/dispersion of fullerene (C60) nano-particles: An atomistic investigation

    Science.gov (United States)

    Kumar, Sunil; Pattanayek, Sudip K.

    2018-06-01

    Semi flexible polymer chain has been modeled by choosing various values of persistent length (stiffness). As the polymer chain stiffness increases, the shape of polymer chain changes from globule to extended cigar to toroid like structure during cooling from a high temperature. The aggregation of fullerene nano-particles is found to depend on the morphology of polymer chain. To maximize, the number of polymer bead-nanoparticle contacts, all nano-particle have positioned inside the polymer globule. To minimize, the energy penalty, due to bending of the polymer chain, all nano-particle have positioned on the surface of the polymer's cigar and toroid morphology.

  16. Massive photon properties in 3D photonic crystals, filled by dielectrics or metals

    International Nuclear Information System (INIS)

    Gorelik, V S

    2009-01-01

    The optical properties of 3D photonic crystals-artificial opals, consisting of monosized silica globules-have been investigated. The volume between globules was filled by various dielectrics or metals. The dispersion law of electromagnetic waves of this type of crystal has been obtained. It was shown that the sign of photonic mass in globular photonic crystals may be positive or negative for different points on dispersion curves. The value of the effective mass of photons depends on the refractive index of the substance infiltrated into the globular photonic crystal.

  17. Study of thermodynamic and structural properties of a flexible homopolymer chain using advanced Monte Carlo methods

    Directory of Open Access Journals (Sweden)

    Hammou Amine Bouziane

    2013-03-01

    Full Text Available We study the thermodynamic and structural properties of a flexible homopolymer chain using both multi canonical Monte Carlo method and Wang-Landau method. In this work, we focus on the coil-globule transition. Starting from a completely random chain, we have obtained a globule for different sizes of the chain. The implementation of these advanced Monte Carlo methods allowed us to obtain a flat histogram in energy space and calculate various thermodynamic quantities such as the density of states, the free energy and the specific heat. Structural quantities such as the radius of gyration where also calculated.

  18. Characterization of an apically derived epithelial membrane glycoprotein from bovine milk, which is expressed in capillary endothelia in diverse tissues

    OpenAIRE

    1985-01-01

    A glycoprotein (PAS IV) of apparent Mr 76,000 was purified from bovine milk-fat-globule membrane and partially characterized. PAS IV contained mannose, galactose, and sialic acid as principal sugars (approximately 5.3% total carbohydrate [wt/wt]) and existed in milk in at least four isoelectric variants. The glycoprotein appeared to be an integral membrane protein by several criteria. PAS IV was recovered in the detergent phase of Triton X-114 extracts of milk-fat-globule membrane at room tem...

  19. Interactions between Parenteral Lipid Emulsions and Container Surfaces.

    Science.gov (United States)

    Gonyon, Thomas; Tomaso, Anthony E; Kotha, Priyanka; Owen, Heather; Patel, Dipa; Carter, Phillip W; Cronin, Jim; Green, John-Bruce D

    2013-01-01

    To evaluate the relationship between changes in emulsion globule size distributions and container uptake of lipid emulsions in total nutrient admixtures. A total nutrient admixture was prepared from a commercial lipid emulsion, 20% ClinOleic®, separated into glass (borosilicate) and ethylene vinyl acetate (EVA) plastic containers, and then stored at ambient conditions for approximately 24 h. The large globule size distribution was monitored continuously for both containers, and the quantity of triglycerides associated with both containers was measured by liquid chromatography. The changes in mass of the EVA containers were also measured gravimetrically. The volume percent of globules greater than 5 microns in diameter (PFAT5) levels for an emulsion admixture in EVA containers showed a 75% reduction compared to a marginal decrease of PFAT5 when in the glass container. Extraction of the containers showed that the quantity of triglycerides associated with the EVA surfaces steadily increased with emulsion exposure time, while the glass showed a significantly lower triglyceride content compared to the EVA. Gravimetric measurements confirmed that the EVA containers gained significant mass during exposure to the emulsion admixture. A time-dependent decrease in PFAT5 values for an emulsion admixture was associated with container triglyceride absorption where EVA containers had a greater uptake than glass containers. The larger globules appear to absorb preferentially, and the admixture globule size distribution fraction represented by PFAT5 accounts for 15-20% of the total triglyceride adsorption to the container. The goal of this work is to evaluate how emulsions in total nutrition admixtures are affected by the containers within which they are stored. Specifically, the study examines how the emulsion globule size distribution in different containers is related to adsorption or absorption of the lipids onto or into the container. The admixtures were prepared from a

  20. Optical polarization studies of Herbig-Haro objects: Pt. 5

    International Nuclear Information System (INIS)

    Scarrott, S.M.; Warren-Smith, R.F.

    1988-01-01

    Optical linear polarization maps are presented for the HH46/47 nebulosities in the ESO210-6A dark globule. HH46 is part of an optical bipolar nebula illuminated by an obscured source - HH46IRS. The polarization pattern in the immediate neighbourhood of the source suggests the presence of circumstellar disc oriented in such a manner that the well-collimated outflows propagate along the major axis of the disc before creating the Herbig-Haro knots HH47A/B/C on the periphery of the globule. (author)

  1. Optical polarization studies of Herbig-Haro objects. Pt. 7

    International Nuclear Information System (INIS)

    Scarrott, S.M.; Gledhill, T.M.; Rolph, C.D.

    1990-01-01

    A small patch of optical nebulosity in the cometary globule CG30 is an amorphous reflection nebula containing a Herbig-Haro knot. The exciting and illuminating star, which we identify with the IR source IRAS 08076-3356/CG30IRS4, is deeply embedded in the globule and is not seen directly at optical wavelengths. Structure in the polarization data suggests that the optical nebula is formed by the illumination of the walls of a cavity excavated in the cloud during outflow activity from the embedded source. (author)

  2. Pre-fermentation addition of grape tannin increases the varietal thiols content in wine.

    Science.gov (United States)

    Larcher, Roberto; Tonidandel, Loris; Román Villegas, Tomás; Nardin, Tiziana; Fedrizzi, Bruno; Nicolini, Giorgio

    2015-01-01

    The recent finding that grape tannin may contain significant amount of S-glutathionylated (GSH-3MH) and S-cysteinylated (Cys-3MH) precursors of the varietal thiols 3-mercapto-1-hexanol and 3-mercaptohexyl acetate, characteristic of Sauvignon blanc wines, offers new opportunities for enhancing the tropical aroma in fermented beverages. In this study this new hypothesis was investigated: Müller Thurgau (17 samples) and Sauvignon blanc (15 samples) grapes were fermented with and without addition of a selected grape tannin. As expected, the tannin-added juices were higher in precursors, and they produced wines with increased free thiols. Preliminary informal sensory tests confirmed that in particular the Sauvignon wines produced with the tannin addition were often richer with increased "fruity/green" notes than the corresponding reference wines. This outcome confirms that grape tannin addition prior to fermentation can fortify the level of these compounds. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Interfon

    CERN Multimedia

    Interfon

    2010-01-01

    Dès maintenant préparons les Fêtes … N’oubliez pas que notre Coopérative, comme chaque année, vous offre l’occasion de vous approvisionner en volailles de Bresse. Passez vos commandes dès maintenant : Chapons, dindes, poulets, poulardes, pintades, canards et canettes.   Il est impératif de remplir un Bon de commande. Les commandes seront enregistrées jusqu’au 15 décembre et seront livrées les 22 ou 23 décembre (l’information vous sera communiquée individuellement ultérieurement). La cave Interfon vous propose ses champagnes disponibles dès maintenant : Brut – Demi-sec – Rosé – Millésimé - Prestige – Blancs de blanc. N’attendez pas le dernier moment les retardataires pourraient ne pas êtr...

  4. First experience with particle-in-cell plasma physics code on ARM-based HPC systems

    Science.gov (United States)

    Sáez, Xavier; Soba, Alejandro; Sánchez, Edilberto; Mantsinen, Mervi; Mateo, Sergi; Cela, José M.; Castejón, Francisco

    2015-09-01

    In this work, we will explore the feasibility of porting a Particle-in-cell code (EUTERPE) to an ARM multi-core platform from the Mont-Blanc project. The used prototype is based on a system-on-chip Samsung Exynos 5 with an integrated GPU. It is the first prototype that could be used for High-Performance Computing (HPC), since it supports double precision and parallel programming languages.

  5. Biodiversity of wine grapes: less than we thought

    Directory of Open Access Journals (Sweden)

    Pinder RM

    2011-07-01

    Full Text Available Roger M PinderInternational Journal of Wine Research, York, UKThe Editor of the International Journal of Wine Research has had a long-standing interest in the genetics of wine grape varieties. Two publications, in particular, piqued the interest from both the scientific and consumer point of view. Cabernet Sauvignon is the offspring of a chance cross-pollination of Sauvignon Blanc and Cabernet Franc in western France several centuries ago.

  6. Evaluation of the Stress Resilience Training System

    Science.gov (United States)

    2014-10-30

    burnout were assessed before and after an eight week training period. Significant improvement in overall stress was observed; however, there were no...significantly based on location, role, and mission. Regardless of cause, the accumulation of stress over time can lead to burnout (Taris, LeBlanc, Schaufeli...such as hospital floor nurses (28%). 5.4 Post-Traumatic Stress The PTSD Checklist, military version (PCL-M) results indicated that 1 participant (4

  7. Cost-Effectiveness of Flight Simulators for Military Training. Volume 1. Use and Effectiveness of Flight Simulators

    Science.gov (United States)

    1977-08-01

    Training Division DCS for Personnel LCOL Ralph H. Lauder Aviation Systems Division DCS, RDA CAPT James LeBlanc Aviation Manpower and Training...Since. a commercial flight brings in money to the airlines, their pilots are encouraged to fly up to the limit supported by the market. A military...by 17 percent in FY 1981. Thus, while flight simulators may save money by reducing flying hours, it is also necessary to demonstrate that they are

  8. Fission track dating of zircon: a multichronometer

    International Nuclear Information System (INIS)

    Carpena, J.

    1992-01-01

    Scattering in Fission Track ages of zircons of a single rock is possible when they present morphological and geochemical variations, if the greatest care is not taken in the choice of the etching conditions and the counting of tracks. The Fission Track study of two heterogeneous populations of zircons from the Mont Blanc granite and from the Gran Paradiso gneisses allows to show that zircon may work as a multichronometer

  9. Kodumaine multifilm õilmitseb / Mart Rummo

    Index Scriptorium Estoniae

    Rummo, Mart

    2001-01-01

    Tähistamaks eesti animafilmi 70. aastapäeva näidatakse täna Kinomajas kuut uut multifilmi : 13-osaline lamenukkfilm "Tulelaeva kulid" (režissöör Mait Laas), Ülo Pikkovi kaks joonisfilmi "Superlove" ja "Peata ratsanik", Priit Tenderi joonisfilm "Mont Blanc", Kaspar Jancise joonisfilm "Romanss" ja Janno Põldma - Heiki Ernitsa laste joonisfilmiseriaali "Lepatriinude jõulud" 5-min. trailer

  10. Proceedings of the 20th International Conference on Defects in Semiconductors Held in Berkeley, CA, USA, 26-30 July 1999

    Science.gov (United States)

    1999-07-30

    National Science Foundation through the GOALI Program, under grant number ECS-9705134. References [1] T. Ogino, M. Aoki, Jap. J. Appl. Phys. 19 (1980... pulled from molten silicon through a graphite slot for solar cell production in economical way [8]. It was observed that EFG silicon contains high...samples the closest resem- blance to our observations is found in the Au-Hj config- uration where the --/- gold acceptor level is pulled down in the

  11. Technicien en audiovisuel (h/f) | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sous la direction du chef, Gestion des installations, le titulaire gère l'équipement audiovisuel interne du CRDI, en assure la maintenance et offre du soutien ... photo et caméras vidéo numériques;; caméras de transmission de documents et numériseurs;; tableaux blancs électroniques;; systèmes d'interprétation simultanée; ...

  12. Colonization of Vitis vinifera by a Green Fluorescence Protein-Labeled, gfp-Marked Strain of Xylophilus ampelinus, the Causal Agent of Bacterial Necrosis of Grapevine

    OpenAIRE

    Grall, Sophie; Manceau, Charles

    2003-01-01

    The dynamics of Xylophilus ampelinus were studied in Vitis vinifera cv. Ugni blanc using gfp-marked bacterial strains to evaluate the relative importance of epiphytic and endophytic phases of plant colonization in disease development. Currently, bacterial necrosis of grapevine is of economic importance in vineyards in three regions in France: the Cognac, Armagnac, and Die areas. This disease is responsible for progressive destruction of vine shoots, leading to their death. We constructed gfp-...

  13. Bleeding Sap and Old Wood Are the Two Main Sources of Contamination of Merging Organs of Vine Plants by Xylophilus ampelinus, the Causal Agent of Bacterial Necrosis

    OpenAIRE

    Grall, S.; Roulland, C.; Guillaumès, J.; Manceau, C.

    2005-01-01

    The spatial distribution of vine plants contaminated by Xylophilus ampelinus, the agent responsible for bacterial necrosis, was studied over a 5-year period within two vineyards in the Cognac area. Both vineyards were planted with Vitis vinifera cv. Ugni blanc but were different in age and agronomic location. The emission of X. ampelinus in contaminated bleeding sap was observed during vine sprouting. Contaminated bleeding sap is an important source of inoculum for external contamination due ...

  14. Curves and Surfaces

    Science.gov (United States)

    1990-01-01

    joint work with Bj6rn Jawerth and Brad Lucier. Courbes et Surfaces CHAMONIX - MONT BLANC 21-27juin 1990 QUASI-Eh4TERPOIANT’S DE TYPE DE SZASZ ...t) =ect, c > 0, t e lR, et, G(IR,) = (f e C(1R: IlfiI sup ( if (t)I / (p(t), t e IR+) < +oo) L’opdrateur de Szasz -Mirakyan Sn de C,(IR+) dans G[a,b

  15. Where protons will play

    CERN Multimedia

    Holt, Jim

    2007-01-01

    "On seing the Alps for the first time, Dorothy Parket is reputed to have said, "They're beautiful, but they're dumb". Near the foot of Mont Blanc, the greatest of the alpine peaks, another sizable object is taking shape, also quite beautiful in its way, yet not at all dumb. In fact, its pristine geometries may be instrumental in revealing what have hitherto been some of nature's deepest secrets." (2 pages)

  16. Effet des Plastifiants sur la Temperature de Transition Vitreuse, Tg, du Butadiene a Terminaison Hydroxy et du Polyazoture de Glycidyle - Simulations et Experiences (Effect of the Plasticizers on the Vitreous Transition Temperature, Tg, of the Butadiene to Termination Hydroxy and the Polyazoture of Glycidyle - Simulations and Experiences)

    Science.gov (United States)

    2008-09-01

    Intentionnellement en blanc. DRDC Valcartier TR 2007-615 Executive summary The search of new energetic materials more powerful, less sensitive or more...Resume i Executive summary iii Sommaire iv Table des matieres v Liste des figures vii Listedes tableaux vii Liste des annexes vii Remerciements...plus caoutchouteux absorbe mieux les chocs , ce qui diminue les risques de detonation accidentelle. On choisira un plastifiant en tenant compte

  17. Bone Marrow-derived Mesenchymal Stem Cells (MSCs) as a Selective Delivery Vehicle for a PSA-Activated Protoxin for Advanced Prostate Cancer

    Science.gov (United States)

    2014-04-01

    L 2011 Immunosuppres- sive cells and tumour microenvironment: focus on mesenchymal stem cells and myeloid derived suppressor cells. Histology and...infusion. The lungs and tumors were harvested from each mouse, flash frozen in VWR Clear Frozen Section Oncotarget 2013; 4: 106...focus on mesenchymal stem cells and myeloid derived suppressor cells. Histol Histopathol. 2011; 26(7):941-951. 6. Dominici M, Le Blanc K, Mueller I

  18. Bacterial diversity of autotrophic enriched cultures from remote, glacial Antarctic, Alpine and Andean aerosol, snow and soil samples

    OpenAIRE

    Gonzalez-Toril , E.; Amils , R.; J. Delmas , Robert; Petit , Jean-Robert; Komarek , J.; Elster , J.

    2009-01-01

    Four different communities and one culture of autotrophic microbial assemblages were obtained by incubation of samples collected from high elevation snow in the Alps (Mt. Blanc area) and the Andes (Nevado Illimani summit, Bolivia), from Antarctic aerosol (French station Dumont d'Urville) and a maritime Antarctic soil (King George Island, South Shetlands, Uruguay Station Artigas), in a minimal mineral (oligotrophic) media. Molecular analysis of more than 200 16S rRNA gene sequences showed...

  19. Diversity of bacteria producing pigmented colonies in aerosol, snow and soil samples from remote glacial areas (Antarctica, Alps and Andes)

    OpenAIRE

    González-Toril , E.; Amils , R.; Delmas , R. J.; Petit , J.-R.; Komárek , J.; Elster , J.

    2008-01-01

    Four different communities and one culture of pigmented microbial assemblages were obtained by incubation in mineral medium of samples collected from high elevation snow in the Alps (Mt. Blanc area) and the Andes (Nevado Illimani summit, Bolivia), from Antarctic aerosol (French station Dumont d'Urville) and a maritime Antarctic soil (King George Island, South Shetlands, Uruguay Station Artigas). Molecular analysis of more than 200 16S rRNA gene sequences showed that all cultured cells be...

  20. 171-IJBCS-Article-Dr Rene Bikomo

    African Journals Online (AJOL)

    Dr Gatsing

    étaient fermés par rabattement simple du bord d'ouverture ... (Tableau 1). Le macabo blanc a le moins perdu du poids, en comparaison de la réduction de poids considérable enregistrée sur le macabo rouge pendant la même phase. ... Tableau 1: Analyse de la variance de l'effet de la variété, du stade de maturité, de la.

  1. The U.S. Department of Defenses Earned Value ManagementAnalyst Workforce

    Science.gov (United States)

    2016-01-01

    Military Departments or the Combat- ant Commands” ( Higgins and Ramsey, 2009, p. 2). 2 The Defense Contract Management Agency (DCMA) offers its workforce its...LeBlanc, Michelle Trigg, and Jonathan Higgins . The data call would not have been fielded without their expertise and support. Finally, we acknowledge...the BFM workforce. As indicated in Figure 3.1, EVM 101 (Fundamentals of EVM) is required for level I certification and EVM 201 ( Intermediate EVM) is

  2. Annales des Sciences Agronomiques: Submissions

    African Journals Online (AJOL)

    Seules les illustrations au laser seront acceptées dans le cas de celles dessinées à l'ordinateur, autrement, les illustrations seront faites sur du papier calque à l'encre de Chine. Les tableaux et figures originaux seront envoyés avec deux photocopies. Seules les photographies en noir et blanc et de bonne qualité sont ...

  3. Publications | Page 110 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    De jeunes techniciens en sarraus blancs, penchés sur leur table de travail où sont alignés une douzaine d'ordinateurs, procèdent à une batterie de tests. La scène pourrait se situer dans n'importe quelle entreprise de haute technologie... Sécurité alimentaire — Semences porteuses de menaces ou de solutions ?

  4. Secondary Aroma Compounds in Fresh Grape Marc Distillates as a Result of Variety and Corresponding Production Technology

    OpenAIRE

    Borislav Miličević; Mara Banović; Srećko Tomas; Sanja Radeka; Đordano Peršurić; Igor Lukić

    2011-01-01

    In order to investigate the composition of secondary aroma compounds of fresh grape marc distillates as a result of variety and production technology, 30 samples (6 varieties×5 samples) were analysed. White grape marc samples from Malvazija istarska, Chardonnay and Muscat Blanc were obtained as by-products in standard white wine production, while red grape marc samples from Teran and Cabernet Sauvignon were obtained after standard red wine production procedures. Marc from red grape variety Mu...

  5. Wave Structures in Thermospheric Density from Satellite Electrostatic Triaxial Accelerometer Measurements.

    Science.gov (United States)

    1987-06-04

    Testud , J. (1970) Gravity waves generated diring magnetic substorms, .1. Atmos. Terr. Phys., 32:1793. .6 t9, "-€ according to their horizontal...auroral oval during polar substorms, J. Geophys. Res., 74:5721. 7. Testud , J. P., Amayenc, P., and Blanc, M. (1975) Middle and low latitude effects of...1730. 13. Bertin, F.J., Testud , J., Kersley, L., and Rees, P. R. (1978) The meteorological jet stream as a source of medium scale gravity waves in

  6. Quantitative Simulation of a Magnetospheric Substorm. 3. Plasmaspheric Electric Fields and Evolution of the Plasmapause.

    Science.gov (United States)

    1980-01-25

    plasmaspheric electric fields during magnetically disturbed periods are based on incoherent scatter radar results fromn St. Santin [ Testud et al., 1975...Millstone Hill radar results showing westward F-region ion drifts of almost 200 m/sec in the afternoon sector on 14 May, 1969. Testud et al. [1975...electrojet (AE) index. Testud et al. [1975] and Blanc et al. £1977] have both presented St. Santin backscatter measurements that show westward and

  7. Isotopically Anomalous Carbonaceous Nanoglobules in Meteorites and Comets

    Science.gov (United States)

    de Gregorio, B. T.; Alexander, C.; Bassim, N. D.; Cody, G. D.; Kilcoyne, D.; Nittler, L.; Stroud, R.; Zega, T. J.

    2009-12-01

    Sub-micron, spherical, organic globules are prevalent in primitive meteorites and interplanetary dust particles. Many of these globules are significantly enriched in 15N and/or D, relative to solar values, which suggest that they or their precursors formed in cold regions of the solar nebula or in interstellar molecular clouds. We have used correlated transmission electron microscopy (TEM), synchrotron-based X-ray absorption near-edge structure spectroscopy (XANES), and secondary ion mass spectrometry (SIMS) to determine the elemental and isotopic composition and organic functional group chemistry of individual carbonaceous nanoglobules in a suite of insoluble organic matter (IOM) residues prepared from carbonaceous and ordinary chondrites, and two additional organic globules from the Stardust comet 81P/Wild 2 sample collection. The majority of the meteoritic nanoglobules have a similar chemistry to the bulk IOM, with, on average, a small but significant enrichment in aromatic ketone (-C=O) and carboxyl (-COOH) functional groups. However, some of the meteoritic nanoglobules and one of the Stardust nanoglobules contain highly aromatic organic matter with no significant oxygen functionality. Preliminary measurements indicate that the highest 15N enrichments are associated with the highly aromatic nanoglobules and that aromatic nanoglobules are more prevalent in IOM from more primitive meteorites (e.g. Bells contains more aromatic globules than Murchison). For example, of two adjacent nanoglobules with nearly identical hollow morphologies from Murchison, one contains highly aromatic organic matter and the other contains oxidized IOM-like organic matter. SIMS analysis of these two globules reveals that the highly aromatic globule has the greatest 15N enrichment (δ15N ~ +500‰) of all meteoritic globules in which both XANES and SIMS was performed, whereas the adjacent IOM-like globule has a smaller 15N enrichment (δ15N ~ +300‰) but still greater than bulk IOM (δ15

  8. Derivation of muon range spectrum under rock from the recent primary spectrum

    International Nuclear Information System (INIS)

    Pal, P.; Bhattacharyya, D.P.

    1985-01-01

    The muon range spectra under Mont Blanc Tunnel and Kolar Gold Field rocks have been calculated from the recently measured primary cosmic ray spectrum. The scaling hypothesis of Feynman has been used for the calculation of pion and kaon spectra in the atmosphere. The meson atmospheric diffusion equation has been solved by following the method of Bugaev et al. The derived muon energy spectrum has been found to be in good agreement with the measured data of the Kiel, Durham, DEIS, and Moscow University groups. The calculated muon energy spectra at large polar angles have been compared with the different experimental results. The integral muon spectrum up to 20 TeV supports the MARS burst data favourably. Using the procedure of Kobayakawa, the muon energy loss in rock due to ionization, pair production, and bremsstrahlung and nuclear interactions from Bezrukov and Bugaev, we have constructed the range-energy relation in Mont Blanc and Kolar Gold Field rocks. The estimated range spectra have been corrected for range fluctuations and have been compared with the Mont Blanc Tunnel data of Castagnoli et al., Bergamasco et al., and Sheldon et al. and the Kolar Gold Field data compilation by Krishnaswamy et al

  9. Use of glutathione during white wine production – impact on S-off-flavors and sensory production

    Directory of Open Access Journals (Sweden)

    Wegmann-Herr Pascal

    2016-01-01

    Full Text Available Recently two OIV resolutions (OENO 445-2015 and OENO 446-2015 were adopted, defining the use of glutathione (GSH up to a maximum level of 20 mg/L in must and wine. Various studies have shown the benefits of GSH addition, especially in Sauvignon blanc wines. On the other hand, the formation of hydrogen sulfide (H2S and other S-off-flavors favored by GSH addition are reported. To investigate the effect of glutathione on the color development, the sensory expression and the formation of sulfide off-flavors, Riesling, Sauvignon Blanc and Chardonnay grapes were processed under different conditions and musts were obtained with different phenolic contents. By the addition of GSH as a pure substance or the use of GSH-rich inactivated yeast preparations, the GSH concentration in the musts was varied. Bottled wines showed generally lower GSH levels than the corresponding musts. However, higher GSH concentrations after yeast aging could be determined, which may explain increased protection against oxidation during further storage. The sensory analysis after bottling showed that the fruity character of Riesling and Sauvignon blancs was enhanced at moderate GSH addition. Overuse of GSH in musts with low phenolic content, however, can lead to sensory perceptible S-off-flavors in the later wines.

  10. Preto no branco?: mensuração, relevância e concordância classificatória no país da incerteza racial

    Directory of Open Access Journals (Sweden)

    Jerônimo O. Muniz

    2012-01-01

    Full Text Available Dans cet article, on cherche à savoir si, au Brésil, il y a similitude entre des modèles de classement racial selon quatre méthodologies de mensuration avec trois catégories (le blanc, le métis ou le noir ou deux catégories (le blanc ou le noir. L'incertitude taxinomique raciale est illustrée à partir d'estimations statistiquement sûres des probabilités d'être blanc ou noir, dont le contrôle se fait selon des traits individuels, la couleur de la peau des parents et divers schèmes de catégories. Selon les résultats, si différentes méthodes de prélèvement de données sont utilisées dans la construction de la variable couleur de la peau, seuls 50% des sujets affirment leur propre couleur de façon tranchée dans toutes les méthodes. Ces données sont tirées de la Recherche Sociale Brésilienne menée par l'Université Fédérale Fluminense (UFF en 2002, à partir d'un échantillon représentatif de la population nationale, le premier à permettre l'étude en question.

  11. Internal motions in H II regions. XII S162 and NGC 7635

    Energy Technology Data Exchange (ETDEWEB)

    Pismis, P; Moreno, M A; Hasse, I [Universidad Nacional Autonoma de Mexico, Mexico City

    1983-01-01

    The apparent structure of S162 and of the bubble nebula (NGC 7635) associated with it is discussed using a number of direct images taken through narrow band (10 A/sup 0/) interference filters in H..cap alpha.., (N II) and in the continuum at lambda6607. The results are discussed together with the radial velocity field of S162 and in particular of the bubble nebula as obtained from photographic Fabry-Perot interferometry. The bubble nebula is shown to be composed of distinct and amorphous very regularly curving arcs, all inscribed on a tenuous slightly ellipsoidal shell of gas expanding at velocity of about 4 km s/sup -1/. The arcs are probably genetically related to the globules which form the caracteristic comet like feature within the bubble nebula. The ionization source of S162 is BD + 60/sup 0/2522 and 071Isub(b)f star classified from our high dispersion spectrum. Our very tentative suggestion is that the brightest globule may be an offshoot fo this star and that the globule has generated the next globule which in turn may have generated the third one. The configuration of NGC 7635 suggests that magnetic fields are likely to be operative in the region. Polarimetry in the optical and in the radio range as well as high resolution infrared studies, high resolution velocity fields are desirable to find a satisfactory model for this nebula.

  12. Development of fermented milk “Leben” made from spontaneous ...

    African Journals Online (AJOL)

    Yomi

    2012-01-24

    Jan 24, 2012 ... shaking it back and forth till the coalescence of the fat globules. ... proteins, mesophilic lactis acid bacteria (LAB) were the predominant ... the following steps: five liters of raw milk was left spontaneously at. 25 ± 2°C in a jar ...

  13. Role of quaternary structure in muscle creatine kinase stability: tryptophan 210 is important for dimer cohesion.

    Science.gov (United States)

    Perraut, C; Clottes, E; Leydier, C; Vial, C; Marcillat, O

    1998-07-01

    A mutant of the dimeric rabbit muscle creatine kinase (MM-CK) in which tryptophan 210 was replaced has been studied to assess the role of this residue in dimer cohesion and the importance of the dimeric state for the native enzyme stability. Wild-type protein equilibrium unfolding induced by guanidine hydrochloride occurs through intermediate states with formation of a molten globule and a premolten globule. Unlike the wild-type enzyme, the mutant inactivates at lower denaturant concentration and the loss of enzymatic activity is accompanied by the dissociation of the dimer into two apparently compact monomers. However, the Stokes radius of the monomer increases with denaturant concentration as determined by size exclusion chromatography, indicating that, upon monomerization, the protein structure is destabilized. Binding of 8-anilinonaphthalene-1-sulfonate shows that the dissociated monomer exposes hydrophobic patches at its surface, suggesting that it could be a molten globule. At higher denaturant concentrations, both wild-type and mutant follow similar denaturation pathways with formation of a premolten globule around 1.5-M guanidine, indicating that tryptophan 210 does not contribute to a large extent to the monomer conformational stability, which may be ensured in the dimeric state through quaternary interactions.

  14. Macromolecular crowding compacts unfolded apoflavodoxin and causes severe aggregation of the off-pathway intermediate during apoflavodoxin folding

    NARCIS (Netherlands)

    Engel, R.; Westphal, A.H.; Huberts, D.; Nabuurs, S.M.; Lindhoud, S.; Visser, A.J.W.G.; Mierlo, van C.P.M.

    2008-01-01

    To understand how proteins fold in vivo, it is important to investigate the effects of macromolecular crowding on protein folding. Here, the influence of crowding on in vitro apoflavodoxin folding, which involves a relatively stable off-pathway intermediate with molten globule characteristics, is

  15. Spreading of oil from protein stabilised emulsions at air/water interfaces

    NARCIS (Netherlands)

    Schokker, E.P.; Bos, M.A.; Kuijpers, A.J.; Wijnen, M.E.; Walstra, P.

    2002-01-01

    Spreading of a drop of an emulsion made with milk proteins on air/water interfaces was studied. From an unheated emulsion, all oil molecules could spread onto the air/water interface, indicating that the protein layers around the oil globules in the emulsion droplet were not coherent enough to

  16. Radiation-hydrodynamics of HII regions and molecular clouds

    International Nuclear Information System (INIS)

    Sandford, M.T. II; Whitaker, R.W.; Klein, R.I.

    1981-01-01

    Two-dimensional calculations of ionization-shock fronts surrounding neutral cloud clumps reveal that a radiation-driven implosion of the clump can occur. The implosion of a cloud clump results in the formation of density enhancements that may eventually form low mass stars. The smaller globules produced may become Herbig-Haro objects, or maser sources

  17. Unfiltered beer

    DEFF Research Database (Denmark)

    Stensballe, Allan; Bennike, Tue

    2014-01-01

    Bovine milks content of phospholipid membranes have largely been explored in the cream fraction, and known as the milk fat globule membrane that surrounds fat droplets. In skim milk, the population of phospholipid membranes is reported to constitute membrane vesicles with a soluble content known ...

  18. Regulation of gene expression in human mammary epithelium: effect of breast pumping

    Science.gov (United States)

    Little is known of the molecular regulation of human milk production because of limitations in obtaining mammary tissue from lactating women. Our objectives were to evaluate whether RNA isolated from breast milk fat globules (MFGs) could be an alternative to mammary biopsies and to determine whether...

  19. A simple approach to the solvent reorganisation Gibbs free energy in electron transfer reactions of redox metalloproteins

    DEFF Research Database (Denmark)

    Ulstrup, Jens

    1999-01-01

    We discuss a simple model for the environmental reorganisation Gibbs free energy, E-r, in electron transfer between a metalloprotein and a small reaction partner. The protein is represented as a dielectric globule with low dielectric constant, the metal centres as conducting spheres, all embedded...

  20. Self-consistent-field calculations of proteinlike incorporations in polyelectrolyte complex micelles

    NARCIS (Netherlands)

    Lindhoud, S.; Cohen Stuart, M.A.; Norde, W.; Leermakers, F.A.M.

    2009-01-01

    Self-consistent field theory is applied to model the structure and stability of polyelectrolyte complex micelles with incorporated protein (molten globule) molecules in the core. The electrostatic interactions that drive the micelle formation are mimicked by nearest-neighbor interactions using

  1. Microstructure of milk

    Science.gov (United States)

    The fat and protein in milk may be examined by scanning electron microscopy, transmission electron microscopy, and confocal laser scanning microscopy, and any bacteria present may be viewed by light microscopy. The fat exists as globules, the bulk of the protein is in the form of casein micelles, a...

  2. Étude de la qualité biochimique et nutritionnelle de la poudre ...

    African Journals Online (AJOL)

    SARAH

    31 déc. 2015 ... composition de cet animal a été déterminée : 7,19 g d'eau et de 2,36 g de cendres pour ... voisine de celle de la viande et du poisson qui sont plus onéreux pour les ..... est un constituant fondamental des globules rouges. Sa.

  3. 3D primary grain shapes resulting from semi-solid metal processing

    CSIR Research Space (South Africa)

    Curle, Ulyate A

    2017-07-01

    Full Text Available ) size. Are these 2D globules also spherical in shape in 3D or are these 2D shapes remnants of the 3D shapes after sectioning along planes? An Al-Si-Mg alloy is semi-solid processed using a patented processing coil that induces contactless stirring while...

  4. Thermodynamic and kinetic analysis of phase separation of temperature-sensitive poly(vinyl methyl ether) in the presence of hydrophobic tert-butyl alcohol

    Czech Academy of Sciences Publication Activity Database

    Velychkivska, Nadiia; Bogomolova, Anna; Filippov, Sergey K.; Starovoytova, Larisa; Labuta, J.

    2017-01-01

    Roč. 295, č. 8 (2017), s. 1419-1428 ISSN 0303-402X R&D Projects: GA ČR(CZ) GC15-10527J Institutional support: RVO:61389013 Keywords : phase separation * coil-globule transition * poly(vinyl methyl ether) Subject RIV: CF - Physical ; Theoretical Chemistry OBOR OECD: Physical chemistry Impact factor: 1.723, year: 2016

  5. Transient human anti-mouse antibodies (HAMA) interference in CA 125 measurements during monitoring of ovarian cancer patients treated with murine monoclonal antibody.

    NARCIS (Netherlands)

    Oei, A.L.M.; Sweep, F.C.; Massuger, L.F.A.G.; Olthaar, A.J.; Thomas, C.M.G.

    2008-01-01

    OBJECTIVE: To investigate the influence of human anti-mouse antibodies (HAMA) on serial CA 125 measurements in serum of patients with epithelial ovarian cancer following single intraperitoneal (IP) therapy with Yttrium-90-labeled human milk fat globule 1 murine monoclonal antibody ((90)Y-muHMFG1) as

  6. Untitled

    Indian Academy of Sciences (India)

    turing a mylar diaphragm with high pressure argon gas. The globule travels at a speed of 300 m sec and is splatted against an inclined copper substrate. Heat extraction by conduction is efficient and provides cooling rates of the order of. 10 KSec. An adaptation of the Duwez design has been extensively used in. Varanasi ...

  7. Lymphoid cells in chicken intestinal epithelium

    DEFF Research Database (Denmark)

    Bjerregaard, P

    1975-01-01

    The intraepithelial lymphoid cells of chicken small intestine were studied by light microscopy using 1 mu Epon sections, and by electron microscopy. Three cell types were found: small lymphocytes, large lymphoid cells, and granular cells. These cells correspond to the theliolymphocytes and globule...

  8. FORMULATION AND CHARACTERIZATION OF A MULTIPLE ...

    African Journals Online (AJOL)

    Preferred Customer

    Vitamin C, was incorporated into the inner aqueous phase of water-in-oil-in-water ... Multiple emulsion was prepared by two step method. ... that there was no significant change (p > 0.05) in globule sizes in most of the samples ... advantages of prolonged release of active agent, incorporation of incompatible materials and.

  9. Homogenization conditions affect the oxidative stability of fish oil enriched milk emulsions: Oxidation linked to changes in protein composition at the oil-water interface

    DEFF Research Database (Denmark)

    Sørensen, Ann-Dorit Moltke; Baron, Caroline; Bruni Let, Mette

    2007-01-01

    Fish oil was incorporated into milk under different homogenization temperatures (50 and 72 °C) and pressures (5, 15, and 22.5 MPa). Subsequently, the oxidative stability of the milk and changes in the protein composition of the milk fat globule membrane (MFGM) were examined. Results showed...

  10. Diffusie van zout en water bij het zouten van kaas

    NARCIS (Netherlands)

    Geurts, T.J.

    1972-01-01

    In experiments on the brining of cheese, displacement of salt in cheese could be adequately described by a diffusion process. A simple model on the structure of the cheese matrix (fat globules and protein), allowing for friction and labyrinth effects, explained the lower value for the pseudo

  11. The utility of periodic acid schiff with diastase and alcian blue stains on fine needle aspirates of breast and salivary gland neoplasms

    Directory of Open Access Journals (Sweden)

    N K Panicker

    2012-01-01

    Conclusion : Intracytoplasmic PAS-D-positive globules may be useful in differentiating benign and malignant lesions of breast. The presence of PAS-D positive granules are useful in differentiating various lesions of salivary glands. AB staining of stromal fragments in pleomorphic adenoma is useful in differentiating it from basal cell adenoma.

  12. 63 a review of reproduction and gamete management in the african ...

    African Journals Online (AJOL)

    2005-02-16

    Feb 16, 2005 ... gariepinus show altrical or continuum of alternative reproductive style (Bruton, 1989). The fish is an egg scatterer which awaits suitable environmental condition before ... associated the increased number of granules and globules to ..... produce fingerlings with decreased fitness noticeable after only a few ...

  13. A Herschel view of IC 1396 A: Unveiling the different sequences of star formation

    NARCIS (Netherlands)

    Sicilia-Aguilar, Aurora; Roccatagliata, Veronica; Getman, Konstantin; Henning, Thomas; Merín, Bruno; Eiroa, Carlos; Rivière-Marichalar, Pablo; Currie, Thayne

    Context. The IC 1396 A globule, located to the west of the young cluster Tr 37, is known to host many very young stars and protostars, and is also assumed to be a site of triggered star formation. Aims: Our aim is to test the triggering mechanisms and sequences leading to star formation in Tr 37 and

  14. DNA compaction by azobenzene-containing surfactant

    International Nuclear Information System (INIS)

    Zakrevskyy, Yuriy; Kopyshev, Alexey; Lomadze, Nino; Santer, Svetlana; Morozova, Elena; Lysyakova, Ludmila; Kasyanenko, Nina

    2011-01-01

    We report on the interaction of cationic azobenzene-containing surfactant with DNA investigated by absorption and fluorescence spectroscopy, dynamic light scattering, and atomic force microscopy. The properties of the surfactant can be controlled with light by reversible switching of the azobenzene unit, incorporated into the surfactant tail, between a hydrophobic trans (visible irradiation) and a hydrophilic cis (UV irradiation) configuration. The influence of the trans-cis isomerization of the azobenzene on the compaction process of DNA molecules and the role of both isomers in the formation and colloidal stability of DNA-surfactant complexes is discussed. It is shown that the trans isomer plays a major role in the DNA compaction process. The influence of the cis isomer on the DNA coil configuration is rather small. The construction of a phase diagram of the DNA concentration versus surfactant/DNA charge ratio allows distancing between three major phases: colloidally stable and unstable compacted globules, and extended coil conformation. There is a critical concentration of DNA above which the compacted globules can be hindered from aggregation and precipitation by adding an appropriate amount of the surfactant in the trans configuration. This is because of the compensation of hydrophobicity of the globules with an increasing amount of the surfactant. Below the critical DNA concentration, the compacted globules are colloidally stable and can be reversibly transferred with light to an extended coil state.

  15. Atomic force microscopy of the intervessel pit membrane in the stem of Sapium sebiferum (Euphorbiacea)

    Science.gov (United States)

    Thomas C. Pesacreta; Leslie H. Groom; Timothy G. Rials

    2005-01-01

    Sapwood and juvenile wood of Sapium sebiferum (Euphorbiacea) was collected during 2000-2002. In air-dried vessel elements, the surface of pit membranes (PMs) in the outermost growth ring was coated with plaque-like or interstitial material that was 2-5 nm thick. This coating was phase dark and overlaid a phase bright layer of globules and...

  16. A micro-scale investigation of melt production and extraction in the upper mantle based on silicate melt pockets in ultramafic xenoliths from the Bakony-Balaton Highland Volcanic Field (Western Hungary)

    DEFF Research Database (Denmark)

    Bali, Eniko; Zanetti, A.; Szabo, C.

    2008-01-01

    Mantle xenoliths in Neogene alkali basalts of the Bakony-Balaton Highland Volcanic Field (Western Hungary) frequently have melt pockets that contain silicate minerals, glass, and often carbonate globules. Textural, geochemical and thermobarometric data indicate that the melt pockets formed at rel...

  17. Effects of Allelochemicals of Some Eucalyptus Species on ...

    African Journals Online (AJOL)

    A laboratory experiment was conducted to assess the effects of allelochemicals of Eucalyptus camaldulensis, Eucalyptus citriodora and Eucalyptus globules on germination and root elongation using leguminous crop ground nut (Arachis hypogea) as bioassay material. The experiments were conducted in sterilized ...

  18. Diagram of state of stiff amphiphilic macromolecules

    NARCIS (Netherlands)

    Markov, Vladimir A.; Vasilevskaya, Valentina V.; Khalatur, Pavel G.; ten Brinke, Gerrit; Khokhlov, Alexei R.

    2007-01-01

    We studied coil-globule transitions in stiff-chain amphiphilic macromolecules via computer modeling and constructed phase diagrams for such molecules in terms of solvent quality and persistence length. We showed that the shape of the phase diagram essentially depends on the macromolecule degree of

  19. Conformational properties of rigid-chain amphiphilic macromolecules : The phase diagram

    NARCIS (Netherlands)

    Markov, V. A.; Vasilevskaya, V. V.; Khalatur, P. G.; ten Brinke, G.; Khokhlov, A. R.

    The coil-globule transition in rigid-chain amphiphilic macromolecules was studied by means of computer simulation, and the phase diagrams for such molecules in the solvent quality-persistence length coordinates were constructed. It was shown that the type of phase diagram depends to a substantial

  20. Carotenoid fluorescence in Dunaliella salina

    NARCIS (Netherlands)

    Kleinegris, D.M.M.; Es, van M.A.; Janssen, M.G.J.; Brandenburg, W.A.; Wijffels, R.H.

    2010-01-01

    Dunaliella salina is a halotolerant green alga that is well known for its carotenoid producing capacity. The produced carotenoids are mainly stored in lipid globules. For various research purposes, such as production and extraction kinetics, we would like to determine and/or localise the carotenoid