WorldWideScience

Sample records for genetics meeting rotterdam

  1. Genetic technologies meet the public

    DEFF Research Database (Denmark)

    Lassen, Jesper; Jamison, Andrew

    2006-01-01

    To clarify concerns that the public has with genetic technologies, the article presents the results of focus group interviews conducted in Denmark in 2000. The concerns of the public are divided into three ideal-typical categories: social (dealing with environmental and health risks), economic (d...

  2. Radicalisering moslimjongeren in Rotterdam?

    Directory of Open Access Journals (Sweden)

    Ton Notten

    2011-05-01

    Inlichtingen- en veiligheidsdiensten houden radicaliseringtendensen binnen de islamitische gemeenschappen scherp in de gaten. Het zijn vooral moslimjongeren die, volgens openbare verslagen van de Algemene Inlichtingen- en Veiligheidsdienst (AIVD, de Nationaal Coördinator Terrorismebestrijding (NCTb en het Informatie SchakelPunt Radicalisering (ISPR, ontvankelijk zijn voor radicale ideeën. Bij de juistheid en nauwkeurigheid van die rapportages plaatsen wij vraagtekens. Van radicalisering blijkt bijvoorbeeld in Rotterdam vrijwel geen sprake te zijn. Voor zover de problemen iets van doen hebben met radicalisering, lijken ze meer te liggen op het gebied van samenleven en opvoeding: de culturele en normatieve tegenstellingen tussen bevolkingsgroepen – moslims en niet-moslims – nemen toe. Polarisatie is het eigenlijke probleem en niet radicalisering. Wij stellen het diffuse begrip ‘radicalisering’ ter discussie zoals dat een belangrijke rol speelt in de veiligheidsrisicodebatten, bij wetenschappelijk onderzoek en binnen de kring van inlichtingen- en veiligheidsdiensten. Ter illustratie gaan we nader in op de feitelijke ontwikkelingen in Rotterdam. Op grond van onze verkenning bepleiten we andere vormen en aandachtsvelden in het onderzoek naar radicalisering.

  3. Rotterdam Navel Gazing as Success Factor… (case)

    NARCIS (Netherlands)

    G.J. Van der Star; dr. A. Maas

    2016-01-01

    Case about Henk, sector manager Cleantech at Rotterdam Partners. His responsibility is to stimulate the Circular Economy of Rotterdam, this in cooperation with the “government” of Rotterdam. Of course he knows a lot about what a Circular Economy theoretically is and should be, but to put in the day

  4. Rotterdam Navel Gazing as Success Factor… (case)

    NARCIS (Netherlands)

    Star, G.J. Van der; Maas, A.

    2016-01-01

    Case about Henk, sector manager Cleantech at Rotterdam Partners. His responsibility is to stimulate the Circular Economy of Rotterdam, this in cooperation with the “government” of Rotterdam. Of course he knows a lot about what a Circular Economy theoretically is and should be, but to put in the day

  5. Shuttlehalte Noordrand Rotterdam: Analyse vervoerkundige haalbaarheid

    NARCIS (Netherlands)

    Lutje Schipholt, L.R.; Egeter, B.; Van Goeverden, C.D.; Schoemaker, T.J.H.

    1994-01-01

    Rapport in opdracht van Projectbureau Noordrand Rotterdam. In dit rapport is de vervoerkundige haalbaarheid onderzocht van een shuttlehalte in de Noordrand van Rotterdam aan de mogelijk nieuw aan te leggen HSL tussen Rotterdam en Schiphol onderzocht. Geconcludeerd kan worden dat een halte voor de b

  6. The cultural strategy of Rotterdam

    Directory of Open Access Journals (Sweden)

    Jan Buursink

    1999-05-01

    Full Text Available This paper deals with the cultural policy and strategy of Rotterdam, in particular with regard to its designation as 'European City of Culture' for the year 2001. Having been a port and manufacturing city for many years, with a large proportion of lowly educated people, the city's first goal has been for many years to ameliorate the cultural climate of the city to the benefit of its residents. Since 1987, however, this cultural policy more and more received a market-oriented emphasis. The eternal rivalry with Amsterdam, the absolute cultural capital of the country, and the expectation that a cultural image would enhance the attractiveness of the city for economic investments, are the main factors in this reorientation. Rotterdam's prospects in the market of international urban tourism are, however, weak, because this city does not possess an attractive historical core. Therefore, modern architecture has become the trademark of Rotterdam.

  7. A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies.

    Science.gov (United States)

    Brautbar, Ariel; Pompeii, Lisa A; Dehghan, Abbas; Ngwa, Julius S; Nambi, Vijay; Virani, Salim S; Rivadeneira, Fernando; Uitterlinden, André G; Hofman, Albert; Witteman, Jacqueline C M; Pencina, Michael J; Folsom, Aaron R; Cupples, L Adrienne; Ballantyne, Christie M; Boerwinkle, Eric

    2012-08-01

    Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associated with coronary heart disease (CHD). We examined whether SNPs selected based on predefined criteria will improve CHD risk prediction when added to traditional risk factors (TRFs). SNPs were selected from the literature based on association with CHD, lack of association with a known CHD risk factor, and successful replication. A genetic risk score (GRS) was constructed based on these SNPs. Cox proportional hazards model was used to calculate CHD risk based on the Atherosclerosis Risk in Communities (ARIC) and Framingham CHD risk scores with and without the GRS. The GRS was associated with risk for CHD (hazard ratio [HR] = 1.10; 95% confidence interval [CI]: 1.07-1.13). Addition of the GRS to the ARIC risk score significantly improved discrimination, reclassification, and calibration beyond that afforded by TRFs alone in non-Hispanic whites in the ARIC study. The area under the receiver operating characteristic curve (AUC) increased from 0.742 to 0.749 (Δ = 0.007; 95% CI, 0.004-0.013), and the net reclassification index (NRI) was 6.3%. Although the risk estimates for CHD in the Framingham Offspring (HR = 1.12; 95% CI: 1.10-1.14) and Rotterdam (HR = 1.08; 95% CI: 1.02-1.14) Studies were significantly improved by adding the GRS to TRFs, improvements in AUC and NRI were modest. Addition of a GRS based on direct associations with CHD to TRFs significantly improved discrimination and reclassification in white participants of the ARIC Study, with no significant improvement in the Rotterdam and Framingham Offspring Studies. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  8. Deconstructing Rotterdam's modern city centre

    NARCIS (Netherlands)

    Van der Hoeven, F.D.

    2013-01-01

    In the 20th century, the Dutch city of Rotterdam was radically transformed from a historic town into a modern city, becoming the selfacclaimed 'city of architecture', home to international architectural design offices, publishers and institutions. Although it is already 60 years after the destructio

  9. Deconstructing Rotterdam's modern city centre

    NARCIS (Netherlands)

    Van der Hoeven, F.D.

    2013-01-01

    In the 20th century, the Dutch city of Rotterdam was radically transformed from a historic town into a modern city, becoming the selfacclaimed 'city of architecture', home to international architectural design offices, publishers and institutions. Although it is already 60 years after the destructio

  10. Philosophy of race meets population genetics.

    Science.gov (United States)

    Spencer, Quayshawn

    2015-08-01

    In this paper, I respond to four common semantic and metaphysical objections that philosophers of race have launched at scholars who interpret recent human genetic clustering results in population genetics as evidence for biological racial realism. I call these objections 'the discreteness objection', 'the visibility objection', 'the very important objection', and 'the objectively real objection.' After motivating each objection, I show that each one stems from implausible philosophical assumptions about the relevant meaning of 'race' or the nature of biological racial realism. In order to be constructive, I end by offering some advice for how we can productively critique attempts to defend biological racial realism based on recent human genetic clustering results. I also offer a clarification of the relevant human-population genetic research.

  11. The Rotterdam criteria for polycystic ovary syndrome: evidence-based criteria?

    Science.gov (United States)

    Wang, Rui; Mol, Ben Willem J

    2017-02-01

    The Rotterdam criteria for polycystic ovary syndrome (PCOS) are used by a wide range of medical professionals and researchers. However, the development of these criteria was based on expert meetings and not on evidence-based treatment guidance. Over the last decade, the Rotterdam criteria have been useful in guiding research, and a number of clinical studies on PCOS have been published consequently. We plead to revisit the Rotterdam criteria based on the available evidence in prognostic studies and randomized controlled trials. In this opinion paper, we provide arguments of the strengths and limitations of the Rotterdam criteria in guiding treatment selections and predicting prognoses in women with infertility. While the Rotterdam criteria have shown their advantages in predicting reproductive prognosis, the next step is to evaluate whether they can guide treatment choices in infertility as well as other health aspects of the syndrome. Based on available data in clinical studies, we should be able to determine whether the Rotterdam criteria are evidence-based criteria.

  12. Interacting personalities: behavioural ecology meets quantitative genetics.

    Science.gov (United States)

    Dingemanse, Niels J; Araya-Ajoy, Yimen G

    2015-02-01

    Behavioural ecologists increasingly study behavioural variation within and among individuals in conjunction, thereby integrating research on phenotypic plasticity and animal personality within a single adaptive framework. Interactions between individuals (cf. social environments) constitute a major causative factor of behavioural variation at both of these hierarchical levels. Social interactions give rise to complex 'interactive phenotypes' and group-level emergent properties. This type of phenotype has intriguing evolutionary implications, warranting a cohesive framework for its study. We detail here how a reaction-norm framework might be applied to usefully integrate social environment theory developed in behavioural ecology and quantitative genetics. The proposed emergent framework facilitates firm integration of social environments in adaptive research on phenotypic characters that vary within and among individuals.

  13. New concepts for Rotterdam port; Frachtwechsel

    Energy Technology Data Exchange (ETDEWEB)

    Heup, Juergen; Wiedemann, Karsten

    2012-05-15

    Rotterdam used to be the world's biggest seaport, but due to an economic crisis and increasing competition the Netherlands lost their leading position. Investments in bioenergy are to help overcome the crisis.

  14. Femininity as city marketing strategy: gender bending Rotterdam

    NARCIS (Netherlands)

    van den Berg, M.

    2012-01-01

    Rotterdam organised the festival ‘La City’ as an entrepreneurial strategy to upgrade the city’s class position, using femininity as a tool. ‘La City’ was an attempt to introduce a new economy in Rotterdam: one that is service-based and post-industrial. Rotterdam is a former industrial city and is

  15. Femininity as city marketing strategy: gender bending Rotterdam

    NARCIS (Netherlands)

    van den Berg, M.

    2012-01-01

    Rotterdam organised the festival ‘La City’ as an entrepreneurial strategy to upgrade the city’s class position, using femininity as a tool. ‘La City’ was an attempt to introduce a new economy in Rotterdam: one that is service-based and post-industrial. Rotterdam is a former industrial city and is no

  16. Modelsimulaties van het stadsklimaat van Rotterdam

    NARCIS (Netherlands)

    Ronda, R.J.; Steeneveld, G.J.; Hove, van B.

    2010-01-01

    Modelsimulaties zijn uitgevoerd ter inschatting van het Urban Heat Island effect van Rotterdam. Hiervoor is de meest recente versie van het Weather Research & Forecasting (WRF) model gebruikt dat is uitgerust met een Urban Canopy Model. Bovendien is gebruik gemaakt van specifieke stadeigenschapp

  17. Erasmus University Rotterdam Wrestles With Sustainability Strategy

    NARCIS (Netherlands)

    G. Coughlan (Geraldine); T. Yue (Tao); F.H. Wijen (Frank)

    2014-01-01

    textabstractErasmus University Rotterdam (EUR) is in the midst of a sustainability dilemma. The university is in a stage of transition, shifting focus from the city to the world stage. EUR’s current environmental sustainability policy needs more impetus. The university wants to incorporate

  18. Erasmus University Rotterdam Wrestles With Sustainability Strategy

    NARCIS (Netherlands)

    G. Coughlan (Geraldine); T. Yue (Tao); F.H. Wijen (Frank)

    2014-01-01

    textabstractErasmus University Rotterdam (EUR) is in the midst of a sustainability dilemma. The university is in a stage of transition, shifting focus from the city to the world stage. EUR’s current environmental sustainability policy needs more impetus. The university wants to incorporate sustainab

  19. 75 FR 21002 - Notice of Meeting: Secretary's Advisory Committee on Genetics, Health, and Society

    Science.gov (United States)

    2010-04-22

    ... Genetics, Health, and Society Pursuant to Public Law 92-463, notice is hereby given of the twenty-second meeting of the Secretary's Advisory Committee on Genetics, Health, and Society (SACGHS), U.S. Public... wishing to provide public comment on any issue related to genetics, health and society. Please note...

  20. 75 FR 52949 - Notice of Meeting: Secretary's Advisory Committee on Genetics, Health, and Society

    Science.gov (United States)

    2010-08-30

    ... Genetics, Health, and Society Pursuant to Public Law 92-463, notice is hereby given of the twenty-third meeting of the Secretary's Advisory Committee on Genetics, Health, and Society (SACGHS), U.S. Public... wishing to provide public comment on any issue related to genetics, health and society. Please note...

  1. Dietary antioxidants and peripheral arterial disease : the Rotterdam Study

    NARCIS (Netherlands)

    K. Klipstein-Grobusch (Kerstin); J.H. den Breeijen; D.E. Grobbee (Diederick); H. Boeing; J.C.M. Witteman (Jacqueline); A. Hofman (Albert)

    2001-01-01

    textabstractThis study examined cross-sectionally the association of dietary beta-carotene, vitamin C, and vitamin E with peripheral arterial disease in Rotterdam, the Netherlands (1990--1993). The 4,367 subjects from the Rotterdam Study were aged 55--94 years and had n

  2. The Rotterdam Scan Study: design update 2016 and main findings

    NARCIS (Netherlands)

    Ikram, M.A.; Van der Lugt, A.; Niessen, W.J.; Koudstaal, P.J.; Krestin, G.P.; Hofman, A.; Bos, D.; Vernooij, M.W.

    2015-01-01

    Imaging plays an essential role in research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to elucidate the causes of neurological disease by performing imaging of the brain in a prospective population-based setting

  3. The impact of world trade on the Port of Rotterdam and the wider region of Rotterdam-Rijnmond

    NARCIS (Netherlands)

    Heijman, Wim; Gardebroek, Koos; Os, van Wouter

    2017-01-01

    We study the economic impact of world trade on the throughput in the Port of Rotterdam and the regional economy of Rotterdam-Rijnmond. We use a two-step approach. In the first step we analyze the relationship between world trade and the port's throughput. In the second step we deal with the impac

  4. The Pauluskerk: an unorthodox church in Rotterdam

    Directory of Open Access Journals (Sweden)

    Frank van der Hoeven

    2014-05-01

    Full Text Available The tale of the rebuilding of the Pauluskerk (St. Paul’s Church in the Dutch city of Rotterdam is a multilayered story that blurs the lines between architecture, societal issues, policymaking and urban redevelopment.The original Pauluskerk was built in the late 1950s in a city centre that was still recovering from the damage it suffered during the Second World War. The church may never have received the attention it has were it not for Reverend Visser, who developed the church into a refuge for the outcasts of Dutch society: asylum seekers, homeless people and drug addicts. Visser’s activism eventually evolved into the Perron Nul (Platform Zero initiative, through which he organized support for the addicted and indigent on a scale not seen before in the city.The close proximity of the Pauluskerk to Rotterdam Central Station and the controversy surrounding its mission brought it slowly but steadily onto a collision course with the renewal and redevelopment of the station area, which would eventually lead to the demolition of the original Pauluskerk in 2007 and the construction of a new church building as part of the CalypSO project, designed by British architect William Alsop.This article brings these story lines together to showcase the complex process involved in an inner-city urban development founded in the well-established practice of local democracy, where consensus-seeking is the norm, even when this crosses societal borders.

  5. Glossogeny and phylogeny: cultural evolution meets genetic evolution.

    Science.gov (United States)

    Fitch, W Tecumseh

    2008-08-01

    Evolutionary theorists since Darwin have been interested in the parallels and interactions between biological and cultural evolution. Recent applications of empirical techniques originally developed to analyze molecular genetic data to linguistic data offer new insights into the historical evolution of language, revealing fascinating parallels between language change and biological evolution. This work offers considerable potential toward unified theories of genetic and cultural change.

  6. 75 FR 21295 - Notice of Meeting: Secretary's Advisory Committee on Genetics, Health, and Society

    Science.gov (United States)

    2010-04-23

    ..., Health, and Society Pursuant to Public Law 92-463, notice is hereby given of the twenty-second meeting of the Secretary's Advisory Committee on Genetics, Health, and Society (SACGHS), U.S. Public Health... wishing to provide public comment on any issue related to genetics, health and society. Please note...

  7. What to Expect When Meeting with a Genetic Counselor

    Science.gov (United States)

    ... you more information about your risk of these types of cancer Testing procedure limitations and accuracy of genetic tests Emotional, psychological, and social consequences of knowing the test results ...

  8. Medische technologie in de Medische Faculteit te Rotterdam

    NARCIS (Netherlands)

    C.J. Snijders (Chris)

    1984-01-01

    textabstractRede, uitgesproken bij de aanvaarding van het ambt van Gewoon Hoogleraar in de Medische Technologie aan de Faculteit der Geneeskunde van de Erasmus Universiteit Rotterdam, op 14 november 1984

  9. De Rotterdam: Creating a smartphone application to locate colleagues

    NARCIS (Netherlands)

    Oliveti, M.; Abhilakh Missier, G.; Mulder, D.; Zervakis, D.; Wu, H.; Van der Spek, S.C.; Verbree, E.; Zlatanova, S.; Poll-van Dasselaar, R.

    2014-01-01

    This Geomatics project was carried out in commission of the Municipality of Rotterdam, Geofort Herwijnen and Facility Management of TU Delft. The research project and this report deliver important fundamental information for scientific/academic paper on Wifi tracking.

  10. The Erasmus Computing Grid - Building a Super-Computer Virtually for Free at the Erasmus Medical Center and the Hogeschool Rotterdam

    NARCIS (Netherlands)

    T.A. Knoch (Tobias); L.V. de Zeeuw (Luc)

    2006-01-01

    textabstractThe Set-Up of the 20 Teraflop Erasmus Computing Grid: To meet the enormous computational needs of live- science research as well as clinical diagnostics and treatment the Hogeschool Rotterdam and the Erasmus Medical Center are currently setting up one of the largest desktop

  11. The Erasmus Computing Grid - Building a Super-Computer Virtually for Free at the Erasmus Medical Center and the Hogeschool Rotterdam

    NARCIS (Netherlands)

    T.A. Knoch (Tobias); L.V. de Zeeuw (Luc)

    2006-01-01

    textabstractThe Set-Up of the 20 Teraflop Erasmus Computing Grid: To meet the enormous computational needs of live- science research as well as clinical diagnostics and treatment the Hogeschool Rotterdam and the Erasmus Medical Center are currently setting up one of the largest desktop computing

  12. Sperm Meets Egg: The Genetics of Mammalian Fertilization.

    Science.gov (United States)

    Bianchi, Enrica; Wright, Gavin J

    2016-11-23

    Fertilization is the culminating event of sexual reproduction, which involves the union of the sperm and egg to form a single, genetically distinct organism. Despite the fundamental role of fertilization, the basic mechanisms involved have remained poorly understood. However, these mechanisms must involve an ordered schedule of cellular recognition events between the sperm and egg to ensure successful fusion. In this article, we review recent progress in our molecular understanding of mammalian fertilization, highlighting the areas in which genetic approaches have been particularly informative and focusing especially on the roles of secreted and cell surface proteins, expressed in a sex-specific manner, that mediate sperm-egg interactions. We discuss how the sperm interacts with the female reproductive tract, zona pellucida, and the oolemma. Finally, we review recent progress made in elucidating the mechanisms that reduce polyspermy and ensure that eggs normally fuse with only a single sperm.

  13. Darwin Meets Einstein: LISA Data Analysis Using Genetic Algorithms

    CERN Document Server

    Crowder, J; Reddinger, L; Cornish, Neil J.; Crowder, Jeff; Reddinger, Lucas

    2006-01-01

    This work presents the first application of the method of Genetic Algorithms (GAs) to data analysis for the Laser Interferometer Space Antenna (LISA). In the low frequency regime of the LISA band there are expected to be tens of thousands galactic binary systems that will be emitting gravitational waves detectable by LISA. The challenge of parameter extraction of such a large number of sources in the LISA data stream requires a search method that can efficiently explore the large parameter spaces involved. As signals of many of these sources will overlap, a global search method is desired. GAs represent such a global search method for parameter extraction of multiple overlapping sources in the LISA data stream. We find that GAs are able to correctly extract source parameters for overlapping sources. Several optimizations of a basic GA are presented with results derived from applications of the GA searches to simulated LISA data.

  14. Gait patterns in COPD: the Rotterdam Study.

    Science.gov (United States)

    Lahousse, Lies; Verlinden, Vincentius J A; van der Geest, Jos N; Joos, Guy F; Hofman, Albert; Stricker, Bruno H C; Brusselle, Guy G; Ikram, M Arfan

    2015-07-01

    Gait disturbances in patients with chronic obstructive pulmonary disease (COPD) may lead to disability and falls. As studies assessing gait kinematics in COPD are sparse, we investigated associations of COPD with various gait domains and explored a potential link with falling. Gait was measured within the prospective, population-based Rotterdam Study (age ≥55 years) using an electronic walkway and summarised into seven gait domains: Rhythm, Variability, Phases, Pace, Tandem, Turning and Base of Support. Rhythm is a temporal gait aspect that includes cadence and reflects how quickly steps are taken. Persons with COPD (n=196) exhibited worse Rhythm (-0.21 SD, 95% CI -0.36- -0.06 SD) compared with persons with normal lung function (n=898), independent of age, sex, height, education, smoking or analgesic use, especially when dyspnoea and severe airflow limitation or frequent exacerbations (Global Initiative for Chronic Obstructive Lung Disease group D: -0.83 SD, 95% CI -1.25- -0.41 SD) were present. A lower forced expiratory volume in 1 s was associated with worse Rhythm and Pace, including lower cadence and gait velocity, respectively. Importantly, fallers with COPD had significantly worse Rhythm than nonfallers with COPD. This study demonstrates that persons with COPD exhibit worse Rhythm, especially fallers with COPD. The degree of Rhythm deterioration was associated with the degree of airflow limitation, symptoms and frequency of exacerbations.

  15. Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study

    NARCIS (Netherlands)

    R. van Leeuwen (Redmer); M.K. Ikram (Kamran); J.R. Vingerling (Hans); J.C.M. Witteman (Jacqueline); P.T.V.M. de Jong (Paulus); A. Hofman (Albert)

    2003-01-01

    textabstractPURPOSE: To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS: The study was performed within the Rotterdam Study, a population-based, prospective cohort study in Rotterdam, The Netherlan

  16. LMNA cardiomyopathy: cell biology and genetics meet clinical medicine.

    Science.gov (United States)

    Lu, Jonathan T; Muchir, Antoine; Nagy, Peter L; Worman, Howard J

    2011-09-01

    Mutations in the LMNA gene, which encodes A-type nuclear lamins (intermediate filament proteins expressed in most differentiated somatic cells), cause a diverse range of diseases, called laminopathies, that selectively affect different tissues and organ systems. The most prevalent laminopathy is cardiomyopathy with or without different types of skeletal muscular dystrophy. LMNA cardiomyopathy has an aggressive clinical course with higher rates of deadly arrhythmias and heart failure than most other heart diseases. As awareness among physicians increases, and advances in DNA sequencing methods make the genetic diagnosis of LMNA cardiomyopathy more common, cardiologists are being faced with difficult questions regarding patient management. These questions concern the optimal use of intracardiac cardioverter defibrillators to prevent sudden death from arrhythmias, and medical interventions to prevent heart damage and ameliorate heart failure symptoms. Data from a mouse model of LMNA cardiomyopathy suggest that inhibitors of mitogen-activated protein kinase (MAPK) signaling pathways are beneficial in preventing and treating cardiac dysfunction; this basic research discovery needs to be translated to human patients.

  17. LMNA cardiomyopathy: cell biology and genetics meet clinical medicine

    Directory of Open Access Journals (Sweden)

    Jonathan T. Lu

    2011-09-01

    Full Text Available Mutations in the LMNA gene, which encodes A-type nuclear lamins (intermediate filament proteins expressed in most differentiated somatic cells, cause a diverse range of diseases, called laminopathies, that selectively affect different tissues and organ systems. The most prevalent laminopathy is cardiomyopathy with or without different types of skeletal muscular dystrophy. LMNA cardiomyopathy has an aggressive clinical course with higher rates of deadly arrhythmias and heart failure than most other heart diseases. As awareness among physicians increases, and advances in DNA sequencing methods make the genetic diagnosis of LMNA cardiomyopathy more common, cardiologists are being faced with difficult questions regarding patient management. These questions concern the optimal use of intracardiac cardioverter defibrillators to prevent sudden death from arrhythmias, and medical interventions to prevent heart damage and ameliorate heart failure symptoms. Data from a mouse model of LMNA cardiomyopathy suggest that inhibitors of mitogen-activated protein kinase (MAPK signaling pathways are beneficial in preventing and treating cardiac dysfunction; this basic research discovery needs to be translated to human patients.

  18. Developing the Rotterdam City Region Food System: acting and thinking at the same time

    NARCIS (Netherlands)

    Schans, van der J.W.

    2015-01-01

    The city region of Rotterdam is located in the western part of the Netherlands, bordering the North Sea. It contains the municipality of Rotterdam and several neighbouring municipalities, with about 1.2 million inhabitants. Rotterdam hosts Europe’s largest sea port as well as a large (inland-oriente

  19. Meeting Report: The 24th Fungal Genetics Conference at Asilomar, California, USA

    Institute of Scientific and Technical Information of China (English)

    XU Jian-Ping

    2007-01-01

    @@ The 24th Fungal Genetics Conference was recently held at the Asilomar Conference Center in the coastal town of Pacific Grove, Monterey County, California, USA, between March 20th and 25th, 2007. At this conference, there were 750 participants representing 33 countries, with the number of participants reaching the maximum holding capacity of the conference center. About 200 people were on the waiting list and could not attend the meeting because of space limitations.

  20. Performance Effects of the Corporatisation of Port of Rotterdam Authority

    NARCIS (Netherlands)

    P.W. de Langen (Peter); C. Heij (Christiaan)

    2013-01-01

    textabstractPort of Rotterdam Authority is a publicly owned but corporatized port development company. In 2004, this organisation was transformed from a municipal department to an independently operating company. The corporatisation intended to improve the overall performance of the port of Rotterda

  1. Dietary acid load and risk of hypertension : the Rotterdam Study

    NARCIS (Netherlands)

    Engberink, Marielle F.; Bakker, Stephan J. L.; Brink, Elizabeth J.; van Baak, Marleen A.; van Rooij, Frank J. A.; Hofman, Albert; Witteman, Jacqueline C. M.; Geleijnse, Johanna M.

    2012-01-01

    Background: Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP). Objective: The objective was to examine whether dietary acid load was associated with incident hypertension in a cohort of older Dutch adults from the Rotterdam Study. Design: The analyses i

  2. Dietary acid load and risk of hypertension: The Rotterdam study

    NARCIS (Netherlands)

    M.F. Engberink (Marielle); S.J.L. Bakker (Stephan); E.J. Brink (Elizabeth); M.A. van Baak (Marleen); F.J.A. van Rooij (Frank); A. Hofman (Albert); J.C.M. Witteman (Jacqueline); J.M. Geleijnse (Marianne)

    2012-01-01

    textabstractBackground: Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP). Objective: The objective was to examine whether dietary acid load was associated with incident hypertension in a cohort of older Dutch adults from the Rotterdam Study. Design: Th

  3. Dietary acid load and risk of hypertension: The Rotterdam study

    NARCIS (Netherlands)

    Engberink, M.F.; Bakker, S.J.L.; Brink, E.J.; Baak, M.A. van; Rooij, F.J.A. van; Hofman, A.; Witteman, J.C.M.; Geleijnse, J.M.

    2012-01-01

    Background: Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP). Objective: The objective was to examine whether dietary acid load was associated with incident hypertension in a cohort of older Dutch adults from the Rotterdam Study. Design: The analyses i

  4. The Rotterdam Rules from an Estonian perspective / Heiki Lindpere

    Index Scriptorium Estoniae

    Lindpere, Heiki, 1949-

    2010-01-01

    Rotterdami reeglite (Konventsioon lepingute kohta kaupade rahvusvaheliseks veoks täies ulatuses või osaliselt meritsi = Convention on Contracts for the International Carriage of Goods Wholly or Partly by Sea (Rotterdam Rules)) tähtsusest Eestile ja kaubaveo reguleerimisest Eesti õiguses

  5. Sustainable densification and greenification in the inner city of Rotterdam

    NARCIS (Netherlands)

    Beurden, J.B.V.; Doepel, D.; Tillie, N.

    2013-01-01

    Many cities are developing and implementing plans for urban restructuring and densification. The Municipality of Rotterdam has explored a number of strategies with the aim of creating a more attractive, lively city centre through densification and greenification. This study has researched what the

  6. The Rotterdam Rules from an Estonian perspective / Heiki Lindpere

    Index Scriptorium Estoniae

    Lindpere, Heiki, 1949-

    2010-01-01

    Rotterdami reeglite (Konventsioon lepingute kohta kaupade rahvusvaheliseks veoks täies ulatuses või osaliselt meritsi = Convention on Contracts for the International Carriage of Goods Wholly or Partly by Sea (Rotterdam Rules)) tähtsusest Eestile ja kaubaveo reguleerimisest Eesti õiguses

  7. Vienna-Rotterdam: Forging the Future Urban strategies compared

    NARCIS (Netherlands)

    Rosemann, J.; Wigmans, G.

    1996-01-01

    De rol van de publieke planning en de mogelijkheid (en ook de wenselijkheid) om de stedelijke ontwikkeling in het postindustriële tijdperk te sturen zijn de centrale thema's van de conferentie "Vienna - Rotterdam: Forging the Future". De conferentie wordt georganiseerd door de bouwkundefaculteiten v

  8. Pion of pionier, Rotterdam - Gemeentelijke bedrijvigheid in de negentiende eeuw

    NARCIS (Netherlands)

    Noort, Jan van den

    1990-01-01

    Pawn or pioneer, Rotterdam - municipal activity in the 19th century. The liberal watchword 'laissez-faire' gives succinct sum and substance to the preference that nineteenth century liberal administrators had for state restraint. Society was well served, they believed, when government took a modest

  9. Sustainable densification and greenification in the inner city of Rotterdam

    NARCIS (Netherlands)

    Beurden, J.B.V.; Doepel, D.; Tillie, N.

    2013-01-01

    Many cities are developing and implementing plans for urban restructuring and densification. The Municipality of Rotterdam has explored a number of strategies with the aim of creating a more attractive, lively city centre through densification and greenification. This study has researched what the a

  10. 3D Spatial Information Infrastructure for the Port of Rotterdam

    NARCIS (Netherlands)

    Zlatanova, S.; Beetz, J.; Boersma, A.J.; Mulder, A.; Goos, J.

    2013-01-01

    The maintenance of the complex infrastructure and facilities of Port of Rotterdam is based on large amounts of heterogeneous information. Almost all activities of the Port require spatial information about features above- and under- ground. Current information systems are department and data oriente

  11. 3D spatial information infrastructure: The case of Port Rotterdam

    NARCIS (Netherlands)

    Zlatanova, S.; Beetz, J.

    2012-01-01

    The development and maintenance of the infrastructure, facilities, logistics and other assets of the Port of Rotterdam requires a broad spectrum of heterogeneous information. This information concerns features, which are spatially distributed above ground, underground, in the air and in the water. T

  12. Dietary patterns and changes in frailty status: the Rotterdam study

    NARCIS (Netherlands)

    de Haas, S.C.M. (Sandra C. M.); E.A.L. de Jonge (Ester); R.G. Voortman (Trudy); J.C.J. Steenweg-de Graaff (Jolien); Franco, O.H. (Oscar H.); M.A. Ikram (Arfan); Rivadeneira, F. (Fernando); J.C. Kiefte-de Jong (Jessica); J.D. Schoufour (Josje)

    2017-01-01

    textabstractPurpose: To determine the associations between a priori and a posteriori derived dietary patterns and a general state of health, measured as the accumulation of deficits in a frailty index. Methods: Cross-sectional and longitudinal analysis embedded in the population-based Rotterdam

  13. De verwildering van Ailanthus altissima (Mill.) Swingle (Hemelboom) in Rotterdam

    NARCIS (Netherlands)

    Andeweg, Remko

    1997-01-01

    The Tree-of-heaven is widely naturalized in South- and Southeast-Europe and has its Northwestern border in Germany, with outposts in urban environments. This area is expected to spread towards the Netherlands. Recent discovery of seedlings in Rotterdam and other places may show a start of this

  14. The Maritime Performing Party in the Rotterdam Rules 2009

    NARCIS (Netherlands)

    F.G.M. Smeele (Frank)

    2010-01-01

    textabstractINTRODUCTION. In an attempt to deal uniformly with several complex and delicate legal issues that have divided the seafaring nations of the world for most of the last century, the Rotterdam Rules 2009 (hereafter: RR) introduce the concept of the “maritime performing party”. This is a

  15. Dietary acid load and risk of hypertension : the Rotterdam Study

    NARCIS (Netherlands)

    Engberink, Marielle F.; Bakker, Stephan J. L.; Brink, Elizabeth J.; van Baak, Marleen A.; van Rooij, Frank J. A.; Hofman, Albert; Witteman, Jacqueline C. M.; Geleijnse, Johanna M.

    Background: Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP). Objective: The objective was to examine whether dietary acid load was associated with incident hypertension in a cohort of older Dutch adults from the Rotterdam Study. Design: The analyses

  16. Responsible innovation in port development: the Rotterdam Maasvlakte 2 and the Dalian Dayao Bay extension projects.

    Science.gov (United States)

    Ravesteijn, Wim; Liu, Yi; Yan, Ping

    2015-01-01

    The paper outlines and specifies 'responsible port innovation', introducing the development of a methodological and procedural step-by-step plan for the implementation and evaluation of (responsible) innovations. Subsequently, it uses this as a guideline for the analysis and evaluation of two case-studies. The construction of the Rotterdam Maasvlakte 2 Port meets most of the formulated requirements, though making values more explicit and treating it as a process right from the start could have benefitted the project. The Dalian Dayao Port could improve its decision-making procedures in several respects, including the introduction of new methods to handle value tensions. Both projects show that public support is crucial in responsible port innovation and that it should be not only a multi-faceted but also a multi-level strategy.

  17. Genetic determinants of arterial stiffness: Results from the Rotterdam Study

    NARCIS (Netherlands)

    M.P.S. Sie (Mark)

    2007-01-01

    textabstractArterial stiffness increases with age. It is also associated with various diseases, such as diabetes mellitus and hypertension. Recently, arterial stiffness has also been found to independently predict cardiovascular disease. The pathogenesis of arterial stiffness, however, has n

  18. Genetically modified crops for the bioeconomy: meeting public and regulatory expectations.

    Science.gov (United States)

    Chapotin, Saharah Moon; Wolt, Jeffrey D

    2007-12-01

    As the United States moves toward a plant-based bioeconomy, a large research and development effort is focused on creating new feedstocks to meet biomass demand for biofuels, bioenergy, and specialized bioproducts, such as industrial compounds and biomaterial precursors. Most bioeconomy projections assume the widespread deployment of novel feedstocks developed through the use of modern molecular breeding techniques, but rarely consider the challenges involved with the use of genetically modified crops, which can include hurdles due to regulatory approvals, market adoption, and public acceptance. In this paper we consider the implications of various transgenic crops and traits under development for the bioeconomy that highlight these challenges. We believe that an awareness of the issues in crop and trait selection will allow developers to design crops with maximum stakeholder appeal and with the greatest potential for widespread adoption, while avoiding applications unlikely to meet regulatory approval or gain market and public acceptance.

  19. 76 FR 6623 - Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-02-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Molecular and Clinical Genetics Panel of the Medical Devices... (FDA). The meeting will be open to the public. Name of Committee: Molecular and Clinical Genetics...

  20. The society for craniofacial genetics and developmental biology 39th annual meeting.

    Science.gov (United States)

    Fish, Jennifer L; Albertson, Craig; Harris, Matthew P; Lozanoff, Scott; Marcucio, Ralph S; Richtsmeier, Joan T; Trainor, Paul A

    2017-02-07

    The Society for Craniofacial Genetics and Developmental Biology (SCGDB) aims to promote education, research, and communication, about normal and abnormal development of the tissues and organs of the head. Membership of the SCGDB is broad and diverse-including clinicians, orthodontists, scientists, and academics-but with all members sharing an interest in craniofacial biology. Each year, the SCGDB hosts a meeting where members can share their latest research, exchange ideas and resources, and build on or establish new collaborations. © 2016 Wiley Periodicals, Inc.

  1. 3D spatial information infrastructure: The case of Port Rotterdam

    Science.gov (United States)

    Zlatanova, S.; Beetz, J.

    2012-10-01

    The development and maintenance of the infrastructure, facilities, logistics and other assets of the Port of Rotterdam requires a broad spectrum of heterogeneous information. This information concerns features, which are spatially distributed above ground, underground, in the air and in the water. The data are managed in a variety of data models with varying levels of dimensionality, granularity, accuracy and up-to-dateness. Additionally increasing number of 3D design models is becoming available. This complexity of tasks and diversity of information challenges the Port authority to look for more advanced 3D solutions. This paper presents research in progress related to developing a 3D SII in support of information and process management within the Port of Rotterdam.

  2. Happy Protest Voters: The Case of Rotterdam 1997-2009.

    Science.gov (United States)

    Ouweneel, Piet; Veenhoven, Ruut

    Protest parties are on the rise in several European countries. This development is commonly attributed to a growing dissatisfaction with life and associated with declining quality of life in modern society of the lowest social strata. This explanation is tested in a cross-sectional analysis of voting and life-satisfaction in 63 districts of the city of Rotterdam in the Netherlands, where the share of protest voters increased from 10 % in 1994 to 31 % in 2009. Contrary to this explanation protest voting appeared not to be the most frequent in the least happy districts of Rotterdam, but in the medium happy segment. Also divergent from this explanation was that average happiness in city districts is largely independent of local living conditions, but is rather a matter of personal vulnerability in terms of education, income and health. These results fit alternative explanations in terms of middle class status anxiety.

  3. On the Red Carpet. Expats in Rotterdam and The Hague

    OpenAIRE

    Bochove, Marianne; Rusinovic, Katja; Engbersen, Godfried

    2011-01-01

    textabstractIntroduction: In a range of Dutch cities, in recent years a policy has been developed which is specifically directed to knowledge workers or expatriates – often simply called expats. Special expat information centers were opened in, among other cities, The Hague, Amsterdam, Nijmegen, Leiden and Eindhoven. Rotterdam, the city which forms the central focus of this research, established an Expat Desk at the end of 2008. Although differences exist regarding the exact design of such ex...

  4. The Imaging and Cognition Genetics Conference 2011, ICG 2011: A Meeting of Minds.

    Science.gov (United States)

    Le Hellard, Stéphanie; Hanson, Isabel

    2012-01-01

    In June 2011, 70 researchers from the disciplines of cognitive science, genetics, psychology, psychiatry, neurobiology, and computer science gathered in Os, Norway, for the first Imaging and Cognition Genetics meeting. The aim of the conference was to discuss progress, enhance collaboration, and maximize the sharing of resources within this new field. In this Perspective, we summarize the major themes that emerged from ICG 2011. The first is the importance of defining cognitive and imaging phenotypes and endophenotypes suitable for genetic analysis. These can come from differential psychology, cognitive science, structural MRI, tractography, and functional imaging. The second theme is the emergence of new methods for the analysis of complex traits. These include advanced computational and statistical techniques for analyzing complex datasets, and new ways of interpreting data from genome-wide association studies, such as jointly evaluating the contribution of SNPs in specific genes and pathways rather than considering single SNPs in isolation. The final theme is the importance of establishing functional correlates of newly identified genetic variants.

  5. Meetings

    Institute of Scientific and Technical Information of China (English)

    HUGuowen; QINPeng; FENGYilun

    1994-01-01

    The International Workshop on Rice Sheath Bright Management was held in the Experimental Farm of CNRRI from Oct 10 to 15, 1993. The workshop was sponsored by IRRI and co-hosted by CNRRI. About 38 scientists from IRRI, Indonesia, South Korea, Thailand, Vietnam,Japan, Great Britain, France, Malaysia and P. R. China attended the meeting.

  6. Setaria Comes of Age: Meeting Report on the Second International Setaria Genetics Conference

    Directory of Open Access Journals (Sweden)

    Chuanmei Zhu

    2017-09-01

    Full Text Available Setaria viridis is an emerging model for cereal and bioenergy grasses because of its short stature, rapid life cycle and expanding genetic and genomic toolkits. Its close phylogenetic relationship with economically important crops such as maize and sorghum positions Setaria as an ideal model system for accelerating discovery and characterization of crop genes that control agronomically important traits. The Second International Setaria Genetics Conference was held on March 6–8, 2017 at the Donald Danforth Plant Science Center, St. Louis, MO, United States to discuss recent technological breakthroughs and research directions in Setaria (presentation abstracts can be downloaded at https://www.brutnelllab.org/setaria. Here, we highlight topics presented in the conference including inflorescence architecture, C4 photosynthesis and abiotic stress. Genetic and genomic toolsets including germplasm, mutant populations, transformation and gene editing technologies are also discussed. Since the last meeting in 2014, the Setaria community has matured greatly in the quality of research being conducted. Outreach and increased communication with maize and other plant communities will allow broader adoption of Setaria as a model system to translate fundamental discovery research to crop improvement.

  7. Regional economic impact of an event: the case of the Rotterdam Marathon

    NARCIS (Netherlands)

    Willem, Jan; Goedknegt, Bart; Heijman, W.J.M.

    2016-01-01

    The Rotterdam Marathon is an annual sports event in Rotterdam. This biggest one-day event in the Netherlands attracted around 925,000 visitors in 2014. This paper aims at evaluating its regional economic impact by way of input output analysis in terms of number of jobs.

  8. Epidemiology of neurological diseases in elderly people: what did we learn from the Rotterdam Study?

    NARCIS (Netherlands)

    Hofman, A.; de Jong, P.T.V.M.; Duijn, C.M. van; Breteler, M.M.

    2006-01-01

    The Rotterdam Study is a prospective cohort study that has been ongoing since 1990 in the city of Rotterdam, the Netherlands, among 7983 people aged 55 years or older. One part of the study targets neurological diseases, others deal with cardiovascular, ophthalmological, and endocrine diseases. The

  9. Health impact assessment of transport policies in Rotterdam

    DEFF Research Database (Denmark)

    Tobollik, Myriam; Keuken, Menno; Sabel, Clive E;

    2016-01-01

    BACKGROUND: Green house gas (GHG) mitigation policies can be evaluated by showing their co-benefits to health. METHOD: Health Impact Assessment (HIA) was used to quantify co-benefits of GHG mitigation policies in Rotterdam. The effects of two separate interventions (10% reduction of private vehicle......: The evaluation of planned interventions, related to climate change policies, targeting only the transport sector can result in small co-benefits for health, if the analysis is limited to air pollution and noise. This urges to expand the analysis by including other impacts, e.g. physical activity and well...

  10. Happy Protest Voters: The Case of Rotterdam 1997?2009

    OpenAIRE

    Ouweneel, Piet; Veenhoven, Ruut

    2015-01-01

    textabstractProtest parties are on the rise in several European countries. This development is commonly attributed to a growing dissatisfaction with life and associated with declining quality of life in modern society of the lowest social strata. This explanation is tested in a cross-sectional analysis of voting and life-satisfaction in 63 districts of the city of Rotterdam in the Netherlands, where the share of protest voters increased from 10 % in 1994 to 31 % in 2009. Contrary to this expl...

  11. Meeting Quay 2k30's requirements

    NARCIS (Netherlands)

    Wijnants, G.H.; Toorn, A. van der; Schuylenburg, M.; Heijnen, H.P.J.; Gijt, J.G. de; Molenaar, W.F.; Ligteringen, H.; Krom, A.H.M.

    2005-01-01

    The requirements that a quay design should meet in order to yield a viable port infrastructure, vary widely from flexibility due to future customers requirements to durability due to owners requirements. In a Port of Rotterdam backed project, current and future requirements have been aggregated by c

  12. Rotterdam: main port for organ transplantation research in the Netherlands.

    Science.gov (United States)

    Kwekkeboom, Jaap; van der Laan, Luc J W; Betjes, Michiel G H; Manintveld, Olivier C; Hoek, Rogier A S; Cransberg, Karlien; de Bruin, Ron W F; Dor, Frank J M F; de Jonge, Jeroen; Boor, Patrick P C; van Gent, Rogier; van Besouw, Nicole M; Boer, Karin; Litjens, Nicolle H R; Hesselink, Dennis A; Hoogduijn, Martin J; Massey, Emma; Rowshani, Ajda T; van de Wetering, Jacqueline; de Jong, Huib; Hendriks, Rudi W; Metselaar, Herold J; van Gelder, Teun; Weimar, Willem; IJzermans, Jan N M; Baan, Carla C

    2014-10-01

    This overview describes the full spectrum of current pre-clinical and clinical kidney-, liver-, heart- and lung transplantation research performed in Erasmus MC - University Medical Centre in Rotterdam, The Netherlands. An update is provided on the development of a large living donor kidney transplantation program and on optimization of kidney allocation, including the implementation of a domino kidney-donation program. Our current research efforts to optimize immunosuppressive regimens and find novel targets for immunosuppressive therapy, our recent studies on prevention of ischemia-reperfusion-induced graft injury, our newest findings on stimulation of tissue regeneration, our novel approaches to prevent rejection and viral infection, and our latest insights in the regulation of allograft rejection, are summarized. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Annual City Festivals as Tools for Sustainable Competitiveness: The World Port Days Rotterdam

    National Research Council Canada - National Science Library

    van Tuijl, Erwin; van den Berg, Leo

    2016-01-01

    .... This article reviews a case study of the World Port Days in Rotterdam in order to demonstrate how annual city festivals can contribute to sustainable competitiveness, despite limitations as well...

  14. Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study

    NARCIS (Netherlands)

    M.P.M. de Maat (Moniek); M.L. Bots (Michiel); M.M.B. Breteler (Monique); J. Meijer (John); A.J. Kiliaan (Amanda); J.C.M. Witteman (Jacqueline); A. Hofman (Albert)

    2002-01-01

    textabstractInflammatory mediators and soluble cell adhesion molecules predict cardiovascular events. It is not clear whether they reflect the severity of underlying atherosclerotic disease. Within the Rotterdam Study, we investigated the associations of C-reactive protein (CRP), i

  15. Winst en verlies: een balans van 15 jaar neuro-oncologie in Rotterdam

    NARCIS (Netherlands)

    M.J. van den Bent (Martin)

    2007-01-01

    textabstractRede, in verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar in de Neuro-Oncologie aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 19 januari 2007

  16. Antihypertensive treatment is associated with improved left ventricular geometry: the Rotterdam Study.

    NARCIS (Netherlands)

    Bleumink, G.S.; Deinum, J.; Mosterd, A.; Witteman, J.C.; Hofman, A.W.I.M.; Stricker, B.H.C.

    2004-01-01

    PURPOSE: Left ventricular hypertrophy (LVH) increases the risk of cardiovascular disease. We evaluated the association between antihypertensive therapy and echocardiographically determined LVH. METHODS AND RESULTS: The Rotterdam Study is a population-based prospective cohort study among 7983

  17. Winst en verlies: een balans van 15 jaar neuro-oncologie in Rotterdam

    NARCIS (Netherlands)

    M.J. van den Bent (Martin)

    2007-01-01

    textabstractRede, in verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar in de Neuro-Oncologie aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 19 januari 2007

  18. Pathways and barriers to genetic testing and screening: Molecular genetics meets the high-risk family. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Duster, T.

    1998-11-01

    The proliferation of genetic screening and testing is requiring increasing numbers of Americans to integrate genetic knowledge and interventions into their family life and personal experience. This study examines the social processes that occur as families at risk for two of the most common autosomal recessive diseases, sickle cell disease (SC) and cystic fibrosis (CF), encounter genetic testing. Each of these diseases is found primarily in a different ethnic/racial group (CF in Americans of North European descent and SC in Americans of West African descent). This has permitted them to have a certain additional lens on the role of culture in integrating genetic testing into family life and reproductive planning. A third type of genetic disorder, the thalassemias was added to the sample in order to extent the comparative frame and to include other ethnic and racial groups.

  19. A census of cells in time: quantitative genetics meets developmental biology.

    Science.gov (United States)

    Chitwood, Daniel H; Sinha, Neelima R

    2013-02-01

    Quantitative genetics has become a popular method for determining the genetic basis of natural variation. Combined with genomic methods, it provides a tool for discerning the genetic basis of gene expression. So-called genetical genomics approaches yield a wealth of genomic information, but by necessity, because of cost and time, fail to resolve the differences between organs, tissues, and/or cell types. Similarly, quantitative approaches in development that might potentially address these issues are seldom applied to quantitative genetics. We discuss recent advances in cell type-specific isolation methods, the quantitative analysis of phenotype, and developmental modeling that are compatible with quantitative genetics and, with time, promise to bridge the gap between these two powerful disciplines yielding unprecedented biological insight.

  20. Normal spirometry values in healthy elderly: the Rotterdam Study.

    Science.gov (United States)

    Loth, Daan Willem; Ittermann, Till; Lahousse, Lies; Hofman, Albert; Leufkens, Hubert Gerardus Maria; Brusselle, Guy Gaston; Stricker, Bruno Hugo

    2013-04-01

    Although many different reference values for spirometry are available from various studies, the elderly are usually underrepresented. Therefore, our objective was to assess reference values in a sample of healthy participants from a prospective population-based cohort study, including a large proportion of elderly. We included spirometry measurements of healthy, never smokers, from the Rotterdam Study and excluded participants with respiratory symptoms or prescriptions for respiratory medication. Age- and height-specific curves for the 5th (lower limit of normal) and the 50th (median) percentile of Forced Expiratory Volume in 1 s (FEV1), Forced Vital Capacity (FVC), and the ratio (FEV1/FVC) were calculated by quantile regression models. The group of healthy elderly study subjects consisted of 1,125 individuals, with a mean age of 68 years, ranging from 47 to 96 years of age. Sex stratified equations for the median and the lower limit of normal were calculated adjusted for age and height. In this study, we report age- and height-dependent reference limits for FEV1, FVC, and FEV1/FVC in a large population, and prediction equations for the lower limit of normal and median values for a sample containing a large proportion of healthy elderly.

  1. Sedentary time assessed by actigraphy and mortality: The Rotterdam Study.

    Science.gov (United States)

    Koolhaas, Chantal M; Dhana, Klodian; van Rooij, Frank J A; Kocevska, Desana; Hofman, Albert; Franco, Oscar H; Tiemeier, Henning

    2017-02-01

    Research suggests that sedentary behavior is a risk factor for mortality. However, most studies rely on questionnaires, which are prone to reporting error. We examined the association between sedentary time assessed by actigraphy and mortality among 1839 participants, aged 45-98years, from the prospective population-based Rotterdam Study, enrolled between 2004 and 2007. Participants wore an actigraph around the wrist for seven days. Sedentary time was evaluated continuously, per 1h/day increase, and categorically in three groups (sedentary behavior and mortality over and beyond other activity measures (including physical activity (PA) and activities of daily living (ADL)) in a final model. During 11years of follow-up (median: 7.5years, interquartile range: 6.6-8.3years), 212 participants (11.5%) died. In the multivariable model, the hazard ratio (HR) and 95% confidence interval (95% CI) per 1 more hour/day sedentary time was 1.09 (1.00, 1.18). The HR (95% CI) after adjustment for PA and ADL was 1.04 (0.96, 1.13). Participants sedentary for ≥11h/day had a higher mortality risk (HR: 1.80, 95% CI: 1.14, 2.84) than those sedentary sedentary behavior is a risk factor for mortality. Further investigation is needed to examine whether this association is distinct from the effect of other measures of activity.

  2. Meeting review. Uncovering the genetic basis of adaptive change: on the intersection of landscape genomics and theoretical population genetics.

    Science.gov (United States)

    Joost, Stéphane; Vuilleumier, Séverine; Jensen, Jeffrey D; Schoville, Sean; Leempoel, Kevin; Stucki, Sylvie; Widmer, Ivo; Melodelima, Christelle; Rolland, Jonathan; Manel, Stéphanie

    2013-07-01

    A workshop recently held at the École Polytechnique Fédérale de Lausanne (EPFL, Switzerland) was dedicated to understanding the genetic basis of adaptive change, taking stock of the different approaches developed in theoretical population genetics and landscape genomics and bringing together knowledge accumulated in both research fields. Indeed, an important challenge in theoretical population genetics is to incorporate effects of demographic history and population structure. But important design problems (e.g. focus on populations as units, focus on hard selective sweeps, no hypothesis-based framework in the design of the statistical tests) reduce their capability of detecting adaptive genetic variation. In parallel, landscape genomics offers a solution to several of these problems and provides a number of advantages (e.g. fast computation, landscape heterogeneity integration). But the approach makes several implicit assumptions that should be carefully considered (e.g. selection has had enough time to create a functional relationship between the allele distribution and the environmental variable, or this functional relationship is assumed to be constant). To address the respective strengths and weaknesses mentioned above, the workshop brought together a panel of experts from both disciplines to present their work and discuss the relevance of combining these approaches, possibly resulting in a joint software solution in the future.

  3. Mission Status at Aura Science Team MOWG Meeting: EOS Aura

    Science.gov (United States)

    Fisher, Dominic

    2016-01-01

    Presentation at the 24797-16 Earth Observing System (EOS) Aura Science Team Meeting (Mission Operations Work Group (MOWG)) at Rotterdam, Netherlands August 29, 2016. Presentation topics include mission summary, spacecraft subsystems summary, recent and planned activities, spacecraft anomalies, data capture, propellant usage and lifetime estimates, spacecraft maneuvers and ground track history, mission highlights and past spacecraft anomalies and reliability estimates.

  4. Oil Pipelines, Politics and International Business : The Rotterdam Oil Port, Royal Dutch Shell and the German Hinterland, 1945-1975

    NARCIS (Netherlands)

    M. Boon (Marten)

    2014-01-01

    markdownabstractThe dissertation questions how and why the transition from coal to oil affected the economic relations between the Port of Rotterdam and its German hinterland between 1945 and 1975. From the 1880s onwards, Rotterdam had become the main seaport of the German industrial heartland in

  5. Oil Pipelines, Politics and International Business : The Rotterdam Oil Port, Royal Dutch Shell and the German Hinterland, 1945-1975

    NARCIS (Netherlands)

    M. Boon (Marten)

    2014-01-01

    markdownabstractThe dissertation questions how and why the transition from coal to oil affected the economic relations between the Port of Rotterdam and its German hinterland between 1945 and 1975. From the 1880s onwards, Rotterdam had become the main seaport of the German industrial heartland in th

  6. Parent-offspring conflict and co-adaptation: behavioural ecology meets quantitative genetics.

    Science.gov (United States)

    Smiseth, Per T; Wright, Jonathan; Kölliker, Mathias

    2008-08-22

    The evolution of the complex and dynamic behavioural interactions between caring parents and their dependent offspring is a major area of research in behavioural ecology and quantitative genetics. While behavioural ecologists examine the evolution of interactions between parents and offspring in the light of parent-offspring conflict and its resolution, quantitative geneticists explore the evolution of such interactions in the light of parent-offspring co-adaptation due to combined effects of parental and offspring behaviours on fitness. To date, there is little interaction or integration between these two fields. Here, we first review the merits and limitations of each of these two approaches and show that they provide important complementary insights into the evolution of strategies for offspring begging and parental resource provisioning. We then outline how central ideas from behavioural ecology and quantitative genetics can be combined within a framework based on the concept of behavioural reaction norms, which provides a common basis for behavioural ecologists and quantitative geneticists to study the evolution of parent-offspring interactions. Finally, we discuss how the behavioural reaction norm approach can be used to advance our understanding of parent-offspring conflict by combining information about the genetic basis of traits from quantitative genetics with key insights regarding the adaptive function and dynamic nature of parental and offspring behaviours from behavioural ecology.

  7. Mendel Meets CSI: Forensic Genotyping as a Method to Teach Genetics & DNA Science

    Science.gov (United States)

    Kurowski, Scotia; Reiss, Rebecca

    2007-01-01

    This article describes a forensic DNA science laboratory exercise for advanced high school and introductory college level biology courses. Students use a commercial genotyping kit and genetic analyzer or gene sequencer to analyze DNA recovered from a fictitious crime scene. DNA profiling and STR genotyping are outlined. DNA extraction, PCR, and…

  8. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

    Science.gov (United States)

    Gieger, Christian; Geistlinger, Ludwig; Altmaier, Elisabeth; Hrabé de Angelis, Martin; Kronenberg, Florian; Meitinger, Thomas; Mewes, Hans-Werner; Wichmann, H-Erich; Weinberger, Klaus M; Adamski, Jerzy; Illig, Thomas; Suhre, Karsten

    2008-11-01

    The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the physiological state of the human body. Genetic variants that associate with changes in the homeostasis of key lipids, carbohydrates, or amino acids are not only expected to display much larger effect sizes due to their direct involvement in metabolite conversion modification, but should also provide access to the biochemical context of such variations, in particular when enzyme coding genes are concerned. To test this hypothesis, we conducted what is, to the best of our knowledge, the first GWA study with metabolomics based on the quantitative measurement of 363 metabolites in serum of 284 male participants of the KORA study. We found associations of frequent single nucleotide polymorphisms (SNPs) with considerable differences in the metabolic homeostasis of the human body, explaining up to 12% of the observed variance. Using ratios of certain metabolite concentrations as a proxy for enzymatic activity, up to 28% of the variance can be explained (p-values 10(-16) to 10(-21)). We identified four genetic variants in genes coding for enzymes (FADS1, LIPC, SCAD, MCAD) where the corresponding metabolic phenotype (metabotype) clearly matches the biochemical pathways in which these enzymes are active. Our results suggest that common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population. This may lead to a novel approach to personalized health care based on a combination of genotyping and metabolic characterization. These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge.

  9. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

    Directory of Open Access Journals (Sweden)

    Christian Gieger

    2008-11-01

    Full Text Available The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the physiological state of the human body. Genetic variants that associate with changes in the homeostasis of key lipids, carbohydrates, or amino acids are not only expected to display much larger effect sizes due to their direct involvement in metabolite conversion modification, but should also provide access to the biochemical context of such variations, in particular when enzyme coding genes are concerned. To test this hypothesis, we conducted what is, to the best of our knowledge, the first GWA study with metabolomics based on the quantitative measurement of 363 metabolites in serum of 284 male participants of the KORA study. We found associations of frequent single nucleotide polymorphisms (SNPs with considerable differences in the metabolic homeostasis of the human body, explaining up to 12% of the observed variance. Using ratios of certain metabolite concentrations as a proxy for enzymatic activity, up to 28% of the variance can be explained (p-values 10(-16 to 10(-21. We identified four genetic variants in genes coding for enzymes (FADS1, LIPC, SCAD, MCAD where the corresponding metabolic phenotype (metabotype clearly matches the biochemical pathways in which these enzymes are active. Our results suggest that common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population. This may lead to a novel approach to personalized health care based on a combination of genotyping and metabolic characterization. These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge.

  10. The society for craniofacial genetics and developmental biology 38th annual meeting.

    Science.gov (United States)

    Taneyhill, Lisa A; Hoover-Fong, Julie; Lozanoff, Scott; Marcucio, Ralph; Richtsmeier, Joan T; Trainor, Paul A

    2016-07-01

    The mission of the Society for Craniofacial Genetics and Developmental Biology (SCGDB) is to promote education, research, and communication about normal and abnormal development of the tissues and organs of the head. The SCGDB welcomes as members undergraduate students, graduate students, post doctoral researchers, clinicians, orthodontists, scientists, and academicians who share an interest in craniofacial biology. Each year our members come together to share their novel findings, build upon, and challenge current knowledge of craniofacial biology. © 2016 Wiley Periodicals, Inc.

  11. Endogenous estradiol and risk of dementia in women and men : The Rotterdam Study

    NARCIS (Netherlands)

    Geerlings, MI; Launer, LJ; de Jong, FH; Ruitenberg, A; Stijnen, T; van Swieten, JC; Hofman, A; Witteman, JCM; Pols, HAP; Breteler, MMB

    2003-01-01

    We determined whether higher endogenous estradiol levels were associated with lower risk of dementia in older men and women not using hormonal replacement therapy, using a case-cohort design within the Rotterdam Study, a population-based follow-up study on chronic diseases, including dementia, in 7,

  12. Environmental impacts of international shipping. A case study of the port of Rotterdam

    Energy Technology Data Exchange (ETDEWEB)

    Den Boer, E.; Verbraak, G. [CE Delft, Delft (Netherlands)

    2010-02-01

    As part of the project 'Environmental Impacts of International Shipping: the role of ports' of the Working Group on Transport under OECD's Environment Policy Committee, CE Delft carried out this case study focusing on how the port of Rotterdam and the Dutch authorities address the environmental impacts of the port and its interactions with the hinterlands.

  13. Leader Firms: The value of companies for the competitiveness of the Rotterdam seaport cluster

    NARCIS (Netherlands)

    M.H. Nijdam (Michiel)

    2010-01-01

    textabstractThe port of Rotterdam is the largest seaport in Europe and a huge industrial complex. This seaport has been the focal point of several studies that merely view the port as a transport node. This neglects the fact that it is also a collection of thousands of related businesses that togeth

  14. Cataract surgery and the risk of aging macula disorder: The Rotterdam study

    NARCIS (Netherlands)

    L. Ho (Lintje); S. Boekhoorn (Sharmila); A. Liana (Alin); P. Tikka-Kleemola (Päivi); A.G. Uitterlinden (André); A. Hofman (Albert); P.T.V.M. de Jong (Paulus); Th. Stijnen (Theo); J.R. Vingerling (Hans)

    2008-01-01

    textabstractPURPOSE. To investigate still-controversial associations between prior cataract surgery and aging macula disorder (AMD) in a general population. METHODS. Baseline lens status and risk of incident AMD (iAMD) were examined in participants of the prospective population-based Rotterdam Study

  15. Risk of bilateral visual impairment in individuals with amblyopia: The Rotterdam study

    NARCIS (Netherlands)

    R. van Leeuwen (Redmer); M.J.C. Eijkemans (René); J.R. Vingerling (Hans); A. Hofman (Albert); P.T.V.M. de Jong (Paulus); H.J. Simonsz (Huib)

    2007-01-01

    textabstractBackground: The excess risk of bilateral visual impairment (BVI; bilateral visual acuity <0.5) among individuals with amblyopia is an argument for screening for amblyopia, but data are scarce. Methods: The risk was estimated by determining the incidence of BVI in the Rotterdam Study, a

  16. Numerical Modelling of Rain-Wind-Induced Vibration: Erasmus Bridge, Rotterdam

    NARCIS (Netherlands)

    Geurts, C.; Vrouwenvelder, T.; Staalduinen, P.C. van; Reusink, J.

    1998-01-01

    Shortly after completion, the main span cables of the Erasmus Bridge in Rotterdam showed aerodynamic instabilities with large amplitudes. These instabilities were recognised as rain-wind-induced vibrations. Temporary measures were installed on the bridge, and a year later, tuned hydraulic dampers we

  17. The monitoring programme for the Maasvlakte 2: Part I: Construction at the Port of Rotterdam (1)

    NARCIS (Netherlands)

    Borst, W.; Vellinga, T.

    2012-01-01

    Maasvlakte 2 (MV2) is the Port of Rotterdam Authority’s port extension project west of the existing Maasvlakte. The project area is 2,000 hectare gross of which 1,000 hectare is the net infrastructure. The first phase of the project is scheduled to be finished in mid-2013. Before operations for the

  18. Prevalence of heart failure and left ventricular dysfunction in the general population; The Rotterdam Study

    NARCIS (Netherlands)

    A. Mosterd (Arend); A.W. Hoes (Arno); M.C. de Bruyne (Martine); D.T. Linker (David); D.E. Grobbee (Diederick); J.W. Deckers (Jaap); A. Hofman (Albert)

    1999-01-01

    textabstractAIMS: To determine the prevalence of heart failure and symptomatic as well as asymptomatic left ventricular systolic dysfunction in the general population. METHODS AND RESULTS: In 5540 participants of the Rotterdam Study (age 68.9+/-8.7 years, 2251 men) aged

  19. Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study

    NARCIS (Netherlands)

    M.C. de Bruyne (Martine); A.W. Hoes (Arno); J.A. Kors (Jan); J.H. van Bemmel (Jan); D.E. Grobbee (Diederick); A. Hofman (Albert)

    1999-01-01

    textabstractAIMS: To examine the association between heart-rate corrected QT prolongation and cardiac and all-cause mortality in the population-based Rotterdam Study among men and women aged 55 years or older and to compare the prognostic value of the QT interval, using

  20. Landschapselementen ter verbetering van de luchtkwaliteit rond de Ruit van Rotterdam. Een haalbaarheidsstudie.

    NARCIS (Netherlands)

    Tonneijck, A.E.G.; Blom-Zandstra, M.

    2002-01-01

    Haalbaarheidsstudie naar het gebruik van landschapselementen als zuiveraars van lucht rond de Ruit van Rotterdam (ringweg die bestaat uit de A20, A15, A16 en de A4). Waarbij gelet op de soms extreme groeiomstandigheden in de restruimten. De aandacht is speciaal gericht op stikstofdioxiden (NO2) en

  1. The effects of the internal flow structure on SPM entrapment in the Rotterdam Waterway

    NARCIS (Netherlands)

    De Nijs, M.A.J.; Winterwerp, J.C.; Pietrzak, J.D.

    2010-01-01

    Field measurements are presented, which are the first to quantify the processes influencing the entrapment of suspended particulate matter (SPM) at the limit of saltwater intrusion in the Rotterdam Waterway. The estuarine turbidity maximum (ETM) is shown to be maintained by the trapping of fluvial S

  2. Is Diabetes Mellitus a Risk Factor for Open-Angle Glaucoma? The Rotterdam Study

    NARCIS (Netherlands)

    Voogd, S. de; Ikram, M.K.; Wolfs. R.C.W., [No Value; Jansonius, N.M.; Witteman, J.C.M.; Hofman, A.; de Jong, P.T.V.M.

    2006-01-01

    Purpose: To investigate whether diabetes mellitus is a risk factor for open-angle glaucoma (OAG). Design: Prospective population-based cohort study. Participants: Participants ages =55 years from the Rotterdam Study, The Netherlands. Methods: Participants at risk for incident OAG (iOAG) underwent at

  3. Student diversity at Erasmus Medical Centre Rotterdam: does it make any difference?

    NARCIS (Netherlands)

    Selleger, V.; Bonke, B.; Leeman, Y.A.M.

    2006-01-01

    In an ethnically diverse society cultural competence is indispensable for medical doctors. At present 10% of the Dutch population are first- or second-generation non-Western immigrants. With 8% Western and 18% non-Western immigrants, originating from 30 different countries, the 2001 Rotterdam first-

  4. Incidence of open-angle glaucoma in a general elderly population - The Rotterdam Study

    NARCIS (Netherlands)

    de Voogd, S; Ikram, MK; Wolfs, RCW; Jansonius, NM; Hofman, A; de Jong, PTVM

    2005-01-01

    Purpose: To determine the incidence of open-angle glaucoma (OAG) in a general elderly white population. Design: Population-based cohort study. Participants: Participants 55 years and older from the Rotterdam Study, The Netherlands. Methods: Participants at risk for incident OAG underwent at baseline

  5. Age, gender and disability predict future disability in older people: The Rotterdam Study

    NARCIS (Netherlands)

    U. Taş (Ümit); E.W. Steyerberg (Ewout); S.M. Bierma-Zeinstra (Sita); A. Hofman (Albert); B.W. Koes (Bart); A.P. Verhagen (Arianne)

    2011-01-01

    textabstractBackground: To develop a prediction model that predicts disability in community-dwelling older people. Insight in the predictors of disability is needed to target preventive strategies for people at increased risk. Methods. Data were obtained from the Rotterdam Study, including subjects

  6. Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population - The Rotterdam study

    NARCIS (Netherlands)

    Stolk, RP; Pols, HAP; Lamberts, SWJ; deJong, PTVM; Hofman, A; Grobbee, DE

    1997-01-01

    To estimate the prevalence of glucose intolerance in the elderly, oral glucose tolerance tests were performed as part of the Rotterdam Study, a population-based study in subjects aged 55 years and over, The study population consisted of 2,668 men and 3,950 women, Diabetes mellitus was defined as the

  7. Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study

    NARCIS (Netherlands)

    Praagman, J.; Franco, O.H.; Ikram, M.A.; Soedamah-Muthu, S.S.; Engberink, M.F.; Rooij, van F.J.A.; Hofman, A.; Geleijnse, J.M.

    2015-01-01

    Purpose We examined whether consumption of total dairy and dairy subgroups was related to incident stroke and coronary heart disease (CHD) in a general older Dutch population. Methods The study involved 4,235 participants of the Rotterdam Study aged 55 and over who were free of cardiovascular

  8. Spatial variability of the Rotterdam urban heat island as influenced by urban land use

    NARCIS (Netherlands)

    Heusinkveld, B.G.; Steeneveld, G.J.; Hove, van L.W.A.; Jacobs, C.M.J.; Holtslag, A.A.M.

    2014-01-01

    Novel bicycle traverse meteorological measurements were made in Rotterdam to assess the spatial variation of temperature during a tropical day. Nocturnal spatial urban temperature differences of 7¿K were found to be related to city morphology. The coolest residential areas were green low-density urb

  9. STDs and HIV infection in men who have sex with men: Rotterdam cohort study

    NARCIS (Netherlands)

    E.M. van der Snoek (Eric)

    2004-01-01

    textabstractA general introduction is presented in chapter 1. The Rotterdam cohort study (ROHOCO) took place from February 1999 to January 2002 at the sexually transmitted diseases (STDs) clinic of the department of Dermatology and Venereology of the Erasmus MC, University Medical Centre Rotterda

  10. Autokraak verminderd of verplaatst? : De effecten van een Rotterdams project tegen diefstal uit auto

    NARCIS (Netherlands)

    Hesseling, R.B.P.; Aron, U.

    1995-01-01

    In dit rapport wordt verslag gedaan van een empirisch onderzoek op het gebied van criminaliteitspreventie en verplaatsing. Centraal staat de vraag of de aanpak van diefstal uit auto's in het centrum van Rotterdam heeft geleid tot een verplaatsing van de criminaliteit naar andere wijken of delicten.

  11. Enkele hydrologische aspecten van een bodem- en grondwaterverontreiniging op het fabrieksterrein van Nestle te Rotterdam

    NARCIS (Netherlands)

    Mulschlegel; J.; Kusse; A.A.M.

    1984-01-01

    De Regionaal Inspecteur van de Volksgezondheid voor de Milieuhygiene voor Zuid-Holland verzocht RIVM-LBG inzicht te geven in de eventuele verbreiding van een verontreiniging op het fabrieksterrein van Nestle te Rotterdam. Bij het uitgevoerde onderzoek is gebruik gemaakt van een 3-dimensionaal gr

  12. The surface heat island of Rotterdam and its relationship with urban surface characteristics

    NARCIS (Netherlands)

    Klok, L.; Zwart, S.; Verhagen, H.; Mauri, E.

    2012-01-01

    Thermal infrared high resolution satellite images from Landsat sensors were used to spatially quantify the surface heat island (SHI) of Rotterdam in the Netherlands. Based on surface temperature maps retrieved on 15 summer days since 1984, the average surface temperature of each district and neighbo

  13. Een eerste inschatting van het Urban Heat Island effect voor Rotterdam en omgeving – een modelstudie

    NARCIS (Netherlands)

    Steeneveld, G.J.; Hove, van L.W.A.

    2010-01-01

    Tot nu toe is weinig bekend over het warmte-eiland effect in Nederland. Het doel van deze studie is om door middel van een modelstudie een eerste inschatting te maken van het warmte-eiland effect van de stad Rotterdam en naastgelegen omgeving, voor twee episodes in een hittegolf (in 2003, en 2006).

  14. A Local Dimension of Integration Policies? A Comparative Study of Berlin, Malmö, and Rotterdam

    NARCIS (Netherlands)

    R. Dekker (Rianne); H. Emilsson (Henrik); B. Krieger (Bernhard); P.W.A. Scholten (Peter)

    2015-01-01

    textabstractThis study examines three theses on local integration policies by a qualitative comparative case study of integration policies in three cities in three different countries (Berlin, Malmö, and Rotterdam). We found little evidence of a congruent local dimension of integration policies. Loc

  15. Serum carotenoids and cerebral white matter lesions : The Rotterdam Scan Study

    NARCIS (Netherlands)

    den Heijer, T; Launer, LJ; de Groot, JG; de Leeuw, FE; Oudkerk, M; van Gijn, J; Hofman, A; Breteler, MMB

    OBJECTIVES: To study the relation between serum levels of carotenoids and white matter lesions (WMLs) on magnetic resonance imaging (MRI). DESIGN: Evaluation of cross-sectional data from a cohort study. SETTING: The Rotterdam Scan Study. PARTICIPANTS: Two hundred and three nondemented older persons,

  16. New criteria for liver transplantation in adults : the combined Groningen and Rotterdam protocol

    NARCIS (Netherlands)

    Jansen, PLM

    1998-01-01

    A combined protocol for liver transplantation has been written by the teams of Groningen and Rotterdam. This is to ensure that the criteria for selection and timing of liver transplantation, and the procedures for patient evaluation, are identical or at least very similar. Also, the waiting list pro

  17. Evaluatie van de dioxine-emissies van de afvalverbrandingsinstallatie in Rotterdam

    NARCIS (Netherlands)

    Matthijsen AJCM; van Jaarsveld JA; de Jong APJM; Schutter MAA; Slob W; Theelen RMC; Vos JJ; Sein AA

    1991-01-01

    Emission measurements at the municipal solid waste incinerator (MSWI) ROTEB at Rotterdam show an average dioxin concentration in the stack gas of 92 ng TEQ/Nm3 (dry, 11% oxygen) when expressed in 2,3,7,8-TCDD toxicity equivalents (TEQ). This concentration is considered to be rather high for this ty

  18. Effects of bladdered fish on ambient noise measurements close to the port of Rotterdam

    NARCIS (Netherlands)

    Ainslie, M.A.; Jong C.A.F. de; Dreschler, J.

    2011-01-01

    Ambient noise in the frequency range 25 Hz to 80 kHz was measured at a site close to the Port of Rotterdam in September 2008, before construction began of a port extension known as ‘Maasvlakte 2’ [http://www.maasvlakte2.com/en/index/], and in September-October 2009 (during construction). Day-night

  19. Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study

    NARCIS (Netherlands)

    de Voogd, Simone; Ikram, M. Kamran; Wolfs, Roger C. W.; Jansonius, Nomdo M.; Witteman, Jacqueline C. M.; Hofman, Albert; de Jong, Paulus T. V. M.

    2006-01-01

    Purpose: To investigate whether diabetes mellitus is a risk factor for open-angle glaucoma (OAG). Design: Prospective population-based cohort study. Participants: Participants ages >= 55 years from the Rotterdam Study, The Netherlands. Methods: Participants at risk for incident OAG (iOAG) underwent

  20. Lifestyle and Risk of Developing Open-Angle Glaucoma The Rotterdam Study

    NARCIS (Netherlands)

    Ramdas, Wishal D.; Wolfs, Roger C. W.; Hofman, Albert; de Jong, Paulus T. V. M.; Vingerling, Johannes R.; Jansonius, Nomdo M.

    2011-01-01

    Objective: To determine whether lifestyle-related risk factors, such as socioeconomic status, smoking, alcohol consumption, and obesity, are associated with open-angle glaucoma (OAG). Methods: Participants from the Rotterdam Study, a prospective population-based cohort study, were considered eligibl

  1. Diagnostic value of the Rotterdam-CAMCOG in post-stroke dementia

    NARCIS (Netherlands)

    I. de Koning (Inge); F. van Kooten (Fop); P.J. Koudstaal (Peter Jan); D.W.J. Dippel (Diederik)

    2005-01-01

    textabstractBACKGROUND AND OBJECTIVE: Specific screening tests to detect post-stroke dementia are lacking. We recently reported that an adaptation of the Cambridge Cognitive Examination (CAMCOG), the Rotterdam-CAMCOG, had excellent sensitivity and specificity for detecting post-str

  2. Endogenous estradiol and risk of dementia in women and men : The Rotterdam Study

    NARCIS (Netherlands)

    Geerlings, MI; Launer, LJ; de Jong, FH; Ruitenberg, A; Stijnen, T; van Swieten, JC; Hofman, A; Witteman, JCM; Pols, HAP; Breteler, MMB

    We determined whether higher endogenous estradiol levels were associated with lower risk of dementia in older men and women not using hormonal replacement therapy, using a case-cohort design within the Rotterdam Study, a population-based follow-up study on chronic diseases, including dementia, in

  3. HIV-surveys bij hoog-risicogroepen in Rotterdam 2002-2003

    NARCIS (Netherlands)

    Veen MG van; Beuker RJ; Brito O de; Goetz H; Koster M de; Al Taqatqa W; Zwart O de; Laar MJW van de; CIE

    2005-01-01

    Er bestaat een potentieel risico op verspreiding van HIV en SOA vanuit hoog-risicogroepen naar de rest van de bevolking in Nederland. Dit blijkt uit de eerste HIV-survey die is uitgevoerd in Rotterdam. Hierbij is gevonden dat de HIV-prevalentie onder prostituees 7% is, onder injecterende druggeb

  4. HIV-surveys bij hoog-risicogroepen in Rotterdam 2002-2003

    NARCIS (Netherlands)

    Veen MG van; Beuker RJ; Brito O de; Goetz H; Koster M de; Al Taqatqa W; Zwart O de; Laar MJW van de; GGD Rotterdam e.o.; CIE

    2005-01-01

    There is a potential risk for further spread of HIV and STI from high risk groups into the general population in the Netherlands. These are the main conclusions of the first HIV survey among high risk groups in Rotterdam. Among commercial sex workers (CSW) the HIV prevalence is 7%, 10% among injecti

  5. Mortality and Life Expectancy in Homeless Men and Women in Rotterdam: 2001-2010

    NARCIS (Netherlands)

    W.J. Nusselder (Wilma); M.T. Slockers (Marcel); L. Krol (Luuk); C.T. Slockers (Colette); C.W.N. Looman (Caspar); E.F. van Beeck (Ed)

    2013-01-01

    textabstractBackground:Data on mortality among homeless people are limited. Therefore, this study aimed to describe mortality patterns within a cohort of homeless adults in Rotterdam (the Netherlands) and to assess excess mortality as compared to the general population in that city.Methods:Based on

  6. BONE-DENSITY IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS - THE ROTTERDAM STUDY

    NARCIS (Netherlands)

    VANDAELE, PLA; STOLK, RP; BURGER, H; ALGRA, D; GROBBEE, DE; HOFMAN, A; BIRKENHAGER, JC; POLS, HAP

    1995-01-01

    Objective: To investigate the relation between noninsulin-dependent diabetes mellitus and bone mineral density at the lumbar spine and hip. Design: Population-based study with a cross-sectional survey, Setting: A district of Rotterdam, the Netherlands. Participants: 5931 residents (2481 men, 3450

  7. Meeting report of the EC/US workshop on genetic risk assessment: "human genetic risks from exposure to chemicals, focusing on the feasibility of a parallelogram approach".

    Science.gov (United States)

    Waters, M D; Nolan, C

    1994-05-01

    This workshop was the concept of Professor Frits Sobels who passed away on the 6th of July 1993. The underlying idea of the Sobels' parallelogram approach is that an estimate (corrected by DNA-adduct dosimetry) of the genetic damage in human germ cells can be obtained by measuring a common endpoint in human and mouse somatic cells (such as gene mutation in lymphocytes) and in germ cells of mice, the desired target tissue inaccessible in humans. The main objective of the workshop was to identify the methodology, data requirements and mechanistic research to understand the human health impact of germ-cell mutagens. 4 chemicals were selected for review at the meeting: ethylene oxide, 1,3-butadiene, acrylamide and cyclophosphamide. The first 3 are important industrial chemicals with substantial use worldwide and, therefore, considerable potential human exposure. The 4th, cyclophosphamide, is a commonly used cancer chemotherapeutic agent. This first EC/US workshop on risk assessment was highly focused on the feasibility of the parallelogram concept to estimate potential germ-cell effects in humans. It represented an evaluation of current knowledge and the identification of future research needs for a more precise assessment of human genetic risks from exposure to mutagenic chemicals.

  8. Monster potential meets potential monster: pros and cons of deploying genetically modified microalgae for biofuels production.

    Science.gov (United States)

    Flynn, K J; Mitra, A; Greenwell, H C; Sui, J

    2013-02-06

    Biofuels production from microalgae attracts much attention but remains an unproven technology. We explore routes to enhance production through modifications to a range of generic microalgal physiological characteristics. Our analysis shows that biofuels production may be enhanced ca fivefold through genetic modification (GM) of factors affecting growth rate, respiration, photoacclimation, photosynthesis efficiency and the minimum cell quotas for nitrogen and phosphorous (N : C and P : C). However, simulations indicate that the ideal GM microalgae for commercial deployment could, on escape to the environment, become a harmful algal bloom species par excellence, with attendant risks to ecosystems and livelihoods. In large measure, this is because an organism able to produce carbohydrate and/or lipid at high rates, providing stock metabolites for biofuels production, will also be able to attain a stoichiometric composition that will be far from optimal as food for the support of zooplankton growth. This composition could suppress or even halt the grazing activity that would otherwise control the microalgal growth in nature. In consequence, we recommend that the genetic manipulation of microalgae, with inherent consequences on a scale comparable to geoengineering, should be considered under strict international regulation.

  9. Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations

    Science.gov (United States)

    Ganz, Ariel B.; Cohen, Vanessa V.; Swersky, Camille C.; Stover, Julie; Vitiello, Gerardo A.; Lovesky, Jessica; Chuang, Jasmine C.; Shields, Kelsey; Fomin, Vladislav G.; Lopez, Yusnier S.; Mohan, Sanjay; Ganti, Anita; Carrier, Bradley; Malysheva, Olga V.; Caudill, Marie A.

    2017-01-01

    Single nucleotide polymorphisms (SNPs) in choline metabolizing genes are associated with disease risk and greater susceptibility to organ dysfunction under conditions of dietary choline restriction. However, the underlying metabolic signatures of these variants are not well characterized and it is unknown whether genotypic differences persist at recommended choline intakes. Thus, we sought to determine if common genetic risk factors alter choline dynamics in pregnant, lactating, and non-pregnant women consuming choline intakes meeting and exceeding current recommendations. Women (n = 75) consumed 480 or 930 mg choline/day (22% as a metabolic tracer, choline-d9) for 10–12 weeks in a controlled feeding study. Genotyping was performed for eight variant SNPs and genetic differences in metabolic flux and partitioning of plasma choline metabolites were evaluated using stable isotope methodology. CHKA rs10791957, CHDH rs9001, CHDH rs12676, PEMT rs4646343, PEMT rs7946, FMO3 rs2266782, SLC44A1 rs7873937, and SLC44A1 rs3199966 altered the use of choline as a methyl donor; CHDH rs9001 and BHMT rs3733890 altered the partitioning of dietary choline between betaine and phosphatidylcholine synthesis via the cytidine diphosphate (CDP)-choline pathway; and CHKA rs10791957, CHDH rs12676, PEMT rs4646343, PEMT rs7946 and SLC44A1 rs7873937 altered the distribution of dietary choline between the CDP-choline and phosphatidylethanolamine N-methyltransferase (PEMT) denovo pathway. Such metabolic differences may contribute to disease pathogenesis and prognosis over the long-term. PMID:28134761

  10. Recommendations from a meeting on health implications of genetically modified organism (GMO).

    Science.gov (United States)

    Amofah, George

    2014-06-01

    The Ghana Public Health Association organized a scientific seminar to examine the introduction of genetically modified organisms into public use and the health consequences. The seminar was driven by current public debate on the subject. The seminar identified some of the advantages of GMOs and also the health concerns. It is clear that there is the need to enhance local capacity to research the introduction and use of GMOs; to put in place appropriate regulatory mechanisms including particularly the labeling of GMO products and post-marketing surveillance for possible negative health consequences in the long term. Furthermore the appropriate state agency should put in place advocacy strategies to keep the public informed about GMOs.

  11. Gene Editing and Genetic Lung Disease. Basic Research Meets Therapeutic Application.

    Science.gov (United States)

    Alapati, Deepthi; Morrisey, Edward E

    2017-03-01

    Although our understanding of the genetics and pathology of congenital lung diseases such as surfactant protein deficiency, cystic fibrosis, and alpha-1 antitrypsin deficiency is extensive, treatment options are lacking. Because the lung is a barrier organ in direct communication with the external environment, targeted delivery of gene corrective technologies to the respiratory system via intratracheal or intranasal routes is an attractive option for therapy. CRISPR/Cas9 gene-editing technology is a promising approach to repairing or inactivating disease-causing mutations. Recent reports have provided proof of concept by using CRISPR/Cas9 to successfully repair or inactivate mutations in animal models of monogenic human diseases. Potential pulmonary applications of CRISPR/Cas9 gene editing include gene correction of monogenic diseases in pre- or postnatal lungs and ex vivo gene editing of patient-specific airway stem cells followed by autologous cell transplant. Strategies to enhance gene-editing efficiency and eliminate off-target effects by targeting pulmonary stem/progenitor cells and the assessment of short-term and long-term effects of gene editing are important considerations as the field advances. If methods continue to advance rapidly, CRISPR/Cas9-mediated gene editing may provide a novel opportunity to correct monogenic diseases of the respiratory system.

  12. Outline for the Rotterdam Climate Initiative. CO2 emissions up to 2030; Verkenning voor Rotterdam Climate Initiative. CO2-emissies tot 2030

    Energy Technology Data Exchange (ETDEWEB)

    Plomp, A.J.; Wetzels, W.; Seebregts, A.J.; Kroon, P [ECN Beleidsstudies, Petten (Netherlands)

    2013-04-15

    The Rotterdam Climate Initiative (RCI) aims to reduce the CO2 emissions within the city and port of Rotterdam by 50% in 2025 as compared to 1990. This target translates into a total emission of 12 Mton of CO2. In this study, Rotterdam's CO2 emissions have been estimated for the future years 2015, 2020, 2025 and 2030 based on autonomous developments combined with a policy framework that is assumed to be fixed. This study only explores the sectors Energy and Industry and Freight transport within Rotterdam. The results demonstrate that: (a) CO2 emissions resulting from the sector Energy and Industry increase from 26.5 Mton CO2 in 2011 to 33.8 Mton CO2 in 2020, and slightly decrease afterwards to 29.4 Mton CO2 in 2025 and 2030; and (b) CO2 emissions resulting from Freight transport increase from 1.0 Mton CO2 in 2011 to 1.4 Mton CO2 in 2025 and increase further to 1.6 Mton in 2030. This means that these sectors alone already exceed the emission target, and that substantial additional effort will be needed to attain the 50% CO2 reduction target. The estimated CO2 emissions are lower than those reported in the previous study that was published in 2010. Differences are mainly due to lower CO2 emissions from power plants as compared to the study in 2010. These are influenced by many different developments, such as high gas prices, low electricity prices and low CO2 prices. These estimates have been calculated bottom-up as much as possible and with the help of sector models. The realisation of Maasvlakte 2 has been taken into account in these results, which means more space for chemical plants and substantially more freight transfer and transport in Rotterdam [Dutch] Het Rotterdam Climate Initiative (RCI) heeft als doel om de CO2-emissie van de gemeente Rotterdam, inclusief de haven, in 2025 met 50% te reduceren ten opzichte van het basisjaar 1990. Deze doelstelling betekent een emissieniveau van 12 Mton CO2 in 2025 binnen de gemeente Rotterdam. In deze studie is de CO2

  13. Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study.

    Science.gov (United States)

    Kardys, Isabella; Uitterlinden, André G; Hofman, Albert; Witteman, Jacqueline C M; de Maat, Moniek P M

    2007-02-01

    Fibrin network structure has been correlated with coronary disease. Fibrinogen gamma and alpha (FGG and FGA) gene haplotypes (chromosome 4q28) may be associated with fibrin network structure, and thereby with rigidity of the fibrin clot and sensitivity of the fibrin clot to the fibrinolytic system. Through these mechanisms they may influence risk of cardiovascular disease. We set out to investigate the relation between combined fibrinogen FGG and FGA gene haplotypes, representing the common variation of the fibrinogen FGG and FGA genes, coronary events and measures of coronary and extracoronary atherosclerosis. The study was embedded in the Rotterdam Study, a prospective population-based study among men and women aged >or=55 years. Common haplotypes were studied using seven tagging SNPs across a 30-kb region with the FGG and FGA genes. Incident coronary events were registered, and carotid intima-media thickness, carotid plaques, ankle-arm index, aortic calcification and coronary calcification were assessed. Seven haplotypes with frequencies >1% covered 97.5% of the genetic variation. In 5,667 participants without history of coronary heart disease (CHD), 733 CHD cases occurred during a median follow-up time of 11.9 years. Fibrinogen gene haplotypes were not associated with coronary events. Fibrinogen gene haplotypes did not show a consistent association with measures of coronary and extracoronary atherosclerosis. In conclusion, fibrinogen FGG and FGA gene haplotypes are not associated with coronary events, coronary atherosclerosis or extracoronary atherosclerosis. Confirmation of these findings by future population-based studies is warranted.

  14. Environmental Compensation for Port Extension: The Case of Rotterdam Harbor and Nature Compensation, Policy and Practice

    Directory of Open Access Journals (Sweden)

    Frank van der Meulen

    2016-12-01

    Full Text Available The port of Rotterdam (the Netherlands recently built a large extension, Maasvlakte 2. It was built in an area with valuable coastal ecosystems belonging to the EU Natura 2000 network of European conservation areas. The construction and use of Maasvlakte 2 causes considerable damage to existing Natura 2000 sites. According to EU regulations this damage should be compensated by creating new nature. In the case of Rotterdam, the compensation was twofold: a marine and a terrestrial part. The paper describes the design and the actual lay-out of the compensation works. It also reports on the monitoring that is ongoing to assess the damage to existing nature and the quality of the new (compensated nature.

  15. A Modelling Approach for Integrated Planning of Port Capacity- Trade-Offs in Rotterdam Investment Planning

    Directory of Open Access Journals (Sweden)

    Sander Dekker

    2006-03-01

    Full Text Available This paper presents a modelling approach for planning ofport capacity. The approach integrates port commercial andpublic interests. It further incorporates route competition andautonomous demand growth. It is applied to port expansion,which can be considered as a strategy for an individual port todeal with route competition. The basis for solving this planningproblem comprises an analysis of port demand and supply in apartial equilibrium model. With such an approach, the reactionof a single port on the change in a transport network comprisingalternative routes to a hinterland destination can be simulated.To establish the optimal expansion strategy, port expansion iscombined with congestion pricing. This is used for the simultaneousdetermination of 1 optimal expansion size, and 2 investmentrecovery period. The modelling approach will be appliedto Rotterdam port focusing on port expansion by means ofland reclamation. The scenmio of the entry of a new competingroute via the Italian port Gioia Tauro is used to address sometrade-offs in Rotterdam investment planning.

  16. Genetic Counseling

    Science.gov (United States)

    Genetic counseling provides information and support to people who have, or may be at risk for, genetic disorders. A ... meets with you to discuss genetic risks. The counseling may be for yourself or a family member. ...

  17. Socioeconomic differences in stroke among Dutch elderly women: the Rotterdam Study

    OpenAIRE

    Rossum, Caroline; van de Mheen, Dike; Breteler, Monique; Grobbee, Diederick; Mackenbach, Johan

    1999-01-01

    textabstractBACKGROUND AND PURPOSE: We sought to assess the association between socioeconomic status and the risk of stroke among elderly women. Methods--The association between socioeconomic status and stroke emerged in cross-sectional and longitudinal data on 4274 female participants of the Rotterdam Study, a prospective, population-based, follow-up study in the Netherlands among older subjects. RESULTS: A history of stroke was more common among women in lower socioeconomic strata. The same...

  18. Improving Navigation information for the Rotterdam Harbour access through a 3D Model and HF radar

    Science.gov (United States)

    Schroevers, Marinus

    2015-04-01

    The Port of Rotterdam is one of the largest harbours in the world and a gateway to Europe. For the access to Rotterdam harbour, information on hydrodynamic and meteorological conditions is of vital importance for safe and swift navigation. This information focuses on the deep navigation channel in the shallow foreshore, which accommodates large seagoing vessels. Due to a large seaward extension of the Port of Rotterdam area in 2011, current patterns have changed. A re-evaluation of the information needed, showed a need for an improved accuracy of the cross channel currents and swell, and an extended forecast horizon. To obtain this, new information system was designed based on a three dimensional hydrodynamic model which produces a 72 hour forecast. Furthermore, the system will assimilate HF radars surface current to optimize the short term forecast. The project has started in 2013 by specifying data needed from the HF radar. At the same time (temporary) buoys were deployed to monitor vertical current profiles. The HF radar will be operational in July 2015, while the model development starts beginning 2015. A pre operational version of the system is presently planned for the end of 2016. A full operational version which assimilates the HF radar data is planned for 2017.

  19. Genetics

    Science.gov (United States)

    ... Inheritance; Heterozygous; Inheritance patterns; Heredity and disease; Heritable; Genetic markers ... The chromosomes are made up of strands of genetic information called DNA. Each chromosome contains sections of ...

  20. Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015.

    Science.gov (United States)

    Zai, Gwyneth; Alberry, Bonnie; Arloth, Janine; Bánlaki, Zsófia; Bares, Cristina; Boot, Erik; Camilo, Caroline; Chadha, Kartikay; Chen, Qi; Cole, Christopher B; Cost, Katherine T; Crow, Megan; Ekpor, Ibene; Fischer, Sascha B; Flatau, Laura; Gagliano, Sarah; Kirli, Umut; Kukshal, Prachi; Labrie, Viviane; Lang, Maren; Lett, Tristram A; Maffioletti, Elisabetta; Maier, Robert; Mihaljevic, Marina; Mittal, Kirti; Monson, Eric T; O'Brien, Niamh L; Østergaard, Søren D; Ovenden, Ellen; Patel, Sejal; Peterson, Roseann E; Pouget, Jennie G; Rovaris, Diego L; Seaman, Lauren; Shankarappa, Bhagya; Tsetsos, Fotis; Vereczkei, Andrea; Wang, Chenyao; Xulu, Khethelo; Yuen, Ryan K C; Zhao, Jingjing; Zai, Clement C; Kennedy, James L

    2016-12-01

    The XXIIIrd World Congress of Psychiatric Genetics meeting, sponsored by the International Society of Psychiatric Genetics, was held in Toronto, ON, Canada, on 16-20 October 2015. Approximately 700 participants attended to discuss the latest state-of-the-art findings in this rapidly advancing and evolving field. The following report was written by trainee travel awardees. Each was assigned one session as a rapporteur. This manuscript represents the highlights and topics that were covered in the plenary sessions, symposia, and oral sessions during the conference, and contains major notable and new findings.

  1. Determinants of primary open-angle glaucoma : a genetic-epidemiologic approach

    NARCIS (Netherlands)

    C.A.A. Hulsman

    2002-01-01

    textabstractIn the first part of this thesis, potential environmental and genetic risk factors for POAG are examined in the Rotterdam Study, a prospective population-based cohort study among subjects 55 years and older. In its second part, the population of a genetic isolate is investigated, using a

  2. Line and Form: linear, areal, inclusive and accessible public spaces. Hoofbogen in Rotterdam

    Directory of Open Access Journals (Sweden)

    Maurizio Francesco Errigo

    2013-06-01

    Full Text Available In the contemporary city places more and more lose their character of physical stock and became space of flow; the city isn’t characterized by its immobile uniqueness, but is modified and reassembled at the rate of circulation in it comes to life. Today the city is presented as a set of discontinuous fragments, which return an image of plural spaces, places and non-places, past and present. Disappearing borders, perimeters, which marked the places, neighborhoods are uncommon spaces, undefined areas between built and unbuilt. The square is the gap in the building density; it has lost its significance as a place of socialization. The recent planning instruments (plans and programs that belong to the city of Rotterdam are geared to transform the city into a “child-friendly city" (city suitable for children, the city attracts young couples and middle-class families just for the fact that the city is distancing itself from the modernist planning based on the zoning and is encouraging the mix of urban functions; particular emphasis in this phase of planning and urban design is given by the statement of the urban Vision Rotterdam 2030. The case dealt with in the article is related to the area of ​​Bergpolder, in the north of Rotterdam, an area affected by a strong identity disposed element, a railway viaduct, and is characterized by a strong strategic value for the location and proximity with the urban center and is affected by both social and economic problem due to the insufficiency of public spaces, the use of spaces and public facilities, to the social mixité, characterized by the mixture of different ethnic groups.

  3. Assessing public leadership styles for innovation: A comparison of Copenhagen, Rotterdam and Barcelona

    DEFF Research Database (Denmark)

    Ricard, Lykke Margot; Klijn, Erik Hans; Lewis, Jenny M.

    2016-01-01

    of these proved to be more robust than others. Analysis of the three cities reveals a nuanced set of leadership styles, which include a transformational style, and one that is more dedicated to motivating employees, risk-taking and including others in decision-making. This suggests the need for more research......This article explores which leadership qualities public managers regard as important for public innovation. It is based on a survey of 365 senior public managers in Copenhagen, Rotterdam and Barcelona. Five perspectives on leadership were identified and tested using a number of items. Some...... on leadership and public-sector innovation....

  4. Assessing public leadership styles for innovation: A comparison of Copenhagen, Rotterdam and Barcelona

    DEFF Research Database (Denmark)

    Ricard, Lykke Margot; Lewis, Jenny M; Klijn, Erik Hans

    2017-01-01

    of these proved to be more robust than others. Analysis of the three cities reveals a nuanced set of leadership styles, which include a transformational style, and one that is more dedicated to motivating employees, risk-taking and including others in decision-making. This suggests the need for more research......This article explores which leadership qualities public managers regard as important for public innovation. It is based on a survey of 365 senior public managers in Copenhagen, Rotterdam and Barcelona. Five perspectives on leadership were identified and tested using a number of items. Some...... on leadership and public-sector innovation...

  5. Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study.

    Science.gov (United States)

    Darweesh, Sirwan K L; Leening, Maarten J G; Akoudad, Saloua; Loth, Daan W; Hofman, Albert; Ikram, M Arfan; Vernooij, Meike W; Stricker, Bruno H

    2013-09-26

    Although clopidogrel reduces the incidence of atherothrombotic events, its use is associated with an increased risk of major bleeding. Cerebral microbleeds (CMBs) are indicative of subclinical microangiopathy in the brain and may prelude symptomatic intracerebral hemorrhage. We examined the association between use of clopidogrel and CMBs in persons without a history of stroke. We performed a cross-sectional analysis using data from the Rotterdam Study, a prospective population-based cohort of persons aged 45 years and older. Among 4408 stroke-free individuals who underwent brain magnetic resonance imaging for the detection of CMBs, we identified 121 ever-users and 4287 never-users of clopidogrel before magnetic resonance imaging. We used multiple logistic regression to analyze the association between clopidogrel and CMBs with adjustment for age, sex, cardiovascular risk factors, and common cardiovascular medication. Users of clopidogrel had a higher prevalence of CMBs (odd ratio 1.55, 95% CI 1.01 to 2.37) than nonusers and more often had a high number (> 4) of CMBs (odds ratio 3.19, 95% CI 1.52 to 6.72). Clopidogrel use was associated with a significantly higher prevalence of deep or infratentorial CMBs (odd ratio 1.90, 95% CI 1.05 to 3.45). Among clopidogrel users, we were unable to demonstrate differences in the prevalence of CMBs by indication of prescription, history of coronary heart disease, or common genetic variants in CYP2C19. In stroke-free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs. Whether this association is causal requires confirmation in prospective studies, especially given the small number of participants taking clopidogrel and the possibility of residual confounding in this study.

  6. Clopidogrel Use Is Associated With an Increased Prevalence of Cerebral Microbleeds in a Stroke‐Free Population: The Rotterdam Study

    Science.gov (United States)

    Darweesh, Sirwan K.L.; Leening, Maarten J.G.; Akoudad, Saloua; Loth, Daan W.; Hofman, Albert; Arfan Ikram, M.; Vernooij, Meike W.; Stricker, Bruno H.

    2013-01-01

    Background Although clopidogrel reduces the incidence of atherothrombotic events, its use is associated with an increased risk of major bleeding. Cerebral microbleeds (CMBs) are indicative of subclinical microangiopathy in the brain and may prelude symptomatic intracerebral hemorrhage. We examined the association between use of clopidogrel and CMBs in persons without a history of stroke. Methods and Results We performed a cross‐sectional analysis using data from the Rotterdam Study, a prospective population‐based cohort of persons aged 45 years and older. Among 4408 stroke‐free individuals who underwent brain magnetic resonance imaging for the detection of CMBs, we identified 121 ever‐users and 4287 never‐users of clopidogrel before magnetic resonance imaging. We used multiple logistic regression to analyze the association between clopidogrel and CMBs with adjustment for age, sex, cardiovascular risk factors, and common cardiovascular medication. Users of clopidogrel had a higher prevalence of CMBs (odd ratio 1.55, 95% CI 1.01 to 2.37) than nonusers and more often had a high number (>4) of CMBs (odds ratio 3.19, 95% CI 1.52 to 6.72). Clopidogrel use was associated with a significantly higher prevalence of deep or infratentorial CMBs (odd ratio 1.90, 95% CI 1.05 to 3.45). Among clopidogrel users, we were unable to demonstrate differences in the prevalence of CMBs by indication of prescription, history of coronary heart disease, or common genetic variants in CYP2C19. Conclusions In stroke‐free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs. Whether this association is causal requires confirmation in prospective studies, especially given the small number of participants taking clopidogrel and the possibility of residual confounding in this study. PMID:24072532

  7. A very large proportion of young Danish women have polycystic ovaries: is a revision of the Rotterdam criteria needed?

    DEFF Research Database (Denmark)

    Kristensen, Susanne Lund; Ramlau-Hansen, Cecilia; Ernst, Erik

    2010-01-01

    According to the Rotterdam 2003 criteria, an ovary is defined as polycystic if 12 or more follicles of 2-9 mm are present, when evaluating the ovary by ultrasonography on Days 3-5 of the menstrual cycle in women not using hormonal contraceptives. The aim of this population-based study was to esti......According to the Rotterdam 2003 criteria, an ovary is defined as polycystic if 12 or more follicles of 2-9 mm are present, when evaluating the ovary by ultrasonography on Days 3-5 of the menstrual cycle in women not using hormonal contraceptives. The aim of this population-based study...

  8. An everlasting role of genetics and genomics in public health: a meeting report of ACGA-HKSMG International Conference on Genetic and Genomic Medicine 2008

    Institute of Scientific and Technical Information of China (English)

    Wai-Yee Chan; Stephen T.S.Lam; Bai-Lin Wu

    2009-01-01

    @@ The Association of Chinese Geneticists in America (ACGA) and the Hong Kong Society of Medical Genetics (HKSMG) held their first joint Conference on Genetic and Genomic Medicine in Hong Kong from June 9-11 in 2008at the Cheung Kung Hai Conference Center, William MW Mong Block, Li Ka Shing Faculty of Medicine, the University of Hong Kong.

  9. Spatial variability of the Rotterdam urban heat island as influenced by urban land use

    Science.gov (United States)

    Heusinkveld, Bert G.; Steeneveld, G. J.; Hove, L. W. A.; Jacobs, C. M. J.; Holtslag, A. A. M.

    2014-01-01

    Novel bicycle traverse meteorological measurements were made in Rotterdam to assess the spatial variation of temperature during a tropical day. Nocturnal spatial urban temperature differences of 7 K were found to be related to city morphology. During midday measurements, the downtown was up to 1.2 K warmer than the surrounding rural area while a city park was 4.0 K cooler than downtown. A regression analysis showed that the nocturnal measured urban heat island (UHI) can be linked to land use, namely vegetation, built-up area, and water and is most significant for vegetation. From the traverse observation data, a multiple linear regression model was constructed and independently validated with 3 year summertime UHI statistics derived from four urban fixed meteorological stations and two fixed rural stations. Wind rose analysis shows that UHI is strongest from easterly directions and that the temperature signal of the WMO station is influenced from urban directions. A regression model reproduced the nighttime spatial variability of the UHI within a fractional bias of 4.3% and was used to derive an UHI map of Rotterdam and surroundings. This map shows that high-density urban configurations lacking greenery or close to large water bodies are vulnerable to high nocturnal temperatures during heat waves. The UHI map can be used as a valuable planning tool for mitigating nocturnal urban heat stress or identifying neighborhoods at risk during heat waves.

  10. Contributing Determinants to Hearing Loss in Elderly Men and Women: Results from the Population-Based Rotterdam Study

    NARCIS (Netherlands)

    S.C. Rigters (Stephanie); M. Metselaar (M.); Wieringa, M.H. (Marjan H.); De Jong, R.J.B. (Robert J. Baatenburg); A. Hofman (Albert); A. Goedegebure (Andre)

    2016-01-01

    textabstractTo contribute to a better understanding of the etiology in age-related hearing loss, we carried out a cross-sectional study of 3,315 participants (aged 52-99 years) in the Rotterdam Study, to analyze both low- and high-frequency hearing loss in men and women. Hearing thresholds with

  11. The Port of Rotterdam and the maritime container: The rise and fall of Rotterdam’s hinterland (1966-2010)

    NARCIS (Netherlands)

    K.M. Paardenkooper-Suli (Klara)

    2014-01-01

    markdownabstractThe research presented in this work explores the importance of containerization to the economic links within the Lower Rhine region, which is a transnational economic region consisting of the Rotterdam and Ruhr areas and some other parts of North Rhine Westphalia. The economic

  12. Le Medi: mediterraan gevoel te koop in Rotterdam: over de aantrekkingskracht van gethematiseerde woningbouw voor de nieuwe stedelijke middenklasse

    NARCIS (Netherlands)

    Meier, S.

    2009-01-01

    ‘Le medi’: buying a mediterranean feeling in Rotterdam Urban renewal of low-income neighbourhoods is frequently accompanied by branding of neighbourhoods. Planners aim to attract the middle-class by developing new housing which is theme oriented. The theming of the new housing combines an eye-catchi

  13. Complexity in Decision Making: The Case of the Rotterdam Harbour Expansion : Connecting Decisions, Arenas and Actors in Spatial Decision Making

    NARCIS (Netherlands)

    E-H. Klijn (Erik-Hans); M.K.A. van Gils (Marcel)

    2007-01-01

    textabstractDecision making about spatial projects is very complex. Decisions to develop the Rotterdam harbour are taken in the context of a network of local, regional, national, European and international actors, both public and private. These decision-making processes exhibit a lot of complexity a

  14. Incidence of Glaucomatous Visual Field Loss : A Ten-Year Follow-up from the Rotterdam Study

    NARCIS (Netherlands)

    Czudowska, Monika A.; Ramdas, Wishal D.; Wolfs, Roger C. W.; Hofman, Albert; De Jong, Paulus T. V. M.; Vingerling, Johannes R.; Jansonius, Nomdo M.

    2010-01-01

    Purpose: To determine the 10-year incidence of glaucomatous visual field loss (GVFL) and to investigate the influence of risk factors for open-angle glaucoma on this incidence. Design: Population-based cohort study. Participants: Participants aged >55 years from the Rotterdam Study. Methods: Of the

  15. Incidence of Glaucomatous Visual Field Loss: A Ten-Year Follow-up from the Rotterdam Study

    NARCIS (Netherlands)

    M.A. Czudowska; W.D. Ramdas; R.C.W. Wolfs; A. Hofman; P.T.V.M. de Jong; J.R. Vingerling; N.M. Jansonius

    2010-01-01

    Purpose: To determine the 10-year incidence of glaucomatous visual field loss (GVFL) and to investigate the influence of risk factors for open-angle glaucoma on this incidence. Design: Population-based cohort study. Participants: Participants aged >55 years from the Rotterdam Study. Methods: Of the

  16. Le Medi: mediterraan gevoel te koop in Rotterdam: over de aantrekkingskracht van gethematiseerde woningbouw voor de nieuwe stedelijke middenklasse

    NARCIS (Netherlands)

    Meier, S.

    2009-01-01

    ‘Le medi’: buying a mediterranean feeling in Rotterdam Urban renewal of low-income neighbourhoods is frequently accompanied by branding of neighbourhoods. Planners aim to attract the middle-class by developing new housing which is theme oriented. The theming of the new housing combines an eye-catchi

  17. Integration in urban climate adaptation: Lessons from Rotterdam on integration between scientific disciplines and integration between scientific and stakeholder knowledge

    NARCIS (Netherlands)

    Groot, A.M.E.; Bosch, P.R.; Buijs, S.; Jacobs, C.M.J.; Moors, E.J.

    2015-01-01

    Based on the experience acquired in the Bergpolder Zuid district in the city of Rotterdam, The Netherlands, this paper presents lessons learned so far on science-policy interactions supporting the adaptation to climate change in an urban district. Two types of integration issues were considered: (1)

  18. PCOS according to the Rotterdam consensus criteria : change in prevalence among WHO-II anovulation and association with metabolic factors

    NARCIS (Netherlands)

    Broekmans, F. J.; Knauff, E. A. H.; Valkenburg, O.; Laven, J. S.; Eijkemans, M. J.; Fauser, B. C. J. M.

    2006-01-01

    Objective The current report aims to compare the prevalence of polycystic ovary syndrome (PCOS) diagnosed according to the new Rotterdam criteria (Rott-PCOS) versus the previous criteria as formulated by the National Institutes of Health (NIH) (NIH-PCOS) in women with normogonadotropic (WHO-II) anov

  19. Supporting art cinema at a time of commercialization: Principles and practices, the case of the International Film Festival Rotterdam

    NARCIS (Netherlands)

    de Valck, M.

    2014-01-01

    This article examines how social agents negotiate the tension between an art for art's sake ideology and a commercializing subfield—using the specific case of the International Film Festival Rotterdam (IFFR). Drawing on Bourdieu's sociology of the arts and recent film festival studies, I discuss bot

  20. Next-generation sequencing meets genetic diagnostics: development of a comprehensive workflow for the analysis of BRCA1 and BRCA2 genes

    Science.gov (United States)

    Feliubadaló, Lídia; Lopez-Doriga, Adriana; Castellsagué, Ester; del Valle, Jesús; Menéndez, Mireia; Tornero, Eva; Montes, Eva; Cuesta, Raquel; Gómez, Carolina; Campos, Olga; Pineda, Marta; González, Sara; Moreno, Victor; Brunet, Joan; Blanco, Ignacio; Serra, Eduard; Capellá, Gabriel; Lázaro, Conxi

    2013-01-01

    Next-generation sequencing (NGS) is changing genetic diagnosis due to its huge sequencing capacity and cost-effectiveness. The aim of this study was to develop an NGS-based workflow for routine diagnostics for hereditary breast and ovarian cancer syndrome (HBOCS), to improve genetic testing for BRCA1 and BRCA2. A NGS-based workflow was designed using BRCA MASTR kit amplicon libraries followed by GS Junior pyrosequencing. Data analysis combined Variant Identification Pipeline freely available software and ad hoc R scripts, including a cascade of filters to generate coverage and variant calling reports. A BRCA homopolymer assay was performed in parallel. A research scheme was designed in two parts. A Training Set of 28 DNA samples containing 23 unique pathogenic mutations and 213 other variants (33 unique) was used. The workflow was validated in a set of 14 samples from HBOCS families in parallel with the current diagnostic workflow (Validation Set). The NGS-based workflow developed permitted the identification of all pathogenic mutations and genetic variants, including those located in or close to homopolymers. The use of NGS for detecting copy-number alterations was also investigated. The workflow meets the sensitivity and specificity requirements for the genetic diagnosis of HBOCS and improves on the cost-effectiveness of current approaches. PMID:23249957

  1. External validation of the rotterdam computed tomography score in the prediction of mortality in severe traumatic brain injury

    Directory of Open Access Journals (Sweden)

    Jose D Charry

    2017-01-01

    Full Text Available Introduction: Traumatic brain injury (TBI is a public health problem. It is a pathology that causes significant mortality and disability in Colombia. Different calculators and prognostic models have been developed to predict the neurological outcomes of these patients. The Rotterdam computed tomography (CT score was developed for prognostic purposes in TBI. We aimed to examine the accuracy of the prognostic discrimination and prediction of mortality of the Rotterdam CT score in a cohort of trauma patients with severe TBI in a university hospital in Colombia. Materials and Methods: We analyzed 127 patients with severe TBI treated in a regional trauma center in Colombia over a 2-year period. Bivariate and multivariate analyses were used. The discriminatory power of the score, its accuracy, and precision were assessed by logistic regression and as the area under the receiver operating characteristic curve. Shapiro–Wilk, Chi-square, and Wilcoxon tests were used to compare the real outcomes in the cohort against the predicted outcomes. Results: The median age of the patient cohort was 33 years, and 84.25% were male. The median injury severity score was 25, the median Glasgow Coma Scale motor score was 3, the basal cisterns were closed in 46.46% of the patients, and a midline shift of >5 mm was seen in 50.39%. The 6-month mortality was 29.13%, and the Rotterdam CT score predicted a mortality of 26% (P < 0.0001 (area under the curve: 0.825; 95% confidence interval: 0.745–0.903. Conclusions: The Rotterdam CT score predicted mortality at 6 months in patients with severe head trauma in a university hospital in Colombia. The Rotterdam CT score is useful for predicting early death and the prognosis of patients with TBI.

  2. 75 FR 62406 - Plan To Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting...

    Science.gov (United States)

    2010-10-08

    ... November 12, 2010. Contacts: For questions about the meeting logistics, please contact Ms. Nicole Numbers... address the questions below. If time permits, discussion of additional issues will be accommodated. 1. Based on an analysis of RFI comments and other operational issues, NIH is considering a phased approach...

  3. Testing time for deep water[Deep water test facility in Rotterdam, NL

    Energy Technology Data Exchange (ETDEWEB)

    Snieckus, Darius

    2000-06-01

    A new deep water test facility in Rotterdam in the Netherlands is described. The construction is a basin measuring 45m by 36m and some 10.5m deep: it can accommodate large scale model tests at depths equivalent to 1000m by using a hydraulic 'moveable' floor buoyed by syntactic foam. For simulation of depths of 3000m it opens its 'deep pit' - a well 5m diameter and 20m deep. The facility can also simulate the winds, waves and currents met offshore in places such as the Shetlands, West Africa and the Gulf of Mexico. The article includes pictures and diagrams of the facility.

  4. When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection.

    Science.gov (United States)

    Pacis, Alain; Nédélec, Yohann; Barreiro, Luis B

    2014-08-01

    The response of host immune cells to microbial stimuli is dependent on robust and coordinated gene expression programs involving the transcription of thousands of genes. The dysregulation of such regulatory programs is likely to significantly contribute to the marked differences in susceptibility to infectious diseases observed among individuals and between human populations. Although the specific factors leading to a dysfunctional immune response to infection remain largely unknown, we are increasingly appreciating the importance of genetic variants in altering the expression levels of immune-related genes, possibly via epigenetic changes. This review describes how recent technological advances have profoundly contributed to our current understanding of the genetic architecture and the epigenetic rules controlling immune responses to infectious agents and how genetic and epigenetic data can be combined to unravel the mechanisms associated with host variation in transcriptional responses to infection.

  5. REVIEW: Quantifying urban ecosystem services based on high‐resolution data of urban green space: an assessment for Rotterdam, the Netherlands

    National Research Council Canada - National Science Library

    Derkzen, Marthe L; Teeffelen, Astrid J. A; Verburg, Peter H; Diamond, Sarah

    2015-01-01

    .... This study derives methods to quantify and map a bundle of six ES as supplied by UGS , using land cover data with high spatial and thematic resolution, and applies these to the city of Rotterdam, the Netherlands...

  6. SIRT1 genetic variation is related to BMI and risk of obesity

    NARCIS (Netherlands)

    M.C. Zillikens (Carola); J.B.J. van Meurs (Joyce); F. Rivadeneira Ramirez (Fernando); N. Amin (Najaf); A. Hofman (Albert); B.A. Oostra (Ben); E.J.G. Sijbrands (Eric); J.C.M. Witteman (Jacqueline); H.A.P. Pols (Huib); P. Tikka-Kleemola (Päivi); A.G. Uitterlinden (André)

    2009-01-01

    textabstractOBJECTIVE - SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity. RESEARCH DESIGN AND METHODS - In 6,251 elderly subjects from the prospective, population-based Rotterdam Study, three single nucleotide polymorphisms (SNPs)

  7. Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index

    NARCIS (Netherlands)

    M.C. Zillikens (Carola); J.B.J. van Meurs (Joyce); F. Rivadeneira Ramirez (Fernando); A. Hofman (Albert); B.A. Oostra (Ben); E.J.G. Sijbrands (Eric); J.C.M. Witteman (Jacqueline); H.A.P. Pols (Huib); P. Tikka-Kleemola (Päivi); A.G. Uitterlinden (André)

    2010-01-01

    textabstractBackground: Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet. Objective: We studied the gene-diet interaction on BMI at the SIRT1 locus. Design: In 4575 elderly men and women in the population-based Rotterdam S

  8. Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index

    NARCIS (Netherlands)

    M.C. Zillikens (Carola); J.B.J. van Meurs (Joyce); F. Rivadeneira Ramirez (Fernando); A. Hofman (Albert); B.A. Oostra (Ben); E.J.G. Sijbrands (Eric); J.C.M. Witteman (Jacqueline); H.A.P. Pols (Huib); P. Tikka-Kleemola (Päivi); A.G. Uitterlinden (André)

    2010-01-01

    textabstractBackground: Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet. Objective: We studied the gene-diet interaction on BMI at the SIRT1 locus. Design: In 4575 elderly men and women in the population-based Rotterdam

  9. SIRT1 genetic variation is related to BMI and risk of obesity

    NARCIS (Netherlands)

    M.C. Zillikens (Carola); J.B.J. van Meurs (Joyce); F. Rivadeneira Ramirez (Fernando); N. Amin (Najaf); A. Hofman (Albert); B.A. Oostra (Ben); E.J.G. Sijbrands (Eric); J.C.M. Witteman (Jacqueline); H.A.P. Pols (Huib); P. Tikka-Kleemola (Päivi); A.G. Uitterlinden (André)

    2009-01-01

    textabstractOBJECTIVE - SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity. RESEARCH DESIGN AND METHODS - In 6,251 elderly subjects from the prospective, population-based Rotterdam Study, three single nucleotide polymorphisms (SNPs)

  10. Genetics

    DEFF Research Database (Denmark)

    Christensen, Kaare; McGue, Matt

    2016-01-01

    The sequenced genomes of individuals aged ≥80 years, who were highly educated, self-referred volunteers and with no self-reported chronic diseases were compared to young controls. In these data, healthy ageing is a distinct phenotype from exceptional longevity and genetic factors that protect...

  11. Where Birt–Hogg–Dubé meets Cowden Syndrome: mirrored genetic defects in two cases of syndromic oncocytic tumours

    OpenAIRE

    Pradella, Laura Maria; Lang, Martin; Kurelac, Ivana; Mariani, Elisa; Guerra, Flora; Zuntini, Roberta; Tallini, Giovanni; MacKay, Alan; Reis-Filho, Jorge S.; Seri, Marco; Turchetti, Daniela; Gasparre, Giuseppe

    2013-01-01

    Birt–Hogg–Dubè (BHD) is an autosomal dominant syndrome characterised by skin fibrofolliculomas, lung cysts, spontaneous pneumothorax and renal cancer. The association of benign cutaneous lesions and increased cancer risk is also a feature of Cowden Syndrome (CS), an autosomal dominant disease caused by PTEN mutations. BHD and CS patients may develop oncocytomas, rare neoplasias that are phenotypically characterised by a prominent mitochondrial hyperplasia. We here describe the genetic analysi...

  12. Where Birt–Hogg–Dubé meets Cowden Syndrome: mirrored genetic defects in two cases of syndromic oncocytic tumours

    Science.gov (United States)

    Pradella, Laura Maria; Lang, Martin; Kurelac, Ivana; Mariani, Elisa; Guerra, Flora; Zuntini, Roberta; Tallini, Giovanni; MacKay, Alan; Reis-Filho, Jorge S; Seri, Marco; Turchetti, Daniela; Gasparre, Giuseppe

    2013-01-01

    Birt–Hogg–Dubè (BHD) is an autosomal dominant syndrome characterised by skin fibrofolliculomas, lung cysts, spontaneous pneumothorax and renal cancer. The association of benign cutaneous lesions and increased cancer risk is also a feature of Cowden Syndrome (CS), an autosomal dominant disease caused by PTEN mutations. BHD and CS patients may develop oncocytomas, rare neoplasias that are phenotypically characterised by a prominent mitochondrial hyperplasia. We here describe the genetic analysis of a parotid and a thyroid oncocytoma, developed by a BHD and a CS patient, respectively. The BHD lesion was shown to maintain the wild-type allele of FLCN, while losing one PTEN allele. On the other hand, a double heterozygosity for the same two genes was found to be the only detectable tumorigenic hit in the CS oncocytoma. Both conditions occurred in a context of high chromosomal stability, as highlighted by comparative genomic hybridisation analysis. We conclude that, similarly to PTEN, FLCN may not always follow the classical Two Hits model of tumorigenesis and may hence belong to a class of non-canonical tumour suppressor genes. We hence introduce a role of PTEN/FLCN double heterozygosity in syndromic oncocytic tumorigenesis, suggesting this to be an alternative determinant to pathogenic mitochondrial DNA mutations, which are instead the genetic hallmark of sporadic oncocytic tumours. PMID:23386036

  13. Molecular anthropology meets genetic medicine to treat blindness in the North African Jewish population: human gene therapy initiated in Israel.

    Science.gov (United States)

    Banin, Eyal; Bandah-Rozenfeld, Dikla; Obolensky, Alexey; Cideciyan, Artur V; Aleman, Tomas S; Marks-Ohana, Devora; Sela, Malka; Boye, Sanford; Sumaroka, Alexander; Roman, Alejandro J; Schwartz, Sharon B; Hauswirth, William W; Jacobson, Samuel G; Hemo, Itzhak; Sharon, Dror

    2010-12-01

    The history of the North African Jewish community is ancient and complicated with a number of immigration waves and persecutions dramatically affecting its population size. A decade-long process in Israel of clinical-molecular screening of North African Jews with incurable autosomal recessive blindness led to the identification of a homozygous splicing mutation (c.95-2A > T; IVS2-2A > T) in RPE65, the gene encoding the isomerase that catalyzes a key step in the retinoid-visual cycle, in patients from 10 unrelated families. A total of 33 patients (four now deceased) had the severe childhood blindness known as Leber congenital amaurosis (LCA), making it the most common cause of retinal degeneration in this population. Haplotype analysis in seven of the patients revealed a shared homozygous region, indicating a population-specific founder mutation. The age of the RPE65 founder mutation was estimated to have emerged 100-230 (mean, 153) generations ago, suggesting it originated before the establishment of the Jewish community in North Africa. Individuals with this RPE65 mutation were characterized with retinal studies to determine if they were candidates for gene replacement, the recent and only therapy to date for this otherwise incurable blindness. The step from molecular anthropological studies to application of genetic medicine was then taken, and a representative of this patient subgroup was treated with subretinal rAAV2-RPE65 gene therapy. An increase in vision was present in the treated area as early as 15 days after the intervention. This process of genetically analyzing affected isolated populations as a screen for gene-based therapy suggests a new paradigm for disease diagnosis and treatment.

  14. Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: Results of a meta-analysis

    NARCIS (Netherlands)

    J.M. Kerkhof (Hanneke); I. Meulenbelt (Ingrid); A. Gonzalez (Antonio); D.J. Hart (Deborah); A. Hofman (Albert); M. Kloppenburg (Margreet); N.E. Lane; J. Loughlin (John); M.C. Nevitt (Michael); H.A.P. Pols (Huib); F. Rivadeneira Ramirez (Fernando); E. Slagboom (Eline); T.D. Spector (Tim); L. Stolk (Lisette); A. Tsezou (Aspasia); A.G. Uitterlinden (André); A.M. Valdes (Ana Maria); J.B.J. van Meurs (Joyce); A.J. Carr (Andrew Jonathan)

    2010-01-01

    textabstractBackground: The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis.Methods: In the discovery study, the Rotterdam Study-I, 7 single nucleotide polymorphisms (SNPs) were genotyped and tested for association with hip

  15. Age, gender and disability predict future disability in older people: the Rotterdam Study

    Directory of Open Access Journals (Sweden)

    Koes Bart W

    2011-05-01

    Full Text Available Abstract Background To develop a prediction model that predicts disability in community-dwelling older people. Insight in the predictors of disability is needed to target preventive strategies for people at increased risk. Methods Data were obtained from the Rotterdam Study, including subjects of 55 years and over. Subjects who had complete data for sociodemographic factors, life style variables, health conditions, disability status at baseline and complete data for disability at follow-up were included in the analysis. Disability was expressed as a Disability Index (DI measured with the Health Assessment Questionnaire. We used a multivariable polytomous logistic regression to derive a basic prediction model and an extended prediction model. Finally we developed readily applicable score charts for the calculation of outcome probabilities. Results Of the 5027 subjects included, 49% had no disability, 18% had mild disability, 16% had severe disability and 18% had deceased at follow-up after six years. The strongest predictors were age and prior disability. The contribution of other predictors was relatively small. The discriminative ability of the basic model was high; the extended model did not enhance predictive ability. Conclusion As prior disability status predicts future disability status, interventive strategies should be aimed at preventing disability in the first place.

  16. Annual City Festivals as Tools for Sustainable Competitiveness: The World Port Days Rotterdam

    Directory of Open Access Journals (Sweden)

    Erwin van Tuijl

    2016-05-01

    Full Text Available Many cities organize annual local festivals for the positive effects on urban development, although success is far from straightforward. This article reviews a case study of the World Port Days in Rotterdam in order to demonstrate how annual city festivals can contribute to sustainable competitiveness, despite limitations as well. We show how this maritime event—that is jointly organized by the business community, the Port Authority and the City Government—offers benefits for citizens as well as for firms. Our empirical results unveil that the business value of the event includes generation of societal support, image improvement, labor market development and networking, while the value for society refers to education, leisure and to a certain degree to social inclusion. The direct value of the event for business in terms of sales and recruitment is limited, while the long-term effects of educational function deserve further attention. Finally, we provide policy lessons that, when properly contextualized, other cities may help to use annual local festivals as tools for sustainable competitiveness.

  17. Long sleep duration is associated with serum cholesterol in the elderly: the Rotterdam Study.

    Science.gov (United States)

    van den Berg, Julia F; Miedema, Henk M E; Tulen, Joke H M; Neven, Arie Knuistingh; Hofman, Albert; Witteman, Jacqueline C M; Tiemeier, Henning

    2008-11-01

    Epidemiological studies have repeatedly found increased mortality associated with both habitual short and long sleep duration. The mechanisms behind these associations are unclear. We investigated whether objectively measured sleep duration, time in bed, and sleep fragmentation were associated with total cholesterol and high density lipoprotein (HDL) cholesterol in community-dwelling elderly. This cross-sectional study was conducted among 768 participants of the Rotterdam Study, aged 57 to 97 years. Sleep parameters were assessed with actigraphy, a validated method that infers wakefulness and sleep from arm movement. Cholesterol levels in serum were determined in fasting blood samples. All regression analyses were adjusted for age, gender, body mass index, smoking, depressive symptoms, and heart failure. Sleep duration was positively associated with total cholesterol level: beta = 0.11 (95% confidence interval = 0.03-0.18) mmol/l per hour of sleep. Persons who slept longer, and spent more time in bed, also had a higher total/HDL cholesterol ratio. A less fragmented sleep was also associated with higher total cholesterol. Some of these associations showed significant interactions with age. The association between time in bed and total/HDL ratio was mainly driven by persons aged fragmentation and total cholesterol level was most prominent in persons aged >or=70. A longer sleep duration was related to higher total cholesterol level and a higher total/HDL cholesterol ratio. Two separate mechanisms, a longer time in bed and sleep fragmentation, seem to explain these associations in different age categories.

  18. Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study

    Science.gov (United States)

    Moreira, Eduardo M.; Gall, Henning; Leening, Maarten J. G.; Lahousse, Lies; Loth, Daan W.; Krijthe, Bouwe P.; Kiefte-de Jong, Jessica C.; Brusselle, Guy G.; Hofman, Albert; Stricker, Bruno H.; Ghofrani, Hossein A.; Franco, Oscar H.; Felix, Janine F.

    2015-01-01

    Background Pulmonary hypertension is characterized by increased pulmonary artery pressure and carries an increased mortality. Population-based studies into pulmonary hypertension are scarce and little is known about its prevalence in the general population. We aimed to describe the distribution of echocardiographically-assessed pulmonary artery systolic pressure (ePASP) in the general population, to estimate the prevalence of pulmonary hypertension, and to identify associated factors. Methods Participants (n = 3381, mean age 76.4 years, 59% women) from the Rotterdam Study, a population-based cohort, underwent echocardiography. Echocardiographic pulmonary hypertension was defined as ePASP>40 mmHg. Results Mean ePASP was 26.3 mmHg (SD 7.0). Prevalence of echocardiographic pulmonary hypertension was 2.6% (95%CI: 2.0; 3.2). Prevalence was higher in older participants compared to younger ones (8.3% in those over 85 years versus 0.8% in those between 65 and 70), and in those with underlying disorders versus those without (5.9% in subjects with COPD versus 2.3%; 9.2% in those with left ventricular systolic dysfunction versus 2.3%; 23.1% in stages 3 or 4 left ventricular diastolic dysfunction versus 1.9% in normal or stage 1). Factors independently associated with higher ePASP were older age, higher BMI, left ventricular diastolic dysfunction, COPD and systemic hypertension. Conclusion In this large population-based study, we show that pulmonary hypertension as measured by echocardiography has a low prevalence in the overall general population in the Netherlands, but estimates may be higher in specific subgroups, especially in those with underlying diseases. Increased pulmonary arterial pressure is likely to gain importance in the near future due to population aging and the accompanying prevalences of underlying disorders. PMID:26102085

  19. Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study.

    Directory of Open Access Journals (Sweden)

    Eduardo M Moreira

    Full Text Available Pulmonary hypertension is characterized by increased pulmonary artery pressure and carries an increased mortality. Population-based studies into pulmonary hypertension are scarce and little is known about its prevalence in the general population. We aimed to describe the distribution of echocardiographically-assessed pulmonary artery systolic pressure (ePASP in the general population, to estimate the prevalence of pulmonary hypertension, and to identify associated factors.Participants (n = 3381, mean age 76.4 years, 59% women from the Rotterdam Study, a population-based cohort, underwent echocardiography. Echocardiographic pulmonary hypertension was defined as ePASP>40 mmHg.Mean ePASP was 26.3 mmHg (SD 7.0. Prevalence of echocardiographic pulmonary hypertension was 2.6% (95%CI: 2.0; 3.2. Prevalence was higher in older participants compared to younger ones (8.3% in those over 85 years versus 0.8% in those between 65 and 70, and in those with underlying disorders versus those without (5.9% in subjects with COPD versus 2.3%; 9.2% in those with left ventricular systolic dysfunction versus 2.3%; 23.1% in stages 3 or 4 left ventricular diastolic dysfunction versus 1.9% in normal or stage 1. Factors independently associated with higher ePASP were older age, higher BMI, left ventricular diastolic dysfunction, COPD and systemic hypertension.In this large population-based study, we show that pulmonary hypertension as measured by echocardiography has a low prevalence in the overall general population in the Netherlands, but estimates may be higher in specific subgroups, especially in those with underlying diseases. Increased pulmonary arterial pressure is likely to gain importance in the near future due to population aging and the accompanying prevalences of underlying disorders.

  20. Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study.

    Science.gov (United States)

    Brahimaj, Adela; Muka, Taulant; Kavousi, Maryam; Laven, Joop S E; Dehghan, Abbas; Franco, Oscar H

    2017-01-01

    Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study. Type 2 diabetes was defined as a fasting blood glucose ≥7.0 mmol/l or a non-fasting blood glucose ≥11.1 mmol/l. During a median follow-up of 10.9 years, 643 patients with incident type 2 diabetes were identified. After adjusting for age, sex, cohort, fasting status, fasting glucose and insulin, and BMI, both serum DHEA levels (per 1 unit natural log-transformed, HR 0.76, 95% CI 0.67, 0.87) and serum DHEAS levels (per 1 unit natural log-transformed, HR 0.82, 95% CI 0.73, 0.92) were inversely associated with risk of type 2 diabetes in the total population. Further adjustment for alcohol, smoking, physical activity, prevalent cardiovascular disease, serum total cholesterol, use of lipid-lowering medications, systolic BP, treatment for hypertension, C-reactive protein, oestradiol and testosterone did not substantially affect the association between DHEA and incident type 2 diabetes (per 1 unit natural log-transformed, HR 0.80, 95% CI 0.65, 0.99), but abolished the association between DHEAS and type 2 diabetes. Androstenedione was not associated with risk of type 2 diabetes, nor was DHEAS to DHEA ratio. DHEA serum levels might be an independent marker of type 2 diabetes.

  1. Baseline dietary glutamic acid intake and the risk of colorectal cancer: The Rotterdam study.

    Science.gov (United States)

    Viana Veloso, Gilson G; Franco, Oscar H; Ruiter, Rikje; de Keyser, Catherina E; Hofman, Albert; Stricker, Bruno C; Kiefte-de Jong, Jessica C

    2016-03-15

    Animal studies have shown that glutamine supplementation may decrease colon carcinogenesis, but any relation with glutamine or its precursors has not been studied in humans. The primary aim of this study was to assess whether dietary glutamic acid intake was associated with colorectal cancer (CRC) risk in community-dwelling adults. A secondary aim was to evaluate whether the association could be modified by the body mass index (BMI). This study was embedded in the Rotterdam study, which included a prospective cohort from 1990 onward that consisted of 5362 subjects who were 55 years old or older and were free of CRC at the baseline. Glutamic acid was calculated as a percentage of the total protein intake with a validated food frequency questionnaire at the baseline. Incident cases of CRC were pathology-based. During follow-up, 242 subjects developed CRC. Baseline dietary glutamic acid intake was significantly associated with a lower risk of developing CRC (hazard ratio [HR] per percent increase in glutamic acid of protein, 0.78; 95% confidence interval [CI], 0.62-0.99). After stratification for BMI, the risk reduction for CRC by dietary glutamic acid was 42% for participants with a BMI ≤ 25 kg/m(2) (HR per percent increase in glutamic acid of protein, 0.58; 95% CI, 0.40-0.85), whereas no association was found in participants with a BMI > 25 kg/m(2) (HR per percent increase in glutamic acid of protein, 0.97; 95% CI, 0.73-1.31). Our data suggest that baseline dietary glutamic acid intake is associated with a lower risk of developing CRC, but this association may be mainly present in nonoverweight subjects. © 2015 American Cancer Society.

  2. Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study.

    Science.gov (United States)

    Pantavos, Athanasios; Ruiter, Rikje; Feskens, Edith F; de Keyser, Catherine E; Hofman, Albert; Stricker, Bruno H; Franco, Oscar H; Kiefte-de Jong, Jessica C

    2015-05-01

    Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated with breast cancer risk. Data was used from women participating in the Rotterdam Study, a prospective cohort study among subjects aged 55 years and older (N = 3,209). FRAP scores and antioxidant intake (i.e., vitamin A, C, E, selenium, flavonoids and carotenoids) was assessed at baseline by a food frequency questionnaire. Incident cases of breast cancer were confirmed through medical reports. During a median follow-up of 17 years, 199 cases with breast cancer were identified. High dietary FRAP score was associated with a lower risk of breast cancer [hazard ratio (HR): 0.68; 95% confidence intervals (CI): 0.49, 0.96]. No overall association between individual antioxidant intake and breast cancer risk was found. However, low intake of alpha carotene and beta carotene was associated with a higher risk of breast cancer among smokers (HR: 2.48; 95% CI: 1.21, 5.12 and HR: 2.31; 95% CI: 1.12, 4.76 for alpha and beta carotene, respectively) and low intake of flavonoids was associated with breast cancer risk in women over the age of 70 (HR: 1.80; 95% CI: 1.09, 2.99). These results suggest that high overall dietary antioxidant capacity is associated with a lower risk of breast cancer. Individual effects of dietary carotenoids and dietary flavonoids may be restricted to subgroups such as smokers and elderly.

  3. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study.

    Science.gov (United States)

    Cheung, Elim Y L; Bos, Michiel J; Leebeek, Frank W G; Koudstaal, Peter J; Hofman, Albert; de Maat, Moniek P M; Breteler, Monique M B

    2008-08-01

    Haplotypes of the fibrinogen gamma and alpha (FGG and FGA) genes are associated with the structure of the fibrin network and may therefore influence the risk of stroke. We investigated the relationship between common variation in these genes with ischemic and haemorrhagic stroke. The study was based on 6,275 participants of the prospective population-based Rotterdam Study who at baseline (1990-1993) were aged 55 years or over, free from stroke, and had successful assessment of at least one FGG or FGA single nucleotide polymorphisms (SNP). Common haplotypes were estimated using seven tagging SNPs across a 30 kb region containing the FGG and FGA genes. Follow-up for incident stroke was complete until January 1, 2005. Associations between constructed haplotypes and risk of stroke were estimated with an age- and sex-adjusted logistic regression model. We observed 668 strokes, of which 393 were ischemic and 62 haemorrhagic, during a median follow-up time of 10.1 years. FGG + FGA haplotype 3 (H3) was associated with an increased risk of ischemic stroke (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.09-1.69) and the risk estimate for hemorrhagic stroke was 0.71 (95% CI 0.46-1.09) compared to the most frequent H1. The FGG and FGA genes were not associated with stroke or its subtypes when analyzed separately. In conclusion, risk of ischemic stroke was higher in FGG + FGA H3 than in H1. The results suggested that an opposite association may exist for haemorrhagic stroke.

  4. The ENDORSE study: Research into environmental determinants of obesity related behaviors in Rotterdam schoolchildren

    Directory of Open Access Journals (Sweden)

    Looij-Jansen Petra

    2008-04-01

    Full Text Available Abstract Background Children and adolescents are important target groups for prevention of overweight and obesity as overweight is often developed early in life and tracks into adulthood. Research into behaviors related to overweight (energy balance-related behaviors and the personal and environmental determinants of these behaviors is fundamental to inform prevention interventions. In the Netherlands and in other countries systematic research into environmental determinants of energy balance related behaviors in younger adolescents is largely lacking. This protocol paper describes the design, the components and the methods of the ENDORSE study (Environmental Determinants of Obesity in Rotterdam SchoolchildrEn, that aims to identify important individual and environmental determinants of behaviors related to overweight and obesity and the interactions between these determinants among adolescents. Methods The ENDORSE study is a longitudinal study with a two-year follow-up of a cohort of adolescents aged 12–15 years. Data will be collected at baseline (2005/2006 and at two years follow-up (2007/2008. Outcome measures are body mass index (BMI, waist circumference, time spent in physical activity and sedentary behaviors, and soft drink, snack and breakfast consumption. The ENDORSE study consists of two phases, first employing qualitative research methods to inform the development of a theoretical framework to examine important energy balance related behaviors and their determinants, and to inform questionnaire development. Subsequently, the hypothetical relationships between behavioral determinants, energy balance related behaviors and BMI will be tested in a quantitative study combining school-based surveys and measurements of anthropometrical characteristics at baseline and two-year follow-up. Discussion The ENDORSE project is a comprehensive longitudinal study that enables investigation of specific environmental and individual determinants of

  5. The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Mullerian hormone

    DEFF Research Database (Denmark)

    Lauritsen, Mette Petri; Bentzen, J G; Pinborg, Anja Bisgaard;

    2014-01-01

    STUDY QUESTION: What is the prevalence in a normal population of polycystic ovary syndrome (PCOS) according to the Rotterdam criteria versus revised criteria including anti-Müllerian hormone (AMH)? SUMMARY ANSWER: The prevalence of PCOS was 16.6% according to the Rotterdam criteria. When replacing...... the criterion for polycystic ovaries by antral follicle count (AFC) > 19 or AMH > 35 pmol/l, the prevalence of PCOS was 6.3 and 8.5%, respectively. WHAT IS KNOWN ALREADY?: The Rotterdam criteria state that two out of the following three criteria should be present in the diagnosis of PCOS: oligo......-anovulation, clinical and/or biochemical hyperandrogenism and polycystic ovaries (AFC ≥ 12 and/or ovarian volume >10 ml). However, with the advances in sonography, the relevance of the AFC threshold in the definition of polycystic ovaries has been challenged, and AMH has been proposed as a marker of polycystic ovaries...

  6. [Effects of pregnancy and changes in body weight on polycystic ovary syndrome phenotypes according to the Rotterdam criteria].

    Science.gov (United States)

    Echiburú, Bárbara; Ladrón de Guevara, Amanda; Pereira, Cecilia; Pérez, Constanza; Michael, Pía; Crisosto, Nicolás; Sir-Petermann, Teresa

    2014-08-01

    Polycystic Ovary Syndrome (PCOS) is tightly associated with insulin resistance and obesity and characterized by hyperandrogenism, chronic oligo-anovulation and polycystic ovarian morphology when fully expressed. The 2003 Rotterdam consensus proposed that two or three of these features were necessary to make the diagnosis, which generated four phenotypes. Several studies have suggested that these phenotypes could differ in their metabolic and endocrine characteristics and that they could vary in the same patient when analyzed throughout life. To determine if the initial classification of PCOS phenotypes is modified by different physiological conditions. We performed a non-concurrent prospective analysis of 88 women with PCOS according to the Rotterdam criteria. The effect of physiological conditions such as changes in body weight, pregnancy and ageing more than five years on PCOS phenotype expression was analyzed. Twenty four percent of women became pregnant, 37% decreased and 24% increased their body weight during follow up. These conditions modified significantly the proportion of the different phenotypes (c2 = 32.2, p change to a better phenotype (p = 0.047) and even a normalization of the PCOS condition in 27% of the patients. On the other hand, an increase in body weight modifying body mass index in one unit, conferred an 8% probability of changing to a worst phenotype. Pregnancy and changes in body weight significantly modify PCOS phenotypes.

  7. Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS.

    Science.gov (United States)

    Campos-Obando, Natalia; Koek, W Nadia H; Hooker, Elizabeth R; van der Eerden, Bram Cj; Pols, Huibert A; Hofman, Albert; van Leeuwen, Johannes Ptm; Uitterlinden, Andre G; Nielson, Carrie M; Zillikens, M Carola

    2017-02-08

    Extreme phosphate levels (P) have been associated with mineralization defects and increased fracture risk. Whether P within normal range is related to bone health in the general population is not well understood. To investigate the association of P with bone mineral density (BMD) and fracture risk, we assessed two population-based cohorts: the Dutch Rotterdam Study (RS-I, RS-II, RS-III; n = 6791) and the US Osteoporotic Fractures in Men (MrOS; n = 5425) study. The relationship of P with lumbar spine (LS) and femoral neck (FN) BMD was tested in all cohorts via linear models; fracture risk was tested in RS-I, RS-II, and MrOS through Cox models, after follow-up of 8.6, 6.6, and 10.9 years, respectively. Adjustments were made for age, body mass index, smoking, serum levels of calcium, potassium, 25-hydroxyvitamin D, estimated glomerular filtration rate (eGFR), FN-BMD, prevalent diabetes, and cardiovascular disease. Additional adjustments were made for phosphate intake, parathyroid hormone, and fibroblast growth factor 23 levels in MrOS. We further stratified by eGFR. Results were pooled through study-level meta-analyses. Hazard ratios (HR) and betas (β) (from meta-analyses) are expressed per 1 mg/dL P increase. P was positively associated with fracture risk in men and women from RS, and findings were replicated in MrOS (pooled HR all [95% CI]: 1.47 [1.31-1.65]). P was associated with fracture risk in subjects without chronic kidney disease (CKD): all (1.44 [1.26-1.63]) and in men with CKD (1.93 [1.42-2.62]). P was inversely related to LS-BMD in men (β: -0.06 [-0.11 to -0.02]) and not to FN-BMD in either sex. In summary, serum P was positively related to fracture risk independently from BMD and phosphate intake after adjustments for potential confounders. P and LS-BMD were negatively related in men. Our findings suggest that increased P levels even within normal range might be deleterious for bone health in the normal population. © 2017 American Society for

  8. Dietary vitamin A intake and bone health in the elderly: the Rotterdam Study.

    Science.gov (United States)

    de Jonge, E A L; Kiefte-de Jong, J C; Campos-Obando, N; Booij, L; Franco, O H; Hofman, A; Uitterlinden, A G; Rivadeneira, F; Zillikens, M C

    2015-12-01

    High vitamin A intake may be associated with a decreased bone mineral density (BMD) and increased risk of fractures. Our objectives were to study whether dietary intake of vitamin A (total, retinol or beta-carotene) is associated with BMD and fracture risk and if associations are modified by body mass index (BMI) and vitamin D. Participants were aged 55 years and older (n=5288) from the Rotterdam Study, a population-based prospective cohort. Baseline vitamin A and D intake was measured by a food frequency questionnaire. BMD was measured by dual-energy X-ray absorptiometry at four visits between baseline (1989-1993) and 2004. Serum vitamin D was assessed in a subgroup (n=3161). Fracture incidence data were derived from medical records with a mean follow-up time of 13.9 years. Median intake of vitamin A ranged from 684 retinol equivalents (REs)/day (quintile 1) to 2000 REs/day (quintile 5). After adjustment for confounders related to lifestyle and socioeconomic status, BMD was significantly higher in subjects in the highest quintile of total vitamin A (mean difference in BMD (95% confidence interval (CI))=11.53 (0.37-22.7) mg/cm(2)) and retinol intake (mean difference in BMD (95% CI)=12.57 (1.10-24.05) mg/cm(2)) than in the middle quintile. Additional adjustment for BMI diluted these associations. Fracture risk was reduced in these subjects. Significant interaction was present between intake of retinol and overweight (BMI >25 kg/m(2)) in relation to fractures (P for interaction =0.05), but not BMD. Stratified analysis showed that these favourable associations with fracture risk were only present in overweight subjects (BMI >25 kg/m(2)). No effect modification by vitamin D intake or serum levels was observed. Our results suggest a plausible favourable relation between high vitamin A intake from the diet and fracture risk in overweight subjects, whereas the association between vitamin A and BMD is mainly explained by BMI.

  9. Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study.

    Science.gov (United States)

    Brahimaj, Adela; Ligthart, Symen; Ghanbari, Mohsen; Ikram, Mohammad Arfan; Hofman, Albert; Franco, Oscar H; Kavousi, Maryam; Dehghan, Abbas

    2017-03-01

    The immune response involved in each phase of type 2 diabetes (T2D) development might be different. We aimed to identify novel inflammatory markers that predict progression from normoglycemia to pre-diabetes, incident T2D and insulin therapy. We used plasma levels of 26 inflammatory markers in 971 subjects from the Rotterdam Study. Among them 17 are novel and 9 previously studied. Cox regression models were built to perform survival analysis. During a follow-up of up to 14.7 years (between April 1, 1997, and Jan 1, 2012) 139 cases of pre-diabetes, 110 cases of T2D and 26 cases of insulin initiation were identified. In age and sex adjusted Cox models, IL13 (HR = 0.78), EN-RAGE (1.30), CFH (1.24), IL18 (1.22) and CRP (1.32) were associated with incident pre-diabetes. IL13 (0.62), IL17 (0.75), EN-RAGE (1.25), complement 3 (1.44), IL18 (1.35), TNFRII (1.27), IL1ra (1.24) and CRP (1.64) were associated with incident T2D. In multivariate models, IL13 (0.77), EN-RAGE (1.23) and CRP (1.26) remained associated with pre-diabetes. IL13 (0.67), IL17 (0.76) and CRP (1.32) remained associated with T2D. IL13 (0.55) was the only marker associated with initiation of insulin therapy in diabetics. Various inflammatory markers are associated with progression from normoglycemia to pre-diabetes (IL13, EN-RAGE, CRP), T2D (IL13, IL17, CRP) or insulin therapy start (IL13). Among them, EN-RAGE is a novel inflammatory marker for pre-diabetes, IL17 for incident T2D and IL13 for pre-diabetes, incident T2D and insulin therapy start.

  10. Air quality and health impact of PM10 and EC in the city of Rotterdam, the Netherlands in 1985-2008

    NARCIS (Netherlands)

    Keuken, M.; Zandveld, P.Y.J.; Elshout, S. van den; Janssen, N.A.H.; Hoek, G.

    2011-01-01

    A health impact assessment (HIA) of PM10 and elemental carbon (EC) was performed for the period 1985-2008 in the city of Rotterdam. The spatial distribution of the concentrations was modeled by the URBIS model. The modeling results for 2008 were validated by PM10 and EC measurements at various locat

  11. Impact on air quality of measures to reduce CO2 emissions from road traffic in Basel, Rotterdam, Xi'an and Suzhou

    NARCIS (Netherlands)

    Keuken, M.P.; Jonkers, S.; Verhagen, H.L.M.; Perez, L.; Truëb, S.; Okkerse, W.J.; Liu, J.; Pan, X.C.; Zheng, L.; Wang, H.; Xu, R.; Sabel, C.E.

    2014-01-01

    Two traffic scenarios to reduce CO2 emissions from road traffic in two European cities (Basel and Rotterdam) and two Chinese cities (Xi'an and Suzhou) were evaluated in terms of their impact on air quality. The two scenarios, one modelling a reduction of private vehicle kilometres driven by 10% on u

  12. High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: The Rotterdam study

    NARCIS (Netherlands)

    L. Oei (Ling); M.C. Zillikens (Carola); A. Dehghan (Abbas); G.H.S. Buitendijk (Gabrielle); M.C. Castaño Betancourt (Martha); K. Estrada Gil (Karol); L. Stolk (Lisette); E.H.G. Oei (Edwin); J.B.J. van Meurs (Joyce); J.A.M.J.L. Janssen (Joseph); A. Hofman (Albert); J.P.T.M. van Leeuwen (Hans); J.C.M. Witteman (Jacqueline); H.A.P. Pols (Huib); A.G. Uitterlinden (André); C.C.W. Klaver (Caroline); O.H. Franco (Oscar); F. Rivadeneira Ramirez (Fernando)

    2013-01-01

    textabstractOBJECTIVE - Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications. RESEARCH DESIGN AND METHODS - Data of 4,135 participants of the Rotterdam Study, a prosp

  13. Impact on air quality of measures to reduce CO2 emissions from road traffic in Basel, Rotterdam, Xi'an and Suzhou

    NARCIS (Netherlands)

    Keuken, M.P.; Jonkers, S.; Verhagen, H.L.M.; Perez, L.; Truëb, S.; Okkerse, W.J.; Liu, J.; Pan, X.C.; Zheng, L.; Wang, H.; Xu, R.; Sabel, C.E.

    2014-01-01

    Two traffic scenarios to reduce CO2 emissions from road traffic in two European cities (Basel and Rotterdam) and two Chinese cities (Xi'an and Suzhou) were evaluated in terms of their impact on air quality. The two scenarios, one modelling a reduction of private vehicle kilometres driven by 10% on

  14. Analysis of an infill scenario for Rotterdam. Traffic noise, air pollution, and public health in relation to urban density and traffic of cars and bicycles

    NARCIS (Netherlands)

    Schaminée, S.; Rietveld, E.; Salomons, E.; Kluizenaar, Y. de; Borsboom, J.; Borst, H.; Guit, M.

    2012-01-01

    An analysis is presented of various elements of an infill scenario for the center of Rotterdam in the year 2030, corresponding to a population increase from about 30,000 to 60,000 inhabitants. We have implemented detailed future building designs in our software instrument Urban Strategy, and

  15. THE DUTCH PCB DIOXIN STUDY - CONTENTS OF DIOXINS, PLANAR AND OTHER PCBS IN HUMAN-MILK FROM THE ROTTERDAM AND GRONINGEN AREA

    NARCIS (Netherlands)

    TUINSTRA, LGMT; HUISMAN, M; BOERSMA, ER

    1994-01-01

    In two areas (Groningen and Rotterdam): individual human milk samples (24 hr.) were obtained 10 and 42 days after delivery from about 200 mothers. In all samples non-planar PCBs, including some mono-orthochlorine substituted PCBs were determined. All first samples, and a smaller number of the second

  16. Safety and immunogenicity of the RIVM hexavalent meningococcal B vesicle vaccine for Rotterdam children aged 2-3 and 7-8

    NARCIS (Netherlands)

    Labadie J; de Kleijn ED; Lafeber AB; Mees MMM; Booy K; de Groot R; van Omme GW; van Dijken H; Kuipers AJ; van den Dobbelsteen G; Juttmann RE; Wala M; van Alphen AJW; Rumke HC; LVO

    2000-01-01

    In dit rapport wordt verslag gedaan van een gerandomiseerde gecontroleerd fase-II klinische studie naar de veiligheid en immunogeniciteit van het RIVM hexavalente MenB vesicle vaccin in 189 kinderen van 2-3 jaar en 168 kinderen van 7-8 jaar in de stad Rotterdam. Twee concentraties van het MenB

  17. The Role of Education in Teaching Norms and Values to Adult Newcomers: An Analysis of Integration Policy in the Netherlands, with Emphasis on the City of Rotterdam

    Science.gov (United States)

    Koehler, Maryan

    2009-01-01

    This paper presents research on the current debate in the Netherlands regarding integration and the teaching of 'norms and values' to adult newcomers. Data consisting of national and local (city of Rotterdam) integration policy documents and interviews with those influential in policy making were analyzed using a grounded theory approach. The…

  18. The development of alcohol consumption and problem drinking in Rotterdam 1980-1994: more problem drinking amongst the young and the middle aged

    NARCIS (Netherlands)

    H.F.L. Garretsen (Henk); I.M.B. Bongers (Inge); J.A. van Oers (Johannes Anna Maria); L.A. van de Goor

    1999-01-01

    textabstractIn 1980/1981 and in 1994, two surveys on problem drinking were conducted in the city of Rotterdam. This article presents data on changes in alcohol consumption and alcohol-related problems between 1981 and 1994. Special attention has been paid to possible sh

  19. Study and Relization of College Sports Meeting Schedule Based on Immune Genetic Algorithm%基于免疫遗传算法的高校运动会赛程编排问题研究与实现

    Institute of Scientific and Technical Information of China (English)

    蒋尚亭

    2014-01-01

    随着信息化技术在高校的推广,我国部分高校已经开始利用计算机技术来进行高校运动会的管理,但赛程编排工作一直困扰着运动会管理人员,经过分析和研究提出一种基于免疫遗传算法的高校运动会赛程编排方法。免疫遗传算法将生物免疫原理引入到传统遗传算法中,通过接种疫苗来提高抗体的适应度,从而防止种群快速退化。最后通过相关实验说明免疫遗传算法与传统遗传算的性能差异,并利用免疫遗传算法来解决高校运动会赛程编排问题。%With the popularization of information technology in colleges and universities, some universities in China begin to use computer technology in college sports meeting management, but the arrangement work has been plagued by sports management personnel, through the analysis and study, it presents a method of arranging the movement will be based on immune genetic algorithm. Immune genetic algorithm to the biological immune principle is introduced to the traditional genetic algorithm, through vaccination to improve antibody fitness, so as to prevent the rapid degradation of population. Finally this paper illustrate the performance differences of immune genetic algorithm and traditional genetic algorithm through experiments, and the use of immune genetic algorithm to solve the sports meeting schedule problem.

  20. Genetic architecture of circulating lipid levels

    DEFF Research Database (Denmark)

    Demirkan, Ayşe; Amin, Najaf; Isaacs, Aaron

    2011-01-01

    the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independent population-based study, the Rotterdam Study-II (RS-II). We additionally tested for evidence of a shared genetic basis for different lipid phenotypes. Finally, the polygenic score approach was used to identify...... levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from...... suggested a small overlap between the polygenic backgrounds involved in determining LDL-C, HDL-C and TG levels. Pathway analysis utilizing the best polygenic score for TC uncovered extra information compared with using only genome-wide significant loci. These results suggest that the genetic architecture...

  1. Managing Meetings

    Science.gov (United States)

    Hay, Susan

    2010-01-01

    Meetings are a means of giving people a chance to contribute. Meetings are also the nursery where the people's skills of listening, speaking, and building good working relationships are honed. They are where people practice being courteously challenging and confident, and they are where people are fascinated and fascinating. Meetings are where…

  2. Mining drug-disease relationships as a complement to medical genetics-based drug repositioning: Where a recommendation system meets genome-wide association studies.

    Science.gov (United States)

    Wang, H; Gu, Q; Wei, J; Cao, Z; Liu, Q

    2015-05-01

    A novel recommendation-based drug repositioning strategy is presented to simultaneously determine novel drug indications and side effects in one integrated framework. This strategy provides a complementary method to medical genetics-based drug repositioning, which reduces the occurrence of false positives in medical genetics-based drug repositioning, resulting in a ranked list of new candidate indications and/or side effects with different confidence levels. Several new drug indications and side effects are reported with high prediction confidences.

  3. The near demise and subsequent revival of classical genetics for investigating Caenorhabditis elegans embryogenesis: RNAi meets next-generation DNA sequencing

    OpenAIRE

    Bowerman, Bruce

    2011-01-01

    Molecular genetic investigation of the early Caenorhabditis elegans embryo has contributed substantially to the discovery and general understanding of the genes, pathways, and mechanisms that regulate and execute developmental and cell biological processes. Initially, worm geneticists relied exclusively on a classical genetics approach, isolating mutants with interesting phenotypes after mutagenesis and then determining the identity of the affected genes. Subsequently, the discovery of RNA in...

  4. Anthropometric, clinical, and metabolic comparisons of the four Rotterdam PCOS phenotypes: A prospective study of PCOS women

    Directory of Open Access Journals (Sweden)

    Sujata Kar

    2013-01-01

    Full Text Available Aims: 1. To study the distribution of various Rotterdam classified phenotypes of polycystic ovarian syndrome (PCOS women, in our population. 2. To compare the four phenotypes with respect to anthropometric, clinical, and metabolic parameters. 3. To report the prevalence of insulin resistance (IR and metabolic syndrome in these women. Settings and Design: Private practice, Prospective cross-sectional comparative study. Materials and Methods: Women attending gynecology outpatient with the primary complains of irregular menses and/or infertility were evaluated. Each of them underwent detailed clinical examination, transvaginal sonography, and biochemical and hormonal assays. Four hundred and ten women with a clinical diagnosis of PCOS based on Rotterdam criteria were included in the study. The four phenotypes were 1 PCO complete, that is oligo/anovulation (O + polycystic ovaries (P + hyperandrogenism (H 2 P + O, 3 P + H, and 4 O + H. All women were also evaluated for metabolic syndrome (American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI, modified Adult Treatment Panel (ATP III 2005 guidelines and IR (homeostatic model assessment-IR (HOMA-IR. Statistical Analysis: Statistical Package for Social Sciences (SPSS version 18. Results: Largest group was PCOS complete (65.6% followed by P + O (22.2%; H + O (11.2%; and P + H (0.9%. Overall prevalence of metabolic syndrome was 35.07%. Hyperandrogenic phenotyptes; H + O (50% and P + H + O (37.04%, had significantly higher prevalence of metabolic syndrome than normoandrogenic P + O phenotype (10% (P ≤ 0.001. Body mass index (BMI ≥ 25 (P = 0.0004; odds ratio (OR = 3.07 (1.6574-5.7108, 95% CI, waist circumference (WC ≥ 80 cm (P = 0.001; OR = 3.68 (1.6807-8.0737, 95% CI and family history of diabetes (P = 0.019; OR 1.82 (1.1008-3.0194, 95% CI, were strongly associated with the presence of metabolic syndrome. The overall prevalence of IR in PCOS women was 30.44% (HOMA-IR cutoff

  5. Logic Meeting

    CERN Document Server

    Tugué, Tosiyuki; Slaman, Theodore

    1989-01-01

    These proceedings include the papers presented at the logic meeting held at the Research Institute for Mathematical Sciences, Kyoto University, in the summer of 1987. The meeting mainly covered the current research in various areas of mathematical logic and its applications in Japan. Several lectures were also presented by logicians from other countries, who visited Japan in the summer of 1987.

  6. Ischemic Postconditioning After Routine Thrombus Aspiration During Primary Percutaneous Coronary Intervention: Rationale and Design of the POstconditioning Rotterdam Trial.

    Science.gov (United States)

    Yetgin, Tuncay; van Kranenburg, Matthijs; Ten Cate, Tim; Duncker, Dirk J; de Boer, Menko-Jan; Diletti, Roberto; van Geuns, Robert-Jan M; Zijlstra, Felix; Manintveld, Olivier C

    2016-10-01

    Whether ischemic postconditioning (IPOC) immediately after routine thrombus aspiration (TA) reduces infarct size (IS) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) has not been established. The POstconditioning Rotterdam Trial (PORT) is a dual-center, prospective, open-label, randomized trial with blinded endpoint evaluation enrolling 72 subjects with first-time STEMI, and an occluded infarct-related artery (IRA) without collaterals undergoing PPCI. Subjects are randomized 1:1 to a strategy of IPOC immediately after TA followed by stenting of the IRA or to conventional percutaneous coronary intervention (PCI), including TA followed by stenting of the IRA (controls). Cardiac magnetic resonance imaging (MRI) is performed at 3-5 days after STEMI and at 3 months. The primary endpoint is IS at 3 months measured by delayed enhancement MRI. Other secondary endpoints include MRI-derived microvascular obstruction (MVO), left ventricular ejection fraction, myocardial salvage index, enzymatic IS, ST-segment resolution, myocardial blush grade, microcirculatory resistance, inflammation markers, and clinical events through 3-month follow-up. PORT is testing the hypothesis that adding IPOC (against lethal reperfusion injury) to TA (against distal embolization and MVO) is cardioprotective and reduces ultimate IS in STEMI patients undergoing PPCI (Dutch Trial Register identifier: NTR4040). © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  7. Historical ecology meets conservation and evolutionary genetics: a secondary contact zone between Carabus violaceus (Coleoptera, Carabidae populations inhabiting ancient and recent woodlands in north-western Germany

    Directory of Open Access Journals (Sweden)

    Andrea Matern

    2011-05-01

    Full Text Available Only very few cases have documented that an increase in connectivity after a period of fragmentation in ecological time has had an effect on the distribution, genetic structure and morphology of stenotopic species. In this study we present an example of clinal variability in a woodland ground beetle as a result of changes in the connectivity of a landscape during the last two centuries. The study area hosts both the nominate form C. violaceus s. str. and the subspecies C. v. purpurascens, which is ranked as a distinct species by some authors. We studied 12 Carabus violaceus populations from a 30 km transect of ancient and recent forests in north-western Germany. We analyzed three polymorphic enzyme loci, classified the elytron sculpture and measured the shape of the aedeagus tip of the specimens. C. violaceus showed secondary gradients both in allozyme markers and morphometric characters in our study area. A genetic differentiation of 16% between the populations is high but lies within the range of intraspecific variability in habitat specialists of the genus Carabus. Populations had no significant deficit of heterozygotes. We found many hybrid populations in terms of morphological properties. This study highlights the conservation value of ancient woodland and the consequences of landscape connectivity and defragmentation on the genetic setting of a ground beetle. Moreover, it shows that differences in the external shape of male genitalia do not prevent gene flow within the genus Carabus. Thus, the establishment of species status should not exclusively be based on this property.

  8. Public meetings

    CERN Multimedia

    Staff Association

    2014-01-01

    You were hundreds of persons to participate in our information meetings of October 3 and 6 2014, and we thank you for your participation! The full presentation is available here. A summary of the topics is available here (in french).

  9. Public meetings

    CERN Multimedia

    Staff Association

    2017-01-01

    Do you have questions about the elections to the Staff Council, 2017 MERIT exercise, EVE and School, LD to IC exercise, CHIS, the Pension Fund… Come get informed and ask your questions at our public meetings. These public meetings are also an opportunity to get the more information on current issues. Benefit from this occasion to get the latest news and to discuss with the representatives of the statutory body that is the Staff Association!

  10. Mapping the unseen: geoarchaeological prospection to the Stone Age heritage in the early Holocene delta deposits of the Rotterdam harbor area (the Netherlands)

    Science.gov (United States)

    Vos, Peter

    2013-04-01

    Mapping the unseen: geoarchaeological prospection to the Stone Age heritage in the early Holocene delta deposits of the Rotterdam harbor area (the Netherlands) Peter C. Vos1 & Dimitri Schiltmans2 1) Deltares, PO Box 85467, 3508 AL Utrecht, The Netherlands E-mail: peter.vos@deltares.nl 2) Bureau Oudheidkundig Onderzoek Rotterdam, Ceintuurbaan 213b, 3051 KC Rotterdam, The Netherlands E-mail: dea.schiltmans@Rotterdam.nl The Port of Rotterdam (PoR) is expanding the Rotterdam harbor area into the sea. A new channel, the Yangtze harbor, will be dug out to a depth of 20 m below sea level in order to connect the existing Maasvlakte harbor area with the new harbor area under construction. The upper part of the sediment, which was dredged out in order to create the new channel, consisted mainly of marine offshore sands. In the lower part, at a depth of about 17-22 m below the Dutch Ordnance Datum (NAP), Late Weichselian fluvial and aeolian sands and Early Holocene deltaic deposits of the Rhine - Meuse were present. From earlier dredging activities in the Maasvlakte area it was known that the Late Weichselian / Early Holocene deposits contain Late Paleolithic and Early Mesolithic artefacts. The deepening of the Yangtze harbor would affect the Late-Weichselian / Early Holocene deposits and destroy the archaeologically valuable objects in these layers. The aim of the archaeological Yangtze harbor project was to predict those locations where archaeological heritage from the Stone Age could be found. A geological-geogenetic approach was applied in order to determine the optimal palaeo-environmental locations for man to settle. A 3D palaeolandscape model was constructed of the harbor area; an area which was about 0.5 km wide and 3 km long. Given this palaeolandscape model, the potential archaeological sites were selected. The multidisciplinary prospection research was carried out in several steps. After each research step the strategy of the following research phase was determined

  11. The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study.

    Directory of Open Access Journals (Sweden)

    Taulant Muka

    Full Text Available The association between metabolic syndrome (MS and bone health remains unclear. We aimed to study the association between MS and hip bone geometry (HBG, femoral neck bone mineral density (FN-BMD, and the risk of osteoporosis and incident fractures. Data of 2040 women and 1510 men participants in the third visit (1997-1999 of the Rotterdam Study (RSI-3, a prospective population based cohort, were available (mean follow-up 6.7 years. MS was defined according to the recent harmonized definition. HBG parameters were measured at the third round visit whereas FN-BMD was assessed at the third round and 5 years later. Incident fractures were identified from medical registry data. After correcting for age, body mass index (BMI, lifestyle factors and medication use, individuals with MS had lower bone width (β = -0.054, P = 0.003, lower cortical buckling ratio (β = -0.81, P = 0.003 and lower odds of having osteoporosis (odds ratio =0.56, P = 0.007 in women but not in men. Similarly, MS was associated with higher FN-BMD only in women (β = 0.028, P=0.001. In the analyses of MS components, the glucose component (unrelated to diabetes status was positively associated with FN-BMD in both genders (β = 0.016, P = 0.01 for women and β = 0.022, P = 0.004 for men. In men, waist circumference was inversely associated with FN-BMD (β = -0.03, P = 0.004. No association was observed with fracture risk in either sex. In conclusion, women with MS had higher FN-BMD independent of BMI. The glucose component of MS was associated with high FN-BMD in both genders, highlighting the need to preserve glycemic control to prevent skeletal complications.

  12. The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study

    Science.gov (United States)

    Muka, Taulant; Trajanoska, Katerina; Kiefte-de Jong, Jessica C.; Oei, Ling; Uitterlinden, André G; Hofman, Albert; Dehghan, Abbas; Zillikens, M. Carola; Franco, Oscar H.; Rivadeneira, Fernando

    2015-01-01

    The association between metabolic syndrome (MS) and bone health remains unclear. We aimed to study the association between MS and hip bone geometry (HBG), femoral neck bone mineral density (FN-BMD), and the risk of osteoporosis and incident fractures. Data of 2040 women and 1510 men participants in the third visit (1997–1999) of the Rotterdam Study (RSI-3), a prospective population based cohort, were available (mean follow-up 6.7 years). MS was defined according to the recent harmonized definition. HBG parameters were measured at the third round visit whereas FN-BMD was assessed at the third round and 5 years later. Incident fractures were identified from medical registry data. After correcting for age, body mass index (BMI), lifestyle factors and medication use, individuals with MS had lower bone width (β = -0.054, P = 0.003), lower cortical buckling ratio (β = -0.81, P = 0.003) and lower odds of having osteoporosis (odds ratio =0.56, P = 0.007) in women but not in men. Similarly, MS was associated with higher FN-BMD only in women (β = 0.028, P=0.001). In the analyses of MS components, the glucose component (unrelated to diabetes status) was positively associated with FN-BMD in both genders (β = 0.016, P = 0.01 for women and β = 0.022, P = 0.004 for men). In men, waist circumference was inversely associated with FN-BMD (β = -0.03, P = 0.004). No association was observed with fracture risk in either sex. In conclusion, women with MS had higher FN-BMD independent of BMI. The glucose component of MS was associated with high FN-BMD in both genders, highlighting the need to preserve glycemic control to prevent skeletal complications. PMID:26066649

  13. A comparative study between Marshall and Rotterdam CT scores in predicting early deaths in patients with traumatic brain injury in a major tertiary care hospital in Nepal

    Institute of Scientific and Technical Information of China (English)

    Sunil Munakomi

    2016-01-01

    Purpose:CT plays a crucial role in the early assessment of patients with traumatic brain injury (TBI).Marshall and Rotterdam are the mostly used scoring systems,in which CT findings are grouped differently.We sought to determine the values of the scoring system and initial CT findings in predicting the death at hospital discharge (early death) in patients with TBI.Methods:There were consecutive 634 traumatic neurosurgical patients with mild-to-severe TBI admitted to the emergency department of College of Medical Sciences.Their initial CT and status at hospital discharge (dead or alive) were reviewed,and both CT scores were calculated.We examined whether each score is related to early death;compared the two scoring systems' performance in predicting early death,and identified the CT findings that are independent predictors for early death.Results:Both imaging score (Marshall) and clinical score (Rotterdam) can be used to reliably predict mortality in patients with acute traumatic brain injury with high prognostic accuracy.Other specific CT characteristics that can be used to predict early mortality are traumatic subarachnoid hemorrhage,midline shift and status of the peri-mesencephalic cisterns.Conclusions:Marshall CT classification has strong predictive power,but greater discrimination can be obtained if the individual CT parameters underlying the CT classification are included in a prognostic model as in Rotterdam score.Consequently,for prognostic purposes,we recommend the use of individual characteristics rather than the CT classification.Performance of CT models for predicting outcome in TBI can be significantly improved by including more details of variables and by adding other variables to the models.

  14. [Health risk railroad noise - prognosis of potential health risks subsequent to night-time exposure to railroad noise in the German part of the Transversal Rotterdam Genova].

    Science.gov (United States)

    Greiser, E

    2014-12-01

    Based on risk coefficients for cardiovascular and psychiatric disease derived from a case-control study in the vicinity of a major German airport, statistics on persons exposed to night-time railroad noise in the vicinity of the Rotterdam-Genova Transversal, and on health expenditure calculations by the Federal Statistical Office of Germany a prognosis on effects of railroad noise was performed. It resulted for 1 10-year period in nearly 75 000 excess cases of diseases, nearly 30 000 excess deaths and health expenditures of 3.8 billion euros.

  15. Public meeting

    CERN Multimedia

    HR Department

    2010-01-01

    Dear Colleagues, I am pleased to invite you to a public meeting which will be held on Thursday 11 November 2010 at 2:30 p.m., in the Main Auditorium (welcome coffee from 2 p.m.) In this meeting Sigurd Lettow, Director for Administration and General Infrastructure will present the Management’s proposals towards restoring full funding of the Pension Fund. The meeting will follow discussions which took place with the Staff Association, at the Standing Concertation Committee (CCP) of 1 November 2010 and will be held with the Members States, at the Tripartite Employment Conditions Forum (TREF) of 4 November 2010. You will be able to attend this presentation in the Main Auditorium or via the webcast. The Management will also be available to reply to your questions on this subject. Best regards, Anne-Sylvie Catherin

  16. ACCU Meeting

    CERN Multimedia

    PH Department

    2010-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 June 2010 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department CERN Global Network An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairperson in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) ...

  17. ACCU Meeting

    CERN Multimedia

    PH Department

    2010-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 December 2010 at 9:15 a.m. in room 60-6-002 Chairperson's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department The CERN Ombuds The new account management system Crèche progress + Restaurants Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch   Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): ...

  18. ACCU MEETING

    CERN Multimedia

    PH Department

    2010-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 September 2010 at 9:15 a.m. in Room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS Department An update on Safety at CERN The CERN Summer Student program Bringing Library services to users Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairperson in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): ...

  19. ACCU Meeting

    CERN Multimedia

    PH Department

    2011-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 March 2011 At 9:15 a.m. in room 60-6-002   Chairperson's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department Update on Safety at CERN The new account management system Users’ Office news Any Other Business Agenda for the next meeting   Anyone wishing to raise any points under item 10 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium ...

  20. STAFF MEETING

    CERN Multimedia

    2003-01-01

    I would like to invite all members of the CERN Personnel to a meeting on Tuesday 13 January 2004 at 4:00 p.m. - Main Auditorium (bldg. 500) to convey my best wishes for the new year and to present a perspective of CERN's future activities. Closed-circuit transmission of the meeting will be available in the Council Chamber and in the AB Auditorium (Meyrin), the AB Auditorium (Prévessin), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). A simultaneous translation into English will be available in the main Auditorium. Robert AYMAR

  1. STAFF MEETING

    CERN Multimedia

    2004-01-01

    I would like to invite all members of the CERN Personnel to a meeting on Tuesday 13 January 2004 at 4:00 p.m. - Main Auditorium (bldg. 500) to convey my best wishes for the new year and to present a perspective of CERN's future activities. Closed-circuit transmission of the meeting will be available in the Council Chamber and in the AB Auditorium (Meyrin), the AB Auditorium (Prévessin), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). A simultaneous translation into English will be available in the main Auditorium. Robert AYMAR

  2. Public meetings

    CERN Multimedia

    Staff Association

    2014-01-01

      Public meetings : Come and talk about your future employment conditions !   The Staff Association will come and present the results of our survey on the 2015 five-yearly review. Following the survey, the topics discussed, will be contract policy, recognition of merit (MARS), working time arrangements and family policy. After each meeting and around a cup of coffee or tea you will be able to continue the discussions. Do not hesitate to join us, the five-yearly review, it is with YOU!

  3. ACCU Meeting

    CERN Multimedia

    PH Department

    2011-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 15 June 2011 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department Update on Safety at CERN Reports from ACCU representatives on other Committees a. Scientific Information Policy Board (SIPB) b. IT Service Review Meeting (ITSRM) c. GS User Commission Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in bra...

  4. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 4 December 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Fellows, Associates and Summer Student Programmes Particle Data Book distribution Revoking Computer accounts Equipment insurance on site Reports from ACCU representatives on other committees Users' Office news Any Other Business Dates for meetings in 2003 Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (74837...

  5. ACCU MEETING

    CERN Multimedia

    Chris Onions (Secretary)

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria  W. Adam  (71661) Belgium  G. Wilquet  (74664) Bulgaria  R. Tzenov  (77958) Czech Republic  P. Závada&am...

  6. ACCU MEETING

    CERN Multimedia

    Chris Onions (Secretary)

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meetingAnyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiiskinen (79387) Fr...

  7. ACCU MEETING

    CERN Multimedia

    Chris Onions (Secretary)

    2000-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 December 2000 At 10 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Equal Opportunities at CERN The Summer Student programme CERN Programme for Physics High School Teachers Users' Office News Any Other Business Dates for Meetings in 2001 Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) : Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Re...

  8. ACCU MEETING

    CERN Multimedia

    2000-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 December 2000 At 10 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Equal Opportunities at CERN The Summer Student programme CERN Programme for Physics High School Teachers Users' Office News Any Other Business Dates for Meetings in 2001 Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) :   Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958)...

  9. Crisis meeting

    CERN Multimedia

    Staff Association

    2014-01-01

      To all CERN staff: your rights are at risk ! We invite you to come to a crisis meeting on Wednesday 2nd April at 10:30 a.m., Auditorium, Main Building, Meyrin site. Your presence is crucial, we are ALL concerned !

  10. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 4 December 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Fellows, Associates and Summer Student Programmes Particle Data Book distribution Revoking Computer accounts Equipment insurance on site Reports from ACCU representatives on other committees Users' Office news Any Other Business Dates for meetings in 2003 Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (74837...

  11. Crisis meeting

    CERN Multimedia

    Staff Association

    2015-01-01

    To all CERN staff: your rights are at risk! We invite you to come to a crisis meeting on Thursday 7th May 2015 at 9 a.m., Auditorium, Main Building, Meyrin site. Your presence is crucial, we are ALL concerned!

  12. Nice to meet you: genetic, epigenetic and metabolic controls of plant perception of beneficial associative and endophytic diazotrophic bacteria in non-leguminous plants.

    Science.gov (United States)

    Carvalho, T L G; Ballesteros, H G F; Thiebaut, F; Ferreira, P C G; Hemerly, A S

    2016-04-01

    A wide range of rhizosphere diazotrophic bacteria are able to establish beneficial associations with plants, being able to associate to root surfaces or even endophytically colonize plant tissues. In common, both associative and endophytic types of colonization can result in beneficial outcomes to the plant leading to plant growth promotion, as well as increase in tolerance against biotic and abiotic stresses. An intriguing question in such associations is how plant cell surface perceives signals from other living organisms, thus sorting pathogens from beneficial ones, to transduce this information and activate proper responses that will finally culminate in plant adaptations to optimize their growth rates. This review focuses on the recent advances in the understanding of genetic and epigenetic controls of plant-bacteria signaling and recognition during beneficial associations with associative and endophytic diazotrophic bacteria. Finally, we propose that "soil-rhizosphere-rhizoplane-endophytes-plant" could be considered as a single coordinated unit with dynamic components that integrate the plant with the environment to generate adaptive responses in plants to improve growth. The homeostasis of the whole system should recruit different levels of regulation, and recognition between the parties in a given environment might be one of the crucial factors coordinating these adaptive plant responses.

  13. TRANSLATING ECOLOGY, PHYSIOLOGY, BIOCHEMISTRY, AND POPULATION GENETICS RESEARCH TO MEET THE CHALLENGE OF TICK AND TICK-BORNE DISEASES IN NORTH AMERICA.

    Science.gov (United States)

    Esteve-Gassent, Maria D; Castro-Arellano, Ivan; Feria-Arroyo, Teresa P; Patino, Ramiro; Li, Andrew Y; Medina, Raul F; de León, Adalberto A Pérez; Rodríguez-Vivas, Roger Iván

    2016-05-01

    Emerging and re-emerging tick-borne diseases threaten public health and the wellbeing of domestic animals and wildlife globally. The adoption of an evolutionary ecology framework aimed to diminish the impact of tick-borne diseases needs to be part of strategies to protect human and animal populations. We present a review of current knowledge on the adaptation of ticks to their environment, and the impact that global change could have on their geographic distribution in North America. Environmental pressures will affect tick population genetics by selecting genotypes able to withstand new and changing environments and by altering the connectivity and isolation of several tick populations. Research in these areas is particularly lacking in the southern United States and most of Mexico with knowledge gaps on the ecology of these diseases, including a void in the identity of reservoir hosts for several tick-borne pathogens. Additionally, the way in which anthropogenic changes to landscapes may influence tick-borne disease ecology remains to be fully understood. Enhanced knowledge in these areas is needed in order to implement effective and sustainable integrated tick management strategies. We propose to refocus ecology studies with emphasis on metacommunity-based approaches to enable a holistic perspective addressing whole pathogen and host assemblages. Network analyses could be used to develop mechanistic models involving multihost-pathogen communities. An increase in our understanding of the ecology of tick-borne diseases across their geographic distribution will aid in the design of effective area-wide tick control strategies aimed to diminish the burden of pathogens transmitted by ticks. © 2016 Wiley Periodicals, Inc.

  14. Modifiable etiological factors and the burden of stroke from the Rotterdam study: a population-based cohort study.

    Directory of Open Access Journals (Sweden)

    Michiel J Bos

    2014-04-01

    Full Text Available BACKGROUND: Stroke prevention requires effective treatment of its causes. Many etiological factors for stroke have been identified, but the potential gain of effective intervention on these factors in terms of numbers of actually prevented strokes remains unclear because of the lack of data from cohort studies. We assessed the impact of currently known potentially modifiable etiological factors on the occurrence of stroke. METHODS AND FINDINGS: This population-based cohort study was based on 6,844 participants of the Rotterdam Study who were aged ≥55 y and free from stroke at baseline (1990-1993. We computed population attributable risks (PARs for individual risk factors and for risk factors in combination to estimate the proportion of strokes that could theoretically be prevented by the elimination of etiological factors from the population. The mean age at baseline was 69.4 y (standard deviation 6.3 y. During follow-up (mean follow-up 12.9 y, standard deviation 6.3 y, 1,020 strokes occurred. The age- and sex-adjusted combined PAR of prehypertension/hypertension, smoking, diabetes mellitus, atrial fibrillation, coronary disease, and overweight/obesity was 0.51 (95% CI 0.41-0.62 for any stroke; hypertension and smoking were the most important etiological factors. C-reactive protein, fruit and vegetable consumption, and carotid intima-media thickness in combination raised the total PAR by 0.06. The PAR was 0.55 (95% CI 0.41-0.68 for ischemic stroke and 0.70 (95% CI 0.45-0.87 for hemorrhagic stroke. The main limitations of our study are that our study population comprises almost exclusively Caucasians who live in a middle and high income area, and that risk factor awareness is higher in a study cohort than in the general population. CONCLUSIONS: About half of all strokes are attributable to established causal and modifiable factors. This finding encourages not only intervention on established etiological factors, but also further study of less

  15. Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study.

    Science.gov (United States)

    Yazdanpanah, Nahid; Zillikens, M Carola; Rivadeneira, Fernando; de Jong, Robert; Lindemans, Jan; Uitterlinden, André G; Pols, Huibert A P; van Meurs, Joyce B J

    2007-12-01

    A mildly elevated homocysteine (Hcy) level is a novel and potentially modifiable risk factor for age-related osteoporotic fractures. Elevated Hcy levels can have a nutritional cause, such as inadequate intake of folate, riboflavin, pyridoxine or cobalamin, which serve as cofactors or substrates for the enzymes involved in the Hcy metabolism. We examined the association between intake of Hcy-related B vitamin (riboflavin, pyridoxine, folate and cobalamin) and femoral neck bone mineral density BMD (FN-BMD) and the risk of fracture in a large population-based cohort of elderly Caucasians. We studied 5304 individuals aged 55 years and over from the Rotterdam Study. Dietary intake of nutrients was obtained from food frequency questionnaires. Incident non-vertebral fractures were recorded during a mean follow-up period of 7.4 years, and vertebral fractures were assessed by X-rays during a mean follow-up period of 6.4 years. We observed a small but significant positive association between dietary pyridoxine (beta = 0.09, p = 1 x 10(-8)) and riboflavin intake (beta = 0.06, p = 0.002) and baseline FN-BMD. In addition, after controlling for gender, age and BMI, pyridoxine intake was inversely correlated to fracture risk. As compared to the three lowest quartiles, individuals in the highest quartile of age- and energy-adjusted dietary pyridoxine intake had a decreased risk of non-vertebral fractures (HR = 0.77, 95% CI = 0.65-0.92, p = 0.005) and of fragility fractures (HR = 0.55, 95% CI = 0.40-0.77, p = 0.0004). Further adjustments for other dietary B vitamins (riboflavin, folate and cobalamin), dietary intake of calcium, vitamin D, vitamin A and vitamin K, protein and energy intake, smoking and BMD did not essentially modify these results. We conclude that increased dietary riboflavin and pyridoxine intake was associated with higher FN-BMD. Furthermore, we found a reduction in risk of fracture in relation to dietary pyridoxine intake independent of BMD. These findings

  16. Genetic Research Methodology Meets Early Childhood Science Education Research: A Cultural-Historical Study of Child’s Scientific Thinking Development

    Directory of Open Access Journals (Sweden)

    Fragkiadaki G.,

    2016-12-01

    Full Text Available The study reported in this paper aims to structure a cultural-historical understanding on how early childhood children experience science and how they develop scientific thinking as they interact with the social, cultural and material world. Moving beyond the cognitive dimensions of learning by interrelating different aspects of the process of children’s scientific thinking development constitutes a research prior- ity for the study. From a wide range of collected data, in the present article one qualitative empirical case study is presented. The detailed single example that is analyzed refers to a kindergarten female student, aged 5.2 years old, from an urban area of Greece. A developmental research methodology as specified from the requirements of cultural-historical theory framework is used. Following four of the main principles of the experimental genetic method, this study creates a fecund ground for a cultural-historical exploration and interpretation of the very processes of the child’s development. The collection of the data was achieved through expanded, open-type conversations conducted at three concrete phases between the case study child, two of her peers and the educator. Drawing upon the system of theoretical concepts of cultural- historical theory the analysis is mainly based on the concept of perezhivanie as analytical tool as well as the concept of the developmental trajectories. The concept of the conceptualization of a precursor model as a theoretical tool that derives from the field of Science Education is also used. The analysis gives insights into how a certain social situation between children and educators in kindergarten settings becomes the unique social situation of a child’s development. Using as a base the dialectic perspective that Vygotsky posed in the analysis of human psyche, the study in this paper offers a creative insight in order to elaborate on a broad and dynamic understanding of the child

  17. Staff meeting

    CERN Multimedia

    2007-01-01

    I would like to invite all members of the CERN Personnel to a meeting on Wednesday 16 January 2008 at 3:00 p.m. Main Auditorium (bldg 500) to convey my best wishes for the new year, to review CERN’s activities during 2007 and to present the perspectives for 2008, the year of the LHC start-up. Closed-circuit transmission of the meeting will be available in the Council Chamber and in the AB Auditorium (Meyrin), the AB Auditorium (Prévessin), the IT Auditorium (Bldg. 31) and the AT Auditorium (Bldg. 30). Simultaneous translation into English will be available in the main Auditorium. Best wishes for the festive season! Robert AYMAR

  18. Public meetings

    CERN Multimedia

    Staff Association

    2012-01-01

    MARS PENSIONS CONTRACT POLICY GENERAL INFORMATION   PUBLIC MEETINGS COME AND BE INFORMED! Public meetings Monday 15 Oct. 2 pm Amphi IT, 31-3-004 Meyrin Wednesday 17 Oct. 10 am Amphi BE, 864-1-D02 Prévessin Thursday 18 Oct. 10 am Salle du Conseil/ Council Chamber 503-1-001 Meyrin Thursday 18 Oct. 2 pm Filtration Plant, 222-R-001(in English) Meyrin   Overview of the topics to be discussed Recognition of Merit – MARS Outcome of last exercise 2007 to 2012 : lessons learned Pension Fund Capital preservation policy : what is it ? Contract policy LC2IC statistics SA proposal General information CVI 2013 Voluntary programmes (PRP, SLS)  

  19. ACCU Meeting

    CERN Document Server

    Chris Onions

    2005-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 March 2005 At 9:15 a.m. in room 160-1-009 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Purchasing procedures at CERN Reports from ACCU representatives on other committees Users' Office news CERN Clubs Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Las...

  20. ACCU Meeting

    CERN Multimedia

    PH Department

    2008-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 11 June 2008 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN Childcare initiative Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria - W. Adam (71661) Belgium - C. Vander Velde (71539) Bulgaria Czech Republic - P. Závada (75877) Denmark - J.B. Hansen...

  1. ACCU MEETING

    CERN Multimedia

    PH Department

    2009-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 June 2009At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management CERN Social Services User services in GS Department An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria - G. Walzel (76592) Belgium - C. Vander Velde (71539) Bulgaria Czech Republic - P. Závada (7587...

  2. ACCU MEETING

    CERN Multimedia

    PH Department

    2008-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 September 2008 At 9:15 a.m. in Room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria, W. Adam (71661) Belgium, C. Vander Velde (71539) Bulgaria Czech Republic, P. Závada (75877) Denmark, J.B. Hansen (...

  3. ACCU MEETING

    CERN Multimedia

    PH Department

    2010-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 March 2010 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives on ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium C. Vander Velde (Chairperson) (71539) Bulgaria Czech Republic S. Nemecek (71144) ...

  4. ACCU MEETING

    CERN Multimedia

    PH Department

    2009-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 11 March 2009 At 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks 2.\tAdoption of the agenda 3.\tMinutes of the previous meeting 4.\tMatters arising 5.\tNews from the CERN Management 6.\tThe CERN Press Office 7.\tAn update on Safety at CERN 8.\tThe Burotel project 9.\tReports from ACCU representatives on other committees 10.\tUsers’ Office news 11.\tAny Other Business 12.\tAgenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel () Belgium C. Vander Velde (71539) Bulgaria C...

  5. ACCU MEETING

    CERN Multimedia

    PH Department

    2009-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 September 2009 At 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks 2.\tAdoption of the agenda 3.\tMinutes of the previous meeting 4.\tMatters arising 5.\tNews from the CERN Management 6.\tCode of conduct 7.\tEqual Opportunities at CERN 8.\tAn update on safety at CERN 9.\tThe CERN shuttle service 10.\tReports from ACCU representatives on other committees 11.\tUsers’ Office news 12.\tOther business 13.\tAgenda of the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives on ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium C. Vander Velde (71539) Bulgaria Czech Re...

  6. ACCU MEETING

    CERN Multimedia

    PH Department

    2009-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 11 March 2009 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management The CERN Press Office An update on Safety at CERN The Burotel project Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel () Belgium C. Vander Velde (71539) Bulgaria Czech Republic P. Závada (75877) Denmark...

  7. ACCU MEETING

    CERN Multimedia

    PH Department

    2008-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 3 December 2008 at 9:15 a.m. in Room 60-6-002 1.\tChairman’s remarks 2.\tAdoption of the agenda 3.\tMinutes of the previous meeting 4.\tMatters arising 5.\tNews from the CERN Management 6.\tReport from the new Director-General 7.\tReport on the Fellows and Associates programme 8.\tAn update on Safety at CERN 9.\tReports from ACCU representatives on other committees 10.\tUsers’ Office news 11.\tAny Other Business 12.\tAgenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium C. ...

  8. ACCU Meeting

    CERN Multimedia

    Chris Onions

    DRAFT Agenda for the meeting to be held on Wednesday 9 December 2009 At 9:15 a.m. in Room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Restaurant No. 1 extension An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Election of the ACCU Chair Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium C. Vander Velde (71539) Bulgaria Czech Republic P. Záv...

  9. ACCU MEETING

    CERN Multimedia

    PH Department

    2008-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 11 June 2008 At 9:15 a.m. in Room 60-6-002 1.\tChairman’s remarks 2.\tAdoption of the agenda 3.\tMinutes of the previous meeting 4.\tMatters arising 5.\tNews from the CERN Management 6.\tAn update on safety at CERN 7.\tChildcare initiative 8.\tReports from ACCU representatives on other committees 9.\tUsers’ Office news 10.\tAny Other Business 11.\tAgenda for the next meeting Anyone wishing to raise any points under Item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium C. Vander Velde (71539) Bulgaria Czech Republic P. Závada (75...

  10. ACCU MEETING

    CERN Multimedia

    PH Department

    2009-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 September 2009 At 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks 2.\tAdoption of the agenda 3.\tMinutes of the previous meeting 4.\tMatters arising 5.\tNews from the CERN Management 6.\tCode of Conduct 7.\tEqual Opportunities at CERN 8.\tAn update on Safety at CERN 9.\tThe CERN shuttle service 10.\tReports from ACCU representatives on other committees 11.\tUsers’ Office news 12.\tAny Other Business 13.\tAgenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium C. Vander Velde (71539) Bulgaria Cze...

  11. ACCU MEETING

    CERN Multimedia

    PH Department

    2011-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 7 September 2011 at 9:15 a.m. in room 60-6-002   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting Matters arising       News from the CERN Management Report on services from GS department Report on new CHIS rules Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria M. Jeitler (76307) Belgium C. Vander Velde (Chairperson)...

  12. ACCU MEETING

    CERN Multimedia

    2003-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 December 2003 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 8. Report from IT division on Computing matters 2. Adoption of the agenda 9. Young Particle Physicists Association 3. Minutes of the previous meeting 10. Reports from ACCU representatives on other committees 4. Matters arising 11. Users' Office news 5. News from the CERN Management 12. Election of the ACCU Chair 6. Report from the new Director-General 13. Any Other Business 7. CERN's 50th anniversary 14. Agenda for the next meeting Anyone wishing to raise any points under item 13 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (716...

  13. ACCU MEETING

    CERN Multimedia

    2003-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 March 2003 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 7. Equipment insurance on site 2. Adoption of the agenda 8. ACCU reporting mechanisms in the different countries 3. Minutes of the previous meeting 9. Reports from ACCU representatives on other committees 4. Matters arising 10. Users' Office news 5. News from the CERN Management 11. Any Other Business 6. Health Insurance news and follow-up of survey 12. Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Norway H. Helstrup (73601) Belgium G. Wil...

  14. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 March 2002 At 9:15 a.m. in the Council Chamber Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Follow-up on Space Management Users' Desktop needs PIE procedures Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland E. Tuominen (71534) France F. Bauer L. Serin (712...

  15. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 12 June 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management PIE procedures CERN Cars EP Electronics Advisory Board Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland E. Tuominen (71534) France F. Bauer (71247) L. Serin (71143) Germany H. Kroha...

  16. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 12 June 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management PIE procedures CERN Cars EP Electronics Advisory Board Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland E. Tuominen (71534) France F. Bauer (71247) L. Serin (71143) Germany H. Kroha ...

  17. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 March 2004 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting News from the CERN Management Matters arising The PH Department Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark P. Hansen (75941) Finland E. Tuominen (71534) France F. Bauer (71247) L. Serin...

  18. ACCU MEETING

    CERN Multimedia

    2003-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 December 2003 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 8. Report from IT division on Computing matters 2. Adoption of the agenda 9. Young Particle Physicists Association 3. Minutes of the previous meeting 10. Reports from ACCU representatives on other committees 4. Matters arising 11. Users' Office news 5. News from the CERN Management 12. Election of the ACCU Chair 6. Report from the new Director-General 13. Any Other Business 7. CERN's 50th anniversary 14. Agenda for the next meeting Anyone wishing to raise any points under item 13 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Ada...

  19. ACCU Meeting

    CERN Multimedia

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 March 2004 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 6. The PH Department 2. Adoption of the agenda 7. Reports from ACCU representatives on other committees 3. Minutes of the previous meeting 8. Users' Office news 4. News from the CERN Management 9. Any Other Business 5. Matters arising 10. Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Norway H. Helstrup (73601) Belgium G. Wilquet (74664) Poland Z. Hajduk (75917) Bulgaria R. Tsenov (79573) Portugal P. Bordalo (74704) Czech Republic P. Závada ...

  20. ACCU MEETING

    CERN Multimedia

    2003-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 11 June 2003 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 7. Reports from ACCU representatives 2. Adoption of the agenda on other committees 3. Minutes of the previous meeting 8. Users' Office news 4. Matters arising 9. Any Other Business 5. News from the CERN Management 10. Agenda for the next meeting 6. Property Protection at CERN Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Norway H. Helstrup (73601) Belgium G. Wilquet (74664) Poland Z. Hajduk (75917) Bulgaria R. Tsenov (74837) Portugal P. Bordalo (74704) Czech Republic ...

  1. ACCU MEETING

    CERN Multimedia

    2003-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 March 2003 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 7. Equipment insurance on site 2. Adoption of the agenda,8. ACCU reporting mechanisms in the different countries 3. Minutes of the previous meeting9. Reports from ACCU representatives on other committees 4. Matters arising10. Users' Office news 5. News from the CERN Management11. Any Other Business 6. CHIS news and follow-up of survey12. Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661)NorwayH. Helstrup (73601) Belgium G. Wilquet (74664) Poland Z. Hajduk (7591...

  2. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 11 September 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Health Insurance Questionnaire Host States Relations Service Update on EP Space management Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland E. Tuominen (71534) France F. Bauer (71247) L. Serin (...

  3. ACCU Meeting

    CERN Multimedia

    2003-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 September 2003 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 8. Registration plans for portables 2. Adoption of the agenda 9. Reports from ACCU representatives 3. Minutes of the previous meeting on other committees 4. Matters arising 10. Users' Office news 5. News from the CERN Management 11. Any Other Business 6. The Press Office 12. Agenda for the next meeting 7. Equal Opportunities Commission Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): AustriaW. Adam (71661) Norway H. Helstrup (73601) Belgium G. Wilquet (74664) Poland Z. Hajduk (75917) Bulgari...

  4. ACCU Meeting

    CERN Multimedia

    2003-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 September 2003 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 7. Equal Opportunities Commission 2. Adoption of the agenda 8. Registration plans for portables 3. Minutes of the previous meeting 9. Reports from ACCU representatives on other committees 4. Matters arising 10. Users' Office news 5. News from the CERN Management 11. Any Other Business 6. The Press Office 12. Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Norway H. Helstrup (73601) Belgium G. Wilquet (74664) Poland Z. Hajduk (75917) Bulgar...

  5. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 September 2004 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management The Visits Service Lifetime of Computer Accounts Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark P. Hansen (75941) Finland K. Lassila-Perini (79354) France F. Bauer (...

  6. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2005-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 March 2005 At 9:15 a.m. in room 160-1-009 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Purchasing procedures at CERN Reports from ACCU representatives on other committees Users' Office news CERN Clubs Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Las...

  7. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2005-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 June 2005 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Logistics at CERN Open Access Publishing Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Lassila-Perini ...

  8. ACCU MEETING

    CERN Multimedia

    2006-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 September 2006 at 9:15 a.m. in room 60-6-002 1.     Chairman's remarks 2.     Adoption of the agenda 3.     Minutes of the previous meeting 4.     Matters arising 5.     News from the CERN Management 6.     Report on Fellows and Associates programme 7.     Overview of safety at CERN 8.     Reports from ACCU representatives on other committees 9.     Users' Office news 10.  Any Other Business 11.  Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets):Austria W. Adam  (71661) Belgium G. Wilquet (74664) Bulgaria ...

  9. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2005-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 7 September 2005 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Logistics at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Lassila-Perini (79354) France F. Bauer S. Laplace...

  10. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 December 2004 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting The effects of the reorganization of CERN's structure, one year on Matters arising News from the CERN Management Computer Security The new CERN Dosimeter Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark P. Hansen (7594...

  11. ACCU MEETING

    CERN Multimedia

    2006-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 December 2006 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Safety at CERN Car sharing pilot project CERN Public Web Sites and Intranet Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria   Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finl...

  12. ACCU MEETING

    CERN Multimedia

    Chris Onions/EP (Secretary)

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 June 2001 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising EP Space management Cars Housing EDH from the User's point of view VRVS Users' Office News Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiiskinen (79387) France M. Déj...

  13. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2006-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 14 June 2006 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Car sharing pilot project The CERN Document Server : the portal to Open Access Videoconferencing and collaborative tools at CERN Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (7...

  14. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 September 2004 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management The Visits Service Lifetime of Computer Accounts Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark P. Hansen (75941) Finland K. Lassila-Perini (79354) France F. Bauer (7...

  15. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2006-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 14 June 2006 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Car sharing pilot project The CERN Document Server : the portal to Open Access Videoconferencing and collaborative tools at CERN Reports from ACCU representatives on other committees Users'Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) ...

  16. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 December 2004 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting The effects of the reorganization of CERN's structure, one year on Matters arising News from the CERN Management Computer Security The new CERN Dosimeter Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark P. Hansen (75941) Finl...

  17. ACCU MEETING

    CERN Multimedia

    Chris Onions (Secretary)

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 12 September 2001 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Logistics and Self-service stores EP Space management follow-up How to improve IT User Support? Users' Office News Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Roger.Jones@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiiskin...

  18. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2006-01-01

    DRAFT Agenda of the meeting to be held on Wednesday 8 March 2006 At 9:15 a.m. in Room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Proposal for a centralised access control service Report from PH Space Management Policy Board Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under Item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives on ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) ...

  19. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2005-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 7 December 2005 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Closure of computer accounts upon CERN contract expiry Reports from ACCU representatives on other committees Users' Office news Election of ACCU Chair Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets). Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) ...

  20. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 7 March 2001 At 9:15 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Video-conferencing/recording Fellows programme Operational Circular No. 6 EP Space management Update on Computing Issues Users' Office News Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary)  ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic...

  1. ACCU MEETING

    CERN Multimedia

    PH Department

    2008-01-01

    DRAFT Agenda for the meeting to be heldon Wednesday 5 March 2008 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN The CERN Ombudsperson proposal Childcare initiative Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) BelgiumnC. Vander Velde (71539) Bulgaria Czech Republic P. Závada (75877) Denm...

  2. ACCU Meeting

    CERN Multimedia

    2006-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 December 2006 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Safety at CERN Car sharing pilot project CERN Public Web Sites and Intranet Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria   Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finl...

  3. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 13 June 2007 at 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Dosimetry at CERN Status of collaborative tools at CERN Reports from ACCU representatives on other committees Users' Office newss Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Lassila-Perini (7935...

  4. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 June 2004 at 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Update on CERN's 50th anniversary celebrations Report from the EPOG (European Particle Physics Outreach Group) Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark P. Hansen (75941...

  5. ACCU MEETING

    CERN Multimedia

    2006-01-01

    DRAFT Agenda of the meeting to be held on Wednesday 6 September 2006 at 9:15 a.m. in Room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on Fellows and Associates Programme Overview of safety at CERN Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under Item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K....

  6. ACCU MEETING

    CERN Multimedia

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 13 June 2007 at 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks 6.\tDosimetry at CERN 2.\tAdoption of the agenda 7.\tStatus of collaborative tools at CERN 3.\tMinutes of the previous meeting 8.\tReports from ACCU representatives on other committees 4.\tMatters arising 9.\tUsers’ Office newss 5.\tNews from the CERN Management 10.\tAny Other Business 11.\tAgenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Norway G. Løvhøiden (73176) Belgium G. Wilquet (74664) Poland M. Witek (78967) Bulgaria Portugal...

  7. ACCU Meeting

    CERN Multimedia

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 7 March 2007 at 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Car-sharing pilot project Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Lassila-Perini (79354) France F. Kunne S. La...

  8. ACCU Meeting

    CERN Multimedia

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 7 March 2007 at 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Car-sharing pilot project Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Lassila-Perini (79354) France F. Kunne S. ...

  9. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2006-01-01

    DRAFT Agendafor the meeting to be held on Wednesday 8 March 2006At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Proposal for a centralised access control service Report from PH Space Management Policy Board Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Fin...

  10. ACCU MEETING

    CERN Multimedia

    Chris Onions (Secretary)

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 June 2001 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Logistics and Self-service stores EP Space management follow-up How to improve IT User Support? Users' Office News Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Roger.Jones@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiis...

  11. ACCU Meeting

    CERN Multimedia

    Chris Onions

    2004-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 June 2004 at 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Update on CERN's 50th anniversary celebrations Report from the EPOG (European Particle Physics Outreach Group) Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark P. Hansen (75941) Finlan...

  12. ACCU meeting

    CERN Multimedia

    PH Department

    2008-01-01

    DRAFT Agenda for the meeting to be heldon Wednesday 5 March 2008 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN The CERN Ombudsperson proposal Childcare initiative Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) BelgiumnC. Vander Velde (71539) Bulgaria Czech Republic P. Závada (75877) Denm...

  13. ACCU meeting

    CERN Multimedia

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 December 2007 At 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks 2.\tAdoption of the agenda 3.\tMinutes of the previous meeting 4.\tMatters arising 5.\tNews from the CERN Management 6.\tLHC 2008 start-up events 7.\tEmergency Services at CERN 8.\tThe Meyrin Tram project 9.\tReports from ACCU representatives on other committees 10.\tUsers’ Office news 11.\tElection of ACCU Chair 12.\tAny Other Business 13.\tAgenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilq...

  14. ACCU MEETING

    CERN Multimedia

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 December 2007 at 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks7.\tEmergency Services at CERN 2.\tAdoption of the agenda\t8.\tThe Meyrin Tram project 3.\tMinutes of the previous meeting9.\tReports from ACCU representatives on other committees 4.\tMatters arising10.\tUsers’ Office news 5.\tNews from the CERN Management11.\tElection of ACCU Chair 6. LHC 2008 start-up events 6.\tLogistics and transport at CERN 12.\tAny Other Business 13.\tAgenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Aust...

  15. ACCU MEETING

    CERN Multimedia

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 12 September 2007 at 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks6.\tLogistics and transport at CERN2.\tAdoption of the agenda\t7.\tCar sharing pilot project3.\tMinutes of the previous meeting8.\tReports from ACCU representatives on other committees4.\tMatters arising9.\tUsers’ Office newss5.\tNews from the CERN Management10.\tAny Other Business11.\tAgenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria\tW. Adam (71661)NorwayG. Løvhøiden (73176)Belgium\tG. Wilquet (74664)PolandM. Witek (78967)Bulgaria\tPortugalP...

  16. ACCU MEETING

    CERN Multimedia

    2007-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 12 September 2007 at 9:15 a.m. in room 60-6-002 1.\tChairman’s remarks7.\tCar sharing pilot project 2.\tAdoption of the agenda\t8.\tReports from ACCU representatives on other committees 3.\tMinutes of the previous meeting9.\tUsers’ Office newss 4.\tMatters arising10.\tAny Other Business 5.\tNews from the CERN Management11.\tAgenda for the next meeting 6.\tLogistics and transport at CERN Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria\tW. Adam (71661)NorwayG. Løvhøiden (73176)Belgium\tG. Wilquet (74664)PolandM. Witek (78967)...

  17. ACCU MEETING

    CERN Multimedia

    2000-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 13 September 2000 At 10 a.m. in the 6th floor Conference Room, Main Building 1. Chairman's remarks 2. Adoption of the agenda 3. News from the CERN Management 4. Minutes of the previous meeting 5. Matters arising 6. Report from the Scientific Information Policy Board 7. Report from ETT Division: The Press Office 8. Update on Computing Issues 9. Users' Office News 10. Any Other Business 11. Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Bryan Pattison (Secretary). ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) : Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Z vada (75...

  18. ACCU MEETING

    CERN Multimedia

    Bryan Pattison

    2000-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 13 September 2000 At 10 a.m. in the 6th floor Conference Room, Main Building1. Chairman's remarks2. Adoption of the agenda3. News from the CERN Management4. Minutes of the previous meeting5. Matters arising6. Report from the Scientific Information Policy Board7. Report from ETT Division: The Press Office8. Update on Computing Issues9. Users' Office News10. Any Other Business11. Agenda for the next meetingAnyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail toBryan Pattison(Secretary).ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) :Austria G. Neuhofer (74094)Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958)Czech Republic P. Závada (75877)Den...

  19. ACCU MEETING

    CERN Multimedia

    Chris Onions / EP Division

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 June 2001 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising EP Space management Cars Housing EDH from the User's point of view VRVS Users' Office News Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiiskinen (79387) France M. Déj...

  20. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 March 2002 At 9:15 a.m. in the Council Chamber Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Follow-up on Space Management Users' Desktop needs PIE procedures Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland E. Tuominen (71534) France F. Bauer L. Serin (712...

  1. ACCU MEETING

    CERN Multimedia

    PH Department

    2009-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 10 June 2009At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management CERN Social Services User services in GS Department An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria - G. Walzel (76592) Belgium - C. Vander Velde (71539) Bulgaria Czech Republic - P. Závada (7587...

  2. Genetics and molecular biology of breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

    1992-12-31

    This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

  3. Staff meeting

    CERN Multimedia

    2007-01-01

    Dear Colleagues, 2007 is a very special year for CERN. I would like to review the status of our activities with you, and I invite you to a presentation on Wednesday 27 June 2007 at 3:00 p.m. Main Auditorium (bldg. 500) Closed-circuit transmission of the meeting will be available in the Council Chamber and in the AB Auditorium (Meyrin), the AB Auditorium (Prévessin), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). Simultaneous translation into English will be available in the Main Auditorium. Robert AYMAR

  4. Public meetings

    CERN Multimedia

    Staff Association

    2014-01-01

      MARS 2015 FIVE YEARLY REVIEW CONTRACT POLICY PENSION FUND GENERAL INFORMATION   COME AND BE INFORMED! PUBLIC MEETINGS Friday 3rd October at 10 am Amphi BE, 864-1-D02 Prévessin Friday 3rd October at 2 pm Salle du Conseil / Council Chamber, 503-1-001 (in English) Meyrin Monday 6th October at 10 am Kjell Johnsen Auditorium, 30-7-018 Meyrin Monday 6th October at 2 pm Salle du Conseil / Council Chamber, 503-1-001 Meyrin  

  5. Centro comercial, Rotterdam

    Directory of Open Access Journals (Sweden)

    Van den Broek y Bakema, Arquitectos

    1960-10-01

    Full Text Available Este importante centro comercial está emplazado en el centro de la ciudad, en un barrio afectado por los bombardeos de la pasada guerra mundial y, actualmente, en reconstrucción acelerada. Consta, fundamentalmente, de seis bloques paralelos dos a dos, que forman una avenida en ángulo recto, con pasos cubiertos de comunicación transversal que cumplen la doble misión: guarecer de la lluvia a los viandantes que pasan de una a otra parte y de romper la monotonía longitudinal, mediante estos esbeltos y transparentes elementos funcionales. La avenida está exclusivamente reservada a los peatones, sin acceso rodado, y se completará, en una segunda fase constructiva, con otros edificios similares y grandes edificios de oficinas.

  6. ACCU MEETING

    CERN Multimedia

    PH Department

    2008-01-01

    DRAFT Agenda for the meetingto be held on Wednesday 3 December 2008 at 9:15 a.m.in Room 60-6-002 1.\tChairman’s remarks 2.\tAdoption of the agenda 3.\tMinutes of the previous meeting 4.\tMatters arising 5.\tNews from the CERN Management 6.\tReport from the new Director-General 7.\tReport on the Fellows and Associates programme 8.\tAn update on Safety at CERN 9.\tReports from ACCU representatives on other committees 10.\tUsers’ Office news 11.\tAny Other Business 12.\tAgenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium C. Va...

  7. ESST Proceedings Rotterdam 2009. Beet Quality. Sustainability of beet sugar production. Energy usage - future challenges. General process technology developments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Within the conference of the European Society for Sugar Technology (Berlin, Federal Republic of Germany) between 17th and 20th June, 2009 in Rotterdam (The Netherlands) the following lectures were held: (1) Sugar beet quality during long-term storage in clamp and field (A.W.M. Huijbregts); (2) Methods used in the Netherlands to limit frost damage and to process frost-deteriorated beets (J. Strujis, M. Jaspers, M. van Dijk); (3) Biotech in sugarbeet and sugarcane: Current status (T.K. Schwartz, C. Richard); (4) Separation of water through gas hydrate (T. Boech Andersen); (5) Optimised standard of sugar manufacturing - first calculations (F. Lorenz, T. Frankenfeld); (6) Reconsidering vapour compression for sugar crystallization (A. Dolls, M. Bruhns); (7) The development of sustainability standards in the sugar industry (P. Rein); (8) Bioethanol: sugar beet, sugar cane or second generation? (W.J. Corre, J.G. Conijin); (9) The sustainability of beet sugar production in comparison with other sugar crops (P. Christodoulou, V. Kazantzi, S. Bezergianni, K. Gounaris); (10) Alternative products from sugar beets (J. Iciek, S. Wawro); (11) Alternative products from sugar beets (M. Wojtczak); (12) Increase of sugar yield by electrodialysis (J.P. Jenen, P.B. Hansen, M.P. Carter); (13) Optimal dosing of alkalizing agents in the juice purification (G. Roesner, W. Hein, F. Emerstorfer); (14) Affinity based separation technologies and their role in the current and future sugar industry (V. Kochergin); (15) Four to three-stage sugarhouse with two white sugar products (J. Jeppesen, M. Carter); (16) Practical experience of juice decalcification using a weak acid cation exchange resin plant incorporating fractal fluid distribution (E. West, P. Burroughs, P. Seymour); (17) A new process for the production of 'seed crystals' - Process development and field report from the factories (M. Walter, B. Ekelhof, S. Heppner, D. Wullbrandt); (18) Application possibilities and Properties

  8. Meeting Venus

    Science.gov (United States)

    Sterken, Christiaan; Aspaas, Per Pippin

    2013-06-01

    On 2-3 June 2012, the University of Tromsoe hosted a conference about the cultural and scientific history of the transits of Venus. The conference took place in Tromsoe for two very specific reasons. First and foremost, the last transit of Venus of this century lent itself to be observed on the disc of the Midnight Sun in this part of Europe during the night of 5 to 6 June 2012. Second, several Venus transit expeditions in this region were central in the global enterprise of measuring the scale of the solar system in the eighteenth century. The site of the conference was the Nordnorsk Vitensenter (Science Centre of Northern Norway), which is located at the campus of the University of Tromsoe. After the conference, participants were invited to either stay in Tromsoe until the midnight of 5-6 June, or take part in a Venus transit voyage in Finnmark, during which the historical sites Vardoe, Hammerfest, and the North Cape were to be visited. The post-conference program culminated with the participants observing the transit of Venus in or near Tromsoe, Vardoe and even from a plane near Alta. These Proceedings contain a selection of the lectures delivered on 2-3 June 2012, and also a narrative description of the transit viewing from Tromsoe, Vardoe and Alta. The title of the book, Meeting Venus, refers the title of a play by the Hungarian film director, screenwriter and opera director Istvan Szabo (1938-). The autobiographical movie Meeting Venus (1991) directed by him is based on his experience directing Tannhauser at the Paris Opera in 1984. The movie brings the story of an imaginary international opera company that encounters a never ending series of difficulties and pitfalls that symbolise the challenges of any multicultural and international endeavour. As is evident from the many papers presented in this book, Meeting Venus not only contains the epic tales of the transits of the seventeenth, eighteenth and nineteenth centuries, it also covers the conference

  9. Impact on air quality of measures to reduce CO2 emissions from road traffic in Basel, Rotterdam, Xi'an and Suzhou

    Science.gov (United States)

    Keuken, M. P.; Jonkers, S.; Verhagen, H. L. M.; Perez, L.; Trüeb, S.; Okkerse, W.-J.; Liu, J.; Pan, X. C.; Zheng, L.; Wang, H.; Xu, R.; Sabel, C. E.

    2014-12-01

    Two traffic scenarios to reduce CO2 emissions from road traffic in two European cities (Basel and Rotterdam) and two Chinese cities (Xi'an and Suzhou) were evaluated in terms of their impact on air quality. The two scenarios, one modelling a reduction of private vehicle kilometres driven by 10% on urban streets and the other modelling the introduction of 50% electric-powered private vehicle kilometres on urban streets, were both compared to a scenario following “business-as-usual”: 2020-BAU. The annual average concentrations of NO2, PM2.5, PM10 and elemental carbon (EC) were modelled separately in busy street canyons, near urban motorways and in the remainder of the urban area. It was concluded that traffic-related CO2 emissions in 2020-BAU could be expected to remain at the levels of 2010 in Basel and Rotterdam, while in Xi'an and Suzhou to increase 30-50% due to growth in the traffic volume. Traffic-related CO2 emissions may be reduced by up to 5% and 25%, respectively using the first and second scenarios. Air pollution in the Chinese cities is a factor 3 to 5 higher than in the European cities in 2010 and 2020-BAU. The impact of both CO2 reduction scenarios on air quality in 2020-BAU is limited. In Europe, due to implementation of stringent emission standards in all sectors, air quality is expected to improve at both the urban background and near busy road traffic. In China, the regional background is expected to improve for EC, stabilize for PM2.5 and PM10, and decrease for NO2. The urban background follows this regional trend, while near busy road traffic, air pollution will remain elevated due to the considerable growth in traffic volume. A major constraint for modelling air quality in China is access to the input data required and lack of measurements at ground level for validation.

  10. Public meetings

    CERN Multimedia

    Staff Association

    2013-01-01

    MARS SURVEY 5YR 2015 GENERAL INFORMATION ELECTIONS 2013   COME AND BE INFORMED! Public meetings Tuesday 1st Oct. 10 am Amphi IT, 31-3-004 Meyrin Tuesday 1st Oct. 2 pm Council Chamber, 503-1-001 Meyrin Friday 4 Oct. 10 am Amphi BE, 864-1-D02 Prévessin Monday 7 Oct. 2 pm Council Chamber, 503-1-001 (in English) Meyrin Tuesday 8 Oct. 10 am Amphi Kjell Johnsen, 30-7-018 Meyrin   Overview of the topics to be discussed Recognition of Merit – MARS Outcome of last exercise 2007 to 2013: lessons learned Survey: five-yearly review, give us your opinion General information CVI 2014 Voluntary programmes (PRP, SLS) Elections 2013 Renewal of the Staff Council 2014 - 2015  

  11. Public meeting

    CERN Multimedia

    Staff Association

    2015-01-01

    Last Monday at 9 a.m. the Council Chamber was full, with several people standing, for the public meeting of the Staff Association. Simultaneously, many of our colleagues followed the presentations in the Amphitheatre in Prévessin. We would like to thank all of you for the interest you have shown and for your feedback. In the introduction we explained how the Staff Association represents the staff in its discussions with Management and Member States, and how the staff itself defined, by its participation in the 2013 staff survey, the priority assigned to various points related to the employment conditions. The position of the Staff Association regarding the new contract policy, to be implemented as of 31 March 2015 after approval by Council, was stated. Then, in the framework of the 2015 five-yearly review, the general approach that we would like to see for the new career structure, was explained. Concerning diversity, based on what we know about the situation in other international organiza...

  12. Fruitful meeting

    CERN Document Server

    Mike Lamont

    2010-01-01

    The annual meeting for the LHC Performance Workshop was held in Chamonix from 25 to 29 January 2010 in the Centre de Congrès Le Majestic. The Workshop focused on how to reach the maximum operating energy.   The LHC Performance Workshop took place between 25 and 29 January 2010 in a rather chilly Chamonix. Following the successful start of beam commissioning last year, there remain a number of important questions about the near future of the machine. Topics discussed included the maximum operational energy that will be possible in 2010 and the steps need to go above the planned 2010 start-up energy of 3.5 TeV. Of particular importance were the required splice and magnet consolidation measures that would be demanded by an increase above this energy.  The energy in the magnets and beams will always represent a considerable threat, and the possible impact of an incident and the potential measures required to speed up a recovery were put on the table. Safety is critical and there were...

  13. Joint USDA/DOE meeting

    Energy Technology Data Exchange (ETDEWEB)

    1994-07-01

    This documents contains the details from the USDA/USDOE meeting on April 11--12, 1994. Topics discussed include: genetic research, environmental research, renewable energy sources, food supply, improved fertilizers, new pesticides, research programs combining the efforts of the two agencies to develop new products for use in the agriculture industry, environmentally safe products, getting more with less money, and various other subjects dealing with how cooperation among these agencies can improve the agriculture industry.

  14. 75 FR 66061 - Meetings

    Science.gov (United States)

    2010-10-27

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  15. 76 FR 37062 - Meetings

    Science.gov (United States)

    2011-06-24

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  16. 78 FR 12715 - Meetings

    Science.gov (United States)

    2013-02-25

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  17. 76 FR 68127 - Meetings

    Science.gov (United States)

    2011-11-03

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular Board meeting in Washington, DC, Wednesday, November...

  18. 77 FR 7126 - Meetings

    Science.gov (United States)

    2012-02-10

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  19. 77 FR 36479 - Meetings

    Science.gov (United States)

    2012-06-19

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  20. 76 FR 21702 - Meetings

    Science.gov (United States)

    2011-04-18

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  1. 75 FR 13075 - Meetings

    Science.gov (United States)

    2010-03-18

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  2. 77 FR 74827 - Meetings

    Science.gov (United States)

    2012-12-18

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  3. 76 FR 78611 - Meetings

    Science.gov (United States)

    2011-12-19

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  4. 75 FR 80455 - Meetings

    Science.gov (United States)

    2010-12-22

    ... rules that are applicable to the public. Notices of hearings #0;and investigations, committee meetings...; ] ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and...

  5. 75 FR 22100 - Meetings

    Science.gov (United States)

    2010-04-27

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. ] SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  6. 77 FR 51513 - Meetings

    Science.gov (United States)

    2012-08-24

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  7. 76 FR 10557 - Meetings

    Science.gov (United States)

    2011-02-25

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular committee and Board meetings in Washington, DC,...

  8. 78 FR 76101 - Meetings

    Science.gov (United States)

    2013-12-16

    ... regarding the meetings, please contact David Capozzi, Executive Director, (202) 272- 0010 (voice); (202) 272...; Information and Communications Technologies; Classroom Acoustics; Emergency Transportable Housing; Passenger... sign language interpreters will be available at the Board meeting and committee meetings....

  9. On the unification of international transport law from the Rotterdam Rules%从《鹿特丹规则》看国际货物运输法律的统一

    Institute of Scientific and Technical Information of China (English)

    张永坚

    2012-01-01

    Based on the summary of the evaluations on the Rotterdam Rules, this paper reveals the gap between the effect and the target of the Rotterdam Rules, and points out that the existing problems will limit the Convention, influence its goal of unity. It also recommends that the international community needs continue to explore a way to unify the legal system of international transport of goods. Meanwhile, it is suggested that it is not the right time for China to consider signing and joining the Rotterdam Rules at present.%在总结对《鹿特丹规则》不同评价的基础上,揭示《鹿特丹规则》效果和目标存在的偏差,提出该公约存在的问题将限制其作用,影响其统一化的目标。建议国际社会继续探讨国际货物运输法律制度的统一途径,并建议中国暂时不考虑签署和加入《鹿特丹规则》。

  10. Genetic Discrimination

    Science.gov (United States)

    ... in Genetics Archive Regulation of Genetic Tests Genetic Discrimination Overview Many Americans fear that participating in research ... I) and employment (Title II). Read more Genetic Discrimination and Other Laws Genetic Discrimination and Other Laws ...

  11. 75 FR 1780 - Meetings

    Science.gov (United States)

    2010-01-13

    ... CORPORATION Meetings AGENCY: Farm Credit System Insurance Corporation Board; Regular Meeting. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). DATE AND TIME: The meeting of the Board will be held at the offices of the Farm Credit...

  12. Development of a Food Group-Based Diet Score and Its Association with Bone Mineral Density in the Elderly: The Rotterdam Study

    Science.gov (United States)

    de Jonge, Ester A. L.; Kiefte-de Jong, Jessica C.; de Groot, Lisette C. P. G. M.; Voortman, Trudy; Schoufour, Josje D.; Zillikens, M. Carola; Hofman, Albert; Uitterlinden, André G.; Franco, Oscar H.; Rivadeneira, Fernando

    2015-01-01

    No diet score exists that summarizes the features of a diet that is optimal for bone mineral density (BMD) in the elderly. Our aims were (a) to develop a BMD-Diet Score reflecting a diet that may be beneficial for BMD based on the existing literature, and (b) to examine the association of the BMD-Diet Score and the Healthy Diet Indicator, a score based on guidelines of the World Health Organization, with BMD in Dutch elderly participating in a prospective cohort study, the Rotterdam Study (n = 5144). Baseline dietary intake, assessed using a food frequency questionnaire, was categorized into food groups. Food groups that were consistently associated with BMD in the literature were included in the BMD-Diet Score. BMD was measured repeatedly and was assessed using dual energy X-ray absorptiometry. The BMD-Diet Score considered intake of vegetables, fruits, fish, whole grains, legumes/beans and dairy products as “high-BMD” components and meat and confectionary as “low-BMD” components. After adjustment, the BMD-Diet Score was positively associated with BMD (β (95% confidence interval) = 0.009 (0.005, 0.012) g/cm2 per standard deviation). This effect size was approximately three times as large as has been observed for the Healthy Diet Indicator. The food groups included in our BMD-Diet Score could be considered in the development of future dietary guidelines for healthy ageing. PMID:26295256

  13. Development of a Food Group-Based Diet Score and Its Association with Bone Mineral Density in the Elderly: The Rotterdam Study

    Directory of Open Access Journals (Sweden)

    Ester A.L. de Jonge

    2015-08-01

    Full Text Available No diet score exists that summarizes the features of a diet that is optimal for bone mineral density (BMD in the elderly. Our aims were (a to develop a BMD-Diet Score reflecting a diet that may be beneficial for BMD based on the existing literature, and (b to examine the association of the BMD-Diet Score and the Healthy Diet Indicator, a score based on guidelines of the World Health Organization, with BMD in Dutch elderly participating in a prospective cohort study, the Rotterdam Study (n = 5144. Baseline dietary intake, assessed using a food frequency questionnaire, was categorized into food groups. Food groups that were consistently associated with BMD in the literature were included in the BMD-Diet Score. BMD was measured repeatedly and was assessed using dual energy X-ray absorptiometry. The BMD-Diet Score considered intake of vegetables, fruits, fish, whole grains, legumes/beans and dairy products as “high-BMD” components and meat and confectionary as “low-BMD” components. After adjustment, the BMD-Diet Score was positively associated with BMD (β (95% confidence interval = 0.009 (0.005, 0.012 g/cm2 per standard deviation. This effect size was approximately three times as large as has been observed for the Healthy Diet Indicator. The food groups included in our BMD-Diet Score could be considered in the development of future dietary guidelines for healthy ageing.

  14. New Genetics

    Science.gov (United States)

    ... Home > Science Education > The New Genetics The New Genetics Living Laboratories Classroom Poster Order a Free Copy ... Piece to a Century-Old Evolutionary Puzzle Computing Genetics Model Organisms RNA Interference The New Genetics is ...

  15. 77 FR 511 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-01-05

    ... of Committee: Genes, Genomes, and Genetics Integrated Review Group, Molecular Genetics B Study... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings... Urological Systems Integrated Review Group, Clinical, Integrative and Molecular Gastroenterology Study...

  16. 管理大型盛事策略:以鹿特丹为例%Managing Mega Event Strategy: the Case of Rotterdam

    Institute of Scientific and Technical Information of China (English)

    陈雅薇

    2011-01-01

    利用大型盛事提高城市竞争力和在国际舞台的地位逐渐成为荷兰众多城市在后工业时代的重要策略.然而,大型盛事策略的实践以及这些大型盛事在多大程度上对主办城市的城市更新起到促进作用只是在近年来成为争论的一个主题.这篇文章引用鹿特丹为例研究了荷兰城市如何利用大型盛事策略进行形象重塑和城市转型,以及策划大型盛事的动机、管理策略和迄今为止的影响.%Using mega event to increase competitiveness and position cities on the world stage has been an important strategy for many Dutch cities in the post industrial era. However,how mega event works in the practice and to what extent these mega events stimulate urban transformation process of the host cities have only become a topic in debate in recent years. This paper uses Rotterdam as an example to examine how Dutch cities explored mega event strategy for their re-imaging process and urban transformation process as well as the motives behind hosting mega events, the following management strategies and the impacts so far.

  17. Creating patient value in glaucoma care: applying quality costing and care delivery value chain approaches--a five-year case study in the Rotterdam Eye Hospital.

    Science.gov (United States)

    de Korne, Dirk F; Sol, Kees; Custers, Thomas; van Sprundel, Esther; van Ineveld, B Martin; Lemij, Hans G; Klazinga, Niek S

    2009-01-01

    The purpose of this paper is to explore in a specific hospital care process the applicability in practice of the theories of quality costing and value chains. In a retrospective case study an in-depth evaluation of the use of a quality cost model (QCM) and the applicability of Porter's care delivery value chain (CDVC) was performed in a specific care process: glaucoma care over the period 2001 to 2006 in the Rotterdam Eye Hospital in The Netherlands. The case study shows a reduction of costs per product by increasing the number of outpatient visits and surgery combined with a higher patient satisfaction. Reduction of costs of non-compliance by using the QCM is small, due to the absence of (external) financial incentives for both the hospital and individual physicians. For CDVC to be supportive to an integrated quality and cost management the notion "patient value" needs far more specification as mutually agreed on by the stakeholders involved and related reimbursement needs to depend on realised outcomes. The case study just focused on one specific care process in one hospital. To determine effects in other areas of health care, it is important to study the use and applicability of the QCM and the CDVC in other care processes and settings. QCM and a CDVC can be useful tools for hospital management to manage the outcomes on both quality and costs, but impact is dependent on the incentives in the context of the existing organisational and reimbursement system and asks for an agreed on operationalisation among the various stakeholders of the notion of patient value.

  18. 75 FR 39205 - Meetings

    Science.gov (United States)

    2010-07-08

    ... is as follows: Wednesday, July 28, 2010 9:45-10:30 a.m. Ad Hoc Committee on Classroom Acoustics. 10... Director, (202) 272- 0010 (voice) and (202) 272-0082 (TTY). SUPPLEMENTARY INFORMATION: At the Board meeting... sign language interpreters will be available at the Board meetings and information meeting....

  19. Making Meetings Work Better.

    Science.gov (United States)

    Standke, Linda

    1978-01-01

    Focusing on the increased use by trainers of off-site facilities for employee training meetings, this article looks at some improvements and the expanding market in the meeting site industry. It also highlights emerging trends in the industry and covers the growth of meeting planning into a profession. (EM)

  20. 78 FR 38009 - Meetings

    Science.gov (United States)

    2013-06-25

    ...--Hearing on Passenger Vessels Proposed Rule 1:30-3:30 p.m.--Board Meeting ADDRESSES: Meetings will be held... INFORMATION CONTACT: For further information regarding the meetings, please contact David Capozzi, Executive....access-board.gov/about/policies/fragrance.htm for more information). David M. Capozzi, Executive...

  1. Determinism and Underdetermination in Genetics: Implications for Students' Engagement in Argumentation and Epistemic Practices

    Science.gov (United States)

    Jiménez-Aleixandre, María Pilar

    2012-11-01

    In the last two decades science studies and science education research have shifted from an interest in products (of science or of learning), to an interest in processes and practices. The focus of this paper is on students' engagement in epistemic practices (Kelly in Teaching scientific inquiry: Recommendations for research and implementation. Sense Publishers, Rotterdam, pp 99-117, 2008), or on their practical epistemologies (Wickman in Sci Educ 88(3):325-344, 2004). In order to support these practices in genetics classrooms we need to take into account domain-specific features of the epistemology of genetics, in particular issues about determinism and underdetermination. I suggest that certain difficulties may be related to the specific nature of causality in genetics, and in particular to the correspondence between a given set of factors and a range of potential effects, rather than a single one. The paper seeks to bring together recent developments in the epistemology of biology and of genetics, on the one hand, with science education approaches about epistemic practices, on the other. The implications of these perspectives for current challenges in learning genetics are examined, focusing on students' engagement in epistemic practices, as argumentation, understood as using evidence to evaluate knowledge claims. Engaging in argumentation in genetics classrooms is intertwined with practices such as using genetics models to build explanations, or framing genetics issues in their social context. These challenges are illustrated with studies making part of our research program in the USC.

  2. Meetings in Organizations

    DEFF Research Database (Denmark)

    Ravn, Ib

    Meetings in organizations have evolved from the infrequent, slightly authoritarian meeting of the 1950?s to today?s ubiquitous and often longwinded, every-body-has-a-right-to-speak meeting. But two important, recent trends in work and business pose new challenges. Today, organizational work is seen...... showed that although employees were satisfied with their managers; traditional meeting-management skills, the customer was largely invisible in organizational meetings, and the hearts and minds of the employees were not engaged to any significant degree in meetings. It is concluded that despite massive...... changes in business and work life, the meeting has changed little. It has been poorly integrated into the organizational value chain and is rarely experienced as very important to either customers or employees....

  3. Genetic algorithms

    Science.gov (United States)

    Wang, Lui; Bayer, Steven E.

    1991-01-01

    Genetic algorithms are mathematical, highly parallel, adaptive search procedures (i.e., problem solving methods) based loosely on the processes of natural genetics and Darwinian survival of the fittest. Basic genetic algorithms concepts are introduced, genetic algorithm applications are introduced, and results are presented from a project to develop a software tool that will enable the widespread use of genetic algorithm technology.

  4. Genetic Mapping

    Science.gov (United States)

    ... Fact Sheets Fact Sheets En Español: Mapeo Genético Genetic Mapping What is genetic mapping? How do researchers create ... genetic map? What are genetic markers? What is genetic mapping? Among the main goals of the Human Genome ...

  5. Considerations from More Points of View on Identification of the Carrier under the Rotterdam Rules%对《鹿特丹规则》关于承运人识别问题的多角度思考

    Institute of Scientific and Technical Information of China (English)

    郭春风

    2011-01-01

    本文结合国际航运及贸易实务,从法律和实践的多重角度,对《鹿特丹规则》关于承运人识别的法律推定进行研究和思考。《鹿特丹规则》关于承运人识别的法律推定,对船东可能带来严重不公平,中国政府和中国船东等应当充分注意其利弊并采取对策。%Connected with the business of international shipping and trade,from more points of view of legal and practice,this article makes some study and considerations on identification of the carrier under the Rotterdam Rules.The presumptions about identification of the carrier under the Rotterdam Rules are very unfair to ship-owners.The government of China and the ship-owner of China should show great concern to its advantages and disadvantages,and should take some countermeasure.

  6. Desorption behaviour of polycyclic aromatic hydrocarbons after long-term storage of two harbour sludges from the port of Rotterdam, The Netherlands

    KAUST Repository

    Heister, Katja

    2013-04-12

    Purpose: The desorption behaviour of 16 polycyclic aromatic hydrocarbons (PAHs) in sludges from two sites of the port of Rotterdam, The Netherlands, which are designated to be stored in a subaqueous sludge depository, was investigated after a storage time of 14 years at 4 °C under anaerobic conditions in the dark, mimicking depository conditions. Such long-term storage is believed to effect the desorption of the PAHs. Materials and methods: Batch desorption experiments over a time period of 130 days were performed with the brackish Beerkanaal (BK) sludge and the freshwater Beneden Merwede River (BMR) sludge. The organic carbon-water partitioning coefficient (K OC) values were calculated and compared to values of a previous study on the same sludges after a storage time of 3 years and to values obtained from calculations based on octanol-water partitioning coefficient (K OW) values. Additionally, the organic matter of the sludges was characterised by C and N elemental analysis and solid-state 13C nuclear magnetic resonance spectroscopy. Results and discussion: Only desorption of low molecular weight PAHs up to pyrene was detected. Several K OC values were higher compared to the values from the previous study, and all were increased compared to values based on K OW values. It is assumed that the increase in K OC was an effect of the prolonged contact time, causing slow intradomain diffusion of PAHs into the condensed carbon domains. Desorption was higher in BK than in BMR, which is explained by differences in organic matter composition because BMR (containing predominantly aromatic carbon) and BK (which was dominated by lipids) contained the same amount of organic carbon. It is inferred that lipids compete with PAHs for sorption sites on the aromatic carbon, so that lipids block these sorption sites, and the PAHs are adsorbed to the lipids. Conclusions: Since the amounts of PAHs desorbed from both sludges in this study were so low, it is supposed that long

  7. Report of a Vegetables Network : Second Meeting, 26–28 June 2007, Olomouc, Czech Republic

    NARCIS (Netherlands)

    Astley, D.; Bas, N.; Branca, F.; Daunay, M.C.; Keller, J.; Dooijeweert, van W.; Treuren, van R.; Maggioni, L.; Lipman, E.

    2009-01-01

    The Second Meeting of the Vegetables Network (VEGNET) of the European Cooperative Programme for Plant Genetic Resources (ECPGR) was held on 26-28 June 2007 in Olomouc, Czech Republic. The meeting was organized jointly with the Third Meeting of the ECPGR Working Group on Medicinal and Aromatic Plants

  8. Taking minutes of meetings

    CERN Document Server

    Gutmann, Joanna

    2016-01-01

    aking Minutes of Meetings guides you through the entire process behind minute taking: arranging the meeting; writing the agenda; creating the optimum environment; structuring the meeting and writing notes up accurately. The minute-taker is one of the most important and powerful people in a meeting and you can use this opportunity to develop your knowledge, broaden your horizons and build credibility within the organization. Taking Minutes of Meetings is an easy to read 'dip-in, dip-out' guide which shows you how to confidently arrange meetings and produce minutes. It provides hands-on advice about the sections of a meeting as well as tips on how to create an agenda, personal preparation, best practice advice on taking notes and how to improve your accuracy. Brand new chapters of this 4th edition include guidance on using technology to maximize effectiveness and practical help with taking minutes for a variety of different types of meetings. The creating success series of books... With over one million copi...

  9. CLAFA Council Meeting Held

    Institute of Scientific and Technical Information of China (English)

    JiWei

    2004-01-01

    The Council Meeting of the China-Latin America Friendship Association (CLAFA) was held in Beijing on February 3, 2004. More than 30 council members attended the meeting. It was presided over by CLAFA Vice President Li Xiaolin. Cheng Siwei, CLAFA president and vice chairman of

  10. CMS MANAGEMENT MEETINGS

    CERN Multimedia

    2010-01-01

    The Agendas and Minutes of the Management Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 The Agendas and Minutes of the Collaboration Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174

  11. Evaluating meeting behavior

    NARCIS (Netherlands)

    Post, W.M.; Boogaard, S.A.A. van den

    2005-01-01

    Many attempts are underway for developing meeting support tools, but less attention is paid to the evaluation of meetingware. This paper describes the development of an instrument for evaluating meeting behavior. An explorative research is done using a rating scale, questionnaires and information fl

  12. CMS MANAGEMENT MEETINGS

    CERN Multimedia

    2011-01-01

    The Agendas and Minutes of the Management Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 The Agendas and Minutes of the Collaboration Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174

  13. CMS MANAGEMENT MEETINGS

    CERN Multimedia

    2011-01-01

    The Agendas and Minutes of the Management Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 The Agendas and Minutes of the Collaboration Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174  

  14. CMS MANAGEMENT MEETINGS

    CERN Multimedia

    2012-01-01

      The Agendas and Minutes of the Management Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 The Agendas and Minutes of the Collaboration Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174

  15. Linking pre-meeting communication to meeting effectiveness

    NARCIS (Netherlands)

    Allen, J.A.; Lehmann-Willenbrock, N.K.; Landowski, N.

    2014-01-01

    Purpose – The present study investigates the importance of communication that occurs just before workplace meetings (i.e., pre-meeting talk). We explore how pre-meeting talk impacts meeting effectiveness through the” ripple effect”, allowing before meeting communication/behaviors to ripple into and

  16. Annual General Meeting

    CERN Multimedia

    Staff Association

    2014-01-01

      STAFF ASSOCIATION Our next annual general meeting will take place on : Thursday 22 May 2014 at 11:00 AM Building 40-S2-D01 For further information visit our website : https://indico.cern.ch/event/313124/

  17. ASIST 2002 annual meeting

    CERN Multimedia

    Peek, R

    2003-01-01

    Review of discussions and presentations at the American Society for Information Science and Technology 2002 annual meeting. Topics covered included new models of scholarly publishing and the development of the semantic web (1 page).

  18. Meeting of the Multinationals

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ The World Economic Forum's Annual Meeting of the New Champions 2010, or the "Summer Davos," was held in north China's Tianjin Municipality from September 13-15 under the theme "Driving Growth Through Sustainability."

  19. CMS Collaboration Board Meeting

    CERN Multimedia

    Hoch, Michael

    2013-01-01

    The first CMS Collaboration Board meeting of the year (2013) provided an opportunity to thank Teresa Rodrigo, Matthias Kasemann and Randy Ruchti, the 2011-12 CB Chair, Deputy Chair and Secretary, respectively.

  20. Genetic Disorders

    Science.gov (United States)

    ... This can cause a medical condition called a genetic disorder. You can inherit a gene mutation from ... during your lifetime. There are three types of genetic disorders: Single-gene disorders, where a mutation affects ...

  1. Genetic modification and genetic determinism.

    Science.gov (United States)

    Resnik, David B; Vorhaus, Daniel B

    2006-06-26

    In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions.

  2. 浅析《鹿特丹规则》对海上运输关系的影响%Analysis on the Influence of "Rotterdam Rules" on Maritime Transport Relationship

    Institute of Scientific and Technical Information of China (English)

    邹红兵

    2011-01-01

    The United Nations passed Rotterdam Rules in December 2008, the main purpose of the rules is to replace the existing international conventions, to realize the goods transport rules of international unity. New rules balance the interests of the relevant shipping, on the basis of the existing international maritime transport of goods, expand maritime law of body , look for best interests of resistance of carrier and shipper, regulate the marine rights and obligations . The article will start from the legislative system of Rotterdam rules, discuss legal relation of the new rule and the influence on the relevant shipping interests of the rights and obligations.%2008年12月联合国通过了《鹿特丹规则》,该规则制定的主要目的是取代现有的国际海货物运输公约,以实现货物运输规则的国际统一.新规则是航运利益各相关方平衡器,在原有《国际海上货物运输法》的基础上,扩大了海商法调整的主体,寻求承运人与托运人最大利益平衡点,规范了海运利益各项相关方权利与义务.文中将从《鹿特丹规则》立法体系出发,讨论新规则所调整的各种法律关系以及对海运利益相关方权利义务的影响.

  3. Imaging Genetics

    Science.gov (United States)

    Munoz, Karen E.; Hyde, Luke W.; Hariri, Ahmad R.

    2009-01-01

    Imaging genetics is an experimental strategy that integrates molecular genetics and neuroimaging technology to examine biological mechanisms that mediate differences in behavior and the risks for psychiatric disorder. The basic principles in imaging genetics and the development of the field are discussed.

  4. Genetic principles.

    Science.gov (United States)

    Abuelo, D

    1987-01-01

    The author discusses the basic principles of genetics, including the classification of genetic disorders and a consideration of the rules and mechanisms of inheritance. The most common pitfalls in clinical genetic diagnosis are described, with emphasis on the problem of the negative or misleading family history.

  5. Imaging Genetics

    Science.gov (United States)

    Munoz, Karen E.; Hyde, Luke W.; Hariri, Ahmad R.

    2009-01-01

    Imaging genetics is an experimental strategy that integrates molecular genetics and neuroimaging technology to examine biological mechanisms that mediate differences in behavior and the risks for psychiatric disorder. The basic principles in imaging genetics and the development of the field are discussed.

  6. 76 FR 57068 - Board Meeting; Sunshine Act Meetings

    Science.gov (United States)

    2011-09-15

    ... Board Meeting; Sunshine Act Meetings TIME AND DATE: September 26, 2011, 9 a.m.-1:30 p.m. PLACE: 901 N...: Approval of the Minutes of the June 6, 2011, Meeting of the Board of Directors Strategic Planning President and Management Report Communications Strategy Advisory Council Next Meetings PORTIONS TO BE OPEN...

  7. 77 FR 59979 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2012-10-01

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a closed meeting of the Advisory...

  8. 77 FR 71828 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2012-12-04

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a meeting of the Advisory Committee...

  9. 75 FR 28062 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2010-05-19

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a meeting of the Advisory Committee...

  10. 76 FR 17967 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2011-03-31

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a closed meeting of the Advisory...

  11. 75 FR 16510 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2010-04-01

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a closed meeting of the Advisory...

  12. 75 FR 76486 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2010-12-08

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a meeting of the Advisory Committee...

  13. 78 FR 19008 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2013-03-28

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a closed meeting of the Advisory...

  14. 78 FR 36575 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2013-06-18

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a meeting of the Advisory Committee...

  15. 75 FR 59292 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2010-09-27

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a closed meeting of the Advisory...

  16. 77 FR 34408 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2012-06-11

    ... ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of a meeting of the Advisory Committee...

  17. Genetic modification and genetic determinism

    OpenAIRE

    Vorhaus Daniel B; Resnik David B

    2006-01-01

    Abstract In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound....

  18. Hydrogen Contractors Meeting

    Energy Technology Data Exchange (ETDEWEB)

    Fitzsimmons, Tim [Dept. of Energy (DOE), Washington DC (United States). Office of Basic Energy Sciences. Division of Materials Sciences and Engineering

    2006-05-16

    This volume highlights the scientific content of the 2006 Hydrogen Contractors Meeting sponsored by the Division of Materials Sciences and Engineering (DMS&E) on behalf of the Office of Basic Energy Sciences (BES) of the U. S. Department of Energy (DOE). Hydrogen Contractors Meeting held from May 16-19, 2006 at the Crystal Gateway Marriott Hotel Arlington, Virginia. This meeting is the second in a series of research theme-based Contractors Meetings sponsored by DMS&E held in conjunction with our counterparts in the Office of Energy Efficiency and Renewable Energy (EERE) and the first with the Hydrogen, Fuel Cells and Infrastructure Technologies Program. The focus of this year’s meeting is BES funded fundamental research underpinning advancement of hydrogen storage. The major goals of these research efforts are the development of a fundamental scientific base in terms of new concepts, theories and computational tools; new characterization capabilities; and new materials that could be used or mimicked in advancing capabilities for hydrogen storage.

  19. The Short, Productive Board Meeting

    Science.gov (United States)

    McAdams, Donald R.

    2005-01-01

    Board meetings are the time and place where school boards act. In fact, only when coming together as a body in a legal meeting do school board members become a board. Effective board meetings are the first prerequisite for an effective board. Furthermore, what parents and voters see at board meetings determines largely what they think about their…

  20. 15. ESRF users meeting

    Energy Technology Data Exchange (ETDEWEB)

    Fotis C, Kafatos; Ulrich, K.U.; Weib, S.; Rossberg, A.; Scheinost, A.C.; Foerstendorf, H.; Zanker, H.; Meyerheim, H.L.; Sander, D.; Popescu, R.; Kirschner, J.; Robach, O.; Ferrer, S.; Lyman, P.F.; Shneerson, V.L.; Fung, R.; Harder, R.J.; Parihar, S.S.; Johnson-Steigelman, H.T.; Lu, E.D.; Saldin, D.K.; Eastwood, D.S.; Atkinson, D.; Tanner, B.K.; Hase, T.P.A.; Van Kampen, M.; Hjorvarsson, B.; Brown, S.; Thompson, P.; Konovalov, O.; Saint-Martin, E.; Daillant, J.; Luzet, D.; Szlachetko, J.; Barrett, R.; Berset, M.; Dousse, J.C.; Fennane, K.; Hoszowska, J.; Kubala-Kukus, A.; Pajek, M.; Szlachetko, M.; Monaco, A.; Chumakov, A.; Crichton, W.; Van Buerck, I.; Wortmann, G.; Meyer, A.; Ponkratz, U.; Ruffer, R.; Sakurai, Y.; Hiraoka, N.; Itou, M.; Buslaps, T.; Honkimki, V.; Maeno, Y.; Collart, E.; Shukla, A.; Rueff, J.P.; Leininger, Ph.; Ishii, H.; Cai, Y.; Cheong, S.W.; Martins, R.M.S.; Schell, N.; Beckers, M.; Silva, R.; Braz Fernandes, F.M.; Acapito, F.; Seta, M. de; Capelini, G.; Giorgi, M.; Schorr, G.; Geandier, G.; Alves Marques, M.; Barros Marquesa, M.I. de; Cabaco, M.I.; Gaspara, A.M.; Marques, M.P.M.; Amado, A.M.; Amorim da Costa, A.M.; Bruneseaux, F.; Weisbecker, P.; Brandao, M.J.; Aeby-Gautier, E.; Simmonds, H.; Lei, C.; Das, A.; Trolley, D.; Thomas, H.E.; Macdonald, J.E.; Wiegart, L.; Tolan, M.; Struth, B.; Petukhov, A.V.; Thijssen, J.H.J.; Hart, D.C.; Imhof, A.; Van Blaaderen, A.; Dolbnya, I.P.; Snigirev, A.; Mossaid, A.; Snigireva, I.; Reconditi, M.; Brunello, E

    2005-07-01

    This document gathers the posters presented on the one day and a half long plenary meeting workshop. This meeting workshop is a privileged forum where ESRF users can exchange their views on the latest scientific and technical development involving synchrotron radiation. One poster deals with the investigation of colloid composition and uranium bond structure to see whether the migration of contaminants from abandoned mines could be stimulated or attenuated by colloids. Another poster is dedicated to the investigation of the uranium speciation in covered mine tailings by a combination of micro-spectroscopic and wet chemical approaches. 2 posters deal with the contribution of synchrotron radiation to radiotherapy.

  1. MEETING OF THE MINDS?

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    For the first time since regular meetings of the leaders of the world's richest countries were initiated in 1975, Russia, which formally joined the "club" in 1997, assumed the rotating chairmanship of the group this year. July 15-17, the leaders of the Group of Eight (G-8) leading industrial nations met in St.Petersburg, Russia, the old imperial capital, for their annual summit.This marked the first time that Russia has hosted a G-8 meeting,enabling it to set the agenda and highlight its own interests an...

  2. Counseling customers: emerging roles for genetic counselors in the direct-to-consumer genetic testing market.

    Science.gov (United States)

    Harris, Anna; Kelly, Susan E; Wyatt, Sally

    2013-04-01

    Individuals now have access to an increasing number of internet resources offering personal genomics services. As the direct-to-consumer genetic testing (DTC GT) industry expands, critics have called for pre- and post-test genetic counseling to be included with the product. Several genetic testing companies offer genetic counseling. There has been no examination to date of this service provision, whether it meets critics' concerns and implications it may have for the genetic counseling profession. Considering the increasing relevance of genetics in healthcare, the complexity of genetic information provided by DTC GT, the mediating role of the internet in counseling, and potential conflicts of interest, this is a topic which deserves further attention. In this paper we offer a discourse analysis of ways in which genetic counseling is represented on DTC GT websites, blogs and other online material. This analysis identified four types of genetic counseling represented on the websites: the integrated counseling product; discretionary counseling; independent counseling; and product advice. Genetic counselors are represented as having the following roles: genetics educator; mediator; lifestyle advisor; risk interpreter; and entrepreneur. We conclude that genetic counseling as represented on DTC GT websites demonstrates shifting professional roles and forms of expertise in genetic counseling. Genetic counselors are also playing an important part in how the genetic testing market is taking shape. Our analysis offers important and timely insights into recent developments in the genetic counseling profession, which have relevance for practitioners, researchers and policy makers concerned with the evolving field of personal genomics.

  3. Genetic barcodes

    Energy Technology Data Exchange (ETDEWEB)

    Weier, Heinz -Ulrich G

    2015-08-04

    Herein are described multicolor FISH probe sets termed "genetic barcodes" targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes.

  4. Genetically modified foods and allergy.

    Science.gov (United States)

    Lee, T H; Ho, H K; Leung, T F

    2017-06-01

    2015 marked the 25th anniversary of the commercial use and availability of genetically modified crops. The area of planted biotech crops cultivated globally occupies a cumulative two billion hectares, equivalent to twice the land size of China or the United States. Foods derived from genetically modified plants are widely consumed in many countries and genetically modified soybean protein is extensively used in processed foods throughout the industrialised countries. Genetically modified food technology offers a possible solution to meet current and future challenges in food and medicine. Yet there is a strong undercurrent of anxiety that genetically modified foods are unsafe for human consumption, sometimes fuelled by criticisms based on little or no firm evidence. This has resulted in some countries turning away food destined for famine relief because of the perceived health risks of genetically modified foods. The major concerns include their possible allergenicity and toxicity despite the vigorous testing of genetically modified foods prior to marketing approval. It is imperative that scientists engage the public in a constructive evidence-based dialogue to address these concerns. At the same time, improved validated ways to test the safety of new foods should be developed. A post-launch strategy should be established routinely to allay concerns. Mandatory labelling of genetically modified ingredients should be adopted for the sake of transparency. Such ingredient listing and information facilitate tracing and recall if required.

  5. Reviving the Town Meeting.

    Science.gov (United States)

    Grove, Tim

    1996-01-01

    Discusses the use of the National Issues Forum's (NIF's) town meetings in efforts to increase citizen participation in democratic processes. Describes the Catholic adaptation of the NIF approach, providing examples of its use at the high school, college, and community level. (MAB)

  6. ASHRAE Summer Meeting 1998

    DEFF Research Database (Denmark)

    Rudbeck, Claus Christian

    1998-01-01

    ASHRAE's (American Society for Heating, Refrigerating and Air- Condition Engineering) summer meeting was visited in June in Toronto. ASHRAE is an American organization dealing with American problems in HVAC, but many results can be used under Danish conditions. It is therefore essential that Danish...

  7. 96TH ACCU MEETING

    CERN Document Server

    2012-01-01

    DRAFT Agenda for the meeting to be held on Friday 15 June 2012 at 9:15 a.m. in room 60-6-002   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. Matters arising       5. Experience with the Service Desk 6. Guidelines for private festivities on CERN sites 7. News from the CERN Management 8. Report on services from GS department 9. Reports from ACCU representatives on other Committees a. IT Service Review Meeting 10. Users’ Office news 11. Any Other Business 12. Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary)   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of ...

  8. 101TH ACCU MEETING

    CERN Document Server

    2013-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 11 September 2013 at 9.15 a.m. in Room 60-6-002   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. News from the CERN Management 5. Report on services from GS Department 6. Progress on health insurance for Users 7. Users’ Office News 8. Reports from ACCU representatives on other Committees      a. Scientific Information Policy Board (SIPB)      b. IT Service Review Meeting 9. Matters arising 10. Any Other Business 11. Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail. Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for t...

  9. Meeting diversity in ergonomics

    NARCIS (Netherlands)

    Pikaar, R.N.; Koningsveld, E.A.P.; Settels, P.J.M.

    2007-01-01

    Key Features: Offers the conceptual tools for creating more adaptable ergonomic designs to meet the needs of diverse human populations, Unlock the strategic business value found in ergonomically safe and comfortable products, Learn from in-depth case studies how ergonomic intervention was

  10. 109TH ACCU Meeting

    CERN Multimedia

    2015-01-01

    Agenda for the meeting to be held on Tuesday, 8 September 2015 at 9.15 a.m. in Room Georges Charpak (Room F, 60-6-015)   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting Report on services from GS department Report on services from IT department News from the CERN Management 60 years of the Staff Association The CERN Ombuds Opportunities to visit CERN Users’ Office News Matters arising Any other business ACCU Meetings 2016 (proposal) Agenda for the next meeting   Anyone wishing to raise any points under “Any other business” is invited to send them to the Chairperson in writing or by e-mail to ACCU.Secretary@cern.ch. Michael Hauschild (Secretary) ACCU is a forum for discussion between the CERN Management and representatives of the CERN users in order to review the practical means taken by CERN to support the work of Use...

  11. 94TH ACCU MEETING

    CERN Multimedia

    PH Department

    2011-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 7 December 2011 at 9:15 a.m. in room 60-6-002   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting Matters arising       News from the CERN Management Report on services from GS department Users’ Office news Report on new CHIS rules Creche status Report on Summer Students Users Organization in the U.S. (US LUO) Reports from ACCU representatives on other Committees Accommodation Facilities Working Group Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 13 is invited to send them to the Chairperson in writing or by e-mail to mailto:Michael.Hauschild@cern.ch subject = Next ACCU meeting.   Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review th...

  12. PREMIER MEETS THE PRESS

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    On March 14, Premier Wen Jiabao addressed the Chinese and foreign media at a press conference after the closing meeting of the Third Session of the 11th National People’s Congress. Edited highlights on a number of economic and social issues follow:

  13. PREMIER MEETS THE PRESS

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ March 14.Premier Wen Jiabao addressed the Chinese and foreign media at a press conference after the closing meeting of the Third Session of the 1 lth National People's Congress.Edited highlights on a number of economic and social issues follow:

  14. Meeting report: nuclear receptors

    DEFF Research Database (Denmark)

    Tuckermann, Jan; Bourguet, William; Mandrup, Susanne

    2010-01-01

    The biannual European Molecular Biology Organization (EMBO) conference on nuclear receptors was organized by Beatrice Desvergne and Laszlo Nagy and took place in Cavtat near Dubrovnik on the Adriatic coast of Croatia September 25-29, 2009. The meeting brought together researchers from all over...

  15. 113th ACCU Meeting

    CERN Multimedia

    2016-01-01

    Agenda for the meeting to be held on Tuesday, 6 September 2016​ at 9.15 a.m. in room Georges Charpak (Room F, 60-6-015).   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting News from the CERN Management Report on services from SMB Department Report on services from IT Department The International School Ferney-Voltaire / St. Genis The CERN Alumni Project Changes in rules to obtain dosimeters Changes of CHIS health insurance rules for MPAs Matters arising Any Other Business ACCU meetings 2017 Agenda for the next meeting   The Advisory Committee of CERN Users (ACCU) is a forum for discussion between the CERN Management and representatives of the CERN Users in order to review the practical means taken by CERN to support the work of Users of the Laboratory. The User Representatives to ACCU are: Austria M. Jeitler (manfred.jeitler@cern.ch) Belgium M. T...

  16. Genetic modification and genetic determinism

    Directory of Open Access Journals (Sweden)

    Vorhaus Daniel B

    2006-06-01

    Full Text Available Abstract In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions.

  17. 77 FR 60446 - Center for Scientific Review; Notice of Closed Meeting

    Science.gov (United States)

    2012-10-03

    ... Committee: Center for Scientific Review Special Emphasis Panel; Genomic, Molecular Genetics Variation... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meeting...

  18. 78 FR 11137 - Notice of Meeting of the National Organic Standards Board (NOSB)

    Science.gov (United States)

    2013-02-15

    ... of the implementation of the Organic Foods Production Act (7 U.S.C. 6501- 6522). The NOSB currently... the ad hoc Genetically Modified Organisms (GMO). The primary purpose of NOSB meetings is to provide...

  19. Highlights from the 7th European Meeting on Molecular Diagnostics

    NARCIS (Netherlands)

    Loonen, A.J.M.; Schuurman, R.; Brule, A.J.C. van den

    2012-01-01

    This report presents the highlights of the 7th European Meeting on Molecular Diagnostics held in Scheveningen, The Hague, The Netherlands, 12-14 October 2011. The areas covered included molecular diagnostics applications in medical microbiology, virology, pathology, hemato-oncology,clinical genetics

  20. Genetic Engineering

    Science.gov (United States)

    Phillips, John

    1973-01-01

    Presents a review of genetic engineering, in which the genotypes of plants and animals (including human genotypes) may be manipulated for the benefit of the human species. Discusses associated problems and solutions and provides an extensive bibliography of literature relating to genetic engineering. (JR)

  1. Genetic Counseling

    Science.gov (United States)

    ... for certain types of genetic conditions (such as Down syndrome) in the baby if mother-to-be is 35 years of age or more, or is concerned at any age about her chances of having a child with a genetic condition To learn about the ...

  2. Common genetic variation in the Estrogen Receptor Beta (ESR2 gene and osteoarthritis: results of a meta-analysis

    Directory of Open Access Journals (Sweden)

    Rivadeneira Fernando

    2010-11-01

    Full Text Available Abstract Background The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis. Methods In the discovery study, the Rotterdam Study-I, 7 single nucleotide polymorphisms (SNPs were genotyped and tested for association with hip (284 cases, 2772 controls, knee (665 cases, 2075 controls, and hand OA (874 cases, 2184 controls using an additive model. In the replication stage one SNP (rs1256031 was tested in an additional 2080 hip, 1318 knee and 557 hand OA cases and 4001, 2631 and 1699 controls respectively. Fixed- and random-effects meta-analyses were performed over the complete dataset including 2364 hip, 1983 knee and 1431 hand OA cases and approximately 6000 controls. Results The C allele of rs1256031 was associated with a 36% increased odds of hip OA in women of the Rotterdam Study-I (OR 1.36, 95% CI 1.08-1.70, p = 0.009. Haplotype analysis and analysis of knee- and hand OA did not give additional information. With the replication studies, the meta-analysis did not show a significant effect of this SNP on hip OA in the total population (OR 1.06, 95% CI 0.99-1.15, p = 0.10. Stratification according to gender did not change the results. In this study, we had 80% power to detect an odds ratio of at least 1.14 for hip OA (α = 0.05. Conclusion This study showed that common genetic variation in the ESR2 gene is not likely to influence the risk of osteoarthritis with effects smaller than a 13% increase.

  3. Genetic Romanticism

    DEFF Research Database (Denmark)

    Tupasela, Aaro

    2016-01-01

    . This article compares and contrasts the work of two doctors in Finland, Elias Lönnrot and Reijo Norio, working over a century and a half apart, to examine the ways in which they have contributed to the formation of national identity and unity. The notion of genetic romanticism is introduced as a term...... to complement the notion of national romanticism that has been used to describe the ways in which nineteenth-century scholars sought to create and deploy common traditions for national-romantic purposes. Unlike national romanticism, however, strategies of genetic romanticism rely on the study of genetic...... inheritance as a way to unify populations within politically and geographically bounded areas. Thus, new genetics have contributed to the development of genetic romanticisms, whereby populations (human, plant, and animal) can be delineated and mobilized through scientific and medical practices to represent...

  4. Summarizing craniofacial genetics and developmental biology (SCGDB).

    Science.gov (United States)

    Hall, Brian K

    2014-04-01

    This overview article highlights active areas of research in craniofacial genetics and developmental biology as reflected in presentations given at the 34th annual meeting of the Society of Craniofacial Genetics and Developmental Biology (SCGDB) in Montreal, Quebec on October 11, 2011. This 1-day meeting provided a stimulating occasion that demonstrated the present status of research in craniofacial genetics and developmental biology and where the field is heading. To accompany the abstracts published in this issue I have selected several themes that emerged from the meeting. After discussing the basis on which craniofacial defects/syndromes are classified and investigated, I address the multi-gene basis of craniofacial syndromes with an examination of the roles of Sox9 and FGF receptors in normal and abnormal craniofacial development. I then turn to the knowledge being gained from population-wide and longitudinal cohort studies and from the discovery of new signaling centers that regulate craniofacial development.

  5. Meetings in Academe: It's Time for an "EXTREME MEETING MAKEOVER!"

    Science.gov (United States)

    Berk, Ronald A.

    2012-01-01

    Meetings have a bad reputation with faculty. Rarely does one hear a positive word uttered about an upcoming or past meeting. That reputation has metastasized throughout higher education. The primary reason is because meetings can be major time wasters, accomplishing very little, often deteriorating into just another social event, or they may be…

  6. 77 FR 19034 - Meeting of the Advisory Committee; Meeting

    Science.gov (United States)

    2012-03-29

    ... No: 2012-7500] JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES Meeting of the Advisory Committee; Meeting AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Notice of Federal Advisory Committee meeting. SUMMARY: The Executive Director of the Joint Board for the Enrollment of Actuaries gives notice of...

  7. 95TH ACCU MEETING

    CERN Document Server

    2012-01-01

    Agenda for the meeting to be held on Wednesday 7 March 2012 at 9:15 a.m. in room 60-6-002   1.     Chairperson's remarks                            2.     Adoption of the agenda                               3.     Minutes of the previous meeting 4.     Matters arising        &am...

  8. 97TH ACCU MEETING

    CERN Multimedia

    2012-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 September 2012 at 9:15 a.m. in room 60-6-002      Chairperson's remarks                        Adoption of the agenda                               Minutes of the previous meeting New CERN Authentication and Authorization, and CERN Data Protection Policy Report on services from GS department               &am...

  9. ISKAF2010 Science Meeting

    Science.gov (United States)

    van Leeuwen, Joeri

    Radio astronomy - in its broadest sense from metre to sub-millimetre wavelengths - is making a major leap forward. Triggered by the efforts being made towards realising the Square Kilometre Array (SKA), a number of new facilities, or major upgrades of existing facilities, are coming on-line, bringing new excitement among radio astronomers and revitalising the interest of the astronomical community in general. The fantastic capabilities of these new facilities will revolutionise the way we do radio astronomy. The use of innovative technology solutions (including new software approaches and calibration algorithms) is expected to significantly enhance the performance of this new generation of radio telescopes. The associated advances in sensitivity, field-of-view, frequency range and spectral resolution guarantees that new and exciting science will be conducted. We are now truly entering a new golden age for radio astronomy. And this is only the beginning! The meeting takes its inspiration from the opening of the LOw Frequency ARray (LOFAR) but there are many other telescopes or upgrades that are now coming online. These include the E-VLA, e-MERLIN, e-VLBI, MWA, PAPER, ATA, eSMA, EMBRACE, SCUBA-2, APEX, IRAM, Yebes and ATCA (CABB). Some of these facilities are now beginning to produce their first results. This meeting aims to provide an overview of these first successes and indeed struggles(!), and highlight the future perspective and longer term goals of our community. These initial results will give a first taste of the science (and the challenges) that we will enjoy with the SKA. Several major elements of new telescopes like MEERKAT, ALMA, ASKAP, APERTIF, LWA, SRT and FAST are also expected to be producing some initial technical results around this time - these will also be covered in the programme of the meeting. In summary, we encourage presentations on results that use new or recently upgraded telescopes, or results that use new challenging techniques or address

  10. CMS MANAGEMENT MEETINGS

    CERN Multimedia

    Management Board Agendas and minutes of meetings of the Management Board are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 Collaboration Board Agendas and minutes of meetings of the Collaboration Board are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174 LHCC: Feedback from the CMS Referees, LHCC 97 February 25, 2009. The CMS LHCC referees met with representatives of CMS on 17-2-09, to review progress since the last November minireview. The main topics included  shutdown construction, maintenance and repairs;  status of the preshower detector; commissioning and physics analysis results from cosmic ray running and CSA08;   preparations for physics, off line analysis, computing, and data distribution. TOTEM management and the TOTEM referees then joined us for a joint session to examine the readiness of the TOTEM detector. Detector construction, maintenance, and repairs. The referees congratulate C...

  11. RH Department Information Meeting

    CERN Multimedia

    HR Department

    2010-01-01

    Dear Colleagues, HR Department would like to invite you to an information meeting which will be held on Thursday 30 September 2010 at 9:30 am in the Main Auditorium (Building 500)* A welcome coffee will be available from 9:00 a.m. The presentation will cover the CERN Competency Model which consists of the technical and behavioral competencies that are intrinsic to our Organization and its application in the various HR processes. This presentation will be followed by a questions & answers session. We look forward to seeing you all on 30 September! Best regards, Anne-Sylvie Catherin Head, Human Resources Department *This meeting will be simultaneously retransmitted and thereafter available at the following address: http://webcast.cern.ch.

  12. CMS MANANGEMENT MEETINGS

    CERN Multimedia

    Management Board Agendas and minutes of meetings of the Management Board are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 Collaboration Board Agendas and minutes of meetings of the Collaboration Board are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174 LHCC: Feedback from the CMS Referees, LHCC 97 February 25, 2009. The CMS LHCC referees met with representatives of CMS on 17-2-09, to review progress since the last November minireview. The main topics included shutdown construction, maintenance and repairs; status of the preshower detector; commissioning and physics analysis results from cosmic ray running and CSA08; preparations for physics, off line analysis, computing, and data distribution. TOTEM management and the TOTEM referees then joined us for a joint session to examine the readiness of the TOTEM detector. Detector construction, maintenance, and repairs. The referees congratulate CMS Management and the Detector Groups for the...

  13. CMS MANAGEMENT MEETINGS

    CERN Multimedia

    Jim Virdee

    Management Board Agendas and minutes of meetings of the Management Board are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 Collaboration Board Agendas and minutes of meetings of the Collaboration Board are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174 LHCC: Feedback from the CMS Referees, LHCC 97 February 25, 2009. The CMS LHCC referees met with representatives of CMS on 17-2-09, to review progress since the last November minireview. The main topics included  shutdown construction, maintenance and repairs;  status of the preshower detector; commissioning and physics analysis results from cosmic ray running and CSA08;   preparations for physics, off line analysis, computing, and data distribution. TOTEM management and the TOTEM referees then joined us for a joint session to examine the readiness of the TOTEM detector. Detector construction, maintenance, and repairs. The referees congratula...

  14. Improving the Rotterdam European Randomized Study of Screening for Prostate Cancer Risk Calculator for Initial Prostate Biopsy by Incorporating the 2014 International Society of Urological Pathology Gleason Grading and Cribriform growth.

    Science.gov (United States)

    Roobol, Monique J; Verbeek, Jan F M; van der Kwast, Theo; Kümmerlin, Intan P; Kweldam, Charlotte F; van Leenders, Geert J L H

    2017-07-01

    The survival rate for men with International Society of Urological Pathology (ISUP) grade 2 prostate cancer (PCa) without invasive cribriform (CR) and intraductal carcinoma (IDC) is similar to that for ISUP grade 1. If updated into the European Randomized Study of Screening for Prostate Cancer (ERSPC Rotterdam) risk calculator number 3 (RC3), this may further improve upfront selection of men who need a biopsy. To improve the number of possible biopsies avoided, while limiting undiagnosed clinically important PCa by applying the updated RC3 for risk-based patient selection. The RC3 is based on the first screening round of the ERSPC Rotterdam, which involved 3616 men. In 2015, histopathologic slides for PCa cases (n=885) were re-evaluated. Low-risk (LR) PCa was defined as ISUP grade 1 or 2 without CR/IDC. High-risk (HR) PCa was defined as ISUP grade 2 with CR/IDC and PCa with ISUP grade≥3. We updated the RC3 using multinomial logistic regression analysis, including data on age, PSA, digital rectal examination, and prostate volume, for predicting LR and HR PCa. Predictive accuracy was quantified using receiver operating characteristic analysis and decision curve analysis. Men without PCa could effectively be distinguished from men with LR PCa and HR PCa (area under the curve 0.70, 95% confidence interval [CI] 0.68-0.72 and 0.92, 95% CI 0.90-0.94). At a 1% risk threshold, the updated calculator would lead to a 34% reduction in unnecessary biopsies, while only 2% of HR PCa cases would be undiagnosed. A relatively simple risk stratification tool augmented with a highly sensitive contemporary pathologic biopsy classification would result in a considerable decrease in unnecessary prostate biopsies and overdiagnosis of potentially indolent disease. We improved a well-known prostate risk calculator with a new pathology classification system that better reflects disease burden. This new risk calculator allows individualized prediction of the chance of having (potentially

  15. Staff Association Information Meetings

    CERN Multimedia

    2011-01-01

    Staff Association Information Meetings: - Thursday 29 September at 2 p.m., Meyrin, Kjell Johnsen Auditorium, 30-7-017 (in French) - Friday 30 September at 10 a.m., Prévessin, BE Auditorium, 864-1-D02 (in French) - Monday 3 October at 2 p.m., Meyrin, IT Auditorium, 31-3-004 (in French) - Tuesday 4 October at 2 p.m., Meyrin, Filtration Plant, 222-R-001 (in English)   Staff Association

  16. China Meets G7

    Institute of Scientific and Technical Information of China (English)

    张贵福

    2004-01-01

    Parties held by the wealthy, seldom welcome poor guests. But last week China made it through the doors into a gathering of the world's richest countries. Jin Renqing, China's finance minister, and Zhou Xiaochuan, governor of the People's Bank of China, joined a meeting of the Group of Seven'on October. It is the first time that China has had direct talks with the club.

  17. 75 FR 52765 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2010-08-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Molecular Genetics B Study Section, October 3...

  18. 78 FR 64962 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-10-30

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Molecular Genetics A Study Section, October 21...

  19. 78 FR 64508 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-10-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Molecular Genetics B Study Section, October 02...

  20. 76 FR 37359 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Science.gov (United States)

    2011-06-27

    ... Meeting. Date: July 26-27, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications..., (Virtual Meeting). Contact Person: Helen R. Sunshine, PhD, Chief, Office of Scientific Review, National....859, Pharmacology, Physiology, and Biological Chemistry Research; 93.862, Genetics and...

  1. 103nd ACCU MEETING

    CERN Multimedia

    2014-01-01

    DRAFT Agenda for the meeting to be held on Tuesday 11 March 2014 at 9:15 a.m. in Room 60-6-002.   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. News from the CERN Management 5. Report on services from GS Department 6. Progress on Health Insurance for Users 7. Users Office News 8. Matters arising 9. Any Other Business 10. Election of a new ACCU Chairperson 11. Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail. Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives in ACCU are: Austria M. Jeitler manfred.jeitler@cern.ch Belgium M. Tytgat michael.tytgat@ce...

  2. 102nd ACCU MEETING

    CERN Document Server

    2013-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 4 December 2013 at 9:15 a.m. in Room 60-6-002.   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. News from the CERN Management 5. Report on services from GS Department 6. Progress on Health Insurance for Users 7. Users Office News 8. Reports from ACCU representatives on other Committees      a. Accommodation Facilities Working Group 9. Matters arising 10. Any Other Business 11. Election of a new ACCU Chairperson 12. Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail. Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical measures taken by CERN for the work of Users of the Laboratory....

  3. 107th ACCU Meeting

    CERN Multimedia

    2014-01-01

    Agenda for the meeting to be held on Tuesday 10 March 2015 at 9:15 a.m. in the Council Chamber (503-1-001): Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting News from the CERN Management Report on services from the GS Department Report on services from the IT Department a. Change of the portable phone contract from Sunrise to Swisscom Progress on Health Insurance for Users Users’ Office News Reports from ACCU representatives on other Committees a. Scientific Information Policy Board (SIPB) Matters arising Any Other Business Agenda for the next meeting Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail to ACCU.Secretary@cern.ch. Michael Hauschild (Secretary) ACCU is a forum for discussion between the CERN Management and representatives of the CERN Users in order to review the practical means...

  4. 105TH ACCU MEETING

    CERN Document Server

    2014-01-01

    DRAFT Agenda for the meeting to be held on Tuesday 9 September 2014 at 9.15 a.m. in room 60-6-002.   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. News from the CERN Management 5. Report on services from GS and IT Departments 6. Recent developments in dosimetry + medical services support for Users 7. Progress on Health Insurance for Users 8. Users’ Office News 9. Matters arising 10. Any Other Business 11. Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail.  Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are: Austria &nb...

  5. 98TH ACCU MEETING

    CERN Multimedia

    2012-01-01

    DRAFT Agenda for the meeting to be held on Friday 7 December 2012 at 9:15 a.m. in room 60-6-002.      Chairperson's remarks Adoption of the agenda Minutes of the previous meeting News from the CERN Management Report on services from GS department Status of Vidyo Health insurance issues Usage of Gate E for family members and opening times Users’ Office news Matters arising Any Other Business Agenda for the next meeting   Anyone wishing to raise any points under item 10 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch. Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are: Austria M. Jeitler manfred.jeitler@cern.ch Belgium C. Vander Velde (Chairperson) catherine....

  6. 108TH ACCU Meeting

    CERN Multimedia

    2015-01-01

    Agenda for the meeting to be held on Tuesday, 9 June 2015 at 9.15 a.m. in room Georges Charpak (Room F, 60-6-015): Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting Report on services from GS Department a. General Services b. Collaboration between CERN and HUG Report on services from IT Department 50th anniversary of the CERN Bulletin News from the CERN Management Progress on Health Insurance for Users Users’ Office News Reports from ACCU representatives on other Committees a. Restaurants' Supervisory committee Matters arising Any Other Business Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail to ACCU.Secretary@cern.ch. Michael Hauschild (Secretary) ACCU is a forum for discussion between the CERN Management and representatives of the CERN Us...

  7. 100TH ACCU MEETING

    CERN Document Server

    2013-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 4 June 2013 at 9:15 a.m. in room 60-6-002.   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. 25 years of ACCU 5. News from the CERN Management 6. Report on services from GS department 7. Status of the Health Insurance Project for Users 8. Users’ Office News 9. Public WiFi at CERN 10. Reports from ACCU representatives on other Committees a. Restaurants' Supervisory Committee 11. Matters arising 12. Any Other Business 13. Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail. Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Re...

  8. 104th ACCU MEETING

    CERN Multimedia

    2014-01-01

    DRAFT Agenda for the meeting to be held on Tuesday 3 June 2014 at 9:15 a.m. in Room 60-6-002.   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. News from the CERN Management 5. Report on services from GS and IT Departments 6. Progress on Health Insurance for Users 7. Users' Office News 8. Reports from ACCU representatives on other committees a. Academic Training Committee 9. Matters arising 10. Any Other Business 11. Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail. Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives in ACCU are: Austria M. Jeitler manf...

  9. 110th ACCU Meeting

    CERN Document Server

    2015-01-01

    Agenda for the meeting to be held on Tuesday, 8 December 2015​ at 9:15 a.m. in room Georges Charpak (Room F, 60-6-015).   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting News from the CERN Management Report on services from GS Department Report on services from IT department Strategic Communications Plan 2016-2020 Reports from ACCU representatives on other Committees Academic Training Committee Users’ Office News Matters arising Any Other Business Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson (Dragoslav.Lazic@cern.ch) or to the Secretary (ACCU.Secretary@cern.ch). Michael Hauschild (Secretary) ACCU is a forum for discussion between the CERN Management and representatives of the CERN users in order to review the practical means taken by CERN to support the...

  10. 99th ACCU meeting

    CERN Document Server

    2013-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 March 2013 at 9:15 a.m. in room 60-6-002.   1. Chairperson's remarks 2. Adoption of the agenda      3. Minutes of the previous meeting 4. News from the CERN Management 5. Report on services from GS department      6. Overview on Service Desk and Management status 7. CHIS/UNIQA health insurance issues 8. Users’ Office News 9. CERN Team & Collaboration Accounts 10. Diversity at CERN 11. Reports from ACCU representatives on other Committees       a. Academic Training Committee 12. Matters arising 13. Any Other Business 14. Agenda for the next meeting Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson in writing or by e-mail. Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and...

  11. 111th ACCU Meeting

    CERN Multimedia

    2016-01-01

    Agenda for the meeting to be held on Tuesday, 8 March 2016​ at 9.15 a.m. in room Georges Charpak (Room F, 60-6-015).   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting News from the CERN Management Report on services from SMB Department Report on services from IT department The new Microcosm Users’ Office News Matters arising Any Other Business Election of ACCU Chairperson Agenda for the next meeting   Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson (Dragoslav.Lazic@cern.ch) or to the Secretary (ACCU.Secretary@cern.ch). Michael Hauschild (Secretary) ACCU is a forum for discussion between the CERN Management and representatives of the CERN users in order to review the practical means taken by CERN to support the work of Users of the Laboratory. The User Representatives to ACCU are:...

  12. 112th ACCU Meeting

    CERN Multimedia

    2016-01-01

    Agenda for the meeting to be held on Tuesday, 7 June 2016​ at 9.15 a.m. in room Georges Charpak (Room F, 60-6-015).   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting News from the CERN Management The new International Relations sector Report on services from IT department Results of Users' Survey on Communication Questions and Answers on UBS Issues Report on services from SMB Department Users’ Office News Matters arising Any Other Business Agenda for the next meeting Anyone wishing to raise any points under “Any Other Business” is invited to send them to the Chairperson (Dragoslav.Lazic@cern.ch) or to the Secretary (ACCU.Secretary@cern.ch). Michael Hauschild (Secretary) ACCU is a forum for discussion between the CERN Management and representatives of the CERN users in order to review the practical means taken by CERN to support the work of Use...

  13. Highlights: Spring Council Meeting

    Science.gov (United States)

    Council members present at the May 24, 1981, meeting were Keiiti Aki, Steven Burges (for Jim Wallis), Peter S. Eagleson, E. R. Engdahl, Charles E. Helsley, James R. Heirtzler, Carl Kisslinger, Leslie H. Meredith, Chris N. K. Mooers, Norman F. Ness, Marcia M. Neugebauer, James J. O'Brien, Richard Rapp, Carl Sagan, James C. Savage, Joseph V. Smith, Fred Spilhaus, Donald L. Turcotte, James A. Van Allen, J. Tuzo Wilson, and Jay Winston (for Elmar R. Reiter until his arrival at 6:50 P.M.). David Strangway, representing the Canadian Geophysical Union, and Peter Steinhauser, representing the European Geophysical Society, were special observers at the meeting. Council meetings are open, and a number of section secretaries, committee chairmen, journal editors, and other members attended. The following major actions were adopted by the Council:The experiment of publishing oceanography and lower-atmosphere papers in JGR Green issues alternate to those containing upper-atmosphere papers will be continued through 1982. From preliminary indications the experiment seems to be working, but a full year of data, including a renewal cycle, is needed to assess the success of the experiment. Final decision will be made prior to the 1983 dues notices.

  14. Planning and conducting meetings effectively, part I: planning a meeting.

    Science.gov (United States)

    Harolds, Jay

    2011-12-01

    Meetings are held by leaders for many purposes, including conveying information, raising morale, asking for opinions, brain storming, making people part of the problem-solving process, building trust, getting to a consensus, and making decisions. However, many meetings waste time, some undermine the leader's power, and some decrease morale. Part I of this series of articles gives some tips on basic planning for decision-making meetings. Part II of this series of articles analyzes selected components of decision-making meetings. Part III of this series will be on how the chairperson keeps decision-making meetings on track to make them efficient and productive.

  15. 76 FR 3629 - Regular Meeting

    Science.gov (United States)

    2011-01-20

    ... meeting of the Board will be held at the offices of the Farm Credit Administration in McLean, Virginia, on...Lean, Virginia 22102. SUPPLEMENTARY INFORMATION: This meeting of the Board will be open to the ] public... CORPORATION Farm Credit System Insurance Corporation Board Regular Meeting SUMMARY: Notice is hereby given of...

  16. 78 FR 4847 - Board Meeting

    Science.gov (United States)

    2013-01-23

    ... CORPORATION Board Meeting AGENCY: Farm Credit System Insurance Corporation. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). DATE AND TIME: The meeting of the Board will be held at the offices of the Farm Credit Administration in McLean, Virginia,...

  17. Genetic Breakthrough

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A new calf breeding technique shows promise for treating malignant tumors Chinese scientists have successfully bred a genetically altered cow capable of producing cancer-curing proteins for human beings.

  18. Mitochondrial genetics

    OpenAIRE

    Chinnery, Patrick Francis; Hudson, Gavin

    2013-01-01

    Introduction In the last 10 years the field of mitochondrial genetics has widened, shifting the focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) variation in a growing spectrum of human disease. The aim of this review is to guide the reader through some key concepts regarding mitochondria before introducing both classic and emerging mitochondrial disorders. Sources of data In this article, a review of the current mitochondrial genetics literature was con...

  19. Nature meets nurture: molecular genetics of gastric cancer

    NARCIS (Netherlands)

    Milne, A.N.; Carneiro, F.; O'Morain, C.; Offerhaus, G.J.A.

    2009-01-01

    The immensity of genes and molecules implicated in gastric carcinogenesis is overwhelming and the relevant importance of some of these molecules is too often unclear. This review serves to bring us up-to-date with the latest findings as well as to look at the larger picture in terms of how to tackle

  20. Genetic enhancement, human nature, and rights.

    Science.gov (United States)

    McConnell, Terrance

    2010-08-01

    Authors such as Francis Fukuyama, the President's Council on Bioethics, and George Annas have argued that biotechnological interventions that aim to promote genetic enhancement pose a threat to human nature. This paper clarifies what conclusions these critics seek to establish, and then shows that there is no plausible account of human nature that will meet the conditions necessary to support this position. Appeals to human nature cannot establish a prohibition against the pursuit of genetic enhancement.

  1. Philosophical Research on Genetically Modified Food

    OpenAIRE

    2015-01-01

    This study mainly analyzes the essential features of transgenic technology from the angle of philosophy, explaining the essential characteristics of transgenic technology, so as to promote the better development of genetically modified food. With the technical improvement, genetically modified food is no longer strange, which has been applied in the production of our life. Compared with the traditional biological breeding, transgenic food has changed significantly in nature. Trying to meet th...

  2. Automatic analysis of multiparty meetings

    Indian Academy of Sciences (India)

    Steve Renals

    2011-10-01

    This paper is about the recognition and interpretation of multiparty meetings captured as audio, video and other signals. This is a challenging task since the meetings consist of spontaneous and conversational interactions between a number of participants: it is a multimodal, multiparty, multistream problem. We discuss the capture and annotation of the Augmented Multiparty Interaction (AMI) meeting corpus, the development of a meeting speech recognition system, and systems for the automatic segmentation, summarization and social processing of meetings, together with some example applications based on these systems.

  3. LLW Forum meeting report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-12-31

    This document reports the details of the Quarterly Meeting of the Low- Level Radioactive Waste Forum held in San Diego, California during January 23-25, 1991. Topics discussed include: State and Compact Progress Reports; Legal Updates; Update on Technical Assistance; Advanced Notice of Proposed Rulemaking Regarding Surcharge Rebates; Update on TCC Activities; NRC Update; Disposal of Commercial Mixed Waste; Update on EPA Activities; ACNW Working Group on Mixed Waste; National Profile on Mixed Waste; Commercial Perspective on Mixed Waste; Update on DOT Activities; Source Terms; Materials and Waste; Storage: and Waste Acceptance Criteria and Packaging.

  4. LLW Forum meeting report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    This report summarizes the Low-Level Radioactive Waste Forum (LLW Forum) meeting on May 29 through May 31, 1996.The LLW Forum is an association of state and compact representatives, appointed by governors and compact commissions, established to facilitate state and compact implementation of the Low-Level Waste Policy Act of 1980 and the Low-Level Radioactive Waste Policy Amendments Act of 1985 and to promote the objectives of low-level radioactive waste regional compacts. The LLW forum provides an opportunity for state and compact officials to share information with one another and to exchange views with officials of federal agencies and other interested parties.

  5. 77 FR 32652 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-01

    ... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings...: Genes, Genomes, and Genetics Integrated Review Group Molecular Genetics A Study Section. Date: June 25... for Scientific Review Special Emphasis Panel Skeletal Muscle Biology, Physiology and Disease....

  6. 78 FR 109 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-01-02

    ... Genetics Integrated Review Group Molecular Genetics B Study Section. Date: January 31-February 1, 2013... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings...

  7. 77 FR 25487 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-04-30

    ..., Genomes, and Genetics Integrated Review Group; Molecular Genetics B Study Section. Date: May 26-27, 2012... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings...

  8. 76 FR 370 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-04

    ... 20892, 301-435-2270, wanimaqs@csr.nih.gov . Name of Committee: Genes, Genomes, and Genetics Integrated Review Group; Molecular Genetics B Study Section. Date: February 1-2, 2011. Time: 8 a.m. to 5 p.m. Agenda... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings...

  9. 76 FR 58284 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-09-20

    ... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings... Committee: Vascular and Hematology Integrated Review Group; Vascular Cell and Molecular Biology Study..., Genomes, and Genetics Integrated Review Group; Genetics of Health and Disease Study Section. Date: October...

  10. 78 FR 25754 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-02

    ...-1727, schneidd@csr.nih.gov . Name of Committee: Genes, Genomes, and Genetics Integrated Review Group; Molecular Genetics B Study Section. Date: May 29-30, 2013. Time: 7:00 p.m. to 6:30 p.m. Agenda: To review... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings...

  11. 78 FR 59361 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-26

    ..., Genomes, and Genetics Integrated Review Group; Molecular Genetics A Study Section. Date: October 21-22... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings... . Name of Committee: Molecular, Cellular and Developmental Neuroscience Integrated Review Group; Cellular...

  12. 77 FR 52338 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-08-29

    ..., petersonjt@csr.nih.gov . Name of Committee: Genes, Genomes, and Genetics Integrated Review Group; Molecular Genetics B Study Section. Date: September 27-28, 2012. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings...

  13. 77 FR 2739 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-01-19

    ... Genetics Integrated Review Group; Molecular Genetics A Study Section. Date: February 13-14, 2012. Time: 8 a... HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings... Integrated Review Group; Kidney Molecular Biology and Genitourinary Organ Development. Date: February 9, 2012...

  14. NEWS: AAPT Summer Meeting

    Science.gov (United States)

    Mellema, Steve

    2000-11-01

    The 2000 Summer Meeting of the American Association of Physics Teachers (AAPT) was held from 28~July-2~August at the University of Guelph in Ontario, Canada. Despite somewhat rainy weather throughout the week, the annual gathering was an enjoyable one, filled with interesting talks on the state of physics education in North America. Using a new scheduling format for the summer meeting, all of the paid workshops and tutorials were held on Saturday and Sunday 29-30 July. The invited and contributed papers for the main AAPT meeting were then presented on Monday, Tuesday and Wednesday. As had been done in 1999 in San Antonio, a two-day tandem meeting dedicated to Physics Education Research (PER) was held on Wednesday and Thursday 2-3 August, immediately after the main AAPT meeting. Over the three days of the main meeting, 60 sessions were held under the sponsorship of various AAPT committees. These included sessions (numbers in parentheses) organized by the committees on Apparatus (1), Astronomy Education (3), Awards (2), Computers (5), Graduate Education (2), High Schools (1), History and Philosophy (1), Instructional Media (3), International Education (1), Laboratories (2), Pre-High School Education (2), Programs (4), Professional Concerns (6), Research in Physics Education (8), Science Education for the Public (2), Two-Year Colleges (5), Undergraduate Education (7) and Women in Physics (4). Figure 1. Guelph Church of Our Lady. The main meeting opened on Sunday evening with an invited lecture by Dr John J Simpson from the host institution, the University of Guelph, describing the Sudbury Neutrino Observatory. At the ceremonial session that began the activities on Monday morning, recognition was given to Clifford Swartz for his almost 30 years of service as Editor of the AAPT journal, The Physics Teacher. This was followed by an invited talk by Jim Nelson from Seminole County Public School in Florida, who received the Excellence in Pre-College Teaching Award. The

  15. Virtual anthropology meets biomechanics.

    Science.gov (United States)

    Weber, Gerhard W; Bookstein, Fred L; Strait, David S

    2011-05-17

    A meeting in Vienna in October 2010 brought together researchers using Virtual Anthropology (VA) and Finite Element Analysis (FEA) in order to explore the benefits and problems facing a collaboration between the two fields. FEA is used to test mechanical hypotheses in functional anatomy and VA complements and augments this process by virtue of its tools for acquiring data, for segmenting and preparing virtual specimens, and for generating reconstructions and artificial forms. This represents a critical methodological advance because geometry is one of the crucial inputs of FEA and is often the variable of interest in functional anatomy. However, we currently lack tools that quantitatively relate differences in geometry to differences in stress and strain, or that evaluate the impact on FEA of variation within and between biological samples. Thus, when comparing models of different geometry, we do not currently obtain sufficiently informative answers to questions such as "How different are these models, and in what manner are they different? Are they different in some anatomical regions but not others?" New methodologies must be developed in order to maximize the potential of FEA to address questions in comparative and evolutionary biology. In this paper we review these and other important issues that were raised during our Vienna meeting.

  16. The 50th Annual Maize Genetics Conference

    Energy Technology Data Exchange (ETDEWEB)

    Cone, Karen

    2014-03-26

    The 50th Annual Maize Genetics Conference was held February 27 - March 2, 2008 at the Marriott Wardman Park Hotel in Washington, D.C. As the golden anniversary of the Conference and coinciding with the release of a draft of the maize genome sequence, this was a special meeting. To publicize this unique occasion, meeting organizers hosted a press conference, which was attended by members of the press representing science and non-science publications, and an evening reception at the Smithsonian National Museum of Natural History, where the draft sequence was announced and awards were presented to Dr. Mary Clutter and Senator Kit Bond to thank them for their outstanding contributions to maize genetics and genomics research. As usual, the Conference provided an invigorating forum for exchange of recent research results in many areas of maize genetics, e.g., cytogenetics, development, molecular genetics, transposable element biology, biochemical genetics, and genomics. Results were shared via both oral and poster presentations. Invited talks were given by four distinguished geneticists: Vicki Chandler, University of Arizona; John Doebley, University of Wisconsin; Susan Wessler, University of Georgia; and Richard Wilson, Washington University. There were 46 short talks and 241 poster presentations. The Conference was attended by over 500 participants. This included a large number of first-time participants in the meeting and an increasingly visible presence by individuals from underrepresented groups. Although we do not have concrete counts, there seem to be more African American, African and Hispanic/Latino attendees coming to the meeting than in years past. In addition, this meeting attracted many participants from outside the U.S. Student participation continues to be hallmark of the spirit of free exchange and cooperation characteristic of the maize genetics community. With the generous support provided by DOE, USDA NSF, and corporate/private donors, organizers were

  17. Genetic GIScience

    DEFF Research Database (Denmark)

    Jacquez, Geoffrey; Sabel, Clive E; Shi, Chen

    2015-01-01

    The exposome, defined as the totality of an individual's exposures over the life course, is a seminal concept in the environmental health sciences. Although inherently geographic, the exposome as yet is unfamiliar to many geographers. This article proposes a place-based synthesis, genetic...... geographic information science (genetic GIScience), that is founded on the exposome, genome+, and behavome. It provides an improved understanding of human health in relation to biology (the genome+), environmental exposures (the exposome), and their social, societal, and behavioral determinants (the behavome......). Genetic GIScience poses three key needs: first, a mathematical foundation for emergent theory; second, process-based models that bridge biological and geographic scales; third, biologically plausible estimates of space?time disease lags. Compartmental models are a possible solution; this article develops...

  18. Meeting Report: The Twelfth International Mouse Genome Conference

    Energy Technology Data Exchange (ETDEWEB)

    Manolakou, Katerina; Cross, Sally H.; Simpson, Eleanor H.; Jackson, Ian J.

    1998-10-01

    The annual International Mouse Genome Conference (IMGC) is where, scientifically speaking, classical mouse genetics meets the relative newcomer of genomics. The 12th meeting took place last October in the delightful Bavarian village of Garmisch-Partenkirchen, and we were greeted by the sight on the mountains of the first snowfall of the season. However the discussions left little time for exploration. Minds of participants in Garmisch were focused by a recent document produced by the NIH and by discussions within other funding agencies worldwide. If implemented, the proposals will further enhance the status of the mouse as the principal model for study of the function of the human genome.

  19. Identifying genetics and genomics nursing competencies common among published recommendations.

    Science.gov (United States)

    Greco, Karen E; Salveson, Catherine

    2009-10-01

    The purpose of this article is to identify published recommendations for genetics and genomics competencies or curriculum for nurses in the United States and to summarize genetic and genomic nursing competencies based on common themes among these documents. A review of the literature between January 1998 and June 2008 was conducted. Efforts were also made to access the gray literature. Five consensus documents describing recommendations for genetics and genomics competencies for nurses meeting inclusion criteria were analyzed. Twelve genetics and genomics competencies were created based on common themes among the recommendations. These competencies include: demonstrate an understanding of basic genetic and genomic concepts, provide and explain genetic and genomic information, refer to appropriate genetics professionals and services, and identify the limits of one's own genetics and genomics expertise. The competencies represent fundamental genetics and genomics competencies for nurses on the basis of common themes among several consensus recommendations identified in the literature.

  20. 45 CFR 702.53 - Closed meetings.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Closed meetings. 702.53 Section 702.53 Public..., REPORTS, AND MEETINGS OF THE COMMISSION Meetings § 702.53 Closed meetings. (a) The Commission may close a portion or portions of a meeting and withhold information pertaining to such meeting when it...

  1. Constraints meet concurrency

    CERN Document Server

    Mauro, Jacopo

    2014-01-01

    This book describes the benefits that emerge when the fields of constraint programming and concurrency meet. On the one hand, constraints can be used in concurrency theory to increase the conciseness and the expressive power of concurrent languages from a pragmatic point of view. On the other hand, problems modeled by using constraints can be solved faster and more efficiently using a concurrent system. Both directions are explored providing two separate lines of development. Firstly the expressive power of a concurrent language is studied, namely Constraint Handling Rules, that supports constraints as a primitive construct. The features of this language which make it Turing powerful are shown. Then a framework is proposed to solve constraint problems that is intended to be deployed on a concurrent system. For the development of this framework the concurrent language Jolie following the Service Oriented paradigm is used. Based on this experience, an extension to Service Oriented Languages is also proposed in ...

  2. AMFIE Information meetings

    CERN Multimedia

    2012-01-01

    Meetings open to all members of personnel (users, staff, etc) as well as retired staff.   Public presentation with question/answer session Wednesday 18 April 2012 From 12:00 to 13:00 In room 40-2-A01 Private consultations on appointment Wednesday 18 April 2012 From 10:00 to 11:30 and from 14:00 to 17:30 In room 5-5-028 AMFIE is a cooperative society open exclusively to international civil servants. It is managed by a group of active and retired international civil servants. Created in 1990 as a fully licensed financial institution, it is subject to the laws and regulations which govern the activities of Luxembourg's financial sector. The Cooperative offers its members a broad range of financial services and products at little or no cost in the six currencies available to account holders (EUR, CHF, GBP, USD, CAD, AUD). More information here. HR Department Tel. 74125

  3. Philosophical Research on Genetically Modified Food

    Directory of Open Access Journals (Sweden)

    Meng Zhang

    2015-02-01

    Full Text Available This study mainly analyzes the essential features of transgenic technology from the angle of philosophy, explaining the essential characteristics of transgenic technology, so as to promote the better development of genetically modified food. With the technical improvement, genetically modified food is no longer strange, which has been applied in the production of our life. Compared with the traditional biological breeding, transgenic food has changed significantly in nature. Trying to meet the basic needs of human beings to achieve the common development of mankind, so as to achieve consensus between the scientific field and consumer is the purpose of exploring the philosophical problems of genetically modified food.

  4. Genetic risk factors for autoimmune diseases

    NARCIS (Netherlands)

    Feltkamp, T.E.W.; Aarden, L.A.; Lucas, C.J.; Verweij, C.L.; Vries, R.R.P. de

    1999-01-01

    In most autoimmune diseases multigenic factors play a significant role in pathogenesis. Progress in identifying these genetic factors, many of which are located outside the major histocompatibility complex, was the subject of a recent meeting. Chemicals/CAS: Interleukin-10, 130068-27-8; Transforming

  5. Modernization, Population Dispersion, and Papago Genetic Integrity

    Science.gov (United States)

    Smith, David G.

    1972-01-01

    That residents of Papago villages were less closely related in the 19th century than during recent decades is considered in historical and genetic perspectives. A preliminary version of this paper was read at the annual meeting of the American Anthropological Association, New York City, 1971. (FF)

  6. Telemedicine uptake among Genetics Professionals in Europe : room for expansion

    NARCIS (Netherlands)

    Otten, Ellen; Birnie, Erwin; Lucassen, Anneke M.; Ranchor, Adelita V.; Van Langen, Irene M.

    2016-01-01

    Today's economic challenges and the changing landscape of clinical genetics are forcing us to consider alternative ways of providing genetic services, to comply with budget limitations and at the same time meeting the demands of increasing patient numbers and patient-centered care delivery. Telegene

  7. Enhance the Team Status Meeting

    Science.gov (United States)

    2014-12-01

    collection and analysis tool chosen by the team : the Process Dashboard © 1998-2014 Tuma Solutions, LLC. Using this format , the PRT teams are now getting...status meetings of those teams coached by the NAVAIR PRT have evolved into more relevant, easier to understand, and more visually interesting formats ...support, this submission to Open Forum highlights the team status meeting. These meetings help keep a team aware, engaged, and on-track. Their content

  8. Fifteenth LAMPF users group meeting

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, D.R.F. (comp.)

    1982-03-01

    The Fifteenth LAMPF Users Group Meeting was held November 2-3, 1981 at the Clinton P. Anderson Meson Physical Facility. The program of papers scheduled to be presented was amended to include a Report from Washington by Clarence R. Richardson, US Department of Energy. The general meeting ended with a round-table working group discussion concerning the Planning for a Kaon Factory. Individual items from the meeting were prepared separately for the data base.

  9. RNA genetics

    Energy Technology Data Exchange (ETDEWEB)

    Domingo, E. (Instituto de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Canto Blanco, Madrid (ES)); Holland, J.J. (California Univ., San Diego, La Jolla, CA (USA). Dept. of Biology); Ahlquist, P. (Wisconsin Univ., Madison, WI (USA). Dept. of Plant Pathology)

    1988-01-01

    This book contains the proceedings on RNA genetics: RNA-directed virus replication Volume 1. Topics covered include: Replication of the poliovirus genome; Influenza viral RNA transcription and replication; and Relication of the reoviridal: Information derived from gene cloning and expression.

  10. Genetic counseling

    Science.gov (United States)

    ... MF, eds. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice . 7th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 30. Review Date 1/25/2016 Updated by: Chad Haldeman-Englert, MD, FACMG, Fullerton Genetics Center, Asheville, NC. Review provided by VeriMed Healthcare ...

  11. FRAUDULENT ACTIVITIES USING VIRTUAL MEETINGS

    Directory of Open Access Journals (Sweden)

    Anne James

    2013-05-01

    Full Text Available This paper investigates fraudulent and illegal activities that take place through virtual meeting systems. The first section gives an introduction to the problem. Section two describes some cases of fraudulent activity using virtual meeting systems. Section three explores some means of capturing such fraudulent activities so thatcriminals can be brought to justice. Section four provides a solution for capturing virtual meeting conversations in a way that could be admissible in court. Section five discusses tell-tale signs that indicates that a conversation maybe fraudulent. Section six discusses Artificial Intelligence (AI techniques that might be used to detectvirtual meeting crime. Section seven discusses the conclusion to the paper.

  12. 77 FR 2541 - Board Meeting

    Science.gov (United States)

    2012-01-18

    ... meetings, persons requiring assistance should make arrangements in advance. The matters to be considered at... Investment Portfolio Review of Insurance Premium Rates Overview of Communications Crisis Plan with...

  13. 75 FR 47312 - Board Meeting; Sunshine Act Meetings

    Science.gov (United States)

    2010-08-05

    ... From the Federal Register Online via the Government Publishing Office INTER-AMERICAN FOUNDATION Board Meeting; Sunshine Act Meetings Time and Date: August 9, 2010, 8:30 a.m.-5:30 p.m.. Place: 101 Constitution Avenue, Washington, DC 20001. Status: Closed session as provided in 22 CFR 1004.4(f). Matters...

  14. Annual Information Meeting of the Pension Fund (General Meeting)

    CERN Multimedia

    2012-01-01

    All members and beneficiaries of the Pension Fund are invited to attend the Annual Information Meeting to be held in the CERN Council Chamber on Wednesday 12 September 2012 from 10 am to 12 pm * Coffee and croissants will be served prior to the meeting as of 9:30 am. *

  15. Is homosexuality genetic? A critical review and some suggestions.

    Science.gov (United States)

    McGuire, T R

    1995-01-01

    Genetic analysis of behavioral differences among human beings requires both careful experimental design and appropriate genetic models. Any genetic study must be (1) valid and precise measures of individual differences, (2) appropriate methods to ascertain biological relationships, (3) research subjects who have been randomly recruited, (4) appropriate sample sizes, and (5) appropriate genetic models to interpret the data. In addition, the researchers must exercise caution in interpreting biosocial effects from the observed phenotypic correlations. To date, all studies of the genetic basis of sexual orientation of men and women have failed to meet one or more or any of the above criteria.

  16. Meeting increased demand.

    Science.gov (United States)

    Blair, Andrew

    2004-07-01

    New Zealand is a little country with a little economy but with a population that's rapidly aging. New Zealand's population is only 4.3 million people. It's GDP is only $US58.6 billion (2002). New Zealand's expenditure on health as a percentage of GDP is not out of line with that of other countries. As a nation we have been increasing expenditure on health over recent years. In 1990 we spent 7% of GDP on health. In 1995 that increased to 7.65% and is now 8.3%. However, in per capita terms our expenditure on health does not compare so well with like countries. The size of New Zealand's economy is restricting what our country spends on health. Health is already the second highest demand on the New Zealand tax dollar. The tolerance of New Zealanders would be challenged if a Government attempted to increase taxes further to meet the growing demands for expenditure on health, but at the same time the population's expectations are increasing. This is the challenging situation we face today. What lies ahead? Like all industrialized countries New Zealand is facing an aging population. The population below age 40 is decreasing, but it is increasing significantly over that age. 16% of the population is currently aged over 60. By 2051 this proportion will almost double to just over 31%. Coupled with the aging population is increased awareness and expectations, as access to options for treatment and technology becomes readily accessible to the population through such media as the internet. The extent of the impact of the aging population can be clearly represented by focusing on one specialty such as orthopaedics. The New Zealand Orthopaecic Association undertook a study in July 2003 which concluded (among other things) that as a result of the projected aging of the population, over the next 50 years: Musculo-skeletal operations will increase by over 30%. The number of hip replacements will nearly double. The incidence of osteoporosis will increase by a massive 201%. The number

  17. On the efficiency of the hybrid and the exact second-order sampling formulations of the EnKF: a reality-inspired 3-D test case for estimating biodegradation rates of chlorinated hydrocarbons at the port of Rotterdam

    Science.gov (United States)

    Gharamti, Mohamad E.; Valstar, Johan; Janssen, Gijs; Marsman, Annemieke; Hoteit, Ibrahim

    2016-11-01

    This study considers the assimilation problem of subsurface contaminants at the port of Rotterdam in the Netherlands. It involves the estimation of solute concentrations and biodegradation rates of four different chlorinated solvents. We focus on assessing the efficiency of an adaptive hybrid ensemble Kalman filter and optimal interpolation (EnKF-OI) and the exact second-order sampling formulation (EnKFESOS) for mitigating the undersampling of the estimation and observation errors covariances, respectively. A multi-dimensional and multi-species reactive transport model is coupled to simulate the migration of contaminants within a Pleistocene aquifer layer located around 25 m below mean sea level. The biodegradation chain of chlorinated hydrocarbons starting from tetrachloroethene and ending with vinyl chloride is modeled under anaerobic environmental conditions for 5 decades. Yearly pseudo-concentration data are used to condition the forecast concentration and degradation rates in the presence of model and observational errors. Assimilation results demonstrate the robustness of the hybrid EnKF-OI, for accurately calibrating the uncertain biodegradation rates. When implemented serially, the adaptive hybrid EnKF-OI scheme efficiently adjusts the weights of the involved covariances for each individual measurement. The EnKFESOS is shown to maintain the parameter ensemble spread much better leading to more robust estimates of the states and parameters. On average, a well tuned hybrid EnKF-OI and the EnKFESOS respectively suggest around 48 and 21 % improved concentration estimates, as well as around 70 and 23 % improved anaerobic degradation rates, over the standard EnKF. Incorporating large uncertainties in the flow model degrades the accuracy of the estimates of all schemes. Given that the performance of the hybrid EnKF-OI depends on the quality of the background statistics, satisfactory results were obtained only when the uncertainty imposed on the background

  18. On the efficiency of the hybrid and the exact second-order sampling formulations of the EnKF: a reality-inspired 3-D test case for estimating biodegradation rates of chlorinated hydrocarbons at the port of Rotterdam

    KAUST Repository

    El Gharamti, Mohamad

    2016-11-15

    This study considers the assimilation problem of subsurface contaminants at the port of Rotterdam in the Netherlands. It involves the estimation of solute concentrations and biodegradation rates of four different chlorinated solvents. We focus on assessing the efficiency of an adaptive hybrid ensemble Kalman filter and optimal interpolation (EnKF-OI) and the exact second-order sampling formulation (EnKFESOS) for mitigating the undersampling of the estimation and observation errors covariances, respectively. A multi-dimensional and multi-species reactive transport model is coupled to simulate the migration of contaminants within a Pleistocene aquifer layer located around 25 m below mean sea level. The biodegradation chain of chlorinated hydrocarbons starting from tetrachloroethene and ending with vinyl chloride is modeled under anaerobic environmental conditions for 5 decades. Yearly pseudo-concentration data are used to condition the forecast concentration and degradation rates in the presence of model and observational errors. Assimilation results demonstrate the robustness of the hybrid EnKF-OI, for accurately calibrating the uncertain biodegradation rates. When implemented serially, the adaptive hybrid EnKF-OI scheme efficiently adjusts the weights of the involved covariances for each individual measurement. The EnKFESOS is shown to maintain the parameter ensemble spread much better leading to more robust estimates of the states and parameters. On average, a well tuned hybrid EnKF-OI and the EnKFESOS respectively suggest around 48 and 21 % improved concentration estimates, as well as around 70 and 23 % improved anaerobic degradation rates, over the standard EnKF. Incorporating large uncertainties in the flow model degrades the accuracy of the estimates of all schemes. Given that the performance of the hybrid EnKF-OI depends on the quality of the background statistics, satisfactory results were obtained only when the uncertainty imposed on the background

  19. Evaluación de las propiedades psicométricas de la versión española del Rotterdam Symptom Checklist para medir calidad de vida en pacientes oncológicos

    Directory of Open Access Journals (Sweden)

    Agra Yolanda

    1999-01-01

    Full Text Available FUNDAMENTO: el presente trabajo aborda la validación de la versión española del Rotterdam Symptom Checklist (RSCL para evaluar la calidad de vida de las personas con cáncer. El objetivo es evaluar las propiedades psicométricas del cuestionario y su equivalencia con la versión original inglesa. MÉTODO: Se cumplimentó el cuestionario por 162 pacientes oncológicos terminales y 59 pacientes sometidos a quimioterapia. Se evaluó su estructura interna a través de análisis factorial confirmatorio en pacientes oncológicos terminales, capacidad discriminante según situación clínica de los mismos, consistencia interna en ambas muestras y sensibilidad a los cambios, repitiendo el cuestionario tres veces a los pacientes sometidos a quimioterapia. RESULTADOS: Los pacientes terminales presentaron peor puntuación que los sometidos a quimioterapia para todas las escalas excepto la psicológica. El análisis factorial mostró una estructura interna similar a la versión original. La consistencia interna fue ³ 0,70 para todas las escalas y ³ 0,50 para las subescalas excepto la de quimioterapia. Se encontraron diferencias de puntuación (p<0,05 para todas las subescalas (excepto la psicológica antes y después del tratamiento con quimioterapia. CONCLUSIONES: La similitud de las propiedades psicométricas de la versión española del RSCL con la versión original indica su utilidad como medida subjetiva de bienestar en la investigación clínica de personas con cáncer.

  20. Rotterdam Aphasia Therapy Study (RATS – 3: “The efficacy of intensive cognitive-linguistic therapy in the acute stage of aphasia”; design of a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Nouwens Femke

    2013-01-01

    Full Text Available Abstract Background Aphasia is a severely disabling condition occurring in 20 to 25% of stroke patients. Most patients with aphasia due to stroke receive speech and language therapy. Methodologically sound randomised controlled trials investigating the effect of specific interventions for patients with aphasia following stroke are scarce. The currently available evidence suggests that intensive speech and language therapy is beneficial for restoration of communication, but the optimal timing of treatment is as yet unclear. In the Rotterdam Aphasia Therapy Study-3 we aim to test the hypothesis that patients with aphasia due to stroke benefit more from early intensive cognitive-linguistic therapy than from deferred regular language therapy. Methods/design In a single blinded, multicentre, randomised controlled trial, 150 patients with first ever aphasia due to stroke will be randomised within two weeks after stroke to either early intensive cognitive-linguistic therapy (Group A or deferred regular therapy (Group B. Group A will start as soon as possible, at the latest two weeks after stroke, with a four week period of one hour a day treatment with cognitive-linguistic therapy. In Group B professional speech and language therapy is deferred for four weeks. After this period, patients will follow the conventional procedure of speech and language therapy. Participants will be tested with an extensive linguistic test battery at four weeks, three months and six months after inclusion. Primary outcome measure is the difference in score between the two treatment groups on the Amsterdam-Nijmegen Everyday Language Test, a measure of everyday verbal communication, four weeks after randomisation. Trial registration This trial is registered in the Dutch Trial Register (http://www.trialregister.nl, NTR3271.

  1. Report of a Working Group on Solanaceae : first meeting of the Working group and ad hoc meeting of the database managers, 14-17 Februari 2012, Menemen, Turkey

    OpenAIRE

    2012-01-01

    The Solanaceae Working Group (WG) of the European Cooperative Programme for Plant Genetic Resources (ECPGR) has established six databases for the crops that form its mandate. These include three major crops (Eggplant, Pepper and Tomato) and three minor crops (Cyphomandra, Pepino and Physalis). The ad hoc meeting of the Solanaceae Database (DB) Managers took place on 14 February 2012, prior to the meeting of the whole Solanaceae WG from 15 to 17 February. Willem van Dooijeweert, Chair of the W...

  2. 《鹿特丹规则》的“单证托运人”之规定——兼与FOB卖方权益零保护观点之磋商%Provisions of documentary shipper in the Rotterdam Rules-- discussion of the view of FOB seller's rights and interests have no protection

    Institute of Scientific and Technical Information of China (English)

    张玉卿

    2012-01-01

    Based on the review of the provisions on the issue that to whom the B/L should be issued as stipulated in the Hague Rules, the Hamburg Rules and the Maritime Code of the PRC,and the analysis of Art. 35 of the United Nations Convention on Contract for the International Carriage of Goods Wholly or Partly by Sea (the Rotterdam Rules), the paper reveals that the Documentary Shipper established by the Rotterdam Rules can be used by the FOB seller for the entitlement to obtaining the transport document (bills of lading) or the electronic transport records for the protection of its interest. This is a gap-filling of the previous international convention and domestic laws and a new development in international maritime law. At the same time, this paper puts proposals for FOB exporters such as how to deal with the relationship between the sales contract and the contract of carriage, how to deal with the issuance of bill of lading under the Rotterdam Rules so as to reduce the risk in its international sale of goods.%通过对几个海上货物运输公约及《中华人民共和国海商法》相关条款的理解,分析海上运输合同、买卖合同以及付款方式,进而指出在《鹿特丹规则》下FOB卖方的地位。与此同时,提出出口商应如何处理买卖合同与海上运输合同的关系,如何处理提单签发问题,如何减少风险,维护自己的权益。

  3. Annotating and measuring meeting behavior

    NARCIS (Netherlands)

    van Dijk, Elisabeth M.A.G.; Nijholt, Antinus; Heylen, Dirk K.J.; Noldus, L.P.J.J.; Grieco, F; Loijens, L.W.S.; Zimmerman, P.H.

    2005-01-01

    Within the AMI (Augmented Multi-party Interaction) project technologies will be developed that can facilitate human interaction in the context of instrumented meeting rooms, which includes remote participant support and the possibility to browse through past meetings. The project collects data on

  4. 78 FR 5184 - Subcommittee Meetings

    Science.gov (United States)

    2013-01-24

    ... locations: HSVR and HSQR Hyatt Regency Hotel Bethesda, One Metro Center, Bethesda, MD 20814 HCRT and HITR Hilton Washington DC/Rockville Hotel & Executive Meeting Center, 1750 Rockville Pike, Rockville, MD 20852... for dates of meetings: 1. Health System and Value Research (HSVR) Date: February 13, 2013 (Open from...

  5. Socialization at the morning meeting

    DEFF Research Database (Denmark)

    Rimestad, L.; Gravengaard, Gitte

    2016-01-01

    In this ethnographic study we examine how journalism interns present ideas at morning meetings in the professional environment of a media organization. We analyse not only the idea presentation at the meeting itself, but also how editors treat the idea presentation, and how the interns perceive...

  6. Faculty Meetings: Hidden Conversational Dynamics

    Science.gov (United States)

    Bowman, Richard F.

    2015-01-01

    In the everydayness of faculty meetings, collegial conversations mirror distinctive dynamics and practices, which either enhance or undercut organizational effectiveness. A cluster of conversational practices affect how colleagues connect, engage, interact, and influence others during faculty meetings in diverse educational settings. The…

  7. Joint IGCP 499/SDS Meeting

    Institute of Scientific and Technical Information of China (English)

    Peter K(o)nigshof; Eberhard Schindler; Volker Wildez; Jurga Lazauskiene; M. Namik Yal(c)in

    2006-01-01

    @@ A major event of IGCP 499 in 2005 took place in Southern Siberia. In the tradition of successful joint meetings and field trips of Devonian IGCP projects and the international Subcommission on Devonian Stratigraphy (SDS), a very successful meeting was held at the Institute of Petroleum Geology,United Institute of Geology and Mineralogy of the Russian Academy of Sciences, Siberian Branch in Novosibirsk.

  8. Melanoma genetics

    DEFF Research Database (Denmark)

    Read, Jazlyn; Wadt, Karin A W; Hayward, Nicholas K

    2016-01-01

    Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence...... of heritable melanoma risk genes is an important component of disease occurrence. Susceptibility for some families is due to mutation in one of the known high penetrance melanoma predisposition genes: CDKN2A, CDK4, BAP1, POT1, ACD, TERF2IP and TERT. However, despite such mutations being implicated...... in a combined total of approximately 50% of familial melanoma cases, the underlying genetic basis is unexplained for the remainder of high-density melanoma families. Aside from the possibility of extremely rare mutations in a few additional high penetrance genes yet to be discovered, this suggests a likely...

  9. Genetic Testing for ALS

    Science.gov (United States)

    ... Involved Donate Familial Amyotrophic Lateral Sclerosis (FALS) and Genetic Testing By Deborah Hartzfeld, MS, CGC, Certified Genetic Counselor ... in your area, please visit www.nsgc.org . Genetic Testing Genetic testing can help determine the cause of ...

  10. Genetic Science Learning Center

    Science.gov (United States)

    ... Mouse Party on Learn.Genetics.utah.edu Students doing the Tree of Genetic Traits activity Learn.Genetics is one of the most widely used science education websites in the world The Community Genetics ...

  11. 76 FR 18227 - Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee; Notice of...

    Science.gov (United States)

    2011-04-01

    ... HUMAN SERVICES Food and Drug Administration Molecular and Clinical Genetics Panel of the Medical Devices... Molecular and Clinical Genetics Panel (the panel) of the Medical Devices Advisory Committee that published... meeting of the Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee, and the...

  12. 28 CFR 16.202 - Open meetings.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Open meetings. 16.202 Section 16.202... Observation of Parole Commission Meetings § 16.202 Open meetings. (a) Every portion of every meeting of the... electronic device any portion of meetings which are open to the public. (c) The Commission shall...

  13. 37 CFR 251.11 - Open meetings.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Open meetings. 251.11 Section... Copyright Arbitration Royalty Panel Meetings § 251.11 Open meetings. (a) All meetings of a Copyright Arbitration Royalty Panel shall be open to the public, with the exception of meetings that are listed in §...

  14. 16 CFR 4.15 - Commission meetings.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Commission meetings. 4.15 Section 4.15... RULES § 4.15 Commission meetings. (a) In general. (1) Meetings of the Commission, as defined in 5 U.S.C... announcements of meetings. For each meeting, the Commission shall announce: (i) The time, place and...

  15. 75 FR 13296 - Sunshine Act Meetings

    Science.gov (United States)

    2010-03-19

    ... BOARD MEETING Sunshine Act Meetings TIME AND DATE: March 29, 2010; 9:00 a.m.-1 :30 p.m. PLACE: 901 N... Minutes of the December 14, 2009, Meeting of the Board of Directors Resolution Honoring Gary Bryner... Advisory Council Membership and Attendance at Meetings Status of Upcoming Meetings Status of...

  16. 18 CFR 375.203 - Open meetings.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Open meetings. 375.203... § 375.203 Open meetings. (a) General rule. Except as provided in § 375.206, meetings of the Commission will be open meetings. (b) Public participation in open meetings. (1) Members of the public are...

  17. 12 CFR 604.415 - Open meetings.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Open meetings. 604.415 Section 604.415 Banks and Banking FARM CREDIT ADMINISTRATION ADMINISTRATIVE PROVISIONS FARM CREDIT ADMINISTRATION BOARD MEETINGS § 604.415 Open meetings. Every meeting and portion of a meeting of the Board shall be open...

  18. 76 FR 23537 - Resource Advisory Committee Meeting

    Science.gov (United States)

    2011-04-27

    ... Resource Advisory Committee Meeting AGENCY: Forest Service, USDA. ACTION: Notice of Public Meeting, Sabine..., Sabine National Forest Resource Advisory Committee (RAC) meeting will meet as indicated below. DATES: The Sabine National Forest RAC meeting will be held on Thursday, May 5, 2011. ADDRESSES: The Sabine...

  19. E-Infrastructure Concertation Meeting

    CERN Multimedia

    Katarina Anthony

    2010-01-01

    The 8th e-Infrastructure Concertation Meeting was held in the Globe from 4 to 5 November to discuss the development of Europe’s distributed computing and storage resources.   Project leaders attend the E-Concertation Meeting at the Globe on 5 November 2010. © Corentin Chevalier E-Infrastructures have become an indispensable tool for scientific research, linking researchers to virtually unlimited e-resources like the grid. The recent e-Infrastructure Concertation Meeting brought together e-Science project leaders to discuss the development of this tool in the European context. The meeting was part of an ongoing initiative to develop a world-class e-infrastructure resource that would establish European leadership in e-Science. The e-Infrastructure Concertation Meeting was organised by the Commission Services (EC) with the support of e-ScienceTalk. “The Concertation meeting at CERN has been a great opportunity for e-ScienceTalk to meet many of the 38 new proje...

  20. CFCC working group meeting: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The theme of the meeting was ``A Path to Commercialization`` and discussion was devoted to addressing the nearest-term products and the time frame for implementation. The objectives of the meeting were to identify the barriers to commercialization, methods to overcome these barriers, and the actions required to achieve success. The meeting was planned to bring together government agencies and industry customers and, suppliers to discuss and conclude where the CFCC Program is today, where it is going, and how they plan to get there. It was also planned to join component developers with end users who can describe systems needs and projected schedules for introducing CFCC components in industrial applications.