WorldWideScience

Sample records for global mechanical integrity

  1. INTEGRATED MECHANISMS FOR APROACHING PRIORITY ENVIRONMENTAL ISSUES AT GLOBAL LEVEL

    iLDIKO iOAN

    2011-03-01

    Full Text Available Integrated mechanisms for approaching priority environmentalissues at global level. At global level, there are considered priorityenvironmental issues two interdependent processes that are essential for thesupport the processes that provide living conditions and wellbeing for the entirehumankind: climate change and loss of biodiversity. Payments of ecosystemservices became already well-known and applied economic instruments, althoughthere are still many uncertainties in the knowledge of eco-economic interdependencies.The paper discusses these aspects in the first part highlighting advantagesand disadvantages, while in the second part there is analyzed an integratedprogram of the United Nations, which was designed for making progress towardboth climate change, and loss of biodiversity. The REDD program – Reduction ofEmissions from Deforestation and forest Degradation – is addressed to developingcountries and it started in 2008. Based on assessment reports we will try toformulate a number of conclusions regarding the program’s effectiveness.

  2. European Integration and Globalization

    Diana Bobica

    2010-06-01

    Full Text Available According to many, the term globalization is able to explain any phenomenon whatsoever, be it positive or negative, that takes place within the global social system. It seems like a sort of magical formula, which is to be found in the speeches of all sorts of people, be they economists, politicians, businessmen or sociologists. However this magical formula of globalization has its limitations, since it encompasses a certain amount of quibbling, beyond which not many can pass. In the context of globalization there appears the question on its role in the process of European integration. Is European integration a part of this global process or, quite on the contrary, does it present certain distinctive features, as it moulds itself differently from the globalization phenomenon? A clear-cut answer seems difficult because of the various aspects involved. Not only the general phenomenon of globalization, but also the economic integration on European level is based on the liberalization of markets and on the opening of national economies towards the exterior,having as direct consequence the intensification of trade exchanges. If from a global point of view one may talk of a market fundamentalism in that the market principles know no boundary, European integration on the other hand implies not only market economy, but also a guided and monitored action of Member Statesaccording to the needs of the whole entity, also taking into consideration - as far as possible – all aspects and consequences on social level.

  3. GLobal Integrated Design Environment

    Kunkel, Matthew; McGuire, Melissa; Smith, David A.; Gefert, Leon P.

    2011-01-01

    The GLobal Integrated Design Environment (GLIDE) is a collaborative engineering application built to resolve the design session issues of real-time passing of data between multiple discipline experts in a collaborative environment. Utilizing Web protocols and multiple programming languages, GLIDE allows engineers to use the applications to which they are accustomed in this case, Excel to send and receive datasets via the Internet to a database-driven Web server. Traditionally, a collaborative design session consists of one or more engineers representing each discipline meeting together in a single location. The discipline leads exchange parameters and iterate through their respective processes to converge on an acceptable dataset. In cases in which the engineers are unable to meet, their parameters are passed via e-mail, telephone, facsimile, or even postal mail. The result of this slow process of data exchange would elongate a design session to weeks or even months. While the iterative process remains in place, software can now exchange parameters securely and efficiently, while at the same time allowing for much more information about a design session to be made available. GLIDE is written in a compilation of several programming languages, including REALbasic, PHP, and Microsoft Visual Basic. GLIDE client installers are available to download for both Microsoft Windows and Macintosh systems. The GLIDE client software is compatible with Microsoft Excel 2000 or later on Windows systems, and with Microsoft Excel X or later on Macintosh systems. GLIDE follows the Client-Server paradigm, transferring encrypted and compressed data via standard Web protocols. Currently, the engineers use Excel as a front end to the GLIDE Client, as many of their custom tools run in Excel.

  4. Integrated Surface Dataset (Global)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Integrated Surface (ISD) Dataset (ISD) is composed of worldwide surface weather observations from over 35,000 stations, though the best spatial coverage is...

  5. Mechanical integrity of canisters

    Nilsson, Fred

    1992-12-01

    This document constitutes the final report from 'SKBs reference group for mechanical integrity of canisters for spent nuclear fuel'. A complete list of all reports initiated by the reference group can be found in the summary report in this document. The main task of the reference group has been to advice SKB regarding the choice (ranking of alternatives) of canister type for different types of storage. The choice should be based on requirements of impermeability for a given time period and identification of possible limiting mechanisms. The main conclusions from the work were: From mechanical point of view, low phosphorous oxygen free copper (Cu-OFP) is a preferred canisters material. It exhibits satisfactory ductility both during tensile and creep testing. The residual stresses in the canisters are of such a magnitude that the estimated time to creep rupture with the data obtained for the Cu-OFP material is essentially infinite. Based on the present knowledge of stress corrosion cracking of copper there appears to be a small risk for such to occur in the projected environment. This risk need some further study. Rock shear movements of the size of 10 cm should pose no direct threat to the integrity of the canisters. Considering mechanical integrity, the composite copper/steel canister is an advantageous alternative. The recommendations for further research included continued studies of the creep properties of copper and of stress corrosion cracking. However, the studies should focus more directly on the design and fabrication aspect of the canister

  6. Eurasia: The Rivalry of Global Integration Projects

    Olesia Kobenko

    2016-05-01

    Full Text Available The article reveals the Eurasian integration projects as major drivers of world globalization. Eurasian regionalism seems to be gaining attention in the scientific literature. Under the current political circumstance many regions are accelerating integration and many countries are opting for regional associations as a mechanism to help them overcome the global recession. Moreover, the global political leaders , some developed countries - the U.S., China, and the European Union (EU are interested to set up regional economic blocs such as Eurasian Economic Union (The EEU, the China's project 'One Belt One Road', the U.S's projects - The Trans-Pacific Partnership (TPP and The Transatlantic Trade and Investment Partnership (TTIP. The goal of this paper is to introduce a number of integration initiatives and to analyze the current strategies of Eurasian regionalism.

  7. Classical Mechanics and Symplectic Integration

    Nordkvist, Nikolaj; Hjorth, Poul G.

    2005-01-01

    Content: Classical mechanics: Calculus of variations, Lagrange’s equations, Symmetries and Noether’s theorem, Hamilton’s equations, cannonical transformations, integrable systems, pertubation theory. Symplectic integration: Numerical integrators, symplectic integrators, main theorem on symplectic...

  8. Integrated global digital image correlation for interface delamination characterization

    Hoefnagels, Johan P.M.; Blaysat, Benoî t; Lubineau, Gilles; Geers, Marc G D

    2013-01-01

    , but require accurate interface models to capture (irreversible) crack initiation and propagation behavior observed in experiments. Therefore, an Integrated Global Digital Image Correlation (I-GDIC) strategy is developed for accurate determination of mechanical

  9. Global aspects of classical integrable systems

    Cushman, Richard H

    2015-01-01

    This book gives a uniquely complete description of the geometry of the energy momentum mapping of five classical integrable systems: the 2-dimensional harmonic oscillator, the geodesic flow on the 3-sphere, the Euler top, the spherical pendulum and the Lagrange top. It presents for the first time in book form a general theory of symmetry reduction which allows one to reduce the symmetries in the spherical pendulum and the Lagrange top. Also the monodromy obstruction to the existence of global action angle coordinates is calculated for the spherical pendulum and the Lagrange top. The book addresses professional mathematicians and graduate students and can be used as a textbook on advanced classical mechanics or global analysis.

  10. Global integration in times of crisis

    Jensen, Camilla

    shock) from other subsidiaries downstream in the value chain. While in a comparative perspective multinational subsidiaries are found to perform relatively better than local firms that are integrated differently (arms' length) in global production networks (e.g. offshoring outsourcing). This paper tries...... to reconcile these findings by testing a number of hypothesis about global integration strategies in the context of the global financial crisis and how it affected exporting among multinational subsidiaries operating out of Turkey. Controlling for the impact that depreciations and exchange rate volatility has...... integration strategies throughout the course of the global financial crisis....

  11. Integrating cognitive (neuroscience using mechanisms

    Marcin Miłkowski

    2016-11-01

    Full Text Available In this paper, an account of theoretical integration in cognitive (neuroscience from the mechanistic perspective is defended. It is argued that mechanistic patterns of integration can be better understood in terms of constraints on representations of mechanisms, not just on the space of possible mechanisms, as previous accounts of integration had it. This way, integration can be analyzed in more detail with the help of constraintsatisfaction account of coherence between scientific represen-tations. In particular, the account has resources to talk of idealizations and research heuristics employed by researchers to combine separate results and theoretical frameworks. The account is subsequently applied to an example of successful integration in the research on hippocampus and memory, and to a failure of integration in the research on mirror neurons as purportedly explanatory of sexual orientation.

  12. Integrated Global Radiosonde Archive (IGRA) Version 2

    National Oceanic and Atmospheric Administration, Department of Commerce — Integrated Global Radiosonde Archive (IGRA) Version 2 consists of quality-controlled radiosonde observations of temperature, humidity, and wind at stations across...

  13. The global economic integration has no prospects without global currency

    Sajnoski, Krste; Paceskoski, Vlatko; Davcev, Ljupco

    2013-01-01

    After getting out of the recession as it is, into which the developed countries have fallen, the continuation of the processes of global economic integration becomes a priority task of the contemporary international economic relations. For its accomplishment, there has to be stopped the sharpening of global imbalances, it has to be ceased the taking of protectionist measures in relation to the competing economies, to be eliminated the danger of carrying out competing devaluations of national ...

  14. Integrated risk analysis of global climate change

    Shlyakhter, Alexander; Wilson, Richard; Valverde A, L.J. Jr.

    1995-01-01

    This paper discusses several factors that should be considered in integrated risk analyses of global climate change. We begin by describing how the problem of global climate change can be subdivided into largely independent parts that can be linked together in an analytically tractable fashion. Uncertainty plays a central role in integrated risk analyses of global climate change. Accordingly, we consider various aspects of uncertainty as they relate to the climate change problem. We also consider the impacts of these uncertainties on various risk management issues, such as sequential decision strategies, value of information, and problems of interregional and intergenerational equity. (author)

  15. Path Integrals in Quantum Mechanics

    Louko, J

    2005-01-01

    Jean Zinn-Justin's textbook Path Integrals in Quantum Mechanics aims to familiarize the reader with the path integral as a calculational tool in quantum mechanics and field theory. The emphasis is on quantum statistical mechanics, starting with the partition function Tr exp(-β H) and proceeding through the diffusion equation to barrier penetration problems and their semiclassical limit. The 'real time' path integral is defined via analytic continuation and used for the path-integral representation of the nonrelativistic S-matrix and its perturbative expansion. Holomorphic and Grassmannian path integrals are introduced and applied to nonrelativistic quantum field theory. There is also a brief discussion of path integrals in phase space. The introduction includes a brief historical review of path integrals, supported by a bibliography with some 40 entries. As emphasized in the introduction, mathematical rigour is not a central issue in the book. This allows the text to present the calculational techniques in a very readable manner: much of the text consists of worked-out examples, such as the quartic anharmonic oscillator in the barrier penetration chapter. At the end of each chapter there are exercises, some of which are of elementary coursework type, but the majority are more in the style of extended examples. Most of the exercises indeed include the solution or a sketch thereof. The book assumes minimal previous knowledge of quantum mechanics, and some basic quantum mechanical notation is collected in an appendix. The material has a large overlap with selected chapters in the author's thousand-page textbook Quantum Field Theory and Critical Phenomena (2002 Oxford: Clarendon). The stand-alone scope of the present work has, however, allowed a more focussed organization of this material, especially in the chapters on, respectively, holomorphic and Grassmannian path integrals. In my view the book accomplishes its aim admirably and is eminently usable as a textbook

  16. Path Integrals in Quantum Mechanics

    Chetouani, L

    2005-01-01

    By treating path integrals the author, in this book, places at the disposal of the reader a modern tool for the comprehension of standard quantum mechanics. Thus the most important applications, such as the tunnel effect, the diffusion matrix, etc, are presented from an original point of view on the action S of classical mechanics while having it play a central role in quantum mechanics. What also emerges is that the path integral describes these applications more richly than are described traditionally by differential equations, and consequently explains them more fully. The book is certainly of high quality in all aspects: original in presentation, rigorous in the demonstrations, judicious in the choice of exercises and, finally, modern, for example in the treatment of the tunnel effect by the method of instantons. Moreover, the correspondence that exists between classical and quantum mechanics is well underlined. I thus highly recommend this book (the French version being already available) to those who wish to familiarize themselves with formulation by path integrals. They will find, in addition, interesting topics suitable for exploring further. (book review)

  17. Integrated Water Resources Management: A Global Review

    Srinivasan, V.; Cohen, M.; Akudago, J.; Keith, D.; Palaniappan, M.

    2011-12-01

    The diversity of water resources endowments and the societal arrangements to use, manage, and govern water makes defining a single paradigm or lens through which to define, prioritize and evaluate interventions in the water sector particularly challenging. Integrated Water Resources Management (IWRM) emerged as the dominant intervention paradigm for water sector interventions in the early 1990s. Since then, while many successful implementations of IWRM have been demonstrated at the local, basin, national and trans-national scales, IWRM has also been severely criticized by the global water community as "having a dubious record that has never been comprehensively analyzed", "curiously ambiguous", and "ineffective at best and counterproductive at worst". Does IWRM hold together as a coherent paradigm or is it a convenient buzzword to describe a diverse collection of water sector interventions? We analyzed 184 case study summaries of IWRM interventions on the Global Water Partnership (GWP) website. The case studies were assessed to find the nature, scale, objectives and outcomes of IWRM. The analysis does not suggest any coherence in IWRM as a paradigm - but does indicate distinct regional trends in IWRM. First, IWRM was done at very different scales in different regions. In Africa two-thirds of the IWRM interventions involved creating national or transnational organizations. In contrast, in Asia and South America, almost two-thirds were watershed, basin, or local body initiatives. Second, IWRM interventions involved very different types of activities in different regions. In Africa and Europe, IWRM entailed creation of policy documents, basin plans and institution building. In contrast, in Asia and Latin America the interventions were much more likely to entail new technology, infrastructure or watershed measures. In Australia, economic measures, new laws and enforcement mechanisms were more commonly used than anywhere else.

  18. Global change integrating factors: Tropical tropopause trends

    Reck, R.A.

    1994-01-01

    This research proposes new criteria, shifts in the height and temperature of the tropical tropopause, as measures of global climate change. The search for signs of global warming in the temperature signal near the earth's surface is extremely difficult, largely because numerous factors contribute to surface temperature forcing with only a small signal-to-noise ratio relative to long-term effects. In the long term, no part of the atmosphere can be considered individually because the evolution will be a function of all states of all portions. A large surface greenhouse signal might ultimately be expected, but the analysis of surface temperature may not be particularly useful for early detection. What is suggested here is not an analysis of trends in the surface temperature field or any of its spatial averages, but rather an integrating factor or integrator, a single measure of global change that could be considered a test of significant change for the entire global system. Preferably, this global change integrator would vary slowly and would take into account many of the causes of climate change, with a relatively large signal-to-noise ratio. Such an integrator could be monitored, and abrupt or accelerated changes could serve as an early warning signal for policy makers and the public. Earlier work has suggested that temperature has much less short-term and small-scale noise in the lower stratosphere, and thus the global warming signal at that level might be more easily deconvoluted, because the cooling rate near the 200-mb level is almost constant with latitude. A study of the temperature signal at this pressure level might show a clearer trend due to increased levels of greenhouse gases, but it would yield information about the troposphere only by inference

  19. Global Governance Mechanisms to Address Antimicrobial Resistance.

    Padiyara, Ponnu; Inoue, Hajime; Sprenger, Marc

    2018-01-01

    Since their discovery, antibiotics, and more broadly, antimicrobials, have been a cornerstone of modern medicine. But the overuse and misuse of these drugs have led to rising rates of antimicrobial resistance, which occurs when bacteria adapt in ways that render antibiotics ineffective. A world without effective antibiotics can have drastic impacts on population health, global development, and the global economy. As a global common good, antibiotic effectiveness is vulnerable to the tragedy of the commons, where a shared limited resource is overused by a community when each individual exploits the finite resource for their own benefit. A borderless threat like antimicrobial resistance requires global governance mechanisms to mitigate its emergence and spread, and it is the responsibility of all countries and relevant multilateral organizations. These mechanisms can be in the form of legally binding global governance mechanisms such as treaties and regulatory standards or nonbinding mechanisms such as political declarations, resolutions, or guidelines. In this article, we argue that while both are effective methods, the strong, swift, and coordinated action needed to address rising rates of antimicrobial resistance will be better served through legally binding governance mechanisms.

  20. Economic Globalization - a Phenomenon of Global Business Integration

    Radu-Marcel Joia

    2012-05-01

    Full Text Available Tumultuous economic life led scientists to seek explanations to the negative economic events,events that take many forms, and to whom it is a must to find a solution or even a mitigating factor. Thefoundation of the economy has undergone many changes. The recent events manifested in the world economyshow that the underlying fundamentals of this science must be revised because they proved to be wrong. Itnotes several times, mainly due to present economic crisis, that currently the economics have no theoreticaland practical means and no tools of analysis and intervention in the economy, proving that the existing onesare exceeded and insufficient, so that the creation of an unifying principle and of some generalizing conceptsthat could systematize and forecast the current economic phenomena in the microeconomics andmacroeconomics, especially in the transnational companies field, those which are the base of the foreigndirect investment flows, should become the main objective of the new economic science. Through this paper,we tried to illustrate the important aspects of economic globalization, the challenges that this phenomenonposes to economies and the way in which an economy can become globally competitive, under massiveconstraints of the global competition, how a national company can become globally integrated, study basedon representative references.

  1. The mechanisms of collinear integration.

    Cass, John; Alais, David

    2006-08-11

    Low-contrast visual contour fragments are easier to detect when presented in the context of nearby collinear contour elements (U. Polat & D. Sagi, 1993). The spatial and temporal determinants of this collinear facilitation have been studied extensively (J. R. Cass & B. Spehar, 2005; Y. Tanaka & D. Sagi, 1998; C. B. Williams & R. F. Hess, 1998), although considerable debate surrounds the neural mechanisms underlying it. Our study examines this question using a novel stimulus, whereby the flanking "contour" elements are rotated around their own axis. By measuring contrast detection thresholds to a brief foveal target presented at various phases of flanker rotation, we find peak facilitation after flankers have rotated beyond their collinear phase. This optimal facilitative delay increases monotonically as a function of target-flanker separation, yielding estimates of cortical propagation of 0.1 m/s, a value highly consistent with the dynamics of long-range horizontal interactions observed within primary visual cortex (V1). A curious new finding is also observed: Facilitative peaks also occur when the target flash precedes flanker collinearity by 20-80 ms, a range consistent with contrast-dependent cortical onset latencies. Together, these data suggest that collinear facilitation involves two separate mechanisms, each possessing distinct dynamics: (i) slowly propagating horizontal interactions within V1 and (ii) a faster integrative mechanism, possibly driven by synchronous collinear cortical onset.

  2. Implementation of U.S. Global Goals: Continental Integration Context

    Yaroslava Stolyarchuk

    2013-02-01

    Full Text Available The article provides efficiency assessment regarding existing mechanisms of the U.S. national interests’ implementation at the global level in terms of international competition aggravation and formation of the new global economic competition centers. Based on comparative analysis of the leverage for U.S. leadership in global competition it has been proven that currently the highest efficiency is demonstrated by the integration strategies of the USA in Latin America focused on maximizing implementation of the economic interests of U.S. transnational corporations in the region. It has been proven that the observed profound asymmetries regarding socio-economic development of the North and Latin America countries objectively requires implementation of the effective institutional mechanisms for leveling the negative effects generated by the trade and investment liberalization processes.

  3. Globalization and Integration Processes in Europe

    Beti Godnič

    2017-03-01

    Full Text Available Research Question (RQ: In the article we highlight the issue of whether Integration processes in the European Union are only a manifestation of these Globalization processes and if there are differences in the the old member States EU (15 and the new EU member states in changed micro and macro environment? Purpose: We wanted to determine how the old member States EU (15 and the new EU member states adapt to the new circumstances and other changes in the micro and macro environment. Method: Analysing complexity of the changes of the state of economic system, and complex fundamental global processes, which have been occurred in long period of time, need to supplement the pure scientific approach with other types of research work, more holistic approach, which is commonly used in Comparative economics. We have taken such an approach in this article. Results: In the article we studied the geopolitical changes in the micro and macro environment. We found that the development in the old EU member states EU-15 and in the new EU member states is different. EU havent addopted the harmonised economic policy which will solve the »North-South« problem and cross-state cultural consensus and find a way to operate systemically in global environment. Organization: The findings can be used to support undestanding of micro and macro envirnment of the companys and contribute for better strategic planning and design of the entire supply chain. Society: The findings can contribute to better understanding of integrative processes in the EU. Limitations/Future Research: The complexity of the problem and the dynamic changes in the functioning of the global market requires in-depth studiying of changes in the micro and macro environment of logistics companie

  4. Global human capital: integrating education and population.

    Lutz, Wolfgang; KC, Samir

    2011-07-29

    Almost universally, women with higher levels of education have fewer children. Better education is associated with lower mortality, better health, and different migration patterns. Hence, the global population outlook depends greatly on further progress in education, particularly of young women. By 2050, the highest and lowest education scenarios--assuming identical education-specific fertility rates--result in world population sizes of 8.9 and 10.0 billion, respectively. Better education also matters for human development, including health, economic growth, and democracy. Existing methods of multi-state demography can quantitatively integrate education into standard demographic analysis, thus adding the "quality" dimension.

  5. Default Mode Dynamics for Global Functional Integration.

    Vatansever, Deniz; Menon, David K; Manktelow, Anne E; Sahakian, Barbara J; Stamatakis, Emmanuel A

    2015-11-18

    The default mode network (DMN) has been traditionally assumed to hinder behavioral performance in externally focused, goal-directed paradigms and to provide no active contribution to human cognition. However, recent evidence suggests greater DMN activity in an array of tasks, especially those that involve self-referential and memory-based processing. Although data that robustly demonstrate a comprehensive functional role for DMN remains relatively scarce, the global workspace framework, which implicates the DMN in global information integration for conscious processing, can potentially provide an explanation for the broad range of higher-order paradigms that report DMN involvement. We used graph theoretical measures to assess the contribution of the DMN to global functional connectivity dynamics in 22 healthy volunteers during an fMRI-based n-back working-memory paradigm with parametric increases in difficulty. Our predominant finding is that brain modularity decreases with greater task demands, thus adapting a more global workspace configuration, in direct relation to increases in reaction times to correct responses. Flexible default mode regions dynamically switch community memberships and display significant changes in their nodal participation coefficient and strength, which may reflect the observed whole-brain changes in functional connectivity architecture. These findings have important implications for our understanding of healthy brain function, as they suggest a central role for the DMN in higher cognitive processing. The default mode network (DMN) has been shown to increase its activity during the absence of external stimulation, and hence was historically assumed to disengage during goal-directed tasks. Recent evidence, however, implicates the DMN in self-referential and memory-based processing. We provide robust evidence for this network's active contribution to working memory by revealing dynamic reconfiguration in its interactions with other networks

  6. Integrated assessment models of global climate change

    Parson, E.A.; Fisher-Vanden, K.

    1997-01-01

    The authors review recent work in the integrated assessment modeling of global climate change. This field has grown rapidly since 1990. Integrated assessment models seek to combine knowledge from multiple disciplines in formal integrated representations; inform policy-making, structure knowledge, and prioritize key uncertainties; and advance knowledge of broad system linkages and feedbacks, particularly between socio-economic and bio-physical processes. They may combine simplified representations of the socio-economic determinants of greenhouse gas emissions, the atmosphere and oceans, impacts on human activities and ecosystems, and potential policies and responses. The authors summarize current projects, grouping them according to whether they emphasize the dynamics of emissions control and optimal policy-making, uncertainty, or spatial detail. They review the few significant insights that have been claimed from work to date and identify important challenges for integrated assessment modeling in its relationships to disciplinary knowledge and to broader assessment seeking to inform policy- and decision-making. 192 refs., 2 figs

  7. Natural color image segmentation using integrated mechanism

    Jie Xu (徐杰); Pengfei Shi (施鹏飞)

    2003-01-01

    A new method for natural color image segmentation using integrated mechanism is proposed in this paper.Edges are first detected in term of the high phase congruency in the gray-level image. K-mean cluster is used to label long edge lines based on the global color information to estimate roughly the distribution of objects in the image, while short ones are merged based on their positions and local color differences to eliminate the negative affection caused by texture or other trivial features in image. Region growing technique is employed to achieve final segmentation results. The proposed method unifies edges, whole and local color distributions, as well as spatial information to solve the natural image segmentation problem.The feasibility and effectiveness of this method have been demonstrated by various experiments.

  8. Integrated Global Nuclear Materials Management Preliminary Concepts

    Jones, E; Dreicer, M.

    2006-01-01

    The world is at a turning point, moving away from the Cold War nuclear legacy towards a future global nuclear enterprise; and this presents a transformational challenge for nuclear materials management. Achieving safety and security during this transition is complicated by the diversified spectrum of threat 'players' that has greatly impacted nonproliferation, counterterrorism, and homeland security requirements. Rogue states and non-state actors no longer need self-contained national nuclear expertise, materials, and equipment due to availability from various sources in the nuclear market, thereby reducing the time, effort and cost for acquiring a nuclear weapon (i.e., manifestations of latency). The terrorist threat has changed the nature of military and national security requirements to protect these materials. An Integrated Global Nuclear Materials Management (IGNMM) approach would address the existing legacy nuclear materials and the evolution towards a nuclear energy future, while strengthening a regime to prevent nuclear weapon proliferation. In this paper, some preliminary concepts and studies of IGNMM will be presented. A systematic analysis of nuclear materials, activities, and controls can lead to a tractable, integrated global nuclear materials management architecture that can help remediate the past and manage the future. A systems approach is best suited to achieve multi-dimensional and interdependent solutions, including comprehensive, end-to-end capabilities; coordinated diverse elements for enhanced functionality with economy; and translation of goals/objectives or standards into locally optimized solutions. A risk-informed basis is excellent for evaluating system alternatives and performances, and it is especially appropriate for the security arena. Risk management strategies--such as defense-in-depth, diversity, and control quality--help to weave together various technologies and practices into a strong and robust security fabric. Effective

  9. Global integrability of field theories. Proceedings

    Calmet, J.; Seiler, W.M.; Tucker, R.W.

    2006-01-01

    The GIFT 2006 workshop covers topics related to the Global Integration of Field Theories. These topics span several domains of science including Mathematics, Physics and Computer Science. It is indeed an interdisciplinary event and this feature is well illustrated by the diversity of papers presented at the workshop. Physics is our main target. A simple approach would be to state that we investigate systems of partial differential equations since it is widely believed that they provide a fair description of our world. The questions whether this world is Einsteinian or not, is described by String Theory or not are not however on our agenda. At this stage we have defined what we mean with field theories. To assess what global integrability means we surf on the two other domains of our interest. Mathematics delivers the main methodologies and tools to achieve our goal. It is a trivial remark to say that there exists several approaches to investigate the concept of integrability. Only selected ones are to be found in these proceedings. We do not try to define precisely what global integrability means. Instead, we only suggest two tracks. The first one is by analogy with the design of algorithms, in Computer Algebra or Computer Science, to solve systems of differential equations. The case of ODEs is rather well understood since a constructive methodology exists. Although many experts claim that numerous results do exist to solve systems of PDEs, no constructive decision method exists. This is our first track. The second track follows directly since the real world is described by systems of PDEs, which are mainly non-linear ones. To be able to decide in such a case of the existence of solutions would increase immediately the scope of new technologies applicable to indus trial problems. It is this latter remark that led to the European NEST project with the same name. The GIFT project aims at making progresses in the investigation of field theories through the use of very

  10. Global integrability of field theories. Proceedings

    Calmet, J.; Seiler, W.M.; Tucker, R.W. (eds.)

    2006-07-01

    The GIFT 2006 workshop covers topics related to the Global Integration of Field Theories. These topics span several domains of science including Mathematics, Physics and Computer Science. It is indeed an interdisciplinary event and this feature is well illustrated by the diversity of papers presented at the workshop. Physics is our main target. A simple approach would be to state that we investigate systems of partial differential equations since it is widely believed that they provide a fair description of our world. The questions whether this world is Einsteinian or not, is described by String Theory or not are not however on our agenda. At this stage we have defined what we mean with field theories. To assess what global integrability means we surf on the two other domains of our interest. Mathematics delivers the main methodologies and tools to achieve our goal. It is a trivial remark to say that there exists several approaches to investigate the concept of integrability. Only selected ones are to be found in these proceedings. We do not try to define precisely what global integrability means. Instead, we only suggest two tracks. The first one is by analogy with the design of algorithms, in Computer Algebra or Computer Science, to solve systems of differential equations. The case of ODEs is rather well understood since a constructive methodology exists. Although many experts claim that numerous results do exist to solve systems of PDEs, no constructive decision method exists. This is our first track. The second track follows directly since the real world is described by systems of PDEs, which are mainly non-linear ones. To be able to decide in such a case of the existence of solutions would increase immediately the scope of new technologies applicable to indus trial problems. It is this latter remark that led to the European NEST project with the same name. The GIFT project aims at making progresses in the investigation of field theories through the use of very

  11. Toward an Integrative Model of Global Business Strategy

    Li, Xin

    fragmentation-integration-fragmentation-integration upward spiral. In response to the call for integrative approach to strategic management research, we propose an integrative model of global business strategy that aims at integrating not only strategy and IB but also the different paradigms within the strategy...... field. We also discuss the merit and limitation of our model....

  12. Integrated global digital image correlation for interface delamination characterization

    Hoefnagels, Johan P.M.

    2013-07-23

    Interfacial delamination is a key reliability challenge in composites and micro-electronic systems due to (high-density) integration of dissimilar materials. Predictive finite element models are used to minimize delamination failures during design, but require accurate interface models to capture (irreversible) crack initiation and propagation behavior observed in experiments. Therefore, an Integrated Global Digital Image Correlation (I-GDIC) strategy is developed for accurate determination of mechanical interface behavior from in-situ delamination experiments. Recently, a novel miniature delamination setup was presented that enables in-situ microscopic characterization of interface delamination while sensitively measuring global load-displacement curves for all mode mixities. Nevertheless, extraction of detailed mechanical interface behavior from measured images is challenging, because deformations are tiny and measurement noise large. Therefore, an advanced I-GDIC methodology is developed which correlates the image patterns by only deforming the images using kinematically-admissible \\'eigenmodes\\' that correspond to the few parameters controlling the interface tractions in an analytic description of the crack tip deformation field, thereby greatly enhancing accuracy and robustness. This method is validated on virtual delamination experiments, simulated using a recently developed self-adaptive cohesive zone (CZ) finite element framework. © The Society for Experimental Mechanics, Inc. 2014.

  13. The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

    Firmanzah Firmanzah

    2013-07-01

    Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market. Keywords: new product launching (NPL, coordination mechanism, control mechanism, and new product performance

  14. Mechanical integrity of thin films

    Hoffman, R.W.

    1979-01-01

    Mechanical considerations starting with the initial film deposition including questions of adhesion and grading the interface are reviewed. Growth stresses, limiting thickness, stress relief, control aging, and creep are described

  15. Global Environmental Change: An integrated modelling approach

    Den Elzen, M.

    1993-01-01

    Two major global environmental problems are dealt with: climate change and stratospheric ozone depletion (and their mutual interactions), briefly surveyed in part 1. In Part 2 a brief description of the integrated modelling framework IMAGE 1.6 is given. Some specific parts of the model are described in more detail in other Chapters, e.g. the carbon cycle model, the atmospheric chemistry model, the halocarbon model, and the UV-B impact model. In Part 3 an uncertainty analysis of climate change and stratospheric ozone depletion is presented (Chapter 4). Chapter 5 briefly reviews the social and economic uncertainties implied by future greenhouse gas emissions. Chapters 6 and 7 describe a model and sensitivity analysis pertaining to the scientific uncertainties and/or lacunae in the sources and sinks of methane and carbon dioxide, and their biogeochemical feedback processes. Chapter 8 presents an uncertainty and sensitivity analysis of the carbon cycle model, the halocarbon model, and the IMAGE model 1.6 as a whole. Part 4 presents the risk assessment methodology as applied to the problems of climate change and stratospheric ozone depletion more specifically. In Chapter 10, this methodology is used as a means with which to asses current ozone policy and a wide range of halocarbon policies. Chapter 11 presents and evaluates the simulated globally-averaged temperature and sea level rise (indicators) for the IPCC-1990 and 1992 scenarios, concluding with a Low Risk scenario, which would meet the climate targets. Chapter 12 discusses the impact of sea level rise on the frequency of the Dutch coastal defence system (indicator) for the IPCC-1990 scenarios. Chapter 13 presents projections of mortality rates due to stratospheric ozone depletion based on model simulations employing the UV-B chain model for a number of halocarbon policies. Chapter 14 presents an approach for allocating future emissions of CO 2 among regions. (Abstract Truncated)

  16. Developing a Global Mindset: Integrating Demographics, Sustainability, Technology, and Globalization

    Aggarwal, Raj

    2011-01-01

    Business schools face a number of challenges in responding to the business influences of demographics, sustainability, and technology--all three of which are also the fundamental driving forces for globalization. Demographic forces are creating global imbalances in worker populations and in government finances; the world economy faces…

  17. 40 CFR 68.73 - Mechanical integrity.

    2010-07-01

    ...) CHEMICAL ACCIDENT PREVENTION PROVISIONS Program 3 Prevention Program § 68.73 Mechanical integrity. (a) Application. Paragraphs (b) through (f) of this section apply to the following process equipment: (1) Pressure... shall establish and implement written procedures to maintain the on-going integrity of process equipment...

  18. Feynman path integral formulation of quantum mechanics

    Mizrahi, M.M.

    1975-01-01

    The subject of this investigation is Feynman's path integral quantization scheme, which is a powerful global formalism with great intuitive appeal. It stems from the simple idea that a probability amplitude for a system to make a transition between two states is the ''sum'' of the amplitudes for all the possible ways the transition can take place

  19. The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

    Firmanzah

    2007-10-01

    Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market.

  20. Introduction to solid mechanics an integrated approach

    Lubliner, Jacob

    2014-01-01

    This textbook presents for the first time in one text the concepts and processes covered in statics and mechanics of materials curricula following a systematic, topically integrated approach. Since the turn of the millennium, it has become common in engineering schools to combine the traditional undergraduate offerings in rigid-body statics (usually called “statics”) and deformable body mechanics (known traditionally as “strength of materials” or, more recently, “mechanics of materials”) into a single, introductory course in solid mechanics. Many textbooks for the new course sequentially meld pieces of existing, discrete books—sometimes, but not always, acknowledging the origin—into two halves covering Statics and Mechanics of Materials. In this volume, Professors Lubliner and Papadopoulos methodically combine the essentials of statics and mechanics of materials, illustrating the relationship of concepts throughout, into one "integrated" text. This book also: ·         Offers thorough...

  1. Global integrability of cosmological scalar fields

    Maciejewski, Andrzej J.; Przybylska, Maria; Stachowiak, Tomasz; Szydłowski, Marek

    2008-11-01

    We investigate the Liouvillian integrability of Hamiltonian systems describing a universe filled with a scalar field (possibly complex). The tool used is the differential Galois group approach, as introduced by Morales-Ruiz and Ramis. The main result is that the generic systems with minimal coupling are non-integrable, although there still exist some values of parameters for which integrability remains undecided; the conformally coupled systems are only integrable in four known cases. We also draw a connection with the chaos present in such cosmological models, and the issues of the integrability restricted to the real domain.

  2. Global integrability of cosmological scalar fields

    Maciejewski, Andrzej J; Przybylska, Maria; Stachowiak, Tomasz; Szydlowski, Marek

    2008-01-01

    We investigate the Liouvillian integrability of Hamiltonian systems describing a universe filled with a scalar field (possibly complex). The tool used is the differential Galois group approach, as introduced by Morales-Ruiz and Ramis. The main result is that the generic systems with minimal coupling are non-integrable, although there still exist some values of parameters for which integrability remains undecided; the conformally coupled systems are only integrable in four known cases. We also draw a connection with the chaos present in such cosmological models, and the issues of the integrability restricted to the real domain

  3. Explicit integration of some integrable systems of classical mechanics

    Basak Gancheva, Inna

    2011-01-01

    The main objective of the thesis is the analytical and geometrical study of several integrable finite-dimentional dynamical systems of classical mechanics, which are closely related, namely: - the classical generalization of the Euler top: the Zhukovski-Volterra (ZV) system describing the free motion of a gyrostat, i.e., a rigid body carrying a symmetric rotator whose axis is fixed in the body; - the Steklov-Lyapunov integrable case of the Kirchhoff equations describing the motio...

  4. Global design of an active integrated antenna for millimeter wave

    Marzolf, Eric; Drissi, M’hamed

    2001-01-01

    An active integrated antenna working in the millimeter wave has been realized in a monolithic process. The concept of active integrated antenna is first introduced, then the design of the integrated circuit based on a global approach, following electromagnetic and circuit simulations, is presented. The obtained performances of the active antenna are discussed and compared to a passive one.

  5. Introduction to solid mechanics an integrated approach

    Lubliner, Jacob

    2017-01-01

    This expanded second edition presents in one text the concepts and processes covered in statics and mechanics of materials curricula following a systematic, topically integrated approach. Building on the novel pedagogy of fusing concepts covered in traditional undergraduate courses in rigid-body statics and deformable body mechanics, rather than simply grafting them together, this new edition develops further the authors’ very original treatment of solid mechanics with additional figures, an elaboration on selected solved problems, and additional text as well as a new subsection on viscoelasticity in response to students’ feedback. Introduction to Solid Mechanics: An Integrated Approach, Second Edition, offers a holistic treatment of the depth and breadth of solid mechanics and the inter-relationships of its underlying concepts. Proceeding from first principles to applications, the book stands as a whole greater than the sum of its parts.  .

  6. A globally integrated climate policy for Canada

    Bernstein, S.; Brunnee, J.; Duff, D.G.; Green, A.J.

    2008-01-01

    This book explored policy ideas and options from various perspectives, including science, law, political science, economics and sociology. The costs, opportunities and imperatives to participate in international diplomatic initiatives were considered along with the opportunities of regional global carbon markets. Canada's current policy on climate change negotiations have been focused on domestic regulation and incentives for technological responses and the setting of a domestic carbon price. The sense of urgency about global warming was discussed and the need for action to respond to the threat of global climate change was emphasized. The book also reviewed Canada's role in international climate policies and presented parameters and imperatives for global regime building in Canada. Domestic policy tools were also reviewed along with policy obstacles and opportunities. refs., tabs., figs.

  7. Integrating Global Poverty into Mainstream Business Classrooms

    Paton, Bruce; Harris-Boundy, Jason; Melhus, Peter

    2012-01-01

    Most of the products and services discussed in business curricula serve a small portion of humanity. But the great majority of economic growth over the next few decades is expected to occur in emerging and frontier markets. This emerging reality increases the urgency for including topics related to global poverty, unmet human needs, and emergence…

  8. Functional integral in supersymmetric quantum mechanics

    Ktitarev, D.V.

    1990-01-01

    The solution of the square root of the Schroedinger equation for the supersymmetric quantum mechanics is expressed in the form of series. The formula may be considered as a functional integral of the chronological exponent of the super-pseudodifferential operator symbol over the superspace. 10 refs

  9. The real mechanisms of the global economy

    Angel Asensio

    2010-12-01

    Full Text Available The paper presents the main arguments of Bresser Pereira's Globalization and Competition. Development strategies based on the 'conventional orthodoxy' are shown to carry serious drawbacks ("Dutch disease", pernicious effects of external saving, currency overvaluation, while a 'new developmentalism' is promoted, in spite of the widespread belief that the nation-states have been dispossessed of their room for manoeuvre because of the globalization process. The "new developmentalism" is based on domestic finance, balanced public budgets, moderate interest rates and competitiveness policies aimed at neutralizing the tendency to exchange rate overappreciation. The paper also points out a few theoretical questions the book raises.

  10. Global challenges in integrated coastal zone management

    integration of data and information in policy and management, combining expertise from nature and social science, to reach a balanced and sustainable development of the coastal zone. This important book comprises the proceedings of The International Symposium on Integrated Coastal Zone Management, which took....../mitigation to change in coastal systems Coastal governance Linking science and management Comprising a huge wealth of information, this timely and well-edited volume is essential reading for all those involved in coastal zone management around the globe. All libraries in research establishments and universities where...

  11. two strategies to be integrated into globalization

    Alvarado, Fernando

    2011-01-01

    The present thesis work intends to investigate internal and external factors determining the type of strategy of foreign policy used by Argentina and Chile in order to be part of globalization. In both cases, it is a strategy where the emphasis on the management of foreign policy, more economic than political, prevails. However, under the same external context and similar formal institutional frameworks, the main difference of both strategies may be found in the conceptual approach, which is ...

  12. Payment Mechanisms for Integrated Teams in Construction

    Ibrahim Motawa

    2012-11-01

    Full Text Available The overwhelming consensus for process andteam integration has emerged as an enabler tomanage construction projects. Theperformance of integrated teams is highlyaffected by the adopted payment mechanism.However, the payment mechanisms availablefor a project may need the team tocompromise in order to agree on a fairmechanism for as many members as possible.This paper introduces a methodology tosimulate the profiles of alternative paymentmechanisms. The methodology aims to helpproject teams define the most appropriatemechanism for each member. The proposedmethodology is therefore novel and superior toexisting cash flow models where the focus hasbeen limited to main contractors only. Topromote its use as a performance enablingmechanism, the methodology utilizes “theproject process map”, “the stakeholders &supply chain”, “the pricing method” and “thepayment mechanism”. This will act as an aid todesign or “fine-tune” payment mechanisms toindividual projects characteristics consideringpayment for off-site materials andcomponents, which always concerns projectfabricators and supply chain.

  13. Integrating Curriculum: A Case Study of Teaching Global Education

    Ferguson-Patrick, Kate; Reynolds, Ruth; Macqueen, Suzanne

    2018-01-01

    Despite widespread support for integrated approaches to teaching, classroom practice reveals a lack of implementation. This paper explores challenges and opportunities in teaching an integrated curriculum, and connects this with the contemporary notion of a twenty-first century curriculum and pedagogy. A case study of Global Education (GE) is used…

  14. Development of an Integrated Global Energy Model

    Krakowski, R.A.

    1999-01-01

    The primary objective of this research was to develop a forefront analysis tool for application to enhance understanding of long-term, global, nuclear-energy and nuclear-material futures. To this end, an existing economics-energy-environmental (E 3 ) model was adopted, modified, and elaborated to examine this problem in a multi-regional (13), long-term (approximately2,100) context. The E 3 model so developed was applied to create a Los Alamos presence in this E 3 area through ''niche analyses'' that provide input to the formulation of policies dealing with and shaping of nuclear-energy and nuclear-materials futures. Results from analyses using the E 3 model have been presented at a variety of national and international conferences and workshops. Through use of the E 3 model Los Alamos was afforded the opportunity to participate in a multi-national E 3 study team that is examining a range of global, long-term nuclear issues under the auspices of the IAEA during the 1998-99 period . Finally, the E 3 model developed under this LDRD project is being used as an important component in more recent Nuclear Material Management Systems (NMMS) project

  15. The Integrative Dimension of the Economic Globalization in European Space

    Daniela Mariana Alexandrache

    2010-06-01

    Full Text Available We believe that globalization and its socio-economic implications of the world and world economic crisis is one of the most debated issues from several years. The publication "The Economist’’ named globalization as the most used word of the century. The most relevant dimension of globalization is the economy with the more dynamic factors: technological development, the hegemony of liberal conceptions (closely linked to the triumph of the ideology of market economy and explosive development of countries or regions. Economic globalization has manifested a series of visible effects such as: the emergence of new markets and foreign trade (interconnected at global level, the appearance of: transnational companies, multilateral agreements on trade, broadening the scope of WTO, transformation of multinational companies in transnational companies and the emergence of global economic markets. Regionally, we noticed that the trendof concentration of economic activity is more pronounced and advanced in the European continent. Expanding globalization in Europe was achieved because of the fall of communism, and the neoliberal reformation which took place in Western European countries. Events like the fall of the Berlin Wall, followed by the fall of communism eradicated many political, economic, religious or cultural barriers. There were born new relations between state and market, public and private. European Union is, in our view, a regional office ofglobalization, representing the best performing integrative system in the world (by creating free trade area, customs union, common market, the Economic and Monetary Union. In terms of the European Commission,European model is a third way towards globalization, a middle path between protectionism and uncontrolled economy. To understand why the EU is an advanced approximation of globalization, perhaps a regional model of globalization, we must first understand the link between globalization and regional

  16. Global integration of European tuna markets

    Jiménez-Toribio, Ramòn; Guillotreau, Patrice; Mongruel, Rémi

    2010-07-01

    This paper evaluates the degree of integration between the world market and the major European marketplaces of frozen and canned tuna through both vertical and horizontal price relationships. Spatial linkages are investigated horizontally in order to estimate the connection between the European market and the world-wide market on the primary stage of the value chain. One of the key results is the high level of market integration at the ex-vessel stage, and the price leadership of yellowfin tuna over skipjack tuna. The same approach is applied at the ex-factory level. Basically, the European market for final goods appears to be segmented between the Northern countries consuming low-priced canned skipjack tuna imported from Asia (mainly Thailand) and the Southern countries (Italy, Spain) processing and importing yellowfin-based products sold at higher prices. France appears to be an intermediate market where both products are consumed. The former market is found to be well integrated to the world market and can be considered to be competitive, but there is a suspicion of market power being exercised on the latter. Price relationships are therefore tested vertically between the price of frozen tuna paid by the canneries and the price of canned fish in both Italy and France. The two species show an opposite pattern in prices transmission along the value chain: price changes along the chain are far better transmitted for the “global” skipjack tuna than for the more “European” yellowfin tuna. The results are discussed, along with their implications for the fishing industry.

  17. Global integration strategies in times of crisis

    Jensen, Camilla

    2017-01-01

    In recent years, we can observe the emergence of firms, born both digital and global, that have disrupted existing industries. Deploying digital technologies, they have developed innovative value chains and business models that threaten established multinational companies (MNCs). In this chapter......, we examine how MNCs can and do respond to the challenge digital technologies represent. We describe the main facets of digital technologies and discus the potential these have to undermine the value chains and business models of established MNCs. In order to illustrate this, we employ longitudinal...... data from Telenor, a leading multinational mobile telecom company. Telenor perceives digitalization as a critical threat that in turn is causing a radical rethink about the viability of its decentralized, locally responsive value chain and business model. Our data provides insights into business models...

  18. Mechanical systems development of integral reactor

    Park, Keun Bae; Chang, M. H.; Kim, J. I.; Choi, S.; Kim, K. S.; Kim, T. W.; Jeong, K. H.; Kim, J. H.; Kim, Y. W.; Lee, G. M.

    1997-07-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose applications such as small capacity power generation, co-generation and sea water desalination. This in mind, survey has been made on the worldwide small and medium integral reactors under development. Reviewed are their technical characteristics, development status, design features, application plans, etc. For the mechanical design scope of work, the structural concept compatible with the characteristics and requirements of integral reactor has been established. Types of major components were evaluated and selected. Functional and structural concept, equipment layout and supporting concept within the reactor pressure vessel have also been established. Preliminary mechanical design requirements were developed considering the reactor lifetime, operation conditions, and the expected loading combinations. To embody the concurrent design approach, recent CAD technology and team engineering concept were evaluated. (author). 31 refs.,16 tabs., 35 figs

  19. Integration of fracture mechanics and NDE

    Njo, D.H.; McDonald, N.R.; Nichols, R.W.

    1991-01-01

    This paper addresses issues concerning the effective assessment of the structural integrity of safety related components, principally the primary system, in operating nuclear power plants. The failure mode of greatest safety concern is fracture and this is usually assessed by fracture mechanics (FM) procedures. These require the choice and application of an appropriate analytical method based on a knowledge of the materials, loading and environmental conditions, and characteristics of such defects as have been identified by non destructive examination (NDE). The paper focuses on capabilities and limitations of the NDE procedures, FM methods and other input information which must be taken into account in practical circumstances as well as some problems encountered. It concludes that an integral approach requiring mutual understanding, dialogue and cooperation among the materials, FM and NDE experts is essential for effective and reliable structural integrity assessments

  20. Rethinking global health research: towards integrative expertise

    MacLachlan Malcolm

    2009-07-01

    Full Text Available Abstract The Bamako Call for Action on Research for Health stresses the importance of inter-disciplinary, inter-ministerial and inter-sectoral working. This challenges much of our current research and postgraduate research training in health, which mostly seeks to produce narrowly focused content specialists. We now need to compliment this type of research and research training, by offering alternative pathways that seek to create expertise, not only in specific narrow content areas, but also in the process and context of research, as well as in the interaction of these different facets of knowledge. Such an approach, developing 'integrative expertise', could greatly facilitate better research utilisation, helping policy makers and practitioners work through more evidence-based practice and across traditional research boundaries.

  1. RELEVANT PROBLEMS OF UKRAINE’S INTEGRATION INTO GLOBAL ECONOMY

    Yevheniia Duliba

    2017-12-01

    Full Text Available The purpose of this research is to study the main problems that prevent Ukraine from integrating into the global economy and to determine correct focuses of the foreign economic policy of Ukraine against the background of strengthening of globalization tendencies throughout the world. The bases of this research are bases of business development of the foreign economic policy of Ukraine and improvement of Ukrainian economy against the background of international integration. At the heart of the research methodology is a dialectical method of scientific knowledge and, besides, special methods of research based on modern scientific bases of economic, management and related to them knowledge: economic and statistic method – for the assessment of the modern state of foreign trade and investment activity of Ukraine; method of analysis and synthesis – for the determination of tendencies of development of integration processed in Ukraine; comparative analysis – for comparison of information concerning development of specific indicators of foreign economic activities in Ukraine. Results. As a result of research, the main blocks of problems, which impede the integration of Ukraine into the global economy, and requirements for their complex solution are determined. Besides, interdependence and interdetermination of problems, which impede the integration of Ukraine into the global economy, and requirements for their complex solution are explained. Political and legal, economic, sociocultural, and infrastructural preconditions that are necessary for effective integration of Ukraine into the global economy are highlighted. Practical implications. Analysis of the existing problems related to the actual economy, investments, innovation processes gives the possibility to determine the vector of development of Ukraine’s economy taking to account recommendations concerning its improvement for the purposes of integration into global economy. Value

  2. The formal path integral and quantum mechanics

    Johnson-Freyd, Theo

    2010-01-01

    Given an arbitrary Lagrangian function on R d and a choice of classical path, one can try to define Feynman's path integral supported near the classical path as a formal power series parameterized by 'Feynman diagrams', although these diagrams may diverge. We compute this expansion and show that it is (formally, if there are ultraviolet divergences) invariant under volume-preserving changes of coordinates. We prove that if the ultraviolet divergences cancel at each order, then our formal path integral satisfies a 'Fubini theorem' expressing the standard composition law for the time evolution operator in quantum mechanics. Moreover, we show that when the Lagrangian is inhomogeneous quadratic in velocity such that its homogeneous-quadratic part is given by a matrix with constant determinant, then the divergences cancel at each order. Thus, by 'cutting and pasting' and choosing volume-compatible local coordinates, our construction defines a Feynman-diagrammatic 'formal path integral' for the nonrelativistic quantum mechanics of a charged particle moving in a Riemannian manifold with an external electromagnetic field.

  3. Integrating scientific, economic, and ecological aspects of global change

    Jacoby, H.D.; Yang, Z.

    1994-01-01

    The MIT Joint Program on the Science and Policy of Global Change is conducting research on methods for integrating the science of potential global change with economic analysis of litigation policies and quantification of economic and environmental impacts. The paper describes this work, with a focus on the way that research within the various contributing disciplines, and the design of their associated models, are influenced by the process of inclusion in an integrated framework for policy analysis. The results should contribute new insight into the relative importance of key feedbacks within the economy-climate-ecology system

  4. An integrated artificial neural networks approach for predicting global radiation

    Azadeh, A.; Maghsoudi, A.; Sohrabkhani, S.

    2009-01-01

    This article presents an integrated artificial neural network (ANN) approach for predicting solar global radiation by climatological variables. The integrated ANN trains and tests data with multi layer perceptron (MLP) approach which has the lowest mean absolute percentage error (MAPE). The proposed approach is particularly useful for locations where no available measurement equipment. Also, it considers all related climatological and meteorological parameters as input variables. To show the applicability and superiority of the integrated ANN approach, monthly data were collected for 6 years (1995-2000) in six nominal cities in Iran. Separate model for each city is considered and the quantity of solar global radiation in each city is calculated. Furthermore an integrated ANN model has been introduced for prediction of solar global radiation. The acquired results of the integrated model have shown high accuracy of about 94%. The results of the integrated model have been compared with traditional angstrom's model to show its considerable accuracy. Therefore, the proposed approach can be used as an efficient tool for prediction of solar radiation in the remote and rural locations with no direct measurement equipment.

  5. Hidden symmetries of integrable conformal mechanical systems

    Hakobyan, Tigran; Krivonos, Sergey; Lechtenfeld, Olaf; Nersessian, Armen

    2010-01-01

    We split the generic conformal mechanical system into a 'radial' and an 'angular' part, where the latter is defined as the Hamiltonian system on the orbit of the conformal group, with the Casimir function in the role of the Hamiltonian. We reduce the analysis of the constants of motion of the full system to the study of certain differential equations on this orbit. For integrable mechanical systems, the conformal invariance renders them superintegrable, yielding an additional series of conserved quantities originally found by Wojciechowski in the rational Calogero model. Finally, we show that, starting from any N=4 supersymmetric 'angular' Hamiltonian system one may construct a new system with full N=4 superconformal D(1,2;α) symmetry.

  6. Thermal integrity in mechanics and engineering

    Shorr, Boris F

    2015-01-01

    The book is targeted at engineers, university lecturers, postgraduates, and final year undergraduate students involved in computational modelling and experimental and theoretical analysis of the high-temperature behavior of engineering structures. It will also be of interest to researchers developing the thermal strength theory as a branch of continuum mechanics. Thermal integrity is a multidisciplinary field combining the expertise of mechanical engineers, material scientists and applied mathematicians, each approaching the problem from their specific viewpoint. This monograph draws on the research of a broad scientific community including the author’s contribution. The scope of thermal strength analysis was considerably extended thanks to modern computers and the implementation of FEM codes. However, the author believes that some material models adopted in the advanced high-performance software, are not sufficiently justificated due to lack of easy-to-follow books on the theoretical and experimental aspec...

  7. Thermal integrity in mechanics and engineering

    Shorr, Boris F.

    2015-01-01

    The book is targeted at engineers, university lecturers, postgraduates, and final year undergraduate students involved in computational modelling and experimental and theoretical analysis of the high-temperature behavior of engineering structures. It will also be of interest to researchers developing the thermal strength theory as a branch of continuum mechanics. Thermal integrity is a multidisciplinary field combining the expertise of mechanical engineers, material scientists and applied mathematicians, each approaching the problem from their specific viewpoint. This monograph draws on the research of a broad scientific community including the author's contribution. The scope of thermal strength analysis was considerably extended thanks to modern computers and the implementation of FEM codes. However, the author believes that some material models adopted in the advanced high-performance software, are not sufficiently justificated due to lack of easy-to-follow books on the theoretical and experimental aspects of thermal integrity. The author endeavors to provide a thorough yet sufficiently simple presentation of the underlying concepts, making the book compelling to a wide audience.

  8. Thermal integrity in mechanics and engineering

    Shorr, Boris F. [Central Institute of Aviation Motors (CIAM), Moscow (Russian Federation)

    2015-07-01

    The book is targeted at engineers, university lecturers, postgraduates, and final year undergraduate students involved in computational modelling and experimental and theoretical analysis of the high-temperature behavior of engineering structures. It will also be of interest to researchers developing the thermal strength theory as a branch of continuum mechanics. Thermal integrity is a multidisciplinary field combining the expertise of mechanical engineers, material scientists and applied mathematicians, each approaching the problem from their specific viewpoint. This monograph draws on the research of a broad scientific community including the author's contribution. The scope of thermal strength analysis was considerably extended thanks to modern computers and the implementation of FEM codes. However, the author believes that some material models adopted in the advanced high-performance software, are not sufficiently justificated due to lack of easy-to-follow books on the theoretical and experimental aspects of thermal integrity. The author endeavors to provide a thorough yet sufficiently simple presentation of the underlying concepts, making the book compelling to a wide audience.

  9. Simulation analysis of globally integrated logistics and recycling strategies

    Song, S.J.; Hiroshi, K. [Hiroshima Inst. of Tech., Graduate School of Mechanical Systems Engineering, Dept. of In formation and Intelligent Systems Engineering, Hiroshima (Japan)

    2004-07-01

    This paper focuses on the optimal analysis of world-wide recycling activities associated with managing the logistics and production activities in global manufacturing whose activities stretch across national boundaries. Globally integrated logistics and recycling strategies consist of the home country and two free trading economic blocs, NAFTA and ASEAN, where significant differences are found in production and disassembly cost, tax rates, local content rules and regulations. Moreover an optimal analysis of globally integrated value-chain was developed by applying simulation optimization technique as a decision-making tool. The simulation model was developed and analyzed by using ProModel packages, and the results help to identify some of the appropriate conditions required to make well-performed logistics and recycling plans in world-wide collaborated manufacturing environment. (orig.)

  10. Systems Approaches: A Global and Historical Perspective on Integrative Medicine

    2012-01-01

    The globalization of healing systems is a dance of cultural awareness and cultural dominance that has arisen throughout history. With the development of greater communication and interest in whole-systems approaches to healing, the opportunity for the development of a global perspective on healing has emerged with new life force. The birth of integrative holistic healing systems in the West, such as naturopathic, homeopathic, anthroposophic, integral and functional medicine, and others, echoes the ocean of wisdom present in traditional healing systems, such as traditional Chinese medicine (TCM) and Ayurveda. In working to integrate the lessons from these systems, we see the inextricable link between man and the natural world, we work to understand the root cause of disease, we focus on the whole person to return balance, and we use empiric observation in large populations over time to grasp the interrelationships inherent in the whole-systems view of illness and wellness. PMID:24278794

  11. Nonbinding Legal Instruments in Governance for Global Health: Lessons from the Global AIDS Reporting Mechanism.

    Taylor, Allyn; Alfvén, Tobias; Hougendobler, Daniel; Buse, Kent

    2014-01-01

    Recent debate over World Health Organization reform has included unprecedented attention to international lawmaking as a future priority function of the Organization. However, the debate is largely focused on the codification of new binding legal instruments. Drawing upon lessons from the success of the Global AIDS Reporting Mechanism, established pursuant to the United Nations' Declaration of Commitment on HIV/AIDS, we argue that effective global health governance requires consideration of a broad range of instruments, both binding and nonbinding. A detailed examination of the Global AIDS Reporting Mechanism reveals that the choice of the nonbinding format makes an important contribution to its effectiveness. For instance, the flexibility and adaptability of the nonbinding format have allowed the global community to: (1) undertake commitments in a timely manner; (2) adapt and experiment in the face of a dynamic pandemic; and (3) grant civil society an unparalleled role in monitoring and reporting on state implementation of global commitments. UNAIDS' institutional support has also played a vital role in ensuring the continuing effectiveness of the Global AIDS Reporting Mechanism. Overall, the experience of the Global AIDS Reporting Mechanism evidences that, at times, nimbler nonbinding instruments can offer benefits over slower, more rigid binding legal approaches to governance, but depend critically, like all instruments, on the perceived legitimacy thereof. © 2014 American Society of Law, Medicine & Ethics, Inc.

  12. Global Mechanisms for Sustaining and Enhancing PES Schemes

    Farley, Josh; Aquino, Andre; Daniels, Amy; Moulaert, Azur; Lee, Dan; Krause, Abby

    2010-01-01

    An international payment for ecosystem service (IPES) schemes may be one of the only mechanisms available to stimulate the provision of vital non-marketed ecosystem services at the global level, as those nations that benefit from global ecosystem services (GES) cannot readily force other sovereign nations to provide them. Currently, international trade offers trillions of dollars in incentives for countries to convert natural capital into marketable goods and services, and few payments to ent...

  13. Global and local aspects of causality in quantum mechanics

    Stoica Cristinel

    2013-09-01

    Full Text Available Quantum mechanics forces us to reconsider certain aspects of classical causality. The ‘central mystery’ of quantum mechanics manifests in different ways, depending on the interpretation. This mystery can be formulated as the possibility of selecting part of the initial conditions of the Universe ‘retroactively’. This talk aims to show that there is a global, timeless, ‘bird’s view’ of the spacetime, which makes this mystery more reasonable. We will review some well-known quantum effects from the perspective of global consistency.

  14. DESI focal plate mechanical integration and cooling

    Lambert, A. R.; Besuner, R. W.; Claybaugh, T. M.; Silber, J. H.

    2016-08-01

    The Dark Energy Spectroscopic Instrument (DESI) is under construction to measure the expansion history of the Universe using the Baryon Acoustic Oscillation technique[1]. The spectra of 40 million galaxies over 14000 sq. deg will be measured during the life of the experiment. A new prime focus corrector for the KPNO Mayall telescope will deliver light to 5000 fiber optic positioners. The fibers in turn feed ten broad-band spectrographs. This paper describes the mechanical integration of the DESI focal plate and the thermal system design. The DESI focal plate is comprised of ten identical petal assemblies. Each petal contains 500 robotic fiber positioners. Each petal is a complete, self-contained unit, independent from the others, with integrated power supply, controllers, fiber routing, and cooling services. The major advantages of this scheme are: (1) supports installation and removal of complete petal assemblies in-situ, without disturbing the others, (2) component production, assembly stations, and test procedures are repeated and parallelizable, (3) a complete, full-scale prototype can be built and tested at an early date, (4) each production petal can be surveyed and tested as a complete unit, prior to integration, from the fiber tip at the focal surface to the fiber slit at the spectrograph. The ten petal assemblies will be installed in a single integration ring, which is mounted to the DESI corrector. The aluminum integration ring attaches to the steel corrector barrel via a flexured steel adapter, isolating the focal plate from differential thermal expansions. The plate scale will be kept stable by conductive cooling of the petal assembly. The guider and wavefront sensors (one per petal) will be convectively cooled by forced flow of air. Heat will be removed from the system at ten liquid-cooled cold plates, one per petal, operating at ambient temperature. The entire focal plate structure is enclosed in an insulating shroud, which serves as a thermal barrier

  15. Thermodynamics and statistical mechanics an integrated approach

    Shell, M Scott

    2015-01-01

    Learn classical thermodynamics alongside statistical mechanics with this fresh approach to the subjects. Molecular and macroscopic principles are explained in an integrated, side-by-side manner to give students a deep, intuitive understanding of thermodynamics and equip them to tackle future research topics that focus on the nanoscale. Entropy is introduced from the get-go, providing a clear explanation of how the classical laws connect to the molecular principles, and closing the gap between the atomic world and thermodynamics. Notation is streamlined throughout, with a focus on general concepts and simple models, for building basic physical intuition and gaining confidence in problem analysis and model development. Well over 400 guided end-of-chapter problems are included, addressing conceptual, fundamental, and applied skill sets. Numerous worked examples are also provided together with handy shaded boxes to emphasize key concepts, making this the complete teaching package for students in chemical engineer...

  16. Coordination and Integration of Global Ocean Observing through JCOMM

    Legler, D. M.; Meldrum, D. T.; Hill, K. L.; Charpentier, E.

    2016-02-01

    The primary objective of the JCOMM Observations Coordination Group (OCG) is to provide technical coordination to implement fully integrated ocean observing system across the entire marine meteorology and oceanographic community. JCOMM OCG works in partnership with the Global Ocean Observing System, , which focusses on setting observing system requirements and conducting evalutions. JCOMM OCG initially focused on major global observing networks (e.g. Argo profiling floats, moored buoys, ship based observations, sea level stations, reference sites, etc), and is now expanding its horizon in recognition of new observing needs and new technologies/networks (e.g. ocean gliders). Over the next five years the JCOMM OCG is focusing its attention on integration and coordination in four major areas: observing network implementation particularly in response to integrated ocean observing requirements; observing system monitoring and metrics; standards and best practices; and improving integrated data management and access. This presentation will describe the scope and mission of JCOMM OCG; summarize the state of the global ocean observing system; highlight recent successes and resources for the research, prediction, and assessment communities; summarize our plans for the next several years; and suggest engagement opportunities.

  17. Collaboration in Global Software Engineering Based on Process Description Integration

    Klein, Harald; Rausch, Andreas; Fischer, Edward

    Globalization is one of the big trends in software development. Development projects need a variety of different resources with appropriate expert knowledge to be successful. More and more of these resources are nowadays obtained from specialized organizations and countries all over the world, varying in development approaches, processes, and culture. As seen with early outsourcing attempts, collaboration may fail due to these differences. Hence, the major challenge in global software engineering is to streamline collaborating organizations towards a successful conjoint development. Based on typical collaboration scenarios, this paper presents a structured approach to integrate processes in a comprehensible way.

  18. Global asymptotic stability of density dependent integral population projection models.

    Rebarber, Richard; Tenhumberg, Brigitte; Townley, Stuart

    2012-02-01

    Many stage-structured density dependent populations with a continuum of stages can be naturally modeled using nonlinear integral projection models. In this paper, we study a trichotomy of global stability result for a class of density dependent systems which include a Platte thistle model. Specifically, we identify those systems parameters for which zero is globally asymptotically stable, parameters for which there is a positive asymptotically stable equilibrium, and parameters for which there is no asymptotically stable equilibrium. Copyright © 2011 Elsevier Inc. All rights reserved.

  19. Mechanical Integrity of Canisters Using a Fracture Mechanics Approach

    Koyama, Tomofumi; Guoxiang Zhang; Lanru Jing [Royal Inst. of Technology, Stockholm (Sweden). Dept. of Land and Water Resources Engineering

    2006-07-15

    This report presents the methods and results of a research project about numerical modeling of mechanical integrity of cast-iron canisters for the final disposal of spent nuclear fuel in Sweden, using combined boundary element (BEM) and finite element (FEM) methods. The objectives of the project are: 1) to investigate the possibility of initiation and growth of fractures in the cast-iron canisters under the mechanical loading conditions defined in the premises of canister design by Swedish Nuclear Fuel and Waste Management Co. (SKB); 2) to investigate the maximum bearing capacity of the cast iron canisters under uniformly distributed and gradually increasing boundary pressure until plastic failure. Achievement of the two objectives may provide some quantitative evidence for the mechanical integrity and overall safety of the cast-iron canisters that are needed for the final safety assessment of the geological repository of the radioactive waste repository in Sweden. The geometrical dimension, distribution and magnitudes of loads and Material properties of the canisters and possible fractures were provided by the latest investigations of SKB. The results of the BEM simulations, using the commercial code BEASY, indicate that under the currently defined loading conditions the possibility of initiation of new fractures or growth of existing fractures (defects) are very small, due to the reasons that: 1) the canisters are under mainly compressive stresses; 2) the induced tensile stress regions are too small in both dimension and magnitude to create new fractures or to induce growth of existing fractures, besides the fact that the toughness of the fractures in the cast iron canisters are much higher that the stress intensity factors in the fracture tips. The results of the FEM simulation show a approximately 75 MPa maximum pressure beyond which plastic collapse of the cast-iron canisters may occur, using an elastoplastic Material model. This figure is smaller compared

  20. Integrative modelling reveals mechanisms linking productivity and plant species richness.

    Grace, James B; Anderson, T Michael; Seabloom, Eric W; Borer, Elizabeth T; Adler, Peter B; Harpole, W Stanley; Hautier, Yann; Hillebrand, Helmut; Lind, Eric M; Pärtel, Meelis; Bakker, Jonathan D; Buckley, Yvonne M; Crawley, Michael J; Damschen, Ellen I; Davies, Kendi F; Fay, Philip A; Firn, Jennifer; Gruner, Daniel S; Hector, Andy; Knops, Johannes M H; MacDougall, Andrew S; Melbourne, Brett A; Morgan, John W; Orrock, John L; Prober, Suzanne M; Smith, Melinda D

    2016-01-21

    How ecosystem productivity and species richness are interrelated is one of the most debated subjects in the history of ecology. Decades of intensive study have yet to discern the actual mechanisms behind observed global patterns. Here, by integrating the predictions from multiple theories into a single model and using data from 1,126 grassland plots spanning five continents, we detect the clear signals of numerous underlying mechanisms linking productivity and richness. We find that an integrative model has substantially higher explanatory power than traditional bivariate analyses. In addition, the specific results unveil several surprising findings that conflict with classical models. These include the isolation of a strong and consistent enhancement of productivity by richness, an effect in striking contrast with superficial data patterns. Also revealed is a consistent importance of competition across the full range of productivity values, in direct conflict with some (but not all) proposed models. The promotion of local richness by macroecological gradients in climatic favourability, generally seen as a competing hypothesis, is also found to be important in our analysis. The results demonstrate that an integrative modelling approach leads to a major advance in our ability to discern the underlying processes operating in ecological systems.

  1. Energy integration: Regional economic integration lever and possible insertion factor in the global economy

    Lokolo, M.C.

    2001-01-01

    In the 1920s, just after the War, an idea began taking root in the Old Continent, to build what could be described as the United States of Europe. Thirty years later, in 1951, a new source of energy, coal, paved the way for the economic integration of Europe. It culminated into monetary integration in January 2002. Economic integration makes sense in the context of the relatively small size of some national economies and markets, and the judicious utilization of rare resources and their unequal distribution. In this document, the author elaborated on the principles at play in economic integration and argued that the integration of the national energy markets could be the lever for economic integration through the gradual elimination of the various obstacles to trade. The author first presented a brief historical overview of economic integration from the perspective of global economic relationships, covering the period between the two world wars to the General Agreement on Tariffs and Trade (GATT) to the World Trade Organization (WTO). The concept and the forms of economic integration were reviewed. Energy integration as a lever of regional economic integration and as a factor in global economic insertion were discussed. Energy integration is a tool for the improvement of the human condition. 15 refs

  2. Priority setting of strategies and mechanisms for limiting global warming

    Lewis, S.J.L.

    1994-01-01

    Scientific communities have reached a consensus that increases of greenhouse gas emission will result in climatic warming and sea level rises despite existing uncertainties. Major uncertainties include the sensitivities of climate changes in terms of timing, magnitude, and scales of regional changes. Socioeconomic uncertainties encompass population and economic growth, changes in technology, future reliance on fossil fuel, and policies compiled to stabilize the global warming. Moreover, increase in world population coupled with limited resources will increase the vulnerability of ecosystems and social systems. Global warming has become an international concern since the destinies of all nations are closely interwoven by this issue and how nations deal with it. Appropriate strategies and mechanisms are need to slow down the buildup of CO 2 and other greenhouse gases. Questionnaires were sent to 150 experts in 30 countries to evaluate such strategies and mechanisms for dealing with global warming, from both the domestic and international perspectives. This paper will focus primarily on strategy selection

  3. Integrating developing country manufacturing industries into global supply chain

    Fasika Bete Georgise

    2014-01-01

    Full Text Available Purpose: Due to globalization of manufacturing activities, the arena of competition and competitiveness advantage is moving from firms towards supply chains and networks. With the recent advancement of information and communication technologies this participation are becoming as common business practice in developed countries firms. Companies were more integrated into the world market for the global nature of the sourcing, manufacturing and distribution. These changes create both challenges and opportunities for the manufacturing industries in developing countries. The objective of this paper is to examine the level of inter-organizational and intra-organizational supply chain integration practices in developing country, Ethiopia.Design/methodology/approach: An industrial questionnaires survey was used to collect the current practices of the manufacturing industries in Ethiopia as an example of the developing countries. Descriptive statistics is primarily used for the analysis.Findings: Results show a low level of supply chain relationship both in intra and inter organizational supply chain integration level among members. Accordingly, such issues require much attention to facilitate a greater integration within the supply chains in the Ethiopian manufacturing industries.Research limitations/implications: The paper focuses on examining the practices of Ethiopian manufacturing industries empirical data. The interpretation of results should be taken with prudence.Originality/Value: The manufacturing industry in developing countries (MIDC has been a part of the global supply chains for long time as a supplier of raw material and manufacturer of primary products. Currently, the MIDC is trying to access the different markets segment of the world even with new products starting from their local market to the complex and dynamic international market. Nevertheless, their supply chains are inefficient and hence, their competitiveness level far from the

  4. 2008 – SOME GLOBAL ISSUES AND THEIR IMPACT ON THE PROSPECTS OF FURTHER EUROPEAN UNION INTEGRATION

    Florin Bonciu

    2008-09-01

    Full Text Available The paper analyzes the implications of some global trends and developments on the prospects of further European Union integration. The transfer of attributes from member states to community institutions is a long term process which confronted numerous set-backs and re-launches. The hypothesis discussed in this paper refers to the fact that current developments in the global arena require fast decision making mechanisms involving very sensitive issues and these developments tend to shift the balance towards member states institutions.

  5. Global and Regional Impacts of the Clean Development Mechanism

    Wang, Shunli; De Groot, H.L.F.; Nijkamp, P.; Verhoef, E.T. [VU University, Amsterdam (Netherlands)

    2009-05-15

    Climate change is a serious concern worldwide. Policy research on climate change in the past decades has largely focused on applied modelling exercises. However, the implications of specific policy strategies such as the clean development mechanism (CDM) for global and regional economic and environmental developments has received relatively little attention. This is partly caused by the complexities of modelling an instrument like CDM. By using and modifying the GTAP-E modelling system (GTAP stands for Global Trade Analysis Project), this paper sets out to trace the combined economic and environmental impacts of CDM policies. Particular emphasis is placed on technology transfer induced by alternative CDM policies. Specific attention is devoted to the possible negative consequences of non-participation of the USA in the global coalition, and the associated distributional impacts world-wide.

  6. Global and Regional Impacts of the Clean Development Mechanism

    Wang, Shunli; De Groot, H.L.F.; Nijkamp, P.; Verhoef, E.T.

    2009-05-01

    Climate change is a serious concern worldwide. Policy research on climate change in the past decades has largely focused on applied modelling exercises. However, the implications of specific policy strategies such as the clean development mechanism (CDM) for global and regional economic and environmental developments has received relatively little attention. This is partly caused by the complexities of modelling an instrument like CDM. By using and modifying the GTAP-E modelling system (GTAP stands for Global Trade Analysis Project), this paper sets out to trace the combined economic and environmental impacts of CDM policies. Particular emphasis is placed on technology transfer induced by alternative CDM policies. Specific attention is devoted to the possible negative consequences of non-participation of the USA in the global coalition, and the associated distributional impacts world-wide.

  7. 76 FR 5834 - International Business Machines Corporation, Global Technology Services Business Unit, Integrated...

    2011-02-02

    ... Machines Corporation, Global Technology Services Business Unit, Integrated Technology Services, Cost and..., applicable to workers of International Business Machines Corporation, Global Technology Services Business... engaged in activities related to support for the Global Technology Services Business Unit. The company...

  8. Indirect Effects of Global Change: From Physiological and Behavioral Mechanisms to Ecological Consequences.

    Gunderson, Alex R; Tsukimura, Brian; Stillman, Jonathon H

    2017-07-01

    A major focus of current ecological research is to understand how global change makes species vulnerable to extirpation. To date, mechanistic ecophysiological analyses of global change vulnerability have focused primarily on the direct effects of changing abiotic conditions on whole-organism physiological traits, such as metabolic rate, locomotor performance, cardiac function, and critical thermal limits. However, species do not live in isolation within their physical environments, and direct effects of climate change are likely to be compounded by indirect effects that result from altered interactions with other species, such as competitors and predators. The Society for Integrative and Comparative Biology 2017 Symposium "Indirect Effects of Global Change: From Physiological and Behavioral Mechanisms to Ecological Consequences" was designed to synthesize multiple approaches to investigating the indirect effects of global change by bringing together researchers that study the indirect effects of global change from multiple perspectives across habitat, type of anthropogenic change, and level of biological organization. Our goal in bringing together researchers from different backgrounds was to foster cross-disciplinary insights into the mechanistic bases and higher-order ecological consequences of indirect effects of global change, and to promote collaboration among fields. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  9. How to solve path integrals in quantum mechanics

    Grosche, C.

    1994-10-01

    A systematic classification of Feynman path integrals in quantum mechanics is presented and a table of solvable path integrals is given which reflects the progress made during the last 15 years, including, of course, the main contributions since the invention of the path integral by Feynman in 1942. An outline of the general theory is given which will serve as a quick reference for solving path integrals. Explicit formulae for the so-called basic path integrals are presented on which our general scheme to classify and calculate path integrals in quantum mechanics is based. (orig.)

  10. Integrable models in classical and quantum mechanics

    Jurco, B.

    1991-01-01

    Integrable systems are investigated, especially the rational and trigonometric Gaudin models. The Gaudin models are diagonalized for the case of classical Lie algebras. Their relation to the other integrable models and to the quantum inverse scattering method is investigated. Applications in quantum optics and plasma physics are discussed. (author). 94 refs

  11. RISK INTEGRATION MECHANISMS AND APPROACHES IN BANKING INDUSTRY

    JIANPING LI; JICHUANG FENG; XIAOLEI SUN; MINGLU LI

    2012-01-01

    Recently, the number of consultative documents and research papers that discuss risk integration has grown considerably. This paper presents a comprehensive review of the work done on risk integration in the banking industry. This survey includes: (1) risk integration methods within regulatory frameworks and the banking industry; (2) challenges of risk integration; (3) risk interaction mechanisms; (4) development of risk integration approaches; (5) risk interaction results: diversification ve...

  12. Improved data for integrated modeling of global environmental change

    Lotze-Campen, Hermann

    2011-12-01

    The assessment of global environmental changes, their impact on human societies, and possible management options requires large-scale, integrated modeling efforts. These models have to link biophysical with socio-economic processes, and they have to take spatial heterogeneity of environmental conditions into account. Land use change and freshwater use are two key research areas where spatial aggregation and the use of regional average numbers may lead to biased results. Useful insights can only be obtained if processes like economic globalization can be consistently linked to local environmental conditions and resource constraints (Lambin and Meyfroidt 2011). Spatially explicit modeling of environmental changes at the global scale has a long tradition in the natural sciences (Woodward et al 1995, Alcamo et al 1996, Leemans et al 1996). Socio-economic models with comparable spatial detail, e.g. on grid-based land use change, are much less common (Heistermann et al 2006), but are increasingly being developed (Popp et al 2011, Schneider et al 2011). Spatially explicit models require spatially explicit input data, which often constrains their development and application at the global scale. The amount and quality of available data on environmental conditions is growing fast—primarily due to improved earth observation methods. Moreover, systematic efforts for collecting and linking these data across sectors are on the way (www.earthobservations.org). This has, among others, also helped to provide consistent databases on different land cover and land use types (Erb et al 2007). However, spatially explicit data on specific anthropogenic driving forces of global environmental change are still scarce—also because these cannot be collected with satellites or other devices. The basic data on socio-economic driving forces, i.e. population density and wealth (measured as gross domestic product per capita), have been prepared for spatially explicit analyses (CIESIN, IFPRI

  13. THE INTEGRATION PROCESS MERCOSUR IN 2007 BY MODEL OF GLOBAL DIMENSION OF REGIONAL INTEGRATION

    André Bechlin

    2013-04-01

    Full Text Available This paper aimed to analyze the advance of the regional integration process in the MERCOSUR (Southern Common Market, using a model developed for Professor Mario Ruiz Estrada, of the College of Economy and Administration of the University of Kuala Lumpur in Malaysia, the GDRI (Global Dimension of Regional Integration Model and that as characteristic has differentiated the use of other variable for analysis, that not specifically of economic origin, derivatives of the evolution of the commerce processes. When inferring and comparing the external performance of the economies that compose the Mercosur, evaluating itself the impacts of the advance of the process of regional and commercial integration, are evidents the inequalities that exist in the block. However, a common evolution is observed, in the direction of intensification of the integration between the economies, mainly after the process of opening lived for the continent, beyond the advance of the integration in the context of the Mercosur, from the decade of 1990. The analyzed data show that, in the generality, these economies are if integrating to the world-wide market, and in parallel, accenting the integration degree enters the members of the block.

  14. Modeling Cancer Metastasis using Global, Quantitative and Integrative Network Biology

    Schoof, Erwin; Erler, Janine

    understanding of molecular processes which are fundamental to tumorigenesis. In Article 1, we propose a novel framework for how cancer mutations can be studied by taking into account their effect at the protein network level. In Article 2, we demonstrate how global, quantitative data on phosphorylation dynamics...... can be generated using MS, and how this can be modeled using a computational framework for deciphering kinase-substrate dynamics. This framework is described in depth in Article 3, and covers the design of KinomeXplorer, which allows the prediction of kinases responsible for modulating observed...... phosphorylation dynamics in a given biological sample. In Chapter III, we move into Integrative Network Biology, where, by combining two fundamental technologies (MS & NGS), we can obtain more in-depth insights into the links between cellular phenotype and genotype. Article 4 describes the proof...

  15. INTEGRATED PRODUCT AND ENTERPRISE DESIGN FOR GLOBAL COMPETITIVENESS

    N.D. Du Preez

    2012-01-01

    Full Text Available This paper presentsan overview of the challenge to integrate product and process life cycles in maintaining global competitiveness of an enterprise and proposes IEKOS as a possible solution . It provides the reader with a framework of two virtual life cycles which create a problem solving matrix for the industrial engineer. In this matrix, bordered by the virtual enterprise life cycle and the virtual product life cycles, the business functions of analyze, design deploy and operate are predominantly functions executed by the, industrial engineer. The different phases of each life cycle serves as a framework to a virtual industrial engineering toolkit providing access to detailed functions, formats, examples and a series of software and other "tools" available to the industrial engineer.
    In conclusion a brief overview is provided of the progress of the IEKOS toolkit which is under development at the department of Industrial Engineering at Stellenbosch University.

  16. Domestic change in the face of European Integration and Globalization

    Lynggaard, Kennet

    2011-01-01

    epistemological concerns within the Europeanization literature, this in-the-making research agenda is also faced with a number of methodological challenges. This article deals with some of the most pressing methodological challenges we face when conducting empirical research and moving towards more comprehensive...... accounts of domestic change. Drawing on methodologies known from comparative politics and discourse analysis, the article argues in favour of three methodological moves: (1) from top-down towards bottom-up methodological set-ups; (2) from counterfactual analysis towards compound temporal comparative......Before the early 2000s, research on Europeanization and globalization developed largely independently of each other. Since then a limited, yet increasing, number of studies have shown an interest in investigating and differentiating between the domestic implications of European integration - known...

  17. Integrating Globality and Locality for Robust Representation Based Classification

    Zheng Zhang

    2014-01-01

    Full Text Available The representation based classification method (RBCM has shown huge potential for face recognition since it first emerged. Linear regression classification (LRC method and collaborative representation classification (CRC method are two well-known RBCMs. LRC and CRC exploit training samples of each class and all the training samples to represent the testing sample, respectively, and subsequently conduct classification on the basis of the representation residual. LRC method can be viewed as a “locality representation” method because it just uses the training samples of each class to represent the testing sample and it cannot embody the effectiveness of the “globality representation.” On the contrary, it seems that CRC method cannot own the benefit of locality of the general RBCM. Thus we propose to integrate CRC and LRC to perform more robust representation based classification. The experimental results on benchmark face databases substantially demonstrate that the proposed method achieves high classification accuracy.

  18. Local and Global Illumination in the Volume Rendering Integral

    Max, N; Chen, M

    2005-10-21

    This article is intended as an update of the major survey by Max [1] on optical models for direct volume rendering. It provides a brief overview of the subject scope covered by [1], and brings recent developments, such as new shadow algorithms and refraction rendering, into the perspective. In particular, we examine three fundamentals aspects of direct volume rendering, namely the volume rendering integral, local illumination models and global illumination models, in a wavelength-independent manner. We review the developments on spectral volume rendering, in which visible light are considered as a form of electromagnetic radiation, optical models are implemented in conjunction with representations of spectral power distribution. This survey can provide a basis for, and encourage, new efforts for developing and using complex illumination models to achieve better realism and perception through optical correctness.

  19. Sugarcane bagasse gasification: Global reaction mechanism of syngas evolution

    Ahmed, I.I.; Gupta, A.K.

    2012-01-01

    Highlights: ► Gasification of sugarcane bagasse has been investigated using a semi batch reactor. ► Global reaction mechanism combining pyrolysis and gasification reactions is presented. ► High flow rates of syngas supported fragmentation and secondary reactions. ► CO flow rate increased at higher heating rates at the expense of CO 2 production. ► At high temperatures merger between pyrolysis and char gasification occurs. -- Abstract: Steam gasification of sugarcane bagasse has been investigated. A semi batch reactor with a fixed amount of sugarcane bagasse sample placed in steady flow of high temperature steam at atmospheric pressure has been used. The gasification of bagasse was examined at reactor and steam temperatures of 800, 900 and 1000 °C. The evolution of syngas flow rate and chemical composition has been monitored. The evolution of chemical composition and total flow rate of the syngas has been used to formulate a global reaction mechanism. The mechanism combines pyrolysis reaction mechanisms from the literature and steam gasification/reforming reactions. Steam gasification steps include steam–hydrocarbons reforming, char gasification and water gas shift reactions. Evidence of fragmentation, secondary ring opening reactions and tertiary reactions resulting in formation of gaseous hydrocarbons is supported by higher flow rates of syngas and hydrogen at high heating rates and high reactor temperatures. Increase in carbon monoxide flow rate at the expense of carbon dioxide flow rate with the increase in reactor temperature has been observed. This increase in the ratio of CO/CO 2 flow rate confirms the production of CO and CO 2 from the competing reaction routes. At 1000 °C gasification a total merging between the pyrolysis step and the char gasification step has been observed. This is attributed to acceleration of char gasification reactions and acceleration of steam–hydrocarbons reforming reactions. These hydrocarbons are the precursors to

  20. Integrated management system - ground for the global performance

    Pereira Filho, Jorge Amorim

    2000-01-01

    Organizations working in the pursuit of a sustainable development must create and continuously update their management systems, in order to achieve harmonic and lasting global results, capable of satisfying partners and clients in short and long terms. Such an improvement can be obtained by integrating preexisting classic management models, applicable to organizations of all types and scales. The implementation of this unique resulting system obeys systematic steps of planning, development, checking and correction, aiming to continuously improve the management. It is in fact a very challenging process because it demands changing people minds, increasing the amount of work and learning of new skills. Though hard-working, such implementation is encouraged both by perceiving the necessity to attain the strategic objectives and by seeing that there are some requisites not yet fully covered by the present system. Finally, this improved management system results in a better global performance, recorded under four angles: financial, increased client satisfaction, better internal processes and continuous learning, driving the organization to be more competitive and successful in the future. (author)

  1. Global mechanisms for sustaining and enhancing PES schemes

    Farley, Josh; Moulaert, Azur; Lee, Dan; Krause, Abby; Aquino, Andre; Daniels, Amy

    2010-01-01

    An international payment for ecosystem service (IPES) schemes may be one of the only mechanisms available to stimulate the provision of vital non-marketed ecosystem services at the global level, as those nations that benefit from global ecosystem services (GES) cannot readily force other sovereign nations to provide them. Currently, international trade offers trillions of dollars in incentives for countries to convert natural capital into marketable goods and services, and few payments to entice countries to conserve natural capital in order to sustain critical non-marketed ecosystem services. We examine the biophysical characteristics of climate change and biodiversity to understand the obstacles to developing effective IPES schemes. We find that none of the existing schemes for providing GES are adequate, given the scale of the problem. A cap and auction scheme for CO 2 emissions among wealthy nations could fund IPES and simultaneously deter carbon emissions. To disburse funds, we should adapt Brazil's ICMS ecologico, and apportion available funds to targeted countries in proportion to how well they meet specific criteria designed to measure the provision of GES. Individual countries can then develop their own policies for increasing provision of these services, ensured of compensation if they do so. Indirect IPES should include funding for freely available technologies that protect or provide GES, such as the low carbon energy alternatives that will be essential for curbing climate change. Markets rely on the price mechanism to generate profits, which rations technology to those who can afford it, reducing adoption rates, innovation and total value. (author)

  2. Trends in Global and Regional Integration by means of Trade

    Iulia Monica Oehler-Șincai

    2014-04-01

    Full Text Available In the present paper we aim to emphasize several aspects of the economic integration realized through the channel of trade, from a double perspective. The first point of view is given by the formal framework, de jure, composed by the multitude of preferential trade agreements, while the second one, de facto, market-driven, is concretized by the global production networks. The first stance is exemplified through the agreements negotiated or concluded by the traditional trade powers, EU, US and Japan. Although, economically, EU is more present in Asia-Pacific than the US, the latter are politically more active and seem to gain ground. The second stance is underlined by means of the Asian integration specificity. East and South-East Asia represents the core of „Factory Asia” and is governed by the activity of the transnational corporations, their investment and cross-border networks, which makes the production process more fragmented and the regional economies more mutually dependent.

  3. Integrating Equality - Globalization, Women's Rights, Son Preference and Human Trafficking

    Cho, Seo-Young

    2011-01-01

    Employing economic and social globalization indicators, we empirically analyze whether globalization affects women’s rights in the economic and social dimensions. Using panel data from 150 countries over the 1981-2008 period, we find that social globalization positively affects both women’s economic and social rights, while the impact of economic globalization disappears when controlling for social globalization. Furthermore, we find that social globalization also reduces ‘son preference’ pro...

  4. The Glory Program: Global Science from a Unique Spacecraft Integration

    Bajpayee Jaya; Durham, Darcie; Ichkawich, Thomas

    2006-01-01

    The Glory program is an Earth and Solar science mission designed to broaden science community knowledge of the environment. The causes and effects of global warming have become a concern in recent years and Glory aims to contribute to the knowledge base of the science community. Glory is designed for two functions: one is solar viewing to monitor the total solar irradiance and the other is observing the Earth s atmosphere for aerosol composition. The former is done with an active cavity radiometer, while the latter is accomplished with an aerosol polarimeter sensor to discern atmospheric particles. The Glory program is managed by NASA Goddard Space Flight Center (GSFC) with Orbital Sciences in Dulles, VA as the prime contractor for the spacecraft bus, mission operations, and ground system. This paper will describe some of the more unique features of the Glory program including the integration and testing of the satellite and instruments as well as the science data processing. The spacecraft integration and test approach requires extensive analysis and additional planning to ensure existing components are successfully functioning with the new Glory components. The science mission data analysis requires development of mission unique processing systems and algorithms. Science data analysis and distribution will utilize our national assets at the Goddard Institute for Space Studies (GISS) and the University of Colorado's Laboratory for Atmospheric and Space Physics (LASP). The Satellite was originally designed and built for the Vegetation Canopy Lidar (VCL) mission, which was terminated in the middle of integration and testing due to payload development issues. The bus was then placed in secure storage in 2001 and removed from an environmentally controlled container in late 2003 to be refurbished to meet the Glory program requirements. Functional testing of all the components was done as a system at the start of the program, very different from a traditional program

  5. THE INTEGRATION OF EDUCATION AND SCIENCE AS A GLOBAL PROBLEM

    Anatoliy I. Rakitov

    2016-09-01

    Full Text Available Introduction: mankind is on the edge of a new techno-technological and socio-economical revolution generated by robotization and automation in all spheres of individual and socio-economical activity. Among numerous conceptions of global development only the conception of the knowledge-based society is the most adequate to contemporary terms. As the higher education and science are the main source of knowledge adequate to contemporary terms then their integration should be investigated. Materials and Methods: the material for this investigation was gathered as from individual experience in science and pedagogical activity of the author which were earlier published in hundreds of articles and fifteen monograph translated in eleven languages, as the materials of Moscow city seminar, the results of which were published in annual “Science of science investigations”. This annual has been editing since 2004 and the author is the editor-in-chief of this edition. Also has been used other sources from different editions. The method of comparative analysis was used. Results: the author put forward the conception of inevitable integration of higher school and research institutions and forming a new structure – science-education consortium. Only such united structure can significantly rise both scientific researchers and higher education. And as a result, it will rise publishing activity and application of scientific researchers in real econ omy, social sphere, technological leadership. Discussion and Conclusions: conception put forward in this article fragmentary has been published by author earlier and initiated discussion in scientific press, which was reflected in home RISC and abroad citation indexes. The author proclaims the inevitability of realization of the suggested by him conception of the utmost integration of science and higher education.

  6. Integrated Decision Support for Global Environmental Change Adaptation

    Kumar, S.; Cantrell, S.; Higgins, G. J.; Marshall, J.; VanWijngaarden, F.

    2011-12-01

    Environmental changes are happening now that has caused concern in many parts of the world; particularly vulnerable are the countries and communities with limited resources and with natural environments that are more susceptible to climate change impacts. Global leaders are concerned about the observed phenomena and events such as Amazon deforestation, shifting monsoon patterns affecting agriculture in the mountain slopes of Peru, floods in Pakistan, water shortages in Middle East, droughts impacting water supplies and wildlife migration in Africa, and sea level rise impacts on low lying coastal communities in Bangladesh. These environmental changes are likely to get exacerbated as the temperatures rise, the weather and climate patterns change, and sea level rise continues. Large populations and billions of dollars of infrastructure could be affected. At Northrop Grumman, we have developed an integrated decision support framework for providing necessary information to stakeholders and planners to adapt to the impacts of climate variability and change at the regional and local levels. This integrated approach takes into account assimilation and exploitation of large and disparate weather and climate data sets, regional downscaling (dynamic and statistical), uncertainty quantification and reduction, and a synthesis of scientific data with demographic and economic data to generate actionable information for the stakeholders and decision makers. Utilizing a flexible service oriented architecture and state-of-the-art visualization techniques, this information can be delivered via tailored GIS portals to meet diverse set of user needs and expectations. This integrated approach can be applied to regional and local risk assessments, predictions and decadal projections, and proactive adaptation planning for vulnerable communities. In this paper we will describe this comprehensive decision support approach with selected applications and case studies to illustrate how this

  7. Integrated assessment of the global warming problem. A decision-analytical approach

    Van Lenthe, J.; Hendrickx, L.; Vlek, C.A.J.

    1995-01-01

    The project on the title subject aims at developing a policy-oriented methodology for the integrated assessment of the global warming problem. Decision analysis in general and influence diagrams in particular appear to constitute an appropriate integrated assessment methodology. The influence-diagram approach is illustrated at a preliminary integrated modeling of the global warming problem. In next stages of the research, attention will be shifted from the methodology of integrated assessment to the contents of integrated models. 4 figs., 5 refs

  8. PWR integral tie plate and locking mechanism

    Flora, B.S.; Osborne, J.L.

    1980-01-01

    A locking mechanism for securing an upper tie plate to the tie rods of a nuclear fuel bundle is described. The mechanism includes an upper tie plate assembly and locking sleeves fixed to the ends of the tie rods. The tie plate is part of the upper tie plate assembly and is secured to the fuel bundle by securing the entire upper tie plate assembly to the locking sleeves fixed to the tie rods. The assembly includes, in addition to the tie plate, locking nuts for engaging the locking sleeves, retaining sleeves to operably connect the locking nuts to the assembly, a spring biased reaction plate to restrain the locking nuts in the locked position and a means to facilitate the removal of the entire assembly as a unit from the fuel bundle

  9. A global first integral for certain dynamical systems and related remarks

    Gonzalez-Gascon, F.

    1977-01-01

    A global first integral for certain dynamical systems and the related remarks are presented. In particular, it is shown that for these dynamical systems by introducing the (intrinsic) definition of the divergence of a vector field defined on an orientable differentiable manifold, the first integral, i.e. the (intrinsic) divergence of a vector field is now, automatically, a global first integral. (author)

  10. Defect vectors and path integrals in fracture mechanics

    Roche, R.L.

    1979-01-01

    Several criteria have been proposed in Elastic Plastic Fracture Mechanics. One of the most interesting ones is the J 1 criterion where J 1 is a path integral surrounding the crack tip. Other path integrals (or surface integrals in 3D problems) can be used. But all these integrals are introduced on an elastic basis, though they are applied in plasticity. This paper shows that it is possible to introduce these integrals without any reference to the elastic behavior of the material. The method is based on the 'defect vector theory' which is an extension of the energy-momentum tensor theory. (orig.)

  11. Thermodynamics and statistical mechanics an integrated approach

    Hardy, Robert J

    2014-01-01

    This textbook brings together the fundamentals of the macroscopic and microscopic aspects of thermal physics by presenting thermodynamics and statistical mechanics as complementary theories based on small numbers of postulates. The book is designed to give the instructor flexibility in structuring courses for advanced undergraduates and/or beginning graduate students and is written on the principle that a good text should also be a good reference. The presentation of thermodynamics follows the logic of Clausius and Kelvin while relating the concepts involved to familiar phenomena and the mod

  12. GLOFRIM v1.0-A globally applicable computational framework for integrated hydrological-hydrodynamic modelling

    Hoch, Jannis M.; Neal, Jeffrey C.; Baart, Fedor; Van Beek, Rens; Winsemius, Hessel C.; Bates, Paul D.; Bierkens, Marc F.P.

    2017-01-01

    We here present GLOFRIM, a globally applicable computational framework for integrated hydrological-hydrodynamic modelling. GLOFRIM facilitates spatially explicit coupling of hydrodynamic and hydrologic models and caters for an ensemble of models to be coupled. It currently encompasses the global

  13. A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant

    Brette, Fabien; Shiels, Holly A.; Galli, Gina L. J.; Cros, Caroline; Incardona, John P.; Scholz, Nathaniel L.; Block, Barbara A.

    2017-01-01

    The Deepwater Horizon disaster drew global attention to the toxicity of crude oil and the potential for adverse health effects amongst marine life and spill responders in the northern Gulf of Mexico. The blowout released complex mixtures of polycyclic aromatic hydrocarbons (PAHs) into critical pelagic spawning habitats for tunas, billfishes, and other ecologically important top predators. Crude oil disrupts cardiac function and has been associated with heart malformations in developing fish. However, the precise identity of cardiotoxic PAHs, and the mechanisms underlying contractile dysfunction are not known. Here we show that phenanthrene, a PAH with a benzene 3-ring structure, is the key moiety disrupting the physiology of heart muscle cells. Phenanthrene is a ubiquitous pollutant in water and air, and the cellular targets for this compound are highly conserved across vertebrates. Our findings therefore suggest that phenanthrene may be a major worldwide cause of vertebrate cardiac dysfunction.

  14. Polymer quantum mechanics some examples using path integrals

    Parra, Lorena; Vergara, J. David

    2014-01-01

    In this work we analyze several physical systems in the context of polymer quantum mechanics using path integrals. First we introduce the group averaging method to quantize constrained systems with path integrals and later we use this procedure to compute the effective actions for the polymer non-relativistic particle and the polymer harmonic oscillator. We analyze the measure of the path integral and we describe the semiclassical dynamics of the systems

  15. In vitro mechanical integrity of hydroxyapatite coated magnesium alloy

    Kannan, M Bobby; Orr, Lynnley

    2011-01-01

    The mechanical integrity of resorbable implants during service, especially in load bearing orthopaedic applications, is critical. The high degradation rate of resorbable magnesium and magnesium-based implants in body fluid may potentially cause premature in-service failure. In this study, a magnesium alloy (AZ91) was potentiostatically coated with hydroxyapatite at different cathodic voltages in an attempt to enhance the mechanical integrity. The mechanical integrity of the uncoated and hydroxyapatite coated alloys was evaluated after in vitro testing of the coated samples in simulated body fluid (SBF). The uncoated alloy showed 40% loss in the mechanical strength after five days exposure to SBF. However, the hydroxyapatite coated alloy exposed to SBF showed 20% improvement in the mechanical strength as compared to that of the uncoated alloy. The alloy coated potentiostatically at -2 V performed better than the -3 V coated alloy. The cross-sectional analysis of the coatings revealed relatively uniform coating thickness for the -2 V coated alloy, whereas the -3 V coated alloy exhibited areas of uneven coating. This can be attributed to the increase in hydrogen evolution on the alloy during -3 V coating as compared to -2 V coating. The scanning electron micrographs of the in vitro tested alloy revealed that hydroxyapatite coating significantly reduced the localized corrosion of the alloy, which is critical for better in-service mechanical integrity. Thus, the study suggests that the in vitro mechanical integrity of resorbable magnesium-based alloy can be improved by potentiostatic hydroxyapatite coating.

  16. In vitro mechanical integrity of hydroxyapatite coated magnesium alloy.

    Kannan, M Bobby; Orr, Lynnley

    2011-08-01

    The mechanical integrity of resorbable implants during service, especially in load bearing orthopaedic applications, is critical. The high degradation rate of resorbable magnesium and magnesium-based implants in body fluid may potentially cause premature in-service failure. In this study, a magnesium alloy (AZ91) was potentiostatically coated with hydroxyapatite at different cathodic voltages in an attempt to enhance the mechanical integrity. The mechanical integrity of the uncoated and hydroxyapatite coated alloys was evaluated after in vitro testing of the coated samples in simulated body fluid (SBF). The uncoated alloy showed 40% loss in the mechanical strength after five days exposure to SBF. However, the hydroxyapatite coated alloy exposed to SBF showed 20% improvement in the mechanical strength as compared to that of the uncoated alloy. The alloy coated potentiostatically at -2 V performed better than the -3 V coated alloy. The cross-sectional analysis of the coatings revealed relatively uniform coating thickness for the -2 V coated alloy, whereas the -3 V coated alloy exhibited areas of uneven coating. This can be attributed to the increase in hydrogen evolution on the alloy during -3 V coating as compared to -2 V coating. The scanning electron micrographs of the in vitro tested alloy revealed that hydroxyapatite coating significantly reduced the localized corrosion of the alloy, which is critical for better in-service mechanical integrity. Thus, the study suggests that the in vitro mechanical integrity of resorbable magnesium-based alloy can be improved by potentiostatic hydroxyapatite coating. © 2011 IOP Publishing Ltd

  17. In vitro mechanical integrity of hydroxyapatite coated magnesium alloy

    Kannan, M Bobby; Orr, Lynnley, E-mail: bobby.mathan@jcu.edu.au [Discipline of Chemical Engineering, School of Engineering and Physical Sciences, James Cook University, Townsville, Queensland 4811 (Australia)

    2011-08-15

    The mechanical integrity of resorbable implants during service, especially in load bearing orthopaedic applications, is critical. The high degradation rate of resorbable magnesium and magnesium-based implants in body fluid may potentially cause premature in-service failure. In this study, a magnesium alloy (AZ91) was potentiostatically coated with hydroxyapatite at different cathodic voltages in an attempt to enhance the mechanical integrity. The mechanical integrity of the uncoated and hydroxyapatite coated alloys was evaluated after in vitro testing of the coated samples in simulated body fluid (SBF). The uncoated alloy showed 40% loss in the mechanical strength after five days exposure to SBF. However, the hydroxyapatite coated alloy exposed to SBF showed 20% improvement in the mechanical strength as compared to that of the uncoated alloy. The alloy coated potentiostatically at -2 V performed better than the -3 V coated alloy. The cross-sectional analysis of the coatings revealed relatively uniform coating thickness for the -2 V coated alloy, whereas the -3 V coated alloy exhibited areas of uneven coating. This can be attributed to the increase in hydrogen evolution on the alloy during -3 V coating as compared to -2 V coating. The scanning electron micrographs of the in vitro tested alloy revealed that hydroxyapatite coating significantly reduced the localized corrosion of the alloy, which is critical for better in-service mechanical integrity. Thus, the study suggests that the in vitro mechanical integrity of resorbable magnesium-based alloy can be improved by potentiostatic hydroxyapatite coating.

  18. Integration of NDE Reliability and Fracture Mechanics

    Becker, F. L.; Doctor, S. R.; Heas!er, P. G.; Morris, C. J.; Pitman, S. G.; Selby, G. P.; Simonen, F. A.

    1981-03-01

    The Pacific Northwest Laboratory is conducting a four-phase program for measuring and evaluating the effectiveness and reliability of in-service inspection (lSI} performed on the primary system piping welds of commercial light water reactors (LWRs). Phase I of the program is complete. A survey was made of the state of practice for ultrasonic rsr of LWR primary system piping welds. Fracture mechanics calculations were made to establish required nondestrutive testing sensitivities. In general, it was found that fatigue flaws less than 25% of wall thickness would not grow to failure within an inspection interval of 10 years. However, in some cases failure could occur considerably faster. Statistical methods for predicting and measuring the effectiveness and reliability of lSI were developed and will be applied in the "Round Robin Inspections" of Phase II. Methods were also developed for the production of flaws typical of those found in service. Samples fabricated by these methods wilI be used in Phase II to test inspection effectiveness and reliability. Measurements were made of the influence of flaw characteristics {i.e., roughness, tightness, and orientation) on inspection reliability. These measurernents, as well as the predictions of a statistical model for inspection reliability, indicate that current reporting and recording sensitivities are inadequate.

  19. GLobal Integrated Design Environment (GLIDE): A Concurrent Engineering Application

    McGuire, Melissa L.; Kunkel, Matthew R.; Smith, David A.

    2010-01-01

    The GLobal Integrated Design Environment (GLIDE) is a client-server software application purpose-built to mitigate issues associated with real time data sharing in concurrent engineering environments and to facilitate discipline-to-discipline interaction between multiple engineers and researchers. GLIDE is implemented in multiple programming languages utilizing standardized web protocols to enable secure parameter data sharing between engineers and researchers across the Internet in closed and/or widely distributed working environments. A well defined, HyperText Transfer Protocol (HTTP) based Application Programming Interface (API) to the GLIDE client/server environment enables users to interact with GLIDE, and each other, within common and familiar tools. One such common tool, Microsoft Excel (Microsoft Corporation), paired with its add-in API for GLIDE, is discussed in this paper. The top-level examples given demonstrate how this interface improves the efficiency of the design process of a concurrent engineering study while reducing potential errors associated with manually sharing information between study participants.

  20. Mechanical shape correlation : a novel integrated digital image correlation approach

    Kleinendorst, S.M.; Hoefnagels, J.P.M.; Geers, M.G.D.; Lamberti, L.; Lin, M.-T.; Furlong, C.; Sciammarella, C.

    2018-01-01

    Mechanical Shape Correlation (MSC) is a novel integrated digital image correlation technique, used to determine the optimal set of constitutive parameters to describe the experimentally observed mechanical behavior of a test specimen, based on digital images taken during the experiment. In contrast

  1. Prediction of thermo-mechanical integrity of wafer backend processes

    Gonda, V.; Toonder, den J.M.J.; Beijer, J.G.J.; Zhang, G.Q.; Hoofman, R.J.O.M.; Ernst, L.J.; Ernst, L.J.

    2003-01-01

    More than 65% of IC failures are related to thermal and mechanical problems. For wafer backend processes, thermo-mechanical failure is one of the major bottlenecks. The ongoing technological trends like miniaturization, introduction of new materials, and function/product integration will increase

  2. Integral transforms of the quantum mechanical path integral: Hit function and path-averaged potential

    Edwards, James P.; Gerber, Urs; Schubert, Christian; Trejo, Maria Anabel; Weber, Axel

    2018-04-01

    We introduce two integral transforms of the quantum mechanical transition kernel that represent physical information about the path integral. These transforms can be interpreted as probability distributions on particle trajectories measuring respectively the relative contribution to the path integral from paths crossing a given spatial point (the hit function) and the likelihood of values of the line integral of the potential along a path in the ensemble (the path-averaged potential).

  3. HBV DNA Integration: Molecular Mechanisms and Clinical Implications

    Tu, Thomas; Budzinska, Magdalena A.; Shackel, Nicholas A.; Urban, Stephan

    2017-01-01

    Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in the host cell genome, despite this form being a replicative dead-end for the virus. The frequent finding of somatic integration of viral DNA suggests an evolutionary benefit for the virus; however, the mechanism of integration, its functions, and the clinical implications remain unknown. Here we review the current body of knowledge of HBV DNA integration, with particular focus on the molecular mechanisms and its clinical implications (including the possible consequences of replication-independent antigen expression and its possible role in hepatocellular carcinoma). HBV DNA integration is likely to influence HBV replication, persistence, and pathogenesis, and so deserves greater attention in future studies. PMID:28394272

  4. Global search tool for the Advanced Photon Source Integrated Relational Model of Installed Systems (IRMIS) database

    Quock, D.E.R.; Cianciarulo, M.B.

    2007-01-01

    The Integrated Relational Model of Installed Systems (IRMIS) is a relational database tool that has been implemented at the Advanced Photon Source to maintain an updated account of approximately 600 control system software applications, 400,000 process variables, and 30,000 control system hardware components. To effectively display this large amount of control system information to operators and engineers, IRMIS was initially built with nine Web-based viewers: Applications Organizing Index, IOC, PLC, Component Type, Installed Components, Network, Controls Spares, Process Variables, and Cables. However, since each viewer is designed to provide details from only one major category of the control system, the necessity for a one-stop global search tool for the entire database became apparent. The user requirements for extremely fast database search time and ease of navigation through search results led to the choice of Asynchronous JavaScript and XML (AJAX) technology in the implementation of the IRMIS global search tool. Unique features of the global search tool include a two-tier level of displayed search results, and a database data integrity validation and reporting mechanism.

  5. High Gain Antenna System Deployment Mechanism Integration, Characterization, and Lessons Learned

    Parong, Fil; Russell, Blair; Garcen, Walter; Rose, Chris; Johnson, Chris; Huber, Craig

    2014-01-01

    The integration and deployment testing of the High Gain Antenna System for the Global Precipitation Measurement mission is summarized. The HGAS deployment mechanism is described. The gravity negation system configuration and its influence on vertical, ground-based, deployment tests are presented with test data and model predictions. A focus is made on the late discovery and resolution of a potentially mission degrading deployment interference condition. The interaction of the flight deployment mechanism, gravity negation mechanism, and use of dynamic modeling is described and lessons learned presented.

  6. Global versus local mechanisms of temperature sensing in ion channels.

    Arrigoni, Cristina; Minor, Daniel L

    2018-05-01

    Ion channels turn diverse types of inputs, ranging from neurotransmitters to physical forces, into electrical signals. Channel responses to ligands generally rely on binding to discrete sensor domains that are coupled to the portion of the channel responsible for ion permeation. By contrast, sensing physical cues such as voltage, pressure, and temperature arises from more varied mechanisms. Voltage is commonly sensed by a local, domain-based strategy, whereas the predominant paradigm for pressure sensing employs a global response in channel structure to membrane tension changes. Temperature sensing has been the most challenging response to understand and whether discrete sensor domains exist for pressure and temperature has been the subject of much investigation and debate. Recent exciting advances have uncovered discrete sensor modules for pressure and temperature in force-sensitive and thermal-sensitive ion channels, respectively. In particular, characterization of bacterial voltage-gated sodium channel (BacNa V ) thermal responses has identified a coiled-coil thermosensor that controls channel function through a temperature-dependent unfolding event. This coiled-coil thermosensor blueprint recurs in other temperature sensitive ion channels and thermosensitive proteins. Together with the identification of ion channel pressure sensing domains, these examples demonstrate that "local" domain-based solutions for sensing force and temperature exist and highlight the diversity of both global and local strategies that channels use to sense physical inputs. The modular nature of these newly discovered physical signal sensors provides opportunities to engineer novel pressure-sensitive and thermosensitive proteins and raises new questions about how such modular sensors may have evolved and empowered ion channel pores with new sensibilities.

  7. Sixth-Grade Students' Progress in Understanding the Mechanisms of Global Climate Change

    Visintainer, Tammie; Linn, Marcia

    2015-01-01

    Developing solutions for complex issues such as global climate change requires an understanding of the mechanisms involved. This study reports on the impact of a technology-enhanced unit designed to improve understanding of global climate change, its mechanisms, and their relationship to everyday energy use. Global Climate Change, implemented in…

  8. Integrating Global Hydrology Into Graduate Engineering Education and Research

    Griffis, V. W.

    2007-12-01

    Worldwide, polluted water affects the health of 1.2 billion people and contributes to the death of 15 million children under five every year. In addition poor environmental quality contributes to 25 per cent of all preventable ill health in the world. To address some of these problems, at the 2002 World Summit on Sustainable Development, the world community set the goal of halving, by the year 2015, the proportion of people without access to safe drinking water and basic sanitation. Solving sanitation and water resource management problems in any part of the world presents an interdisciplinary, complex challenge. However, when we attempt to solve these problems in an international context, our technical approaches must be tempered with cultural sensitivity and extraordinary management strategies. To meet this challenge, Michigan Tech has developed a unique global partnership with the U.S. Peace Corps to address our acknowledgement of the importance of placing engineering solutions in a global context. The program has graduated 30 students. Program enrollment is now over 30 and over 20 countries have hosted our students. The objective of this presentation is to demonstrate how this unique partnership can be integrated with graduate engineering education and research and also show how such a program may attract a more diverse student population into engineering. All graduate students enrolled in our Master's International Program in Civil and Environmental Engineering must complete specific coursework requirements before departing for their international experience. In CE5993 (Field Engineering in the Developing World) students learn to apply concepts of sustainable development and appropriate technology in the developing world. In FW5770 (Rural Community Development Planning and Analysis) students learn how one involves a community in the decision making process. A common theme in both courses is the role of woman in successful development projects. Technical

  9. Managing the tensions in integrating global organisations : The role of performance management systems

    Busco, C.; Giovannoni, E.; Scapens, R.W.

    The paper explores the role of performance management systems (PMSs) in integrating global organisations (GOs). It investigates the ways in which the diverse entities that comprise a GO can be co-ordinated and integrated to achieve a global unity of effort, while leaving space for local adaptation,

  10. The Global Environment Facility (GEF): Right mechanism for improved implementation?

    Andresen, Steinar; Rosendal, Kristin G.

    2012-11-01

    The purpose is to feed into the international discussions of environmental financial mechanisms such as for forestry and mercury by examining the performance of the GEF. We discuss performance against effectiveness and legitimacy and focus on institutional set-up and key actors as explanatory factors. Methodologically, we use document and literature analysis and interviews with key actors in organizations, state representatives and NGOs. The dominant position of the USA and the World Bank has probably contributed to the bias towards a northern environmental agenda and emphasis on effectiveness and climate change projects. The GEF has somewhat predictably diverted the flow of international money from the poorest countries to more rapidly developing countries. Still, despite turf battles between the organizations involved, the broad organisational and thematic composition of the GEF has comparative advantages. This enhances the score on legitimacy especially for biodiversity projects, although they receive less overall funding. The GEF may be seen as an indication of how, regardless of choosing established or new institutions, basic power structures and interests of dominating parties will be largely decisive for what can be achieved in global environmental governance.(auth)

  11. Mechanical Model of Traditional Thai Massage for Integrated Healthcare

    Salinee Rattanaphan

    2015-01-01

    Full Text Available In this study, a mechanical model was developed, aiming to provide standardized and programmable traditional Thai massage (TTM therapy to patients. The TTM was modeled and integrated into a mechanical hand (MH system, and a prototype massage chair was built and tested for user satisfaction. Three fundamental principles of Thai massage were integrated: pull, press, and pin. Based on these principles, the mechanics of Thai massage was studied and a mathematical model was developed to describe the dynamics and conditions for the design and prototyping of an MH. On average, it was found that users were satisfied with the treatment and felt that the treatment was similar to that performed by human hands. According to the interview results, users indicated that they were likely to utilize the MH as an alternative to traditional massage. Therefore, integrated TTM with an MH may help healthcare providers deliver standardized, programmable massage therapy to patients as opposed to variable, inconsistent human massage.

  12. Beyond Scientism and Skepticism: An Integrative Approach to Global Mental Health

    Dan J Stein

    2015-11-01

    Full Text Available The global burden of disorders has shifted from infectious disease to non-communicable diseases, including neuropsychiatric disorders. Whereas infectious disease can sometimes be combated by targeting single causal mechanisms, such as prevention of contact-spread illness by hand-washing, in the case of mental disorders multiple causal mechanisms are relevant. The emergent field of global mental health has emphasized the magnitude of the treatment gap, particularly in the low and middle income world, and has paid particular attention to upstream causal factors, for example, poverty, inequality, and gender discrimination in the pathogenesis of mental disorders. However, this field has also been criticised for relying on erroneous Western paradigms of mental illness, which may not be relevant or appropriate to the low- and middle-income context. Here, it is important to steer a path between scienticism and skepticism. Scientism regards mental disorders as essential categories, and takes a covering law approach to causality; skepticism regards mental disorders as merely social constructions, and emphasizes the role of political power in causal relations. We propose an integrative model that emphasizes the contribution of a broad range of causal mechanisms operating at biological and societal levels to mental disorders, and the consequent importance of broad-spectrum and multi-pronged approaches to intervention.

  13. A Global Integration: Internationalizing a Public Speaking Course

    Lyons, Florence A.

    2017-01-01

    Institutions of higher education around the world have responded to the challenge of globalization by internationalizing their curricula. Incorporating elements of cross-cultural examination to a freshman Fundamentals of Public Speaking class proved to be an important first step toward globalization for this speech professor. In the class,…

  14. General aspects of the mechanical integrity of canisters

    Saario, Timo

    2007-01-01

    This paper attempts to introduce a new point of view to the mechanical integrity of the canisters, 'mechanical integrity evolutionary path'. The mechanical integrity evolutionary path is a description of development of the critical parameters involved in the prevailing degradation modes as a function of time. The degradation mechanisms considered are: mechanical overload; creep; and stress corrosion cracking. For each degradation mechanism one may consider two different states; initial state; critical state. The initial state considered will be different for different degradation mechanisms. For example stress corrosion cracking (SCC), which involves electrochemical steps is not possible without a surface covering aqueous phase. Thus, potentially, the initial state for SCC is that existing after saturation. On the other hand, the initial state for a possible mechanical overload can be different in different periods during the mechanical integrity evolutionary path. During the handling and transport stages the initial state is 'ex works', while during a glaciation the initial state has been altered due to creep, corrosion and possible SCC processes. The canister will go through mechanical overload during saturation and bentonite swelling phases and it will deform to fit the form of the insert. The initial state for this period is 'ex works', with e.g. manufacturing defects. The insert is designed to bear the load after closing the gap. In the 'ex works' state directionality of the mechanical properties has been raised lately as a new issue worth checking. Within the projected evolutionary path two events have been especially considered; seismic events and glaciation. A glacier 2 km thick would increase the hydrostatic pressure with 20 MPa if there were a mechanism transmitting the load into the aqueous phase. Remembering what makes ice skating possible such a mechanism seems plausible. For mechanical overload the critical state is relatively straightforward to

  15. General aspects of the mechanical integrity of canisters

    Saario, Timo [VTT Materials and Building (Finland)

    2007-09-15

    This paper attempts to introduce a new point of view to the mechanical integrity of the canisters, 'mechanical integrity evolutionary path'. The mechanical integrity evolutionary path is a description of development of the critical parameters involved in the prevailing degradation modes as a function of time. The degradation mechanisms considered are: mechanical overload; creep; and stress corrosion cracking. For each degradation mechanism one may consider two different states; initial state; critical state. The initial state considered will be different for different degradation mechanisms. For example stress corrosion cracking (SCC), which involves electrochemical steps is not possible without a surface covering aqueous phase. Thus, potentially, the initial state for SCC is that existing after saturation. On the other hand, the initial state for a possible mechanical overload can be different in different periods during the mechanical integrity evolutionary path. During the handling and transport stages the initial state is 'ex works', while during a glaciation the initial state has been altered due to creep, corrosion and possible SCC processes. The canister will go through mechanical overload during saturation and bentonite swelling phases and it will deform to fit the form of the insert. The initial state for this period is 'ex works', with e.g. manufacturing defects. The insert is designed to bear the load after closing the gap. In the 'ex works' state directionality of the mechanical properties has been raised lately as a new issue worth checking. Within the projected evolutionary path two events have been especially considered; seismic events and glaciation. A glacier 2 km thick would increase the hydrostatic pressure with 20 MPa if there were a mechanism transmitting the load into the aqueous phase. Remembering what makes ice skating possible such a mechanism seems plausible. For mechanical overload the critical

  16. Integrating Thermal Tools Into the Mechanical Design Process

    Tsuyuki, Glenn T.; Siebes, Georg; Novak, Keith S.; Kinsella, Gary M.

    1999-01-01

    The intent of mechanical design is to deliver a hardware product that meets or exceeds customer expectations, while reducing cycle time and cost. To this end, an integrated mechanical design process enables the idea of parallel development (concurrent engineering). This represents a shift from the traditional mechanical design process. With such a concurrent process, there are significant issues that have to be identified and addressed before re-engineering the mechanical design process to facilitate concurrent engineering. These issues also assist in the integration and re-engineering of the thermal design sub-process since it resides within the entire mechanical design process. With these issues in mind, a thermal design sub-process can be re-defined in a manner that has a higher probability of acceptance, thus enabling an integrated mechanical design process. However, the actual implementation is not always problem-free. Experience in applying the thermal design sub-process to actual situations provides the evidence for improvement, but more importantly, for judging the viability and feasibility of the sub-process.

  17. A Physical Mechanism and Global Quantification of Breast Cancer.

    Chong Yu

    Full Text Available Initiation and progression of cancer depend on many factors. Those on the genetic level are often considered crucial. To gain insight into the physical mechanisms of breast cancer, we construct a gene regulatory network (GRN which reflects both genetic and environmental aspects of breast cancer. The construction of the GRN is based on available experimental data. Three basins of attraction, representing the normal, premalignant and cancer states respectively, were found on the phenotypic landscape. The progression of breast cancer can be seen as switching transitions between different state basins. We quantified the stabilities and kinetic paths of the three state basins to uncover the biological process of breast cancer formation. The gene expression levels at each state were obtained, which can be tested directly in experiments. Furthermore, by performing global sensitivity analysis on the landscape topography, six key genes (HER2, MDM2, TP53, BRCA1, ATM, CDK2 and four regulations (HER2⊣TP53, CDK2⊣BRCA1, ATM→MDM2, TP53→ATM were identified as being critical for breast cancer. Interestingly, HER2 and MDM2 are the most popular targets for treating breast cancer. BRCA1 and TP53 are the most important oncogene of breast cancer and tumor suppressor gene, respectively. This further validates the feasibility of our model and the reliability of our prediction results. The regulation ATM→MDM2 has been extensive studied on DNA damage but not on breast cancer. We notice the importance of ATM→MDM2 on breast cancer. Previous studies of breast cancer have often focused on individual genes and the anti-cancer drugs are mainly used to target the individual genes. Our results show that the network-based strategy is more effective on treating breast cancer. The landscape approach serves as a new strategy for analyzing breast cancer on both the genetic and epigenetic levels and can help on designing network based medicine for breast cancer.

  18. Left Atrial Mechanical Function and Global Strain in Hypertrophic Cardiomyopathy.

    Kyung-Jin Kim

    Full Text Available Atrial fibrillation is the most common arrhythmia and is associated with adverse outcomes in hypertrophic cardiomyopathy (HCM. Although left atrial (LA remodeling and dysfunction are known to associate with the development of atrial fibrillation in HCM, the changes of the LA in HCM patients remain unclear. This study aimed to evaluate the changes in LA size and mechanical function in HCM patients compared to control subjects and to determine the characteristics of HCM associated with LA remodeling and dysfunction.Seventy-nine HCM patients (mean age, 54 ± 11 years; 76% were men were compared to 79 age- and sex-matched controls (mean age, 54 ± 11 years; 76% were men and 20 young healthy controls (mean age, 33 ± 5 years; 45% were men. The LA diameter, volume, and mechanical function, including global strain (ε, were evaluated by 2D-speckle tracking echocardiography. The phenotype of HCM, maximal left ventricular (LV wall thickness, LV mass, and presence and extent of late gadolinium enhancement (LGE were evaluated with cardiac magnetic resonance imaging.HCM patients showed increased LA volume index, impaired reservoir function, and decreased LA ε compared to the control subjects. When we divided the HCM group according to a maximal LA volume index (LAVImax of 38.7 ml/m2 or LA ε of 21%, no significant differences in the HCM phenotype and maximal LV wall thickness were observed for patients with LAVImax >38.7 ml/m2 or LA ε ≤21%. Conversely, the LV mass index was significantly higher both in patients with maximal LA volume index >38.7 ml/m2 and with LA ε ≤21% and was independently associated with LAVImax and LA ε. Although the LGE extent was increased in patients with LA ε ≤21%, it was not independently associated with either LAVImax or LA ε.HCM patients showed progressed LA remodeling and dysfunction; the determinant of LA remodeling and dysfunction was LV mass index rather than LV myocardial fibrosis by LGE-magnetic resonance

  19. Mechanical integrity of PFHE in LNG liquefaction process

    Ligterink, N.E.; Hageraats-Ponomareva, S.V.; Velthuis, J.F.M.

    2012-01-01

    The mechanical integrity of heat exchangers is the result of an interplay of many physical phenomena. A full, albeit simple, model, that covers mixture phase thermodynamics, heat transfer, flow dynamics, and the thermal and pressure stresses has been created. Using this simulation model it is now

  20. Burning properties and mechanical integrity of aged gun propellants

    Driel, C.A. van; Klerk, W.P.C. de

    2017-01-01

    Conventional gun propellants exhibit the phenomenon of nitrocellulose (NC) decomposition. Besides an effect on thermal stability of propellants, decomposition of NC has an effect on the mechanical integrity of the propellant grains. Enhanced grain fracture may lead to unacceptable changes of the

  1. The Routh theorem for mechanical systems with unknown first integrals

    Karapetyan Alexander V.

    2017-01-01

    Full Text Available In this paper we discuss problems of stability of stationary motions of conservative and dissipative mechanical systems with first integrals. General results are illustrated by the problem of motion of a rotationally symmetric rigid body on a perfectly rough plane.

  2. Super-Quantum Mechanics in the Integral Form Formalism

    Castellani, L.; Catenacci, R.; Grassi, P. A.

    2018-05-01

    We reformulate Super Quantum Mechanics in the context of integral forms. This framework allows to interpolate between different actions for the same theory, connected by different choices of Picture Changing Operators (PCO). In this way we retrieve component and superspace actions, and prove their equivalence. The PCO are closed integral forms, and can be interpreted as super Poincar\\'e duals of bosonic submanifolds embedded into a supermanifold.. We use them to construct Lagrangians that are top integral forms, and therefore can be integrated on the whole supermanifold. The $D=1, ~N=1$ and the $D=1,~ N=2$ cases are studied, in a flat and in a curved supermanifold. In this formalism we also consider coupling with gauge fields, Hilbert space of quantum states and observables.

  3. Circuit Mechanisms Governing Local vs. Global Motion Processing in Mouse Visual Cortex

    Rune Rasmussen

    2017-12-01

    Full Text Available A withstanding question in neuroscience is how neural circuits encode representations and perceptions of the external world. A particularly well-defined visual computation is the representation of global object motion by pattern direction-selective (PDS cells from convergence of motion of local components represented by component direction-selective (CDS cells. However, how PDS and CDS cells develop their distinct response properties is still unresolved. The visual cortex of the mouse is an attractive model for experimentally solving this issue due to the large molecular and genetic toolbox available. Although mouse visual cortex lacks the highly ordered orientation columns of primates, it is organized in functional sub-networks and contains striate- and extrastriate areas like its primate counterparts. In this Perspective article, we provide an overview of the experimental and theoretical literature on global motion processing based on works in primates and mice. Lastly, we propose what types of experiments could illuminate what circuit mechanisms are governing cortical global visual motion processing. We propose that PDS cells in mouse visual cortex appear as the perfect arena for delineating and solving how individual sensory features extracted by neural circuits in peripheral brain areas are integrated to build our rich cohesive sensory experiences.

  4. Integrating global energy and climate governance: The changing role of the International Energy Agency

    Heubaum, Harald; Biermann, Frank

    2015-01-01

    Despite the long-recognized interlinkages between global energy consumption and climate change, there has historically been only limited policy interaction, let alone integration, between the two fields. This compartmentalization is mirrored in scholarship, where much research has focused on the fragmentation of, respectively, global energy and global climate governance, but only little has been said about how these fields might be integrated. Our analysis of the International Energy Agency’s (IEA) changing activities in recent years shows that governance integration – both within global energy governance and between global energy and climate governance – is now happening. The IEA has broadened its portfolio to embrace the full spectrum of energy issues, including renewable energy and climate change; it has built and is expanding key partnerships with both the UN climate convention and the International Renewable Energy Agency (IRENA); and it has become an authoritative advocate for the inter-related goals of a low-carbon transition and climate change mitigation. We show that these developments are not the result of a top-down plan, but have rather emerged through the Agency’s various efforts to pursue its energy-centric mandate in a fast-changing global policy environment. - Highlights: • Assesses integration between global energy and global climate governance. • Analyzes organizational change in the IEA and its impact on governance integration. • Discusses recent activities and advocacy by the IEA in relation to climate change.

  5. Mechanism of ENSO influence on the South Asian monsoon rainfall in global model simulations

    Joshi, Sneh; Kar, Sarat C.

    2018-02-01

    Coupled ocean atmosphere global climate models are increasingly being used for seasonal scale simulation of the South Asian monsoon. In these models, sea surface temperatures (SSTs) evolve as coupled air-sea interaction process. However, sensitivity experiments with various SST forcing can only be done in an atmosphere-only model. In this study, the Global Forecast System (GFS) model at T126 horizontal resolution has been used to examine the mechanism of El Niño-Southern Oscillation (ENSO) forcing on the monsoon circulation and rainfall. The model has been integrated (ensemble) with observed, climatological and ENSO SST forcing to document the mechanism on how the South Asian monsoon responds to basin-wide SST variations in the Indian and Pacific Oceans. The model simulations indicate that the internal variability gets modulated by the SSTs with warming in the Pacific enhancing the ensemble spread over the monsoon region as compared to cooling conditions. Anomalous easterly wind anomalies cover the Indian region both at 850 and 200 hPa levels during El Niño years. The locations and intensity of Walker and Hadley circulations are altered due to ENSO SST forcing. These lead to reduction of monsoon rainfall over most parts of India during El Niño events compared to La Niña conditions. However, internally generated variability is a major source of uncertainty in the model-simulated climate.

  6. B2B Integration in Global Supply Chains

    Schubert, Petra; Legner, Christine

    2011-01-01

    The competitiveness of businesses is increasingly dependent on their electronic networks with customers, suppliers, and partners. While the strategic and operational impact of external integration and IOS adoption has been extensively studied, much less attention has been paid to the organizational...... and technical design of electronic relationships. The objective of our longitudinal research project is the development of a framework for understanding and explaining B2B integration. Drawing on existing literature and empirical cases we present a reference model (a classification scheme for B2B Integration...

  7. Global Citizenship and the Importance of Education in a Globally Integrated World

    Smith, William C.; Fraser, Pablo; Chykina, Volha; Ikoma, Sakiko; Levitan, Joseph; Liu, Jing; Mahfouz, Julia

    2017-01-01

    As national borders dissipate and technology allows different cultures and nationalities to communicate on a regular basis, more individuals are self-identifying as a global citizen. Using Social Network Analysis and multi-level modelling, this study explores factors associated with global citizen affinity and finds that education plays an…

  8. The mechanism of development of integration processes in the region

    V. M. Bautin

    2017-01-01

    Full Text Available In the context of the weakening economic development of the region, it is necessary to find new ways to increase the efficiency of interaction between the economic structures of the region. One of the areas is the development of integration processes in the field of cooperation between the public and private capital to meet the goals and objectives of the effective functioning of both the participants of integration interaction, as well as the region as a whole. Factors that influence the emergence and development of integration processes, are a scarce resource; motivated by the need to diversify the business; the desire to improve the economic efficiency of business entities. Development grace-integral process is economic interaction managing subjects, followed by combining them to achieve common objectives and obtain the synergistic effect due to a number of resource solutions, organizational and administrative problems. To obtain high economic benefits of integration interaction of the participants, we have proposed a mechanism for the development of integration processes in the region, based on three levels of interaction between regional authorities, educational institutions and private organizations. It allows forming a single chain integration and process management to increase the effectiveness of their implementation in practice, and to avoid the disadvantages associated with the formation of the integrated structures. Integration cooperation of regional authorities with organizations of various spheres of activity of the region and education (research organizations is a key component of the new Russian innovation policy because, if done right, it provides broader benefits from investments in research and development, creating favorable conditions for sustainable innovation development and is a strategic factor in the economic growth of the region.

  9. Global symplectic structure-preserving integrators for spinning compact binaries

    Zhong, Shuang-Ying; Wu, Xin; Liu, San-Qiu; Deng, Xin-Fa

    2010-12-01

    This paper deals mainly with the application of the second-order symplectic implicit midpoint rule and its symmetric compositions to a post-Newtonian Hamiltonian formulation with canonical spin variables in relativistic compact binaries. The midpoint rule, as a basic algorithm, is directly used to integrate the completely canonical Hamiltonian system. On the other hand, there are symmetric composite methods based on a splitting of the Hamiltonian into two parts: the Newtonian part associated with a Kepler motion, and a perturbation part involving the orbital post-Newtonian and spin contributions, where the Kepler flow has an analytic solution and the perturbation can be calculated by the midpoint rule. An example is the second-order mixed leapfrog symplectic integrator with one stage integration of the perturbation flow and two semistage computations of the Kepler flow at every integration step. Also, higher-order composite methods such as the Forest-Ruth fourth-order symplectic integrator and its optimized algorithm are applicable. Various numerical tests including simulations of chaotic orbits show that the mixed leapfrog integrator is always superior to the midpoint rule in energy accuracy, while both of them are almost equivalent in computational efficiency. Particularly, the optimized fourth-order algorithm compared with the mixed leapfrog scheme provides good precision and needs no expensive additional computational time. As a result, it is worth performing a more detailed and careful examination of the dynamical structure of chaos and order in the parameter windows and phase space of the binary system.

  10. Integrating forest products with ecosystem services: a global perspective

    Robert L. Deal; Rachel. White

    2012-01-01

    Around the world forests provide a broad range of vital ecosystem services. Sustainable forest management and forest products play an important role in global carbon management, but one of the major forestry concerns worldwide is reducing the loss of forestland from development. Currently, deforestation accounts for approximately 20% of total greenhouse gas emissions....

  11. Holocaust Education: Global Forces Shaping Curricula Integration and Implementation

    Davis, Bryan L.; Rubinstein-Avila, Eliane

    2013-01-01

    The article provides a critical review of the global scholarship on Holocaust education (HE). Despite the growing body of work on this topic, a search through major academic databases by the authors revealed that no such review of the research literature has been published as of yet. The review focuses on three main themes across the research…

  12. Global pharmaceutical regulation: the challenge of integration for developing states.

    Pezzola, Anthony; Sweet, Cassandra M

    2016-12-20

    This paper has set out to map the state of pharmaceutical regulation in the developing world through the construction of cross-national indices drawing from World Health Organization data. The last two decades have been characterized by deep changes for the pharmaceutical sector, including the complete transformation of intellectual property systems at the behest of the World Trade Organization and the consolidation of global active ingredient suppliers in China and India. Although the rules for ownership of medicine have been set and globally implemented, we know surprisingly little about how the standards for market entrance and regulation of pharmaceutical products have changed at the national level. How standardized are national pharmaceutical market systems? Do we find homogeneity or variation across the developing world? Are their patterns for understanding why some countries have moved closer to one global norm for pharmaceutical regulation and others have developed hybrid models for oversight of this sector? Access to medicine is a core tool in public health. This paper gauges the levels of standards in public and private generics markets for developing countries building on national-level pharmaceutical market surveys for 78 countries to offer three indicators of market oversight: State Regulatory Infrastructure, Monitoring the Private Market and Public Quality Control. Identifying the different variables that affect a state's institutional capacity and current standard level offers new insights to the state of pharmaceuticals in the developing world. It is notable that there are very few (none at the time of this paper) studies that map out the new global terrain for pharmaceutical regulation in the post-TRIPS context. This paper uses item response theory to develop original indicators of pharmaceutical regulation. We find remarkable resistance to the implementation of global pharmaceutical norms for quality standards in developing states and in

  13. Integrating NASA Earth Science Enterprise (ESE) Data Into Global Agricultural Decision Support Systems

    Teng, W.; Kempler, S.; Chiu, L.; Doraiswamy, P.; Liu, Z.; Milich, L.; Tetrault, R.

    2003-12-01

    Monitoring global agricultural crop conditions during the growing season and estimating potential seasonal production are critically important for market development of U.S. agricultural products and for global food security. Two major operational users of satellite remote sensing for global crop monitoring are the USDA Foreign Agricultural Service (FAS) and the U.N. World Food Programme (WFP). The primary goal of FAS is to improve foreign market access for U.S. agricultural products. The WFP uses food to meet emergency needs and to support economic and social development. Both use global agricultural decision support systems that can integrate and synthesize a variety of data sources to provide accurate and timely information on global crop conditions. The Goddard Space Flight Center Earth Sciences Distributed Active Archive Center (GES DAAC) has begun a project to provide operational solutions to FAS and WFP, by fully leveraging results from previous work, as well as from existing capabilities of the users. The GES DAAC has effectively used its recently developed prototype TRMM Online Visualization and Analysis System (TOVAS) to provide ESE data and information to the WFP for its agricultural drought monitoring efforts. This prototype system will be evolved into an Agricultural Information System (AIS), which will operationally provide ESE and other data products (e.g., rainfall, land productivity) and services, to be integrated into and thus enhance the existing GIS-based, decision support systems of FAS and WFP. Agriculture-oriented, ESE data products (e.g., MODIS-based, crop condition assessment product; TRMM derived, drought index product) will be input to a crop growth model in collaboration with the USDA Agricultural Research Service, to generate crop condition and yield prediction maps. The AIS will have the capability for remotely accessing distributed data, by being compliant with community-based interoperability standards, enabling easy access to

  14. Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW) data set measures atmospheric water vapor using ground-based...

  15. INTEGRATION OF TRADE AND DISINTEGRATION OF PRODUCTION IN THE GLOBAL ECONOMY

    Robert Feenstra

    2003-01-01

    The last few decades have seen a spectacular integration of the global economy through trade. The rising integration of world markets has brought with it a disintegration of the production process, however, in which manufacturing or services activities done abroad are combined with those performed at home. The author compares several different measures of foreign outsourcing and argues that they have all increased since the 1970s. He also considers the implications of globalization for employ...

  16. Integrating global socio-economic influences into a regional land use change model for China

    Xu, Xia; Gao, Qiong; Peng, Changhui; Cui, Xuefeng; Liu, Yinghui; Jiang, Li

    2014-03-01

    With rapid economic development and urbanization, land use in China has experienced huge changes in recent years; and this will probably continue in the future. Land use problems in China are urgent and need further study. Rapid land-use change and economic development make China an ideal region for integrated land use change studies, particularly the examination of multiple factors and global-regional interactions in the context of global economic integration. This paper presents an integrated modeling approach to examine the impact of global socio-economic processes on land use changes at a regional scale. We develop an integrated model system by coupling a simple global socio-economic model (GLOBFOOD) and regional spatial allocation model (CLUE). The model system is illustrated with an application to land use in China. For a given climate change, population growth, and various socio-economic situations, a global socio-economic model simulates the impact of global market and economy on land use, and quantifies changes of different land use types. The land use spatial distribution model decides the type of land use most appropriate in each spatial grid by employing a weighted suitability index, derived from expert knowledge about the ecosystem state and site conditions. A series of model simulations will be conducted and analyzed to demonstrate the ability of the integrated model to link global socioeconomic factors with regional land use changes in China. The results allow an exploration of the future dynamics of land use and landscapes in China.

  17. Global Format for Conservative Time Integration in Nonlinear Dynamics

    Krenk, Steen

    2014-01-01

    The widely used classic collocation-based time integration procedures like Newmark, Generalized-alpha etc. generally work well within a framework of linear problems, but typically may encounter problems, when used in connection with essentially nonlinear structures. These problems are overcome....... In the present paper a conservative time integration algorithm is developed in a format using only the internal forces and the associated tangent stiffness at the specific time integration points. Thus, the procedure is computationally very similar to a collocation method, consisting of a series of nonlinear...... equivalent static load steps, easily implemented in existing computer codes. The paper considers two aspects: representation of nonlinear internal forces in a form that implies energy conservation, and the option of an algorithmic damping with the purpose of extracting energy from undesirable high...

  18. Constraint-based query distribution framework for an integrated global schema

    Malik, Ahmad Kamran; Qadir, Muhammad Abdul; Iftikhar, Nadeem

    2009-01-01

    and replicated data sources. The provided system is all XML-based which poses query in XML form, transforms, and integrates local results in an XML document. Contributions include the use of constraints in our existing global schema which help in source selection and query optimization, and a global query...

  19. Global sensitivity analysis of DRAINMOD-FOREST, an integrated forest ecosystem model

    Shiying Tian; Mohamed A. Youssef; Devendra M. Amatya; Eric D. Vance

    2014-01-01

    Global sensitivity analysis is a useful tool to understand process-based ecosystem models by identifying key parameters and processes controlling model predictions. This study reported a comprehensive global sensitivity analysis for DRAINMOD-FOREST, an integrated model for simulating water, carbon (C), and nitrogen (N) cycles and plant growth in lowland forests. The...

  20. Integrating Global Learning into a Psychology Course Using an Online Platform

    Forden, Carie L.; Carrillo, Amy M.

    2014-01-01

    There is a demand for the integration of global learning/diversity across the curriculum. A series of cross-cultural assignments was created to facilitate global learning in two social psychology classes, one in Egypt, and one in the USA. In these assignments, students collected data and applied course concepts to real-life problems, then…

  1. Numerical calculations in elementary quantum mechanics using Feynman path integrals

    Scher, G.; Smith, M.; Baranger, M.

    1980-01-01

    We show that it is possible to do numerical calculations in elementary quantum mechanics using Feynman path integrals. Our method involves discretizing both time and space, and summing paths through matrix multiplication. We give numerical results for various one-dimensional potentials. The calculations of energy levels and wavefunctions take approximately 100 times longer than with standard methods, but there are other problems for which such an approach should be more efficient

  2. INTEGRATION MECHANISMS OF IMPROVEMENT OF HUMAN RESOURCES MANAGEMENT

    Vera A. Akimenko

    2013-01-01

    Full Text Available In the current economic conditions, the efficiency of business processes of an organization is determined by the quality of the staff. Therefore, actual is the creation and application of new approaches to the management of human re-sources. The article presents a comparative analysis of management practices and their impact on the effectiveness of personnel management, the mechanism of their integration to improve the efficiency of the process.

  3. Global Stability in Dynamical Systems with Multiple Feedback Mechanisms

    Andersen, Morten; Vinther, Frank; Ottesen, Johnny T.

    2016-01-01

    A class of n-dimensional ODEs with up to n feedbacks from the n’th variable is analysed. The feedbacks are represented by non-specific, bounded, non-negative C1 functions. The main result is the formulation and proof of an easily applicable criterion for existence of a globally stable fixed point...

  4. Iterative integral parameter identification of a respiratory mechanics model.

    Schranz, Christoph; Docherty, Paul D; Chiew, Yeong Shiong; Möller, Knut; Chase, J Geoffrey

    2012-07-18

    Patient-specific respiratory mechanics models can support the evaluation of optimal lung protective ventilator settings during ventilation therapy. Clinical application requires that the individual's model parameter values must be identified with information available at the bedside. Multiple linear regression or gradient-based parameter identification methods are highly sensitive to noise and initial parameter estimates. Thus, they are difficult to apply at the bedside to support therapeutic decisions. An iterative integral parameter identification method is applied to a second order respiratory mechanics model. The method is compared to the commonly used regression methods and error-mapping approaches using simulated and clinical data. The clinical potential of the method was evaluated on data from 13 Acute Respiratory Distress Syndrome (ARDS) patients. The iterative integral method converged to error minima 350 times faster than the Simplex Search Method using simulation data sets and 50 times faster using clinical data sets. Established regression methods reported erroneous results due to sensitivity to noise. In contrast, the iterative integral method was effective independent of initial parameter estimations, and converged successfully in each case tested. These investigations reveal that the iterative integral method is beneficial with respect to computing time, operator independence and robustness, and thus applicable at the bedside for this clinical application.

  5. Iterative integral parameter identification of a respiratory mechanics model

    Schranz Christoph

    2012-07-01

    Full Text Available Abstract Background Patient-specific respiratory mechanics models can support the evaluation of optimal lung protective ventilator settings during ventilation therapy. Clinical application requires that the individual’s model parameter values must be identified with information available at the bedside. Multiple linear regression or gradient-based parameter identification methods are highly sensitive to noise and initial parameter estimates. Thus, they are difficult to apply at the bedside to support therapeutic decisions. Methods An iterative integral parameter identification method is applied to a second order respiratory mechanics model. The method is compared to the commonly used regression methods and error-mapping approaches using simulated and clinical data. The clinical potential of the method was evaluated on data from 13 Acute Respiratory Distress Syndrome (ARDS patients. Results The iterative integral method converged to error minima 350 times faster than the Simplex Search Method using simulation data sets and 50 times faster using clinical data sets. Established regression methods reported erroneous results due to sensitivity to noise. In contrast, the iterative integral method was effective independent of initial parameter estimations, and converged successfully in each case tested. Conclusion These investigations reveal that the iterative integral method is beneficial with respect to computing time, operator independence and robustness, and thus applicable at the bedside for this clinical application.

  6. Global sourcing - performance and integration : reflections on performance, implications from cross-functional and external integration

    Horn, Philipp

    2013-01-01

    Despite the fact that firms and individuals have been sourcing on a global basis since ancient times, global sourcing as a topic has received considerable attention from managers and scholars in recent years. Global business has been reported to be growing considerably during the last decades and

  7. Development of mechanical design technology for integral reactor

    Park, Keun Bae; Choi, Suhn; Kim, Kang Soo; Kim, Tae Wan; Jeong, Kyeong Hoon; Lee, Gyu Mahn

    1999-03-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose application such as small capacity power generation, co-generation and sea water desalination. With this in mind, an integral reactor SMART is under development. Design concepts, system layout and types of equipment of integral reactor are significantly different from those of loop type reactor. Conceptual design development of mechanical structures of integral reactor SMART is completed through the first stage of the project. Efforts were endeavored for the establishment of design basis and evaluation of applicable codes and standards. Design and functional requirements of major structural components were set up, and three dimensional structural modelling of SMART reactor vessel assembly was prepared. Also, maintenance and repair scheme as well as preliminary fabricability evaluation were carried out. Since small integral reactor technology includes sensitive technologies and know-how's, it is hard to achieve systematic and comprehensive technology transfer from nuclear-advanced countries. Thus, it is necessary to develop the related design technology and to verify the adopted methodologies through test and experiments in order to assure the structural integrity of reactor system. (author)

  8. Development of mechanical design technology for integral reactor

    Park, Keun Bae; Choi, Suhn; Kim, Kang Soo; Kim, Tae Wan; Jeong, Kyeong Hoon; Lee, Gyu Mahn

    1999-03-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose application such as small capacity power generation, co-generation and sea water desalination. With this in mind, an integral reactor SMART is under development. Design concepts, system layout and types of equipment of integral reactor are significantly different from those of loop type reactor. Conceptual design development of mechanical structures of integral reactor SMART is completed through the first stage of the project. Efforts were endeavored for the establishment of design basis and evaluation of applicable codes and standards. Design and functional requirements of major structural components were setup, and three dimensional structural modelling of SMART reactor vessel assembly was prepared. Also, maintenance and repair scheme as well as preliminary fabricability evaluation were carried out. Since small integral reactor technology includes sensitive technologies and know-how's, it is hard to achieve systematic and comprehensive technology transfer from nuclear-advanced countries. Thus, it is necessary to develop the related design technology and to verify the adopted methodologies through test and experiments in order to assure the structural integrity of reactor system. (author)

  9. Leveraging non-binding instruments for global health governance: reflections from the Global AIDS Reporting Mechanism for WHO reform.

    Taylor, A L; Alfven, T; Hougendobler, D; Tanaka, S; Buse, K

    2014-02-01

    As countries contend with an increasingly complex global environment with direct implications for population health, the international community is seeking novel mechanisms to incentivize coordinated national and international action towards shared health goals. Binding legal instruments have garnered increasing attention since the World Health Organization adopted its first convention in 2003. This paper seeks to expand the discourse on future global health lawmaking by exploring the potential value of non-binding instruments in global health governance, drawing on the case of the 2001 United Nations General Assembly Special Session Declaration of Commitment on HIV/AIDS. In other realms of international concern ranging from the environment to human rights to arms control, non-binding instruments are increasingly used as effective instruments of international cooperation. The experience of the Global AIDS Reporting Mechanism, established pursuant to the Declaration, evidences that, at times, non-binding legal instruments can offer benefits over slower, more rigid binding legal approaches to governance. The global AIDS response has demonstrated that the use of a non-binding instrument can be remarkably effective in galvanizing increasingly deep commitments, action, reporting compliance and ultimately accountability for results. Based on this case, the authors argued that non-binding instruments deserve serious consideration by the international community for the future of global health governance, including in the context of WHO reform. Copyright © 2013 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  10. 75 FR 20388 - International Business Machines Corporation, Global Technology Services Business Unit, Integrated...

    2010-04-19

    ... Machines Corporation, Global Technology Services Business Unit, Integrated Technology Services, Cost and... Technology Services Business Unit, Integrated Technology Services, Cost and Expense Team working from various... Technology Services Business Unit. The company reports that workers leased from Datrose, Inc., were employed...

  11. Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.

    Dolinay, Tamas; Himes, Blanca E; Shumyatcher, Maya; Lawrence, Gladys Gray; Margulies, Susan S

    2017-08-01

    Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategies offer only a modest benefit in preventing VILI because they cannot impede alveolar overdistension and concomitant epithelial barrier dysfunction in the inflamed lung regions. There are currently no effective biochemical therapies to mitigate injury to the alveolar epithelium. We hypothesize that alveolar stretch activates the integrated stress response (ISR) pathway and that the chemical inhibition of this pathway mitigates alveolar barrier disruption during stretch and mechanical ventilation. Using our established rat primary type I-like alveolar epithelial cell monolayer stretch model and in vivo rat mechanical ventilation that mimics the alveolar overdistension seen in acute respiratory distress syndrome, we studied epithelial responses to mechanical stress. Our studies revealed that the ISR signaling pathway is a key modulator of epithelial permeability. We show that prolonged epithelial stretch and injurious mechanical ventilation activate the ISR, leading to increased alveolar permeability, cell death, and proinflammatory signaling. Chemical inhibition of protein kinase RNA-like endoplasmic reticulum kinase, an upstream regulator of the pathway, resulted in decreased injury signaling and improved barrier function after prolonged cyclic stretch and injurious mechanical ventilation. Our results provide new evidence that therapeutic targeting of the ISR can mitigate VILI.

  12. Microenvironmental change as a mechanism to study global change.

    Lortie, C. J.

    2016-12-01

    Global change is a set of significant processes that influence all aspects of ecosystem functioning and often-natural services within Santa Barbara County. The sensitivity of coastal and urban systems is certainly very high. However, profound changes are also predicted for arid and semi-arid systems globally, and California is no exception. These dryland systems are less buffered by oceanic processes and typically express high inter-annual variation in precipitation and temperatures in addition to perturbations associated with long-term droughts. However, climate estimates and downscaled values can present challenges in providing evidence at the scale relevant to individual species or individuals, and the importance of biotic interactions must be coupled to these estimates in space and time. Coupled indicators of key micro-environmental measures to both positive and negative interactions between foundation species and other organisms provide a metric of buffering capacity and resilience to global change at fine spatial scales. Consequently, the primary objective of this research project is to provide both the a well-articulated, ecologically relevant micro-environmental big data measure of global change within Santa Barbara County and a coupled estimate of concurrent changes in interactions in key species within the region. Shrubs directly and indirectly buffered local changes in the microenvironment thereby functioning as refuges for other species within arid and semi-arid regions subject to dramatic global change drivers. The following major patterns were identified: (i) shrub micro-environments reduce the level of stress and amplitude of variation associated with temperature and moisture, (ii) many plant and animal species including threatened lizards are relatively more common with shrubs within the region, and (iii) the variation in the interaction patterns between species relates to the extent of amelioration provided by shrub-biodiversity complexes within

  13. Exploring Connections Between Global Integration and Political Mobilization

    Jackie Smith

    2015-08-01

    Full Text Available With the end of the Cold War, military security issues declined on the international agenda as environmental, economic, and social issues rose. As superpower con?ict faded from the international agenda, space was created for new attempts at multilateral problem-solving. How have these changes a?ected the prospects for transnational organizing? Using data from the Yearbook of International Associations this paper explores changes in the size, issue focus, geographic makeup, and organizational structure of the population of transnational social movement organizations (TSMOs in recent decades. While not the only form of transna-tional cooperation, these formal organizations provide important infrastructures for sustained transnational political work. Key ?ndings are that while the transnational social movement sector has continued to grow since the mid-20th century, its rate of growth has slowed in the 1990s. Also, human rights and environment predominate on TSMO issue-agendas, but during the 1990s more groups emphasized economic issues and adopted multi-issue organizing frames over single-issue focuses. Newer groups were more likely to be organized regionally, that is within the global North or South, which may re?ect e?orts to develop structures to better connect local settings with global networks.

  14. Thermal loads and their effect on integrity of mechanical systems and components

    Koenig, G.; Schoeckle, F.

    2010-01-01

    The initial step to establish a required quality status of systems and components is performed during the state of design. Main goal of the design is to consider every possible damage mechanism of the future operation (by specification of loads, medium and environment and the selection of the materials). The knowledge during the state of design determines the reliability of the component. Regarding the thermal loads, especially, only global parameters are specified usually (transients of flow and temperature connected to specified operation). These global transients are analyzed according to the standards. In operation, the safety (integrity) resp. remaining life of a component is determined by the real operation history. As experience showed, failures, defects and not specified (new) loads were discovered during operation, e.g. stratification effects in feedwater pipes and in surge lines or thermal effects in the region of valves due to switching or internal leakage. Standard surveillance in operation is performed using plant transducers that can only monitor global loads. However, problems usually are of local nature. Thermal loads like - turbulent temperatures due to mixing of media with different temperatures - temperature differences across shells or in regions of nozzles/thermal sleeves - temperature differences in piping cross sections (local and global stratification effects) - temperature differences along sections of piping systems have to be monitored by use of local instrumentation. During analysis, both the local loads and construction details have to be considered, in detail, using appropriate calculation / analysis tools. The complexity of the loads requires a comprehensive procedure: - determine the types of loads resulting from measured temperature transients - perform sensitivity studies to identify the load type that results in relevant stresses - evaluate the stresses of the significant loads - assess these stresses according to component

  15. Development of mechanical design technology for integral reactor

    Park, Keun Bae; Choi, Suhn; Kim, Kang Soo; Kim, Tae Wan; Jeong, Kyeong Hoon; Lee, Gyu Mahn; Kim, Jong Wook; Choi, Woo Seok

    2002-03-01

    This report is the final documentation of the 'Development of Mechanical Design Technology for Integral Reactor' which describes the design activities including reactor vessel assembly structural modelling, normal operation and transient analysis, preparation of design specification, major component stress analysis, evaluation of structural integrity, review of fabricability, maintenance and repair scheme, etc. To establish the design requirements and applicable codes and standards, each GDC criterion was reviewed regarding the SMART structural characteristics and design status, and then the applicability and point of issues were evaluated. To accomodate the result of the core optimization program, modification of pressure vessel and reactor internal components were carried out. SG nozzles were rearranged to penetrate the pressure vessel wall instead of the annular cover. Coolant flow path through the MCP impeller was revised and the adjacent structures were modified. Dynamic analysis model was developed reflecting all the structural changes to perform the seismic and BLPB analysis. Fracture mechanics evaluation on the structural integrity of the reactor pressure vessel was also conducted. Besides, equipment maintenance and replacement plan including the refueling scheme was discussed to confirm the embodiment of SMART through construction and operation

  16. A Global MBA for Tomorrow's Global Business Leaders: Integrating Best Practice with Boston's Locational Advantage

    Delaunay, Christian J.; Blodgett, Mark S.

    2005-01-01

    Traditional IB programs have received mixed reviews from the corporate world. With this in mind, the Suffolk GMBA was benchmarked against the leading international business programs. The Suffolk GMBA was designed to be different and to ascertain the global environment in which business operates. A unique feature of the GMBA curriculum detailed in…

  17. Progress toward an Integrated Global Greenhouse Gas Information System (IG3IS)

    DeCola, P.; Butler, J. H.; Stanitski, D.; Tarasova, O. A.; Terblanche, D. E.; Duren, R. M.; Gurney, K. R.; Manning, A.; Reimann, S.; Ciais, P.; Arnold, T.; Burston, J.; Rayner, P. J.; Wofsy, S. C.; Hamburg, S.; Zavala-Araiza, D.; Miller, J. B.; Gerbig, C.; Vogel, F. R.; Canadell, J.

    2016-12-01

    Accurate and precise atmospheric long-term measurements of greenhouse gas (GHG) concentrations have revealed the rapid and unceasing rise of global GHG concentrations due to human socioeconomic activity. Long-term observations also show a resulting rise in global temperatures and evidence of negative impacts on society. In response to this mounting evidence, nations, sub-national governments, private enterprises and individuals are establishing and accelerating efforts to reduce GHG emissions while meeting the needs for global development and increasing energy access. With this motivation, WMO and its partners have called for an Integrated Global Greenhouse Information System (IG3IS). The IG3IS will serve as an international coordinating mechanism to establish and propagate consistent methods and standards to help assess emission-reduction actions. For the IG3IS initiative to succeed the end users must understand, trust, and recognize the value of the information they receive, and act more effectively in response. Over time, the IG3IS framework will be capable of promoting and accepting advancing technical capabilities (e.g., new satellite observations), continually improving the quality of and confidence in such information. By combining accurate atmospheric measurements with enhanced socioeconomic activity data and model analyses we can meet the overarching goals of IG3IS to: Reduce uncertainty of emission inventory reporting, Locate, quantify and prioritize previously unknown emission reduction opportunities, and Provide national and sub-national governments with timely and quantified information to support their assessment of progress towards their mitigation goals. An effective IG3IS will provide on-going, observation-based information on the relative success of GHG management efforts on policy-relevant scales and the response of the global carbon cycle to a warming world. The presentation will cover the principles and objectives of IG3IS, as well as progress

  18. Defect forces, defect couples and path integrals in fracture mechanics

    Roche, R.L.

    1979-07-01

    In this work, it is shown that the path integrals can be introduced without any reference to the material behavior. The method is based on the definition in a continuous medium of a set of vectors and couples having the dimension of a force or a moment. More precisely, definitions are given of volume defect forces, surface defect forces, volume defect couples, and surface defect couples. This is done with the help of the stress working variation of a particule moving through the solid. The most important result is: the resultant of all the defect forces included in a volume V is the J integral on the surface surrounding V and the moment resultant is the L integral. So these integrals are defined without any assumption on the material constitutive equation. Another result is the material form of the virtual work principle - defect forces are acting like conventional forces in the conventional principles of virtual work. This lead to the introduction of the energy momentum tensor and of the associated couple stress. Application of this method is made to fracture mechanics in studying the defect forces distribution around a crack [fr

  19. Is the corporate loan market globally integrated? a pricing puzzle

    Mark S. Carey; Gregory P. Nini

    2004-01-01

    We offer evidence that interest rate spreads on syndicated loans to corporate borrowers are economically significantly smaller in Europe than in the U.S., other things equal. Differences in borrower, loan and lender characteristics associated with equilibrium mechanisms suggested in the literature do not appear to explain the phenomenon. Borrowers overwhelmingly issue in their natural home market and bank portfolios display significant home "bias." This may explain why pricing discrepancies a...

  20. Integrated assessment of the global warming problem: A decision-analytical approach

    Van Lenthe, J.; Hendrickx, L.; Vlek, C.A.J.

    1994-12-01

    The multi-disciplinary character of the global warming problem asks for an integrated assessment approach for ordering and combining the various physical, ecological, economical, and sociological results. The Netherlands initiated their own National Research Program (NRP) on Global Air Pollution and Climate Change (NRP). The first phase (NRP-1) identified the integration theme as one of five central research themes. The second phase (NRP-2) shows a growing concern for integrated assessment issues. The current two-year research project 'Characterizing the risks: a comparative analysis of the risks of global warming and of relevant policy options, which started in September 1993, comes under the integrated assessment part of the Dutch NRP. The first part of the interim report describes the search for an integrated assessment methodology. It starts with emphasizing the need for integrated assessment at a relatively high level of aggregation and from a policy point of view. The conclusion will be that a decision-analytical approach might fit the purpose of a policy-oriented integrated modeling of the global warming problem. The discussion proceeds with an account on decision analysis and its explicit incorporation and analysis of uncertainty. Then influence diagrams, a relatively recent development in decision analysis, are introduced as a useful decision-analytical approach for integrated assessment. Finally, a software environment for creating and analyzing complex influence diagram models is discussed. The second part of the interim report provides a first, provisional integrated modeling of the global warming problem, emphasizing on the illustration of the decision-analytical approach. Major problem elements are identified and an initial problem structure is developed. The problem structure is described in terms of hierarchical influence diagrams. At some places the qualitative structure is filled with quantitative data

  1. Noether symmetries and integrability in time-dependent Hamiltonian mechanics

    Jovanović Božidar

    2016-01-01

    Full Text Available We consider Noether symmetries within Hamiltonian setting as transformations that preserve Poincaré-Cartan form, i.e., as symmetries of characteristic line bundles of nondegenerate 1-forms. In the case when the Poincaré-Cartan form is contact, the explicit expression for the symmetries in the inverse Noether theorem is given. As examples, we consider natural mechanical systems, in particular the Kepler problem. Finally, we prove a variant of the theorem on complete (non-commutative integrability in terms of Noether symmetries of time-dependent Hamiltonian systems.

  2. Mechanisms for integration of information models across related domains

    Atkinson, Rob

    2010-05-01

    It is well recognised that there are opportunities and challenges in cross-disciplinary data integration. A significant barrier, however, is creating a conceptual model of the combined domains and the area of integration. For example, a groundwater domain application may require information from several related domains: geology, hydrology, water policy, etc. Each domain may have its own data holdings and conceptual models, but these will share various common concepts (eg. The concept of an aquifer). These areas of semantic overlap present significant challenges, firstly to choose a single representation (model) of a concept that appears in multiple disparate models,, then to harmonise these other models with the single representation. In addition, models may exist at different levels of abstraction depending on how closely aligned they are with a particular implementation. This makes it hard for modellers in one domain to introduce elements from another domain without either introducing a specific style of implementation, or conversely dealing with a set of abstract patterns that are hard to integrate with existing implementations. Models are easier to integrate if they are broken down into small units, with common concepts implemented using common models from well-known, and predictably managed shared libraries. This vision however requires development of a set of mechanisms (tools and procedures) for implementing and exploiting libraries of model components. These mechanisms need to handle publication, discovery, subscription, versioning and implementation of models in different forms. In this presentation a coherent suite of such mechanisms is proposed, using a scenario based on re-use of geosciences models. This approach forms the basis of a comprehensive strategy to empower domain modellers to create more interoperable systems. The strategy address a range of concerns and practice, and includes methodologies, an accessible toolkit, improvements to available

  3. A Global Rapid Integrated Monitoring System for Water Cycle and Water Resource Assessment (Global-RIMS)

    Roads, John; Voeroesmarty, Charles

    2005-01-01

    The main focus of our work was to solidify underlying data sets, the data processing tools and the modeling environment needed to perform a series of long-term global and regional hydrological simulations leading eventually to routine hydrometeorological predictions. A water and energy budget synthesis was developed for the Mississippi River Basin (Roads et al. 2003), in order to understand better what kinds of errors exist in current hydrometeorological data sets. This study is now being extended globally with a larger number of observations and model based data sets under the new NASA NEWS program. A global comparison of a number of precipitation data sets was subsequently carried out (Fekete et al. 2004) in which it was further shown that reanalysis precipitation has substantial problems, which subsequently led us to the development of a precipitation assimilation effort (Nunes and Roads 2005). We believe that with current levels of model skill in predicting precipitation that precipitation assimilation is necessary to get the appropriate land surface forcing.

  4. Global Navigation Satellite Systems (GNSS: The Utmost Interdisciplinary Integrator

    Bernd Eissfeller

    2015-08-01

    Full Text Available Currently four global satellite navigation systems are under modernization and development: The US American GPS III, the Russian GLONASS, the European Galileo and Chinese BeiDou systems. In the paper the interdisciplinary contributions of different scientific areas to GNSS are assessed. It is outlined that GNSS is not only a technical system but also a basic element of mobile computing high-tech market. At the same time a GNSS has the role of a force enabler in security related applications. Technology, market and security policies are interdependent and are sometimes in a relationship of tension. The goal of the paper is to describe the overall systemics of GNSS from a holistic point of view. The paper also addresses the human factor side of GNSS. The requirements on human resources in GNSS are at least two-fold: On the one hand very specialized engineers are needed; on the other hand the generalists are necessary who are able to understand the system aspects. Decision makers in institutions and industry need special knowledge in technologies, economics and political strategies. Is the current university system able to educate and prepare such generalists? Are specialized master courses for GNSS needed? Are external training courses necessary?

  5. Global chaos synchronization of electro-mechanical gyrostat systems via variable substitution control

    Chen Yun; Wu Xiaofeng; Liu Zhong

    2009-01-01

    This paper studies global synchronization of non-autonomous chaotic electro-mechanical gyrostat systems via variable substitution control. A master-slave non-autonomous synchronization scheme with variable substitution control is mathematically presented. Based on the scheme, some sufficient algebraic criteria for global chaos synchronization of master and slave electro-mechanical gyrostat systems via various single-variable coupling are derived. The effectiveness of the obtained criteria is numerically illustrated by the examples.

  6. Integrated design of castings: effect of porosity on mechanical performance

    Hardin, R A; Beckermann, C

    2012-01-01

    Porosity can significantly reduce the strength and durability of castings in service. An integrated design approach has been developed where casting simulation is combined with mechanical performance simulations. Predictions of the porosity distribution from the casting process simulation are transferred to and used in stress and fatigue life simulations. Thus, the effect of casting quality on service performance can be evaluated. Results of a study are presented where the measured porosity distribution in cast steel specimens is transferred to an elasto-plastic finite-element stress analysis model. Methods are developed to locally reduce the mechanical properties according to the porosity present, without having to resolve individual pores. Plastic deformation is modeled using porous metal plasticity theory. The predictions are compared to tensile measurements performed on the specimens. The complex deformations and the reductions in the ductility of the specimens due to porosity are predicted well. The predicted stresses are transferred to a fatigue analysis code that takes the porosity distribution into account as well. The measured and predicted fatigue lives are also in good agreement. Finally, the results of a case study are presented that illustrate the utility of the present integrated approach in optimizing the design of a steel casting.

  7. Integrable systems and lie symmetries in classical mechanics

    Sen, T.

    1986-01-01

    The interrelationship between integrability and symmetries in classical mechanics is studied. Two-dimensional time- and velocity-independent potentials form the domain of the study. It is shown that, contrary to folklore, existence of a single finite symmetry does not ensure integrability. A method due to Darboux is used to construct potentials that admit a time-independent invariant. All potentials admitting invariants linear or quadratic in the momentum coordinates are constructed. These are the only integrable potentials which can be expressed as arbitrary functions of certain arguments. A complete construction of potentials admitting higher-order invariants does not seem possible. However, the necessary general forms for potentials that admit a particular invariant of arbitrary order are found. These invariants must be spherically symmetric in the leading terms. Two kinds of symmetries are studied: point Lie symmetries of the Newtonian equations of motion for conservative potentials, and point Noether symmetries of the action functionals obtained from the standard Lagrangians associated with these potentials. All conservative potentials which admit these symmetries are constructed. The class of potentials admitting Noether symmetries is shown to be a subclass of those admitting Lie symmetries

  8. Earth science information: Planning for the integration and use of global change information

    Lousma, Jack R.

    1992-01-01

    Activities and accomplishments of the first six months of the Consortium for International Earth Science Information Network (CIESIN's) 1992 technical program have focused on four main missions: (1) the development and implementation of plans for initiation of the Socioeconomic Data and Applications Center (SEDAC) as part of the EOSDIS Program; (2) the pursuit and development of a broad-based global change information cooperative by providing systems analysis and integration between natural science and social science data bases held by numerous federal agencies and other sources; (3) the fostering of scientific research into the human dimensions of global change and providing integration between natural science and social science data and information; and (4) the serving of CIESIN as a gateway for global change data and information distribution through development of the Global Change Research Information Office and other comprehensive knowledge sharing systems.

  9. Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions.

    Brautigam, Chad A; Zhao, Huaying; Vargas, Carolyn; Keller, Sandro; Schuck, Peter

    2016-05-01

    Isothermal titration calorimetry (ITC) is a powerful and widely used method to measure the energetics of macromolecular interactions by recording a thermogram of differential heating power during a titration. However, traditional ITC analysis is limited by stochastic thermogram noise and by the limited information content of a single titration experiment. Here we present a protocol for bias-free thermogram integration based on automated shape analysis of the injection peaks, followed by combination of isotherms from different calorimetric titration experiments into a global analysis, statistical analysis of binding parameters and graphical presentation of the results. This is performed using the integrated public-domain software packages NITPIC, SEDPHAT and GUSSI. The recently developed low-noise thermogram integration approach and global analysis allow for more precise parameter estimates and more reliable quantification of multisite and multicomponent cooperative and competitive interactions. Titration experiments typically take 1-2.5 h each, and global analysis usually takes 10-20 min.

  10. Asymmetric cell division requires specific mechanisms for adjusting global transcription.

    Mena, Adriana; Medina, Daniel A; García-Martínez, José; Begley, Victoria; Singh, Abhyudai; Chávez, Sebastián; Muñoz-Centeno, Mari C; Pérez-Ortín, José E

    2017-12-01

    Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division mechanisms and cell fate consequences have been investigated, the specific problem caused by asymmetric division at the transcription level has not yet been addressed. In symmetrically dividing cells the nascent transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA synthesis rate constant. This cannot apply to the yeast Saccharomyces cerevisiae, where this mechanism would provoke a never-ending increasing mRNA synthesis rate in smaller daughter cells. We show here that, contrarily to other eukaryotes with symmetric division, budding yeast keeps the nascent transcription rates of its RNA polymerases constant and increases mRNA stability. This control on RNA pol II-dependent transcription rate is obtained by controlling the cellular concentration of this enzyme. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  11. Progress toward an Integrated Global GHG Information System (IG3IS)

    DeCola, Philip

    2016-04-01

    Accurate and precise atmospheric measurements of greenhouse gas (GHG) concentrations have shown the inexorable rise of global GHG concentrations due to human socioeconomic activity. Scientific observations also show a resulting rise in global temperatures and evidence of negative impacts on society. In response to this amassing evidence, nations, states, cities and private enterprises are accelerating efforts to reduce emissions of GHGs, and the UNFCCC process recently forged the Paris Agreement. Emission reduction strategies will vary by nation, region, and economic sector (e.g., INDCs), but regardless of the strategies and mechanisms applied, the ability to implement policies and manage them effectively over time will require consistent, reliable and timely information. A number of studies [e.g., Verifying Greenhouse Gas Emissions: Methods to Support International Climate Agreements (2010); GEO Carbon Strategy (2010); IPCC Task Force on National GHG Inventories: Expert Meeting Report on Uncertainty and Validation of Emission Inventories (2010)] have reported on the state of carbon cycle research, observations and models and the ability of these atmospheric observations and models to independently validate and improve the accuracy of self-reported emission inventories based on fossil fuel usage and land use activities. These studies concluded that by enhancing our in situ and remote-sensing observations and atmospheric data assimilation modeling capabilities, a GHG information system could be achieved in the coming decade to serve the needs of policies and actions to reduce GHG emissions. Atmospheric measurements and models are already being used to provide emissions information on a global and continental scale through existing networks, but these efforts currently provide insufficient information at the human-dimensions where nations, states, cities, and private enterprises can take valuable, and additional action that can reduce emissions for a specific GHG

  12. Integrating Natural Gas Hydrates in the Global Carbon Cycle

    David Archer; Bruce Buffett

    2011-12-31

    We produced a two-dimensional geological time- and basin-scale model of the sedimentary margin in passive and active settings, for the simulation of the deep sedimentary methane cycle including hydrate formation. Simulation of geochemical data required development of parameterizations for bubble transport in the sediment column, and for the impact of the heterogeneity in the sediment pore fluid flow field, which represent new directions in modeling methane hydrates. The model is somewhat less sensitive to changes in ocean temperature than our previous 1-D model, due to the different methane transport mechanisms in the two codes (pore fluid flow vs. bubble migration). The model is very sensitive to reasonable changes in organic carbon deposition through geologic time, and to details of how the bubbles migrate, in particular how efficiently they are trapped as they rise through undersaturated or oxidizing chemical conditions and the hydrate stability zone. The active margin configuration reproduces the elevated hydrate saturations observed in accretionary wedges such as the Cascadia Margin, but predicts a decrease in the methane inventory per meter of coastline relative to a comparable passive margin case, and a decrease in the hydrate inventory with an increase in the plate subduction rate.

  13. Limits of policy intervention in a world of neoliberal mechanism designs: Paradoxes of the global crisis

    Dymski Gary A.

    2011-01-01

    Full Text Available The current global context poses several paradoxes: the recovery from the 2009 recession was not a recovery; investment, normally driven by profit rates, is lagging and not leading economic activity; the crisis is global but debate involves sub-global levels; and public safety-nets, which have helped to stabilize national income, are being cut. These paradoxes can be traced, in part, to the impact of the “truce” that followed the Keynesian-Monetarist controversy on economists’ ideas about policy activism. This implicit “truce” has removed activist macro policy from discussion, and shifted attention toward institutions as mechanisms for solving game-theoretic coordination problems. Policy activism then centers on how the “agents” (nations can achieve optimal use of their available resources (or optimal access to resources at the global level; and this involves creating and fine-tuning compacts - neoliberal mechanism designs - that can capture rents and attract globally mobile capital. This approach leads economists to see the key problem in the current global crisis as fixing broken neoliberal mechanisms. However, a global economy dominated by mechanisms that feed on aggregate demand without generating it faces the prospect of stagnation or collapse.

  14. Data integration reveals key homeostatic mechanisms following low dose radiation exposure

    Tilton, Susan C.; Matzke, Melissa M. [Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA 99338 (United States); Sowa, Marianne B.; Stenoien, David L.; Weber, Thomas J. [Health Impacts and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99338 (United States); Morgan, William F. [Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99338 (United States); Waters, Katrina M., E-mail: katrina.waters@pnnl.gov [Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99338 (United States)

    2015-05-15

    The goal of this study was to define pathways regulated by low dose radiation to understand how biological systems respond to subtle perturbations in their environment and prioritize pathways for human health assessment. Using an in vitro 3-D human full thickness skin model, we have examined the temporal response of dermal and epidermal layers to 10 cGy X-ray using transcriptomic, proteomic, phosphoproteomic and metabolomic platforms. Bioinformatics analysis of each dataset independently revealed potential signaling mechanisms affected by low dose radiation, and integrating data shed additional insight into the mechanisms regulating low dose responses in human tissue. We examined direct interactions among datasets (top down approach) and defined several hubs as significant regulators, including transcription factors (YY1, MYC and CREB1), kinases (CDK2, PLK1) and a protease (MMP2). These data indicate a shift in response across time — with an increase in DNA repair, tissue remodeling and repression of cell proliferation acutely (24–72 h). Pathway-based integration (bottom up approach) identified common molecular and pathway responses to low dose radiation, including oxidative stress, nitric oxide signaling and transcriptional regulation through the SP1 factor that would not have been identified by the individual data sets. Significant regulation of key downstream metabolites of nitrative stress was measured within these pathways. Among the features identified in our study, the regulation of MMP2 and SP1 was experimentally validated. Our results demonstrate the advantage of data integration to broadly define the pathways and networks that represent the mechanisms by which complex biological systems respond to perturbation. - Highlights: • Low dose ionizing radiation altered homeostasis in 3D skin tissue model. • Global gene/protein/metabolite data integrated using complementary statistical approaches • Time and location-specific change in matrix regulation

  15. GLOFRIM v1.0 – A globally applicable computational framework for integrated hydrological–hydrodynamic modelling

    Hoch, J.M.; Neal, Jeffrey; Baart, Fedor; van Beek, L.P.H.; Winsemius, Hessel; Bates, Paul; Bierkens, M.F.P.

    2017-01-01

    We here present GLOFRIM, a globally applicable computational framework for integrated hydrological–hydrodynamic modelling. GLOFRIM facilitates spatially explicit coupling of hydrodynamic and hydrologic models and caters for an ensemble of models to be coupled. It currently encompasses the global

  16. Path integral for spinning particle in the plane wave field: Global and local projections

    Boudiaf, N.; Boudjedaa, T.; Chetouani, L.

    2001-01-01

    The Green function related to the problem of a Dirac particle interacting with a plane wave is calculated via the path integral formalism proposed recently by Alexandrou et al. according to the two so-called global and local projections. With the help of the incorporation of two simple identities, it is shown that the contribution to the calculation of the integrals comes essentially from classical solutions projected along the direction of wave propagation. (orig.)

  17. Semantic Data Integration and Ontology Use within the Global Earth Observation System of Systems (GEOSS) Global Water Cycle Data Integration System

    Pozzi, W.; Fekete, B.; Piasecki, M.; McGuinness, D.; Fox, P.; Lawford, R.; Vorosmarty, C.; Houser, P.; Imam, B.

    2008-12-01

    The inadequacies of water cycle observations for monitoring long-term changes in the global water system, as well as their feedback into the climate system, poses a major constraint on sustainable development of water resources and improvement of water management practices. Hence, The Group on Earth Observations (GEO) has established Task WA-08-01, "Integration of in situ and satellite data for water cycle monitoring," an integrative initiative combining different types of satellite and in situ observations related to key variables of the water cycle with model outputs for improved accuracy and global coverage. This presentation proposes development of the Rapid, Integrated Monitoring System for the Water Cycle (Global-RIMS)--already employed by the GEO Global Terrestrial Network for Hydrology (GTN-H)--as either one of the main components or linked with the Asian system to constitute the modeling system of GEOSS for water cycle monitoring. We further propose expanded, augmented capability to run multiple grids to embrace some of the heterogeneous methods and formats of the Earth Science, Hydrology, and Hydraulic Engineering communities. Different methodologies are employed by the Earth Science (land surface modeling), the Hydrological (GIS), and the Hydraulic Engineering Communities; with each community employing models that require different input data. Data will be routed as input variables to the models through web services, allowing satellite and in situ data to be integrated together within the modeling framework. Semantic data integration will provide the automation to enable this system to operate in near-real-time. Multiple data collections for ground water, precipitation, soil moisture satellite data, such as SMAP, and lake data will require multiple low level ontologies, and an upper level ontology will permit user-friendly water management knowledge to be synthesized. These ontologies will have to have overlapping terms mapped and linked together. so

  18. Paved with good intentions: global financial integration and the eurozone’s response

    Underhill, G.R.D.

    2011-01-01

    Regional governance systems may resolve the dilemmas of global financial integration, and the Eurozone is the most advanced attempt to do so. The Euroland sovereign debt crisis is a test of this proposition but the outcome finds the EU wanting. The first section places EMU in the broader context of

  19. How integration of global omics-data could help preparing for pandemics - a scent of influenza

    Bos, Lieuwe D. J.; de Jong, Menno D.; Sterk, Peter J.; Schultz, Marcus J.

    2014-01-01

    Pandemics caused by novel emerging or re-emerging infectious diseases could lead to high mortality and morbidity world-wide when left uncontrolled. In this perspective, we evaluate the possibility of integration of global omics-data in order to timely prepare for pandemics. Such an approach requires

  20. The Influence of Globalization, Integration and Regionalization Processes on the European States and Regions

    T V Bazarenko

    2013-12-01

    Full Text Available The article deals with the impact of globalization, regionalization and integration in European countries and regions. It discusses the distinctive features and factors of influence of each of these processes on the European countries and sub national entities.

  1. Flexible mechanisms in the corporate greenhouse: implementation of the Kyoto Protocol and the globalization of the electric power industry

    Schreuder, Y.; Sherry, C. [University of Delaware, Newark, DE (United States). Center for Energy and Environmental Policy

    2001-07-01

    The contradictions and unresolved tensions between economic globalization and climate change negotiations have added urgency to the climate change debate. The paper argues that the declining role of the nation state in the global economy and the increasing reach of transnational corporations throughout the world present a serious challenge to the environmental integrity and success of international environmental treaties such as the Kyoto Protocol. In particular efficacy and equity of the flexible mechanism under the Kyoto Protocol are questioned as illustrated by the patterns of Foreign Direct Investment (FDI) of the US electric power industry in the developing world. US FDI in the electric power sectors of developing countries supports continued carbon-intensive development patterns which will make the long-term goals of the Kyoto Protocol more difficult to achieve. Consequently, FDI raises questions about justifiability of giving credit to Annex I countries through CDM projects undertaken by transnational electric power corporations. 13 refs.

  2. Integrated regional changes in arctic climate feedbacks: Implications for the global climate system

    McGuire, A.D.; Chapin, F. S.; Walsh, J.E.; Wirth, C.; ,

    2006-01-01

    The Arctic is a key part of the global climate system because the net positive energy input to the tropics must ultimately be resolved through substantial energy losses in high-latitude regions. The Arctic influences the global climate system through both positive and negative feedbacks that involve physical, ecological, and human systems of the Arctic. The balance of evidence suggests that positive feedbacks to global warming will likely dominate in the Arctic during the next 50 to 100 years. However, the negative feedbacks associated with changing the freshwater balance of the Arctic Ocean might abruptly launch the planet into another glacial period on longer timescales. In light of uncertainties and the vulnerabilities of the climate system to responses in the Arctic, it is important that we improve our understanding of how integrated regional changes in the Arctic will likely influence the evolution of the global climate system. Copyright ?? 2006 by Annual Reviews. All rights reserved.

  3. Integration and disintegration processes of ethnic communities in a globalized world: challenges and trends

    A. A. Paronikian

    2016-06-01

    Full Text Available The article examines the challenges and trends in integration and disintegration processes of ethnic communities in the world of globalization. Established that ethnic disintegration is inevitable consequence of ethnic integration, and its intensity depends on what method is carried Integration: voluntary or forced. What is important is the fact that in the era of globalization integration and disintegration processes of ethnic communities that are inherent in the very essence of ethnicity, greatly amplified. It was found that entering to the cultural field of ethnic communities of other ethnic entities, penalized sustainable ethnic balance, contributes to the phenomenon of «rejection of other» causes of ethnic conflict and the consequent threat of disintegration of ethnic communities. Disintegration often leads to weakening of the linkages and interactions between components of the integrated system in a multi-ethnic society. However, the author concludes that the process of disintegration cannot be regarded as unambiguously negative because, on the one hand, it contributes to the weakening and decline; and sometimes division of multi-ethnic countries, but on the other hand - it contributes to the birth of the new and revival of the old nation-states, which is particularly important in conditions of transformation of the global community towards the post-industrial and information epoch in the future. In general, the integration and disintegration change each other depending on global processes and their transformations. Therefore, in the era of globalization’s challenges it is important is the effective management of these processes to prevent adverse effects.

  4. Sixth-Grade Students' Progress in Understanding the Mechanisms of Global Climate Change

    Visintainer, Tammie; Linn, Marcia

    2015-04-01

    Developing solutions for complex issues such as global climate change requires an understanding of the mechanisms involved. This study reports on the impact of a technology-enhanced unit designed to improve understanding of global climate change, its mechanisms, and their relationship to everyday energy use. Global Climate Change, implemented in the Web-based Inquiry Science Environment (WISE), engages sixth-grade students in conducting virtual investigations using NetLogo models to foster an understanding of core mechanisms including the greenhouse effect. Students then test how the greenhouse effect is enhanced by everyday energy use. This study draws on three data sources: (1) pre- and post-unit interviews, (2) analysis of embedded assessments following virtual investigations, and (3) contrasting cases of two students (normative vs. non-normative understanding of the greenhouse effect). Results show the value of using virtual investigations for teaching the mechanisms associated with global climate change. Interviews document that students hold a wide range of ideas about the mechanisms driving global climate change. Investigations with models help students use evidence-based reasoning to distinguish their ideas. Results show that understanding the greenhouse effect offers a foundation for building connections between everyday energy use and increases in global temperature. An impediment to establishing coherent understanding was the persistence of an alternative conception about ozone as an explanation for climate change. These findings illustrate the need for regular revision of curriculum based on classroom trials. We discuss key design features of models and instructional revisions that can transform the teaching and learning of global climate change.

  5. The recent activities of nuclear power globalization. Our provision against global warming by global deployment of our own technologies as integrated nuclear power plant supply company'

    Yamauchi, Kiyoshi; Suzuki, Shigemitsu

    2008-01-01

    Mitsubishi Heavy Industries, Ltd. (MHI) is striving to expand and spread nuclear power plants as an 'Integrated Nuclear Power Plant Supply Company' based on its engineering, manufacturing, and technological support capabilities. The company also has ample experience in the export of major components. MHI is accelerating its global deployment through the market introduction of large-sized strategic reactor US-APWR, the joint development of a mid-sized strategic reactor ATMEA1 with AREVA, and a small strategic reactor PBMR. The company also plans to internationally deploy technologies for the nuclear fuel cycle. We present here the leading-edge trends in the global deployment of these nuclear businesses, all of which help to solve the energy and environmental issues in the world. (author)

  6. Direct experimental visualization of the global Hamiltonian progression of two-dimensional Lagrangian flow topologies from integrable to chaotic state

    Baskan, O.; Clercx, H. J. H [Fluid Dynamics Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (Netherlands); Speetjens, M. F. M. [Energy Technology Laboratory, Department of Mechanical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (Netherlands); Metcalfe, G. [Commonwealth Scientific and Industrial Research Organisation, Melbourne, Victoria 3190 (Australia); Swinburne University of Technology, Department of Mechanical Engineering, Hawthorn VIC 3122 (Australia)

    2015-10-15

    Countless theoretical/numerical studies on transport and mixing in two-dimensional (2D) unsteady flows lean on the assumption that Hamiltonian mechanisms govern the Lagrangian dynamics of passive tracers. However, experimental studies specifically investigating said mechanisms are rare. Moreover, they typically concern local behavior in specific states (usually far away from the integrable state) and generally expose this indirectly by dye visualization. Laboratory experiments explicitly addressing the global Hamiltonian progression of the Lagrangian flow topology entirely from integrable to chaotic state, i.e., the fundamental route to efficient transport by chaotic advection, appear non-existent. This motivates our study on experimental visualization of this progression by direct measurement of Poincaré sections of passive tracer particles in a representative 2D time-periodic flow. This admits (i) accurate replication of the experimental initial conditions, facilitating true one-to-one comparison of simulated and measured behavior, and (ii) direct experimental investigation of the ensuing Lagrangian dynamics. The analysis reveals a close agreement between computations and observations and thus experimentally validates the full global Hamiltonian progression at a great level of detail.

  7. Direct experimental visualization of the global Hamiltonian progression of two-dimensional Lagrangian flow topologies from integrable to chaotic state.

    Baskan, O; Speetjens, M F M; Metcalfe, G; Clercx, H J H

    2015-10-01

    Countless theoretical/numerical studies on transport and mixing in two-dimensional (2D) unsteady flows lean on the assumption that Hamiltonian mechanisms govern the Lagrangian dynamics of passive tracers. However, experimental studies specifically investigating said mechanisms are rare. Moreover, they typically concern local behavior in specific states (usually far away from the integrable state) and generally expose this indirectly by dye visualization. Laboratory experiments explicitly addressing the global Hamiltonian progression of the Lagrangian flow topology entirely from integrable to chaotic state, i.e., the fundamental route to efficient transport by chaotic advection, appear non-existent. This motivates our study on experimental visualization of this progression by direct measurement of Poincaré sections of passive tracer particles in a representative 2D time-periodic flow. This admits (i) accurate replication of the experimental initial conditions, facilitating true one-to-one comparison of simulated and measured behavior, and (ii) direct experimental investigation of the ensuing Lagrangian dynamics. The analysis reveals a close agreement between computations and observations and thus experimentally validates the full global Hamiltonian progression at a great level of detail.

  8. Abnormal global processing along the dorsal visual pathway in autism: a possible mechanism for weak visuospatial coherence?

    Pellicano, Elizabeth; Gibson, Lisa; Maybery, Murray; Durkin, Kevin; Badcock, David R

    2005-01-01

    Frith and Happe (Frith, U., & Happe, F. (1994). Autism: Beyond theory of mind. Cognition, 50, 115-132) argue that individuals with autism exhibit 'weak central coherence': an inability to integrate elements of information into coherent wholes. Some authors have speculated that a high-level impairment might be present in the dorsal visual pathway in autism, and furthermore, that this might account for weak central coherence, at least at the visuospatial level. We assessed the integrity of the dorsal visual pathway in children diagnosed with an autism spectrum disorder (ASD), and in typically developing children, using two visual tasks, one examining functioning at higher levels of the dorsal cortical stream (Global Dot Motion (GDM)), and the other assessing lower-level dorsal stream functioning (Flicker Contrast Sensitivity (FCS)). Central coherence was tested using the Children's Embedded Figures Test (CEFT). Relative to the typically developing children, the children with ASD had shorter CEFT latencies and higher GDM thresholds but equivalent FCS thresholds. Additionally, CEFT latencies were inversely related to GDM thresholds in the ASD group. These outcomes indicate that the elevated global motion thresholds in autism are the result of high-level impairments in dorsal cortical regions. Weak visuospatial coherence in autism may be in the form of abnormal cooperative mechanisms in extra-striate cortical areas, which might contribute to differential performance when processing stimuli as Gestalts, including both dynamic (i.e., global motion perception) and static (i.e., disembedding performance) stimuli.

  9. The role of size constancy for the integration of local elements into a global shape

    Johannes eRennig

    2013-07-01

    Full Text Available Visual perception depends on the visual context and is likely to be influenced by size constancy, which predicts a size and distance invariant perception of objects. However, size constancy can also result in optical illusions that allow the manipulation of the perceived size. We thus asked whether the integration of local elements into a global object can be influenced by manipulations of the visual context and size constancy? A set of stimuli was applied in healthy individuals that took advantage of the ‘Kanizsa’ illusion, in which three circles with open wedges oriented towards a center point are placed to form an illusionary perception of a triangle. In addition, a 3D-perspective view was implemented in which the global target (‘Kanizsa’ triangle was placed in combination with several distractor circles either in a close or a distant position. Subjects were engaged in a global recognition task on the location of the ‘Kanizsa’ triangle. Global recognition of ‘Kanizsa’ triangles improved with a decreasing length of the illusory contour. Interestingly, recognition of ‘Kanizsa’ triangles decreased when they were perceived as if they were located further away. We conclude that the integration of local elements into a global object is dependent on the visual context and dominated by size constancy.

  10. Infrared and visible images registration with adaptable local-global feature integration for rail inspection

    Tang, Chaoqing; Tian, Gui Yun; Chen, Xiaotian; Wu, Jianbo; Li, Kongjing; Meng, Hongying

    2017-12-01

    Active thermography provides infrared images that contain sub-surface defect information, while visible images only reveal surface information. Mapping infrared information to visible images offers more comprehensive visualization for decision-making in rail inspection. However, the common information for registration is limited due to different modalities in both local and global level. For example, rail track which has low temperature contrast reveals rich details in visible images, but turns blurry in the infrared counterparts. This paper proposes a registration algorithm called Edge-Guided Speeded-Up-Robust-Features (EG-SURF) to address this issue. Rather than sequentially integrating local and global information in matching stage which suffered from buckets effect, this algorithm adaptively integrates local and global information into a descriptor to gather more common information before matching. This adaptability consists of two facets, an adaptable weighting factor between local and global information, and an adaptable main direction accuracy. The local information is extracted using SURF while the global information is represented by shape context from edges. Meanwhile, in shape context generation process, edges are weighted according to local scale and decomposed into bins using a vector decomposition manner to provide more accurate descriptor. The proposed algorithm is qualitatively and quantitatively validated using eddy current pulsed thermography scene in the experiments. In comparison with other algorithms, better performance has been achieved.

  11. 78 FR 10181 - Global Quality Systems-An Integrated Approach To Improving Medical Product Safety; Public Workshop

    2013-02-13

    ...] Global Quality Systems--An Integrated Approach To Improving Medical Product Safety; Public Workshop... (AFDO), is announcing a public workshop entitled ``Global Quality Systems--An Integrated Approach to... topics concerning FDA requirements related to the production and marketing of drugs and/or devices...

  12. European integration dimension of Republic of Moldova as development path in a globalization setting

    Natalia ANTOCI

    2015-12-01

    Full Text Available In a global market economy, the opening towards outward, standard harmonization and convergence of national economies can create the necessary synergy in order to address the challenges of globalization. Republic of Moldova needs to develop partnership relations with European Union (EU countries, which have experience in relation to commodity markets, and without which it is difficult to modernize the economy and diversify its export. Moldova's integration into the European Union allows increasing dynamism and sustainability of the economic system of our country and allows implementing a new model of economic growth according to EU Member States' experience.

  13. Integrating mechanisms of visual guidance in naturalistic language production.

    Coco, Moreno I; Keller, Frank

    2015-05-01

    Situated language production requires the integration of visual attention and linguistic processing. Previous work has not conclusively disentangled the role of perceptual scene information and structural sentence information in guiding visual attention. In this paper, we present an eye-tracking study that demonstrates that three types of guidance, perceptual, conceptual, and structural, interact to control visual attention. In a cued language production experiment, we manipulate perceptual (scene clutter) and conceptual guidance (cue animacy) and measure structural guidance (syntactic complexity of the utterance). Analysis of the time course of language production, before and during speech, reveals that all three forms of guidance affect the complexity of visual responses, quantified in terms of the entropy of attentional landscapes and the turbulence of scan patterns, especially during speech. We find that perceptual and conceptual guidance mediate the distribution of attention in the scene, whereas structural guidance closely relates to scan pattern complexity. Furthermore, the eye-voice span of the cued object and its perceptual competitor are similar; its latency mediated by both perceptual and structural guidance. These results rule out a strict interpretation of structural guidance as the single dominant form of visual guidance in situated language production. Rather, the phase of the task and the associated demands of cross-modal cognitive processing determine the mechanisms that guide attention.

  14. Integration of nondestructive examination reliability and fracture mechanics

    Doctor, S.R.; Bates, D.J.; Charlot, L.A.

    1985-01-01

    The primary pressure boundaries (pressure vessels and piping) of nuclear power plants are in-service inspected (ISI) according to the rules of ASME Boiler and Pressure Vessel Code, Section XI. Ultrasonic techniques are normally used for these inspections, which are periodically performed on a sampling of welds. The Integration of Nondestructive Examination (NDE) Reliability and Fracture Mechanics (FM) Program at Pacific Northwest Laboratory was established to determine the reliability of current ISI techniques and to develop recommendations that will ensure a suitably high inspection reliability. The objectives of this NRC program are to: 1) determine the reliability of ultrasonic ISI performed on commercial light-water reactor primary systems; 2) using probabilistic FM analysis, determine the impact of NDE unreliability on system safety and determine the level of inspection reliability required to ensure a suitably low failure probability; 3) evaluate the degree of reliability improvement that could be achieved using improved and advanced NDE techniques; and 4) based on material properties, service conditions, and NDE uncertainties, formulate recommended revisions to ASME Code, Section XI, and Regulatory Requirements needed to ensure suitably low failure probabilities

  15. New application of functional integrals to classical mechanics

    Zherebtsov, Anton; Ilinski, Kirill

    2005-01-01

    In this Letter a new functional integral representation for classical dynamics is introduced. It is achieved by rewriting the Liouville picture in terms of bosonic creation-annihilation operators and utilizing the standard derivation of functional integrals for dynamical quantities in the coherent states representation. This results in a new class of functional integrals which are exactly solvable and can be found explicitly when the underlying classical systems are integrable

  16. Defect-vectors and path integrals in fracture mechanics

    Roche, R.L.

    1979-01-01

    It seems necessary to introduce the J integral without hypothesis on material behavior. The aim of this paper is this introduction and its consequences. Successively are presented: introduction to defect-vectors and defect-momentum, definition of J(K) and J(L) integrals, equilibrium and energy momentum tensor, energetic signification of the path J and L integrals, and local aspects of the criteria based on path integrals [fr

  17. Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity

    Qiu-Yan Zhang

    2017-01-01

    Full Text Available Stroke is a leading cause of morbidity and mortality globally. Leonurine (also named SCM-198, a compound extracted from Herba leonuri, was effective on the prevention of various cardiovascular and brain diseases. The purpose of this study was to explore the possible therapeutic potential of SCM-198 against ischemia reperfusion injury and underlying mechanisms. In the in vivo transient middle cerebral artery occlusion (tMCAO rat model, we found that treatment with SCM-198 could decrease infarct volume and improve neurological deficit by protecting against blood-brain barrier (BBB breakdown. In the in vitro model of cell oxygen-glucose deprivation and reoxygenation (OGD/R, consistent results were obtained with decreased reactive oxygen species (ROS production and maintained the BBB integrity. Further study demonstrated that SCM-198 increased the expression of histone deacetylase- (HDAC- 4 which could inhibit NADPH oxidase- (NOX- 4 and matrix metalloproteinase- (MMP- 9 expression, resulting in the elevation of tight junction proteins, including claudin-5, occludin, and zonula occluden- (ZO- 1. These results indicated SCM-198 protected BBB integrity by regulating the HDAC4/NOX4/MMP-9 tight junction pathway. Our findings provided novel insights into the protective effects and mechanisms of SCM-198 on ischemic stroke, indicating SCM-198 as a new class of potential drug against acute onset of ischemic stroke.

  18. Integration of large chemical kinetic mechanisms via exponential methods with Krylov approximations to Jacobian matrix functions

    Bisetti, Fabrizio

    2012-06-01

    Recent trends in hydrocarbon fuel research indicate that the number of species and reactions in chemical kinetic mechanisms is rapidly increasing in an effort to provide predictive capabilities for fuels of practical interest. In order to cope with the computational cost associated with the time integration of stiff, large chemical systems, a novel approach is proposed. The approach combines an exponential integrator and Krylov subspace approximations to the exponential function of the Jacobian matrix. The components of the approach are described in detail and applied to the ignition of stoichiometric methane-air and iso-octane-air mixtures, here described by two widely adopted chemical kinetic mechanisms. The approach is found to be robust even at relatively large time steps and the global error displays a nominal third-order convergence. The performance of the approach is improved by utilising an adaptive algorithm for the selection of the Krylov subspace size, which guarantees an approximation to the matrix exponential within user-defined error tolerance. The Krylov projection of the Jacobian matrix onto a low-dimensional space is interpreted as a local model reduction with a well-defined error control strategy. Finally, the performance of the approach is discussed with regard to the optimal selection of the parameters governing the accuracy of its individual components. © 2012 Copyright Taylor and Francis Group, LLC.

  19. Integrated rice-duck farming mitigates the global warming potential in rice season.

    Xu, Guochun; Liu, Xin; Wang, Qiangsheng; Yu, Xichen; Hang, Yuhao

    2017-01-01

    Integrated rice-duck farming (IRDF), as a mode of ecological agriculture, is an important way to realize sustainable development of agriculture. A 2-year split-plot field experiment was performed to evaluate the effects of IRDF on methane (CH 4 ) and nitrous oxide (N 2 O) emissions and its ecological mechanism in rice season. This experiment was conducted with two rice farming systems (FS) of IRDF and conventional farming (CF) under four paddy-upland rotation systems (PUR): rice-fallow (RF), annual straw incorporating in rice-wheat rotation system (RWS), annual straw-based biogas residues incorporating in rice-wheat rotation system (RWB), and rice-green manure (RGM). During the rice growing seasons, IRDF decreased the CH 4 emission by 8.80-16.68%, while increased the N 2 O emission by 4.23-15.20%, when compared to CF. Given that CH 4 emission contributed to 85.83-96.22% of global warming potential (GWP), the strong reduction in CH 4 emission led to a significantly lower GWP of IRDF as compared to CF. The reason for this trend was because IRDF has significant effect on dissolved oxygen (DO) and soil redox potential (Eh), which were two pivotal factors for CH 4 and N 2 O emissions in this study. The IRDF not only mitigates the GWP, but also increases the rice yield by 0.76-2.43% compared to CF. Moreover, compared to RWS system, RF, RWB and RGM systems significantly reduced CH 4 emission by 50.17%, 44.89% and 39.51%, respectively, while increased N 2 O emission by 10.58%, 14.60% and 23.90%, respectively. And RWS system had the highest GWP. These findings suggest that mitigating GWP and improving rice yield could be simultaneously achieved by the IRDF, and employing suitable PUR would benefit for relieving greenhouse effect. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Global format for energy-momentum based time integration in nonlinear dynamics

    Krenk, Steen

    2014-01-01

    A global format is developed for momentum and energy consistent time integration of second‐order dynamic systems with general nonlinear stiffness. The algorithm is formulated by integrating the state‐space equations of motion over the time increment. The internal force is first represented...... of mean value products at the element level or explicit use of a geometric stiffness matrix. An optional monotonic algorithmic damping, increasing with response frequency, is developed in terms of a single damping parameter. In the solution procedure, the velocity is eliminated and the nonlinear...

  1. The EU as a global ecological power: The logics of market integration

    Laurent, Eloi; Le Cacheux, Jacques

    2010-05-01

    In this paper, we try to show how the EU became a global ecological power, i.e. a power that influences environmental policies throughout the world. While the existing literature stresses the significance of normative power, regulatory politics and multi-level governance in this process, we highlight the importance of what we call the logics of market integration. By that we mean the decisive role of Single market integration in fostering convergence of environmental policies at the European level as well as in extending European influence at the global level. We illustrate our approach with the case of climate policy, detailing the EU's influence on economic instruments developed worldwide to mitigate climate change. (authors)

  2. An Image Matching Algorithm Integrating Global SRTM and Image Segmentation for Multi-Source Satellite Imagery

    Xiao Ling

    2016-08-01

    Full Text Available This paper presents a novel image matching method for multi-source satellite images, which integrates global Shuttle Radar Topography Mission (SRTM data and image segmentation to achieve robust and numerous correspondences. This method first generates the epipolar lines as a geometric constraint assisted by global SRTM data, after which the seed points are selected and matched. To produce more reliable matching results, a region segmentation-based matching propagation is proposed in this paper, whereby the region segmentations are extracted by image segmentation and are considered to be a spatial constraint. Moreover, a similarity measure integrating Distance, Angle and Normalized Cross-Correlation (DANCC, which considers geometric similarity and radiometric similarity, is introduced to find the optimal correspondences. Experiments using typical satellite images acquired from Resources Satellite-3 (ZY-3, Mapping Satellite-1, SPOT-5 and Google Earth demonstrated that the proposed method is able to produce reliable and accurate matching results.

  3. Analysis of two way fluid structure interaction and local material properties of brazed joints for estimation of mechanical integrity

    Kang, Seok Hoon; Park, Sang Hu; Son, Chang Min; Ha, Man Young; Min, June Kee; Jeong, Ho Sung [Pusan Nat' l Univ., Busan (Korea, Republic of); Cho, Jongrae [Korea Maritime Univ., Busan (Korea, Republic of); Kim, Hyun Jun [Donghwa Entec Co., Ltd., Busan (Korea, Republic of)

    2013-01-15

    Recent years have witnessed a strong need for eco friendly and energy efficient systems owing to global environmental problems. A heat exchanger is a well known mechanical rig that has long been used in many energy systems. The use of a heat exchanger in an airplane engine has been attempted. In this case, the heat exchanger should be redesigned to be compact, lightweight, and highly reliable, and the issue of mechanical integrity gains importance. Therefore, in this study, we proposed a method for evaluating the mechanical integrity of a tube type heat exchanger. A U shaped single tube was used as an example, and its behavior and stress distribution were studied using fluid structure interaction (FSI) analysis.

  4. Optimization of the pumping ring in a mechanical seal with an integrated cooler for feed-water pumps

    Buchdahl, D.; Martin, R.; Gueret, G.; Blanc, M.

    1994-07-01

    To simplify maintenance, E.D.F. along with its collaborators undertook the study of mechanical seal with integrated cooler used in feed-water pumps in the nuclear power plants. The cooler, integrated to the pump acts as a thermal barrier as well as a cooler of the mechanical seal. The water circulation in the cooler is assumed by an integrated pumping ring in the rotary part of the mechanical seal, with a matching screw thread in the pumping case. This assembly of mechanical seal/integrated cooler is tested in a test loop at the EDF/DER Laboratory. All working conditions are similar to that at site. Tests with different configurations of the rotor/stator profiles are performed, i.e.; different lengths and types of threading. Hydraulic performances and the global thermal balance of this assembly are studied. Our basic aim during these tests is to optimize the hydraulic performance of the pumping ring so as to best cool the mechanical seal faces. The different results obtained and the conclusions drawn during these tests are presented. (authors). 7 figs., 3 refs

  5. Integrating place-specific livelihood and equity outcomes into global assessments of bioenergy deployment

    Creutzig, Felix; Corbera, Esteve; Bolwig, Simon

    2013-01-01

    -study research focused on first-generation biofuel crops to demonstrate that food, income, land and other assets such as health are key livelihood dimensions that can be impacted by such crops and we highlight how place-specific and global dynamics influence both aggregate and distributional outcomes across......Integrated assessment models suggest that the large-scale deployment of bioenergy could contribute to ambitious climate change mitigation efforts. However, such a shift would intensify the global competition for land, with possible consequences for 1.5 billion smallholder livelihoods...... these livelihood dimensions. We argue that place-specific production models and land tenure regimes mediate livelihood outcomes, which are also in turn affected by global and regional markets and their resulting equilibrium dynamics. The place-specific perspective suggests that distributional consequences...

  6. Toward a global norm against manipulating the integrity of financial data

    Maurer, Tim; Levite, Ariel; Perkovich, George

    2017-01-01

    The financial crisis that erupted in 2007 highlighted how important trust is for the global system and how fragile it can be. The 2016 Bangladesh central bank cyber incident exposed a new threat to financial stability and the unprecedented scale of the risk that malicious cyber actors pose to financial institutions. Beyond theft, using cyber operations to manipulate the integrity of data, in particular, poses a distinct and greater set of systemic risks than other forms of financial coercion....

  7. Financial Integration of European Money Market: from EMU to the Global Crisis and Beyond

    Avadanei Andreea; Avadanei Anamaria; Ghiba Nicolae

    2010-01-01

    The scope of this article is to illustrate the general issues relevant for understanding the implications of the global crisis on European money market integration. We structured our paper on chapters that present the evolution of the considered market from the launch of euro until the financial turmoil, its main features in the actual context, and the central banks response to the rising tensions on the money market. Given its function of channeling funds to enable banks to cover their most ...

  8. Mechanical Integrity of Copper Canister Lid and Cylinder. Sensitivity study

    Karlsson, Marianne

    2002-08-01

    This report is part of a study of the mechanical integrity of canisters used for disposal of nuclear fuel waste. The overall objective is to determine and ensure the static and long-term strength of the copper canister lid and cylinder casing. The canisters used for disposal nuclear fuel waste of type BWR consists of an inner part (insert) of ductile cast iron and an outer part of copper. The copper canister is to provide a sealed barrier between the contents of the canister and the surroundings. The study in this report complements the finite element analyses performed in an earlier study. The analyses aim to evaluate the sensitivity of the canister to tolerances regarding the gap between the copper cylinder and the cast iron insert. Since great uncertainties regarding the material's long term creep properties prevail, analyses are also performed to evaluate the effect of different creep data on the resulting strain and stress state. The report analyses the mechanical response of the lid and flange of the copper canister when subjected to loads caused by pressure from swelling bentonite and from groundwater at a depth of 500 meter. The loads acting on the canister are somewhat uncertain and the cases investigated in this report are possible cases. Load cases analysed are: Pressure 15 MPa uniformly distributed on lid and 5 MPa uniformly distributed on cylinder; Pressure 5 MPa uniformly distributed on lid and 15 MPa uniformly distributed on cylinder; Pressure 20 MPa uniformly distributed on lid and cylinder; and Side pressures 10 MPa and 20 MPa uniformly distributed on part of the cylinder. Creep analyses are performed for two of the load cases. For all considered designs high principal stresses appear on the outside of the copper cylinder in the region from the weld down to the level of the lid lower edge. Altering the gap between lid and cylinder and/or between cylinder and insert only marginally affects the resulting stress state. Fitting the lid in the cylinder

  9. Global Combustion Mechanisms for Use in CFD Modeling under Oxy-Fuel Conditions

    Andersen, Jimmy; Rasmussen, Christian Lund; Giselsson, Trine

    2009-01-01

    Two global multistep schemes, the two-step mechanism of Westbrook and Dryer (WD) and the four-step mechanism of Jones and Lindstedt (JL), have been refined for oxy-fuel conditions. Reference calculations were conducted with a detailed chemical kinetic mechanism, validated for oxy-fuel combustion...... conditions. In the modification approach, the initiating reactions involving hydrocarbon and oxygen were retained, while modifying the H-2-CO-CO2 reactions in order to improve prediction of major species concentrations. The main attention has been to capture the trend and level of CO predicted...... by the detailed mechanism as well as the correct equilibrium concentration. A CFD analysis of a propane oxy-fuel flame has been performed using both the original and modified mechanisms. Compared to the original schemes, the modified WD mechanism improved the prediction of the temperature field and of CO...

  10. The mechanical and microbiological integrity of surgical gloves.

    Jamal, Ala; Wilkinson, Stephen

    2003-03-01

    Several manufacturers supply surgical gloves that have been individually tested (IT) for leaks. Other manufacturers supply gloves in which sample gloves from each batch are tested for leaks (batch tested: BT). The latter brands may be rejected by surgeons because of presumed increased risk of wound infection and staff exposure to patient pathogens. The influence of differences between glove brands on performance in surgery has not been extensively studied. The aims of the present study were to test the mechanical and microbiological integrity of IT compared to BT gloves. A total of 110 unused gloves from each of an IT and a BT brand were tested for leaks, first, by observation of water-jets from water-filled gloves and second, by measuring electrical resistance between inside and outside the glove surfaces, to give a baseline measure. A total of 304 IT and 280 BT gloves were then similarly leak-tested after 98 clean surgical procedures. The hands and gloves of scrub team members were cultured postsurgery. A total of 1/110 BT and 0/110 IT unused gloves contained leaks (NS, Fisher's exact test). Operative perforation rates were lower for BT compared with IT (8/280 cf. 22/304; P leak rates for unused gloves. Paradoxically, although IT gloves were more likely to show macro-perforations after surgery, the incidence of contamination on the surface of BT gloves was greater, possibly reflecting a qualitative difference in glove material. This study suggests that both types of gloves develop microporosity during use, which may allow transfer of bacteria from the surgeon's skin to the surface of the glove.

  11. Plant communities as drivers of soil respiration: pathways, mechanisms, and significance for global change

    Metcalfe, D. B.; Fisher, R. A.; Wardle, D. A.

    2011-08-01

    Understanding the impacts of plant community characteristics on soil carbon dioxide efflux (R) is a key prerequisite for accurate prediction of the future carbon (C) balance of terrestrial ecosystems under climate change. However, developing a mechanistic understanding of the determinants of R is complicated by the presence of multiple different sources of respiratory C within soil - such as soil microbes, plant roots and their mycorrhizal symbionts - each with their distinct dynamics and drivers. In this review, we synthesize relevant information from a wide spectrum of sources to evaluate the current state of knowledge about plant community effects on R, examine how this information is incorporated into global climate models, and highlight priorities for future research. Despite often large variation amongst studies and methods, several general trends emerge. Mechanisms whereby plants affect R may be grouped into effects on belowground C allocation, aboveground litter properties and microclimate. Within vegetation types, the amount of C diverted belowground, and hence R, may be controlled mainly by the rate of photosynthetic C uptake, while amongst vegetation types this should be more dependent upon the specific C allocation strategies of the plant life form. We make the case that plant community composition, rather than diversity, is usually the dominant control on R in natural systems. Individual species impacts on R may be largest where the species accounts for most of the biomass in the ecosystem, has very distinct traits to the rest of the community and/or modulates the occurrence of major natural disturbances. We show that climate vegetation models incorporate a number of pathways whereby plants can affect R, but that simplifications regarding allocation schemes and drivers of litter decomposition may limit model accuracy. We also suggest that under a warmer future climate, many plant communities may shift towards dominance by fast growing plants which

  12. Integrated regional assessment of global climatic change. Lessons from the Mackenzie Basin Impact Study (MBIS)

    Cohen, Stewart J.

    1996-01-01

    This paper outlines the potential role integrated regional assessments of global climatic change scenarios could play in building better links between science and related policy concerns. The concept is illustrated through description of an ongoing case study from Canada-the Mackenzie Basin Impact Study (MBIS). As part of the Government of Canada's Green Plan, the Global Warming Science Program includes a study of regional impacts of global warming scenarios in the Mackenzie Basin, located in northwestern Canada. The MBIS is a six-year program focussing on potential climate-induced changes in the land and water resource base, and the implications of four scenarios of global climatic change on land use and economic policies in this region. These policy issues include interjurisdictional water management, sustainability of native lifestyles, economic development opportunities (agriculture, forestry, tourism, etc.), sustainability of ecosystems and infrastructure maintenance. MBIS is due to be completed in 1997. MBIS represents an attempt to address regional impacts by incorporating a 'family of integrators' into the study framework, and by directly involving stakeholders in planning and research activities. The experience in organizing and carrying out this project may provide some lessons for others interested in organizing regional or country studies

  13. Integrating Into the Global Economy Through Services. The Case of Romania

    Agnes Ghibuțiu

    2014-04-01

    Full Text Available Services represent a most important and dynamic frontier of international trade and investment. The steady expansion of trade in services and its relative resilience in the recent crisis, coupled with its key role in global production networks and its increasing potential in attracting investment provides new opportunities for countries to grow their economies and integrate into the global economy. Drawing on insights from current literature and relying on balance of payments and trade in value-added statistics, this paper examines the main developments shaping Romania’s services trade over the post-crisis years. Its aim is to assess whether the country is grabbing the new opportunities arising from services globalization. It finds that following the dramatic crisis-induced decline in the value and performance of Romania’s services trade, the outlook is now radically improving as evidenced by the strongly rebounding services flows and net exports. Nonetheless, the country’s integration into the global economy through services flows continues to remain below its potential.

  14. Integrating into the Global Economy through Services. The Case of Romania

    AGNES GHIBUŢIU

    2014-05-01

    Full Text Available Services represent a most important and dynamic frontier of international trade and investment. The steady expansion of trade in services and its relative resilience in the recent crisis, coupled with its key role in global production networks and its increasing potential in attracting investment provides new opportunities for countries to grow their economies and integrate into the global economy. Drawing on insights from current literature and relying on balance of payments and trade in value-added statistics, this paper examines the main developments shaping Romania’s services trade over the post-crisis years. Its aim is to assess whether the country is seizing the new opportunities arising from services globalization. It finds that following the dramatic crisis-induced decline in the value and performance of Romania’s services trade, the outlook is now radically improving as evidenced by strongly rebounding services flows and net exports. Nonetheless, the country’s integration into the global economy through services flows continues to remain below its potential.

  15. An integrated model for the assessment of global water resources – Part 2: Applications and assessments

    N. Hanasaki

    2008-07-01

    Full Text Available To assess global water resources from the perspective of subannual variation in water availability and water use, an integrated water resources model was developed. In a companion report, we presented the global meteorological forcing input used to drive the model and six modules, namely, the land surface hydrology module, the river routing module, the crop growth module, the reservoir operation module, the environmental flow requirement module, and the anthropogenic withdrawal module. Here, we present the results of the model application and global water resources assessments. First, the timing and volume of simulated agriculture water use were examined because agricultural use composes approximately 85% of total consumptive water withdrawal in the world. The estimated crop calendar showed good agreement with earlier reports for wheat, maize, and rice in major countries of production. In major countries, the error in the planting date was ±1 mo, but there were some exceptional cases. The estimated irrigation water withdrawal also showed fair agreement with country statistics, but tended to be underestimated in countries in the Asian monsoon region. The results indicate the validity of the model and the input meteorological forcing because site-specific parameter tuning was not used in the series of simulations. Finally, global water resources were assessed on a subannual basis using a newly devised index. This index located water-stressed regions that were undetected in earlier studies. These regions, which are indicated by a gap in the subannual distribution of water availability and water use, include the Sahel, the Asian monsoon region, and southern Africa. The simulation results show that the reservoir operations of major reservoirs (>1 km3 and the allocation of environmental flow requirements can alter the population under high water stress by approximately −11% to +5% globally. The integrated model is applicable to

  16. Entropy-based analysis and bioinformatics-inspired integration of global economic information transfer.

    Jinkyu Kim

    Full Text Available The assessment of information transfer in the global economic network helps to understand the current environment and the outlook of an economy. Most approaches on global networks extract information transfer based mainly on a single variable. This paper establishes an entirely new bioinformatics-inspired approach to integrating information transfer derived from multiple variables and develops an international economic network accordingly. In the proposed methodology, we first construct the transfer entropies (TEs between various intra- and inter-country pairs of economic time series variables, test their significances, and then use a weighted sum approach to aggregate information captured in each TE. Through a simulation study, the new method is shown to deliver better information integration compared to existing integration methods in that it can be applied even when intra-country variables are correlated. Empirical investigation with the real world data reveals that Western countries are more influential in the global economic network and that Japan has become less influential following the Asian currency crisis.

  17. Entropy-based analysis and bioinformatics-inspired integration of global economic information transfer.

    Kim, Jinkyu; Kim, Gunn; An, Sungbae; Kwon, Young-Kyun; Yoon, Sungroh

    2013-01-01

    The assessment of information transfer in the global economic network helps to understand the current environment and the outlook of an economy. Most approaches on global networks extract information transfer based mainly on a single variable. This paper establishes an entirely new bioinformatics-inspired approach to integrating information transfer derived from multiple variables and develops an international economic network accordingly. In the proposed methodology, we first construct the transfer entropies (TEs) between various intra- and inter-country pairs of economic time series variables, test their significances, and then use a weighted sum approach to aggregate information captured in each TE. Through a simulation study, the new method is shown to deliver better information integration compared to existing integration methods in that it can be applied even when intra-country variables are correlated. Empirical investigation with the real world data reveals that Western countries are more influential in the global economic network and that Japan has become less influential following the Asian currency crisis.

  18. Innovation in Hungary - The Impact of EU Accession and Integration into Global Value Chains

    Szalavetz Andrea

    2014-11-01

    Full Text Available This paper argues that EU accession has brought about minimal changes in the patterns of innovation in Hungary. The reason why is not that the ‘EU factor’ is of minor importance; rather, it is Hungary's inability to use EU resources effectively, so as to fully benefit from EU membership. The Hungarian story also demonstrates that the EU cannot block member states from reversing reform or abusing the opportunities EU membership offers to them. We contend that globalization (global value chain integration has more effectively contributed to Hungary's knowledge-based upgrading than Europeanization (in the sense of policy transfer; access to EU Structural & Cohesion Funds, and integration in the European Research Area. This argument is substantiated with a case study on innovation strategy design and implementation, which illustrates the ambiguous impact of Europeanization, which is contrasted with our investigation of integration in global value chains, conducted through interviews of foreign-owned manufacturing companies about their R&D-based upgrading experience.

  19. Cellular and molecular mechanisms of HIV-1 integration targeting.

    Engelman, Alan N; Singh, Parmit K

    2018-07-01

    Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior regions of transcriptionally active genes within gene-dense regions of chromatin. The viral capsid interacts with several proteins that are additionally implicated in virus nuclear import, including cleavage and polyadenylation specificity factor 6, to suppress integration into heterochromatin. The viral integrase protein interacts with transcriptional co-activator lens epithelium-derived growth factor p75 to principally position integration within gene bodies. The integrase additionally senses target DNA distortion and nucleotide sequence to help fine-tune the specific phosphodiester bonds that are cleaved at integration sites. Research into virus-host interactions that underlie HIV-1 integration targeting has aided the development of a novel class of integrase inhibitors and may help to improve the safety of viral-based gene therapy vectors.

  20. Integrative Genomics Reveals Mechanisms of Copy Number Alterations Responsible for Transcriptional Deregulation in Colorectal Cancer

    Camps, Jordi; Nguyen, Quang Tri; Padilla-Nash, Hesed M.; Knutsen, Turid; McNeil, Nicole E.; Wangsa, Danny; Hummon, Amanda B.; Grade, Marian; Ried, Thomas; Difilippantonio, Michael J.

    2016-01-01

    To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic hybridization (aCGH), and array-based global gene expression profiling on 31 primary carcinomas and 15 established cell lines. Importantly, aCGH showed that the genomic profiles of primary tumors are recapitulated in the cell lines. We revealed a preponderance of chromosome breakpoints at sites of copy number variants (CNVs) in the CRC cell lines, a novel mechanism of DNA breakage in cancer. The integration of gene expression and aCGH led to the identification of 157 genes localized within high-level copy number changes whose transcriptional deregulation was significantly affected across all of the samples, thereby suggesting that these genes play a functional role in CRC. Genomic amplification at 8q24 was the most recurrent event and led to the overexpression of MYC and FAM84B. Copy number dependent gene expression resulted in deregulation of known cancer genes such as APC, FGFR2, and ERBB2. The identification of only 36 genes whose localization near a breakpoint could account for their observed deregulated expression demonstrates that the major mechanism for transcriptional deregulation in CRC is genomic copy number changes resulting from chromosomal aberrations. PMID:19691111

  1. Integration of molecular pathology, epidemiology and social science for global precision medicine.

    Nishi, Akihiro; Milner, Danny A; Giovannucci, Edward L; Nishihara, Reiko; Tan, Andy S; Kawachi, Ichiro; Ogino, Shuji

    2016-01-01

    The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science.

  2. The response of terrestrial ecosystems to global climate change: Towards an integrated approach

    Rustad, Lindsey E.

    2008-01-01

    Accumulating evidence points to an anthropogenic 'fingerprint' on the global climate change that has occurred in the last century. Climate change has, and will continue to have, profound effects on the structure and function of terrestrial ecosystems. As such, there is a critical need to continue to develop a sound scientific basis for national and international policies regulating carbon sequestration and greenhouse gas emissions. This paper reflects on the nature of current global change experiments, and provides recommendations for a unified multidisciplinary approach to future research in this dynamic field. These recommendations include: (1) better integration between experiments and models, and amongst experimental, monitoring, and space-for-time studies; (2) stable and increased support for long-term studies and multi-factor experiments; (3) explicit inclusion of biodiversity, disturbance, and extreme events in experiments and models; (4) consideration of timing vs intensity of global change factors in experiments and models; (5) evaluation of potential thresholds or ecosystem 'tipping points'; and (6) increased support for model-model and model-experiment comparisons. These recommendations, which reflect discussions within the TERACC international network of global change scientists, will facilitate the unraveling of the complex direct and indirect effects of global climate change on terrestrial ecosystems and their components

  3. Integrating scientific argumentation to improve undergraduate writing and learning in a global environmental change course

    Kreutz, K. J.; Koffman, B. G.; Trenbath, K. L.

    2013-12-01

    What makes a good scientific argument? We began ERS201: Global Environmental Change by asking students to reflect on the mechanics of a strong scientific argument. At the same time, we asked them to evaluate global CO2 and sea level data from different time periods in Earth's history to answer the question, 'Is there a relationship between atmospheric CO2 and sea level, and if so, why?' This question formed the theme for the course, a mid-level, inquiry-based class of about 20 students. Each week, students target specific aspects of the climate system through problem sets, which include experimental and laboratory work, basic statistical analyses of paleoclimate datasets, and the development of simple systems models using STELLA software. Every 2-4 weeks, we challenge students to write short (1500 word) data-driven scientific arguments, which require a synthesis of information from their problem sets and from the scientific literature. Students have to develop a clear, testable hypothesis related to each writing prompt, and then make their case using figures they have generated during the weekly problem sets. We evaluate student writing using a rubric that focuses on the structure and clarity of the argument, relevance of the data included, and integration and quality of the graphics, with a lesser emphasis placed on voice and style. In 2013, student scores improved from a median value of 86 × 9% to 94 × 8% over the course of the semester. More importantly, we found that incorporation of scientific argumentation served to increase student understanding of important and sometimes abstract scientific concepts. For example, on pre- and post-course assessments we asked the question, 'What would happen if a significant portion of the sea ice floating in the Arctic Ocean were to melt?' On the pre-assessment, 80% of students said that it would lead to more coastal flooding, while only 20% correctly stated that a decrease in the reflection of solar energy would lead to

  4. Circuit Mechanisms Governing Local vs. Global Motion Processing in Mouse Visual Cortex

    Rasmussen, Rune; Yonehara, Keisuke

    2017-01-01

    components represented by component direction-selective (CDS) cells. However, how PDS and CDS cells develop their distinct response properties is still unresolved. The visual cortex of the mouse is an attractive model for experimentally solving this issue due to the large molecular and genetic toolbox...... literature on global motion processing based on works in primates and mice. Lastly, we propose what types of experiments could illuminate what circuit mechanisms are governing cortical global visual motion processing. We propose that PDS cells in mouse visual cortex appear as the perfect arena...

  5. Globalization

    Tulio Rosembuj

    2006-12-01

    Full Text Available There is no singular globalization, nor is the result of an individual agent. We could start by saying that global action has different angles and subjects who perform it are different, as well as its objectives. The global is an invisible invasion of materials and immediate effects.

  6. Globalization

    Tulio Rosembuj

    2006-01-01

    There is no singular globalization, nor is the result of an individual agent. We could start by saying that global action has different angles and subjects who perform it are different, as well as its objectives. The global is an invisible invasion of materials and immediate effects.

  7. Integrating place-specific livelihood and equity outcomes into global assessments of bioenergy deployment

    Creutzig, Felix; Corbera, Esteve; Bolwig, Simon; Hunsberger, Carol

    2013-01-01

    Integrated assessment models suggest that the large-scale deployment of bioenergy could contribute to ambitious climate change mitigation efforts. However, such a shift would intensify the global competition for land, with possible consequences for 1.5 billion smallholder livelihoods that these models do not consider. Maintaining and enhancing robust livelihoods upon bioenergy deployment is an equally important sustainability goal that warrants greater attention. The social implications of biofuel production are complex, varied and place-specific, difficult to model, operationalize and quantify. However, a rapidly developing body of social science literature is advancing the understanding of these interactions. In this letter we link human geography research on the interaction between biofuel crops and livelihoods in developing countries to integrated assessments on biofuels. We review case-study research focused on first-generation biofuel crops to demonstrate that food, income, land and other assets such as health are key livelihood dimensions that can be impacted by such crops and we highlight how place-specific and global dynamics influence both aggregate and distributional outcomes across these livelihood dimensions. We argue that place-specific production models and land tenure regimes mediate livelihood outcomes, which are also in turn affected by global and regional markets and their resulting equilibrium dynamics. The place-specific perspective suggests that distributional consequences are a crucial complement to aggregate outcomes; this has not been given enough weight in comprehensive assessments to date. By narrowing the gap between place-specific case studies and global models, our discussion offers a route towards integrating livelihood and equity considerations into scenarios of future bioenergy deployment, thus contributing to a key challenge in sustainability sciences. (letter)

  8. Integrating place-specific livelihood and equity outcomes into global assessments of bioenergy deployment

    Creutzig, Felix; Corbera, Esteve; Bolwig, Simon; Hunsberger, Carol

    2013-09-01

    Integrated assessment models suggest that the large-scale deployment of bioenergy could contribute to ambitious climate change mitigation efforts. However, such a shift would intensify the global competition for land, with possible consequences for 1.5 billion smallholder livelihoods that these models do not consider. Maintaining and enhancing robust livelihoods upon bioenergy deployment is an equally important sustainability goal that warrants greater attention. The social implications of biofuel production are complex, varied and place-specific, difficult to model, operationalize and quantify. However, a rapidly developing body of social science literature is advancing the understanding of these interactions. In this letter we link human geography research on the interaction between biofuel crops and livelihoods in developing countries to integrated assessments on biofuels. We review case-study research focused on first-generation biofuel crops to demonstrate that food, income, land and other assets such as health are key livelihood dimensions that can be impacted by such crops and we highlight how place-specific and global dynamics influence both aggregate and distributional outcomes across these livelihood dimensions. We argue that place-specific production models and land tenure regimes mediate livelihood outcomes, which are also in turn affected by global and regional markets and their resulting equilibrium dynamics. The place-specific perspective suggests that distributional consequences are a crucial complement to aggregate outcomes; this has not been given enough weight in comprehensive assessments to date. By narrowing the gap between place-specific case studies and global models, our discussion offers a route towards integrating livelihood and equity considerations into scenarios of future bioenergy deployment, thus contributing to a key challenge in sustainability sciences.

  9. Challenges and Opportunities for Integrating Social Science Perspectives into Climate and Global Change Assessments

    Larson, E. K.; Li, J.; Zycherman, A.

    2017-12-01

    Integration of social science into climate and global change assessments is fundamental for improving understanding of the drivers, impacts and vulnerability of climate change, and the social, cultural and behavioral challenges related to climate change responses. This requires disciplinary and interdisciplinary knowledge as well as integrational and translational tools for linking this knowledge with the natural and physical sciences. The USGCRP's Social Science Coordinating Committee (SSCC) is tasked with this challenge and is working to integrate relevant social, economic and behavioral knowledge into processes like sustained assessments. This presentation will discuss outcomes from a recent SSCC workshop, "Social Science Perspectives on Climate Change" and their applications to sustained assessments. The workshop brought academic social scientists from four disciplines - anthropology, sociology, geography and archaeology - together with federal scientists and program managers to discuss three major research areas relevant to the USGCRP and climate assessments: (1) innovative tools, methods, and analyses to clarify the interactions of human and natural systems under climate change, (2) understanding of factors contributing to differences in social vulnerability between and within communities under climate change, and (3) social science perspectives on drivers of global climate change. These disciplines, collectively, emphasize the need to consider socio-cultural, political, economic, geographic, and historic factors, and their dynamic interactions, to understand climate change drivers, social vulnerability, and mitigation and adaptation responses. They also highlight the importance of mixed quantitative and qualitative methods to explain impacts, vulnerability, and responses at different time and spatial scales. This presentation will focus on major contributions of the social sciences to climate and global change research. We will discuss future directions for

  10. Quantum mechanics on the half-line using path integrals

    Clark, T.E.; Menikoff, R.; Sharp, D.H.

    1980-01-01

    We study the Feynman path-integral formalism for the constrained problem of a free particle moving on the half-line. It is shown that the effect of the boundary condition at the origin can be incorporated into the path integral by a simple modification of the action. The small-time behavior of the Green's function can be obtained from the stationary-phase evaluation of our expression for the path integral, which in this case includes contributions from both the direct and reflected classical paths

  11. Integrity of Cerebellar Fastigial Nucleus Intrinsic Neurons Is Critical for the Global Ischemic Preconditioning

    Eugene V. Golanov

    2017-09-01

    Full Text Available Excitation of intrinsic neurons of cerebellar fastigial nucleus (FN renders brain tolerant to local and global ischemia. This effect reaches a maximum 72 h after the stimulation and lasts over 10 days. Comparable neuroprotection is observed following sublethal global brain ischemia, a phenomenon known as preconditioning. We hypothesized that FN may participate in the mechanisms of ischemic preconditioning as a part of the intrinsic neuroprotective mechanism. To explore potential significance of FN neurons in brain ischemic tolerance we lesioned intrinsic FN neurons with excitotoxin ibotenic acid five days before exposure to 20 min four-vessel occlusion (4-VO global ischemia while analyzing neuronal damage in Cornu Ammoni area 1 (CA1 hippocampal area one week later. In FN-lesioned animals, loss of CA1 cells was higher by 22% compared to control (phosphate buffered saline (PBS-injected animals. Moreover, lesion of FN neurons increased morbidity following global ischemia by 50%. Ablation of FN neurons also reversed salvaging effects of five-minute ischemic preconditioning on CA1 neurons and morbidity, while ablation of cerebellar dentate nucleus neurons did not change effect of ischemic preconditioning. We conclude that FN is an important part of intrinsic neuroprotective system, which participates in ischemic preconditioning and may participate in naturally occurring neuroprotection, such as “diving response”.

  12. Stock return predictability and market integration: The role of global and local information

    David G. McMillan

    2016-12-01

    Full Text Available This paper examines the predictability of a range of international stock markets where we allow the presence of both local and global predictive factors. Recent research has argued that US returns have predictive power for international stock returns. We expand this line of research, following work on market integration, to include a more general definition of the global factor, based on principal components analysis. Results identify three global expected returns factors, one related to the major stock markets of the US, UK and Asia and one related to the other markets analysed. The third component is related to dividend growth. A single dominant realised returns factor is also noted. A forecasting exercise comparing the principal components based factors to a US return factor and local market only factors, as well as the historical mean benchmark finds supportive evidence for the former approach. It is hoped that the results from this paper will be informative on three counts. First, to academics interested in understanding the dynamics asset price movement. Second, to market participants who aim to time the market and engage in portfolio and risk management. Third, to those (policy makers and others who are interested in linkages across international markets and the nature and degree of integration.

  13. Global identification predicts gay-male identity integration and well-being among Turkish gay men.

    Koc, Yasin; Vignoles, Vivian L

    2016-12-01

    In most parts of the world, hegemonic masculinity requires men to endorse traditional masculine ideals, one of which is rejection of homosexuality. Wherever hegemonic masculinity favours heterosexuality over homosexuality, gay males may feel under pressure to negotiate their conflicting male gender and gay sexual identities to maintain positive self-perceptions. However, globalization, as a source of intercultural interaction, might provide a beneficial context for people wishing to create alternative masculinities in the face of hegemonic masculinity. Hence, we tested if global identification would predict higher levels of gay-male identity integration, and indirectly subjective well-being, via alternative masculinity representations for gay and male identities. A community sample of 219 gay and bisexual men from Turkey completed the study. Structural equation modelling revealed that global identification positively predicted gay-male identity integration, and indirectly subjective well-being; however, alternative masculinity representations did not mediate this relationship. Our findings illustrate how identity categories in different domains can intersect and affect each other in complex ways. Moreover, we discuss mental health and well-being implications for gay men living in cultures where they experience high levels of prejudice and stigma. © 2016 The British Psychological Society.

  14. Physical mechanisms of spring and summertime drought related with the global warming over the northern America

    Choi, W.; Kim, K. Y.

    2017-12-01

    Drought during the growing season (spring through summer) is severe natural hazard in the large cropland over the northern America. It is important to understand how the drought is related with the global warming and how it will change in the future. This study aims to investigate the physical mechanism of global warming impact on the spring and summertime drought over the northern America using Cyclostationary Empirical Orthogonal Function (CSEOF) analysis. The Northern Hemisphere surface warming, the most dominant mode of the surface air temperature, has resulted in decreased relative humidity and precipitation over the mid-latitude region of North America. For the viewpoint of atmospheric water demand, soil moisture and evaporation have also decreased significantly, exacerbating vulnerability of drought. These consistent features of changes in water demand and supply related with the global warming can provide a possibility of credible insight for future drought change.

  15. The Mechanism of Russian Nanoindustry Development Caused by Globalization: Methods and Tools

    Avtonomova Oksana Alekseevna

    2015-05-01

    Full Text Available Establishing the effective mechanism of the Russian nanoindustry functioning by means of globalization benefits is one of the most important factors of raising the national economy competitiveness in the context of transition to a new technological way. Nanotechnologies is one of the key factors of this new way. The mechanism of nanoindustrial development of the Russian Federation caused by globalization is characterized in the article as a way of task-oriented implementation and management of the global nanotechnology industry development on the basis of cooperation of entities at different levels of the global economic system using the appropriate methods, tools, resources and communication channels, factors and capitals. The mechanism aims at adjusting the described contradictions faced by Russian entities in their business activities in the sphere of production, consumption and promotion of nanotechnologies, nanogoods and nanoservices. Within the framework of a theoretical research the author proposes the classification of methods and tools for the development of the Russian nanoindustry through the international cooperation by the criteria of economic functions: planning, institution, organization, management, investment, finance, information, analysis, control – all aimed at promoting the unification of concepts and actions of collaborating entities in the sphere of nanotechnology. The developed methodology of the international nanoindustrial interaction of Russian entities includes the result-oriented, institutional, organizational, budgetary, investment, tax, informative, and administrative methods, as well as analysis, audit, accounting and evaluation. Besides, the article proves the feasibility of marketing tools application in the sphere of nanoindustrial cooperation aimed at developing a more efficient strategy of promoting products with nanofeatures to the global market.

  16. In vitro analysis of integrated global high-resolution DNA methylation profiling with genomic imbalance and gene expression in osteosarcoma.

    Bekim Sadikovic

    Full Text Available Genetic and epigenetic changes contribute to deregulation of gene expression and development of human cancer. Changes in DNA methylation are key epigenetic factors regulating gene expression and genomic stability. Recent progress in microarray technologies resulted in developments of high resolution platforms for profiling of genetic, epigenetic and gene expression changes. OS is a pediatric bone tumor with characteristically high level of numerical and structural chromosomal changes. Furthermore, little is known about DNA methylation changes in OS. Our objective was to develop an integrative approach for analysis of high-resolution epigenomic, genomic, and gene expression profiles in order to identify functional epi/genomic differences between OS cell lines and normal human osteoblasts. A combination of Affymetrix Promoter Tilling Arrays for DNA methylation, Agilent array-CGH platform for genomic imbalance and Affymetrix Gene 1.0 platform for gene expression analysis was used. As a result, an integrative high-resolution approach for interrogation of genome-wide tumour-specific changes in DNA methylation was developed. This approach was used to provide the first genomic DNA methylation maps, and to identify and validate genes with aberrant DNA methylation in OS cell lines. This first integrative analysis of global cancer-related changes in DNA methylation, genomic imbalance, and gene expression has provided comprehensive evidence of the cumulative roles of epigenetic and genetic mechanisms in deregulation of gene expression networks.

  17. Hybrid extended particle filter (HEPF) for integrated inertial navigation and global positioning systems

    Aggarwal, Priyanka; Syed, Zainab; El-Sheimy, Naser

    2009-01-01

    Navigation includes the integration of methodologies and systems for estimating time-varying position, velocity and attitude of moving objects. Navigation incorporating the integrated inertial navigation system (INS) and global positioning system (GPS) generally requires extensive evaluations of nonlinear equations involving double integration. Currently, integrated navigation systems are commonly implemented using the extended Kalman filter (EKF). The EKF assumes a linearized process, measurement models and Gaussian noise distributions. These assumptions are unrealistic for highly nonlinear systems like land vehicle navigation and may cause filter divergence. A particle filter (PF) is developed to enhance integrated INS/GPS system performance as it can easily deal with nonlinearity and non-Gaussian noises. In this paper, a hybrid extended particle filter (HEPF) is developed as an alternative to the well-known EKF to achieve better navigation data accuracy for low-cost microelectromechanical system sensors. The results show that the HEPF performs better than the EKF during GPS outages, especially when simulated outages are located in periods with high vehicle dynamics

  18. INTEGRATING COUNTRY-SPECIFIC CULTURE IN THE BRANDING STRATEGY FOR BUILDING GLOBAL SUCCESS

    Alexandra IOANID

    2014-11-01

    Full Text Available A strong brand is the one that integrates its cultural origins and values with the cultural values of the countries where it operates, building relationships based on trust with the local consumers. The chances for a company to gain share market when starting operations in a new country grows a lot if the management allows enough regional flexibility on how the brands are marketed, according to the cultural characteristics of the potential local customers. In the actual globalized business environment, the brand marketer has the choice to adopt a global or a local approach in the marketing strategy, that most of the times determines the success or the failure of the business in a specific country. An important challenge for any marketer is the integration of the brand-culture with the country-culture and in this context, the paper analyses different cultures and offers some branding strategies valid for both products and services. This paper aims to demonstrate the importance of the country-specific culture integration in the marketing strategy of a company for growing the effectiveness of all its operations. The ideas mentioned in this paper are based on literature research and also on authors’ experience with multicultural environments.

  19. An integrated model to simulate sown area changes for major crops at a global scale

    SHIBASAKI; Ryosuke

    2008-01-01

    Dynamics of land use systems have attracted much attention from scientists around the world due to their ecological and socio-economic implications. An integrated model to dynamically simulate future changes in sown areas of four major crops (rice, maize, wheat and soybean) on a global scale is pre- sented. To do so, a crop choice model was developed on the basis of Multinomial Logit (Logit) model to model land users’ decisions on crop choices among a set of available alternatives with using a crop utility function. A GIS-based Environmental Policy Integrated Climate (EPIC) model was adopted to simulate the crop yields under a given geophysical environment and farming management conditions, while the International Food Policy and Agricultural Simulation (IFPSIM) model was utilized to estimate crop price in the international market. The crop choice model was linked with the GIS-based EPIC model and the IFPSIM model through data exchange. This integrated model was then validated against the FAO statistical data in 2001-2003 and the Moderate Resolution Imaging Spectroradiometer (MODIS) global land cover product in 2001. Both validation approaches indicated reliability of the model for ad- dressing the dynamics in agricultural land use and its capability for long-term scenario analysis. Finally, the model application was designed to run over a time period of 30 a, taking the year 2000 as baseline. The model outcomes can help understand and explain the causes, locations and consequences of land use changes, and provide support for land use planning and policy making.

  20. Improving Remote Sensing Scene Classification by Integrating Global-Context and Local-Object Features

    Dan Zeng

    2018-05-01

    Full Text Available Recently, many researchers have been dedicated to using convolutional neural networks (CNNs to extract global-context features (GCFs for remote-sensing scene classification. Commonly, accurate classification of scenes requires knowledge about both the global context and local objects. However, unlike the natural images in which the objects cover most of the image, objects in remote-sensing images are generally small and decentralized. Thus, it is hard for vanilla CNNs to focus on both global context and small local objects. To address this issue, this paper proposes a novel end-to-end CNN by integrating the GCFs and local-object-level features (LOFs. The proposed network includes two branches, the local object branch (LOB and global semantic branch (GSB, which are used to generate the LOFs and GCFs, respectively. Then, the concatenation of features extracted from the two branches allows our method to be more discriminative in scene classification. Three challenging benchmark remote-sensing datasets were extensively experimented on; the proposed approach outperformed the existing scene classification methods and achieved state-of-the-art results for all three datasets.

  1. Wastewater Treatment Energy Recovery Potential For Adaptation To Global Change: An Integrated Assessment

    Breach, Patrick A.; Simonovic, Slobodan P.

    2018-04-01

    Approximately 20% of wastewaters globally do not receive treatment, whereas wastewater discharges are projected to increase, thereby leading to excessive water quality degradation of surface waters on a global scale. Increased treatment could help alleviate water quality issues by constructing more treatment plants; however, in many areas there exist economic constraints. Energy recovery methods including the utilization of biogas and incineration of biosolids generated during the treatment process may help to alleviate treatment costs. This study explores the potential for investments in energy recovery from wastewater to increase treatment levels and thus improve surface water quality. This was done by examining the relationships between nutrient over-enrichment, wastewater treatment, and energy recovery at a global scale using system dynamics simulation as part of the ANEMI integrated assessment model. The results show that a significant amount of energy can be recovered from wastewater, which helps to alleviate some of the costs of treatment. It was found that wastewater treatment levels could be increased by 34%, helping to offset the higher nutrient loading from a growing population with access to improved sanitation. The production of renewable natural gas from biogas was found to have the potential to prolong the depletion of natural gas resources used to produce electricity and heat. It is recommended that agricultural nutrient discharges be better managed to help reduce nutrient over-enrichment on global scale. To increase the utility of the simulation, a finer spatial scale should be used to consider regional treatment, economic, and water quality characteristics.

  2. Mechanical Integrity of Copper Canister Lid and Cylinder

    Karlsson, Marianne

    2002-01-01

    This report compiles finite element analyses performed to ensure the structural integrity of canisters used for storing of nuclear fuel waste of type BWR. The report comprises analyses performed on the canister lid and cylinder casing in order to determine static and long-term strength of the structure. The report analyses the mechanical response of the lid and flange of the copper canister when subjected to loads caused by pressure from swelling bentonite and from ground water at a depth of 500 meter. The loads acting on the canister are somewhat uncertain and the cases investigated in this report are possible cases. Load cases analysed are: Pressure 15 MPa uniformly distributed on lid and 5 MPa uniformly distributed on cylinder; Pressure 5 MPa uniformly distributed on lid and 15 MPa uniformly distributed on cylinder; Pressure 20 MPa uniformly distributed on lid and cylinder; Side pressures 10 MPa and 20 MPa uniformly distributed on part of the cylinder. Creep analyses are also performed in order to estimate the stresses that will arise when the canister is placed in the repository. The analyses in this report are recreated from the original analyses but the models differ in geometry. Also, there is no information in the original reports on material data, time-independent as well as creep data, and analysis procedure. The data used in the recreated analyses are based on information from References 2, 3, 6 and 7. The results presented in this report are based on the supplementary analyses. These results differ from the original results. Most likely this is due to differences in model geometry. The original results are appended to the report and are summarised for comparison with results from the supplementary analyses. Otherwise, these results are not further discussed. For all load cases, high tensile stresses are found in the lid fillet between the planar part and the flange. High tensile stresses are also found in the weld surface and on the outer side of the

  3. Globalization

    Andru?cã Maria Carmen

    2013-01-01

    The field of globalization has highlighted an interdependence implied by a more harmonious understanding determined by the daily interaction between nations through the inducement of peace and the management of streamlining and the effectiveness of the global economy. For the functioning of the globalization, the developing countries that can be helped by the developed ones must be involved. The international community can contribute to the institution of the development environment of the gl...

  4. Global Positioning System (GPS) Receiver Autonomous Integrity Monitoring (RAIM) web service to support Area Navigation (RNAV) flight planning

    2008-01-28

    The Volpe Center designed, implemented, and deployed a Global Positioning System (GPS) Receiver Autonomous Integrity Monitoring (RAIM) prediction system in the mid 1990s to support both Air Force and Federal Aviation Administration (FAA) use of TSO C...

  5. Integrating remote sensing, geographic information systems and global positioning system techniques with hydrological modeling

    Thakur, Jay Krishna; Singh, Sudhir Kumar; Ekanthalu, Vicky Shettigondahalli

    2017-07-01

    Integration of remote sensing (RS), geographic information systems (GIS) and global positioning system (GPS) are emerging research areas in the field of groundwater hydrology, resource management, environmental monitoring and during emergency response. Recent advancements in the fields of RS, GIS, GPS and higher level of computation will help in providing and handling a range of data simultaneously in a time- and cost-efficient manner. This review paper deals with hydrological modeling, uses of remote sensing and GIS in hydrological modeling, models of integrations and their need and in last the conclusion. After dealing with these issues conceptually and technically, we can develop better methods and novel approaches to handle large data sets and in a better way to communicate information related with rapidly decreasing societal resources, i.e. groundwater.

  6. Integration of Biodiversity Databases in Taiwan and Linkage to Global Databases

    Kwang-Tsao Shao

    2007-03-01

    Full Text Available The biodiversity databases in Taiwan were dispersed to various institutions and colleges with limited amount of data by 2001. The Natural Resources and Ecology GIS Database sponsored by the Council of Agriculture, which is part of the National Geographic Information System planned by the Ministry of Interior, was the most well established biodiversity database in Taiwan. But thisThis database was, however, mainly collectingcollected the distribution data of terrestrial animals and plants within the Taiwan area. In 2001, GBIF was formed, and Taiwan joined as one of the an Associate Participant and started, starting the establishment and integration of animal and plant species databases; therefore, TaiBIF was able to co-operate with GBIF. The information of Catalog of Life, specimens, and alien species were integrated by the Darwin core. The standard. These metadata standards allowed the biodiversity information of Taiwan to connect with global databases.

  7. A Short Tutorial on Inertial Navigation System and Global Positioning System Integration

    Smalling, Kyle M.; Eure, Kenneth W.

    2015-01-01

    The purpose of this document is to describe a simple method of integrating Inertial Navigation System (INS) information with Global Positioning System (GPS) information for an improved estimate of vehicle attitude and position. A simple two dimensional (2D) case is considered. The attitude estimates are derived from sensor data and used in the estimation of vehicle position and velocity through dead reckoning within the INS. The INS estimates are updated with GPS estimates using a Kalman filter. This tutorial is intended for the novice user with a focus on bringing the reader from raw sensor measurements to an integrated position and attitude estimate. An application is given using a remotely controlled ground vehicle operating in assumed 2D environment. The theory is developed first followed by an illustrative example.

  8. Business integration unit (BIU adapter for industrial global value chain on the web

    Adel Ghannam

    2016-05-01

    Full Text Available Today's manufacturing enterprises rarely live in isolation. They need to be connected in order to create products from which a group of enterprises, called global-value-chain (GVC, can derive value. Service-oriented architecture (SOA and event-driven architecture (EDA are two different paradigms that address complex integration challenges. Enterprise service bus (ESB allows for the implementation of both the SOA and the EDA concepts. This paper addresses the development of an enterprise service bus (ESB to grant the operation of GVC. A proposed business-integrator-unit (BIU is designed to be plugged in each enterprise system. The BIU contains a “business collaboration map configurator” that allows real time allocation of roles to members’ enterprises.

  9. Electrostatic microactuators with integrated gear linkages for mechanical power transmission

    Legtenberg, R.; Legtenberg, Rob; Berenschot, Johan W.; Elwenspoek, Michael Curt; Fluitman, J.H.J.

    1996-01-01

    In this paper a surface micromachining process is presented which has been used to fabricate electrostatic microactuators that are interconnected with each other and linked to other movable microstructures by integrated gear linkages. The gear linkages consist of rotational and linear gear

  10. Integration of Molecular Pathology, Epidemiology, and Social Science for Global Precision Medicine

    Nishi, Akihiro; Milner, Danny A; Giovannucci, Edward L.; Nishihara, Reiko; Tan, Andy S.; Kawachi, Ichiro; Ogino, Shuji

    2015-01-01

    Summary The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations, and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial, and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors, and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference, and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology, and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors, and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging, and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science. PMID:26636627

  11. A mechanism for land-ocean contrasts in global monsoon trends in a warming climate

    Fasullo, J. [National Center for Atmospheric Research, CAS/NCAR, Boulder, CO (United States)

    2012-09-15

    A central paradox of the global monsoon record involves reported decreases in rainfall over land during an era in which the global hydrologic cycle is both expected and observed to intensify. It is within this context that this work develops a physical basis for both interpreting the observed record and anticipating changes in the monsoons in a warming climate while bolstering the concept of the global monsoon in the context of shared feedbacks. The global-land monsoon record across multiple reanalyses is first assessed. Trends that in other studies have been taken as real are shown to likely be spurious as a result of changes in the assimilated data streams both prior to and during the satellite era. Nonetheless, based on satellite estimates, robust increases in monsoon rainfall over ocean do exist and a physical basis for this land-ocean contrast remains lacking. To address the contrast's causes, simulated trends are therefore assessed. While projections of total rainfall are inconsistent across models, the robust land-ocean contrast identified in observations is confirmed. A feedback mechanism is proposed rooted in the facts that land areas warm disproportionately relative to ocean, and onshore flow is the chief source of monsoonal moisture. Reductions in lower tropospheric relative humidity over land domains are therefore inevitable and these have direct consequences for the monsoonal convective environment including an increase in the lifting condensation level and a shift in the distribution of convection generally towards less frequent and potentially more intense events. The mechanism is interpreted as an important modulating influence on the ''rich-get-richer'' mechanism. Caveats for regional monsoons exist and are discussed. (orig.)

  12. Method of mechanical quadratures for solving singular integral equations of various types

    Sahakyan, A. V.; Amirjanyan, H. A.

    2018-04-01

    The method of mechanical quadratures is proposed as a common approach intended for solving the integral equations defined on finite intervals and containing Cauchy-type singular integrals. This method can be used to solve singular integral equations of the first and second kind, equations with generalized kernel, weakly singular equations, and integro-differential equations. The quadrature rules for several different integrals represented through the same coefficients are presented. This allows one to reduce the integral equations containing integrals of different types to a system of linear algebraic equations.

  13. Global collapse and J integral analysis for inner-diameter defected curved plates in tension

    Hertelé, Stijn; Verstraete, Matthias; Denys, Rudi; De Waele, Wim

    2013-01-01

    Reference stress equations are widely used to predict both the limit load and the J integral response of defected structures. Their validity is key to performing a safe assessment of structural integrity (plastic collapse and fracture). An analytical reference stress equation based upon global collapse has recently been developed for curved plates with a part-through defect located at the inner diameter surface. This equation predicts decreasing reference stress values as plate curvature increases. To qualify the predictions, the authors have performed a series of finite element analyses covering a wide range of possible geometries. This paper compares the numerically obtained limit loads and J integral responses with the analytical predictions of the reference stress equation. The finite element results generally confirm the decrease of reference stress with increasing plate curvature. Highly pronounced differences may occur between flat plates and slightly curved plates. Overall, the analytically predicted decrease in reference stress is overestimated for small defects but is representative for larger defects. -- Highlights: • A reference stress equation for inner-diameter defected curved plates in tension was developed earlier. • The equation predicts a lower reference stress as plate curvature increases. • The analytical predictions are validated through finite element analysis. • Collapse and J integral are insensitive to curvature for small defects. • For large defects, the analytically predicted trend is confirmed

  14. GTSO: Global Trace Synchronization and Ordering Mechanism for Wireless Sensor Network Monitoring Platforms

    Bonastre, Alberto; Ors, Rafael

    2017-01-01

    Monitoring is one of the best ways to evaluate the behavior of computer systems. When the monitored system is a distributed system—such as a wireless sensor network (WSN)—the monitoring operation must also be distributed, providing a distributed trace for further analysis. The temporal sequence of occurrence of the events registered by the distributed monitoring platform (DMP) must be correctly established to provide cause-effect relationships between them, so the logs obtained in different monitor nodes must be synchronized. Many of synchronization mechanisms applied to DMPs consist in adjusting the internal clocks of the nodes to the same value as a reference time. However, these mechanisms can create an incoherent event sequence. This article presents a new method to achieve global synchronization of the traces obtained in a DMP. It is based on periodic synchronization signals that are received by the monitor nodes and logged along with the recorded events. This mechanism processes all traces and generates a global post-synchronized trace by scaling all times registered proportionally according with the synchronization signals. It is intended to be a simple but efficient offline mechanism. Its application in a WSN-DMP demonstrates that it guarantees a correct ordering of the events, avoiding the aforementioned issues. PMID:29295494

  15. GTSO: Global Trace Synchronization and Ordering Mechanism for Wireless Sensor Network Monitoring Platforms.

    Navia, Marlon; Campelo, José Carlos; Bonastre, Alberto; Ors, Rafael

    2017-12-23

    Monitoring is one of the best ways to evaluate the behavior of computer systems. When the monitored system is a distributed system-such as a wireless sensor network (WSN)-the monitoring operation must also be distributed, providing a distributed trace for further analysis. The temporal sequence of occurrence of the events registered by the distributed monitoring platform (DMP) must be correctly established to provide cause-effect relationships between them, so the logs obtained in different monitor nodes must be synchronized. Many of synchronization mechanisms applied to DMPs consist in adjusting the internal clocks of the nodes to the same value as a reference time. However, these mechanisms can create an incoherent event sequence. This article presents a new method to achieve global synchronization of the traces obtained in a DMP. It is based on periodic synchronization signals that are received by the monitor nodes and logged along with the recorded events. This mechanism processes all traces and generates a global post-synchronized trace by scaling all times registered proportionally according with the synchronization signals. It is intended to be a simple but efficient offline mechanism. Its application in a WSN-DMP demonstrates that it guarantees a correct ordering of the events, avoiding the aforementioned issues.

  16. Plant communities as drivers of soil respiration: pathways, mechanisms, and significance for global change

    D. B. Metcalfe

    2011-08-01

    Full Text Available Understanding the impacts of plant community characteristics on soil carbon dioxide efflux (R is a key prerequisite for accurate prediction of the future carbon (C balance of terrestrial ecosystems under climate change. However, developing a mechanistic understanding of the determinants of R is complicated by the presence of multiple different sources of respiratory C within soil – such as soil microbes, plant roots and their mycorrhizal symbionts – each with their distinct dynamics and drivers. In this review, we synthesize relevant information from a wide spectrum of sources to evaluate the current state of knowledge about plant community effects on R, examine how this information is incorporated into global climate models, and highlight priorities for future research. Despite often large variation amongst studies and methods, several general trends emerge.

    Mechanisms whereby plants affect R may be grouped into effects on belowground C allocation, aboveground litter properties and microclimate. Within vegetation types, the amount of C diverted belowground, and hence R, may be controlled mainly by the rate of photosynthetic C uptake, while amongst vegetation types this should be more dependent upon the specific C allocation strategies of the plant life form. We make the case that plant community composition, rather than diversity, is usually the dominant control on R in natural systems. Individual species impacts on R may be largest where the species accounts for most of the biomass in the ecosystem, has very distinct traits to the rest of the community and/or modulates the occurrence of major natural disturbances. We show that climate vegetation models incorporate a number of pathways whereby plants can affect R, but that simplifications regarding allocation schemes and drivers of litter decomposition may limit model accuracy. We also suggest that under a warmer future

  17. The global Filipino nurse: An integrative review of Filipino nurses' work experiences.

    Montayre, Jed; Montayre, Jasmine; Holroyd, Eleanor

    2018-05-01

    To understand the work-related experiences of Philippine-trained nurses working globally. The Philippines is a major source country of foreign-trained nurses located globally. However, there is paucity of research on professional factors and career related issues affecting foreign-trained nurses' work experiences. An integrative review through a comprehensive search of literature was undertaken from November 2015 and was repeated in August 2016. Seven articles satisfied the selection criteria. Filipino nurses experienced differences in the practice of nursing in terms of work process, roles and autonomy. Moreover, they encountered challenges such as work-related discrimination and technical difficulties within the organisation. A clear understanding of Filipino nurses' work experiences and the challenges they have encountered suggests identification of important constructs influencing effective translation of nursing practice across cultures and health systems, which then form the basis for support strategies. It is critical to recognize foreign-trained nurses' experience of work-related differences and challenges as these foster favorable conditions for the management team to plan and continually evaluate policies around recruitment, retention and support offered to these nurses. Furthermore, findings suggest internationalization of nursing framework and standards integrating a transcultural paradigm among staff members within a work organisation. © 2017 John Wiley & Sons Ltd.

  18. Dynamics of global vegetation biomass simulated by the integrated Earth System Model

    Mao, J.; Shi, X.; Di Vittorio, A. V.; Thornton, P. E.; Piao, S.; Yang, X.; Truesdale, J. E.; Bond-Lamberty, B. P.; Chini, L. P.; Thomson, A. M.; Hurtt, G. C.; Collins, W.; Edmonds, J.

    2014-12-01

    The global vegetation biomass stores huge amounts of carbon and is thus important to the global carbon budget (Pan et al., 2010). For the past few decades, different observation-based estimates and modeling of biomass in the above- and below-ground vegetation compartments have been comprehensively conducted (Saatchi et al., 2011; Baccini et al., 2012). However, uncertainties still exist, in particular for the simulation of biomass magnitude, tendency, and the response of biomass to climatic conditions and natural and human disturbances. The recently successful coupling of the integrated Earth System Model (iESM) (Di Vittorio et al., 2014; Bond-Lamberty et al., 2014), which links the Global Change Assessment Model (GCAM), Global Land-use Model (GLM), and Community Earth System Model (CESM), offers a great opportunity to understand the biomass-related dynamics in a fully-coupled natural and human modeling system. In this study, we focus on the systematic analysis and evaluation of the iESM simulated historical (1850-2005) and future (2006-2100) biomass changes and the response of the biomass dynamics to various impact factors, in particular the human-induced Land Use/Land Cover Change (LULCC). By analyzing the iESM simulations with and without the interactive LULCC feedbacks, we further study how and where the climate feedbacks affect socioeconomic decisions and LULCC, such as to alter vegetation carbon storage. References Pan Y et. al: A large and persistent carbon sink in the World's forests. Science 2011, 333:988-993. Saatchi SS et al: Benchmark map of forest carbon stocks in tropical regions across three continents. Proc Natl Acad Sci 2011, 108:9899-9904. Baccini A et al: Estimated carbon dioxide emissions from tropical deforestation improved by carbon-density maps. Nature Clim Change 2012, 2:182-185. Di Vittorio AV et al: From land use to land cover: restoring the afforestation signal in a coupled integrated assessment-earth system model and the implications for

  19. Process Improvement Through Tool Integration in Aero-Mechanical Design

    Briggs, Clark

    2010-01-01

    Emerging capabilities in commercial design tools promise to significantly improve the multi-disciplinary and inter-disciplinary design and analysis coverage for aerospace mechanical engineers. This paper explores the analysis process for two example problems of a wing and flap mechanical drive system and an aircraft landing gear door panel. The examples begin with the design solid models and include various analysis disciplines such as structural stress and aerodynamic loads. Analytical methods include CFD, multi-body dynamics with flexible bodies and structural analysis. Elements of analysis data management, data visualization and collaboration are also included.

  20. On the integration developmental characteristics as a form of international policy in the context of modern globalization processes

    Bostan Sergii Ivanovich

    2014-12-01

    Full Text Available Under globalization of the world community, there are new opportunities and potential threats to the current system of international relations, collective security and geopolitical development of different regions. Integration and regionalization, consolidation and separatism entered upon the agenda of the political present. The integration process becomes one of the variations of peaceful and mutually beneficial solution to the question of the globalization influence of uneven development of the world regions, the fight against global problems of humanity, discrimination and intolerance, spread the values of democracy, rights, freedom and equality.

  1. An integrated model to simulate sown area changes for major crops at a global scale

    WU WenBin; YANG Peng; MENG ChaoYing; SHIBASAKI Ryosuke; ZHOU QingBo; TANG HuaJun; SHI Yun

    2008-01-01

    Dynamics of land use systems have attracted much attention from scientists around the world due to their ecological and socio-economic implications. An integrated model to dynamically simulate future changes in sown areas of four major crops (rice, maize, wheat and soybean) on a global scale is presented. To do so, a crop choice model was developed on the basis of Multinomial Logit (Logit) model to model land users' decisions on crop choices among a set of available alternatives with using a crop utility function. A GIS-based Environmental Policy Integrated Climate (EPIC) model was adopted to simulate the crop yields under a given geophysical environment and farming management conditions,while the International Food Policy and Agricultural Simulation (IFPSIM) model was utilized to estimate crop price in the international market. The crop choice model was linked with the GIS-based EPIC model and the IFPSIM model through data exchange. This integrated model was then validated against the FAO statistical data in 2001-2003 and the Moderate Resolution Imaging Spectroradiometer (MODIS)global land cover product in 2001. Both validation approaches indicated reliability of the model for addressing the dynamics in agricultural land use and its capability for long-term scenario analysis. Finally,the model application was designed to run over a time period of 30 a, taking the year 2000 as baseline.The model outcomes can help understand and explain the causes, locations and consequences of land use changes, and provide support for land use planning and policy making.

  2. An Improved Global Wind Resource Estimate for Integrated Assessment Models: Preprint

    Eurek, Kelly [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sullivan, Patrick [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gleason, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hettinger, Dylan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Heimiller, Donna [National Renewable Energy Lab. (NREL), Golden, CO (United States); Lopez, Anthony [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-02-01

    This paper summarizes initial steps to improving the robustness and accuracy of global renewable resource and techno-economic assessments for use in integrated assessment models. We outline a method to construct country-level wind resource supply curves, delineated by resource quality and other parameters. Using mesoscale reanalysis data, we generate estimates for wind quality, both terrestrial and offshore, across the globe. Because not all land or water area is suitable for development, appropriate database layers provide exclusions to reduce the total resource to its technical potential. We expand upon estimates from related studies by: using a globally consistent data source of uniquely detailed wind speed characterizations; assuming a non-constant coefficient of performance for adjusting power curves for altitude; categorizing the distance from resource sites to the electric power grid; and characterizing offshore exclusions on the basis of sea ice concentrations. The product, then, is technical potential by country, classified by resource quality as determined by net capacity factor. Additional classifications dimensions are available, including distance to transmission networks for terrestrial wind and distance to shore and water depth for offshore. We estimate the total global wind generation potential of 560 PWh for terrestrial wind with 90% of resource classified as low-to-mid quality, and 315 PWh for offshore wind with 67% classified as mid-to-high quality. These estimates are based on 3.5 MW composite wind turbines with 90 m hub heights, 0.95 availability, 90% array efficiency, and 5 MW/km2 deployment density in non-excluded areas. We compare the underlying technical assumption and results with other global assessments.

  3. Integrating Unified Gravity Wave Physics into the NOAA Next Generation Global Prediction System

    Alpert, J. C.; Yudin, V.; Fuller-Rowell, T. J.; Akmaev, R. A.

    2017-12-01

    The Unified Gravity Wave Physics (UGWP) project for the Next Generation Global Prediction System (NGGPS) is a NOAA collaborative effort between the National Centers for Environmental Prediction (NCEP), Environemntal Modeling Center (EMC) and the University of Colorado, Cooperative Institute for Research in Environmental Sciences (CU-CIRES) to support upgrades and improvements of GW dynamics (resolved scales) and physics (sub-grid scales) in the NOAA Environmental Modeling System (NEMS)†. As envisioned the global climate, weather and space weather models of NEMS will substantially improve their predictions and forecasts with the resolution-sensitive (scale-aware) formulations planned under the UGWP framework for both orographic and non-stationary waves. In particular, the planned improvements for the Global Forecast System (GFS) model of NEMS are: calibration of model physics for higher vertical and horizontal resolution and an extended vertical range of simulations, upgrades to GW schemes, including the turbulent heating and eddy mixing due to wave dissipation and breaking, and representation of the internally-generated QBO. The main priority of the UGWP project is unified parameterization of orographic and non-orographic GW effects including momentum deposition in the middle atmosphere and turbulent heating and eddies due to wave dissipation and breaking. The latter effects are not currently represented in NOAA atmosphere models. The team has tested and evaluated four candidate GW solvers integrating the selected GW schemes into the NGGPS model. Our current work and planned activity is to implement the UGWP schemes in the first available GFS/FV3 (open FV3) configuration including adapted GFDL modification for sub-grid orography in GFS. Initial global model results will be shown for the operational and research GFS configuration for spectral and FV3 dynamical cores. †http://www.emc.ncep.noaa.gov/index.php?branch=NEMS

  4. Reconciling uncertainties in integrated science and policy models: Applications to global climate change

    Kandlikar, Milind [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    1994-12-01

    In this thesis tools of data reconciliation are used to integrate available information into scientific and policy models of greenhouse gases. The role of uncertainties in scientific and policy models of global climate change is examined, and implications for global change policy are drawn. Methane is the second most important greenhouse gas. Global sources and sinks of methane have significant uncertainties. A chance constrained methodology was developed and used to perform inversions on the global methane cycle. Budgets of methane that are consistent with source fluxes, isotopic and ice core measurements were determined. While it is not possible to come up with a single budget for CH{sub 4}, performing the calculation with a number of sets of assumed priors suggests a convergence in the allowed range for sources. In some cases -- wetlands (70-130 Tg/yr), rice paddies (60-125 Tg/yr) a significant reduction in the uncertainty of the source estimate is achieved. Our results compare favorably with the most recent measurements of flux estimates. For comparison, a similar analysis using bayes monte carlo simulation was performed. The question of the missing sink for carbon remains unresolved. Two analyses that attempt to quantify the missing sink were performed. First, a steady state analysis of the carbon cycle was used to determine the pre-industrial inter-hemispheric carbon concentration gradient. Second, a full blown dynamic inversion of the carbon cycle was performed. An advection diffusion ocean model with surface chemistry, coupled to box models of the atmosphere and the biosphere was inverted to fit available measurements of {sup 12}C and {sup 14}C carbon isotopes using Differential-Algebraic Optimization. The model effectively suggests that the {open_quotes}missing{close_quotes} sink for carbon is hiding in the biosphere. Scenario dependent trace gas indices were calculated for CH{sub 4}, N{sub 2}O, HCFC-22.

  5. Lectures on relativistic quantum mechanics and path integration

    Gunn, J.M.F.

    1989-02-01

    The question posed is why bother with relativistic quantum mechanics? Three reasons are given: First that there are many experimental phenomena which cannot be explained in non-relativistic terms. Secondly it would be unsatisfactory if relativity and quantum mechanics could not be united. Thirdly, there are theoretical reasons why new effects can be expected at relativistic velocities. The objectives of the course are to set up relativistic analogues of the Schroedinger equation and to understand their consequences. In doing so there are some questions which are raised and discussed such as can a first order equation be used to describe spin 0 particles and a second order equation be used to describe spin 1/ 2 (author)

  6. Cleaner generation, free-riders, and environmental integrity: clean development mechanism and the power sector

    Bernow, Stephen; Kartha, Sivan; Lazarus, Michael; Page, Tom [Tellus Institute and Stockholm Environmental Institute-Boston Center, Boston, MA (United States)

    2001-06-01

    This article provides a first-cut estimate of the potential impacts of the clean development mechanism (CDM) on electricity generation and carbon emissions in the power sector of non-Annex 1 countries. We construct four illustrative CDM regimes that represent a range of approaches under consideration within the climate community. We examine the impact of these CDM regimes on investments in new generation, under illustrative carbon trading prices of US$ 10 and 100/tC. In the cases that are most conductive to CDM activity, roughly 94% of new generation investments remains identical to the without-CDM situation, with only 6% shifting from higher to lower carbon intensity technologies. We estimate that the CDM would bolster renewable energy generation by as little as 15% at US$ 10/tC, or as much as 300% at US$ 100/tC. A striking finding comes from our examination of the potential magnitude of the 'free-rider' problem, i.e. crediting of activities that will occur even in the absence of the CDM. The CDM is intended to be globally carbon-neutral --- a project reduces emissions in the host country but generates credits that increase emissions in the investor country. However, to the extent that unwarranted credits are awarded to non-additional projects, the CDM would increase global carbon emissions above the without-CDM emissions level. Under two of the CDM regimes considered, cumulative free-riders credits total 250-600MtC through the end of the first budget period in 2012. This represents 10-23% of the likely OECD emissions reduction requirement during the first budget period. Since such a magnitude of free-rider credits from non-additional CDM projects could threaten the environmental integrity of the Kyoto protocol, it is imperative that policy makers devise CDM rules that encourage legitimate projects, while effectively screening out non-additional activities. (Author)

  7. Integrated modelling of anthropogenic land-use and land-cover change on the global scale

    Schaldach, R.; Koch, J.; Alcamo, J.

    2009-04-01

    In many cases land-use activities go hand in hand with substantial modifications of the physical and biological cover of the Earth's surface, resulting in direct effects on energy and matter fluxes between terrestrial ecosystems and the atmosphere. For instance, the conversion of forest to cropland is changing climate relevant surface parameters (e.g. albedo) as well as evapotranspiration processes and carbon flows. In turn, human land-use decisions are also influenced by environmental processes. Changing temperature and precipitation patterns for example are important determinants for location and intensity of agriculture. Due to these close linkages, processes of land-use and related land-cover change should be considered as important components in the construction of Earth System models. A major challenge in modelling land-use change on the global scale is the integration of socio-economic aspects and human decision making with environmental processes. One of the few global approaches that integrates functional components to represent both anthropogenic and environmental aspects of land-use change, is the LandSHIFT model. It simulates the spatial and temporal dynamics of the human land-use activities settlement, cultivation of food crops and grazing management, which compete for the available land resources. The rational of the model is to regionalize the demands for area intensive commodities (e.g. crop production) and services (e.g. space for housing) from the country-level to a global grid with the spatial resolution of 5 arc-minutes. The modelled land-use decisions within the agricultural sector are influenced by changing climate and the resulting effects on biomass productivity. Currently, this causal chain is modelled by integrating results from the process-based vegetation model LPJmL model for changing crop yields and net primary productivity of grazing land. Model output of LandSHIFT is a time series of grid maps with land-use/land-cover information

  8. Globalization

    Plum, Maja

    Globalization is often referred to as external to education - a state of affair facing the modern curriculum with numerous challenges. In this paper it is examined as internal to curriculum; analysed as a problematization in a Foucaultian sense. That is, as a complex of attentions, worries, ways...... of reasoning, producing curricular variables. The analysis is made through an example of early childhood curriculum in Danish Pre-school, and the way the curricular variable of the pre-school child comes into being through globalization as a problematization, carried forth by the comparative practices of PISA...

  9. Globalization

    F. Gerard Adams

    2008-01-01

    The rapid globalization of the world economy is causing fundamental changes in patterns of trade and finance. Some economists have argued that globalization has arrived and that the world is “flat†. While the geographic scope of markets has increased, the author argues that new patterns of trade and finance are a result of the discrepancies between “old†countries and “new†. As the differences are gradually wiped out, particularly if knowledge and technology spread worldwide, the t...

  10. Leading global energy and environmental transformation: Unified ASEAN biomass-based bio-energy system incorporating the clean development mechanism

    Lim, Steven; Lee, Keat Teong

    2011-01-01

    In recent years, the ten member countries in the Association of Southeast Asia Nations (ASEAN) have experienced high economic growth and, in tandem, a substantial increment in energy usage and demand. Consequently, they are now under intense pressure to secure reliable energy supplies to keep up with their growth rate. Fossil fuels remain the primary source of energy for the ASEAN countries, due to economic and physical considerations. This situation has led to unrestrained emissions of greenhouse gases to the environment and thus effectively contributes to global climate change. The abundant supply of biomass from their tropical environmental conditions offers great potential for ASEAN countries to achieve self-reliance in energy supplies. This fact can simultaneously transform into the main driving force behind combating global climate change, which is associated with the usage of fossil fuels. This research article explores the potential and advantages for ASEAN investment in biomass-based bio-energy supply, processing and distribution network with an emphasis on regional collaborations. It also investigates the implementation and operational challenges in terms of political, economic and technical factors for the cross-border energy scheme. Reliance of ASEAN countries on the clean development mechanism (CDM) to address most of the impediments in developing the project is also under scrutiny. Unified co-operation among ASEAN countries in integrating biomass-based bio-energy systems and utilising the clean development mechanism (CDM) as the common effort could serve as the prime example for regional partnerships in achieving sustainable development for the energy and environmental sector in the future. -- Highlights: →A study that explores feasibility for ASEAN investment in biomass-based bio-energy. →Focus is given on regional supply, processing and distribution network. →Cross-border implementation and operational challenges are discussed thoroughly.

  11. Framework programmable platform for the advanced software development workstation. Integration mechanism design document

    Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Reddy, Uday; Ackley, Keith; Futrell, Mike

    1991-01-01

    The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software development environment. Guided by this model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated.

  12. The Effectiveness of Different Mechanisms for Integrating Marketing and R&D

    M.A.A.M. Leenders (Mark); B. Wierenga (Berend)

    2001-01-01

    textabstractThe integration of marketing and R&D is a major concern for companies that want to improve their new product performance (NPP). In order to integrate, companies are using mechanisms such as physical proximity, cross-functional teams, and job rotation. This study examines the relative

  13. Identification of mechanisms enabling integrated care for patients with chronic diseases: a literature review

    Denise van der Klauw

    2014-07-01

    Full Text Available Introduction: Notwithstanding care for chronically ill patients requires a shift towards care that is well coordinated and focused on prevention and self-care, the concept of integrated care lacks specificity and clarity. This article presents a literature review to identify mechanisms for achieving integrated care objectives.Theory and methods: Existing models often present a large variety of dimensions, archetypes and categories of integration without specifying them. Models and programmes describing integrated care for chronic diseases were reviewed. Data were extracted related to objectives and clusters of mechanisms of integration.Results: Thirty-four studies presented four objectives: functional, organisational, professional and service integration. We categorised approaches and interventions to achieve these objectives by strategy and clusters of ‘mechanisms of integration’: degree, patient centredness and normative aspects.Conclusions and discussion: The clarification of mechanisms to achieve objectives of integrated care as presented may be used as starting point for the development and refinement of integrated care programmes, including methodological grounding of their evaluation. Given that most studies reviewed lack both empirical data and descriptions of the methods used, future research needs to close these gaps. Validation of the findings by a large panel of experts is suggested as recommendation to work towards a grounded framework.

  14. A variational integrators approach to second order modeling and identification of linear mechanical systems

    Bruschetta, M.; Saccon, A.; Picci, G.

    2014-01-01

    The theory of variational integration provides a systematic procedure to discretize the equations of motion of a mechanical system, preserving key properties of the continuous time flow. The discrete-time model obtained by variational integration theory inherits structural conditions which in

  15. The mechanical integrity and protective performance of silica coatings

    Crouch, A.G.; Dooley, R.B.

    1976-01-01

    Silica coatings have been developed to reduce the oxidation rates of 9Cr and other steels in high temperature environments. An important aspect of their performance is their ability to withstand the mechanical and thermal strains likely to be encountered in practical applications. This has been examined. Silica-coated 9 Cr steel specimens were deformed in tension and coating failure was detected by scanning electron microscope observations of the oxide stringers which delineated the strain-induced cracks on subsequent exidation. Coating fracture was shown to occur in the strain range 0.27 to 0.45%. The crack separation at constant coating thickness decresed with strain and at constant strain was approximately proportional to the square root of the coating thickness. The implications of these results for the protection of the underlying alloy by a cracked coating are considered. (author)

  16. Eight plane IPND [Integration Prototype Near Detector] mechanical testing

    Zhao, A.; Guarino, V.; Wood, K.; Nephew, T.; Ayres, D.

    2008-01-01

    A mechanical test of an 8 plane IPND mechanical prototype, which was constructed using extrusions from the testing/tryout of the 16 cell prototype extrusion die in Argonne National Laboratory, was conducted. There were 4 vertical and 4 horizontal planes in this 8 plane IPND prototype. Each vertical plane had four 16 cell extrusions, while each horizontal plane had six 16 cell extrusions. Each plane was glued together using the formulation of Devcon adhesive, Devcon 60. The vertical extrusions used in the vertical planes shares the same dimensions as the horizontal extrusions in the horizontal planes with the average web thickness of 2.1 mm and the average wall thickness of 3.1 mm. This mechanical prototype was constructed with end-seals on the both ends of the vertical extrusions. The gaps were filled with epoxy between extrusions and end-seals. The overall dimension of IPND is 154.8 by 103.1 by 21.7 inches with the weight of approximately 1200 kg, as shown in a figure. Two similar mechanical tests of 3 layer and 11 layer prototypes have been done in order to evaluate the strength of the adhesive joint between extrusions in the NOvA detector. The test showed that the IPND prototype was able to sustain under the loading of weight of itself and scintillator. Two FEA models were built to verify the measurement data from the test. The prediction from FEA slice model seems correlated reasonably well to the test result, even under a 'rough' estimated condition for the wall thickness (from an untuned die) and an unknown property of 'garage type' extrusion. A full size of FEA 3-D model also agrees very well with the test data from strain gage readings. It is worthy to point out that the stress distribution of the structure is predominantly determined by the internal pressure, while the buckling stability relies more on the loading weight from the extrusions themselves and scintillate. Results of conducted internal pressure tests, including 3- cell, 11-cell and the IPND

  17. The educated citizen and global public health issues: One model for integration into the undergraduate curriculum

    Rosemary M. Caron

    2016-03-01

    Full Text Available The Educated Citizen Initiative proposes that an understanding of public health issues is a core component of an educated citizenry and is essential to developing one’s societal responsibility. This initiative supports the Institute of Medicine’s recommendation that all undergraduates should have access to education in public health. Furthermore, the Liberal Education and America’s Promise (LEAP framework developed by the Association of American Colleges and Universities supports the integration of public health education into general and liberal education with an aim to produce an educated citizenry. The LEAP framework is implemented by teaching about the role of social determinants in a population’s health status; the significance of personal and social responsibility; and providing skills for inquiry, critical thinking, problem solving, and evaluation. This article describes one university’s experience in generating an educated citizenry cognizant of comprehensive public health conflicts, thus contributing to both a local and global perspective on learning.

  18. Product architecture development enabling integrated re-design of mechanical products

    Begelinger, R.E.; Post, E.; van Houten, F.J.A.M.; Kals, H.J.J.

    1999-01-01

    Global competition forces companies to increase their competitive advantage. The design process represents an interesting area to improve the overall business performance. There are two topics involved in improving the design process. The first one is the integration of constraints from the product

  19. New Faces of Globalization: Market Integration, Production Disintegration, Genesis of New Global Organizational Structures for Production and Trade

    Sarmiza Pencea

    2010-01-01

    Due to trade liberalisation and ITC revolution, companies could imagine new and better ways of creating and delivering value. In search of higher efficiency, competitiveness and profits, they reorganise, choosing to focus on their core competencies and to globally outsource, or offshore non-core activities and functions. As a result, reorganisation and relocation became the new forces of change across economies, leading to the rise of new, more diverse and more efficient global organisational...

  20. The global resource balance table, an integrated table of energy, materials and the environment

    Tsuchiya, Haruki

    2013-01-01

    This paper introduces the Global Resource Balance Table (GRBT), which is an extension of the energy balance tables that expresses the relationships between energy, materials and the environment. The material division of the GRBT includes steel, cement, paper, wood and grain. In contrast, the environmental division of the GRBT includes oxygen, CO 2 and methane. The transaction division rows in the GRBT include production, conversion, end use and stock. Each cell of the GRBT contains the quantities of the respective resources that were generated or consumed. The relationships between the cells were constructed from the laws of conservation of the materials and energy. We constructed a GRBT for 2007 and discussed the increasing air temperature due to waste heat and the CO 2 equivalent from human breathing. The GRBT is a comprehensive integrated table that represents the resources that are consumed by human activities and is useful for energy and environmental studies. - Highlights: • We extended energy balance table and introduced Global Resource Balance Table. • It shows relationships between energy, materials and the environment. • The material division includes steel, cement, paper, wood and grain. • The environmental division includes oxygen, CO 2 and methane. • We discussed on waste heat and CO 2 emission by human breathing

  1. Overview of IMAGE 2.0. An integrated model of climate change and the global environment

    Alcamo, J.; Battjes, C.; Van den Born, G.J.; Bouwman, A.F.; De Haan, B.J.; Klein Goldewijk, K.; Klepper, O.; Kreileman, G.J.J.; Krol, M.; Leemans, R.; Van Minnen, J.G.; Olivier, J.G.J.; De Vries, H.J.M.; Toet, A.M.C.; Van den Wijngaart, R.A.; Van der Woerd, H.J.; Zuidema, G.

    1995-01-01

    The IMAGE 2.0 model is a multi-disciplinary, integrated model, designed to simulate the dynamics of the global society-biosphere-climate system. In this paper the focus is on the scientific aspects of the model, while another paper in this volume emphasizes its political aspects. The objectives of IMAGE 2.0 are to investigate linkages and feedbacks in the global system, and to evaluate consequences of climate policies. Dynamic calculations are performed to the year 2100, with a spatial scale ranging from grid (0.5x0.5 latitude-longitude) to world political regions, depending on the sub-model. A total of 13 sub-models make up IMAGE 2.0, and they are organized into three fully linked sub-systems: Energy-Industry, Terrestrial Environment, and Atmosphere-Ocean. The fully linked model has been tested against data from 1970 to 1990, and after calibration it can reproduce the following observed trends: regional energy consumption and energy-related emissions, terrestrial flux of carbon dioxide and emissions of greenhouse gases, concentrations of greenhouse gases in the atmosphere, and transformation of land cover. The model can also simulate current zonal average surface and vertical temperatures. 1 fig., 10 refs

  2. Integrated and global pseudotargeted metabolomics strategy applied to screening for quality control markers of Citrus TCMs.

    Shu, Yisong; Liu, Zhenli; Zhao, Siyu; Song, Zhiqian; He, Dan; Wang, Menglei; Zeng, Honglian; Lu, Cheng; Lu, Aiping; Liu, Yuanyan

    2017-08-01

    Traditional Chinese medicine (TCM) exerts its therapeutic effect in a holistic fashion with the synergistic function of multiple characteristic constituents. The holism philosophy of TCM is coincident with global and systematic theories of metabolomics. The proposed pseudotargeted metabolomics methodologies were employed for the establishment of reliable quality control markers for use in the screening strategy of TCMs. Pseudotargeted metabolomics integrates the advantages of both targeted and untargeted methods. In the present study, targeted metabolomics equipped with the gold standard RRLC-QqQ-MS method was employed for in vivo quantitative plasma pharmacochemistry study of characteristic prototypic constituents. Meanwhile, untargeted metabolomics using UHPLC-QE Orbitrap HRMS with better specificity and selectivity was employed for identification of untargeted metabolites in the complex plasma matrix. In all, 32 prototypic metabolites were quantitatively determined, and 66 biotransformed metabolites were convincingly identified after being orally administered with standard extracts of four labeled Citrus TCMs. The global absorption and metabolism process of complex TCMs was depicted in a systematic manner.

  3. Robust Myocardial Motion Tracking for Echocardiography: Variational Framework Integrating Local-to-Global Deformation

    Chi Young Ahn

    2013-01-01

    Full Text Available This paper proposes a robust real-time myocardial border tracking algorithm for echocardiography. Commonly, after an initial contour of LV border is traced at one or two frames from the entire cardiac cycle, LV contour tracking is performed over the remaining frames. Among a variety of tracking techniques, optical flow method is the most widely used for motion estimation of moving objects. However, when echocardiography data is heavily corrupted in some local regions, the errors bring the tracking point out of the endocardial border, resulting in distorted LV contours. This shape distortion often occurs in practice since the data acquisition is affected by ultrasound artifacts, dropouts, or shadowing phenomena of cardiac walls. The proposed method is designed to deal with this shape distortion problem by integrating local optical flow motion and global deformation into a variational framework. The proposed descent method controls the individual tracking points to follow the local motions of a specific speckle pattern, while their overall motions are confined to the global motion constraint being approximately an affine transform of the initial tracking points. Many real experiments show that the proposed method achieves better overall performance than conventional methods.

  4. JOURNAL CLUB: Redefining the Radiology Curriculum in Medical School: Vertical Integration and Global Accessibility.

    Retrouvey, Michele; Trace, Anthony Paul; Goodmurphy, Craig W; Shaves, Sarah

    2018-01-01

    Radiology interconnects medical disciplines given that a working understanding of imaging is essential to clinicians of every specialty. Using online education, we created a globally accessible, web-based undergraduate medical radiology curriculum modeled after the National Medical Student Curriculum in Radiology program of the Alliance of Medical Student Educators in Radiology. Seventy-four radiology faculty-mentored video modules were produced, 50 of which were integrated into the 1st-year anatomy course. We administered tests to medical students before and after students saw the videos to assess the effectiveness of the modules. We surveyed students on their interests in pursuing radiology as a career before and after participating in this curriculum. On the preexamination questions, the mean score was 58.0%, which increased to 83.6% on the pair-matched imaging-related questions on the actual examination. Before participating in the new curriculum, 88% of students did not express an interest in radiology, and 9% were undecided about radiology as a future career. There was an increase in students who reported that they would definitely or most likely pursue a career in radiology (7%) after they had viewed the lectures. Radiology education is now available to a greater number of multidisciplinary learners worldwide. This project produced a comprehensive, globally accessible radiology curriculum in a self-paced, flexible learning format for new generations of physicians.

  5. The NIAID Division of AIDS enterprise information system: integrated decision support for global clinical research programs

    Gupta, Nitin; Varghese, Suresh; Virkar, Hemant

    2011-01-01

    The National Institute of Allergy and Infectious Diseases (NIAID) Division of AIDS (DAIDS) Enterprise Information System (DAIDS-ES) is a web-based system that supports NIAID in the scientific, strategic, and tactical management of its global clinical research programs for HIV/AIDS vaccines, prevention, and therapeutics. Different from most commercial clinical trials information systems, which are typically protocol-driven, the DAIDS-ES was built to exchange information with those types of systems and integrate it in ways that help scientific program directors lead the research effort and keep pace with the complex and ever-changing global HIV/AIDS pandemic. Whereas commercially available clinical trials support systems are not usually disease-focused, DAIDS-ES was specifically designed to capture and incorporate unique scientific, demographic, and logistical aspects of HIV/AIDS treatment, prevention, and vaccine research in order to provide a rich source of information to guide informed decision-making. Sharing data across its internal components and with external systems, using defined vocabularies, open standards and flexible interfaces, the DAIDS-ES enables NIAID, its global collaborators and stakeholders, access to timely, quality information about NIAID-supported clinical trials which is utilized to: (1) analyze the research portfolio, assess capacity, identify opportunities, and avoid redundancies; (2) help support study safety, quality, ethics, and regulatory compliance; (3) conduct evidence-based policy analysis and business process re-engineering for improved efficiency. This report summarizes how the DAIDS-ES was conceptualized, how it differs from typical clinical trial support systems, the rationale for key design choices, and examples of how it is being used to advance the efficiency and effectiveness of NIAID's HIV/AIDS clinical research programs. PMID:21816958

  6. Standard Test Methods for Determining Mechanical Integrity of Photovoltaic Modules

    American Society for Testing and Materials. Philadelphia

    2009-01-01

    1.1 These test methods cover procedures for determining the ability of photovoltaic modules to withstand the mechanical loads, stresses and deflections used to simulate, on an accelerated basis, high wind conditions, heavy snow and ice accumulation, and non-planar installation effects. 1.1.1 A static load test to 2400 Pa is used to simulate wind loads on both module surfaces 1.1.2 A static load test to 5400 Pa is used to simulate heavy snow and ice accumulation on the module front surface. 1.1.3 A twist test is used to simulate the non-planar mounting of a photovoltaic module by subjecting it to a twist angle of 1.2°. 1.1.4 A cyclic load test of 10 000 cycles duration and peak loading to 1440 Pa is used to simulate dynamic wind or other flexural loading. Such loading might occur during shipment or after installation at a particular location. 1.2 These test methods define photovoltaic test specimens and mounting methods, and specify parameters that must be recorded and reported. 1.3 Any individual mech...

  7. Integrating Technical Communication in the Mechanical Engineering Curriculum

    Norberg, Seth; Ashcraft, Timothy; van Poppel, Bret

    2017-11-01

    Technical communication is essential to engineering practice, but these skills can be challenging to teach and assess in the classroom. Instructors in the Mechanical Engineering (ME) program at the United States Military Academy are developing new learning exercises to prepare students for success in their capstone design course and beyond. In this paper we highlight the recent successes and lessons learned from two courses: junior-level Thermal-Fluid Systems and the senior-level ME Seminar. Both courses support the newly implemented West Point Writing Program (WPWP), an institutional, writing-across-the-curriculum program. The junior course incorporates four hands-on experiments, which provide an abundance of data for students to analyze, assess, and present. In the senior course the majority of the content that students present is from their ongoing capstone design projects. Between the two courses, students craft essays, lab reports, short summaries, posters, quad charts, and technical presentations. Both courses include peer evaluation, revision exercises, and timed (on demand) writing assignments. The junior course includes assignments co-authored by a group as well as an individual report. An overview of both courses' assignments with course-end feedback from the students and the faculty is provided. Strengths and weaknesses are identified and recommendations for instructors seeking to implement similar technical communications assignments in their own courses are presented.

  8. Global thermo-mechanical effects from a KBS-3 type repository

    Hakami, E.; Olofsson, Stig-Olof

    1998-01-01

    The objective of this study has been to identify the global thermo-mechanical effects in the bedrock hosting a nuclear waste repository. Numerical thermo-mechanical modeling using distinct element models was performed. The number of fracture zones, the heat intensity of the waste, the material properties of the rock mass and the boundary conditions of the models were varied. Different models for multi-level repositories were also analyzed and compared to the main single-level case. Further, the global influence from the excavation of repository tunnels and deposition holes was examined by introducing weaker rock mass material properties in the repository region of one model. The maximum compression stress obtained for the main model is 44 MPa and occurs at the repository level after about 100 years of deposition. Due to thermal expansion, the rock mass displaces upward, and the maximum heave at the ground surface after 1000 years is calculated to be 16 cm. In the area close to the ground surface the horizontal stresses reduce, causing the rock to yield in tension down to a depth of about 80 meters. The fracture zones show opening displacements at shallow depths and closing and shearing at the repository level. The maximum displacements are 0.3-2.5 cm for closing, 0.0-0.8 cm for opening and 0.2-2.2 cm for shearing. The resultant stresses and displacements depend in large part on the assumptions made concerning the heat intensity of the waste. In the main model, an initial heat intensity of 10 W/m 2 is assumed, which gives larger effects than the case with 6 W/m 2 . Another important input parameter for the analysis is the Young's modulus of the rock mass. In the main model, a value of 30 GPa is assumed. Higher values of Young's modulus give larger thermo-mechanical effects. All multi-level repository layouts give rise to higher temperatures than the single-level layout, causing the compressive stresses to increase more at the repository level. The multi

  9. Pipeline integrity management: integration of geotechnical and mechanical assessment to control potential risks due to external forces

    Malpartida Moya, John E.; Sota, Giancarlo Massucco de la; Seri, Walter [Compania Operadora de Gas del Amazonas, Lima (Peru)

    2009-07-01

    Every pipeline integrity management system evaluates and controls various threats. On pipelines which have particular characteristics as it is the case of the Andean pipelines and pipelines crossing jungles, one of the main threats are the external forces. Even, this threat causes a greater number of failures than other threats like corrosion or the third part damage. Facing this situation, the pipeline integrity management system of TgP has achieved an important development in the use and suitable handling of the information provided by diverse techniques of pipeline mechanical inspection and geotechnical inspection of the right-of-way (ROW). This document presents our methodology, which interrelate information of the in-line inspection, information of geotechnical inspections of the ROW, instrumentation (Strain Gages), topographic monitoring, among others. All this information is supported in a Geographic Information System (GIS) which allows us to integrate the information. By means of the pipeline integrity management system we control potential risks due to external forces, we have been able to act before events become critical, with no occurrence of failures. This system allows us simultaneously to optimize efforts and preserve the mechanical integrity of our pipelines, not producing neither personal nor environmental nor economical affectation. (author)

  10. Point Climat no. 11 'Japan's Bilateral Offset Crediting Mechanism: A Bilateral Solution to a Global Issue?'

    Le, Hanh; Delbosc, Anais

    2012-01-01

    Among the publications of CDC Climat Research, 'Climate Briefs' presents, in a few pages, hot topics in climate change policy. This issue addresses the following points: In order to achieve its long-term emission reduction target following the Fukushima incident, Japan would rely more heavily on international offsetting activities. Concurrent to vigorous proposals to reform the CDM, Japan is also promoting an offset crediting scheme through bilateral agreements with developing countries as a post-2012 market mechanism. Despite potential benefits, issues relating to the accounting rules, environmental integrity and implications to carbon markets warrant further consideration prior to international recognition

  11. Simulated effect on the compressive and shear mechanical properties of bionic integrated honeycomb plates.

    He, Chenglin; Chen, Jinxiang; Wu, Zhishen; Xie, Juan; Zu, Qiao; Lu, Yun

    2015-05-01

    Honeycomb plates can be applied in many fields, including furniture manufacturing, mechanical engineering, civil engineering, transportation and aerospace. In the present study, we discuss the simulated effect on the mechanical properties of bionic integrated honeycomb plates by investigating the compressive and shear failure modes and the mechanical properties of trabeculae reinforced by long or short fibers. The results indicate that the simulated effect represents approximately 80% and 70% of the compressive and shear strengths, respectively. Compared with existing bionic samples, the mass-specific strength was significantly improved. Therefore, this integrated honeycomb technology remains the most effective method for the trial manufacturing of bionic integrated honeycomb plates. The simulated effect of the compressive rigidity is approximately 85%. The short-fiber trabeculae have an advantage over the long-fiber trabeculae in terms of shear rigidity, which provides new evidence for the application of integrated bionic honeycomb plates. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. The WTO Agreement on government procurement as a tool for Ukraine’s integration into the global value chains

    GUZHVA IGOR

    2015-01-01

    The article deals with the features of modern internationalization of production and economic relations among economic entities around the world based on the global value chains formation. The essence and the basic provisions of the multilateral WTO Agreement on Government Procurement as the integration tool of Ukraine’s industries into the global value chains are revealed. The Ukraine’s government procurement reforming progress towards the relevant WTO rules and regulations full implementati...

  13. Integrating abundance and functional traits reveals new global hotspots of fish diversity.

    Stuart-Smith, Rick D; Bates, Amanda E; Lefcheck, Jonathan S; Duffy, J Emmett; Baker, Susan C; Thomson, Russell J; Stuart-Smith, Jemina F; Hill, Nicole A; Kininmonth, Stuart J; Airoldi, Laura; Becerro, Mikel A; Campbell, Stuart J; Dawson, Terence P; Navarrete, Sergio A; Soler, German A; Strain, Elisabeth M A; Willis, Trevor J; Edgar, Graham J

    2013-09-26

    Species richness has dominated our view of global biodiversity patterns for centuries. The dominance of this paradigm is reflected in the focus by ecologists and conservation managers on richness and associated occurrence-based measures for understanding drivers of broad-scale diversity patterns and as a biological basis for management. However, this is changing rapidly, as it is now recognized that not only the number of species but the species present, their phenotypes and the number of individuals of each species are critical in determining the nature and strength of the relationships between species diversity and a range of ecological functions (such as biomass production and nutrient cycling). Integrating these measures should provide a more relevant representation of global biodiversity patterns in terms of ecological functions than that provided by simple species counts. Here we provide comparisons of a traditional global biodiversity distribution measure based on richness with metrics that incorporate species abundances and functional traits. We use data from standardized quantitative surveys of 2,473 marine reef fish species at 1,844 sites, spanning 133 degrees of latitude from all ocean basins, to identify new diversity hotspots in some temperate regions and the tropical eastern Pacific Ocean. These relate to high diversity of functional traits amongst individuals in the community (calculated using Rao's Q), and differ from previously reported patterns in functional diversity and richness for terrestrial animals, which emphasize species-rich tropical regions only. There is a global trend for greater evenness in the number of individuals of each species, across the reef fish species observed at sites ('community evenness'), at higher latitudes. This contributes to the distribution of functional diversity hotspots and contrasts with well-known latitudinal gradients in richness. Our findings suggest that the contribution of species diversity to a range of

  14. The New Coordinates of Globalization and Regional Integration: Resizing the Euro-Mediterranean Partnership

    Marcel Moldoveanu

    2017-04-01

    Full Text Available The increasingly strong process of interdependence between globalization and regionalization - in the context of the end of the bipolar power at world level - has engendered a new philosophy regarding the evolution of the world, a reconsideration of the strategy of political and diplomatic, economic and also cultural and human relationships. In my opinion, in a multipolar world, that will bring into the first line of international relations new big actors of regional and universal vocation (China, Rusia, Brasil, India, the European Union will play an extensive role in participating at the geostrategic, regional and global equilibrium, through promotion of an „open diplomacy” that will allow – by dialogue and cooperation – the resolving more rapidly and efficiently the great challenges of the beginning of the century and millenium: the reduction of the great development gaps, the regional and global security, in a very solid economic background. A new dimension of the EU enlargement policy at regional scale is represented by the cooperation relations and the attraction into the European circuit of material and spiritual values of the countries in the Central and Eastern Europe. In the context of deepening the interdependence and complementarities at regional and global level, more focus should be put on the viable ways and modalities to intensify the cooperation in the Danube-Black Sea and Euro-Mediterranean geo-economic and strategic areas. The two big geo-strategic regions of the world belong to the same civilization and are subject to similar changes as the other regions of the world, despite some specific features of history and culture. The intensification and diversification of the cooperation at the Central and South-Eastern European level, as well as the Euro-Mediterranean and Danube-Black Sea region, does not represent an alternative to the general objective process of integration into the Euro-Atlantic structures, but a

  15. Integrating optical, mechanical, and test software (with applications to freeform optics)

    Genberg, Victor; Michels, Gregory; Myer, Brian

    2017-10-01

    Optical systems must perform under environmental conditions including thermal and mechanical loading. To predict the performance in the field, integrated analysis combining optical and mechanical software is required. Freeform and conformal optics offer many new opportunities for optical design. The unconventional geometries can lead to unconventional, and therefore unintuitive, mechanical behavior. Finite element (FE) analysis offers the ability to predict the deformations of freeform optics under various environments and load conditions. To understand the impact on optical performance, the deformations must be brought into optical analysis codes. This paper discusses several issues related to the integrated optomechanical analysis of freeform optics.

  16. Global electricity transformation: The critical need for integrated market design and risk management research

    Hung-po Chao

    2006-01-01

    The past three decades transformed the electricity industry. The essential goals of liberalization have been to lower costs, improve reliability, and stimulate investment and innovations through establishment of competitive electricity markets, while also relying on market mechanisms to provide creative solutions to environmental and security problems. In many instances, these goals have been achieved, but the occurrence of some spectacular market failures have brought into question the whole restructuring effort. This paper reviews recent experiences with market reform and concludes that a significant cause of failure has been the rush to unbundle vertically integrated utilities without sufficient consideration of alternative ways to manage the risk of electricity market restructuring. In particular, there is a critical need for integrated market design and risk management research to improve the process of market transformation by taking a more evolutionary approach to discover a 'Third Way' above vertical integration and full unbundling. Such research can offer a crucial feedback link to the restructuring process by identifying important lessons to be learned from past experience and developing new analytical tools to help introduce more successful market designs for the future. (author)

  17. Integrated investigation approach for determining mechanical properties of poly-silicon membranes

    Brueckner, J.; Dehe, A.; Auerswald, E.; Dudek, R.; Michel, B.; Rzepka, S.

    2014-01-01

    A methodology is presented for determining mechanical properties of free-standing thin films such as poly-silicon membranes. The integrated investigation approach comprises test structure development, mechanical testing, and numerical simulation. All membrane test structures developed and manufactured consist of the same material but have different stiffness due to variations in the geometric design. The mechanical tests apply microscopic loads utilizing a nanoindentation tool. Young's modulu...

  18. A Study on Partnering Mechanism in B to B EC Server for Global Supply Chain Management

    Kaihara, Toshiya

    B to B Electronic Commerce (EC) technology is now in progress and regarded as an information infrastructure for global business. As the number and diversity of EC participants grows at the agile environment, the complexity of purchasing from a vast and dynamic array of goods and services needs to be hidden from the end user. Putting the complexity into the EC system instead means providing flexible auction server for enabling commerce within different business units. Market mechanism could solve the product distribution problem in the auction server by allocating the scheduled resources according to market prices. In this paper, we propose a partnering mechanism for B to B EC with market-oriented programming that mediates amongst unspecified various companies in the trade, and demonstrate the applicability of the economic analysis to this framework after constructing a primitive EC server. The proposed mechanism facilitates sophisticated B to B EC, which conducts a Pareto optimal solution for all the participating business units in the coming agile era.

  19. Transport, mechanical and global migration data of multilayer copolyamide nanocomposite films with different layouts.

    Scarfato, P; Garofalo, E; Di Maio, L; Incarnato, L

    2017-06-01

    Transport, mechanical and global migration data concern multilayer food packaging films with different layouts, all incorporating a layered silicate/polyamide nanocomposite as oxygen barrier layer, and a low-density polyethylene (LDPE) as moisture resistant layer in direct contact with food. The data are related to "Tuning of co-extrusion processing conditions and film layout to optimize the performances of PA/PE multilayer nanocomposite films for food packaging" by Garofalo et al. (2017) [1]. Nanocomposite multilayer films, with different relative layer thicknesses and clay types, were produced using a laboratory scale co-extrusion blown-film equipment and were analyzed in terms of transport to oxygen and water vapor, mechanical properties and overall migration. The results have shown that all the multilayer hybrid films, based on the copolyamide layer filled with Cloisite 30B, displayed the most significant oxygen barrier improvements and the best mechanical properties compared to the unfilled films. No significant alteration of the overall migration values was observed, as expectable [2], [3], [4]. The performance improvement was more relevant in the case of the film with the thinner nanocomposite layer.

  20. The integration of object levels and their content: a theory of global/local processing and related hemispheric differences.

    Hübner, Ronald; Volberg, Gregor

    2005-06-01

    This article presents and tests the authors' integration hypothesis of global/local processing, which proposes that at early stages of processing, the identities of global and local units of a hierarchical stimulus are represented separately from information about their respective levels and that, therefore, identity and level information have to be integrated at later stages. It further states that the cerebral hemispheres differ in their capacities for these binding processes. Three experiments are reported in which the integration hypothesis was tested. Participants had to identify a letter at a prespecified level with the viewing duration restricted by a mask. False reporting of the letter at the nontarget level was predicted to occur more often when the integration of identity and level could fail. This was the case. Moreover, visual-field effects occurred, as expected. Finally, a multinomial model was constructed and fitted to the data. ((c) 2005 APA, all rights reserved).

  1. New Faces of Globalization: Market Integration, Production Disintegration, Genesis of New Global Organizational Structures for Production and Trade

    Sarmiza Pencea

    2010-07-01

    Full Text Available Due to trade liberalisation and ITC revolution, companies could imagine new and better ways of creating and delivering value. In search of higher efficiency, competitiveness and profits, they reorganise, choosing to focus on their core competencies and to globally outsource, or offshore non-core activities and functions. As a result, reorganisation and relocation became the new forces of change across economies, leading to the rise of new, more diverse and more efficient global organisational structures for investment, production and trade. A number of developing countries with adequate comparative advantages could better benefit from these processes, accelerating their own industralization and modernization, increasing their access to new technologies and managerial know-how and turning themselves into successful, high-rate growing, „ emerging” economies. The paper concludes that under such a global backdrop, taking part in global value chains (GVC and in international production networks (IPNs could be the best strategic option for both company strategies and governmental catch-up policies, provided that, or especially if companies enjoy high competences and tacit skills which make them capable of assuming complex tasks and of climbing further the technological ladder.

  2. Integrated Collaborative E-Learning for the Global Management Education in the 21st Century

    Son, Barbara W. K.

    2017-01-01

    Rapidly growing information and communications technology and a more interconnected global world offer benefits and challenges to global business organizations. While exploring benefits from global workforce and global production, they must successfully adapt to their local market conditions and manage their multicultural resources. How can we…

  3. Quantifying biological integrity by taxonomic completeness: its utility in regional and global assessments.

    Hawkins, Charles P

    2006-08-01

    Water resources managers and conservation biologists need reliable, quantitative, and directly comparable methods for assessing the biological integrity of the world's aquatic ecosystems. Large-scale assessments are constrained by the lack of consistency in the indicators used to assess biological integrity and our current inability to translate between indicators. In theory, assessments based on estimates of taxonomic completeness, i.e., the proportion of expected taxa that were observed (observed/expected, O/E) are directly comparable to one another and should therefore allow regionally and globally consistent summaries of the biological integrity of freshwater ecosystems. However, we know little about the true comparability of O/E assessments derived from different data sets or how well O/E assessments perform relative to other indicators in use. I compared the performance (precision, bias, and sensitivity to stressors) of O/E assessments based on five different data sets with the performance of the indicators previously applied to these data (three multimetric indices, a biotic index, and a hybrid method used by the state of Maine). Analyses were based on data collected from U.S. stream ecosystems in North Carolina, the Mid-Atlantic Highlands, Maine, and Ohio. O/E assessments resulted in very similar estimates of mean regional conditions compared with most other indicators once these indicators' values were standardized relative to reference-site means. However, other indicators tended to be biased estimators of O/E, a consequence of differences in their response to natural environmental gradients and sensitivity to stressors. These results imply that, in some cases, it may be possible to compare assessments derived from different indicators by standardizing their values (a statistical approach to data harmonization). In situations where it is difficult to standardize or otherwise harmonize two or more indicators, O/E values can easily be derived from existing

  4. An alternative mechanism for international health aid: evaluating a Global Social Protection Fund.

    Basu, Sanjay; Stuckler, David; McKee, Martin

    2014-01-01

    Several public health groups have called for the creation of a global fund for 'social protection'-a fund that produces the international equivalent of domestic tax collection and safety net systems to finance care for the ill and disabled and related health costs. All participating countries would pay into a global fund based on a metric of their ability to pay and withdraw from the common pool based on a metric of their need for funds. We assessed how alternative strategies and metrics by which to operate such a fund would affect its size and impact on health system financing. Using a mathematical model, we found that common targets for health funding in low-income countries require higher levels of aid expenditures than presently distributed. Some mechanisms exist that may incentivize reduction of domestic health inequalities, and direct most funds towards the poorest populations. Payments from high-income countries are also likely to decrease over time as middle-income countries' economies grow.

  5. Decarbonizing the Global Economy - An Integrated Assessment of Low Carbon Emission Scenarios proposed in Climate Policy

    Hokamp, Sascha; Khabbazan, Mohammad Mohammadi

    2017-04-01

    In 2015, the Conference of the Parties (COP 21) reaffirmed to targeting the global mean temperature rise below 2 °C in 2100 while finding no consent on decarbonizing the global economy, and instead, the final agreement called for enhanced scientific investigation of low carbon emission scenarios (UNFCC, 2015). In addition, the Climate Action Network International (CAN) proposes Special Reports to address decarbonization and low carbon development including 1.5 °C scenarios (IPCC, 2016). In response to these developments, we investigate whether the carbon emission cuts, in accordance with the recent climate policy proposals, may reach the climate target. To tackle this research question, we employ the coupled climate-energy-economy integrated assessment Model of INvestment and endogenous technological Development (MIND, cf. Edenhofer et al., 2005, Neubersch et al. 2014). Extending MIND's climate module to the two-box version used in the Dynamic Integrated model of Climate and the Economy (DICE, cf. Nordhaus and Sztorc, 2013, Nordhaus 2014), we perform a cost-effectiveness analysis with constraints on anthropogenic carbon emissions. We show that a climate policy scenario with early decarbonization complies with the 2° C climate target, even without Carbon Capturing and Storage (CCS) or negative emissions (see van Vuuren et al., 2013, for negative emissions). However, using emission inertia of 3.7 percent annually, reflecting the inflexibility on transforming the energy sector, we find a climate policy with moderately low emissions from 2100 onwards at a cost in terms of Balanced Growth Equivalents (BGE, cf. Anthoff and Tol, 2009) of 0.764 % that requires an early (2035 vs. 2120) peak of investments in renewable energy production compared to a business-as-usual scenario. Hence, decarbonizing the global economy and achieving the 2 °C target might still be possible before 2100, but the window of opportunity is beginning to close. References: Anthoff, D., and Tol, R

  6. GLOFRIM v1.0 - A globally applicable computational framework for integrated hydrological-hydrodynamic modelling

    Hoch, Jannis M.; Neal, Jeffrey C.; Baart, Fedor; van Beek, Rens; Winsemius, Hessel C.; Bates, Paul D.; Bierkens, Marc F. P.

    2017-10-01

    We here present GLOFRIM, a globally applicable computational framework for integrated hydrological-hydrodynamic modelling. GLOFRIM facilitates spatially explicit coupling of hydrodynamic and hydrologic models and caters for an ensemble of models to be coupled. It currently encompasses the global hydrological model PCR-GLOBWB as well as the hydrodynamic models Delft3D Flexible Mesh (DFM; solving the full shallow-water equations and allowing for spatially flexible meshing) and LISFLOOD-FP (LFP; solving the local inertia equations and running on regular grids). The main advantages of the framework are its open and free access, its global applicability, its versatility, and its extensibility with other hydrological or hydrodynamic models. Before applying GLOFRIM to an actual test case, we benchmarked both DFM and LFP for a synthetic test case. Results show that for sub-critical flow conditions, discharge response to the same input signal is near-identical for both models, which agrees with previous studies. We subsequently applied the framework to the Amazon River basin to not only test the framework thoroughly, but also to perform a first-ever benchmark of flexible and regular grids on a large-scale. Both DFM and LFP produce comparable results in terms of simulated discharge with LFP exhibiting slightly higher accuracy as expressed by a Kling-Gupta efficiency of 0.82 compared to 0.76 for DFM. However, benchmarking inundation extent between DFM and LFP over the entire study area, a critical success index of 0.46 was obtained, indicating that the models disagree as often as they agree. Differences between models in both simulated discharge and inundation extent are to a large extent attributable to the gridding techniques employed. In fact, the results show that both the numerical scheme of the inundation model and the gridding technique can contribute to deviations in simulated inundation extent as we control for model forcing and boundary conditions. This study shows

  7. The strategic decisions and success factors of the global integration-local responsiveness of Japanese MNCs in China

    MAO Yunshi; WANG Jiancheng

    2007-01-01

    This article applies Foreign Direct Investment (FDI) theories to the strategic management analysis of the global integration-local responsiveness of multinational corporations (MNCs) in China, from the perspective of company characteristics (ownership advantages and internalization advantages) and environmental dynamics (locational factors) in order to analyze the success factors influencing the sales activities of Japanese MNCs in China. Based on the analysis of a survey conducted on 230 Japanese parent companies with investments in China, the empirical research findings include: Japanese MNCs in China favor global integration strategies; the more significant the ownership advantages and internalization advantages are, the greater the global integration is; the success factors of their operations in China due to global integration are present in manufacturing know-how, procurement of parts and supplies, financial power, previous investment experience in China as well as sales networks and technologies; locational advantages mainly lie in labor cost among other things; internalization factors do not have any significant correlation with the success and performance of the subsidiary company.

  8. 76 FR 19174 - In the Matter of Circuit Systems, Inc., Global Energy Group, Inc., Integrated Medical Resources...

    2011-04-06

    ... SECURITIES AND EXCHANGE COMMISSION File No. 500-1 In the Matter of Circuit Systems, Inc., Global Energy Group, Inc., Integrated Medical Resources, Inc., iNTELEFILM Corp., and Lot$off Corp.; Order of... lack of current and accurate information concerning the securities of Circuit Systems, Inc. because it...

  9. Paved with good intentions: global financial integration, the eurozone, and the hellish road to the fabled gold standard

    Underhill, G.R.D.; Claes, D.H.; Knutsen, C.H.

    2011-01-01

    Regional systems of governance may resolve some of the dilemmas of global financial integration, and the eurozone is among the most advanced examples of attempts to do so. This paper argues that the recent Euroland sovereign debt crisis is a test of this proposition, and the outcome leaves the EU

  10. Paved with good intentions: global financial integration, the eurozone, and the imaginary road to the fabled gold standard

    Underhill, G.R.D.

    2010-01-01

    Regional systems of governance may resolve some of the dilemmas of global financial integration, and the eurozone is among the most advanced examples of attempts to do so. This paper argues that the recent Euroland sovereign debt crisis is a test of this proposition, and the outcome leaves the EU

  11. Global Economic Integration and Local Community Resilience: Road Paving and Rural Demographic Change in the Southwestern Amazon

    Perz, Stephen G.; Cabrera, Liliana; Carvalho, Lucas Araujo; Castillo, Jorge; Barnes, Grenville

    2010-01-01

    Recent years have witnessed an expansion in international investment in large-scale infrastructure projects with the goal of achieving global economic integration. We focus on one such project, the Inter-Oceanic Highway in the "MAP" region, a trinational frontier where Bolivia, Brazil, and Peru meet in the southwestern Amazon. We adopt a…

  12. Developing a common strategy for integrative global change research and outreach: the Earth System Science Partnership (ESSP)

    Leemans, R.; Asrar, G.; Canadell, J.G.; Ingram, J.; Larigauderie, A.; Mooney, H.; Nobre, C.; Patwardhan, A.; Rice, M.; Schmidt, F.; Seitzinger, S.; Virji, H.; Vörösmarthy, C.; Yuoung, O.

    2009-01-01

    The Earth System Science Partnership (ESSP) was established in 2001 by four global environmental change (GEC) research programmes: DIVERSITAS, IGBP, IHDP and WCRP. ESSP facilitates the study of the Earth's environment as an integrated system in order to understand how and why it is changing, and to

  13. Effect of the Shrink Fit and Mechanical Tolerance on Reactor Coolant Pump Flywheel Integrity Evaluation

    Kim, Donghak [Korea KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Reactor coolant pump (RCP) flywheel should satisfy the RCP flywheel integrity criteria of the US NRC standard review plan (SRP) 5.4.1.1 and regulatory guide (RG) 1.14. Shrink-fit and rotational stresses should be calculated to evaluate the integrity. In this paper the effects of the shrink fit and mechanical tolerance on the RCP flywheel integrity evaluation are studied. The shrink fit should be determined by the joint release speed and the stresses in the flywheel will be increased by the shrink fit. The stress at the interface between the hub and the outer wheel shows the highest value. The effect of the mechanical tolerance should be considered for the stress evaluation. And the effect of the mechanical tolerance should be not considered to determine the joint release speed.

  14. Effect of the Shrink Fit and Mechanical Tolerance on Reactor Coolant Pump Flywheel Integrity Evaluation

    Kim, Donghak

    2015-01-01

    Reactor coolant pump (RCP) flywheel should satisfy the RCP flywheel integrity criteria of the US NRC standard review plan (SRP) 5.4.1.1 and regulatory guide (RG) 1.14. Shrink-fit and rotational stresses should be calculated to evaluate the integrity. In this paper the effects of the shrink fit and mechanical tolerance on the RCP flywheel integrity evaluation are studied. The shrink fit should be determined by the joint release speed and the stresses in the flywheel will be increased by the shrink fit. The stress at the interface between the hub and the outer wheel shows the highest value. The effect of the mechanical tolerance should be considered for the stress evaluation. And the effect of the mechanical tolerance should be not considered to determine the joint release speed

  15. Towards an integrative post-2015 sustainable development goal framework: Focusing on global justice – peace, security and basic human rights

    George R. Lueddeke

    2015-12-01

    To strengthen the likelihood of realizing the post-2015 Sustainable Development Goals (SDGs, particularly with regard to “planet and population” health and well-being , UN and other decision-makers are urged to consider the adoption of an integrated SDG framework that is based on (i a vision of global justice - underpinned by peace, security and basic human rights; (ii the development of interdependent and interconnected strategies for each of the eleven thematic indicators identified in the UN document The World We Want; and (iii the application of guiding principles to measure the impact of SDG strategies in terms of holism, equity, sustainability, ownership, and global obligation. While current discussions on the SDGs are making progress in a number of areas, the need for integration of these around a common global vision and purpose seems especially crucial to avoid MDG shortcomings.

  16. Global Integration, Non-Oil Export and Economic Growth in Nigeria

    Ozoemena Stanley Nwodo

    2017-03-01

    Full Text Available This study focuses on global integration, non-oil export and economic growth in Nigeria. The direct and interaction effect of the both openness variables and non-oil export on economic growth in Nigeria is investigated using quarterly data from 1986-2014. For analysis, it uses one measures of financial openness: de facto (total capital flow variables following Aizenman and Noy (2009.and a measure of trade openness adopted by Okoh (2004. The study applies the Autoregressive Distributed Lag Model (ARDL. The results show positive impact of non-oil export on economic growth in Nigeria both in the short run and in the long run, negative effect of trade and financial openness on economic growth however, the result recorded a negative effect of the interaction of trade openness and non-oil export on economic growth and a positive effect of the interaction of financial openness and non-oil export on economic growth. Thus, the study recommends among others that government should get the fundamentals right in the economy first that will boost non-oil sector before opening the economy for trade.

  17. Management model of productive capacity: integrating theory of constraints and the global operational efficiency index (IROG

    Diego Augusto Pacheco

    2012-08-01

    Full Text Available This paper presents a model of management capacity in productive systems integrating the concepts of the Theory of Constraints and Total Productive Maintenance (TPM. The main objective of this study is to discuss and propose a model of management capacity, able to answer the following key questions: i capacity indicators which should be considered and how to measure them to measure the productive capacity of manufacturing systems? ii what is the real productive capacity of the system analyzed under a determined relationship between capacity and demand? The discussion of the proposed model is relevant because the definition of productive capacity system enables better management of resources and capabilities, improve production scheduling on the factory floor and meeting the demands imposed by the market. This paper presents the proposition of using the Operating Income Index Global (IROG with a different approach from traditional literature dealing with the theme, presented by Nakajima (1988. The results of this paper enable to develop a model to determine the capacity of the production system and the impact on the productive capacity of the entire system, not to consider the quality conformances that occur after the bottleneck resource of the production flow.

  18. Integrating women's human rights into global health research: an action framework.

    Baptiste, Donna; Kapungu, Chisina; Khare, Manorama H; Lewis, Yvonne; Barlow-Mosha, Linda

    2010-11-01

    This article uses Scale of Change theory as a framework to guide global health researchers to synergistically target women's health outcomes in the context of improving their right to freedom, equity, and equality of opportunities. We hypothesize that health researchers can do so through six action strategies. These strategies include (1) becoming fully informed of women's human rights directives to integrate them into research, (2) mainstreaming gender in the research, (3) using the expertise of grass roots women's organizations in the setting, (4) showcasing women's equity and equality in the organizational infrastructure, (5) disseminating research findings to policymakers in the study locale to influence health priorities, and (6) publicizing the social conditions that are linked to women's diseases. We explore conceptual and logistical dilemmas in transforming a study using these principles and also provide a case study of obstetric fistula reduction in Nigeria to illustrate how these strategies can be operationalized. Our intent is to offer a feasible approach to health researchers who, conceptually, may link women's health to social and cultural conditions but are looking for practical implementation strategies to examine a women's health issue through the lens of their human rights.

  19. Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review).

    Stefano, George B; Esch, Tobias

    2005-10-01

    Relaxation techniques are part of the integrative medicine movement that is of growing importance for mainstream medicine. Complementary medical therapies have the potential to affect many physiological systems. Repeatedly studies show the benefits of the placebo response and relaxation techniques in the treatment of hypertension, cardiac arrhythmias, chronic pain, insomnia, anxiety and mild and moderate depression, premenstrual syndrome, and infertility. In itself, relaxation is characterized by a decreased metabolism, heart rate, blood pressure, and rate of breathing as well as an increase in skin temperature. Relaxation approaches, such as progressive muscle relaxation, autogenic training, meditation and biofeedback, are effective in lowering systolic and diastolic blood pressure in hypertensive patients by a significant margin. Given this association with changes in vascular tone, we have hypothesized that nitric oxide, a demonstrated vasodilator substance, contribute to physiological activity of relaxation approaches. We examined the scientific literature concerning the disorders noted earlier for their nitric oxide involvement in an attempt to provide a molecular rationale for the positive effects of relaxation approaches, which are physiological and cognitive process. We conclude that constitutive nitric oxide may crucially contribute to potentially beneficial outcomes and effects in diverse pathologies, exerting a global healing effect.

  20. Microseismic event location using global optimization algorithms: An integrated and automated workflow

    Lagos, Soledad R.; Velis, Danilo R.

    2018-02-01

    We perform the location of microseismic events generated in hydraulic fracturing monitoring scenarios using two global optimization techniques: Very Fast Simulated Annealing (VFSA) and Particle Swarm Optimization (PSO), and compare them against the classical grid search (GS). To this end, we present an integrated and optimized workflow that concatenates into an automated bash script the different steps that lead to the microseismic events location from raw 3C data. First, we carry out the automatic detection, denoising and identification of the P- and S-waves. Secondly, we estimate their corresponding backazimuths using polarization information, and propose a simple energy-based criterion to automatically decide which is the most reliable estimate. Finally, after taking proper care of the size of the search space using the backazimuth information, we perform the location using the aforementioned algorithms for 2D and 3D usual scenarios of hydraulic fracturing processes. We assess the impact of restricting the search space and show the advantages of using either VFSA or PSO over GS to attain significant speed-ups.

  1. A simple integrated assessment approach to global change simulation and evaluation

    Ogutu, Keroboto; D'Andrea, Fabio; Ghil, Michael

    2016-04-01

    We formulate and study the Coupled Climate-Economy-Biosphere (CoCEB) model, which constitutes the basis of our idealized integrated assessment approach to simulating and evaluating global change. CoCEB is composed of a physical climate module, based on Earth's energy balance, and an economy module that uses endogenous economic growth with physical and human capital accumulation. A biosphere model is likewise under study and will be coupled to the existing two modules. We concentrate on the interactions between the two subsystems: the effect of climate on the economy, via damage functions, and the effect of the economy on climate, via a control of the greenhouse gas emissions. Simple functional forms of the relation between the two subsystems permit simple interpretations of the coupled effects. The CoCEB model is used to make hypotheses on the long-term effect of investment in emission abatement, and on the comparative efficacy of different approaches to abatement, in particular by investing in low carbon technology, in deforestation reduction or in carbon capture and storage (CCS). The CoCEB model is very flexible and transparent, and it allows one to easily formulate and compare different functional representations of climate change mitigation policies. Using different mitigation measures and their cost estimates, as found in the literature, one is able to compare these measures in a coherent way.

  2. Technologies for water resources management: an integrated approach to manage global and regional water resources

    Tao, W. C., LLNL

    1998-03-23

    regional water resources; As an evaluation tool for selecting appropriate remediation technologies for reclaiming water; and As an assessment tool for determining the effectiveness of implementing the remediation technologies. We have included a discussion on the appropriate strategy for LLNL to integrate its technical tools into the global business, geopolitical, and academic communities, whereby LLNL can form partnerships with technology proponents in the commercial, industrial, and public sectors.

  3. An integrative process model of leadership: examining loci, mechanisms, and event cycles.

    Eberly, Marion B; Johnson, Michael D; Hernandez, Morela; Avolio, Bruce J

    2013-09-01

    Utilizing the locus (source) and mechanism (transmission) of leadership framework (Hernandez, Eberly, Avolio, & Johnson, 2011), we propose and examine the application of an integrative process model of leadership to help determine the psychological interactive processes that constitute leadership. In particular, we identify the various dynamics involved in generating leadership processes by modeling how the loci and mechanisms interact through a series of leadership event cycles. We discuss the major implications of this model for advancing an integrative understanding of what constitutes leadership and its current and future impact on the field of psychological theory, research, and practice. © 2013 APA, all rights reserved.

  4. Path integrals in quantum mechanics, statistics, polymer physics, and financial markets

    Kleinert, Hagen

    2009-01-01

    This is the fifth, expanded edition of the comprehensive textbook published in 1990 on the theory and applications of path integrals. It is the first book to explicitly solve path integrals of a wide variety of nontrivial quantum-mechanical systems, in particular the hydrogen atom. The solutions have been made possible by two major advances. The first is a new euclidean path integral formula which increases the restricted range of applicability of Feynman's time-sliced formula to include singular attractive 1/r- and 1/r2-potentials. The second is a new nonholonomic mapping principle carrying p

  5. Evaluation of quantum mechanics path integrals by the approximations exact on a class of polynomial functionals

    Lobanov, Yu.Yu.; Shidkov, E.P.

    1987-01-01

    The method for numerical evaluation of path integrals in Eucledean quantum mechanics without lattice discretization is elaborated. The method is based on the representation of these integrals in the form of functional integrals with respect to the conditional Wiener measure and on the use of the derived approximate exact on a class of polynomial functionals of a given degree. By the computations of non-perturbative characteristics, concerned the topological structure of vacuum, the advantages of this method versus lattice Monte-Carlo calculations are demonstrated

  6. A System of Systems Approach to Integrating Global Sea Level Change Application Programs

    Bambachus, M. J.; Foster, R. S.; Powell, C.; Cole, M.

    2005-12-01

    The global sea level change application community has numerous disparate models used to make predications over various regional and temporal scales. These models have typically been focused on limited sets of data and optimized for specific areas or questions of interest. Increasingly, decision makers at the national, international, and local/regional levels require access to these application data models and want to be able to integrate large disparate data sets, with new ubiquitous sensor data, and use these data across models from multiple sources. These requirements will force the Global Sea Level Change application community to take a new system-of-systems approach to their programs. We present a new technical architecture approach to the global sea level change program that provides external access to the vast stores of global sea level change data, provides a collaboration forum for the discussion and visualization of data, and provides a simulation environment to evaluate decisions. This architectural approach will provide the tools to support multi-disciplinary decision making. A conceptual system of systems approach is needed to address questions around the multiple approaches to tracking and predicting Sea Level Change. A systems of systems approach would include (1) a forum of data providers, modelers, and users, (2) a service oriented architecture including interoperable web services with a backbone of Grid computing capability, and (3) discovery and access functionality to the information developed through this structure. Each of these three areas would be clearly designed to maximize communication, data use for decision making and flexibility and extensibility for evolution of technology and requirements. In contemplating a system-of-systems approach, it is important to highlight common understanding and coordination as foundational to success across the multiple systems. The workflow of science in different applications is often conceptually similar

  7. Managing two cultural identities: the malleability of bicultural identity integration as a function of induced global or local processing.

    Mok, Aurelia; Morris, Michael W

    2012-02-01

    Increasingly, individuals identify with two or more cultures. Prior research has found the degree to which individuals chronically integrate these identities (bicultural identity integration; BII) moderates responses to cultural cues: High BII individuals assimilate (adopting biases that are congruent with norms of the cued culture), whereas low BII individuals contrast (adopting biases that are incongruent with these norms). The authors propose BII can also be a psychological state and modulated by shifts in processing styles. In four experiments, the authors induced a global or local processing style using physical posture (Experiment 1) and cognitive manipulations (Experiments 2-4) and found that BII is enhanced in contexts facilitating a more global processing style (i.e., smiling, high-level construal, and similarity focus). The authors also found that contrastive responses to cultural cues are diminished when BII is situationally enhanced. Implications for research on processing style, identity integration, and performance in culture-based situations are discussed.

  8. First detection of global dawn-dusk ionospheric current intensities using Ampere's integral law on Orsted orbits

    Stauning, P.; Primdahl, Fritz

    2000-01-01

    -to-dusk ionospheric current is found to be proportional to the gee-effective solar wind electric field and is around 1 million ampere for a typical solar wind electric field of 2 mV/m. Dividing the Ampere integral into semi-orbit parts has enabled us to show that the hemispherical total current intensities depend......The magnetic measurements by the Orsted satellite in noon-midnight orbits have enabled the derivation of the global dawn-dusk oriented ionospheric currents from an Ampere's law closed loop line integral of the geomagnetic vector field along the satellite track. The globally integrated dawn...... on the respective polar cap conductivities, which relate to the daily and seasonally varying solar illumination. The more illuminated hemisphere conveys up to three times more current from dawn to dusk than does the less illuminated....

  9. The Impact of Globalization on a Country's Quality of Life: Toward an Integrated Model

    Sirgy, M. Joseph; Lee, Dong-Jin; Miller, Chad; Littlefield, James E.

    2004-01-01

    The purpose of the paper is to develop a set of theoretical propositions to explain the impact of globalization on a country's quality of life (QOL). In this paper, we describe how globalization impacts the quality of life of residents of a country by first articulating the globalization construct (in terms of inflows and outflows of goods,…

  10. Canceling effect: a natural mechanism to reduce the effects of global warming

    Razavi, Bahar S.; Blagodatskaya, Evgenia; kuzyakov, Yakov

    2016-04-01

    The temperature sensitivity of enzymes responsible for organic matter decomposition in soil is crucial for predicting the effects of global warming on the carbon cycle and sequestration. We tested the hypothesis that differences in temperature sensitivity of enzyme kinetic parameters Vmax and Km will lead to a canceling effect: strong reduction of temperature response of catalytic reactions. Short-term temperature response of Vmax and Km of three hydrolytic enzymes responsible for decomposition of cellulose (β-glucosidase, cellobiohydrolase) and hemicelluloses (xylanase) were analyzed in situ from 0 to 40 °C. The apparent activation energy varied between enzymes from 20.7 to 35.2 kJ mol-1 corresponding to the Q10 values of the enzyme activities of 1.4-1.9 (with Vmax-Q10 1.0-2.5 and Km-Q10 0.94-2.3). Temperature response of all tested enzymes fitted well to the Arrhenius equation. Despite that,the fitting of Arrhenius model revealed the non-linear increase of two cellulolytic enzymes activities with two distinct thresholds at 10-15 °C and 25-30 °C, which were less pronounced for xylanase. The nonlinearity between 10 and 15 °C was explained by 30-80% increase in Vmax. At 25-30 °C, however, the abrupt decrease of enzyme-substrate affinity was responsible for non-linear increase of enzyme activities. Our study is the first demonstrating nonlinear response of Vmax and Km to temperature causing canceling effect, which was most strongly pronounced at low substrate concentrations and at temperatures above 15 °C. Under cold climate, however, the regulation of hydrolytic activity by canceling in response to warming is negligible because canceling was never observed below 10 °C. The canceling, therefore, can be considered as natural mechanism reducing the effects of global warming on decomposition of soil organics at moderate temperatures. The non-linearity of enzyme responses to warming and the respective thresholds should therefore be investigated for other enzymes

  11. The MIT Integrated Global System Model: A facility for Assessing and Communicating Climate Change Uncertainty (Invited)

    Prinn, R. G.

    2013-12-01

    The world is facing major challenges that create tensions between human development and environmental sustenance. In facing these challenges, computer models are invaluable tools for addressing the need for probabilistic approaches to forecasting. To illustrate this, I use the MIT Integrated Global System Model framework (IGSM; http://globalchange.mit.edu ). The IGSM consists of a set of coupled sub-models of global economic and technological development and resultant emissions, and physical, dynamical and chemical processes in the atmosphere, land, ocean and ecosystems (natural and managed). Some of the sub-models have both complex and simplified versions available, with the choice of which version to use being guided by the questions being addressed. Some sub-models (e.g.urban air pollution) are reduced forms of complex ones created by probabilistic collocation with polynomial chaos bases. Given the significant uncertainties in the model components, it is highly desirable that forecasts be probabilistic. We achieve this by running 400-member ensembles (Latin hypercube sampling) with different choices for key uncertain variables and processes within the human and natural system model components (pdfs of inputs estimated by model-observation comparisons, literature surveys, or expert elicitation). The IGSM has recently been used for probabilistic forecasts of climate, each using 400-member ensembles: one ensemble assumes no explicit climate mitigation policy and others assume increasingly stringent policies involving stabilization of greenhouse gases at various levels. These forecasts indicate clearly that the greatest effect of these policies is to lower the probability of extreme changes. The value of such probability analyses for policy decision-making lies in their ability to compare relative (not just absolute) risks of various policies, which are less affected by the earth system model uncertainties. Given the uncertainties in forecasts, it is also clear that

  12. An integrated framework to address climate change (ESCAPE) and further developments of the global and regional climate modules (MAGICC)

    Hulme, M.; Raper, S.C.B.

    1995-01-01

    ESCAPE (the Evaluation of Strategies to address Climate change by Adapting to and Preventing Emissions) is an integrated climate change assessment model constructed between 1990 and 1992 for DG XI of the Commission of the European Community by a consortium of research institutes headed by the Climatic Research Unit (CRU). It has been designed to enable the user to generate future scenarios of greenhouse gas emissions (through an energy-economic model), examine their impact on global climate and sea level (through two independent global climate models), and illustrate some of the consequences of this global climate change at a regional scale for the European Community (through a regional climate scenario generator and impact models). We provide a very brief overview of the ESCAPE model which, although innovative, suffers from a number of major limitations. Subsequent work in the CRU has concentrated on improvements to the global climate module and work has also commenced on an improved regional climate scenario generating module. These improvements will lead to a new integrated climate change assessment model, MAGICC (Model for the Assessment of Greenhouse gas Induced Climate Change) which can easily be incorporated into new larger integrated frameworks developed by other institutes. (Author)

  13. On certain two-dimensional conservative mechanical systems with a cubic second integral

    Yehia, H M

    2002-01-01

    In a previous paper (Yehia H M 1986 J. Mec. Theor. Appl. 5 55-71) we have introduced a method for constructing integrable conservative two-dimensional mechanical systems whose second integral of motion is polynomial in the velocities. This method has proved successful in constructing a multitude of irreversible systems (involving gyroscopic forces) with a second quadratic integral (Yehia H M 1992 J. Phys. A: Math. Gen. 25 197-221). The objective of this paper is to apply the same method for the systematic construction of mechanical systems with a cubic integral. As in our previous works, the configuration space is not assumed to be a Euclidean plane. This widens the range of applicability of the results to diverse mechanical systems to include such problems as rigid body dynamics. Several new reversible and irreversible integrable systems are obtained. Some of these systems generalize previously known ones by introducing additional parameters which may change either or both of the configuration manifold and t...

  14. Teaching Basic Quantum Mechanics in Secondary School Using Concepts of Feynman Path Integrals Method

    Fanaro, Maria de los Angeles; Otero, Maria Rita; Arlego, Marcelo

    2012-01-01

    This paper discusses the teaching of basic quantum mechanics in high school. Rather than following the usual formalism, our approach is based on Feynman's path integral method. Our presentation makes use of simulation software and avoids sophisticated mathematical formalism. (Contains 3 figures.)

  15. An integrated finite-element approach to mechanics, transport and biosynthesis in tissue engineering

    Sengers, B.G.; Oomens, C.W.J.; Baaijens, F.P.T.

    2004-01-01

    A finite-element approach was formulated, aimed at enabling an integrated study of mechanical and biochemical factors that control the functional development of tissue engineered constructs. A nonlinear biphasic displacement-velocity-pressure description was combined with adjective and diffusive

  16. Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

    Hof, Van den W.F.P.M.; Ruiz Aracama, Ainhoa; Summeren, Van Anke; Jennen, D.G.J.; Gaj, Stan; Coonen, M.L.J.; Brauers, Karen; Wodzig, W.K.W.H.; Delft, van J.H.M.; Kleinjans, J.C.S.

    2015-01-01

    In order to improve attrition rates of candidate-drugs there is a need for a better understanding of the mechanisms underlying drug-induced hepatotoxicity. We aim to further unravel the toxicological response of hepatocytes to a prototypical cholestatic compound by integrating transcriptomic and

  17. Irradiation effects on the mechanical properties of aluminium and the structural integrity of aluminium reactor components

    Harrison, R.P.; McDonald, N.R.; Mitchell, D.R.G.; Hellier, A.K.; Stathers, P.A.; Carr, D.G.; Ripley, M.I.

    2000-01-01

    The results of micro-structural and mechanical property studies on aluminum after being exposed to large fluences of neutrons are presented. These property changes are of importance in determining the structural integrity of the Australian HIFAR reactor aluminium tank, which in turn determines the lifetime of the reactor. (author)

  18. Canada and the North American Free Trade Agreement: Between globalization and regional integration

    Caterina García Segura

    1995-07-01

    Full Text Available The aim of the present article is to analize, from Canada’s perspective, the choice regarding the model of state as well as of economic and commercial policy which the decision to participate in the North American Free Trade Agreement (NAFTA implies. The debatewhich NAFTA provoked in Canada expresses in concrete terms that debate which, in much larger terms, takes place at the international level regarding the multilateralization and/or the regionalization of commercial exchanges. It is a reflection of the tension between theintegrating forces (process of globalization and the fragmenting ones (processes of regionalization which characterize the dynamics of the contemporary international system. The hypothesis of this work is that in spite of being a commercial agreement, the Canadian government’s decision to participate in NAFTA was a decision of a political nature which was not determined exclusively by the reality of the existing commercial exchanges between Canada and Mexico or by the perspectives of improving them inthe short term. The immediate objective of Canada was to avoid that a possible bilateral agreement between its prinicipal economic member, the United States, and Mexico would empty out the contents of the existing Free Trade Agreement (FTA between Canada and the United States. In this sense, NAFTA was the possible remedy to an unwanted situation (the negotiation of a US-Mexico bilateral agreement. The objective in the medium and long term is use the platform of regional integration as a trampoline from where the Canadian economy can be reorientated and driven in order to attain international competitiveness. In this sense, Canada’s true option had already beenrealised with the FTA.

  19. Mechanical integration studies for the CLIC vertex and inner tracking detectors

    Villarejo Bermudez, M.A.; Gerwig, H.

    2015-01-01

    Since the publication of the CLIC Conceptual Design Report, work has proceeded in order to establish a preliminary mechanical design for the innermost CLIC detector region. This note proposes a design for the main Carbon-Fibre Reinforced Polymer (CFRP) structural elements of the inner detectors, for the beam pipe and their supports. It also describes an assembly sequence for the integration of the sensors and the mechanical components. Mechanical simulations of different structural elements and a material budget estimation are appended. Details of a proposed cabling layout for all the subdetectors are included.

  20. ADVANCED INTEGRATION OF MULTI-SCALE MECHANICS AND WELDING PROCESS SIMULATION IN WELD INTEGRITY ASSESSMENT

    Wilkowski, Gery M.; Rudland, David L.; Shim, Do-Jun; Brust, Frederick W.; Babu, Sundarsanam

    2008-06-30

    -driving force by a factor of 2 depending on strain-hardening, pressure level as a % of SMYS, and flaw size. • From years of experience in circumferential fracture analyses and experimentation, there has not been sufficient integration of work performed for other industries into analogous problems facing the oil and gas pipeline markets. Some very basic concepts and problems solved previously in these fields could have circumvented inconsistencies seen in the stress-based and strain-based analysis efforts. For example, in nuclear utility piping work, more detailed elastic-plastic fracture analyses were always validated in their ability to predict loads and displacements (stresses and strains). The eventual implementation of these methodologies will result in acceleration of the industry adoption of higher-strength line-pipe steels.

  1. Plant communities as drivers of soil respiration: pathways, mechanisms, and significance for global change

    Metcalfe, D. B.; Fisher, R. A.; Wardle, D. A.

    2011-03-01

    , and the importance of trophic interactions and species invasions or extinctions for ecosystem processes. A final, overarching challenge is how to link these observations and drivers across spatio-temporal scales to predict regional or global changes in R over long time periods. A more unified approach to understanding R, which integrates information about plant traits and community dynamics, will be essential for better understanding, simulating and predicting feedbacks to R across terrestrial ecosystems and the earth-climate system.

  2. Formalizing knowledge on international environmental regimes: A first step towards integrating political science in integrated assessments of global environmental change

    de Vos, M.G.; Janssen, P.H.M.; Kok, M.T.J.; Frantzi, S.; Dellas, E.D.; Pattberg, P.H.; Petersen, A.C.; Biermann, F.

    2013-01-01

    International environmental regimes are considered key factors in dealing with global environmental change problems. It is important to understand if and how regimes are effective in tackling these problems, which requires knowledge on their potential impact on these problems as well as on their

  3. A multistep damage recognition mechanism for global genomic nucleotide excision repair.

    Sugasawa, K; Okamoto, T; Shimizu, Y; Masutani, C; Iwai, S; Hanaoka, F

    2001-03-01

    A mammalian nucleotide excision repair (NER) factor, the XPC-HR23B complex, can specifically bind to certain DNA lesions and initiate the cell-free repair reaction. Here we describe a detailed analysis of its binding specificity using various DNA substrates, each containing a single defined lesion. A highly sensitive gel mobility shift assay revealed that XPC-HR23B specifically binds a small bubble structure with or without damaged bases, whereas dual incision takes place only when damage is present in the bubble. This is evidence that damage recognition for NER is accomplished through at least two steps; XPC-HR23B first binds to a site that has a DNA helix distortion, and then the presence of injured bases is verified prior to dual incision. Cyclobutane pyrimidine dimers (CPDs) were hardly recognized by XPC-HR23B, suggesting that additional factors may be required for CPD recognition. Although the presence of mismatched bases opposite a CPD potentiated XPC-HR23B binding, probably due to enhancement of the helix distortion, cell-free excision of such compound lesions was much more efficient than expected from the observed affinity for XPC-HR23B. This also suggests that additional factors and steps are required for the recognition of some types of lesions. A multistep mechanism of this sort may provide a molecular basis for ensuring the high level of damage discrimination that is required for global genomic NER.

  4. Issues Related to University Education in Ukraine in the Context of Globalization, European Integration and Bologna Process

    Maryna V. Bosenko

    2014-03-01

    Full Text Available The article deals with the analysis of issued linked to the development of Ukrainian education in the contexts of globalization, European integration and Bologna Process. The needs for reforms related to the university education in Ukraine is linked with job market and social services, including educational services, globalization of economics and IT technologies: enhancing of socio-economical and pedagogical processes, informatization in society, transition to ‘knowledge societies’, changing the system f values, expanding the core of university education, emergence and distribution of innovative technologies, freedom of choice in electing the university curriculum, fundamentalization and humanization of education etc.

  5. Li-ion Battery Separators, Mechanical Integrity and Failure Mechanisms Leading to Soft and Hard Internal Shorts.

    Zhang, Xiaowei; Sahraei, Elham; Wang, Kai

    2016-09-01

    Separator integrity is an important factor in preventing internal short circuit in lithium-ion batteries. Local penetration tests (nail or conical punch) often produce presumably sporadic results, where in exactly similar cell and test set-ups one cell goes to thermal runaway while the other shows minimal reactions. We conducted an experimental study of the separators under mechanical loading, and discovered two distinct deformation and failure mechanisms, which could explain the difference in short circuit characteristics of otherwise similar tests. Additionally, by investigation of failure modes, we provided a hypothesis about the process of formation of local "soft short circuits" in cells with undetectable failure. Finally, we proposed a criterion for predicting onset of soft short from experimental data.

  6. Bite of the cats: relationships between functional integration and mechanical performance as revealed by mandible geometry.

    Piras, Paolo; Maiorino, Leonardo; Teresi, Luciano; Meloro, Carlo; Lucci, Federico; Kotsakis, Tassos; Raia, Pasquale

    2013-11-01

    Cat-like carnivorous mammals represent a relatively homogeneous group of species whose morphology appears constrained by exclusive adaptations for meat eating. We present the most comprehensive data set of extant and extinct cat-like species to test for evolutionary transformations in size, shape and mechanical performance, that is, von Mises stress and surface traction, of the mandible. Size and shape were both quantified by means of geometric morphometrics, whereas mechanical performance was assessed applying finite element models to 2D geometry of the mandible. Additionally, we present the first almost complete composite phylogeny of cat-like carnivorans for which well-preserved mandibles are known, including representatives of 35 extant and 59 extinct species of Felidae, Nimravidae, and Barbourofelidae. This phylogeny was used to test morphological differentiation, allometry, and covariation of mandible parts within and among clades. After taking phylogeny into account, we found that both allometry and mechanical variables exhibit a significant impact on mandible shape. We also tested whether mechanical performance was linked to morphological integration. Mechanical stress at the coronoid process is higher in sabertoothed cats than in any other clade. This is strongly related to the high degree of covariation within modules of sabertooths mandibles. We found significant correlation between integration at the clade level and per-clade averaged stress values, on both original data and by partialling out interclade allometry from shapes when calculating integration. This suggests a strong interaction between natural selection and the evolution of developmental and functional modules at the clade level.

  7. Processes Adopted to Integrate Intangible Resources in Global Acquisitions among Container Lines: Perceptions of Acquirer and Acquired

    Indika Sigera

    2018-03-01

    Full Text Available The spectrum of strategic co-operations among container lines varies from loose-knitted slot charters, liner conferences, shipping alliances, joint services and consortia, through to mergers and acquisitions (M&As. However, these forms of strategic co-operations have not always been able to achieve the intended synergetic growth resulting from the integration of resources. The Resource Based View (RBV suggests that integrating intangible resources, which are valuable, rare, inimitable and non-substitutable (VRIN, can make a significant contribution to the performance of post strategic co-operations. This research paper investigates the contribution of intangible resources to the post acquisition success six global acquisitions among container lines. The nine senior managers attached to global container lines were the main participants of this study. Five of them represented acquired container lines, four represented acquirer container lines. The paper explains their personnel experience on the processes adopts to integrate intangible resources in acquisitions. Keywords: Merger and Acquisitions, Intangible Resources, Container Lines, Task Integration, Human Integration

  8. Results on an integral inequality of the opial- type | Rauf | Global ...

    Abstract. We obtain integral inequalities which are Opial-type inequalities, mainly by using Jensen's inequality for the case of convex function. Keywords: Integral inequalities, Opial's inequality, Jensen's inequality and convex functions ...

  9. Multiscale mechanical integrity of human supraspinatus tendon in shear after elastin depletion.

    Fang, Fei; Lake, Spencer P

    2016-10-01

    Human supraspinatus tendon (SST) exhibits region-specific nonlinear mechanical properties under tension, which have been attributed to its complex multiaxial physiological loading environment. However, the mechanical response and underlying multiscale mechanism regulating SST behavior under other loading scenarios are poorly understood. Furthermore, little is known about the contribution of elastin to tendon mechanics. We hypothesized that (1) SST exhibits region-specific shear mechanical properties, (2) fiber sliding is the predominant mode of local matrix deformation in SST in shear, and (3) elastin helps maintain SST mechanical integrity by facilitating force transfer among collagen fibers. Through the use of biomechanical testing and multiphoton microscopy, we measured the multiscale mechanical behavior of human SST in shear before and after elastase treatment. Three distinct SST regions showed similar stresses and microscale deformation. Collagen fiber reorganization and sliding were physical mechanisms observed as the SST response to shear loading. Measures of microscale deformation were highly variable, likely due to a high degree of extracellular matrix heterogeneity. After elastase treatment, tendon exhibited significantly decreased stresses under shear loading, particularly at low strains. These results show that elastin contributes to tendon mechanics in shear, further complementing our understanding of multiscale tendon structure-function relationships. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Teaching Children about the Global Economy: Integrating Inquiry with Human Rights

    McCall, Ava L.

    2017-01-01

    Although children are already part of the global economy, they often have little understanding of its influence without explicit instruction. The article focuses on recommendations for teaching elementary students in grades three through five about the global economy utilizing the pedagogical recommendations from the National Council for the…

  11. Measurements of integrated direct, diffuse and global ultraviolet-B radiation

    Utrillas, M.P.; Pedrós, R.; Gandía, S.; Gómez-Amo, J.L.; Estellés, V.; Martínez-Lozano, J.A.

    2015-01-01

    We present the first multiyear set of simultaneous measurements of the global ultraviolet-B radiation and its two components: direct and diffuse. The measurements have been taken with four YES-UVB-1 radiometers: two radiometers to measure the diffuse radiation, one provided with a shadow band and the other with a shadow disk on a Sun tracker; a radiometer to measure the global horizontal radiation; and a Sun-tracking radiometer to measure the direct radiation with an especially designed radiance collimator. The diffuse minute-values measured with both instruments agree within a coefficient correlation of 1.00. The diffuse component represents at least 50% of the global UVB (ultraviolet-B) radiation. The minute values of global UVB irradiance obtained by adding the direct and diffuse components concur with the measured global irradiance. Therefore, the measurement of the direct irradiance enables the estimation of the diffuse component, and gives an insight into the factors that affect its value, especially aerosols. - Highlights: • Simultaneous measurements of global, direct and diffuse UVB (ultraviolet-B) radiation. • The diffuse minute-values are at least 50% of the global ones. • The diffuse measurements are highly correlated to the aerosol load. • The sum of direct + diffuse radiation concur with the measured global.

  12. Communication Policies Reflection on Globalization Process and the Role of Advertisement in Integrated Communication Environment

    ÖZKAN, Abdullah

    2012-01-01

    Globalization process has created important changes and transformations across the world. These political, social, economic and cultural changes have considerably affected communication. The number of mass media instruments have increased, informatics has improved and also reaching information has become easier after the globalization of communication. New communication instruments and environments have been created. Globalised communication has also affected people, reaching the information ...

  13. To assess and control global change in agriculture through ecosystem models integrated into geographic information systems

    Ponti, L.; Iannetta, M.; Gutierrez, A.P.

    2015-01-01

    The transfer of ENEA PBDM (physiologically based demographic models) GIS technology, represents an opportunity to address global change in agriculture on an ecological basis in a local context, be able to provide European governmental agencies the necessary scientific basis for developing effective policies for adaptation to global change, including climate change [it

  14. Integrated assessment of global climate change with learning-by-doing and energy-related research and development

    Mueller-Fuerstenberger, Georg; Stephan, Gunter

    2007-01-01

    This paper presents a small-scale version of an Integrated Assessment Model (IAM) of global climate change, which is based on a global, regionally differentiated computable general equilibrium (CGE) model with endogenous technological change. This model can be viewed as a basic framework for analyzing a broad range of economic issues related to climate change, in particular since technological change is represented in two ways: on the one hand, there is learning-by-doing (LbD) in non-fossil energy supply technologies, and on the other hand there is research and development (R and D)-driven energy-saving technical progress in production. Computational experiments are added for illustrating the role of technological innovation in a world both with and without cooperation in the solution of the global climate problem

  15. Feasibility of integrating other federal information systems into the Global Network of Environment and Technology, GNET{reg_sign}

    NONE

    1998-05-01

    The Global Environment and Technology Enterprise (GETE) of the Global Environment and Technology Foundation (GETF) has been tasked by the US Department of Energy`s (DOE), Federal Energy Technology Center (FETC) to assist in reducing DOE`s cost for the Global Network of Environment and Technology (GNET{reg_sign}). As part of this task, GETE is seeking federal partners to invest in GNET{reg_sign}. The authors are also seeking FETC`s commitment to serve as GNET`s federal agency champion promoting the system to potential agency partners. This report assesses the benefits of partnering with GNET{reg_sign} and provides recommendations for identifying and integrating other federally funded (non-DOE) environmental information management systems into GNET{reg_sign}.

  16. Market-based mechanisms for biodiversity conservation: a review of existing schemes and an outline for a global mechanism

    Alvarado Quesada, I.; Hein, L.G.; Weikard, H.P.

    2014-01-01

    Continuous decline of biodiversity over the past decades suggests that efforts to decrease biodiversity loss have been insufficient. One option to deal with this problem is the use of market-based mechanisms for biodiversity conservation. Several studies have analysed such mechanisms individually,

  17. A universal data access and protocol integration mechanism for smart home

    Shao, Pengfei; Yang, Qi; Zhang, Xuan

    2013-03-01

    With the lack of standardized or completely missing communication interfaces in home electronics, there is no perfect solution to address every aspect in smart homes based on existing protocols and technologies. In addition, the central control unit (CCU) of smart home system working point-to-point between the multiple application interfaces and the underlying hardware interfaces leads to its complicated architecture and unpleasant performance. A flexible data access and protocol integration mechanism is required. The current paper offers a universal, comprehensive data access and protocol integration mechanism for a smart home. The universal mechanism works as a middleware adapter with unified agreements of the communication interfaces and protocols, offers an abstraction of the application level from the hardware specific and decoupling the hardware interface modules from the application level. Further abstraction for the application interfaces and the underlying hardware interfaces are executed based on adaption layer to provide unified interfaces for more flexible user applications and hardware protocol integration. This new universal mechanism fundamentally changes the architecture of the smart home and in some way meets the practical requirement of smart homes more flexible and desirable.

  18. Integrating Global Open Geo-Information for Major Disaster Assessment: A Case Study of the Myanmar Flood

    Suju Li

    2017-07-01

    Full Text Available Major disasters typically impact large areas, cause considerable damages, and result in significant human and economic losses. The timely and accurate estimation of impacts and damages is essential to better understand disaster conditions and to support emergency response operations. Geo-information drawn from various sources at multi spatial-temporal scales can be used for disaster assessments through a synthesis of hazard, exposure, and post disaster information based on pertinent approaches. Along with the increased availability of open sourced data and cooperation initiatives, more global scale geo-information, including global land cover datasets, has been produced and can be integrated with other information for disaster dynamic damage assessment (e.g., impact estimation immediately after a disaster occurs, physical damage assessment during the emergency response stage, and comprehensive assessment following an emergency response. Residential areas and arable lands affected by the flood disaster occurring from July to August 2015 in Myanmar were assessed based on satellite images, GlobeLand30 data, and other global open sourced information as a study case. The results show that integrating global open geo-information could serve as a practical and efficient means of assessing damage resulting from major disasters worldwide, especially at the early emergency response stage.

  19. INTEGRATING DISTRIBUTED WORK: COMPARING TASK DESIGN, COMMUNICATION, AND TACIT COORDINATION MECHANISMS

    Srikanth, K.; Puranam, P.

    2011-01-01

    We investigate coordination strategies in integrating distributed work. In the context of Business Process Offshoring (BPO), we analyze survey data from 126 offshored processes to understand both the sources of difficulty in integrating distributed work as well as how organizations overcome...... on tacit coordination-and theoretically articulate and empirically show that tacit coordination mechanisms are distinct from the well-known duo of coordination strategies: building communication channels or modularizing processes to minimize the need for communication. We discuss implications for the study...

  20. The use of the J* integral for non-linear fracture mechanics

    Hellen, T.K.

    1976-09-01

    The Griffith energy balance criterion, first postulated over 50 years ago, is still the basis of linear elastic fracture mechanics. From this, accurate numerical methods for establishing stress intensity factors and energy release rates have been developed. One such method involves path independent contour integrals about the crack tip. An improved contour integral, designated J* is discussed, and shown to have distinct advantages over others in non-linear strain situations. A number of examples are shown including fractures in thermo-plastic and creep situations. (author)

  1. Integrity evaluation of power plant components by fracture mechanics and related techniques

    Mukherjee, B.; Vanderglas, M.L.; Davies, P.H.

    1982-01-01

    Power plant components can be subject to unexpected failures with serious consequences, unless careful attention is paid to minute crack defects and their possible growth. The Linear Elastic Fracture Mechanics approach to structural integrity evaluation, as it appears in the ASME Code, is discussed. Projects related to material data generation and the development of structural analysis methods to make the above method usable are described. Several integrity-related questions outside the scope of the Code guidelines are documented, concluding with comments on possible future developments

  2. Handedness results from Complementary Hemispheric Dominance, not Global Hemispheric Dominance: Evidence from Mechanically Coupled Bilateral Movements.

    Woytowicz, Elizabeth J; Westlake, Kelly P; Whitall, Jill; Sainburg, Robert L

    2018-05-09

    Two contrasting views of handedness can be described as 1) complementary dominance, in which each hemisphere is specialized for different aspects of motor control, and 2) global dominance, in which the hemisphere contralateral to the dominant arm is specialized for all aspects of motor control. The present study sought to determine which motor lateralization hypothesis best predicts motor performance during common bilateral task of stabilizing an object (e.g. bread) with one hand while applying forces to the object (e.g. slicing) using the other hand. We designed an experimental equivalent of this task, performed in a virtual environment with the unseen arms supported by frictionless air-sleds. The hands were connected by a spring, and the task was to maintain the position of one hand, while moving the other hand to a target. Thus, the reaching hand was required to take account of the spring load to make smooth and accurate trajectories, while the stabilizer hand was required to impede the spring load to keep a constant position. Right-handed subjects performed two task sessions (right hand reach and left hand stabilize; left hand reach and right hand stabilize) with the order of the sessions counterbalanced between groups. Our results indicate a hand by task-component interaction, such that the right hand showed straighter reaching performance while the left showed more stable holding performance. These findings provide support for the complementary dominance hypothesis and suggest that the specializations of each cerebral hemisphere for impedance and dynamic control mechanisms are expressed during bilateral interactive tasks.

  3. Global modeling of flux transfer events: generation mechanism and spacecraft signatures

    Raeder, J.

    2003-04-01

    Magnetic reconnection is a fundamental mode of energy and momentum transfer from the solar wind to the magnetosphere. It is known to occur in different forms depending on solar wind and magnetospheric conditions. In particular, steady reconnection can be distinguished from pulse-like reconnection events which are also known as Flux Transfer Events (FTEs). The formation mechanism of FTEs and their contolling factors remain controversial. We use global MHD simulations of Earth's magnetosphere to show that for southward IMF conditions: a) steady reconnection preferentially occurs without FTEs when the stagnation flow line nearly coincides with the X-line location, which requires small dipole tilt and nearly due southward IMF, b) FTEs occur when the flow/field symmetry is broken, which requires either a large dipole tilt and/or a substantial east-west component of the IMF, c) the predicted spacecraft signature and the repetition frequency of FTEs in the simulations agrees very well with typical observations, lending credibility to the the model, d) the fundamental process that leads to FTE formation is multiple X-line formation caused by the flow and field patterns in the magnetosheath and requires no intrinsic plasma property variations like variable resistivity, e) if the dipole tilt breaks the symmetry FTEs occur only in the winter hemisphere whereas the reconnection signatures in the summer hemisphere are steady with no bipolar FTE-like signatures, f) if the IMF east-west field component breaks the symmetry FTEs occur in both hemispheres, and g) FTE formation depends on sufficient resolution and low diffusion in the model -- coarse resolution and/or high diffusivity lead to flow-through reconnection signatures that appear unphysical given the frequent observation of FTEs.

  4. Integration of Financial Markets in Post Global Financial Crises and Implications for British Financial Sector: Analysis Based on A Panel VAR Model

    Nasir, M; Du, M

    2017-01-01

    This study analyses the dynamics of integration among global financial markets in the context of Global Financial Crisis (2008) by employing a Panel Vector Autoregressive (VAR) model on the monthly data of nine countries and three markets from Jan 2003 to Oct 2015. It was found that there has been a shift in the association among the global financial markets since Global Financial Crisis (GFC).Moreover, the British financial sectors in Post-GFC world clearly showed a change in the association...

  5. Systematic study of imidazoles inhibiting IDO1 via the integration of molecular mechanics and quantum mechanics calculations.

    Zou, Yi; Wang, Fang; Wang, Yan; Guo, Wenjie; Zhang, Yihua; Xu, Qiang; Lai, Yisheng

    2017-05-05

    Indoleamine 2,3-dioxygenase 1 (IDO1) is regarded as an attractive target for cancer immunotherapy. To rationalize the detailed interactions between IDO1 and its inhibitors at the atomic level, an integrated computational approach by combining molecular mechanics and quantum mechanics methods was employed in this report. Specifically, the binding modes of 20 inhibitors was initially investigated using the induced fit docking (IFD) protocol, which outperformed other two docking protocols in terms of correctly predicting ligand conformations. Secondly, molecular dynamics (MD) simulations and MM/PBSA free energy calculations were employed to determine the dynamic binding process and crucial residues were confirmed through close contact analysis, hydrogen-bond analysis and binding free energy decomposition calculations. Subsequent quantum mechanics and nonbonding interaction analysis were carried out to provide in-depth explanations on the critical role of those key residues, and Arg231 and 7-propionate of the heme group were major contributors to ligand binding, which lowed a great amount of interaction energy. We anticipate that these findings will be valuable for enzymatic studies and rational drug design. Copyright © 2017. Published by Elsevier Masson SAS.

  6. Efficient Sustainable Operation Mechanism of Distributed Desktop Integration Storage Based on Virtualization with Ubiquitous Computing

    Hyun-Woo Kim

    2015-06-01

    Full Text Available Following the rapid growth of ubiquitous computing, many jobs that were previously manual have now been automated. This automation has increased the amount of time available for leisure; diverse services are now being developed for this leisure time. In addition, the development of small and portable devices like smartphones, diverse Internet services can be used regardless of time and place. Studies regarding diverse virtualization are currently in progress. These studies aim to determine ways to efficiently store and process the big data generated by the multitude of devices and services in use. One topic of such studies is desktop storage virtualization, which integrates distributed desktop resources and provides these resources to users to integrate into distributed legacy desktops via virtualization. In the case of desktop storage virtualization, high availability of virtualization is necessary and important for providing reliability to users. Studies regarding hierarchical structures and resource integration are currently in progress. These studies aim to create efficient data distribution and storage for distributed desktops based on resource integration environments. However, studies regarding efficient responses to server faults occurring in desktop-based resource integration environments have been insufficient. This paper proposes a mechanism for the sustainable operation of desktop storage (SODS for high operational availability. It allows for the easy addition and removal of desktops in desktop-based integration environments. It also activates alternative servers when a fault occurs within a system.

  7. Assess and control global change in agriculture through ecosystem models integrated in geographic information systems

    Ponti, Luigi; Gutierrez, Andrew Paul; Iannetta, Massimo

    2015-01-01

    ENEA has created, in collaboration with the University of California at Berkeley, the Global Change Biology project that, for the first time, has made available in Europe a technology that can be It used to interpret and effectively manage change Global agriculture. The aim of the project was to provide tools to summarize, manage and analyze data Ecological on the effects of global change in agricultural systems, using traditional Mediterranean crops (Eg. Vineyards and olive) as model systems (http: // cordis.europa.eu/project/rcn/89728_en.html). [it

  8. Integrated 6-DOF Orbit-Attitude Dynamical Modeling and Control Using Geometric Mechanics

    Ling Jiang

    2017-01-01

    Full Text Available The integrated 6-DOF orbit-attitude dynamical modeling and control have shown great importance in various missions, for example, formation flying and proximity operations. The integrated approach yields better performances than the separate one in terms of accuracy, efficiency, and agility. One challenge in the integrated approach is to find a unified representation for the 6-DOF motion with configuration space SE(3. Recently, exponential coordinates of SE(3 have been used in dynamics and control of the 6-DOF motion, however, only on the kinematical level. In this paper, we will improve the current method by adopting exponential coordinates on the dynamical level, by giving the relation between the second-order derivative of exponential coordinates and spacecraft’s accelerations. In this way, the 6-DOF motion in terms of exponential coordinates can be written as a second-order system with a quite compact form, to which a broader range of control theories, such as higher-order sliding modes, can be applied. For a demonstration purpose, a simple asymptotic tracking control law with almost global convergence is designed. Finally, the integrated modeling and control are applied to the body-fixed hovering over an asteroid and verified by a simulation, in which absolute motions of the spacecraft and asteroid are simulated separately.

  9. Mechanical Integrity Issues at MCM-Cs for High Reliability Applications

    Morgenstern, H.A.; Tarbutton, T.J.; Becka, G.A.; Uribe, F.; Monroe, S.; Burchett, S.

    1998-01-01

    During the qualification of a new high reliability low-temperature cofired ceramic (LTCC) multichip module (MCM), two issues relating to the electrical and mechanical integrity of the LTCC network were encountered while performing qualification testing. One was electrical opens after aging tests that were caused by cracks in the solder joints. The other was fracturing of the LTCC networks during mechanical testing. Through failure analysis, computer modeling, bend testing, and test samples, changes were identified. Upon implementation of all these changes, the modules passed testing, and the MCM was placed into production

  10. Transcriptional integration of mitogenic and mechanical signals by Myc and YAP.

    Croci, Ottavio; De Fazio, Serena; Biagioni, Francesca; Donato, Elisa; Caganova, Marieta; Curti, Laura; Doni, Mirko; Sberna, Silvia; Aldeghi, Deborah; Biancotto, Chiara; Verrecchia, Alessandro; Olivero, Daniela; Amati, Bruno; Campaner, Stefano

    2017-10-15

    Mammalian cells must integrate environmental cues to determine coherent physiological responses. The transcription factors Myc and YAP-TEAD act downstream from mitogenic signals, with the latter responding also to mechanical cues. Here, we show that these factors coordinately regulate genes required for cell proliferation. Activation of Myc led to extensive association with its genomic targets, most of which were prebound by TEAD. At these loci, recruitment of YAP was Myc-dependent and led to full transcriptional activation. This cooperation was critical for cell cycle entry, organ growth, and tumorigenesis. Thus, Myc and YAP-TEAD integrate mitogenic and mechanical cues at the transcriptional level to provide multifactorial control of cell proliferation. © 2017 Croci et al.; Published by Cold Spring Harbor Laboratory Press.

  11. GLOBALIZATION AND INTEGRATION INTO THE ECONOMIC AND MONETARY UNION-CHALLENGES FOR BANKS OPERATING IN ROMANIA

    CORALIA EMILIA POPA

    2012-01-01

    Full Text Available This paper aims to present recent evolution, but also the consequences of globalization of the banking sector, considering different approaches of this phenomenon. Over time, the banking field has undergone important changes in both the applicable law of this area, and through the technologies used in satisfying the customers’ needs. The development of international markets has led to new opportunities and challenges for banks that transformed the domestic financial market into an arena where only the best survive and grow. On these grounds and in strict relation to positive and negative effects of globalization, we can speak of a constant evolution of its most important subsystems - the financial subsystems of the global economy. In this paper special importance is given to the banking field, the article presenting arguments through which this complex phenomenon called globalization may have important consequences on financial supervision and regulation.

  12. A Neural Path Integration Mechanism for Adaptive Vector Navigation in Autonomous Agents

    Goldschmidt, Dennis; Dasgupta, Sakyasingha; Wörgötter, Florentin

    2015-01-01

    Animals show remarkable capabilities in navigating their habitat in a fully autonomous and energy-efficient way. In many species, these capabilities rely on a process called path integration, which enables them to estimate their current location and to find their way back home after long-distance...... of autonomous agent navigation, but it also reproduces various aspects of animal navigation. Finally, we discuss how the proposed path integration mechanism may be used as a scaffold for spatial learning in terms of vector navigation.......Animals show remarkable capabilities in navigating their habitat in a fully autonomous and energy-efficient way. In many species, these capabilities rely on a process called path integration, which enables them to estimate their current location and to find their way back home after long...

  13. Calculation of quantum-mechanical system energy spectra using path integrals

    Evseev, A.M.; Dmitriev, V.P.

    1977-01-01

    A solution of the Feynman quantum-mechanical integral connecting a wave function (psi (x, t)) at a moment t+tau (tau → 0) with the wave function at the moment t is provided by complex variable substitution and subsequent path integration. Time dependence of the wave function is calculated by the Monte Carlo method. The Fourier inverse transformation of the wave function by path integration calculated has been applied to determine the energy spectra. Energy spectra are presented of a hydrogen atom derived from wave function psi (x, t) at different x, as well as boson energy spectra of He, Li, and Be atoms obtained from psi (x, t) at X = O

  14. Integrity mechanism for eHealth tele-monitoring system in smart home environment.

    Mantas, Georgios; Lymberopoulos, Dimitrios; Komninos, Nikos

    2009-01-01

    During the past few years, a lot of effort has been invested in research and development of eHealth tele-monitoring systems that will provide many benefits for healthcare delivery from the healthcare provider to the patient's home. However, there is a plethora of security requirements in eHealth tele-monitoring systems. Data integrity of the transferred medical data is one of the most important security requirements that should be satisfied in these systems, since medical information is extremely sensitive information, and even sometimes life threatening information. In this paper, we present a data integrity mechanism for eHealth tele-monitoring system that operates in a smart home environment. Agent technology is applied to achieve data integrity with the use of cryptographic smart cards. Furthermore, the overall security infrastructure and its various components are described.

  15. The mechanisms of integration in conditions of asymmetry of innovative development of the EU

    Oksana OKHRIMENKO

    2017-10-01

    Full Text Available The article concerns to methodological and applied aspects of integration mechanisms functioning in the field of innovation activity of the EU countries. Evolution of models of innovative processes and the detailed forms of integration in their section were investigated. The innovative strategies of EU member states in the context of integration and their effectiveness were analysed. The attention is focused on the transfer of knowledge as the main resource of international cooperation. The advantages of a common innovation environment for participants were considered. The experience of innovative development of the leaders of the countries was highlighted. Requirements for companies planning to innovate or implement innovative projects were disclosed. Preliminary recommendations for eliminating asymmetry in EU innovation development were formulated.

  16. Integrating sustainability in the core business : From global goals to local application

    Frid, Gustav

    2016-01-01

    In 2016, the work towards a more sustainable world increased momentum when the new 17 Sustainable Development Goals (SDG) came into force. Now the SDGs will serve as a global agreement in the work towards ending all forms of poverty, fight inequality and tackle climate change for the next fifteen years. By using standardized Environmental Management Systems (EMS) together with global goals, the author aims on finding ways in how consultancy companies can develop their environmental and sustai...

  17. OPPORTUNITIES AND OBSTACLES TO EUROPEAN INTEGRATION, DEPENDING ON THE FUTURE OF THE GLOBAL SYSTEM

    DUŢĂ ALEXANDRU

    2017-12-01

    Full Text Available The hypothesis of the paper is that the future of the European Union cannot be understood outside of the global context. Here are the main strategic options for the 21st century - Friedman, Attali, Fukuyama and Huntigton. Without denying any possible conflicts, a global war involving the nucleus of the great civilizations is highly unlikely. Our view is that the United States of Europe is a strategically achievable target, bringing some arguments in favor of the advanced hypothesis.

  18. Methods and mechanisms of gettering of silicon structures in the production of integrated circuits

    Pilipenko V. A.

    2013-05-01

    Full Text Available Increasing the degree of integration of hardware components imposes more stringent requirements for the reduction of the concentration of contaminants and oxidation stacking faults in the original silicon wafers with its preservation in the IC manufacturing process cycle. This causes high relevance of the application of gettering in modern microelectronic technology. The existing methods of silicon wafers gettering and the mechanisms of their occurrence are considered.

  19. Quantum Mechanics, Path Integrals and Option Pricing: Reducing the Complexity of Finance

    Baaquie, Belal E.; Coriano, Claudio; Srikant, Marakani

    2002-01-01

    Quantum Finance represents the synthesis of the techniques of quantum theory (quantum mechanics and quantum field theory) to theoretical and applied finance. After a brief overview of the connection between these fields, we illustrate some of the methods of lattice simulations of path integrals for the pricing of options. The ideas are sketched out for simple models, such as the Black-Scholes model, where analytical and numerical results are compared. Application of the method to nonlinear sy...

  20. Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease

    Xu, Wei-Ming; Yang, Kuo; Jiang, Li-Jie; Hu, Jing-Qing; Zhou, Xue-Zhong

    2018-01-01

    Background: Ischemic heart disease (IHD) has been the leading cause of death for several decades globally, IHD patients usually hold the symptoms of phlegm-stasis cementation syndrome (PSCS) as significant complications. However, the underlying molecular mechanisms of PSCS complicated with IHD have not yet been fully elucidated. Materials and Methods: Network medicine methods were utilized to elucidate the underlying molecular mechanisms of IHD phenotypes. Firstly, high-quality IHD-associated genes from both human curated disease-gene association database and biomedical literatures were integrated. Secondly, the IHD disease modules were obtained by dissecting the protein-protein interaction (PPI) topological modules in the String V9.1 database and the mapping of IHD-associated genes to the PPI topological modules. After that, molecular functional analyses (e.g., Gene Ontology and pathway enrichment analyses) for these IHD disease modules were conducted. Finally, the PSCS syndrome modules were identified by mapping the PSCS related symptom-genes to the IHD disease modules, which were further validated by both pharmacological and physiological evidences derived from published literatures. Results: The total of 1,056 high-quality IHD-associated genes were integrated and evaluated. In addition, eight IHD disease modules (the PPI sub-networks significantly relevant to IHD) were identified, in which two disease modules were relevant to PSCS syndrome (i.e., two PSCS syndrome modules). These two modules had enriched pathways on Toll-like receptor signaling pathway (hsa04620) and Renin-angiotensin system (hsa04614), with the molecular functions of angiotensin maturation (GO:0002003) and response to bacterium (GO:0009617), which had been validated by classical Chinese herbal formulas-related targets, IHD-related drug targets, and the phenotype features derived from human phenotype ontology (HPO) and published biomedical literatures. Conclusion: A network medicine

  1. Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease

    Wei-Ming Xu

    2018-01-01

    Full Text Available Background: Ischemic heart disease (IHD has been the leading cause of death for several decades globally, IHD patients usually hold the symptoms of phlegm-stasis cementation syndrome (PSCS as significant complications. However, the underlying molecular mechanisms of PSCS complicated with IHD have not yet been fully elucidated.Materials and Methods: Network medicine methods were utilized to elucidate the underlying molecular mechanisms of IHD phenotypes. Firstly, high-quality IHD-associated genes from both human curated disease-gene association database and biomedical literatures were integrated. Secondly, the IHD disease modules were obtained by dissecting the protein-protein interaction (PPI topological modules in the String V9.1 database and the mapping of IHD-associated genes to the PPI topological modules. After that, molecular functional analyses (e.g., Gene Ontology and pathway enrichment analyses for these IHD disease modules were conducted. Finally, the PSCS syndrome modules were identified by mapping the PSCS related symptom-genes to the IHD disease modules, which were further validated by both pharmacological and physiological evidences derived from published literatures.Results: The total of 1,056 high-quality IHD-associated genes were integrated and evaluated. In addition, eight IHD disease modules (the PPI sub-networks significantly relevant to IHD were identified, in which two disease modules were relevant to PSCS syndrome (i.e., two PSCS syndrome modules. These two modules had enriched pathways on Toll-like receptor signaling pathway (hsa04620 and Renin-angiotensin system (hsa04614, with the molecular functions of angiotensin maturation (GO:0002003 and response to bacterium (GO:0009617, which had been validated by classical Chinese herbal formulas-related targets, IHD-related drug targets, and the phenotype features derived from human phenotype ontology (HPO and published biomedical literatures.Conclusion: A network medicine

  2. Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease.

    Xu, Wei-Ming; Yang, Kuo; Jiang, Li-Jie; Hu, Jing-Qing; Zhou, Xue-Zhong

    2018-01-01

    Background: Ischemic heart disease (IHD) has been the leading cause of death for several decades globally, IHD patients usually hold the symptoms of phlegm-stasis cementation syndrome (PSCS) as significant complications. However, the underlying molecular mechanisms of PSCS complicated with IHD have not yet been fully elucidated. Materials and Methods: Network medicine methods were utilized to elucidate the underlying molecular mechanisms of IHD phenotypes. Firstly, high-quality IHD-associated genes from both human curated disease-gene association database and biomedical literatures were integrated. Secondly, the IHD disease modules were obtained by dissecting the protein-protein interaction (PPI) topological modules in the String V9.1 database and the mapping of IHD-associated genes to the PPI topological modules. After that, molecular functional analyses (e.g., Gene Ontology and pathway enrichment analyses) for these IHD disease modules were conducted. Finally, the PSCS syndrome modules were identified by mapping the PSCS related symptom-genes to the IHD disease modules, which were further validated by both pharmacological and physiological evidences derived from published literatures. Results: The total of 1,056 high-quality IHD-associated genes were integrated and evaluated. In addition, eight IHD disease modules (the PPI sub-networks significantly relevant to IHD) were identified, in which two disease modules were relevant to PSCS syndrome (i.e., two PSCS syndrome modules). These two modules had enriched pathways on Toll-like receptor signaling pathway (hsa04620) and Renin-angiotensin system (hsa04614), with the molecular functions of angiotensin maturation (GO:0002003) and response to bacterium (GO:0009617), which had been validated by classical Chinese herbal formulas-related targets, IHD-related drug targets, and the phenotype features derived from human phenotype ontology (HPO) and published biomedical literatures. Conclusion: A network medicine

  3. Some comments about the J1 integral criterion in post yield fracture mechanics

    Roche, R.L.

    1977-01-01

    Several criteria have been proposed for Post Yield Fracture Mechanics. One of the most interesting ones is the J 1 integral. When the behaviour of material is elastic (even non-linear) it can be shown that J 1 is not path dependent (for a straight crack without thermal stresses). For this reason, it may be considered that J 1 characterizes the crack tip singularity. Extension is easy to deformation-type elastic plastic material, but there is no proof of path independence for flow-type plastic material (incremental plasticity or creep). Experimental results are often given as a proof of J 1 criterion validity, but there is no experimental value of a contour integral and assumptions are made in the use of experimental results. The main assumption implies that the received mechanical work (strain energy) is not dependent on the loading history (is only dependent on mechanical state). A general method to assess J 1 path dependence can be founded on the 'defect vector' (or driving force) concept. It can be shown that the resultant of defects included in a volumne is the J integral on the surface surrounding the volume (and L for the moment). In order to have an empirical idea of the J 1 path independence, it is possible to make computations with finite elements method. Some results are given and it seems that no noticeable path dependence is seen with simple shapes and radial (proportional) loading. A few cases with complex way of loading are also studied. (Auth.)

  4. Global Value Chain Integration and Productivity : Evidence from Enterprise Surveys in Namibia, South Africa, and Swaziland

    Winkler, Deborah; Farole, Thomas

    2015-01-01

    In order to adequately measure a firm’s participation in GVCs in this context, it is important to first identify the different forms through which GVC integration can affect domestic firms’ productivity. Integrating a country’s domestic suppliers into GVCs increases the possibility for productivity gains through exporting to a buyer abroad or supplying to a multinational in the country. Bu...

  5. Integrating information systems : linking global business goals to local database applications

    Dignum, F.P.M.; Houben, G.J.P.M.

    1999-01-01

    This paper describes a new approach to design modern information systems that offer an integrated access to the data and knowledge that is available in local applications. By integrating the local data management activities into one transparent information distribution process, modern organizations

  6. Global thermo-mechanical effects from a KBS-3 type repository. Summary report

    Hakami, E.; Olofsson, Stig-Olof; Hakami, H.; Israelsson, Jan

    1998-04-01

    The objective of this study has been to identify the global thermomechanical effects in the bedrock hosting a nuclear waste repository - i.e. the effects at large distances from the repository. Numerical thermomechanical modeling was performed in several steps, beginning with elastic continuum models and followed by distinct element models (3DEC), in which fracture zones are explicitly simulated. The number of fracture zones, the heat intensity of the waste, the material properties of the rock mass and the boundary conditions of the models were varied in different simulations. The results from the numerical modeling show that the principal stresses increase near the repository. The maximum stress obtained for the main model is 44 MPa and occurs at the repository level after about 100 years of deposition. Due to thermal expansion, the rock mass displaces upward, and the maximum heave at the ground surface after 1000 years is calculated to be 16 cm. In the area close to the ground surface, above the center of the repository, the horizontal stresses reduce, causing the rock to yield in tension down to a depth of about 80 m. In correspondence with the stress changes, the fracture zones show opening normal displacements at shallow depths and closing normal displacements and shearing at the repository level. The maximum displacements of the different fracture zones are 0.3-2.5 cm for closing, 0.0-0.8 cm for opening and 0.2-2.2 cm for shearing. Another important input parameter for the analysis is the Young's modulus of the rock mass. In the main model, a value of 30 GPa is assumed. Higher values of Young's modulus give larger thermo-mechanical effects. Other changes of the properties considered give minor changes of the rock mass behavior. All multi-level repository layouts give rise to higher temperatures than the single-level layout, causing the compressive stresses to increase more at the repository level. Fracture zone displacements caused by different layouts are

  7. An analytical procedure to evaluate electronic integrals for molecular quantum mechanical calculations

    Mundim, Kleber C.

    2004-01-01

    Full text: We propose an alternative methodology for the calculation of electronic integrals, through an analytical function based on the generalized Gaussian function (q Gaussian), where a single q Gaussian replaces the usual linear combination of Gaussian functions for different basis set. Moreover, the integrals become analytical functions of the interatomic distances. Therefore, when estimating certain quantities such as molecular energy, g Gaussian avoid new calculations of the integrals: they are simply another value of the corresponding function. The procedure proposed here is particularly advantageous, when compared with the usual one, because it reduces drastically the number of two-electronic integrals used in the construction of the Fock matrix, enabling the use of the quantum mechanics in the description of macro-molecular systems. This advantage increases when the size of the molecular systems become larger and more complex. While in the usual approach CPU time increases with n4, in the one proposed here the CPU time scales linearly with n. This catastrophic dependence of the rank the Hamiltonian or Fock matrix with n4 two-electron integrals is a severe bottleneck for petaFLOPS computing time. Its is important to emphasize that this methodology is equally applicable to systems of any sizes, including biomolecules, solid materials and solutions, within the HF, post-HF and DFT theories. (author)

  8. Design of articulated mechanisms with a degree of freedom constraint using global optimization

    Kawamoto, Atsushi; Stolpe, Mathias

    2004-01-01

    This paper deals with design of articulated mechanisms using a truss ground structure representation. The considered mechanism design problem is to maximize the output displacement for a given input force by choosing a prescribed number of truss elements out of all the available elements, so...... that the resultant mechanism has one mechanical degree of freedom when supported in a statically determinate manner. The mechanical degree of freedom constraint is included since it is essential for obtaining a proper articulated mechanism design. The Green-Lagrange strain measure is used to accommodate for large...

  9. Hierarchical Kinematic Modelling and Optimal Design of a Novel Hexapod Robot with Integrated Limb Mechanism

    Guiyang Xin

    2015-09-01

    Full Text Available This paper presents a novel hexapod robot, hereafter named PH-Robot, with three degrees of freedom (3-DOF parallel leg mechanisms based on the concept of an integrated limb mechanism (ILM for the integration of legged locomotion and arm manipulation. The kinematic model plays an important role in the parametric optimal design and motion planning of robots. However, models of parallel mechanisms are often difficult to obtain because of the implicit relationship between the motions of actuated joints and the motion of a moving platform. In order to derive the kinematic equations of the proposed hexapod robot, an extended hierarchical kinematic modelling method is proposed. According to the kinematic model, the geometrical parameters of the leg are optimized utilizing a comprehensive objective function that considers both dexterity and payload. PH-Robot has distinct advantages in accuracy and load ability over a robot with serial leg mechanisms through the former's comparison of performance indices. The reachable workspace of the leg verifies its ability to walk and manipulate. The results of the trajectory tracking experiment demonstrate the correctness of the kinematic model of the hexapod robot.

  10. A compact skeletal mechanism for n -dodecane with optimized semi-global low-temperature chemistry for diesel engine simulations

    Yao, Tong; Pei, Yuanjiang; Zhong, Bei-Jing; Som, Sibendu; Lu, Tianfeng; Luo, Kai Hong

    2017-03-01

    A skeletal mechanism with 54 species and 269 reactions was developed to predict pyrolysis and oxidation of n-dodecane as a diesel fuel surrogate involving both high-temperature (high-T) and low-temperature (low-T) conditions. The skeletal mechanism was developed from a semi-detailed mechanism developed at the University of Southern California (USC). Species and reactions for high-T pyrolysis and oxidation of C5-C12 were reduced by using reaction flow analysis (RFA), isomer lumping, and then merged into a skeletal C0-C4 core to form a high-T sub-mechanism. Species and lumped semi-global reactions for low-T chemistry were then added to the high-T sub-mechanism and a 54-species skeletal mechanism is obtained. The rate parameters of the low-T reactions were tuned against a detailed mechanism by the Lawrence Livermore National Laboratory (LLNL), as well as the Spray A flame experimental data, to improve the prediction of ignition delay at low-T conditions, while the high-T chemistry remained unchanged. The skeletal mechanism was validated for auto-ignition, perfectly stirred reactors (PSR), flow reactors and laminar premixed flames over a wide range of flame conditions. The skeletal mechanism was then employed to simulate three-dimensional turbulent spray flames at compression ignition engine conditions and validated against experimental data from the Engine Combustion Network (ECN).

  11. The heart as a self-regulating system: integration of homeodynamic mechanisms.

    Kresh, J Y; Armour, J A

    1997-04-01

    In the past the study of mechanical and electrical properties of the heart has been disjointed with minimal overlap and unification. The fact remains that these features are tightly coupled and central to the functioning heart. The maintenance of adequate cardiac output relies upon the highly integrated autoregulatory mechanisms and modulation of cardiac myocyte function. Regional ventricular mechanics and energetics are dependent upon muscle fiber stress-strain rate, the passive properties of myocardial collagen matrix, adequate vascular perfusion, transcapillary transport and electrical activation pattern. Intramural hydraulic "loading" is regulated by coronary arterial and venous dynamics. All of these components are under the constant influence of intrinsic cardiac and extracardiac autonomic neurons, as well as circulating hormones. A brief overview of the putative regulation of these various components is presented in this paper.

  12. The contribution of biomass burning to global warming: An integrated assessment

    Lashof, D.A.

    1991-01-01

    An analysis of studies of emissions form biomass burning suggests that while biomass burning is less significant than fossil fuel combustion on global basis, it is a major contributor to the greenhouse gas buildup, responsible for perhaps 10% to 15% of the total forcing from current emissions. Uncertainties about emissions and the relative impact of different gases are large, yielding a range of 5% to 30%. Nonetheless, biomass burning is probably the dominant source of greenhouse gases in some regions. A comprehensive policy to limit global climate change must, therefore, address biomass burning

  13. The Integration Aspects of Activities of the Companies in the Oil and Gas Industry Sector in the Context of Globalization

    Panevnyk Tetiana M.

    2016-05-01

    Full Text Available The article considers both the dynamics and the structure of oil and gas production in Ukraine, situation of the oil and gas companies at the current stage of globalization of the world economy have been covered. The main problems impacting the functioning of the domestic industry sector have been identified, including the lack of effectiveness of the existing integration processes. The world trends and patterns of integration processes have been considered. It has been determined that the oil and gas industry sector leaders are the multinational companies that actively use integration in their practices. The current trends in creating integration linkages in different parts of the process chain in the oil and gas industry have been identified. Influence by large corporations of the innovative type on the creation of a favorable investment climate has been confirmed, as well as conducting their own policies of expansion in the overseas markets. On the basis of studying the foreign experience, expediency of development of the oil and gas sector enterprises by activating integration processes has been substantiated. Priorities and possibilities for further functioning of enterprises in the the oil and gas industry sector have been identified

  14. INSTITUTIONAL GLOBALIZATION AS A SYSTEM OF INTEGRATION THE PHENOMENON OF THE POSTMODERN DEVELOPMENT

    V. V. Zinchenko

    2015-12-01

    Full Text Available Purpose. Institutionalism is gaining strength as a dominant point of view on the world. Its philosophical basis is the postulate of the uncertainty of the development, which comes to replace the neoclassical certainty characteristic of industrial society. The postulate of uncertainty is closely connected with the idea of subjectivization and individualization of post-industrial society. All these were very important components of the new paradigm, although they do not exhaust the problem. In the heart of postmodernism is a mass identity as a spiritual substance, while the more recently mass of people to realize themselves as natural and social beings. Person has absolute freedom in the acceptance and rejection of culture and civilization; it is pluralistic in their actions and in their consciousness. It is the subject of history and it should be creative, fluent mastering all the achievements of culture. Methodology. The dialogue system of the Postmodern, which is the basis of human communication with another person, human with society is a model of convergent formation of the world community and world economy. The same model of rationalism and adequate industrial society is a monologue, which is easily builds a bridge to violence, even if it is carried out in the name of the man behind him and the pathos of the exaltation of man as the bearer of unlimited creation possibilities. However, it is very important not just to modify rationalism, and to understand the origins of civilization. Scientific novelty. The postmodern era begins is not easy. Modern defending, using all their reserves: public thirst for justice, the priority of rationality (at least in the economy, monologist public agencies and politicians in contrast to the dialogic postmodern imperative modality in the spiritual existence of man instead the freedom. Finally, the world of the story is set a trap – the anthropological paradigm of the globalization ideology formation. In

  15. Technical note. A review of the mechanical integrity of the canister

    Segle, Peter

    2012-01-01

    Background: The Swedish Radiation Safety Authority (SSM) reviews the Swedish Nuclear Fuel Company's (SKB) applications under the Act on Nuclear Activities (SFS 1984:3) for the construction and operation of a repository for spent nuclear fuel and for an encapsulation facility. As part of the review, SSM commissions consultants to carry out work in order to obtain information on specific issues. The results from the consultants' tasks are reported in SSM's Technical Note series. Objectives of the project: This project is part of SSM:s review of SKB:s license application for final disposal of spent nuclear fuel. The assignment concerns a review of the mechanical integrity of the canister. Summary by the author: An introductory review of SR-Site has been conducted with respect to the mechanical integrity of the canister. The review is focused on the copper canister and the nodular cast iron insert. Review results show that a number of loads and loading scenarios for the copper canister has not been analysed by SKB. The importance of sufficient creep ductility of the copper material and sufficient ductility and fracture toughness of the nodular cast iron material is pointed out in the review. A sensitivity study is suggested where the impact of these properties on the mechanical integrity of the canister is investigated. It is also suggested that potential damage mechanisms influencing these properties are further investigated. SKB's modelling of creep elongation at rupture under repository conditions is questioned. Needs for complementary information from SKB for the main review of SR-Site is listed. A list of review topics for SSM is also suggested

  16. Novel in situ mechanical testers to enable integrated metal surface micro-machines.

    Follstaedt, David Martin; de Boer, Maarten Pieter; Kotula, Paul Gabriel; Hearne, Sean Joseph; Foiles, Stephen Martin; Buchheit, Thomas Edward; Dyck, Christopher William

    2005-10-01

    The ability to integrate metal and semiconductor micro-systems to perform highly complex functions, such as RF-MEMS, will depend on developing freestanding metal structures that offer improved conductivity, reflectivity, and mechanical properties. Three issues have prevented the proliferation of these systems: (1) warpage of active components due to through-thickness stress gradients, (2) limited component lifetimes due to fatigue, and (3) low yield strength. To address these issues, we focus on developing and implementing techniques to enable the direct study of the stress and microstructural evolution during electrodeposition and mechanical loading. The study of stress during electrodeposition of metal thin films is being accomplished by integrating a multi-beam optical stress sensor into an electrodeposition chamber. By coupling the in-situ stress information with ex-situ microstructural analysis, a scientific understanding of the sources of stress during electrodeposition will be obtained. These results are providing a foundation upon which to develop a stress-gradient-free thin film directly applicable to the production of freestanding metal structures. The issues of fatigue and yield strength are being addressed by developing novel surface micromachined tensile and bend testers, by interferometry, and by TEM analysis. The MEMS tensile tester has a ''Bosch'' etched hole to allow for direct viewing of the microstructure in a TEM before, during, and after loading. This approach allows for the quantitative measurements of stress-strain relations while imaging dislocation motion, and determination of fracture nucleation in samples with well-known fatigue/strain histories. This technique facilitates the determination of the limits for classical deformation mechanisms and helps to formulate a new understanding of the mechanical response as the grain sizes are refined to a nanometer scale. Together, these studies will result in a science

  17. Integrating rock mechanics issues with repository design through design process principles and methodology

    Bieniawski, Z.T.

    1996-01-01

    A good designer needs not only knowledge for designing (technical know-how that is used to generate alternative design solutions) but also must have knowledge about designing (appropriate principles and systematic methodology to follow). Concepts such as open-quotes design for manufactureclose quotes or open-quotes concurrent engineeringclose quotes are widely used in the industry. In the field of rock engineering, only limited attention has been paid to the design process because design of structures in rock masses presents unique challenges to the designers as a result of the uncertainties inherent in characterization of geologic media. However, a stage has now been reached where we are be able to sufficiently characterize rock masses for engineering purposes and identify the rock mechanics issues involved but are still lacking engineering design principles and methodology to maximize our design performance. This paper discusses the principles and methodology of the engineering design process directed to integrating site characterization activities with design, construction and performance of an underground repository. Using the latest information from the Yucca Mountain Project on geology, rock mechanics and starter tunnel design, the current lack of integration is pointed out and it is shown how rock mechanics issues can be effectively interwoven with repository design through a systematic design process methodology leading to improved repository performance. In essence, the design process is seen as the use of design principles within an integrating design methodology, leading to innovative problem solving. In particular, a new concept of open-quotes Design for Constructibility and Performanceclose quotes is introduced. This is discussed with respect to ten rock mechanics issues identified for repository design and performance

  18. Structural integrity and failure mechanisms of a smart piezoelectric actuator under a cyclic bending mode

    Woo, Sung-Choong; Goo, Nam Seo

    2008-01-01

    Information on the onset and evolution of damage within materials is essential for guaranteeing the integrity of actuator systems. The authors have evaluated the structural integrity and the failure mechanisms of smart composite actuators with a PZT ceramic plate under electric cyclic loading. For this, two kinds of actuators, actuator 1 and actuator 2, were manufactured. Prior to the main testing, performance testing was performed on the actuators to determine their resonant frequencies. Electric cyclic tests were conducted up to twenty million cycles. An acoustic emission technique was used for monitoring the damage evolution in real time. We observed the extent of the damage after testing using scanning electron microscopy and reflected optical microscopy to support characteristics in the acoustic emission behavior that corresponded to specific types of damage mechanisms. It was shown that the initial damage mechanism of the smart composite actuator under electric cyclic loading originated from the transgranular micro-fatigue damage in the PZT ceramic layer. With increasing cycles, a local intergranular crack initiated and developed onto the surface of the PZT ceramic layer or propagated into the internal layer. Finally, short-circuiting led to the electric breakdown of the actuator. These results were different depending on the drive frequencies and the configuration of the actuators. Moreover, we differentiated between the aforementioned damage mechanisms via AE signal pattern analyses based on the primary frequency and the waveform. From our results, we conclude that the drive frequency and the existence of a protecting layer are dominant factors in the structural integrity of the smart composite actuator

  19. Global model of the upper atmosphere with a variable step of integration in latitude

    Namgaladze, A.A.; Martynenko, O.V.; Namgaladze, A.N.

    1996-01-01

    New version of model for the Earth thermosphere, ionosphere and protonosphere with increased spatial distribution, realized at personal computer, is developed. Numerical solution algorithm for modeling equations solution, which makes it possible to apply variable (depending on latitude) integrating pitch by latitude and to increase hereby the model latitude resolutions in the latitude zones of interest. Comparison of the model calculational results of ionosphere and thermosphere parameters, accomplished with application of different integrating pitches by geomagnetic latitude, is conducted. 10 refs.; 3 figs

  20. Tracking Global Fund HIV/AIDS resources used for sexual and reproductive health service integration: case study from Ethiopia.

    Mookherji, Sangeeta; Ski, Samantha; Huntington, Dale

    2015-05-27

    The Global Fund to Fight AIDS, Tuberculosis & Malaria (GF) strives for high value for money, encouraging countries to integrate synergistic services and systems strengthening to maximize investments. The GF needs to show how, and how much, its grants support more than just HIV/AIDS, TB and malaria. Sexual and Reproductive Health (SRH) has been part of HIV/AIDS grants since 2007. Previous studies showed the GF PBF system does not allow resource tracking for SRH integration within HIV/AIDS grants. We present findings from a resource tracking case study using primary data collected at country level. Ethiopia was the study site. We reviewed data from four HIV/AIDS grants from January 2009-June 2011 and categorized SDAs and activities as directly, indirectly, or not related to SRH integration. Data included: GF PBF data; financial, performance, in-depth interview and facility observation data from Ethiopia. All HIV/AIDS grants in Ethiopia support SRH integration activities (12-100%). Using activities within SDAs, expenditures directly supporting SRH integration increased from 25% to 66% for the largest HIV/AIDS grant, and from 21% to 34% for the smaller PMTCT-focused grant. Using SDAs to categorize expenditures underestimated direct investments in SRH integration; activity-based categorization is more accurate. The important finding is that primary data collection could not resolve the limitations in using GF GPR data for resource tracking. The remedy is to require existing activity-based budgets and expenditure reports as part of PBF reporting requirements, and make them available in the grant portfolio database. The GF should do this quickly, as it is a serious shortfall in the GF guiding principle of transparency. Showing high value for money is important for maximizing impact and replenishments. The Global Fund should routinely track HIV/AIDs grant expenditures to disease control, service integration, and overall health systems strengthening. The current PBF system

  1. Improving global health governance to combat counterfeit medicines: a proposal for a UNODC-WHO-Interpol trilateral mechanism.

    Mackey, Tim K; Liang, Bryan A

    2013-10-31

    Perhaps no greater challenge exists for public health, patient safety, and shared global health security, than fake/falsified/fraudulent, poor quality unregulated drugs, also commonly known as "counterfeit medicines", now endemic in the global drug supply chain. Counterfeit medicines are prevalent everywhere, from traditional healthcare settings to unregulated sectors, including the Internet. These dangerous medicines are expanding in both therapeutic and geographic scope, threatening patient lives, leading to antimicrobial resistance, and profiting criminal actors. Despite clear global public health threats, surveillance for counterfeit medicines remains extremely limited, with available data pointing to an increasing global criminal trade that has yet to be addressed appropriately. Efforts by a variety of public and private sector entities, national governments, and international organizations have made inroads in combating this illicit trade, but are stymied by ineffectual governance and divergent interests. Specifically, recent efforts by the World Health Organization, the primary international public health agency, have failed to adequately incorporate the broad array of stakeholders necessary to combat the problem. This has left the task of combating counterfeit medicines to other organizations such as UN Office of Drugs and Crime and Interpol in order to fill this policy gap. To address the current failure of the international community to mobilize against the worldwide counterfeit medicines threat, we recommend the establishment of an enhanced global health governance trilateral mechanism between WHO, UNODC, and Interpol to leverage the respective strengths and resources of these organizations. This would allow these critical organizations, already engaged in the fight against counterfeit medicines, to focus on and coordinate their respective domains of transnational crime prevention, public health, and law enforcement field operations. Specifically, by

  2. Proof of integrity and ageing management of mechanical components in nuclear power plants

    Roos, E.; Herter, K.-H.; Kockelmann, H.; Schuler, X.

    2005-01-01

    Demands and requirements for a safe operation of mechanical components during the whole operation life time (plant life management) to assure aging phenomena (aging management) and to prove the integrity (prove of integrity, e.g. in order to exclude large breaks) can be found in guidelines, codes and standards. In the present paper a general concept to proof the integrity as part of the ageing management of pressurized components and systems is presented. The concept is based on the actual material characteristics, the actual as-built configurations and the design of the components and systems including the knowledge of possible failure mechanism during operation. An important part of the assessment is the leak before break behavior and the break preclusion concept. Based on essential research results the developed procedures and methodologies for the assessment of the critical crack sizes as well as the critical loading conditions are reported and discussed. In detail the following aspects have to be treated: (a) evaluation of the as-built status of quality (design, construction, material, fabrication; results of recurrent non destructive examinations up to now, operational experience); (b) determination of the relevant loading conditions by means of in-service monitoring (monitoring of the mode of operation, the water chemistry, the mechanical and thermal stresses, the dynamic loading), emergency and faulted condition loads as specified; (c) evaluation of the actual status of quality with respect to the relevant loading conditions (stress analysis-limitation of the stresses; fatigue analysis-determination of the usage factor; fracture mechanics analysis-determination of crack growth, critical crack sizes and loading conditions); (d) evaluation and extent of the in-service monitoring and recurrent inspections to guarantee the succeeding operation (recurrent non destructive examination - minimum detectable flaw sizes, examination area, examination intervals; leak

  3. Plumbing the global carbon cycle: Integrating inland waters into the terrestrial carbon budget

    Cole, J.; Prairie, Y.T.; Caraco, N.; McDowell, W.H.; Tranvil, L.; Striegl, R.G.; Duarte, C.M.; Kortelainen, P.; Downing, J.A.; Middelburg, J.J.; Melack, J.

    2007-01-01

    Because freshwater covers such a small fraction of the Earth’s surface area, inland freshwater ecosystems (particularly lakes, rivers, and reservoirs) have rarely been considered as potentially important quantitative components of the carbon cycle at either global or regional scales. By taking

  4. Knowledge that Counts in a Global Community: Exploring the Contribution of Integrated Curriculum

    Rennie, Leonie J.; Venville, Grady; Wallace, John

    2011-01-01

    As the third millennium progresses, we are faced with increasing pressures relating to climate change and the sustainability of life on Earth. Concerned citizens are realizing that the responsibility to respond is both local and global. There is an increasing sense of urgency about the need to reform the processes of schooling and curriculum to…

  5. THE IMPACT OF EUROPEAN INTEGRATION AND FINANCIAL GLOBALIZATION ON PRUDENTIAL SUPERVISION

    Filip Angela Maria

    2009-05-01

    Full Text Available As a result of the financial market globalization during the last two decades, the conventional barriers between financial activities have diminished. This led to the emergence of financial holdings that operate both in the banking sector and on the stock

  6. The Global Positioning System and Its Integration into College Geography Curricula.

    Wikle, Thomas A.; Lambert, Dean P.

    1996-01-01

    Introduces global positioning system (GPS) technology to nonspecialist geographers and recommends a framework for implementing GPS instructional modules in college geography courses. GPS was developed as a worldwide satellite-based system by the U.S. Department of Defense to simplify and improve military and civilian navigation and positioning.…

  7. Academic Integrity, Remix Culture, Globalization: A Canadian Case Study of Student and Faculty Perceptions of Plagiarism

    Evans-Tokaryk, Tyler

    2014-01-01

    This article presents the results of a case study at a Canadian university that used a combination of surveys and focus groups to explore faculty members' and students' perceptions of plagiarism. The research suggests that the globalization of education and remix culture have contributed to competing and contradictory understandings of plagiarism…

  8. A global energy network? The expansion and integration of non-triad national oil companies

    de Graaff, N.A.

    2011-01-01

    It is widely perceived that the rising influence of state-owned energy companies from outside the traditional triad (USA, EU, Japan) is transforming the structure of the global energy market and generating a new wave of resource-nationalism. There is, however, little empirical analysis of how this

  9. Integration in the Global South: What Role for IBSA Dialogue Forum?

    Mehmet ÖZKAN

    2011-01-01

    Full Text Available Recently we have seen that the middle-sized states are coming together inseveral forums. The WTO meetings and India-Brazil-South Africa (IBSA dialogueforum are among those to be cited. Such groupings are mainly economyorientedand whether they will have political output needs to be seen, however,in the future if globalization goes in a similar way as today, we might see moregroupings. Those groupings should be seen as reactions to unjust and exclusiveglobalization. The IBSA Dialogue Forum members have enhanced their relationseconomically by signing bilateral trade agreements and acting together oneconomic issues in global forums. If they can hold together, they are creating amarket more than ¼ of global population and, if successful, it has a chance tobe the engine of growth in the South. Moreover if they can create the biggestmarket in the South, they would also be influential in the being of the voiceof the South. In that sense, this paper addresses the possible ways to developrelations between the IBSA members and economic development in the South,furthermore, implication of the IBSA on global governance and developmentcan be as critical as its contribution to economic development, since the globalgoverning bodies have legitimacy crisis.

  10. HMP-1/α-catenin promotes junctional mechanical integrity during morphogenesis.

    Thanh Thi Kim Vuong-Brender

    Full Text Available Adherens junctions (AJs are key structures regulating tissue integrity and maintaining adhesion between cells. During morphogenesis, junctional proteins cooperate closely with the actomyosin network to drive cell movement and shape changes. How the junctions integrate the mechanical forces in space and in time during an in vivo morphogenetic event is still largely unknown, due to a lack of quantitative data. To address this issue, we inserted a functional Fluorescence Resonance Energy Transfer (FRET-based force biosensor within HMP-1/α-catenin of Caenorhabditis elegans. We find that the tension exerted on HMP-1 has a cell-specific distribution, is actomyosin-dependent, but is regulated differently from the tension on the actin cortex during embryonic elongation. By using time-lapse analysis of mutants and tissue-specific rescue experiments, we confirm the role of VAB-9/Claudin as an actin bundle anchor. Nevertheless, the tension exerted on HMP-1 did not increase in the absence of VAB-9/Claudin, suggesting that HMP-1 activity is not upregulated to compensate for loss of VAB-9. Our data indicate that HMP-1 does not modulate HMR-1/E-cadherin turnover, is required to recruit junctional actin but not stress fiber-like actin bundles. Altogether, our data suggest that HMP-1/α-catenin acts to promote the mechanical integrity of adherens junctions.

  11. Book Review: Jandl, Thomas, Vietnam in the Global Economy – The Dy-namics of Integration, Decentralization and Contested Politics

    Adam Fforde

    2014-01-01

    Full Text Available Book Review of the Monograph: Thomas Jandl (2013, Vietnam in the Global Economy – The Dynamics of Integration, Decentralization and Contested Politics. Plymouth: Lexington Books, ISBN 978-0-7391-7786-0, 312 pages

  12. Environmental market failures. Are there any local market-based corrective mechanisms for global problems?

    Ayres, R.U.

    1997-01-01

    The paper reviews various policy tools that have been discussed in the literature, including legal, administrative and fiscal (tax) schemes, as well as tradeable emission permits and concludes that none of them are really suitable for dealing with global problems. An alternative is suggested, namely the use of tradeable individual consumption quotas for traded commodities at the national level, to be extended later to the global level by trading quotas among nations (assuming agreement can be reached on the basis for determining quotas). 28 refs

  13. A new integrated and homogenized global monthly land surface air temperature dataset for the period since 1900

    Xu, Wenhui; Li, Qingxiang; Jones, Phil; Wang, Xiaolan L.; Trewin, Blair; Yang, Su; Zhu, Chen; Zhai, Panmao; Wang, Jinfeng; Vincent, Lucie; Dai, Aiguo; Gao, Yun; Ding, Yihui

    2018-04-01

    A new dataset of integrated and homogenized monthly surface air temperature over global land for the period since 1900 [China Meteorological Administration global Land Surface Air Temperature (CMA-LSAT)] is developed. In total, 14 sources have been collected and integrated into the newly developed dataset, including three global (CRUTEM4, GHCN, and BEST), three regional and eight national sources. Duplicate stations are identified, and those with the higher priority are chosen or spliced. Then, a consistency test and a climate outlier test are conducted to ensure that each station series is quality controlled. Next, two steps are adopted to assure the homogeneity of the station series: (1) homogenized station series in existing national datasets (by National Meteorological Services) are directly integrated into the dataset without any changes (50% of all stations), and (2) the inhomogeneities are detected and adjusted for in the remaining data series using a penalized maximal t test (50% of all stations). Based on the dataset, we re-assess the temperature changes in global and regional areas compared with GHCN-V3 and CRUTEM4, as well as the temperature changes during the three periods of 1900-2014, 1979-2014 and 1998-2014. The best estimates of warming trends and there 95% confidence ranges for 1900-2014 are approximately 0.102 ± 0.006 °C/decade for the whole year, and 0.104 ± 0.009, 0.112 ± 0.007, 0.090 ± 0.006, and 0.092 ± 0.007 °C/decade for the DJF (December, January, February), MAM, JJA, and SON seasons, respectively. MAM saw the most significant warming trend in both 1900-2014 and 1979-2014. For an even shorter and more recent period (1998-2014), MAM, JJA and SON show similar warming trends, while DJF shows opposite trends. The results show that the ability of CMA-LAST for describing the global temperature changes is similar with other existing products, while there are some differences when describing regional temperature changes.

  14. A reductionist perspective on quantum statistical mechanics: Coarse-graining of path integrals.

    Sinitskiy, Anton V; Voth, Gregory A

    2015-09-07

    Computational modeling of the condensed phase based on classical statistical mechanics has been rapidly developing over the last few decades and has yielded important information on various systems containing up to millions of atoms. However, if a system of interest contains important quantum effects, well-developed classical techniques cannot be used. One way of treating finite temperature quantum systems at equilibrium has been based on Feynman's imaginary time path integral approach and the ensuing quantum-classical isomorphism. This isomorphism is exact only in the limit of infinitely many classical quasiparticles representing each physical quantum particle. In this work, we present a reductionist perspective on this problem based on the emerging methodology of coarse-graining. This perspective allows for the representations of one quantum particle with only two classical-like quasiparticles and their conjugate momenta. One of these coupled quasiparticles is the centroid particle of the quantum path integral quasiparticle distribution. Only this quasiparticle feels the potential energy function. The other quasiparticle directly provides the observable averages of quantum mechanical operators. The theory offers a simplified perspective on quantum statistical mechanics, revealing its most reductionist connection to classical statistical physics. By doing so, it can facilitate a simpler representation of certain quantum effects in complex molecular environments.

  15. Mechanical behaviour of textile-reinforced thermoplastics with integrated sensor network components

    Hufenbach, W.; Adam, F.; Fischer, W.-J.; Kunadt, A.; Weck, D.

    2011-01-01

    Highlights: → Consideration of two types of integrated bus systems for textile-reinforced thermoplastics with embedded sensor networks. → Specimens with bus systems made of flexible printed circuit boards show good mechanical performance compared to the reference. → Inhomogeneous interface and reduced stiffnesses and strengths for specimens with bus systems basing on single copper wires. -- Abstract: The embedding of sensor networks into textile-reinforced thermoplastics enables the design of function-integrative lightweight components suitable for high volume production. In order to investigate the mechanical behaviour of such functionalised composites, two types of bus systems are selected as exemplary components of sensor networks. These elements are embedded into glass fibre-reinforced polypropylene (GF/PP) during the layup process of unconsolidated weft-knitted GF/PP-preforms. Two fibre orientations are considered and orthotropic composite plates are manufactured by hot pressing technology. Micrograph investigations and computer tomography analyses show different interface qualities between the thermoplastic composite and the two types of bus systems. Mechanical tests under tensile and flexural loading indicate a significant influence of the embedded bus system elements on the structural stiffness and strength.

  16. Numerical Modelling of Mechanical Integrity of the Copper-Cast Iron Canister. A Literature Review

    Lanru Jing

    2004-04-01

    This review article presents a summary of the research works on the numerical modelling of the mechanical integrity of the composite copper-cast iron canisters for the final disposal of Swedish nuclear wastes, conducted by SKB and SKI since 1992. The objective of the review is to evaluate the outstanding issues existing today about the basic design concepts and premises, fundamental issues on processes, properties and parameters considered for the functions and requirements of canisters under the conditions of a deep geological repository. The focus is placed on the adequacy of numerical modelling approaches adopted in regards to the overall mechanical integrity of the canisters, especially the initial state of canisters regarding defects and the consequences of their evolution under external and internal loading mechanisms adopted in the design premises. The emphasis is the stress-strain behaviour and failure/strength, with creep and plasticity involved. Corrosion, although one of the major concerns in the field of canister safety, was not included

  17. A reductionist perspective on quantum statistical mechanics: Coarse-graining of path integrals

    Sinitskiy, Anton V.; Voth, Gregory A.

    2015-01-01

    Computational modeling of the condensed phase based on classical statistical mechanics has been rapidly developing over the last few decades and has yielded important information on various systems containing up to millions of atoms. However, if a system of interest contains important quantum effects, well-developed classical techniques cannot be used. One way of treating finite temperature quantum systems at equilibrium has been based on Feynman’s imaginary time path integral approach and the ensuing quantum-classical isomorphism. This isomorphism is exact only in the limit of infinitely many classical quasiparticles representing each physical quantum particle. In this work, we present a reductionist perspective on this problem based on the emerging methodology of coarse-graining. This perspective allows for the representations of one quantum particle with only two classical-like quasiparticles and their conjugate momenta. One of these coupled quasiparticles is the centroid particle of the quantum path integral quasiparticle distribution. Only this quasiparticle feels the potential energy function. The other quasiparticle directly provides the observable averages of quantum mechanical operators. The theory offers a simplified perspective on quantum statistical mechanics, revealing its most reductionist connection to classical statistical physics. By doing so, it can facilitate a simpler representation of certain quantum effects in complex molecular environments

  18. Forests and global warming mitigation in Brazil: opportunities in the Brazilian forest sector for responses to global warming under the 'clean development mechanism''

    Fearnside, P.M.

    1999-01-01

    The Kyoto Protocol created global warming response opportunities through the clean development mechanism that allow countries like Brazil to receive investments from companies and governments wishing to offset their emissions of greenhouse gases. Brazil has a special place in strategies for combating global warming because its vast areas of tropical forest represent a potentially large source of emissions if deforested. A number of issues need to be settled to properly assign credit for carbon in the types of options presented by the Brazilian forest sector. These include definition of the units of carbon (permanent sequestration versus carbon-ton-years, the latter being most appropriate for forest options), the means of crediting forest reserve establishment, adoption of discounting or other time-preference weighting for carbon, definition of the accounting method (avoided emissions versus stock maintenance), and mechanism to allow program contributions to be counted, rather than restricting consideration to free-standing projects. Silvicultural plantations offer opportunities for carbon benefits, but have high social impacts in the Brazilian context. Plantations also inherently compete with deforestation reduction options for funds. Forest management has been proposed as a global warming response option, but the assignment of any value to time makes this unattractive in terms of carbon benefits. However, reduced-impact logging can substantially reduce emissions over those from traditional logging practices. Slowing deforestation is the major opportunity offered by Brazil. Slowing deforestation will require understanding its causes and creating functional models capable of generating land-use change scenarios with and without different policy changes and other activities. Brazil already has a number of programs designed to slow deforestation, but the continued rapid loss of forest highlights the vast gulf that exists between the magnitude of the problem and the

  19. Development and validation of a new global well-being outcomes rating scale for integrative medicine research

    Bell Iris R

    2004-01-01

    Full Text Available Abstract Background Researchers are finding limitations of currently available disease-focused questionnaire tools for outcome studies in complementary and alternative medicine/integrative medicine (CAM/IM. Methods Three substudies investigated the new one-item visual analogue Arizona Integrative Outcomes Scale (AIOS, which assesses self-rated global sense of spiritual, social, mental, emotional, and physical well-being over the past 24 hours and the past month. The first study tested the scale's ability to discriminate unhealthy individuals (n = 50 from healthy individuals (n = 50 in a rehabilitation outpatient clinic sample. The second study examined the concurrent validity of the AIOS by comparing ratings of global well-being to degree of psychological distress as measured by the Brief Symptom Inventory (BSI in undergraduate college students (N = 458. The third study evaluated the relationships between the AIOS and positively- and negatively-valenced tools (Positive and Negative Affect Scale and the Positive States of Mind Scale in a different sample of undergraduate students (N = 62. Results Substudy (i Rehabilitation patients scored significantly lower than the healthy controls on both forms of the AIOS and a current global health rating. The AIOS 24-hours correlated moderately and significantly with global health (patients r = 0.50; controls r = 0.45. AIOS 1-month correlations with global health were stronger within the controls (patients r = 0.36; controls r = 0.50. Controls (r = 0.64 had a higher correlation between the AIOS 24-hour and 1-month forms than did the patients (r = 0.33, which is consistent with the presumptive improvement in the patients' condition over the previous 30 days in rehabilitation. Substudy (ii In undergraduate students, AIOS scores were inversely related to distress ratings, as measured by the global severity index on the BSI (rAIOS24h = -0.42, rAIOS1month = -0.40. Substudy (iii AIOS scores were significantly

  20. Introduction to quantum mechanics Schrödinger equation and path integral

    Müller-Kirsten, H J W

    2012-01-01

    This text on quantum mechanics begins by covering all the main topics of an introduction to the subject. It then concentrates on newer developments. In particular it continues with the perturbative solution of the Schrodinger equation for various potentials and thereafter with the introduction and evaluation of their path integral counterparts. Considerations of the large order behavior of the perturbation expansions show that in most applications these are asymptotic expansions. The parallel consideration of path integrals requires the evaluation of these around periodic classical configurations, the fluctuation equations about which lead back to specific wave equations. The period of the classical configurations is related to temperature, and permits transitions to the thermal domain to be classified as phase transitions. In this second edition of the text important applications and numerous examples have been added. In particular, the chapter on the Coulomb potential has been extended to include an introdu...

  1. Cortical mechanisms for trans-saccadic memory and integration of multiple object features

    Prime, Steven L.; Vesia, Michael; Crawford, J. Douglas

    2011-01-01

    Constructing an internal representation of the world from successive visual fixations, i.e. separated by saccadic eye movements, is known as trans-saccadic perception. Research on trans-saccadic perception (TSP) has been traditionally aimed at resolving the problems of memory capacity and visual integration across saccades. In this paper, we review this literature on TSP with a focus on research showing that egocentric measures of the saccadic eye movement can be used to integrate simple object features across saccades, and that the memory capacity for items retained across saccades, like visual working memory, is restricted to about three to four items. We also review recent transcranial magnetic stimulation experiments which suggest that the right parietal eye field and frontal eye fields play a key functional role in spatial updating of objects in TSP. We conclude by speculating on possible cortical mechanisms for governing egocentric spatial updating of multiple objects in TSP. PMID:21242142

  2. Molecular mechanisms responsive to dehydration may impact the invasiveness of perennial weeds under global climate change

    Leafy spurge is an invasive perennial weed in the great plains of the US and Canada. The ability of this herbaceous weed to regenerate new shoot growth from an abundance of crown and root buds after severe abiotic stress is critical for survival. Due to its adaptable and aggressive nature, global cl...

  3. Mechanisms of private meta-governance: an analysis of global private governance for sustainable development

    Glasbergen, P.

    2011-01-01

    One of the main characteristics of global governance for sustainable development is its fragmentation. Next to public regulations, there are often many private regulations in force on the same issue, which are induced by collaborations between businesses and NGOs. Traditionally, it is assumed that

  4. Global-scale combustion sources of organic aerosols: sensitivity to formation and removal mechanisms

    Tsimpidi, Alexandra P.; Karydis, Vlassis A.; Pandis, Spyros N.; Lelieveld, Jos

    2017-06-01

    Organic compounds from combustion sources such as biomass burning and fossil fuel use are major contributors to the global atmospheric load of aerosols. We analyzed the sensitivity of model-predicted global-scale organic aerosols (OA) to parameters that control primary emissions, photochemical aging, and the scavenging efficiency of organic vapors. We used a computationally efficient module for the description of OA composition and evolution in the atmosphere (ORACLE) of the global chemistry-climate model EMAC (ECHAM/MESSy Atmospheric Chemistry). A global dataset of aerosol mass spectrometer (AMS) measurements was used to evaluate simulated primary (POA) and secondary (SOA) OA concentrations. Model results are sensitive to the emission rates of intermediate-volatility organic compounds (IVOCs) and POA. Assuming enhanced reactivity of semi-volatile organic compounds (SVOCs) and IVOCs with OH substantially improved the model performance for SOA. The use of a hybrid approach for the parameterization of the aging of IVOCs had a small effect on predicted SOA levels. The model performance improved by assuming that freshly emitted organic compounds are relatively hydrophobic and become increasingly hygroscopic due to oxidation.

  5. Protective Effects and Mechanism of Puerarin on Learning-Memory Disorder after Global Cerebral Ischemia-Reperfusion Injury in Rats

    WU Hai-qin; GUO He-na; WANG Hu-qing; CHANG Ming-ze; ZHANG Gui-lian; ZHAO Ying-xian

    2009-01-01

    Objective: To observe the effect of puerarin on the learning-memory disorder after global cerebral ischemia-reperfusion injury in rats, and to explore its mechanism of action. Methods: The global cerebral ischemia-reperfusion injury model was established using the modified Pulsinelli four-vessel occlusion in Sprague-Dawley rats. Rats were intraperitoneally injected with puerarin (100 mg/kg) 1 h before ischemia and once every 6 h afterwards. The learning-memory ability was evaluated by the passive avoidance test. The dynamic changes of the cell counts of apoptosis and positive expression of Bcl-2 in the hippocampus CA1 region were determined by the TUNEL and immunohistochemical methods, respectively. Results: (1) Compared with the reperfusion group, the step through latency (STL) in the passive avoidance test in the puerarin group was prolonged significantly (P<0.01). (2) The apoptotic neurons were injured most severely on the 3rd day in the hippocampal CA1 region after global ischemia and reperfusion. In the pueradn group, the number of apoptotic cells decreased at respective time points after ischemia-reperfusion (P<0.01). (3) The level of positive expression of Bcl-2 varied according to the duration of reperfusion and the peak level occurred on day 1 in the hippocampal CA1 region after global cerebral ischemia. Compared with the reperfusion group, the expression of Bcl-2 in the pueradn group was up-regulated at the respective time points after ischemia raperfusion (P<0.01), reaching the peak on day 1. Conclusions: Puerarin could improve the learning-memory ability after global cerebral ischemia and reperfusion in rats. The protective mechanism might be related to the effect of inhibiting or delaying the cell apoptosis through up-regulating the expression of Bcl-2 after ischemia and reperfusion.

  6. The Global Network of Isotopes in Rivers (GNIR): Integration of Stable Water Isotopes in Riverine Research and Management

    Halder, J.; Terzer, S.; Wassenaar, L.; Araguas, L.; Aggarwal, P.

    2015-01-01

    Rivers play a crucial role in the global water cycle as watershed-integrating hydrological conduits for returning terrestrial precipitation, runoff, surface and groundwater, as well as melting snow and ice back to the world’s oceans. The IAEA Global Network of Isotopes in Rivers (GNIR) is the coherent extension of the IAEA Global Network for Isotopes in Precipitation (GNIP) and aims to fill the informational data gaps between rainfall and river discharge. Whereas the GNIP has been surveying the stable hydrogen and oxygen isotopes, and tritium composition in precipitation, the objective of GNIR is to accumulate and disseminate riverine isotope data. We introduce the new global database of riverine water isotopes and evaluate its current long-term data holdings with the objective to improve the application of water isotopes and to inform water managers and researchers. An evaluation of current GNIR database holdings confirmed that seasonal variations of the stable water isotope composition in rivers are closely coupled to precipitation and snow-melt water run-off on a global scale. Rivers could be clustered on the basis of seasonal variations in their isotope composition and latitude. Results showed furthermore, that there were periodic phases within each of these groupings and additional modelling exercises allowed a priori prediction of the seasonal variability as well as the isotopic composition of stable water isotopes in rivers. This predictive capacity will help to improve existing and new sampling strategies, help to validate and interpret riverine isotope data, and identify important catchment processes. Hence, the IAEA promulgates and supports longterm hydrological isotope observation networks and the application of isotope studies complementary with conventional hydrological, water quality, and ecological studies. (author)

  7. Integrating genome-based informatics to modernize global disease monitoring, information sharing, and response

    Aarestrup, Frank Møller; Brown, Eric W; Detter, Chris

    2012-01-01

    The rapid advancement of genome technologies holds great promise for improving the quality and speed of clinical and public health laboratory investigations and for decreasing their cost. The latest generation of genome DNA sequencers can provide highly detailed and robust information on disease...... typing methods to provide point-of-care clinical diagnosis and other essential information for quicker and better treatment of patients. Provided there is free-sharing of information by all clinical and public health laboratories, these genomic tools could spawn a global system of linked databases......-causing microbes, and in the near future these technologies will be suitable for routine use in national, regional, and global public health laboratories. With additional improvements in instrumentation, these next- or third-generation sequencers are likely to replace conventional culture-based and molecular...

  8. Integrated Marketing Strategies of German Companies : Start-Ups vs. Global Brands

    Kostin, Irina

    2016-01-01

    The purpose of this bachelor's thesis is to find out and analyze different marketing strategies of German fashion companies. The main part is comparing relatively young start-up companies to established companies and analyzing to what extent the strategies differ. The methodology used in this paper were semi-structured expert interviews with German start-up companies. The results were analyzed and compared to the secondary research on the big global German companies. The findings showed that ...

  9. Integration of Extended MHD and Kinetic Effects in Global Magnetosphere Models

    Germaschewski, K.; Wang, L.; Maynard, K. R. M.; Raeder, J.; Bhattacharjee, A.

    2015-12-01

    Computational models of Earth's geospace environment are an important tool to investigate the science of the coupled solar-wind -- magnetosphere -- ionosphere system, complementing satellite and ground observations with a global perspective. They are also crucial in understanding and predicting space weather, in particular under extreme conditions. Traditionally, global models have employed the one-fluid MHD approximation, which captures large-scale dynamics quite well. However, in Earth's nearly collisionless plasma environment it breaks down on small scales, where ion and electron dynamics and kinetic effects become important, and greatly change the reconnection dynamics. A number of approaches have recently been taken to advance global modeling, e.g., including multiple ion species, adding Hall physics in a Generalized Ohm's Law, embedding local PIC simulations into a larger fluid domain and also some work on simulating the entire system with hybrid or fully kinetic models, the latter however being to computationally expensive to be run at realistic parameters. We will present an alternate approach, ie., a multi-fluid moment model that is derived rigorously from the Vlasov-Maxwell system. The advantage is that the computational cost remains managable, as we are still solving fluid equations. While the evolution equation for each moment is exact, it depends on the next higher-order moment, so that truncating the hiearchy and closing the system to capture the essential kinetic physics is crucial. We implement 5-moment (density, momentum, scalar pressure) and 10-moment (includes pressure tensor) versions of the model, and use local approximations for the heat flux to close the system. We test these closures by local simulations where we can compare directly to PIC / hybrid codes, and employ them in global simulations using the next-generation OpenGGCM to contrast them to MHD / Hall-MHD results and compare with observations.

  10. Leach behavior and mechanical-integrity studies of irradiated Epicor-II waste products

    Barletta, R.E.; Swyler, K.J.; Chan, S.F.; Davis, R.E.

    1982-01-01

    The leachability of Cs and Sr from cement solidified ion exchange media claimed to be representative of the Epicor-II prefilters (D-mix) is presented. The Cs and Sr release is significantly lower than that typically observed for organic ion exchange resin/cement composites. The effect of radiation up to a total dose of 10 7 Gy upon the leachability and mechanical integrity (as measured by MCC-11) of D-mix/cement composites has been investigated. No deleterious effects were found. 6 figures

  11. Multilevel Mechanisms of Implementation Strategies in Mental Health: Integrating Theory, Research, and Practice

    2015-01-01

    A step toward the development of optimally effective, efficient, and feasible implementation strategies that increase evidence-based treatment integration in mental health services involves identification of the multilevel mechanisms through which these strategies influence implementation outcomes. This article (a) provides an orientation to, and rationale for, consideration of multilevel mediating mechanisms in implementation trials, and (b) systematically reviews randomized controlled trials that examined mediators of implementation strategies in mental health. Nine trials were located. Mediation-related methodological deficiencies were prevalent and no trials supported a hypothesized mediator. The most common reason was failure to engage the mediation target. Discussion focuses on directions to accelerate implementation strategy development in mental health. PMID:26474761

  12. Global optimization for integrated design and control of computationally expensive process models

    Egea, J.A.; Vries, D.; Alonso, A.A.; Banga, J.R.

    2007-01-01

    The problem of integrated design and control optimization of process plants is discussed in this paper. We consider it as a nonlinear programming problem subject to differential-algebraic constraints. This class of problems is frequently multimodal and "costly" (i.e., computationally expensive to

  13. Decomposing passenger transport futures : Comparing results of global integrated assessment models

    Edelenbosch, O. Y.; McCollum, D. L.; van Vuuren, Detlef; Bertram, C.; Carrara, S.; Daly, H.; Fujimori, S.; Kitous, A.; Kyle, P.; Ó Broin, E.; Karkatsoulis, P.; Sano, F.

    The transport sector is growing fast in terms of energy use and accompanying greenhouse gas emissions. Integrated assessment models (IAMs) are used widely to analyze energy system transitions over a decadal time frame to help inform and evaluating international climate policy. As part of this, IAMs

  14. An Integrated Signaling-Encryption Mechanism to Reduce Error Propagation in Wireless Communications: Performance Analyses

    Olama, Mohammed M [ORNL; Matalgah, Mustafa M [ORNL; Bobrek, Miljko [ORNL

    2015-01-01

    Traditional encryption techniques require packet overhead, produce processing time delay, and suffer from severe quality of service deterioration due to fades and interference in wireless channels. These issues reduce the effective transmission data rate (throughput) considerably in wireless communications, where data rate with limited bandwidth is the main constraint. In this paper, performance evaluation analyses are conducted for an integrated signaling-encryption mechanism that is secure and enables improved throughput and probability of bit-error in wireless channels. This mechanism eliminates the drawbacks stated herein by encrypting only a small portion of an entire transmitted frame, while the rest is not subject to traditional encryption but goes through a signaling process (designed transformation) with the plaintext of the portion selected for encryption. We also propose to incorporate error correction coding solely on the small encrypted portion of the data to drastically improve the overall bit-error rate performance while not noticeably increasing the required bit-rate. We focus on validating the signaling-encryption mechanism utilizing Hamming and convolutional error correction coding by conducting an end-to-end system-level simulation-based study. The average probability of bit-error and throughput of the encryption mechanism are evaluated over standard Gaussian and Rayleigh fading-type channels and compared to the ones of the conventional advanced encryption standard (AES).

  15. A variable stiffness mechanism for steerable percutaneous instruments: integration in a needle.

    De Falco, Iris; Culmone, Costanza; Menciassi, Arianna; Dankelman, Jenny; van den Dobbelsteen, John J

    2018-06-04

    Needles are advanced tools commonly used in minimally invasive medical procedures. The accurate manoeuvrability of flexible needles through soft tissues is strongly determined by variations in tissue stiffness, which affects the needle-tissue interaction and thus causes needle deflection. This work presents a variable stiffness mechanism for percutaneous needles capable of compensating for variations in tissue stiffness and undesirable trajectory changes. It is composed of compliant segments and rigid plates alternately connected in series and longitudinally crossed by four cables. The tensioning of the cables allows the omnidirectional steering of the tip and the stiffness tuning of the needle. The mechanism was tested separately under different working conditions, demonstrating a capability to exert up to 3.6 N. Afterwards, the mechanism was integrated into a needle, and the overall device was tested in gelatine phantoms simulating the stiffness of biological tissues. The needle demonstrated the capability to vary deflection (from 11.6 to 4.4 mm) and adapt to the inhomogeneity of the phantoms (from 21 to 80 kPa) depending on the activation of the variable stiffness mechanism. Graphical abstract ᅟ.

  16. Materials and noncoplanar mesh designs for integrated circuits with linear elastic responses to extreme mechanical deformations.

    Kim, Dae-Hyeong; Song, Jizhou; Choi, Won Mook; Kim, Hoon-Sik; Kim, Rak-Hwan; Liu, Zhuangjian; Huang, Yonggang Y; Hwang, Keh-Chih; Zhang, Yong-wei; Rogers, John A

    2008-12-02

    Electronic systems that offer elastic mechanical responses to high-strain deformations are of growing interest because of their ability to enable new biomedical devices and other applications whose requirements are impossible to satisfy with conventional wafer-based technologies or even with those that offer simple bendability. This article introduces materials and mechanical design strategies for classes of electronic circuits that offer extremely high stretchability, enabling them to accommodate even demanding configurations such as corkscrew twists with tight pitch (e.g., 90 degrees in approximately 1 cm) and linear stretching to "rubber-band" levels of strain (e.g., up to approximately 140%). The use of single crystalline silicon nanomaterials for the semiconductor provides performance in stretchable complementary metal-oxide-semiconductor (CMOS) integrated circuits approaching that of conventional devices with comparable feature sizes formed on silicon wafers. Comprehensive theoretical studies of the mechanics reveal the way in which the structural designs enable these extreme mechanical properties without fracturing the intrinsically brittle active materials or even inducing significant changes in their electrical properties. The results, as demonstrated through electrical measurements of arrays of transistors, CMOS inverters, ring oscillators, and differential amplifiers, suggest a valuable route to high-performance stretchable electronics.

  17. Global Strategy Implementation at the Business Unit Level: Operational Capabilities and Administrative Mechanisms

    Kendall Roth; David M Schweiger; Allen J Morrison

    1991-01-01

    The study examines the impact of internationally strategy on organizational design and the influence of the organizational design on effectiveness at the business unit level. The empirical findings are based on survey responses from eighty-two business units competing in global industries. The findings are supportive of the contingency notion which suggests that business unit effectiveness is a function of the fit between the international strategy and the organizational design.© 1991 JIBS. J...

  18. Korea’s Trade Strategies for Mega Free Trade Agreements in Regional and Global Economic Integration

    Sang-Chul Park

    2016-12-01

    Full Text Available Korea has developed rapidly since the 1960s. It is one of the four Asian tiger economies and a good model for developing countries. Korea shows the world how a developing country can develop its economy rapidly and become industrialized. Its development strategy has mainly been an export-oriented trade policy. As a result, its trade volume grew from $1 billion in 1966 to $1 trillion in 2011, which is a 1,000-fold increase within five decades. Since 2011, Korea has become one of seven countries with a trade volume over $1 trillion. However, the Korean economy has experienced turbulence as well as positive growth. It underwent severe economic crises such as the Asian financial crisis in 1997 and the global financial crisis in 2008. Its economy has been extremely vulnerable to the external economic environment, although it has improved and strengthened, particularly since the global financial crisis. During those two crises, the government carried out an appropriate trade policy with a strategic approach to upgrade its industrial structure and competitiveness in global markets. This article comprehensively discusses Korean trade policy and strategy over the last five decades, and how its national economy has developed rapidly. It also explores how the government sets its strategic targets in Asia and the Asia Pacific region. It considers two mega free trade agreements (FTAs — the Regional Comprehensive Economic Partnership and the Trans-Pacific Partnership — as new opportunities for further development. Therefore, it is wise to analyze these regional mega FTAs in order to maximize the national interest.

  19. Marginalization: A Revisitation With Integration of Scholarship on Globalization, Intersectionality, Privilege, Microaggressions, and Implicit Biases.

    Hall, Joanne M; Carlson, Kelly

    2016-01-01

    In 1994, the concept of marginalization was explored in an article in Advances in Nursing Science. This is a revisitation of the concept incorporating new scholarship. This update is founded on feminism, postcolonialism, critical race theory, and discourse deconstruction, all viewpoints that have been explicated in nursing. The purpose of this analysis is to look at new scholarship and concepts useful to applying marginalization in nursing knowledge development from the standpoint of Bourdieu's macro, meso, and micro levels. New scholarship includes globalization, intersectionality, privilege, microaggressions, and implicit bias. Implications for decreasing health disparities through this new scholarship are discussed.

  20. Analysis of global warming stabilization scenarios. The Asian-Pacific Integrated Model

    Kainuma, Mikiko; Morita, Tsuneyuki; Masui, Toshihiko; Takahashi, Kiyoshi; Matsuoka, Yuzuru

    2004-01-01

    This paper analyzes the economic and climatic impacts of the EMF 19 emission scenarios. A reference scenario, three emission scenarios targeting 550 ppmv atmospheric concentration, and three tax scenarios are analyzed. The profiles of energy consumption and economic losses of each policy scenario are compared to the reference scenario. The model also estimates that global mean temperature will increase 1.7-2.9 C in 2100, and the sea level will rise 40-51 cm, compared to the 1990 levels under the EMF scenarios. Impacts on food productivity and malaria infection are estimated to be very severe in some countries in the Asian region

  1. A direct comparison of local-global integration in autism and other developmental disorders: implications for the central coherence hypothesis.

    Bernardino, Inês; Mouga, Susana; Almeida, Joana; van Asselen, Marieke; Oliveira, Guiomar; Castelo-Branco, Miguel

    2012-01-01

    The weak central coherence hypothesis represents one of the current explanatory models in Autism Spectrum Disorders (ASD). Several experimental paradigms based on hierarchical figures have been used to test this controversial account. We addressed this hypothesis by testing central coherence in ASD (n = 19 with intellectual disability and n = 20 without intellectual disability), Williams syndrome (WS, n = 18), matched controls with intellectual disability (n = 20) and chronological age-matched controls (n = 20). We predicted that central coherence should be most impaired in ASD for the weak central coherence account to hold true. An alternative account includes dorsal stream dysfunction which dominates in WS. Central coherence was first measured by requiring subjects to perform local/global preference judgments using hierarchical figures under 6 different experimental settings (memory and perception tasks with 3 distinct geometries with and without local/global manipulations). We replicated these experiments under 4 additional conditions (memory/perception*local/global) in which subjects reported the correct local or global configurations. Finally, we used a visuoconstructive task to measure local/global perceptual interference. WS participants were the most impaired in central coherence whereas ASD participants showed a pattern of coherence loss found in other studies only in four task conditions favoring local analysis but it tended to disappear when matching for intellectual disability. We conclude that abnormal central coherence does not provide a comprehensive explanation of ASD deficits and is more prominent in populations, namely WS, characterized by strongly impaired dorsal stream functioning and other phenotypic traits that contrast with the autistic phenotype. Taken together these findings suggest that other mechanisms such as dorsal stream deficits (largest in WS) may underlie impaired central coherence.

  2. A direct comparison of local-global integration in autism and other developmental disorders: implications for the central coherence hypothesis.

    Inês Bernardino

    Full Text Available The weak central coherence hypothesis represents one of the current explanatory models in Autism Spectrum Disorders (ASD. Several experimental paradigms based on hierarchical figures have been used to test this controversial account. We addressed this hypothesis by testing central coherence in ASD (n = 19 with intellectual disability and n = 20 without intellectual disability, Williams syndrome (WS, n = 18, matched controls with intellectual disability (n = 20 and chronological age-matched controls (n = 20. We predicted that central coherence should be most impaired in ASD for the weak central coherence account to hold true. An alternative account includes dorsal stream dysfunction which dominates in WS. Central coherence was first measured by requiring subjects to perform local/global preference judgments using hierarchical figures under 6 different experimental settings (memory and perception tasks with 3 distinct geometries with and without local/global manipulations. We replicated these experiments under 4 additional conditions (memory/perception*local/global in which subjects reported the correct local or global configurations. Finally, we used a visuoconstructive task to measure local/global perceptual interference. WS participants were the most impaired in central coherence whereas ASD participants showed a pattern of coherence loss found in other studies only in four task conditions favoring local analysis but it tended to disappear when matching for intellectual disability. We conclude that abnormal central coherence does not provide a comprehensive explanation of ASD deficits and is more prominent in populations, namely WS, characterized by strongly impaired dorsal stream functioning and other phenotypic traits that contrast with the autistic phenotype. Taken together these findings suggest that other mechanisms such as dorsal stream deficits (largest in WS may underlie impaired central coherence.

  3. Integrated assessment of global water scarcity over the 21st century - Part 2: Climate change mitigation policies

    Hejazi, M. I.; Edmonds, J.; Clarke, L.; Kyle, P.; Davies, E.; Chaturvedi, V.; Eom, J.; Wise, M.; Patel, P.; Calvin, K.

    2013-03-01

    We investigate the effects of emission mitigation policies on water scarcity both globally and regionally using the Global Change Assessment Model (GCAM), a leading community integrated assessment model of energy, agriculture, climate, and water. Three climate policy scenarios with increasing mitigation stringency of 7.7, 5.5, and 4.2 W m-2 in year 2095 (equivalent to the SRES A2, B2, and B1 emission scenarios, respectively), under two carbon tax regimes (a universal carbon tax (UCT) which includes land use change emissions, and a fossil fuel and industrial emissions carbon tax (FFICT) which excludes land use change emissions) are analyzed. The results are compared to a baseline scenario (i.e. no climate change mitigation policy) with radiative forcing reaching 8.8 W m-2 (equivalent to the SRES A1Fi emission scenario) by 2095. When compared to the baseline scenario and maintaining the same baseline socioeconomic assumptions, water scarcity declines under a UCT mitigation policy but increases with a FFICT mitigation scenario by the year 2095 particularly with more stringent climate mitigation targets. The decreasing trend with UCT policy stringency is due to substitution from more water-intensive to less water-intensive choices in food and energy production, and in land use. Under the FFICT scenario, water scarcity is projected to increase driven by higher water demands for bio-energy crops. This study implies an increasingly prominent role for water availability in future human decisions, and highlights the importance of including water in integrated assessment of global change. Future research will be directed at incorporating water shortage feedbacks in GCAM to better understand how such stresses will propagate across the various human and natural systems in GCAM.

  4. Conference on support mechanisms evolution and renewable energies integration in France and in Germany markets

    Praetorius, Barbara; Cruciani, Michel; Schwarz, Virginie; Nabe, Christian; Mayer, Joerg; Vogel, Wolfram; Abegg, Janosch; Lioret, Sonia; Avedissian, Franck; Cosse, Julien; Woodhouse, Stephen; Bradbury, Simon; Mollard, Matthieu; Solal, Lucie; Nodari, Antonio

    2015-01-01

    The French-German office for Renewable energies (OFAEnR) organised a conference on the support mechanisms evolution and the renewable energies integration in France and in Germany markets. In the framework of this French-German exchange of experience, participants exchanged views on the current support mechanisms in both countries and on their forthcoming legal modifications. The legal framework of direct renewable energy selling in the German market and the impacts and challenges of this model were addressed as well. Technical aspects of auction sales of electricity were approached too and illustrated with experience feedbacks from direct selling operators. This document brings together the available presentations (slides) made during this event: 1 - Tenders for Renewable energy and the German Energiewende - Perspectives, challenges, debates (Barbara Praetorius); 2 - Promotion of energy from renewable sources - A short analysis of the French public policy 2000 -2014 (Michel Cruciani); 3 - Support schemes for renewables in France and their evolution as foreseen in the energy transition law (Virginie Schwarz); 4 - Direct electricity selling on the wholesale market: legal framework and perspective - a French-German comparison (Christian Nabe); 5 - Self-consumption and power purchase Business framework in Germany (Joerg Mayer); 6 - Successful Integration of Renewable energies in the Market: the Role of the Power exchange (Wolfram Vogel); 7 - Earn money and do good by marketing renewables (Janosch Abegg); 8 - Proposals for a new electricity market design (Sonia Lioret)

  5. Global nuclear material monitoring with NDA and C/S data through integrated facility monitoring

    Howell, J.A.; Menlove, H.O.; Argo, P.; Goulding, C.; Klosterbuer, S.; Halbig, J.

    1996-01-01

    This paper focuses on a flexible, integrated demonstration of a monitoring approach for nuclear material monitoring. This includes aspects of item signature identification, perimeter portal monitoring, advanced data analysis, and communication as a part of an unattended continuous monitoring system in an operating nuclear facility. Advanced analysis is applied to the integrated nondestructive assay and containment and surveillance data that are synchronized in time. End result will be the foundation for a cost-effective monitoring system that could provide the necessary transparency even in areas that are denied to foreign nationals of both US and Russia should these processes and materials come under full-scope safeguards or bilateral agreements. Monitoring systems of this kind have the potential to provide additional benefits including improved nuclear facility security and safeguards and lower personnel radiation exposures. Demonstration facilities in this paper include VTRAP-prototype, Los Alamos Critical Assemblies Facility, Kazakhstan BM-350 Reactor monitor, DUPIC radiation monitoring, and JOYO and MONJU radiation monitoring

  6. [Integrated Management Area of Vascular Risk: A new organisational model for global control of risk factors].

    Armario, P; Jericó, C; Vila, L; Freixa, R; Martin-Castillejos, C; Rotllan, M

    Cardiovascular disease (CVD), is a major cause of morbidity and mortality that increases the cost of care. Currently there is a low degree of control of the main cardiovascular risk factors, although we have a good therapeutic arsenal. To achieve the improvement of this reality, a good coordination and multidisciplinary participation are essential. The development of new organizational models such as the Integrated Management Area of Vascular Risk can facilitate the therapeutic harmonization and unification of the health messages offered by different levels of care, based on clinical practice guidelines, in order to provide patient-centred integrated care. Copyright © 2016 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

  7. Global Principle of Ecological Integrity and its Implementation in Management of the Czech Landscape

    Cudlínová, Eva; Lapka, Miloslav; Líšková, Zuzana

    2005-01-01

    Roč. 24, č. 1 (2005), s. 89-107 ISSN 1335-342X R&D Projects: GA MŠk(CZ) ME 530; GA MŽP(CZ) SM/640/18/03 Grant - others:EU GOCE-CT-2003-505297-MULTAGRI Institutional research plan: CEZ:AV0Z60870520 Keywords : ecological integrity * landscape * typology * category Subject RIV: AO - Sociology, Demography Impact factor: 0.085, year: 2005

  8. The management of mechanical integrity inspections at small-sized 'Seveso' facilities

    Bragatto, Paolo A.; Pittiglio, Paolo; Ansaldi, Silvia

    2009-01-01

    The mechanical integrity (MI) of equipment has been controlled at all industrial facilities for many decades. Control methods and intervals are regulated by laws or codes and best practices. In European countries, the legislations implementing the Seveso Directives on the control of major accident hazards require the owner of establishments where hazardous chemicals are handled, to implement a safety management system (SMS). MI controls should be an integral part of the SMS. At large establishments this goal is achieved by adopting the RBI method, but in small-sized establishments with a limited budget and scanty personnel, a heuristic approach is more suitable. This paper demonstrates the feasibility and advantages of integrating SMS and MI by means of a simple method that includes a few basic concepts of RBI without additional costs for operator. This method, supported by a software tool, is resilient as it functions effectively in spite of eventual budget reductions and personnel turnover. The results of MI controls can also be exploited to monitor equipment condition and demonstrate the adequacy of technical systems to the Competent Authorities (CA). Furthermore, the SMS can 'capture' knowledge resulting from MI experience and exploit it for a better understanding of risk

  9. Neurocognitive mechanisms of perception-action coordination: a review and theoretical integration.

    Ridderinkhof, K Richard

    2014-10-01

    The present analysis aims at a theoretical integration of, and a systems-neuroscience perspective on, a variety of historical and contemporary views on perception-action coordination (PAC). We set out to determine the common principles or lawful linkages between sensory and motor systems that explain how perception is action-oriented and how action is perceptually guided. To this end, we analyze the key ingredients to such an integrated framework, examine the architecture of dual-system conjectures of PAC, and endeavor in an historical analysis of the key characteristics, mechanisms, and phenomena of PACs. This analysis will reveal that dual-systems views are in need of fundamental re-thinking, and its elements will be amalgamated with current views on action-oriented predictive processing into a novel integrative theoretical framework (IMPPACT: Impetus, Motivation, and Prediction in Perception-Action Coordination theory). From this framework and its neurocognitive architecture we derive a number of non-trivial predictions regarding conative, motive-driven PAC. We end by presenting a brief outlook on how IMPPACT might present novel insights into certain pathologies and into action expertise. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. A comparison of integrated river basin management strategies: A global perspective

    Zhao, Chunhong; Wang, Pei; Zhang, Guanghong

    In order to achieve the integrated river basin management in the arid and rapid developing region, the Heihe River Basin (HRB) in Northwestern China, one of critical river basins were selected as a representative example, while the Murray-Darling Basin (MDB) in Australia and the Colorado River Basin (CRB) in the USA were selected for comparative analysis in this paper. Firstly, the comparable characters and hydrological contexts of these three watersheds were introduced in this paper. Then, based on comparative studies on the river basin challenges in terms of the drought, intensive irrigation, and rapid industrialization, the hydrological background of the MDB, the CRB and the HRB was presented. Subsequently, the river management strategies were compared in three aspects: water allocation, water organizations, and water act and scientific projects. Finally, we proposed recommendations for integrated river basin management for the HRB: (1) Water allocation strategies should be based on laws and markets on the whole basin; (2) Public participation should be stressed by the channels between governance organizations and local communities; (3) Scientific research should be integrated into river management to understand the interactions between the human and nature.

  11. Mechanisms of spectral and temporal integration in the mustached bat inferior colliculus

    Wenstrup, Jeffrey James; Nataraj, Kiran; Sanchez, Jason Tait

    2012-01-01

    This review describes mechanisms and circuitry underlying combination-sensitive response properties in the auditory brainstem and midbrain. Combination-sensitive neurons, performing a type of auditory spectro-temporal integration, respond to specific, properly timed combinations of spectral elements in vocal signals and other acoustic stimuli. While these neurons are known to occur in the auditory forebrain of many vertebrate species, the work described here establishes their origin in the auditory brainstem and midbrain. Focusing on the mustached bat, we review several major findings: (1) Combination-sensitive responses involve facilitatory interactions, inhibitory interactions, or both when activated by distinct spectral elements in complex sounds. (2) Combination-sensitive responses are created in distinct stages: inhibition arises mainly in lateral lemniscal nuclei of the auditory brainstem, while facilitation arises in the inferior colliculus (IC) of the midbrain. (3) Spectral integration underlying combination-sensitive responses requires a low-frequency input tuned well below a neuron's characteristic frequency (ChF). Low-ChF neurons in the auditory brainstem project to high-ChF regions in brainstem or IC to create combination sensitivity. (4) At their sites of origin, both facilitatory and inhibitory combination-sensitive interactions depend on glycinergic inputs and are eliminated by glycine receptor blockade. Surprisingly, facilitatory interactions in IC depend almost exclusively on glycinergic inputs and are largely independent of glutamatergic and GABAergic inputs. (5) The medial nucleus of the trapezoid body (MNTB), the lateral lemniscal nuclei, and the IC play critical roles in creating combination-sensitive responses. We propose that these mechanisms, based on work in the mustached bat, apply to a broad range of mammals and other vertebrates that depend on temporally sensitive integration of information across the audible spectrum. PMID:23109917

  12. The dynamical integrity concept for interpreting/ predicting experimental behaviour: from macro- to nano-mechanics.

    Lenci, Stefano; Rega, Giuseppe; Ruzziconi, Laura

    2013-06-28

    The dynamical integrity, a new concept proposed by J.M.T. Thompson, and developed by the authors, is used to interpret experimental results. After reviewing the main issues involved in this analysis, including the proposal of a new integrity measure able to capture in an easy way the safe part of basins, attention is dedicated to two experiments, a rotating pendulum and a micro-electro-mechanical system, where the theoretical predictions are not fulfilled. These mechanical systems, the former at the macro-scale and the latter at the micro-scale, permit a comparative analysis of different mechanical and dynamical behaviours. The fact that in both cases the dynamical integrity permits one to justify the difference between experimental and theoretical results, which is the main achievement of this paper, shows the effectiveness of this new approach and suggests its use in practical situations. The men of experiment are like the ant, they only collect and use; the reasoners resemble spiders, who make cobwebs out of their own substance. But the bee takes the middle course: it gathers its material from the flowers of the garden and field, but transforms and digests it by a power of its own. Not unlike this is the true business of philosophy (science); for it neither relies solely or chiefly on the powers of the mind, nor does it take the matter which it gathers from natural history and mechanical experiments and lay up in the memory whole, as it finds it, but lays it up in the understanding altered and digested. Therefore, from a closer and purer league between these two faculties, the experimental and the rational (such as has never been made), much may be hoped. (Francis Bacon 1561-1626) But are we sure of our observational facts? Scientific men are rather fond of saying pontifically that one ought to be quite sure of one's observational facts before embarking on theory. Fortunately those who give this advice do not practice what they preach. Observation and theory get

  13. Global climate regulation and border adjustment mechanisms: the case of carbon importers inclusion in the european trading scheme

    2008-06-01

    The creation of an inclusion mechanism applied to imports whose production process increases significantly the global climate risk is looked upon as a solution to a collective-action problem. Such a mechanism would provide those States that will sign the next United Nations Convention on Climate Change with a potential remedy if and when gaps between quantified objects, to which all are committed, entail significant competition distortions. Whether this mechanism assumes the form of an external carbon tax or consists in including importers in the European system of CO 2 quota exchanges, it would surely respond to the re-distributive need generated by global warming, provided that the proceeds are used to help bring industrial production in developing countries up to standard. These restrictive measures aimed at preserving the planet are probably compatible with the extraordinary regimes applied by the WTO, which already uses exogenous non-trade norms to arbitrate conflicts. This would validate further the legitimacy of authority transfers onto the WTO, whose scope of legal authority increases constantly, along with that of conflicts that stem from collective preferences. (author)

  14. Integrated assessment of global water scarcity over the 21st century under multiple climate change mitigation policies

    Hejazi, Mohamad I.; Edmonds, James A.; Clarke, Leon E.; Kyle, G. Page; Davies, Evan; Chaturvedi, Vaibhav; Wise, Marshall A.; Patel, Pralit L.; Eom, Jiyong; Calvin, Katherine V.

    2014-08-01

    Water scarcity conditions over the 21st century both globally and regionally are assessed in the context of climate change and climate mitigation policies, by estimating both water availability and water demand within the Global Change Assessment Model (GCAM), a leading community integrated assessment model of energy, agriculture, climate, and water. To quantify changes in future water availability, a new gridded water-balance global hydrologic model – namely, the Global Water Availability Model (GWAM) – is developed and evaluated. Global water demands for six major demand sectors (irrigation, livestock, domestic, electricity generation, primary energy production, and manufacturing) are modeled in GCAM at the regional scale (14 geopolitical regions, 151 sub-regions) and then spatially downscaled to 0.5 o x 0.5o resolution to match the scale of GWAM. Using a baseline scenario (i.e., no climate change mitigation policy) with radiative forcing reaching 8.8 W/m2 (equivalent to the SRES A1Fi emission scenario) and three climate policy scenarios with increasing mitigation stringency of 7.7, 5.5, and 4.2 W/m2 (equivalent to the SRES A2, B2, and B1 emission scenarios, respectively), we investigate the effects of emission mitigation policies on water scarcity. Two carbon tax regimes (a universal carbon tax (UCT) which includes land use change emissions, and a fossil fuel and industrial emissions carbon tax (FFICT) which excludes land use change emissions) are analyzed. The baseline scenario results in more than half of the world population living under extreme water scarcity by the end of the 21st century. Additionally, in years 2050 and 2095, 36% (28%) and 44% (39%) of the global population, respectively, is projected to live in grid cells (in basins) that will experience greater water demands than the amount of available water in a year (i.e., the water scarcity index (WSI) > 1.0). When comparing the climate policy scenarios to the baseline scenario while maintaining

  15. A Comparative Study on Recently-Introduced Nature-Based Global Optimization Methods in Complex Mechanical System Design

    Abdulbaset El Hadi Saad

    2017-10-01

    Full Text Available Advanced global optimization algorithms have been continuously introduced and improved to solve various complex design optimization problems for which the objective and constraint functions can only be evaluated through computation intensive numerical analyses or simulations with a large number of design variables. The often implicit, multimodal, and ill-shaped objective and constraint functions in high-dimensional and “black-box” forms demand the search to be carried out using low number of function evaluations with high search efficiency and good robustness. This work investigates the performance of six recently introduced, nature-inspired global optimization methods: Artificial Bee Colony (ABC, Firefly Algorithm (FFA, Cuckoo Search (CS, Bat Algorithm (BA, Flower Pollination Algorithm (FPA and Grey Wolf Optimizer (GWO. These approaches are compared in terms of search efficiency and robustness in solving a set of representative benchmark problems in smooth-unimodal, non-smooth unimodal, smooth multimodal, and non-smooth multimodal function forms. In addition, four classic engineering optimization examples and a real-life complex mechanical system design optimization problem, floating offshore wind turbines design optimization, are used as additional test cases representing computationally-expensive black-box global optimization problems. Results from this comparative study show that the ability of these global optimization methods to obtain a good solution diminishes as the dimension of the problem, or number of design variables increases. Although none of these methods is universally capable, the study finds that GWO and ABC are more efficient on average than the other four in obtaining high quality solutions efficiently and consistently, solving 86% and 80% of the tested benchmark problems, respectively. The research contributes to future improvements of global optimization methods.

  16. Governance Mechanism for Global Greenhouse Gas Emissions: A Stochastic Differential Game Approach

    Wei Yu

    2013-01-01

    Full Text Available Today developed and developing countries have to admit the fact that global warming is affecting the earth, but the fundamental problem of how to divide up necessary greenhouse gas reductions between developed and developing countries remains. In this paper, we propose cooperative and noncooperative stochastic differential game models to describe greenhouse gas emissions decision makings of developed and developing countries, calculate their feedback Nash equilibrium and the Pareto optimal solution, characterize parameter spaces that developed and developing countries can cooperate, design cooperative conditions under which participants buy the cooperative payoff, and distribute the cooperative payoff with Nash bargaining solution. Lastly, numerical simulations are employed to illustrate the above results.

  17. Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats

    Nobre, Maria Elizabeth Pereira; Correia, Alyne Oliveira; Mendon?a, Francisco Nilson Maciel; Uchoa, Luiz Ricardo Ara?jo; Vasconcelos, Jessica Tamara Nunes; de Ara?jo, Carlos Ney Alencar; Brito, Gerly Anne de Castro; Siqueira, Rafaelly Maria Pinheiro; Cerqueira, Gilberto dos Santos; Neves, Kelly Rose Tavares; Arida, Ricardo M?rio; Viana, Glauce Socorro de Barros

    2016-01-01

    Background. Omega-3 (ω3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of ω3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with ω3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic animals were orally treated with 1% cremophor and, 1 h after the last administrati...

  18. Emergence of long distance bird migrations: a new model integrating global climate changes

    Louchart, Antoine

    2008-12-01

    During modern birds history, climatic and environmental conditions have evolved on wide scales. In a continuously changing world, landbirds annual migrations emerged and developed. However, models accounting for the origins of these avian migrations were formulated with static ecogeographic perspectives. Here I reviewed Cenozoic paleoclimatic and paleontological data relative to the palearctic paleotropical long distance (LD) migration system. This led to propose a new model for the origin of LD migrations, the ‘shifting home’ model (SHM). It is based on a dynamic perspective of climate evolution and may apply to the origins of most modern migrations. Non-migrant tropical African bird taxa were present at European latitudes during most of the Cenozoic. Their distribution limits shifted progressively toward modern tropical latitudes during periods of global cooling and increasing seasonality. In parallel, decreasing winter temperatures in the western Palearctic drove shifts of population winter ranges toward the equator. I propose that this induced the emergence of most short distance migrations, and in turn LD migrations. This model reconciliates ecologically tropical ancestry of most LD migrants with predominant winter range shifts, in accordance with requirements for heritable homing. In addition, it is more parsimonious than other non-exclusive models. Greater intrinsic plasticity of winter ranges implied by the SHM is supported by recently observed impacts of the present global warming on migrating birds. This may induce particular threats to some LD migrants. The ancestral, breeding homes of LD migrants were not ‘northern’ or ‘southern’ but shifted across high and middle latitudes while migrations emerged through winter range shifts themselves.

  19. Mechanisms Controlling Global Mean Sea Surface Temperature Determined From a State Estimate

    Ponte, R. M.; Piecuch, C. G.

    2018-04-01

    Global mean sea surface temperature (T¯) is a variable of primary interest in studies of climate variability and change. The temporal evolution of T¯ can be influenced by surface heat fluxes (F¯) and by diffusion (D¯) and advection (A¯) processes internal to the ocean, but quantifying the contribution of these different factors from data alone is prone to substantial uncertainties. Here we derive a closed T¯ budget for the period 1993-2015 based on a global ocean state estimate, which is an exact solution of a general circulation model constrained to most extant ocean observations through advanced optimization methods. The estimated average temperature of the top (10-m thick) level in the model, taken to represent T¯, shows relatively small variability at most time scales compared to F¯, D¯, or A¯, reflecting the tendency for largely balancing effects from all the latter terms. The seasonal cycle in T¯ is mostly determined by small imbalances between F¯ and D¯, with negligible contributions from A¯. While D¯ seems to simply damp F¯ at the annual period, a different dynamical role for D¯ at semiannual period is suggested by it being larger than F¯. At periods longer than annual, A¯ contributes importantly to T¯ variability, pointing to the direct influence of the variable ocean circulation on T¯ and mean surface climate.

  20. Mechanical Integrity of Flexible In-Zn-Sn-O Film for Flexible Transparent Electrode

    Kim, Young Sung; Oh, Se-In; Choa, Sung-Hoon

    2013-05-01

    The mechanical integrity of transparent In-Zn-Sn-O (IZTO) films is investigated using outer/inner bending, stretching, and twisting tests. Amorphous IZTO films are grown using a pulsed DC magnetron sputtering system with an IZTO target on a polyimide substrate at room temperature. Changes in the optical and electrical properties of IZTO films depend on the oxygen partial pressure applied during the film deposition process. In the case of 3% oxygen partial pressure, the IZTO films exhibit s resistivity of 8.3×10-4 Ω cm and an optical transmittance of 86%. The outer bending test shows that the critical bending radius decreases from 10 to 7.5 mm when the oxygen partial pressure is increased from 1 to 3%. The inner bending test reveals that the critical bending radius of all IZTO films is 3.5 mm regardless of oxygen partial pressure. The IZTO films also show excellent mechanical reliability in the bending fatigue tests of more than 10,000 cycles. In the uniaxial stretching tests, the electrical resistance of the IZTO film does not change until a strain of 2.4% is reached. The twisting tests demonstrate that the electrical resistance of IZTO films remains unchanged up to 25°. These results suggest that IZTO films have excellent mechanical durability and flexibility in comparison with already reported crystallized indium tin oxide (ITO) films.

  1. Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies.

    Hongwei Chu

    Full Text Available Epilepsy is a complex neurological disorder and a significant health problem. The pathogenesis of epilepsy remains obscure in a significant number of patients and the current treatment options are not adequate in about a third of individuals which were known as refractory epilepsies (RE. Network medicine provides an effective approach for studying the molecular mechanisms underlying complex diseases. Here we integrated 1876 disease-gene associations of RE and located those genes to human protein-protein interaction (PPI network to obtain 42 significant RE-associated disease modules. The functional analysis of these disease modules showed novel molecular pathological mechanisms of RE, such as the novel enriched pathways (e.g., "presynaptic nicotinic acetylcholine receptors", "signaling by insulin receptor". Further analysis on the relationships between current drug targets and the RE-related disease genes showed the rational mechanisms of most antiepileptic drugs. In addition, we detected ten potential novel drug targets (e.g., KCNA1, KCNA4-6, KCNC3, KCND2, KCNMA1, CAMK2G, CACNB4 and GRM1 located in three RE related disease modules, which might provide novel insights into the new drug discovery for RE therapy.

  2. Global sensitivity analysis of thermo-mechanical models in numerical weld modelling; Analyse de sensibilite globale de modeles thermomecaniques de simulation numerique du soudage

    Petelet, M

    2007-10-15

    Current approach of most welding modellers is to content themselves with available material data, and to chose a mechanical model that seems to be appropriate. Among inputs, those controlling the material properties are one of the key problems of welding simulation: material data are never characterized over a sufficiently wide temperature range {exclamation_point} This way to proceed neglect the influence of the uncertainty of input data on the result given by the computer code. In this case, how to assess the credibility of prediction? This thesis represents a step in the direction of implementing an innovative approach in welding simulation in order to bring answers to this question, with an illustration on some concretes welding cases. The global sensitivity analysis is chosen to determine which material properties are the most sensitive in a numerical welding simulation and in which range of temperature. Using this methodology require some developments to sample and explore the input space covering welding of different steel materials. Finally, input data have been divided in two groups according to their influence on the output of the model (residual stress or distortion). In this work, complete methodology of the global sensitivity analysis has been successfully applied to welding simulation and lead to reduce the input space to the only important variables. Sensitivity analysis has provided answers to what can be considered as one of the probable frequently asked questions regarding welding simulation: for a given material which properties must be measured with a good accuracy and which ones can be simply extrapolated or taken from a similar material? (author)

  3. An Assessment Tool to Integrate Sustainability Principles into the Global Supply Chain

    María Jesús Muñoz-Torres

    2018-02-01

    Full Text Available The integration of sustainability principles into the assessment of companies along the supply chains is a growing research area. However, there is an absence of a generally accepted method to evaluate corporate sustainability performance (CSP, and the models and frameworks proposed by the literature present various important challenges to be addressed. A systematic literature review on the supply chain at the corporate level has been conducted, analyzing the main strengths and gaps in the sustainability assessment literature. Therefore, this paper aims to contribute to the development of this field by proposing an assessment framework a leading company can adopt to expand sustainability principles to the rest of the members of the supply chain. This proposal is based on best practices and integrates and shares efforts with key initiatives (for instance, the Organizational Environmental Footprint from the European Commission and United Nations Environment Programme and the Society of Environmental Toxicology and Chemistry UNEP/SETAC; moreover, it overcomes important limitations of the current sustainability tools in a supply chain context consistent with the circular economy, the Sustainable Development Goals (SDGs, planetary boundaries, and social foundation requirements. The results obtained create, on the one hand, new opportunities for academics; and, on the other hand, in further research, the use of this framework could be a means of actively engaging companies in their supply chains and of achieving the implementation of practical and comprehensive CSP assessment.

  4. Integrated Strategic Planning of Global Production Networks and Financial Hedging under Uncertain Demands and Exchange Rates

    Achim Koberstein

    2013-11-01

    Full Text Available In this paper, we present a multi-stage stochastic programming model that integrates financial hedging decisions into the planning of strategic production networks under uncertain exchange rates and product demands. This model considers the expenses of production plants and the revenues of markets in different currency areas. Financial portfolio planning decisions for two types of financial instruments, forward contracts and options, are represented explicitly by multi-period decision variables and a multi-stage scenario tree. Using an illustrative example, we analyze the impact of exchange-rate and demand volatility, the level of investment expenses and interest rate spreads on capacity location and dimensioning decisions. In particular, we show that, in the illustrative example, the exchange-rate uncertainty cannot be completely eliminated by financial hedging in the presence of demand uncertainty. In this situation, we find that the integrated model can result in better strategic planning decisions for a risk-averse decision maker compared to traditional modeling approaches.

  5. Overview of past, ongoing and future efforts of the integrated modeling of global change for Northern Eurasia

    Monier, Erwan; Kicklighter, David; Sokolov, Andrei; Zhuang, Qianlai; Melillo, Jerry; Reilly, John

    2016-04-01

    Northern Eurasia is both a major player in the global carbon budget (it includes roughly 70% of the Earth's boreal forest and more than two-thirds of the Earth's permafrost) and a region that has experienced dramatic climate change (increase in temperature, growing season length, floods and droughts) over the past century. Northern Eurasia has also undergone significant land-use change, both driven by human activity (including deforestation, expansion of agricultural lands and urbanization) and natural disturbances (such as wildfires and insect outbreaks). These large environmental and socioeconomic impacts have major implications for the carbon cycle in the region. Northern Eurasia is made up of a diverse set of ecosystems that range from tundra to forests, with significant areas of croplands and pastures as well as deserts, with major urban areas. As such, it represents a complex system with substantial challenges for the modeling community. In this presentation, we provide an overview of past, ongoing and possible future efforts of the integrated modeling of global change for Northern Eurasia. We review the variety of existing modeling approaches to investigate specific components of Earth system dynamics in the region. While there are a limited number of studies that try to integrate various aspects of the Earth system (through scale, teleconnections or processes), we point out that there are few systematic analyses of the various feedbacks within the Earth system (between components, regions or scale). As a result, there is a lack of knowledge of the relative importance of such feedbacks, and it is unclear how policy relevant current studies are that fail to account for these feedbacks. We review the role of Earth system models, and their advantages/limitations compared to detailed single component models. We further introduce the human activity system (global trade, economic models, demographic model and so on), the need for coupled human/earth system models

  6. Guarantee of remaining life time. Integrity of mechanical components and control of ageing phenomena

    Schuler, X.; Herter, K.H.; Koenig, G.

    2012-01-01

    The life time of safety relevant systems, structures and components (SSC) of Nuclear Power Plants (NPP) is determined by two main principles. First of all the required quality has to be produced during the design and fabrication process. This means that quality has to be produced and can't be improved by excessive inspections (Basis Safety - quality through production principle). The second one is assigned to the initial quality which has to be maintained during operation. This concerns safe operation during the total life time (life time management), safety against ageing phenomena (AM - ageing management) as well as proof of integrity (e.g. break preclusion or avoidance of fracture for SSC with high safety relevance). Initiated by the Fukushima Dai-ichi event in Japan in spring 2011 for German NPP's Long Term Operation (LTO) is out of question. In June 2011 legislation took decision to phase-out from nuclear by 2022. As a fact safe operation shall be guaranteed for the remaining life time. Within this technical framework the ageing management is a key element. Depending on the safety-relevance of the SSC under observation including preventive maintenance various tasks are required in particular to clarify the mechanisms which contribute systemspecifically to the damage of the components and systems and to define their controlling parameters which have to be monitored and checked. Appropriate continuous or discontinuous measures are to be considered in this connection. The approach to ensure a high standard of quality in operation for the remaining life time and the management of the technical and organizational aspects are demonstrated and explained. The basis for ageing management to be applied to NNPs is included in Nuclear Safety Standard 1403 which describes the ageing management procedures. For SSC with high safety relevance a verification analysis for rupture preclusion (proof of integrity, integrity concept) shall be performed (Nuclear Safety Standard 3206

  7. Mechanical dispersion and global longitudinal strain by speckle tracking echocardiography: Predictors of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy.

    Candan, Ozkan; Gecmen, Cetin; Bayam, Emrah; Guner, Ahmet; Celik, Mehmet; Doğan, Cem

    2017-06-01

    In this study, we investigated whether mechanical dispersion which reflects electrical abnormality and other echocardiographic and clinic parameters predict appropriate ICD shock in patients undergone ICD implantation for hypertrophic cardiomyopathy. Sixty-three patients who received ICD implantation for primary or secondary prevention were included in the study. Patients' clinical, electrocardiographic, 2D classic, and speckle tracking echocardiographic data were collected. Mechanical dispersion was defined as the standard deviation of time to peak negative strain in 18 left ventricular segments. Appropriate ICD therapy was defined as cardioversion or defibrillation due to ventricular tachycardia or fibrillation. Patients were divided into two groups as occurrence or the absence of appropriate ICD therapy. A total of 17 (26.9%) patients were observed to have an appropriate ICD therapy during follow-up periods. In patients who performed appropriate ICD therapy, a larger left atrial volume index, higher sudden cardiac death (SCD)-Risk Score, longer mechanical dispersion, and decreased global longitudinal peak strain (GLPS) were observed. In multivariate logistic regression analysis, including (GLPS, mechanical dispersion, LAVi, and SCD-Risk Score) was used to determine independent predictors of occurrence of appropriate ICD therapy during the follow-up. Mechanical dispersion, GLPS, and SCD-Risk Score were found to be independent predictors of occurrence of appropriate ICD therapy. Mechanical dispersion, GLPS, and SCD-Risk Score were found to be predictive for appropriate ICD therapy in patients receiving ICD implantation. Readily measurable mechanical dispersion and GLPS could be helpful to distinguish patients at high risk who could optimally benefit from ICD therapy. © 2017, Wiley Periodicals, Inc.

  8. Derivation of the Schrodinger Equation from the Hamilton-Jacobi Equation in Feynman's Path Integral Formulation of Quantum Mechanics

    Field, J. H.

    2011-01-01

    It is shown how the time-dependent Schrodinger equation may be simply derived from the dynamical postulate of Feynman's path integral formulation of quantum mechanics and the Hamilton-Jacobi equation of classical mechanics. Schrodinger's own published derivations of quantum wave equations, the first of which was also based on the Hamilton-Jacobi…

  9. Solvability of a class of systems of infinite-dimensional integral equations and their application in statistical mechanics

    Gonchar, N.S.

    1986-01-01

    This paper presents a mathematical method developed for investigating a class of systems of infinite-dimensional integral equations which have application in statistical mechanics. Necessary and sufficient conditions are obtained for the uniqueness and bifurcation of the solution of this class of systems of equations. Problems of equilibrium statistical mechanics are considered on the basis of this method

  10. Mechanisms of Formation of Secondary Organic Aerosols and Implications for Global Radiative Forcing

    Seinfeld, John H. [California Inst. of Technology (CalTech), Pasadena, CA (United States)

    2011-12-02

    Organic material constitutes about 50% of global atmospheric aerosol mass, and the dominant source of organic aerosol is the oxidation of volatile hydrocarbons, to produce secondary organic aerosol (SOA). Understanding the formation of SOA is crucial to predicting present and future climate effects of atmospheric aerosols. The goal of this program is to significantly increase our understanding of secondary organic aerosol (SOA) formation in the atmosphere. Ambient measurements indicate that the amount of SOA in the atmosphere exceeds that predicted in current models based on existing laboratory chamber data. This would suggest that either the SOA yields measured in laboratory chambers are understated or that all major organic precursors have not been identified. In this research program we are systematically exploring these possibilities.

  11. Reduction and Uncertainty Analysis of Chemical Mechanisms Based on Local and Global Sensitivities

    Esposito, Gaetano

    Numerical simulations of critical reacting flow phenomena in hypersonic propulsion devices require accurate representation of finite-rate chemical kinetics. The chemical kinetic models available for hydrocarbon fuel combustion are rather large, involving hundreds of species and thousands of reactions. As a consequence, they cannot be used in multi-dimensional computational fluid dynamic calculations in the foreseeable future due to the prohibitive computational cost. In addition to the computational difficulties, it is also known that some fundamental chemical kinetic parameters of detailed models have significant level of uncertainty due to limited experimental data available and to poor understanding of interactions among kinetic parameters. In the present investigation, local and global sensitivity analysis techniques are employed to develop a systematic approach of reducing and analyzing detailed chemical kinetic models. Unlike previous studies in which skeletal model reduction was based on the separate analysis of simple cases, in this work a novel strategy based on Principal Component Analysis of local sensitivity values is presented. This new approach is capable of simultaneously taking into account all the relevant canonical combustion configurations over different composition, temperature and pressure conditions. Moreover, the procedure developed in this work represents the first documented inclusion of non-premixed extinction phenomena, which is of great relevance in hypersonic combustors, in an automated reduction algorithm. The application of the skeletal reduction to a detailed kinetic model consisting of 111 species in 784 reactions is demonstrated. The resulting reduced skeletal model of 37--38 species showed that the global ignition/propagation/extinction phenomena of ethylene-air mixtures can be predicted within an accuracy of 2% of the full detailed model. The problems of both understanding non-linear interactions between kinetic parameters and

  12. [New theory of holistic integrative physiology and medicine. I: New insight of mechanism of control and regulation of breathing].

    Sun, Xing-guo

    2015-07-01

    The modern systemic physiology, based on limit-understand functional classification, has significant limitation and one-sidedness. Human being is organic; we should approach the mechanism of control and regulation of breathing integrating all the systems. We use new theory of holistic integrative physiology and medicine to explain the mechanism of control and regulation of breathing. Except the mean level information, the up-down "W" waveform information of arterial blood gas (ABG) is core signal to control and regulate breathing. In order to do so, we must integrate all systems together. New theory will help to explain some unanswered questions in physiology and medicine, for example: fetal does not breathing; how first breath generate; how respiratory rhythm and frequency generate, etc. Breathing is the sign of life. Mechanism of control and regulation of breathing has to integrate respiration, circulation, nerves, metabolism, exercise, sleep and digestion, absorption and elimination and etc altogether.

  13. Global Mechanical Response and Its Relation to Deformation and Failure Modes at Various Length Scales Under Shock Impact in Alumina AD995 Armor Ceramic

    Dandekar, D. P; McCauley, J. W; Green, W. H; Bourne, N. K; Chen, M. W

    2008-01-01

    ... maps relating the experimentally measured global mechanical response of a material through matured shock wave diagnostics to the nature of concurrent deformation and damage generated at varying length scales under shock wave loading.

  14. Against Globalization

    Philipsen, Lotte; Baggesgaard, Mads Anders

    2013-01-01

    In order to understand globalization, we need to consider what globalization is not. That is, in order to understand the mechanisms and elements that work toward globalization, we must, in a sense, read against globalization, highlighting the limitations of the concept and its inherent conflicts....... Only by employing this as a critical practice will we be analytically able to gain a dynamic understanding of the forces of globalization as they unfold today and as they have developed historically....

  15. The Educated Citizen and Global Public-Health Issues: One Model for Integration into the Undergraduate Curriculum.

    Caron, Rosemary M

    2016-01-01

    The Educated Citizen Initiative proposes that an understanding of public-health issues is a core component of an educated citizenry and is essential to develop one's societal responsibility. This initiative supports the Institute of Medicine's recommendation that "all undergraduates should have access to education in public health." Furthermore, the Liberal Education and America's Promise (LEAP) framework developed by the Association of American Colleges and Universities supports the "integration of public-health education into general and liberal education with an aim to produce an educated citizenry." The LEAP framework is implemented by teaching about the role of social determinants in a population's health status; the significance of personal and social responsibility; and providing skills for inquiry, critical thinking, problem solving, and evaluation. This article describes one university's experience in generating an educated citizenry cognizant of comprehensive public-health conflicts, thus contributing to both a local and global perspective on learning.

  16. Insulated Concrete Form Walls Integrated With Mechanical Systems in a Cold Climate Test House

    Mallay, D. [Home Innovation Research Labs, Upper Marlboro, MD (United States); Wiehagen, J. [Home Innovation Research Labs, Upper Marlboro, MD (United States)

    2014-09-01

    Transitioning from standard light frame to a thermal mass wall system in a high performance home will require a higher level of design integration with the mechanical systems. The much higher mass in the ICF wall influences heat transfer through the wall and affects how the heating and cooling system responds to changing outdoor conditions. This is even more important for efficient, low-load homes with efficient heat pump systems in colder climates where the heating and cooling peak loads are significantly different from standard construction. This report analyzes a range of design features and component performance estimates in an effort to select practical, cost-effective solutions for high performance homes in a cold climate.

  17. Time travel paradoxes, path integrals, and the many worlds interpretation of quantum mechanics

    Everett, Allen

    2004-01-01

    We consider two approaches to evading paradoxes in quantum mechanics with closed timelike curves. In a model similar to Politzer's, assuming pure states and using path integrals, we show that the problems of paradoxes and of unitarity violation are related; preserving unitarity avoids paradoxes by modifying the time evolution so that improbable events become certain. Deutsch has argued, using the density matrix, that paradoxes do not occur in the 'many worlds interpretation'. We find that in this approach account must be taken of the resolution time of the device that detects objects emerging from a wormhole or other time machine. When this is done one finds that this approach is viable only if macroscopic objects traversing a wormhole interact with it so strongly that they are broken into microscopic fragments

  18. Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting.

    Ong, Chin Siang; Fukunishi, Takuma; Nashed, Andrew; Blazeski, Adriana; Zhang, Huaitao; Hardy, Samantha; DiSilvestre, Deborah; Vricella, Luca; Conte, John; Tung, Leslie; Tomaselli, Gordon; Hibino, Narutoshi

    2017-07-02

    This protocol describes 3D bioprinting of cardiac tissue without the use of biomaterials, using only cells. Cardiomyocytes, endothelial cells and fibroblasts are first isolated, counted and mixed at desired cell ratios. They are co-cultured in individual wells in ultra-low attachment 96-well plates. Within 3 days, beating spheroids form. These spheroids are then picked up by a nozzle using vacuum suction and assembled on a needle array using a 3D bioprinter. The spheroids are then allowed to fuse on the needle array. Three days after 3D bioprinting, the spheroids are removed as an intact patch, which is already spontaneously beating. 3D bioprinted cardiac patches exhibit mechanical integration of component spheroids and are highly promising in cardiac tissue regeneration and as 3D models of heart disease.

  19. Evaluation of mechanical integrity for helical coil hold-down spring of PLUS7TM fuel

    Choi, Ki Sung; Kim, Yong Hwan; Kwon, Jung Tack; Kim, Kyu Tae

    2004-01-01

    Nuclear fuel assembly is subject to hydraulic forces generated by primary coolant flow during reactor operation. These forces may be sufficient to overcome the fuel assembly weight thereby allowing the fuel assembly to lift off of its support. To provide a positive hold-down margin against the upward coolant flow forces, helical coil springs or leaf springs are installed in the fuel assemblies. An advanced fuel for Korean Standard Nuclear Power Plants (KSNP), PLUS7 fuel has developed to get the thermal margin increase, failure free and high seismic resistance, etc. And the new designed helical coil hold-down spring was introduced into PLUS7 fuel assembly. The purpose of this paper is to evaluate the mechanical integrity for the helical coil hold-down spring of PLUS7 fuel assembly

  20. Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms

    Saeed S. Banawas

    2018-01-01

    Full Text Available Clostridium difficile (C. difficile is the most prevalent causative pathogen of healthcare-associated diarrhea. Notably, over the past 10 years, the number of Clostridium difficile outbreaks has increased with the rate of morbidity and mortality. The occurrence and spread of C. difficile strains that are resistant to multiple antimicrobial drugs complicate prevention as well as potential treatment options. Most C. difficile isolates are still susceptible to metronidazole and vancomycin. Incidences of C. difficile resistance to other antimicrobial drugs have also been reported. Most of the antibiotics correlated with C. difficile infection (CDI, such as ampicillin, amoxicillin, cephalosporins, clindamycin, and fluoroquinolones, continue to be associated with the highest risk for CDI. Still, the detailed mechanism of resistance to metronidazole or vancomycin is not clear. Alternation in the target sites of the antibiotics is the main mechanism of erythromycin, fluoroquinolone, and rifamycin resistance in C. difficile. In this review, different antimicrobial agents are discussed and C. difficile resistance patterns and their mechanism of survival are summarized.