7 CFR 251.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 251.1 Section 251.1... AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION THE EMERGENCY FOOD ASSISTANCE PROGRAM § 251.1 General purpose and scope. This part announces the policies and prescribes the regulations necessary to...

7 CFR 1485.10 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false General purpose and scope. 1485.10 Section 1485.10... FOREIGN MARKETS FOR AGRICULTURAL COMMODITIES Market Access Program § 1485.10 General purpose and scope. (a.../Market Access Program (EIP/MAP). It also establishes the general terms and conditions applicable to MAP...

7 CFR 215.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 215.1 Section 215.1... AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL MILK PROGRAM FOR CHILDREN § 215.1 General purpose and scope. This part announces the policies and prescribes the general regulations with respect to the Special Milk...

7 CFR 226.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 226.1 Section 226.1 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM General § 226.1 General purpose and...

7 CFR 1728.10 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false General purpose and scope. 1728.10 Section 1728.10 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC STANDARDS AND SPECIFICATIONS FOR MATERIALS AND CONSTRUCTION § 1728.10 General purpose and...

General purpose code for Monte Carlo simulations

International Nuclear Information System (INIS)

Wilcke, W.W.

1983-01-01

A general-purpose computer called MONTHY has been written to perform Monte Carlo simulations of physical systems. To achieve a high degree of flexibility the code is organized like a general purpose computer, operating on a vector describing the time dependent state of the system under simulation. The instruction set of the computer is defined by the user and is therefore adaptable to the particular problem studied. The organization of MONTHY allows iterative and conditional execution of operations

7 CFR 245.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 245.1 Section 245.1 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... SCHOOLS § 245.1 General purpose and scope. (a) This part established the responsibilities of State...

7 CFR 220.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 220.1 Section 220.1 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SCHOOL BREAKFAST PROGRAM § 220.1 General purpose and scope. This part...

7 CFR 235.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 235.1 Section 235.1 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS STATE ADMINISTRATIVE EXPENSE FUNDS § 235.1 General purpose and scope...

7 CFR 281.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 281.1 Section 281.1 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... RESERVATIONS § 281.1 General purpose and scope. (a) These regulations govern the operation of the Food Stamp...

Standalone General Purpose Data Logger Design and Implementation

African Journals Online (AJOL)

This paper describes the design of a general purpose data logger that is compatible with a variety of transducers, potentially permitting the measurement and recording of a wide range of phenomena. The recorded data can be retrieved to a PC via an RS-232 serial port. The standalone general purpose data logger ...

46 CFR 7.1 - General purpose of boundary lines.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false General purpose of boundary lines. 7.1 Section 7.1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES General § 7.1 General purpose of boundary lines. The lines in this part delineate the application of the...

General-Purpose Data Containers for Science and Engineering

International Nuclear Information System (INIS)

2015-01-01

In 2012 the SG38 international committee was formed to develop a modern structure to replace the ENDF-6 format for storing evaluated nuclear reaction data on a computer system. This committee divided the project into seven tasks. One of these tasks, the design of General-Purpose Data Containers (GPDCs), is described in this article. What type of data does SG38 need to store and why is the task called General-Purpose Data Containers? The most common types of data in an evaluated nuclear reaction database are representations of physical functions in tabulated forms. There is also a need to store 1-dimensional functions using truncated Legendre or polynomial (or others) expansions. The phrase General-Purpose implies that the containers are to be designed to store generic forms of tabulated data rather than one for each physical function. Also, where possible, it would be beneficial to design containers that can store data forms not currently used in evaluated nuclear database or at least be easily extended. In addition to containers for storing physical functions as tabulated data, other types of containers are needed. There exists a desire within SG38 to support the storage of documentation at various levels within an evaluated file. Containers for storing non-functional data (e.g., a list of numbers) as well as units and labels for axes are also needed. Herein, containers for storing physical functions are called functional containers. One of the goals for the general-purpose data containers task is to design containers that will be useful to other scientific and engineering applications. To meet this goal, task members should think outside of the immediate needs of evaluated nuclear data to ensure that the containers are general- purpose rather than simply repackaged versions of existing containers. While the examples in this article may be specific to nuclear reaction data, it is hoped that the end product will be useful for other applications. To this end, some

General purpose programmable accelerator board

Science.gov (United States)

Robertson, Perry J.; Witzke, Edward L.

2001-01-01

A general purpose accelerator board and acceleration method comprising use of: one or more programmable logic devices; a plurality of memory blocks; bus interface for communicating data between the memory blocks and devices external to the board; and dynamic programming capabilities for providing logic to the programmable logic device to be executed on data in the memory blocks.

19 CFR 191.10 - Certificate of delivery.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Certificate of delivery. 191.10 Section 191.10... TREASURY (CONTINUED) DRAWBACK General Provisions § 191.10 Certificate of delivery. (a) Purpose; when... other party a certificate of delivery, certified by the importer or other party through whose possession...

A general purpose code for Monte Carlo simulations

International Nuclear Information System (INIS)

Wilcke, W.W.; Rochester Univ., NY

1984-01-01

A general-purpose computer code MONTHY has been written to perform Monte Carlo simulations of physical systems. To achieve a high degree of flexibility the code is organized like a general purpose computer, operating on a vector describing the time dependent state of the system under simulation. The instruction set of the 'computer' is defined by the user and is therefore adaptable to the particular problem studied. The organization of MONTHY allows iterative and conditional execution of operations. (orig.)

Summary of JENDL-2 general purpose file

Energy Technology Data Exchange (ETDEWEB)

Nakagawa, Tsuneo [ed.

1984-06-15

The general purpose file of the second version of Japanese Evaluated Nuclear Data Library (JENDL-2) was released in December 1982. Recently, descriptive data were added to JENDL-2 and at the same time the first revision of numerical data was performed. JENDL-2 (Rev.1) consists of the data for 89 nuclides and about 211,000 records in the ENDF/B-IV format. In this report, full listings of presently added descriptive data are given to summarize the JENDL-2 general purpose file. The 2200-m/sec and 14-MeV cross sections, resonance integrals, Maxwellian and fission spectrum averaged cross sections are given in a table. Average cross sections were also calculated in suitable energy intervals.

Summary of JENDL-2 general purpose file

International Nuclear Information System (INIS)

Nakagawa, Tsuneo

1984-06-01

The general purpose file of the second version of Japanese Evaluated Nuclear Data Library (JENDL-2) was released in December 1982. Recently, descriptive data were added to JENDL-2 and at the same time the first revision of numerical data was performed. JENDL-2 (Rev1) consists of the data for 89 nuclides and about 211,000 records in the ENDF/B-IV format. In this report, full listings of presently added descriptive data are given to summarize the JENDL-2 general purpose file. The 2200-m/sec and 14-MeV cross sections, resonance integrals, Maxwellian and fission spectrum averaged cross sections are given in a table. Average cross sections were also calculated in suitable energy intervals. (author)

Smoking cessation delivery by general practitioners in Crete, Greece.

Science.gov (United States)

Girvalaki, Charis; Papadakis, Sophia; Vardavas, Constantine; Petridou, Eleni; Pipe, Andrew; Lionis, Christos

2018-06-01

Tobacco dependence treatment in clinical settings is of prime public health importance, especially in Greece, a country experiencing one of the highest rates of tobacco use in Europe. Our study aimed to examine the characteristics of tobacco users and document rates of tobacco treatment delivery in general practice settings in Crete, Greece. A cross-sectional sample of patients (n = 2, 261) was screened for current tobacco use in 25 general practices in Crete, Greece in 2015/16. Current tobacco users completed a survey following their clinic appointment that collected information on patient characteristics and rates at which the primary care physician delivered tobacco treatment using the evidence-based 4 A's (Ask, Advise, Assist, Arrange) model during their medical appointment and over the previous 12-month period. Multi-level modeling was used to analyze data and examine predictors of 4 A's delivery. Tobacco use prevalence was 38% among all patients screened. A total of 840 tobacco users completed the study survey [mean age 48.0 (SD 14.5) years, 57.6% male]. Approximately, half of the tobacco users reported their general practitioner 'asked' about their tobacco use and 'advised' them to quit smoking. Receiving 'assistance' with quitting (15.7%) and 'arranging' follow-up support (<3%) was infrequent. Patient education, presence of smoking-related illness, a positive screen for anxiety or depression and the type of medical appointment were associated with 4 A's delivery. Given the fundamental importance of addressing tobacco treatment, increasing the rates of 4 A's treatment in primary care settings in Greece is an important target for improving patient care.

7 CFR 227.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... management training of school foodservice personnel, and (c) the conduct of nutrition education activities in... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM General § 227.1 General purpose...

24 CFR 902.1 - Purpose and general description.

Science.gov (United States)

2010-04-01

... assessments. The Real Estate Assessment Center (REAC) is responsible for assessing and scoring the performance... uniform and objective protocols for the physical inspection of properties and the financial assessment of... URBAN DEVELOPMENT PUBLIC HOUSING ASSESSMENT SYSTEM General Provisions § 902.1 Purpose and general...

General-purpose RFQ design program

International Nuclear Information System (INIS)

Wadlinger, E.A.

1984-01-01

We have written a general-purpose, radio-frequency quadrupole (RFQ) design program that allows maximum flexibility in picking design algorithms. This program optimizes the RFQ on any combination of design parameters while simultaneously satisfying mutually compatible, physically required constraint equations. It can be very useful for deriving various scaling laws for RFQs. This program has a friendly user interface in addition to checking the consistency of the user-defined requirements and is written to minimize the effort needed to incorporate additional constraint equations. We describe the program and present some examples

A Small Acoustic Goniometer for General Purpose Research.

Science.gov (United States)

Pook, Michael L; Loo, Sin Ming

2016-04-29

Understanding acoustic events and monitoring their occurrence is a useful aspect of many research projects. In particular, acoustic goniometry allows researchers to determine the source of an event based solely on the sound it produces. The vast majority of acoustic goniometry research projects used custom hardware targeted to the specific application under test. Unfortunately, due to the wide range of sensing applications, a flexible general purpose hardware/firmware system does not exist for this purpose. This article focuses on the development of such a system which encourages the continued exploration of general purpose hardware/firmware and lowers barriers to research in projects requiring the use of acoustic goniometry. Simulations have been employed to verify system feasibility, and a complete hardware implementation of the acoustic goniometer has been designed and field tested. The results are reported, and suggested areas for improvement and further exploration are discussed.

Efficient probabilistic model checking on general purpose graphic processors

NARCIS (Netherlands)

Bosnacki, D.; Edelkamp, S.; Sulewski, D.; Pasareanu, C.S.

2009-01-01

We present algorithms for parallel probabilistic model checking on general purpose graphic processing units (GPGPUs). For this purpose we exploit the fact that some of the basic algorithms for probabilistic model checking rely on matrix vector multiplication. Since this kind of linear algebraic

General Purpose Crate (GPC) for control applications

International Nuclear Information System (INIS)

Singh, Kundan; Munda, Deepak K.; Jain, Mamta; Archunan, M.; Barua, P.; Ajith Kumar, B.P.

2011-01-01

A General Purpose Crate (GPC) capable of handling digital and analog Inputs/Outputs signals has been developed at Inter University Accelerator Centre (IUAC), New Delhi, for accelerator control system applications. The system includes back-plane bus with on board plugged-in single board computer with PC104 and Ethernet interface, running Linux operating system. The bus control logic is designed on the back-plane pcb itself, making the system more rugged. The various types of digital and analog input/output modules can be plugged into the back plane bus randomly with standard euro connectors, which provides highly reliable and dust free contacts. Maximum eight modules can be inserted into the crate. The total power consumption for various types of modules and back-plane controller is approximately 50 watts. The multi-output DC power supply from COSEL has been used in the crate. The general purpose crate is software compatible with the CAMAC crates used in the accelerator control system. (author)

Development of General Purpose Data Acquisition Shell (GPDAS)

International Nuclear Information System (INIS)

Chung, Y.; Kim, K.

1995-01-01

This note is intended as an abbreviated introduction to the concept and the structure of General Purpose Data Acquisitions Shell (GPDAS) and assumes the reader has a certain level of familiarity with programming in general. The structure of the following sections consists of brief explanations of the concepts and commands of GPDAS, followed by several examples. Some of these are tabulated in the appendices at the end of this note

Perbandingan Kemampuan Embedded Computer dengan General Purpose Computer untuk Pengolahan Citra

Directory of Open Access Journals (Sweden)

Herryawan Pujiharsono

2017-08-01

Full Text Available Perkembangan teknologi komputer membuat pengolahan citra saat ini banyak dikembangkan untuk dapat membantu manusia di berbagai bidang pekerjaan. Namun, tidak semua bidang pekerjaan dapat dikembangkan dengan pengolahan citra karena tidak mendukung penggunaan komputer sehingga mendorong pengembangan pengolahan citra dengan mikrokontroler atau mikroprosesor khusus. Perkembangan mikrokontroler dan mikroprosesor memungkinkan pengolahan citra saat ini dapat dikembangkan dengan embedded computer atau single board computer (SBC. Penelitian ini bertujuan untuk menguji kemampuan embedded computer dalam mengolah citra dan membandingkan hasilnya dengan komputer pada umumnya (general purpose computer. Pengujian dilakukan dengan mengukur waktu eksekusi dari empat operasi pengolahan citra yang diberikan pada sepuluh ukuran citra. Hasil yang diperoleh pada penelitian ini menunjukkan bahwa optimasi waktu eksekusi embedded computer lebih baik jika dibandingkan dengan general purpose computer dengan waktu eksekusi rata-rata embedded computer adalah 4-5 kali waktu eksekusi general purpose computer dan ukuran citra maksimal yang tidak membebani CPU terlalu besar untuk embedded computer adalah 256x256 piksel dan untuk general purpose computer adalah 400x300 piksel.

Medical Education and Health Care Delivery: A Call to Better Align Goals and Purposes.

Science.gov (United States)

Sklar, David P; Hemmer, Paul A; Durning, Steven J

2018-03-01

The transformation of the U.S. health care system is under way, driven by the needs of an aging population, rising health care spending, and the availability of health information. However, the speed and effectiveness of the transformation of health care delivery will depend, in large part, upon engagement of the health professions community and changes in clinicians' practice behaviors. Current efforts to influence practice behaviors emphasize changes in the health payment system with incentives to move from fee-for-service to alternative payment models.The authors describe the potential of medical education to augment payment incentives to make changes in clinical practice and the importance of aligning the purpose and goals of medical education with those of the health care delivery system. The authors discuss how curricular and assessment changes and faculty development can align medical education with the transformative trends in the health care delivery system. They also explain how the theory of situated cognition offers a shared conceptual framework that could help address the misalignment of education and clinical care. They provide examples of how quality improvement, health care innovation, population care management, and payment alignment could create bridges for joining health care delivery and medical education to meet the health care reform goals of a high-performing health care delivery system while controlling health care spending. Finally, the authors illustrate how current payment incentives such as bundled payments, value-based purchasing, and population-based payments can work synergistically with medical education to provide high-value care.

How General-Purpose can a GPU be?

Directory of Open Access Journals (Sweden)

Philip Machanick

2015-12-01

Full Text Available The use of graphics processing units (GPUs in general-purpose computation (GPGPU is a growing field. GPU instruction sets, while implementing a graphics pipeline, draw from a range of single instruction multiple datastream (SIMD architectures characteristic of the heyday of supercomputers. Yet only one of these SIMD instruction sets has been of application on a wide enough range of problems to survive the era when the full range of supercomputer design variants was being explored: vector instructions. This paper proposes a reconceptualization of the GPU as a multicore design with minimal exotic modes of parallelism so as to make GPGPU truly general.

The purpose of the general practice consultation from the patients perspective - theoretical aspects

DEFF Research Database (Denmark)

Thorsen, Hanne; Witt, Klaus; Malterud, Kirsti

2001-01-01

Consultation purposes, general practice, patients´expectations, patients satosfaction, patientcenteredness......Consultation purposes, general practice, patients´expectations, patients satosfaction, patientcenteredness...

Stoppage - Vat Return and Accounting Practice in Re-Delivery of a Delivery Subject to Stoppage

Directory of Open Access Journals (Sweden)

Ahmet Yanık

2016-12-01

Full Text Available Value Added Tax (VAT is calculated based on the goods and service delivery costs realized by the corporations. Unless this VAT is subject to stoppage, seller takes the VAT from the purchaser in delivery of goods or services and then the corporate pays this amount to the tax office or sets off through the VAT he paid for his service or goods procurement. However, in some cases, Ministry of Finance holds not those providing the delivery or service but those purchasing or procuring the goods or services responsible partly or fully for the tax calculated based on the delivery or service fee. The purpose of this paper is to reveal VAT stoppage, accounting entries with regards to the corporation accepting the delivery and re-delivering it, VAT set off and VAT return in the re-delivery of a delivery subject to stoppage pursuant to General Communiqué of VAT Serial No 117

General Purpose Multimedia Dataset - GarageBand 2008

DEFF Research Database (Denmark)

Meng, Anders

This document describes a general purpose multimedia data-set to be used in cross-media machine learning problems. In more detail we describe the genre taxonomy applied at http://www.garageband.com, from where the data-set was collected, and how the taxonomy have been fused into a more human...... understandable taxonomy. Finally, a description of various features extracted from both the audio and text are presented....

ENDF/B-4 General Purpose File 1974

International Nuclear Information System (INIS)

Schwerer, O.

1980-04-01

This document summarizes contents and documentation of the 1974 version of the General Purpose File of the ENDF/B Library maintained by the National Nuclear Data Center (NNDC) at the Brookhaven National Laboratory, USA. The Library contains numerical neutron reaction data for 90 isotopes or elements. The entire Library or selective retrievals from it can be obtained on magnetic tape from the IAEA Nuclear Data Section. (author)

Lipseys Quest for the Micro-foundations of GPT-the General Purpose Engine

NARCIS (Netherlands)

Van der Kooij, B.J.G.

2016-01-01

The construct of the General Purpose Technology misses its micro-foundation (as observed by Richard Lipsey). We present a possible solution in the General Purpose Engines. These are the basic innovations and the clusters of contributing and derived innovation, that appear in a Schumpeterian 'cluster

General Purpose Heat Source Simulator

Science.gov (United States)

Emrich, Bill

2008-01-01

The General Purpose Heat Source (GPHS) simulator project is designed to replicate through the use of electrical heaters, the form, fit, and function of actual GPHS modules which generate heat through the radioactive decay of Pu238. The use of electrically heated modules rather than modules containing Pu238 facilitates the testing of spacecraft subsystems and systems without sacrificing the quantity and quality of the test data gathered. Previous GPHS activities are centered around developing robust heater designs with sizes and weights that closely matched those of actual Pu238 fueled GPHS blocks. These efforts were successful, although their maximum temperature capabilities were limited to around 850 C. New designs are being pursued which also replicate the sizes and weights of actual Pu238 fueled GPHS blocks but will allow operation up to 1100 C.

The delivery of general paediatric surgery in Ireland: a survey of higher surgical trainees.

LENUS (Irish Health Repository)

Boyle, E

2012-12-01

The delivery of general paediatric surgery is changing in Ireland. Fewer paediatric surgical procedures are being performed by newly appointed consultant general surgeons, resulting in increased referrals to the specialist paediatric surgeons of uncomplicated general paediatric surgical problems. We surveyed current higher surgical trainees about their views on provision of paediatric surgical services.

Geographical parthenogenesis: General purpose genotypes and frozen niche variation

DEFF Research Database (Denmark)

Vrijenhoek, Robert C.; Parker, Dave

2009-01-01

hypotheses concerning the evolution of niche breadth in asexual species - the "general-purpose genotype" (GPG) and "frozen niche-variation" (FNV) models. The two models are often portrayed as mutually exclusive, respectively viewing clonal lineages as generalists versus specialists. Nonetheless...

Speed Control of General Purpose Engine with Electronic Governor

Science.gov (United States)

Sawut, Umerujan; Tohti, Gheyret; Takigawa, Buso; Tsuji, Teruo

This paper presents a general purpose engine speed control system with an electronic governor in order to improve the current system with a mechanical governor which shows unstable characteristics by change of mecanical friction or A/F ratio (Air/Fuel ratio). For the control system above, there are problems that the feedback signal is only a crank angle because of cost and the controlled object is a general purpose engine which is strongly nonlinear. In order to overcome these problems, the system model is shown for the dynamic estimation of the amount of air flow and the robust controller is designed. That is, the proposed system includes the robust sliding-mode controller by the feedback signal of only a crank angle where Genetic Algorithm is applied for the controller design. The simulation and the experiments by MATLAB/Simulink are performed to show the effectiveness of our proposal.

Generalized Fluid System Simulation Program (GFSSP) Version 6 - General Purpose Thermo-Fluid Network Analysis Software

Science.gov (United States)

Majumdar, Alok; Leclair, Andre; Moore, Ric; Schallhorn, Paul

2011-01-01

GFSSP stands for Generalized Fluid System Simulation Program. It is a general-purpose computer program to compute pressure, temperature and flow distribution in a flow network. GFSSP calculates pressure, temperature, and concentrations at nodes and calculates flow rates through branches. It was primarily developed to analyze Internal Flow Analysis of a Turbopump Transient Flow Analysis of a Propulsion System. GFSSP development started in 1994 with an objective to provide a generalized and easy to use flow analysis tool for thermo-fluid systems.

Sense and purpose of bilateral agreements - a general survey

International Nuclear Information System (INIS)

Buehler, O.

1999-01-01

Switzerland has concluded with its neighbouring States several bilateral agreements on nuclear information and on mutual help in case of catastrophes. The following general survey explains the sense and purpose of these agreements which complement the IAEA-Conventions referring to the same matters. (orig.) [de

Weldability of general purpose heat source new-process iridium

International Nuclear Information System (INIS)

Kanne, W.R.

1987-01-01

Weldability tests on General Purpose Heat Source (GPHS) iridium capsules showed that a new iridium fabrication process reduced susceptibility to underbead cracking. Seventeen capsules were welded (a total of 255 welds) in four categories and the number of cracks in each weld was measured

Report of the general purpose detector group

International Nuclear Information System (INIS)

Barbaro-Galtieri, A.; Bartel, W.; Bulos, F.; Cool, R.; Hanson, G.; Koetz, U.; Kottahaus, R.; Loken, S.; Luke, D.; Rothenberg, A.

1975-01-01

A general purpose detector for PEP is described. The main components of this detector are a l meter radius, 15 kilogauss superconducting solenoidal magnet with drift chambers to detect and measure the momentum of charged particles, a liquid argon neutral detector and hadron calorimeter, and a system of Cherenkov and time-of-flight counters for identification of charged hadrons. A major consideration in the design of this detector was that it be flexible: the magnet coil and drift chambers form a core around which various apparatus for specialized detection can be placed

Discrete-Event Execution Alternatives on General Purpose Graphical Processing Units

International Nuclear Information System (INIS)

Perumalla, Kalyan S.

2006-01-01

Graphics cards, traditionally designed as accelerators for computer graphics, have evolved to support more general-purpose computation. General Purpose Graphical Processing Units (GPGPUs) are now being used as highly efficient, cost-effective platforms for executing certain simulation applications. While most of these applications belong to the category of time-stepped simulations, little is known about the applicability of GPGPUs to discrete event simulation (DES). Here, we identify some of the issues and challenges that the GPGPU stream-based interface raises for DES, and present some possible approaches to moving DES to GPGPUs. Initial performance results on simulation of a diffusion process show that DES-style execution on GPGPU runs faster than DES on CPU and also significantly faster than time-stepped simulations on either CPU or GPGPU.

General-Purpose Software For Computer Graphics

Science.gov (United States)

Rogers, Joseph E.

1992-01-01

NASA Device Independent Graphics Library (NASADIG) is general-purpose computer-graphics package for computer-based engineering and management applications which gives opportunity to translate data into effective graphical displays for presentation. Features include two- and three-dimensional plotting, spline and polynomial interpolation, control of blanking of areas, multiple log and/or linear axes, control of legends and text, control of thicknesses of curves, and multiple text fonts. Included are subroutines for definition of areas and axes of plots; setup and display of text; blanking of areas; setup of style, interpolation, and plotting of lines; control of patterns and of shading of colors; control of legends, blocks of text, and characters; initialization of devices; and setting of mixed alphabets. Written in FORTRAN 77.

General-purpose heat source development. Phase I: design requirements

International Nuclear Information System (INIS)

Snow, E.C.; Zocher, R.W.

1978-09-01

Studies have been performed to determine the necessary design requirements for a 238 PuO 2 General-Purpose Heat Source (GPHS). Systems and missions applications, as well as accident conditions, were considered. The results of these studies, along with the recommended GPHS design requirements, are given in this report

Design of low-cost general purpose microcontroller based neuromuscular stimulator.

Science.gov (United States)

Koçer, S; Rahmi Canal, M; Güler, I

2000-04-01

In this study, a general purpose, low-cost, programmable, portable and high performance stimulator is designed and implemented. For this purpose, a microcontroller is used in the design of the stimulator. The duty cycle and amplitude of the designed system can be controlled using a keyboard. The performance test of the system has shown that the results are reliable. The overall system can be used as the neuromuscular stimulator under safe conditions.

Low Overhead Real-Time Computing With General Purpose Operating Systems

National Research Council Canada - National Science Library

Raymond, Michael

2004-01-01

.... In larger systems and more recently, general-purpose operating systems such as SGI IRIX and Linux are used for new projects because they already have multiprocessor and device driver support as well a large user base...

Incremental and developmental perspectives for general-purpose learning systems

Directory of Open Access Journals (Sweden)

Fernando Martínez-Plumed

2017-02-01

Full Text Available The stupefying success of Articial Intelligence (AI for specic problems, from recommender systems to self-driving cars, has not yet been matched with a similar progress in general AI systems, coping with a variety of (dierent problems. This dissertation deals with the long-standing problem of creating more general AI systems, through the analysis of their development and the evaluation of their cognitive abilities. It presents a declarative general-purpose learning system and a developmental and lifelong approach for knowledge acquisition, consolidation and forgetting. It also analyses the use of the use of more ability-oriented evaluation techniques for AI evaluation and provides further insight for the understanding of the concepts of development and incremental learning in AI systems.

21 CFR 862.2050 - General purpose laboratory equipment labeled or promoted for a specific medical use.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false General purpose laboratory equipment labeled or... TOXICOLOGY DEVICES Clinical Laboratory Instruments § 862.2050 General purpose laboratory equipment labeled or promoted for a specific medical use. (a) Identification. General purpose laboratory equipment labeled or...

General purpose modeling languages for configuration

DEFF Research Database (Denmark)

Queva, Matthieu Stéphane Benoit

In the later years, there has been an important need for companies to reduce their costs while proposing highly customized products. Indeed, today's customers demand products with lower prices, higher quality and faster delivery, but they also want products customized to match their unique needs....

On the System and Engineering Design of the General Purpose ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 5. On the System and Engineering Design of the General Purpose Electronic Digital Computer at TIFR. Rangaswamy Narasimhan. Classics Volume 13 Issue 5 May 2008 pp 490-501 ...

New Generation General Purpose Computer (GPC) compact IBM unit

Science.gov (United States)

1991-01-01

New Generation General Purpose Computer (GPC) compact IBM unit replaces a two-unit earlier generation computer. The new IBM unit is documented in table top views alone (S91-26867, S91-26868), with the onboard equipment it supports including the flight deck CRT screen and keypad (S91-26866), and next to the two earlier versions it replaces (S91-26869).

A general-purpose development environment for intelligent computer-aided training systems

Science.gov (United States)

Savely, Robert T.

1990-01-01

Space station training will be a major task, requiring the creation of large numbers of simulation-based training systems for crew, flight controllers, and ground-based support personnel. Given the long duration of space station missions and the large number of activities supported by the space station, the extension of space shuttle training methods to space station training may prove to be impractical. The application of artificial intelligence technology to simulation training can provide the ability to deliver individualized training to large numbers of personnel in a distributed workstation environment. The principal objective of this project is the creation of a software development environment which can be used to build intelligent training systems for procedural tasks associated with the operation of the space station. Current NASA Johnson Space Center projects and joint projects with other NASA operational centers will result in specific training systems for existing space shuttle crew, ground support personnel, and flight controller tasks. Concurrently with the creation of these systems, a general-purpose development environment for intelligent computer-aided training systems will be built. Such an environment would permit the rapid production, delivery, and evolution of training systems for space station crew, flight controllers, and other support personnel. The widespread use of such systems will serve to preserve task and training expertise, support the training of many personnel in a distributed manner, and ensure the uniformity and verifiability of training experiences. As a result, significant reductions in training costs can be realized while safety and the probability of mission success can be enhanced.

Survey of advanced general-purpose software for robot manipulators

International Nuclear Information System (INIS)

Latombe, J.C.

1983-01-01

Computer-controlled sensor-based robots will more and more common in industry. This paper attempts to survey the main trends of the development of advanced general-purpose software for robot manipulators. It is intended to make clear that robots are not only mechanical devices. They are truly programmable machines, and their programming, which occurs in an imperfectly modelled world,is somewhat different from conventional computer programming. (orig.)

The ATLAS Trigger Algorithms for General Purpose Graphics Processor Units

CERN Document Server

Tavares Delgado, Ademar; The ATLAS collaboration

2016-01-01

The ATLAS Trigger Algorithms for General Purpose Graphics Processor Units Type: Talk Abstract: We present the ATLAS Trigger algorithms developed to exploit General­ Purpose Graphics Processor Units. ATLAS is a particle physics experiment located on the LHC collider at CERN. The ATLAS Trigger system has two levels, hardware-­based Level 1 and the High Level Trigger implemented in software running on a farm of commodity CPU. Performing the trigger event selection within the available farm resources presents a significant challenge that will increase future LHC upgrades. are being evaluated as a potential solution for trigger algorithms acceleration. Key factors determining the potential benefit of this new technology are the relative execution speedup, the number of GPUs required and the relative financial cost of the selected GPU. We have developed a trigger demonstrator which includes algorithms for reconstructing tracks in the Inner Detector and Muon Spectrometer and clusters of energy deposited in the Cal...

Using the general-purpose reactivity indicator: challenging examples.

Science.gov (United States)

Anderson, James S M; Melin, Junia; Ayers, Paul W

2016-03-01

We elucidate the regioselectivity of nucleophilic attack on substituted benzenesulfonates, quinolines, and pyridines using a general-purpose reactivity indicator (GPRI) for electrophiles. We observe that the GPRI is most accurate when the incoming nucleophile resembles a point charge. We further observe that the GPRI often chooses reactive "dead ends" as the most reactive sites as well as sterically hindered reactive sites. This means that care must be taken to remove sites that are inherently unreactive. Generally, among sites where reactions actually occur, the GPRI identifies the sites in the molecule that lead to the kinetically favored product(s). Furthermore, the GPRI can discern which sites react with hard reagents and which sites react with soft reagents. Because it is currently impossible to use the mathematical framework of conceptual DFT to identify sterically inaccessible sites and reactive dead ends, the GPRI is primarily useful as an interpretative, not a predictive, tool.

SRAC95; general purpose neutronics code system

International Nuclear Information System (INIS)

Okumura, Keisuke; Tsuchihashi, Keichiro; Kaneko, Kunio.

1996-03-01

SRAC is a general purpose neutronics code system applicable to core analyses of various types of reactors. Since the publication of JAERI-1302 for the revised SRAC in 1986, a number of additions and modifications have been made for nuclear data libraries and programs. Thus, the new version SRAC95 has been completed. The system consists of six kinds of nuclear data libraries(ENDF/B-IV, -V, -VI, JENDL-2, -3.1, -3.2), five modular codes integrated into SRAC95; collision probability calculation module (PIJ) for 16 types of lattice geometries, Sn transport calculation modules(ANISN, TWOTRAN), diffusion calculation modules(TUD, CITATION) and two optional codes for fuel assembly and core burn-up calculations(newly developed ASMBURN, revised COREBN). In this version, many new functions and data are implemented to support nuclear design studies of advanced reactors, especially for burn-up calculations. SRAC95 is available not only on conventional IBM-compatible computers but also on scalar or vector computers with the UNIX operating system. This report is the SRAC95 users manual which contains general description, contents of revisions, input data requirements, detail information on usage, sample input data and list of available libraries. (author)

SRAC95; general purpose neutronics code system

Energy Technology Data Exchange (ETDEWEB)

Okumura, Keisuke; Tsuchihashi, Keichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Kaneko, Kunio

1996-03-01

SRAC is a general purpose neutronics code system applicable to core analyses of various types of reactors. Since the publication of JAERI-1302 for the revised SRAC in 1986, a number of additions and modifications have been made for nuclear data libraries and programs. Thus, the new version SRAC95 has been completed. The system consists of six kinds of nuclear data libraries(ENDF/B-IV, -V, -VI, JENDL-2, -3.1, -3.2), five modular codes integrated into SRAC95; collision probability calculation module (PIJ) for 16 types of lattice geometries, Sn transport calculation modules(ANISN, TWOTRAN), diffusion calculation modules(TUD, CITATION) and two optional codes for fuel assembly and core burn-up calculations(newly developed ASMBURN, revised COREBN). In this version, many new functions and data are implemented to support nuclear design studies of advanced reactors, especially for burn-up calculations. SRAC95 is available not only on conventional IBM-compatible computers but also on scalar or vector computers with the UNIX operating system. This report is the SRAC95 users manual which contains general description, contents of revisions, input data requirements, detail information on usage, sample input data and list of available libraries. (author).

78 FR 65300 - Notice of Availability (NOA) for General Purpose Warehouse and Information Technology Center...

Science.gov (United States)

2013-10-31

... (NOA) for General Purpose Warehouse and Information Technology Center Construction (GPW/IT)--Tracy Site... proposed action to construct a General Purpose Warehouse and Information Technology Center at Defense..., Suite 02G09, Alexandria, VA 22350- 3100. FOR FURTHER INFORMATION CONTACT: Ann Engelberger at (703) 767...

Optimization of GATE and PHITS Monte Carlo code parameters for uniform scanning proton beam based on simulation with FLUKA general-purpose code

Energy Technology Data Exchange (ETDEWEB)

Kurosu, Keita [Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Takashina, Masaaki; Koizumi, Masahiko [Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States); Moskvin, Vadim P., E-mail: vadim.p.moskvin@gmail.com [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States)

2014-10-01

Although three general-purpose Monte Carlo (MC) simulation tools: Geant4, FLUKA and PHITS have been used extensively, differences in calculation results have been reported. The major causes are the implementation of the physical model, preset value of the ionization potential or definition of the maximum step size. In order to achieve artifact free MC simulation, an optimized parameters list for each simulation system is required. Several authors have already proposed the optimized lists, but those studies were performed with a simple system such as only a water phantom. Since particle beams have a transport, interaction and electromagnetic processes during beam delivery, establishment of an optimized parameters-list for whole beam delivery system is therefore of major importance. The purpose of this study was to determine the optimized parameters list for GATE and PHITS using proton treatment nozzle computational model. The simulation was performed with the broad scanning proton beam. The influences of the customizing parameters on the percentage depth dose (PDD) profile and the proton range were investigated by comparison with the result of FLUKA, and then the optimal parameters were determined. The PDD profile and the proton range obtained from our optimized parameters list showed different characteristics from the results obtained with simple system. This led to the conclusion that the physical model, particle transport mechanics and different geometry-based descriptions need accurate customization in planning computational experiments for artifact-free MC simulation.

Optimization of GATE and PHITS Monte Carlo code parameters for uniform scanning proton beam based on simulation with FLUKA general-purpose code

International Nuclear Information System (INIS)

Kurosu, Keita; Takashina, Masaaki; Koizumi, Masahiko; Das, Indra J.; Moskvin, Vadim P.

2014-01-01

Although three general-purpose Monte Carlo (MC) simulation tools: Geant4, FLUKA and PHITS have been used extensively, differences in calculation results have been reported. The major causes are the implementation of the physical model, preset value of the ionization potential or definition of the maximum step size. In order to achieve artifact free MC simulation, an optimized parameters list for each simulation system is required. Several authors have already proposed the optimized lists, but those studies were performed with a simple system such as only a water phantom. Since particle beams have a transport, interaction and electromagnetic processes during beam delivery, establishment of an optimized parameters-list for whole beam delivery system is therefore of major importance. The purpose of this study was to determine the optimized parameters list for GATE and PHITS using proton treatment nozzle computational model. The simulation was performed with the broad scanning proton beam. The influences of the customizing parameters on the percentage depth dose (PDD) profile and the proton range were investigated by comparison with the result of FLUKA, and then the optimal parameters were determined. The PDD profile and the proton range obtained from our optimized parameters list showed different characteristics from the results obtained with simple system. This led to the conclusion that the physical model, particle transport mechanics and different geometry-based descriptions need accurate customization in planning computational experiments for artifact-free MC simulation

A randomised comparison between an inexpensive, general-purpose headlight and a purpose-built surgical headlight on users' visual acuity and colour vision.

Science.gov (United States)

Street, I; Sayles, M; Nistor, M; McRae, A R

2014-02-01

To determine if there are any differences in near visual acuity and colour vision between an inexpensive general-purpose light emitting diode (LED) headlight and a purpose-built surgical LED headlight. A prospective study was conducted sequentially comparing near visual acuity and colour vision, the headlights being tested in random order, in a testing room with a constant minimal amount of background light. The participants were NHS employee volunteers, with self-declared normal (or corrected) vision, working in occupations requiring full literacy. For visual acuity, outcome was measured by recording the smallest font legible when using each headlight when the subject read a near visual acuity test card. For colour vision, the outcome was passing or failing the Ishihara test. There was no statistically significant difference between the general-purpose and the purpose-built headlights in users' near visual acuity or colour vision.

Aptamer-Gated Nanoparticles for Smart Drug Delivery

Directory of Open Access Journals (Sweden)

Huseyin Avni Oktem

2011-08-01

Full Text Available Aptamers are functional nucleic acid sequences which can bind specific targets. An artificial combinatorial methodology can identify aptamer sequences for any target molecule, from ions to whole cells. Drug delivery systems seek to increase efficacy and reduce side-effects by concentrating the therapeutic agents at specific disease sites in the body. This is generally achieved by specific targeting of inactivated drug molecules. Aptamers which can bind to various cancer cell types selectively and with high affinity have been exploited in a variety of drug delivery systems for therapeutic purposes. Recent progress in selection of cell-specific aptamers has provided new opportunities in targeted drug delivery. Especially functionalization of nanoparticles with such aptamers has drawn major attention in the biosensor and biomedical areas. Moreover, nucleic acids are recognized as an attractive building materials in nanomachines because of their unique molecular recognition properties and structural features. A active controlled delivery of drugs once targeted to a disease site is a major research challenge. Stimuli-responsive gating is one way of achieving controlled release of nanoparticle cargoes. Recent reports incorporate the structural properties of aptamers in controlled release systems of drug delivering nanoparticles. In this review, the strategies for using functional nucleic acids in creating smart drug delivery devices will be explained. The main focus will be on aptamer-incorporated nanoparticle systems for drug delivery purposes in order to assess the future potential of aptamers in the therapeutic area. Special emphasis will be given to the very recent progress in controlled drug release based on molecular gating achieved with aptamers.

General-purpose parallel simulator for quantum computing

International Nuclear Information System (INIS)

Niwa, Jumpei; Matsumoto, Keiji; Imai, Hiroshi

2002-01-01

With current technologies, it seems to be very difficult to implement quantum computers with many qubits. It is therefore of importance to simulate quantum algorithms and circuits on the existing computers. However, for a large-size problem, the simulation often requires more computational power than is available from sequential processing. Therefore, simulation methods for parallel processors are required. We have developed a general-purpose simulator for quantum algorithms/circuits on the parallel computer (Sun Enterprise4500). It can simulate algorithms/circuits with up to 30 qubits. In order to test efficiency of our proposed methods, we have simulated Shor's factorization algorithm and Grover's database search, and we have analyzed robustness of the corresponding quantum circuits in the presence of both decoherence and operational errors. The corresponding results, statistics, and analyses are presented in this paper

24 CFR 990.310 - Purpose-General policy on financial management, monitoring and reporting.

Science.gov (United States)

2010-04-01

... Management Systems, Monitoring, and Reporting § 990.310 Purpose—General policy on financial management, monitoring and reporting. All PHA financial management systems, reporting, and monitoring of program... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Purpose-General policy on financial...

The architecture of Newton, a general-purpose dynamics simulator

Science.gov (United States)

Cremer, James F.; Stewart, A. James

1989-01-01

The architecture for Newton, a general-purpose system for simulating the dynamics of complex physical objects, is described. The system automatically formulates and analyzes equations of motion, and performs automatic modification of this system equations when necessitated by changes in kinematic relationships between objects. Impact and temporary contact are handled, although only using simple models. User-directed influence of simulations is achieved using Newton's module, which can be used to experiment with the control of many-degree-of-freedom articulated objects.

Foam: A general purpose Monte Carlo cellular algorithm

International Nuclear Information System (INIS)

Jadach, S.

2003-01-01

A general-purpose, self-adapting Monte Carlo (MC) algorithm implemented in the program Foam is described. The high efficiency of the MC, that is small maximum weight or variance of the MC weight is achieved by means of dividing the integration domain into small cells. The cells can be n-dimensional simplices, hyperrectangles cells. The next cell to be divided and the position/direction of the division hyperplane is chosen by the algorithm which optimizes the ratio of the maximum weight to the average weight or (optionally) the total variance. The algorithm is able to deal, in principle, with an arbitrary pattern of the singularities in the distribution

Using general-purpose compression algorithms for music analysis

DEFF Research Database (Denmark)

Louboutin, Corentin; Meredith, David

2016-01-01

General-purpose compression algorithms encode files as dictionaries of substrings with the positions of these strings’ occurrences. We hypothesized that such algorithms could be used for pattern discovery in music. We compared LZ77, LZ78, Burrows–Wheeler and COSIATEC on classifying folk song...... in the input data, COSIATEC outperformed LZ77 with a mean F1 score of 0.123, compared with 0.053 for LZ77. However, when the music was processed a voice at a time, the F1 score for LZ77 more than doubled to 0.124. We also discovered a significant correlation between compression factor and F1 score for all...

Design method of general-purpose driving circuit for CCD based on CPLD

International Nuclear Information System (INIS)

Zhang Yong; Tang Benqi; Xiao Zhigang; Wang Zujun; Huang Shaoyan

2005-01-01

It is very important for studying the radiation damage effects and mechanism systematically about CCD to develop a general-purpose test platform. The paper discusses the design method of general-purpose driving circuit for CCD based on CPLD and the realization approach. A main controller has being designed to read the data file from the outer memory, setup the correlative parameter registers and produce the driving pulses according with parameter request strictly, which is based on MAX7000S by using MAX-PLUS II software. The basic driving circuit module has being finished based on this method. The output waveform of the module is the same figure as the simulation waveform. The result indicates that the design method is feasible. (authors)

Application of a general purpose finite element program system in pressure vessel technology

International Nuclear Information System (INIS)

Aamodt, B.; Sandsmark, N.; Medonos, S.

1977-01-01

Main advantages of using general purpose finite element program systems in structural analysis are summarized. Several illustrative applications of the program system SESAM-69 to pressure vessel problems are described. The first example is a dynamic analysis of the motor housing of the internal main circulation pump of a BWR nuclear reactor. The next example is a transient heat conduction and stress analysis of deflector of feeding nozzle of PWR nuclear reactor. Then, numerical calculations of stress intensity factors and fatigue crack growth of semi-elliptical surface cracks are discussed. And finally, an elasto-plastic analysis of a thick plate with edge-cracks is considered. It is concluded that due to the fact that general purpose finite element program systems are general and user-orientated, they will gain increasingly higher popularity in the years ahead

General-purpose heat source development. Phase II: conceptual designs

International Nuclear Information System (INIS)

Snow, E.C.; Zocher, R.W.; Grinberg, I.M.; Hulbert, L.E.

1978-11-01

Basic geometric module shapes and fuel arrays were studied to determine how well they could be expected to meet the General Purpose Heat Source (GPHS) design requirements. Seven conceptual designs were selected, detailed drawings produced, and these seven concepts analyzed. Three of these design concepts were selected as GPHS Trial Designs to be reanalyzed in more detail and tested. The geometric studies leading to the selection of the seven conceptual designs, the analyses of these designs, and the selection of the three trial designs are discussed

Space shuttle general purpose computers (GPCs) (current and future versions)

Science.gov (United States)

1988-01-01

Current and future versions of general purpose computers (GPCs) for space shuttle orbiters are represented in this frame. The two boxes on the left (AP101B) represent the current GPC configuration, with the input-output processor at far left and the central processing unit (CPU) at its side. The upgraded version combines both elements in a single unit (far right, AP101S).

ABAQUS-EPGEN: a general-purpose finite-element code. Volume 1. User's manual

International Nuclear Information System (INIS)

Hibbitt, H.D.; Karlsson, B.I.; Sorensen, E.P.

1982-10-01

This document is the User's Manual for ABAQUS/EPGEN, a general purpose finite element computer program, designed specifically to serve advanced structural analysis needs. The program contains very general libraries of elements, materials and analysis procedures, and is highly modular, so that complex combinations of features can be put together to model physical problems. The program is aimed at production analysis needs, and for this purpose aspects such as ease-of-use, reliability, flexibility and efficiency have received maximum attention. The input language is designed to make it straightforward to describe complicated models; the analysis procedures are highly automated with the program choosing time or load increments based on user supplied tolerances and controls; and the program offers a wide range of post-processing options for display of the analysis results

Catalog of physical protection equipment. Book 3: Volume VII. General purpose display components

International Nuclear Information System (INIS)

1977-06-01

A catalog of commercially available physical protection equipment has been prepared under MITRE contract AT(49-24)-0376 for use by the U. S. Nuclear Regulatory Commission (NRC). Included is information on barrier structures and equipment, interior and exterior intrusion detection sensors, entry (access) control devices, surveillance and alarm assessment equipment, contraband detection sensors, automated response equipment, general purpose displays and general purpose communications, with one volume devoted to each of these eight areas. For each item of equipment the information included consists of performance, physical, cost and supply/logistics data. The entire catalog is contained in three notebooks for ease in its use by licensing and inspection staff at NRC

An Aerodynamic Database for the Mk 82 General Purpose Low Drag Bomb

National Research Council Canada - National Science Library

Krishnamoorthy, L

1997-01-01

The drag database of the Mk 82 General Purpose Low Drag bomb, the primary gravity weapon in the RAAF inventory, has some shortcomings in the quality and traceability of data, and in the variations due...

Cyclodextrins in delivery systems: Applications

Directory of Open Access Journals (Sweden)

Gaurav Tiwari

2010-01-01

Full Text Available Cyclodextrins (CDs are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. CD molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, CDs have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. CDs are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current CD-based therapeutics is described and possible future applications are discussed. CD-containing polymers are reviewed and their use in drug delivery is presented. Of specific interest is the use of CD-containing polymers to provide unique capabilities for the delivery of nucleic acids. Studies in both humans and animals have shown that CDs can be used to improve drug delivery from almost any type of drug formulation. Currently, there are approximately 30 different pharmaceutical products worldwide containing drug/CD complexes in the market.

15 CFR 744.17 - Restrictions on certain exports and reexports of general purpose microprocessors for “military...

Science.gov (United States)

2010-01-01

... reexports of general purpose microprocessors for âmilitary end-usesâ and to âmilitary end-users.â 744.17...: END-USER AND END-USE BASED § 744.17 Restrictions on certain exports and reexports of general purpose microprocessors for “military end-uses” and to “military end-users.” (a) General prohibition. In addition to the...

Power performance of the general-purpose heat source radioisotope thermoelectric generator

International Nuclear Information System (INIS)

Bennett, G.L.; Lombardo, J.J.; Rock, B.J.

1986-01-01

The General-Purpose Heat Source Radioisotope Thermoelectric Generator (GRHS-RTG) has been developed under the sponsorship of the Department of Energy (DOE) to provide electrical power for the National Aeronautics and Space Administration (NASA) Galileo mission to Jupiter and the joint NASA/European Space Agency (ESA) Ulysses mission to study the polar regions of the sun. A total of five nuclear-heated generators and one electrically heated generator have been built and tested, proving out the design concept and meeting the specification requirements. The GPHS-RTG design is built upon the successful-technology used in the RTGs flown on the two NASA Voyager spacecraft and two US Air Force communications satellites. THe GPHS-RTG converts about 4400 W(t) from the nuclear heat source into at least 285 W(e) at beginning of mission (BOM). The GPHS-RTG consists of two major components: the General-Purpose Heat Source (GPHS) and the Converter. A conceptual drawing of the GPHs-RTG is presented and its design and performance are described

General-purpose event generators for LHC physics

CERN Document Server

Buckley, Andy; Gieseke, Stefan; Grellscheid, David; Hoche, Stefan; Hoeth, Hendrik; Krauss, Frank; Lonnblad, Leif; Nurse, Emily; Richardson, Peter; Schumann, Steffen; Seymour, Michael H.; Sjostrand, Torbjorn; Skands, Peter; Webber, Bryan

2011-01-01

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard-scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond-Standard-Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators ...

General-purpose software for science technology calculation

International Nuclear Information System (INIS)

Aikawa, Hiroshi

1999-01-01

We have developed many general-purpose softwares for parallel processing of science technology calculation. This paper reported six softwares such as STA (Seamless Thinking Aid) basic soft, parallel numerical computation library, grid formation software for parallel computer, real-time visualizing system, parallel benchmark test system and object-oriented parallel programing method. STA is a user interface software to perform a total environment for parallel programing, a network computing environment for various parallel computers and a desktop computing environment via Web. Some examples using the above softwares are explained. One of them is a simultaneous parallel calculation of both analysis of flow and structure of supersonic transport to design of them. The other is various kinds of computer parallel calculations for nuclear fusion reaction such as a molecular dynamic calculation and a calculation of reactor structure and fluid. These softs are opened to the public by the home page {http://guide.tokai.jaeri.go.jp/ccse/}. (S.Y.)

Selecting a general-purpose data compression algorithm

Science.gov (United States)

Mathews, Gary Jason

1995-01-01

The National Space Science Data Center's Common Data Formate (CDF) is capable of storing many types of data such as scalar data items, vectors, and multidimensional arrays of bytes, integers, or floating point values. However, regardless of the dimensionality and data type, the data break down into a sequence of bytes that can be fed into a data compression function to reduce the amount of data without losing data integrity and thus remaining fully reconstructible. Because of the diversity of data types and high performance speed requirements, a general-purpose, fast, simple data compression algorithm is required to incorporate data compression into CDF. The questions to ask are how to evaluate and compare compression algorithms, and what compression algorithm meets all requirements. The object of this paper is to address these questions and determine the most appropriate compression algorithm to use within the CDF data management package that would be applicable to other software packages with similar data compression needs.

General purpose heat source task group. Final report

International Nuclear Information System (INIS)

1979-01-01

The results of thermal analyses and impact tests on a modified design of a 238 Pu-fueled general purpose heat source (GPHS) for spacecraft power supplies are presented. This work was performed to establish the safety of a heat source with pyrolytic graphite insulator shells located either inside or outside the graphite impact shell. This safety is dependent on the degree of aerodynamic heating of the heat source during reentry and on the ability of the heat source capsule to withstand impact after reentry. Analysis of wind tunnel and impact test data result in a recommended GPHS design which should meet all temperature and safety requirements. Further wind tunnel tests, drop tests, and impact tests are recommended to verify the safety of this design

[Violence for educational purpose: Representations of general practitioners in the Paris area, France. A qualitative study].

Science.gov (United States)

de Brie, Claire; Piet, Emmanuelle; Chariot, Patrick

2018-03-01

Violence for educational purpose refers to a modality of education that includes threats, verbal abuse, physical abuse and humiliations. Twenty European countries, not including France, have abolished corporal punishment through explicit laws and regulations. The position of general practitioners in the screening and care of violence for educational purpose in France is unknown. In this study, we aimed to assess the representations of this form of violence among general practitioners. We have performed semi-directed interviews of general practitioners in the Paris, France region (Île-de-France). Interviews were conducted until data saturation was achieved. Interviews were recorded, transcribed and analysed by two investigators. Interviews were conducted with 20 physicians (November 2015-January 2016). General practitioners considered that physical, verbal or psychological abuse had possible negative consequences on children. Uncertainty regarding the consequences of violence was a cause of tolerance towards violence for educational purpose, depending on the act committed and the context, as perceived by nearly all practitioners. General practitioners expressed interest in the field. They cited their own education and experience as the main obstacles to action. Most of them expressed a feeling of failure when they screened or took care of violence for educational purpose. This study suggests that doctors can participate in supporting the parents in the prevention of violence for educational purpose. Support to parents would need specific medical training as well as a societal change. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Foam: A general purpose Monte Carlo cellular algorithm

International Nuclear Information System (INIS)

Jadach, S.

2002-01-01

A general-purpose, self-adapting Monte Carlo (MC) algorithm implemented in the program Foam is described. The high efficiency of the MC, that is small maximum weight or variance of the MC weight is achieved by means of dividing the integration domain into small cells. The cells can be n-dimensional simplices, hyperrectangles or a Cartesian product of them. The grid of cells, called 'foam', is produced in the process of the binary split of the cells. The choice of the next cell to be divided and the position/direction of the division hyperplane is driven by the algorithm which optimizes the ratio of the maximum weight to the average weight or (optionally) the total variance. The algorithm is able to deal, in principle, with an arbitrary pattern of the singularities in the distribution. (author)

Foam A General purpose Monte Carlo Cellular Algorithm

CERN Document Server

Jadach, Stanislaw

2002-01-01

A general-purpose, self-adapting Monte Carlo (MC) algorithm implemented in the program {\\tt Foam} is described. The high efficiency of the MC, that is small maximum weight or variance of the MC weight is achieved by means of dividing the integration domain into small cells. The cells can be $n$-dimensional simplices, hyperrectangles or a Cartesian product of them. The grid of cells, ``foam'', is produced in the process of the binary split of the cells. The next cell to be divided and the position/direction of the division hyperplane is chosen by the algorithm which optimizes the ratio of the maximum weight to the average weight or (optionally) the total variance. The algorithm is able to deal, in principle, with an arbitrary pattern of the singularities in the distribution.

A VMEbus general-purpose data acquisition system

International Nuclear Information System (INIS)

Ninane, A.; Nemry, M.; Martou, J.L.; Somers, F.

1992-01-01

We present a general-purpose, VMEbus based, multiprocessor data acquisition and monitoring system. Events, handled by a master CPU, are kept at the disposal of data storage and monitoring processes which can run on distinct processors. They access either the complete set of data or a fraction of them, minimizing the acquisition dead-time. The system is built with the VxWorks 5.0 real time kernel to which we have added device drivers for data acquisition and monitoring. The acquisition is controlled and the data are displayed on a workstation. The user interface is written in C ++ and re-uses the classes of the Interviews and the NIH libraries. The communication between the control workstation and the VMEbus processors is made through SUN RPCs on an Ethernet link. The system will be used for, CAMAC based, data acquisition for nuclear physics experiments as well as for the VXI data taking with the 4π configuration (100 neutron detectors) of the Brussels-Caen-Louvian-Strasbourg DEMON collaboration. (author)

Installation of new Generation General Purpose Computer (GPC) compact unit

Science.gov (United States)

1991-01-01

In the Kennedy Space Center's (KSC's) Orbiter Processing Facility (OPF) high bay 2, Spacecraft Electronics technician Ed Carter (right), wearing clean suit, prepares for (26864) and installs (26865) the new Generation General Purpose Computer (GPC) compact IBM unit in Atlantis', Orbiter Vehicle (OV) 104's, middeck avionics bay as Orbiter Systems Quality Control technician Doug Snider looks on. Both men work for NASA contractor Lockheed Space Operations Company. All three orbiters are being outfitted with the compact IBM unit, which replaces a two-unit earlier generation computer.

7 CFR 240.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... school year the Department programs agricultural commodities and other foods to States for delivery to... changes in the Price Index for Food Used in Schools and Institutions. Section 6(e)(1) further requires...

Design of a general purpose (RS-232C) analog-to-digital data converter

International Nuclear Information System (INIS)

Ali, Q.

1995-01-01

The purpose of this project is to design a general purpose hardware that interfaces analog devices with any desirable computer supporting the RS-232 interface. The hardware incorporates bidirectional data transmission at 1,200 bps, 2,400 bps, 4800 bps, 9,600 bps, 19,200 pbs and 38400 bps. The communication / processing software has been written in C language that incorporates the idea of the potability of the software from one environment to the other. (author)

The Impact of General Strike on Government Healthcare Delivery in Kerala State in India

Directory of Open Access Journals (Sweden)

Aasems Jacob

2016-01-01

Full Text Available General strike (also known as hartal is used as a mode of protest by organizations and political parties in India. It is generally thought that hartals negatively impact the healthcare delivery in a society. We used the Right to Information Act to obtain data from government health centers in Kerala state in India for four hartal days (H-day and two control days (A-day and B-day for each H-day, from sixteen health centers including 6 Community Health Center (CHC, 6 Secondary Health Center (SHC, and 4 Tertiary Health Center (THC. Data on emergency room visits was available for six HCs. 15 HCs had a statistically significant decrease in the number of outpatient visits on H-day. There was no difference in the number of outpatient visits between the two control days (A and B in 15 HCs, suggesting the lack of a posthartal surge in visits. Median decrease in outpatient visits in CHCs, SHCs, and THCs was 50.4%, 59.5%, and 47.4%, respectively. Hartal did not impact the number of emergency room visits in 6 out of 7 health centers assessed. Our study identified a significant harmful impact on government healthcare delivery due to hartals in Kerala. These findings have major public health implications.

Detectability of T1a lung cancer on digital chest radiographs: an observer-performance comparison among 2-megapixel general-purpose, 2-megapixel medical-purpose, and 3-megapixel medical-purpose liquid-crystal display (LCD) monitors.

Science.gov (United States)

Yabuuchi, Hidetake; Matsuo, Yoshio; Kamitani, Takeshi; Jinnnouchi, Mikako; Yonezawa, Masato; Yamasaki, Yuzo; Nagao, Michinobu; Kawanami, Satoshi; Okamoto, Tatsuro; Sasaki, Masayuki; Honda, Hiroshi

2015-08-01

There has been no comparison of detectability of small lung cancer between general and medical LCD monitors or no comparison of detectability of small lung cancer between solid and part-solid nodules. To compare the detectabilities of T1a lung cancer on chest radiographs on three LCD monitor types: 2-megapixel (MP) for general purpose (General), 2-MP for medical purpose (Medical), and 3-MP-Medical. Radiographs from forty patients with T1aN0M0 primary lung cancer (27 solid nodules, 13 part-solid nodules) and 60 patients with no abnormalities on both chest X-ray and computed tomography (CT) were consecutively collected. Five readers assessed 100 cases for each monitor. The observations were analyzed using receiver operating characteristic (ROC) analysis. A jackknife method was used for statistical analysis. A P value of General, 2-MP-Medical, and 3-MP-Medical LCD monitors were 0.86, 0.89, and 0.89, respectively; there were no significant differences among them. The average AUC for part-solid nodule detection using a 2-MP-General, 2-MP-Medical, and 3-MP-Medical LCD monitors were 0.77, 0.86, and 0.89, respectively. There were significant differences between the 2-MP-General and 2-MP-Medical LCD monitors (P = 0.043) and between the 2-MP-General and 3-MP-Medical LCD monitors (P = 0.027). There was no significant difference between the 2-MP-Medical and 3-MP-Medical LCD monitors. The average AUC for solid nodule detection using a 2-MP-General, 2-MP-Medical, and 3-MP-Medical LCD monitors were 0.90, 0.90, and 0.88, respectively; there were no significant differences among them. The mean AUC values for all and part-solid nodules of the low-experienced readers were significantly lower than those of the high-experienced readers with the 2 M-GP color LCD monitor (P general-purpose LCD monitor was significantly lower than those using medical-purpose LCD monitors. © The Foundation Acta Radiologica 2014.

1 CFR 5.7 - Delivery and mailing.

Science.gov (United States)

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Delivery and mailing. 5.7 Section 5.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.7 Delivery and mailing. The Government Printing Office shall distribute the Federal Register by delivery or by deposit at...

Apple-CORE: Microgrids of SVP cores: flexible, general-purpose, fine-grained hardware concurrency management

NARCIS (Netherlands)

Poss, R.; Lankamp, M.; Yang, Q.; Fu, J.; van Tol, M.W.; Jesshope, C.; Nair, S.

2012-01-01

To harness the potential of CMPs for scalable, energy-efficient performance in general-purpose computers, the Apple-CORE project has co-designed a general machine model and concurrency control interface with dedicated hardware support for concurrency control across multiple cores. Its SVP interface

Developing wearable bio-feedback systems: a general-purpose platform.

Science.gov (United States)

Bianchi, Luigi; Babiloni, Fabio; Cincotti, Febo; Arrivas, Marco; Bollero, Patrizio; Marciani, Maria Grazia

2003-06-01

Microprocessors, even those in PocketPCs, have adequate power for many real-time biofeedback applications for disabled people. This power allows design of portable or wearable devices that are smaller and lighter, and that have longer battery life compared to notebook-based systems. In this paper, we discuss a general-purpose hardware/software solution based on industrial or consumer devices and a C++ framework. Its flexibility and modularity make it adaptable to a wide range of situations. Moreover, its design minimizes system requirements and programming effort, thus allowing efficient systems to be built quickly and easily. Our design has been used to build two brain computer interface systems that were easily ported from the Win32 platform.

Parallelized computation for computer simulation of electrocardiograms using personal computers with multi-core CPU and general-purpose GPU.

Science.gov (United States)

Shen, Wenfeng; Wei, Daming; Xu, Weimin; Zhu, Xin; Yuan, Shizhong

2010-10-01

Biological computations like electrocardiological modelling and simulation usually require high-performance computing environments. This paper introduces an implementation of parallel computation for computer simulation of electrocardiograms (ECGs) in a personal computer environment with an Intel CPU of Core (TM) 2 Quad Q6600 and a GPU of Geforce 8800GT, with software support by OpenMP and CUDA. It was tested in three parallelization device setups: (a) a four-core CPU without a general-purpose GPU, (b) a general-purpose GPU plus 1 core of CPU, and (c) a four-core CPU plus a general-purpose GPU. To effectively take advantage of a multi-core CPU and a general-purpose GPU, an algorithm based on load-prediction dynamic scheduling was developed and applied to setting (c). In the simulation with 1600 time steps, the speedup of the parallel computation as compared to the serial computation was 3.9 in setting (a), 16.8 in setting (b), and 20.0 in setting (c). This study demonstrates that a current PC with a multi-core CPU and a general-purpose GPU provides a good environment for parallel computations in biological modelling and simulation studies. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

General-purpose readout electronics for white neutron source at China Spallation Neutron Source.

Science.gov (United States)

Wang, Q; Cao, P; Qi, X; Yu, T; Ji, X; Xie, L; An, Q

2018-01-01

The under-construction White Neutron Source (WNS) at China Spallation Neutron Source is a facility for accurate measurements of neutron-induced cross section. Seven spectrometers are planned at WNS. As the physical objectives of each spectrometer are different, the requirements for readout electronics are not the same. In order to simplify the development of the readout electronics, this paper presents a general method for detector signal readout. This method has advantages of expansibility and flexibility, which makes it adaptable to most detectors at WNS. In the WNS general-purpose readout electronics, signals from any kinds of detectors are conditioned by a dedicated signal conditioning module corresponding to this detector, and then digitized by a common waveform digitizer with high speed and high precision (1 GSPS at 12-bit) to obtain the full waveform data. The waveform digitizer uses a field programmable gate array chip to process the data stream and trigger information in real time. PXI Express platform is used to support the functionalities of data readout, clock distribution, and trigger information exchange between digitizers and trigger modules. Test results show that the performance of the WNS general-purpose readout electronics can meet the requirements of the WNS spectrometers.

General-purpose event generators for LHC physics

International Nuclear Information System (INIS)

Buckley, Andy; Butterworth, Jonathan; Gieseke, Stefan; Grellscheid, David; Hoeche, Stefan; Hoeth, Hendrik; Krauss, Frank; Loennblad, Leif; Nurse, Emily; Richardson, Peter; Schumann, Steffen; Seymour, Michael H.; Sjoestrand, Torbjoern; Skands, Peter; Webber, Bryan

2011-01-01

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond Standard Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists seeking a deeper insight into the tools available for signal and background simulation at the LHC.

General-purpose event generators for LHC physics

Energy Technology Data Exchange (ETDEWEB)

Buckley, Andy [PPE Group, School of Physics and Astronomy, University of Edinburgh, EH25 9PN (United Kingdom); Butterworth, Jonathan [Department of Physics and Astronomy, University College London, WC1E 6BT (United Kingdom); Gieseke, Stefan [Institute for Theoretical Physics, Karlsruhe Institute of Technology, D-76128 Karlsruhe (Germany); Grellscheid, David [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Hoeche, Stefan [SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Hoeth, Hendrik; Krauss, Frank [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Loennblad, Leif [Department of Astronomy and Theoretical Physics, Lund University (Sweden); PH Department, TH Unit, CERN, CH-1211 Geneva 23 (Switzerland); Nurse, Emily [Department of Physics and Astronomy, University College London, WC1E 6BT (United Kingdom); Richardson, Peter [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Schumann, Steffen [Institute for Theoretical Physics, University of Heidelberg, 69120 Heidelberg (Germany); Seymour, Michael H. [School of Physics and Astronomy, University of Manchester, M13 9PL (United Kingdom); Sjoestrand, Torbjoern [Department of Astronomy and Theoretical Physics, Lund University (Sweden); Skands, Peter [PH Department, TH Unit, CERN, CH-1211 Geneva 23 (Switzerland); Webber, Bryan, E-mail: webber@hep.phy.cam.ac.uk [Cavendish Laboratory, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

2011-07-15

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond Standard Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists seeking a deeper insight into the tools available for signal and background simulation at the LHC.

General-purpose event generators for LHC physics

Energy Technology Data Exchange (ETDEWEB)

Buckley, Andy; /Edinburgh U.; Butterworth, Jonathan; /University Coll. London; Gieseke, Stefan; /Karlsruhe U., ITP; Grellscheid, David; /Durham U., IPPP; Hoche, Stefan; /SLAC; Hoeth, Hendrik; Krauss, Frank; /Durham U., IPPP; Lonnblad, Leif; /Lund U., Dept. Theor. Phys. /CERN; Nurse, Emily; /University Coll. London; Richardson, Peter; /Durham U., IPPP; Schumann, Steffen; /Heidelberg U.; Seymour, Michael H.; /Manchester U.; Sjostrand, Torbjorn; /Lund U., Dept. Theor. Phys.; Skands, Peter; /CERN; Webber, Bryan; /Cambridge U.

2011-03-03

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard-scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond-Standard-Model processes. We describe the principal features of the Ariadne, Herwig++, Pythia 8 and Sherpa generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists wanting a deeper insight into the tools available for signal and background simulation at the LHC.

[Application of the grayscale standard display function to general purpose liquid-crystal display monitors for clinical use].

Science.gov (United States)

Tanaka, Nobukazu; Naka, Kentaro; Sueoka, Masaki; Higashida, Yoshiharu; Morishita, Junji

2010-01-20

Interpretations of medical images have been shifting to soft-copy readings with liquid-crystal display (LCD) monitors. The display function of the medical-grade LCD monitor for soft-copy readings is recommended to calibrate the grayscale standard display function (GSDF) in accordance with the guidelines of Japan and other countries. In this study, the luminance and display function of five models of eight general purpose LCD monitors were measured to gain an understanding of their characteristics. Moreover, the display function (gamma 2.2 or gamma 1.8) of general purpose LCD monitors was converted to GSDF through the use of a look-up table, and the detectability of a simulated lung nodule in the chest x-ray image was examined. As a result, the maximum luminance, contrast ratio, and luminance uniformity of general purpose LCD monitors, except for one model of two LCD monitors, met the management grade 1 standard in the guideline JESRA X-0093-2005. In addition, the detectability of simulated lung nodule in the mediastinal space was obviously improved by converting the display function of a general purpose LCD monitor into GSDF.

Risk of Autism Associated with General Anesthesia during Cesarean Delivery: A Population-Based Birth-Cohort Analysis

Science.gov (United States)

Chien, Li-Nien; Lin, Hsiu-Chen; Shao, Yu-Hsuan Joni; Chiou, Shu-Ti; Chiou, Hung-Yi

2015-01-01

The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the…

A general-purpose process modelling framework for marine energy systems

International Nuclear Information System (INIS)

Dimopoulos, George G.; Georgopoulou, Chariklia A.; Stefanatos, Iason C.; Zymaris, Alexandros S.; Kakalis, Nikolaos M.P.

2014-01-01

Highlights: • Process modelling techniques applied in marine engineering. • Systems engineering approaches to manage the complexity of modern ship machinery. • General purpose modelling framework called COSSMOS. • Mathematical modelling of conservation equations and related chemical – transport phenomena. • Generic library of ship machinery component models. - Abstract: High fuel prices, environmental regulations and current shipping market conditions impose ships to operate in a more efficient and greener way. These drivers lead to the introduction of new technologies, fuels, and operations, increasing the complexity of modern ship energy systems. As a means to manage this complexity, in this paper we present the introduction of systems engineering methodologies in marine engineering via the development of a general-purpose process modelling framework for ships named as DNV COSSMOS. Shifting the focus from components – the standard approach in shipping- to systems, widens the space for optimal design and operation solutions. The associated computer implementation of COSSMOS is a platform that models, simulates and optimises integrated marine energy systems with respect to energy efficiency, emissions, safety/reliability and costs, under both steady-state and dynamic conditions. DNV COSSMOS can be used in assessment and optimisation of design and operation problems in existing vessels, new builds as well as new technologies. The main features and our modelling approach are presented and key capabilities are illustrated via two studies on the thermo-economic design and operation optimisation of a combined cycle system for large bulk carriers, and the transient operation simulation of an electric marine propulsion system

Specialized Monte Carlo codes versus general-purpose Monte Carlo codes

International Nuclear Information System (INIS)

Moskvin, Vadim; DesRosiers, Colleen; Papiez, Lech; Lu, Xiaoyi

2002-01-01

The possibilities of Monte Carlo modeling for dose calculations and optimization treatment are quite limited in radiation oncology applications. The main reason is that the Monte Carlo technique for dose calculations is time consuming while treatment planning may require hundreds of possible cases of dose simulations to be evaluated for dose optimization. The second reason is that general-purpose codes widely used in practice, require an experienced user to customize them for calculations. This paper discusses the concept of Monte Carlo code design that can avoid the main problems that are preventing wide spread use of this simulation technique in medical physics. (authors)

Real-time radar signal processing using GPGPU (general-purpose graphic processing unit)

Science.gov (United States)

Kong, Fanxing; Zhang, Yan Rockee; Cai, Jingxiao; Palmer, Robert D.

2016-05-01

This study introduces a practical approach to develop real-time signal processing chain for general phased array radar on NVIDIA GPUs(Graphical Processing Units) using CUDA (Compute Unified Device Architecture) libraries such as cuBlas and cuFFT, which are adopted from open source libraries and optimized for the NVIDIA GPUs. The processed results are rigorously verified against those from the CPUs. Performance benchmarked in computation time with various input data cube sizes are compared across GPUs and CPUs. Through the analysis, it will be demonstrated that GPGPUs (General Purpose GPU) real-time processing of the array radar data is possible with relatively low-cost commercial GPUs.

A Real-Time Programmer's Tour of General-Purpose L4 Microkernels

OpenAIRE

Ruocco Sergio

2008-01-01

Abstract L4-embedded is a microkernel successfully deployed in mobile devices with soft real-time requirements. It now faces the challenges of tightly integrated systems, in which user interface, multimedia, OS, wireless protocols, and even software-defined radios must run on a single CPU. In this paper we discuss the pros and cons of L4-embedded for real-time systems design, focusing on the issues caused by the extreme speed optimisations it inherited from its general-purpose ancestors. Sinc...

A Real-Time Programmer's Tour of General-Purpose L4 Microkernels

OpenAIRE

Sergio Ruocco

2008-01-01

L4-embedded is a microkernel successfully deployed in mobile devices with soft real-time requirements. It now faces the challenges of tightly integrated systems, in which user interface, multimedia, OS, wireless protocols, and even software-defined radios must run on a single CPU. In this paper we discuss the pros and cons of L4-embedded for real-time systems design, focusing on the issues caused by the extreme speed optimisations it inherited from its general-purpose ancestors. Since these i...

Software design of a general purpose data acquisition and control executive

International Nuclear Information System (INIS)

Labiak, W.G.; Minor, E.G.

1981-01-01

The software design of an executive which performs general purpose data acquisition, monitoring, and control is presented. The executive runs on a memory-based mini or micro-computer and communicates with a disk-based computer where data analysis and display are done. The executive design stresses reliability and versatility, and has yielded software which can provide control and monitoring for widely different hardware systems. Applications of this software on two major fusion energy experiments at Lawrence Livermore National Laboratory will be described

General-purpose chemical analyzer for on-line analyses of radioactive solutions

International Nuclear Information System (INIS)

Spencer, W.A.; Kronberg, J.W.

1983-01-01

An automated analyzer is being developed to perform analytical measurements on radioactive solutions on-line in a hostile environment. This General Purpose Chemical Analyzer (GPCA) samples a process stream, adds reagents, measures solution absorbances or electrode potentials, and automatically calculates the results. The use of modular components, under microprocessor control, permits a single analyzer design to carry out many types of analyses. This paper discusses the more important design criteria for the GPCA, and describes the equipment being tested in a prototype unit

A general-purpose trigger processor system and its application to fast vertex trigger

International Nuclear Information System (INIS)

Hazumi, M.; Banas, E.; Natkaniec, Z.; Ostrowicz, W.

1997-12-01

A general-purpose hardware trigger system has been developed. The system comprises programmable trigger processors and pattern generator/samplers. The hardware design of the system is described. An application as a prototype of the very fast vertex trigger in an asymmetric B-factory at KEK is also explained. (author)

High-Speed General Purpose Genetic Algorithm Processor.

Science.gov (United States)

Hoseini Alinodehi, Seyed Pourya; Moshfe, Sajjad; Saber Zaeimian, Masoumeh; Khoei, Abdollah; Hadidi, Khairollah

2016-07-01

In this paper, an ultrafast steady-state genetic algorithm processor (GAP) is presented. Due to the heavy computational load of genetic algorithms (GAs), they usually take a long time to find optimum solutions. Hardware implementation is a significant approach to overcome the problem by speeding up the GAs procedure. Hence, we designed a digital CMOS implementation of GA in [Formula: see text] process. The proposed processor is not bounded to a specific application. Indeed, it is a general-purpose processor, which is capable of performing optimization in any possible application. Utilizing speed-boosting techniques, such as pipeline scheme, parallel coarse-grained processing, parallel fitness computation, parallel selection of parents, dual-population scheme, and support for pipelined fitness computation, the proposed processor significantly reduces the processing time. Furthermore, by relying on a built-in discard operator the proposed hardware may be used in constrained problems that are very common in control applications. In the proposed design, a large search space is achievable through the bit string length extension of individuals in the genetic population by connecting the 32-bit GAPs. In addition, the proposed processor supports parallel processing, in which the GAs procedure can be run on several connected processors simultaneously.

Implementation elements for conversion of general-purpose freeway lane into high-occupancy-vehicle lane

Science.gov (United States)

1997-01-01

Conversion of a general-purpose freeway into a high-occupancy-vehicle (HOV) lane is an alternative to infrastructure addition for HOV system implementation. Research indicates that lane conversion is feasible technically if sufficient HOV usage and m...

General Purpose Technologies and their Implications for International Trade

Directory of Open Access Journals (Sweden)

Petsas Iordanis

2015-09-01

Full Text Available This paper develops a simple model of trade and “quality-ladders” growth without scale effects to study the implications of general purpose technologies (GPTs for international trade. GPTs refer to a certain type of drastic innovations, such as electrification, the transistor, and the Internet, that are characterized by the pervasiveness in use, innovational complementarities, and technological dynamism. The model presents a two-country (Home and Foreign dynamic general equilibrium framework and incorporates GPT diffusion within Home that exhibits endogenous Schumpeterian growth. The model analyzes the long-run and transitional dynamic effects of a new GPT on the pattern of trade and relative wages. The main findings of the paper are: 1 when the GPT diffusion across industries is governed by S-curve dynamics, there are two steady-state equilibria: the initial steadystate arises before the adoption of the new GPT and the final one is reached after the GPT diffusion process has been completed, 2 when all industries at Home have adopted the new GPT, Home enjoys comparative advantage in a greater range of industries compared to Foreign, 3 during the transitional dynamics, Foreign gains back its competitiveness in some of the industries that lost its comparative advantage to Home.

Comparative assessment of plasmid DNA delivery by encapsulation ...

African Journals Online (AJOL)

Tropical Journal of Pharmaceutical Research January 2018; 17 (1): 1-10 ... Purpose: To compare the gene delivery effectiveness of plasmid DNA (pDNA) ..... Intramuscular delivery of DNA ... copolymeric system for gene delivery in complete.

38 CFR 21.4505 - Check delivery.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Check delivery. 21.4505...) VOCATIONAL REHABILITATION AND EDUCATION Education Loans § 21.4505 Check delivery. (a) General. Education... surviving spouse is enrolled for delivery by the educational institution. (b) Delivery and certification. (1...

A planning and delivery study of a rotational IMRT technique with burst delivery

International Nuclear Information System (INIS)

Kainz, Kristofer; Chen, Guang-Pei; Chang, Yu-Wen; Prah, Douglas; Sharon Qi, X.; Shukla, Himanshu P.; Stahl, Johannes; Allen Li, X.

2011-01-01

Purpose: A novel rotational IMRT (rIMRT) technique using burst delivery (continuous gantry rotation with beam off during MLC repositioning) is investigated. The authors evaluate the plan quality and delivery efficiency and accuracy of this dynamic technique with a conventional flat 6 MV photon beam. Methods: Burst-delivery rIMRT was implemented in a planning system and delivered with a 160-MLC linac. Ten rIMRT plans were generated for five anonymized patient cases encompassing head and neck, brain, prostate, and prone breast. All plans were analyzed retrospectively and not used for treatment. Among the varied plan parameters were the number of optimization points, number of arcs, gantry speed, and gantry angle range (alpha) over which the beam is turned on at each optimization point. Combined rotational/step-and-shoot rIMRT plans were also created by superimposing multiple-segment static fields at several optimization points. The rIMRT trial plans were compared with each other and with plans generated using helical tomotherapy and VMAT. Burst-mode rotational IMRT plans were delivered and verified using a diode array, ionization chambers, thermoluminescent dosimeters, and film. Results: Burst-mode rIMRT can achieve plan quality comparable to helical tomotherapy, while the former may lead to slightly better OAR sparing for certain cases and the latter generally achieves slightly lower hot spots. Few instances were found in which increasing the number of optimization points above 36, or superimposing step-and-shoot IMRT segments, led to statistically significant improvements in OAR sparing. Using an additional rIMRT partial arc yielded substantial OAR dose improvements for the brain case. Measured doses from the rIMRT plan delivery were within 4% of the plan calculation in low dose gradient regions. Delivery time range was 228-375 s for single-arc rIMRT 200-cGy prescription with a 300 MU/min dose rate, comparable to tomotherapy and VMAT. Conclusions: Rotational IMRT

General-purpose Monte Carlo codes for neutron and photon transport calculations. MVP version 3

International Nuclear Information System (INIS)

Nagaya, Yasunobu

2017-01-01

JAEA has developed a general-purpose neutron/photon transport Monte Carlo code MVP. This paper describes the recent development of the MVP code and reviews the basic features and capabilities. In addition, capabilities implemented in Version 3 are also described. (author)

Applications for a general purpose optical beam propagation code

International Nuclear Information System (INIS)

Munroe, J.L.; Wallace, N.W.

1987-01-01

Real world beam propagation and diffraction problems can rarely be solved by the analytical expressions commonly found in optics and lasers textbooks. These equations are typically valid only for paraxial geometries, for specific boundary conditions (e.g., infinite apertures), or for special assumptions (e.g., at focus). Numerical techniques must be used to solve the equations for the general case. LOTS, a public domain numerical beam propagation software package developed for this purpose, is a widely used and proven tool. The graphical presentation of results combined with a well designed command language make LOTS particularly user-friendly, and the recent implementation of LOTS on the IBM PC/XT family of desktop computes will make this capability available to a much larger group of users. This paper surveys several applications demonstrating the need for such a capability

Some thermo-electromagnetic applications to fusion technology of a general purpose CAD package

International Nuclear Information System (INIS)

Girdinio, P.; Molfino, P.; Molinari, G.; Raia, G.; Rosatelli, F.; Viviani, A.

1985-01-01

A general purpose CAD package is applied to the solution of problems related to fusion technology. The problems solved are the interacting electromagnetic and thermal fields in a resistive toroidal coil and the design of the poloidal field coils in Tokamak machines. In both cases, the procedure used is reported and the results obtained are displayed and discussed

Some thermo-electromagnetic applications to fusion technology of a general purpose CAD package

International Nuclear Information System (INIS)

Girdinio, P.; Molfino, P.; Molinari, G.; Viviani, A.; Raia, G.; Rosatelli, F.

1984-01-01

A general purpose CAD package is applied to the solution of problems related to fusion technology. The problems solved are the interacting electromagnetic and thermal fields in a resistive toroidal coil and the design of the poloidal field coils in Tokamak machines. In both cases, the procedure used is reported and the results obtained are displayed and discussed. (author)

Development of general-purpose particle and heavy ion transport monte carlo code

International Nuclear Information System (INIS)

Iwase, Hiroshi; Nakamura, Takashi; Niita, Koji

2002-01-01

The high-energy particle transport code NMTC/JAM, which has been developed at JAERI, was improved for the high-energy heavy ion transport calculation by incorporating the JQMD code, the SPAR code and the Shen formula. The new NMTC/JAM named PHITS (Particle and Heavy-Ion Transport code System) is the first general-purpose heavy ion transport Monte Carlo code over the incident energies from several MeV/nucleon to several GeV/nucleon. (author)

Floating Microparticulate Oral Diltiazem Hydrochloride Delivery ...

African Journals Online (AJOL)

Purpose: To formulate and evaluate floating microparticulate oral diltiazem delivery system for possible delivery to the heart. Method: Floating microspheres were prepared using cellulose acetate and Eudragit RS100 polymers by emulsion solvent evaporation technique. The dried floating microspheres were evaluated for ...

A prepaid case study: Ready Credit’s general-purpose & transit-fare programs

OpenAIRE

Philip Keitel

2012-01-01

Today, prepaid cards are used in dozens of payment applications. To examine the most recent developments, the Payment Cards Center of the Federal Reserve Bank of Philadelphia hosted a workshop on August 22, 2011. Leading the workshop was Tim Walsh, president and chief executive officer of Ready Credit Corporation, a firm that developed network-branded prepaid cards for use in transit-fare systems and also markets general-purpose, reloadable prepaid cards to consumers. Walsh discussed the uniq...

Improved overall delivery documentation following implementation of a standardized shoulder dystocia delivery form

Science.gov (United States)

Moragianni, Vasiliki A.; Hacker, Michele R.; Craparo, Frank J.

2013-01-01

Objective Our objective was to evaluate whether using a standardized shoulder dystocia delivery form improved documentation. A standardized delivery form was added to our institution’s obstetrical record in August 2003. Methods A retrospective cohort study was conducted comparing 100 vaginal deliveries complicated by shoulder dystocia before, and 81 after implementation of the standardized delivery form. The two groups were compared in terms of obstetric characteristics, neonatal outcomes and documentation components. Results Charts that included the standardized delivery form were more likely to contain documentation of estimated fetal weight (82.7% vs. 39.0% without the form, Pdystocia, and second stage duration. Conclusions Inclusion of a standardized form in the delivery record improves the rate of documentation of both shoulder dystocia-specific and general delivery components. PMID:22017330

Comparison of progressive addition lenses for general purpose and for computer vision: an office field study.

Science.gov (United States)

Jaschinski, Wolfgang; König, Mirjam; Mekontso, Tiofil M; Ohlendorf, Arne; Welscher, Monique

2015-05-01

Two types of progressive addition lenses (PALs) were compared in an office field study: 1. General purpose PALs with continuous clear vision between infinity and near reading distances and 2. Computer vision PALs with a wider zone of clear vision at the monitor and in near vision but no clear distance vision. Twenty-three presbyopic participants wore each type of lens for two weeks in a double-masked four-week quasi-experimental procedure that included an adaptation phase (Weeks 1 and 2) and a test phase (Weeks 3 and 4). Questionnaires on visual and musculoskeletal conditions as well as preferences regarding the type of lenses were administered. After eight more weeks of free use of the spectacles, the preferences were assessed again. The ergonomic conditions were analysed from photographs. Head inclination when looking at the monitor was significantly lower by 2.3 degrees with the computer vision PALs than with the general purpose PALs. Vision at the monitor was judged significantly better with computer PALs, while distance vision was judged better with general purpose PALs; however, the reported advantage of computer vision PALs differed in extent between participants. Accordingly, 61 per cent of the participants preferred the computer vision PALs, when asked without information about lens design. After full information about lens characteristics and additional eight weeks of free spectacle use, 44 per cent preferred the computer vision PALs. On average, computer vision PALs were rated significantly better with respect to vision at the monitor during the experimental part of the study. In the final forced-choice ratings, approximately half of the participants preferred either the computer vision PAL or the general purpose PAL. Individual factors seem to play a role in this preference and in the rated advantage of computer vision PALs. © 2015 The Authors. Clinical and Experimental Optometry © 2015 Optometry Australia.

Economic selection index development for Beefmaster cattle II: General-purpose breeding objective.

Science.gov (United States)

Ochsner, K P; MacNeil, M D; Lewis, R M; Spangler, M L

2017-05-01

An economic selection index was developed for Beefmaster cattle in a general-purpose production system in which bulls are mated to a combination of heifers and mature cows, with resulting progeny retained as replacements or sold at weaning. National average prices from 2010 to 2014 were used to establish income and expenses for the system. Genetic parameters were obtained from the literature. Economic values were estimated by simulating 100,000 animals and approximating the partial derivatives of the profit function by perturbing traits 1 at a time, by 1 unit, while holding the other traits constant at their respective means. Relative economic values for the objective traits calving difficultly direct (CDd), calving difficulty maternal (CDm), weaning weight direct (WWd), weaning weight maternal (WWm), mature cow weight (MW), and heifer pregnancy (HP) were -2.11, -1.53, 18.49, 11.28, -33.46, and 1.19, respectively. Consequently, under the scenario assumed herein, the greatest improvements in profitability could be made by decreasing maintenance energy costs associated with MW followed by improvements in weaning weight. The accuracy of the index lies between 0.218 (phenotypic-based index selection) and 0.428 (breeding values known without error). Implementation of this index would facilitate genetic improvement and increase profitability of Beefmaster cattle operations with a general-purpose breeding objective when replacement females are retained and with weaned calves as the sale end point.

General Purpose Data-Driven Online System Health Monitoring with Applications to Space Operations

Science.gov (United States)

Iverson, David L.; Spirkovska, Lilly; Schwabacher, Mark

2010-01-01

Modern space transportation and ground support system designs are becoming increasingly sophisticated and complex. Determining the health state of these systems using traditional parameter limit checking, or model-based or rule-based methods is becoming more difficult as the number of sensors and component interactions grows. Data-driven monitoring techniques have been developed to address these issues by analyzing system operations data to automatically characterize normal system behavior. System health can be monitored by comparing real-time operating data with these nominal characterizations, providing detection of anomalous data signatures indicative of system faults, failures, or precursors of significant failures. The Inductive Monitoring System (IMS) is a general purpose, data-driven system health monitoring software tool that has been successfully applied to several aerospace applications and is under evaluation for anomaly detection in vehicle and ground equipment for next generation launch systems. After an introduction to IMS application development, we discuss these NASA online monitoring applications, including the integration of IMS with complementary model-based and rule-based methods. Although the examples presented in this paper are from space operations applications, IMS is a general-purpose health-monitoring tool that is also applicable to power generation and transmission system monitoring.

Operation of general purpose stepping motor controllers at the National Synchrotron Light Source

International Nuclear Information System (INIS)

Stubblefield, F.W.

1987-01-01

A prototype and four copies of a general purpose subsystem for mechanical positioning of detectors, samples, and beam line optical elements which constitute experiments at the National Synchrotron Light Source facility of Brookhaven National Laboratory have been constructed and placed into operation. Construction of a sixth subsystem is nearing completion. The subsystems effect mechanical positioning by controlling a set of stepping motors and their associated position encoders. The units are general purpose in the sense that they receive commands over a standard 9600 baud asynchronous serial line compatible with the RS-232-C electrical signal standard, generate TTL-compatible streams of stepping pulses which can be used with a wide variety of stepping motors, and read back position values from a number of different types and models of position encoder. The basic structure of the motor controller subsystem is briefly reviewed. Short descriptions of the positioning apparatus actuated at each of the test and experiment stations employing a motor control unit are given. Additions and enhancements to the sub-system made in response to problems indicated by actual operation of the four installed units are described in more detail

Operation of general purpose stepping motor controllers at the National Synchrotron Light Source

International Nuclear Information System (INIS)

Stubblefield, F.W.

1986-10-01

A prototype and four copies of a general purpose subsystem for mechanical positioning of detectors, samples, and beam line optical elements which constitute experiments at the National Synchrotron Light Source facility of Brookhaven National Laboratory have been constructed and placed into operation. Construction of a sixth subsystem is nearing completion. The subsystems effect mechanical positioning by controlling a set of stepping motors and their associated position encoders. The units are general purpose in the sense that they receive commands over a standard 9600 baud asynchronous serial line compatible with the RS-232-C electrical signal standard, generate TTL-compatible streams of stepping pulses which can be used with a wide variety of stepping motors, and read back position values from a number of different types and models of position encoder. The basic structure of the motor controller subsystem will be briefly reviewed. Short descriptions of the positioning apparatus actuated at each of the test and experiment stations employing a motor control unit are given. Additions and enhancements to the subsystem made in response to problems indicated by actual operation of the four installed units are described in more detail

A new general purpose event horizon finder for 3D numerical spacetimes

International Nuclear Information System (INIS)

Diener, Peter

2003-01-01

I present a new general purpose event horizon finder for full 3D numerical spacetimes. It works by evolving a complete null surface backwards in time. The null surface is described as the zero-level set of a scalar function, which in principle is defined everywhere. This description of the surface allows the surface, trivially, to change topology, making this event horizon finder able to handle numerical spacetimes where two (or more) black holes merge into a single final black hole

Report on the operation and utilization of general purpose use computer system 2001

Energy Technology Data Exchange (ETDEWEB)

Watanabe, Kunihiko; Watanabe, Reiko; Tsugawa, Kazuko; Tsuda, Kenzo; Yamamoto, Takashi; Nakamura, Osamu; Kamimura, Tetsuo [National Inst. for Fusion Science, Toki, Gifu (Japan)

2001-09-01

The General Purpose Use Computer System of National Institute for Fusion Science was replaced in January, 2001. The System is almost fully used after the first three months operation. Reported here is the process of the introduction of the new system and the state of the operation and utilization of the System between January and March, 2001, especially the detailed utilization of March. (author)

A general purpose program system for high energy physics experiment data acquisition and analysis

International Nuclear Information System (INIS)

Li Shuren; Xing Yuguo; Jin Bingnian

1985-01-01

This paper introduced the functions, structure and system generation of a general purpose program system (Fermilab MULTI) for high energy physics experiment data acquisition and analysis. Works concerning the reconstruction of MULTI system level 0.5 which can be run on the computer PDP-11/23 are also introduced briefly

Child first language and adult second language are both tied to general-purpose learning systems.

Science.gov (United States)

Hamrick, Phillip; Lum, Jarrad A G; Ullman, Michael T

2018-02-13

Do the mechanisms underlying language in fact serve general-purpose functions that preexist this uniquely human capacity? To address this contentious and empirically challenging issue, we systematically tested the predictions of a well-studied neurocognitive theory of language motivated by evolutionary principles. Multiple metaanalyses were performed to examine predicted links between language and two general-purpose learning systems, declarative and procedural memory. The results tied lexical abilities to learning only in declarative memory, while grammar was linked to learning in both systems in both child first language and adult second language, in specific ways. In second language learners, grammar was associated with only declarative memory at lower language experience, but with only procedural memory at higher experience. The findings yielded large effect sizes and held consistently across languages, language families, linguistic structures, and tasks, underscoring their reliability and validity. The results, which met the predicted pattern, provide comprehensive evidence that language is tied to general-purpose systems both in children acquiring their native language and adults learning an additional language. Crucially, if language learning relies on these systems, then our extensive knowledge of the systems from animal and human studies may also apply to this domain, leading to predictions that might be unwarranted in the more circumscribed study of language. Thus, by demonstrating a role for these systems in language, the findings simultaneously lay a foundation for potentially important advances in the study of this critical domain.

The Efficiency of Linda for General Purpose Scientific Programming

Directory of Open Access Journals (Sweden)

Timothy G. Mattson

1994-01-01

Full Text Available Linda (Linda is a registered trademark of Scientific Computing Associates, Inc. is a programming language for coordinating the execution and interaction of processes. When combined with a language for computation (such as C or Fortran, the resulting hybrid language can be used to write portable programs for parallel and distributed multiple instruction multiple data (MIMD computers. The Linda programming model is based on operations that read, write, and erase a virtual shared memory. It is easy to use, and lets the programmer code in a very expressive, uncoupled programming style. These benefits, however, are of little value unless Linda programs execute efficiently. The goal of this article is to demonstrate that Linda programs are efficient making Linda an effective general purpose tool for programming MIMD parallel computers. Two arguments for Linda's efficiency are given; the first is based on Linda's implementation and the second on a range of case studies spanning a complete set of parallel algorithm classes.

An Evaluation of Classroom Activities and Exercises in ELT Classroom for General Purposes Course

Science.gov (United States)

Zohrabi, Mohammad

2011-01-01

It is through effective implementation of activities and exercises which students can be motivated and consequently lead to language learning. However, as an insider, the experience of teaching English for General Purposes (EGP) course indicates that it has some problems which need to be modified. In order to evaluate the EGP course,…

Noninvasive ocular drug delivery: potential transcorneal and other alternative delivery routes for therapeutic molecules in glaucoma.

Science.gov (United States)

Foldvari, Marianna

2014-01-01

Drug delivery to the eye is made difficult by multiple barriers (such as the tear film, cornea, and vitreous) between the surface of the eye and the treatment site. These barriers are difficult to surmount for the purposes of drug delivery without causing toxicity. Using nanotechnology tools to control, manipulate, and study delivery systems, new approaches to delivering drugs, genes, and antigens that are effective and safe can be developed. Topical administration to the ocular surface would be the safest method for delivery, as it is noninvasive and painless compared with other delivery methods. However, there is only limited success using topical delivery methods, especially for gene therapy. Current thinking on treatments of the future enabled by nanodelivery systems and the identification of target specificity parameters that require deeper understanding to develop successful topical delivery systems for glaucoma is highlighted.

21 CFR 880.6890 - General purpose disinfectants.

Science.gov (United States)

2010-04-01

... (CONTINUED) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General Hospital and Personal Use... disinfectant is a germicide intended to process noncritical medical devices and equipment surfaces. A general... prior to terminal sterilization or high level disinfection. Noncritical medical devices make only...

Gestational obesity as a determinant of general anesthesia technique for caesarean delivery: a case report.

Directory of Open Access Journals (Sweden)

José Ricardo Navarro Vargas

2009-07-01

Full Text Available Background. The incidence of obesity has undergone a dramatic increase around the world during the last few years. Such epidemic behavior has been associated with obstetric patient’s frequent presentation of different stages of obesity when undergoing anesthetic procedure. Obesity in pregnant women involves the risk of adverse maternal and fetal outcomes. Hypertension and preeclampsia, diabetes, fetal macrosomia, caesarean delivery, difficult airway management and neuroaxial techniques are more likely to be performed in this group of patients. Materials and methods. This is a case report of a morbid obese patient scheduled for caesarean delivery and tubal ligation. Regional, spinal and epidural techniques were attempted for surgery with unsuccessful results; this entails general anesthesia for surgery. The literature on complications due to obesity during pregnancy was reviewed, emphasising relevance for the anesthesiologist. Conclusion. Obesity, especially morbid obesity in pregnant women, represents a challenge for anesthesia management. Updated knowledge of physiology and the conditions related to obesity in pregnancy is necessary; medical services must be prepared to provide optimum and safe obstetric anesthesia, analgesia and post-operation care.

Waste feed delivery test and evaluation plan

Energy Technology Data Exchange (ETDEWEB)

O' TOOLE, S.M.

1999-09-30

This plan documents the Waste Feed Delivery Program test and evaluation planning and implementation approach. The purpose of this document is to define and communicate the Waste Feed Delivery Program Test and Evaluation scope, objectives, planning and implementation approach.

Waste feed delivery test and evaluation plan

International Nuclear Information System (INIS)

O'TOOLE, S.M.

1999-01-01

This plan documents the Waste Feed Delivery Program test and evaluation planning and implementation approach. The purpose of this document is to define and communicate the Waste Feed Delivery Program Test and Evaluation scope, objectives, planning and implementation approach

Knowledge Management Systems as an Interdisciplinary Communication and Personalized General-Purpose Technology

Directory of Open Access Journals (Sweden)

Ulrich Schmitt

2015-10-01

Full Text Available As drivers of human civilization, Knowledge Management (KM processes have co-evolved in line with General-Purpose-Technologies (GPT, such as writing, printing, and information and communication systems. As evidenced by the recent shift from information scarcity to abundance, GPTs are capable of drastically altering societies due to their game-changing impact on our spheres of work and personal development. This paper looks at the prospect of whether a novel Personal Knowledge Management (PKM concept supported by a prototype system has got what it takes to grow into a transformative General-Purpose-Technology. Following up on a series of papers, the KM scenario of a decentralizing revolution where individuals and self-organized groups yield more power and autonomy is examined according to a GPT's essential characteristics, including a wide scope for improvement and elaboration (in people's private, professional and societal life, applicability across a broad range of uses in a wide variety of products and processes (in multi-disciplinary educational and work contexts, and strong complementarities with existing or potential new technologies (like organizational KM Systems and a proposed World Heritage of Memes Repository. The result portrays the PKM concept as a strong candidate due to its personal, autonomous, bottom-up, collaborative, interdisciplinary, and creativity-supporting approach destined to advance the availability, quantity, and quality of the world extelligence and to allow for a wider sharing and faster diffusion of ideas across current disciplinary and opportunity divides.

Use of general purpose graphics processing units with MODFLOW

Science.gov (United States)

Hughes, Joseph D.; White, Jeremy T.

2013-01-01

To evaluate the use of general-purpose graphics processing units (GPGPUs) to improve the performance of MODFLOW, an unstructured preconditioned conjugate gradient (UPCG) solver has been developed. The UPCG solver uses a compressed sparse row storage scheme and includes Jacobi, zero fill-in incomplete, and modified-incomplete lower-upper (LU) factorization, and generalized least-squares polynomial preconditioners. The UPCG solver also includes options for sequential and parallel solution on the central processing unit (CPU) using OpenMP. For simulations utilizing the GPGPU, all basic linear algebra operations are performed on the GPGPU; memory copies between the central processing unit CPU and GPCPU occur prior to the first iteration of the UPCG solver and after satisfying head and flow criteria or exceeding a maximum number of iterations. The efficiency of the UPCG solver for GPGPU and CPU solutions is benchmarked using simulations of a synthetic, heterogeneous unconfined aquifer with tens of thousands to millions of active grid cells. Testing indicates GPGPU speedups on the order of 2 to 8, relative to the standard MODFLOW preconditioned conjugate gradient (PCG) solver, can be achieved when (1) memory copies between the CPU and GPGPU are optimized, (2) the percentage of time performing memory copies between the CPU and GPGPU is small relative to the calculation time, (3) high-performance GPGPU cards are utilized, and (4) CPU-GPGPU combinations are used to execute sequential operations that are difficult to parallelize. Furthermore, UPCG solver testing indicates GPGPU speedups exceed parallel CPU speedups achieved using OpenMP on multicore CPUs for preconditioners that can be easily parallelized.

Organization and change in general practice

DEFF Research Database (Denmark)

Andersen, John Sahl

Organization and change in general practice Abstract for a symposium at Nordic Congress for General Practice Thursday 14 May at 15.30-17.00 General practice is under increasing pressure to assume new tasks, adopt new technologies and engage in new organizational structures. However, in a field...... of multiple actors and concerns such visions are rarely straightforward to realize. This symposium explores the significance of various organizational, cultural and regulative features of general practice in relation to proposals for change in the sector. Presentations: Thorkil Thorsen, Marius Kousgaard...... primary care. One purpose is to give more freedom to the patients to choose care-givers. Another is to create a more competitive health care system. These reforms will be evaluated in a research project to be presented. Chairman: John Sahl Andersen MESH-terms: Delivery of Health Care, Health Care Reform...

High vacuum general purpose scattering chamber for nuclear reaction study

International Nuclear Information System (INIS)

Suresh Kumar; Ojha, S.C.

2003-01-01

To study the nuclear reactions induced by beam from medium energy accelerators, one of the most common facility required is a scattering chamber. In the scattering chamber, projectile collides with the target nucleus and the scattered reaction products are detected with various type of nuclear detector at different angles with respect to the beam. The experiments are performed under high vacuum to minimize the background reaction and the energy losses of the charged particles. To make the chamber general purpose various requirement of the experiments are incorporated into it. Changing of targets, changing angle of various detectors while in vacuum are the most desired features. The other features like ascertaining the beam spot size and position on the target, minimizing the background counts by proper beam dump, accurate positioning of the detector as per plan etc. are some of the important requirements

The RHIC general purpose multiplexed analog to digital converter system

International Nuclear Information System (INIS)

Michnoff, R.

1995-01-01

A general purpose multiplexed analog to digital converter system is currently under development to support acquisition of analog signals for the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory. The system consists of a custom intelligent VME based controller module (V113) and a 14-bit 64 channel multiplexed A/D converter module (V114). The design features two independent scan groups, where one scan group is capable of acquiring 64 channels at 60 Hz, concurrently with the second scan group acquiring data at an aggregate rate of up to 80 k samples/second. An interface to the RHIC serially encoded event line is used to synchronize acquisition. Data is stored in a circular static RAM buffer on the controller module, then transferred to a commercial VMEbus CPU board and higher level workstations for plotting, report Generation, analysis and storage

Using a cognitive architecture for general purpose service robot control

Science.gov (United States)

Puigbo, Jordi-Ysard; Pumarola, Albert; Angulo, Cecilio; Tellez, Ricardo

2015-04-01

A humanoid service robot equipped with a set of simple action skills including navigating, grasping, recognising objects or people, among others, is considered in this paper. By using those skills the robot should complete a voice command expressed in natural language encoding a complex task (defined as the concatenation of a number of those basic skills). As a main feature, no traditional planner has been used to decide skills to be activated, as well as in which sequence. Instead, the SOAR cognitive architecture acts as the reasoner by selecting which action the robot should complete, addressing it towards the goal. Our proposal allows to include new goals for the robot just by adding new skills (without the need to encode new plans). The proposed architecture has been tested on a human-sized humanoid robot, REEM, acting as a general purpose service robot.

Effect of induction-delivery and uterine-delivery on apgar scoring of the newborn.

Directory of Open Access Journals (Sweden)

Kamat S

1991-07-01

Full Text Available Very short or prolonged induction-delivery interval (i.e. less than 5 minutes or more than 15 minutes and uterine-delivery interval of more than 90 seconds has a definite effect on the apgar scoring of a newborn especially when general anaesthesia is administered as compared to regional anaesthesia for caesarean section.

Interfacial Properties of EXXPRO(TM) and General Purpose Elastomers

Science.gov (United States)

Zhang, Y.; Rafailovich, M.; Sokolov, Jon; Qu, S.; Ge, S.; Ngyuen, D.; Li, Z.; Peiffer, D.; Song, L.; Dias, J. A.; McElrath, K. O.

1998-03-01

EXXPRO(Trademark) elastomers are used for tires and many other applications. This elastomer (denoted as BIMS) is a random copolymer of p-methylstyrene (MS) and polyisobutylene (I) with varying degrees of PMS content and bromination (B) on the p-methyl group. BIMS is impermeable to gases, and has good heat, ozone and flex resistance. Very often general purpose elastomers are blended with BIMS. The interfacial width between polybutadiene and BIMS is a sensitive function of the Br level and PMS content. By neutron reflectivity (NR), we studied the dynamics of interface formation as a function of time and temperature for BIMS with varying degrees of PMS and Br. We found that in addition to the bulk parameters, the total film thickness and the proximity of an interactive surface can affect the interfacial interaction rates. The interfacial properties can also be modified by inclusion of particles, such as carbon black (a filler component in tire rubbers). Results will be presented on the relation between the interfacial width as measured by NR and compatibilization studies via AFM and LFM.

Foam A General Purpose Cellular Monte Carlo Event Generator

CERN Document Server

Jadach, Stanislaw

2003-01-01

A general purpose, self-adapting, Monte Carlo (MC) event generator (simulator) is described. The high efficiency of the MC, that is small maximum weight or variance of the MC weight is achieved by means of dividing the integration domain into small cells. The cells can be $n$-dimensional simplices, hyperrectangles or Cartesian product of them. The grid of cells, called ``foam'', is produced in the process of the binary split of the cells. The choice of the next cell to be divided and the position/direction of the division hyper-plane is driven by the algorithm which optimizes the ratio of the maximum weight to the average weight or (optionally) the total variance. The algorithm is able to deal, in principle, with an arbitrary pattern of the singularities in the distribution. As any MC generator, it can also be used for the MC integration. With the typical personal computer CPU, the program is able to perform adaptive integration/simulation at relatively small number of dimensions ($\\leq 16$). With the continu...

Fractional CO(2) laser-assisted drug delivery

DEFF Research Database (Denmark)

Haedersdal, Merete; Sakamoto, Fernanda H; Farinelli, William A

2010-01-01

Ablative fractional resurfacing (AFR) creates vertical channels that might assist the delivery of topically applied drugs into skin. The purpose of this study was to evaluate drug delivery by CO(2) laser AFR using methyl 5-aminolevulinate (MAL), a porphyrin precursor, as a test drug....

Determinants of Home Delivery among Women attending Antenatal ...

African Journals Online (AJOL)

USER

Abstract. Unskilled home delivery is a threat to maternal and child health. ... home delivery after attending antenatal services, this study employed a cross-sectional design and a non-probability purposive ... deaths occur in sub-Saharan Africa.

Design of General-purpose Industrial signal acquisition system in a large scientific device

Science.gov (United States)

Ren, Bin; Yang, Lei

2018-02-01

In order to measure the industrial signal of a large scientific device experiment, a set of industrial data general-purpose acquisition system has been designed. It can collect 4~20mA current signal and 0~10V voltage signal. Through the practical experiments, it shows that the system is flexible, reliable, convenient and economical, and the system has characters of high definition and strong anti-interference ability. Thus, the system fully meets the design requirements..

APL/JHU free flight tests of the General Purpose Heat Source module. Testing: 5-7 March 1984

International Nuclear Information System (INIS)

Baker, W.M. II.

1984-01-01

Purpose of the test was to obtain statistical information on the dynamics of the General Purpose Heat Source (GPHS) module at terminal speeds. Models were designed to aerodynamically and dynamically represent the GPHS module. Normal and high speed photographic coverage documented the motion of the models. This report documents test parameters and techniques for the free-spin tests. It does not include data analysis

Development of a large-scale general purpose two-phase flow analysis code

International Nuclear Information System (INIS)

Terasaka, Haruo; Shimizu, Sensuke

2001-01-01

A general purpose three-dimensional two-phase flow analysis code has been developed for solving large-scale problems in industrial fields. The code uses a two-fluid model to describe the conservation equations for two-phase flow in order to be applicable to various phenomena. Complicated geometrical conditions are modeled by FAVOR method in structured grid systems, and the discretization equations are solved by a modified SIMPLEST scheme. To reduce computing time a matrix solver for the pressure correction equation is parallelized with OpenMP. Results of numerical examples show that the accurate solutions can be obtained efficiently and stably. (author)

Root Effect Haemoglobins in Fish May Greatly Enhance General Oxygen Delivery Relative to Other Vertebrates.

Directory of Open Access Journals (Sweden)

Jodie L Rummer

Full Text Available The teleost fishes represent over half of all extant vertebrates; they occupy nearly every body of water and in doing so, occupy a diverse array of environmental conditions. We propose that their success is related to a unique oxygen (O2 transport system involving their extremely pH-sensitive haemoglobin (Hb. A reduction in pH reduces both Hb-O2 affinity (Bohr effect and carrying capacity (Root effect. This, combined with a large arterial-venous pH change (ΔpHa-v relative to other vertebrates, may greatly enhance tissue oxygen delivery in teleosts (e.g., rainbow trout during stress, beyond that in mammals (e.g., human. We generated oxygen equilibrium curves (OECs at five different CO2 tensions for rainbow trout and determined that, when Hb-O2 saturation is 50% or greater, the change in oxygen partial pressure (ΔPO2 associated with ΔpHa-v can exceed that of the mammalian Bohr effect by at least 3-fold, but as much as 21-fold. Using known ΔpHa-v and assuming a constant arterial-venous PO2 difference (Pa-vO2, Root effect Hbs can enhance O2 release to the tissues by 73.5% in trout; whereas, the Bohr effect alone is responsible for enhancing O2 release by only 1.3% in humans. Disequilibrium states are likely operational in teleosts in vivo, and therefore the ΔpHa-v, and thus enhancement of O2 delivery, could be even larger. Modeling with known Pa-vO2 in fish during exercise and hypoxia indicates that O2 release from the Hb and therefore potentially tissue O2 delivery may double during exercise and triple during some levels of hypoxia. These characteristics may be central to performance of athletic fish species such as salmonids, but may indicate that general tissue oxygen delivery may have been the incipient function of Root effect Hbs in fish, a trait strongly associated with the adaptive radiation of teleosts.

Simrank: Rapid and sensitive general-purpose k-mer search tool

Energy Technology Data Exchange (ETDEWEB)

DeSantis, T.Z.; Keller, K.; Karaoz, U.; Alekseyenko, A.V; Singh, N.N.S.; Brodie, E.L; Pei, Z.; Andersen, G.L; Larsen, N.

2011-04-01

Terabyte-scale collections of string-encoded data are expected from consortia efforts such as the Human Microbiome Project (http://nihroadmap.nih.gov/hmp). Intra- and inter-project data similarity searches are enabled by rapid k-mer matching strategies. Software applications for sequence database partitioning, guide tree estimation, molecular classification and alignment acceleration have benefited from embedded k-mer searches as sub-routines. However, a rapid, general-purpose, open-source, flexible, stand-alone k-mer tool has not been available. Here we present a stand-alone utility, Simrank, which allows users to rapidly identify database strings the most similar to query strings. Performance testing of Simrank and related tools against DNA, RNA, protein and human-languages found Simrank 10X to 928X faster depending on the dataset. Simrank provides molecular ecologists with a high-throughput, open source choice for comparing large sequence sets to find similarity.

INGEN: a general-purpose mesh generator for finite element codes

International Nuclear Information System (INIS)

Cook, W.A.

1979-05-01

INGEN is a general-purpose mesh generator for two- and three-dimensional finite element codes. The basic parts of the code are surface and three-dimensional region generators that use linear-blending interpolation formulas. These generators are based on an i, j, k index scheme that is used to number nodal points, construct elements, and develop displacement and traction boundary conditions. This code can generate truss elements (2 modal points); plane stress, plane strain, and axisymmetry two-dimensional continuum elements (4 to 8 nodal points); plate elements (4 to 8 nodal points); and three-dimensional continuum elements (8 to 21 nodal points). The traction loads generated are consistent with the element generated. The expansion--contraction option is of special interest. This option makes it possible to change an existing mesh such that some regions are refined and others are made coarser than the original mesh. 9 figures

A Real-Time Programmer's Tour of General-Purpose L4 Microkernels

Directory of Open Access Journals (Sweden)

Ruocco Sergio

2008-01-01

Full Text Available Abstract L4-embedded is a microkernel successfully deployed in mobile devices with soft real-time requirements. It now faces the challenges of tightly integrated systems, in which user interface, multimedia, OS, wireless protocols, and even software-defined radios must run on a single CPU. In this paper we discuss the pros and cons of L4-embedded for real-time systems design, focusing on the issues caused by the extreme speed optimisations it inherited from its general-purpose ancestors. Since these issues can be addressed with a minimal performance loss, we conclude that, overall, the design of real-time systems based on L4-embedded is possible, and facilitated by a number of design features unique to microkernels and the L4 family.

A low cost general purpose portable programmable master/slave manipulative appliance

International Nuclear Information System (INIS)

Cameron, W.

1984-01-01

The TRIUMF 100 μA 500 MeV cyclotron, located at the University of British Columbia, required a low cost, portable master/slave manipulative capability for experimental beam line servicing. A programmable capability was also required for the hot cell manipulators. A general purpose unit was developed that might also have applications in light manufacturing and medical rehabilitation. The project now in prototype testing represents a modular portable robot costing less than $5000 that is lead-through-teach programmable by either a master controller or hands-on lead-through. Task programs are stored and retrieved on any 32 k personal computer. An on-board proportional integral derivative controller (Motorola 6809 based) gives discrete positioning of the six degrees of freedom 2 kg capacity end effector

A Real-Time Programmer's Tour of General-Purpose L4 Microkernels

Directory of Open Access Journals (Sweden)

Sergio Ruocco

2008-02-01

Full Text Available L4-embedded is a microkernel successfully deployed in mobile devices with soft real-time requirements. It now faces the challenges of tightly integrated systems, in which user interface, multimedia, OS, wireless protocols, and even software-defined radios must run on a single CPU. In this paper we discuss the pros and cons of L4-embedded for real-time systems design, focusing on the issues caused by the extreme speed optimisations it inherited from its general-purpose ancestors. Since these issues can be addressed with a minimal performance loss, we conclude that, overall, the design of real-time systems based on L4-embedded is possible, and facilitated by a number of design features unique to microkernels and the L4 family.

BALTORO a general purpose code for coupling discrete ordinates and Monte-Carlo radiation transport calculations

International Nuclear Information System (INIS)

Zazula, J.M.

1983-01-01

The general purpose code BALTORO was written for coupling the three-dimensional Monte-Carlo /MC/ with the one-dimensional Discrete Ordinates /DO/ radiation transport calculations. The quantity of a radiation-induced /neutrons or gamma-rays/ nuclear effect or the score from a radiation-yielding nuclear effect can be analysed in this way. (author)

12 CFR 350.8 - Delivery.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Delivery. 350.8 Section 350.8 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY DISCLOSURE OF FINANCIAL AND OTHER INFORMATION BY FDIC-INSURED STATE NONMEMBER BANKS § 350.8 Delivery. Each bank shall, after...

Experience of application of the general-purpose pressure and pressure drop transformers on nitrogen tetroxide

International Nuclear Information System (INIS)

Grishchuk, M.Kh.

1979-01-01

An experience of application of the general-purpose pressure and pressure drop transformers at the Nuclear Power Engineering Institute of the BSSR Academy of Sciences for measurements on nitrogen tetroxide has been described. The concrete recommendations on the types of transformers and the volume of preparational work before putting them into operation have been given

Buccal Transmucosal Delivery System of Enalapril for Improved ...

African Journals Online (AJOL)

Purpose: To prepare and characterize buccal transmucosal delivery system of enalapril maleate for overcoming its low bioavailability, and hence provide improved therapeutic efficacy and patient compliance. Methods: Transmucosal drug delivery systems of enalapril maleate were formulated as buccal films by solvent ...

30 CFR 208.8 - Transportation and delivery.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Transportation and delivery. 208.8 Section 208... MANAGEMENT SALE OF FEDERAL ROYALTY OIL General Provisions § 208.8 Transportation and delivery. (a) The lessee... delivery point at no additional cost to the purchaser or the Government. The purchaser must have physical...

Performance Analysis of Cyber Security Awareness Delivery Methods

Science.gov (United States)

Abawajy, Jemal; Kim, Tai-Hoon

In order to decrease information security threats caused by human-related vulnerabilities, an increased concentration on information security awareness and training is necessary. There are numerous information security awareness training delivery methods. The purpose of this study was to determine what delivery method is most successful in providing security awareness training. We conducted security awareness training using various delivery methods such as text based, game based and a short video presentation with the aim of determining user preference delivery methods. Our study suggests that a combined delvery methods are better than individual secrity awareness delivery method.

General purpose graphics-processing-unit implementation of cosmological domain wall network evolution.

Science.gov (United States)

Correia, J R C C C; Martins, C J A P

2017-10-01

Topological defects unavoidably form at symmetry breaking phase transitions in the early universe. To probe the parameter space of theoretical models and set tighter experimental constraints (exploiting the recent advances in astrophysical observations), one requires more and more demanding simulations, and therefore more hardware resources and computation time. Improving the speed and efficiency of existing codes is essential. Here we present a general purpose graphics-processing-unit implementation of the canonical Press-Ryden-Spergel algorithm for the evolution of cosmological domain wall networks. This is ported to the Open Computing Language standard, and as a consequence significant speedups are achieved both in two-dimensional (2D) and 3D simulations.

General purpose graphics-processing-unit implementation of cosmological domain wall network evolution

Science.gov (United States)

Correia, J. R. C. C. C.; Martins, C. J. A. P.

2017-10-01

Topological defects unavoidably form at symmetry breaking phase transitions in the early universe. To probe the parameter space of theoretical models and set tighter experimental constraints (exploiting the recent advances in astrophysical observations), one requires more and more demanding simulations, and therefore more hardware resources and computation time. Improving the speed and efficiency of existing codes is essential. Here we present a general purpose graphics-processing-unit implementation of the canonical Press-Ryden-Spergel algorithm for the evolution of cosmological domain wall networks. This is ported to the Open Computing Language standard, and as a consequence significant speedups are achieved both in two-dimensional (2D) and 3D simulations.

DNA Processing and Reassembly on General Purpose FPGA-based Development Boards

Directory of Open Access Journals (Sweden)

SZÁSZ Csaba

2017-05-01

Full Text Available The great majority of researchers involved in microelectronics generally agree that many scientific challenges in life sciences have associated with them a powerful computational requirement that must be solved before scientific progress can be made. The current trend in Deoxyribonucleic Acid (DNA computing technologies is to develop special hardware platforms capable to provide the needed processing performance at lower cost. In this endeavor the FPGA-based (Field Programmable Gate Arrays configurations aimed to accelerate genome sequencing and reassembly plays a leading role. This paper emphasizes benefits and advantages using general purpose FPGA-based development boards in DNA reassembly applications beside the special hardware architecture solutions. An original approach is unfolded which outlines the versatility of high performance ready-to-use manufacturer development platforms endowed with powerful hardware resources fully optimized for high speed processing applications. The theoretical arguments are supported via an intuitive implementation example where the designer it is discharged from any hardware development effort and completely assisted in exclusive concentration only on software design issues providing greatly reduced application development cycles. The experiments prove that such boards available on the market are suitable to fulfill in all a wide range of DNA sequencing and reassembly applications.

Optimization of a truck-drone in tandem delivery network using K-means and genetic algorithm

OpenAIRE

Mourelo Ferrandez, Sergio; Harbison, Timothy; Webwer, Troy; Sturges, Robert; Rich, Robert

2016-01-01

Purpose: The purpose of this paper is to investigate the effectiveness of implementing unmanned aerial delivery vehicles in delivery networks. We investigate the notion of the reduced overall delivery time and energy for a truck-drone network by comparing the in-tandem system with a stand-alone delivery effort. The objectives are (1) to investigate the time and energy associated to a truck-drone delivery network compared to standalone truck or drone, (2) to propose an optimizat...

Literature Review: Weldability of Iridium DOP-26 Alloy for General Purpose Heat Source

Energy Technology Data Exchange (ETDEWEB)

Burgardt, Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pierce, Stanley W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-10-19

The basic purpose of this paper is to provide a literature review relative to fabrication of the General Purpose Heat Source (GPHS) that is used to provide electrical power for deep space missions of NASA. The particular fabrication operation to be addressed here is arc welding of the GPHS encapsulation. A considerable effort was made to optimize the fabrication of the fuel pellets and of other elements of the encapsulation; that work will not be directly addressed in this paper. This report consists of three basic sections: 1) a brief description of the GPHS will be provided as background information for the reader; 2) mechanical properties and the optimization thereof as relevant to welding will be discussed; 3) a review of the arc welding process development and optimization will be presented. Since the welding equipment must be upgraded for future production, some discussion of the historical establishment of relevant welding variables and possible changes thereto will also be discussed.

Design of tallying function for general purpose Monte Carlo particle transport code JMCT

International Nuclear Information System (INIS)

Shangguan Danhua; Li Gang; Deng Li; Zhang Baoyin

2013-01-01

A new postponed accumulation algorithm was proposed. Based on JCOGIN (J combinatorial geometry Monte Carlo transport infrastructure) framework and the postponed accumulation algorithm, the tallying function of the general purpose Monte Carlo neutron-photon transport code JMCT was improved markedly. JMCT gets a higher tallying efficiency than MCNP 4C by 28% for simple geometry model, and JMCT is faster than MCNP 4C by two orders of magnitude for complicated repeated structure model. The available ability of tallying function for JMCT makes firm foundation for reactor analysis and multi-step burnup calculation. (authors)

General-purpose heat source project and space nuclear safety and fuels program. Progress report

International Nuclear Information System (INIS)

Maraman, W.J.

1979-12-01

This formal monthly report covers the studies related to the use of 238 PuO 2 in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of the Los Alamos Scientific Laboratory. The two programs involved are general-purpose heat source development and space nuclear safety and fuels. Most of the studies discussed hear are of a continuing nature. Results and conclusions described may change as the work continues

Multi­-Threaded Algorithms for General purpose Graphics Processor Units in the ATLAS High Level Trigger

CERN Document Server

Conde Mui\\~no, Patricia; The ATLAS collaboration

2016-01-01

General purpose Graphics Processor Units (GPGPU) are being evaluated for possible future inclusion in an upgraded ATLAS High Level Trigger farm. We have developed a demonstrator including GPGPU implementations of Inner Detector and Muon tracking and Calorimeter clustering within the ATLAS software framework. ATLAS is a general purpose particle physics experiment located on the LHC collider at CERN. The ATLAS Trigger system consists of two levels, with level 1 implemented in hardware and the High Level Trigger implemented in software running on a farm of commodity CPU. The High Level Trigger reduces the trigger rate from the 100 kHz level 1 acceptance rate to 1 kHz for recording, requiring an average per­-event processing time of ~250 ms for this task. The selection in the high level trigger is based on reconstructing tracks in the Inner Detector and Muon Spectrometer and clusters of energy deposited in the Calorimeter. Performing this reconstruction within the available farm resources presents a significant ...

Operation of a general purpose stepping motor-encoder positioning subsystem at the National Synchrotron Light Source

International Nuclear Information System (INIS)

Stubblefield, F.W.

1985-11-01

Four copies of a general purpose subsystem for mechanical positioning of detectors, samples, and beam line optical elements which constitute experiments at the National Synchrotron Light Source facility of Brookhaven National Laboratory have been constructed and placed into operation. Construction of a fifth subsystem unit is nearing completion. The subsystems affect mechanical positioning by controlling a set of stepping motor-encoder pairs. The units are general purpose in the sense that they receive commands over a 9600 baud asynchronous serial line compatible with the RS-232-C electrical signal standard, generate TTL-compatible streams of stepping pulses which can be used with a wide variety of stepping motors, and read back position values from a number of different types and models of position encoder. The basic structure of the motor controller subsystem is briefly reviewed. Additions to the subsystem made in response to problems indicated by actual operation of the four installed units are described in more detail

Investigation of Factors Affecting Microdialysis Probe Delivery and ...

African Journals Online (AJOL)

Purpose: To investigate in vitro the factors affecting microdialysis probe delivery and recovery of puerarin. Methods: The recovery and delivery of puerarin were tested for extraction efficiency and retro-dialysis methods. Factors such as drug concentration, stirring speed, additives and length of membrane were studied to ...

Investigation of Factors Affecting Microdialysis Probe Delivery and ...

African Journals Online (AJOL)

Purpose: To investigate in vitro the factors affecting microdialysis probe delivery and recovery of puerarin . Methods: The recovery and delivery of puerarin were tested for extraction efficiency and retro-dialysis methods. Factors such as drug concentration, stirring speed, additives and length of membrane were studied to ...

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

Science.gov (United States)

Horvath, Dragos; Lisurek, Michael; Rupp, Bernd; Kühne, Ronald; Specker, Edgar; von Kries, Jens; Rognan, Didier; Andersson, C David; Almqvist, Fredrik; Elofsson, Mikael; Enqvist, Per-Anders; Gustavsson, Anna-Lena; Remez, Nikita; Mestres, Jordi; Marcou, Gilles; Varnek, Alexander; Hibert, Marcel; Quintana, Jordi; Frank, Ronald

2014-10-01

This work describes a collaborative effort to define and apply a protocol for the rational selection of a general-purpose screening library, to be used by the screening platforms affiliated with the EU-OPENSCREEN initiative. It is designed as a standard source of compounds for primary screening against novel biological targets, at the request of research partners. Given the general nature of the potential applications of this compound collection, the focus of the selection strategy lies on ensuring chemical stability, absence of reactive compounds, screening-compliant physicochemical properties, loose compliance to drug-likeness criteria (as drug design is a major, but not exclusive application), and maximal diversity/coverage of chemical space, aimed at providing hits for a wide spectrum of drugable targets. Finally, practical availability/cost issues cannot be avoided. The main goal of this publication is to inform potential future users of this library about its conception, sources, and characteristics. The outline of the selection procedure, notably of the filtering rules designed by a large committee of European medicinal chemists and chemoinformaticians, may be of general methodological interest for the screening/medicinal chemistry community. The selection task of 200K molecules out of a pre-filtered set of 1.4M candidates was shared by five independent European research groups, each picking a subset of 40K compounds according to their own in-house methodology and expertise. An in-depth analysis of chemical space coverage of the library serves not only to characterize the collection, but also to compare the various chemoinformatics-driven selection procedures of maximal diversity sets. Compound selections contributed by various participating groups were mapped onto general-purpose self-organizing maps (SOMs) built on the basis of marketed drugs and bioactive reference molecules. In this way, the occupancy of chemical space by the EU-OPENSCREEN library could

General purpose dynamic Monte Carlo with continuous energy for transient analysis

Energy Technology Data Exchange (ETDEWEB)

Sjenitzer, B. L.; Hoogenboom, J. E. [Delft Univ. of Technology, Dept. of Radiation, Radionuclide and Reactors, Mekelweg 15, 2629JB Delft (Netherlands)

2012-07-01

For safety assessments transient analysis is an important tool. It can predict maximum temperatures during regular reactor operation or during an accident scenario. Despite the fact that this kind of analysis is very important, the state of the art still uses rather crude methods, like diffusion theory and point-kinetics. For reference calculations it is preferable to use the Monte Carlo method. In this paper the dynamic Monte Carlo method is implemented in the general purpose Monte Carlo code Tripoli4. Also, the method is extended for use with continuous energy. The first results of Dynamic Tripoli demonstrate that this kind of calculation is indeed accurate and the results are achieved in a reasonable amount of time. With the method implemented in Tripoli it is now possible to do an exact transient calculation in arbitrary geometry. (authors)

Image-guided drug delivery: preclinical applications and clinical translation

NARCIS (Netherlands)

Ojha, Tarun; Rizzo, Larissa; Storm, Gerrit; Kiessling, Fabian; Lammers, Twan Gerardus Gertudis Maria

2015-01-01

Image-guided drug delivery refers to the combination of drug targeting and imaging. Preclinically, image-guided drug delivery can be used for several different purposes, including for monitoring biodistribution, target site accumulation, off-target localization, drug release and drug efficacy.

The U.S. Twin Delivery Volume and Association with Cesarean Delivery Rates: A Hospital-Level Analysis.

Science.gov (United States)

Easter, Sarah Rae; Robinson, Julian N; Carusi, Daniela; Little, Sarah E

2018-03-01

 The objective of this study was to test whether hospitals experienced in twin delivery have lower rates of cesarean delivery for twins.  We divided obstetric hospitals in the 2011 National Inpatient Sample by quartile of annual twin deliveries and compared twin cesarean delivery rates between hospitals with weighted linear regression. We used Pearson's coefficients to correlate a hospital's twin cesarean delivery rate to its overall cesarean delivery and vaginal birth after cesarean (VBAC) rates.  Annual twin delivery volume ranged from 1 to 506 across the 547 analyzed hospitals with a median of 10 and mode of 3. Adjusted rates of cesarean delivery were independent of delivery volume with a rate of 75.5 versus 74.8% in the lowest and highest volume hospitals ( p  = 0.09 across quartiles). A hospital's cesarean delivery rate for twins moderately correlated with the overall cesarean rate ( r  = 0.52, p  < 0.01) and inversely correlated with VBAC rate ( r  =  - 0.42, p  < 0.01).  Most U.S. obstetrical units perform a low volume of twin deliveries with no decrease in cesarean delivery rates at higher volume hospitals. Twin cesarean delivery rates correlate with other obstetric parameters such as singleton cesarean delivery and VBAC rates suggesting twin cesarean delivery rate is more closely related to a hospital's general obstetric practice than its twin delivery volume. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Measuring quality of delivery in a substance use prevention program.

Science.gov (United States)

Giles, Steven; Jackson-Newsom, Julia; Pankratz, Melinda M; Hansen, William B; Ringwalt, Christopher L; Dusenbury, Linda

2008-11-01

The purpose of this study was to develop and validate an observation measure designed to capture teachers' use of interactive teaching skills within the delivery of the All Stars substance use prevention program. Coders counted the number of times teachers praised and encouraged students, accepted and used students' ideas, asked questions, self-disclosed personal anecdotes, and corrected student misbehavior. These teacher behaviors loaded on three factors: classroom management, acknowledgment, and student-centered methods. Classroom management was negatively related to student engagement. Acknowledgment was negatively related to students' normative beliefs. Student-centered methods were positively related to student idealism and normative beliefs, and marginally predicted decreases in student marijuana use. Editors' Strategic Implications: The authors provide a promising approach to studying pedagogical prevention approaches, and they also link teaching processes to student outcomes. This study of program delivery should be of general interest (i.e., not limited to substance use prevention) to practitioners and researchers.

The democratisation of meal delivery service in France

OpenAIRE

Chen, Szu-Pu

2017-01-01

Master's thesis in International hotel and tourism management : Culinary leadership and innovation The purpose of this study was to explore the meal delivery service in French market and the customer’s opinion in the future meal delivery business. In addition, I first did the research basically on the evolution of history and the existing of delivery business in France. Then, I examined the dining habits and behaviours during the weekday of French citizen and their opinions in the futur...

Effects of Alternate Format In-Service Delivery on Teacher Knowledge Base and Problem-Solving Related to Autism & Adaptations: What Teachers Need to Know

Science.gov (United States)

Bruening, Marie Diane

2010-01-01

This study's purpose was to explore effectiveness of alternate format in-service delivery for what teachers needed to know to effectively teach their students with Autism Spectrum Disorder/High Functioning Autism/Asperger Syndrome (ASD/HFA/AS) in the general education setting. The study's research questions included: Did participants learn…

Evaluation of general-purpose collimators against high-resolution collimators with resolution recovery with a view to reducing radiation dose in myocardial perfusion SPECT: A preliminary phantom study.

Science.gov (United States)

Armstrong, Ian S; Saint, Kimberley J; Tonge, Christine M; Arumugam, Parthiban

2017-04-01

There is a growing focus on reducing radiation dose to patients undergoing myocardial perfusion imaging. This preliminary phantom study aims to evaluate the use of general-purpose collimators with resolution recovery (RR) to allow a reduction in patient radiation dose. Images of a cardiac torso phantom with inferior and anterior wall defects were acquired on a GE Infinia and Siemens Symbia T6 using both high-resolution and general-purpose collimators. Imaging time, a surrogate for administered activity, was reduced between 35% and 40% with general-purpose collimators to match the counts acquired with high-resolution collimators. Images were reconstructed with RR with and without attenuation correction. Two pixel sizes were also investigated. Defect contrast was measured. Defect contrast on general-purpose images was superior or comparable to the high-resolution collimators on both systems despite the reduced imaging time. Infinia general-purpose images required a smaller pixel size to be used to maintain defect contrast, while Symbia T6 general-purpose images did not require a change in pixel size to that used for standard myocardial perfusion SPECT. This study suggests that general-purpose collimators with RR offer a potential for substantial dose reductions while providing similar or better image quality to images acquired using high-resolution collimators.

Implementation of the dynamic Monte Carlo method for transient analysis in the general purpose code Tripoli

Energy Technology Data Exchange (ETDEWEB)

Sjenitzer, Bart L.; Hoogenboom, J. Eduard, E-mail: B.L.Sjenitzer@TUDelft.nl, E-mail: J.E.Hoogenboom@TUDelft.nl [Delft University of Technology (Netherlands)

2011-07-01

A new Dynamic Monte Carlo method is implemented in the general purpose Monte Carlo code Tripoli 4.6.1. With this new method incorporated, a general purpose code can be used for safety transient analysis, such as the movement of a control rod or in an accident scenario. To make the Tripoli code ready for calculating on dynamic systems, the Tripoli scheme had to be altered to incorporate time steps, to include the simulation of delayed neutron precursors and to simulate prompt neutron chains. The modified Tripoli code is tested on two sample cases, a steady-state system and a subcritical system and the resulting neutron fluxes behave just as expected. The steady-state calculation has a constant neutron flux over time and this result shows the stability of the calculation. The neutron flux stays constant with acceptable variance. This also shows that the starting conditions are determined correctly. The sub-critical case shows that the code can also handle dynamic systems with a varying neutron flux. (author)

Implementation of the dynamic Monte Carlo method for transient analysis in the general purpose code Tripoli

International Nuclear Information System (INIS)

Sjenitzer, Bart L.; Hoogenboom, J. Eduard

2011-01-01

A new Dynamic Monte Carlo method is implemented in the general purpose Monte Carlo code Tripoli 4.6.1. With this new method incorporated, a general purpose code can be used for safety transient analysis, such as the movement of a control rod or in an accident scenario. To make the Tripoli code ready for calculating on dynamic systems, the Tripoli scheme had to be altered to incorporate time steps, to include the simulation of delayed neutron precursors and to simulate prompt neutron chains. The modified Tripoli code is tested on two sample cases, a steady-state system and a subcritical system and the resulting neutron fluxes behave just as expected. The steady-state calculation has a constant neutron flux over time and this result shows the stability of the calculation. The neutron flux stays constant with acceptable variance. This also shows that the starting conditions are determined correctly. The sub-critical case shows that the code can also handle dynamic systems with a varying neutron flux. (author)

Edge corrections to electromagnetic Casimir energies from general-purpose Mathieu-function routines

Science.gov (United States)

Blose, Elizabeth Noelle; Ghimire, Biswash; Graham, Noah; Stratton-Smith, Jeremy

2015-01-01

Scattering theory methods make it possible to calculate the Casimir energy of a perfectly conducting elliptic cylinder opposite a perfectly conducting plane in terms of Mathieu functions. In the limit of zero radius, the elliptic cylinder becomes a finite-width strip, which allows for the study of edge effects. However, existing packages for computing Mathieu functions are insufficient for this calculation because none can compute Mathieu functions of both the first and second kind for complex arguments. To address this shortcoming, we have written a general-purpose Mathieu-function package, based on algorithms developed by Alhargan. We use these routines to find edge corrections to the proximity force approximation for the Casimir energy of a perfectly conducting strip opposite a perfectly conducting plane.

Advanced drug delivery systems: Nanotechnology of health design A review

Directory of Open Access Journals (Sweden)

Javad Safari

2014-04-01

Full Text Available Nanotechnology has finally and firmly entered the realm of drug delivery. Performances of intelligent drug delivery systems are continuously improved with the purpose to maximize therapeutic activity and to minimize undesirable side-effects. This review describes the advanced drug delivery systems based on micelles, polymeric nanoparticles, and dendrimers. Polymeric carbon nanotubes and many others demonstrate a broad variety of useful properties. This review emphasizes the main requirements for developing new nanotech-nology-based drug delivery systems.

How did the General Purpose Technology Electricity contribute to the Second Industrial Revolution (II): The Communication Engines

NARCIS (Netherlands)

van der Kooij, B.J.G.

2017-01-01

The concept of the General Purpose Technology (GPT) of the late 1990s is a culmination of many evolutionairy views in innovation-thinking. By definition the GPT considers the technical, social, and economic effects of meta-technologies like steam-technology and electric technology. This paper uses

42 CFR 67.10 - Purpose and scope.

Science.gov (United States)

2010-10-01

... and procedures; projects to improve methods and data bases for outcomes, effectiveness, and other... Research, Evaluation, Demonstration, and Dissemination Projects § 67.10 Purpose and scope. The regulations... projects, including conferences, on health care services and systems for the delivery of such services, as...

Interfacing a General Purpose Fluid Network Flow Program with the SINDA/G Thermal Analysis Program

Science.gov (United States)

Schallhorn, Paul; Popok, Daniel

1999-01-01

A general purpose, one dimensional fluid flow code is currently being interfaced with the thermal analysis program Systems Improved Numerical Differencing Analyzer/Gaski (SINDA/G). The flow code, Generalized Fluid System Simulation Program (GFSSP), is capable of analyzing steady state and transient flow in a complex network. The flow code is capable of modeling several physical phenomena including compressibility effects, phase changes, body forces (such as gravity and centrifugal) and mixture thermodynamics for multiple species. The addition of GFSSP to SINDA/G provides a significant improvement in convective heat transfer modeling for SINDA/G. The interface development is conducted in multiple phases. This paper describes the first phase of the interface which allows for steady and quasi-steady (unsteady solid, steady fluid) conjugate heat transfer modeling.

Amphiphilic block copolymers for drug delivery.

Science.gov (United States)

Adams, Monica L; Lavasanifar, Afsaneh; Kwon, Glen S

2003-07-01

Amphiphilic block copolymers (ABCs) have been used extensively in pharmaceutical applications ranging from sustained-release technologies to gene delivery. The utility of ABCs for delivery of therapeutic agents results from their unique chemical composition, which is characterized by a hydrophilic block that is chemically tethered to a hydrophobic block. In aqueous solution, polymeric micelles are formed via the association of ABCs into nanoscopic core/shell structures at or above the critical micelle concentration. Upon micellization, the hydrophobic core regions serve as reservoirs for hydrophobic drugs, which may be loaded by chemical, physical, or electrostatic means, depending on the specific functionalities of the core-forming block and the solubilizate. Although the Pluronics, composed of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), are the most widely studied ABC system, copolymers containing poly(L-amino acid) and poly(ester) hydrophobic blocks have also shown great promise in delivery applications. Because each ABC has unique advantages with respect to drug delivery, it may be possible to choose appropriate block copolymers for specific purposes, such as prolonging circulation time, introduction of targeting moieties, and modification of the drug-release profile. ABCs have been used for numerous pharmaceutical applications including drug solubilization/stabilization, alteration of the pharmacokinetic profile of encapsulated substances, and suppression of multidrug resistance. The purpose of this minireview is to provide a concise, yet detailed, introduction to the use of ABCs and polymeric micelles as delivery agents as well as to highlight current and past work in this area. Copyright 2003 Wiley-Liss, Inc. and the American Pharmacists Association

A General Purpose Feature Extractor for Light Detection and Ranging Data

Directory of Open Access Journals (Sweden)

Edwin B. Olson

2010-11-01

Full Text Available Feature extraction is a central step of processing Light Detection and Ranging (LIDAR data. Existing detectors tend to exploit characteristics of specific environments: corners and lines from indoor (rectilinear environments, and trees from outdoor environments. While these detectors work well in their intended environments, their performance in different environments can be poor. We describe a general purpose feature detector for both 2D and 3D LIDAR data that is applicable to virtually any environment. Our method adapts classic feature detection methods from the image processing literature, specifically the multi-scale Kanade-Tomasi corner detector. The resulting method is capable of identifying highly stable and repeatable features at a variety of spatial scales without knowledge of environment, and produces principled uncertainty estimates and corner descriptors at same time. We present results on both software simulation and standard datasets, including the 2D Victoria Park and Intel Research Center datasets, and the 3D MIT DARPA Urban Challenge dataset.

A general purpose feature extractor for light detection and ranging data.

Science.gov (United States)

Li, Yangming; Olson, Edwin B

2010-01-01

Feature extraction is a central step of processing Light Detection and Ranging (LIDAR) data. Existing detectors tend to exploit characteristics of specific environments: corners and lines from indoor (rectilinear) environments, and trees from outdoor environments. While these detectors work well in their intended environments, their performance in different environments can be poor. We describe a general purpose feature detector for both 2D and 3D LIDAR data that is applicable to virtually any environment. Our method adapts classic feature detection methods from the image processing literature, specifically the multi-scale Kanade-Tomasi corner detector. The resulting method is capable of identifying highly stable and repeatable features at a variety of spatial scales without knowledge of environment, and produces principled uncertainty estimates and corner descriptors at same time. We present results on both software simulation and standard datasets, including the 2D Victoria Park and Intel Research Center datasets, and the 3D MIT DARPA Urban Challenge dataset.

General purpose graphic processing unit implementation of adaptive pulse compression algorithms

Science.gov (United States)

Cai, Jingxiao; Zhang, Yan

2017-07-01

This study introduces a practical approach to implement real-time signal processing algorithms for general surveillance radar based on NVIDIA graphical processing units (GPUs). The pulse compression algorithms are implemented using compute unified device architecture (CUDA) libraries such as CUDA basic linear algebra subroutines and CUDA fast Fourier transform library, which are adopted from open source libraries and optimized for the NVIDIA GPUs. For more advanced, adaptive processing algorithms such as adaptive pulse compression, customized kernel optimization is needed and investigated. A statistical optimization approach is developed for this purpose without needing much knowledge of the physical configurations of the kernels. It was found that the kernel optimization approach can significantly improve the performance. Benchmark performance is compared with the CPU performance in terms of processing accelerations. The proposed implementation framework can be used in various radar systems including ground-based phased array radar, airborne sense and avoid radar, and aerospace surveillance radar.

Application of a general-purpose scintigraphic scanner to transverse-section (tomographic) gamma-ray imaging

International Nuclear Information System (INIS)

Bradstock, P.A.; Milward, R.C.

1976-01-01

The paper describes the recent application of a general-purpose commercial scintigraphic scanner to transverse-section radioisotope tomography. The principle of the method is to obtain the distribution of radioactive material in a thin transverse slice of the body or brain, from a mathematical reconstruction using the measured transverse projections of the activity within that slice. The usefulness of the radioisotope section-scanning technique for clinical diagnosis, as evidenced from one year's use of the machine at the Midland Centre for Neurology and Neurosurgery, Birmingham, U.K., is briefly discussed. (orig.) [de

Environmental assessment of general-purpose heat source safety verification testing

International Nuclear Information System (INIS)

1995-02-01

This Environmental Assessment (EA) was prepared to identify and evaluate potential environmental, safety, and health impacts associated with the Proposed Action to test General-Purpose Heat Source (GPHS) Radioisotope Thermoelectric Generator (RTG) assemblies at the Sandia National Laboratories (SNL) 10,000-Foot Sled Track Facility, Albuquerque, New Mexico. RTGs are used to provide a reliable source of electrical power on board some spacecraft when solar power is inadequate during long duration space missions. These units are designed to convert heat from the natural decay of radioisotope fuel into electrical power. Impact test data are required to support DOE's mission to provide radioisotope power systems to NASA and other user agencies. The proposed tests will expand the available safety database regarding RTG performance under postulated accident conditions. Direct observations and measurements of GPHS/RTG performance upon impact with hard, unyielding surfaces are required to verify model predictions and to ensure the continual evolution of the RTG designs that perform safely under varied accident environments. The Proposed Action is to conduct impact testing of RTG sections containing GPHS modules with simulated fuel. End-On and Side-On impact test series are planned

Computing OpenSURF on OpenCL and General Purpose GPU

Directory of Open Access Journals (Sweden)

Wanglong Yan

2013-10-01

Full Text Available Speeded-Up Robust Feature (SURF algorithm is widely used for image feature detecting and matching in computer vision area. Open Computing Language (OpenCL is a framework for writing programs that execute across heterogeneous platforms consisting of CPUs, GPUs, and other processors. This paper introduces how to implement an open-sourced SURF program, namely OpenSURF, on general purpose GPU by OpenCL, and discusses the optimizations in terms of the thread architectures and memory models in detail. Our final OpenCL implementation of OpenSURF is on average 37% and 64% faster than the OpenCV SURF v2.4.5 CUDA implementation on NVidia's GTX660 and GTX460SE GPUs, repectively. Our OpenCL program achieved real-time performance (>25 Frames Per Second for almost all the input images with different sizes from 320*240 to 1024*768 on NVidia's GTX660 GPU, NVidia's GTX460SE GPU and AMD's Radeon HD 6850 GPU. Our OpenCL approach on NVidia's GTX660 GPU is more than 22.8 times faster than its original CPU version on Intel's Dual-Core E5400 2.7G on average.

Second Generation Electronic Nicotine Delivery System Vape Pen Exposure Generalizes as a Smoking Cue.

Science.gov (United States)

King, Andrea C; Smith, Lia J; McNamara, Patrick J; Cao, Dingcai

2018-01-05

Second generation electronic nicotine delivery systems (ENDS; also known as e-cigarettes, vaporizers or vape pens) are designed for a customized nicotine delivery experience and have less resemblance to regular cigarettes than first generation "cigalikes." The present study examined whether they generalize as a conditioned cue and evoke smoking urges or behavior in persons exposed to their use. Data were analyzed in N = 108 young adult smokers (≥5 cigarettes per week) randomized to either a traditional combustible cigarette smoking cue or a second generation ENDS vaping cue in a controlled laboratory setting. Cigarette and e-cigarette urge and desire were assessed pre- and post-cue exposure. Smoking behavior was also explored in a subsample undergoing a smoking latency phase after cue exposure (N = 26). The ENDS vape pen cue evoked both urge and desire for a regular cigarette to a similar extent as that produced by the combustible cigarette cue. Both cues produced similar time to initiate smoking during the smoking latency phase. The ENDS vape pen cue elicited smoking urge and desire regardless of ENDS use history, that is, across ENDS naїve, lifetime or current users. Inclusion of past ENDS or cigarette use as covariates did not significantly alter the results. These findings demonstrate that observation of vape pen ENDS use generalizes as a conditioned cue to produce smoking urge, desire, and behavior in young adult smokers. As the popularity of these devices may eventually overtake those of first generation ENDS cigalikes, exposure effects will be of increasing importance. This study shows that passive exposure to a second generation ENDS vape pen cue evoked smoking urge, desire, and behavior across a range of daily and non-daily young adult smokers. Smoking urge and desire increases after vape pen exposure were similar to those produced by exposure to a first generation ENDS cigalike and a combustible cigarette, a known potent cue. Given the increasing

Drug delivery from the oral cavity: a focus on mucoadhesive buccal drug delivery systems.

Science.gov (United States)

Shinkar, Dattatraya Manohar; Dhake, Avinash Sridhar; Setty, Chitral Mallikarjuna

2012-01-01

Since the early 1980s the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. The various advantages associated with these systems made buccal drug delivery as a novel route of drug administration. It prolongs the residence time of the dosage form at the site of application. These systems remain in close contact with the absorption tissue, the mucous membrane, and thus contribute to improved and/or better therapeutic performance of the drug and of both local and systemic effects. This review highlights the anatomy and structure of oral mucosa, mechanism and theories of mucoadhesion, factors affecting mucoadhesion, characteristics and properties of desired mucoadhesive polymers, various types of dosage forms, and general considerations in design of mucoadhesive buccal dosage forms, permeation enhancers, and evaluation methods. Over the past few decades the mucoadhesive buccal drug delivery system has received a great deal of attention to develop mucoadhesive dosage forms to enable the prolonged retention at the site of action, providing a controlled release of drug for improved therapeutic outcome. Mucoadhesive drug delivery gives facility to include a permeation enhancer/enzyme inhibitor or pHmodifier in the formulation and versatility in designing as multidirectional or unidirectional release systems for local and systemic action. Local delivery to tissues of the oral cavity has a number of applications, including treatment of local conditions such as periodontal disease, bacterial and fungal infections, and aphthous stomatitis and vesiculo bullous diseases. For the treatment of chronic diseases, the mucoadhesive buccal drug delivery system allows easily accessibility and is generally well-accepted for administeringdrugs by systemic action.

7 CFR 249.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) General § 249.1 General.... 2011, et seq.), and to any other Federal or State food or nutrition assistance program under which...

Resistive-wall Wake Effect in the Beam Delivery System

International Nuclear Information System (INIS)

Delayen, J.R.; Jefferson Lab; Wu, Juhao; Raubenheimer, T.O.; SLAC; Wang, Jiunn-Ming; BNL, NSLS

2005-01-01

General formulae for resistive-wall induced beam dilution are presented and then applied to the final beam delivery system of linear colliders. Criteria for the design of final beam delivery systems are discussed

Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen

DEFF Research Database (Denmark)

Jain, Amit K; Thanki, Kaushik; Jain, Sanyog

2014-01-01

PURPOSE: The present work reports rationalized development and characterization of solidified self-nanoemulsifying drug delivery system for oral delivery of combinatorial (tamoxifen and quercetin) therapeutic regimen. METHODS: Suitable oil for the preparation of liquid SNEDDS was selected based...

A qualitative study of patient experiences of Type 2 Diabetes care delivered comparatively by General Practice Nurses and Medical Practitioners.

Science.gov (United States)

Boyle, Eileen; Saunders, Rosemary; Drury, Vicki

2016-07-01

To explore patient experiences of type 2 diabetes mellitus care delivered by general practice nurses in collaboration with the general practitioner. Australian general practice nurses are expanding their role in multidisciplinary type 2 diabetes care with limited research on patient perceptions of care provision within this collaborative model. Qualitative interpretive. Purposeful sampling was used to invite the patients (n = 10). Data were collected from semi-structured face-to-face interviews. Braun and Clarke's () inductive coding thematic analysis process was used to interpret the data. All participants experienced their General Practice Nurse consultation as a clinical assessment for their General Practitioner. While they appreciated the extra time with the General Practice Nurse, they were unsure of the purpose of the consultation beyond clinical assessment. They described the ongoing challenge of living with T2DM and identified a need for additional information and advice. The results suggest that the model of general practice nurse type 2 diabetes care has an important role to play in the delivery of effective ongoing care of patients. However, this role requires further development to ensure that it is understood by the patients as a role that not only conducts clinical assessments but also provides relevant education and self-management support as part of a collaborative approach to care delivery with General Practitioners. The findings are relevant to primary health care clinicians providing diabetes care to inform more relevant supportive care by general practice nurses. © 2016 John Wiley & Sons Ltd.

Controlling the delivery of outsourced services in asymmetrical supply chains

NARCIS (Netherlands)

Iwaarden, van J.; Valk, van der W.; Aalders, L.; Brown, S.W.

2009-01-01

Services are increasingly outsourced. When outsourced services are directly delivered to the final customer by the supplier, the buying company lacks direct control over the delivery of the service. The purpose of this study is to expand theory on control over service delivery in supply chains. A

Applications of polymeric nanocapsules in field of drug delivery systems.

Science.gov (United States)

Rong, Xinyu; Xie, Yinghua; Hao, Xiaomei; Chen, Tao; Wang, Yingming; Liu, Yuanyuan

2011-09-01

Drug-loaded polymeric nanocapsules have exhibited potential applications in the field of drug delivery systems in recent years. This article entails the biodegradable polymers generally used for preparing nanocapsules, which include both natural polymers and synthetic polymers. Furthermore, the article presents a general review of the different preparation methods: nanoprecipitation method, emulsion-diffusion method, double emulsification method, emulsion-coacervation method, layer-by-layer assembly method. In addition, the analysis methods of nanocapsule characteristics, such as mean size, morphology, surface characteristics, shell thickness, encapsulation efficiency, active substance release, dispersion stability, are mentioned. Also, the applications of nanocapsules as carriers for use in drug delivery systems are reviewed, which primarily involve targeting drug delivery, controlled/sustained release drug delivery systems, transdermal drug delivery systems and improving stability and bioavailability of drugs. Nanocapsules, prepared with different biodegradable polymers, have received more and more attention and have been regarded as one of the most promising drug delivery systems.

Design evolution and verification of the general-purpose heat source

International Nuclear Information System (INIS)

Schock, A.

The General-Purpose Heat Source (GPHS) is a radioisotope heat source for use in space power systems. It employs a modular design, to make it adaptable to a wide range of energy conversion systems and power levels. Each 250 W module is completely autonomous, with its own passive safety provisions to prevent fuel release under all abort modes, including atmospheric reentry and earth impact. Prior development tests had demonstrated good impact survival as long as the iridium fuel capsules retained their ductility. This requires high impact temperatures, typically above 900 0 C and reasonably fine grain size, which in turn requires avoidance of excessive operating temperatures and reentry temperatures. These three requirements - on operating, reentry, and impact temperatures - are in mutual conflict, since thermal design changes to improve any one of these temperatures tend to worsen one or both of the others. This conflict creates a difficult design problem, which for a time threatened the success of the program. The present paper describes how this problem was overcome by successive design revisions, supplemented by thermal analyses and confirmatory vibration and impact tests; and how this may be achieved while raising the specific power of the GPHS to 83 W/lb, a 50% improvement over previously flown radioisotope heat sources

TACO: a general-purpose tool for predicting cell-type-specific transcription factor dimers.

Science.gov (United States)

Jankowski, Aleksander; Prabhakar, Shyam; Tiuryn, Jerzy

2014-03-19

Cooperative binding of transcription factor (TF) dimers to DNA is increasingly recognized as a major contributor to binding specificity. However, it is likely that the set of known TF dimers is highly incomplete, given that they were discovered using ad hoc approaches, or through computational analyses of limited datasets. Here, we present TACO (Transcription factor Association from Complex Overrepresentation), a general-purpose standalone software tool that takes as input any genome-wide set of regulatory elements and predicts cell-type-specific TF dimers based on enrichment of motif complexes. TACO is the first tool that can accommodate motif complexes composed of overlapping motifs, a characteristic feature of many known TF dimers. Our method comprehensively outperforms existing tools when benchmarked on a reference set of 29 known dimers. We demonstrate the utility and consistency of TACO by applying it to 152 DNase-seq datasets and 94 ChIP-seq datasets. Based on these results, we uncover a general principle governing the structure of TF-TF-DNA ternary complexes, namely that the flexibility of the complex is correlated with, and most likely a consequence of, inter-motif spacing.

Low-cost general purpose spectral display unit using an IBM PC

International Nuclear Information System (INIS)

Robinson, S.L.

1985-10-01

Many physics experiments require acquisition and analysis of spectral data. commercial minicomputer-based multichannel analyzers collect detected counts at various energies, create a histogram of the counts in memory, and display the resultant spectra. They acquire data and provide the user-to-display interface. The system discussed separates functions into the three modular components of data acquisition, storage, and display. This decoupling of functions allows the experimenter to use any number of detectors for data collection before forwarding up to 64 spectra to the display unit, thereby increasing data throughput over that available with commercial systems. An IBM PC was chosen for the low-cost, general purpose display unit. Up to four spectra may be displayed simultaneously in different colors. The histogram saves 1024 channels per detector, 640 of which may be distinctly displayed per spectra. The IEEE-488 standard provides the data path between the IBM PC and the data collection unit. Data is sent to the PC under interrupt control, using direct memory access. Display manipulations available via keyboard are also discussed

Geometric correction of radiographic images using general purpose image processing program

International Nuclear Information System (INIS)

Kim, Eun Kyung; Cheong, Ji Seong; Lee, Sang Hoon

1994-01-01

The present study was undertaken to compare geometric corrected image by general-purpose image processing program for the Apple Macintosh II computer (NIH Image, Adobe Photoshop) with standardized image by individualized custom fabricated alignment instrument. Two non-standardized periapical films with XCP film holder only were taken at the lower molar portion of 19 volunteers. Two standardized periapical films with customized XCP film holder with impression material on the bite-block were taken for each person. Geometric correction was performed with Adobe Photoshop and NIH Image program. Specially, arbitrary image rotation function of 'Adobe Photoshop' and subtraction with transparency function of 'NIH Image' were utilized. The standard deviations of grey values of subtracted images were used to measure image similarity. Average standard deviation of grey values of subtracted images if standardized group was slightly lower than that of corrected group. However, the difference was found to be statistically insignificant (p>0.05). It is considered that we can use 'NIH Image' and 'Adobe Photoshop' program for correction of nonstandardized film, taken with XCP film holder at lower molar portion.

How did the General Purpose Technology ’Electricity’ contribute to the Second Industrial Revolution (I): The Power Engines.

NARCIS (Netherlands)

van der Kooij, B.J.G.

2016-01-01

The concept of the General Purpose Technology (GPT) of the late 1990s is a culmination of many evolutionairy views in innovation-thinking. By definition the GPT considers the technical, social, and economic effects of meta-technologies like steam-technology and electric technology. This paper uses

RUMD: A general purpose molecular dynamics package optimized to utilize GPU hardware down to a few thousand particles

DEFF Research Database (Denmark)

Bailey, Nicholas; Ingebrigtsen, Trond; Hansen, Jesper Schmidt

2017-01-01

RUMD is a general purpose, high-performance molecular dynamics (MD) simulation package running on graphical processing units (GPU’s). RUMD addresses the challenge of utilizing the many-core nature of modern GPU hardware when simulating small to medium system sizes (roughly from a few thousand up...

45 CFR 84.1 - Purpose.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Purpose. 84.1 Section 84.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 84.1 Purpose. The...

Assessment of mode of delivery and predictors of emergency caesarean section among women living with HIV in a matched-pair setting with women from the general population in Denmark, 2002-2014

DEFF Research Database (Denmark)

Ørbaek, M; Thorsteinsson, K; Helleberg, M

2017-01-01

OBJECTIVES: We aimed to assess mode of delivery and predictors of emergency caesarean section (EmCS) in women living with HIV (WLWH) in a matched-pair setting with women from the general population (WGP) in Denmark. Further, we analysed birth plan in WLWH. METHODS: All WLWH giving birth to live...... in the study. At delivery, all WLWH were on antiretroviral therapy and 85.6% had HIV RNA HIV-1 RNA copies/mL. Mean age was 32.7 years [95% confidence interval (CI) 32.1-33.2 years]. Mode of delivery differed significantly between WLWH and WGP [vaginal delivery, 33.4% versus 73.3%, respectively; elective...

Generic functional requirements for a NASA general-purpose data base management system

Science.gov (United States)

Lohman, G. M.

1981-01-01

Generic functional requirements for a general-purpose, multi-mission data base management system (DBMS) for application to remotely sensed scientific data bases are detailed. The motivation for utilizing DBMS technology in this environment is explained. The major requirements include: (1) a DBMS for scientific observational data; (2) a multi-mission capability; (3) user-friendly; (4) extensive and integrated information about data; (5) robust languages for defining data structures and formats; (6) scientific data types and structures; (7) flexible physical access mechanisms; (8) ways of representing spatial relationships; (9) a high level nonprocedural interactive query and data manipulation language; (10) data base maintenance utilities; (11) high rate input/output and large data volume storage; and adaptability to a distributed data base and/or data base machine configuration. Detailed functions are specified in a top-down hierarchic fashion. Implementation, performance, and support requirements are also given.

Design of the SLAC RCE Platform: A General Purpose ATCA Based Data Acquisition System

International Nuclear Information System (INIS)

Herbst, R.; Claus, R.; Freytag, M.; Haller, G.; Huffer, M.; Maldonado, S.; Nishimura, K.; O'Grady, C.; Panetta, J.; Perazzo, A.; Reese, B.; Ruckman, L.; Thayer, J.G.; Weaver, M.

2015-01-01

The SLAC RCE platform is a general purpose clustered data acquisition system implemented on a custom ATCA compliant blade, called the Cluster On Board (COB). The core of the system is the Reconfigurable Cluster Element (RCE), which is a system-on-chip design based upon the Xilinx Zynq family of FPGAs, mounted on custom COB daughter-boards. The Zynq architecture couples a dual core ARM Cortex A9 based processor with a high performance 28nm FPGA. The RCE has 12 external general purpose bi-directional high speed links, each supporting serial rates of up to 12Gbps. 8 RCE nodes are included on a COB, each with a 10Gbps connection to an on-board 24-port Ethernet switch integrated circuit. The COB is designed to be used with a standard full-mesh ATCA backplane allowing multiple RCE nodes to be tightly interconnected with minimal interconnect latency. Multiple shelves can be clustered using the front panel 10-gbps connections. The COB also supports local and inter-blade timing and trigger distribution. An experiment specific Rear Transition Module adapts the 96 high speed serial links to specific experiments and allows an experiment-specific timing and busy feedback connection. This coupling of processors with a high performance FPGA fabric in a low latency, multiple node cluster allows high speed data processing that can be easily adapted to any physics experiment. RTEMS and Linux are both ported to the module. The RCE has been used or is the baseline for several current and proposed experiments (LCLS, HPS, LSST, ATLAS-CSC, LBNE, DarkSide, ILC-SiD, etc).

Bilingual language control and general purpose cognitive control among individuals with bilingual aphasia: evidence based on negative priming and flanker tasks.

Science.gov (United States)

Dash, Tanya; Kar, Bhoomika R

2014-01-01

Bilingualism results in an added advantage with respect to cognitive control. The interaction between bilingual language control and general purpose cognitive control systems can also be understood by studying executive control among individuals with bilingual aphasia. objectives: The current study examined the subcomponents of cognitive control in bilingual aphasia. A case study approach was used to investigate whether cognitive control and language control are two separate systems and how factors related to bilingualism interact with control processes. Four individuals with bilingual aphasia performed a language background questionnaire, picture description task, and two experimental tasks (nonlinguistic negative priming task and linguistic and nonlinguistic versions of flanker task). A descriptive approach was used to analyse the data using reaction time and accuracy measures. The cumulative distribution function plots were used to visualize the variations in performance across conditions. The results highlight the distinction between general purpose cognitive control and bilingual language control mechanisms. All participants showed predominant use of the reactive control mechanism to compensate for the limited resources system. Independent yet interactive systems for bilingual language control and general purpose cognitive control were postulated based on the experimental data derived from individuals with bilingual aphasia.

Patient Involvement in Safe Delivery: A Qualitative Study

OpenAIRE

Olfati, Forozun; Asefzadeh, Saeid; Changizi, Nasrin; Keramat, Afsaneh; Yunesian, Masud

2015-01-01

Introduction: Patient involvement in safe delivery planning is considered important yet not widely practiced. The present study aimed at identifythe factors that affect patient involvementin safe delivery, as recommended by parturient women. Methods: This study was part of a qualitative research conducted by content analysis method and purposive sampling in 2013. The data were collected through 63 semi-structured interviews in4 hospitalsand analyzed using thematic content analysis. The partic...

Can Universities Profit from General Purpose Inventions?

DEFF Research Database (Denmark)

Barirani, Ahmad; Beaudry, Catherine; Agard, Bruno

2017-01-01

The lack of control over downstream assets can hinder universities’ ability to extract rents from their inventive activities. We explore this possibility by assessing the relationship between invention generality and renewal decisions for a sample of Canadian nanotechnology patents. Our results s...

Dosimetric verification of RapidArc treatment delivery

DEFF Research Database (Denmark)

Korreman, Stine; Medin, Joakim; Kjaer-Kristoffersen, Flemming

2009-01-01

. METHODS AND MATERIALS: Nine treatment plans were generated in the Eclipse version 8.5 including the RapidArc optimizer for H&N and prostate cases. The plans were delivered to the Scandidos Delta4 cylindrical diode array phantom. First, the measured dose distributions were compared with the calculated......: Overall, good agreement was observed between measured and calculated doses in most cases with gamma values above 1 in >95% of measured points. The reproducibility of delivery was also very high. Gamma analysis between two consecutive runs of the same delivery plan generally showed gamma values above 1......: The delivery of RapidArc beam delivery has been verified to correspond well with calculated dose distributions for a number of different cases. The delivery was very reproducible, and was carried out with high stability of the accelerator performance....

RoboCon: A general purpose telerobotic control center

Energy Technology Data Exchange (ETDEWEB)

Draper, J.V.; Noakes, M.W. [Oak Ridge National Lab., TN (United States). Robotics and Process Systems Div.; Schempf, H. [Carnegie Mellon Univ., Pittsburgh, PA (United States); Blair, L.M. [Human Machine Interfaces, Inc., Knoxville, TN (United States)

1997-02-01

This report describes human factors issues involved in the design of RoboCon, a multi-purpose control center for use in US Department of Energy remote handling applications. RoboCon is intended to be a flexible, modular control center capable of supporting a wide variety of robotic devices.

RoboCon: A general purpose telerobotic control center

International Nuclear Information System (INIS)

Draper, J.V.; Noakes, M.W.; Blair, L.M.

1997-01-01

This report describes human factors issues involved in the design of RoboCon, a multi-purpose control center for use in US Department of Energy remote handling applications. RoboCon is intended to be a flexible, modular control center capable of supporting a wide variety of robotic devices

Formulation and Evaluation of Two-Pulse Drug Delivery System of ...

African Journals Online (AJOL)

Purpose: To develop a pH-controlled two-pulse drug delivery system of amoxicillin in order to overcome ... delivery have lately been applied in developing a .... Note: Each tablet contained 2 mg each of magnesium stearate and colloidal silicon dioxide; total weight of each ..... and Manufacture of Medicines, 3rd edn, Elsevier,.

Mode of anaesthesia for preterm Caesarean delivery: secondary analysis from the Maternal-Fetal Medicine Units Network Caesarean Registry.

Science.gov (United States)

Butwick, A J; El-Sayed, Y Y; Blumenfeld, Y J; Osmundson, S S; Weiniger, C F

2015-08-01

Preterm delivery is often performed by Caesarean section. We investigated modes of anaesthesia and risk factors for general anaesthesia among women undergoing preterm Caesarean delivery. Women undergoing Caesarean delivery between 24(+0) and 36(+6) weeks' gestation were identified from a multicentre US registry. The mode of anaesthesia was classified as neuraxial anaesthesia (spinal, epidural, or combined spinal and epidural) or general anaesthesia. Logistic regression was used to identify patient characteristic, obstetric, and peripartum risk factors associated with general anaesthesia. Within the study cohort, 11 539 women had preterm Caesarean delivery; 9510 (82.4%) underwent neuraxial anaesthesia and 2029 (17.6%) general anaesthesia. In our multivariate model, African-American race [adjusted odds ratio (aOR)=1.9; 95% confidence interval (CI)=1.7-2.2], Hispanic ethnicity (aOR=1.5; 95% CI=1.2-1.8), other race (aOR=1.4; 95% CI=1.1-1.9), and haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome or eclampsia (aOR=2.8; 95% CI=2.2-3.5) were independently associated with receiving general anaesthesia for preterm Caesarean delivery. Women with an emergency Caesarean delivery indication had the highest odds for general anaesthesia (aOR=3.5; 95% CI=3.1-3.9). For every 1 week decrease in gestational age at delivery, the adjusted odds of general anaesthesia increased by 13%. In our study cohort, nearly one in five women received general anaesthesia for preterm Caesarean delivery. Although potential confounding by unmeasured factors cannot be excluded, our findings suggest that early gestational age at delivery, emergent Caesarean delivery indications, hypertensive disease, and non-Caucasian race or ethnicity are associated with general anaesthesia for preterm Caesarean delivery. © The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

''Sheiva'' : a general purpose multi-parameter data acquisition and processing system at VECC

International Nuclear Information System (INIS)

Viyogi, Y.P.; Ganguly, N.K.

1982-01-01

A general purpose interactive software to be used with the PDP-15/76 on-line computer at VEC Centre for the acquisition and processing of data in nuclear physics experiments is described. The program can accommodate a maximum of thirty two inputs although the present hardware limits the number of inputs to eight. Particular emphasis is given to the problems of flexibility and ease of operation, memory optimisation and techniques dealing with experimenter-computer interaction. Various graphical methods for one- and two-dimensional data presentation are discussed. Specific problems of particle identification using detector telescopes have been dealt with carefully to handle experiments using several detector telescopes and those involving light particle-heavy particle coincidence studies. Steps needed to tailor this program towards utilisation for special experiments are also described. (author)

Teaching English for Specific Purposes

Directory of Open Access Journals (Sweden)

Nijolė Netikšienė

2011-04-01

Full Text Available Teaching English for Specific Purposes and General English is analysed in the article. The scientific approach of a scientist M. Rosenberg is presented. The experience of teaching English for Specific Purposesat VGTU is alsopresented. The ideas and teaching methods from the classes of general English can be transferred to the classes of English for Specific Purposes.

The ICVSIE: A General Purpose Integral Equation Method for Bio-Electromagnetic Analysis.

Science.gov (United States)

Gomez, Luis J; Yucel, Abdulkadir C; Michielssen, Eric

2018-03-01

An internally combined volume surface integral equation (ICVSIE) for analyzing electromagnetic (EM) interactions with biological tissue and wide ranging diagnostic, therapeutic, and research applications, is proposed. The ICVSIE is a system of integral equations in terms of volume and surface equivalent currents in biological tissue subject to fields produced by externally or internally positioned devices. The system is created by using equivalence principles and solved numerically; the resulting current values are used to evaluate scattered and total electric fields, specific absorption rates, and related quantities. The validity, applicability, and efficiency of the ICVSIE are demonstrated by EM analysis of transcranial magnetic stimulation, magnetic resonance imaging, and neuromuscular electrical stimulation. Unlike previous integral equations, the ICVSIE is stable regardless of the electric permittivities of the tissue or frequency of operation, providing an application-agnostic computational framework for EM-biomedical analysis. Use of the general purpose and robust ICVSIE permits streamlining the development, deployment, and safety analysis of EM-biomedical technologies.

Drug delivery's quest for polymers: Where are the frontiers?

Science.gov (United States)

Merkle, Hans P

2015-11-01

Since the legendary 1964 article of Folkman and Long entitled "The use of silicone rubber as a carrier for prolonged drug therapy" the role of polymers in controlled drug delivery has come a long way. Today it is evident that polymers play a crucial if not the prime role in this field. The latest boost owes to the interest in drug delivery for the purpose of tissue engineering in regenerative medicine. The focus of this commentary is on a selection of general and personal observations that are characteristic for the current state of polymer therapeutics and carriers. It briefly highlights selected examples for the long march of synthetic polymer-drug conjugates from bench to bedside, comments on the ambivalence of selected polymers as inert excipients versus biological response modifiers, and on the yet unsolved dilemma of cationic polymers for the delivery of nucleic acid therapeutics. Further subjects are the complex design of multifunctional polymeric carriers including recent concepts towards functional supramolecular polymers, as well as observations on stimuli-sensitive polymers and the currently ongoing trend towards natural and naturally-derived biopolymers. The final topic is the discovery and early development of a novel type of biodegradable polyesters for parenteral use. Altogether, it is not the basic and applied research in polymer therapeutics and carriers, but the translational process that is the key hurdle to proceed towards an authoritative approval of new polymer therapeutics and carriers. Copyright © 2015 Elsevier B.V. All rights reserved.

12 CFR 41.1 - Purpose.

Science.gov (United States)

2010-01-01

... COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR CREDIT REPORTING General Provisions § 41.1 Purpose. (a) Purpose. The purpose of this part is to establish standards for national banks regarding consumer report information. In addition, the purpose of this part is to specify the extent to which...

Graduate Student Services: A Study of the Delivery of Services at the Location Where Students Matriculate

Science.gov (United States)

Burlison, John G.

2010-01-01

This dissertation investigates and explores the best method for the delivery of graduate student services. Essentially, there are two methods for delivery of these services. They can be delivered by virtue of centralization or decentralization. Decentralized delivery, for the purpose of this dissertation is the delivery of graduate student…

Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System

Science.gov (United States)

Zhou, Huafeng; Yue, Yang; Liu, Guanlan; Li, Yan; Zhang, Jing; Gong, Qiu; Yan, Zemin; Duan, Mingxing

2010-01-01

Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimental results demonstrated that an increasing concentration of soybean lecithin and glycerol resulted in a smaller size LNE droplet and increasing viscosity, respectively. The droplet size of optimized LNE, with the glycerol concentration above 75% (w/w), changed from 92 (F10) to 58 nm (F14). Additionally, LNE, incorporated into o/w cream, improved the skin hydration capacity of the cream significantly with about 2.5-fold increase when the concentration of LNE reached 10%. LNE was also demonstrated to improve the penetrability of Nile red (NR) dye into the dermis layer, when an o/w cream, incorporated with NR-loaded LNE, applied on the abdominal skin of rat in vivo. Specifically, the arbitrary unit (ABU) of fluorescence in the dermis layer that had received the cream with a NR-loaded LNE was about 9.9-fold higher than the cream with a NR-loaded general emulsion (GE). These observations suggest that LNE could be used as a promising topical delivery vehicle for lipophilic compounds.

Bilingual Language Control and General Purpose Cognitive Control among Individuals with Bilingual Aphasia: Evidence Based on Negative Priming and Flanker Tasks

Science.gov (United States)

Dash, Tanya; Kar, Bhoomika R.

2014-01-01

Background. Bilingualism results in an added advantage with respect to cognitive control. The interaction between bilingual language control and general purpose cognitive control systems can also be understood by studying executive control among individuals with bilingual aphasia. Objectives. The current study examined the subcomponents of cognitive control in bilingual aphasia. A case study approach was used to investigate whether cognitive control and language control are two separate systems and how factors related to bilingualism interact with control processes. Methods. Four individuals with bilingual aphasia performed a language background questionnaire, picture description task, and two experimental tasks (nonlinguistic negative priming task and linguistic and nonlinguistic versions of flanker task). Results. A descriptive approach was used to analyse the data using reaction time and accuracy measures. The cumulative distribution function plots were used to visualize the variations in performance across conditions. The results highlight the distinction between general purpose cognitive control and bilingual language control mechanisms. Conclusion. All participants showed predominant use of the reactive control mechanism to compensate for the limited resources system. Independent yet interactive systems for bilingual language control and general purpose cognitive control were postulated based on the experimental data derived from individuals with bilingual aphasia. PMID:24982591

A general purpose subroutine for fast fourier transform on a distributed memory parallel machine

Science.gov (United States)

Dubey, A.; Zubair, M.; Grosch, C. E.

1992-01-01

One issue which is central in developing a general purpose Fast Fourier Transform (FFT) subroutine on a distributed memory parallel machine is the data distribution. It is possible that different users would like to use the FFT routine with different data distributions. Thus, there is a need to design FFT schemes on distributed memory parallel machines which can support a variety of data distributions. An FFT implementation on a distributed memory parallel machine which works for a number of data distributions commonly encountered in scientific applications is presented. The problem of rearranging the data after computing the FFT is also addressed. The performance of the implementation on a distributed memory parallel machine Intel iPSC/860 is evaluated.

12 CFR 221.1 - Authority, purpose, and scope.

Science.gov (United States)

2010-01-01

... extend credit for the purpose of buying or carrying margin stock if the credit is secured directly or... Commodity Futures Trading Commission that accept deposits of margin stock in connection with: (i) The... for the purchase or sale of a commodity for future delivery or options on such contracts. (3) This...

General-purpose heat source project and space nuclear safety fuels program. Progress report, February 1980

International Nuclear Information System (INIS)

Maraman, W.J.

1980-05-01

This formal monthly report covers the studies related to the use of 238 PuO 2 in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of the Los Alamos Scientific Laboratory. The two programs involved are: General-Purpose Heat Source Development and Space Nuclear Safety and Fuels. Most of the studies discussed here are of a continuing nature. Results and conclusions described may change as the work continues. Published reference to the results cited in this report should not be made without the explicit permission of the person in charge of the work

Reduction of treatment delivery variances with a computer-controlled treatment delivery system

International Nuclear Information System (INIS)

Fraass, B.A.; Lash, K.L.; Matrone, G.M.; Lichter, A.S.

1997-01-01

Purpose: To analyze treatment delivery variances for 3-D conformal therapy performed at various levels of treatment delivery automation, ranging from manual field setup to virtually complete computer-controlled treatment delivery using a computer-controlled conformal radiotherapy system. Materials and Methods: All external beam treatments performed in our department during six months of 1996 were analyzed to study treatment delivery variances versus treatment complexity. Treatments for 505 patients (40,641 individual treatment ports) on four treatment machines were studied. All treatment variances noted by treatment therapists or quality assurance reviews (39 in all) were analyzed. Machines 'M1' (CLinac (6(100))) and 'M2' (CLinac 1800) were operated in a standard manual setup mode, with no record and verify system (R/V). Machines 'M3' (CLinac 2100CD/MLC) and ''M4'' (MM50 racetrack microtron system with MLC) treated patients under the control of a computer-controlled conformal radiotherapy system (CCRS) which 1) downloads the treatment delivery plan from the planning system, 2) performs some (or all) of the machine set-up and treatment delivery for each field, 3) monitors treatment delivery, 4) records all treatment parameters, and 5) notes exceptions to the electronically-prescribed plan. Complete external computer control is not available on M3, so it uses as many CCRS features as possible, while M4 operates completely under CCRS control and performs semi-automated and automated multi-segment intensity modulated treatments. Analysis of treatment complexity was based on numbers of fields, individual segments (ports), non-axial and non-coplanar plans, multi-segment intensity modulation, and pseudo-isocentric treatments (and other plans with computer-controlled table motions). Treatment delivery time was obtained from the computerized scheduling system (for manual treatments) or from CCRS system logs. Treatment therapists rotate among the machines, so this analysis

Screening tests in toxicity or drug effect studies with use of centrifichem general-purpose spectrophotometeric analyzer

International Nuclear Information System (INIS)

Nagy, B.; Bercz, J.P.

1986-01-01

CentrifiChem System 400 general-purpose spectrophotometric analyzer which can process simultaneously 30 samples and reads the reactions within milliseconds was used for toxicity studies. Organic and inorganic chemicals were screened for inhibitory action of the hydrolytic activity of sarcoplasmic reticulum (SR) Ca,Mg-ATPase and that of the sacrolemmal (SL) Na,K-ATPase, or mitochondrial ATPase (M). SR and SL were prepared from rabbit muscles, Na,K-ATPase from pig kidneys, M from pig hearts. Pseudosubstrates of paranitrophenyl phosphate and 2,4-dinitrophenyl phosphate, both proven high energy phosphate substitutes for ATPase coupled ion transfer were used. The reaction rates were followed spectrophotometrically at 405 nm measuring the accumulation of yellow nitrophenolate ions. The reported calcium transfer coupling ratio to hydrolysis of 2:1 was ascertained with use of 45 Ca in case of SR. Inhibition constants (pI) on SR, SL, and M for the pseudosubstrate hydrolysis will be given for over 20 chemicals tested. The applicability of the system to general toxicity testing and to general cardio-effective drug screening will be presented

Computer-controlled 3-D treatment delivery

International Nuclear Information System (INIS)

Fraass, Benedick A.

1995-01-01

Purpose/Objective: This course will describe the use of computer-controlled treatment delivery techniques for treatment of patients with sophisticated conformal therapy. In particular, research and implementation issues related to clinical use of computer-controlled conformal radiation therapy (CCRT) techniques will be discussed. The possible/potential advantages of CCRT techniques will be highlighted using results from clinical 3-D planning studies. Materials and Methods: In recent years, 3-D treatment planning has been used to develop and implement 3-D conformal therapy treatment techniques, and studies based on these conformal treatments have begun to show the promise of conformal therapy. This work has been followed by the development of commercially-available multileaf collimator and computer control systems for treatment machines. Using these (and other) CCRT devices, various centers are beginning to clinically use complex computer-controlled treatments. Both research and clinical CCRT treatment techniques will be discussed in this presentation. General concepts and requirements for CCRT will be mentioned. Developmental and clinical experience with CCRT techniques from a number of centers will be utilized. Results: Treatment planning, treatment preparation and treatment delivery must be approached in an integrated fashion in order to clinically implement CCRT treatment techniques, and the entire process will be discussed. Various CCRT treatment methodologies will be reviewed from operational, dosimetric, and technical points of view. The discussion will concentrate on CCRT techniques which are likely to see rather wide dissemination over the next several years, including particularly the use of multileaf collimators (MLC), dynamic and segmental conformal therapy, conformal field shaping, and other related techniques. More advanced CCRT techniques, such as the use of individualized intensity modulation of beams or segments, and the use of computer

General-purpose stepping motor-encoder positioning subsystem with standard asynchronous serial-line interface

International Nuclear Information System (INIS)

Stubblefield, F.W.; Alberi, J.L.

1982-01-01

A general-purpose mechanical positioning subsystem for open-loop control of experiment devices which have their positions established and read out by stepping motor-encoder combinations has been developed. The subsystem is to be used mainly for experiments to be conducted at the National Synchrotron Light Source at Brookhaven National Laboratory. The subsystem unit has been designed to be compatible with a wide variety of stepping motor and encoder types. The unit may be operated by any device capable of driving a standard RS-232-C asynchronous serial communication line. An informal survey has shown that several experiments at the Light Source will use one particular type of computer, operating system, and programming language. Accordingly, a library of subroutines compatible with this combination of computer system elements has been written to facilitate driving the positioning subsystem unit

General-purpose heat source safety verification test series: SVT-11 through SVT-13

International Nuclear Information System (INIS)

George, T.G.; Pavone, D.

1986-05-01

The General-Purpose Heat Source (GPHS) is a modular component of the radioisotope thermoelectric generator that will provide power for the Galileo and Ulysses (formerly ISPM) space missions. The GPHS provides power by transmitting the heat of 238 Pu α-decay to an array of thermoelectric elements. Because the possibility of an orbital abort always exists, the heat source was designed and constructed to minimize plutonia release in any accident environment. The Safety Verification Test (SVT) series was formulated to evaluate the effectiveness of GPHS plutonia containment after atmospheric reentry and Earth impact. The first two reports (covering SVT-1 through SVT-10) described the results of flat, side-on, and angular module impacts against steel targets at 54 m/s. This report describes flat-on module impacts against concrete and granite targets, at velocities equivalent to or higher than previous SVTs

General practitioner participation in intranatal care in the northern region in 1983.

OpenAIRE

Marsh, G N; Cashman, H A; Russell, I T

1985-01-01

In 1983 a quarter of general practitioners in the Northern region of England cared for obstetric deliveries and half of these for a minimum of 10 deliveries a year. Most expected their intranatal work to remain at the same level or increase in the next 10 years. Most participating general practitioners did their own forceps deliveries and initiated inductions. Most out of hours deliveries were attended by the mother's own general practitioner or a partner. A quarter of all respondents had car...

45 CFR 1170.1 - Purpose.

Science.gov (United States)

2010-10-01

... ACTIVITIES General Provisions § 1170.1 Purpose. The purpose of this part is to implement section 504 of the... 45 Public Welfare 3 2010-10-01 2010-10-01 false Purpose. 1170.1 Section 1170.1 Public Welfare... or activity receiving Federal financial assistance. ...

Modelling of a general purpose irradiation chamber using a Monte Carlo particle transport code

International Nuclear Information System (INIS)

Dhiyauddin Ahmad Fauzi; Sheik, F.O.A.; Nurul Fadzlin Hasbullah

2013-01-01

Full-text: The aim of this research is to stimulate the effectiveness use of a general purpose irradiation chamber to contain pure neutron particles obtained from a research reactor. The secondary neutron and gamma particles dose discharge from the chamber layers will be used as a platform to estimate the safe dimension of the chamber. The chamber, made up of layers of lead (Pb), shielding, polyethylene (PE), moderator and commercial grade aluminium (Al) cladding is proposed for the use of interacting samples with pure neutron particles in a nuclear reactor environment. The estimation was accomplished through simulation based on general Monte Carlo N-Particle transport code using Los Alamos MCNPX software. Simulations were performed on the model of the chamber subjected to high neutron flux radiation and its gamma radiation product. The model of neutron particle used is based on the neutron source found in PUSPATI TRIGA MARK II research reactor which holds a maximum flux value of 1 x 10 12 neutron/ cm 2 s. The expected outcomes of this research are zero gamma dose in the core of the chamber and neutron dose rate of less than 10 μSv/ day discharge from the chamber system. (author)

"Why Do I Have to Take This Course?": How Academic Advisers Can Help Students Find Personal Meaning and Purpose in General Education

Science.gov (United States)

Kirk-Kuwaye, Michael; Sano-Franchini, Dominic

2015-01-01

For a variety of reasons, student engagement in general education continues to be a challenge. Perhaps one way to increase engagement is to connect general education with a deep student need: finding meaning and purpose in their lives or exploring what some have called "big questions." Recent scholarship has defined these clusters of…

27 CFR 478.99 - Certain prohibited sales or deliveries.

Science.gov (United States)

2010-04-01

... political subdivision thereof; (2) For the purpose of exportation; or (3) For the purpose of testing or... any State or political subdivision thereof if a record of such ammunition is maintained in the form... delivery by a manufacturer or importer of such ammunition or 18 U.S.C. 929 relating to criminal misuse of...

Anesthetic management for cesarean delivery of a parturient with impetigo herpetiformis.

Science.gov (United States)

Duffield, Adrienne T; Smith, Kathleen A

2013-10-01

Impetigo herpetiformis (IH), or generalized pustular psoriasis of pregnancy, is an exceedingly rare, generalized pustular skin eruption occurring during pregnancy associated with hypovolemia, sepsis, hypocalcemia, and airway edema. Fetal outcomes are generally poor, and parturients with IH may present with emergent indications for cesarean delivery due to placental insufficiency. We present a case of IH in a 19-year-old G1P0 who underwent successful general anesthesia for cesarean delivery. Her case highlights the anesthetic implications for patients afflicted with this rare disease, including perioperative pain management, airway concerns, considerations for neuraxial anesthesia, and monitoring challenges.

45 CFR 2400.1 - Purposes.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purposes. 2400.1 Section 2400.1 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS General § 2400.1 Purposes. (a) The purposes of the James Madison Memorial Fellowship...

12 CFR 1805.100 - Purpose.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Purpose. 1805.100 Section 1805.100 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM General Provisions § 1805.100 Purpose. The purpose of the Community...

General Purpose Graphics Processing Unit Based High-Rate Rice Decompression and Reed-Solomon Decoding

Energy Technology Data Exchange (ETDEWEB)

Loughry, Thomas A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-02-01

As the volume of data acquired by space-based sensors increases, mission data compression/decompression and forward error correction code processing performance must likewise scale. This competency development effort was explored using the General Purpose Graphics Processing Unit (GPGPU) to accomplish high-rate Rice Decompression and high-rate Reed-Solomon (RS) decoding at the satellite mission ground station. Each algorithm was implemented and benchmarked on a single GPGPU. Distributed processing across one to four GPGPUs was also investigated. The results show that the GPGPU has considerable potential for performing satellite communication Data Signal Processing, with three times or better performance improvements and up to ten times reduction in cost over custom hardware, at least in the case of Rice Decompression and Reed-Solomon Decoding.

A General Purpose Connections type CTI Server Based on SIP Protocol and Its Implementation

Science.gov (United States)

Watanabe, Toru; Koizumi, Hisao

In this paper, we propose a general purpose connections type CTI (Computer Telephony Integration) server that provides various CTI services such as voice logging where the CTI server communicates with IP-PBX using the SIP (Session Initiation Protocol), and accumulates voice packets of external line telephone call flowing between an IP telephone for extension and a VoIP gateway connected to outside line networks. The CTI server realizes CTI services such as voice logging, telephone conference, or IVR (interactive voice response) with accumulating and processing voice packets sampled. Furthermore, the CTI server incorporates a web server function which can provide various CTI services such as a Web telephone directory via a Web browser to PCs, cellular telephones or smart-phones in mobile environments.

Technology and human purpose: the problem of solids transport on the Earth's surface

Science.gov (United States)

Haff, P. K.

2012-11-01

Displacement of mass of limited deformability ("solids") on the Earth's surface is opposed by friction and (the analog of) form resistance - impediments relaxed by rotational motion, self-powering of mass units, and transport infrastructure. These features of solids transport first evolved in the biosphere prior to the emergence of technology, allowing slope-independent, diffusion-like motion of discrete objects as massive as several tons, as illustrated by animal foraging and movement along game trails. However, high-energy-consumption technology powered by fossil fuels required a mechanism that could support fast advective transport of solids, i.e., long-distance, high-volume, high-speed, unidirectional, slope-independent transport across the land surface of materials like coal, containerized fluids, minerals, and economic goods. Pre-technology nature was able to sustain regional- and global-scale advection only in the limited form of piggybacking on geophysical flows of water (river sediment) and air (dust). The appearance of a mechanism for sustained advection of solids independent of fluid flows and gravity appeared only upon the emergence of human purpose. Purpose enables solids advection by, in effect, simulating a continuous potential gradient, otherwise lacking, between discrete and widely separated fossil-fuel energy sources and sinks. Invoking purpose as a mechanism in solids advection is an example of the need to import anthropic principles and concepts into the language and methodology of modern Earth system dynamics. As part of the emergence of a generalized solids advection mechanism, several additional transport requirements necessary to the function of modern large-scale technological systems were also satisfied. These include spatially accurate delivery of advected payload, targetability to essentially arbitrarily located destinations (such as cities), and independence of structure of advected payload from transport mechanism. The latter property

Applications of artificial intelligence to space station: General purpose intelligent sensor interface

Science.gov (United States)

Mckee, James W.

1988-01-01

This final report describes the accomplishments of the General Purpose Intelligent Sensor Interface task of the Applications of Artificial Intelligence to Space Station grant for the period from October 1, 1987 through September 30, 1988. Portions of the First Biannual Report not revised will not be included but only referenced. The goal is to develop an intelligent sensor system that will simplify the design and development of expert systems using sensors of the physical phenomena as a source of data. This research will concentrate on the integration of image processing sensors and voice processing sensors with a computer designed for expert system development. The result of this research will be the design and documentation of a system in which the user will not need to be an expert in such areas as image processing algorithms, local area networks, image processor hardware selection or interfacing, television camera selection, voice recognition hardware selection, or analog signal processing. The user will be able to access data from video or voice sensors through standard LISP statements without any need to know about the sensor hardware or software.

A low-cost general purpose spectral display unit using an IBM PC

International Nuclear Information System (INIS)

Robinson, S.L.

1986-01-01

Many physics experiments require acquisition and analysis of spectral data. Commercial minicomputer-based multichannel analyzers collect detected counts at various energies, create a histogram of the counts in memory, and display the resultant spectra. They acquire data and provide the user-to-display interface. The system discussed separates functions into the three modular components of data acquisition, storage, and display. This decoupling of functions allows the experimenter to use any number of detectors for data collection before forwarding up to 64 spectra to the display unit, thereby increasing data throughput over that available with commercial systems. An IBM PC was chosen for the low-cost, general purpose display unit. Up to four spectra may be displayed simultaneously in different colors. The histogram saves 1024 channels per detector, 640 of which may be distinctly displayed per spectra. The IEEE-488 standard provides the data path between the IBM PC and the data collection unit. Data is sent to the PC under interrupt control, using direct memory access. Display manipulations available via keyboard are also discussed

12 CFR 1806.100 - Purpose.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Purpose. 1806.100 Section 1806.100 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY BANK ENTERPRISE AWARD PROGRAM General Provisions § 1806.100 Purpose. The purpose of the Bank Enterprise Award Program is...

28 CFR 42.501 - Purpose.

Science.gov (United States)

2010-07-01

... the Rehabilitation Act of 1973 General Provisions § 42.501 Purpose. The purpose of this subpart is to... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Purpose. 42.501 Section 42.501 Judicial... basis of handicap in any program or activity receiving Federal financial assistance. ...

22 CFR 142.1 - Purpose.

Science.gov (United States)

2010-04-01

... RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 142.1 Purpose. The purpose of this part is to... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose. 142.1 Section 142.1 Foreign Relations... the basis of handicap in any program or activity receiving Federal financial assistance. ...

49 CFR 27.1 - Purpose.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Purpose. 27.1 Section 27.1 Transportation Office of the Secretary of Transportation NONDISCRIMINATION ON THE BASIS OF DISABILITY IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General § 27.1 Purpose. The purpose of this part is to...

GPScheDVS: A New Paradigm of the Autonomous CPU Speed Control for Commodity-OS-based General-Purpose Mobile Computers with a DVS-friendly Task Scheduling

OpenAIRE

Kim, Sookyoung

2008-01-01

This dissertation studies the problem of increasing battery life-time and reducing CPU heat dissipation without degrading system performance in commodity-OS-based general-purpose (GP) mobile computers using the dynamic voltage scaling (DVS) function of modern CPUs. The dissertation especially focuses on the impact of task scheduling on the effectiveness of DVS in achieving this goal. The task scheduling mechanism used in most contemporary general-purpose operating systems (GPOS) prioritizes t...

A general-purpose framework to simulate musculoskeletal system of human body: using a motion tracking approach.

Science.gov (United States)

Ehsani, Hossein; Rostami, Mostafa; Gudarzi, Mohammad

2016-02-01

Computation of muscle force patterns that produce specified movements of muscle-actuated dynamic models is an important and challenging problem. This problem is an undetermined one, and then a proper optimization is required to calculate muscle forces. The purpose of this paper is to develop a general model for calculating all muscle activation and force patterns in an arbitrary human body movement. For this aim, the equations of a multibody system forward dynamics, which is considered for skeletal system of the human body model, is derived using Lagrange-Euler formulation. Next, muscle contraction dynamics is added to this model and forward dynamics of an arbitrary musculoskeletal system is obtained. For optimization purpose, the obtained model is used in computed muscle control algorithm, and a closed-loop system for tracking desired motions is derived. Finally, a popular sport exercise, biceps curl, is simulated by using this algorithm and the validity of the obtained results is evaluated via EMG signals.

[Delivery of the IUGR fetus].

Science.gov (United States)

Perrotin, F; Simon, E G; Potin, J; Laffon, M

2013-12-01

The purpose of this paper is to review available data regarding the management of delivery in intra uterine growth retarded fetuses and try to get recommendations for clinical obstetrical practice. Bibliographic research performed by consulting PubMed database and recommendations from scientific societies with the following words: small for gestational age, intra-uterine growth restriction, fetal growth restriction, very low birth weight infants, as well as mode of delivery, induction of labor, cesarean section and operative delivery. The diagnosis of severe IUGR justifies the orientation of the patient to a referral centre with all necessary resources for very low birth weight or premature infants Administration of corticosteroids for fetal maturation (before 34 WG) and a possible neuroprotective treatment by with magnesium sulphate (before 32-33 WG) should be discussed. Although elective caesarean section is common, there is no current evidence supporting the use of systematic cesarean section, especially when the woman is in labor. Induction of labor, even with unfavorable cervix is possible under continuous FHR monitoring, in favorable obstetric situations and in the absence of severe fetal hemodynamic disturbances. Instrumental delivery and routine episiotomy are not recommended. For caesarean section under spinal anesthesia, an adequate anesthetic management must ensure the maintenance of basal blood pressure. Compared with appropriate for gestational age fetus, IUGR fetus is at increased risk of metabolic acidosis or perinatal asphyxia during delivery. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles.

NARCIS (Netherlands)

Fokong, S.; Theek, B.; Koczera, P.; Appold, L.; Resch-Genger, U.; van Zandvoort, M.; Storm, Gerrit; Kiessling, F.; Lammers, Twan Gerardus Gertudis Maria

2012-01-01

Abstract Microbubbles (MB) are routinely used contrast agents for functional and molecular ultrasound (US) imaging. In addition, they have been attracting more and more attention for drug delivery purposes, enabling e.g. US-mediated drug delivery across biological barriers and US-induced triggered

Multi-Course Comparison of Traditional versus Web-Based Course Delivery Systems

Science.gov (United States)

Weber, J. Michael; Lennon, Ron

2007-01-01

The purpose of this paper is to measure and compare the effectiveness of a Web-based course delivery system to a traditional course delivery system. The results indicate that a web-based course is effective and equivalent to a traditional classroom environment. As with the implementation of all new technologies, there are some pros and cons that…

Low-activity waste feed delivery -- Minimum duration between successive batches

International Nuclear Information System (INIS)

Peters, B.B.

1998-01-01

The purpose of this study is to develop a defensible basis for establishing what ''minimum duration'' will provide acceptable risk mitigation for low-activity waste feed delivery to the privatization vendors. The study establishes a probabilistic-based duration for staging of low-activity waste feed batches. A comparison is made of the durations with current feed delivery plans and potential privatization vendor facility throughput rates

Low-activity waste feed delivery -- Minimum duration between successive batches

Energy Technology Data Exchange (ETDEWEB)

Peters, B.B.

1998-08-25

The purpose of this study is to develop a defensible basis for establishing what ``minimum duration`` will provide acceptable risk mitigation for low-activity waste feed delivery to the privatization vendors. The study establishes a probabilistic-based duration for staging of low-activity waste feed batches. A comparison is made of the durations with current feed delivery plans and potential privatization vendor facility throughput rates.

Nanocarriers in ocular drug delivery: an update review.

Science.gov (United States)

Wadhwa, Sheetu; Paliwal, Rishi; Paliwal, Shivani Rai; Vyas, S P

2009-01-01

Controlled drug delivery to eye is one of the most challenging fields of pharmaceutical research. Low drug-contact time and poor ocular bioavailability due to drainage of solution, tear turnover and its dilution or lacrimation are the problems associated with conventional systems. In addition, anatomical barriers and physiological conditions of eye are also important parameters which control designing of drug delivery systems. Nanosized carriers like micro/nano-suspensions, liposome, niosome, dendrimer, nanoparticles, ocular inserts, implants, hydrogels and prodrug approaches have been developed for this purpose. These novel systems offer manifold advantages over conventional systems as they increase the efficiency of drug delivery by improving the release profile and also reduce drug toxicity. Conventional delivery systems get diluted with tear, washed away through the lacrimal gland and usually require administering at regular time intervals whereas nanocarriers release drug at constant rate for a prolonged period of time and thus enhance its absorption and site specific delivery. This review presents an overview of the various aspects of the ocular drug delivery, with special emphasis on nanocarrier based strategies, including structure of eye, its barriers, delivery routes and the challenges/limitations associated with development of novel nanocarriers. The recent progresses in therapy of ocular disease like gene therapy have also been included so that future options should also be considered from the delivery point of view. Recent progress in the delivery of proteins and peptides via ocular route has also been incorporated for reader benefit.

45 CFR 605.1 - Purpose.

Science.gov (United States)

2010-10-01

... OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 605.1 Purpose. The purpose of this part is to effectuate section 504 of the Rehabilitation Act of 1973... 45 Public Welfare 3 2010-10-01 2010-10-01 false Purpose. 605.1 Section 605.1 Public Welfare...

49 CFR 604.1 - Purpose.

Science.gov (United States)

2010-10-01

... TRANSPORTATION CHARTER SERVICE General provisions. § 604.1 Purpose. (a) The purpose of this part is to implement... 49 Transportation 7 2010-10-01 2010-10-01 false Purpose. 604.1 Section 604.1 Transportation Other... recipients of Federal financial assistance under the Federal Transit Laws. (b) This subpart specifies which...

Intranasal delivery of antiviral siRNA.

Science.gov (United States)

Barik, Sailen

2011-01-01

Intranasal administration of synthetic siRNA is an effective modality of RNAi delivery for the prevention and therapy of respiratory diseases, including pulmonary infections. Vehicles used for nasal siRNA delivery include established as well as novel reagents, many of which have been recently optimized. In general, they all promote significant uptake of siRNA into the lower respiratory tract, including the lung. When properly designed and optimized, these siRNAs offer significant protection against respiratory viruses such as influenza virus, parainfluenza virus and respiratory syncytial virus (RSV). Nasally administered siRNA remains within the lung and does not access systemic blood flow, as judged by its absence in other major organs such as liver, heart, kidney, and skeletal muscle. Adverse immune reaction is generally not encountered, especially when immunogenic and/or off-target siRNA sequences and toxic vehicles are avoided. In fact, siRNA against RSV has entered Phase II clinical trials in human with promising results. Here, we provide a standardized procedure for using the nose as a specific route for siRNA delivery into the lung of laboratory animals. It should be clear that this simple and efficient system has enormous potential for therapeutics.

5 CFR 582.101 - Purpose.

Science.gov (United States)

2010-01-01

... of the United States Postal Service, the Postal Rate Commission, and the General Accounting Office. ... FEDERAL EMPLOYEES' PAY Purpose, Definitions, and Exclusions § 582.101 Purpose. Section 5520a of title 5 of...

Assessment of general public perceptions toward traditional medicines used for aphrodisiac purpose in state of Penang, Malaysia.

Science.gov (United States)

Hassali, Mohamed Azmi; Saleem, Fahad; Shafie, Asrul Akmal; Al-Qazaz, Harith Khalid; Farooqui, Maryam; Aljadhey, Hisham; Atif, Muhammad; Masood, Imran

2012-11-01

The study aims to evaluate general public perceptions regarding the use of Traditional and Complementary Medicines (TCM) for aphrodisiac purposes. A questionnaire based, cross-sectional study was undertaken. Respondents were selected in the state of Penang, Malaysia. A total of 392 respondents were included in the study. Descriptive statistics were used for data analysis. Chi Square/Fischer Exact tests were used where appropriate. Out of 392 respondents, 150 (38.26%) reported using specific Traditional medicines for aphrodisiac purposes. Most respondents (46.94%) agreed that aphrodisiac medicines were easily available t. Moreover, 40.31% of the respondents reported that traditional aphrodisiac medicines were cheaper than modern (prescription) medicines. This study highlights limited public knowledge regarding the use of traditional aphrodisiac medicine. Healthcare professionals should be aware of informal TCM usage when prescribing allopathic medicines. Copyright © 2012 Elsevier Ltd. All rights reserved.

Providing assistive technology in Italy : The perceived delivery process quality as affecting abandonment

NARCIS (Netherlands)

Federici, Stefano; Borsci, Simone

2016-01-01

Purpose: The study brings together three aspects rarely observed at once in assistive technology (AT) surveys: (i) the assessment of user interaction/satisfaction with AT and service delivery, (ii) the motivational analysis of AT abandonment, and (iii) the management/design evaluation of AT delivery

23 CFR 710.101 - Purpose.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Purpose. 710.101 Section 710.101 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT RIGHT-OF-WAY AND REAL ESTATE General § 710.101 Purpose. The primary purpose of the requirements in this part is to ensure the...

34 CFR 104.1 - Purpose.

Science.gov (United States)

2010-07-01

... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 104.1 Purpose. The purpose of this part is to effectuate section 504 of the Rehabilitation Act... 34 Education 1 2010-07-01 2010-07-01 false Purpose. 104.1 Section 104.1 Education Regulations of...

45 CFR 1232.1 - Purpose.

Science.gov (United States)

2010-10-01

... NONDISCRIMINATION ON BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 1232.1 Purpose. The purpose of this part is to effectuate section 504 of the Rehabilitation Act... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purpose. 1232.1 Section 1232.1 Public Welfare...

33 CFR 135.101 - Purpose.

Science.gov (United States)

2010-07-01

... FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Levy of Fees § 135.101 Purpose. (a) The purpose of this subpart is to state the general requirements concerning the levy of fees. ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Purpose. 135.101 Section 135.101...

49 CFR 22.1 - Purpose.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Purpose. 22.1 Section 22.1 Transportation Office of the Secretary of Transportation SHORT-TERM LENDING PROGRAM (STLP) General § 22.1 Purpose. The purpose of the DOT OSDBU STLP is to provide financial assistance in the form of short-term loans from...

22 CFR 217.1 - Purpose.

Science.gov (United States)

2010-04-01

... RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 217.1 Purpose. The purpose of this part is to... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose. 217.1 Section 217.1 Foreign Relations... the basis of handicap in any program or activity within the United States receiving Federal financial...

7 CFR 210.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... general and special cash assistance and donations of foods acquired by the Department to be used to assist..., preparation and service of nutritious lunches, payment of funds, use of program funds, program monitoring, and...

Improvement of arbutin trans-epidermal delivery using ...

African Journals Online (AJOL)

Purpose: To assess the ability of radiofrequency (RF) microporation to promote trans-epidermal delivery of arbutin. Methods: To investigate the enhancing effect of RF microchannels on skin permeation of arbutin, in vitro skin permeability studies were performed with RF microporation-treated Hartley albino guinea pig skin ...

12 CFR 408.2 - Purpose.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Purpose. 408.2 Section 408.2 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES PROCEDURES FOR COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT General § 408.2 Purpose. The purpose of this part is to establish procedures which supplement the...

29 CFR 32.1 - Purpose.

Science.gov (United States)

2010-07-01

... ASSISTANCE General Provisions § 32.1 Purpose. Section 504 of the Rehabilitation Act of 1973 prohibits... purpose of this part is to implement section 504 with respect to receiving Federal financial assistance... 29 Labor 1 2010-07-01 2010-07-01 true Purpose. 32.1 Section 32.1 Labor Office of the Secretary of...

24 CFR 963.1 - Purpose.

Science.gov (United States)

2010-04-01

... by this part is based on the established procurement procedures set forth in 24 CFR 85.36, with... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Purpose. 963.1 Section 963.1... HOUSING-CONTRACTING WITH RESIDENT-OWNED BUSINESSES General § 963.1 Purpose. The purpose of this part is to...

A real-time virtual delivery system for photon radiotherapy delivery monitoring

Directory of Open Access Journals (Sweden)

Feng Shi

2014-03-01

Full Text Available Purpose: Treatment delivery monitoring is important for radiotherapy, which enables catching dosimetric error at the earliest possible opportunity. This project develops a virtual delivery system to monitor the dose delivery process of photon radiotherapy in real-time using GPU-based Monte Carlo (MC method.Methods: The simulation process consists of 3 parallel CPU threads. A thread T1 is responsible for communication with a linac, which acquires a set of linac status parameters, e.g. gantry angles, MLC configurations, and beam MUs every 20 ms. Since linac vendors currently do not offer interface to acquire data in real time, we mimic this process by fetching information from a linac dynalog file at the set frequency. Instantaneous beam fluence map (FM is calculated based. A FM buffer is also created in T1 and the instantaneous FM is accumulated to it. This process continues, until a ready signal is received from thread T2 on which an in-house developed MC dose engine executes on GPU. At that moment, the accumulated FM is transferred to T2 for dose calculations, and the FM buffer in T1 is cleared. Once the dose calculation finishes, the resulting 3D dose distribution is directed to thread T3, which displays it in three orthogonal planes in color wash overlaid on the CT image. This process continues to monitor the 3D dose distribution in real-time.Results: An IMRT and a VMAT cases used in our patient-specific QA are studied. Maximum dose differences between our system and treatment planning system are 0.98% and 1.58% for the IMRT and VMAT cases, respectively. The update frequency is >10Hz and the relative uncertainty level is 2%.Conclusion: By embedding a GPU-based MC code in a novel data/work flow, it is possible to achieve real-time MC dose calculations to monitor delivery process.------------------------------Cite this article as: Shi F, Gu X, Graves YJ, Jiang S, Jia X. A real-time virtual delivery system for photon radiotherapy delivery

Advancement in integrin facilitated drug delivery.

Science.gov (United States)

Arosio, Daniela; Casagrande, Cesare

2016-02-01

The research of integrin-targeted anticancer agents has recorded important advancements in ingenious design of delivery systems, based either on the prodrug approach, or on nanoparticle carriers, but for now, none of these has reached a clinical stage of development. Past work in this area has been extensively reviewed by us and others. Thus, the purpose and scope of the present review is to survey the advancement reported in the last 3years, with focus on innovative delivery systems that appear to afford openings for future developments. These systems exploit the labelling with conventional and novel integrin ligands for targeting the interface of cancer cells and of endothelial cells involved in cancer angiogenesis, with the proteins of the extracellular matrix, in the circulation, in tissues, and in tumour stroma, as the site of progression and metastatic evolution of the disease. Furthermore, these systems implement the expertise in the development of nanomedicines to the purpose of achieving preferential biodistribution and uptake in cancer tissues, internalisation in cancer cells, and release of the transported drugs at intracellular sites. The assessment of the value of controlling these factors, and their combination, for future developments requires support of biological testing in appropriate mechanistic models, but also imperatively demand confirmation in therapeutically relevant in vivo models for biodistribution, efficacy, and lack of off-target effects. Thus, among many studies, we have tried to point out the results supported by relevant in vivo studies, and we have emphasised in specific sections those addressing the medical needs of drug delivery to brain tumours, as well as the delivery of oligonucleotides modulating gene-dependent pathological mechanism. The latter could constitute the basis of a promising third branch in the therapeutic armamentarium against cancer, in addition to antibody-based agents and to cytotoxic agents. Copyright © 2015

Transforming the ASDEX Upgrade discharge control system to a general-purpose plasma control platform

International Nuclear Information System (INIS)

Treutterer, Wolfgang; Cole, Richard; Gräter, Alexander; Lüddecke, Klaus; Neu, Gregor; Rapson, Christopher; Raupp, Gerhard; Zasche, Dieter; Zehetbauer, Thomas

2015-01-01

Highlights: • Control framework split in core and custom part. • Core framework deployable in other fusion device environments. • Adaptible through customizable modules, plug-in support and generic interfaces. - Abstract: The ASDEX Upgrade Discharge Control System DCS is a modern and mature product, originally designed to regulate and supervise ASDEX Upgrade Tokamak plasma operation. In its core DCS is based on a generic, versatile real-time software framework with a plugin architecture that allows to easily combine, modify and extend control function modules in order to tailor the system to required features and let it continuously evolve with the progress of an experimental fusion device. Due to these properties other fusion experiments like the WEST project have expressed interest in adopting DCS. For this purpose, essential parts of DCS must be unpinned from the ASDEX Upgrade environment by exposure or introduction of generalised interfaces. Re-organisation of DCS modules allows distinguishing between intrinsic framework core functions and device-specific applications. In particular, DCS must be prepared for deployment in different system environments with their own realisations for user interface, pulse schedule preparation, parameter server, time and event distribution, diagnostic and actuator systems, network communication and data archiving. The article explains the principles of the revised DCS structure, derives the necessary interface definitions and describes major steps to achieve the separation between general-purpose framework and fusion device specific components.

Transforming the ASDEX Upgrade discharge control system to a general-purpose plasma control platform

Energy Technology Data Exchange (ETDEWEB)

Treutterer, Wolfgang, E-mail: Wolfgang.Treutterer@ipp.mpg.de [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Cole, Richard [Unlimited Computer Systems, Seeshaupter Str. 15, 82393 Iffeldorf (Germany); Gräter, Alexander [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Lüddecke, Klaus [Unlimited Computer Systems, Seeshaupter Str. 15, 82393 Iffeldorf (Germany); Neu, Gregor; Rapson, Christopher; Raupp, Gerhard; Zasche, Dieter; Zehetbauer, Thomas [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany)

2015-10-15

Highlights: • Control framework split in core and custom part. • Core framework deployable in other fusion device environments. • Adaptible through customizable modules, plug-in support and generic interfaces. - Abstract: The ASDEX Upgrade Discharge Control System DCS is a modern and mature product, originally designed to regulate and supervise ASDEX Upgrade Tokamak plasma operation. In its core DCS is based on a generic, versatile real-time software framework with a plugin architecture that allows to easily combine, modify and extend control function modules in order to tailor the system to required features and let it continuously evolve with the progress of an experimental fusion device. Due to these properties other fusion experiments like the WEST project have expressed interest in adopting DCS. For this purpose, essential parts of DCS must be unpinned from the ASDEX Upgrade environment by exposure or introduction of generalised interfaces. Re-organisation of DCS modules allows distinguishing between intrinsic framework core functions and device-specific applications. In particular, DCS must be prepared for deployment in different system environments with their own realisations for user interface, pulse schedule preparation, parameter server, time and event distribution, diagnostic and actuator systems, network communication and data archiving. The article explains the principles of the revised DCS structure, derives the necessary interface definitions and describes major steps to achieve the separation between general-purpose framework and fusion device specific components.

Investigation of Factors Affecting Microdialysis Probe Delivery and ...

African Journals Online (AJOL)

HP

Purpose: To investigate in vitro the factors affecting microdialysis probe delivery and recovery of puerarin . Methods: ... methods. Factors such as drug concentration, stirring speed, additives and length of membrane were ... The high performance liquid chromatography ..... Pharmacokinetic Modeling to Investigate Regional.

The General-Purpose Heat Source Radioisotope Thermoelectric Generator: Power for the Galileo and Ulysses missions

International Nuclear Information System (INIS)

Bennett, G.L.; Lombardo, J.J.; Hemler, R.J.; Peterson, J.R.

1986-01-01

Electrical power for NASA's Galileo mission to Jupiter and ESA's Ulysses mission to explore the polar regions of the Sun will be provided by General-Purpose Heat Source Radioisotope Thermo-electric Generators (GPHS-RTGs). Building upon the successful RTG technology used in the Voyager program, each GPHS-RTG will provide at least 285 W(e) at beginning-of-mission. The design concept has been proven through extensive tests of an electrically heated Engineering Unit and a nuclear-heated Qualification Unit. Four flight generators have been successfully assembled and tested for use on the Galileo and Ulysses spacecraft. All indications are that the GPHS-RTGs will meet or exceed the power requirement of the missions

Auditing Information System : Delivery Product Service

Directory of Open Access Journals (Sweden)

Purwoko Purwoko

2011-05-01

Full Text Available Purpose of the research is to ensure the securities of information system asset and to ensure if informa-tion system support the operational and data collected was valid. Research method that used in this research were library studies and field studies. Field studies such an observation, questioner, and inter-view. the expected result are founding the weakness of security management control, operational man-agement control, input control, and output control of risk happened in the company. Conclusion of this research are the system on the company work good and there’s no potential risk happened and make an impact to the delivery process of information system.Index Terms - Auditing Information system, Delivery product process.

General-purpose heat source project and space nuclear safety and fuels program. Progress reportt, January 1980

International Nuclear Information System (INIS)

Maraman, W.J.

1980-04-01

This formal monthly report covers the studies related to the use of 238 PuO 2 in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of the Los Alamos Scientific Laboratory. The two programs involved are the general-purpose heat source development and space nuclear safety and fuels. Most of the studies discussed here are of a continuing nature. Results and conclusions described may change as the work continues. Published reference to the results cited in this report should not be made without the explicit permission of the person in charge of the work

The impact of treatment complexity and computer-control delivery technology on treatment delivery errors

International Nuclear Information System (INIS)

Fraass, Benedick A.; Lash, Kathy L.; Matrone, Gwynne M.; Volkman, Susan K.; McShan, Daniel L.; Kessler, Marc L.; Lichter, Allen S.

1998-01-01

Purpose: To analyze treatment delivery errors for three-dimensional (3D) conformal therapy performed at various levels of treatment delivery automation and complexity, ranging from manual field setup to virtually complete computer-controlled treatment delivery using a computer-controlled conformal radiotherapy system (CCRS). Methods and Materials: All treatment delivery errors which occurred in our department during a 15-month period were analyzed. Approximately 34,000 treatment sessions (114,000 individual treatment segments [ports]) on four treatment machines were studied. All treatment delivery errors logged by treatment therapists or quality assurance reviews (152 in all) were analyzed. Machines 'M1' and 'M2' were operated in a standard manual setup mode, with no record and verify system (R/V). MLC machines 'M3' and 'M4' treated patients under the control of the CCRS system, which (1) downloads the treatment delivery plan from the planning system; (2) performs some (or all) of the machine set up and treatment delivery for each field; (3) monitors treatment delivery; (4) records all treatment parameters; and (5) notes exceptions to the electronically-prescribed plan. Complete external computer control is not available on M3; therefore, it uses as many CCRS features as possible, while M4 operates completely under CCRS control and performs semi-automated and automated multi-segment intensity modulated treatments. Analysis of treatment complexity was based on numbers of fields, individual segments, nonaxial and noncoplanar plans, multisegment intensity modulation, and pseudoisocentric treatments studied for a 6-month period (505 patients) concurrent with the period in which the delivery errors were obtained. Treatment delivery time was obtained from the computerized scheduling system (for manual treatments) or from CCRS system logs. Treatment therapists rotate among the machines; therefore, this analysis does not depend on fixed therapist staff on particular

SUPPORTIVE SUPERVISION AS A TECHNOLOGY OF IMPROVING THE QUALITY OF HOSPITAL CARE DELIVERY

Directory of Open Access Journals (Sweden)

Svetlana A. Mukhortova

2017-01-01

Full Text Available Improving the quality of medical care is a priority in countries with developed and developing health care system. There are various approaches to improve the quality and safety of patient’s care, as well as various strategies to encourage hospitals to achieve this goal. The purpose of the presented literature review was to analyze existing experience of the implementation of technology of supportive supervision in health care facilities to improve the quality of hospital care delivery. The data sources for publication were obtained from the following medical databases: PubMed, Cochrane Library, Medscape, e-library, and books on the topic of the review written by experts. The article discusses the results of the research studies demonstrating the successes and failures of supportive supervision technology application. Implementation of supportive supervision in medical facilities based on generalized experience of different countries is a promising direction in improving the quality of medical care delivery. This technology opens up opportunities to improve skills and work quality of the staff at pediatric hospitals in the Russian Federation.

14 CFR 1251.100 - Purpose.

Science.gov (United States)

2010-01-01

... General Provisions § 1251.100 Purpose. This part effectuates section 504 of the Rehabilitation Act of 1973... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Purpose. 1251.100 Section 1251.100... receiving Federal financial assistance. ...

Microcontainers - an oral drug delivery system for poorly soluble drugs

DEFF Research Database (Denmark)

Nielsen, Line Hagner; Petersen, Ritika Singh; Marizza, Paolo

In oral delivery, it can sometimes be necessary to employ drug delivery systems to achieve targeted delivery to the intestine. Microcontainers are polymeric, cylindrical devices in the micrometer size range (Figure 1), and are suggested as a promising oral drug delivery system [1],[2]. The purpose...... of these studies was to fabricate microcontainers in either SU-8 or biodegradable poly-L-lactic acid (PLLA), and fill the microcontainers with poorly soluble drugs. Furthermore, the application of the microcontainers as an oral drug delivery system was investigated in terms of release, in situ intestinal perfusion...... medium at pH 6.5 was observed. In situ intestinal perfusions were performed in rats of the Eudragit-coated ASSF-filled microcontainers and compared to a furosemide solution. At the end of the study, the small intestine was harvested from the rat and imaged under a light microscope. The absorption rate...

General Purpose Segmentation for Microorganisms in Microscopy Images

DEFF Research Database (Denmark)

Jensen, Sebastian H. Nesgaard; Moeslund, Thomas B.; Rankl, Christian

2014-01-01

In this paper, we propose an approach for achieving generalized segmentation of microorganisms in mi- croscopy images. It employs a pixel-wise classification strategy based on local features. Multilayer percep- trons are utilized for classification of the local features and is trained for each sp...

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Science.gov (United States)

Dubald, Marion; Bourgeois, Sandrine; Andrieu, Véronique; Fessi, Hatem

2018-01-01

The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly used in solution or in ointment for the ophthalmic route. However, their local bioavailability needs to be improved in order to decrease the frequency of administrations and the side effects and to increase their therapeutic efficiency. For this purpose, sustained release forms for ophthalmic delivery of antibiotics were developed. This review briefly describes the ocular administration with the ocular barriers and the currently topical forms. It focuses on experimental results to bypass the limitations of ocular antibiotic delivery with new ocular technology as colloidal and in situ gelling systems or with the improvement of existing forms as implants and contact lenses. Nanotechnology is presently a promising drug delivery way to provide protection of antibiotics and improve pathway through ocular barriers and deliver drugs to specific target sites. PMID:29342879

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Directory of Open Access Journals (Sweden)

Marion Dubald

2018-01-01

Full Text Available The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly used in solution or in ointment for the ophthalmic route. However, their local bioavailability needs to be improved in order to decrease the frequency of administrations and the side effects and to increase their therapeutic efficiency. For this purpose, sustained release forms for ophthalmic delivery of antibiotics were developed. This review briefly describes the ocular administration with the ocular barriers and the currently topical forms. It focuses on experimental results to bypass the limitations of ocular antibiotic delivery with new ocular technology as colloidal and in situ gelling systems or with the improvement of existing forms as implants and contact lenses. Nanotechnology is presently a promising drug delivery way to provide protection of antibiotics and improve pathway through ocular barriers and deliver drugs to specific target sites.

Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery

Directory of Open Access Journals (Sweden)

Chen CH

2015-03-01

Full Text Available Chun-Han Chen,1,2 Cheng-Chih Chang,1 Tsung-Hsien Shih,2 Ibrahim A Aljuffali,3 Ta-Sen Yeh,4,5 Jia-You Fang6–8 1Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, 2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; 3Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 4Department of Surgery, Chang Gung Memorial Hospital, 5School of Medicine, College of Medicine, 6Pharmaceutics Laboratory, Graduate Institute of Natural Products, 7Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, 8Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan Abstract: Roux-en-Y gastric bypass (RYGB is a popular surgery to reduce the body weight of obese patients. Although food intake is restricted by RYGB, drug absorption is also decreased. The purpose of this study was to develop novel self-nanoemulsifying drug delivery systems (SNEDDS for enhancing the oral delivery of silymarin, which has poor water solubility. The SNEDDS were characterized by size, zeta potential, droplet number, and morphology. A technique of RYGB was performed in Sprague-Dawley rats. SNEDDS were administered at a silymarin dose of 600 mg/kg in normal and RYGB rats for comparison with silymarin aqueous suspension and polyethylene glycol (PEG 400 solution. Plasma silibinin, the main active ingredient in silymarin, was chosen for estimating the pharmacokinetic parameters. SNEDDS diluted in simulated gastric fluid exhibited a droplet size of 190 nm with a spherical shape. The nanocarriers promoted silibinin availability via oral ingestion in RYGB rats by 2.5-fold and 1.5-fold compared to the suspension and PEG 400 solution, respectively. A significant double-peak concentration of silibinin was detected for RYGB rats receiving SNEDDS. Fluorescence

SNAP: A General Purpose Network Analysis and Graph Mining Library.

Science.gov (United States)

Leskovec, Jure; Sosič, Rok

2016-10-01

Large networks are becoming a widely used abstraction for studying complex systems in a broad set of disciplines, ranging from social network analysis to molecular biology and neuroscience. Despite an increasing need to analyze and manipulate large networks, only a limited number of tools are available for this task. Here, we describe Stanford Network Analysis Platform (SNAP), a general-purpose, high-performance system that provides easy to use, high-level operations for analysis and manipulation of large networks. We present SNAP functionality, describe its implementational details, and give performance benchmarks. SNAP has been developed for single big-memory machines and it balances the trade-off between maximum performance, compact in-memory graph representation, and the ability to handle dynamic graphs where nodes and edges are being added or removed over time. SNAP can process massive networks with hundreds of millions of nodes and billions of edges. SNAP offers over 140 different graph algorithms that can efficiently manipulate large graphs, calculate structural properties, generate regular and random graphs, and handle attributes and meta-data on nodes and edges. Besides being able to handle large graphs, an additional strength of SNAP is that networks and their attributes are fully dynamic, they can be modified during the computation at low cost. SNAP is provided as an open source library in C++ as well as a module in Python. We also describe the Stanford Large Network Dataset, a set of social and information real-world networks and datasets, which we make publicly available. The collection is a complementary resource to our SNAP software and is widely used for development and benchmarking of graph analytics algorithms.

Real-time traffic sign recognition based on a general purpose GPU and deep-learning.

Science.gov (United States)

Lim, Kwangyong; Hong, Yongwon; Choi, Yeongwoo; Byun, Hyeran

2017-01-01

We present a General Purpose Graphics Processing Unit (GPGPU) based real-time traffic sign detection and recognition method that is robust against illumination changes. There have been many approaches to traffic sign recognition in various research fields; however, previous approaches faced several limitations when under low illumination or wide variance of light conditions. To overcome these drawbacks and improve processing speeds, we propose a method that 1) is robust against illumination changes, 2) uses GPGPU-based real-time traffic sign detection, and 3) performs region detecting and recognition using a hierarchical model. This method produces stable results in low illumination environments. Both detection and hierarchical recognition are performed in real-time, and the proposed method achieves 0.97 F1-score on our collective dataset, which uses the Vienna convention traffic rules (Germany and South Korea).

43 CFR 418.28 - Conditions of delivery.

Science.gov (United States)

2010-10-01

... particulars including the known or estimated location and amounts; (3) The amount will not be included as a valid headgate delivery for purposes of computing the Project efficiency and resultant incentive credit... treated directly as a debit to Lahontan storage in the same manner as an efficiency debit. (b) District...

7 CFR 15b.1 - Purpose.

Science.gov (United States)

2010-01-01

... FEDERAL FINANCIAL ASSISTANCE General Provisions § 15b.1 Purpose. The purpose of this part is to implement... 7 Agriculture 1 2010-01-01 2010-01-01 false Purpose. 15b.1 Section 15b.1 Agriculture Office of the... receiving Federal financial assistance. ...

General practitioner participation in intranatal care in the northern region in 1983.

Science.gov (United States)

Marsh, G N; Cashman, H A; Russell, I T

1985-03-30

In 1983 a quarter of general practitioners in the Northern region of England cared for obstetric deliveries and half of these for a minimum of 10 deliveries a year. Most expected their intranatal work to remain at the same level or increase in the next 10 years. Most participating general practitioners did their own forceps deliveries and initiated inductions. Most out of hours deliveries were attended by the mother's own general practitioner or a partner. A quarter of all respondents had cared for planned and unplanned home births. Few were happy about attending them, but most would provide planned home care if urged to do so.

SU-E-T-254: Optimization of GATE and PHITS Monte Carlo Code Parameters for Uniform Scanning Proton Beam Based On Simulation with FLUKA General-Purpose Code

Energy Technology Data Exchange (ETDEWEB)

Kurosu, K [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Department of Medical Physics ' Engineering, Osaka University Graduate School of Medicine, Osaka (Japan); Takashina, M; Koizumi, M [Department of Medical Physics ' Engineering, Osaka University Graduate School of Medicine, Osaka (Japan); Das, I; Moskvin, V [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN (United States)

2014-06-01

Purpose: Monte Carlo codes are becoming important tools for proton beam dosimetry. However, the relationships between the customizing parameters and percentage depth dose (PDD) of GATE and PHITS codes have not been reported which are studied for PDD and proton range compared to the FLUKA code and the experimental data. Methods: The beam delivery system of the Indiana University Health Proton Therapy Center was modeled for the uniform scanning beam in FLUKA and transferred identically into GATE and PHITS. This computational model was built from the blue print and validated with the commissioning data. Three parameters evaluated are the maximum step size, cut off energy and physical and transport model. The dependence of the PDDs on the customizing parameters was compared with the published results of previous studies. Results: The optimal parameters for the simulation of the whole beam delivery system were defined by referring to the calculation results obtained with each parameter. Although the PDDs from FLUKA and the experimental data show a good agreement, those of GATE and PHITS obtained with our optimal parameters show a minor discrepancy. The measured proton range R90 was 269.37 mm, compared to the calculated range of 269.63 mm, 268.96 mm, and 270.85 mm with FLUKA, GATE and PHITS, respectively. Conclusion: We evaluated the dependence of the results for PDDs obtained with GATE and PHITS Monte Carlo generalpurpose codes on the customizing parameters by using the whole computational model of the treatment nozzle. The optimal parameters for the simulation were then defined by referring to the calculation results. The physical model, particle transport mechanics and the different geometrybased descriptions need accurate customization in three simulation codes to agree with experimental data for artifact-free Monte Carlo simulation. This study was supported by Grants-in Aid for Cancer Research (H22-3rd Term Cancer Control-General-043) from the Ministry of Health

16 CFR 1115.1 - Purpose.

Science.gov (United States)

2010-01-01

... Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SUBSTANTIAL PRODUCT HAZARD REPORTS General Interpretation § 1115.1 Purpose. The purpose of this part 1115 is to set forth the Consumer Product Safety Commission's (Commission's) interpretation of the reporting requirements imposed on...

Balancing Instructional Techniques and Delivery Formats in Capstone Business Strategy Courses

Science.gov (United States)

Alstete, Jeffrey W.; Beutell, Nicholas J.

2016-01-01

Purpose: The purpose of this paper is to contend that collegiate programs should carefully plan their capstone courses in light of the educational mission, pedagogical content knowledge, instructional techniques and delivery formats. Design/methodology/approach: This is a concept paper with elements of theory building from the case of business…

Verification of patient position and delivery of IMRT by electronic portal imaging

International Nuclear Information System (INIS)

Fielding, Andrew L.; Evans, Philip M.; Clark, Catharine H.

2004-01-01

Background and purpose: The purpose of the work presented in this paper was to determine whether patient positioning and delivery errors could be detected using electronic portal images of intensity modulated radiotherapy (IMRT). Patients and methods: We carried out a series of controlled experiments delivering an IMRT beam to a humanoid phantom using both the dynamic and multiple static field method of delivery. The beams were imaged, the images calibrated to remove the IMRT fluence variation and then compared with calibrated images of the reference beams without any delivery or position errors. The first set of experiments involved translating the position of the phantom both laterally and in a superior/inferior direction a distance of 1, 2, 5 and 10 mm. The phantom was also rotated 1 and 2 deg. For the second set of measurements the phantom position was kept fixed and delivery errors were introduced to the beam. The delivery errors took the form of leaf position and segment intensity errors. Results: The method was able to detect shifts in the phantom position of 1 mm, leaf position errors of 2 mm, and dosimetry errors of 10% on a single segment of a 15 segment IMRT step and shoot delivery (significantly less than 1% of the total dose). Conclusions: The results of this work have shown that the method of imaging the IMRT beam and calibrating the images to remove the intensity modulations could be a useful tool in verifying both the patient position and the delivery of the beam

41 CFR 101-6.202 - Purpose.

Science.gov (United States)

2010-07-01

... FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 6-MISCELLANEOUS REGULATIONS 6.2-Nondiscrimination in Programs Receiving Federal Financial Assistance § 101-6.202 Purpose. The purpose of this subpart is to... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Purpose. 101-6.202...

Comparative assessment of plasmid DNA delivery by encapsulation ...

African Journals Online (AJOL)

Purpose: To compare the gene delivery effectiveness of plasmid DNA (pDNA) encapsulated within poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles with that adsorbed on PLGA nanoparticles. Methods: PLGA nanoparticles were prepared using solvent-evaporation method. To encapsulate pDNA within the particles, ...

Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans

Science.gov (United States)

Brogden, Nicole K.; Banks, Stan L.; Crofford, Leslie J.; Stinchcomb, Audra L.

2013-01-01

Microneedles applied to the skin create micropores, allowing transdermal drug delivery of skin-impermeable compounds. The first human study with this technique demonstrated delivery of naltrexone (an opioid antagonist) for two to three days. Rapid micropore closure, however, blunts the delivery window. Application of diclofenac (an anti-inflammatory) allows seven days of naltrexone delivery in animals. Purpose the purpose of the current work was to demonstrate delivery of naltrexone for seven days following one microneedle treatment in humans. Methods Human subjects were treated with microneedles, diclofenac (or placebo), and naltrexone. Impedance measurements were used as a surrogate marker to measure micropore formation, and plasma naltrexone concentrations were measured for seven days post-microneedle application. Results Impedance dropped significantly from baseline to post-microneedle treatment, confirming micropore formation. Naltrexone was detected for seven days in Group 1 (diclofenac + naltrexone, n = 6), vs. 72 hours in Group 2 (placebo + naltrexone, n = 2). At study completion, a significant difference in impedance was observed between intact and microneedle-treated skin in Group 1 (confirming the presence of micropores). Conclusion This is the first study demonstrating week-long drug delivery after one microneedle application, which would increase patient compliance and allow delivery of therapies for chronic diseases. PMID:23761054

44 CFR 17.600 - Purpose.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 17.600 Section 17.600 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) § 17.600 Purpose. (a) The...

7 CFR 1703.100 - Purpose.

Science.gov (United States)

2010-01-01

... RURAL DEVELOPMENT Distance Learning and Telemedicine Loan and Grant Program-General § 1703.100 Purpose. The purpose of the Distance Learning and Telemedicine (DLT) Loan and Grant Program is to encourage and... telecommunications, computer networks, and related advanced technologies by students, teachers, medical professionals...

10 CFR 1009.1 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Purpose and scope. 1009.1 Section 1009.1 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) GENERAL POLICY FOR PRICING AND CHARGING FOR MATERIALS AND SERVICES SOLD BY DOE § 1009.1 Purpose and scope. (a) This part establishes Department of Energy policy for...

VoxelMages: a general-purpose graphical interface for designing geometries and processing DICOM images for PENELOPE.

Science.gov (United States)

Giménez-Alventosa, V; Ballester, F; Vijande, J

2016-12-01

The design and construction of geometries for Monte Carlo calculations is an error-prone, time-consuming, and complex step in simulations describing particle interactions and transport in the field of medical physics. The software VoxelMages has been developed to help the user in this task. It allows to design complex geometries and to process DICOM image files for simulations with the general-purpose Monte Carlo code PENELOPE in an easy and straightforward way. VoxelMages also allows to import DICOM-RT structure contour information as delivered by a treatment planning system. Its main characteristics, usage and performance benchmarking are described in detail. Copyright © 2016 Elsevier Ltd. All rights reserved.

"I Love Knowing That What I'm Doing Has Purpose": Male Instrumentalists Who Choose to Teach Elementary General Music

Science.gov (United States)

Shouldice, Heather Nelson

2017-01-01

Few entering music education students plan to teach in an elementary general music (EGM) setting, and the majority of those who teach EGM are female and have vocalist backgrounds. The purpose of this collective case study was to examine six male instrumentalists' decisions to pursue a career in EGM teaching rather than secondary instrumental…

45 CFR 99.24 - Evidentiary purpose.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Evidentiary purpose. 99.24 Section 99.24 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURE FOR HEARINGS FOR THE CHILD CARE AND DEVELOPMENT FUND Hearing Procedures § 99.24 Evidentiary purpose. The purpose of the...

ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform.

Science.gov (United States)

Li, Ming; Chou, Judy; King, Kristopher W; Jing, Jing; Wei, Dong; Yang, Liyu

2015-02-01

IC50 and EC50 values are commonly used to evaluate drug potency. Mass spectrometry (MS)-centric bioanalytical and biomarker labs are now conducting IC50/EC50 assays, which, if done manually, are tedious and error-prone. Existing bioanalytical sample preparation automation systems cannot meet IC50/EC50 assay throughput demand. A general-purpose, automation-assisted IC50/EC50 assay platform was developed to automate the calculations of spiking solutions and the matrix solutions preparation scheme, the actual spiking and matrix solutions preparations, as well as the flexible sample extraction procedures after incubation. In addition, the platform also automates the data extraction, nonlinear regression curve fitting, computation of IC50/EC50 values, graphing, and reporting. The automation-assisted IC50/EC50 assay platform can process the whole class of assays of varying assay conditions. In each run, the system can handle up to 32 compounds and up to 10 concentration levels per compound, and it greatly improves IC50/EC50 assay experimental productivity and data processing efficiency. © 2014 Society for Laboratory Automation and Screening.

General purpose nonlinear analysis program FINAS for elevated temperature design of FBR components

International Nuclear Information System (INIS)

Iwata, K.; Atsumo, H.; Kano, T.; Takeda, H.

1982-01-01

This paper presents currently available capabilities of a general purpose finite element nonlinear analysis program FINAS (FBR Inelastic Structural Analysis System) which has been developed at Power Reactor and Nuclear Fuel Development Corporation (PNC) since 1976 to support structural design of fast breeder reactor (FBR) components in Japan. This program is capable of treating inelastic responses of arbitrary complex structures subjected to static and dynamic load histories. Various types of finite element covering rods, beams, pipes, axisymmetric, two and three dimensional solids, plates and shells, are implemented in the program. The thermal elastic-plastic creep analysis is possible for each element type, with primary emphasis on the application to FBR components subjected to sustained or cyclic loads at elevated temperature. The program permits large deformation, buckling, fracture mechanics, and dynamic analyses for some of the element types and provides a number of options for automatic mesh generation and computer graphics. Some examples including elevated temperature effects are shown to demonstrate the accuracy and the efficiency of the program

Explosion overpressure test series: General-Purpose Heat Source development: Safety Verification Test program

International Nuclear Information System (INIS)

Cull, T.A.; George, T.G.; Pavone, D.

1986-09-01

The General-Purpose Heat Source (GPHS) is a modular, radioisotope heat source that will be used in radioisotope thermoelectric generators (RTGs) to supply electric power for space missions. The first two uses will be the NASA Galileo and the ESA Ulysses missions. The RTG for these missions will contain 18 GPHS modules, each of which contains four 238 PuO 2 -fueled clads and generates 250 W/sub (t)/. A series of Safety Verification Tests (SVTs) was conducted to assess the ability of the GPHS modules to contain the plutonia in accident environments. Because a launch pad or postlaunch explosion of the Space Transportation System vehicle (space shuttle) is a conceivable accident, the SVT plan included a series of tests that simulated the overpressure exposure the RTG and GPHS modules could experience in such an event. Results of these tests, in which we used depleted UO 2 as a fuel simulant, suggest that exposure to overpressures as high as 15.2 MPa (2200 psi), without subsequent impact, does not result in a release of fuel

7 CFR 3430.201 - Purpose.

Science.gov (United States)

2010-01-01

...-GENERAL AWARD ADMINISTRATIVE PROVISIONS Specialty Crop Research Initiative § 3430.201 Purpose. (a) Focus areas. The purpose of this program is to address the critical needs of the specialty crop industry by developing and disseminating science-based tools to address needs of specific crops and their regions...

10 CFR 140.1 - Purpose.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Purpose. 140.1 Section 140.1 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS General Provisions § 140.1 Purpose. The regulations in this part are issued to provide appropriate procedures and requirements for...

A computer-controlled conformal radiotherapy system. III: graphical simulation and monitoring of treatment delivery

International Nuclear Information System (INIS)

Kessler, Marc L.; McShan, Daniel L.; Fraass, Benedick A.

1995-01-01

Purpose: Safe and efficient delivery of radiotherapy using computer-controlled machines requires new procedures to design and verify the actual delivery of these treatments. Graphical simulation and monitoring techniques for treatment delivery have been developed for this purpose. Methods and Materials: A graphics-based simulator of the treatment machine and a set of procedures for creating and manipulating treatment delivery scripts are used to simulate machine motions, detect collisions, and monitor machine positions during treatment. The treatment delivery simulator is composed of four components: a three-dimensional dynamic model of the treatment machine; a motion simulation and collision detection algorithm, user-interface widgets that mimic the treatment machine's control and readout devices; and an icon-based interface for creating and manipulating treatment delivery scripts. These components are used in a stand-alone fashion for interactive treatment delivery planning and integrated with a machine control system for treatment implementation and monitoring. Results: A graphics-based treatment delivery simulator and a set of procedures for planning and monitoring computer-controlled treatment delivery have been developed and implemented as part of a comprehensive computer-controlled conformal radiotherapy system. To date, these techniques have been used to design and help monitor computer-controlled treatments on a radiotherapy machine for more than 200 patients. Examples using these techniques for treatment delivery planning and on-line monitoring of machine motions during therapy are described. Conclusion: A system that provides interactive graphics-based tools for defining the sequence of machine motions, simulating treatment delivery including collision detection, and presenting the therapists with continual visual feedback from the treatment machine has been successfully implemented for routine clinical use as part of an overall system for computer

Development and application of General Purpose Data Acquisition Shell (GPDAS) at advanced photon source

International Nuclear Information System (INIS)

Chung, Youngjoo; Kim, Keeman.

1991-01-01

An operating system shell GPDAS (General Purpose Data Acquisition Shell) on MS-DOS-based microcomputers has been developed to provide flexibility in data acquisition and device control for magnet measurements at the Advanced Photon Source. GPDAS is both a command interpreter and an integrated script-based programming environment. It also incorporates the MS-DOS shell to make use of the existing utility programs for file manipulation and data analysis. Features include: alias definition, virtual memory, windows, graphics, data and procedure backup, background operation, script programming language, and script level debugging. Data acquisition system devices can be controlled through IEEE488 board, multifunction I/O board, digital I/O board and Gespac crate via Euro G-64 bus. GPDAS is now being used for diagnostics R ampersand D and accelerator physics studies as well as for magnet measurements. Their hardware configurations will also be discussed. 3 refs., 3 figs

Design Project on Controlled-Release Drug Delivery Devices: Implementation, Management, and Learning Experiences

Science.gov (United States)

Xu, Qingxing; Liang, Youyun; Tong, Yen Wah; Wang, Chi-Hwa

2010-01-01

A design project that focuses on the subject of controlled-release drug delivery devices is presented for use in an undergraduate course on mass transfer. The purpose of the project is to introduce students to the various technologies used in the fabrication of drug delivery systems and provide a practical design exercise for understanding the…

Enhancement of therapeutic drug and DNA delivery into cells by electroporation

Energy Technology Data Exchange (ETDEWEB)

Rabussay, Dietmar [Genetronics, Inc., Department of Research and Development, 11199 Sorrento Valley Road, San Diego, CA (United States); Dev, Nagendu B [Genetronics, Inc., Department of Research and Development, 11199 Sorrento Valley Road, San Diego, CA (United States); Fewell, Jason [Valentis, Inc., 8301 New Trails Drive, The Woodlands, TX (United States); Smith, Louis C [Valentis, Inc., 8301 New Trails Drive, The Woodlands, TX (United States); Widera, Georg [Genetronics, Inc., Department of Research and Development, 11199 Sorrento Valley Road, San Diego, CA (United States); Zhang Lei [Genetronics, Inc., Department of Research and Development, 11199 Sorrento Valley Road, San Diego, CA (United States)

2003-02-21

The effectiveness of potentially powerful therapeutics, including DNA, is often limited by their inability to permeate the cell membrane efficiently. Electroporation (EP) also referred to as 'electropermeabilization' of the outer cell membrane renders this barrier temporarily permeable by inducing 'pores' across the lipid bilayer. For in vivo EP, the drug or DNA is delivered into the interstitial space of the target tissue by conventional means, followed by local EP. EP pulses of micro- to millisecond duration and field strengths of 100-1500 V cm{sup -1} generally enhance the delivery of certain chemotherapeutic drugs by three to four orders of magnitude and intracellular delivery of DNA several hundred-fold. We have used EP in clinical studies for human cancer therapy and in animals for gene therapy and DNA vaccination. Late stage squamous cell carcinomas of the head and neck were treated with intratumoural injection of bleomycin and subsequent EP. Of the 69 tumours treated, 25% disappeared completely and another 32% were reduced in volume by more than half. Residence time of bleomycin in electroporated tumours was significantly greater than in non-electroporated lesions. Histological findings and gene expression patterns after bleomycin-EP treatment indicated rapid apoptosis of the majority of tumour cells. In animals, we demonstrated the usefulness of EP for enhanced DNA delivery by achieving normalization of blood clotting times in haemophilic dogs, and by substantially increasing transgene expression in smooth muscle cells of arterial walls using a novel porous balloon EP catheter. Finally, we have found in animal experiments that the immune response to DNA vaccines can be dramatically enhanced and accelerated by EP and co-injection of micron-sized particles. We conclude that EP represents an effective, economical and safe approach to enhance the intracellular delivery, and thus potency, of important drugs and genes for therapeutic purposes

Enhancement of therapeutic drug and DNA delivery into cells by electroporation

International Nuclear Information System (INIS)

Rabussay, Dietmar; Dev, Nagendu B; Fewell, Jason; Smith, Louis C; Widera, Georg; Zhang Lei

2003-01-01

The effectiveness of potentially powerful therapeutics, including DNA, is often limited by their inability to permeate the cell membrane efficiently. Electroporation (EP) also referred to as 'electropermeabilization' of the outer cell membrane renders this barrier temporarily permeable by inducing 'pores' across the lipid bilayer. For in vivo EP, the drug or DNA is delivered into the interstitial space of the target tissue by conventional means, followed by local EP. EP pulses of micro- to millisecond duration and field strengths of 100-1500 V cm -1 generally enhance the delivery of certain chemotherapeutic drugs by three to four orders of magnitude and intracellular delivery of DNA several hundred-fold. We have used EP in clinical studies for human cancer therapy and in animals for gene therapy and DNA vaccination. Late stage squamous cell carcinomas of the head and neck were treated with intratumoural injection of bleomycin and subsequent EP. Of the 69 tumours treated, 25% disappeared completely and another 32% were reduced in volume by more than half. Residence time of bleomycin in electroporated tumours was significantly greater than in non-electroporated lesions. Histological findings and gene expression patterns after bleomycin-EP treatment indicated rapid apoptosis of the majority of tumour cells. In animals, we demonstrated the usefulness of EP for enhanced DNA delivery by achieving normalization of blood clotting times in haemophilic dogs, and by substantially increasing transgene expression in smooth muscle cells of arterial walls using a novel porous balloon EP catheter. Finally, we have found in animal experiments that the immune response to DNA vaccines can be dramatically enhanced and accelerated by EP and co-injection of micron-sized particles. We conclude that EP represents an effective, economical and safe approach to enhance the intracellular delivery, and thus potency, of important drugs and genes for therapeutic purposes. The safety and pharmaco

SU-D-201-03: During-Treatment Delivery Monitoring System for TomoTherapy

Energy Technology Data Exchange (ETDEWEB)

Chen, Q; Read, P [University of Virginia, Charlottesville, VA (United States)

2016-06-15

Purpose: Multiple error pathways can lead to delivery errors during the treatment course that cannot be caught with pre-treatment QA. While in vivo solutions are being developed for linacs, no such solution exists for tomotherapy. The purpose of this study is to develop a near real-time system for tomotherapy that can monitor the delivery and dose accumulation process during the treatment-delivery, which enable the user to assess the impact of delivery variations and/or errors and to interrupt the treatment if necessary. Methods: A program running on a tomotherapy planning station fetches the raw DAS data during treatment. Exit detector data is extracted as well as output, gantry angle, and other machine parameters. For each sample, the MLC open-close state is determined. The delivered plan is compared with the original plan via a Monte Carlo dose engine which transports fluence deviations from a pre-treatment Monte Carlo run. A report containing the difference in fluence, dose and DVH statistics is created in html format. This process is repeated until the treatment is completed. Results: Since we only need to compute the dose for the difference in fluence for a few projections each time, dose with 2% statistical uncertainty can be computed in less than 1 second on a 4-core cpu. However, the current bottleneck in this near real-time system is the repeated fetching and processing the growing DAS data file throughout the delivery. The frame rate drops from 10Hz at the beginning of treatment to 5Hz after 3 minutes and to 2Hz after 10 minutes. Conclusion: A during-treatment delivery monitor system has been built to monitor tomotherapy treatments. The system improves patient safety by allowing operators to assess the delivery variations and errors during treatment delivery and adopt appropriate actions.

SU-D-201-03: During-Treatment Delivery Monitoring System for TomoTherapy

International Nuclear Information System (INIS)

Chen, Q; Read, P

2016-01-01

Purpose: Multiple error pathways can lead to delivery errors during the treatment course that cannot be caught with pre-treatment QA. While in vivo solutions are being developed for linacs, no such solution exists for tomotherapy. The purpose of this study is to develop a near real-time system for tomotherapy that can monitor the delivery and dose accumulation process during the treatment-delivery, which enable the user to assess the impact of delivery variations and/or errors and to interrupt the treatment if necessary. Methods: A program running on a tomotherapy planning station fetches the raw DAS data during treatment. Exit detector data is extracted as well as output, gantry angle, and other machine parameters. For each sample, the MLC open-close state is determined. The delivered plan is compared with the original plan via a Monte Carlo dose engine which transports fluence deviations from a pre-treatment Monte Carlo run. A report containing the difference in fluence, dose and DVH statistics is created in html format. This process is repeated until the treatment is completed. Results: Since we only need to compute the dose for the difference in fluence for a few projections each time, dose with 2% statistical uncertainty can be computed in less than 1 second on a 4-core cpu. However, the current bottleneck in this near real-time system is the repeated fetching and processing the growing DAS data file throughout the delivery. The frame rate drops from 10Hz at the beginning of treatment to 5Hz after 3 minutes and to 2Hz after 10 minutes. Conclusion: A during-treatment delivery monitor system has been built to monitor tomotherapy treatments. The system improves patient safety by allowing operators to assess the delivery variations and errors during treatment delivery and adopt appropriate actions.

7 CFR 3052.100 - Purpose.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Purpose. 3052.100 Section 3052.100 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS General § 3052.100 Purpose. This...

7 CFR 1780.2 - Purpose.

Science.gov (United States)

2010-01-01

... (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.2 Purpose. Provide loan and grant funds for water and waste projects serving the most financially needy communities. Financial... 7 Agriculture 12 2010-01-01 2010-01-01 false Purpose. 1780.2 Section 1780.2 Agriculture...

7 CFR 550.19 - Purpose.

Science.gov (United States)

2010-01-01

... GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS Management of Agreements Financial Management § 550.19 Purpose. Sections 550.20 through 550.25 of this subpart prescribe standards for financial... 7 Agriculture 6 2010-01-01 2010-01-01 false Purpose. 550.19 Section 550.19 Agriculture Regulations...

SPIDR, a general-purpose readout system for pixel ASICs

International Nuclear Information System (INIS)

Heijden, B. van der; Visser, J.; Beuzekom, M. van; Boterenbrood, H.; Munneke, B.; Schreuder, F.; Kulis, S.

2017-01-01

The SPIDR (Speedy PIxel Detector Readout) system is a flexible general-purpose readout platform that can be easily adapted to test and characterize new and existing detector readout ASICs. It is originally designed for the readout of pixel ASICs from the Medipix/Timepix family, but other types of ASICs or front-end circuits can be read out as well. The SPIDR system consists of an FPGA board with memory and various communication interfaces, FPGA firmware, CPU subsystem and an API library on the PC . The FPGA firmware can be adapted to read out other ASICs by re-using IP blocks. The available IP blocks include a UDP packet builder, 1 and 10 Gigabit Ethernet MAC's and a 'soft core' CPU . Currently the firmware is targeted at the Xilinx VC707 development board and at a custom board called Compact-SPIDR . The firmware can easily be ported to other Xilinx 7 series and ultra scale FPGAs. The gap between an ASIC and the data acquisition back-end is bridged by the SPIDR system. Using the high pin count VITA 57 FPGA Mezzanine Card (FMC) connector only a simple chip carrier PCB is required. A 1 and a 10 Gigabit Ethernet interface handle the connection to the back-end. These can be used simultaneously for high-speed data and configuration over separate channels. In addition to the FMC connector, configurable inputs and outputs are available for synchronization with other detectors. A high resolution (≈ 27 ps bin size) Time to Digital converter is provided for time stamping events in the detector. The SPIDR system is frequently used as readout for the Medipix3 and Timepix3 ASICs. Using the 10 Gigabit Ethernet interface it is possible to read out a single chip at full bandwidth or up to 12 chips at a reduced rate. Another recent application is the test-bed for the VeloPix ASIC, which is developed for the Vertex Detector of the LHCb experiment. In this case the SPIDR system processes the 20 Gbps scrambled data stream from the VeloPix and distributes it over four

A novel pressed porous silicon-polycaprolactone composite as a dual-purpose implant for the delivery of cells and drugs to the eye.

Science.gov (United States)

Irani, Yazad D; Tian, Yuan; Wang, Mengjia; Klebe, Sonja; McInnes, Steven J; Voelcker, Nicolas H; Coffer, Jeffery L; Williams, Keryn A

2015-10-01

Dysfunction of corneal epithelial stem cells can result in painful and blinding disease of the ocular surface. In such cases, treatment may involve transfer of growth factor and normal adult stem cells to the ocular surface. Our purpose was to develop an implantable scaffold for the delivery of drugs and cells to the ocular surface. We examined the potential of novel composite biomaterials fabricated from electrospun polycaprolactone (PCL) fibres into which nanostructured porous silicon (pSi) microparticles of varying sizes (150-250 μm or <40 μm) had been pressed. The PCL fabric provided a flexible support for mammalian cells, whereas the embedded pSi provided a substantial surface area for efficient delivery of adsorbed drugs and growth factors. Measurements of tensile strength of these composites revealed that the pSi did not strongly influence the mechanical properties of the polymer microfiber component for the Si loadings evaluated. Human lens epithelial cells (SRA01/04) attached to the composite materials, and exhibited enhanced attachment and growth when the materials were coated with foetal bovine serum. To examine the ability of the materials to deliver a small-drug payload, pSi microparticles were loaded with fluorescein diacetate prior to cell attachment. After 6 hours (h), cells exhibited intracellular fluorescence, indicative of transfer of the fluorescein diacetate into viable cells and its subsequent enzymatic conversion to fluorescein. To investigate loading of large-molecule biologics, murine BALB/c 3T3 cells, responsive to epidermal growth factor, insulin and transferrin, were seeded on composite materials. The cells showed significantly more proliferation at 48 h when seeded on composites loaded with these biologics, than on unloaded composites. No cell proliferation was observed on PCL alone, indicating the biologics had loaded into the pSi microparticles. Drug release, measured by ELISA for insulin, indicated a burst followed by a slower

Digital dental photography. Part 2: Purposes and uses.

Science.gov (United States)

Ahmad, I

2009-05-09

Although the primary purpose of using digital photography in dentistry is for recording various aspects of clinical information in the oral cavity, other benefits also accrue. Detailed here are the uses of digital images for dento-legal documentation, education, communication with patients, dental team members and colleagues and for portfolios, and marketing. These uses enhance the status of a dental practice and improve delivery of care to patients.

33 CFR 135.1 - Purpose.

Science.gov (United States)

2010-07-01

... FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND General § 135.1 Purpose... oil pollution liability and compensation, including the administration and general operation of the fund established under Title III of the Outer Continental Shelf Lands Act Amendments of 1978 (Pub. L...

General-purpose heat source: Research and development program, radioisotope thermoelectric generator/thin fragment impact test

International Nuclear Information System (INIS)

Reimus, M.A.H.; Hinckley, J.E.

1996-11-01

The general-purpose heat source provides power for space missions by transmitting the heat of 238 Pu decay to an array of thermoelectric elements in a radioisotope thermoelectric generator (RTG). Because the potential for a launch abort or return from orbit exists for any space mission, the heat source response to credible accident scenarios is being evaluated. This test was designed to provide information on the response of a loaded RTG to impact by a fragment similar to the type of fragment produced by breakup of the spacecraft propulsion module system. The results of this test indicated that impact by a thin aluminum fragment traveling at 306 m/s may result in significant damage to the converter housing, failure of one fueled clad, and release of a small quantity of fuel

19 CFR 212.01 - Purpose.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Purpose. 212.01 Section 212.01 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT General Provisions § 212.01 Purpose. (a) The Equal Access to...

Batangas Heavy Fabrication Yard Multi-Purpose Cooperative: Basis for Business Operation

Directory of Open Access Journals (Sweden)

JENNIFER D. MASICAT

2014-08-01

Full Text Available This research aimed to determine the proposed business initiatives to enhance the operation of Batangas Heavy Fabrication Yard Multi-Purpose Cooperative for the long survival and growth. More specifically, it shall answer the following objectives to describe the profile of the respondents in terms of their age, gender, type of membership and shared capital; to assess the business operation of the cooperative in the aspects of its management, marketing, finances, facilities and technology and their delivery of services; to identify the problems encountered by the cooperative in its business operation; to determine the significant relationship between the profile of the respondents and their assessment to its business operation; and to propose an action plan and to assess the business operation of BHFY Multi-Purpose Cooperative. The researcher used the descriptive correlation design in the study to obtain information concerning the current status of the BHFY-MPC cooperative; to describe what exists with respect to the variables or conditions in a situation. Based on the result, majority of the members are aged 51 to 55 years old, holding the regular type of membership and have a shared capital ranging from 51,001 to 100,000.The finding of the study states that the BHFY Multi-purpose cooperative performs well in terms of its management, marketing, finances, facilities and technology and delivery of services. Also, there are problems seldom encountered in the operation of the cooperative but the cooperative never encountered problems like overinvestment, ineffective leadership of management team and board of directors, inadequate source of fund, income of cooperative affected by negative issues and mismanagement of funds by the officers. Also, the type of membership influences the members’ assessment on the type of delivery of services; moreover, age contributes to the assessment of the business operation in terms of management and delivery of

Helical tomotherapy with dynamic running-start-stop delivery compared to conventional tomotherapy delivery

International Nuclear Information System (INIS)

Rong, Yi; Chen, Yu; Lu, Weiguo; Shang, Lu; Zuo, Li; Chen, Quan

2014-01-01

Purpose: Despite superior target dose uniformity, helical tomotherapy ® (HT) may involve a trade-off between longitudinal dose conformity and beam-on time (BOT), due to the limitation of only three available jaw sizes with the conventional HT (1.0, 2.5, and 5.0 cm). The recently introduced dynamic running-start-stop (RSS) delivery allows smaller jaw opening at the superior and inferior ends of the target when a sharp penumbra is needed. This study compared the dosimetric performance of RSS delivery with the fixed jaw HT delivery. Methods: Twenty patient cases were selected and deidentified prior to treatment planning, including 16 common clinical cases (brain, head and neck (HN), lung, and prostate) and four special cases of whole brain with hippocampus avoidance (WBHA) that require a high degree of dose modulation. HT plans were generated for common clinical cases using the fixed 2.5 cm jaw width (HT2.5) and WBHA cases using 1.0 cm (HT1.0). The jaw widths for RSS were preset with a larger size (RSS5.0 vs HT2.5 and RSS2.5 vs HT1.0). Both delivery techniques were planned based on identical contours, prescriptions, and planning objectives. Dose indices for targets and critical organs were compared using dose-volume histograms, BOT, and monitor units. Results: The average BOT was reduced from 4.8 min with HT2.5 to 2.5 min with RSS5.0. Target dose homogeneity with RSS5.0 was shown comparable to HT2.5 for common clinical sites. Superior normal tissue sparing was observed in RSS5.0 for optic nerves and optic chiasm in brain and HN cases. RSS5.0 demonstrated improved dose sparing for cord and esophagus in lung cases, as well as penile bulb in prostate cases. The mean body dose was comparable for both techniques. For the WBHA cases, the target homogeneity was significantly degraded in RSS2.5 without distinct dose sparing for hippocampus, compared to HT1.0. Conclusions: Compared to the fixed jaw HT delivery, RSS combined with a larger jaw width provides faster treatment

Helical tomotherapy with dynamic running-start-stop delivery compared to conventional tomotherapy delivery

Energy Technology Data Exchange (ETDEWEB)

Rong, Yi, E-mail: yi.rong@osumc.edu [Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210 (United States); Chen, Yu; Lu, Weiguo [21st Century Oncology, Madison, Wisconsin 53719 (United States); Shang, Lu [Guangxi Polytechnic of Construction and Technology, Nanning (China); Zuo, Li [Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, Ohio 43210 (United States); Chen, Quan [Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22904 (United States)

2014-05-15

Purpose: Despite superior target dose uniformity, helical tomotherapy{sup ®} (HT) may involve a trade-off between longitudinal dose conformity and beam-on time (BOT), due to the limitation of only three available jaw sizes with the conventional HT (1.0, 2.5, and 5.0 cm). The recently introduced dynamic running-start-stop (RSS) delivery allows smaller jaw opening at the superior and inferior ends of the target when a sharp penumbra is needed. This study compared the dosimetric performance of RSS delivery with the fixed jaw HT delivery. Methods: Twenty patient cases were selected and deidentified prior to treatment planning, including 16 common clinical cases (brain, head and neck (HN), lung, and prostate) and four special cases of whole brain with hippocampus avoidance (WBHA) that require a high degree of dose modulation. HT plans were generated for common clinical cases using the fixed 2.5 cm jaw width (HT2.5) and WBHA cases using 1.0 cm (HT1.0). The jaw widths for RSS were preset with a larger size (RSS5.0 vs HT2.5 and RSS2.5 vs HT1.0). Both delivery techniques were planned based on identical contours, prescriptions, and planning objectives. Dose indices for targets and critical organs were compared using dose-volume histograms, BOT, and monitor units. Results: The average BOT was reduced from 4.8 min with HT2.5 to 2.5 min with RSS5.0. Target dose homogeneity with RSS5.0 was shown comparable to HT2.5 for common clinical sites. Superior normal tissue sparing was observed in RSS5.0 for optic nerves and optic chiasm in brain and HN cases. RSS5.0 demonstrated improved dose sparing for cord and esophagus in lung cases, as well as penile bulb in prostate cases. The mean body dose was comparable for both techniques. For the WBHA cases, the target homogeneity was significantly degraded in RSS2.5 without distinct dose sparing for hippocampus, compared to HT1.0. Conclusions: Compared to the fixed jaw HT delivery, RSS combined with a larger jaw width provides faster

Litrani: a general purpose Monte-Carlo program simulating light propagation in isotropic or anisotropic media

International Nuclear Information System (INIS)

Gentit, F.-X.

2002-01-01

Litrani is a general purpose Monte-Carlo program simulating light propagation in any type of setup describable by the shapes provided by ROOT. Each shape may be made of a different material. Dielectric constant, absorption length and diffusion length of materials may depend upon wavelength. Dielectric constant and absorption length may be anisotropic. Each face of a volume is either partially or totally in contact with a face of another volume, or covered with some wrapping having defined characteristics of absorption, reflection and diffusion. When in contact with another face of another volume, the possibility exists to have a thin slice of width d and index n between the two faces. The program has various sources of light: spontaneous photons, photons coming from an optical fibre, photons generated by the crossing of particles or photons generated by an electromagnetic shower. The time and wavelength spectra of emitted photons may reproduce any scintillation spectrum. As detectors, phototubes, APD, or any general type of surface or volume detectors may be specified. The aim is to follow each photon until it is absorbed or detected. Quantities to be delivered by the program are the proportion of photons detected, and the time distribution for the arrival of these, or the various ways photons may be lost

Oral controlled release drug delivery system and Characterization of oral tablets; A review

Directory of Open Access Journals (Sweden)

Muhammad Zaman

2016-01-01

Full Text Available Oral route of drug administration is considered as the safest and easiest route of drug administration. Control release drug delivery system is the emerging trend in the pharmaceuticals and the oral route is most suitable for such kind of drug delivery system. Oral route is more convenient for It all age group including both pediatric and geriatrics. There are various systems which are adopted to deliver drug in a controlled manner to different target sites through oral route. It includes diffusion controlled drug delivery systems; dissolution controlled drug delivery systems, osmotically controlled drug delivery systems, ion-exchange controlled drug delivery systems, hydrodynamically balanced systems, multi-Particulate drug delivery systems and microencapsulated drug delivery system. The systems are formulated using different natural, semi-synthetic and synthetic polymers. The purpose of the review is to provide information about the orally controlled drug delivery system, polymers which are used to formulate these systems and characterizations of one of the most convenient dosage form which is the tablets. 

7 CFR 1980.310 - Loan purposes.

Science.gov (United States)

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Loan purposes. 1980.310 Section 1980.310 Agriculture... REGULATIONS (CONTINUED) GENERAL Rural Housing Loans § 1980.310 Loan purposes. The purpose of a loan guaranteed... applicant as a primary residence. The loan may be to purchase a new dwelling or an existing dwelling. The...

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Directory of Open Access Journals (Sweden)

Jafar Ezzati Nazhad Dolatabadi

2015-06-01

Full Text Available In recent years, nanomaterials have been widely applied as advanced drug and gene delivery nanosystems. Among them, solid lipid nanoparticles (SLNs have attracted great attention as colloidal drug delivery systems for incorporating hydrophilic or lipophilic drugs and various macromolecules as well as proteins and nucleic acids. Therefore, SLNs offer great promise for controlled and site specific drug and gene delivery. This article includes general information about SLN structures and properties, production procedures, characterization. In addition, recent progress on development of drug and gene delivery systems using SLNs was reviewed.

A Fast General-Purpose Clustering Algorithm Based on FPGAs for High-Throughput Data Processing

CERN Document Server

Annovi, A; The ATLAS collaboration; Castegnaro, A; Gatta, M

2012-01-01

We present a fast general-purpose algorithm for high-throughput clustering of data ”with a two dimensional organization”. The algorithm is designed to be implemented with FPGAs or custom electronics. The key feature is a processing time that scales linearly with the amount of data to be processed. This means that clustering can be performed in pipeline with the readout, without suffering from combinatorial delays due to looping multiple times through all the data. This feature makes this algorithm especially well suited for problems where the data has high density, e.g. in the case of tracking devices working under high-luminosity condition such as those of LHC or Super-LHC. The algorithm is organized in two steps: the first step (core) clusters the data; the second step analyzes each cluster of data to extract the desired information. The current algorithm is developed as a clustering device for modern high-energy physics pixel detectors. However, the algorithm has much broader field of applications. In ...

General-purpose heat source project and space nuclear safety and fuels program. Progress report

International Nuclear Information System (INIS)

Maraman, W.J.

1980-02-01

Studies related to the use of 238 PuO 2 in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of LASL are presented. The three programs involved are: general-purpose heat source development; space nuclear safety; and fuels program. Three impact tests were conducted to evaluate the effects of a high temperature reentry pulse and the use of CBCF on impact performance. Additionally, two 238 PuO 2 pellets were encapsulated in Ir-0.3% W for impact testing. Results of the clad development test and vent testing are noted. Results of the environmental tests are summarized. Progress on the Stirling isotope power systems test and the status of the improved MHW tests are indicated. The examination of the impact failure of the iridium shell of MHFT-65 at a fuel pass-through continued. A test plan was written for vibration testing of the assembled light-weight radioisotopic heater unit. Progress on fuel processing is reported

21 CFR 1240.80 - General requirements for water for drinking and culinary purposes.

Science.gov (United States)

2010-04-01

... culinary purposes. 1240.80 Section 1240.80 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... requirements for water for drinking and culinary purposes. Only potable water shall be provided for drinking and culinary purposes by any operator of a conveyance engaged in interstate traffic, except as...

Optimization of a general-purpose, actively scanned proton beamline for ocular treatments: Geant4 simulations.

Science.gov (United States)

Piersimoni, Pierluigi; Rimoldi, Adele; Riccardi, Cristina; Pirola, Michele; Molinelli, Silvia; Ciocca, Mario

2015-03-08

The Italian National Center for Hadrontherapy (CNAO, Centro Nazionale di Adroterapia Oncologica), a synchrotron-based hospital facility, started the treatment of patients within selected clinical trials in late 2011 and 2012 with actively scanned proton and carbon ion beams, respectively. The activation of a new clinical protocol for the irradiation of uveal melanoma using the existing general-purpose proton beamline is foreseen for late 2014. Beam characteristics and patient treatment setup need to be tuned to meet the specific requirements for such a type of treatment technique. The aim of this study is to optimize the CNAO transport beamline by adding passive components and minimizing air gap to achieve the optimal conditions for ocular tumor irradiation. The CNAO setup with the active and passive components along the transport beamline, as well as a human eye-modeled detector also including a realistic target volume, were simulated using the Monte Carlo Geant4 toolkit. The strong reduction of the air gap between the nozzle and patient skin, as well as the insertion of a range shifter plus a patient-specific brass collimator at a short distance from the eye, were found to be effective tools to be implemented. In perspective, this simulation toolkit could also be used as a benchmark for future developments and testing purposes on commercial treatment planning systems.

Mode of delivery is not associated with celiac disease

DEFF Research Database (Denmark)

Sander, Stine Dydensborg; Hansen, Anne Vinkel; Størdal, Ketil

2018-01-01

Purpose: The purpose of this study was to investigate the association between mode of delivery and the risk of celiac disease in two large population-based birth cohorts with different prevalence of diagnosed celiac disease. Patients and methods: This is an observational register-based cohort study...... were born in Norway from January 1, 2004 to December 31, 2012. Results: We included 1,051,028 children from Denmark. Cesarean sections were registered for 196,512 children (18.9%). Diagnosed celiac disease was registered for 1,395 children (0.13%). We included 537,457 children from Norway. Cesarean...... sections were registered for 90,128 children (16.8%). Diagnosed celiac disease was registered for 1,919 children (0.35%). We found no association between the mode of delivery and the risk of diagnosed celiac disease. The adjusted odds ratio for celiac disease for children delivered by any type of cesarean...

29 CFR 99.100 - Purpose.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Purpose. 99.100 Section 99.100 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS General § 99.100 Purpose. This part sets forth standards for obtaining consistency and uniformity among Federal agencies for the...

An auxiliary frequency tracking system for general purpose lock-in amplifiers

Science.gov (United States)

Xie, Kai; Chen, Liuhao; Huang, Anfeng; Zhao, Kai; Zhang, Hanlu

2018-04-01

Lock-in amplifiers (LIAs) are designed to measure weak signals submerged by noise. This is achieved with a signal modulator to avoid low-frequency noise and a narrow-band filter to suppress out-of-band noise. In asynchronous measurement, even a slight frequency deviation between the modulator and the reference may lead to measurement error because the filter’s passband is not flat. Because many commercial LIAs are unable to track frequency deviations, in this paper we propose an auxiliary frequency tracking system. We analyze the measurement error caused by the frequency deviation and propose both a tracking method and an auto-tracking system. This approach requires only three basic parameters, which can be obtained from any general purpose LIA via its communications interface, to calculate the frequency deviation from the phase difference. The proposed auxiliary tracking system is designed as a peripheral connected to the LIA’s serial port, removing the need for an additional power supply. The test results verified the effectiveness of the proposed system; the modified commercial LIA (model SR-850) was able to track the frequency deviation and continuous drift. For step frequency deviations, a steady tracking error of less than 0.001% was achieved within three adjustments, and the worst tracking accuracy was still better than 0.1% for a continuous frequency drift. The tracking system can be used to expand the application scope of commercial LIAs, especially for remote measurements in which the modulation clock and the local reference are separated.

Use of a general-purpose heat-transfer code for casting simulation

International Nuclear Information System (INIS)

Erickson, W.C.

1975-07-01

The practical use of numerical techniques in simulating casting solidification dictate that a general purpose heat transfer code be used and that results be obtained in an easy-to-analyze format. Color film plotting routines were developed for use with NASA's CINDA-3G heat transfer code; the combination of which meet the above criteria. The subroutine LQSLTR written for SINDA, the successor to CINDA-3G, was verified by comparing calculated results obtained using LQSLTR with those obtained using the specific heat method for handling the heat of fusion. Excellent agreement existed when similar data was used. When the more restrictive requirement of a 1 0 F melting range was used, comparable results were obtained. Uranium and lead rod castings were cast in instrumented graphite molds and the solidification sequence simulated using CINDA-3G. Discrepancies attributed to initial assumptions of instantaneous mold filling, uniform melt temperature, and intimate metal/mold contact were encountered. Further calculations using a model incorporating a gap between the mold and casting showed that the intimate contact assumption could not be used; a three-dimensional model also showed that the thermocouple assemblies used with the platinum--platinum-10 percent rhodium were a significant perturbation to the system. An L-shaped steel casting was simulated and the results compared to those reported in the literature. The experimental data for this casting were reproduced within the accuracy permitted by the thermal conductivity of the sand, thus demonstrating that agreement can be obtained when the mold material does not act as a chill. (U.S.)

Novel drug delivery strategies for porphyrins and porphyrin precursors

Science.gov (United States)

Morrow, D. I. J.; Donnelly, R. F.

2009-06-01

superficial lesions, such as actinic keratosis. In addition, photodynamic antimicrobial chemotherapy (PACT) is attracting increasing interest for the treatment of infection. However, delivery strategies for topical PDT and PACT are still based on application of rather simplistic cream and solution formulations, with little consideration given to thermodynamics, targeting or the physicochemical properties of the active agent. Purpose-designed dosage forms for topical delivery of aminolevulinic acid or its esters include creams containing penetration enhancers and/or iron chelators, pressure sensitive patches and bioadhesive patches. Such systems aim to enhance drug delivery across the stratum corneum and keratinised debris overlying neoplastic lesions and improve subsequent protoporphyrin IX (PpIX) production. The alternative to using porphyrin precursors is the use of pre-formed photosensitisers. However, owing to their relatively high molecular weights, conventional topical application is not appropriate. Innovative strategies, such as the use of needle-free injections and microneedle arrays, bypass the stratum corneum, enabling rapid and targeted delivery not only porphyrin precursors but also pre-formed photosensitisers. This presentation will review drug delivery work published to date in the fields of PDT and PACT. In addition, the benefits of employing the latest advances in pharmaceutical technology will be highlighted.

Cesarean Delivery in Women With Genital Herpes in Washington State, 1989–1991

Directory of Open Access Journals (Sweden)

Jeanne M. Marrazzo

1997-01-01

Full Text Available Objective: The purpose of this study was to determine whether the proportion of cesarean deliveries in pregnant women with a history of genital herpes and no active lesions at birth is higher than that in women with no history of genital herpes, and to determine whether this risk was modified by birth facilities' underlying prevalence of cesarean delivery.

A general purpose tomographic program with combined inversions

International Nuclear Information System (INIS)

Xu Wenbin; Dong Jiafu; Li Fanzhu

1996-01-01

A general tomographic program has been developed by combining the Bessel expansion with the Zernicke expansion. It is useful for studying of the magnetic island structure of the tearing mode and in reconstructing the density profiles of impurities in tokamak plasmas. This combined method have the advantages of both expansions, i.e. there will be no spurious images in the edge and it will be of high inverse precision in the center of plasma

Development of a Gastroretentive Drug Delivery System based on ...

African Journals Online (AJOL)

Erah

Purpose: The aim of this work was to synthesize superporous hydrogels of rosiglitazone using chitosan and to study its swelling behaviour for application as a gastroretentive drug delivery system. Methods: Chitosan superporous hydrogels were synthesized using glyoxal as a crosslinking agent by gas blowing method.

Newborns from deliveries with epidural anaesthesia

Directory of Open Access Journals (Sweden)

Avramović Lidija

2010-01-01

Full Text Available Introduction. The use of epidural anaesthesia in delivery with the purpose to reduce pain and fear in a pregnant woman has the influence on the physiological status of the woman in childbirth and the course of delivery. From the epidural space of the pregnant woman, one part of free anaesthetic comes in the foetal circulation through the mother's circulation and placenta and connects with the foetal proteins. A lower value of albumins and serum proteins in the foetal circulation give bigger free fraction of anaesthetic which is accumulated in the foetal liver, brain and heart full of blood. Objective. The aim of the study was to examine the influence of epidural anaesthesia on the newborn. Methods. Retrospective study of 6,398 documents of newborns was performed in our Clinic of Gynaecology and Obstetrics 'Narodni front' during 2006. The first group was made of 455 newborns from deliveries with epidural anaesthesia and the second was the control group of 5,943 remaining newborns. In both groups we analysed the following: sex, week of gestation, weight, Apgar score, measure of care and resuscitation, perinatal morbidity and then the obtained results were compared. Results. Most of deliveries were vaginal without obstetric intervention (86.6%. The number of deliveries finished with vacuum extractor (4.6% was statistically significantly bigger in the group with epidural anaesthesia than in the control group. Most of the newborns in the first group were born on time (96.5% in 39.0±1.0 week of gestation and with foetal weight 3448±412 grammes. There was no statistical significance in Apgar score between both groups. Epidural anaesthesia does not increase the degree of the newborn's injury. Lower pH of blood was found in the newborns from deliveries with vacuum extractor or operated on (the Ceasarean section. Conclusion. Application of epidural anaesthesia decreases duration of delivery and has no adverse effects on the newborn and hypoxic

Safety design integrated in the building delivery system

DEFF Research Database (Denmark)

Jørgensen, Kirsten

2013-01-01

. The purpose of this article is to demonstrate how safety and health can be integrated in the design phases integrated in the management delivery systems within construction, The method for the research was to go through the building delivery system step by step and create a normative description of what, when......In construction, it is important to view safety and health as an integrated part of the way that “designers” are working. The designers cowers architects, constructors, engineers and others who carry out their consulting services in the design phase of a construction project. The philosophy...... and how to fully integrate safety in each part of the process. The result is a concept and guideline including control forms for how to integrate safety design in the Building Delivery System plus what to do and when. The concept has been tested in an educational context. The practical value...

Adhesion barriers at cesarean delivery: advertising compared with the evidence.

Science.gov (United States)

Albright, Catherine M; Rouse, Dwight J

2011-07-01

Cesarean delivery, the most common surgery performed in the United States, is complicated by adhesion formation in 24-73% of cases. Because adhesions have potential sequelae, different synthetic adhesion barriers are currently heavily marketed as a means of reducing adhesion formation resultant from cesarean delivery. However, their use for this purpose has been studied in only two small, nonblinded and nonrandomized trials, both of which were underpowered and subject to bias. Neither demonstrated improvement in meaningful clinical outcomes. In the only cost-effectiveness analysis of adhesion barriers to date, the use of synthetic adhesion barriers was cost-effective only when the subsequent rate of small bowel obstruction was at least 2.4%, a rate far higher than that associated with cesarean delivery. In fact, intra-abdominal adhesions from prior cesarean delivery rarely cause maternal harm and have not been demonstrated to adversely affect perinatal outcome. Based on our review of the available literature, we think the use of adhesion barriers at the time of cesarean delivery would be ill-advised at the present time.

Peptide and protein delivery using new drug delivery systems.

Science.gov (United States)

Jain, Ashish; Jain, Aviral; Gulbake, Arvind; Shilpi, Satish; Hurkat, Pooja; Jain, Sanjay K

2013-01-01

Pharmaceutical and biotechnological research sorts protein drug delivery systems by importance based on their various therapeutic applications. The effective and potent action of the proteins/peptides makes them the drugs of choice for the treatment of numerous diseases. Major research issues in protein delivery include the stabilization of proteins in delivery devices and the design of appropriate target-specific protein carriers. Many efforts have been made for effective delivery of proteins/peptidal drugs through various routes of administrations for successful therapeutic effects. Nanoparticles made of biodegradable polymers such as poly lactic acid, polycaprolactone, poly(lactic-co-glycolic acid), the poly(fumaric-co-sebacic) anhydride chitosan, and modified chitosan, as well as solid lipids, have shown great potential in the delivery of proteins/peptidal drugs. Moreover, scientists also have used liposomes, PEGylated liposomes, niosomes, and aquasomes, among others, for peptidal drug delivery. They also have developed hydrogels and transdermal drug delivery systems for peptidal drug delivery. A receptor-mediated delivery system is another attractive strategy to overcome the limitation in drug absorption that enables the transcytosis of the protein across the epithelial barrier. Modification such as PEGnology is applied to various proteins and peptides of the desired protein and peptides also increases the circulating life, solubility and stability, pharmacokinetic properties, and antigenicity of protein. This review focuses on various approaches for effective protein/peptidal drug delivery, with special emphasis on insulin delivery.

General-Purpose Heat Source Safety Verification Test program: Edge-on flyer plate tests

International Nuclear Information System (INIS)

George, T.G.

1987-03-01

The radioisotope thermoelectric generator (RTG) that will supply power for the Galileo and Ulysses space missions contains 18 General-Purpose Heat Source (GPHS) modules. The GPHS modules provide power by transmitting the heat of 238 Pu α-decay to an array of thermoelectric elements. Each module contains four 238 PuO 2 -fueled clads and generates 250 W(t). Because the possibility of a launch vehicle explosion always exists, and because such an explosion could generate a field of high-energy fragments, the fueled clads within each GPHS module must survive fragment impact. The edge-on flyer plate tests were included in the Safety Verification Test series to provide information on the module/clad response to the impact of high-energy plate fragments. The test results indicate that the edge-on impact of a 3.2-mm-thick, aluminum-alloy (2219-T87) plate traveling at 915 m/s causes the complete release of fuel from capsules contained within a bare GPHS module, and that the threshold velocity sufficient to cause the breach of a bare, simulant-fueled clad impacted by a 3.5-mm-thick, aluminum-alloy (5052-T0) plate is approximately 140 m/s

General-Purpose Heat Source development: Safety Verification Test Program. Bullet/fragment test series

Energy Technology Data Exchange (ETDEWEB)

George, T.G.; Tate, R.E.; Axler, K.M.

1985-05-01

The radioisotope thermoelectric generator (RTG) that will provide power for space missions contains 18 General-Purpose Heat Source (GPHS) modules. Each module contains four /sup 238/PuO/sub 2/-fueled clads and generates 250 W/sub (t)/. Because a launch-pad or post-launch explosion is always possible, we need to determine the ability of GPHS fueled clads within a module to survive fragment impact. The bullet/fragment test series, part of the Safety Verification Test Plan, was designed to provide information on clad response to impact by a compact, high-energy, aluminum-alloy fragment and to establish a threshold value of fragment energy required to breach the iridium cladding. Test results show that a velocity of 555 m/s (1820 ft/s) with an 18-g bullet is at or near the threshold value of fragment velocity that will cause a clad breach. Results also show that an exothermic Ir/Al reaction occurs if aluminum and hot iridium are in contact, a contact that is possible and most damaging to the clad within a narrow velocity range. The observed reactions between the iridium and the aluminum were studied in the laboratory and are reported in the Appendix.

Development of general-purpose software to analyze the static thermal characteristic of nuclear power plant

International Nuclear Information System (INIS)

Nakao, Yoshinobu; Koda, Eiichi; Takahashi, Toru

2009-01-01

We have developed the general-purpose software by which static thermal characteristic of the power generation system is analyzed easily. This software has the notable features as follows. It has the new algorithm to solve non-linear simultaneous equations to analyze the static thermal characteristics such as heat and mass balance, efficiencies, etc. of various power generation systems. It has the flexibility for setting calculation conditions. It is able to be executed on the personal computer easily and quickly. We ensured that it is able to construct heat and mass balance diagrams of main steam system of nuclear power plant and calculate the power output and efficiencies of the system. Furthermore, we evaluated various heat recovery measures of steam generator blowdown water and found that this software could be a useful operation aid for planning effective changes in support of power stretch. (author)

Is Generalized Maternal Optimism or Pessimism During Pregnancy Associated with Unplanned Cesarean Section Deliveries in China?

Directory of Open Access Journals (Sweden)

Cheryl A. Moyer

2010-01-01

Full Text Available This research examines whether maternal optimism/pessimism is associated with unplanned Cesarean section deliveries in China. If so, does the association remain after controlling for clinical factors associated with C-sections? A sample of 227 mostly primiparous women in the third trimester of pregnancy was surveyed in a large tertiary care hospital in Beijing, China. Post-delivery data were collected from medical records. In bivariate analysis, both optimism and pessimism were related to unplanned c-section. However, when optimism and pessimism were entered into a regression model together, optimism was no longer statistically significant. Pessimism remained significant, even when adjusting for clinical factors such as previous abortion, previous miscarriage, pregnancy complications, infant gestational age, infant birthweight, labor duration, birth complications, and self-rated difficulty of the pregnancy. This research suggests that maternal mindset during pregnancy has a role in mode of delivery. However, more research is needed to elucidate potential causal pathways and test potential interventions.

Nondestructive inspection of General Purpose Heat Source (GPHS) fueled clad girth welds

International Nuclear Information System (INIS)

Reimus, M. A. H.; George, T. G.; Lynch, C.; Padilla, M.; Moniz, P.; Guerrero, A.; Moyer, M. W.; Placr, A.

1998-01-01

The General-Purpose Heat Source (GPHS) provides power for space missions by transmitting the heat of 238 Pu decay to an array of thermoelectric elements. The GPHS is fabricated using an iridium-alloy to contain the 238 PuO 2 fuel pellet. GPHS capsules will be utilized in the upcoming Cassini mission to explore Saturn and its moons. The physical integrity of the girth weld is important to mission safety and performance. Because past experience had revealed a potential for initiation of small cracks in the girth weld overlap zone, a nondestructive inspection of each capsule weld is required. An ultrasonic method was used to inspect the welds of capsules fabricated for the Galileo mission. The instrument, transducer, and method used were state of the art at the time (early 1980s). The ultrasonic instrumentation and methods used to inspect the Cassini GPHSs was significantly upgraded from those used for the Galileo mission. GPHSs that had ultrasonic reflectors in excess of the reject specification level were subsequently inspected with radiography to provide additional engineering data used to accept/reject the heat source. This paper describes the Galileo-era ultrasonic instrumentation and methods and the subsequent upgrades made to support testing of Cassini GPHSs. Also discussed is the data obtained from radiographic examination and correlation to ultrasonic examination results

Nondestructive inspection of General Purpose Heat Source (GPHS) fueled clad girth welds

International Nuclear Information System (INIS)

Reimus, M.A.; George, T.G.; Lynch, C.; Padilla, M.; Moniz, P.; Guerrero, A.; Moyer, M.W.; Placr, A.

1998-01-01

The General-Purpose Heat Source (GPHS) provides power for space missions by transmitting the heat of 238 Pu decay to an array of thermoelectric elements. The GPHS is fabricated using an iridium-alloy to contain the 238 PuO 2 fuel pellet. GPHS capsules will be utilized in the upcoming Cassini mission to explore Saturn and its moons. The physical integrity of the girth weld is important to mission safety and performance. Because past experience had revealed a potential for initiation of small cracks in the girth weld overlap zone, a nondestructive inspection of each capsule weld is required. An ultrasonic method was used to inspect the welds of capsules fabricated for the Galileo mission. The instrument, transducer, and method used were state of the art at the time (early 1980s). The ultrasonic instrumentation and methods used to inspect the Cassini GPHSs was significantly upgraded from those used for the Galileo mission. GPHSs that had ultrasonic reflectors in excess of the reject specification level were subsequently inspected with radiography to provide additional engineering data used to accept/reject the heat source. This paper describes the Galileo-era ultrasonic instrumentation and methods and the subsequent upgrades made to support testing of Cassini GPHSs. Also discussed is the data obtained from radiographic examination and correlation to ultrasonic examination results. copyright 1998 American Institute of Physics

Towards a project-based service delivery approach : Uncovering organisational tensions

OpenAIRE

12330841 - Van der Waldt, Gerrit

2009-01-01

In line with the modernizing, re-inventing and alternative service delivery paradigm, governments increasingly utilise project-based methodologies to improve service delivery. There is general agreement that projects are becoming increasingly important for government institutions to operationalise strategic objectives and policy programmes. This approach is commonly known as ‗Management-by-Projects‘. To adopt this approach requires of public institutions to adjust their existing structures...

Novel electric power-driven hydrodynamic injection system for gene delivery: safety and efficacy of human factor IX delivery in rats.

Science.gov (United States)

Yokoo, T; Kamimura, K; Suda, T; Kanefuji, T; Oda, M; Zhang, G; Liu, D; Aoyagi, Y

2013-08-01

The development of a safe and reproducible gene delivery system is an essential step toward the clinical application of the hydrodynamic gene delivery (HGD) method. For this purpose, we have developed a novel electric power-driven injection system called the HydroJector-EM, which can replicate various time-pressure curves preloaded into the computer program before injection. The assessment of the reproducibility and safety of gene delivery system in vitro and in vivo demonstrated the precise replication of intravascular time-pressure curves and the reproducibility of gene delivery efficiency. The highest level of luciferase expression (272 pg luciferase per mg of proteins) was achieved safely using the time-pressure curve, which reaches 30 mm Hg in 10 s among various curves tested. Using this curve, the sustained expression of a therapeutic level of human factor IX protein (>500 ng ml(-1)) was maintained for 2 months after the HGD of the pBS-HCRHP-FIXIA plasmid. Other than a transient increase in liver enzymes that recovered in a few days, no adverse events were seen in rats. These results confirm the effectiveness of the HydroJector-EM for reproducible gene delivery and demonstrate that long-term therapeutic gene expression can be achieved by automatic computer-controlled hydrodynamic injection that can be performed by anyone.

NMR characterisation and transdermal drug delivery potential of microemulsion systems

DEFF Research Database (Denmark)

Kreilgaard, Mads; Pedersen, E J; Jaroszewski, J W

2000-01-01

The purpose of this study was to investigate the influence of structure and composition of microemulsions (Labrasol/Plurol Isostearique/isostearylic isostearate/water) on their transdermal delivery potential of a lipophilic (lidocaine) and a hydrophilic model drug (prilocaine hydrochloride), and ...

20 CFR 401.155 - Law enforcement purposes.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Law enforcement purposes. 401.155 Section 401... INFORMATION Disclosure of Official Records and Information § 401.155 Law enforcement purposes. (a) General. The Privacy Act allows us to disclose information for law enforcement purposes under certain...

A case of vesicouterine fistula after cesarean section with delivery through the bladder

DEFF Research Database (Denmark)

Schroeder, T; Kristensen, J K

1983-01-01

We report a case of a vesicouterine fistula subsequent to delivery at cesarean section through the bladder. A first attempt to close the fistula failed but a second operation adhering to the general principles of fistula repair was successful.......We report a case of a vesicouterine fistula subsequent to delivery at cesarean section through the bladder. A first attempt to close the fistula failed but a second operation adhering to the general principles of fistula repair was successful....

CLOUDCLOUD : general-purpose instrument monitoring and data managing software

Science.gov (United States)

Dias, António; Amorim, António; Tomé, António

2016-04-01

An effective experiment is dependent on the ability to store and deliver data and information to all participant parties regardless of their degree of involvement in the specific parts that make the experiment a whole. Having fast, efficient and ubiquitous access to data will increase visibility and discussion, such that the outcome will have already been reviewed several times, strengthening the conclusions. The CLOUD project aims at providing users with a general purpose data acquisition, management and instrument monitoring platform that is fast, easy to use, lightweight and accessible to all participants of an experiment. This work is now implemented in the CLOUD experiment at CERN and will be fully integrated with the experiment as of 2016. Despite being used in an experiment of the scale of CLOUD, this software can also be used in any size of experiment or monitoring station, from single computers to large networks of computers to monitor any sort of instrument output without influencing the individual instrument's DAQ. Instrument data and meta data is stored and accessed via a specially designed database architecture and any type of instrument output is accepted using our continuously growing parsing application. Multiple databases can be used to separate different data taking periods or a single database can be used if for instance an experiment is continuous. A simple web-based application gives the user total control over the monitored instruments and their data, allowing data visualization and download, upload of processed data and the ability to edit existing instruments or add new instruments to the experiment. When in a network, new computers are immediately recognized and added to the system and are able to monitor instruments connected to them. Automatic computer integration is achieved by a locally running python-based parsing agent that communicates with a main server application guaranteeing that all instruments assigned to that computer are

A damage mechanics based general purpose interface/contact element

Science.gov (United States)

Yan, Chengyong

laboratory test data presented in the literature. The results demonstrate that the proposed element and the damage law perform very well. The most important scientific contribution of this dissertation is the proposed damage criterion based on second law of thermodynamic and entropy of the system. The proposed general purpose interface/contact element is another contribution of this research. Compared to the previous adhoc interface elements proposed in the literature, the new one is, much more powerful and includes creep, plastic deformations, sliding, temperature, damage, cyclic behavior and fatigue life in a unified formulation.

Animal models for evaluation of oral delivery of biopharmaceuticals

DEFF Research Database (Denmark)

Harloff-Helleberg, Stine; Nielsen, Line Hagner; Nielsen, Hanne Mørck

2017-01-01

of systems for oral delivery of biopharmaceuticals may result in new treatment modalities to increase the patient compliance and reduce product cost. In the preclinical development phase, use of experimental animal models is essential for evaluation of new formulation designs. In general, the limited oral...... bioavailability of biopharmaceuticals, of just a few percent, is expected, and therefore, the animal models and the experimental settings must be chosen with utmost care. More knowledge and focus on this topic is highly needed, despite experience from the numerous studies evaluating animal models for oral drug...... delivery of small molecule drugs. This review highlights and discusses pros and cons of the most currently used animal models and settings. Additionally, it also looks into the influence of anesthetics and sampling methods for evaluation of drug delivery systems for oral delivery of biopharmaceuticals...

Anal incontinence after two vaginal deliveries without obstetric anal sphincter rupture

DEFF Research Database (Denmark)

Persson, Lisa K G; Sakse, Abelone; Langhoff-Roos, Jens

2017-01-01

PURPOSE: To evaluate prevalence and risk factors for long-term anal incontinence in women with two prior vaginal deliveries without obstetric anal sphincter injury (OASIS) and to assess the impact of anal incontinence-related symptoms on quality of life. METHODS: This is a nation-wide cross......-sectional survey study. One thousand women who had a first vaginal delivery and a subsequent delivery, both without OASIS, between 1997 and 2008 in Denmark were identified in the Danish Medical Birth Registry. Women with more than two deliveries in total till 2012 were excluded at this stage. Of the 1000 women...... affected their quality of life. No maternal or obstetric factors including episiotomy and vacuum extraction were consistently associated with altered risk of anal incontinence in the multivariable analyses. CONCLUSIONS: Anal incontinence and fecal urgency is reported by one fifth of women with two vaginal...

5 CFR 841.701 - Purpose and scope.

Science.gov (United States)

2010-01-01

... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Cost-of-Living Adjustments § 841.701 Purpose and scope. (a) The purpose of this subpart is to regulate computation of cost-of-living...

33 CFR 142.81 - Purpose and applicability.

Science.gov (United States)

2010-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH General Workplace Conditions § 142.81 Purpose and applicability. This subpart prescribes requirements relating to general working conditions on...

Multi-Course Comparison of Traditional versus Web-based Course Delivery Systems

Directory of Open Access Journals (Sweden)

J. Michael Weber, PhD.,

2007-07-01

Full Text Available The purpose of this paper is to measure and compare the effectiveness of a Web-based course delivery system to a traditional course delivery system. The results indicate that a web-based course is effective and equivalent to a traditional classroom environment. As with the implementation of all new technologies, there are some pros and cons that should be considered. The significant pro is the element of convenience which eliminates the constrictive boundaries of space and time. The most notable con involves the impersonal nature of the online environment. Overall, we found the web-based course delivery system to be very successful in terms of learning outcomes and student satisfaction.

Perceptions of International Students on Service Quality Delivery in a Malaysian Public University

Science.gov (United States)

Njie, Baboucarr; Asimiran, Soaib; Baki, Roselan

2012-01-01

Purpose: The purpose of this study is to explore the perceptions of international students of service quality delivery (SQD) in a Malaysian public university. Design/methodology/approach: The study was limited to the University's immediate physical environment and its associated human and systems-based services. The physical environment in this…

Factors contributing to low institutional deliveries in the Marondera district of Zimbabwe

Directory of Open Access Journals (Sweden)

E Mugweni

2008-09-01

Full Text Available The purpose of the study was to identify factors contributing to low institutional deliveries in the Marondera District, Zimbabwe, among women who attended antenatal clinics, in order to enhance the number of institutional deliveries. A quantitative descriptive survey, gathering data by conducting structured interviews with 80 women, was used in this study. All 80 women attended ante-natal clinics but 40 delivered at home and 40 delivered at an institution.

Elastin-Like Recombinamers As Smart Drug Delivery Systems.

Science.gov (United States)

Arias, F Javier; Santos, Mercedes; Ibanez-Fonseca, Arturo; Pina, Maria Jesus; Serrano, Sofía

2018-02-19

Drug delivery systems that are able to control the release of bioactive molecules and designed to carry drugs to target sites are of particular interest for tissue therapy. Moreover, systems comprising materials that can respond to environmental stimuli and promote self-assembly and higher order supramolecular organization are especially useful in the biomedical field. Objetive: This review focuses on biomaterials suitable for this purpose and that include elastin-like recombinamers (ELRs), a class of proteinaceous polymers bioinspired by natural elastin, designed using recombinant technologies. The self-assembly and thermoresponsive behaviour of these systems, along with their biodegradability, biocompatibility and well-defined composition as a result of their tailormade design, make them particularly attractive for controlled drug delivery. ELR-based delivery systems that allow targeted delivery are reviewed, especially ELR-drug recombinant fusion constructs, ELR-drug systems chemically bioconjugated in their monomeric and soluble forms, and drug encapsulation by nanoparticle-forming ELRs. Subsequently, the review focuses on those drug carriers in which smart release is triggered by pH or temperature with a particular focus on cancer treatments. Systems for controlled drug release based on depots and hydrogels that act as both a support and reservoir in which drugs can be stored will be described, and their applications in drug delivery discussed. Finally, smart drug-delivery systems not based on ELRs, including those comprising proteins, synthetic polymers and non-polymeric systems, will also be briefly discussed. Several different constructions based on ELRs are potential candidates for controlled drug delivery to be applied in advanced biomedical treatments. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Biocompatibility of Chitosan Carriers with Application in Drug Delivery

Directory of Open Access Journals (Sweden)

Ana Grenha

2012-09-01

Full Text Available Chitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and micron-sized particles. In addition to its interesting physicochemical and biopharmaceutical properties, which include high mucoadhesion and a great capacity to produce drug delivery systems, ensuring the biocompatibility of the drug delivery vehicles is a highly relevant issue. Nevertheless, this subject is not addressed as frequently as desired and even though the application of chitosan carriers has been widely explored, the demonstration of systems biocompatibility is still in its infancy. In this review, addressing the biocompatibility of chitosan carriers with application in drug delivery is discussed and the methods used in vitro and in vivo, exploring the effect of different variables, are described. We further provide a discussion on the pros and cons of used methodologies, as well as on the difficulties arising from the absence of standardization of procedures.

Delivery presentations

Science.gov (United States)

Pregnancy - delivery presentation; Labor - delivery presentation; Occiput posterior; Occiput anterior; Brow presentation ... The mother can walk, rock, and try different delivery positions during labor to help encourage the baby ...

Patient Involvement in Safe Delivery: A Qualitative Study.

Science.gov (United States)

Olfati, Forozun; Asefzadeh, Saeid; Changizi, Nasrin; Keramat, Afsaneh; Yunesian, Masud

2015-09-28

Patient involvement in safe delivery planning is considered important yet not widely practiced. The present study aimed at identifythe factors that affect patient involvementin safe delivery, as recommended by parturient women. This study was part of a qualitative research conducted by content analysis method and purposive sampling in 2013.The data were collected through 63 semi-structured interviews in4 hospitalsand analyzed using thematic content analysis. The participants in this research were women before discharge and after delivery. Findings were analyzed using Colaizzi's method. Four categories of factors that could affect patient involvement in safe delivery emerged from our analysis: patient-related (true and false beliefs, literacy, privacy, respect for patient), illness-related (pain, type of delivery, patient safety incidents), health care professional-relatedand task-related factors (behavior, monitoring &training), health care setting-related (financial aspects, facilities). More research is needed to explore the factors affecting the participation of mothers. It is therefore, recommended to: 1) take notice of mother education, their husbands, midwives and specialists; 2) provide pregnant women with insurance coverage from the outset of pregnancy, especially during prenatal period; 3) form a labor pain committee consisting of midwives, obstetricians, and anesthesiologists in order to identify the preferred painless labor methods based on the existing facilities and conditions, 4) carry out research on observing patients' privacy and dignity; 5) pay more attention on the factors affecting cesarean.

Older individuals' experiences during the assistive technology device service delivery process.

Science.gov (United States)

Gramstad, Astrid; Storli, Sissel Lisa; Hamran, Torunn

2014-07-01

Providing assistive technology devices to older individuals living in their ordinary homes is an important intervention to increase and sustain independence and to enable ageing at home. However, little is known about older individuals' experiences and needs in the assistive technology device (ATD) service delivery process. The purpose of this study was to investigate older individuals' experiences during the service delivery process of ATDs. Nine older individuals were interviewed three times each throughout the ATD service delivery process. The interviews were analysed within a hermeneutical phenomenological perspective. The results show that the service delivery process could be interpreted as an enigmatic journey and described using four themes: "hope and optimistic expectations", "managing after delivery or needing additional help", "having available help versus being abandoned", and "taking charge or putting up". The results emphasize the need for occupational therapists to maintain an individualized approach towards older clients throughout the service delivery process. The experiences of older individuals were diverse and related to expectations that were not necessarily articulated to the occupational therapist. The situation when the ATD is delivered to the client was highlighted by the clients as an important event with the potential to facilitate a successful service delivery process.

Influences of Teacher Delivery, Student Engagement, and Observation Focus on Preservice Teachers' Perceptions of Teaching Effectiveness

Science.gov (United States)

Napoles, Jessica; MacLeod, Rebecca B.

2016-01-01

The purpose of this study was to examine how teacher delivery, student engagement, and observation focus influenced preservice teachers' ratings of teaching effectiveness. Participants (N = 84 preservice teachers) viewed short teaching excerpts of orchestral and choral rehearsals wherein the teacher displayed either high or low teacher delivery,…

Studies related to antibody-mediated boron delivery for BNCT

International Nuclear Information System (INIS)

Hawthorne, M.F.; Varadarajan, A.; Paxton, R.J.; Beatty, B.G.; Curtis, F.L.

1992-01-01

Of the many methods of selective boron delivery to tumor presently under consideration the use of boron-labeled tumor-targeted monoclonal antibodies (Mabs) and their immunoreactive fragments appears to offer the most general, but complex, approach. Assuming that tumor cells generally carry 10 6 characteristic antigenic sites of any one type and that there are approximately 10 9 cells per gram of tumor, one calculates that about 600 10 B atoms must be attached to each individual Mab molecule (if all antigenic sites are complexed) for each 10 ppm of 10 B supplied to tumor. Rather than randomly attack IgG Mab molecules with a large number of relatively small boron-containing conjugation reagent molecules the authors have chosen to assemble a series of discrete, precisely synthesized oligomeric reagents ('trailers') each of which contains a fixed number of B-atoms up to approximately 200. These oligomeric reagents would carry a radioactive or fluorescent group for analytical purposes attached to a terminal-NH 2 group of their chain and the remaining -COOH terminus would be free for conjugation with the lysine var-epsilon-NH 2 groups of Mab protein. Two types of oligomeric trailer reagents are envisioned; hydrophilic peptides and polyamides

Evaluation and characterization of General Purpose Heat Source girth welds for the Cassini mission

International Nuclear Information System (INIS)

Lynch, C.M.; Moniz, P.F.; Reimus, M.A.H.

1998-01-01

General Purpose Heat Sources (GPHSs) are components of Radioisotopic thermoelectric Generators (RTGs) which provide electric power for deep space missions. Each GPHS consists of a 238 Pu oxide ceramic pellet encapsulated in a welded iridium alloy shell which forms a protective barrier against the release of plutonia in the unlikely event of a launch-pad failure or reentry incident. GPHS fueled clad girth weld flaw detection was paramount to ensuring this safety function, and was accomplished using both destructive and non-destructive evaluation techniques. The first girth weld produced from each welding campaign was metallographically examined for flaws such as incomplete weld penetration, cracks, or porosity which would render a GPHS unacceptable for flight applications. After an acceptable example weld was produced, the subsequently welded heat sources were evaluated non-destructively for flaws using ultrasonic immersion testing. Selected heat sources which failed ultrasonic testing would be radiographed, and/or, destructively evaluated to further characterize and document anomalous indications. Metallography was also performed on impacted heat sources to determine the condition of the welds

Microencapsulation: A promising technique for controlled drug delivery.

Science.gov (United States)

Singh, M N; Hemant, K S Y; Ram, M; Shivakumar, H G

2010-07-01

MICROPARTICLES OFFER VARIOUS SIGNIFICANT ADVANTAGES AS DRUG DELIVERY SYSTEMS, INCLUDING: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage forms, such as macro-sized implants), and (iv) Desired, pre-programmed drug release profiles can be provided which match the therapeutic needs of the patient. This article gives an overview on the general aspects and recent advances in drug-loaded microparticles to improve the efficiency of various medical treatments. An appropriately designed controlled release drug delivery system can be a foot ahead towards solving problems concerning to the targeting of drug to a specific organ or tissue, and controlling the rate of drug delivery to the target site. The development of oral controlled release systems has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of gastrointestinal tract. Microparticulate drug delivery systems are an interesting and promising option when developing an oral controlled release system. The objective of this paper is to take a closer look at microparticles as drug delivery devices for increasing efficiency of drug delivery, improving the release profile and drug targeting. In order to appreciate the application possibilities of microcapsules in drug delivery, some fundamental aspects are briefly reviewed.

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

Directory of Open Access Journals (Sweden)

Ndidi C. Ngwuluka

2014-05-01

Full Text Available Naturapolyceutics defines the emerging science and technology platform that blends natural polymers and pharmaceutics for the design and development of drug delivery systems. Natural polymers due to their biological properties, sustainability, chemical flexibility, human and eco-friendliness are promising in this field. As drug delivery advances, there will be need for more polymers. Given that polymers utilized in pharmaceuticals require regulatory approval, robust processes are undertaken to facilitate the production of pharmaceutical grade natural polymers. This review provides insight into the processes—extraction, purification, modifications and characterizations—involved in the eventual utilization of natural polymers for drug delivery. The versatility of natural polymers and particularly modified natural polymers in targeted drug delivery, micro-/nano-drug delivery, theranostics, BioMEMs and generally in research and development of highly efficient, safe and quality products is demonstrated. Natural polymers are polymers of today and tomorrow. Therefore, the shift to undertake training, extensive research and subsequent commercialization of more natural polymers—novel and underutilized—for drug delivery is now!

Connecting drug delivery reality to smart materials design.

Science.gov (United States)

Grainger, David W

2013-09-15

Inflated claims to both design and mechanistic novelty in drug delivery and imaging systems, including most nanotechnologies, are not supported by the generally poor translation of these systems to clinical efficacy. The "form begets function" design paradigm is seductive but perhaps over-simplistic in translation to pharmaceutical efficacy. Most innovations show few clinically important distinctions in their therapeutic benefits in relevant preclinical disease and delivery models, despite frequent claims to the contrary. Long-standing challenges in drug delivery issues must enlist more realistic, back-to-basics approaches to address fundamental materials properties in complex biological systems, preclinical test beds, and analytical methods to more reliably determine fundamental pharmaceutical figures of merit, including drug carrier purity and batch-batch variability, agent biodistribution, therapeutic index (safety), and efficacy. Copyright © 2013 Elsevier B.V. All rights reserved.

Methods and metrics challenges of delivery-system research

Directory of Open Access Journals (Sweden)

Alexander Jeffrey A

2012-03-01

Full Text Available Abstract Background Many delivery-system interventions are fundamentally about change in social systems (both planned and unplanned. This systems perspective raises a number of methodological challenges for studying the effects of delivery-system change--particularly for answering questions related to whether the change will work under different conditions and how the change is integrated (or not into the operating context of the delivery system. Methods The purpose of this paper is to describe the methodological and measurement challenges posed by five key issues in delivery-system research: (1 modeling intervention context; (2 measuring readiness for change; (3 assessing intervention fidelity and sustainability; (4 assessing complex, multicomponent interventions; and (5 incorporating time in delivery-system models to discuss recommendations for addressing these issues. For each issue, we provide recommendations for how research may be designed and implemented to overcome these challenges. Results and conclusions We suggest that a more refined understanding of the mechanisms underlying delivery-system interventions (treatment theory and the ways in which outcomes for different classes of individuals change over time are fundamental starting points for capturing the heterogeneity in samples of individuals exposed to delivery-system interventions. To support the research recommendations outlined in this paper and to advance understanding of the "why" and "how" questions of delivery-system change and their effects, funding agencies should consider supporting studies with larger organizational sample sizes; longer duration; and nontraditional, mixed-methods designs. A version of this paper was prepared under contract with the Agency for Healthcare Research and Quality (AHRQ, US Department of Health and Human Services for presentation and discussion at a meeting on "The Challenge and Promise of Delivery System Research," held in Sterling, VA, on

In vivo dosimetry in intraoperative electron radiotherapy: microMOSFETs, radiochromic films and a general-purpose linac.

Science.gov (United States)

López-Tarjuelo, Juan; Bouché-Babiloni, Ana; Morillo-Macías, Virginia; de Marco-Blancas, Noelia; Santos-Serra, Agustín; Quirós-Higueras, Juan David; Ferrer-Albiach, Carlos

2014-10-01

In vivo dosimetry is desirable for the verification, recording, and eventual correction of treatment in intraoperative electron radiotherapy (IOERT). Our aim is to share our experience of metal oxide semiconductor field-effect transistors (MOSFETs) and radiochromic films with patients undergoing IOERT using a general-purpose linac. We used MOSFETs inserted into sterile bronchus catheters and radiochromic films that were cut, digitized, and sterilized by means of gas plasma. In all, 59 measurements were taken from 27 patients involving 15 primary tumors (seven breast and eight non-breast tumors) and 12 relapses. Data were subjected to an outliers' analysis and classified according to their compatibility with the relevant doses. Associations were sought regarding the type of detector, breast and non-breast irradiation, and the radiation oncologist's assessment of the difficulty of detector placement. At the same time, 19 measurements were carried out at the tumor bed with both detectors. MOSFET measurements ([Formula: see text]  = 93.5 %, sD  =  6.5 %) were not significantly shifted from film measurements ([Formula: see text]  =  96.0 %, sD  =  5.5 %; p  =  0.109), and no associations were found (p = 0.526, p = 0.295,  and p = 0.501, respectively). As regards measurements performed at the tumor bed with both detectors, MOSFET measurements ([Formula: see text]  =  95.0 %, sD  =  5.4 % were not significantly shifted from film measurements ([Formula: see text]  =  96.4 %, sD  =  5.0 %; p  =  0.363). In vivo dosimetry can produce satisfactory results at every studied location with a general-purpose linac. Detector choice should depend on user factors, not on the detector performance itself. Surgical team collaboration is crucial to success.

7 CFR 634.1 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Purpose and scope. 634.1 Section 634.1 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM General § 634.1 Purpose and scope. (a) The purpose... from agricultural activities. The proposed project area must be within a high priority area in an...

50 CFR 85.10 - Purpose and scope.

Science.gov (United States)

2010-10-01

...) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM CLEAN VESSEL ACT GRANT PROGRAM General § 85.10 Purpose and scope. The purpose of this part is to establish requirements for state participation in the... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Purpose and scope. 85.10 Section 85.10...

10 CFR 420.1 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 420.1 Section 420.1 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM General Provisions for State Energy Program Financial Assistance § 420.1 Purpose and scope. It is the purpose of this part to promote the conservation...

Heuristic simulation of nuclear systems on a supercomputer using the HAL-1987 general-purpose production-rule analysis system

International Nuclear Information System (INIS)

Ragheb, M.; Gvillo, D.; Makowitz, H.

1987-01-01

HAL-1987 is a general-purpose tool for the construction of production-rule analysis systems. It uses the rule-based paradigm from the part of artificial intelligence concerned with knowledge engineering. It uses backward-chaining and forward-chaining in an antecedent-consequent logic, and is programmed in Portable Standard Lisp (PSL). The inference engine is flexible and accommodates general additions and modifications to the knowledge base. The system is used in coupled symbolic-procedural programming adaptive methodologies for stochastic simulations. In Monte Carlo simulations of particle transport, the system considers the pre-processing of the input data to the simulation and adaptively controls the variance reduction process as the simulation progresses. This is accomplished through the use of a knowledge base of rules which encompass the user's expertise in the variance reduction process. It is also applied to the construction of model-based systems for monitoring, fault-diagnosis and crisis-alert in engineering devices, particularly in the field of nuclear reactor safety analysis

A randomised trial of the analgesic efficacy of ultrasound-guided transversus abdominis plane block after caesarean delivery under general anaesthesia.

Science.gov (United States)

Tan, Terry T; Teoh, Wendy H L; Woo, David C M; Ocampo, Cecilia E; Shah, Mukesh K; Sia, Alex T H

2012-02-01

Previous studies examining the efficacy of transversus abdominis plane block after caesarean section have mostly been in parturients under spinal anaesthesia. We postulated that the advantage of performing transversus abdominis plane block after caesarean section might be even more obvious after general anaesthesia, resulting in reduced 24-h consumption of morphine. DESIGN, SETTING, PATIENTS AND INTERVENTIONS: In this single centre, randomised double-blind controlled trial, 40 women who underwent caesarean delivery under general anaesthesia were allocated randomly to receive a transversus abdominis plane block or no block. In those who received the block, 20 ml of levobupivacaine 2.5 mg ml was deposited bilaterally into the transversus abdominis plane under ultrasound guidance using a Sonosite Titan (SonoSite, Bothell, Washington, USA) 7-13 MHz linear transducer at the end of surgery when the patient was still anaesthetised. We recorded patient-controlled intravenous morphine use for 24 h, pain scores at rest and activity, sedation, nausea and vomiting, use of antiemetic medication and overall maternal satisfaction. The primary outcome was 24-h morphine consumption. Patients who received the transversus abdominis plane block used significantly less morphine in 24 h than those in the control group [12.3 (2.6) vs. 31.4 mg (3.1), Pplane block reduced morphine consumption following caesarean section under general anaesthesia, with increased maternal satisfaction.

37 CFR 1.315 - Delivery of patent.

Science.gov (United States)

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Delivery of patent. 1.315 Section 1.315 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions Allowance and Issue of...

Regulation on the general conditions of sale and delivery of radioactive materials of the 15th December 1987

International Nuclear Information System (INIS)

1988-01-01

The regulation governing the cooperation between suppliers and customers of radioactive materials was issued by the Ministry of Chemical Industry and entered into force on 1 March 1988. The following articles are covered: definition, contents and form of supply contracts, licensing and registration, quality and labelling, delivery note, transport, terms of delivery, quality control, packaging, and reuse

General Purpose Ground Forces: What Purpose?

National Research Council Canada - National Science Library

Challis, Dan

1993-01-01

"New World Order," a phrase uttered frequently by former President George Bush during and after the Persian Gulf War, no longer connotes the optimism of America's global view at the end of Desert Storm...

10 CFR 4.301 - Purpose and scope.

Science.gov (United States)

2010-01-01

... FINANCIAL ASSISTANCE FROM THE COMMISSION Regulations Implementing the Age Discrimination Act of 1975, as Amended General § 4.301 Purpose and scope. The purpose of this subpart is to set forth NRC policies and... 10 Energy 1 2010-01-01 2010-01-01 false Purpose and scope. 4.301 Section 4.301 Energy NUCLEAR...

Evaluation of Aqueous and Powder Processing Techniques for Production of Pu-238-Fueled General Purpose Heat Sources

Energy Technology Data Exchange (ETDEWEB)

2008-06-01

This report evaluates alternative processes that could be used to produce Pu-238 fueled General Purpose Heat Sources (GPHS) for radioisotope thermoelectric generators (RTG). Fabricating GPHSs with the current process has remained essentially unchanged since its development in the 1970s. Meanwhile, 30 years of technological advancements have been made in the fields of chemistry, manufacturing, ceramics, and control systems. At the Department of Energy’s request, alternate manufacturing methods were compared to current methods to determine if alternative fabrication processes could reduce the hazards, especially the production of respirable fines, while producing an equivalent GPHS product. An expert committee performed the evaluation with input from four national laboratories experienced in Pu-238 handling.

Effects of detector-source distance and detector bias voltage variations on time resolution of general purpose plastic scintillation detectors.

Science.gov (United States)

Ermis, E E; Celiktas, C

2012-12-01

Effects of source-detector distance and the detector bias voltage variations on time resolution of a general purpose plastic scintillation detector such as BC400 were investigated. (133)Ba and (207)Bi calibration sources with and without collimator were used in the present work. Optimum source-detector distance and bias voltage values were determined for the best time resolution by using leading edge timing method. Effect of the collimator usage on time resolution was also investigated. Copyright © 2012 Elsevier Ltd. All rights reserved.

Application of a general purpose user's version of the EGS4 code system to a photon skyshine benchmarking calculation

International Nuclear Information System (INIS)

Nojiri, I.; Fukasaku, Y.; Narita, O.

1994-01-01

A general purpose user's version of the EGS4 code system has been developed to make EGS4 easily applicable to the safety analysis of nuclear fuel cycle facilities. One such application involves the determination of skyshine dose for a variety of photon sources. To verify the accuracy of the code, it was benchmarked with Kansas State University (KSU) photon skyshine experiment of 1977. The results of the simulation showed that this version of EGS4 would be appicable to the skyshine calculation. (author)

MONK - a general purpose Monte Carlo neutronics program

International Nuclear Information System (INIS)

Sherriffs, V.S.W.

1978-01-01

MONK is a Monte Carlo neutronics code written principally for criticality calculations relevant to the transport, storage, and processing of fissile material. The code exploits the ability of the Monte Carlo method to represent complex shapes with very great accuracy. The nuclear data used is derived from the UK Nuclear Data File processed to the required format by a subsidiary program POND. A general description is given of the MONK code together with the subsidiary program SCAN which produces diagrams of the system specified. Details of the data input required by MONK and SCAN are also given. (author)

22 CFR 1203.735-101 - Purpose.

Science.gov (United States)

2010-04-01

... CONDUCT General Provisions § 1203.735-101 Purpose. The maintenance of the highest standards of honesty... reporting employment and financial interests. Note: These regulations are codified in State 3 FAM 620, AID... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Purpose. 1203.735-101 Section 1203.735-101...

12 CFR 1710.1 - Purpose.

Science.gov (United States)

2010-01-01

... minimum standards with respect to the corporate governance practices and procedures of the Enterprises. ... AND SOUNDNESS CORPORATE GOVERNANCE General § 1710.1 Purpose. OFHEO is responsible under the Federal...

Procedures for EPA Libraries to Obtain Materials through Interlibrary Loan/Document Delivery

Science.gov (United States)

The purpose of this document is to establish Agency-wide procedures by which EPA libraries obtain materials for Agency employees and authorized EPA contractors through interlibrary loan (ILL) and other document delivery methods.

Transdermal drug delivery

Science.gov (United States)

Prausnitz, Mark R.; Langer, Robert

2009-01-01

Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin’s barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase impact on medicine. PMID:18997767

Gated Treatment Delivery Verification With On-Line Megavoltage Fluoroscopy

International Nuclear Information System (INIS)

Tai An; Christensen, James D.; Gore, Elizabeth; Khamene, Ali; Boettger, Thomas; Li, X. Allen

2010-01-01

Purpose: To develop and clinically demonstrate the use of on-line real-time megavoltage (MV) fluoroscopy for gated treatment delivery verification. Methods and Materials: Megavoltage fluoroscopy (MVF) image sequences were acquired using a flat panel equipped for MV cone-beam CT in synchrony with the respiratory signal obtained from the Anzai gating device. The MVF images can be obtained immediately before or during gated treatment delivery. A prototype software tool (named RTReg4D) was developed to register MVF images with phase-sequenced digitally reconstructed radiograph images generated from the treatment planning system based on four-dimensional CT. The image registration can be used to reposition the patient before or during treatment delivery. To demonstrate the reliability and clinical usefulness, the system was first tested using a thoracic phantom and then prospectively in actual patient treatments under an institutional review board-approved protocol. Results: The quality of the MVF images for lung tumors is adequate for image registration with phase-sequenced digitally reconstructed radiographs. The MVF was found to be useful for monitoring inter- and intrafractional variations of tumor positions. With the planning target volume contour displayed on the MVF images, the system can verify whether the moving target stays within the planning target volume margin during gated delivery. Conclusions: The use of MVF images was found to be clinically effective in detecting discrepancies in tumor location before and during respiration-gated treatment delivery. The tools and process developed can be useful for gated treatment delivery verification.

Self-Assembled Lipid Nanoparticles for Oral Delivery of Heparin-Coated Iron Oxide Nanoparticles for Theranostic Purposes.

Science.gov (United States)

Truzzi, Eleonora; Bongio, Chiara; Sacchetti, Francesca; Maretti, Eleonora; Montanari, Monica; Iannuccelli, Valentina; Vismara, Elena; Leo, Eliana

2017-06-09

Recently, solid lipid nanoparticles (SLNs) have attracted increasing attention owing to their potential as an oral delivery system, promoting intestinal absorption in the lymphatic circulation which plays a role in disseminating metastatic cancer cells and infectious agents throughout the body. SLN features can be exploited for the oral delivery of theranostics. Therefore, the aim of this work was to design and characterise self-assembled lipid nanoparticles (SALNs) to encapsulate and stabilise iron oxide nanoparticles non-covalently coated with heparin (Fe@hepa) as a model of a theranostic tool. SALNs were characterised for physico-chemical properties (particle size, surface charge, encapsulation efficiency, in vitro stability, and heparin leakage), as well as in vitro cytotoxicity by methyl thiazole tetrazolium (MTT) assay and cell internalisation in CaCo-2, a cell line model used as an indirect indication of intestinal lymphatic absorption. SALNs of about 180 nm, which are stable in suspension and have a high encapsulation efficiency (>90%) were obtained. SALNs were able to stabilise the heparin coating of Fe@hepa, which are typically unstable in physiological environments. Moreover, SALNs-Fe@hepa showed no cytotoxicity, although their ability to be internalised into CaCo-2 cells was highlighted by confocal microscopy analysis. Therefore, the results indicated that SALNs can be considered as a promising tool to orally deliver theranostic Fe@hepa into the lymphatic circulation, although further in vivo studies are needed to comprehend further potential applications.

Immunization delivery in British Columbia

Science.gov (United States)

Omura, John; Buxton, Jane; Kaczorowski, Janusz; Catterson, Jason; Li, Jane; Derban, Andrea; Hasselback, Paul; Machin, Shelagh; Linekin, Michelle; Morgana, Tamsin; O’Briain, Barra; Scheifele, David; Dawar, Meena

2014-01-01

Abstract Objective To explore the experiences of family physicians and pediatricians delivering immunizations, including perceived barriers and supports. Design Qualitative study using focus groups. Setting Ten cities throughout British Columbia. Participants A total of 46 family physicians or general practitioners, 10 pediatricians, and 2 residents. Methods A semistructured dialogue guide was used by a trained facilitator to explore participants’ experiences and views related to immunization delivery in British Columbia. Verbatim transcriptions were independently coded by 2 researchers. Key themes were analyzed and identified in an iterative manner using interpretive description. Main findings Physicians highly valued vaccine delivery. Factors facilitating physician-delivered immunizations included strong beliefs in the value of vaccines and having adequate information. Identified barriers included the large time commitment and insufficient communication about program changes, new vaccines, and the adult immunization program in general. Some physicians reported good relationships with local public health, while others reported the opposite experience, and this varied by geographic location. Conclusion These findings suggest that physicians are supportive of delivering vaccines. However, there are opportunities to improve the sustainability of physician-delivered immunizations. While compensation schemes remain under the purview of the provincial governments, local public health authorities can address the information needs of physicians. PMID:24627403

Assisted Vaginal Delivery

Science.gov (United States)

... Education & Events Advocacy For Patients About ACOG Assisted Vaginal Delivery Home For Patients Search FAQs Assisted Vaginal ... Vaginal Delivery FAQ192, February 2016 PDF Format Assisted Vaginal Delivery Labor, Delivery, and Postpartum Care What is ...

Polysaccharide-based Noncovalent Assembly for Targeted Delivery of Taxol

Science.gov (United States)

Yang, Yang; Zhang, Ying-Ming; Chen, Yong; Chen, Jia-Tong; Liu, Yu

2016-01-01

The construction of synthetic straightforward, biocompatible and biodegradable targeted drug delivery system with fluorescent tracking abilities, high anticancer activities and low side effects is still a challenge in the field of biochemistry and material chemistry. In this work, we constructed targeted paclitaxel (Taxol) delivery nanoparticles composed of permethyl-β-cyclodextrin modified hyaluronic acid (HApCD) and porphyrin modified paclitaxel prodrug (PorTaxol), through host-guest and amphiphilic interactions. The obtained nanoparticles (HATXP) were biocompatible and enzymatic biodegradable due to their hydrophilic hyaluronic acid (HA) shell and hydrophobic Taxol core, and exhibited specific targeting internalization into cancer cells via HA receptor mediated endocytosis effects. The cytotoxicity experiments showed that the HATXP exhibited similar anticancer activities to, but much lower side effects than commercial anticancer drug Taxol. The present work would provide a platform for targeted paclitaxel drug delivery and a general protocol for the design of advanced multifunctional nanoscale biomaterials for targeted drug/gene delivery.

Delivery by Cesarean Section is not Associated With Decreased at-Birth Fracture Rates in Osteogenesis Imperfecta

Science.gov (United States)

Bellur, S; Jain, M; Cuthbertson, D; Krakow, D; Shapiro, JR; Steiner, RD; Smith, PA; Bober, MB; Hart, T; Krischer, J; Mullins, M; Byers, PH; Pepin, M; Durigova, M; Glorieux, FH; Rauch, F; Sutton, VR; Lee, B; Nagamani, SC

2015-01-01

Purpose Osteogenesis imperfecta (OI) predisposes to recurrent fractures. The moderate-to-severe forms of OI present with antenatal fractures and the mode of delivery that would be safest for the fetus is not known. Methods We conducted systematic analyses on the largest cohort of individuals (n=540) with OI enrolled to-date in the OI Linked Clinical Research Centers. Self-reported at-birth fracture rates were compared in individuals with OI types I, III, and IV. Multivariate analyses utilizing backward-elimination logistic regression model building were performed to assess the effect of multiple covariates including method of delivery on fracture-related outcomes. Results When accounting for other covariates, at-birth fracture rates did not differ based on whether delivery was by vaginal route or by cesarean section (CS). Increased birth weight conferred higher risk for fractures irrespective of the delivery method. In utero fracture, maternal history of OI, and breech presentation were strong predictors for choosing CS for delivery. Conclusion Our study, the largest to analyze the effect of various factors on at-birth fracture rates in OI shows that delivery by CS is not associated with decreased fracture rate. With the limitation that the fracture data were self-reported in this cohort, these results suggest that CS should be performed only for other maternal or fetal indications, but not for the sole purpose of fracture prevention in OI. PMID:26426884

45 CFR 73.735-101 - Purpose.

Science.gov (United States)

2010-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION STANDARDS OF CONDUCT General Provisions § 73.735-101 Purpose. To assure that the business of the Department of Health and Human Services... responsibilities. In accord with these principles, the regulations in this part are issued to inform HHS employees...

A Comparative Analysis of the Environmental Benefits of Drone-Based Delivery Services in Urban and Rural Areas

OpenAIRE

Jiyoon Park; Solhee Kim; Kyo Suh

2018-01-01

Unmanned aerial vehicles (UAV, drones) used as delivery vehicles have received increasing attention due to their mobility and accessibility to remote areas. The purpose of this study is to evaluate the environmental impacts of drone versus motorcycle delivery and to compare the expected environmental improvements due to drone delivery in urban and rural areas. In addition, the potential environmental contributions of electric motorcycles were assessed to determine the effects of introducing t...

15 CFR 8b.1 - Purpose.

Science.gov (United States)

2010-01-01

... of handicap in any program or activity receiving Federal financial assistance. The purpose of this... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Purpose. 8b.1 Section 8b.1 Commerce... HANDICAPPED IN FEDERALLY ASSISTED PROGRAMS OPERATED BY THE DEPARTMENT OF COMMERCE General Provisions § 8b.1...

Development of a General-Purpose Analysis System Based on a Programmable Fluid Processor Final Report CRADA No. TC-2027-01

Energy Technology Data Exchange (ETDEWEB)

McConaghy, C. F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gascoyne, P. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-09-28

The purpose ofthis project was to develop a general-purpose analysis system based on a programmable fluid processor (PFP). The PFP is an array of electrodes surrounded by fluid reservoirs and injectors. Injected droplets of various reagents are manjpulated and combined on the array by Dielectrophoretic (DEP) forces. The goal was to create a small handheld device that could accomplish the tasks currently undertaken by much larger, time consuming, manual manipulation in the lab. The entire effo1t was funded by DARPA under the Bio-Flips program. MD Anderson Cancer Center was the PI for the DARPA effort. The Bio-Flips program was a 3- year program that ran from September 2000 to September 2003. The CRADA was somewhat behind the Bi-Flips program running from June 2001 to June 2004 with a no cost extension to September 2004.

Communicative Purpose as Genre Determinant

DEFF Research Database (Denmark)

Askehave, Inger

1999-01-01

Through the years researchers and LSP teachers alike have used various parameters for classifying texts. This article sets out to discuss the notion of "communicative purpose" as a means for classifying text. It points to some of the difficulties associated with the functional approaches to genre...... classification in general and the notion of "communicative purpose" in particular.......Through the years researchers and LSP teachers alike have used various parameters for classifying texts. This article sets out to discuss the notion of "communicative purpose" as a means for classifying text. It points to some of the difficulties associated with the functional approaches to genre...

Generic project definitions for improvement of health care delivery: a case-based approach.

Science.gov (United States)

Niemeijer, Gerard C; Does, Ronald J M M; de Mast, Jeroen; Trip, Albert; van den Heuvel, Jaap

2011-01-01

The purpose of this article is to create actionable knowledge, making the definition of process improvement projects in health care delivery more effective. This study is a retrospective analysis of process improvement projects in hospitals, facilitating a case-based reasoning approach to project definition. Data sources were project documentation and hospital-performance statistics of 271 Lean Six Sigma health care projects from 2002 to 2009 of general, teaching, and academic hospitals in the Netherlands and Belgium. Objectives and operational definitions of improvement projects in the sample, analyzed and structured in a uniform format and terminology. Extraction of reusable elements of earlier project definitions, presented in the form of 9 templates called generic project definitions. These templates function as exemplars for future process improvement projects, making the selection, definition, and operationalization of similar projects more efficient. Each template includes an explicated rationale, an operationalization in the form of metrics, and a prototypical example. Thus, a process of incremental and sustained learning based on case-based reasoning is facilitated. The quality of project definitions is a crucial success factor in pursuits to improve health care delivery. We offer 9 tried and tested improvement themes related to patient safety, patient satisfaction, and business-economic performance of hospitals.

Optimization of a truck-drone in tandem delivery network using k-means and genetic algorithm

Directory of Open Access Journals (Sweden)

Sergio Mourelo Ferrandez

2016-04-01

Full Text Available Purpose: The purpose of this paper is to investigate the effectiveness of implementing unmanned aerial delivery vehicles in delivery networks. We investigate the notion of the reduced overall delivery time, energy, and costs for a truck-drone network by comparing the in-tandem system with a stand-alone delivery effort. The objectives are (1 to investigate the time, energy, and costs associated to a truck-drone delivery network compared to standalone truck or drone, (2 to propose an optimization algorithm that determines the optimal number of launch sites and locations given delivery requirements, and drones per truck, (3 to develop mathematical formulations for closed form estimations for the optimal number of launch locations, optimal total time, as well as the associated cost for the system. Design/methodology/approach: The design of the algorithm herein computes the minimal time of delivery utilizing K-means clustering to find launch locations, as well as a genetic algorithm to solve the truck route as a traveling salesmen problem (TSP. The optimal solution is determined by finding the minimum cost associated to the parabolic convex cost function. The optimal min-cost is determined by finding the most efficient launch locations using K-means algorithms to determine launch locations and a genetic algorithm to determine truck route between those launch locations.  Findings: Results show improvements with in-tandem delivery efforts as opposed to standalone systems. Further, multiple drones per truck are more optimal and contribute to savings in both energy and time. For this, we sampled various initialization variables to derive closed form mathematical solutions for the problem. Originality/value: Ultimately, this provides the necessary analysis of an integrated truck-drone delivery system which could be implemented by a company in order to maximize deliveries while minimizing time and energy. Closed-form mathematical solutions can be used as

Improving Service Delivery: Investigating the Role of Information Sharing, Job Characteristics, and Employee Satisfaction

Science.gov (United States)

Bontis, Nick; Richards, David; Serenko, Alexander

2011-01-01

Purpose: The purpose of this study is to propose and test a model designed to investigate the impact of job characteristics, employee satisfaction, and information sharing on two key indicators of quality service delivery, such as worker perceptions of their efficiency and customer focus. Design/methodology/approach: During the project, 9,060…

Self-nanoemulsifying drug delivery systems for oral insulin delivery

DEFF Research Database (Denmark)

Li, Ping; Tan, Angel; Prestidge, Clive A

2014-01-01

This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10% w...

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review

Directory of Open Access Journals (Sweden)

Jiangyu Wu

2013-01-01

Full Text Available RNA interference (RNAi was first literaturally reported in 1998 and has become rapidly a promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small interfering RNAs (siRNA are used to specifically downregulate the expression of the targeted gene, known as the term “gene silencing.” One key point for successful gene silencing is to employ a safe and efficient siRNA delivery system. In this context, dendrimers are emerging as potential nonviral vectors to deliver siRNA for RNAi purpose. Dendrimers have attracted intense interest since their emanating research in the 1980s and are extensively studied as efficient DNA delivery vectors in gene transfer applications, due to their unique features based on the well-defined and multivalent structures. Knowing that DNA and RNA possess a similar structure in terms of nucleic acid framework and the electronegative nature, one can also use the excellent DNA delivery properties of dendrimers to develop effective siRNA delivery systems. In this review, the development of dendrimer-based siRNA delivery vectors is summarized, focusing on the vector features (siRNA delivery efficiency, cytotoxicity, etc. of different types of dendrimers and the related investigations on structure-activity relationship to promote safe and efficient siRNA delivery system.

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review

Science.gov (United States)

Huang, Weizhe; He, Ziying

2013-01-01

RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small interfering RNAs (siRNA) are used to specifically downregulate the expression of the targeted gene, known as the term “gene silencing.” One key point for successful gene silencing is to employ a safe and efficient siRNA delivery system. In this context, dendrimers are emerging as potential nonviral vectors to deliver siRNA for RNAi purpose. Dendrimers have attracted intense interest since their emanating research in the 1980s and are extensively studied as efficient DNA delivery vectors in gene transfer applications, due to their unique features based on the well-defined and multivalent structures. Knowing that DNA and RNA possess a similar structure in terms of nucleic acid framework and the electronegative nature, one can also use the excellent DNA delivery properties of dendrimers to develop effective siRNA delivery systems. In this review, the development of dendrimer-based siRNA delivery vectors is summarized, focusing on the vector features (siRNA delivery efficiency, cytotoxicity, etc.) of different types of dendrimers and the related investigations on structure-activity relationship to promote safe and efficient siRNA delivery system. PMID:24288498

Microneedles for drug and vaccine delivery

Science.gov (United States)

Kim, Yeu-Chun; Park, Jung-Hwan; Prausnitz, Mark R.

2012-01-01

Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990’s when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications. PMID:22575858

The effects of the mode of delivery on oxidative-antioxidative balance.

Science.gov (United States)

Mutlu, Birgul; Aksoy, Nurten; Cakir, Hale; Celik, Hakim; Erel, Ozcan

2011-11-01

The purpose of this study was to investigate the effects of the mode of delivery on the oxidant and antioxidant systems in mothers and infants and to demonstrate which mode leads more oxidative stress. The participants were divided into two groups according to the mode of their labour and delivery: group 1 (n = 33) women with normal labour and delivery and group 2 (n = 33) with scheduled caesarean section (C/S) and delivery. The maternal, cord, and infant blood samples in both groups were collected. The serum total antioxidant capacity (TAC) and the total oxidant status (TOS) were evaluated by using an automated colorimetric measurement method. The parameters indicating oxidative stress (TOS, oxidative stress index, and lipid hydroperoxide) in maternal, cord, and newborn blood samples were higher in patients delivering with C/S than those normal spontaneous vaginal deliveries (NSVD) patient group, while it was vice versa for TAC. It may be concluded that both the mothers and neonates in C/S group are exposed to higher oxidative stress as compared with those in NSVD group and the antioxidant mechanisms are insufficient to cope with this stress during C/S. This result indicates that the normal delivery through the physiological route is healthier for the bodies of mothers and infants.

Formulation and evaluation of two-pulse drug delivery system of ...

African Journals Online (AJOL)

Purpose: To develop a pH-controlled two-pulse drug delivery system of amoxicillin in order to overcome the snag of biological tolerance and to improve bactericidal activity. Methods: The core tablets were compressed and coated with hydroxylpropyl methylcellulose (HPMC) of different viscosities with spray-dried lactose ...

Planned and unplanned deliveries at home: implications of a changing ratio.

Science.gov (United States)

Murphy, J F; Dauncey, M; Gray, O P; Chalmers, I

1984-05-12

The observation that perinatal mortality among babies delivered at home has tended to increase beyond that among babies delivered in consultant obstetric units has caused alarm and prompted recommendations that delivery at home should be further phased out. With data derived from the Cardiff Births Survey the possibility was investigated that this trend might reflect a changing ratio of planned to unplanned domiciliary births. At the beginning of the 1970s deliveries at home that were planned to be so outnumbered those that were not by nearly five to one. By 1979 unplanned deliveries at home outnumbered planned deliveries. The characteristics of the mothers, the health care they received, and the outcome of delivery differed strikingly between planned and unplanned deliveries at home. It is concluded, firstly, that every year the maternity services must try to meet the various needs of about 2000 women in England and Wales who give birth at home without planning to do so; and, secondly, that the heterogeneity of births at home and in hospital will continue to obstruct the search for unbiased estimates of the risks attributable to delivery in specialist obstetric units, general practitioner units, and at home.

Transdermal drug delivery

OpenAIRE

Prausnitz, Mark R.; Langer, Robert

2008-01-01

Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability ...

The PennBMBI: Design of a General Purpose Wireless Brain-Machine-Brain Interface System.

Science.gov (United States)

Liu, Xilin; Zhang, Milin; Subei, Basheer; Richardson, Andrew G; Lucas, Timothy H; Van der Spiegel, Jan

2015-04-01

In this paper, a general purpose wireless Brain-Machine-Brain Interface (BMBI) system is presented. The system integrates four battery-powered wireless devices for the implementation of a closed-loop sensorimotor neural interface, including a neural signal analyzer, a neural stimulator, a body-area sensor node and a graphic user interface implemented on the PC end. The neural signal analyzer features a four channel analog front-end with configurable bandpass filter, gain stage, digitization resolution, and sampling rate. The target frequency band is configurable from EEG to single unit activity. A noise floor of 4.69 μVrms is achieved over a bandwidth from 0.05 Hz to 6 kHz. Digital filtering, neural feature extraction, spike detection, sensing-stimulating modulation, and compressed sensing measurement are realized in a central processing unit integrated in the analyzer. A flash memory card is also integrated in the analyzer. A 2-channel neural stimulator with a compliance voltage up to ± 12 V is included. The stimulator is capable of delivering unipolar or bipolar, charge-balanced current pulses with programmable pulse shape, amplitude, width, pulse train frequency and latency. A multi-functional sensor node, including an accelerometer, a temperature sensor, a flexiforce sensor and a general sensor extension port has been designed. A computer interface is designed to monitor, control and configure all aforementioned devices via a wireless link, according to a custom designed communication protocol. Wireless closed-loop operation between the sensory devices, neural stimulator, and neural signal analyzer can be configured. The proposed system was designed to link two sites in the brain, bridging the brain and external hardware, as well as creating new sensory and motor pathways for clinical practice. Bench test and in vivo experiments are performed to verify the functions and performances of the system.

General general game AI

OpenAIRE

Togelius, Julian; Yannakakis, Georgios N.; 2016 IEEE Conference on Computational Intelligence and Games (CIG)

2016-01-01

Arguably the grand goal of artificial intelligence research is to produce machines with general intelligence: the capacity to solve multiple problems, not just one. Artificial intelligence (AI) has investigated the general intelligence capacity of machines within the domain of games more than any other domain given the ideal properties of games for that purpose: controlled yet interesting and computationally hard problems. This line of research, however, has so far focuse...

40 CFR 260.1 - Purpose, scope, and applicability.

Science.gov (United States)

2010-07-01

....1 Section 260.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) HAZARDOUS WASTE MANAGEMENT SYSTEM: GENERAL General § 260.1 Purpose, scope, and applicability. (a) This part provides definitions of terms, general standards, and overview information applicable to...

Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components.

Science.gov (United States)

McClements, David Julian; Li, Yan

2010-09-15

There is a need for edible delivery systems to encapsulate, protect and release bioactive and functional lipophilic constituents within the food and pharmaceutical industries. These delivery systems could be used for a number of purposes: controlling lipid bioavailability; targeting the delivery of bioactive components within the gastrointestinal tract; and designing food matrices that delay lipid digestion and induce satiety. Emulsion technology is particularly suited for the design and fabrication of delivery systems for lipids. In this article we provide an overview of a number of emulsion-based technologies that can be used as edible delivery systems by the food and other industries, including conventional emulsions, nanoemulsions, multilayer emulsions, solid lipid particles, and filled hydrogel particles. Each of these delivery systems can be produced from food-grade (GRAS) ingredients (e.g., lipids, proteins, polysaccharides, surfactants, and minerals) using relatively simple processing operations (e.g., mixing, homogenizing, and thermal processing). The structure, preparation, and utilization of each type of delivery system for controlling lipid digestion are discussed. This knowledge can be used to select the most appropriate emulsion-based delivery system for specific applications, such as encapsulation, controlled digestion, and targeted release. Copyright 2010 Elsevier B.V. All rights reserved.

Proposal of a service delivery integration index of home care for older persons: application in several European cities.

NARCIS (Netherlands)

Henrard, J.C.; Ankri, J.; Frijters, D.; Carpenter, I.; Topinkova, E.; Garms-Homolova, V.; Finne-Soveri, H.; Wergeland Sorbye, L.; Jonsson, P.V.; Ljunggren, G.; Schroll, M.; Wagner, C.; Bernabei, R.

2006-01-01

PURPOSE: To propose an integration index of home care delivery to older persons, to study its validity and to apply it to home care services of European cities. THEORY: Home care delivery integration was based on two dimensions referring to process-centred integration and organisational structure

19 CFR 201.42 - Purpose and scope.

Science.gov (United States)

2010-04-01

... Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION National Security Information § 201.42 Purpose and scope. The following regulation supplements Executive Order 12356, National Security Information, April 2, 1982, as it applies to the Commission. ...

5 CFR 890.1001 - Scope and purpose.

Science.gov (United States)

2010-01-01

... Providers General Provisions and Definitions § 890.1001 Scope and purpose. (a) Scope. This subpart... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Scope and purpose. 890.1001 Section 890... certain violations. The sanctions include debarment, suspension, civil monetary penalties, and financial...

10 CFR 600.500 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Purpose and scope. 600.500 Section 600.500 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Eligibility Determination for Certain Financial Assistance Programs-General Statement of Policy § 600.500 Purpose and scope...

12 CFR 621.1 - Purpose and applicability.

Science.gov (United States)

2010-01-01

... Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ACCOUNTING AND REPORTING REQUIREMENTS Purpose and Definitions § 621.1 Purpose and applicability. This part sets forth accounting and reporting... Mortgage Corporation. The requirements set forth in this part are of both general and specific...

Cultural perceptions and preferences of Iranian women regarding cesarean delivery

Science.gov (United States)

Latifnejad-Roudsari, Robab; Zakerihamidi, Maryam; Merghati-Khoei, Effat; Kazemnejad, Anoshirvan

2014-01-01

Background: Data was reported in Iran in 2013 has shown that almost 42 percent of deliveries in public hospitals and 90 percent in private hospitals were carried out with cesarean section. This high rate of cesarean requires careful consideration. It seems that making decision for cesarean is done under the influence of cultural perceptions and beliefs. So, this study was conducted to explore pregnant women's preferences and perceptions regarding cesarean delivery. Materials and Methods: A focused ethnographic study was used. 12 pregnant women and 10 delivered women, seven midwives, seven gynecologist and nine non-pregnant women referred to the health clinics of Tonekabon, who selected purposively, were included in the study. To collect data semi-structured in-depth interviews and participant observation were used. Study rigor was confirmed through prolonged engagement, member check, expert debriefing, and thick description of the data. Data were analysed using thematic analysis and MAXQDA software. Results: Four themes emerged from the data including personal beliefs, fear of vaginal delivery, cultural norms and values and also social network. These concepts played main roles in how women develop meanings toward caesarean, which affected their perceptions and preferences in relation to caesarean delivery. Conclusion: Most of pregnant women believed that fear of vaginal delivery is a major factor to choose caesarean delivery. Hence, midwives and physicians could help them through improving the quality of prenatal care and giving them positive perception towards vaginal delivery through presenting useful information about the nature of different modes of delivery, and their advantages and disadvantages, as well as the alternative ways to control labor pain. PMID:25949249

Significant role of cationic polymers in drug delivery systems.

Science.gov (United States)

Farshbaf, Masoud; Davaran, Soodabeh; Zarebkohan, Amir; Annabi, Nasim; Akbarzadeh, Abolfazl; Salehi, Roya

2017-11-06

Cationic polymers are characterized as the macromolecules that possess positive charges, which can be either inherently in the polymer side chains and/or its backbone. Based on their origins, cationic polymers are divided in two category including natural and synthetic, in which the possessed positive charges are as result of primary, secondary or tertiary amine functional groups that could be protonated in particular situations. Cationic polymers have been employed commonly as drug delivery agents due to their superior encapsulation efficacy, enhanced bioavailability, low toxicity and improved release profile. In this paper, we focus on the most prominent examples of cationic polymers which have been revealed to be applicable in drug delivery systems and we also discuss their general synthesis and surface modification methods as well as their controlled release profile in drug delivery.

Training Delivery Methods as Source of Dynamic Capabilities: The Case of Sports' Organisations

Science.gov (United States)

Arraya, Marco António Mexia; Porfírio, Jose António

2017-01-01

Purpose: Training as an important source of dynamic capabilities (DC) is important to the performance of sports' organisations (SO) both to athletes and to non-athletic staff. There are a variety of training delivery methods (TDMs). The purpose of this study is to determine from a set of six TDMs which one is considered to be the most suitable to…

Evaluation of Diclofenac Prodrugs for Enhancing Transdermal Delivery

OpenAIRE

Lobo, Shabbir; Li, Henan; Farhan, Nashid; Yan, Guang

2013-01-01

The purpose of this study was to evaluate the approach of using diclofenac acid (DA) prodrugs for enhancing transdermal delivery. Methanol diclofenac ester (MD), ethylene glycol diclofenac ester (ED), glycerol diclofenac ester (GD), and 1,3-propylene glycol diclofenac ester (PD) were synthesized and evaluated for their physicochemical properties such as solubilities, octanol/water partition coefficients, stratum corneum/water partition coefficients, hydrolysis rates, and bioconversion rates. ...

The effect of a structured neonatal resuscitation program on delivery room practices.

LENUS (Irish Health Repository)

Ryan, C A

2012-02-03

PURPOSE: This study evaluated the introduction of the Neonatal Resuscitation Program (NRP) of the American Academy of Pediatrics and the American Heart Association into the delivery room of an Irish maternity hospital. DESIGN: Prospective, controlled observational study of 51 deliveries before and 51 deliveries following the training of delivery room personnel in the NRP. SAMPLE: Participants were 33 nurse-midwives and 11 pediatric resident physicians. MAIN OUTCOME VARIABLE: Evaluation of postdelivery, newborn resuscitation practices. RESULTS: The introduction of the NRP was associated with significant improvements in delivery room preparation, in the evaluation and management of the newborn infant, and in thermal protection at birth. Although there was a trend to use more free-flow oxygen following the introduction of the NRP, this was not statistically significant. Bag and mask ventilation was also used more frequently following NRP training. However, there were no significant differences in the use of endotracheal intubation, chest compressions, and medications. Fifteen of the 51 infants became hypothermic prior to the introduction of the NRP; none of the infants developed hypothermia in the post-NRP part of the study.

Safety design integrated in the Building Delivery System

DEFF Research Database (Denmark)

Jørgensen, Kirsten

2012-01-01

phases of the building delivery system by using the principle of the lean construction modelling. The method for the research was to go through the lean construction building delivery system step by step and create a normative description of what to do, when to do and how to do to fully integration...... of safety in each process. The group of participants who created the description had a high experience in a combination of research, safety and health in general and especial in construction and knowledge of the lean construction processes both from the clients perspective as well as from the designers...... and the consultants. The result is a concept and guideline including control schemes for how to integrate safety design in the lean construction building delivery system including what to do and when. The concept has been tested in an educational context and found useful by the designers. The practical value...

Formulation and Evaluation of Two-Pulse Drug Delivery System of ...

African Journals Online (AJOL)

Purpose: To develop a pH-controlled two-pulse drug delivery system of amoxicillin in order to overcome the snag of biological ... Conclusion: The developed formulation demonstrates the feasibility of a two-phase release of amoxicillin separated by a ... comprised of a calorimeter (DSC 60), flow controller (FCL 60), thermal ...

Current Practices in the Delivery of Undergraduate Exercise Physiology Content

Science.gov (United States)

Fisher, Michele M.

2013-01-01

The purpose of this study was to identify current practices for the delivery of exercise physiology content at the undergraduate level. An anonymous 22-item survey was sent to instructors of exercise physiology to collect information concerning the structure of course offerings and instructional practices. One hundred ten instructors responded to…

Development of wood fuel delivery logistics; Puupolttoaineiden hankintalogistiikan kehittaeminen

Energy Technology Data Exchange (ETDEWEB)

Laitinen, H

1997-12-31

The main aim of the project is to model the energy wood business and total logistics in a certain large region. First, wood utilisation locations inside this area are examined; the most important ones are the wood processing factories, and the heating- and power plants. After that, wood potentials in the forests of the area are evaluated in sub-areas suitable in size and sufficiently detailed for further evaluations. For that purpose, the most valuable source data are forest management plans, up to ten years forward, on which basis the wood fuel potentials can be evaluated following sustainable development. In Finland there are extensive and detailed data bases storing forest information and it is possible to collect necessary data for a data base applicable to our calculations. In logistical sense it is important to know, by which delivery chains the economically best and desired results are achieved. The software prototype based on data base is modelled and developed at VTT Energy, for facilitating these planning activities. The starting point of the planning system in delivery logistics is the implementation of an easy tool for versatile planning so that with this tool model different delivery chains can be flexiblyed, create usage scenarios, make alternative examinations, and calculate impacts of different factors on energy wood amounts yielded and delivery costs. With planning system in delivery logistics we calculate production costs and amounts delivered to different utilisation locations. The system offers tools for definitions of utilisation locations, calculation parameters, and delivery chains

Development of wood fuel delivery logistics; Puupolttoaineiden hankintalogistiikan kehittaeminen

Energy Technology Data Exchange (ETDEWEB)

Laitinen, H.

1996-12-31

The main aim of the project is to model the energy wood business and total logistics in a certain large region. First, wood utilisation locations inside this area are examined; the most important ones are the wood processing factories, and the heating- and power plants. After that, wood potentials in the forests of the area are evaluated in sub-areas suitable in size and sufficiently detailed for further evaluations. For that purpose, the most valuable source data are forest management plans, up to ten years forward, on which basis the wood fuel potentials can be evaluated following sustainable development. In Finland there are extensive and detailed data bases storing forest information and it is possible to collect necessary data for a data base applicable to our calculations. In logistical sense it is important to know, by which delivery chains the economically best and desired results are achieved. The software prototype based on data base is modelled and developed at VTT Energy, for facilitating these planning activities. The starting point of the planning system in delivery logistics is the implementation of an easy tool for versatile planning so that with this tool model different delivery chains can be flexiblyed, create usage scenarios, make alternative examinations, and calculate impacts of different factors on energy wood amounts yielded and delivery costs. With planning system in delivery logistics we calculate production costs and amounts delivered to different utilisation locations. The system offers tools for definitions of utilisation locations, calculation parameters, and delivery chains

45 CFR 90.2 - What is the purpose of these regulations?

Science.gov (United States)

2010-10-01

... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General § 90.2 What is the purpose of these regulations? (a) The purpose of these regulations is to state general... 45 Public Welfare 1 2010-10-01 2010-10-01 false What is the purpose of these regulations? 90.2...

Academic general internal medicine: a mission for the future.

Science.gov (United States)

Armstrong, Katrina; Keating, Nancy L; Landry, Michael; Crotty, Bradley H; Phillips, Russell S; Selker, Harry P

2013-06-01

After five decades of growth that has included advances in medical education and health care delivery, value cohesion, and integration of diversity, we propose an overarching mission for academic general internal medicine to lead excellence, change, and innovation in clinical care, education, and research. General internal medicine aims to achieve health care delivery that is comprehensive, technologically advanced and individualized; instills trust within a culture of respect; is efficient in the use of time, people, and resources; is organized and financed to achieve optimal health outcomes; maximizes equity; and continually learns and adapts. This mission of health care transformation has implications for the clinical, educational, and research activities of divisions of general internal medicine over the next several decades.

DIDACTIC PRINCIPLES AND PSYCHOLOGICAL CHARACTERISTICS IN DEFINITION OF QUALITY OF SOFTWARE TOOLS FOR EDUCATIONAL PURPOSE IN THE GENERAL EDUCATIONAL ENVIRONMENT OF UKRAINE

Directory of Open Access Journals (Sweden)

Maryna V. Pirko

2011-02-01

Full Text Available The fundamental feature of economy of postindustrial society is the knowledge that represents the basic source of competitive advantage. In the article the circle of didactic, psychological indicators in researches of problems of achievement of a high degree of quality of education and educational services is considered and described. The attention is paid to pedagogical requirements of the given period which are a standard substantiation in orientations for quality estimation of software tools for educational purpose of the general educational environment in Ukraine. The scheme of internal model of maintenance of quality of software tools for educational purpose is considered, the aspects integrated by internal model of quality of software for educational purpose are listed. The article describes the directions of researches in the conditions of formation of the global international educational environment and uniform information space of  education system taking into account the growth of availability of educational services. It is specified the main principles in the organization of pedagogical software tools.

34 CFR 668.161 - Scope and purpose (cash management rules).

Science.gov (United States)

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Scope and purpose (cash management rules). 668.161... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT ASSISTANCE GENERAL PROVISIONS Cash Management § 668.161 Scope and purpose (cash management rules). (a) General. (1) This subpart establishes the rules and...

Emergent management of postpartum hemorrhage for the general and acute care surgeon

Directory of Open Access Journals (Sweden)

Blankenship Charles L

2009-11-01

Full Text Available Abstract Background Postpartum hemorrhage is one of the rare occasions when a general or acute care surgeon may be emergently called to labor and delivery, a situation in which time is limited and the stakes high. Unfortunately, there is generally a paucity of exposure and information available to surgeons regarding this topic: obstetric training is rarely found in contemporary surgical residency curricula and is omitted nearly completely from general and acute care surgery literature and continuing medical education. Methods The purpose of this manuscript is to serve as a topic specific review for surgeons and to present a surgeon oriented management algorithm. Medline and Ovid databases were utilized in a comprehensive literature review regarding the management of postpartum hemorrhage and a management algorithm for surgeons developed based upon a collaborative panel of general, acute care, trauma and obstetrical surgeons' review of the literature and expert opinion. Results A stepwise approach for surgeons of the medical and surgical interventions utilized to manage and treat postpartum hemorrhage is presented and organized into a basic algorithm. Conclusion The manuscript should promote and facilitate a more educated, systematic and effective surgeon response and participation in the management of postpartum hemorrhage.

An emerging integration between ionic liquids and nanotechnology: general uses and future prospects in drug delivery.

Science.gov (United States)

de Almeida, Tânia Santos; Júlio, Ana; Mota, Joana Portugal; Rijo, Patrícia; Reis, Catarina Pinto

2017-06-01

There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release. Consequently, structures containing ILs and nanoparticles (NPs) have been developed to attain synergistic effects. This overview on the properties of ILs, NPs and of their combined structures, reveals the recent advances in these areas through a review of pertinent literature. The IL-NP structures present enhanced properties and the subsequent performance upgrade proves to be useful in drug delivery, although much is yet to be done.

Printing technologies in fabrication of drug delivery systems.

Science.gov (United States)

Kolakovic, Ruzica; Viitala, Tapani; Ihalainen, Petri; Genina, Natalja; Peltonen, Jouko; Sandler, Niklas

2013-12-01

There has been increased activity in the field recently regarding the development and research on various printing techniques in fabrication of dosage forms and drug delivery systems. These technologies may offer benefits and flexibility in manufacturing, potentially paving the way for personalized dosing and tailor-made dosage forms. In this review, the most recent observations and advancements in fabrication of drug delivery systems by utilizing printing technologies are summarized. A general overview of 2D printing techniques is presented including a review of the most recent literature where printing techniques are used in fabrication of drug delivery systems. The future perspectives and possible impacts on formulation strategies, flexible dosing and personalized medication of using printing techniques for fabrication of drug delivery systems are discussed. It is evident that there is an urgent need to meet the challenges of rapidly growing trend of personalization of medicines through development of flexible drug-manufacturing approaches. In this context, various printing technologies, such as inkjet and flexography, can play an important role. Challenges on different levels exist and include: i) technological development of printers and production lines; ii) printable formulations and carrier substrates; iii) quality control and characterization; and iv) regulatory perspectives.

10 CFR 60.1 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Purpose and scope. 60.1 Section 60.1 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.1 Purpose and scope. This part prescribes rules governing the licensing (including issuance...

28 CFR 513.10 - Purpose and scope.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Purpose and scope. 513.10 Section 513.10 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.10 Purpose and scope. This...

Design and Simulation of a High Performance Emergency Data Delivery Protocol

DEFF Research Database (Denmark)

Swartz, Kevin; Wang, Di

2007-01-01

The purpose of this project was to design a high performance data delivery protocol, capable of delivering data as quickly as possible to a base station or target node. This protocol was designed particularly for wireless network topologies, but could also be applied towards a wired system....... An emergency is defined as any event with high priority that needs to be handled immediately. It is assumed that this emergency event is important enough that energy efficiency is not a factor in our protocol. The desired effect is for fast as possible delivery to the base station for rapid event handling....

Duplication of complete dentures using general-purpose handheld optical scanner and 3-dimensional printer: Introduction and clinical considerations.

Science.gov (United States)

Kurahashi, Kosuke; Matsuda, Takashi; Goto, Takaharu; Ishida, Yuichi; Ito, Teruaki; Ichikawa, Tetsuo

2017-01-01

To introduce a new clinical procedure for fabricating duplicates of complete dentures by bite pressure impression using digital technology, and to discuss its clinical significance. The denture is placed on a rotary table and the 3-dimensional form of the denture is digitized using a general-purpose handheld optical scanner. The duplicate denture is made of polylactic acid by a 3-dimensional printer using the 3-dimensional data. This procedure has the advantages of wasting less material, employing less human power, decreasing treatment time at the chair side, lowering the rates of contamination, and being readily fabricated at the time of the treatment visit. Copyright © 2016 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

42 CFR 4.3 - Purpose of the Library.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Purpose of the Library. 4.3 Section 4.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS NATIONAL LIBRARY OF MEDICINE § 4.3 Purpose of the Library. The purpose of the Library is to assist the advancement of...

Sociocultural determinants of home delivery in Ethiopia: a qualitative study.

Science.gov (United States)

Kaba, Mirgissa; Bulto, Tesfaye; Tafesse, Zergu; Lingerh, Wassie; Ali, Ismael

2016-01-01

Maternal health remains a major public health problem in Ethiopia. Despite the government's measures to ensure institutional delivery assisted by skilled attendants, home delivery remains high, estimated at over 80% of all pregnant women. The study aims to identify determinants that sustain home delivery in Ethiopia. A total of 48 women who delivered their most recent child at home, 56 women who delivered their most recent child in a health facility, 55 husbands of women who delivered within 1 year preceding the study, and 23 opinion leaders in selected districts of Amhara, Oromia, Southern Nations, Nationalities, and Peoples' Region, and Tigray regions were involved in the study. Key informant interview, in-depth interviews, and focus group discussions were conducted to collect data using checklists developed for this purpose. Data reduction and analysis were facilitated by Maxqda qualitative data analysis software version 11. Findings show that pregnancy and delivery is a normal and natural life event. Research participants unanimously argue that such a life event should not be linked with health problems. Home is considered a natural space for delivery and most women aspire to deliver at home where rituals during labor and after delivery are considered enjoyable. Even those who delivered in health facilities appreciate events in connection to home delivery. Efforts are underway to create home-like environments in health facilities, but health facilities are not yet recognized as a natural place of delivery. The positive tendency to deliver at home is further facilitated by poor service delivery at the facility level. Perceived poor competence of providers and limited availability of supplies and equipment were found to maintain the preference to deliver at home. The government's endeavor to improve maternal health has generated positive results with more women now attending antenatal care. Yet over 80% of women deliver at home and this was found to be the

29 CFR 570.114 - General.

Science.gov (United States)

2010-07-01

... to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION General Statements of Interpretation of the Child Labor... employment of oppressive child labor. Instead, it prohibits the shipment or delivery for shipment in...

Potentiality of the Usage of Compressed Natural Gas for Competitiveness in Service Delivery Industries

Directory of Open Access Journals (Sweden)

Gazi Mohammad Hasan Jamil

2014-08-01

Full Text Available Abstract. With the rising costs of gasoline, many vehicle owners are looking for alternatives of it. Compressed natural gas (CNG has been tested for this very purpose in some countries and found as a better alternative so far. CNG comes from country’s natural resources and it is clean and less costly to use. This paper is mainly an analysis of the potential benefits of using natural gas as a transportation fuel by the service delivery industries. It will examine CNG’s potential contribution in reducing delivery and vehicle maintenance cost, saving money in the long run projects, improving fuel efficiency, enhancing physical safety and assuring environment friendly emissions of carbon monoxide or reactive gases for the service delivery industries.Keywords: Compressed natural gas (CNG, Service Delivery, Fossil fuel, Global warming, Competitiveness

In Vitro/In Vivo Evaluation of Dexamethasone--PAMAM Dendrimer Complexes for Retinal Drug Delivery.

Science.gov (United States)

Yavuz, Burçin; Pehlivan, Sibel Bozdağ; Vural, İmran; Ünlü, Nurşen

2015-11-01

Current treatment options for diabetic retinopathy (DR) have side effects because of invasive application and topical application does not generally result in therapeutic levels in the target tissue. Therefore, improving the drug delivery to retina, following topical administration, might be a solution to DR treatment problems. The purpose of this study was to investigate the complexation effects of poly(amidoamine) (PAMAM) dendrimers on ocular absorption of dexamethasone (DEX). Using different PAMAM generations, complex formulations were prepared and characterized. Formulations were evaluated in terms of cytotoxicity and cell permeability, as well as ex vivo transport across ocular tissues. The ocular pharmacokinetic properties of DEX formulations were studied in Sprague-Dawley rats following topical and subconjunctival applications, to evaluate the effect of PAMAM on retinal delivery of DEX. Methyl-thiazol-tetrazolium (MTT) assay indicated that all groups resulted in cell viability comparable to DEX solution (87.5%), with the cell viability being the lowest for G3 complex at 73.5%. Transport study results showed that dendrimer complexation increases DEX transport across both cornea and sclera tissues. The results of in vivo studies were also indicated that especially anionic DEX-PAMAM complex formulations have reached higher DEX concentrations in ocular tissues compared with plain DEX suspension. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

Nanotechnology and Drug Delivery Part 1: Background and ...

African Journals Online (AJOL)

Nanotechnology in general and as it relates to drug delivery in humans has been reviewed in a two-part article, the first part of which is this paper. In this paper, nanotechnology in nature, history of nanotechnology and methods of synthesis are discussed, while also outlining its applications, benefits and risks.

How to move towards community based service delivery?

NARCIS (Netherlands)

Meuwissen, L.; Voorham, T.; Bakker, D. de

2007-01-01

Aim: Community based primary health care offers in potential the opportunity to tailor health service delivery to the needs and demands of the local population. Up to now, there is no clear cut method to do this. In a pilot benchmark for general practices, data were collected on demand and

10 CFR 63.1 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Purpose and scope. 63.1 Section 63.1 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.1 Purpose and scope. This part prescribes rules governing the...

40 CFR 8.1 - Purpose.

Science.gov (United States)

2010-07-01

... provides for: (1) The environmental impact assessment of nongovernmental activities, including tourism, for... Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.1 Purpose. (a) This part is issued pursuant to the Antarctic Science, Tourism...

5 CFR 330.701 - Purpose.

Science.gov (United States)

2010-01-01

... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Interagency Career Transition Assistance Plan for Displaced Employees § 330.701 Purpose... interagency career transition assistance program for Federal employees during a period of severe Federal...

Albumin-mediated delivery of siRNA

DEFF Research Database (Denmark)

Bienk, Konrad

2015-01-01

. The human body, however, possesses several natural transport mechanisms for active transport of molecules. Amongst these is albumin, which is the most abundant plasma protein and has a circulatory half-life of ~21 days, partially due to engagement and recycling by the neonatal Fc receptor (FcRn). Albumin...... vehicle. This proof of concept silencing showed that siRNA can be used for therapeutic purposes without the use of non-biocompatible polymer or lipid materials. This work, therefore, provides a novel technology platform for the safe delivery of siRNA therapeutics....

Mononuclear phagocytes as a target, not a barrier, for drug delivery.

Science.gov (United States)

Yong, Seok-Beom; Song, Yoonsung; Kim, Hyung Jin; Ain, Qurrat Ul; Kim, Yong-Hee

2017-08-10

Mononuclear phagocytes have been generally recognized as a barrier to drug delivery. Recently, a new understanding of mononuclear phagocytes (MPS) ontogeny has surfaced and their functions in disease have been unveiled, demonstrating the need for re-evaluation of perspectives on mononuclear phagocytes in drug delivery. In this review, we described mononuclear phagocyte biology and focus on their accumulation mechanisms in disease sites with explanations of monocyte heterogeneity. In the 'MPS as a barrier' section, we summarized recent studies on mechanisms to avoid phagocytosis based on two different biological principles: protein adsorption and self-recognition. In the 'MPS as a target' section, more detailed descriptions were given on mononuclear phagocyte-targeted drug delivery systems and their applications to various diseases. Collectively, we emphasize in this review that mononuclear phagocytes are potent targets for future drug delivery systems. Mononuclear phagocyte-targeted delivery systems should be created with an understanding of mononuclear phagocyte ontogeny and pathology. Each specific subset of phagocytes should be targeted differently by location and function for improved disease-drug delivery while avoiding RES clearance such as Kupffer cells and splenic macrophages. Copyright © 2017 Elsevier B.V. All rights reserved.

A Comparative Analysis of the Environmental Benefits of Drone-Based Delivery Services in Urban and Rural Areas

Directory of Open Access Journals (Sweden)

Jiyoon Park

2018-03-01

Full Text Available Unmanned aerial vehicles (UAV, drones used as delivery vehicles have received increasing attention due to their mobility and accessibility to remote areas. The purpose of this study is to evaluate the environmental impacts of drone versus motorcycle delivery and to compare the expected environmental improvements due to drone delivery in urban and rural areas. In addition, the potential environmental contributions of electric motorcycles were assessed to determine the effects of introducing this new type of vehicle. Changes in the national electricity generation plan were also examined. The results showed that global warming potential (GWP per 1 km delivery by drone was one-sixth that of motorcycle delivery, and the particulates produced by drone delivery were half that of motorcycle delivery. The actual environmental impact reduction in consideration of the delivery distance was 13 times higher in a rural area than in an urban area. Increasing the use of environmentally friendly electricity systems, such as solar and wind power, would further enhance the environmental effects of a drone delivery system.

Intraoperative adverse events associated with extremely preterm cesarean deliveries.

Science.gov (United States)

Bertholdt, Charline; Menard, Sophie; Delorme, Pierre; Lamau, Marie-Charlotte; Goffinet, François; Le Ray, Camille

2018-05-01

At the same time as survival is increasing among premature babies born before 26 weeks of gestation, the rates of cesarean deliveries before 26 weeks is also rising. Our purpose was to compare the frequency of intraoperative adverse events during cesarean deliveries in two gestational age groups: 24-25 weeks and 26-27 weeks. This single-center retrospective cohort study included all women with cesarean deliveries performed before 28 +0 weeks from 2007 through 2015. It compared the frequency of intraoperative adverse events between two groups: those at 24-25 weeks of gestation and at 26-27 weeks. Intraoperative adverse events were a classical incision, transplacental incision, difficulty in fetal extraction (explicitly mentioned in the surgical report), postpartum hemorrhage (≥500 mL of blood loss), and injury to internal organs. A composite outcome including at least one of these events enabled us to analyze the risk factors for intraoperative adverse events with univariate and multivariable analysis. Stratified analyses by the indication for the cesarean were performed. We compared 74 cesarean deliveries at 24-25 weeks of gestation and 214 at 26-27 weeks. Intraoperative adverse events occurred at higher rates in the 24-25-week group (63.5 vs. 30.8%, p cesarean. These results should help obstetricians and women making decisions about cesarean deliveries at these extremely low gestational ages. © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system

Energy Technology Data Exchange (ETDEWEB)

Locatelli, Erica; Comes Franchini, Mauro, E-mail: mauro.comesfranchini@unibo.it [University of Bologna, Dipartimento di Chimica Industriale Toso Montanari (Italy)

2012-12-15

During the past decades many synthetic polymers have been studied for nanomedicine applications and in particular as drug delivery systems. For this purpose, polymers must be non-toxic, biodegradable, and biocompatible. Polylactic-co-glycolic acid (PLGA) is one of the most studied polymers due to its complete biodegradability and ability to self-assemble into nanometric micelles that are able to entrap small molecules like drugs and to release them into body in a time-dependent manner. Despite fine qualities, using PLGA polymeric nanoparticles for in vivo applications still remains an open challenge due to many factors such as poor stability in water, big diameter (150-200 nm), and the removal of these nanocarriers from the blood stream by the liver and spleen thus reducing the concentration of drugs drastically in tumor tissue. Polyethylene glycol (PEG) is the most used polymers for drug delivery applications and the first PEGylated product is already on the market for over 20 years. This is due to its stealth behavior that inhibits the fast recognition by the immune system (opsonization) and generally leads to a reduced blood clearance of nanocarriers increasing blood circulation time. Furthermore, PEG is hydrophilic and able to stabilize nanoparticles by steric and not ionic effects especially in water. PLGA-PEG block copolymer is an emergent system because it can be easily synthesized and it possesses all good qualities of PLGA and also PEG capability so in the last decade it arose as one of the most promising systems for nanoparticles formation, drug loading, and in vivo drug delivery applications. This review will discuss briefly on PLGA-b-PEG synthesis and physicochemical properties, together with its improved qualities with respect to the single PLGA and PEG polymers. Moreover, we will focus on but in particular will treat nanoparticles formation and uses as new drug delivery system for nanomedical applications.

Architecture of a general purpose embedded Slow-Control Adapter ASIC for future high-energy physics experiments

International Nuclear Information System (INIS)

Gabrielli, Alessandro; Loddo, Flavio; Ranieri, Antonio; De Robertis, Giuseppe

2008-01-01

This work is aimed at defining the architecture of a new digital ASIC, namely Slow-Control Adapter (SCA), which will be designed in a commercial 130-nm CMOS technology. This chip will be embedded within a high-speed data acquisition optical link (GBT) to control and monitor the front-end electronics in future high-energy physics experiments. The GBT link provides a transparent transport layer between the SCA and control electronics in the counting room. The proposed SCA supports a variety of common bus protocols to interface with end-user general-purpose electronics. Between the GBT and the SCA a standard 100 Mb/s IEEE-802.3 compatible protocol will be implemented. This standard protocol allows off-line tests of the prototypes using commercial components that support the same standard. The project is justified because embedded applications in modern large HEP experiments require particular care to assure the lowest possible power consumption, still offering the highest reliability demanded by very large particle detectors.

Architecture of a general purpose embedded Slow-Control Adapter ASIC for future high-energy physics experiments

Science.gov (United States)

Gabrielli, Alessandro; Loddo, Flavio; Ranieri, Antonio; De Robertis, Giuseppe

2008-10-01

This work is aimed at defining the architecture of a new digital ASIC, namely Slow-Control Adapter (SCA), which will be designed in a commercial 130-nm CMOS technology. This chip will be embedded within a high-speed data acquisition optical link (GBT) to control and monitor the front-end electronics in future high-energy physics experiments. The GBT link provides a transparent transport layer between the SCA and control electronics in the counting room. The proposed SCA supports a variety of common bus protocols to interface with end-user general-purpose electronics. Between the GBT and the SCA a standard 100 Mb/s IEEE-802.3 compatible protocol will be implemented. This standard protocol allows off-line tests of the prototypes using commercial components that support the same standard. The project is justified because embedded applications in modern large HEP experiments require particular care to assure the lowest possible power consumption, still offering the highest reliability demanded by very large particle detectors.

Modified montmorillonite as vector for gene delivery.

Science.gov (United States)

Lin, Feng-Huei; Chen, Chia-Hao; Cheng, Winston T K; Kuo, Tzang-Fu

2006-06-01

Currently, gene delivery systems can be divided into two parts: viral or non-viral vectors. In general, viral vectors have a higher efficiency on gene delivery. However, they may sometimes provoke mutagenesis and carcinogenesis once re-activating in human body. Lots of non-viral vectors have been developed that tried to solve the problems happened on viral vectors. Unfortunately, most of non-viral vectors showed relatively lower transfection rate. The aim of this study is to develop a non-viral vector for gene delivery system. Montmorillonite (MMT) is one of clay minerals that consist of hydrated aluminum with Si-O tetrahedrons on the bottom of the layer and Al-O(OH)2 octahedrons on the top. The inter-layer space is about 12 A. The room is not enough to accommodate DNA for gene delivery. In the study, the cationic hexadecyltrimethylammonium (HDTMA) will be intercalated into the interlayer of MMT as a layer expander to expand the layer space for DNA accommodation. The optimal condition for the preparation of DNA-HDTMA-MMT is as follows: 1 mg of 1.5CEC HDTMA-MMT was prepared under pH value of 10.7 and with soaking time for 2 h. The DNA molecules can be protected from nuclease degradation, which can be proven by the electrophoresis analysis. DNA was successfully transfected into the nucleus of human dermal fibroblast and expressed enhanced green fluorescent protein (EGFP) gene with green fluorescence emission. The HDTMA-MMT has a great potential as a vector for gene delivery in the future.