WorldWideScience

Sample records for general purpose delivery

  1. General purpose MDE tools

    Directory of Open Access Journals (Sweden)

    Juan Manuel Cueva Lovelle

    2008-12-01

    Full Text Available MDE paradigm promises to release developers from writing code. The basis of this paradigm consists in working at such a level of abstraction that will make it easyer for analysts to detail the project to be undertaken. Using the model described by analysts, software tools will do the rest of the task, generating software that will comply with customer's defined requirements. The purpose of this study is to compare general purpose tools available right now that enable to put in practice the principles of this paradigm and aimed at generating a wide variety of applications composed by interactive multimedia and artificial intelligence components.

  2. General purpose operator interface

    Energy Technology Data Exchange (ETDEWEB)

    Bennion, S. I.

    1979-07-01

    The Hanford Engineering Development Laboratory in Richland, Washington is developing a general-purpose operator interface for controlling set-point driven processes. The interface concept is being developed around graphics display devices with touch-sensitive screens for direct interaction with the displays. Additional devices such as trackballs and keyboards are incorporated for the operator's convenience, but are not necessary for operation. The hardware and software are modular; only those capabilities needed for a particular application need to be used. The software is written in FORTRAN IV with minimal use of operating system calls to increase portability. Several ASCII files generated by the user define displays and correlate the display variables with the process parameters. It is also necessary for the user to build an interface routine which translates the internal graphics commands into device-specific commands. The interface is suited for both continuous flow processes and unit operations. An especially useful feature for controlling unit operations is the ability to generate and execute complex command sequences from ASCII files. This feature relieves operators of many repetitive tasks. 2 figures.

  3. Multi-point injection: A general purpose delivery system for treatment and containment of hazardous and radiological waste

    Energy Technology Data Exchange (ETDEWEB)

    Kauschinger, J.L. [Ground Environmental Services, Alpharetta, GA (United States); Kubarewicz, J. [Jacobs Engineering, Oak Ridge, TN (United States); Van Hoesen, S.D. [Lockheed Martin Energy Systems, Oak Ridge, TN (United States)

    1997-12-31

    The multi-point injection (MPI) technology is a proprietary jetting process for the in situ delivery of various agents to treat radiological and/or chemical wastes. A wide variety of waste forms can be treated, varying from heterogeneous solid waste dumped into shallow burial trenches, bottom sludge (heel material) inside of underground tanks, and contaminated soils with widely varying soil composition (gravel, silts/clays, soft rock). The robustness of the MPI system is linked to the use of high speed mono-directional jets to deliver various types of agents for a variety of applications, such as: pretreatment of waste prior to insitu vitrification, solidification of waste for creating low conductivity monoliths, oxidants for insitu destruction of organic waste, and grouts for creating barriers (vertical, inclined, and bottom seals). The only strict limitation placed upon the MPI process is that the material can be pumped under high pressure. This paper describes the procedures to inject ordinary grout to form solidified monoliths of solid wastes.

  4. General Purpose (office) Network reorganisation

    CERN Multimedia

    IT Department

    2016-01-01

    On Saturday 27 August, the IT Department’s Communication Systems group will perform a major reorganisation of CERN’s General Purpose Network.   This reorganisation will cause network interruptions on Saturday 27 August (and possibly Sunday 28 August) and will be followed by a change to the IP addresses of connected systems that will come into effect on Monday 3 October. For further details and information about the actions you may need to take, please see: https://information-technology.web.cern.ch/news/general-purpose-office-network-reorganisation.

  5. General purpose steam table library :

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, John H.; Belcourt, Kenneth Noel; Nourgaliev, Robert

    2013-08-01

    Completion of the CASL L3 milestone THM.CFD.P7.04 provides a general purpose tabular interpolation library for material properties to support, in particular, standardized models for steam properties. The software consists of three parts, implementations of analytic steam models, a code to generate tables from those models, and an interpolation package to interface the tables to CFD codes such as Hydra-TH. Verification of the standard model is maintained through the entire train of routines. The performance of interpolation package exceeds that of freely available analytic implementation of the steam properties by over an order of magnitude.

  6. 12 CFR 1703.31 - General purposes.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false General purposes. 1703.31 Section 1703.31 Banks... DEVELOPMENT OFHEO ORGANIZATION AND FUNCTIONS RELEASE OF INFORMATION Testimony and Production of Documents in... time of employees for their official duties, maintain the impartial position of OFHEO in litigation...

  7. General purpose optimization software for engineering design

    Science.gov (United States)

    Vanderplaats, G. N.

    1990-01-01

    The author has developed several general purpose optimization programs over the past twenty years. The earlier programs were developed as research codes and served that purpose reasonably well. However, in taking the formal step from research to industrial application programs, several important lessons have been learned. Among these are the importance of clear documentation, immediate user support, and consistent maintenance. Most important has been the issue of providing software that gives a good, or at least acceptable, design at minimum computational cost. Here, the basic issues developing optimization software for industrial applications are outlined and issues of convergence rate, reliability, and relative minima are discussed. Considerable feedback has been received from users, and new software is being developed to respond to identified needs. The basic capabilities of this software are outlined. A major motivation for the development of commercial grade software is ease of use and flexibility, and these issues are discussed with reference to general multidisciplinary applications. It is concluded that design productivity can be significantly enhanced by the more widespread use of optimization as an everyday design tool.

  8. General purpose fast decoupled power flow

    Energy Technology Data Exchange (ETDEWEB)

    Nanda, J.; Bijwe, P.R.; Henry, J.; Bapi Raju, V. (Indian Inst. of Tech., New Delhi (IN). Dept. of Electrical Engineering)

    1992-03-01

    A general purpose fast decoupled power flow model (GFDPF) is presented that exhibits more or less best convergence properties for both well-behaved and ill-conditioned systems. In the proposed model, all network shunts such as line charging, external shunts at buses, shunts formed due to {pi} representation of off-nominal in-phase transformers etc. are treated as constant impedance loads. The effect of line resistances is considered while forming the (B') matrix and are ignored in forming the (B'') matrix. This model is tested on several systems for both well-behaved and ill-conditioned situations. A simple, efficient compensation technique is proposed to deal with Q-limit enforcements associated with bus-type switchings at voltage-controlled buses. The results demonstrate that the proposed GFDPF model exhibits more or less stable convergence behaviour for both well-behaved and ill-conditioned situations. (author).

  9. SRAC95; general purpose neutronics code system

    Energy Technology Data Exchange (ETDEWEB)

    Okumura, Keisuke; Tsuchihashi, Keichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Kaneko, Kunio

    1996-03-01

    SRAC is a general purpose neutronics code system applicable to core analyses of various types of reactors. Since the publication of JAERI-1302 for the revised SRAC in 1986, a number of additions and modifications have been made for nuclear data libraries and programs. Thus, the new version SRAC95 has been completed. The system consists of six kinds of nuclear data libraries(ENDF/B-IV, -V, -VI, JENDL-2, -3.1, -3.2), five modular codes integrated into SRAC95; collision probability calculation module (PIJ) for 16 types of lattice geometries, Sn transport calculation modules(ANISN, TWOTRAN), diffusion calculation modules(TUD, CITATION) and two optional codes for fuel assembly and core burn-up calculations(newly developed ASMBURN, revised COREBN). In this version, many new functions and data are implemented to support nuclear design studies of advanced reactors, especially for burn-up calculations. SRAC95 is available not only on conventional IBM-compatible computers but also on scalar or vector computers with the UNIX operating system. This report is the SRAC95 users manual which contains general description, contents of revisions, input data requirements, detail information on usage, sample input data and list of available libraries. (author).

  10. General purpose modeling languages for configuration

    DEFF Research Database (Denmark)

    Queva, Matthieu Stéphane Benoit

    In the later years, there has been an important need for companies to reduce their costs while proposing highly customized products. Indeed, today's customers demand products with lower prices, higher quality and faster delivery, but they also want products customized to match their unique needs....

  11. Can Universities Profit from General Purpose Inventions?

    DEFF Research Database (Denmark)

    Barirani, Ahmad; Beaudry, Catherine; Agard, Bruno

    2017-01-01

    The lack of control over downstream assets can hinder universities’ ability to extract rents from their inventive activities. We explore this possibility by assessing the relationship between invention generality and renewal decisions for a sample of Canadian nanotechnology patents. Our results s...

  12. 47 CFR 32.6124 - General purpose computers expense.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false General purpose computers expense. 32.6124... General purpose computers expense. This account shall include the costs of personnel whose principal job is the physical operation of general purpose computers and the maintenance of operating systems. This...

  13. General English Ability, Specific Purpose English Ability, and Computer Skills.

    Science.gov (United States)

    Prapphal, Kanchana

    2003-01-01

    Aims to answer the following research questions: (1) Are general English ability and specific purpose English ability related to computer skills? and (2) Is general English ability transferable to specific purpose English ability? Subjects were third year science students enrolled in an English for academic purposes course. (Author/VWL)

  14. 47 CFR 32.2124 - General purpose computers.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false General purpose computers. 32.2124 Section 32... General purpose computers. (a) This account shall include the original cost of computers and peripheral... cost of computers and their associated peripheral devices associated with switching, network signaling...

  15. 78 FR 7718 - Review of the General Purpose Costing System

    Science.gov (United States)

    2013-02-04

    ... Surface Transportation Board 49 CFR Parts 1247 and 1248 Review of the General Purpose Costing System... general purpose costing system, the Uniform Railroad Costing System (URCS). Specifically, the Board is..., 2013. ADDRESSES: Comments may be submitted either via the Board's e-filing format or in the traditional...

  16. Ultrasonic Drug Delivery – A General Review

    Science.gov (United States)

    Pitt, William G.; Husseini, Ghaleb A.; Staples, Bryant J.

    2006-01-01

    Ultrasound (US) has an ever-increasing role in the delivery of therapeutic agents including genetic material, proteins, and chemotherapeutic agents. Cavitating gas bodies such as microbubbles are the mediators through which the energy of relatively non-interactive pressure waves is concentrated to produce forces that permeabilize cell membranes and disrupt the vesicles that carry drugs. Thus the presence of microbubbles enormously enhances delivery of genetic material, proteins and smaller chemical agents. Delivery of genetic material is greatly enhanced by ultrasound in the presence of microbubbles. Attaching the DNA directly to the microbubbles or to gas-containing liposomes enhances gene uptake even further. US-enhanced gene delivery has been studied in various tissues including cardiac, vascular, skeletal muscle, tumor and even fetal tissue. US-enhanced delivery of proteins has found most application in transdermal delivery of insulin. Cavitation events reversibly disrupt the structure of the stratus corneum to allow transport of these large molecules. Other hormones and small proteins could also be delivered transdermally. Small chemotherapeutic molecules are delivered in research settings from micelles and liposomes exposed to ultrasound. Cavitation appears to play two roles: it disrupts the structure of the carrier vesicle and releases the drug; it also makes the cell membranes and capillaries more permeable to drugs. There remains a need to better understand the physics of cavitation of microbubbles and the impact that such cavitation has upon cells and drug-carrying vesicles. PMID:16296719

  17. Ultrasonic drug delivery--a general review.

    Science.gov (United States)

    Pitt, William G; Husseini, Ghaleb A; Staples, Bryant J

    2004-11-01

    Ultrasound has an ever-increasing role in the delivery of therapeutic agents, including genetic material, protein and chemotherapeutic agents. Cavitating gas bodies, such as microbubbles, are the mediators through which the energy of relatively non-interactive pressure waves is concentrated to produce forces that permeabilise cell membranes and disrupt the vesicles that carry drugs. Thus, the presence of microbubbles enormously enhances ultrasonic delivery of genetic material, proteins and smaller chemical agents. Numerous reports show that the most efficient delivery of genetic material occurs in the presence of cavitating microbubbles. Attaching the DNA directly to the microbubbles, or to gas-containing liposomes, enhances gene uptake even further. Ultrasonic-enhanced gene delivery has been studied in various tissues, including cardiac, vascular, skeletal muscle, tumour and even fetal tissue. Ultrasonic-assisted delivery of proteins has found most application in transdermal transport of insulin. Cavitation events reversibly disrupt the structure of the stratus corneum to allow transport of these large molecules. Other hormones and small proteins could also be delivered transdermally. Small chemotherapeutic molecules are delivered in research settings from micelles and liposomes exposed to ultrasound. Cavitation appears to play two roles: it disrupts the structure of the carrier vesicle and releases the drug; and makes cell membranes and capillaries more permeable to drugs. There remains a need to better understand the physics of cavitation of microbubbles and the impact that such cavitation has on cells and drug-carrying vesicles.

  18. 42 CFR 456.141 - Purpose and general description.

    Science.gov (United States)

    2010-10-01

    ...: Medical Care Evaluation Studies § 456.141 Purpose and general description. (a) The purpose of medical care evaluation studies is to promote the most effective and efficient use of available health facilities and... care evaluation studies— (1) Emphasize identification and analysis of patterns of patient care; and...

  19. 42 CFR 456.241 - Purpose and general description.

    Science.gov (United States)

    2010-10-01

    ... Ur Plan: Medical Care Evaluation Studies § 456.241 Purpose and general description. (a) The purpose of medical care evaluation studies is to promote the most effective and efficient use of available... health care. (b) Medical care evaluation studies— (1) Emphasize identification and analysis of...

  20. 7 CFR 249.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) General § 249.1 General... carry out the Senior Farmers' Market Nutrition Program (SFMNP). The purposes of the SFMNP are to:...

  1. 7 CFR 226.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM General § 226.1 General purpose and... Child and Adult Care Food Program. Section 17 of the National School Lunch Act, as amended,...

  2. Airway management for cesarean delivery performed under general anesthesia.

    Science.gov (United States)

    Rajagopalan, S; Suresh, M; Clark, S L; Serratos, B; Chandrasekhar, S

    2017-02-01

    With the increasing popularity of neuraxial anesthesia, there has been a decline in the use of general anesthesia for cesarean delivery. We sought to examine the incidence, outcome and characteristics associated with a failed airway in patients undergoing cesarean delivery under general anesthesia. A retrospective review of airway management in women undergoing cesarean delivery under general anesthesia over an eight-year period from 2006-2013 at an academic medical center was conducted. During the study period, 10 077 cesarean deliveries were performed. Neuraxial anesthesia was used in 9382 (93%) women while general anesthesia was used in 695 (7%). Emergent cesarean delivery was the most common indication for general anesthesia. Failed intubation was encountered in only three (0.4%) women, who were successfully managed with a laryngeal mask airway. The overall incidence of failed intubation was 1 in 232 (95% CI 1:83 to 1:666) and general anesthesia was continued in all cases. There were no adverse maternal or fetal outcomes directly related to failed intubation. Advances in adjunct airway equipment, availability of an experienced anesthesiologist and simulation-based teaching of failed airway management in obstetrics may have contributed to our improved maternal outcomes in patients undergoing cesarean delivery under general anesthesia. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. General-purpose isiZulu speech synthesiser

    CSIR Research Space (South Africa)

    Louw, A

    2005-07-01

    Full Text Available A general-purpose isiZulu text-to-speech (TTS) system was developed, based on the “Multisyn” unit-selection approach supported by the Festival TTS toolkit. The development involved a number of challenges related to the interface between speech...

  4. How General-Purpose can a GPU be?

    Directory of Open Access Journals (Sweden)

    Philip Machanick

    2015-12-01

    Full Text Available The use of graphics processing units (GPUs in general-purpose computation (GPGPU is a growing field. GPU instruction sets, while implementing a graphics pipeline, draw from a range of single instruction multiple datastream (SIMD architectures characteristic of the heyday of supercomputers. Yet only one of these SIMD instruction sets has been of application on a wide enough range of problems to survive the era when the full range of supercomputer design variants was being explored: vector instructions. This paper proposes a reconceptualization of the GPU as a multicore design with minimal exotic modes of parallelism so as to make GPGPU truly general.

  5. Using general-purpose compression algorithms for music analysis

    DEFF Research Database (Denmark)

    Louboutin, Corentin; Meredith, David

    2016-01-01

    General-purpose compression algorithms encode files as dictionaries of substrings with the positions of these strings’ occurrences. We hypothesized that such algorithms could be used for pattern discovery in music. We compared LZ77, LZ78, Burrows–Wheeler and COSIATEC on classifying folk song...... melodies. A novel method was used, combining multiple viewpoints, the k-nearest-neighbour algorithm and a novel distance metric, corpus compression distance. Using single viewpoints, COSIATEC outperformed the general-purpose compressors, with a classification success rate of 85% on this task. However...... in the input data, COSIATEC outperformed LZ77 with a mean F1 score of 0.123, compared with 0.053 for LZ77. However, when the music was processed a voice at a time, the F1 score for LZ77 more than doubled to 0.124. We also discovered a significant correlation between compression factor and F1 score for all...

  6. General-Purpose Serial Interface For Remote Control

    Science.gov (United States)

    Busquets, Anthony M.; Gupton, Lawrence E.

    1990-01-01

    Computer controls remote television camera. General-purpose controller developed to serve as interface between host computer and pan/tilt/zoom/focus functions on series of automated video cameras. Interface port based on 8251 programmable communications-interface circuit configured for tristated outputs, and connects controller system to any host computer with RS-232 input/output (I/O) port. Accepts byte-coded data from host, compares them with prestored codes in read-only memory (ROM), and closes or opens appropriate switches. Six output ports control opening and closing of as many as 48 switches. Operator controls remote television camera by speaking commands, in system including general-purpose controller.

  7. The ATLAS Trigger Algorithms for General Purpose Graphics Processor Units

    CERN Document Server

    Tavares Delgado, Ademar; The ATLAS collaboration

    2016-01-01

    The ATLAS Trigger Algorithms for General Purpose Graphics Processor Units Type: Talk Abstract: We present the ATLAS Trigger algorithms developed to exploit General­ Purpose Graphics Processor Units. ATLAS is a particle physics experiment located on the LHC collider at CERN. The ATLAS Trigger system has two levels, hardware-­based Level 1 and the High Level Trigger implemented in software running on a farm of commodity CPU. Performing the trigger event selection within the available farm resources presents a significant challenge that will increase future LHC upgrades. are being evaluated as a potential solution for trigger algorithms acceleration. Key factors determining the potential benefit of this new technology are the relative execution speedup, the number of GPUs required and the relative financial cost of the selected GPU. We have developed a trigger demonstrator which includes algorithms for reconstructing tracks in the Inner Detector and Muon Spectrometer and clusters of energy deposited in the Cal...

  8. General Purpose Multimedia Dataset - GarageBand 2008

    DEFF Research Database (Denmark)

    Meng, Anders

    This document describes a general purpose multimedia data-set to be used in cross-media machine learning problems. In more detail we describe the genre taxonomy applied at http://www.garageband.com, from where the data-set was collected, and how the taxonomy have been fused into a more human...... understandable taxonomy. Finally, a description of various features extracted from both the audio and text are presented....

  9. A general-purpose optimization program for engineering design

    Science.gov (United States)

    Vanderplaats, G. N.; Sugimoto, H.

    1986-01-01

    A new general-purpose optimization program for engineering design is described. ADS (Automated Design Synthesis) is a FORTRAN program for nonlinear constrained (or unconstrained) function minimization. The optimization process is segmented into three levels: Strategy, Optimizer, and One-dimensional search. At each level, several options are available so that a total of nearly 100 possible combinations can be created. An example of available combinations is the Augmented Lagrange Multiplier method, using the BFGS variable metric unconstrained minimization together with polynomial interpolation for the one-dimensional search.

  10. General-purpose fuzzy controller for dc-dc converters

    Energy Technology Data Exchange (ETDEWEB)

    Mattavelli, P.; Rossetto, L.; Spiazzi, G.; Tenti, P. [Univ. of Padova (Italy)

    1997-01-01

    In this paper, a general-purpose fuzzy controller for dc-dc converters is investigated. Based on a qualitative description of the system to be controlled, fuzzy controllers are capable of good performances, even for those systems where linear control techniques fail, e.g., when a mathematical description is not available or is in the presence of wide parameter variations. The presented approach is general and can be applied to any dc-dc converter topologies. Controller implementation is relatively simple and can guarantee a small-signal response as fast and stable as other standard regulators and an improved large-signal response. Simulation results of Buck-Boost and Sepic converters show control potentialities.

  11. GENETIC ALGORITHM ON GENERAL PURPOSE GRAPHICS PROCESSING UNIT: PARALLELISM REVIEW

    Directory of Open Access Journals (Sweden)

    A.J. Umbarkar

    2013-01-01

    Full Text Available Genetic Algorithm (GA is effective and robust method for solving many optimization problems. However, it may take more runs (iterations and time to get optimal solution. The execution time to find the optimal solution also depends upon the niching-technique applied to evolving population. This paper provides the information about how various authors, researchers, scientists have implemented GA on GPGPU (General purpose Graphics Processing Units with and without parallelism. Many problems have been solved on GPGPU using GA. GA is easy to parallelize because of its SIMD nature and therefore can be implemented well on GPGPU. Thus, speedup can definitely be achieved if bottleneck in GAs are identified and implemented effectively on GPGPU. Paper gives review of various applications solved using GAs on GPGPU with the future scope in the area of optimization.

  12. Geographical parthenogenesis: General purpose genotypes and frozen niche variation

    DEFF Research Database (Denmark)

    Vrijenhoek, Robert C.; Parker, Dave

    2009-01-01

    marginal environments to escape competition with their sexual relatives. These ideas often fail to consider the early competitive interactions with immediate sexual ancestors, which shape alternative paths that newly formed clonal lineages might follow. Here we review the history and evidence for two...... hypotheses concerning the evolution of niche breadth in asexual species - the "general-purpose genotype" (GPG) and "frozen niche-variation" (FNV) models. The two models are often portrayed as mutually exclusive, respectively viewing clonal lineages as generalists versus specialists. Nonetheless......, they are complex syllogisms that share common assumptions regarding the likely origins of clonal diversity and the strength of interclonal selection in shaping the ecological breadth of asexual populations. Both models find support in ecological and phylogeographic studies of a wide range of organisms...

  13. SNAP: A General Purpose Network Analysis and Graph Mining Library

    CERN Document Server

    Leskovec, Jure

    2016-01-01

    Large networks are becoming a widely used abstraction for studying complex systems in a broad set of disciplines, ranging from social network analysis to molecular biology and neuroscience. Despite an increasing need to analyze and manipulate large networks, only a limited number of tools are available for this task. Here, we describe Stanford Network Analysis Platform (SNAP), a general-purpose, high-performance system that provides easy to use, high-level operations for analysis and manipulation of large networks. We present SNAP functionality, describe its implementational details, and give performance benchmarks. SNAP has been developed for single big-memory machines and it balances the trade-off between maximum performance, compact in-memory graph representation, and the ability to handle dynamic graphs where nodes and edges are being added or removed over time. SNAP can process massive networks with hundreds of millions of nodes and billions of edges. SNAP offers over 140 different graph algorithms that ...

  14. A Chemical Containment Model for the General Purpose Work Station

    Science.gov (United States)

    Flippen, Alexis A.; Schmidt, Gregory K.

    1994-01-01

    Contamination control is a critical safety requirement imposed on experiments flying on board the Spacelab. The General Purpose Work Station, a Spacelab support facility used for life sciences space flight experiments, is designed to remove volatile compounds from its internal airpath and thereby minimize contamination of the Spacelab. This is accomplished through the use of a large, multi-stage filter known as the Trace Contaminant Control System. Many experiments planned for the Spacelab require the use of toxic, volatile fixatives in order to preserve specimens prior to postflight analysis. The NASA-Ames Research Center SLS-2 payload, in particular, necessitated the use of several toxic, volatile compounds in order to accomplish the many inflight experiment objectives of this mission. A model was developed based on earlier theories and calculations which provides conservative predictions of the resultant concentrations of these compounds given various spill scenarios. This paper describes the development and application of this model.

  15. General purpose multiplexing device for cryogenic microwave systems

    Science.gov (United States)

    Chapman, Benjamin J.; Moores, Bradley A.; Rosenthal, Eric I.; Kerckhoff, Joseph; Lehnert, K. W.

    2016-05-01

    We introduce and experimentally characterize a general purpose device for signal processing in circuit quantum electrodynamics systems. The device is a broadband two-port microwave circuit element with three modes of operation: it can transmit, reflect, or invert incident signals between 4 and 8 GHz. This property makes it a versatile tool for lossless signal processing at cryogenic temperatures. In particular, rapid switching (≤ 15 ns ) between these operation modes enables several multiplexing readout protocols for superconducting qubits. We report the device's performance in a two-channel code domain multiplexing demonstration. The multiplexed data are recovered with fast readout times (up to 400 ns ) and infidelities ≤ 10-2 for probe powers ≥ 7 fW , in agreement with the expectation for binary signaling with Gaussian noise.

  16. Toward a General-Purpose Heterogeneous Ensemble for Pattern Classification

    Directory of Open Access Journals (Sweden)

    Loris Nanni

    2015-01-01

    Full Text Available We perform an extensive study of the performance of different classification approaches on twenty-five datasets (fourteen image datasets and eleven UCI data mining datasets. The aim is to find General-Purpose (GP heterogeneous ensembles (requiring little to no parameter tuning that perform competitively across multiple datasets. The state-of-the-art classifiers examined in this study include the support vector machine, Gaussian process classifiers, random subspace of adaboost, random subspace of rotation boosting, and deep learning classifiers. We demonstrate that a heterogeneous ensemble based on the simple fusion by sum rule of different classifiers performs consistently well across all twenty-five datasets. The most important result of our investigation is demonstrating that some very recent approaches, including the heterogeneous ensemble we propose in this paper, are capable of outperforming an SVM classifier (implemented with LibSVM, even when both kernel selection and SVM parameters are carefully tuned for each dataset.

  17. Toward a General-Purpose Heterogeneous Ensemble for Pattern Classification.

    Science.gov (United States)

    Nanni, Loris; Brahnam, Sheryl; Ghidoni, Stefano; Lumini, Alessandra

    2015-01-01

    We perform an extensive study of the performance of different classification approaches on twenty-five datasets (fourteen image datasets and eleven UCI data mining datasets). The aim is to find General-Purpose (GP) heterogeneous ensembles (requiring little to no parameter tuning) that perform competitively across multiple datasets. The state-of-the-art classifiers examined in this study include the support vector machine, Gaussian process classifiers, random subspace of adaboost, random subspace of rotation boosting, and deep learning classifiers. We demonstrate that a heterogeneous ensemble based on the simple fusion by sum rule of different classifiers performs consistently well across all twenty-five datasets. The most important result of our investigation is demonstrating that some very recent approaches, including the heterogeneous ensemble we propose in this paper, are capable of outperforming an SVM classifier (implemented with LibSVM), even when both kernel selection and SVM parameters are carefully tuned for each dataset.

  18. General-purpose event generators for LHC physics

    CERN Document Server

    Buckley, Andy; Gieseke, Stefan; Grellscheid, David; Hoche, Stefan; Hoeth, Hendrik; Krauss, Frank; Lonnblad, Leif; Nurse, Emily; Richardson, Peter; Schumann, Steffen; Seymour, Michael H; Sjostrand, Torbjorn; Skands, Peter; Webber, Bryan

    2011-01-01

    We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard-scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond-Standard-Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators ...

  19. Using a cognitive architecture for general purpose service robot control

    Science.gov (United States)

    Puigbo, Jordi-Ysard; Pumarola, Albert; Angulo, Cecilio; Tellez, Ricardo

    2015-04-01

    A humanoid service robot equipped with a set of simple action skills including navigating, grasping, recognising objects or people, among others, is considered in this paper. By using those skills the robot should complete a voice command expressed in natural language encoding a complex task (defined as the concatenation of a number of those basic skills). As a main feature, no traditional planner has been used to decide skills to be activated, as well as in which sequence. Instead, the SOAR cognitive architecture acts as the reasoner by selecting which action the robot should complete, addressing it towards the goal. Our proposal allows to include new goals for the robot just by adding new skills (without the need to encode new plans). The proposed architecture has been tested on a human-sized humanoid robot, REEM, acting as a general purpose service robot.

  20. The purpose of the general practice consultation from the patients perspective - theoretical aspects

    DEFF Research Database (Denmark)

    Thorsen, Hanne; Witt, Klaus; Malterud, Kirsti

    2001-01-01

    Consultation purposes, general practice, patients´expectations, patients satosfaction, patientcenteredness......Consultation purposes, general practice, patients´expectations, patients satosfaction, patientcenteredness...

  1. Use of general purpose graphics processing units with MODFLOW.

    Science.gov (United States)

    Hughes, Joseph D; White, Jeremy T

    2013-01-01

    To evaluate the use of general-purpose graphics processing units (GPGPUs) to improve the performance of MODFLOW, an unstructured preconditioned conjugate gradient (UPCG) solver has been developed. The UPCG solver uses a compressed sparse row storage scheme and includes Jacobi, zero fill-in incomplete, and modified-incomplete lower-upper (LU) factorization, and generalized least-squares polynomial preconditioners. The UPCG solver also includes options for sequential and parallel solution on the central processing unit (CPU) using OpenMP. For simulations utilizing the GPGPU, all basic linear algebra operations are performed on the GPGPU; memory copies between the central processing unit CPU and GPCPU occur prior to the first iteration of the UPCG solver and after satisfying head and flow criteria or exceeding a maximum number of iterations. The efficiency of the UPCG solver for GPGPU and CPU solutions is benchmarked using simulations of a synthetic, heterogeneous unconfined aquifer with tens of thousands to millions of active grid cells. Testing indicates GPGPU speedups on the order of 2 to 8, relative to the standard MODFLOW preconditioned conjugate gradient (PCG) solver, can be achieved when (1) memory copies between the CPU and GPGPU are optimized, (2) the percentage of time performing memory copies between the CPU and GPGPU is small relative to the calculation time, (3) high-performance GPGPU cards are utilized, and (4) CPU-GPGPU combinations are used to execute sequential operations that are difficult to parallelize. Furthermore, UPCG solver testing indicates GPGPU speedups exceed parallel CPU speedups achieved using OpenMP on multicore CPUs for preconditioners that can be easily parallelized. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

  2. General-purpose event generators for LHC physics

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, Andy [PPE Group, School of Physics and Astronomy, University of Edinburgh, EH25 9PN (United Kingdom); Butterworth, Jonathan [Department of Physics and Astronomy, University College London, WC1E 6BT (United Kingdom); Gieseke, Stefan [Institute for Theoretical Physics, Karlsruhe Institute of Technology, D-76128 Karlsruhe (Germany); Grellscheid, David [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Hoeche, Stefan [SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Hoeth, Hendrik; Krauss, Frank [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Loennblad, Leif [Department of Astronomy and Theoretical Physics, Lund University (Sweden); PH Department, TH Unit, CERN, CH-1211 Geneva 23 (Switzerland); Nurse, Emily [Department of Physics and Astronomy, University College London, WC1E 6BT (United Kingdom); Richardson, Peter [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Schumann, Steffen [Institute for Theoretical Physics, University of Heidelberg, 69120 Heidelberg (Germany); Seymour, Michael H. [School of Physics and Astronomy, University of Manchester, M13 9PL (United Kingdom); Sjoestrand, Torbjoern [Department of Astronomy and Theoretical Physics, Lund University (Sweden); Skands, Peter [PH Department, TH Unit, CERN, CH-1211 Geneva 23 (Switzerland); Webber, Bryan, E-mail: webber@hep.phy.cam.ac.uk [Cavendish Laboratory, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

    2011-07-15

    We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond Standard Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists seeking a deeper insight into the tools available for signal and background simulation at the LHC.

  3. High-Speed General Purpose Genetic Algorithm Processor.

    Science.gov (United States)

    Hoseini Alinodehi, Seyed Pourya; Moshfe, Sajjad; Saber Zaeimian, Masoumeh; Khoei, Abdollah; Hadidi, Khairollah

    2016-07-01

    In this paper, an ultrafast steady-state genetic algorithm processor (GAP) is presented. Due to the heavy computational load of genetic algorithms (GAs), they usually take a long time to find optimum solutions. Hardware implementation is a significant approach to overcome the problem by speeding up the GAs procedure. Hence, we designed a digital CMOS implementation of GA in [Formula: see text] process. The proposed processor is not bounded to a specific application. Indeed, it is a general-purpose processor, which is capable of performing optimization in any possible application. Utilizing speed-boosting techniques, such as pipeline scheme, parallel coarse-grained processing, parallel fitness computation, parallel selection of parents, dual-population scheme, and support for pipelined fitness computation, the proposed processor significantly reduces the processing time. Furthermore, by relying on a built-in discard operator the proposed hardware may be used in constrained problems that are very common in control applications. In the proposed design, a large search space is achievable through the bit string length extension of individuals in the genetic population by connecting the 32-bit GAPs. In addition, the proposed processor supports parallel processing, in which the GAs procedure can be run on several connected processors simultaneously.

  4. General-purpose event generators for LHC physics

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, Andy; /Edinburgh U.; Butterworth, Jonathan; /University Coll. London; Gieseke, Stefan; /Karlsruhe U., ITP; Grellscheid, David; /Durham U., IPPP; Hoche, Stefan; /SLAC; Hoeth, Hendrik; Krauss, Frank; /Durham U., IPPP; Lonnblad, Leif; /Lund U., Dept. Theor. Phys. /CERN; Nurse, Emily; /University Coll. London; Richardson, Peter; /Durham U., IPPP; Schumann, Steffen; /Heidelberg U.; Seymour, Michael H.; /Manchester U.; Sjostrand, Torbjorn; /Lund U., Dept. Theor. Phys.; Skands, Peter; /CERN; Webber, Bryan; /Cambridge U.

    2011-03-03

    We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard-scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond-Standard-Model processes. We describe the principal features of the Ariadne, Herwig++, Pythia 8 and Sherpa generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists wanting a deeper insight into the tools available for signal and background simulation at the LHC.

  5. Foam A General Purpose Cellular Monte Carlo Event Generator

    CERN Document Server

    Jadach, Stanislaw

    2003-01-01

    A general purpose, self-adapting, Monte Carlo (MC) event generator (simulator) is described. The high efficiency of the MC, that is small maximum weight or variance of the MC weight is achieved by means of dividing the integration domain into small cells. The cells can be $n$-dimensional simplices, hyperrectangles or Cartesian product of them. The grid of cells, called ``foam'', is produced in the process of the binary split of the cells. The choice of the next cell to be divided and the position/direction of the division hyper-plane is driven by the algorithm which optimizes the ratio of the maximum weight to the average weight or (optionally) the total variance. The algorithm is able to deal, in principle, with an arbitrary pattern of the singularities in the distribution. As any MC generator, it can also be used for the MC integration. With the typical personal computer CPU, the program is able to perform adaptive integration/simulation at relatively small number of dimensions ($\\leq 16$). With the continu...

  6. Generalized Fluid System Simulation Program (GFSSP) Version 6 - General Purpose Thermo-Fluid Network Analysis Software

    Science.gov (United States)

    Majumdar, Alok; Leclair, Andre; Moore, Ric; Schallhorn, Paul

    2011-01-01

    GFSSP stands for Generalized Fluid System Simulation Program. It is a general-purpose computer program to compute pressure, temperature and flow distribution in a flow network. GFSSP calculates pressure, temperature, and concentrations at nodes and calculates flow rates through branches. It was primarily developed to analyze Internal Flow Analysis of a Turbopump Transient Flow Analysis of a Propulsion System. GFSSP development started in 1994 with an objective to provide a generalized and easy to use flow analysis tool for thermo-fluid systems.

  7. SNAP: A General Purpose Network Analysis and Graph Mining Library.

    Science.gov (United States)

    Leskovec, Jure; Sosič, Rok

    2016-10-01

    Large networks are becoming a widely used abstraction for studying complex systems in a broad set of disciplines, ranging from social network analysis to molecular biology and neuroscience. Despite an increasing need to analyze and manipulate large networks, only a limited number of tools are available for this task. Here, we describe Stanford Network Analysis Platform (SNAP), a general-purpose, high-performance system that provides easy to use, high-level operations for analysis and manipulation of large networks. We present SNAP functionality, describe its implementational details, and give performance benchmarks. SNAP has been developed for single big-memory machines and it balances the trade-off between maximum performance, compact in-memory graph representation, and the ability to handle dynamic graphs where nodes and edges are being added or removed over time. SNAP can process massive networks with hundreds of millions of nodes and billions of edges. SNAP offers over 140 different graph algorithms that can efficiently manipulate large graphs, calculate structural properties, generate regular and random graphs, and handle attributes and meta-data on nodes and edges. Besides being able to handle large graphs, an additional strength of SNAP is that networks and their attributes are fully dynamic, they can be modified during the computation at low cost. SNAP is provided as an open source library in C++ as well as a module in Python. We also describe the Stanford Large Network Dataset, a set of social and information real-world networks and datasets, which we make publicly available. The collection is a complementary resource to our SNAP software and is widely used for development and benchmarking of graph analytics algorithms.

  8. CLOUDCLOUD : general-purpose instrument monitoring and data managing software

    Science.gov (United States)

    Dias, António; Amorim, António; Tomé, António

    2016-04-01

    An effective experiment is dependent on the ability to store and deliver data and information to all participant parties regardless of their degree of involvement in the specific parts that make the experiment a whole. Having fast, efficient and ubiquitous access to data will increase visibility and discussion, such that the outcome will have already been reviewed several times, strengthening the conclusions. The CLOUD project aims at providing users with a general purpose data acquisition, management and instrument monitoring platform that is fast, easy to use, lightweight and accessible to all participants of an experiment. This work is now implemented in the CLOUD experiment at CERN and will be fully integrated with the experiment as of 2016. Despite being used in an experiment of the scale of CLOUD, this software can also be used in any size of experiment or monitoring station, from single computers to large networks of computers to monitor any sort of instrument output without influencing the individual instrument's DAQ. Instrument data and meta data is stored and accessed via a specially designed database architecture and any type of instrument output is accepted using our continuously growing parsing application. Multiple databases can be used to separate different data taking periods or a single database can be used if for instance an experiment is continuous. A simple web-based application gives the user total control over the monitored instruments and their data, allowing data visualization and download, upload of processed data and the ability to edit existing instruments or add new instruments to the experiment. When in a network, new computers are immediately recognized and added to the system and are able to monitor instruments connected to them. Automatic computer integration is achieved by a locally running python-based parsing agent that communicates with a main server application guaranteeing that all instruments assigned to that computer are

  9. SPIDR, a general-purpose readout system for pixel ASICs

    Science.gov (United States)

    van der Heijden, B.; Visser, J.; van Beuzekom, M.; Boterenbrood, H.; Kulis, S.; Munneke, B.; Schreuder, F.

    2017-02-01

    The SPIDR (Speedy PIxel Detector Readout) system is a flexible general-purpose readout platform that can be easily adapted to test and characterize new and existing detector readout ASICs. It is originally designed for the readout of pixel ASICs from the Medipix/Timepix family, but other types of ASICs or front-end circuits can be read out as well. The SPIDR system consists of an FPGA board with memory and various communication interfaces, FPGA firmware, CPU subsystem and an API library on the PC . The FPGA firmware can be adapted to read out other ASICs by re-using IP blocks. The available IP blocks include a UDP packet builder, 1 and 10 Gigabit Ethernet MAC's and a "soft core" CPU . Currently the firmware is targeted at the Xilinx VC707 development board and at a custom board called Compact-SPIDR . The firmware can easily be ported to other Xilinx 7 series and ultra scale FPGAs. The gap between an ASIC and the data acquisition back-end is bridged by the SPIDR system. Using the high pin count VITA 57 FPGA Mezzanine Card (FMC) connector only a simple chip carrier PCB is required. A 1 and a 10 Gigabit Ethernet interface handle the connection to the back-end. These can be used simultaneously for high-speed data and configuration over separate channels. In addition to the FMC connector, configurable inputs and outputs are available for synchronization with other detectors. A high resolution (≈ 27 ps bin size) Time to Digital converter is provided for time stamping events in the detector. The SPIDR system is frequently used as readout for the Medipix3 and Timepix3 ASICs. Using the 10 Gigabit Ethernet interface it is possible to read out a single chip at full bandwidth or up to 12 chips at a reduced rate. Another recent application is the test-bed for the VeloPix ASIC, which is developed for the Vertex Detector of the LHCb experiment. In this case the SPIDR system processes the 20 Gbps scrambled data stream from the VeloPix and distributes it over four 10 Gigabit

  10. A Heuristic Framework to Solve a General Delivery Problem

    Science.gov (United States)

    Lian, Lian; Castelain, Emmanuel

    2010-06-01

    This paper presents a new distribution and route planning problem, General Delivery Problem (GDP) which is more general than the well-known Vehicle Routing Problem. To solve a GDP, a three-phase framework heuristic approach based on decomposition techniques is introduced. The decomposition techniques are employed to divide an original problem into a set of sub-problems, which can reduce the problem size. A kind of decomposition technique, Capacity Clustering Algorithm (CCA), is embedded into the framework with Simulated Annealing (SA) to solve a special GDP. The proposed three-phase framework with the above two algorithms is compared with five other decomposition methods in a distribution instance of the Regional Fire and Emergency Center in the north of France.

  11. General Economic Equilibrium: Purpose, Analytic Techniques, Collective Choice

    Science.gov (United States)

    The lecture is designed to survey modern development of the theory of general equilibrium in a competitive economy and its role in the allocation of...by an evaluation of the needs for further development. The differing general equilibrium tradition in the German-language literature is summarized.

  12. RoboCon: A general purpose telerobotic control center

    Energy Technology Data Exchange (ETDEWEB)

    Draper, J.V.; Noakes, M.W. [Oak Ridge National Lab., TN (United States). Robotics and Process Systems Div.; Schempf, H. [Carnegie Mellon Univ., Pittsburgh, PA (United States); Blair, L.M. [Human Machine Interfaces, Inc., Knoxville, TN (United States)

    1997-02-01

    This report describes human factors issues involved in the design of RoboCon, a multi-purpose control center for use in US Department of Energy remote handling applications. RoboCon is intended to be a flexible, modular control center capable of supporting a wide variety of robotic devices.

  13. Intraoperative awareness during general anesthesia for cesarean delivery.

    Science.gov (United States)

    Robins, Kay; Lyons, Gordon

    2009-09-01

    Intraoperative awareness is defined as the spontaneous recall of an event occurring during general anesthesia. A move away from rigid anesthetic protocols, which were designed to limit drug transmission across the placenta, has reduced the incidence of awareness during cesarean delivery to approximately 0.26%. Nevertheless, it remains an undesirable complication with potential for the development of posttraumatic stress disorder. Assessing depth of anesthesia remains a challenge for the anesthesia provider as clinical signs are unreliable and there is no sensitive and specific monitor. Bispectral Index monitoring with the goal of scores awareness. Induction drugs vary in their ability to produce amnesia and the period of hypnotic effect is affected by the rate at which they are redistributed. After initiation of anesthesia, volatile anesthetics should be administered to a target of 0.7 minimum alveolar anesthetic concentration, which has been shown to consistently achieve mean Bispectral Index scores awareness during emergency cesarean delivery. In the absence of fetal compromise, there is no rationale for an inspired oxygen concentration above 0.33. Deeper levels of anesthesia reduce the incidence of awareness; current evidence does not suggest an increased risk of tocolysis or fetal morbidity.

  14. SOME GENERAL ASPECTS OF ENGLISH FOR SPECIFIC PURPOSES

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The teaching of English for Specific Purposes has been in existence for over 30 years,and has beenprominence for more than 20 years,and is still in the ascendant.ESP teaching accounts for a consider-able proportion of the teaching of English as a foreign language in China.It is therefore necessary forus Chinese teacher s to know more about ESP.

  15. 7 CFR 248.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Special Supplemental Nutrition Program for Women, Infants and Children (WIC) or are on the waiting list... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1...

  16. 7 CFR 1940.551 - Purpose and general policy.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) GENERAL Methodology and Formulas for Allocation of Loan and Grant Program... methodology and formulas by which the Administrator of the Farmers Home Administration (FmHA) or its successor...

  17. GASP: A general-purpose program for environmental alpha spectra

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, A.M.; Tome, F.V.; Vargas, M.J. (Dept. de Fisica, Univ. de Extremadura, Badajoz (Spain))

    1992-02-01

    A computer program to study general environmental alpha-particle emission spectra obtained by using semiconductor detectors is described. Each alpha-emitting nuclide is analysed following a method which is suited to its case. Low-energy tail and branching-ratio corrections are included so that the area corresponding to each nuclide in the spectrum is obtained separately. Calculations are not iterative, and so the program is economic in its use of computer time and memory. (orig.).

  18. General Purpose Segmentation for Microorganisms in Microscopy Images

    DEFF Research Database (Denmark)

    Jensen, Sebastian H. Nesgaard; Moeslund, Thomas B.; Rankl, Christian

    2014-01-01

    In this paper, we propose an approach for achieving generalized segmentation of microorganisms in mi- croscopy images. It employs a pixel-wise classification strategy based on local features. Multilayer percep- trons are utilized for classification of the local features and is trained for each...... specific segmentation problem using supervised learning. This approach was tested on five different segmentation problems in bright field, differential interference contrast, fluorescence and laser confocal scanning microscopy. In all instance good results were achieved with the segmentation quality...

  19. Lactic acid bacteria: reviewing the potential of a promising delivery live vector for biomedical purposes.

    Science.gov (United States)

    Cano-Garrido, Olivia; Seras-Franzoso, Joaquin; Garcia-Fruitós, Elena

    2015-09-16

    Lactic acid bacteria (LAB) have a long history of safe exploitation by humans, being used for centuries in food production and preservation and as probiotic agents to promote human health. Interestingly, some species of these Gram-positive bacteria, which are generally recognized as safe organisms by the US Food and Drug Administration (FDA), are able to survive through the gastrointestinal tract (GIT), being capable to reach and colonize the intestine, where they play an important role. Besides, during the last decades, an important effort has been done for the development of tools to use LAB as microbial cell factories for the production of proteins of interest. Given the need to develop effective strategies for the delivery of prophylactic and therapeutic molecules, LAB have appeared as an appealing option for the oral, intranasal and vaginal delivery of such molecules. So far, these genetically modified organisms have been successfully used as vehicles for delivering functional proteins to mucosal tissues in the treatment of many different pathologies including GIT related pathologies, diabetes, cancer and viral infections, among others. Interestingly, the administration of such microorganisms would suppose a significant decrease in the production cost of the treatments agents since being live organisms, such vectors would be able to autonomously amplify and produce and deliver the protein of interest. In this context, this review aims to provide an overview of the use of LAB engineered as a promising alternative as well as a safety delivery platform of recombinant proteins for the treatment of a wide range of diseases.

  20. Recent technical advances in general purpose mobile Satcom aviation terminals

    Science.gov (United States)

    Sydor, John T.

    A second general aviation amplitude companded single sideband (ACSSB) aeronautical terminal was developed for use with the Ontario Air Ambulance Service (OAAS). This terminal is designed to have automatic call set up and take down and to interface with the Public Service Telephone Network (PSTN) through a ground earth station hub controller. The terminal has integrated RF and microprocessor hardware which allows such functions as beam steering and automatic frequency control to be software controlled. The terminal uses a conformal patch array system to provide almost full azimuthal coverage. Antenna beam steering is executed without relying on aircraft supplied orientation information.

  1. Recent technical advances in general purpose mobile Satcom aviation terminals

    Science.gov (United States)

    Sydor, John T.

    1990-01-01

    A second general aviation amplitude companded single sideband (ACSSB) aeronautical terminal was developed for use with the Ontario Air Ambulance Service (OAAS). This terminal is designed to have automatic call set up and take down and to interface with the Public Service Telephone Network (PSTN) through a ground earth station hub controller. The terminal has integrated RF and microprocessor hardware which allows such functions as beam steering and automatic frequency control to be software controlled. The terminal uses a conformal patch array system to provide almost full azimuthal coverage. Antenna beam steering is executed without relying on aircraft supplied orientation information.

  2. PD5: a general purpose library for primer design software.

    Science.gov (United States)

    Riley, Michael C; Aubrey, Wayne; Young, Michael; Clare, Amanda

    2013-01-01

    Complex PCR applications for large genome-scale projects require fast, reliable and often highly sophisticated primer design software applications. Presently, such applications use pipelining methods to utilise many third party applications and this involves file parsing, interfacing and data conversion, which is slow and prone to error. A fully integrated suite of software tools for primer design would considerably improve the development time, the processing speed, and the reliability of bespoke primer design software applications. The PD5 software library is an open-source collection of classes and utilities, providing a complete collection of software building blocks for primer design and analysis. It is written in object-oriented C(++) with an emphasis on classes suitable for efficient and rapid development of bespoke primer design programs. The modular design of the software library simplifies the development of specific applications and also integration with existing third party software where necessary. We demonstrate several applications created using this software library that have already proved to be effective, but we view the project as a dynamic environment for building primer design software and it is open for future development by the bioinformatics community. Therefore, the PD5 software library is published under the terms of the GNU General Public License, which guarantee access to source-code and allow redistribution and modification. The PD5 software library is downloadable from Google Code and the accompanying Wiki includes instructions and examples: http://code.google.com/p/primer-design.

  3. General purpose flow solver applied to flow over hills

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, N.N.

    1995-09-01

    The present report describes the development a 2D and 3D finite-volume code in general curvilinear coordinates using the Basis 2D/3D platform by Michelsen. The codes are based on the Reynolds averaged incompressible isothermal Navier-Stokes equations and use primitive variables (U, V, W and P). The turbulence is modelled by the high Reynolds number {kappa} - {epsilon} model. Cartesian velocity components are used in a non-staggered arrangement following the methodology of Rhie. The equation system is solved using the SIMPLE method of Patankar and Spalding. Solution of the transport equations is obtained by a successive application of a TDMA solver in alternating direction. The solution of the pressure correction equation is accelerated using the multigrid tools from the Basis 2D/3D platform. Additionally a three-level grid sequence is implemented in order to minimize the overall solution time. Higher-order schemes (SUDS and QUICK) are implemented as explicit corrections to a first-order upwind difference scheme. In both the 2D and the 3D code it is possible to handle multiblock configurations. This feature is added in order to obtain a greater geometric flexibility. To mesh natural terrain in connection with atmospheric flow over complex terrain, a two- and a three-dimensional hyperbolic mesh generator are constructed. Additionally, a two- and a three-dimensional mesh generator based on a simple version of the transfinite interpolation technique are implemented. Several two-dimensional test cases are calculated e.g. laminar flow over a circular cylinder, turbulent channel flow, and turbulent flow over a backward facing step, all with satisfying results. In order to illustrate the application of the codes to atmospheric flow two cases are calculated, flow over a cube in a thick turbulent boundary-layer, and the atmospheric flow over the Askervein hill. (au) 13 tabs., 75 ills., 66 refs.

  4. A Comprehensive Toolset for General-Purpose Private Computing and Outsourcing

    Science.gov (United States)

    2016-12-08

    AFRL-AFOSR-VA-TR-2016-0368 A COMPREHENSIVE TOOLSET FOR GENERAL-PURPOSE PRIVATE COMPUTING AND OUTSOURCING Marina Blanton UNIVERSITY OF NOTRE DAME DU...2013 to 31 Aug 2016 4. TITLE AND SUBTITLE A COMPREHENSIVE TOOLSET FOR GENERAL-PURPOSE PRIVATE COMPUTING AND OUTSOURCING 5a.  CONTRACT NUMBER 5b...necessary tools and techniques for supporting general-purpose secure computation and outsourcing . The three main thrusts of the project are: (i

  5. 78 FR 65300 - Notice of Availability (NOA) for General Purpose Warehouse and Information Technology Center...

    Science.gov (United States)

    2013-10-31

    ...: Federal Docket Management System Office, 4800 Mark Center Drive, East Tower, 2nd floor, Suite 02G09... of the Secretary Notice of Availability (NOA) for General Purpose Warehouse and Information... Purpose Warehouse and Information Technology Center at Defense Distribution Depot San Joaquin,...

  6. The delivery of general paediatric surgery in Ireland: a survey of higher surgical trainees.

    LENUS (Irish Health Repository)

    Boyle, E

    2012-12-01

    The delivery of general paediatric surgery is changing in Ireland. Fewer paediatric surgical procedures are being performed by newly appointed consultant general surgeons, resulting in increased referrals to the specialist paediatric surgeons of uncomplicated general paediatric surgical problems. We surveyed current higher surgical trainees about their views on provision of paediatric surgical services.

  7. 24 CFR 990.310 - Purpose-General policy on financial management, monitoring and reporting.

    Science.gov (United States)

    2010-04-01

    ... Management Systems, Monitoring, and Reporting § 990.310 Purpose—General policy on financial management, monitoring and reporting. All PHA financial management systems, reporting, and monitoring of program... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Purpose-General policy on...

  8. 21 CFR 1240.80 - General requirements for water for drinking and culinary purposes.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false General requirements for water for drinking and... DRUG ADMINISTRATION CONTROL OF COMMUNICABLE DISEASES Source and Use of Potable Water § 1240.80 General requirements for water for drinking and culinary purposes. Only potable water shall be provided for...

  9. Apple-CORE: harnessing general-purpose many-cores with hardware concurrency management

    NARCIS (Netherlands)

    Poss, R.; Lankamp, M.; Yang, Q.; Fu, J.; van Tol, M.W.; Uddin, I.; Jesshope, C.

    2013-01-01

    To harness the potential of CMPs for scalable, energy-efficient performance in general-purpose computers, the Apple-CORE project has co-designed a general machine model and concurrency control interface with dedicated hardware support for concurrency management across multiple cores. Its SVP interfa

  10. Re-Purposing of Content and Digital Delivery Convergence: Implications for Interface Design.

    Science.gov (United States)

    Milekic, Slavko

    With the introduction of the digital medium, an abundance of content previously obtainable through other media became available in digital form. Digital delivery implied the necessity for some kind of content modification dictated by the specific characteristics of the digital medium. The situation is further complicated by the convergence of…

  11. Design of low-cost general purpose microcontroller based neuromuscular stimulator.

    Science.gov (United States)

    Koçer, S; Rahmi Canal, M; Güler, I

    2000-04-01

    In this study, a general purpose, low-cost, programmable, portable and high performance stimulator is designed and implemented. For this purpose, a microcontroller is used in the design of the stimulator. The duty cycle and amplitude of the designed system can be controlled using a keyboard. The performance test of the system has shown that the results are reliable. The overall system can be used as the neuromuscular stimulator under safe conditions.

  12. An Investigation of Learning Transfer in English-for-General-Academic-Purposes Writing Instruction

    Science.gov (United States)

    James, Mark Andrew

    2010-01-01

    This case study involved a detailed examination of learning transfer from an English-for-general-academic-purposes writing course to tasks that involve writing in other academic courses. Data were gathered over one academic year from 11 students enrolled in the writing course. These students participated in a series of interviews and provided…

  13. A general purpose exact Rayleigh scattering look-up table for ocean color remote sensing

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The current exact Rayleigh scattering calculation of ocean color remote sensing uses the look-up table (LUT), which is usually created for a special remote sensor and cannot be applied to other sensors. For practical application, a general purpose Rayleigh scattering LUT which can be applied to all ocean color remote sensors is generated. An adding-doubling method to solve the vector radiative transfer equation in the plane-parallel atmosphere is deduced in detail. Compared with the exact Rayleigh scattering radiance derived from the MODIS exact Rayleigh scattering LUT, it is proved that the relative error of Rayleigh scattering calculation with the adding-doubling method is less than 0.25%, which meets the required accuracy of the atmospheric correction of ocean color remote sensing. Therefore,the adding-doubling method can be used to generate the exact Rayleigh scattering LUT for the ocean color remote sensors. Finally, the general purpose exact Rayleigh scattering LUT is generated using the adding-doubling method. On the basis of the general purpose LUT, the calculated Rayleigh scattering radiance is tested by comparing with the LUTs of MODIS, SeaWiFS and the other ocean color sensors, showing that the relative errors are all less than 0.5%, and this general purpose LUT can be applied to all ocean color remote sensors.

  14. Implementing the 2-D Wavelet Transform on SIMD-Enhanced General-Purpose Processors

    NARCIS (Netherlands)

    Shahbahrami, A.; Juurlink, B.; Vassiliadis, S.

    2008-01-01

    The 2-D Discrete Wavelet Transform (DWT) consumes up to 68% of the JPEG2000 encoding time. In this paper, we develop efficient implementations of this important kernel on general-purpose processors (GPPs), in particular the Pentium 4 (P4). Efficient implementations of the 2-D DWT on the P4 must addr

  15. JETSET: Physics at LEAR with an Internal Gas Jet Target and an Advanced General Purpose Detector

    CERN Multimedia

    2002-01-01

    This experiment involves an internal gas cluster jet target surrounded by a compact general-purpose detector. The LEAR beam and internal jet target provide several important experimental features: high luminosity $ ( 10 ^{3} ^0 $ cm$^- ^{2} $ sec$^- ^{1} ) $, excellent mass resolution ($\\Delta

  16. 21 CFR 862.2050 - General purpose laboratory equipment labeled or promoted for a specific medical use.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false General purpose laboratory equipment labeled or... TOXICOLOGY DEVICES Clinical Laboratory Instruments § 862.2050 General purpose laboratory equipment labeled or promoted for a specific medical use. (a) Identification. General purpose laboratory equipment labeled...

  17. General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering.

    Science.gov (United States)

    Mout, Rubul; Ray, Moumita; Tay, Tristan; Sasaki, Kanae; Yesilbag Tonga, Gulen; Rotello, Vincent M

    2017-06-27

    Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of proteins to the cytosol through co-engineering of proteins and nanoparticle vehicles. The proteins feature an oligo(glutamate) sequence (E-tag) that binds arginine-functionalized gold nanoparticles, generating hierarchical spherical nanoassemblies. These assemblies fuse with cell membranes, releasing the E-tagged protein directly into the cytosol. Five different proteins with diverse charges, sizes, and functions were effectively delivered into cells, demonstrating the generality of our method. Significantly, the engineered proteins retained activity after cytosolic delivery, as demonstrated through the delivery of active Cre recombinase, and granzyme A to kill cancer cells.

  18. Real-time radar signal processing using GPGPU (general-purpose graphic processing unit)

    Science.gov (United States)

    Kong, Fanxing; Zhang, Yan Rockee; Cai, Jingxiao; Palmer, Robert D.

    2016-05-01

    This study introduces a practical approach to develop real-time signal processing chain for general phased array radar on NVIDIA GPUs(Graphical Processing Units) using CUDA (Compute Unified Device Architecture) libraries such as cuBlas and cuFFT, which are adopted from open source libraries and optimized for the NVIDIA GPUs. The processed results are rigorously verified against those from the CPUs. Performance benchmarked in computation time with various input data cube sizes are compared across GPUs and CPUs. Through the analysis, it will be demonstrated that GPGPUs (General Purpose GPU) real-time processing of the array radar data is possible with relatively low-cost commercial GPUs.

  19. General Purpose Satellites: a concept for affordable low earth orbit vehicles

    OpenAIRE

    Boyd, Austin W.; Fuhs, Allen E.

    1997-01-01

    A general purpose satellite has been designed which will be launched from the Space Shuttle using a NASA Get-Away-Special (GAS) canister. The design is based upon the use of a new extended GAS canister and a low profile launch mechanism. The satellite is cylindrical. measuring 19 inches in diameter and 35 inches long. The maximum vehicle weight is 250 pounds, of which 50 pounds is dedicated to user payloads. The remaining 200 pounds encompasses the satellite structure and support ...

  20. Comparison of progressive addition lenses for general purpose and for computer vision: an office field study.

    Science.gov (United States)

    Jaschinski, Wolfgang; König, Mirjam; Mekontso, Tiofil M; Ohlendorf, Arne; Welscher, Monique

    2015-05-01

    Two types of progressive addition lenses (PALs) were compared in an office field study: 1. General purpose PALs with continuous clear vision between infinity and near reading distances and 2. Computer vision PALs with a wider zone of clear vision at the monitor and in near vision but no clear distance vision. Twenty-three presbyopic participants wore each type of lens for two weeks in a double-masked four-week quasi-experimental procedure that included an adaptation phase (Weeks 1 and 2) and a test phase (Weeks 3 and 4). Questionnaires on visual and musculoskeletal conditions as well as preferences regarding the type of lenses were administered. After eight more weeks of free use of the spectacles, the preferences were assessed again. The ergonomic conditions were analysed from photographs. Head inclination when looking at the monitor was significantly lower by 2.3 degrees with the computer vision PALs than with the general purpose PALs. Vision at the monitor was judged significantly better with computer PALs, while distance vision was judged better with general purpose PALs; however, the reported advantage of computer vision PALs differed in extent between participants. Accordingly, 61 per cent of the participants preferred the computer vision PALs, when asked without information about lens design. After full information about lens characteristics and additional eight weeks of free spectacle use, 44 per cent preferred the computer vision PALs. On average, computer vision PALs were rated significantly better with respect to vision at the monitor during the experimental part of the study. In the final forced-choice ratings, approximately half of the participants preferred either the computer vision PAL or the general purpose PAL. Individual factors seem to play a role in this preference and in the rated advantage of computer vision PALs. © 2015 The Authors. Clinical and Experimental Optometry © 2015 Optometry Australia.

  1. Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/ Drug-delivery Vehicles in Current Medicine.

    Science.gov (United States)

    Mariyam, Merina; Ghosal, Kajal; George, Anne; Thomas, Sabu; Kalarikkal, Nandakumar; S Latha, Mahima

    2017-05-11

    Dendrimers are hyper branched macro molecules with well-defined structure and high degree of functionality on the surface. The dendrimer architecture allows control over properties such as shape, size, density, polarity, reactivity, solubility etc. This can be manipulated to design molecules with desired properties in biomedical applications. Recent advancement in correlating structure to biodegradability and invivo performance opens up new avenue for these molecules in biological applications like drug delivery and tissue engineering. The unique structure of dendrimers provides enough attachment sites for drugs in drug delivery applications. It is possible to tune the molecule in such a way as to encapsulate drug molecule outside target area and release in the local environment of targets. This review presents the general aspects of dendrimers and how these properties are exploited for drug delivery applications. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  2. Literature Review: Weldability of Iridium DOP-26 Alloy for General Purpose Heat Source

    Energy Technology Data Exchange (ETDEWEB)

    Burgardt, Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pierce, Stanley W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-19

    The basic purpose of this paper is to provide a literature review relative to fabrication of the General Purpose Heat Source (GPHS) that is used to provide electrical power for deep space missions of NASA. The particular fabrication operation to be addressed here is arc welding of the GPHS encapsulation. A considerable effort was made to optimize the fabrication of the fuel pellets and of other elements of the encapsulation; that work will not be directly addressed in this paper. This report consists of three basic sections: 1) a brief description of the GPHS will be provided as background information for the reader; 2) mechanical properties and the optimization thereof as relevant to welding will be discussed; 3) a review of the arc welding process development and optimization will be presented. Since the welding equipment must be upgraded for future production, some discussion of the historical establishment of relevant welding variables and possible changes thereto will also be discussed.

  3. Biosafety of non-surface modified carbon nanocapsules as a potential alternative to carbon nanotubes for drug delivery purposes.

    Directory of Open Access Journals (Sweden)

    Alan C L Tang

    Full Text Available BACKGROUND: Carbon nanotubes (CNTs have found wide success in circuitry, photovoltaics, and other applications. In contrast, several hurdles exist in using CNTs towards applications in drug delivery. Raw, non-modified CNTs are widely known for their toxicity. As such, many have attempted to reduce CNT toxicity for intravenous drug delivery purposes by post-process surface modification. Alternatively, a novel sphere-like carbon nanocapsule (CNC developed by the arc-discharge method holds similar electric and thermal conductivities, as well as high strength. This study investigated the systemic toxicity and biocompatibility of different non-surface modified carbon nanomaterials in mice, including multi-walled carbon nanotubes (MWCNTs, single-walled carbon nanotubes (SWCNTs, carbon nanocapsules (CNCs, and C ₆₀ fullerene (C ₆₀. The retention of the nanomaterials and systemic effects after intravenous injections were studied. METHODOLOGY AND PRINCIPAL FINDINGS: MWCNTs, SWCNTs, CNCs, and C ₆₀ were injected intravenously into FVB mice and then sacrificed for tissue section examination. Inflammatory cytokine levels were evaluated with ELISA. Mice receiving injection of MWCNTs or SWCNTs at 50 µg/g b.w. died while C ₆₀ injected group survived at a 50% rate. Surprisingly, mortality rate of mice injected with CNCs was only at 10%. Tissue sections revealed that most carbon nanomaterials retained in the lung. Furthermore, serum and lung-tissue cytokine levels did not reveal any inflammatory response compared to those in mice receiving normal saline injection. CONCLUSION: Carbon nanocapsules are more biocompatible than other carbon nanomaterials and are more suitable for intravenous drug delivery. These results indicate potential biomedical use of non-surface modified carbon allotrope. Additionally, functionalization of the carbon nanocapsules could further enhance dispersion and biocompatibility for intravenous injection.

  4. General purpose pulse shape analysis for fast scintillators implemented in digital readout electronics

    Science.gov (United States)

    Asztalos, Stephen J.; Hennig, Wolfgang; Warburton, William K.

    2016-01-01

    Pulse shape discrimination applied to certain fast scintillators is usually performed offline. In sufficiently high-event rate environments data transfer and storage become problematic, which suggests a different analysis approach. In response, we have implemented a general purpose pulse shape analysis algorithm in the XIA Pixie-500 and Pixie-500 Express digital spectrometers. In this implementation waveforms are processed in real time, reducing the pulse characteristics to a few pulse shape analysis parameters and eliminating time-consuming waveform transfer and storage. We discuss implementation of these features, their advantages, necessary trade-offs and performance. Measurements from bench top and experimental setups using fast scintillators and XIA processors are presented.

  5. Development of a Real-Time General-Purpose Digital Signal Processing Laboratory System.

    Science.gov (United States)

    1983-12-01

    for AF/LE computer support (receiving the Air Force Meritorious Service Medal for his performance) and ,I as a White House Social Aide. He entered AFIT...8217 " ’"".i2" ",. , , ,: ., 2 22 : Abstract This investigation resulted in the design and implementation of software to support a real-time, general...purpose digital signal processing (DSP) system. The major design aims for the system were that it: be easy to use, support a wide variety of DSP

  6. Knowledge Management Systems as an Interdisciplinary Communication and Personalized General-Purpose Technology

    Directory of Open Access Journals (Sweden)

    Ulrich Schmitt

    2015-10-01

    Full Text Available As drivers of human civilization, Knowledge Management (KM processes have co-evolved in line with General-Purpose-Technologies (GPT, such as writing, printing, and information and communication systems. As evidenced by the recent shift from information scarcity to abundance, GPTs are capable of drastically altering societies due to their game-changing impact on our spheres of work and personal development. This paper looks at the prospect of whether a novel Personal Knowledge Management (PKM concept supported by a prototype system has got what it takes to grow into a transformative General-Purpose-Technology. Following up on a series of papers, the KM scenario of a decentralizing revolution where individuals and self-organized groups yield more power and autonomy is examined according to a GPT's essential characteristics, including a wide scope for improvement and elaboration (in people's private, professional and societal life, applicability across a broad range of uses in a wide variety of products and processes (in multi-disciplinary educational and work contexts, and strong complementarities with existing or potential new technologies (like organizational KM Systems and a proposed World Heritage of Memes Repository. The result portrays the PKM concept as a strong candidate due to its personal, autonomous, bottom-up, collaborative, interdisciplinary, and creativity-supporting approach destined to advance the availability, quantity, and quality of the world extelligence and to allow for a wider sharing and faster diffusion of ideas across current disciplinary and opportunity divides.

  7. General Purpose Data-Driven Online System Health Monitoring with Applications to Space Operations

    Science.gov (United States)

    Iverson, David L.; Spirkovska, Lilly; Schwabacher, Mark

    2010-01-01

    Modern space transportation and ground support system designs are becoming increasingly sophisticated and complex. Determining the health state of these systems using traditional parameter limit checking, or model-based or rule-based methods is becoming more difficult as the number of sensors and component interactions grows. Data-driven monitoring techniques have been developed to address these issues by analyzing system operations data to automatically characterize normal system behavior. System health can be monitored by comparing real-time operating data with these nominal characterizations, providing detection of anomalous data signatures indicative of system faults, failures, or precursors of significant failures. The Inductive Monitoring System (IMS) is a general purpose, data-driven system health monitoring software tool that has been successfully applied to several aerospace applications and is under evaluation for anomaly detection in vehicle and ground equipment for next generation launch systems. After an introduction to IMS application development, we discuss these NASA online monitoring applications, including the integration of IMS with complementary model-based and rule-based methods. Although the examples presented in this paper are from space operations applications, IMS is a general-purpose health-monitoring tool that is also applicable to power generation and transmission system monitoring.

  8. General-purpose and dedicated regimes in the use of telescopes

    CERN Document Server

    Lamy, Jerome

    2009-01-01

    We propose a sociohistorical framework for better understanding the evolution in the use of telescopes. We define two regimes of use : a general-purpose (or survey) one, where the telescope governs research, and a dedicated one, in which the telescope is tailored to a specific project which includes a network of other tools. This conceptual framework is first applied to the history of the 80-cm telescope of Toulouse Observatory, which is initially anchored in a general-purpose regime linked to astrometry. After a transition in the 1930s, it is integrated in a dedicated regime centered on astrophysics. This evolution is compared to that of a very similar instrument, the 80-cm telescope of Marseille Observatory, which converts early on to the dedicated regime with the Fabry-Perot interferometer around 1910, and, after a period of idleness, is again used in the survey mode after WWII. To further validate our new concept, we apply it to the telescopes of Washburn Observatory, of Dominion Astrophysical Observatory...

  9. Neural Networks for Computer Vision: A Framework for Specifications of a General Purpose Vision System

    Science.gov (United States)

    Skrzypek, Josef; Mesrobian, Edmond; Gungner, David J.

    1989-03-01

    The development of autonomous land vehicles (ALV) capable of operating in an unconstrained environment has proven to be a formidable research effort. The unpredictability of events in such an environment calls for the design of a robust perceptual system, an impossible task requiring the programming of a system bases on the expectation of future, unconstrained events. Hence, the need for a "general purpose" machine vision system that is capable of perceiving and understanding images in an unconstrained environment in real-time. The research undertaken at the UCLA Machine Perception Laboratory addresses this need by focusing on two specific issues: 1) the long term goals for machine vision research as a joint effort between the neurosciences and computer science; and 2) a framework for evaluating progress in machine vision. In the past, vision research has been carried out independently within different fields including neurosciences, psychology, computer science, and electrical engineering. Our interdisciplinary approach to vision research is based on the rigorous combination of computational neuroscience, as derived from neurophysiology and neuropsychology, with computer science and electrical engineering. The primary motivation behind our approach is that the human visual system is the only existing example of a "general purpose" vision system and using a neurally based computing substrate, it can complete all necessary visual tasks in real-time.

  10. An evaluation of alternate production methods for Pu-238 general purpose heat source pellets

    Energy Technology Data Exchange (ETDEWEB)

    Mark Borland; Steve Frank

    2009-06-01

    For the past half century, the National Aeronautics and Space Administration (NASA) has used Radioisotope Thermoelectric Generators (RTG) to power deep space satellites. Fabricating heat sources for RTGs, specifically General Purpose Heat Sources (GPHSs), has remained essentially unchanged since their development in the 1970s. Meanwhile, 30 years of technological advancements have been made in the applicable fields of chemistry, manufacturing and control systems. This paper evaluates alternative processes that could be used to produce Pu 238 fueled heat sources. Specifically, this paper discusses the production of the plutonium-oxide granules, which are the input stream to the ceramic pressing and sintering processes. Alternate chemical processes are compared to current methods to determine if alternative fabrication processes could reduce the hazards, especially the production of respirable fines, while producing an equivalent GPHS product.

  11. General Purpose Graphics Processing Unit Based High-Rate Rice Decompression and Reed-Solomon Decoding.

    Energy Technology Data Exchange (ETDEWEB)

    Loughry, Thomas A.

    2015-02-01

    As the volume of data acquired by space-based sensors increases, mission data compression/decompression and forward error correction code processing performance must likewise scale. This competency development effort was explored using the General Purpose Graphics Processing Unit (GPGPU) to accomplish high-rate Rice Decompression and high-rate Reed-Solomon (RS) decoding at the satellite mission ground station. Each algorithm was implemented and benchmarked on a single GPGPU. Distributed processing across one to four GPGPUs was also investigated. The results show that the GPGPU has considerable potential for performing satellite communication Data Signal Processing, with three times or better performance improvements and up to ten times reduction in cost over custom hardware, at least in the case of Rice Decompression and Reed-Solomon Decoding.

  12. Real-time traffic sign recognition based on a general purpose GPU and deep-learning

    Science.gov (United States)

    Hong, Yongwon; Choi, Yeongwoo; Byun, Hyeran

    2017-01-01

    We present a General Purpose Graphics Processing Unit (GPGPU) based real-time traffic sign detection and recognition method that is robust against illumination changes. There have been many approaches to traffic sign recognition in various research fields; however, previous approaches faced several limitations when under low illumination or wide variance of light conditions. To overcome these drawbacks and improve processing speeds, we propose a method that 1) is robust against illumination changes, 2) uses GPGPU-based real-time traffic sign detection, and 3) performs region detecting and recognition using a hierarchical model. This method produces stable results in low illumination environments. Both detection and hierarchical recognition are performed in real-time, and the proposed method achieves 0.97 F1-score on our collective dataset, which uses the Vienna convention traffic rules (Germany and South Korea). PMID:28264011

  13. Simrank: Rapid and sensitive general-purpose k-mer search tool

    Energy Technology Data Exchange (ETDEWEB)

    DeSantis, T.Z.; Keller, K.; Karaoz, U.; Alekseyenko, A.V; Singh, N.N.S.; Brodie, E.L; Pei, Z.; Andersen, G.L; Larsen, N.

    2011-04-01

    Terabyte-scale collections of string-encoded data are expected from consortia efforts such as the Human Microbiome Project (http://nihroadmap.nih.gov/hmp). Intra- and inter-project data similarity searches are enabled by rapid k-mer matching strategies. Software applications for sequence database partitioning, guide tree estimation, molecular classification and alignment acceleration have benefited from embedded k-mer searches as sub-routines. However, a rapid, general-purpose, open-source, flexible, stand-alone k-mer tool has not been available. Here we present a stand-alone utility, Simrank, which allows users to rapidly identify database strings the most similar to query strings. Performance testing of Simrank and related tools against DNA, RNA, protein and human-languages found Simrank 10X to 928X faster depending on the dataset. Simrank provides molecular ecologists with a high-throughput, open source choice for comparing large sequence sets to find similarity.

  14. Developing wearable bio-feedback systems: a general-purpose platform.

    Science.gov (United States)

    Bianchi, Luigi; Babiloni, Fabio; Cincotti, Febo; Arrivas, Marco; Bollero, Patrizio; Marciani, Maria Grazia

    2003-06-01

    Microprocessors, even those in PocketPCs, have adequate power for many real-time biofeedback applications for disabled people. This power allows design of portable or wearable devices that are smaller and lighter, and that have longer battery life compared to notebook-based systems. In this paper, we discuss a general-purpose hardware/software solution based on industrial or consumer devices and a C++ framework. Its flexibility and modularity make it adaptable to a wide range of situations. Moreover, its design minimizes system requirements and programming effort, thus allowing efficient systems to be built quickly and easily. Our design has been used to build two brain computer interface systems that were easily ported from the Win32 platform.

  15. Upgrade of the Cellular General Purpose Monte Carlo Tool FOAM to version 2.06

    CERN Document Server

    Jadach, Stanislaw

    2006-01-01

    FOAM-2.06 is an upgraded version of FOAM, a general purpose, self-adapting Monte Carlo event generator. In comparison with FOAM-2.05, it has two important improvements. New interface to random numbers lets the user to choose from the three "state of the art" random number generators. Improved algorithms for simplical grid need less computer memory; the problem of the prohibitively large memory allocation required for the large number ($>10^6$) of simplical cells is now eliminated -- the new version can handle such cases even on the average desktop computers. In addition, generation of the Monte Carlo events, in case of large number of cells, may be even significantly faster.

  16. Design and Implementation of 3D Model Database for General-Purpose 3D GIS

    Institute of Scientific and Technical Information of China (English)

    XU Weiping; ZHU Qing; DU Zhiqiang; ZHANG Yeting

    2010-01-01

    To improve the reusability of three-dimensional (3D) models and simplify the complexity of natural scene reconstruction, this paper presents a 3D model database for universal 3D GIS. After the introduction of its extensible function architecture,accompanied by the conclusion of implicit spatial-temporal hierarchy of models in any reconstructed scene of 3D GIS for general purpose, several key issues are discussed in detail, such as the storage and management of 3D models and related retrieval and load method, as well as the interfaces for further on-demand development. Finally, the validity and feasibility of this model database are proved through its application in the development of 3D visualization system of railway operation.

  17. GPACC program cost work breakdown structure-dictionary. General purpose aft cargo carrier study, volume 3

    Science.gov (United States)

    1985-01-01

    The results of detailed cost estimates and economic analysis performed on the updated Model 101 configuration of the general purpose Aft Cargo Carrier (ACC) are given. The objective of this economic analysis is to provide the National Aeronautics and Space Administration (NASA) with information on the economics of using the ACC on the Space Transportation System (STS). The detailed cost estimates for the ACC are presented by a work breakdown structure (WBS) to ensure that all elements of cost are considered in the economic analysis and related subsystem trades. Costs reported by WBS provide NASA with a basis for comparing competing designs and provide detailed cost information that can be used to forecast phase C/D planning for new projects or programs derived from preliminary conceptual design studies. The scope covers all STS and STS/ACC launch vehicle cost impacts for delivering payloads to a 160 NM low Earth orbit (LEO).

  18. A General Purpose Connections type CTI Server Based on SIP Protocol and Its Implementation

    Science.gov (United States)

    Watanabe, Toru; Koizumi, Hisao

    In this paper, we propose a general purpose connections type CTI (Computer Telephony Integration) server that provides various CTI services such as voice logging where the CTI server communicates with IP-PBX using the SIP (Session Initiation Protocol), and accumulates voice packets of external line telephone call flowing between an IP telephone for extension and a VoIP gateway connected to outside line networks. The CTI server realizes CTI services such as voice logging, telephone conference, or IVR (interactive voice response) with accumulating and processing voice packets sampled. Furthermore, the CTI server incorporates a web server function which can provide various CTI services such as a Web telephone directory via a Web browser to PCs, cellular telephones or smart-phones in mobile environments.

  19. Fully implicit mixed-hybrid finite-element discretization for general purpose subsurface reservoir simulation

    Science.gov (United States)

    Abushaikha, Ahmad S.; Voskov, Denis V.; Tchelepi, Hamdi A.

    2017-10-01

    We present a new fully-implicit, mixed-hybrid, finite-element (MHFE) discretization scheme for general-purpose compositional reservoir simulation. The locally conservative scheme solves the coupled momentum and mass balance equations simultaneously, and the fluid system is modeled using a cubic equation-of-state. We introduce a new conservative flux approach for the mass balance equations for this fully-implicit approach. We discuss the nonlinear solution procedure for the proposed approach, and we present extensive numerical tests to demonstrate the convergence and accuracy of the MHFE method using tetrahedral elements. We also compare the method to other advanced discretization schemes for unstructured meshes and tensor permeability. Finally, we illustrate the applicability and robustness of the method for highly heterogeneous reservoirs with unstructured grids.

  20. Litrani a General Purpose Monte-Carlo Program Simulating Light Propagation In Isotropic or Anisotropic Media

    CERN Document Server

    Gentit, François-Xavier

    2001-01-01

    Litrani is a general purpose Monte-Carlo program simulating light propagation in any type of setup describable by the shapes provided by ROOT. Each shape may be made of a different material. Dielectric constant, absorption length and diffusion length of materials may depend upon wavelength. Dielectric constant and absorption length may be anisotropic. Each face of a volume is either partially or totally in contact with a face of another volume, or covered with some wrapping having defined characteristics of absorption, reflection and diffusion. When in contact with another face of another volume, the possibility exists to have a thin slice of width d and index n between the 2 faces. The program has various sources of light: spontaneous photons, photons coming from an optical fibre, photons generated by the crossing of particles or photons generated by an electromagnetic shower. The time and wavelength spectra of emitted photons may reproduce any scintillation spectrum. As detectors, phototubes, APD, or any ge...

  1. A general purpose subroutine for fast fourier transform on a distributed memory parallel machine

    Science.gov (United States)

    Dubey, A.; Zubair, M.; Grosch, C. E.

    1992-01-01

    One issue which is central in developing a general purpose Fast Fourier Transform (FFT) subroutine on a distributed memory parallel machine is the data distribution. It is possible that different users would like to use the FFT routine with different data distributions. Thus, there is a need to design FFT schemes on distributed memory parallel machines which can support a variety of data distributions. An FFT implementation on a distributed memory parallel machine which works for a number of data distributions commonly encountered in scientific applications is presented. The problem of rearranging the data after computing the FFT is also addressed. The performance of the implementation on a distributed memory parallel machine Intel iPSC/860 is evaluated.

  2. A General Purpose Feature Extractor for Light Detection and Ranging Data

    Directory of Open Access Journals (Sweden)

    Edwin B. Olson

    2010-11-01

    Full Text Available Feature extraction is a central step of processing Light Detection and Ranging (LIDAR data. Existing detectors tend to exploit characteristics of specific environments: corners and lines from indoor (rectilinear environments, and trees from outdoor environments. While these detectors work well in their intended environments, their performance in different environments can be poor. We describe a general purpose feature detector for both 2D and 3D LIDAR data that is applicable to virtually any environment. Our method adapts classic feature detection methods from the image processing literature, specifically the multi-scale Kanade-Tomasi corner detector. The resulting method is capable of identifying highly stable and repeatable features at a variety of spatial scales without knowledge of environment, and produces principled uncertainty estimates and corner descriptors at same time. We present results on both software simulation and standard datasets, including the 2D Victoria Park and Intel Research Center datasets, and the 3D MIT DARPA Urban Challenge dataset.

  3. A Real-Time Programmer's Tour of General-Purpose L4 Microkernels

    Directory of Open Access Journals (Sweden)

    Ruocco Sergio

    2008-01-01

    Full Text Available Abstract L4-embedded is a microkernel successfully deployed in mobile devices with soft real-time requirements. It now faces the challenges of tightly integrated systems, in which user interface, multimedia, OS, wireless protocols, and even software-defined radios must run on a single CPU. In this paper we discuss the pros and cons of L4-embedded for real-time systems design, focusing on the issues caused by the extreme speed optimisations it inherited from its general-purpose ancestors. Since these issues can be addressed with a minimal performance loss, we conclude that, overall, the design of real-time systems based on L4-embedded is possible, and facilitated by a number of design features unique to microkernels and the L4 family.

  4. Generic functional requirements for a NASA general-purpose data base management system

    Science.gov (United States)

    Lohman, G. M.

    1981-01-01

    Generic functional requirements for a general-purpose, multi-mission data base management system (DBMS) for application to remotely sensed scientific data bases are detailed. The motivation for utilizing DBMS technology in this environment is explained. The major requirements include: (1) a DBMS for scientific observational data; (2) a multi-mission capability; (3) user-friendly; (4) extensive and integrated information about data; (5) robust languages for defining data structures and formats; (6) scientific data types and structures; (7) flexible physical access mechanisms; (8) ways of representing spatial relationships; (9) a high level nonprocedural interactive query and data manipulation language; (10) data base maintenance utilities; (11) high rate input/output and large data volume storage; and adaptability to a distributed data base and/or data base machine configuration. Detailed functions are specified in a top-down hierarchic fashion. Implementation, performance, and support requirements are also given.

  5. General-purpose heat source safety verification test series: SVT-7 through SVT-10

    Science.gov (United States)

    George, T. G.; Pavone, D.

    1985-09-01

    The General-Purpose Heat Source (GPHS) is a modular component of the radioisotope thermoelectric generator that will supply power for the Galileo and Ulysses (formerly ISPM) space missions. The GPHS provides power by transmitting the heat of (238)PuO2 (ALPHA)-decay to an array of thermoelectric elements. Because the possibility of an orbital abort always exists, the heat source was designed and constructed to minimize plutonia release in any accident environment. The Safety Verification Test (SVT) series was formulated to evaluate the effectiveness of GPHS plutonia containment after atmospheric reentry and Earth impact. The first report (covering SVT-1 through SVT-6) described the results of flat and side-on module impacts. This report describes module impacts at angles of 15(0) and 30(0).

  6. General-purpose heat source safety verification test series: SVT-11 through SVT-13

    Science.gov (United States)

    George, T. G.; Pavone, D.

    1986-05-01

    The General-Purpose Heat Source (GPHS) is a modular component of the radioisotope thermoelectric generator that will provide power for the Galileo and Ulysses (formerly ISPM) space missions. The GPHS provides power by transmitting the heat of Pu -decay to an array of thermoelectric elements. Because the possibility of an orbital abort always exists, the heat source was designed and constructed to minimize plutonia release in any accident environment. The Safety Verification Test (SVT) series was formulated to evaluate the effectiveness of GPHS plutonia containment after atmospheric reentry and Earth impact. The first two reports (covering SVT-1 through SVT-10) described the results of flat, side-on, and angular module impacts against steel targets at 54 m/s. This report describes flat-on module impacts against concrete and granite targets, at velocities equivalent to or higher than previous SVTs.

  7. General Purpose Graphics Processing Unit Based High-Rate Rice Decompression and Reed-Solomon Decoding

    Energy Technology Data Exchange (ETDEWEB)

    Loughry, Thomas A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-01

    As the volume of data acquired by space-based sensors increases, mission data compression/decompression and forward error correction code processing performance must likewise scale. This competency development effort was explored using the General Purpose Graphics Processing Unit (GPGPU) to accomplish high-rate Rice Decompression and high-rate Reed-Solomon (RS) decoding at the satellite mission ground station. Each algorithm was implemented and benchmarked on a single GPGPU. Distributed processing across one to four GPGPUs was also investigated. The results show that the GPGPU has considerable potential for performing satellite communication Data Signal Processing, with three times or better performance improvements and up to ten times reduction in cost over custom hardware, at least in the case of Rice Decompression and Reed-Solomon Decoding.

  8. A Parallel General Purpose Mulit-Objective Optimization Framework, with Application to Beam Dynamics

    CERN Document Server

    Ineichen, Y; Kolano, A; Bekas, C; Curioni, A; Arbenz, P

    2013-01-01

    Particle accelerators are invaluable tools for research in the basic and applied sciences, in fields such as materials science, chemistry, the biosciences, particle physics, nuclear physics and medicine. The design, commissioning, and operation of accelerator facilities is a non-trivial task, due to the large number of control parameters and the complex interplay of several conflicting design goals. We propose to tackle this problem by means of multi-objective optimization algorithms which also facilitate a parallel deployment. In order to compute solutions in a meaningful time frame we require a fast and scalable software framework. In this paper, we present the implementation of such a general-purpose framework for simulation based multi-objective optimization methods that allows the automatic investigation of optimal sets of machine parameters. The implementation is based on a master/slave paradigm, employing several masters that govern a set of slaves executing simulations and performing optimization task...

  9. Design of the SLAC RCE Platform: A General Purpose ATCA Based Data Acquisition System

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, R. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Claus, R. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Freytag, M. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Haller, G. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Huffer, M. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Maldonado, S. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Nishimura, K. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; O' Grady, C. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Panetta, J. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Perazzo, A. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Reese, B. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Ruckman, L. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Thayer, J. G. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.; Weaver, M. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Research Engineering Div.

    2015-01-23

    The SLAC RCE platform is a general purpose clustered data acquisition system implemented on a custom ATCA compliant blade, called the Cluster On Board (COB). The core of the system is the Reconfigurable Cluster Element (RCE), which is a system-on-chip design based upon the Xilinx Zynq family of FPGAs, mounted on custom COB daughter-boards. The Zynq architecture couples a dual core ARM Cortex A9 based processor with a high performance 28nm FPGA. The RCE has 12 external general purpose bi-directional high speed links, each supporting serial rates of up to 12Gbps. 8 RCE nodes are included on a COB, each with a 10Gbps connection to an on-board 24-port Ethernet switch integrated circuit. The COB is designed to be used with a standard full-mesh ATCA backplane allowing multiple RCE nodes to be tightly interconnected with minimal interconnect latency. Multiple shelves can be clustered using the front panel 10-gbps connections. The COB also supports local and inter-blade timing and trigger distribution. An experiment specific Rear Transition Module adapts the 96 high speed serial links to specific experiments and allows an experiment-specific timing and busy feedback connection. This coupling of processors with a high performance FPGA fabric in a low latency, multiple node cluster allows high speed data processing that can be easily adapted to any physics experiment. RTEMS and Linux are both ported to the module. The RCE has been used or is the baseline for several current and proposed experiments (LCLS, HPS, LSST, ATLAS-CSC, LBNE, DarkSide, ILC-SiD, etc).

  10. Transforming the ASDEX Upgrade discharge control system to a general-purpose plasma control platform

    Energy Technology Data Exchange (ETDEWEB)

    Treutterer, Wolfgang, E-mail: Wolfgang.Treutterer@ipp.mpg.de [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Cole, Richard [Unlimited Computer Systems, Seeshaupter Str. 15, 82393 Iffeldorf (Germany); Gräter, Alexander [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Lüddecke, Klaus [Unlimited Computer Systems, Seeshaupter Str. 15, 82393 Iffeldorf (Germany); Neu, Gregor; Rapson, Christopher; Raupp, Gerhard; Zasche, Dieter; Zehetbauer, Thomas [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany)

    2015-10-15

    Highlights: • Control framework split in core and custom part. • Core framework deployable in other fusion device environments. • Adaptible through customizable modules, plug-in support and generic interfaces. - Abstract: The ASDEX Upgrade Discharge Control System DCS is a modern and mature product, originally designed to regulate and supervise ASDEX Upgrade Tokamak plasma operation. In its core DCS is based on a generic, versatile real-time software framework with a plugin architecture that allows to easily combine, modify and extend control function modules in order to tailor the system to required features and let it continuously evolve with the progress of an experimental fusion device. Due to these properties other fusion experiments like the WEST project have expressed interest in adopting DCS. For this purpose, essential parts of DCS must be unpinned from the ASDEX Upgrade environment by exposure or introduction of generalised interfaces. Re-organisation of DCS modules allows distinguishing between intrinsic framework core functions and device-specific applications. In particular, DCS must be prepared for deployment in different system environments with their own realisations for user interface, pulse schedule preparation, parameter server, time and event distribution, diagnostic and actuator systems, network communication and data archiving. The article explains the principles of the revised DCS structure, derives the necessary interface definitions and describes major steps to achieve the separation between general-purpose framework and fusion device specific components.

  11. Optimization of a general-purpose, actively scanned proton beamline for ocular treatments: Geant4 simulations.

    Science.gov (United States)

    Piersimoni, Pierluigi; Rimoldi, Adele; Riccardi, Cristina; Pirola, Michele; Molinelli, Silvia; Ciocca, Mario

    2015-03-08

    The Italian National Center for Hadrontherapy (CNAO, Centro Nazionale di Adroterapia Oncologica), a synchrotron-based hospital facility, started the treatment of patients within selected clinical trials in late 2011 and 2012 with actively scanned proton and carbon ion beams, respectively. The activation of a new clinical protocol for the irradiation of uveal melanoma using the existing general-purpose proton beamline is foreseen for late 2014. Beam characteristics and patient treatment setup need to be tuned to meet the specific requirements for such a type of treatment technique. The aim of this study is to optimize the CNAO transport beamline by adding passive components and minimizing air gap to achieve the optimal conditions for ocular tumor irradiation. The CNAO setup with the active and passive components along the transport beamline, as well as a human eye-modeled detector also including a realistic target volume, were simulated using the Monte Carlo Geant4 toolkit. The strong reduction of the air gap between the nozzle and patient skin, as well as the insertion of a range shifter plus a patient-specific brass collimator at a short distance from the eye, were found to be effective tools to be implemented. In perspective, this simulation toolkit could also be used as a benchmark for future developments and testing purposes on commercial treatment planning systems.

  12. Corrosion science general-purpose data model and interface (Ⅲ):Data integration and management environment

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A brand new Corrosion Data Integration and Management Environment(CDIME) is developed in Java programming language based on general-purpose corrosion data model(GPCDM) and corrosion data markup language(CDML) proposed in the previous works.In general,the functionalities and features of CDIME meet most of design requirements including composition,inheritance,self-contained,relatively independence and so on.An insight tutorial is introduced on the life circle of corrosion data islands from its creation,maintenance,and application like publishing.The template feature makes the building of comprehensive data island as simple as a few mouse clicks.Read-only publishing of data as e-Book and PDF hold their own places.Achieved document can be imported and exported freely on any running CDIME.The achieving feature is addressed in detail because it is critical to data sharing and integration in GPCDM.At the end,a real example is presented to help the understanding of data islands assembling and the advanced features offered by CDIME.

  13. Corrosion science general-purpose data model and interface (Ⅲ): Data integration and management environment

    Institute of Scientific and Technical Information of China (English)

    TANG ZiLong

    2008-01-01

    A brand new Corrosion Data Integration and Management Environment (CDIME) is developed in Java programming language based on general-purpose corrosion data model (GPCDM) and corrosion data markup language (CDML) proposed in the previous works. In general, the functionalities and features of CDIME meet most of design requirements including composition, inheritance, self-contained, relatively independence and so on. An insight tutorial is introduced on the life circle of cor-rosion data islands from its creation, maintenance, and application like publishing. The template feature makes the building of comprehensive data island as simple as a few mouse clicks. Read-only publishing of data as e-Book and PDF hold their own places. Achieved document can be imported and exported freely on any running CDIME. The achieving feature is addressed in detail because it is critical to data sharing and integration in GPCDM. At the end, a real example is presented to help the understanding of data islands assembling and the advanced features offered by CDIME.

  14. The PennBMBI: Design of a General Purpose Wireless Brain-Machine-Brain Interface System.

    Science.gov (United States)

    Liu, Xilin; Zhang, Milin; Subei, Basheer; Richardson, Andrew G; Lucas, Timothy H; Van der Spiegel, Jan

    2015-04-01

    In this paper, a general purpose wireless Brain-Machine-Brain Interface (BMBI) system is presented. The system integrates four battery-powered wireless devices for the implementation of a closed-loop sensorimotor neural interface, including a neural signal analyzer, a neural stimulator, a body-area sensor node and a graphic user interface implemented on the PC end. The neural signal analyzer features a four channel analog front-end with configurable bandpass filter, gain stage, digitization resolution, and sampling rate. The target frequency band is configurable from EEG to single unit activity. A noise floor of 4.69 μVrms is achieved over a bandwidth from 0.05 Hz to 6 kHz. Digital filtering, neural feature extraction, spike detection, sensing-stimulating modulation, and compressed sensing measurement are realized in a central processing unit integrated in the analyzer. A flash memory card is also integrated in the analyzer. A 2-channel neural stimulator with a compliance voltage up to ± 12 V is included. The stimulator is capable of delivering unipolar or bipolar, charge-balanced current pulses with programmable pulse shape, amplitude, width, pulse train frequency and latency. A multi-functional sensor node, including an accelerometer, a temperature sensor, a flexiforce sensor and a general sensor extension port has been designed. A computer interface is designed to monitor, control and configure all aforementioned devices via a wireless link, according to a custom designed communication protocol. Wireless closed-loop operation between the sensory devices, neural stimulator, and neural signal analyzer can be configured. The proposed system was designed to link two sites in the brain, bridging the brain and external hardware, as well as creating new sensory and motor pathways for clinical practice. Bench test and in vivo experiments are performed to verify the functions and performances of the system.

  15. Auxiliary subsystems of a General-Purpose IGBT Stack for high-performance laboratory power converters

    Indian Academy of Sciences (India)

    ANIL KUMAR ADAPA; D VENKATRAMANAN; VINOD JOHN

    2017-08-01

    A PWM converter is the prime component in many power electronic applications such as static UPS, electric motor drives, power quality conditioners and renewable-energy-based power generation systems. While there are a number of computer simulation tools available today for studying power electronic systems,the value added by the experience of building a power converter and controlling it to function as desired is unparalleled. A student, in the process, not only understands power electronic concepts better, but also gains insights into other essential engineering aspects of auxiliary subsystems such as start-up, sensing, protection, circuit layout design, mechanical arrangement and system integration. Higher levels of protection features are critical for the converters used in a laboratory environment, as advanced protection schemes could prevent unanticipated failures occurring during the course of research. This paper presents a laboratory-built General-Purpose IGBT Stack (GPIS), which facilitates students to practically realize different power converter topologies. Essential subsystems for a complete power converter system is presented covering details of semiconductor device driving, sensing circuit, protection mechanism, system start-up, relaying and critical PCB layout design, followed by a brief comparison to commercially available IGBT stacks. The results show the high performance that can be obtained by the GPIS converter.

  16. deconSTRUCT: general purpose protein database search on the substructure level.

    Science.gov (United States)

    Zhang, Zong Hong; Bharatham, Kavitha; Sherman, Westley A; Mihalek, Ivana

    2010-07-01

    deconSTRUCT webserver offers an interface to a protein database search engine, usable for a general purpose detection of similar protein (sub)structures. Initially, it deconstructs the query structure into its secondary structure elements (SSEs) and reassembles the match to the target by requiring a (tunable) degree of similarity in the direction and sequential order of SSEs. Hierarchical organization and judicious use of the information about protein structure enables deconSTRUCT to achieve the sensitivity and specificity of the established search engines at orders of magnitude increased speed, without tying up irretrievably the substructure information in the form of a hash. In a post-processing step, a match on the level of the backbone atoms is constructed. The results presented to the user consist of the list of the matched SSEs, the transformation matrix for rigid superposition of the structures and several ways of visualization, both downloadable and implemented as a web-browser plug-in. The server is available at http://epsf.bmad.bii.a-star.edu.sg/struct_server.html.

  17. Design-for-Testability Features and Test Implementation of a Giga Hertz General Purpose Microprocessor

    Institute of Scientific and Technical Information of China (English)

    Da Wang; Yu Hu; Hua-Wei Li; Xiao-Wei Li

    2008-01-01

    This paper describes the design-for-testability (DFT) features and low-cost testing solutions of a general purpose microprocessor. The optimized DFT features are presented in detail. A hybrid scan compression structure was executed and achieved compression ratio more than ten times. Memory built-in self-test (BIST) circuitries were designed with scan collars instead of bitmaps to reduce area overheads and to improve test and debug efficiency. The implemented DFT framework also utilized internal phase-locked loops (PLL) to provide complex at-speed test clock sequences. Since there are still limitations in this DFT design, the test strategies for this case are quite complex, with complicated automatic test pattern generation (ATPG) and debugging flow. The sample testing results are given in the paper. All the DFT methods discussed in the paper are prototypes for a high-volume manufacturing (HVM) DFT plan to meet high quality test goals as well as slow test power consumption and cost.

  18. Foam Multi-Dimensional General Purpose Monte Carlo Generator With Self-Adapting Symplectic Grid

    CERN Document Server

    Jadach, Stanislaw

    2000-01-01

    A new general purpose Monte Carlo event generator with self-adapting grid consisting of simplices is described. In the process of initialization, the simplex-shaped cells divide into daughter subcells in such a way that: (a) cell density is biggest in areas where integrand is peaked, (b) cells elongate themselves along hyperspaces where integrand is enhanced/singular. The grid is anisotropic, i.e. memory of the axes directions of the primary reference frame is lost. In particular, the algorithm is capable of dealing with distributions featuring strong correlation among variables (like ridge along diagonal). The presented algorithm is complementary to others known and commonly used in the Monte Carlo event generators. It is, in principle, more effective then any other one for distributions with very complicated patterns of singularities - the price to pay is that it is memory-hungry. It is therefore aimed at a small number of integration dimensions (<10). It should be combined with other methods for higher ...

  19. General-Purpose Heat Source development: Safety Verification Test Program. Bullet/fragment test series

    Energy Technology Data Exchange (ETDEWEB)

    George, T.G.; Tate, R.E.; Axler, K.M.

    1985-05-01

    The radioisotope thermoelectric generator (RTG) that will provide power for space missions contains 18 General-Purpose Heat Source (GPHS) modules. Each module contains four /sup 238/PuO/sub 2/-fueled clads and generates 250 W/sub (t)/. Because a launch-pad or post-launch explosion is always possible, we need to determine the ability of GPHS fueled clads within a module to survive fragment impact. The bullet/fragment test series, part of the Safety Verification Test Plan, was designed to provide information on clad response to impact by a compact, high-energy, aluminum-alloy fragment and to establish a threshold value of fragment energy required to breach the iridium cladding. Test results show that a velocity of 555 m/s (1820 ft/s) with an 18-g bullet is at or near the threshold value of fragment velocity that will cause a clad breach. Results also show that an exothermic Ir/Al reaction occurs if aluminum and hot iridium are in contact, a contact that is possible and most damaging to the clad within a narrow velocity range. The observed reactions between the iridium and the aluminum were studied in the laboratory and are reported in the Appendix.

  20. An FFT Performance Model for Optimizing General-Purpose Processor Architecture

    Institute of Scientific and Technical Information of China (English)

    Ling Li; Yun-Ji Chen; Dao-Fu Liu; Cheng Qian; Wei-Wu Hu

    2011-01-01

    General-purpose processor (GPP) is an important platform for fast Fourier transform (FFT),due to its flexibility,reliability and practicality.FFT is a representative application intensive in both computation and memory access,optimizing the FFT performance of a GPP also benefits the performances of many other applications.To facilitate the analysis of FFT,this paper proposes a theoretical model of the FFT processing.The model gives out a tight lower bound of the runtime of FFT on a GPP,and guides the architecture optimization for GPP as well.Based on the model,two theorems on optimization of architecture parameters are deduced,which refer to the lower bounds of register number and memory bandwidth.Experimental results on different processor architectures (including Intel Core i7 and Godson-3B) validate the performance model.The above investigations were adopted in the development of Godson-3B,which is an industrial GPP.The optimization techniques deduced from our performance model improve the FFT performance by about 40%,while incurring only 0.8% additional area cost.Consequently,Godson-3B solves the 1024-point single-precision complex FFT in 0.368 μs with about 40 Watt power consumption,and has the highest performance-per-watt in complex FFT among processors as far as we know.This work could benefit optimization of other GPPs as well.

  1. Practical Implementation of Prestack Kirchhoff Time Migration on a General Purpose Graphics Processing Unit

    Directory of Open Access Journals (Sweden)

    Liu Guofeng

    2016-08-01

    Full Text Available In this study, we present a practical implementation of prestack Kirchhoff time migration (PSTM on a general purpose graphic processing unit. First, we consider the three main optimizations of the PSTM GPU code, i.e., designing a configuration based on a reasonable execution, using the texture memory for velocity interpolation, and the application of an intrinsic function in device code. This approach can achieve a speedup of nearly 45 times on a NVIDIA GTX 680 GPU compared with CPU code when a larger imaging space is used, where the PSTM output is a common reflection point that is gathered as I[nx][ny][nh][nt] in matrix format. However, this method requires more memory space so the limited imaging space cannot fully exploit the GPU sources. To overcome this problem, we designed a PSTM scheme with multi-GPUs for imaging different seismic data on different GPUs using an offset value. This process can achieve the peak speedup of GPU PSTM code and it greatly increases the efficiency of the calculations, but without changing the imaging result.

  2. Practical Implementation of Prestack Kirchhoff Time Migration on a General Purpose Graphics Processing Unit

    Science.gov (United States)

    Liu, Guofeng; Li, Chun

    2016-08-01

    In this study, we present a practical implementation of prestack Kirchhoff time migration (PSTM) on a general purpose graphic processing unit. First, we consider the three main optimizations of the PSTM GPU code, i.e., designing a configuration based on a reasonable execution, using the texture memory for velocity interpolation, and the application of an intrinsic function in device code. This approach can achieve a speedup of nearly 45 times on a NVIDIA GTX 680 GPU compared with CPU code when a larger imaging space is used, where the PSTM output is a common reflection point that is gathered as I[ nx][ ny][ nh][ nt] in matrix format. However, this method requires more memory space so the limited imaging space cannot fully exploit the GPU sources. To overcome this problem, we designed a PSTM scheme with multi-GPUs for imaging different seismic data on different GPUs using an offset value. This process can achieve the peak speedup of GPU PSTM code and it greatly increases the efficiency of the calculations, but without changing the imaging result.

  3. Computing OpenSURF on OpenCL and General Purpose GPU

    Directory of Open Access Journals (Sweden)

    Wanglong Yan

    2013-10-01

    Full Text Available Speeded-Up Robust Feature (SURF algorithm is widely used for image feature detecting and matching in computer vision area. Open Computing Language (OpenCL is a framework for writing programs that execute across heterogeneous platforms consisting of CPUs, GPUs, and other processors. This paper introduces how to implement an open-sourced SURF program, namely OpenSURF, on general purpose GPU by OpenCL, and discusses the optimizations in terms of the thread architectures and memory models in detail. Our final OpenCL implementation of OpenSURF is on average 37% and 64% faster than the OpenCV SURF v2.4.5 CUDA implementation on NVidia's GTX660 and GTX460SE GPUs, repectively. Our OpenCL program achieved real-time performance (>25 Frames Per Second for almost all the input images with different sizes from 320*240 to 1024*768 on NVidia's GTX660 GPU, NVidia's GTX460SE GPU and AMD's Radeon HD 6850 GPU. Our OpenCL approach on NVidia's GTX660 GPU is more than 22.8 times faster than its original CPU version on Intel's Dual-Core E5400 2.7G on average.

  4. Computing OpenSURF on OpenCL and General Purpose GPU

    Directory of Open Access Journals (Sweden)

    Wanglong Yan

    2013-10-01

    Full Text Available Speeded-Up Robust Feature (SURF algorithm is widely used for image feature detecting and matching in computer vision area. Open Computing Language (OpenCL is a framework for writing programs that execute across heterogeneous platforms consisting of CPUs, GPUs, and other processors. This paper introduces how to implement an open-sourced SURF program, namely OpenSURF, on general purpose GPU by OpenCL, and discusses the optimizations in terms of the thread architectures and memory models in detail. Our final OpenCL implementation of OpenSURF is on average 37% and 64% faster than the OpenCV SURF v2.4.5 CUDA implementation on NVidia’s GTX660 and GTX460SE GPUs, repectively. Our OpenCL program achieved real-time performance (>25 Frames Per Second for almost all the input images with different sizes from 320*240 to 1024*768 on NVidia’s GTX660 GPU, NVidia’s GTX460SE GPU and AMD’s Radeon HD 6850 GPU. Our OpenCL approach on NVidia’s GTX660 GPU is more than 22.8 times faster than its original CPU version on Intel’s Dual-Core E5400 2.7G on average.

  5. Strong scaling of general-purpose molecular dynamics simulations on GPUs

    CERN Document Server

    Glaser, Jens; Anderson, Joshua A; Lui, Pak; Spiga, Filippo; Millan, Jaime A; Morse, David C; Glotzer, Sharon C

    2014-01-01

    We describe a highly optimized implementation of MPI domain decomposition in a GPU-enabled, general-purpose molecular dynamics code, HOOMD-blue (Anderson and Glotzer, arXiv:1308.5587). Our approach is inspired by a traditional CPU-based code, LAMMPS (Plimpton, J. Comp. Phys. 117, 1995), but is implemented within a code that was designed for execution on GPUs from the start (Anderson et al., J. Comp. Phys. 227, 2008). The software supports short-ranged pair force and bond force fields and achieves optimal GPU performance using an autotuning algorithm. We are able to demonstrate equivalent or superior scaling on up to 3,375 GPUs in Lennard-Jones and dissipative particle dynamics (DPD) simulations of up to 108 million particles. GPUDirect RDMA capabilities in recent GPU generations provide better performance in full double precision calculations. For a representative polymer physics application, HOOMD-blue 1.0 provides an effective GPU vs. CPU node speed-up of 12.5x.

  6. The Impact of General Strike on Government Healthcare Delivery in Kerala State in India

    Directory of Open Access Journals (Sweden)

    Aasems Jacob

    2016-01-01

    Full Text Available General strike (also known as hartal is used as a mode of protest by organizations and political parties in India. It is generally thought that hartals negatively impact the healthcare delivery in a society. We used the Right to Information Act to obtain data from government health centers in Kerala state in India for four hartal days (H-day and two control days (A-day and B-day for each H-day, from sixteen health centers including 6 Community Health Center (CHC, 6 Secondary Health Center (SHC, and 4 Tertiary Health Center (THC. Data on emergency room visits was available for six HCs. 15 HCs had a statistically significant decrease in the number of outpatient visits on H-day. There was no difference in the number of outpatient visits between the two control days (A and B in 15 HCs, suggesting the lack of a posthartal surge in visits. Median decrease in outpatient visits in CHCs, SHCs, and THCs was 50.4%, 59.5%, and 47.4%, respectively. Hartal did not impact the number of emergency room visits in 6 out of 7 health centers assessed. Our study identified a significant harmful impact on government healthcare delivery due to hartals in Kerala. These findings have major public health implications.

  7. Factors that influence delivery of tobacco cessation support in general dental practice: a narrative review.

    Science.gov (United States)

    Lala, Rizwana; Csikar, Julia; Douglas, Gail; Muarry, Jenni

    2017-12-01

    To review the literature reporting factors that are associated with the delivery of lifestyle support in general dental practice. A systematic review of the quantitative observational studies describing activities to promote the general health of adults in primary care general dental practice. Behavior change included tobacco cessation, alcohol reduction, diet, weight management, and physical activity. Tooth brushing and oral hygiene behaviors were excluded as the focus of this review was on the common risk factors that affect general health as well as oral health. Six cross sectional studies met the inclusion criteria. Five studies only reported activities to support tobacco cessation. As well as tobacco cessation one study also reported activities related to alcohol usage, physical activity, and Body Mass Index. Perceptions of time availability consistently correlated with activities and beliefs about tobacco cessation, alongside the smoking status of the dental professional. Dentists who perceive having more available time were more likely to discuss smoking with patients, prescribe smoking cessation treatments and direct patients toward (signpost to) lifestyle support services. Dental professionals who smoke were less likely to give smoking cessation advice and counselling than nonsmokers. Finally, the data showed that professional support may be relevant. Professionals who work in solo practices or those who felt a lack of support from the wider professional team (peer support) were more likely to report barriers to delivering lifestyle support. Organizational changes in dental practices to encourage more team working and professional time for lifestyle support may influence delivery. Dental professionals who are smokers may require training to develop their beliefs about the effectiveness of smoking cessation interventions. © 2016 American Association of Public Health Dentistry.

  8. A General-Purpose Optimization Engine for Multi-Disciplinary Design Applications

    Science.gov (United States)

    Patnaik, Surya N.; Hopkins, Dale A.; Berke, Laszlo

    1996-01-01

    A general purpose optimization tool for multidisciplinary applications, which in the literature is known as COMETBOARDS, is being developed at NASA Lewis Research Center. The modular organization of COMETBOARDS includes several analyzers and state-of-the-art optimization algorithms along with their cascading strategy. The code structure allows quick integration of new analyzers and optimizers. The COMETBOARDS code reads input information from a number of data files, formulates a design as a set of multidisciplinary nonlinear programming problems, and then solves the resulting problems. COMETBOARDS can be used to solve a large problem which can be defined through multiple disciplines, each of which can be further broken down into several subproblems. Alternatively, a small portion of a large problem can be optimized in an effort to improve an existing system. Some of the other unique features of COMETBOARDS include design variable formulation, constraint formulation, subproblem coupling strategy, global scaling technique, analysis approximation, use of either sequential or parallel computational modes, and so forth. The special features and unique strengths of COMETBOARDS assist convergence and reduce the amount of CPU time used to solve the difficult optimization problems of aerospace industries. COMETBOARDS has been successfully used to solve a number of problems, including structural design of space station components, design of nozzle components of an air-breathing engine, configuration design of subsonic and supersonic aircraft, mixed flow turbofan engines, wave rotor topped engines, and so forth. This paper introduces the COMETBOARDS design tool and its versatility, which is illustrated by citing examples from structures, aircraft design, and air-breathing propulsion engine design.

  9. A General-purpose Framework for Parallel Processing of Large-scale LiDAR Data

    Science.gov (United States)

    Li, Z.; Hodgson, M.; Li, W.

    2016-12-01

    Light detection and ranging (LiDAR) technologies have proven efficiency to quickly obtain very detailed Earth surface data for a large spatial extent. Such data is important for scientific discoveries such as Earth and ecological sciences and natural disasters and environmental applications. However, handling LiDAR data poses grand geoprocessing challenges due to data intensity and computational intensity. Previous studies received notable success on parallel processing of LiDAR data to these challenges. However, these studies either relied on high performance computers and specialized hardware (GPUs) or focused mostly on finding customized solutions for some specific algorithms. We developed a general-purpose scalable framework coupled with sophisticated data decomposition and parallelization strategy to efficiently handle big LiDAR data. Specifically, 1) a tile-based spatial index is proposed to manage big LiDAR data in the scalable and fault-tolerable Hadoop distributed file system, 2) two spatial decomposition techniques are developed to enable efficient parallelization of different types of LiDAR processing tasks, and 3) by coupling existing LiDAR processing tools with Hadoop, this framework is able to conduct a variety of LiDAR data processing tasks in parallel in a highly scalable distributed computing environment. The performance and scalability of the framework is evaluated with a series of experiments conducted on a real LiDAR dataset using a proof-of-concept prototype system. The results show that the proposed framework 1) is able to handle massive LiDAR data more efficiently than standalone tools; and 2) provides almost linear scalability in terms of either increased workload (data volume) or increased computing nodes with both spatial decomposition strategies. We believe that the proposed framework provides valuable references on developing a collaborative cyberinfrastructure for processing big earth science data in a highly scalable environment.

  10. General-Purpose Heat Source Development: Safety Test Program. Postimpact evaluation, Design Iteration Test 3

    Energy Technology Data Exchange (ETDEWEB)

    Schonfeld, F.W.; George, T.G.

    1984-07-01

    The General-Purpose Heat Source(GPHS) provides power for space missions by transmitting the heat of /sup 238/PuO/sub 2/ decay to thermoelectric elements. Because of the inevitable return of certain aborted missions, the heat source must be designed and constructed to survive both re-entry and Earth impact. The Design Iteration Test (DIT) series is part of an ongoing test program. In the third test (DIT-3), a full GPHS module was impacted at 58 m/s and 930/sup 0/C. The module impacted the target at an angle of 30/sup 0/ to the pole of the large faces. The four capsules used in DIT-3 survived impact with minimal deformation; no internal cracks other than in the regions indicated by Savannah River Plant (SRP) preimpact nondestructive testing were observed in any of the capsules. The 30/sup 0/ impact orientation used in DIT-3 was considerably less severe than the flat-on impact utilized in DIT-1 and DIT-2. The four capsules used in DIT-1 survived, while two of the capsules used in DIT-2 breached; a small quantity (approx. = 50 ..mu..g) of /sup 238/PuO/sub 2/ was released from the capsules breached in the DIT-2 impact. All of the capsules used in DIT-1 and DIT-2 were severely deformed and contained large internal cracks. Postimpact analyses of the DIT-3 test components are described, with emphasis on weld structure and the behavior of defects identified by SRP nondestructive testing.

  11. Apple-CORE: Microgrids of SVP cores: flexible, general-purpose, fine-grained hardware concurrency management

    NARCIS (Netherlands)

    Poss, R.; Lankamp, M.; Yang, Q.; Fu, J.; van Tol, M.W.; Jesshope, C.; Nair, S.

    2012-01-01

    To harness the potential of CMPs for scalable, energy-efficient performance in general-purpose computers, the Apple-CORE project has co-designed a general machine model and concurrency control interface with dedicated hardware support for concurrency control across multiple cores. Its SVP interface

  12. Optimization of GATE and PHITS Monte Carlo code parameters for uniform scanning proton beam based on simulation with FLUKA general-purpose code

    Energy Technology Data Exchange (ETDEWEB)

    Kurosu, Keita [Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Takashina, Masaaki; Koizumi, Masahiko [Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States); Moskvin, Vadim P., E-mail: vadim.p.moskvin@gmail.com [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States)

    2014-10-01

    Although three general-purpose Monte Carlo (MC) simulation tools: Geant4, FLUKA and PHITS have been used extensively, differences in calculation results have been reported. The major causes are the implementation of the physical model, preset value of the ionization potential or definition of the maximum step size. In order to achieve artifact free MC simulation, an optimized parameters list for each simulation system is required. Several authors have already proposed the optimized lists, but those studies were performed with a simple system such as only a water phantom. Since particle beams have a transport, interaction and electromagnetic processes during beam delivery, establishment of an optimized parameters-list for whole beam delivery system is therefore of major importance. The purpose of this study was to determine the optimized parameters list for GATE and PHITS using proton treatment nozzle computational model. The simulation was performed with the broad scanning proton beam. The influences of the customizing parameters on the percentage depth dose (PDD) profile and the proton range were investigated by comparison with the result of FLUKA, and then the optimal parameters were determined. The PDD profile and the proton range obtained from our optimized parameters list showed different characteristics from the results obtained with simple system. This led to the conclusion that the physical model, particle transport mechanics and different geometry-based descriptions need accurate customization in planning computational experiments for artifact-free MC simulation.

  13. Coated Particles Fuel Compact-General Purpose Heat Source for Advanced Radioisotope Power Systems

    Science.gov (United States)

    El-Genk, Mohamed S.; Tournier, Jean-Michel

    2003-01-01

    Coated Particles Fuel Compacts (CPFC) have recently been shown to offer performance advantage for use in Radioisotope Heater Units (RHUs) and design flexibility for integrating at high thermal efficiency with Stirling Engine converters, currently being considered for 100 We. Advanced Radioisotope Power Systems (ARPS). The particles in the compact consist of 238PuO2 fuel kernels with 5-μm thick PyC inner coating and a strong ZrC outer coating, whose thickness depends on the maximum fuel temperature during reentry, the fuel kernel diameter, and the fraction of helium gas released from the kernels and fully contained by the ZrC coating. In addition to containing the helium generated by radioactive decay of 238Pu for up to 10 years before launch and 10-15 years mission lifetime, the kernels are intentionally sized (>= 300 μm in diameter) to prevent any adverse radiological effects on reentry. This paper investigates the advantage of replacing the four iridium-clad 238PuO2 fuel pellets, the two floating graphite membranes, and the two graphite impact shells in current State-Of-The-Art (SOA) General Purpose Heat Source (GPHS) with CPFC. The total mass, thermal power, and specific power of the CPFC-GPHS are calculated as functions of the helium release fraction from the fuel kernels and maximum fuel temperature during reentry from 1500 K to 2400 K. For the same total mass and volume as SOA GPHS, the generated thermal power by single-size particles CPFC-GPHS is 260 W at Beginning-Of-Mission (BOM), versus 231 W for the GPHS. For an additional 10% increase in total mass, the CPFC-GPHS could generate 340 W BOM; 48% higher than SOA GPHS. The corresponding specific thermal power is 214 W/kg, versus 160 W/kg for SOA GPHS; a 34% increase. Therefore, for the same thermal power, the CPFC-GPHS is lighter than SOA GPHS, while it uses the same amount of 238PuO2 fuel and same aeroshell. For the same helium release fraction and fuel temperature, binary-size particles CPFC-GPHS could

  14. Root Effect Haemoglobins in Fish May Greatly Enhance General Oxygen Delivery Relative to Other Vertebrates.

    Directory of Open Access Journals (Sweden)

    Jodie L Rummer

    Full Text Available The teleost fishes represent over half of all extant vertebrates; they occupy nearly every body of water and in doing so, occupy a diverse array of environmental conditions. We propose that their success is related to a unique oxygen (O2 transport system involving their extremely pH-sensitive haemoglobin (Hb. A reduction in pH reduces both Hb-O2 affinity (Bohr effect and carrying capacity (Root effect. This, combined with a large arterial-venous pH change (ΔpHa-v relative to other vertebrates, may greatly enhance tissue oxygen delivery in teleosts (e.g., rainbow trout during stress, beyond that in mammals (e.g., human. We generated oxygen equilibrium curves (OECs at five different CO2 tensions for rainbow trout and determined that, when Hb-O2 saturation is 50% or greater, the change in oxygen partial pressure (ΔPO2 associated with ΔpHa-v can exceed that of the mammalian Bohr effect by at least 3-fold, but as much as 21-fold. Using known ΔpHa-v and assuming a constant arterial-venous PO2 difference (Pa-vO2, Root effect Hbs can enhance O2 release to the tissues by 73.5% in trout; whereas, the Bohr effect alone is responsible for enhancing O2 release by only 1.3% in humans. Disequilibrium states are likely operational in teleosts in vivo, and therefore the ΔpHa-v, and thus enhancement of O2 delivery, could be even larger. Modeling with known Pa-vO2 in fish during exercise and hypoxia indicates that O2 release from the Hb and therefore potentially tissue O2 delivery may double during exercise and triple during some levels of hypoxia. These characteristics may be central to performance of athletic fish species such as salmonids, but may indicate that general tissue oxygen delivery may have been the incipient function of Root effect Hbs in fish, a trait strongly associated with the adaptive radiation of teleosts.

  15. Parallelized computation for computer simulation of electrocardiograms using personal computers with multi-core CPU and general-purpose GPU.

    Science.gov (United States)

    Shen, Wenfeng; Wei, Daming; Xu, Weimin; Zhu, Xin; Yuan, Shizhong

    2010-10-01

    Biological computations like electrocardiological modelling and simulation usually require high-performance computing environments. This paper introduces an implementation of parallel computation for computer simulation of electrocardiograms (ECGs) in a personal computer environment with an Intel CPU of Core (TM) 2 Quad Q6600 and a GPU of Geforce 8800GT, with software support by OpenMP and CUDA. It was tested in three parallelization device setups: (a) a four-core CPU without a general-purpose GPU, (b) a general-purpose GPU plus 1 core of CPU, and (c) a four-core CPU plus a general-purpose GPU. To effectively take advantage of a multi-core CPU and a general-purpose GPU, an algorithm based on load-prediction dynamic scheduling was developed and applied to setting (c). In the simulation with 1600 time steps, the speedup of the parallel computation as compared to the serial computation was 3.9 in setting (a), 16.8 in setting (b), and 20.0 in setting (c). This study demonstrates that a current PC with a multi-core CPU and a general-purpose GPU provides a good environment for parallel computations in biological modelling and simulation studies. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  16. Factors Affecting Preservice Teachers' Computer Use for General Purposes: Implications for Computer Training Courses

    Science.gov (United States)

    Zogheib, Salah

    2014-01-01

    As the majority of educational research has focused on preservice teachers' computer use for "educational purposes," the question remains: Do preservice teachers use computer technology for daily life activities and encounters? And do preservice teachers' personality traits and motivational beliefs related to computer training provided…

  17. Factors Affecting Preservice Teachers' Computer Use for General Purposes: Implications for Computer Training Courses

    Science.gov (United States)

    Zogheib, Salah

    2014-01-01

    As the majority of educational research has focused on preservice teachers' computer use for "educational purposes," the question remains: Do preservice teachers use computer technology for daily life activities and encounters? And do preservice teachers' personality traits and motivational beliefs related to computer training provided…

  18. Recall of general and medical vocabulary and text structure knowledge: An experimental study of English for Medical Purposes

    Directory of Open Access Journals (Sweden)

    Zarein-Dolab S

    2008-07-01

    Full Text Available Background and purpose: A 3-unit course is dedicated to general language in medical universities and the vocabulary and text structure of the courses have usually no relation to medical language. We examine whether teaching general language will be as effective as medical language as assessed through recall of general and medical vocabulary and text structure knowledge. Methods: an experimental study was designed, in that, the third year students who had participated in the 3-unit general language classes in the first year of their General Practitioner (GP program were selected and sat for a 60 MCQ tests. The 60 MCQ tests consisted of 30 questions of general language, 25 vocabulary and 5 comprehension questions and also 30 questions of medical language, 25 technical and semi-technical vocabulary and 5 comprehension questions. In all, 145 medical students attended the exam which took 40 minutes to accomplish. Results: The results of the study indicated that memory retention was significantly lower in general language than medical language. The technical and semi-technical vocabulary items were significantly better recalled and the medical text was significantly better understood by the participants. Conclusion: A 3-unit course in general language may be a futile effort since the students will not be exposed to the same vocabulary and text structure knowledge in later years of their GP program. It is recommended that the focus of all the university English courses be on the medical language. Key words: Medical Vocabulary, English For Specific Purposes, ESP

  19. Generalized subcutaneous emphysema caused by injection of air into the penis for autoerotic purposes.

    Science.gov (United States)

    Ural, Y; Muthen, N; Engelmann, U; Wille, S

    2013-01-01

    The injection of air or water into the scrotum has been described only a few times so far in the literature. Injection of air into the penis and its consequences has not been described at all. Here, we present the case of a young man who, acting on his previously suppressed sexual fantasies, injected air into his penis and caused generalized subcutaneous emphysema.

  20. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Science.gov (United States)

    2010-07-01

    ... central premise underlying affirmative action is that, absent discrimination, over time a contractor's workforce, generally, will reflect the gender, racial and ethnic profile of the labor pools from which the... progress toward achieving the workforce that would be expected in the absence of discrimination. (2)...

  1. Matching the Purpose of the General Education Curriculum with the Reality of Its Implementation

    Science.gov (United States)

    Cottrell, Lesley; Cottrell, Scott; Wheatly, Michele; Jungblut, Bernadette; Dooley, Elizabeth A.; DiBartolomeo, Lisa

    2015-01-01

    This essay examines the current general education curriculum (gec) structure at a large institution where the gec program has been remodeled often to meet student needs. Assessment of this structure has been limited. Faculty and adviser perceptions of the gec's role in the larger curriculum, strengths, areas for improvement, and impact on student…

  2. Accuracy of Surface Plate Measurements - General Purpose Software for Flatness Measurement

    NARCIS (Netherlands)

    Meijer, J.; Heuvelman, C.J.

    1990-01-01

    Flatness departures of surface plates are generally obtained from straightness measurements of lines on the surface. A computer program has been developed for on-line measurement and evaluation, based on the simultaneous coupling of measurements in all grid points. Statistical methods are used to de

  3. The Dynamics of a General Purpose Technology in a Research and Assimilation Model

    NARCIS (Netherlands)

    Nahuis, R.

    1998-01-01

    Where is the productivity growth from the IT revolution? Why did the skill premium rise sharply in the early eighties? Were these phenomena related? This paper examines these questions in a general equilibrium model of growth. Technological progress in firms is driven by research aimed at improving

  4. Integration of the Density Gradient Model into a General Purpose Device Simulator

    Directory of Open Access Journals (Sweden)

    Andreas Wettstein

    2002-01-01

    Full Text Available A generalized Density Gradient model has been implemented into the device simulator Dessis [DESSIS 7.0 reference manual (2001. ISE Integrated Systems Engineering AG, Balgriststrasse 102, CH-8008 Zürich].We describe the multidimensional discretization scheme used and discuss our modifications to the standard Density Gradient model. The evaluation of the model shows good agreement to results obtained by the Schro¨dinger equation.

  5. Risk of Autism Associated with General Anesthesia during Cesarean Delivery: A Population-Based Birth-Cohort Analysis

    Science.gov (United States)

    Chien, Li-Nien; Lin, Hsiu-Chen; Shao, Yu-Hsuan Joni; Chiou, Shu-Ti; Chiou, Hung-Yi

    2015-01-01

    The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the…

  6. BLASTbus electronics: general-purpose readout and control for balloon-borne experiments

    CERN Document Server

    Benton, S J; Amiri, M; Angilè, F E; Bock, J J; Bond, J R; Bryan, S A; Chiang, H C; Contaldi, C R; Crill, B P; Devlin, M J; Dober, B; Doré, O P; Dowell, C D; Farhang, M; Filippini, J P; Fissel, L M; Fraisse, A A; Fukui, Y; Galitzki, N; Gambrel, A E; Gandilo, N N; Golwala, S R; Gudmundsson, J E; Halpern, M; Hasselfield, M; Hilton, G C; Holmes, W A; Hristov, V V; Irwin, K D; Jones, W C; Kermish, Z D; Klein, J; Korotkov, A L; Kuo, C L; MacTavish, C J; Mason, P V; Matthews, T G; Megerian, K G; Moncelsi, L; Morford, T A; Mroczkowski, T K; Nagy, J M; Netterfield, C B; Novak, G; Nutter, D; O'Brient, R; Ogburn, R W; Pascale, E; Poidevin, F; Rahlin, A S; Reintsema, C D; Ruhl, J E; Runyan, M C; Savini, G; Scott, D; Shariff, J A; Soler, J D; Thomas, N E; Trangsrud, A; Truch, M D; Tucker, C E; Tucker, G S; Tucker, R S; Turner, A D; Ward-Thompson, D; Weber, A C; Wiebe, D V; Young, E Y

    2014-01-01

    We present the second generation BLASTbus electronics. The primary purposes of this system are detector readout, attitude control, and cryogenic housekeeping, for balloon-borne telescopes. Readout of neutron transmutation doped germanium (NTD-Ge) bolometers requires low noise and parallel acquisition of hundreds of analog signals. Controlling a telescope's attitude requires the capability to interface to a wide variety of sensors and motors, and to use them together in a fast, closed loop. To achieve these different goals, the BLASTbus system employs a flexible motherboard-daughterboard architecture. The programmable motherboard features a digital signal processor (DSP) and field-programmable gate array (FPGA), as well as slots for three daughterboards. The daughterboards provide the interface to the outside world, with versions for analog to digital conversion, and optoisolated digital input/output. With the versatility afforded by this design, the BLASTbus also finds uses in cryogenic, thermometry, and powe...

  7. GAFit: A general-purpose, user-friendly program for fitting potential energy surfaces

    Science.gov (United States)

    Rodríguez-Fernández, Roberto; Pereira, Francisco B.; Marques, Jorge M. C.; Martínez-Núñez, Emilio; Vázquez, Saulo A.

    2017-08-01

    We have developed a software package based on a genetic algorithm that fits an analytic function to a given set of data points. The code, called GAFit, was also interfaced with the CHARMM and MOPAC programs in order to facilitate force field parameterizations and fittings of specific reaction parameters (SRP) for semiempirical Hamiltonians. The present tool may be applied to a wide range of fitting problems, though it has been especially designed to significantly reduce the hard work involved in the development of potential energy surfaces for complex systems. For this purpose, it has been equipped with several programs to help the user in the preparation of the input files. We showcase the application of the computational tool to several chemical-relevant problems: force-field parameterization, with emphasis on nonbonded energy terms or intermolecular potentials, derivation of SRP for semiempirical Hamiltonians, and fittings of generic analytical functions.

  8. Developing the VirtualwindoW into a General Purpose Telepresence Interface

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, Robert Arthur; Anderson, Matthew Oley; Mckay, Mark D; Willis, Walter David

    1999-04-01

    An important need while using robots or remotely operated equipment is the ability for the operator or an observer to easily and accurately perceive the operating environment. A classic problem in providing a complete representation of a work area is sensory overload or excessive complexity in the human–machine interface. In addition, remote operations often benefit from depth perception capability while viewing or manipulating objects. Thus, there is an on going effort within the robotic field to develop simplified telepresence interfaces. The Department of Energy’s Idaho National Engineering and Environmental Laboratory (INEEL) has been researching methods to generalize a human-machine interface for telepresence applications. Initial telepresence research conducted at the INEEL developed and implemented a concept called the VirtualwindoW. This system minimized the complexity of remote stereo viewing controls and provided the operator the “feel” of viewing the environment, including depth perception, in a natural setting. The VirtualwindoW has shown that the human-machine interface can be simplified while increasing operator performance. This paper deals with the continuing research and development of the VirtualwindoW to provide a generalized, reconfigurable system that easily utilizes commercially available components. The original system has now been expanded to include support for zoom lenses, camera blocks, wireless links, and even vehicle control.

  9. Developing the VirtualwindoW into a General Purpose Telepresence Interface

    Energy Technology Data Exchange (ETDEWEB)

    McKay, M D; Anderson, M O; Kinoshita, R A; Willis, W D

    1999-04-01

    An important need while using robots or remotely operated equipment is the ability for the operator or an observer to easily and accurately perceive the operating environment. A classic problem in providing a complete representation of a work area is sensory overload or excessive complexity in the human-machine interface. In addition, remote operations often benefit from depth perception capability while viewing or manipulating objects. Thus, there is an on going effort within the robotic field to develop simplified telepresence interfaces. The Department of Energy's Idaho National Engineering and Environmental Laboratory (INEEL) has been researching methods to generalize a human-machine interface for telepresence applications. Initial telepresence research conducted at the INEEL developed and implemented a concept called the VirtualwindoW. This system minimized the complexity of remote stereo viewing controls and provided the operator the "feel" of viewing the environment, including depth perception, in a natural setting. The VirtualwindoW has shown that the human-machine interface can be simplified while increasing operator performance. This paper deals with the continuing research and development of the VirtualwindoW to provide a generalized, reconfigurable system that easily utilizes commercially available components. The original system has now been expanded to include support for zoom lenses, camera blocks, wireless links, and even vehicle control.

  10. An LHCb general-purpose acquisition board for beam and background monitoring at the LHC

    CERN Document Server

    Alessio, F; Guzik, Z

    2011-01-01

    In this paper we will present an LHCb custom-made acquisition board which was developed for a continuous beam and background monitoring during LHC operations at CERN. The paper describes both the conceptual design and its performance, and concludes with results from the first period of beam operations at the LHC. The main purpose of the acquisition board is to process signals from a pair of beam pickups to continuously monitor the intensity of each bunch, and to monitor the phase of the arrival time of each proton bunch with respect to the LHC bunch clock. The extreme versatility of the board also allowed the LHCb experiment to build a high-speed and high-sensitivity readout system for a fast background monitor based on a pair of plastic scintillators. The board has demonstrated very good performance and proved to be conceptually valid during the first months of operations at the LHC. Connected to the beam pickups, it provides the LHCb experiment with a real-time measurement of the total intensity of each bea...

  11. BLASTbus electronics: general-purpose readout and control for balloon-borne experiments

    Science.gov (United States)

    Benton, S. J.; Ade, P. A.; Amiri, M.; Angilè, F. E.; Bock, J. J.; Bond, J. R.; Bryan, S. A.; Chiang, H. C.; Contaldi, C. R.; Crill, B. P.; Devlin, M. J.; Dober, B.; Doré, O. P.; Farhang, M.; Filippini, J. P.; Fissel, L. M.; Fraisse, A. A.; Fukui, Y.; Galitzki, N.; Gambrel, A. E.; Gandilo, N. N.; Golwala, S. R.; Gudmundsson, J. E.; Halpern, M.; Hasselfield, M.; Hilton, G. C.; Holmes, W. A.; Hristov, V. V.; Irwin, K. D.; Jones, W. C.; Kermish, Z. D.; Klein, J.; Korotkov, A. L.; Kuo, C. L.; MacTavish, C. J.; Mason, P. V.; Matthews, T. G.; Megerian, K. G.; Moncelsi, L.; Morford, T. A.; Mroczkowski, T. K.; Nagy, J. M.; Netterfield, C. B.; Novak, G.; Nutter, D.; O'Brient, R.; Ogburn, R. W.; Pascale, E.; Poidevin, F.; Rahlin, A. S.; Reintsema, C. D.; Ruhl, J. E.; Runyan, M. C.; Savini, G.; Scott, D.; Shariff, J. A.; Soler, J. D.; Thomas, N. E.; Trangsrud, A.; Truch, M. D.; Tucker, C. E.; Tucker, G. S.; Tucker, R. S.; Turner, A. D.; Ward-Thompson, D.; Weber, A. C.; Wiebe, D. V.; Young, E. Y.

    2014-07-01

    We present the second generation BLASTbus electronics. The primary purposes of this system are detector readout, attitude control, and cryogenic housekeeping, for balloon-borne telescopes. Readout of neutron transmutation doped germanium (NTD-Ge) bolometers requires low noise and parallel acquisition of hundreds of analog signals. Controlling a telescope's attitude requires the capability to interface to a wide variety of sensors and motors, and to use them together in a fast, closed loop. To achieve these different goals, the BLASTbus system employs a flexible motherboard-daughterboard architecture. The programmable motherboard features a digital signal processor (DSP) and field-programmable gate array (FPGA), as well as slots for three daughterboards. The daughterboards provide the interface to the outside world, with versions for analog to digital conversion, and optoisolated digital input/output. With the versatility afforded by this design, the BLASTbus also finds uses in cryogenic, thermometry, and power systems. For accurate timing control to tie everything together, the system operates in a fully synchronous manner. BLASTbus electronics have been successfully deployed to the South Pole, and own on stratospheric balloons.

  12. FLUENT/BFC - A general purpose fluid flow modeling program for all flow speeds

    Science.gov (United States)

    Dvinsky, Arkady S.

    FLUENT/BFC is a fluid flow modeling program for a variety of applications. Current capabilities of the program include laminar and turbulent flows, subsonic and supersonic viscous flows, incompressible flows, time-dependent and stationary flows, isothermal flows and flows with heat transfer, Newtonian and power-law fluids. The modeling equations in the program have been written in coordinate system invariant form to accommodate the use of boundary-conforming, generally nonorthogonal coordinate systems. The boundary-conforming coordinate system can be generated using both an internal grid generator, which is an integral part of the code, and external application-specific grid generators. The internal grid generator is based on a solution of a system of elliptic partial differential equations and can produce grids for a wide variety of two- and three-dimensional geometries.

  13. Atomicrex—a general purpose tool for the construction of atomic interaction models

    Science.gov (United States)

    Stukowski, Alexander; Fransson, Erik; Mock, Markus; Erhart, Paul

    2017-07-01

    We introduce atomicrex, an open-source code for constructing interatomic potentials as well as more general types of atomic-scale models. Such effective models are required to simulate extended materials structures comprising many thousands of atoms or more, because electronic structure methods become computationally too expensive at this scale. atomicrex covers a wide range of interatomic potential types and fulfills many needs in atomistic model development. As inputs, it supports experimental property values as well as ab initio energies and forces, to which models can be fitted using various optimization algorithms. The open architecture of atomicrex allows it to be used in custom model development scenarios beyond classical interatomic potentials while thanks to its Python interface it can be readily integrated e.g., with electronic structure calculations or machine learning algorithms.

  14. Analog models of computations \\& Effective Church Turing Thesis: Efficient simulation of Turing machines by the General Purpose Analog Computer

    CERN Document Server

    Pouly, Amaury; Graça, Daniel S

    2012-01-01

    \\emph{Are analog models of computations more powerful than classical models of computations?} From a series of recent papers, it is now clear that many realistic analog models of computations are provably equivalent to classical digital models of computations from a \\emph{computability} point of view. Take, for example, the probably most realistic model of analog computation, the General Purpose Analog Computer (GPAC) model from Claude Shannon, a model for Differential Analyzers, which are analog machines used from 1930s to early 1960s to solve various problems. It is now known that functions computable by Turing machines are provably exactly those that are computable by GPAC. This paper is about next step: understanding if this equivalence also holds at the \\emph{complexity} level. In this paper we show that the realistic models of analog computation -- namely the General Purpose Analog Computer (GPAC) -- can simulate Turing machines in a computationally efficient manner. More concretely we show that, modulo...

  15. A comprehensive workflow for general-purpose neural modeling with highly configurable neuromorphic hardware systems.

    Science.gov (United States)

    Brüderle, Daniel; Petrovici, Mihai A; Vogginger, Bernhard; Ehrlich, Matthias; Pfeil, Thomas; Millner, Sebastian; Grübl, Andreas; Wendt, Karsten; Müller, Eric; Schwartz, Marc-Olivier; de Oliveira, Dan Husmann; Jeltsch, Sebastian; Fieres, Johannes; Schilling, Moritz; Müller, Paul; Breitwieser, Oliver; Petkov, Venelin; Muller, Lyle; Davison, Andrew P; Krishnamurthy, Pradeep; Kremkow, Jens; Lundqvist, Mikael; Muller, Eilif; Partzsch, Johannes; Scholze, Stefan; Zühl, Lukas; Mayr, Christian; Destexhe, Alain; Diesmann, Markus; Potjans, Tobias C; Lansner, Anders; Schüffny, René; Schemmel, Johannes; Meier, Karlheinz

    2011-05-01

    In this article, we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems. We describe in detail a device with 45 million programmable and dynamic synapses that is currently under development, and we sketch the conceptual challenges that arise from taking this platform into operation. More specifically, we aim at the establishment of this neuromorphic system as a flexible and neuroscientifically valuable modeling tool that can be used by non-hardware experts. We consider various functional aspects to be crucial for this purpose, and we introduce a consistent workflow with detailed descriptions of all involved modules that implement the suggested steps: The integration of the hardware interface into the simulator-independent model description language PyNN; a fully automated translation between the PyNN domain and appropriate hardware configurations; an executable specification of the future neuromorphic system that can be seamlessly integrated into this biology-to-hardware mapping process as a test bench for all software layers and possible hardware design modifications; an evaluation scheme that deploys models from a dedicated benchmark library, compares the results generated by virtual or prototype hardware devices with reference software simulations and analyzes the differences. The integration of these components into one hardware-software workflow provides an ecosystem for ongoing preparative studies that support the hardware design process and represents the basis for the maturity of the model-to-hardware mapping software. The functionality and flexibility of the latter is proven with a variety of experimental results.

  16. Quality of healthcare websites: A comparison of a general-purpose vs. domain-specific search engine.

    Science.gov (United States)

    Abraham, Joanna; Reddy, Madhu

    2007-10-11

    In a pilot study, we had five typical Internet users evaluate the quality of health websites returned by a general-purpose search engine (Google) and a healthcare-specific search engine (Healthfinder). The evaluators used a quality criteria developed by Mitretek/Health Information Technology Institute. Although both search engines provided high quality health websites, we found some important differences between the two types of search engines.

  17. HOOMD-blue, general-purpose many-body dynamics on the GPU

    Science.gov (United States)

    Anderson, Joshua; Keys, Aaron; Phillips, Carolyn; Dac Nguyen, Trung; Glotzer, Sharon

    2010-03-01

    We present HOOMD-blue, a new, open source code for performing molecular dynamics and related many-body dynamics simulations on graphics processing units (GPUs). All calculations are fully implemented on the GPU, enabling large performance speedups over traditional CPUs. On typical benchmarks, HOOMD-blue is about 60 times faster on a current generation GPU compared to running on a single CPU core. Next generation chips are due for release in early 2010 and are expected to nearly double performance. Efficient execution is achieved without any lack of generality and thus a wide variety of capabilities are present in the code, including standard bond, pair, angle, dihedral and improper potentials, along with the common NPT, NVE, NVT, and Brownian dynamics integration routines. The code is object-oriented, well documented, and easy to modify. We are constantly adding new features and looking for new developers to contribute to this fast maturing, open-source code [1]. In this talk, we present an overview of HOOMD-blue and give examples of its current and planned capabilities and speed over traditional CPU-based codes. [1] Find HOOMD-blue online at: http://codeblue.umich.edu/hoomd-blue/

  18. General Purpose Real-time Data Analysis and Visualization Software for Volcano Observatories

    Science.gov (United States)

    Cervelli, P. F.; Miklius, A.; Antolik, L.; Parker, T.; Cervelli, D.

    2011-12-01

    In 2002, the USGS developed the Valve software for management, visualization, and analysis of volcano monitoring data. In 2004, the USGS developed similar software, called Swarm, for the same purpose but specifically tailored for seismic waveform data. Since then, both of these programs have become ubiquitous at US volcano observatories, and in the case of Swarm, common at volcano observatories across the globe. Though innovative from the perspective of software design, neither program is methodologically novel. Indeed, the software can perform little more than elementary 2D graphing, along with basic geophysical analysis. So, why is the software successful? The answer is that both of these programs take data from the realm of discipline specialists and make them universally available to all observatory scientists. In short, the software creates additional value from existing data by leveraging the observatory's entire intellectual capacity. It enables rapid access to different data streams, and allows anyone to compare these data on a common time scale or map base. It frees discipline specialists from routine tasks like preparing graphics or compiling data tables, thereby making more time for interpretive efforts. It helps observatory scientists browse through data, and streamlines routine checks for unusual activity. It encourages a multi-parametric approach to volcano monitoring. And, by means of its own usefulness, it creates incentive to organize and capture data streams not yet available. Valve and Swarm are both written in Java, open-source, and freely available. Swarm is a stand-alone Java application. Valve is a system consisting of three parts: a web-based user interface, a graphing and analysis engine, and a data server. Both can be used non-interactively (e.g., via scripts) to generate graphs or to dump raw data. Swarm has a simple, built-in alarm capability. Several alarm algorithms have been built around Valve. Both programs remain under active

  19. TOUGH2: A general-purpose numerical simulator for multiphase nonisothermal flows

    Energy Technology Data Exchange (ETDEWEB)

    Pruess, K. [Lawrence Berkeley Lab., CA (United States)

    1991-06-01

    Numerical simulators for multiphase fluid and heat flows in permeable media have been under development at Lawrence Berkeley Laboratory for more than 10 yr. Real geofluids contain noncondensible gases and dissolved solids in addition to water, and the desire to model such `compositional` systems led to the development of a flexible multicomponent, multiphase simulation architecture known as MULKOM. The design of MULKOM was based on the recognition that the mass-and energy-balance equations for multiphase fluid and heat flows in multicomponent systems have the same mathematical form, regardless of the number and nature of fluid components and phases present. Application of MULKOM to different fluid mixtures, such as water and air, or water, oil, and gas, is possible by means of appropriate `equation-of-state` (EOS) modules, which provide all thermophysical and transport parameters of the fluid mixture and the permeable medium as a function of a suitable set of primary thermodynamic variables. Investigations of thermal and hydrologic effects from emplacement of heat-generating nuclear wastes into partially water-saturated formations prompted the development and release of a specialized version of MULKOM for nonisothermal flow of water and air, named TOUGH. TOUGH is an acronym for `transport of unsaturated groundwater and heat` and is also an allusion to the tuff formations at Yucca Mountain, Nevada. The TOUGH2 code is intended to supersede TOUGH. It offers all the capabilities of TOUGH and includes a considerably more general subset of MULKOM modules with added capabilities. The paper briefly describes the simulation methodology and user features.

  20. Delivery presentations

    Science.gov (United States)

    ... passage will take place depends on how your baby is positioned during delivery. The best position for the baby to be ... possible, but labor will generally take longer. After delivery, the baby's face or brow will be swollen and may ...

  1. Assessment of general public perceptions toward traditional medicines used for aphrodisiac purpose in state of Penang, Malaysia.

    Science.gov (United States)

    Hassali, Mohamed Azmi; Saleem, Fahad; Shafie, Asrul Akmal; Al-Qazaz, Harith Khalid; Farooqui, Maryam; Aljadhey, Hisham; Atif, Muhammad; Masood, Imran

    2012-11-01

    The study aims to evaluate general public perceptions regarding the use of Traditional and Complementary Medicines (TCM) for aphrodisiac purposes. A questionnaire based, cross-sectional study was undertaken. Respondents were selected in the state of Penang, Malaysia. A total of 392 respondents were included in the study. Descriptive statistics were used for data analysis. Chi Square/Fischer Exact tests were used where appropriate. Out of 392 respondents, 150 (38.26%) reported using specific Traditional medicines for aphrodisiac purposes. Most respondents (46.94%) agreed that aphrodisiac medicines were easily available t. Moreover, 40.31% of the respondents reported that traditional aphrodisiac medicines were cheaper than modern (prescription) medicines. This study highlights limited public knowledge regarding the use of traditional aphrodisiac medicine. Healthcare professionals should be aware of informal TCM usage when prescribing allopathic medicines. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. A general-purpose framework to simulate musculoskeletal system of human body: using a motion tracking approach.

    Science.gov (United States)

    Ehsani, Hossein; Rostami, Mostafa; Gudarzi, Mohammad

    2016-02-01

    Computation of muscle force patterns that produce specified movements of muscle-actuated dynamic models is an important and challenging problem. This problem is an undetermined one, and then a proper optimization is required to calculate muscle forces. The purpose of this paper is to develop a general model for calculating all muscle activation and force patterns in an arbitrary human body movement. For this aim, the equations of a multibody system forward dynamics, which is considered for skeletal system of the human body model, is derived using Lagrange-Euler formulation. Next, muscle contraction dynamics is added to this model and forward dynamics of an arbitrary musculoskeletal system is obtained. For optimization purpose, the obtained model is used in computed muscle control algorithm, and a closed-loop system for tracking desired motions is derived. Finally, a popular sport exercise, biceps curl, is simulated by using this algorithm and the validity of the obtained results is evaluated via EMG signals.

  3. Is Generalized Maternal Optimism or Pessimism During Pregnancy Associated with Unplanned Cesarean Section Deliveries in China?

    Science.gov (United States)

    Moyer, Cheryl A.; Elsayed, Yasmin; Zhu, YuChun; Wei, Yumei; Engmann, Cyril M.; Yang, Huixia

    2010-01-01

    This research examines whether maternal optimism/pessimism is associated with unplanned Cesarean section deliveries in China. If so, does the association remain after controlling for clinical factors associated with C-sections? A sample of 227 mostly primiparous women in the third trimester of pregnancy was surveyed in a large tertiary care hospital in Beijing, China. Post-delivery data were collected from medical records. In bivariate analysis, both optimism and pessimism were related to unplanned c-section. However, when optimism and pessimism were entered into a regression model together, optimism was no longer statistically significant. Pessimism remained significant, even when adjusting for clinical factors such as previous abortion, previous miscarriage, pregnancy complications, infant gestational age, infant birthweight, labor duration, birth complications, and self-rated difficulty of the pregnancy. This research suggests that maternal mindset during pregnancy has a role in mode of delivery. However, more research is needed to elucidate potential causal pathways and test potential interventions. PMID:21490743

  4. Is generalized maternal optimism or pessimism during pregnancy associated with unplanned cesarean section deliveries in China?

    Science.gov (United States)

    Moyer, Cheryl A; Elsayed, Yasmin; Zhu, Yuchun; Wei, Yumei; Engmann, Cyril M; Yang, Huixia

    2010-01-01

    This research examines whether maternal optimism/pessimism is associated with unplanned Cesarean section deliveries in China. If so, does the association remain after controlling for clinical factors associated with C-sections? A sample of 227 mostly primiparous women in the third trimester of pregnancy was surveyed in a large tertiary care hospital in Beijing, China. Post-delivery data were collected from medical records. In bivariate analysis, both optimism and pessimism were related to unplanned c-section. However, when optimism and pessimism were entered into a regression model together, optimism was no longer statistically significant. Pessimism remained significant, even when adjusting for clinical factors such as previous abortion, previous miscarriage, pregnancy complications, infant gestational age, infant birthweight, labor duration, birth complications, and self-rated difficulty of the pregnancy. This research suggests that maternal mindset during pregnancy has a role in mode of delivery. However, more research is needed to elucidate potential causal pathways and test potential interventions.

  5. Corrosion science general-purpose data model and interface (I): Meanings and issues of design and implementation

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A brand new design of integrated corrosion information system is introduced to meet the constantly increasing demands of material corrosion information. Two concepts, "general-purpose corrosion data model" and "public corrosion data ex-changing interface", are suggested to integrate a wide variety of corrosion data sources based on detailed analysis on characteristics of each source in order to promote the information sharing and data mining. The architecture of integrated corrosion information environment is blueprinted. The insight analysis is focused on 1) architecture of the system; 2) data flow and information sharing; 3) roles of system players and their interactions; 4) approaches to data integration. Several key issues are addressed in detail including coverage of data model, data source integration and mitigation, and data granularity from system performance and model acceptance points of view. At the end, the design and implementation ap-proach of general corrosion data model is presented based on cutting edge IT techniques.

  6. Corrosion science general-purpose data model and interface (I): Meanings and issues of design and implementation

    Institute of Scientific and Technical Information of China (English)

    TANG ZiLong

    2008-01-01

    A brand new design of integrated corrosion information system is introduced to meet the constantly increasing demands of material corrosion information. Two concepts, "general-purpose corrosion data model" and "public corrosion data ex- changing interface", are suggested to integrate a wide variety of corrosion data sources based on detailed analysis on characteristics of each source in order to promote the information sharing and data mining. The architecture of integrated corrosion information environment is blueprinted. The insight analysis is focused on 1) architecture of the system; 2) data flow and information sharing; 3) roles of system players and their interactions; 4) approaches to data integration. Several key issues are addressed in detail including coverage of data model, data source integration and mitigation, and data granularity from system performance and model acceptance points of view. At the end, the design and implementation ap- proach of general corrosion data model is presented based on cutting edge IT techniques.

  7. Speech-Language Pathologist and General Educator Collaboration: A Model for Tier 2 Service Delivery

    Science.gov (United States)

    Watson, Gina D.; Bellon-Harn, Monica L.

    2014-01-01

    Tier 2 supplemental instruction within a response to intervention framework provides a unique opportunity for developing partnerships between speech-language pathologists and classroom teachers. Speech-language pathologists may participate in Tier 2 instruction via a consultative or collaborative service delivery model depending on district needs.…

  8. General purpose parallel programing using new generation graphic processors: CPU vs GPU comparative analysis and opportunities research

    Directory of Open Access Journals (Sweden)

    Donatas Krušna

    2013-03-01

    Full Text Available OpenCL, a modern parallel heterogeneous system programming language, enables problems to be partitioned and executed on modern CPU and GPU hardware, this increases performance of such applications considerably. Since GPU's are optimized for floating point and vector operations and specialize in them, they outperform general purpose CPU's in this field greatly. This language greatly simplifies the creation of applications for such heterogeneous system since it's cross-platform, vendor independent and is embeddable , hence letting it be used in any other general purpose programming language via libraries. There is more and more tools being developed that are aimed at low level programmers and scientists or engineers alike, that are developing applications or libraries for CPU’s and GPU’s of today as well as other heterogeneous platforms. The tendency today is to increase the number of cores or CPU‘s in hopes of increasing performance, however the increasing difficulty of parallelizing applications for such systems and the even increasing overhead of communication and synchronization are limiting the potential performance. This means that there is a point at which increasing cores or CPU‘s will no longer increase applications performance, and even can diminish performance. Even though parallel programming and GPU‘s with stream computing capabilities have decreased the need for communication and synchronization (since only the final result needs to be committed to memory, however this still is a weak link in developing such applications.

  9. Multi­-Threaded Algorithms for General purpose Graphics Processor Units in the ATLAS High Level Trigger

    CERN Document Server

    Conde Mui\\~no, Patricia; The ATLAS collaboration

    2016-01-01

    General purpose Graphics Processor Units (GPGPU) are being evaluated for possible future inclusion in an upgraded ATLAS High Level Trigger farm. We have developed a demonstrator including GPGPU implementations of Inner Detector and Muon tracking and Calorimeter clustering within the ATLAS software framework. ATLAS is a general purpose particle physics experiment located on the LHC collider at CERN. The ATLAS Trigger system consists of two levels, with level 1 implemented in hardware and the High Level Trigger implemented in software running on a farm of commodity CPU. The High Level Trigger reduces the trigger rate from the 100 kHz level 1 acceptance rate to 1 kHz for recording, requiring an average per­-event processing time of ~250 ms for this task. The selection in the high level trigger is based on reconstructing tracks in the Inner Detector and Muon Spectrometer and clusters of energy deposited in the Calorimeter. Performing this reconstruction within the available farm resources presents a significant ...

  10. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments.

    Science.gov (United States)

    Lee, Kangwon; Silva, Eduardo A; Mooney, David J

    2011-02-06

    The identification and production of recombinant morphogens and growth factors that play key roles in tissue regeneration have generated much enthusiasm and numerous clinical trials, but the results of many of these trials have been largely disappointing. Interestingly, the trials that have shown benefit all contain a common denominator, the presence of a material carrier, suggesting strongly that spatio-temporal control over the location and bioactivity of factors after introduction into the body is crucial to achieve tangible therapeutic effect. Sophisticated materials systems that regulate the biological presentation of growth factors represent an attractive new generation of therapeutic agents for the treatment of a wide variety of diseases. This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.

  11. Is Generalized Maternal Optimism or Pessimism During Pregnancy Associated with Unplanned Cesarean Section Deliveries in China?

    Directory of Open Access Journals (Sweden)

    Cheryl A. Moyer

    2010-01-01

    Full Text Available This research examines whether maternal optimism/pessimism is associated with unplanned Cesarean section deliveries in China. If so, does the association remain after controlling for clinical factors associated with C-sections? A sample of 227 mostly primiparous women in the third trimester of pregnancy was surveyed in a large tertiary care hospital in Beijing, China. Post-delivery data were collected from medical records. In bivariate analysis, both optimism and pessimism were related to unplanned c-section. However, when optimism and pessimism were entered into a regression model together, optimism was no longer statistically significant. Pessimism remained significant, even when adjusting for clinical factors such as previous abortion, previous miscarriage, pregnancy complications, infant gestational age, infant birthweight, labor duration, birth complications, and self-rated difficulty of the pregnancy. This research suggests that maternal mindset during pregnancy has a role in mode of delivery. However, more research is needed to elucidate potential causal pathways and test potential interventions.

  12. Is What I Need What I Want? Reconceptualising College Students' Needs in English Courses for General and Specific/Academic Purposes

    Science.gov (United States)

    Liu, Jin-Yu; Chang, Yu-Jung; Yang, Fang-Ying; Sun, Yu-Chih

    2011-01-01

    The purpose of the study is to explore English as a foreign language (EFL) college students' needs in English for General Purposes (EGP) and English for Specific/Academic Purposes (ESP/EAP) courses in terms of their perceptions of three subcategories of needs--necessities, wants, and lacks--and reasons for students' course enrollment. A…

  13. Duplication of complete dentures using general-purpose handheld optical scanner and 3-dimensional printer: Introduction and clinical considerations.

    Science.gov (United States)

    Kurahashi, Kosuke; Matsuda, Takashi; Goto, Takaharu; Ishida, Yuichi; Ito, Teruaki; Ichikawa, Tetsuo

    2017-01-01

    To introduce a new clinical procedure for fabricating duplicates of complete dentures by bite pressure impression using digital technology, and to discuss its clinical significance. The denture is placed on a rotary table and the 3-dimensional form of the denture is digitized using a general-purpose handheld optical scanner. The duplicate denture is made of polylactic acid by a 3-dimensional printer using the 3-dimensional data. This procedure has the advantages of wasting less material, employing less human power, decreasing treatment time at the chair side, lowering the rates of contamination, and being readily fabricated at the time of the treatment visit. Copyright © 2016 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

  14. Feasibility study for the measurement of Bc meson mass and lifetime with the general purpose detector at the LHC

    Institute of Scientific and Technical Information of China (English)

    MENG Xiang-Wei

    2008-01-01

    In this paper a feasibility study of the Bc meson to measure its mass and lifetime is described with the general purpose detector at the LHC.The study solely concentrated on the J/Ψπ+,J/Ψ→μ+μ- decay channel of the Bc and it was concluded that about 120 events can be selected in the first fb-1 of data.With this data sample,the mass resolution was estimated to be 2.0(stat.) MeV/c2 while the cr resolution was found to be 13.1(stat.) μm,I.e.the lifetime resolution to be 0.044(stat.) ps.

  15. Evaluation of Aqueous and Powder Processing Techniques for Production of Pu-238-Fueled General Purpose Heat Sources

    Energy Technology Data Exchange (ETDEWEB)

    2008-06-01

    This report evaluates alternative processes that could be used to produce Pu-238 fueled General Purpose Heat Sources (GPHS) for radioisotope thermoelectric generators (RTG). Fabricating GPHSs with the current process has remained essentially unchanged since its development in the 1970s. Meanwhile, 30 years of technological advancements have been made in the fields of chemistry, manufacturing, ceramics, and control systems. At the Department of Energy’s request, alternate manufacturing methods were compared to current methods to determine if alternative fabrication processes could reduce the hazards, especially the production of respirable fines, while producing an equivalent GPHS product. An expert committee performed the evaluation with input from four national laboratories experienced in Pu-238 handling.

  16. EARTHQUAKE RESPONSE ANALYSIS OF STEEL PORTAL FRAMES BY PSEUDODYNAMIC SIMULATION TECHNIQUE USING A GENERAL-PURPOSE FINITE ELEMENT ANALYSIS PROGRAM

    Science.gov (United States)

    Miki, Toshihiro; Mizusawa, Tomisaku; Yamada, Osamu; Toda, Tomoki

    This paper studies the earthquake response of steel portal frames when the shear collapse occurs at the centre of the beam. The pseudodynamic simulation technique for the earthquake response analysis of the frames is developed in correspondence to the pseudodynamic substructure testing method. For the thin-walled box element under shear force in the middle of beam, the numerical process is utilized by a general-purpose finite element analysis program. The numerical results show the shear collapse behaviour in stiffened box beams and corresponding restoring force - displacement relationship of frames. The advantages of shear collapse of beams for the use in frames during earthquakes are discussed from the point of view of the hysteretic energy dissipated by the column base.

  17. Description of a4-channel FPGA-controlled ADC-based DAQ system for general purpose PMT signals

    Energy Technology Data Exchange (ETDEWEB)

    Conde, Ruben; Salazar, Humberto; Martinez, Oscar [Facultad de Ciencias FIsico Matematicas, BUAP, Puebla (Mexico); Villasenor, L, E-mail: rbn_cnd@hotmail.com [Instituto de Fisica y Matematicas, Universidad Michoacana San Nicolas de Hidalgo, Morelia (Mexico)

    2011-04-01

    We describe a general purpose data acquisition system for PMT signals. Hardware-wise it consists of a 4-channel ADC daughter board, an FPGA mother board, a GPS receiver and an atmospheric pressure sensor and a temperature sensor. The four ADC channels simultaneously sample PMT input signals with a sampling rate of 100MS/s. We have evaluated the noise of our system obtaining less than -48.6dB. This DAQ system includes a firmware suitable for pulse processing in cosmic rays applications. In particular, we describe in detail the way in which this system can be used during the commissioning and early operation phases of the High Altitude Water Cherenkov Observatory (HAWC) currently under construction at Sierra Negra in Mexico.

  18. RUMD: A general purpose molecular dynamics package optimized to utilize GPU hardware down to a few thousand particles

    CERN Document Server

    Bailey, Nicholas P; Hansen, Jesper Schmidt; Veldhorst, Arno A; Bøhling, Lasse; Lemarchand, Claire A; Olsen, Andreas E; Bacher, Andreas K; Larsen, Heine; Dyre, Jeppe C; Schrøder, Thomas B

    2015-01-01

    RUMD is a general purpose, high-performance molecular dynamics (MD) simulation package running on graphical processing units (GPU's). RUMD addresses the challenge of utilizing the many-core nature of modern GPU hardware when simulating small to medium system sizes (roughly from a few thousand up to hundred thousand particles). It has a performance that is comparable to other GPU-MD codes at large system sizes and substantially better at smaller sizes.RUMD is open-source and consists of a library written in C++ and the CUDA extension to C, an easy-to-use Python interface, and a set of tools for set-up and post-simulation data analysis. The paper describes RUMD's main features, optimizations and performance benchmarks.

  19. General-purpose heat source: Research and development program, radioisotope thermoelectric generator/thin fragment impact test

    Energy Technology Data Exchange (ETDEWEB)

    Reimus, M.A.H.; Hinckley, J.E.

    1996-11-01

    The general-purpose heat source provides power for space missions by transmitting the heat of {sup 238}Pu decay to an array of thermoelectric elements in a radioisotope thermoelectric generator (RTG). Because the potential for a launch abort or return from orbit exists for any space mission, the heat source response to credible accident scenarios is being evaluated. This test was designed to provide information on the response of a loaded RTG to impact by a fragment similar to the type of fragment produced by breakup of the spacecraft propulsion module system. The results of this test indicated that impact by a thin aluminum fragment traveling at 306 m/s may result in significant damage to the converter housing, failure of one fueled clad, and release of a small quantity of fuel.

  20. Nanoparticle delivery systems, general approaches, and their implementation in multiple myeloma.

    Science.gov (United States)

    de la Puente, Pilar; Azab, Abdel Kareem

    2017-02-16

    Multiple myeloma (MM) is a hematological malignancy that remains incurable, with relapse rates >90%. The main limiting factor for the effective use of chemotherapies in MM is the serious side effects caused by these drugs. The emphasis in cancer treatment has shifted from cytotoxic, non-specific chemotherapies to molecularly targeted and rationally designed therapies showing greater efficacy and fewer side effects. Traditional chemotherapy has shown several disadvantages such as lack of targeting capabilities, systemic toxicity, and side effects; low therapeutic index, as well as most anticancer drugs, has poor water solubility. Nanoparticle delivery systems (NPs) are capable of targeting large doses of chemotherapies into the target area while sparing healthy tissues, overcoming the limitations of traditional chemotherapy. Here, we review the current state of the art in nanoparticle-based strategies designed to treat MM. Many nanoparticle delivery systems have been studied for myeloma using non-targeted NPs (liposomes, polymeric NPs, and inorganic NPs), triggered NPs, as well as targeted NPs (VLA-4, ABC drug transporters, bone microenvironment targeting). The results in preclinical and clinical studies are promising; however, there remains much to be learned in the emerging field of nanomedicine in myeloma.

  1. Scleroderma and pulmonary hypertension complicating two pregnancies: use of neuraxial anesthesia, general anesthesia, epoprostenol and a multidisciplinary approach for cesarean delivery.

    Science.gov (United States)

    Moaveni, D; Cohn, J; Brodt, J; Hoctor, K; Ranasinghe, J

    2015-11-01

    Literature regarding the anesthetic care of patients with scleroderma during labor and delivery is limited to remote case reports. No recent publications provide information on the anesthetic management of patients with coexisting pulmonary hypertension. This report describes the anesthetic and multidisciplinary management of two pregnant patients with concomitant scleroderma and pulmonary hypertension undergoing cesarean delivery; one with neuraxial anesthesia and one with general anesthesia. Considerations for neuraxial and general anesthesia in patients with concurrent scleroderma and pulmonary hypertension are discussed.

  2. SU-E-T-254: Optimization of GATE and PHITS Monte Carlo Code Parameters for Uniform Scanning Proton Beam Based On Simulation with FLUKA General-Purpose Code

    Energy Technology Data Exchange (ETDEWEB)

    Kurosu, K [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan); Department of Medical Physics ' Engineering, Osaka University Graduate School of Medicine, Osaka (Japan); Takashina, M; Koizumi, M [Department of Medical Physics ' Engineering, Osaka University Graduate School of Medicine, Osaka (Japan); Das, I; Moskvin, V [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN (United States)

    2014-06-01

    Purpose: Monte Carlo codes are becoming important tools for proton beam dosimetry. However, the relationships between the customizing parameters and percentage depth dose (PDD) of GATE and PHITS codes have not been reported which are studied for PDD and proton range compared to the FLUKA code and the experimental data. Methods: The beam delivery system of the Indiana University Health Proton Therapy Center was modeled for the uniform scanning beam in FLUKA and transferred identically into GATE and PHITS. This computational model was built from the blue print and validated with the commissioning data. Three parameters evaluated are the maximum step size, cut off energy and physical and transport model. The dependence of the PDDs on the customizing parameters was compared with the published results of previous studies. Results: The optimal parameters for the simulation of the whole beam delivery system were defined by referring to the calculation results obtained with each parameter. Although the PDDs from FLUKA and the experimental data show a good agreement, those of GATE and PHITS obtained with our optimal parameters show a minor discrepancy. The measured proton range R90 was 269.37 mm, compared to the calculated range of 269.63 mm, 268.96 mm, and 270.85 mm with FLUKA, GATE and PHITS, respectively. Conclusion: We evaluated the dependence of the results for PDDs obtained with GATE and PHITS Monte Carlo generalpurpose codes on the customizing parameters by using the whole computational model of the treatment nozzle. The optimal parameters for the simulation were then defined by referring to the calculation results. The physical model, particle transport mechanics and the different geometrybased descriptions need accurate customization in three simulation codes to agree with experimental data for artifact-free Monte Carlo simulation. This study was supported by Grants-in Aid for Cancer Research (H22-3rd Term Cancer Control-General-043) from the Ministry of Health

  3. Time-Cost Scheduler for Technological and Economic Challenges Related to Customized Cores and General Purpose Processors

    Directory of Open Access Journals (Sweden)

    Munesh Singh Chauhan

    2014-01-01

    Full Text Available With the renewed interest in the customization of embedded processors for applications specific needs, it becomes imperative to understand its viability both economically and technologically thus avoiding pitfalls. Customization and scalability are two terms which are often used synonymously to denote add/ subtract of additional functional units or increase/ decrease of ports in memory register banks in processors. The advantage that comes out of customization is in the improved performance, reduced silicon area and power efficiency. With the option of parameterizing the inclusion/ exclusion of functional units the hardware can be made leaner and thus more energy efficient. Removal of redundant units results in shortening of critical path in circuits. Though the above advantages look significant but customization carries its own pitfalls which often are intractable. Firstly, it carries an immense overhead if performed in General Purpose Processors (GPUs. Changes in the hardware architecture results in code mismatch and thus necessitates ISA (Instruction Set Architecture extensions or at times complete overhaul. Besides, users are often reluctant to adapt to the changes in ISA as it involves additional training. The final death knell may come from the limited commercial use of customized processor thus resulting in economic losses due to under-utilization of production units. Hence a new insight is needed that caters to the utilization of present technological advancements in processor customization but at the same time avoiding adverse economic fallout that comes from blindly forcing customization everywhere. A graded and selective use of customization in consonance with market and user needs is suggested. Therefore, predicting the development course of micro processors in general and embedded processors in particular will benefit businesses to correctly focus on the performance and efficiency of systems that use these processors

  4. General-purpose computer networks and resource sharing in ERDA. Volume 3. Remote resource-sharing experience and findings

    Energy Technology Data Exchange (ETDEWEB)

    1977-07-15

    The investigation focused on heterogeneous networks in which a variety of dissimilar computers and operating systems were interconnected nationwide. Homogeneous networks, such as MFE net and SACNET, were not considered since they could not be used for general purpose resource sharing. Issues of privacy and security are of concern in any network activity. However, consideration of privacy and security of sensitive data arise to a much lesser degree in unclassified scientific research than in areas involving personal or proprietary information. Therefore, the existing mechanisms at individual sites for protecting sensitive data were relied on, and no new protection mechanisms to prevent infringement of privacy and security were attempted. Further development of ERDA networking will need to incorporate additional mechanisms to prevent infringement of privacy. The investigation itself furnishes an excellent example of computational resource sharing through a heterogeneous network. More than twenty persons, representing seven ERDA computing sites, made extensive use of both ERDA and non-ERDA computers in coordinating, compiling, and formatting the data which constitute the bulk of this report. Volume 3 analyzes the benefits and barriers encountered in actual resource sharing experience, and provides case histories of typical applications.

  5. MetaboLights--an open-access general-purpose repository for metabolomics studies and associated meta-data.

    Science.gov (United States)

    Haug, Kenneth; Salek, Reza M; Conesa, Pablo; Hastings, Janna; de Matos, Paula; Rijnbeek, Mark; Mahendraker, Tejasvi; Williams, Mark; Neumann, Steffen; Rocca-Serra, Philippe; Maguire, Eamonn; González-Beltrán, Alejandra; Sansone, Susanna-Assunta; Griffin, Julian L; Steinbeck, Christoph

    2013-01-01

    MetaboLights (http://www.ebi.ac.uk/metabolights) is the first general-purpose, open-access repository for metabolomics studies, their raw experimental data and associated metadata, maintained by one of the major open-access data providers in molecular biology. Metabolomic profiling is an important tool for research into biological functioning and into the systemic perturbations caused by diseases, diet and the environment. The effectiveness of such methods depends on the availability of public open data across a broad range of experimental methods and conditions. The MetaboLights repository, powered by the open source ISA framework, is cross-species and cross-technique. It will cover metabolite structures and their reference spectra as well as their biological roles, locations, concentrations and raw data from metabolic experiments. Studies automatically receive a stable unique accession number that can be used as a publication reference (e.g. MTBLS1). At present, the repository includes 15 submitted studies, encompassing 93 protocols for 714 assays, and span over 8 different species including human, Caenorhabditis elegans, Mus musculus and Arabidopsis thaliana. Eight hundred twenty-seven of the metabolites identified in these studies have been mapped to ChEBI. These studies cover a variety of techniques, including NMR spectroscopy and mass spectrometry.

  6. MetaboLights—an open-access general-purpose repository for metabolomics studies and associated meta-data

    Science.gov (United States)

    Haug, Kenneth; Salek, Reza M.; Conesa, Pablo; Hastings, Janna; de Matos, Paula; Rijnbeek, Mark; Mahendraker, Tejasvi; Williams, Mark; Neumann, Steffen; Rocca-Serra, Philippe; Maguire, Eamonn; González-Beltrán, Alejandra; Sansone, Susanna-Assunta; Griffin, Julian L.; Steinbeck, Christoph

    2013-01-01

    MetaboLights (http://www.ebi.ac.uk/metabolights) is the first general-purpose, open-access repository for metabolomics studies, their raw experimental data and associated metadata, maintained by one of the major open-access data providers in molecular biology. Metabolomic profiling is an important tool for research into biological functioning and into the systemic perturbations caused by diseases, diet and the environment. The effectiveness of such methods depends on the availability of public open data across a broad range of experimental methods and conditions. The MetaboLights repository, powered by the open source ISA framework, is cross-species and cross-technique. It will cover metabolite structures and their reference spectra as well as their biological roles, locations, concentrations and raw data from metabolic experiments. Studies automatically receive a stable unique accession number that can be used as a publication reference (e.g. MTBLS1). At present, the repository includes 15 submitted studies, encompassing 93 protocols for 714 assays, and span over 8 different species including human, Caenorhabditis elegans, Mus musculus and Arabidopsis thaliana. Eight hundred twenty-seven of the metabolites identified in these studies have been mapped to ChEBI. These studies cover a variety of techniques, including NMR spectroscopy and mass spectrometry. PMID:23109552

  7. The EB Factory Project I. A Fast, Neural Net Based, General Purpose Light Curve Classifier Optimized for Eclipsing Binaries

    CERN Document Server

    Paegert, M; Burger, D M

    2014-01-01

    We describe a new neural-net based light curve classifier and provide it with documentation as a ready-to-use tool for the community. While optimized for identification and classification of eclipsing binary stars, the classifier is general purpose, and has been developed for speed in the context of upcoming massive surveys such as LSST. A challenge for classifiers in the context of neural-net training and massive data sets is to minimize the number of parameters required to describe each light curve. We show that a simple and fast geometric representation that encodes the overall light curve shape, together with a chi-square parameter to capture higher-order morphology information results in efficient yet robust light curve classification, especially for eclipsing binaries. Testing the classifier on the ASAS light curve database, we achieve a retrieval rate of 98\\% and a false-positive rate of 2\\% for eclipsing binaries. We achieve similarly high retrieval rates for most other periodic variable-star classes,...

  8. Deposition, characterization, and in vivo performance of parylene coating on general-purpose silicone for examining potential biocompatible surface modifications

    Energy Technology Data Exchange (ETDEWEB)

    Chou, Chia-Man [Division of Pediatric Surgery, Department of Surgery, Taichung Veterans General Hospital, 160, Sec. 3, Taichung Port Rd., Taichung 40705, Taiwan, ROC (China); Department of Medicine, National Yang-Ming University, 155, Sec. 2, Linong Street, Taipei 11221, Taiwan, ROC (China); Shiao, Chiao-Ju [Department of Materials Science and Engineering, Feng Chia University, 100, Wen-Hwa Rd., Taichung 40724, Taiwan, ROC (China); Chung, Chi-Jen, E-mail: cjchung@seed.net.tw [Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, 666 Buzih Rd., Beitun District, Taichung 40601, Taiwan, ROC (China); He, Ju-Liang [Department of Materials Science and Engineering, Feng Chia University, 100, Wen-Hwa Rd., Taichung 40724, Taiwan, ROC (China)

    2013-12-31

    In this study, a thorough investigation of parylene coatings was conducted, as follows: microstructure (i.e., X-ray diffractometer (XRD) and cold field emission scanning electron microscope (FESEM)), mechanical property (i.e., pencil hardness and cross-cut adhesion test), surface property (i.e., water contact angle measurement, IR, and X-ray photoelectron spectroscopy (XPS)), and biocompatibility tests (i.e., fibroblast cell culture, platelet adhesion, and animal studies). The results revealed that parylene, a crystalline and brittle coating, exhibited satisfactory film adhesion and relative hydrophobicity, thereby contributing to its effective barrier properties. Fibroblast cell culturing on the parylene-deposited specimen demonstrated improved cell proliferation and equivalent to or superior blood compatibility than that of the medical-grade silicone (currently used clinically). In the animal study, parylene coatings exhibited similar subcutaneous inflammatory reactions compared with the medical-grade silicone. Both in vitro and in vivo tests demonstrated the satisfactory biocompatibility of parylene coatings. - Highlights: • A complete investigation to identify the characteristics of parylene coatings on general-purpose silicones. • Microstructures, surface properties and mechanical properties of parylene coatings were examined. • In vitro (Cell culture, platelet adhesion) tests and animal studies revealed satisfactory biocompatibility. • An alternative of medical-grade silicones is expected to be obtained.

  9. GPHS-RTG system explosion test direct course experiment 5000. [General Purpose Heat Source-Radioisotope Thermoelectric Generator

    Energy Technology Data Exchange (ETDEWEB)

    1984-03-01

    The General Purpose Heat Source-Radioisotope Thermoelectric Generator (GPHS-RTG) has been designed and is being built to provide electrical power for spacecrafts to be launched on the Space Shuttle. The objective of the RTG System Explosion Test was to expose a mock-up of the GPHS-RTG with a simulated heat source to the overpressure and impulse representative of a potential upper magnitude explosion of the Space Shuttle. The test was designed so that the heat source module would experience an overpressure at which the survival of the fuel element cladding would be expected to be marginal. Thus, the mock-up was placed where the predicted incident overpressure would be 1300 psi. The mock-up was mounted in an orientation representative of the launch configuration on the spacecraft to be used on the NASA Galileo Mission. The incident overpressure measured was in the range of 1400 to 2100 psi. The mock-up and simulated heat source were destroyed and only very small fragments were recovered. This damage is believed to have resulted from a combination of the overpressure and impact by very high velocity fragments from the ANFO sphere. Post-test analysis indicated that extreme working of the iridium clad material occurred, indicative of intensive impulsive loading on the metal.

  10. General-purpose computer networks and resource sharing in ERDA. Volume 3. Remote resource-sharing experience and findings

    Energy Technology Data Exchange (ETDEWEB)

    1977-07-15

    The investigation focused on heterogeneous networks in which a variety of dissimilar computers and operating systems were interconnected nationwide. Homogeneous networks, such as MFE net and SACNET, were not considered since they could not be used for general purpose resource sharing. Issues of privacy and security are of concern in any network activity. However, consideration of privacy and security of sensitive data arise to a much lesser degree in unclassified scientific research than in areas involving personal or proprietary information. Therefore, the existing mechanisms at individual sites for protecting sensitive data were relied on, and no new protection mechanisms to prevent infringement of privacy and security were attempted. Further development of ERDA networking will need to incorporate additional mechanisms to prevent infringement of privacy. The investigation itself furnishes an excellent example of computational resource sharing through a heterogeneous network. More than twenty persons, representing seven ERDA computing sites, made extensive use of both ERDA and non-ERDA computers in coordinating, compiling, and formatting the data which constitute the bulk of this report. Volume 3 analyzes the benefits and barriers encountered in actual resource sharing experience, and provides case histories of typical applications.

  11. Corrosion science general-purpose data model and interface (Ⅱ): OOD design and corrosion data markup language (CDML)

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    With object oriented design/analysis, a general purpose corrosion data model (GPCDM) and a corrosion data markup language (CDML) are created to meet the increasing demand of multi-source corrosion data integration and sharing. "Cor- rosion data island" is proposed to model the corrosion data of comprehensiveness and self-contained. The island of tree-liked structure contains six first-level child nodes to characterize every important aspect of the corrosion data. Each first-level node holds more child nodes recursively as data containers. The design of data structure inside the island is intended to decrease the learning curve and break the acceptance barrier of GPCDM and CDML. A detailed explanation about the role and meaning of the first-level nodes are presented with examples chosen carefully in order to review the design goals and requirements proposed in the previous paper. Then, CDML tag structure and CDML application programming interface (API) are introduced in logic order. At the end, the roles of GPCDM, CDML and its API in the multi-source corrosion data integration and information sharing are highlighted and projected.

  12. Corrosion science general-purpose data model and interface (Ⅱ): OOD design and corrosion data markup language (CDML)

    Institute of Scientific and Technical Information of China (English)

    TANG ZiLong

    2008-01-01

    With object oriented design/analysis, a general purpose corrosion data model (GPCDM) and a corrosion data markup language (CDML) are created to meet the increasing demand of multi-source corrosion data integration and sharing. "Cor-rosion data island" is proposed to model the corrosion data of comprehensiveness and self-contained. The island of tree-liked structure contains six first-level child nodes to characterize every important aspect of the corrosion data. Each first-level node holds more child nodes recursively as data containers. The design of data structure inside the island is intended to decrease the learning curve and break the acceptance barrier of GPCDM and CDML. A detailed explanation about the role and meaning of the first-level nodes are presented with examples chosen carefully in order to review the design goals and requirements proposed in the previous paper. Then, CDML tag structure and CDML application programming interface (API) are introduced in logic order. At the end, the roles of GPCDM, CDML and its API in the multi-source corrosion data integration and information sharing are highlighted and projected.

  13. Research and Development of the General-Purpose Computation on GPUs%GPGPU技术研究与发展

    Institute of Scientific and Technical Information of China (English)

    林一松; 唐玉华; 唐滔

    2011-01-01

    半导体工艺的发展使得芯片上集成的晶体管数目不断增加,图形处理器的存储和计算能力也越来越强大.目前,GPU的峰值运算能力已经远远超出主流的CPU,它在非图形计算领域,特别是高性能计算领域的潜力已经引起越来越多研究者的关注.本文介绍了GPU用于通用计算的原理以及目前学 术界和产业界关于GPGPU体系结构和编程模型方面的最新研究成果.%With the development of the semiconductor technology? The number of transistors integrated on a chip keeps increasing. Consequently, the computation and memory capacity of graphics processing units improve rapidly. So far, the floating-point computing capacity of GPUs has greatly exceeded that of CPUs, and the potential of GPUs in the non-graphic computing field, especially in high performance computing, has attracted more and more researchers' attention. This paper gives an introduction to the principles of the general purpose computation on GPUs and the latest research results about architecture and the programming model of GPGPU from both the research community and industry.

  14. Cafe Variome: general-purpose software for making genotype-phenotype data discoverable in restricted or open access contexts.

    Science.gov (United States)

    Lancaster, Owen; Beck, Tim; Atlan, David; Swertz, Morris; Thangavelu, Dhiwagaran; Veal, Colin; Dalgleish, Raymond; Brookes, Anthony J

    2015-10-01

    Biomedical data sharing is desirable, but problematic. Data "discovery" approaches-which establish the existence rather than the substance of data-precisely connect data owners with data seekers, and thereby promote data sharing. Cafe Variome (http://www.cafevariome.org) was therefore designed to provide a general-purpose, Web-based, data discovery tool that can be quickly installed by any genotype-phenotype data owner, or network of data owners, to make safe or sensitive content appropriately discoverable. Data fields or content of any type can be accommodated, from simple ID and label fields through to extensive genotype and phenotype details based on ontologies. The system provides a "shop window" in front of data, with main interfaces being a simple search box and a powerful "query-builder" that enable very elaborate queries to be formulated. After a successful search, counts of records are reported grouped by "openAccess" (data may be directly accessed), "linkedAccess" (a source link is provided), and "restrictedAccess" (facilitated data requests and subsequent provision of approved records). An administrator interface provides a wide range of options for system configuration, enabling highly customized single-site or federated networks to be established. Current uses include rare disease data discovery, patient matchmaking, and a Beacon Web service.

  15. In vivo dosimetry in intraoperative electron radiotherapy. microMOSFETs, radiochromic films and a general-purpose linac

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Tarjuelo, Juan; Marco-Blancas, Noelia de; Santos-Serra, Agustin; Quiros-Higueras, Juan David [Consorcio Hospitalario Provincial de Castellon, Servicio de Radiofisica y Proteccion Radiologica, Castellon de la Plana (Spain); Bouche-Babiloni, Ana; Morillo-Macias, Virginia; Ferrer-Albiach, Carlos [Consorcio Hospitalario Provincial de Castellon, Servicio de Oncologia Radioterapica, Castellon de la Plana (Spain)

    2014-11-15

    In vivo dosimetry is desirable for the verification, recording, and eventual correction of treatment in intraoperative electron radiotherapy (IOERT). Our aim is to share our experience of metal oxide semiconductor field-effect transistors (MOSFETs) and radiochromic films with patients undergoing IOERT using a general-purpose linac. We used MOSFETs inserted into sterile bronchus catheters and radiochromic films that were cut, digitized, and sterilized by means of gas plasma. In all, 59 measurements were taken from 27 patients involving 15 primary tumors (seven breast and eight non-breast tumors) and 12 relapses. Data were subjected to an outliers' analysis and classified according to their compatibility with the relevant doses. Associations were sought regarding the type of detector, breast and non-breast irradiation, and the radiation oncologist's assessment of the difficulty of detector placement. At the same time, 19 measurements were carried out at the tumor bed with both detectors. MOSFET measurements (D = 93.5 %, s{sub D} = 6.5 %) were not significantly shifted from film measurements (D = 96.0 %, s{sub D} = 5.5 %; p = 0.109), and no associations were found (p = 0.526, p = 0.295, and p = 0.501, respectively). As regards measurements performed at the tumor bed with both detectors, MOSFET measurements (D = 95.0 %, s{sub D} = 5.4 %) were not significantly shifted from film measurements (D = 96.4 %, s{sub D} = 5.0 %; p = 0.363). In vivo dosimetry can produce satisfactory results at every studied location with a general-purpose linac. Detector choice should depend on user factors, not on the detector performance itself. Surgical team collaboration is crucial to success. (orig.) [German] Die In-vivo-Dosimetrie ist wuenschenswert fuer die Ueberpruefung, Registrierung und die eventuelle Korrektur der Behandlungen in der IOERT (''Intraoperative Electron Radiation Therapy''). Unser Ziel ist die Veroeffentlichung unserer Erfahrungen beim

  16. The ESPAT tool: a general-purpose DSS shell for solving stochastic optimization problems in complex river-aquifer systems

    Science.gov (United States)

    Macian-Sorribes, Hector; Pulido-Velazquez, Manuel; Tilmant, Amaury

    2015-04-01

    Stochastic programming methods are better suited to deal with the inherent uncertainty of inflow time series in water resource management. However, one of the most important hurdles in their use in practical implementations is the lack of generalized Decision Support System (DSS) shells, usually based on a deterministic approach. The purpose of this contribution is to present a general-purpose DSS shell, named Explicit Stochastic Programming Advanced Tool (ESPAT), able to build and solve stochastic programming problems for most water resource systems. It implements a hydro-economic approach, optimizing the total system benefits as the sum of the benefits obtained by each user. It has been coded using GAMS, and implements a Microsoft Excel interface with a GAMS-Excel link that allows the user to introduce the required data and recover the results. Therefore, no GAMS skills are required to run the program. The tool is divided into four modules according to its capabilities: 1) the ESPATR module, which performs stochastic optimization procedures in surface water systems using a Stochastic Dual Dynamic Programming (SDDP) approach; 2) the ESPAT_RA module, which optimizes coupled surface-groundwater systems using a modified SDDP approach; 3) the ESPAT_SDP module, capable of performing stochastic optimization procedures in small-size surface systems using a standard SDP approach; and 4) the ESPAT_DET module, which implements a deterministic programming procedure using non-linear programming, able to solve deterministic optimization problems in complex surface-groundwater river basins. The case study of the Mijares river basin (Spain) is used to illustrate the method. It consists in two reservoirs in series, one aquifer and four agricultural demand sites currently managed using historical (XIV century) rights, which give priority to the most traditional irrigation district over the XX century agricultural developments. Its size makes it possible to use either the SDP or

  17. Development and validation of a general-purpose ASIC chip for the control of switched reluctance machines

    Energy Technology Data Exchange (ETDEWEB)

    Chen Haijin [National ASIC System Engineering Research Center, Southeast University, Nanjing 210096 (China); Jiang-Su Provincial Key Lab of ASIC Design, Nantong University, Nantong 226019 (China)], E-mail: chen.hj@ntu.edu.cn; Lu Shengli; Shi Longxing [National ASIC System Engineering Research Center, Southeast University, Nanjing 210096 (China)

    2009-03-15

    A general-purpose application specific integrated circuit (ASIC) chip for the control of switched reluctance machines (SRMs) was designed and validated to fill the gap between the microcontroller capability and the controller requirements of high performance switched reluctance drive (SRD) systems. It can be used for the control of SRM running either in low speed or in high-speed, i.e., either in chopped current control (CCC) mode or in angular position control (APC) mode. Main functions of the chip include filtering and cycle calculation of rotor angular position signals, commutation logic according to rotor cycle and turn-on/turn-off angles ({theta}{sub on}/{theta}{sub off}), controllable pulse width modulation (PWM) waveforms generation, chopping control with adjustable delay time, and commutation control with adjustable delay time. All the control parameters of the chip are set online by the microcontroller through a serial peripheral interface (SPI). The chip has been designed with the standard cell based design methodology, and implemented in the central semiconductor manufacturing corporation (CSMC) 0.5 {mu}m complementary metal-oxide-semiconductor (CMOS) process technology. After a successful automatic test equipment (ATE) test using the Nextest's Maverick test system, the chip was further validated through an experimental three-phase 6/2-pole SRD system. Both the ATE test and experimental validation results show that the chip can meet the control requirements of high performance SRD systems, and simplify the controller construction. For a resolution of 0.36 deg. (electrical degree), the chip's maximum processable frequency of the rotor angular position signals is 10 kHz, which is 300,000 rev/min when a three-phase 6/2-pole SRM is concerned.

  18. Development and validation of a general-purpose ASIC chip for the control of switched reluctance machines

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hai-Jin [National ASIC System Engineering Research Center, Southeast University, Nanjing 210096 (China)]|[Jiang-Su Provincial Key Lab of ASIC Design, Nantong University, Nantong 226019 (China); Lu, Sheng-Li; Shi, Long-Xing [National ASIC System Engineering Research Center, Southeast University, Nanjing 210096 (China)

    2009-03-15

    A general-purpose application specific integrated circuit (ASIC) chip for the control of switched reluctance machines (SRMs) was designed and validated to fill the gap between the microcontroller capability and the controller requirements of high performance switched reluctance drive (SRD) systems. It can be used for the control of SRM running either in low speed or in high-speed, i.e., either in chopped current control (CCC) mode or in angular position control (APC) mode. Main functions of the chip include filtering and cycle calculation of rotor angular position signals, commutation logic according to rotor cycle and turn-on/turn-off angles ({theta}{sub on}/{theta}{sub off}), controllable pulse width modulation (PWM) waveforms generation, chopping control with adjustable delay time, and commutation control with adjustable delay time. All the control parameters of the chip are set online by the microcontroller through a serial peripheral interface (SPI). The chip has been designed with the standard cell based design methodology, and implemented in the central semiconductor manufacturing corporation (CSMC) 0.5 {mu}m complementary metal-oxide-semiconductor (CMOS) process technology. After a successful automatic test equipment (ATE) test using the Nextest's Maverick test system, the chip was further validated through an experimental three-phase 6/2-pole SRD system. Both the ATE test and experimental validation results show that the chip can meet the control requirements of high performance SRD systems, and simplify the controller construction. For a resolution of 0.36 (electrical degree), the chip's maximum processable frequency of the rotor angular position signals is 10 kHz, which is 300,000 rev/min when a three-phase 6/2-pole SRM is concerned. (author)

  19. A Comparison of General Education Co-Teaching versus Special Education Resource Service Delivery Models on Math Achievement of Students with Disabilities

    Science.gov (United States)

    Nash-Aurand, Tammy

    2013-01-01

    Recent legislation in education mandates that students with disabilities be given access to the general education curriculum in order to reach higher academic standards. To meet these requirements, co-teaching has become a popular service delivery model for instruction of students with disabilities within the general education setting. The purpose…

  20. Administración de la alimentación enteral en salas generales de internación Nutrition delivery in general wards

    Directory of Open Access Journals (Sweden)

    MV Bertona

    2009-12-01

    associated with more complications, increased duration of hospital stay, and greater associated costs. The objective of this study is to establish the rate of inadequate delivery of prescribed enteral feedings by nasogastric tube and the reasons for inadequate delivery in hospitalized patients. A descriptive observational cross-sectional prospective study was performed from July 2008 through February 2009. The study included 43 patients hospitalized at Argerich Hospital in the Clinical Medicine, General Surgery and Neurosurgery wards, who were receiving enteral nutrition by nasogastric tube as the only route of feeding. Overall delivery of enteral nutrition by nasogastric tube was found inadequate in 79.10% of cases (CI 95%: 64-90%. Nursing staffand patient-related causes were the most common reasons for discontinuing enteral feeding (35.85% and 30.19%, respectively. Patient-related causes included gastrointestinal intolerance and nasogastric tube removal. According to the results of this research, we conclude that the implementation of specific protocols should be promoted in every ward since they are a simple and effective approach and their use is clearly associated with an improvement in enteral nutrition delivery in hospitalized patients.

  1. Perioperative low-dose ketamine improves postoperative analgesia following Cesarean delivery with general anesthesia.

    Science.gov (United States)

    Haliloglu, Murat; Ozdemir, Mehtap; Uzture, Neslihan; Cenksoy, Pinar Ozcan; Bakan, Nurten

    2016-03-01

    In this study, the effect of perioperative uses of low dose ketamine on post-operative wound pain and analgesic consumption in patients undergoing elective Cesarean section was evaluated. In randomized, double blind clinical trial, 52 women with American Society of Anesthesiologists (ASA) class I-II identification undergoing elective Cesarean section in general anesthesia were enrolled. In the ketamine group (group K), a ketamine bolus of 0.5 mg kg(-1) IV was administered at the time of induction of general anesthesia. After induction, a ketamine infusion of 0.25 mg kg(-1) h(-1) was started and discontinued at the end of surgery. Patients allocated to the control group (group C) were given identical volumes of saline. The cumulative dose of morphine consumption after surgery was measured as the primary outcome of this study. Secondary outcomes were pain control assessed by numeric rating scale (NRS) and need for rescue analgesia and incidence of side effects. The mean 24-h morphine consumption was lower in group K (p = 0,001). At 15 min postoperatively, NRS values were lower in group K than group C (p = 0,001). There was no difference among groups regarding the need for supplemental analgesia (rescue diclofenac doses) (p > 0.05). Perioperative uses of low dose ketamine decreased post-operative opioid requirements, which was observed long after the normal expected duration of ketamine.

  2. Ultra-fast digital tomosynthesis reconstruction using general-purpose GPU programming for image-guided radiation therapy.

    Science.gov (United States)

    Park, Justin C; Park, Sung Ho; Kim, Jin Sung; Han, Youngyih; Cho, Min Kook; Kim, Ho Kyung; Liu, Zhaowei; Jiang, Steve B; Song, Bongyong; Song, William Y

    2011-08-01

    The purpose of this work is to demonstrate an ultra-fast reconstruction technique for digital tomosynthesis (DTS) imaging based on the algorithm proposed by Feldkamp, Davis, and Kress (FDK) using standard general-purpose graphics processing unit (GPGPU) programming interface. To this end, the FDK-based DTS algorithm was programmed "in-house" with C language with utilization of 1) GPU and 2) central processing unit (CPU) cards. The GPU card consisted of 480 processing cores (2 x 240 dual chip) with 1,242 MHz processing clock speed and 1,792 MB memory space. In terms of CPU hardware, we used 2.68 GHz clock speed, 12.0 GB DDR3 RAM, on a 64-bit OS. The performance of proposed algorithm was tested on twenty-five patient cases (5 lung, 5 liver, 10 prostate, and 5 head-and-neck) scanned either with a full-fan or half-fan mode on our cone-beam computed tomography (CBCT) system. For the full-fan scans, the projections from 157.5°-202.5° (45°-scan) were used to reconstruct coronal DTS slices, whereas for the half-fan scans, the projections from both 157.5°-202.5° and 337.5°-22.5° (2 x 45°-scan) were used to reconstruct larger FOV coronal DTS slices. For this study, we chose 45°-scan angle that contained ~80 projections for the full-fan and ~160 projections with 2 x 45°-scan angle for the half-fan mode, each with 1024 x 768 pixels with 32-bit precision. Absolute pixel value differences, profiles, and contrast-to-noise ratio (CNR) calculations were performed to compare and evaluate the images reconstructed using GPU- and CPU-based implementations. The time dependence on the reconstruction volume was also tested with (512 x 512) x 16, 32, 64, 128, and 256 slices. In the end, the GPU-based implementation achieved, at most, 1.3 and 2.5 seconds to complete full reconstruction of 512 x 512 x 256 volume, for the full-fan and half-fan modes, respectively. In turn, this meant that our implementation can process > 13 projections-per-second (pps) and > 18 pps for the full

  3. General Purpose Ground Forces: What Purpose?

    Science.gov (United States)

    1993-04-06

    PEACEKEEPING CONTINGENCY eSTRATEGIC RESERVE " ACTIVEARMY DIVlSIO S 1 Note a 1 5 Note b 2 Note c ! ~ESERVE ARMY _ S , EAVY]CADRE REGIS... designed to perform traditional domestic missions and those overseas humanitarian and peacekeeping assignments that carry litt].e risk of combat

  4. Effectiveness of using high-fidelity simulation to teach the management of general anesthesia for Cesarean delivery.

    Science.gov (United States)

    Balki, Mrinalini; Chakravarty, Subrata; Salman, Aliya; Wax, Randy S

    2014-10-01

    The objective of this study was to assess the influence of a teaching plan consisting of didactic teaching and repeated simulations on the performance of anesthesia residents in the management of general anesthesia (GA) for emergency Cesarean delivery (CD). Twenty-one postgraduate year 2 (PGY2) and 3 (PGY3) anesthesia residents from the University of Toronto were recruited in this prospective cohort study. All participants received didactic teaching in the management of GA for emergency CD, which was followed one week later by assessment of performance in the same scenario using a high-fidelity simulator. Another simulation assessment was repeated two months later in the same scenario. All simulation video recordings were assessed by two blinded experts using a validated checklist and an Anaesthetists' Non-Technical Skills (ANTS) scale in order to rate their technical and non-technical skills, respectively. The participants' performance (based on the above scales) in the two simulation sessions were then compared. Nineteen residents completed both simulation sessions. There was an improvement in the mean (SD) weighted checklist score from 64.5% (7.1%) in session 1 to 76.7% (6.7%) in session 2 (P technical skills but also the non-technical skills of residents, most likely due to the feedback received after the first simulation session. Repeated simulation sessions may help prepare residents to deal more effectively with similar critical situations in clinical practice with minimum errors.

  5. Task Engagement and Escape Maintained Challenging Behavior: Differential Effects of General and Explicit Cues when Implementing a Signaled Delay in the Delivery of Reinforcement

    Science.gov (United States)

    Reichle, Joe; Johnson, LeAnne; Monn, Emily; Harris, Michael

    2010-01-01

    This study was designed to evaluate the effects of explicit and general delay cues when implementing a tolerance for a delay in the delivery of a reinforcement procedure to increase task engagement and decrease escape maintained challenging behavior. Two preschool children with autism participated in an alternating treatments design with changing…

  6. "I Love Knowing That What I'm Doing Has Purpose": Male Instrumentalists Who Choose to Teach Elementary General Music

    Science.gov (United States)

    Shouldice, Heather Nelson

    2017-01-01

    Few entering music education students plan to teach in an elementary general music (EGM) setting, and the majority of those who teach EGM are female and have vocalist backgrounds. The purpose of this collective case study was to examine six male instrumentalists' decisions to pursue a career in EGM teaching rather than secondary instrumental…

  7. General Purpose Force Capability; the Challenge of Versatility and Achieving Balance Along the Widest Possible Spectrum of Conflict

    Science.gov (United States)

    2010-04-01

    conflict and managing competing resources. la rfare efined The 2006 Irregular Warfa re JOC defined Irregular Warfare as: “A violent struggle...general war from what was efined e s into fall of the Berlin Wall and the end of the Soviet conventi U.S. struggled to anticipate and failed to

  8. 三元乙丙橡胶对通用树脂的共混改性%EPDM on modification of general purpose resins

    Institute of Scientific and Technical Information of China (English)

    马国维; 方征平; 许承威

    2001-01-01

    总结了三元乙丙橡胶(EPDM)作为抗冲击改性剂对聚氯乙烯、聚乙烯、聚苯乙烯等通用树脂的改性及其机理,探讨了EPDM应用于通用树脂多组分共混的效果和前景,为大品种通用树脂共混改性提供了理论基础。%The methods and mechanisms of ethy-lene-propylene-diene monomer(EPDM) whichwas used as a a good impact modifier on the modi-fication of several general purpose resins,such aspolyvinyl chloride,polyethylene,polystyrene werereviewed. The effects and prospects of EPDM used inmulticomponent general resins blends were dis-cussed. A good theoretical foundation for the modi-fication of mixed general purpose resins was provid-ed.

  9. Bilingual Language Control and General Purpose Cognitive Control among Individuals with Bilingual Aphasia: Evidence Based on Negative Priming and Flanker Tasks

    OpenAIRE

    Tanya Dash; Kar, Bhoomika R.

    2014-01-01

    Background. Bilingualism results in an added advantage with respect to cognitive control. The interaction between bilingual language control and general purpose cognitive control systems can also be understood by studying executive control among individuals with bilingual aphasia. Objectives. The current study examined the subcomponents of cognitive control in bilingual aphasia. A case study approach was used to investigate whether cognitive control and language control are two separate syste...

  10. Bilingual language control and general purpose cognitive control among individuals with bilingual aphasia: evidence based on negative priming and flanker tasks.

    Science.gov (United States)

    Dash, Tanya; Kar, Bhoomika R

    2014-01-01

    Bilingualism results in an added advantage with respect to cognitive control. The interaction between bilingual language control and general purpose cognitive control systems can also be understood by studying executive control among individuals with bilingual aphasia. objectives: The current study examined the subcomponents of cognitive control in bilingual aphasia. A case study approach was used to investigate whether cognitive control and language control are two separate systems and how factors related to bilingualism interact with control processes. Four individuals with bilingual aphasia performed a language background questionnaire, picture description task, and two experimental tasks (nonlinguistic negative priming task and linguistic and nonlinguistic versions of flanker task). A descriptive approach was used to analyse the data using reaction time and accuracy measures. The cumulative distribution function plots were used to visualize the variations in performance across conditions. The results highlight the distinction between general purpose cognitive control and bilingual language control mechanisms. All participants showed predominant use of the reactive control mechanism to compensate for the limited resources system. Independent yet interactive systems for bilingual language control and general purpose cognitive control were postulated based on the experimental data derived from individuals with bilingual aphasia.

  11. 利用GPU进行通用数值计算的研究%Research on General-Purpose Computation Using GPU

    Institute of Scientific and Technical Information of China (English)

    徐品; 蓝善祯; 刘兰兰

    2009-01-01

    近年来,图形处理器(GPU)的发展日益成熟,应用范围不在局限于计算机图形学本身,已逐步扩展到通用数值计算领域.本文介绍了最新GPU用于通用计算的原理和方法,并在图像处理和科学计算方面对GPU和CPU算法进行了计算速度的对比研究,实验结果表明GPU在通用计算领域相对于CPU具有明显优势.%Recently, the development of Graphics Processing Unit (GPU) has become more and more sophisticated. The scope of application of GPU has been expanded to general purpose com-putations, except from those applications in graphics itself. In this paper, a detail introduction is given to the principles and methods of general purpose computation by GPU, and a comparative study of the calculation speed of GPU and CPU algorithm in image processing and scientific com-puting is made, and the experimental results show that GPU has an obvious advantage in general purpose computing compared with CPU.

  12. S2O - A software tool for integrating research data from general purpose statistic software into electronic data capture systems.

    Science.gov (United States)

    Bruland, Philipp; Dugas, Martin

    2017-01-07

    Data capture for clinical registries or pilot studies is often performed in spreadsheet-based applications like Microsoft Excel or IBM SPSS. Usually, data is transferred into statistic software, such as SAS, R or IBM SPSS Statistics, for analyses afterwards. Spreadsheet-based solutions suffer from several drawbacks: It is generally not possible to ensure a sufficient right and role management; it is not traced who has changed data when and why. Therefore, such systems are not able to comply with regulatory requirements for electronic data capture in clinical trials. In contrast, Electronic Data Capture (EDC) software enables a reliable, secure and auditable collection of data. In this regard, most EDC vendors support the CDISC ODM standard to define, communicate and archive clinical trial meta- and patient data. Advantages of EDC systems are support for multi-user and multicenter clinical trials as well as auditable data. Migration from spreadsheet based data collection to EDC systems is labor-intensive and time-consuming at present. Hence, the objectives of this research work are to develop a mapping model and implement a converter between the IBM SPSS and CDISC ODM standard and to evaluate this approach regarding syntactic and semantic correctness. A mapping model between IBM SPSS and CDISC ODM data structures was developed. SPSS variables and patient values can be mapped and converted into ODM. Statistical and display attributes from SPSS are not corresponding to any ODM elements; study related ODM elements are not available in SPSS. The S2O converting tool was implemented as command-line-tool using the SPSS internal Java plugin. Syntactic and semantic correctness was validated with different ODM tools and reverse transformation from ODM into SPSS format. Clinical data values were also successfully transformed into the ODM structure. Transformation between the spreadsheet format IBM SPSS and the ODM standard for definition and exchange of trial data is feasible

  13. 从图形处理器到基于GPU的通用计算%From Graphic Processing Unit to General Purpose Graphic Processing Unit

    Institute of Scientific and Technical Information of China (English)

    刘金硕; 刘天晓; 吴慧; 曾秋梅; 任梦菲; 顾宜淳

    2013-01-01

    对GPU(graphic process unit)、基于GPU的通用计算(general purpose GPU,GPGPU)、基于GPU的编程模型与环境进行了界定;将GPU的发展分为4个阶段,阐述了GPU的架构由非统一的渲染架构到统一的渲染架构,再到新一代的费米架构的变化;通过对基于GPU的通用计算的架构与多核CPU架构、分布式集群架构进行了软硬件的对比.分析表明:当进行中粒度的线程级数据密集型并行运算时,采用多核多线程并行;当进行粗粒度的网络密集型并行运算时,采用集群并行;当进行细粒度的计算密集型并行运算时,采用GPU通用计算并行.最后本文展示了未来的GPGPU的研究热点和发展方向--GPGPU自动并行化、CUDA对多种语言的支持、CUDA的性能优化,并介绍了GPGPU的一些典型应用.%This paper defines the outline of GPU(graphic processing unit) , the general purpose computation, the programming model and the environment for GPU. Besides, it introduces the evolution process from GPU to GPGPU (general purpose graphic processing unit) , and the change from non-uniform render architecture to the unified render architecture and the next Fermi architecture in details. Then it compares GPGPU architecture with multi-core GPU architecture and distributed cluster architecture from the perspective of software and hardware. When doing the middle grain level thread data intensive parallel computing, the multi-core and multi-thread should be utilized. When doing the coarse grain network computing, the cluster computing should be utilized. When doing the fine grained compute intensive parallel computing, the general purpose computation should be adopted. Meanwhile, some classical applications of GPGPU have been mentioned. At last, this paper demonstrates the further developments and research hotspots of GPGPU, which are automatic parallelization of GPGPU, multi-language support and performance optimization of CUDA, and introduces the classic

  14. The time-resolved and extreme conditions XAS (TEXAS) facility at the European Synchrotron Radiation Facility: the general-purpose EXAFS bending-magnet beamline BM23

    Energy Technology Data Exchange (ETDEWEB)

    Mathon, O., E-mail: mathon@esrf.fr; Beteva, A.; Borrel, J.; Bugnazet, D.; Gatla, S.; Hino, R.; Kantor, I.; Mairs, T. [European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble Cedex 9 (France); Munoz, M. [European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble Cedex 9 (France); Université Joseph Fourier, 1381 rue de la Piscine, BP 53, 38041 Grenoble Cedex 9 (France); Pasternak, S.; Perrin, F.; Pascarelli, S. [European Synchrotron Radiation Facility, CS 40220, 38043 Grenoble Cedex 9 (France)

    2015-10-17

    BM23 is the general-purpose EXAFS bending-magnet beamline at the ESRF, replacing the former BM29 beamline in the framework of the ESRF upgrade. Its mission is to serve the whole XAS user community by providing access to a basic service in addition to the many specialized instruments available at the ESRF. BM23 offers high-signal-to-noise ratio EXAFS in a large energy range (5–75 keV), continuous energy scanning for quick-EXAFS on the second timescale and a micro-XAS station delivering a spot size of 4 µm × 4 µm FWHM. BM23 is the general-purpose EXAFS bending-magnet beamline at the ESRF, replacing the former BM29 beamline in the framework of the ESRF upgrade. Its mission is to serve the whole XAS user community by providing access to a basic service in addition to the many specialized instruments available at the ESRF. BM23 offers high signal-to-noise ratio EXAFS in a large energy range (5–75 keV), continuous energy scanning for quick-EXAFS on the second timescale and a micro-XAS station delivering a spot size of 4 µm × 4 µm FWHM. It is a user-friendly facility featuring a high degree of automation, online EXAFS data reduction and a flexible sample environment.

  15. Improved health care delivery in an inner-city well-baby clinic run by general practitioners

    OpenAIRE

    Rossdale, Michael; Clark, Carol; James, John

    1986-01-01

    The delivery of health care has been improved in an inner-city well-baby clinic by staffing the clinic with members of a primary health care team and by offering a therapeutic service together with a preventive service. Over a three-year period attendance at the clinic has doubled and the uptake of immunization has increased. Of children registered with the practice supplying the health care team, 95% are up to date with diphtheria, tetanus and polio immunizations and 93% have been immunized ...

  16. Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation.

    Science.gov (United States)

    Anselmo, Aaron C; Gilbert, Jonathan B; Kumar, Sunny; Gupta, Vivek; Cohen, Robert E; Rubner, Michael F; Mitragotri, Samir

    2015-02-10

    Targeted delivery of drugs and imaging agents to inflamed tissues, as in the cases of cancer, Alzheimer's disease, Parkinson's disease, and arthritis, represents one of the major challenges in drug delivery. Monocytes possess a unique ability to target and penetrate into sites of inflammation. Here, we describe a broad approach to take advantage of the natural ability of monocytes to target and deliver flat polymeric particles ("Cellular Backpacks") to inflamed tissues. Cellular backpacks attach strongly to the surface of monocytes but do not undergo phagocytosis due to backpack's size, disk-like shape and flexibility. Following attachment of backpacks, monocytes retain important cellular functions including transmigration through an endothelial monolayer and differentiation into macrophages. In two separate in vivo inflammation models, backpack-laden monocytes exhibit increased targeting to inflamed tissues. Cellular backpacks, and their abilities to attach to monocytes without impairing monocyte functions and 'hitchhike' to a variety of inflamed tissues, offer a new platform for both cell-mediated therapies and broad targeting of inflamed tissues.

  17. The new versatile general purpose surface-muon instrument (GPS) based on silicon photomultipliers for μSR measurements on a continuous-wave beam

    Science.gov (United States)

    Amato, A.; Luetkens, H.; Sedlak, K.; Stoykov, A.; Scheuermann, R.; Elender, M.; Raselli, A.; Graf, D.

    2017-09-01

    We report on the design and commissioning of a new spectrometer for muon-spin relaxation/rotation studies installed at the Swiss Muon Source (SμS) of the Paul Scherrer Institute (PSI, Switzerland). This new instrument is essentially a new design and replaces the old general-purpose surface-muon (GPS) instrument that has been for long the workhorse of the μSR user facility at PSI. By making use of muon and positron detectors made of plastic scintillators read out by silicon photomultipliers, a time resolution of the complete instrument of about 160 ps (standard deviation) could be achieved. In addition, the absence of light guides, which are needed in traditionally built μSR instrument to deliver the scintillation light to photomultiplier tubes located outside magnetic fields applied, allowed us to design a compact instrument with a detector set covering an increased solid angle compared with the old GPS.

  18. Software & Hardware Architecture of General-Purpose Graphics Processing Unit%GPU通用计算软硬件处理架构研究

    Institute of Scientific and Technical Information of China (English)

    谢建春

    2013-01-01

    现代GPU不仅是功能强劲的图形处理引擎,也是具有强大计算性能和存储带宽的高度并行可编程器件,能够与CPU构建完整的异构处理系统.而将GPU用于图形处理以外的计算,一般称之为GPU通用计算(General-Purpose computing on Graphics Processing Unit,GPGPU).对GPU通用计算的概念及分类、硬件架构及工作机制、软件环境及处理模型进行详细的研究,期望为GPU通用计算在航空嵌入式计算领域的进一步应用提供参考.

  19. High Precision Thermal, Structural and Optical Analysis of an External Occulter Using a Common Model and the General Purpose Multi-Physics Analysis Tool Cielo

    Science.gov (United States)

    Hoff, Claus; Cady, Eric; Chainyk, Mike; Kissil, Andrew; Levine, Marie; Moore, Greg

    2011-01-01

    The efficient simulation of multidisciplinary thermo-opto-mechanical effects in precision deployable systems has for years been limited by numerical toolsets that do not necessarily share the same finite element basis, level of mesh discretization, data formats, or compute platforms. Cielo, a general purpose integrated modeling tool funded by the Jet Propulsion Laboratory and the Exoplanet Exploration Program, addresses shortcomings in the current state of the art via features that enable the use of a single, common model for thermal, structural and optical aberration analysis, producing results of greater accuracy, without the need for results interpolation or mapping. This paper will highlight some of these advances, and will demonstrate them within the context of detailed external occulter analyses, focusing on in-plane deformations of the petal edges for both steady-state and transient conditions, with subsequent optical performance metrics including intensity distributions at the pupil and image plane.

  20. High Precision Thermal, Structural and Optical Analysis of an External Occulter Using a Common Model and the General Purpose Multi-Physics Analysis Tool Cielo

    Science.gov (United States)

    Hoff, Claus; Cady, Eric; Chainyk, Mike; Kissil, Andrew; Levine, Marie; Moore, Greg

    2011-01-01

    The efficient simulation of multidisciplinary thermo-opto-mechanical effects in precision deployable systems has for years been limited by numerical toolsets that do not necessarily share the same finite element basis, level of mesh discretization, data formats, or compute platforms. Cielo, a general purpose integrated modeling tool funded by the Jet Propulsion Laboratory and the Exoplanet Exploration Program, addresses shortcomings in the current state of the art via features that enable the use of a single, common model for thermal, structural and optical aberration analysis, producing results of greater accuracy, without the need for results interpolation or mapping. This paper will highlight some of these advances, and will demonstrate them within the context of detailed external occulter analyses, focusing on in-plane deformations of the petal edges for both steady-state and transient conditions, with subsequent optical performance metrics including intensity distributions at the pupil and image plane.

  1. General route to multifunctional uniform yolk/mesoporous silica shell nanocapsules: a platform for simultaneous cancer-targeted imaging and magnetically guided drug delivery.

    Science.gov (United States)

    Zhang, Lingyu; Wang, Tingting; Yang, Lei; Liu, Cong; Wang, Chungang; Liu, Haiyan; Wang, Y Andrew; Su, Zhongmin

    2012-09-24

    Hollow mesoporous SiO(2) (mSiO(2)) nanostructures with movable nanoparticles (NPs) as cores, so-called yolk-shell nanocapsules (NCs), have attracted great research interest. However, a highly efficient, simple and general way to produce yolk-mSiO(2) shell NCs with tunable functional cores and shell compositions is still a great challenge. A facile, general and reproducible strategy has been developed for fabricating discrete, monodisperse and highly uniform yolk-shell NCs under mild conditions, composed of mSiO(2) shells and diverse functional NP cores with different compositions and shapes. These NPs can be Fe(3)O(4) NPs, gold nanorods (GNRs), and rare-earth upconversion NRs, endowing the yolk-mSiO(2) shell NCs with magnetic, plasmonic, and upconversion fluorescent properties. In addition, multifunctional yolk-shell NCs with tunable interior hollow spaces and mSiO(2) shell thickness can be precisely controlled. More importantly, fluorescent-magnetic-biotargeting multifunctional polyethyleneimine (PEI)-modified fluorescent Fe(3)O(4)@mSiO(2) yolk-shell nanobioprobes as an example for simultaneous targeted fluorescence imaging and magnetically guided drug delivery to liver cancer cells is also demonstrated. This synthetic approach can be easily extended to the fabrication of multifunctional yolk@mSiO(2) shell nanostructures that encapsulate various functional movable NP cores, which construct a potential platform for the simultaneous targeted delivery of drug/gene/DNA/siRNA and bio-imaging.

  2. Hydrogen storage and delivery system development

    Energy Technology Data Exchange (ETDEWEB)

    Handrock, J.L.; Wally, K.; Raber, T.N. [Sandia National Labs., Livermore, CA (United States)

    1995-09-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

  3. Adapting machine learning techniques to censored time-to-event health record data: A general-purpose approach using inverse probability of censoring weighting.

    Science.gov (United States)

    Vock, David M; Wolfson, Julian; Bandyopadhyay, Sunayan; Adomavicius, Gediminas; Johnson, Paul E; Vazquez-Benitez, Gabriela; O'Connor, Patrick J

    2016-06-01

    Models for predicting the probability of experiencing various health outcomes or adverse events over a certain time frame (e.g., having a heart attack in the next 5years) based on individual patient characteristics are important tools for managing patient care. Electronic health data (EHD) are appealing sources of training data because they provide access to large amounts of rich individual-level data from present-day patient populations. However, because EHD are derived by extracting information from administrative and clinical databases, some fraction of subjects will not be under observation for the entire time frame over which one wants to make predictions; this loss to follow-up is often due to disenrollment from the health system. For subjects without complete follow-up, whether or not they experienced the adverse event is unknown, and in statistical terms the event time is said to be right-censored. Most machine learning approaches to the problem have been relatively ad hoc; for example, common approaches for handling observations in which the event status is unknown include (1) discarding those observations, (2) treating them as non-events, (3) splitting those observations into two observations: one where the event occurs and one where the event does not. In this paper, we present a general-purpose approach to account for right-censored outcomes using inverse probability of censoring weighting (IPCW). We illustrate how IPCW can easily be incorporated into a number of existing machine learning algorithms used to mine big health care data including Bayesian networks, k-nearest neighbors, decision trees, and generalized additive models. We then show that our approach leads to better calibrated predictions than the three ad hoc approaches when applied to predicting the 5-year risk of experiencing a cardiovascular adverse event, using EHD from a large U.S. Midwestern healthcare system.

  4. The design of CMOS general-purpose analog front-end circuit with tunable gain and bandwidth for biopotential signal recording systems.

    Science.gov (United States)

    Chen, Wei-Ming; Yang, Wen-Chia; Tsai, Tzung-Yun; Chiueh, Herming; Wu, Chung-Yu

    2011-01-01

    In this paper an 8-channel CMOS general-purpose analog front-end (AFE) circuit with tunable gain and bandwidth for biopotential signal recording systems is presented. The proposed AFE consists of eight chopper stabilized pre-amplifiers, an 8-to-1 analog multiplexer, and a programmable gain amplifier. It can be used to sense and amplify different kinds of biopotential signals, such as electrocorticogram (ECoG), electrocardiogram (ECG) and electromyogram (EMG). The AFE chip is designed and fabricated in 0.18-μm CMOS technology. The measured maximum gain of AFE is 60.8 dB. The low cutoff frequency can achieve as low as 0.8 Hz and high cutoff frequency can be adjusted from 200 Hz to 10 kHz to suit for different kinds of biopotential signals. The measured input-referred noise is 0.9 μV(rms), with the power consumption of 18μW per channel at 1.8-V power supply. And the noise efficiency factor (NEF) is only 1.3 for pre-amplifier.

  5. 多用途汉语方言语音数据库的设计%Design of general-purpose Chinese dialect speech database

    Institute of Scientific and Technical Information of China (English)

    高原; 顾明亮; 孙平; 王侠; 张长水

    2012-01-01

    建立了一个多用途汉语方言语音数据库,用于说话人信息处理、方言特征词识别、语音识别等领域的研究.以多通道的方式采集时长106小时的语音数据,包括七种主要的汉语方言区语音,对数据进行预处理.在此基础上提出了汉语方言数据库的设计标准以及实施方案,有助于推动汉语语音库特别是方言语音库的建立.%This paper describes a general-purpose Chinese dialect speech database, which can be applied to speaker information analysis, character-words recognition, speech recognition etc. The speech database, which includes seven kinds of most common Chinese dialects, has reached one hundred and six hours by multi-channel record modes and has already preprocessed. Based on the work, the design criteria and implementation scheme of Chinese dialects speech database are proposed, which is useful for the establishment of Chinese speech database, especially Chinese dialect speech database.

  6. 图形处理器在通用计算中的应用%Application of graphics processing unit in general purpose computation

    Institute of Scientific and Technical Information of China (English)

    张健; 陈瑞

    2009-01-01

    基于图形处理器(GPU)的计算统一设备体系结构(compute unified device architecture,CUDA)构架,阐述了GPU用于通用计算的原理和方法.在Geforce8800GT下,完成了矩阵乘法运算实验.实验结果表明,随着矩阵阶数的递增,无论是GPU还是CPU处理,速度都在减慢.数据增加100倍后,GPU上的运算时间仅增加了3.95倍,而CPU的运算时间增加了216.66倍.%Based on the CUDA (compute unified device architecture) of GPU (graphics processing unit), the technical fundamentals and methods for general purpose computation on GPU are introduced. The algorithm of matrix multiplication is simulated on Geforce8800 GT. With the increasing of matrix order, algorithm speed is slowed either on CPU or on GPU. After the data quantity increases to 100 times, the operation time only increased in 3.95 times on GPU, and 216.66 times on CPU.

  7. Real-Time and Real-Fast Performance of General-Purpose and Real-Time Operating Systems in Multithreaded Physical Simulation of Complex Mechanical Systems

    Directory of Open Access Journals (Sweden)

    Carlos Garre

    2014-01-01

    Full Text Available Physical simulation is a valuable tool in many fields of engineering for the tasks of design, prototyping, and testing. General-purpose operating systems (GPOS are designed for real-fast tasks, such as offline simulation of complex physical models that should finish as soon as possible. Interfacing hardware at a given rate (as in a hardware-in-the-loop test requires instead maximizing time determinism, for which real-time operating systems (RTOS are designed. In this paper, real-fast and real-time performance of RTOS and GPOS are compared when simulating models of high complexity with large time steps. This type of applications is usually present in the automotive industry and requires a good trade-off between real-fast and real-time performance. The performance of an RTOS and a GPOS is compared by running a tire model scalable on the number of degrees-of-freedom and parallel threads. The benchmark shows that the GPOS present better performance in real-fast runs but worse in real-time due to nonexplicit task switches and to the latency associated with interprocess communication (IPC and task switch.

  8. Effects of remifentanil on cardiovascular and bispectral index responses to endotracheal intubation in severe pre-eclamptic patients undergoing Caesarean delivery under general anaesthesia.

    Science.gov (United States)

    Yoo, K Y; Jeong, C W; Park, B Y; Kim, S J; Jeong, S T; Shin, M H; Lee, J

    2009-06-01

    We examined the effects of remifentanil on cardiovascular and bispectral index (BIS) responses to tracheal intubation and neonatal outcomes in pre-eclamptic patients undergoing Caesarean delivery under general anaesthesia. Forty-two women with severe pre-eclampsia were randomly assigned to receive either remifentanil 1 microg kg(-1) (n=21) or saline (n=21) over 30 s before induction of anaesthesia using thiopentone 4 mg kg(-1) and suxamethonium 1.5 mg kg(-1). Mean arterial pressure (MAP), heart rate (HR) and BIS values as well as plasma catecholamine concentrations were measured. Neonatal effects were assessed using Apgar scores and umbilical cord blood gas analysis. Induction with thiopentone caused a reduction in MAP and BIS in both remifentanil and control groups. Following the tracheal intubation MAP and HR increased in both groups, the magnitude of which was lower in the remifentanil group. BIS values also increased, of which magnitude did not differ between the groups. Norepinephrine concentrations increased significantly following the intubation in the control, while remained unaltered in the remifentanil group. The neonatal Apgar scores at 1 min were significantly lower in the remifentanil group than in the control. However, Apgar scores at 5 min, and umbilical artery and vein blood gas values were similar between the groups. These results suggest that a single bolus of 1 microg kg(-1) remifentanil effectively attenuates haemodynamic but not BIS responses to tracheal intubation in pre-eclamptic patients undergoing Caesarean delivery under general anaesthesia. However, its use was associated with maternal hypotension and neonatal respiratory depression requiring resuscitation.

  9. A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution.

    Science.gov (United States)

    Wu, Heyu; Pal, Debashish; O'Sullivan, Joseph A; Tai, Yuan-Chuan

    2008-01-01

    We developed a prototype system to evaluate the feasibility of using a PET insert device to achieve higher resolution from a general-purpose animal PET scanner. The system consists of a high-resolution PET detector, a computer-controlled rotation stage, and a custom mounting plate. The detector consists of a cerium-doped lutetium oxyorthosilicate array (12 x 12 crystals, 0.8 x 1.66 x 3.75 mm(3) each) directly coupled to a position-sensitive photomultiplier tube (PS-PMT). The detector signals were fed into the scanner electronics to establish coincidences between the 2 systems. The detector was mounted to a rotation stage that is attached to the scanner via the custom mounting plate after removing the transmission source holder. The rotation stage was concentric with the center of the scanner. The angular offset of the insert detector was calibrated via optimizing point-source images. In all imaging experiments, coincidence data were collected from 9 angles to provide 180 degrees sampling. A (22)Na point source was imaged at different offsets from the center to characterize the in-plane resolution of the insert system. A (68)Ge point source was stepped across the axial field of view to measure the sensitivity of the system. A 23.2-g mouse was injected with 38.5 MBq of (18)F-fluoride and imaged at 3 h after injection for 2 h. The transverse image resolution of the PET insert device ranges from 1.1- to 1.4-mm full width at half maximum (FWHM) without correction for the point-source dimension. This corresponds to approximately 33% improvement over the resolution of the original scanner (1.7- to 1.8-mm FWHM) in 2 of the 3 directions. The sensitivity of the device is 0.064% at the center of the field, 46-fold lower than the sensitivity of an existing animal PET scanner. The mouse bone scan had improved image resolution using the PET insert device over that of the existing animal PET scanner alone. We have demonstrated the feasibility of using a high-resolution insert

  10. Investigation of inflammation and tissue patterning in the gut using a Spatially Explicit General-purpose Model of Enteric Tissue (SEGMEnT.

    Directory of Open Access Journals (Sweden)

    Chase Cockrell

    2014-03-01

    Full Text Available The mucosa of the intestinal tract represents a finely tuned system where tissue structure strongly influences, and is turn influenced by, its function as both an absorptive surface and a defensive barrier. Mucosal architecture and histology plays a key role in the diagnosis, characterization and pathophysiology of a host of gastrointestinal diseases. Inflammation is a significant factor in the pathogenesis in many gastrointestinal diseases, and is perhaps the most clinically significant control factor governing the maintenance of the mucosal architecture by morphogenic pathways. We propose that appropriate characterization of the role of inflammation as a controller of enteric mucosal tissue patterning requires understanding the underlying cellular and molecular dynamics that determine the epithelial crypt-villus architecture across a range of conditions from health to disease. Towards this end we have developed the Spatially Explicit General-purpose Model of Enteric Tissue (SEGMEnT to dynamically represent existing knowledge of the behavior of enteric epithelial tissue as influenced by inflammation with the ability to generate a variety of pathophysiological processes within a common platform and from a common knowledge base. In addition to reproducing healthy ileal mucosal dynamics as well as a series of morphogen knock-out/inhibition experiments, SEGMEnT provides insight into a range of clinically relevant cellular-molecular mechanisms, such as a putative role for Phosphotase and tensin homolog/phosphoinositide 3-kinase (PTEN/PI3K as a key point of crosstalk between inflammation and morphogenesis, the protective role of enterocyte sloughing in enteric ischemia-reperfusion and chronic low level inflammation as a driver for colonic metaplasia. These results suggest that SEGMEnT can serve as an integrating platform for the study of inflammation in gastrointestinal disease.

  11. 4DCAPTURE: a general purpose software package for capturing and analyzing two- and three-dimensional motion data acquired from video sequences

    Science.gov (United States)

    Walton, James S.; Hodgson, Peter; Hallamasek, Karen; Palmer, Jake

    2003-07-01

    4DVideo is creating a general purpose capability for capturing and analyzing kinematic data from video sequences in near real-time. The core element of this capability is a software package designed for the PC platform. The software ("4DCapture") is designed to capture and manipulate customized AVI files that can contain a variety of synchronized data streams -- including audio, video, centroid locations -- and signals acquired from more traditional sources (such as accelerometers and strain gauges.) The code includes simultaneous capture or playback of multiple video streams, and linear editing of the images (together with the ancilliary data embedded in the files). Corresponding landmarks seen from two or more views are matched automatically, and photogrammetric algorithms permit multiple landmarks to be tracked in two- and three-dimensions -- with or without lens calibrations. Trajectory data can be processed within the main application or they can be exported to a spreadsheet where they can be processed or passed along to a more sophisticated, stand-alone, data analysis application. Previous attempts to develop such applications for high-speed imaging have been limited in their scope, or by the complexity of the application itself. 4DVideo has devised a friendly ("FlowStack") user interface that assists the end-user to capture and treat image sequences in a natural progression. 4DCapture employs the AVI 2.0 standard and DirectX technology which effectively eliminates the file size limitations found in older applications. In early tests, 4DVideo has streamed three RS-170 video sources to disk for more than an hour without loss of data. At this time, the software can acquire video sequences in three ways: (1) directly, from up to three hard-wired cameras supplying RS-170 (monochrome) signals; (2) directly, from a single camera or video recorder supplying an NTSC (color) signal; and (3) by importing existing video streams in the AVI 1.0 or AVI 2.0 formats. The

  12. Dosimetric verification of RapidArc treatment delivery

    DEFF Research Database (Denmark)

    Korreman, Stine; Medin, Joakim; Kjaer-Kristoffersen, Flemming

    2009-01-01

    doses. All plans were then delivered several times to verify consistency of the delivery. Gamma analysis was used to verify the correspondence between dose distributions. The temporal resolution of the delivery was analysed by investigating the arc segments between control points separately. RESULTS......: Overall, good agreement was observed between measured and calculated doses in most cases with gamma values above 1 in >95% of measured points. The reproducibility of delivery was also very high. Gamma analysis between two consecutive runs of the same delivery plan generally showed gamma values above 1......PURPOSE: Recently, Varian Medical Systems have announced the introduction of a new treatment technique, in which dose is delivered over a single gantry rotation with variable MLC positions, dose rate and gantry speed. In February 2008, a preclinical installation of the RapidArc beam delivery...

  13. Advanced development and using of space nuclear power systems as a part of transport power supply modules for general purpose spacecraft

    Science.gov (United States)

    Menshikov, Valery A.; Kuzin, Anatoly I.; Pavlov, Konstantin A.; Zatserkovny, Sergey P.; Kalmykov, Alexandr V.; Sorokin, Alexandr N.; Bulavatsky, Andrey Y.; Vasilkovsky, Vladimir V.; Zrodnikov, Anatoly V.; Trukhanov, Yuri L.; Nikolaev, Yuri V.; Bezzubtsev, Valery S.; Lutov, Evgeny I.; Pavshoock, Vladimir A.; Akimov, Vladimir N.; Arkhangelsky, Nicolay I.; Gladyshev, Sergey N.

    1996-03-01

    Nuclear transport power systems (NTPS) can provide solving such important science, commerce and defense tasks in space as radar surveillance, information affording, global ecological monitoring, defense of Earth from dangerous space objects, manufacturing in space, investigations of asteroids, comets and solar systems' planets (Kuzin et al. 1993a, 1993b). The creation of NTPS for real space systems, however, must be based on proved NTPS effectiveness in comparison with other power and propulsion systems such as, nonnuclear electric-rocket systems and so on. When the NTPS effectiveness is proved, the operation safety of such systems must be suited to the UN requirements for all stages of the life cycle in view of possible failures. A nuclear transport power module provides both a large amount of thermal and electrical power and a long acting time (about 6-7 years after completing the delivery task). For this reason such module is featured with the high power supplying-mass delivery effectiveness and the considerable increasing of the total effectiveness of a spacecraft with the module. In the report, the such NTPS three types, namely the system on the base of thermionic reactor-converter with electric rocket propulsion system (ERPS), the dual mode thermionic nuclear power system with pumping of working fluid through the active reactor zone, and the system on the base of the nuclear thermal rocket engine technology is compared with the transport power modules on the base of solar power system from the point of view of providing the highest degree of the effectiveness.

  14. Advanced development and using of space nuclear power systems as a part of transport power supply modules for general purpose spacecraft

    Energy Technology Data Exchange (ETDEWEB)

    Menshikov, V.A.; Kuzin, A.I.; Pavlov, K.A.; Zatserkovny, S.P. [Russian Federation Ministry of Defense Central, Scientific-Research Institute of Space Force, Moscow, K-160 (Russian Federation); Kalmykov, A.V.; Sorokin, A.N.; Bulavatsky, A.Y. [Russian Federation Ministry of Defense, Main Department of Space Force, Moscow, K-160 (Russian Federation); Vasilkovsky, V.V. [Russian Federation Ministry of Atomic Power, 26, Staromonetny St., Moscow, 101000 (Russia); Zrodnikov, A.V. [Russian Federation State Research Center, ``Institute of Physics and Power Engineering``, 1, Bondarenko Sq., Obninsk, Kaluga Region, 249020 (Russian Federation); Trukhanov, Y.L. [``Red Star`` State Enterprise, 1A, Electrolitny St., Moscow, 115230 (Russia); Nikolaev, Y.V. [Scientific Industrial Association ``Lutch``, 24, Zhelesnodorozhnaya St., Podolsk, Moscow Region, 142100 (Russia); Bezzubtsev, V.S. [Research and Development Institute of Power Engineering, Moscow, 101000 (Russia); Lutov, E.I. [Central Design Bureau for Machine Building, St. Petersburg, 195027 (Russia); Pavshoock, V.A. [Russian Research Center ``Kurchatov Institute``, 1, Kurchatov Sq., Moscow, 123182 (Russia); Akimov, V.N.; Arkhangelsky, N.I. [Scientific-Research Institute of Thermal Processes, 8/10, Onezhskaya St., Moscow, 125438 (Russia); Gladyshev, S.N. [State Rocket Center ``Design Bureau of Academician V.P. Makeev``, 1, Turgoyarskoe St., Miass, Tchelyabinsk Region, 456300 (Russia)

    1996-03-01

    Nuclear transport power systems (NTPS) can provide solving such important science, commerce and defense tasks in space as radar surveillance, information affording, global ecological monitoring, defense of Earth from dangerous space objects, manufacturing in space, investigations of asteroids, comets and solar systems{close_quote} planets (Kuzin {ital et} {ital al}. 1993a, 1993b). The creation of NTPS for real space systems, however, must be based on proved NTPS effectiveness in comparison with other power and propulsion systems such as, nonnuclear electric-rocket systems and so on. When the NTPS effectiveness is proved, the operation safety of such systems must be suited to the UN requirements for all stages of the life cycle in view of possible failures. A nuclear transport power module provides both a large amount of thermal and electrical power and a long acting time (about 6{endash}7 years after completing the delivery task). For this reason such module is featured with the high power supplying-mass delivery effectiveness and the considerable increasing of the total effectiveness of a spacecraft with the module. In the report, the such NTPS three types, namely the system on the base of thermionic reactor-converter with electric rocket propulsion system (ERPS), the dual mode thermionic nuclear power system with pumping of working fluid through the active reactor zone, and the system on the base of the nuclear thermal rocket engine technology is compared with the transport power modules on the base of solar power system from the point of view of providing the highest degree of the effectiveness. {copyright} {ital 1996 American Institute of Physics.}

  15. Joint purpose?

    DEFF Research Database (Denmark)

    Pristed Nielsen, Helene

    2013-01-01

    Starting from Crenshaw´s point that antiracism often fails to interrogate patriarchy and that feminism often reproduces racist practices (1991: 1252), this paper asks: What are the theoretical reasons for believing that feminism and anti-racism can be regarded as fighting for the joint purpose of...

  16. CONSIDERATIONS ABOUT READING COMPREHENSION IN THE SUBJECT ENGLISH FOR ACADEMIC PURPOSES / CONSIDERACIONES SOBRE LA COMPRENSIÓN LECTORA EN LA ASIGNATURA INGLÉS CON FINES GENERALES

    Directory of Open Access Journals (Sweden)

    Graciela Feliciana Mayo Castro

    2013-12-01

    Full Text Available Reading comprehension is one of the general abilities of English language in the teaching-learning process. This skill constitutes a cultural and a work device, and it is the basis that helps to acquire of a great amount of knowledge. This methodological suggestion facilitates the development of reading comprehension due to that it is a system of exercises which are organized in a hierarchical way that leads the students to better decode the message expressed in a text. Reading comprehension ability makes easier to decode a message not only in English language but in Spanish language as well. LA COMPRENSIÓN LECTORA EN LA ASIGNATURA INGLÉS CON FINES GENERALES AUTORAS: DIRECCIÓN PARA CORRESPONDENCIA: Departamento de Idiomas. Universidad de Las Tunas, Cuba. E-mail graciela@ult.edu.cu Fecha de recepción: 21\t-\t08\t-\t2013 Fecha de aceptación:\t30\t-\t11\t-\t2013 RESUMEN La comprensión lectora es una de las habilidades generales en el proceso de enseñanza-aprendizaje del idioma inglés, esta constituye un instrumento de trabajo y de cultura y es la base que facilita el aprendizaje de un gran cúmulo de conocimientos. La presente alternativa metodológica facilita el desarrollo de la habilidad de comprensión lectora pues parte de un sistema de ejercicios jerárquicamente organizados, lo que conllevan al estudiante a una decodificación más acertada del mensaje expresado en los textos. El desarrollo de esta habilidad les permite la decodificación de información tanto en la lengua inglesa como en la lengua materna.

  17. Research of general purpose computing technology based on graphic processing unit%基于图形处理器的通用计算技术的研究

    Institute of Scientific and Technical Information of China (English)

    戴长江; 张尤赛

    2013-01-01

    In order to research the general purpose computing technology of GPU based on PC, the classic GPU general pur-pose computing method base on texture mapping technology was adopted, and the experiments of discrete convolution of 2D images and volume rendering based on 3D texture mapping were carried out. The experiment result indicates that, on the basis of a suitable algorithm design, the classic GPU general purpose computing technology can significantly enhance the program run-ning performance. In this article, it is concluded that the CPU+GPU heterogeneous computing mode will become a choice for high-performance computation, and the further development of the general purpose computing technology based on GPU is prospected.%为了研究基于PC的图形处理器(GPU)的通用计算技术,采用了基于纹理映射的经典GPU通用计算方法,进行了二维图像离散卷积和三维纹理映射体绘制的实验.实验证明了经典GPU通用计算技术在合适的算法设计基础上能够显著提升程序的运算速度,得出了基于CPU+GPU的异构计算模式可以成为高性能计算的一种选择的结论,展望了基于图形处理器的通用计算技术在未来的发展.

  18. Readiness of the Belgian network of sentinel general practitioners to deliver electronic health record data for surveillance purposes: results of survey study

    Directory of Open Access Journals (Sweden)

    Vanthomme Katrien

    2010-06-01

    Full Text Available Abstract Background In order to proceed from a paper based registration to a surveillance system that is based on extraction of electronic health records (EHR, knowledge is needed on the number and representativeness of sentinel GPs using a government-certified EHR system and the quality of EHR data for research, expressed in the compliance rate with three criteria: recording of home visits, use of prescription module and diagnostic subject headings. Methods Data were collected by annual postal surveys between 2005 and 2009 among all sentinel GPs. We tested relations between four key GP characteristics (age, gender, language community, practice organisation and use of a certified EHR system by multivariable logistic regression. The relation between EHR software package, GP characteristics and compliance with three quality criteria was equally measured by multivariable logistic regression. Results A response rate of 99% was obtained. Of 221 sentinel GPs, 55% participated in the surveillance without interruption from 2005 onwards, i.e. all five years, and 78% were participants in 2009. Sixteen certified EHR systems were used among 91% of the Dutch and 63% of the French speaking sentinel GPs. The EHR software package was strongly related to the community and only one EHR system was used by a comparable number of sentinel GPs in both communities. Overall, the prescription module was always used and home visits were usually recorded. Uniform subject headings were only sometimes used and the compliance with this quality criterion was almost exclusively related to the EHR software package in use. Conclusions The challenge is to progress towards a sentinel network of GPs delivering care-based data that are (partly extracted from well performing EHR systems and still representative for Belgian general practice.

  19. Teaching English for Specific Purposes

    Directory of Open Access Journals (Sweden)

    Nijolė Netikšienė

    2011-04-01

    Full Text Available Teaching English for Specific Purposes and General English is analysed in the article. The scientific approach of a scientist M. Rosenberg is presented. The experience of teaching English for Specific Purposesat VGTU is alsopresented. The ideas and teaching methods from the classes of general English can be transferred to the classes of English for Specific Purposes.

  20. Photovoltaics module interface: General purpose primers

    Science.gov (United States)

    Boerio, J.

    1985-01-01

    The interfacial chemistry established between ethylene vinyl acetate (EVA) and the aluminized back surface of commercial solar cells was observed experimentally. The technique employed is called Fourier Transform Infrared (FTIR) spectroscopy, with the infrared signal being reflected back from the aluminum surface through the EVA film. Reflection infrared (IR) spectra are given and attention is drawn to the specific IR peak at 1080/cm which forms on hydrolytic aging of the EVA/aluminum system. With this fundamental finding, and the workable experimental techniques, candidate silane coupling agents are employed at the interface, and their effects on eliminating or slowing hydrolytic aging of the EVA/aluminum interface are monitored.

  1. Evaluation of Prototype General Purpose Visor Concepts

    Science.gov (United States)

    2006-03-01

    particles, laser, solar and UV radiation (ballistic eyewear) and to protect the eyes and face from high-energy fragments (ballistic visor). A Human...deux parties pour protéger les yeux contre les fragments, les particules et les rayons laser, solaires et UV à faible énergie, (lunettes balistiques...low energy fragments, particles, laser, solar and UV radiation (ballistic eyewear) and to protect the eyes and face from high-energy fragments

  2. A General Purpose Ionospheric Ray Tracing Procedure

    Science.gov (United States)

    1993-08-01

    PUBUC RELEASE UNCLASSIFIED i IIt ii 11 UNCLASSIFIED DST0O A U S T R A L I A SURVEILLANCE RESEARCH LABORATORY ZDMC QUAIrrY High Frequency Radar ...tol = tolerance (Kms) at each step of raytracing (a value of * * l.d-6 is sufficient in most cases) * * CHARACTER * * cha - ’y’ if magnetic fields...Director, Surveillance Research Laboratory 1 Chief High Frequency Radar Division 1 Research Leader, Jindalee Operational Radar Network 1 Head, Radar

  3. Forceps Delivery

    Science.gov (United States)

    ... in place to control the advance of your baby's head. Forceps deliveries aren't always successful. If your health care ... com. Accessed June 12, 2015. You and your baby: Prenatal care, labor and delivery, and postpartum care. Washington, D.C.: The American ...

  4. State of the art and future research on general purpose computation of Graphics Processing Unit%图形处理器通用计算的研究综述

    Institute of Scientific and Technical Information of China (English)

    陈庆奎; 王海峰; 那丽春; 霍欢; 郝聚涛; 刘伯成

    2012-01-01

    从2004年开始,图形处理器GPU的通用计算成为一个新研究热点,此后GPGPU( General-Purpose Graphics Processing Unit)在最近几年中取得长足发展.从介绍GPGPU硬件体系结构的改变和软件技术的发展开始,阐述GPGPU主要应用领域中的研究成果及最新发展.针对各种应用领域中计算数据大规模增加的趋势,出现单个GPU计算节点无法克服的硬件限制问题,为解决该问题出现多GPU计算和GPU集群的解决方案.详细地讨论通用计算GPU集群的研究进展和应用技术,包括GPU集群硬件异构性的问题和软件框架的三个研究趋势,对几种典型的软件框架Glift、Zippy、CUDASA的特性和缺点进行较详细的分析.最后,总结GPU通用计算研究发展中存在的问题和未来的挑战.%The general purpose computation of graphic processing unit became a new research field since 2004. GPGPU has been developing rapidly in recent years at a high speed. Starting from an introduction to the development of the architecture of GPU for general-purpose computation and software technology, the study and development of GPU for general-purpose computation are introduced. Aiming at the large scale data of various application fields, GPU cluster is proposed to overcome the limitation of single GPU. So the development and application technologies of GPGPU cluster are discussed and include the issue of heterogeneous cluster and the trend of software for GPU cluster. Several frameworks for GPU cluster are analyzed in detailed, such as Glift, Zippy, and CUDASA. Finally, the unsolved problems and the new challenge in this subject are proposed.

  5. 现代信息化背景下重塑监狱行刑一般预防目的%Reshaping the Purpose of General Prevention of Prison Execution under the Background of Modern Informatization

    Institute of Scientific and Technical Information of China (English)

    杨锦芳

    2015-01-01

    国家对监狱行刑的刑罚目的包括一般预防的期待。这一点可从刑罚权的本质和监狱在刑罚执行中的地位得以证明。监狱行刑通过对罪犯的惩罚产生威慑功能,实现一般预防目的,并在此基础上使民众确信法律保护大多数人权利的事实,对法律产生信赖,最终实现积极一般预防目的。然而,在传统行刑模式下,由于监狱的封闭性、惩罚失衡性和改造失当性等问题的客观存在,弱化了监狱行刑功能。监狱信息化工作的开展,为实现狱务公开、依法治监,打破封闭状态提供了强大的技术支撑,强化监狱行刑一般预防目的的实现。%One of the purposes of prison execution is general prevention,which can be seen from the nature of penalty power and the status of prison punishment in criminal execution.Prison execution punishment of criminals causes deterring function and realizes the purpose of positive general prevention.And on this basis,it convinces people that laws have the function of protec-ting the rights of most people,and finally achieve the purpose of active general prevention.However,problems like prison block,punishment imbalance and improper transformation have weakened the function of prison execution in the traditional mode of execution.Now with the development of prison informatization,it is possible to achieve the opening of prison affairs,adminis-tering prisons according to law and breaking the closed state of prisons and to facilitate the realization of the purpose of general prevention of prison execution.

  6. Synthesis of [1-{sup 11}C]octanoic acid, [{sup 11}C]raclopride and [{sup 11}C]nicergoline with a general-purpose automated synthesis apparatus of {sup 11}C-labeled radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Yajima, Kazuyosi; Kawashima, Hidefumi; Cui, Ying-she; Hashimoto, Naoto; Miyake, Yoshihiro [National Cardiovascular Center, Suita, Osaka (Japan)

    1997-06-01

    We have developed a general-purpose automated synthesis apparatus of {sup 11}C-labeled radiopharmaceuticals for PET, which can be adopted to both one-pot and two-or-more-pot reactions. The features of the apparatus were shown in the successful preparation of [(1-{sup 11})C]octanoic acid in a one-pot reaction and [{sup 11}C]raclopride and [{sup 11}C]nicergoline in two-pot reactions, the latter being a novel radiopharmaceutical. (author).

  7. Microfluidic electroporation for cellular analysis and delivery.

    Science.gov (United States)

    Geng, Tao; Lu, Chang

    2013-10-01

    Electroporation is a simple yet powerful technique for breaching the cell membrane barrier. The applications of electroporation can be generally divided into two categories: the release of intracellular proteins, nucleic acids and other metabolites for analysis and the delivery of exogenous reagents such as genes, drugs and nanoparticles with therapeutic purposes or for cellular manipulation. In this review, we go over the basic physics associated with cell electroporation and highlight recent technological advances on microfluidic platforms for conducting electroporation. Within the context of its working mechanism, we summarize the accumulated knowledge on how the parameters of electroporation affect its performance for various tasks. We discuss various strategies and designs for conducting electroporation at the microscale and then focus on analysis of intracellular contents and delivery of exogenous agents as two major applications of the technique. Finally, an outlook for future applications of microfluidic electroporation in increasingly diverse utilities is presented.

  8. Study on the Modified of General-purpose Antistatic Agent to High Polymer Material%通用型抗静电剂对高聚物材料的改性研究

    Institute of Scientific and Technical Information of China (English)

    张玉广; 刘生满; 黄犇犇; 张景昌

    2009-01-01

    This paper introduces the polymerization technology and principle of general-purpose antistatic agent. The process, the temperature, the vacuum, and the time of reaction influence on polymerization. The material rate influences on the antistatic properties and anti-washing properties. It introduces the modification process of high polymer material and polyester-cotton fabric. After general-purpose antistatic agent dealing with polyester-cotton fabric,surface resistance of polyester-cotton fabric is still 3.1 108Ω and polyester fabric is 5.5 × 108Ω for 50 standard washing , half-period of the fabricless than0.5s.%研究了通用型抗静电聚合的机理及聚合的工艺流程分析了温度、真空度和反应时间对聚合质量的影响以及物料比对抗静电性能和耐洗性的影响,探讨了高聚物、涤棉面料的改性工艺.实验表明,经通用型抗静电剂处理的涤棉面料标准洗涤50次后表面电阻仍为3.1×108Ω,涤卡面料标准洗涤50次后表面电阻仍为5.5×108Ω,半衰期均小于0.5 s.

  9. Communicative Purpose as Genre Determinant

    DEFF Research Database (Denmark)

    Askehave, Inger

    1999-01-01

    Through the years researchers and LSP teachers alike have used various parameters for classifying texts. This article sets out to discuss the notion of "communicative purpose" as a means for classifying text. It points to some of the difficulties associated with the functional approaches to genre...... classification in general and the notion of "communicative purpose" in particular....

  10. Comparing Online and In-Person Delivery Formats of the OSHA 10-Hour General Industry Health and Safety Training for Young Workers.

    Science.gov (United States)

    Shendell, Derek G; Milich, Lindsey J; Apostolico, Alexsandra A; Patti, Alexa A; Kelly, Siobhan

    2017-05-01

    Seven school districts or comprehensive high schools were enrolled in online OSHA 10-hour General Industry or Construction health and safety training via CareerSafe to determine the feasibility of online training for students, given limited resources for in-person trainings. A two-campus school district was analyzed comparing OSHA 10 for General Industry across in-person, supervisor-level teachers as authorized trainers, and online course formats. The online training courses were completed by 86 of 91 students, while another 53 of 57 students completed in-person training. Both groups completed identical OSHA-approved quizzes for "Introduction to OSHA," the initial 2-h module consistently provided in OSHA 10 courses across topics and formats. Results indicated teacher supervision was critical, and girls had higher online course completion rates, overall quiz scores, and never failed. Though both cohorts passed, in-person had significantly higher scores than online; both struggled with two questions. Online OSHA 10 for General Industry can be an efficient learning tool for students when limited resources prevent widespread availability of in-person courses.

  11. 全麻对剖宫产胎儿影响的临床研究%Clinical study of the influence of general anesthesia on cesarean delivery fetus

    Institute of Scientific and Technical Information of China (English)

    李莉; 苏利

    2014-01-01

    Objective To compare the influence of general anesthesia and combined spinal-epidural anesthesia on neonatal Apgar score. Methods A total of 65 cases of single pregnancy to full term undergone cesarean section were taken as study subjects. There were 32 cases in the general anesthesia group received general anesthesia due to intraspinal anesthesia taboo, and the other 33 cases in the combined spinal-epidural anesthesia group received combined spinal-epidural anesthesia. The fetal childbirth time, birth weight, and apgar score at 1 min and 5 min were recorded. Results Apgar score at 1 min of general anesthesia group and combined spinal-epidural anesthesia group were (9.5±0.8) points and (9.8±0.6) points respectively, and there was no significant difference between the two groups (P>0.05). Apgar scores at 5 min were all 10 points in the two groups. Conclusion General anesthesia and combined spinal-epidural anesthesia have no obviously variant influences on fetus.%目的:比较剖宫产施行全身麻醉(全麻)和腰硬联合麻醉对新生儿Apgar评分的影响。方法选择足月单胎妊娠行择期剖宫产的产妇65例,椎管内麻醉禁忌而需使用全麻的剖宫产为全麻组32例,其余33例行腰硬联合麻醉作为腰硬联合麻醉组。记录胎儿娩出时间,新生儿体重和1、5 min的Apgar评分。结果全麻组和腰硬联合麻醉组新生儿1 min的Apgar评分分别为(9.5±0.8)分、(9.8±0.6)分,两组差异无统计学意义(P>0.05)。5 min Apgar评分均为10分。结论全麻和硬联合麻醉对胎儿的影响没有明显差异。

  12. 基于DSP控制的全数字直流PWM调速系统%Research on Software Platform of General- Purpose Digital Speed Regulation System Based on DSP Controller

    Institute of Scientific and Technical Information of China (English)

    刘龙江; 边鑫

    2012-01-01

    针对现存电压闭环和电流闭环直流调速系统各自的不足,首先对其结构进行了改进,分析研究了一种电压/电流双闭环直流调速系统.随后设计了一种基于DSP控制器的通用电机调速系统,并将其应用于电动车驱动系统电机控制中,实验结果表明,系统工作可靠稳定.%Firstly,according to the deficiency of the voltage closed - loop speed regulation system with the end current, a new kind of direct current speed regulation system based on voltage control strategy is put forward in this thesis, that is voltage/current double - closed - loop direct current speed regulation system. Secondly, in order to speed up the developing process of all sort of speed regulation system on the basis of DSP, a software platform of the general - purpose digital speed regulation system is devised. It is used successfully in the current closed - loop DC speed regulation system of EV.

  13. Liposomal dry powders as aerosols for pulmonary delivery of proteins

    OpenAIRE

    Lu, Dongmei; Hickey, Anthony J.

    2005-01-01

    The purpose of this research was to develop liposomal dry powder aerosols for protein delivery. The delivery of stable protein formulations is essential for protein subunit vaccine delivery, which requires local delivery to macrophages in the lungs. β-Glucuronidase (GUS) was used as a model protein to evaluate dry powder liposomes as inhaled delivery vehicles. Dimyristoyl phosphatylcholine:cholesterol (7∶3) was selected as the liposome composition. The lyophilization of liposomes, micronizati...

  14. 77 FR 10529 - Federal Acquisition Regulation; Information Collection; Delivery Schedules

    Science.gov (United States)

    2012-02-22

    ..., Time of Delivery, or FAR 52.211-9, Desired and Required Time of Delivery. The information is needed to... Regulation; Information Collection; Delivery Schedules AGENCY: Department of Defense (DOD), General Services... requirement concerning delivery schedules. Public comments are particularly invited on: Whether this...

  15. Aptamer-Gated Nanoparticles for Smart Drug Delivery

    Directory of Open Access Journals (Sweden)

    Huseyin Avni Oktem

    2011-08-01

    Full Text Available Aptamers are functional nucleic acid sequences which can bind specific targets. An artificial combinatorial methodology can identify aptamer sequences for any target molecule, from ions to whole cells. Drug delivery systems seek to increase efficacy and reduce side-effects by concentrating the therapeutic agents at specific disease sites in the body. This is generally achieved by specific targeting of inactivated drug molecules. Aptamers which can bind to various cancer cell types selectively and with high affinity have been exploited in a variety of drug delivery systems for therapeutic purposes. Recent progress in selection of cell-specific aptamers has provided new opportunities in targeted drug delivery. Especially functionalization of nanoparticles with such aptamers has drawn major attention in the biosensor and biomedical areas. Moreover, nucleic acids are recognized as an attractive building materials in nanomachines because of their unique molecular recognition properties and structural features. A active controlled delivery of drugs once targeted to a disease site is a major research challenge. Stimuli-responsive gating is one way of achieving controlled release of nanoparticle cargoes. Recent reports incorporate the structural properties of aptamers in controlled release systems of drug delivering nanoparticles. In this review, the strategies for using functional nucleic acids in creating smart drug delivery devices will be explained. The main focus will be on aptamer-incorporated nanoparticle systems for drug delivery purposes in order to assess the future potential of aptamers in the therapeutic area. Special emphasis will be given to the very recent progress in controlled drug release based on molecular gating achieved with aptamers.

  16. Nanoparticle Delivery Enhancement With Acoustically Activated Microbubbles

    Science.gov (United States)

    Mullin, Lee B; Phillips, Linsey C; Dayton, Paul A

    2013-01-01

    The application of microbubbles and ultrasound to deliver nanoparticle carriers for drug and gene delivery is an area that has expanded greatly in recent years. Under ultrasound exposure, microbubbles can enhance nanoparticle delivery by increasing cellular and vascular permeability. In this review, the underlying mechanisms of enhanced nanoparticle delivery with ultrasound and microbubbles and various proposed delivery techniques are discussed. Additionally, types of nanoparticles currently being investigated in preclinical studies, as well as the general limitations and benefits of a microbubble-based approach to nanoparticle delivery are reviewed. PMID:23287914

  17. Premature delivery

    Directory of Open Access Journals (Sweden)

    Bernardita Donoso Bernales

    2012-09-01

    Full Text Available Preterm delivery is the single most important cause of perinatal morbidity and mortality. In Chile, preterm births have increased in the past decade, although neonatal morbidity and mortality attributable to it shows a downward trend, thanks to improvements in neonatal care of premature babies, rather than the success of obstetric preventive and therapeutic strategies. This article describes clinical entities, disease processes and conditions that constitute predisposing factors of preterm birth, as well as an outline for the prevention and clinical management of women at risk of preterm birth.

  18. 12 500 DWT重吊多用途船总体设计研究%Research of General Design for 12 500 DWT Heavy Lift Multi-purpose Vessel

    Institute of Scientific and Technical Information of China (English)

    樊红元; 杨博; 向淼

    2016-01-01

    12500 DWT多用途船是一型重吊多用途船,满足EEDI、压载水处理、拆船公约等最新的国际规范和环保要求,配备重型起货设备,拥有超长货舱、超大甲板面积,主要用于装运大型工程设备、重货、集装箱、干散货、谷物及危险品等.文章对其总体布置、破舱稳性、主推进装置和节能环保措施等方面进行了研究.该船采用先进的主推进装置,选用超长两冲程G型电喷主机,配隧道式齿轮箱和轴带发电机,定距螺旋桨推进,其燃油经济性优秀.%The 12 500 DWT heavy lift multi-purpose vessel fulfills the latest rules,regulations and environment protection requirements including EEDI,ballast water treatment and recycling of ships etc.The vessel is built with heavy-lifts,supper long cargo hold and supper large weather deck area,to be used for carrying long pieces,heavy cargoes,containers,dry bulk cargoes,grain cargoes and dangerous goods.The technology problems of general arrangement,damage stability,main propulsion system,energy saving and environment protection are studied.Ultra long two strokes electronic controlled fuel injection G type main engine,tunnel gear box,shaft generator and fixed pitch propeller are used for advanced main propulsion system.It provides the outstanding fuel consumption performance.

  19. Parallel Algorithm Based on General Purpose Computing on GPU and the Implementation of Calculation Framework%基于GPU通用计算的并行算法和计算框架的实现

    Institute of Scientific and Technical Information of China (English)

    朱宇兰

    2016-01-01

    GPU通用计算是近几年来迅速发展的一个计算领域,以其强大的并行处理能力为密集数据单指令型计算提供了一个绝佳的解决方案,但受限制于芯片的制造工艺,其运算能力遭遇瓶颈。本文从GPU通用计算的基础——图形API开始,分析GPU并行算法特征、运算的过程及特点,并抽象出了一套并行计算框架。通过计算密集行案例,演示了框架的使用方法,并与传统GPU通用计算的实现方法比较,证明了本框架具有代码精简、与图形学无关的特点。%GPGPU(General Purpose Computing on Graphics Processing Unit) is a calculation mothed that develops quiet fast in recent years, it provide an optimal solution for the intensive data calculation of a single instruction with a powerful treatment, however it is restricted in CPU making process to lead to entounter the bottleneck of hardware manufacture. This paper started from GPGPU by Graphics API to analyze the featuers, progress and characteristics of GPU parallel algorithm and obtained a set of computing framework to demonstrate it by an intensive line calculation and compared between the traditional GPU and the parallel computing framework to turn out to show that there was a simplified code and had nothing to do with graphics.

  20. Film coatings for oral colon delivery.

    Science.gov (United States)

    Maroni, Alessandra; Del Curto, Maria Dorly; Zema, Lucia; Foppoli, Anastasia; Gazzaniga, Andrea

    2013-12-05

    Oral colon delivery is pursued through a number of formulation strategies with the aim of enabling effective and well-tolerated treatments for large bowel pathologies or enhancing the intestinal absorption of peptide and protein drugs. According to such strategies, coated dosage forms for colonic release may be provided with microbiota, pH, pressure or time-dependent polymeric films. Microbiota-activated coatings are mostly obtained from polysaccharides of natural origin mixed with insoluble structuring excipients. Alternatively, synthetic azo compounds have been employed, generally requiring organic solvents for use as spray-coating agents. On the other hand, pH-sensitive films show responsiveness to pH changes in the lower gut, such as the rise generally observed in the terminal ileum and distal colon or the slight acidification of caecal contents by bacterial fermentation products. Pressure-sensitive coatings are intended for rupturing because of the relatively elevated pressure that may affect solid dosage forms in the large bowel. Finally, time-dependent films are expected to undergo timed erosion, break-up or permeabilization processes irrespective of the aforementioned physiological variables. In this review, the differing films applied for colon delivery purposes are surveyed, and details on their composition, manufacturing and performance are reported.

  1. 5 CFR 330.701 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... PLACEMENT (GENERAL) Interagency Career Transition Assistance Plan for Displaced Employees § 330.701 Purpose... interagency career transition assistance program for Federal employees during a period of severe...

  2. Cationic Bolaamphiphiles for Gene Delivery

    Science.gov (United States)

    Tan, Amelia Li Min; Lim, Alisa Xue Ling; Zhu, Yiting; Yang, Yi Yan; Khan, Majad

    2014-05-01

    Advances in medical research have shed light on the genetic cause of many human diseases. Gene therapy is a promising approach which can be used to deliver therapeutic genes to treat genetic diseases at its most fundamental level. In general, nonviral vectors are preferred due to reduced risk of immune response, but they are also commonly associated with low transfection efficiency and high cytotoxicity. In contrast to viral vectors, nonviral vectors do not have a natural mechanism to overcome extra- and intracellular barriers when delivering the therapeutic gene into cell. Hence, its design has been increasingly complex to meet challenges faced in targeting of, penetration of and expression in a specific host cell in achieving more satisfactory transfection efficiency. Flexibility in design of the vector is desirable, to enable a careful and controlled manipulation of its properties and functions. This can be met by the use of bolaamphiphile, a special class of lipid. Unlike conventional lipids, bolaamphiphiles can form asymmetric complexes with the therapeutic gene. The advantage of having an asymmetric complex lies in the different purposes served by the interior and exterior of the complex. More effective gene encapsulation within the interior of the complex can be achieved without triggering greater aggregation of serum proteins with the exterior, potentially overcoming one of the great hurdles faced by conventional single-head cationic lipids. In this review, we will look into the physiochemical considerations as well as the biological aspects of a bolaamphiphile-based gene delivery system.

  3. A Review on Foreign Research in General Purpose Technologies and Economic Growth%一般通用技术与经济增长的国外研究综述

    Institute of Scientific and Technical Information of China (English)

    潘维军

    2012-01-01

    技术进步是经济增长的源泉,但是以往研究关注的只是微小的、增量式的技术进步,这使得经济增长理论的解释能力受到局限。一般通用技术理论是20世纪90年代以来在经济增长领域发展起来的一种增长理论,与传统的经济增长理论不同,它关注具有广泛应用而且能够推动其他部门技术进步的重大技术进步。经济学家使用博弈论、DGE等方法对一般通用技术进行研究,并将其应用到其他领域,对经济增长停滞与波动、工资不平等等问题提出了全新而且相当有说服力的解释。通过对一般通用技术文献的回顾,本文一方面总结了一般通用技术理论研究取得的成果及在不同领域的应用;另一方面,在此基础上指出了一般通用技术研究中存在的理论问题以及进一步的发展方向。%It' s a common sense for economists that technological progress is the source of economic growth, but previous studies only care the micro and incremental technological progress, which makes the explanatory power of the economic growth theory limited. The general purpose technology (GPT) theory is a growth theory which was developed in 1990s. Being differ from the traditional economic growth theory,GPT theory pays close attention to those major technological progresses which are widely used to promote other sectors' technological progresses. Economists study the GPT by using game theory and DGE model, etc. , and apply it in other fields to put forward it a new and quite persuasive theory to explain the economic stagnation and fluctuation,wage inequality,etc. Through the review of GPT literatures, we summarize the GPT theory achievement and its application in different fields; on the other hand, based on generalizing the literatures,we point out the flaws in GPT literatures and the further development of the GPT theory.

  4. GLIMPS sensor and taggant delivery systems

    Science.gov (United States)

    Nunan, Scott C.; Coakley, Peter G.; Niederhaus, Gregory A.; Lum, Chris

    2001-02-01

    A system has been developed for delivering and attaching a sensor payload to a target using a standard 40-mm grenade launcher. The GLIMPS projectile is intended to be a general purpose delivery system for a variety of sensor payloads including visual, acoustic, and chemical sensors. The GLIMPS projectile flight characteristics are similar to existing 40-mm rounds, with a useful range of up to 300 m. The projectile incorporates an attachment mechanism, a shock mitigation system, a power source, and a telemetry system for transmission of sensor data at up to 1/4 mile range. A second design is also being considered. It is a small taggant projectile that uses an adhesive to attach a tracking transmitter or other small payload to a vehicle at up to 50 m range. While initially developed as a military system, both projectiles can be used to enhance law enforcement operations.

  5. Safety design integrated in the Building Delivery System

    DEFF Research Database (Denmark)

    Jørgensen, Kirsten

    2012-01-01

    of safety in each process. The group of participants who created the description had a high experience in a combination of research, safety and health in general and especial in construction and knowledge of the lean construction processes both from the clients perspective as well as from the designers...... phases of the building delivery system by using the principle of the lean construction modelling. The method for the research was to go through the lean construction building delivery system step by step and create a normative description of what to do, when to do and how to do to fully integration......It is important to see safety and health in construction as an integrated part of the way in which designers, architects, constructors, engineers and others carry out their consulting services. The purpose of this article is to demonstrate how safety and health can be integrated in the design...

  6. 18 CFR 3a.1 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Purpose. 3a.1 Section 3a.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES NATIONAL SECURITY INFORMATION General § 3a.1 Purpose. This part 3a describes...

  7. 23 CFR 656.1 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Purpose. 656.1 Section 656.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CARPOOL AND VANPOOL PROJECTS § 656.1 Purpose. The purpose of this regulation is to prescribe policies and general procedures...

  8. Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

    Science.gov (United States)

    Cunha, Ludmylla; Grenha, Ana

    2016-01-01

    In the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine resources, seaweed is a valuable source of structurally diverse bioactive compounds. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae and fucoidan in brown algae. Sulfated polysaccharides have been increasingly studied over the years in the pharmaceutical field, given their potential usefulness in applications such as the design of drug delivery systems. The purpose of this review is to discuss potential applications of these polymers in drug delivery systems, with a focus on carrageenan, ulvan and fucoidan. General information regarding structure, extraction process and physicochemical properties is presented, along with a brief reference to reported biological activities. For each material, specific applications under the scope of drug delivery are described, addressing in privileged manner particulate carriers, as well as hydrogels and beads. A final section approaches the application of sulfated polysaccharides in targeted drug delivery, focusing with particular interest the capacity for macrophage targeting. PMID:26927134

  9. Combining Purpose With Profits

    DEFF Research Database (Denmark)

    Julian Birkinshaw, Julian; Foss, Nicolai Juul; Lindenberg, Siegwart

    2014-01-01

    A sense of purpose that transcends making money can motivate employees. But to sustain both a sense of purpose and a solid level of profitability over time, companies need to pay attention to several fundamental organizing principles.......A sense of purpose that transcends making money can motivate employees. But to sustain both a sense of purpose and a solid level of profitability over time, companies need to pay attention to several fundamental organizing principles....

  10. Combining Purpose With Profits

    DEFF Research Database (Denmark)

    Julian Birkinshaw, Julian; Foss, Nicolai Juul; Lindenberg, Siegwart

    2014-01-01

    A sense of purpose that transcends making money can motivate employees. But to sustain both a sense of purpose and a solid level of profitability over time, companies need to pay attention to several fundamental organizing principles.......A sense of purpose that transcends making money can motivate employees. But to sustain both a sense of purpose and a solid level of profitability over time, companies need to pay attention to several fundamental organizing principles....

  11. Advanced drug delivery systems: Nanotechnology of health design A review

    Directory of Open Access Journals (Sweden)

    Javad Safari

    2014-04-01

    Full Text Available Nanotechnology has finally and firmly entered the realm of drug delivery. Performances of intelligent drug delivery systems are continuously improved with the purpose to maximize therapeutic activity and to minimize undesirable side-effects. This review describes the advanced drug delivery systems based on micelles, polymeric nanoparticles, and dendrimers. Polymeric carbon nanotubes and many others demonstrate a broad variety of useful properties. This review emphasizes the main requirements for developing new nanotech-nology-based drug delivery systems.

  12. Transdermal drug delivery

    OpenAIRE

    Prausnitz, Mark R.; Langer, Robert

    2008-01-01

    Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability ...

  13. The Direzione Generale per gli Affari Generali, il Bilancio, le Risorse Umane e la Formazione, in the re-organization of the Ministero per i Beni e le Attività Culturali: institutional purposes bent to Human Resources and Training

    Directory of Open Access Journals (Sweden)

    Alfredo Giacomazzi

    2004-02-01

    Full Text Available The plan for the training for 2005 is presented as part of the re-organization of the Ministry for Cultural Heritage and Activities and of the General Management for General Affairs, for the Budget, Human Resources and Training, in particular it is a presentation of the activities that the Administration wishes to carry out at an economic-financial level and in the management. To be more precise reference is made to the National Project “L-Lifelong Learning” – continuous learning with high technologies and basic computer training.

  14. 7 CFR 652.6 - Department delivery of technical services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Department delivery of technical services. 652.6... General Provisions § 652.6 Department delivery of technical services. (a) The Department may enter into a... technical assistance services that accelerate conservation program delivery. Related technical...

  15. The Special Purpose Vehicle

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2013-01-01

    The purpose of this article is to investigate whether the situation where two companies appear as originators or sponsors behind a Special Purpose Vehicle (SPV) can be described as a merger, although on micro scale. Are the underlying grounds behind the creation of an SPV much different than thos...

  16. Graduate Student Services: A Study of the Delivery of Services at the Location Where Students Matriculate

    Science.gov (United States)

    Burlison, John G.

    2010-01-01

    This dissertation investigates and explores the best method for the delivery of graduate student services. Essentially, there are two methods for delivery of these services. They can be delivered by virtue of centralization or decentralization. Decentralized delivery, for the purpose of this dissertation is the delivery of graduate student…

  17. Cesarean delivery technique: evidence or tradition? A review of the evidence-based cesarean delivery.

    Science.gov (United States)

    Encarnacion, Betsy; Zlatnik, Marya G

    2012-08-01

    Cesarean delivery is the most common surgical procedure performed in the United States, yet the techniques used during this procedure often vary significantly among providers. The purpose of this review was to evaluate and outline current evidence behind the cesarean delivery technique. A search of the PubMed database was conducted using the terms cesarean section and cesarean delivery and the technique of interest, for example, cesarean section prophylactic antibiotics. Few aspects of the cesarean delivery were found to have high-quality consistent evidence to support use of a particular technique. Because many aspects of the procedure are based on limited or no data, more studies on specific cesarean delivery techniques are clearly needed. Providers should be aware of which components of the cesarean delivery are evidence-based versus not when performing this procedure.

  18. The purpose of adaptation.

    Science.gov (United States)

    Gardner, Andy

    2017-10-06

    A central feature of Darwin's theory of natural selection is that it explains the purpose of biological adaptation. Here, I: emphasize the scientific importance of understanding what adaptations are for, in terms of facilitating the derivation of empirically testable predictions; discuss the population genetical basis for Darwin's theory of the purpose of adaptation, with reference to Fisher's 'fundamental theorem of natural selection'; and show that a deeper understanding of the purpose of adaptation is achieved in the context of social evolution, with reference to inclusive fitness and superorganisms.

  19. Effect of induction-delivery and uterine-delivery on apgar scoring of the newborn.

    Directory of Open Access Journals (Sweden)

    Kamat S

    1991-07-01

    Full Text Available Very short or prolonged induction-delivery interval (i.e. less than 5 minutes or more than 15 minutes and uterine-delivery interval of more than 90 seconds has a definite effect on the apgar scoring of a newborn especially when general anaesthesia is administered as compared to regional anaesthesia for caesarean section.

  20. The Special Purpose Vehicle

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2013-01-01

    The purpose of this article is to investigate whether the situation where two companies appear as originators or sponsors behind a Special Purpose Vehicle (SPV) can be described as a merger, although on micro scale. Are the underlying grounds behind the creation of an SPV much different than thos...... in a merger situation? What is actually happening when two enterprises originate an SPV? And what distinguishes an SPV from a joint venture, or is it the same thing?...

  1. 5 CFR 841.1001 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION State Income Tax Withholding § 841.1001 Purpose. This subpart regulates state income tax withholding from payments of basic benefits under the Federal Employees Retirement System (FERS)....

  2. 42 CFR 130.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... RELIEF FUND PROGRAM General Provisions § 130.1 Purpose. This part establishes criteria and procedures for... human immunodeficiency virus (HIV) due to contaminated antihemophilic factor within a specified...

  3. 33 CFR 142.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH General § 142.1 Purpose. This part is intended to promote workplace safety and health by establishing requirements relating to personnel, workplace activities and...

  4. 5 CFR 9701.301 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... MANAGEMENT SYSTEM Pay and Pay Administration General § 9701.301 Purpose. (a) This subpart contains... link pay to employees' performance ratings are designed to promote a high-performance culture...

  5. 12 CFR 1710.1 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... AND SOUNDNESS CORPORATE GOVERNANCE General § 1710.1 Purpose. OFHEO is responsible under the Federal... minimum standards with respect to the corporate governance practices and procedures of the Enterprises....

  6. Performance Analysis of Cyber Security Awareness Delivery Methods

    Science.gov (United States)

    Abawajy, Jemal; Kim, Tai-Hoon

    In order to decrease information security threats caused by human-related vulnerabilities, an increased concentration on information security awareness and training is necessary. There are numerous information security awareness training delivery methods. The purpose of this study was to determine what delivery method is most successful in providing security awareness training. We conducted security awareness training using various delivery methods such as text based, game based and a short video presentation with the aim of determining user preference delivery methods. Our study suggests that a combined delvery methods are better than individual secrity awareness delivery method.

  7. Assisted Vaginal Delivery

    Science.gov (United States)

    ... be needed. What are the risks for my baby if I have assisted vaginal delivery? Although the overall rate of injury to the baby as a result of assisted vaginal delivery is low, there still is a risk of ...

  8. eDelivery

    Data.gov (United States)

    US Agency for International Development — eDelivery provides the electronic packaging and delivery of closed and complete OPM investigation files to government agencies, including USAID, in a secure manner....

  9. 45 CFR 9.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Purpose. 9.1 Section 9.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION USE OF HHS RESEARCH FACILITIES BY ACADEMIC SCIENTISTS, ENGINEERS, AND STUDENTS § 9.1 Purpose. To enhance the availability of DHHS scientific research and study facilities to academic...

  10. 44 CFR 351.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 351.1 Section 351.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS RADIOLOGICAL EMERGENCY PLANNING AND PREPAREDNESS General § 351.1 Purpose. This part sets...

  11. 10 CFR 76.1 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... Paducah Gaseous Diffusion Plants located in Piketon, Ohio, and Paducah, Kentucky, respectively, that are... 10 Energy 2 2010-01-01 2010-01-01 false Purpose. 76.1 Section 76.1 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.1 Purpose. (a)...

  12. 47 CFR 68.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... EQUIPMENT TO THE TELEPHONE NETWORK General § 68.1 Purpose. The purpose of the rules and regulations in this part is to provide for uniform standards for the protection of the telephone network from harms caused... telephone network. (47 U.S.C. 151, 154(i), 154(j), 201-205, 218, 220, 313, 403, 412, and 5 U.S.C. 553)...

  13. Efeitos de testes de leitura sobre a generalização em crianças em processo de alfabetização The purposes of reading tests over generalization in teaching of reading to children

    Directory of Open Access Journals (Sweden)

    José Gonçalves Medeiros

    2002-01-01

    Full Text Available O presente estudo, de aquisição de leitura e escrita e fundamentado nos estudos de equivalência de estímulos, foi realizado com 7 crianças entre 7 e 16 anos, em processo de alfabetização, visando a investigação dos efeitos de testes de leitura, apresentados durante as etapas de um procedimento de escolha de acordo com o modelo. Dois conjuntos de testes de leitura foram apresentados durante as etapas dos pré e pós-testes e da aprendizagem. Todos os participantes aprenderam as palavras ensinadas, porém, apenas 4 deles generalizaram. Os testes de leitura não produziram generalização diferencial entre os grupos. Tendo por referência uma análise funcional e estrutural das palavras utilizadas, os acertos são discutidos com base nos efeitos da recombinação silábica e da contigüidade temporal entre tentativas reforçadas e não reforçadas; os erros são atribuídos à natureza abstrata das palavras de generalização, propondo-se, para os testes, o uso de palavras do cotidiano dos participantes.The present study aimed at investigating reading and writing acquisition, based on studies on stimulus equivalence. It was carried out with 7 children ranging from 7 to 16 years old, during literacy development, with the specific objective of investigating the effects of reading tests presented during the phases of a matching procedure. Two sets of reading tests were used during the phases of pre and post-tests and of learning. All participants involved in the research learned the taught words, although only 4 were able to generalize them. The reading tests did not produce differential generalization within the groups. Based on a functional and structural analysis of the words used, the successes are discussed taking into account the effects of the syllabic recombination and of the temporal contiguity with reinforced and non-reinforced attempts; the errors are attributed to the abstract nature of the generalization words, suggesting, for

  14. PENETRATION ENHANCERS: A NOVEL STRATEGY FOR ENHANCING TRANSDERMAL DRUG DELIVERY

    Directory of Open Access Journals (Sweden)

    Singla Vikas

    2011-12-01

    Full Text Available Skin penetration enhancers have been used to improve bioavailability and increase the range of drugs to be administered by topical and transdermal route. Enhancement in skin penetration via modification of the stratum corneum by hydration, or via use of chemical enhancers acting on the structure of the stratum corneum lipids and keratin, partitioning and solubility effects. The mechanism of action of penetration enhancers are used as an aid in potential clinical applications. Synthetic chemicals generally used for this purposes are rapidly losing their value in transdermal patches due to reports of their absorption into the systemic circulation and subsequent possible toxic effect upon long term application. Terpenes are included in the list of Generally Recognized as Safe (GRAS substances and have low irritancy potential. In this review, we have discussed the chemical penetration as well as natural penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.

  15. Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen

    DEFF Research Database (Denmark)

    Jain, Amit K; Thanki, Kaushik; Jain, Sanyog

    2014-01-01

    PURPOSE: The present work reports rationalized development and characterization of solidified self-nanoemulsifying drug delivery system for oral delivery of combinatorial (tamoxifen and quercetin) therapeutic regimen. METHODS: Suitable oil for the preparation of liquid SNEDDS was selected based o...

  16. Assisted delivery with forceps

    Science.gov (United States)

    ... technique your doctor may use to deliver the baby is called vacuum assisted delivery . When is a Forceps Delivery Needed? Even after ... Problems with urinating or moving your bowels after delivery For the baby, the risks are: Bumps, bruises or marks on ...

  17. Drug delivery's quest for polymers: Where are the frontiers?

    Science.gov (United States)

    Merkle, Hans P

    2015-11-01

    Since the legendary 1964 article of Folkman and Long entitled "The use of silicone rubber as a carrier for prolonged drug therapy" the role of polymers in controlled drug delivery has come a long way. Today it is evident that polymers play a crucial if not the prime role in this field. The latest boost owes to the interest in drug delivery for the purpose of tissue engineering in regenerative medicine. The focus of this commentary is on a selection of general and personal observations that are characteristic for the current state of polymer therapeutics and carriers. It briefly highlights selected examples for the long march of synthetic polymer-drug conjugates from bench to bedside, comments on the ambivalence of selected polymers as inert excipients versus biological response modifiers, and on the yet unsolved dilemma of cationic polymers for the delivery of nucleic acid therapeutics. Further subjects are the complex design of multifunctional polymeric carriers including recent concepts towards functional supramolecular polymers, as well as observations on stimuli-sensitive polymers and the currently ongoing trend towards natural and naturally-derived biopolymers. The final topic is the discovery and early development of a novel type of biodegradable polyesters for parenteral use. Altogether, it is not the basic and applied research in polymer therapeutics and carriers, but the translational process that is the key hurdle to proceed towards an authoritative approval of new polymer therapeutics and carriers.

  18. GESTATIONAL OBESITY AS A DETERMINANT OF GENERAL ANESTHESIA TECHNIQUE FOR CAESAREAN DELIVERY: A CASE REPORT Obesidad en la gestación como determinante de técnica anestésica general para cesárea: reporte de caso

    Directory of Open Access Journals (Sweden)

    José Ricardo Navarro-Vargas

    2009-01-01

    Full Text Available Background. The incidence of obesity has undergone a dramatic increase around the world during the last few years. Such epidemic behavior has been associated with obstetric patient’s frequent presentation of different stages of obesity when undergoing anesthetic procedure. Obesity in pregnant women involves the risk of adverse maternal and fetal outcomes. Hypertension and preeclampsia, diabetes, fetal macrosomia, caesarean delivery, difficult airway management and neuroaxial techniques are more likely to be performed in this group of patients. Materials and methods. This is a case report of a morbid obese patient scheduled for caesarean delivery and tubal ligation. Regional, spinal and epidural techniques were attempted for surgery with unsuccessful results; this entails general anesthesia for surgery. The literature on complications due to obesity during pregnancy was reviewed, emphasising relevance for the anesthesiologist. Conclusion.Obesity, especially morbid obesity in pregnant women, represents a challenge for anesthesia management. Updated knowledge of physiology and the conditions related to obesity in pregnancy is necessary; medical services must be prepared to provide optimum and safe obstetric anesthesia, analgesia and post-operation care.Antecedentes. La incidencia de obesidad ha tenido un incremento importante en los últimos años a nivel global. Este comportamiento epidémico ha llevado a la presentación cada vez más frecuente de pacientes obstétricas con diversos grados de obesidad para procedimientos anestésicos. La obesidad en la paciente gestante tiene asociación con desenlaces adversos maternos y fetales, incremento en el riesgo de hipertensión y trastornos hipertensivos, diabetes, macrosomía fetal, nacimiento por cesárea, además de dificultad para realizar técnicas neuroaxiales y para el manejo de la vía aérea. Material y métodos.Este es un reporte de caso de una paciente obesa extrema programada para ces

  19. Meaningful and Purposeful Practice

    Science.gov (United States)

    Clementi, Donna

    2014-01-01

    This article describes a graphic, designed by Clementi and Terrill, the authors of "Keys to Planning for Learning" (2013), visually representing the components that contribute to meaningful and purposeful practice in learning a world language, practice that leads to greater proficiency. The entire graphic is centered around the letter…

  20. 10 CFR 1021.100 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... provisions of NEPA (40 CFR parts 1500-1508). This part supplements, and is to be used in conjunction with... 10 Energy 4 2010-01-01 2010-01-01 false Purpose. 1021.100 Section 1021.100 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING PROCEDURES General §...

  1. 16 CFR 1021.1 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... decision-making process; and for preparation of environmental impact statements for major actions... Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ENVIRONMENTAL REVIEW General § 1021.1 Purpose. This part contains Consumer Product Safety Commission procedures for review of environmental effects...

  2. 45 CFR 95.501 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Purpose. 95.501 Section 95.501 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GENERAL ADMINISTRATION-GRANT PROGRAMS (PUBLIC ASSISTANCE, MEDICAL ASSISTANCE AND STATE CHILDREN'S HEALTH INSURANCE PROGRAMS) Cost Allocation Plans § 95.501...

  3. Frequency, purpose and Application

    African Journals Online (AJOL)

    User

    Teaching English in Bahir Dar General Elementary Schools. Abiy Yigzaw ... teachers' classroom practice disclosed over-use of Amharic. Finally, it was ... rejection of the cross-lingual strategy has from time to time been .... At primary school.

  4. Colloidal drug delivery systems in vaccine delivery.

    Science.gov (United States)

    Beg, Sarwar; Samad, Abdus; Nazish, Iram; Sultana, Ruksar; Rahman, Mahfoozur; Ahmad, Md Zaki; Akbar, Md

    2013-01-01

    Vaccines play a vital role in the field of community medicine to combat against several diseases of human existence. Vaccines primarily trigger the acquired immune system to develop long-lasting immunity against pathogens. Conventional approaches for vaccine delivery lacks potential to target a particular antigen to develop acquired immunity by specific antibodies. Recent advancements in vaccine delivery showed that inclusion of adjuvants in vaccine formulations or delivery of them in a carrier helps in achieving desired targeting ability, reducing the immunogenicity and significant augmentation in the immune response. Colloidal carriers (liposomes, niosomes, microspheres, proteosomes, virosomes and virus like particles (VLPs), antigen cochleates, dendrimers and carbon nanotubes) have been widely explored for vaccine delivery. Further, surface engineering of these carriers with ligands, functional moieties and monoclonal antibodies tend to enhance the immune recognition potential of vaccines by differentiation of antigen specific memory T-cells. The current review, therefore, provides an updated account on the recent advancements in various colloidal delivery systems in vaccine delivery, outlining the mechanism of immune response initiated by them along with potential applications and marketed instances in an explicit manner.

  5. Advanced drug delivery systems: Nanotechnology of health design A review

    OpenAIRE

    Javad Safari; Zohre Zarnegar

    2014-01-01

    Nanotechnology has finally and firmly entered the realm of drug delivery. Performances of intelligent drug delivery systems are continuously improved with the purpose to maximize therapeutic activity and to minimize undesirable side-effects. This review describes the advanced drug delivery systems based on micelles, polymeric nanoparticles, and dendrimers. Polymeric carbon nanotubes and many others demonstrate a broad variety of useful properties. This review emphasizes the main requirements ...

  6. Purposeful engineering economics

    CERN Document Server

    Chadderton, Ronald A

    2015-01-01

    This textbook/course supplement stands as a unique and highly original complement to the traditional engineering economics curriculum. Its primarily narrative approach conveys the essence of an “Austrian" economic perspective on cash flow analysis and decision making in engineering, without extensive tables and graphs, and requires very little mathematics. The book’s objective is to add a new perspective to the usual study of cash flow analysis and solely econometric engineering decision making. The author draws on the methodology of the Austrian Economists—a school of economic thought that bases its study of economic phenomena on the interpretation and analysis of the purposeful actions of individuals. The book includes an array of illustrative case studies examined in detail by the author and emphasizes the importance of market processes and price signals to coordinate engineering plans. Purposeful Engineering Economics is an ideal resource for students, teaching faculty, and practicing professional ...

  7. The purpose of philosophy

    Directory of Open Access Journals (Sweden)

    José Gabriel Cristancho Altuzarra

    2010-06-01

    Full Text Available It is vital to ask what to teach in philosophy and how, but to address this question, we must first determine with what purpose to do it, but above all, to know what isthe purpose of philosophy. Perhaps by determining the essential basis it would be clearer to answer the question of teaching and learning, even more, all this will help to clarify the mission of the philosophy and the philosopher today. To resolve this ponder is a philosophical reflection on traditional academic practices. Then, from some authors, it is made a dissertation on what is philosophy, to deduce in which aspects of the current academic practices is present or distant the philosophy. Finally we propose some perspectives to extend the philosophy and teaching of philosophy.

  8. Vitalism, purpose and superstition.

    Science.gov (United States)

    Lindeman, Marjaana; Saher, Marieke

    2007-02-01

    Developmental studies have shown that children assign purpose to objects more liberally than adults, and that they explain biological processes in terms of vitalistic causality. This study tested the hypothesis that similar misconceptions can be found among superstitious adults. The results from 116 superstitious and 123 sceptical individuals showed that more than sceptics, superstitious individuals attributed purpose to objects, and explained biological processes in terms of organ intentionality and energy transmission. In addition, they thought of energy as a vital force, attributing life and mental properties to it. These conceptual confusions were positively associated to all types of superstitions as well as belief in alternative medicine. The results support the argument that category mistakes and ontological confusions underlie superstitious and vitalistic thinking.

  9. Fractional CO(2) laser-assisted drug delivery

    DEFF Research Database (Denmark)

    Haedersdal, Merete; Sakamoto, Fernanda H; Farinelli, William A

    2010-01-01

    Ablative fractional resurfacing (AFR) creates vertical channels that might assist the delivery of topically applied drugs into skin. The purpose of this study was to evaluate drug delivery by CO(2) laser AFR using methyl 5-aminolevulinate (MAL), a porphyrin precursor, as a test drug....

  10. Making Decisions about Service Delivery in Early Childhood Programs

    Science.gov (United States)

    Case-Smith, Jane; Holland, Terri

    2009-01-01

    Purpose: This article presents a rationale for specialized services personnel to use fluid models of service delivery and explains how specialized services personnel make decisions about the blend of service delivery methods that will best serve a child. Method: The literature on occupational therapy, physical therapy, and speech-language…

  11. Image-guided drug delivery: preclinical applications and clinical translation

    NARCIS (Netherlands)

    Ojha, Tarun; Rizzo, Larissa; Storm, Gert; Kiessling, Fabian; Lammers, Twan

    2015-01-01

    Image-guided drug delivery refers to the combination of drug targeting and imaging. Preclinically, image-guided drug delivery can be used for several different purposes, including for monitoring biodistribution, target site accumulation, off-target localization, drug release and drug efficacy. Clini

  12. Image-guided drug delivery : Preclinical applications and clinical translation

    NARCIS (Netherlands)

    Ojha, Tarun; Rizzo, Larissa; Storm, G; Kiessling, Fabian; Lammers, Twan

    2015-01-01

    Image-guided drug delivery refers to the combination of drug targeting and imaging. Preclinically, image-guided drug delivery can be used for several different purposes, including for monitoring biodistribution, target site accumulation, off-target localization, drug release and drug efficacy. Clini

  13. Fractional CO(2) laser-assisted drug delivery

    DEFF Research Database (Denmark)

    Haedersdal, Merete; Sakamoto, Fernanda H; Farinelli, William A

    2010-01-01

    Ablative fractional resurfacing (AFR) creates vertical channels that might assist the delivery of topically applied drugs into skin. The purpose of this study was to evaluate drug delivery by CO(2) laser AFR using methyl 5-aminolevulinate (MAL), a porphyrin precursor, as a test drug....

  14. Weibull Distributions for the Preterm Delivery

    Directory of Open Access Journals (Sweden)

    Kavitha, N

    2014-06-01

    Full Text Available The purposes of this study are to evaluate the levels of CRH at pregnancy by using Weibull distributions. Also this study found the rate of change in placental CRH and the level of maternal cortisol in preterm delivery by the mathematical formulas.

  15. Development of Chitosan Acetate Films for Transdermal Delivery of ...

    African Journals Online (AJOL)

    Erah

    India. Abstract. Purpose: To formulate and evaluate chitosan acetate films designed for transdermal delivery of ... been found to have antibacterial activity and can be used as such, .... blotted with filter paper and weighed on a digital balance.

  16. Interlinking Service Delivery Innovation And Service Quality: A Conceptual Framework

    National Research Council Canada - National Science Library

    Arif Mohammad Arshad; Qin Su

    2015-01-01

      The purpose of writing this paper is to present the relationship between service delivery innovation and service quality in service organizations and to establish a research conceptual framework about this relationship...

  17. Multi purpose research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Raina, V.K. [Research Reactor Design and Projects Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)]. E-mail: vkrain@magnum.barc.ernet.in; Sasidharan, K. [Research Reactor Design and Projects Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Sengupta, Samiran [Research Reactor Design and Projects Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Singh, Tej [Research Reactor Services Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2006-04-15

    At present Dhruva and Cirus reactors provide the majority of research reactor based facilities to cater to the various needs of a vast pool of researchers in the field of material sciences, physics, chemistry, bio sciences, research and development work for nuclear power plants and production of radio isotopes. With a view to further consolidate and expand the scope of research and development in nuclear and allied sciences, a new 20 MWt multi purpose research reactor is being designed. This paper describes some of the design features and safety aspects of this reactor.

  18. Project delivery system (PDS)

    CERN Document Server

    2001-01-01

    As business environments become increasingly competitive, companies seek more comprehensive solutions to the delivery of their projects. "Project Delivery System: Fourth Edition" describes the process-driven project delivery systems which incorporates the best practices from Total Quality and is aligned with the Project Management Institute and ISO Quality Standards is the means by which projects are consistently and efficiently planned, executed and completed to the satisfaction of clients and customers.

  19. Cesarean Delivery in Adolescents.

    Science.gov (United States)

    Katz Eriksen, Jennifer L; Melamed, Alexander; Clapp, Mark A; Little, Sarah E; Zera, Chloe

    2016-10-01

    To examine the effect of maternal age on indication for primary cesarean delivery in low-risk nulliparous women. Retrospective cohort study. Urban academic tertiary care center. Nulliparous women younger than 35 years of age delivering vertex-presenting singletons at term. Participants underwent spontaneous, operative or cesarean delivery. Mode of delivery, indication, and timing of cesarean delivery. Adolescents were half as likely to undergo cesarean delivery overall (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.43-0.54), and more than one-third less likely to undergo cesarean delivery in labor (OR, 0.59; 95% CI, 0.53-0.66). Adjustment for potential confounders did not alter the strength of these associations. Adolescents were half as likely to undergo cesarean delivery for failure to progress (OR, 0.49; 95% CI, 0.43-0.54). There was no difference in the odds of cesarean delivery for nonreassuring fetal status (OR, 0.91; 95% CI, 0.77-1.06), or genital herpes (OR, 1.44; 95% CI, 0.57-3.68). Induction, macrosomia, oxytocin augmentation, and any labor complication were all associated with increased risk of cesarean delivery. There was no difference in the duration of second stage for adolescents who delivered by cesarean delivery compared with adults (240.0 vs 237.7 minutes; P = .84), but adolescents who delivered vaginally had a second stage that was one-third shorter than adults (62.5 vs 100.3 minutes; P cesarean delivery overall, and 40% less likely to undergo a primary cesarean delivery in labor, even after adjustment for multiple maternal, neonatal, and labor characteristics. This difference is not explained by differences in the duration of the second stage of labor. Copyright © 2016 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  20. Buccal drug delivery.

    Science.gov (United States)

    Smart, John D

    2005-05-01

    Buccal formulations have been developed to allow prolonged localised therapy and enhanced systemic delivery. The buccal mucosa, however, while avoiding first-pass effects, is a formidable barrier to drug absorption, especially for biopharmaceutical products (proteins and oligonucleotides) arising from the recent advances in genomics and proteomics. The buccal route is typically used for extended drug delivery, so formulations that can be attached to the buccal mucosa are favoured. The bioadhesive polymers used in buccal drug delivery to retain a formulation are typically hydrophilic macro-molecules containing numerous hydrogen bonding groups. Newer second-generation bioadhesives have been developed and these include modified or new polymers that allow enhanced adhesion and/or drug delivery, in addition to site-specific ligands such as lectins. Over the last 20 years a wide range of formulations has been developed for buccal drug delivery (tablet, patch, liquids and semisolids) but comparatively few have found their way onto the market. Currently, this route is restricted to the delivery of a limited number of small lipophilic molecules that readily cross the buccal mucosa. However, this route could become a significant means for the delivery of a range of active agents in the coming years, if the barriers to buccal drug delivery are overcome. In particular, patient acceptability and the successful systemic delivery of large molecules (proteins, oligonucleotides and polysaccharides) via this route remains both a significant opportunity and challenge, and new/improved technologies may be required to address these.

  1. 7 CFR 271.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ..., in part: Congress hereby finds that the limited food purchasing power of low-income households... households to obtain a more nutritious diet through normal channels of trade by increasing food purchasing power for all eligible households who apply for participation. (b) Scope of the regulations. Part 271...

  2. [General-purpose microcomputer for medical laboratory instruments].

    Science.gov (United States)

    Vil'ner, G A; Dudareva, I E; Kurochkin, V E; Opalev, A A; Polek, A M

    1984-01-01

    Presented in the paper is the microcomputer based on the KP580 microprocessor set. Debugging of the hardware and the software by using the unique debugging stand developed on the basis of microcomputer "Electronica-60" is discussed.

  3. DYNSYL: a general-purpose dynamic simulator for chemical processes

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, G.K.; Rozsa, R.B.

    1978-09-05

    Lawrence Livermore Laboratory is conducting a safeguards program for the Nuclear Regulatory Commission. The goal of the Material Control Project of this program is to evaluate material control and accounting (MCA) methods in plants that handle special nuclear material (SNM). To this end we designed and implemented the dynamic chemical plant simulation program DYNSYL. This program can be used to generate process data or to provide estimates of process performance; it simulates both steady-state and dynamic behavior. The MCA methods that may have to be evaluated range from sophisticated on-line material trackers such as Kalman filter estimators, to relatively simple material balance procedures. This report describes the overall structure of DYNSYL and includes some example problems. The code is still in the experimental stage and revision is continuing.

  4. Building a General Purpose Beowulf Cluster for Astrophysics Research

    Science.gov (United States)

    Phelps, M. W. L.

    2005-12-01

    The challenges of designing and deploying a high performance, Linux based, Beowulf cluster for use by many departments and projects are covered. Considerations include hardware, infrastructure (space, cooling, networking, etc.), and software; particularly scheduling systems.

  5. A general purpose characterization system for rooftop hybrid microconcentrators

    Science.gov (United States)

    Middleton, Robert; Jones, Christopher; Thomsen, Elizabeth; Diez, Vicente Munoz; Harvey, J.; Everett, Vernie; Blakers, Andrew

    2014-09-01

    A versatile characterization system for hybrid thermal and photovoltaic solar receivers is presented and demonstrated. The characterization of the thermal loss and effective area of a novel hybrid receiver is presented.

  6. GPMIMD2: General Purpose Multiple Instruction Multiple Data Machines 2

    CERN Document Server

    TexLab Media production

    1996-01-01

    An initiative within the European ESPRIT III Programme. Demonstration of a European scalable parallel supercomputer in production environments. A scalable parallel computer based on European High Performance Computing (HPC) technology has been installed in the CERN Computer Centre since July 1994. The initiative to support this development came from the European Union's (EU) Esprit Programme (European Strategic Programme for Research and Development in Information Technology). CERN was the lead partner and co-ordinator of this project. Other partners were: CERFACS, Meiko, Parsys, Telmat Multinode, and Alenia Spazio / QSW. The GPMIMD2 project started in March 1993 and terminated at the end of August 1996.

  7. General Reevaluation Supporting Documentation for Flood Control and Related Purposes.

    Science.gov (United States)

    1984-11-01

    1,16C Local at Wahpeton 1,020 -- 1,020 -- 1,020 Ottertail below Orwell 245 -- 245 1,585 1,830 Wild Rice at Abercrombie, ND 1,370 120 1,490 590...addition, the Corps maintains stations at Baldhill Dam, Lake Traverse, Orwell Dam, and Red Lake Dam, wnile the National Weather Service maintains many... George your investment interest earn- The major reason for the ex- Wogaman. 5th Ward; Mayor rags are in keeping with the cons of expenditures an the

  8. GPUs: An Emerging Platform for General-Purpose Computation

    Science.gov (United States)

    2007-08-01

    generations from NVIDIA and ATI (the major players in this part of the market ) are expected to support 64-bit floating- point precision (9, 10). The...get the answer as a 1x1 array float_pi = Pi.read_scalar(); // convert answer to a simple float printf(“Value of Pi = %f\

  9. 7 CFR 1485.10 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... the Market Access Program (MAP), and a subcomponent of that program, the Export Incentive Program... develop, maintain or expand commercial export markets for U.S. agricultural commodities and products. MAP... one entity gains an undue advantage. The MAP and EIP/MAP are administered by personnel of the...

  10. 7 CFR 227.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... carry out a nutrition information and education program through a system of grants to State agencies to provide for (a) the nutritional training of educational and foodservice personnel, (b) the...

  11. General Purpose Data-Driven System Monitoring for Space Operations

    Data.gov (United States)

    National Aeronautics and Space Administration — Modern space propulsion and exploration system designs are becoming increasingly sophisticated and complex. Determining the health state of these systems using...

  12. 7 CFR 250.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Supplemental Food Program, the Special Supplemental Nutrition Program for Women, Infants, and Children, the... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... Department by Federal, State and private agencies for use in any State in child nutrition programs,...

  13. 7 CFR 246.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS AND CHILDREN... Agriculture shall carry out the Special Supplemental Nutrition Program for Women, Infants and Children...

  14. Large General Purpose Frame for Studying Force Vectors

    Science.gov (United States)

    Heid, Christy; Rampolla, Donald

    2011-01-01

    Many illustrations and problems on the vector nature of forces have weights and forces in a vertical plane. One of the common devices for studying the vector nature of forces is a horizontal "force table," in which forces are produced by weights hanging vertically and transmitted to cords in a horizontal plane. Because some students have…

  15. ArrayD: A general purpose software for Microarray design

    Directory of Open Access Journals (Sweden)

    Sharma Vineet K

    2004-10-01

    Full Text Available Abstract Background Microarray is a high-throughput technology to study expression of thousands of genes in parallel. A critical aspect of microarray production is the design aimed at space optimization while maximizing the number of gene probes and their replicates to be spotted. Results We have developed a software called 'ArrayD' that offers various alternative design solutions for an array given a set of user requirements. The user feeds the following inputs: type of source plates to be used, number of gene probes to be printed, number of replicates and number of pins to be used for printing. The solutions are stored in a text file. The choice of a design solution to be used will be governed by the spotting chemistry to be used and the accuracy of the robot. Conclusions ArrayD is a software for standard cartesian robots. The software aids users in preparing a judicious and elegant design. ArrayD is universally applicable and is available at http://www.igib.res.in/scientists/arrayd/arrayd.html.

  16. PROSOFT: a general purpose software in protein chemistry.

    Science.gov (United States)

    Petrilli, P

    1988-04-01

    Applesoft and 6502 Assembler software was designed to quickly perform operations commonly encountered in protein chemistry. It was not designed for a specific application but can be conveniently used to speed up the determination of protein primary structure.

  17. standalone general purpose data logger design and implementation ...

    African Journals Online (AJOL)

    eobe

    The circuit takes an input range of 15 – 30V DC in addition. 30V DC in addition. 30V DC in addition; an in-built. 9V rechargeable battery provides backup power in the absence of an external ..... chip has a size of 256 Kbits, which is equal to:.

  18. Managing RFID Sensors Networks with a General Purpose RFID Middleware

    Science.gov (United States)

    Abad, Ismael; Cerrada, Carlos; Cerrada, Jose A.; Heradio, Rubén; Valero, Enrique

    2012-01-01

    RFID middleware is anticipated to one of the main research areas in the field of RFID applications in the near future. The Data EPC Acquisition System (DEPCAS) is an original proposal designed by our group to transfer and apply fundamental ideas from System and Data Acquisition (SCADA) systems into the areas of RFID acquisition, processing and distribution systems. In this paper we focus on how to organize and manage generic RFID sensors (edge readers, readers, PLCs, etc…) inside the DEPCAS middleware. We denote by RFID Sensors Networks Management (RSNM) this part of DEPCAS, which is built on top of two new concepts introduced and developed in this work: MARC (Minimum Access Reader Command) and RRTL (RFID Reader Topology Language). MARC is an abstraction layer used to hide heterogeneous devices inside a homogeneous acquisition network. RRTL is a language to define RFID Reader networks and to describe the relationship between them (concentrator, peer to peer, master/submaster). PMID:22969370

  19. General purpose photoneutron production in MCNP4A

    Energy Technology Data Exchange (ETDEWEB)

    Gallmeier, F.X.

    1995-08-01

    A photoneutron production option was implemented in the MCNP4A code, mainly to supply a tool for reactor shielding calculations in beryllium and heavy water environments of complicated three-dimensional geometries. Photoneutron production cross sections for deuterium and beryllium were created. Subroutines were developed to calculate the probability of photoneutron production at photon collision sites and the energy and flight direction of the created photoneutrons. These subroutines were implemented into MCNP4A. Some small program changes were necessary for processing the input to read the photoneutron production cross sections and to install a photoneutron switch. Some arrays were installed or extended to sample photoneutron creation and loss information, and output routines were changed to give the appropriate summary tables. To verify and validate the photoneutron production data and the MCNP4A implementations, the yields of photoneutron sources were calculated and compared with experiments. In the case of deuterium-based photoneutron sources, the calculations agreed well with the experiments; the beryuium-based photoneutron source calculations were up to 30% higher compared with the measurements. More accurate beryllium photoneutron cross sections would be desirable. To apply the developed method to a real shielding problem, the fast neutron fluxes in the heavy-water-filled reflector vessel of the Advanced Neutron Source reactor were investigated and compared with published DORT calculations. Considering the complete independence between the calculations, the merely 10 to 20% lower fluxes obtained with MCNP4A, compared against the DORT results, were more than satisfactory, as the discrepancy is based primarily on differences in the calculated thermal neutron fluxes.

  20. 33 CFR 332.1 - Purpose and general considerations.

    Science.gov (United States)

    2010-07-01

    ...) Guidelines at 40 CFR part 230. (2) Pursuant to these requirements, the district engineer will issue an... available and capable of being done after taking into consideration cost, existing technology, and logistics...

  1. 40 CFR 230.91 - Purpose and general considerations.

    Science.gov (United States)

    2010-07-01

    ... these requirements, the district engineer will issue an individual section 404 permit only upon a... done after taking into consideration cost, existing technology, and logistics in light of overall...

  2. Evaluation of the NASTRAN General Purpose Computer Program.

    Science.gov (United States)

    1980-08-01

    element, the bending behavior using the quintic transverse displacement TRPLT1 element, and membrane-bending coupling using Novozhilov shallow - shell theory . This...of shallow shell theory . 7.3.3. Evaluation Results Although Narayanaswami presented two numerical examples (spherical cap, Scordelis-Lo cylindrical

  3. Managing RFID Sensors Networks with a General Purpose RFID Middleware

    Directory of Open Access Journals (Sweden)

    Enrique Valero

    2012-06-01

    Full Text Available RFID middleware is anticipated to one of the main research areas in the field of RFID applications in the near future. The Data EPC Acquisition System (DEPCAS is an original proposal designed by our group to transfer and apply fundamental ideas from System and Data Acquisition (SCADA systems into the areas of RFID acquisition, processing and distribution systems. In this paper we focus on how to organize and manage generic RFID sensors (edge readers, readers, PLCs, etc… inside the DEPCAS middleware. We denote by RFID Sensors Networks Management (RSNM this part of DEPCAS, which is built on top of two new concepts introduced and developed in this work: MARC (Minimum Access Reader Command and RRTL (RFID Reader Topology Language. MARC is an abstraction layer used to hide heterogeneous devices inside a homogeneous acquisition network. RRTL is a language to define RFID Reader networks and to describe the relationship between them (concentrator, peer to peer, master/submaster.

  4. Dynamic Transparent General Purpose Process Migration for Linux

    Directory of Open Access Journals (Sweden)

    Amirreza Zarrabi

    2013-01-01

    Full Text Available Process migration refers to the act of transferring a process in the middle of its execution from one machine to another in a network. In this paper, we proposed a process migration framework for Linux OS. It is a multilayer architecture to confine every functionality independent section of the system in separate layer. This architecture is capable of supporting diverse applications due to generic user space interface and dynamic structure that can be modified according to demands.

  5. A General Purpose Digital System for Field Vibration Testing

    DEFF Research Database (Denmark)

    Brincker, Rune; Larsen, Jesper Abildgaard; Ventura, Carlos

    2007-01-01

    This paper describes the development and concept implementation of a highly sensitive digital recording system for seismic applications and vibration measurements on large Civil Engineering structures. The system is based on highly sensitive motion transducers that have been used by seismologists...... and geophysicists for decades. The conventional geophone's ratio of cost to performance, including noise, linearity and dynamic range is unmatched by advanced modern accelerometers. The unit comprises six independent sensor elements that can be used in two different configurations for noise reduction and extended...

  6. JUNO: a General Purpose Experiment for Neutrino Physics

    CERN Document Server

    Grassi, Marco

    2016-01-01

    JUNO is a 20 kt Liquid Scintillator Antineutrino Detector currently under construction in the south of China. This report reviews JUNO's physics programme related to all neutrino sources but reactor antineutrinos, namely neutrinos from supernova burst, solar neutrinos and geoneutrinos.

  7. Determining PACAF Transportation Alternatives to the General Purpose Vehicle

    Science.gov (United States)

    2005-03-01

    equipped with specified headlamps, stop lamps, turn signal lamps, reflex reflectors, parking brakes, rear view mirrors, windshields, seat belts, and...Lighting: Quartz-halogen headlamps, front and rear turn signals , high-mount rear brake and taillamps with a 20 second safety delay after vehicle is

  8. Is there any difference on the purpose of enterprise education and the general purpose of education?

    DEFF Research Database (Denmark)

    Blenker, Per

    The paper claims that two different types of inhabitants populate research on the entrepreneurship-education interface. Some are coming from entrepreneurship research – others are coming from education research. Depending on their disciplinary background they pose two different research questions...... other and contribute to each others research, a classical didactical method of thesis, anti-thesis and synthesis is used. Based on this analysis, the two central question of the enterprise–education nexus is reformulated into one new question of: “How can we provide self-directed learning that enables...

  9. Emulsomes: An emerging vesicular drug delivery system

    Directory of Open Access Journals (Sweden)

    Bhawandeep Gill

    2012-01-01

    Full Text Available The oral route is the easiest, cost effective, and most vital method for drug administration. Therefore, improvement of dosage forms mainly for the prolonged release purpose has been a challenge for scientists. Vesicular drug delivery systems are developed with a purpose to overcome problems coupled with the drugs such a poor bioavailability, protection from harsh gastric environment, and from gastric enzymes, which degrade the drug. Vesicular drug delivery systems such as liposomes, emulsions, niosomes, proniosomes, solid lipid-nano particles, ethosomes, nanoparticles, and pharmacosomes, etc have gained much attention, but emulsomes have rouse as system, which bypasses many disadvantages associated with other systems, developed as novel lipoidal vesicular system with internal solid fat core surrounded by phospholipid bilayer. This technology is designed to act as vehicle for poorly soluble drugs. The drug is enclosed in the emulsomes and provide prolong existence of drug in systemic circulation. Furthermore, emulsomal-based formulations of genetic drugs such as antisense oligonucleotides and plasmids for gene therapy that have clear potential for systemic utility are increasingly available. This review addresses the concept of emulsomal drug delivery system, summarizes the success of emulsomes for the delivery of small molecules, and special attention has been paid to its formulation design, advantages, biopharmaceutical aspects, stability aspects, and various aspects related to drug delivery including future aspects.

  10. Prediction of preterm delivery

    NARCIS (Netherlands)

    Wilms, F.F.

    2014-01-01

    Preterm delivery is in quantity and in severity an important issue in the obstetric care in the Western world. There is considerable knowledge on maternal and obstetric risk factors of preterm delivery. Of the women presenting with preterm labor, the majority is pregnant with a male fetus and in

  11. Prediction of preterm delivery

    NARCIS (Netherlands)

    Wilms, F.F.

    2014-01-01

    Preterm delivery is in quantity and in severity an important issue in the obstetric care in the Western world. There is considerable knowledge on maternal and obstetric risk factors of preterm delivery. Of the women presenting with preterm labor, the majority is pregnant with a male fetus and in Cau

  12. Delivery by Cesarean Section

    Science.gov (United States)

    ... often when: The mother has had a previous baby by Cesarean delivery The obstetrician feels that the baby’s health might ... lost time. Don’t be surprised if your baby is still affected by the anesthesia for six to twelve hours after delivery and appears a little sleepy. If you’re ...

  13. Vacuum-assisted delivery

    Science.gov (United States)

    ... a handle on the cup to move the baby through the birth canal. When is Vacuum-assisted Delivery Needed? Even after your cervix is fully dilated ( ... delivers the baby's head, you will push the baby the rest of the way out. After delivery, you can hold your baby on your tummy ...

  14. 78 FR 55731 - Notice of Service Delivery Area Designation for the Wilton Rancheria

    Science.gov (United States)

    2013-09-11

    ... HUMAN SERVICES Indian Health Service Notice of Service Delivery Area Designation for the Wilton... Indian Health Service (IHS) proposes the geographic boundaries of the Service Delivery Area (SDA) for the... Contract Health Service Delivery Area (CHSDA), for the purpose of operating a Contract Health Service...

  15. Previous prelabor or intrapartum cesarean delivery and risk of placenta previa.

    Science.gov (United States)

    Downes, Katheryne L; Hinkle, Stefanie N; Sjaarda, Lindsey A; Albert, Paul S; Grantz, Katherine L

    2015-05-01

    The purpose of this study was to examine the association between previous cesarean delivery and subsequent placenta previa while distinguishing cesarean delivery before the onset of labor from intrapartum cesarean delivery. We conducted a retrospective cohort study of electronic medical records from 20 Utah hospitals (2002-2010) with restriction to the first 2 singleton deliveries of nulliparous women at study entry (n=26,987). First pregnancy delivery mode was classified as (1) vaginal (reference), (2) cesarean delivery before labor onset (prelabor), or (3) cesarean delivery after labor onset (intrapartum). Risk of second delivery previa was estimated by previous delivery mode with the use of logistic regression and was adjusted for maternal age, insurance, smoking, comorbidities, previous pregnancy loss, and history of previa. Most first deliveries were vaginal (82%; n=22,142), followed by intrapartum cesarean delivery (14.6%; n=3931), or prelabor cesarean delivery (3.4%; n=914). Incidence of second delivery previa was 0.29% (n=78) and differed by previous delivery mode: vaginal, 0.24%; prelabor cesarean delivery, 0.98%; intrapartum cesarean delivery, 0.38% (Pprevia (adjusted odds ratio, 2.62; 95% confidence interval, 1.24-5.56). There was no significant association between previous intrapartum cesarean delivery and previa (adjusted odds ratio, 1.22; 95% confidence interval, 0.68-2.19). Previous prelabor cesarean delivery was associated with a >2-fold significantly increased risk of previa in the second delivery, although the approximately 20% increased risk of previa that was associated with previous intrapartum cesarean delivery was not significant. Although rare, the increased risk of placenta previa after previous prelabor cesarean delivery may be important when considering nonmedically indicated prelabor cesarean delivery. Published by Elsevier Inc.

  16. 16 CFR 1031.1 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION PARTICIPATION AND COMMISSION EMPLOYEE INVOLVEMENT IN VOLUNTARY STANDARDS ACTIVITIES General Policies § 1031.1 Purpose and scope. (a) This part 1031 sets forth the Consumer Product Safety Commission's guidelines and requirements...

  17. A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy.

    Science.gov (United States)

    Johnsen, Kasper Bendix; Gudbergsson, Johann Mar; Skov, Martin Najbjerg; Pilgaard, Linda; Moos, Torben; Duroux, Meg

    2014-08-01

    Exosomes denote a class of secreted nanoparticles defined by size, surface protein and lipid composition, and the ability to carry RNA and proteins. They are important mediators of intercellular communication and regulators of the cellular niche, and their altered characteristics in many diseases, such as cancer, suggest them to be important both for diagnostic and therapeutic purposes, prompting the idea of using exosomes as drug delivery vehicles, especially for gene therapy. This review covers the current status of evidence presented in the field of exosome-based drug delivery systems. Components for successful exosome-based drug delivery, such as choice of donor cell, therapeutic cargo, use of targeting peptide, loading method and administration route are highlighted and discussed with a general focus pertaining to the results obtained in models of different cancer types. In addition, completed and on-going clinical trials are described, evaluating exosome-based therapies for the treatment of different cancer types. Due to their endogenous origin, exosome-based drug delivery systems may have advantages in the treatment of cancer, but their design needs further refinement to justify their usage on the clinical scale.

  18. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Larsen, Marcus M.; Bharati, Pratyush

    2013-01-01

    This article examines antecedents and performance implications of global delivery models (GDMs) in global business services. GDMs require geographically distributed operations to exploit both proximity to clients and time-zone spread for efficient service delivery. We propose and empirically show...... that service providers who differentiate based on speed of service delivery are likely to set up GDM structures, and that these structures positively affect deal renewal rates if speed is important for clients in selecting vendors. Findings imply that, as co-location becomes less necessary for providing...... digitalized services, time zones increasingly affect....

  19. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Møller Larsen, Marcus; Bharati, Pratyush

    We investigate antecedents and contingencies of location configurations supporting global delivery models (GDMs) in global outsourcing. GDMs are a new form of IT-enabled client-specific investment promoting services provision integration with clients by exploiting client proximity and time......-zone spread allowing for 24/7 service delivery and access to resources. Based on comprehensive data we show that providers are likely to establish GDM configurations when clients value access to globally distributed talent pools and speed of service delivery, and in particular when services are highly...

  20. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Møller Larsen, Marcus; Bharati, Pratyush

    We investigate antecedents and contingencies of location configurations supporting global delivery models (GDMs) in global outsourcing. GDMs are a new form of IT-enabled client-specific investment promoting services provision integration with clients by exploiting client proximity and time......-zone spread allowing for 24/7 service delivery and access to resources. Based on comprehensive data we show that providers are likely to establish GDM configurations when clients value access to globally distributed talent pools and speed of service delivery, and in particular when services are highly...... commoditized. Findings imply that coordination across time zones increasingly affects international operations in business-to-business and born-global industries....

  1. Focus on Delivery

    DEFF Research Database (Denmark)

    Hasman, Kirsten; Barfoed, Anne

    2016-01-01

    (2). It is, however, not clarified which of the multifaceted aspects of preventing perineal injury that might explain the decrease (3). Aims: We hypothesized that the use of structured reflection on a clinical practice by midwives and midwifery students would increase both parts’ knowledge on how...... attended a delivery. The tool was developed based on five categories: communication, pace, ergonomic positions, perineal support in the chosen birth position and delivery of the shoulders, and five predefined questions guided an overall reflection upon practice. After a delivery a project midwife, who had...

  2. 10 CFR 626.8 - Deferrals of contractually scheduled deliveries.

    Science.gov (United States)

    2010-01-01

    ... PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.8 Deferrals of contractually scheduled deliveries. (a) General. (1) DOE prefers to take deliveries of petroleum for the SPR at times scheduled under applicable contracts. However, in the event the market is distorted by disruption to supply or other factors, DOE...

  3. 46 CFR 169.101 - Purpose.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.101 Purpose. The regulations in this part set forth uniform requirements which are suited to the particular characteristics and specialized operations of sailing school vessels as defined in Title...

  4. 5 CFR 843.101 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Purpose. 843.101 Section 843.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL... definitions and regulations that have general application throughout this part. ...

  5. 21 CFR 516.2 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... designation of minor use or minor species new animal drugs and associated exclusive marketing rights. ... AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES General Provisions § 516.2 Purpose....

  6. 10 CFR 712.1 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... HUMAN RELIABILITY PROGRAM Establishment of and Procedures for the Human Reliability Program General Provisions § 712.1 Purpose. This part establishes the policies and procedures for a Human Reliability Program...). The HRP is a security and safety reliability program designed to ensure that individuals who...

  7. 21 CFR 54.1 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... applications and reclassification petitions for medical devices. (b) The agency reviews data generated in these... DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL FINANCIAL DISCLOSURE BY CLINICAL INVESTIGATORS § 54.1 Purpose. (a) The Food and Drug Administration (FDA) evaluates clinical studies submitted...

  8. Reflections on the Purpose of Methodology Training.

    Science.gov (United States)

    Kontra, Edit H.

    1997-01-01

    Examines the purpose of the methodology course for inservice teacher training. After considering the difficulties arising when trainees' and trainers' goals differ, the article broadens its focus to cover a more general training context and presents a model allowing trainers who recommend a learner-centered approach to put their ideas into…

  9. 7 CFR 1910.51 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... GENERAL Credit Reports (Individual) § 1910.51 Purpose. This subpart prescribes the policies and procedures of the Farmers Home Administration (FmHA) or its successor agency under Public Law 103-354 for individual and joint type credit reports. Credit reports will be ordered to determine the eligibility...

  10. 34 CFR 74.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 74.1 Purpose. (a) This part establishes... education, hospitals, and other non-profit organizations. (b) The Secretary does not impose additional or... State and Local Governments. (d) Non-profit organizations that implement Federal programs for the...

  11. 5 CFR 330.1101 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... PLACEMENT (GENERAL) Federal Employment Priority Consideration Program for Displaced Employees of the District of Columbia Department of Corrections § 330.1101 Purpose. A displaced employee of the District of Columbia (DC) Department of Corrections (DOC) who is separated from his/her position as a result of...

  12. 10 CFR 74.1 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Provisions § 74.1 Purpose. (a) This part has been established to contain the requirements for the control and accounting of... control and accounting of source material at enrichment facilities are also included. (b) The...

  13. 32 CFR 169a.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES General § 169a.1 Purpose. This part: (a) Reissues DoD Instruction 4100.33 1 to update policy... § 169a.1(a). 3 Copies may be obtained if needed, from the Office of Management and Budget, Executive... and Industrial Activities Cost Comparison Handbook.” 4 See footnote 1 to § 169a.1(a)....

  14. 22 CFR 1203.735-101 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... reporting employment and financial interests. Note: These regulations are codified in State 3 FAM 620, AID... Foreign Relations UNITED STATES INTERNATIONAL DEVELOPMENT COOPERATION AGENCY EMPLOYEE RESPONSIBILITIES AND CONDUCT General Provisions § 1203.735-101 Purpose. The maintenance of the highest standards of...

  15. 18 CFR 3b.1 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Purpose. 3b.1 Section 3b.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES COLLECTION, MAINTENANCE, USE, AND DISSEMINATION OF RECORDS OF IDENTIFIABLE...

  16. FLOATING DRUG DELIVERY SYSTEM - CHRONOTHERAPEUTIC APPROACH

    Directory of Open Access Journals (Sweden)

    Vishal Kalal

    2011-04-01

    Full Text Available The purpose of writing this review on the floating drug delivery systems (FDDS was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. FDDS is one of the approaches in chronotherapeutic drug delivery. In the past reviews of FDDS the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, their classification and formulation aspects have been covered. This review summarizes the special focus on chronotherapeutics, diseases affected by biological rhythm, its importance, advantages, various approaches in Chronotherapeutic drug delivery and applications of FDDS. These systems are useful for several problems encountered during the development of a pharmaceutical dosage forms.

  17. Transdermal delivery of proteins.

    Science.gov (United States)

    Kalluri, Haripriya; Banga, Ajay K

    2011-03-01

    Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows the transport of only small lipophilic drug molecules. Enhancement techniques such as chemical enhancers, iontophoresis, microneedles, electroporation, sonophoresis, thermal ablation, laser ablation, radiofrequency ablation and noninvasive jet injectors aid in the delivery of proteins by overcoming the skin barrier in different ways. In this review, these enhancement techniques that can enable the transdermal delivery of proteins are discussed, including a discussion of mechanisms, sterility requirements, and commercial development of products. Combination of enhancement techniques may result in a synergistic effect allowing increased protein delivery and these are also discussed.

  18. Enhancement of therapeutic drug and DNA delivery into cells by electroporation* Enhancement of therapeutic drug and DNA delivery into cells by electroporation

    Science.gov (United States)

    Rabussay, Dietmar; Dev, Nagendu B.; Fewell, Jason; Smith, Louis C.; Widera, Georg; Zhang, Lei

    2003-02-01

    The effectiveness of potentially powerful therapeutics, including DNA, is often limited by their inability to permeate the cell membrane efficiently. Electroporation (EP) also referred to as `electropermeabilization' of the outer cell membrane renders this barrier temporarily permeable by inducing `pores' across the lipid bilayer. For in vivo EP, the drug or DNA is delivered into the interstitial space of the target tissue by conventional means, followed by local EP. EP pulses of micro- to millisecond duration and field strengths of 100-1500 V cm-1 generally enhance the delivery of certain chemotherapeutic drugs by three to four orders of magnitude and intracellular delivery of DNA several hundred-fold. We have used EP in clinical studies for human cancer therapy and in animals for gene therapy and DNA vaccination. Late stage squamous cell carcinomas of the head and neck were treated with intratumoural injection of bleomycin and subsequent EP. Of the 69 tumours treated, 25% disappeared completely and another 32% were reduced in volume by more than half. Residence time of bleomycin in electroporated tumours was significantly greater than in non-electroporated lesions. Histological findings and gene expression patterns after bleomycin-EP treatment indicated rapid apoptosis of the majority of tumour cells. In animals, we demonstrated the usefulness of EP for enhanced DNA delivery by achieving normalization of blood clotting times in haemophilic dogs, and by substantially increasing transgene expression in smooth muscle cells of arterial walls using a novel porous balloon EP catheter. Finally, we have found in animal experiments that the immune response to DNA vaccines can be dramatically enhanced and accelerated by EP and co-injection of micron-sized particles. We conclude that EP represents an effective, economical and safe approach to enhance the intracellular delivery, and thus potency, of important drugs and genes for therapeutic purposes. The safety and pharmaco

  19. MUCOSAL DRUG DELIVERY SYSTEM

    OpenAIRE

    Madan Jyotsana; Banode Sagar; Dangi Mahesh

    2010-01-01

    The process of mucoadhesion involving a polymeric drug delivery system is a complex one that includes processes such as wetting, adsorption and interpenetration of polymer chains. The success and degree of mucoadhesion bonding is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings. The attractiveness of mucosal-targeted controlled drug delivery of active pharmaceutical ingredients, has led formulatio...

  20. 40 CFR 1.3 - Purpose and functions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Purpose and functions. 1.3 Section 1.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.3 Purpose and functions. The U.S. Environmental Protection Agency...

  1. 28 CFR 512.10 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Purpose and scope. 512.10 Section 512.10 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION RESEARCH Research § 512.10 Purpose and scope. General provisions for the protection of human...

  2. Newborns from deliveries with epidural anaesthesia

    Directory of Open Access Journals (Sweden)

    Avramović Lidija

    2010-01-01

    Full Text Available Introduction. The use of epidural anaesthesia in delivery with the purpose to reduce pain and fear in a pregnant woman has the influence on the physiological status of the woman in childbirth and the course of delivery. From the epidural space of the pregnant woman, one part of free anaesthetic comes in the foetal circulation through the mother's circulation and placenta and connects with the foetal proteins. A lower value of albumins and serum proteins in the foetal circulation give bigger free fraction of anaesthetic which is accumulated in the foetal liver, brain and heart full of blood. Objective. The aim of the study was to examine the influence of epidural anaesthesia on the newborn. Methods. Retrospective study of 6,398 documents of newborns was performed in our Clinic of Gynaecology and Obstetrics 'Narodni front' during 2006. The first group was made of 455 newborns from deliveries with epidural anaesthesia and the second was the control group of 5,943 remaining newborns. In both groups we analysed the following: sex, week of gestation, weight, Apgar score, measure of care and resuscitation, perinatal morbidity and then the obtained results were compared. Results. Most of deliveries were vaginal without obstetric intervention (86.6%. The number of deliveries finished with vacuum extractor (4.6% was statistically significantly bigger in the group with epidural anaesthesia than in the control group. Most of the newborns in the first group were born on time (96.5% in 39.0±1.0 week of gestation and with foetal weight 3448±412 grammes. There was no statistical significance in Apgar score between both groups. Epidural anaesthesia does not increase the degree of the newborn's injury. Lower pH of blood was found in the newborns from deliveries with vacuum extractor or operated on (the Ceasarean section. Conclusion. Application of epidural anaesthesia decreases duration of delivery and has no adverse effects on the newborn and hypoxic

  3. 42 CFR 4.3 - Purpose of the Library.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Purpose of the Library. 4.3 Section 4.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS NATIONAL LIBRARY OF MEDICINE § 4.3 Purpose of the Library. The purpose of the Library is to assist the advancement of...

  4. 20 CFR 401.155 - Law enforcement purposes.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Law enforcement purposes. 401.155 Section 401... INFORMATION Disclosure of Official Records and Information § 401.155 Law enforcement purposes. (a) General. The Privacy Act allows us to disclose information for law enforcement purposes under certain...

  5. Transdermal Delivery of Nisoldipine: Refinement of Vehicles.

    Science.gov (United States)

    El Maghraby, Gamal M; Ahmed, Amal A; Osman, Mohamed A

    2015-01-01

    Nisoldipine is used for the treatment of hypertension and angina pectoris. However, it has very low bioavailabil-ty, which is attributed to extensive pre-systemic metabolism. In addition, nisol-ipine is highly potent (used at a low dose). Taking into consideration the fact that transdermal delivery avoids the pre-systemic metabolism and is only suit-ble for potent drugs, nisoldipine can be considered as an excellent candidate for transdermal delivery. Accordingly, the purpose of this study was to optimize nisoldipine transdermal delivery. That was achieved initially by investigating the effect of vehicles on skin penetration. The tested vehicles were ranked with respect to transdermal flux of nisoldipine as isopropyl myristate > oleic acid > propylene glycol > water > polyethylene glycol 400. A combination of oleic acid with propylene glycol was synergistic with a ratio of 1:2 w/w being the best. These results were taken further to develop microemulsion systems using either oleic acid or isopropyl myristate as the oil phase. Both cases employed polyoxy-thylene sorbitan monooleate as a surfactant with propylene glycol being uti-ized as a cosurfactant in the case of oleic acid and ethanol in the case of isopropyl myristate. The developed microemulsions produced significant enhancement in nisoldipine transdermal delivery with the flux being even greater than that obtained from the corresponding pure vehicles. This achieve-ent was recorded in optimum microemulsion formulations which contained a cosurfactant. The study provided stepwise optimization of a vehicle for trans-ermal delivery of nisoldipine.

  6. Developmental Purposes of Commercial Games.

    Science.gov (United States)

    Practical Pointers, 1977

    1977-01-01

    Listed are 45 table, target, manipulative, active, and creative games with such developmental purposes as associative learning, tactile discrimination, and visual motor integration. Information includes the name of the item, distributor, price, description, and developmental purpose. (JYC)

  7. Infection, antibiotics, and preterm delivery.

    Science.gov (United States)

    Locksmith, G; Duff, P

    2001-10-01

    The relationship between genital tract infection and preterm delivery has been established on the basis of biochemical, microbiological, and clinical evidence. In theory, pathogenic bacteria may ascend from the lower reproductive tract into the uterus, and the resulting inflammation leads to preterm labor, rupture of the membranes, and birth. A growing body of evidence suggests that preterm labor and/rupture of the membranes are triggered by micro-organisms in the genital tract and by the host response to these organisms, ie, elaboration of cytokines and proteolytic enzymes. Epidemiologic and in vitro studies do not prove a cause-and-effect relationship between infection and preterm birth. However, the preponderance of evidence indicates that treatment of asymptomatic bacteriuria and symptomatic lower genital tract infections such as bacterial vaginosis (BV), trichomoniasis, gonorrhea, and chlamydia will lower the risk of preterm delivery. Based on current evidence, pregnant women who note an abnormal vaginal discharge should be tested for BV, trichomonas, gonorrhea, and chlamydia. Those who test positive should be treated appropriately. A 3- to 7-day course of antibiotic treatment for asymptomatic bacteriuria during pregnancy is clinically indicated to reduce the risk of pyelonephritis and preterm delivery. Routine screening for chlamydia and gonorrhea should be performed for women at high risk of acquiring sexually transmitted diseases. The practice of routine screening for BV in asymptomatic women who are at low risk for preterm delivery cannot be supported based on evidence from the literature. Routine screening for asymptomatic bacteriuria during pregnancy is cost-effective, particularly in high-prevalence populations. The results of antibiotic trials for the treatment of preterm labor have been inconsistent. In the absence of reasonable evidence that antimicrobial therapy leads to significant prolongation of pregnancy in the setting of preterm labor

  8. Policy and Purpose: The Economy of Deterrence

    Science.gov (United States)

    2009-01-01

    Schwartz.indd 11 2/2/09 2:29:38 PM Policy and Purpose The Economy of Deterrence Norton A. Schwartz, General, USAF Timothy R. Kirk, Lieutenant...00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE Policy and Purpose. The Economy of Deterrence 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...article concludes with an assessment of the economy of deterrence policy within the theory framework as we examine the implications for US Air

  9. 29 CFR 4000.26 - What if I use a commercial delivery service?

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false What if I use a commercial delivery service? 4000.26... § 4000.26 What if I use a commercial delivery service? (a) In general. Your filing or issuance date is the date you deposit your submission or issuance with the commercial delivery service if you meet...

  10. 48 CFR 29.401-1 - Indefinite-delivery contracts for leased equipment.

    Science.gov (United States)

    2010-10-01

    ... or places of delivery are not known at the time of contracting. ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Indefinite-delivery... ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES Contract Clauses 29.401-1 Indefinite-delivery...

  11. Assessment of cutaneous drug delivery using microdialysis

    DEFF Research Database (Denmark)

    Kreilgaard, Mads

    2002-01-01

    During the last decade microdialysis has been successfully applied to assess cutaneous drug delivery of numerous substances, indicating the large potential for bioequivalence/bioavailability evaluation of topical formulations. The technique has been shown to be minimally invasive and supply...... pharmacokinetic information directly in the target organ for cutaneous drug delivery with high temporal resolution without further intervention with the tissue after implantation. However, there are a few challenges that need to be addressed before microdialysis can be regarded as a generally applicable routine...... technique for cutaneous drug delivery assessments. Firstly, the technique is currently not suitable for sampling of highly lipophilic compounds and, secondly, more studies are desirable for elucidation of the variables associated with the technique to increase reproducibility. The present literature...

  12. Light activated liposomes: Functionality and prospects in ocular drug delivery.

    Science.gov (United States)

    Lajunen, Tatu; Nurmi, Riikka; Kontturi, Leena; Viitala, Lauri; Yliperttula, Marjo; Murtomäki, Lasse; Urtti, Arto

    2016-12-28

    Ocular drug delivery, especially to the retina and choroid, is a major challenge in drug development. Liposome technology may be useful in ophthalmology in enabling new routes of delivery, prolongation of drug action and intracellular drug delivery, but drug release from the liposomes should be controlled. For that purpose, light activation may be an approach to release drug at specified time and site in the eye. Technical advances have been made in the field of light activated drug release, particularly indocyanine green loaded liposomes are a promising approach with safe materials and effective light triggered release of small and large molecules. This review discusses the liposomal drug delivery with light activated systems in the context of ophthalmic drug delivery challenges.

  13. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Møller Larsen, Marcus; Bharati, Pratyush M.

    2015-01-01

    Global delivery models (GDMs) are transforming the global IT and business process outsourcing industry. GDMs are a new form of client-specific investment promoting service integration with clients by combining client proximity with time-zone spread for 24/7 service operations. We investigate...... antecedents and contingencies of setting up GDM structures. Based on comprehensive data we show that providers are likely to establish GDM location configurations when clients value access to globally distributed talent and speed of service delivery, in particular when services are highly commoditized...

  14. Polysaccharides for the Delivery of Antitumor Drugs

    Directory of Open Access Journals (Sweden)

    Bianca Posocco

    2015-05-01

    Full Text Available Among the several delivery materials available so far, polysaccharides represent very attractive molecules as they can undergo a wide range of chemical modifications, are biocompatible, biodegradable, and have low immunogenic properties. Thus, polysaccharides can contribute to significantly overcome the limitation in the use of many types of drugs, including anti-cancer drugs. The use of conventional anti-cancer drugs is hampered by their high toxicity, mostly depending on the indiscriminate targeting of both cancer and normal cells. Additionally, for nucleic acid based drugs (NABDs, an emerging class of drugs with potential anti-cancer value, the practical use is problematic. This mostly depends on their fast degradation in biological fluids and the difficulties to cross cell membranes. Thus, for both classes of drugs, the development of optimal delivery materials is crucial. Here we discuss the possibility of using different kinds of polysaccharides, such as chitosan, hyaluronic acid, dextran, and pullulan, as smart drug delivery materials. We first describe the main features of polysaccharides, then a general overview about the aspects ruling drug release mechanisms and the pharmacokinetic are reported. Finally, notable examples of polysaccharide-based delivery of conventional anti-cancer drugs and NABDs are reported. Whereas additional research is required, the promising results obtained so far, fully justify further efforts, both in terms of economic support and investigations in the field of polysaccharides as drug delivery materials.

  15. Pharmacosomes: A Potential Vesicular Drug Delivery System

    Directory of Open Access Journals (Sweden)

    D. Nagasamy Venkatesh

    2014-04-01

    Full Text Available Lipid based drug delivery systems have been examined in various studies and exhibited their potential in controlled and targeted drug delivery. Pharmacosomes, a novel vesicular drug delivery system, offering a unique advantage over liposomes and niosomes, and serve as potential alternative to these conventional vesicles. They constitute an amphiphilic phospholipid complex with drug bearing an active hydrogen atom covalently that bind to phospholipids. They provide an efficient delivery of drug required at the site of action, which ultimately reduces the drug toxicity with reduced adverse effects and also reduces the cost of therapy by imparting better biopharmaceutical properties to the drug, resulting in increases bioavailability, especially in case of poorly soluble drugs. As the system is formed by binding the drug (pharmakon to carrier (soma, they are termed as pharmacosomes. Depending upon the chemical structure of the drug lipid complex they may exist as ultrafine vesicular, micellar and hexagonal aggregate. Drug having active hydrogen group such as carboxyl, hydroxyl group can be esterified to lipids, resulting in amphiphilic compound. Pharmacosomes are widely used as carriers for various non-steroidal anti-inflammatory drugs, proteins, cardiovascular and antineoplastic drugs. The release of drug from pharmacosomes is generally governed by the process of enzymatic reaction and acid hydrolysis. Here, in the present review paper we have discussed the potential of pharmacosomes as a controlled and targeted drug delivery system and highlighted the method of preparation and characterization.

  16. Delivery of confidential care to adolescent males.

    Science.gov (United States)

    Rubin, Susan E; McKee, M Diane; Campos, Giselle; O'Sullivan, Lucia F

    2010-01-01

    Primary care providers' (PCPs') provision of time alone with an adolescent without the parents present (henceforth referred to as "confidential care") has a significant impact on adolescents' disclosure of risk behavior. To inform the development of interventions to improve PCPs' delivery of confidential care, we obtained the perspectives of adolescent males and their mothers about the health care concerns of adolescent males and the provision of confidential care. This focus-group study (5 groups: 2 with adolescent males and 2 with mothers) used standard qualitative methods for analysis. We recruited mother/son dyads who had been seen at urban primary care practices. Adolescents' health concerns focused on pregnancy and sexually transmitted infections; mothers took a broader view. Many adolescents felt that PCPs often delivered safe sex counseling in a superficial, impersonal manner that did not add much value to what they already knew, and that their PCP's principal role was limited to performing sexually transmitted infection testing. Though adolescents cited a number of advantages of confidential care and disclosure, they expressed some general mistrust in PCPs and concerns about limits of confidentiality. Rapport and relationship building with their PCP are key elements to adolescents' comfort and increased disclosure. Overall, mothers viewed confidential care positively, especially in the context of continuity of care, but many felt excluded. To increase adolescents' perception of the relevance of primary care and to foster disclosure during health encounters, our participants described the critical nature of a strong doctor-patient relationship and positive physician demeanor and personalized messages, especially in the context of a continuity relationship. Regular, routine inclusion of confidential care time starting early in adolescence, as well as discussion of the purpose and limitations of confidentiality with parents and adolescents, could lead to

  17. TRANSDERMAL DRUG DELIVERY SYSTEM: REVIEW

    Directory of Open Access Journals (Sweden)

    Virendra Yadav

    2012-01-01

    Full Text Available Transdermal drug delivery system (TDDS are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. It works very simply in which drug is applied inside the patch and it is worn on skin for long period of time. By this constant concentration of drug remain in blood for long time. Polymer matrix, drug, permeation enhancers are the main components of TDDS; polymers includes Zein, Shellac (as a natural to synthetic ones (Polybutadiene, Polysiloxane, Polyvinyl chloride, Polyvinyl alcohol etc.. TDDS are of many types varying from single layer drug in adhesive to multi layer drug in adhesive and others are reservoir and the matrix systems. The market value of TDDS products are increasing with rapid rate, more than 35 products have now been approved for sale in US, and approximately 16 active ingredients are approved globally for use as a TDDS. Transdermal drug delivery is a recent technology which promises a great future it has a potential to limit the use of needles for administering wide variety of drugs but cost factor is a important thing to consider since developing nations like INDIA have second highest population, but due to higher cost TDDS are the hidden part of therapy used in general population.

  18. Ethical issues in cesarean delivery.

    Science.gov (United States)

    Chervenak, Frank A; McCullough, Laurence B

    2017-08-01

    Cesarean delivery is the most common and important surgical intervention in obstetric practice. Ethics provides essential guidance to obstetricians for offering, recommending, recommending against, and performing cesarean delivery. This chapter provides an ethical framework based on the professional responsibility model of obstetric ethics. This framework is then used to address two especially ethically challenging clinical topics in cesarean delivery: patient-choice cesarean delivery and trial of labor after cesarean delivery. This chapter emphasizes a preventive ethics approach, designed to prevent ethical conflict in clinical practice. To achieve this goal, a preventive ethics approach uses the informed consent process to offer cesarean delivery as a medically reasonable alternative to vaginal delivery, to recommend cesarean delivery, and to recommend against cesarean delivery. The limited role of shared decision making is also described. The professional responsibility model of obstetric ethics guides this multi-faceted preventive ethics approach. Copyright © 2017. Published by Elsevier Ltd.

  19. Cyclodextrin nanoassemblies: a promising tool for drug delivery.

    Science.gov (United States)

    Bonnet, Véronique; Gervaise, Cédric; Djedaïni-Pilard, Florence; Furlan, Aurélien; Sarazin, Catherine

    2015-09-01

    Among the biodegradable and nontoxic compounds that can form nanoparticles for drug delivery, amphiphilic cyclodextrins are very promising. Apart from ionic cyclodextrins, which have been extensively studied and reviewed because of their application in gene delivery, our purpose is to provide a clear description of the supramolecular assemblies of nonionic amphiphilic cyclodextrins, which can form nanoassemblies for controlled drug release. Moreover, we focus on the relationship between their structure and physicochemical characteristics, which is crucial for self assembly and drug delivery. We also highlight the importance of the nanoparticle technology preparation for the stability and application of this nanodevice.

  20. PDMAEMA based gene delivery materials

    Directory of Open Access Journals (Sweden)

    Seema Agarwal

    2012-09-01

    Full Text Available Gene transfection is the transfer of genetic material like DNA into cells. Cationic polymers which form nanocomplexes with DNA, so-called non-viral gene vectors, are a highly promising platform for efficient gene transfection. Despite intensive research efforts and some of the on-going clinical trials on gene transfection, none of the existing cationic polymer systems are generally acceptable for human gene therapy. Since the process of gene transfection is complex and puts different challenges and demands on the delivery system, there is a strong requirement for the design and development of a multifunctional system in a simple way. This review will discuss recent efforts in design, synthesis, and performance of poly(2-dimethylaminoethyl methacrylate (PDMAEMA nanocomplexes with DNA.

  1. Digital dental photography. Part 2: Purposes and uses.

    Science.gov (United States)

    Ahmad, I

    2009-05-09

    Although the primary purpose of using digital photography in dentistry is for recording various aspects of clinical information in the oral cavity, other benefits also accrue. Detailed here are the uses of digital images for dento-legal documentation, education, communication with patients, dental team members and colleagues and for portfolios, and marketing. These uses enhance the status of a dental practice and improve delivery of care to patients.

  2. [Complications of cesarean deliveries].

    Science.gov (United States)

    Valgeirsdottir, Heiddis; Hardardottir, Hildur; Bjarnadottir, Ragnheidur I

    2010-01-01

    The objective of the study was to determine the rate of complications which accompany cesarean sections at Landspitali University Hospital (LSH). All deliveries by cesarean section from July 1st 2001 to December 31st 2002 were examined in a retrospective manner. Information was collected from maternity records regarding the operation and its complications if they occurred, during or following the operation. During this period 761 women delivered by cesarean section at LSH. The overall complication rate was 35,5%. The most common complications were; blood loss > or =1000 ml (16.5%), post operative fever (12.2%), extension from the uterine incision (7.2%) and need for blood transfusion (4.3%). Blood transfusion was most common in women undergoing cesarean section after attempted instrumental vaginal delivery (20%). Fever and extension from the uterine incision were most common in women undergoing cesarean section after full cervical dilation without attempt of instrumental delivery (19,4%). These complications were least likely to occur if the patient underwent an elective cesarean section. Complications following cesarean section are common, especially if labor is advanced. Each indication for an operative delivery should be carefully weighed and the patient informed accordingly.

  3. A Medical Delivery Device

    DEFF Research Database (Denmark)

    2010-01-01

    The present invention relates to a medical delivery device comprising at least two membrane electrode assembly units each of which comprises three layers: an upper and a lower electrode and a selective ionic conductive membrane provided there-between. At least one of the three layers are shared...

  4. Recovering from Delivery

    Science.gov (United States)

    ... suicidal thoughts, or any thoughts of harming your baby While recovering from delivery can be a lot to handle, things will get easier. Before you know it, you will be able to fully focus on enjoying your new baby. Reviewed by: Larissa Hirsch, MD Date reviewed: June ...

  5. A Medical Delivery Device

    DEFF Research Database (Denmark)

    2010-01-01

    The present invention relates to a medical delivery device comprising at least two membrane electrode assembly units each of which comprises three layers: an upper and a lower electrode and a selective ionic conductive membrane provided there-between. At least one of the three layers are shared...

  6. Self-nanoemulsifying drug delivery systems for oral insulin delivery

    DEFF Research Database (Denmark)

    Li, Ping; Tan, Angel; Prestidge, Clive A

    2014-01-01

    This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10% w...

  7. Is non-directive counseling for patient choice cesarean delivery ethically justified?

    Science.gov (United States)

    Kalish, Robin B; McCullough, Laurence B; Chervenak, Frank A

    2007-01-01

    The current controversy concerning patient choice cesarean delivery potentially affects all women of child-bearing age and the physicians who care for them. The purpose of this paper is to address three salient issues within the patient choice cesarean delivery controversy. First, is performing patient choice cesarean delivery consistent with good professional medical practice? Second, how should physicians respond to or counsel patients who request patient choice cesarean delivery? And, third, should patient choice cesarean delivery be routinely offered to all pregnant women?

  8. Attempted operative vaginal delivery vs repeat cesarean in the second stage among women undergoing a trial of labor after cesarean delivery.

    Science.gov (United States)

    Son, Moeun; Roy, Archana; Grobman, William A

    2017-04-01

    It is not well-characterized whether attempting operative vaginal delivery is a safe and effective alternative among women who undergo a trial of labor after cesarean delivery who are unable to complete second-stage labor with a spontaneous vaginal delivery. The purpose of this study was to compare maternal and neonatal outcomes that are associated with attempted operative vaginal delivery with those that are associated with second-stage repeat cesarean delivery without an operative vaginal delivery attempt among women who undergo a trial of labor after cesarean delivery. This is a retrospective secondary analysis of data from Cesarean Registry of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Women who underwent a trial of labor after cesarean delivery who were at least 36 weeks gestation were eligible for analysis if they had a live, singleton, nonanomalous gestation in cephalic presentation and reached second-stage labor (defined as complete cervical dilation) with a fetal station of at least +2. The data for women who had an attempted operative vaginal delivery with either forceps or vacuum were compared with those of women who underwent second stage repeat cesarean delivery without operative vaginal delivery attempt. Outcomes of maternal and neonatal complications were compared between groups with bivariable and multivariable analyses. Of 1230 women whose cases were eligible for analysis, 945 women (76.8%) had an attempted operative vaginal delivery. Of those who underwent attempted operative vaginal delivery, 914 women (96.7%) achieved a vaginal delivery. Women who attempted operative vaginal delivery had a lower mean body mass index (30.4±6.0 vs 31.8±5.9 kg/m(2); P=.001) and gestational age (39.5±1.3 vs 39.8±1.2 weeks; P=.012) at delivery and were more likely to be of non-Hispanic black race (30.0% vs 22.1%; P=.002), to have had a previous vaginal delivery (34.9% vs 20

  9. [Preterm delivery: detection of risks and preventive treatment].

    Science.gov (United States)

    Althabe, F; Carroli, G; Lede, R; Belizán, J M; Althabe, O H

    1999-06-01

    Every year around the world some 13 million premature children are born. Most of these children are born in developing countries, and they account for the largest share of perinatal morbidity and mortality. This review study analyzed scientifically validated data on interventions to prevent at least some portion of these preterm deliveries and to lessen their impact on neonatal health. The Cochrane and MEDLINE bibliographic databases were consulted. Fifty review pieces and research articles were studied, relating to the following aspects of preterm delivery: risk factors and early detection of the risk of preterm delivery; preventing the risk of preterm delivery; treating preterm delivery once it has begun; and preventing neonatal respiratory distress syndrome. There were few successful approaches to the prediction, prevention, or early detection of the threat of preterm delivery. The only measures that can be recommended for all pregnant women are screening for and treating asymptomatic bacteriuria as a part of prenatal check-ups. Screening for bacterial vaginosis and treating it reduce the incidence of preterm births in pregnant women with a history of premature delivery. In addition, prophylactic cerclage decreases the incidence of premature births in pregnant women who have had more than three preterm births. To treat a delivery that starts early, with or without premature membrane rupture, the interventions that have proved to be effective are administering betamimetics to the parturient woman in order to delay delivery for 48 hours, and using indomethacin for the same purpose, as the second-choice drug. The prenatal administration of corticosteroids to the pregnant woman can induce lung maturation in the fetus and reduce respiratory distress syndrome and ventricular hemorrhage, thus decreasing neonatal mortality. There is a need to continue and support basic and epidemiological research in order to develop new knowledge on the causes and mechanisms of preterm

  10. 46 CFR Section 1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Purpose. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION B-CONTROL AND UTILIZATION OF PORTS FEDERAL PORT CONTROLLERS Section 1 Purpose. This part prescribes the standard form of the service agreement to be entered into by the...

  11. CURRENT TRENDS IN PULSATILE DRUG DELIVERY SYSTEMS

    Directory of Open Access Journals (Sweden)

    S. R. Tajane et al.

    2012-01-01

    Full Text Available The purpose for this review on pulsatile drug delivery systems (PDDS is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation. Pulsatile drug delivery system is the most interesting time and site-specific system. This system is designed for chronopharmacotherapy. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, pulsatile delivery, which is meant to release a drug following programmed lag phase, has increasing interest in the recent years. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, and attention deficit syndrome in children, cancer, diabetes, and hypercholesterolemia. Pulsatile drug delivery system divided into 2 types’ preplanned systems and stimulus induced system, preplanned systems based on osmosis, rupturable layers, and erodible barrier coatings. Stimuli induced system based on electrical, temperature and chemically induced systems. This review also summarizes some current PDDS already available in the market. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

  12. Nanotopography applications in drug delivery

    Science.gov (United States)

    Walsh, Laura A; Allen, Jessica L; Desai, Tejal A

    2016-01-01

    Refinement of micro- and nanofabrication in the semiconductor field has led to innovations in biomedical technologies. Nanotopography, in particular, shows great potential in facilitating drug delivery. The flexibility of fabrication techniques has created a diverse array of topographies that have been developed for drug delivery applications. Nanowires and nanostraws deliver drug cytosolically for in vitro and ex vivo applications. In vivo drug delivery is limited by the barrier function of the epithelium. Nanowires on microspheres increase adhesion and residence time for oral drug delivery, while also increasing permeability of the epithelium. Low aspect ratio nanocolumns increase paracellular permeability, and in conjunction with microneedles increase transdermal drug delivery of biologics in vivo. In summary, nanotopography is a versatile tool for drug delivery. It can deliver directly to cells or be used for in vivo delivery across epithelial barriers. This editorial highlights the application of nanotopography in the field of drug delivery. PMID:26512871

  13. General Dentist

    Science.gov (United States)

    ... Some general dentists work in government health services, research programs, higher education, corporations and even the military. ?xml:namespace> What kind of procedures do general dentists provide? ?xml:namespace> Many general dentists are ...

  14. Optimizing drugs for local delivery.

    Science.gov (United States)

    Collingwood, S; Lock, R; Searcey, M

    2009-12-01

    An international panel of speakers together with approximately 70 delegates were brought together by The Society for Medicines Research's symposium on Optimising Drugs for Local Delivery, held on June 11, 2009 at the Novartis Institutes for Biomedical Research, Horsham, UK. The focus of the conference was on the delivery of drugs direct to the site of action and the consequences of this delivery route on delivery technologies, formulation science and molecular design.

  15. Microprocessor controlled transdermal drug delivery.

    Science.gov (United States)

    Subramony, J Anand; Sharma, Ashutosh; Phipps, J B

    2006-07-06

    Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, pre-programmed, and sensor-based delivery is highlighted. Unique features such as the use of tactile signaling, telemetry control, and pulsatile waveforms in iontophoretic drug delivery are described briefly.

  16. MEMS: Enabled Drug Delivery Systems.

    Science.gov (United States)

    Cobo, Angelica; Sheybani, Roya; Meng, Ellis

    2015-05-01

    Drug delivery systems play a crucial role in the treatment and management of medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. This Review presents the use of MEMS technologies to produce drug delivery devices detailing the delivery mechanisms, device formats employed, and various biomedical applications. The integration of dosing control systems, examples of commercially available microtechnology-enabled drug delivery devices, remaining challenges, and future outlook are also discussed.

  17. Relational Analysis for Delivery of Services

    DEFF Research Database (Denmark)

    Nielson, Flemming; Nielson, Hanne Riis; Bauer, Jörg

    2008-01-01

    substantially improves the precision of the results obtained while being able to deal with the full generality of the syntax of processes. The analysis reveals a feasible complexity for practical examples and gives rise to a fast prototype. We use this prototype to automatically prove the correct delivery...... of messages for the implementation of an accident service, which is based on multiplexed communication, a crucial feature of global computing applications....

  18. What Is a Cesarean Delivery?

    Science.gov (United States)

    ... are common complications? What is a high-risk pregnancy? What is labor? What is a cesarean delivery? Other FAQs NICHD Research Information Clinical Trials Resources and Publications What is a cesarean delivery? Skip sharing on social media links Share this: Page Content A cesarean delivery ...

  19. Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System

    Science.gov (United States)

    Zhou, Huafeng; Yue, Yang; Liu, Guanlan; Li, Yan; Zhang, Jing; Gong, Qiu; Yan, Zemin; Duan, Mingxing

    2010-01-01

    Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimental results demonstrated that an increasing concentration of soybean lecithin and glycerol resulted in a smaller size LNE droplet and increasing viscosity, respectively. The droplet size of optimized LNE, with the glycerol concentration above 75% (w/w), changed from 92 (F10) to 58 nm (F14). Additionally, LNE, incorporated into o/w cream, improved the skin hydration capacity of the cream significantly with about 2.5-fold increase when the concentration of LNE reached 10%. LNE was also demonstrated to improve the penetrability of Nile red (NR) dye into the dermis layer, when an o/w cream, incorporated with NR-loaded LNE, applied on the abdominal skin of rat in vivo. Specifically, the arbitrary unit (ABU) of fluorescence in the dermis layer that had received the cream with a NR-loaded LNE was about 9.9-fold higher than the cream with a NR-loaded general emulsion (GE). These observations suggest that LNE could be used as a promising topical delivery vehicle for lipophilic compounds.

  20. Treatment history and outcome of 24 deliveries worldwide after autotransplantation of cryopreserved ovarian tissue, including two new Danish deliveries years after autotransplantation

    DEFF Research Database (Denmark)

    Macklon, Kirsten T; Jensen, Annette Klüver; Loft, Anne

    2014-01-01

    PURPOSE: To report another two successful pregnancies and deliveries resulting from autotransplanted cryopreserved ovarian tissue several years after the autotransplantation procedure took place. Further, to review the literature on the treatment history, number of live births and their outcome so...

  1. Mucoadhesive drug delivery systems

    Directory of Open Access Journals (Sweden)

    Rahamatullah Shaikh

    2011-01-01

    Full Text Available Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal.

  2. Social video content delivery

    CERN Document Server

    Wang, Zhi; Zhu, Wenwu

    2016-01-01

    This brief presents new architecture and strategies for distribution of social video content. A primary framework for socially-aware video delivery and a thorough overview of the possible approaches is provided. The book identifies the unique characteristics of socially-aware video access and social content propagation, revealing the design and integration of individual modules that are aimed at enhancing user experience in the social network context. The change in video content generation, propagation, and consumption for online social networks, has significantly challenged the traditional video delivery paradigm. Given the massive amount of user-generated content shared in online social networks, users are now engaged as active participants in the social ecosystem rather than as passive receivers of media content. This revolution is being driven further by the deep penetration of 3G/4G wireless networks and smart mobile devices that are seamlessly integrated with online social networking and media-sharing s...

  3. Pyomyositis after vaginal delivery.

    LENUS (Irish Health Repository)

    Gaughan, Eve

    2011-01-01

    Pyomyositis is a purulent infection of skeletal muscle that arises from haematogenous spread, usually with abscess formation. It can develop after a transient bacteraemia of any cause. This type of infection has never been reported before in the literature after vaginal delivery. A 34-year-old woman had progressive severe pain in the left buttock and thigh and weakness in the left lower limb day 1 post spontaneous vaginal delivery. MRI showed severe oedema of the left gluteus, iliacus, piriformis and adductor muscles of the left thigh and a small fluid collection at the left hip joint. She was diagnosed with pyomyositis. She had fever of 37.9°C immediately postpartum and her risk factors for bacteraemia were a mild IV cannula-associated cellulitis and labour itself. She required prolonged treatment with antibiotics before significant clinical improvement was noted.

  4. Delivery strategies for antiparasitics.

    Science.gov (United States)

    Kayser, Oliver; Kiderlen, Albrecht F

    2003-02-01

    Optimisation of drug carrier systems and drug delivery strategies that take into account the peculiarities of individual infectious agents and diseases are key elements of modern drug development. In the following, different aspects of a rational design for antiparasitic drug formulation will be reviewed, covering delivery systems such as nano- and microparticles, liposomes, emulsions and microemulsions, cochleates and bioadhesive macromolecules. Functional properties for each carrier system will be discussed as well as their therapeutic efficacy for parasitic diseases, including leishmaniasis, human African trypanosomiasis, human cryptosporidiosis, malaria and schistosomiasis. Critical issues for the application of drug carrier systems will be discussed, focusing on biopharmaceutical and pathophysiological parameters such as routes of application, improvement of body distribution and targeting intracellularly persisting pathogens.

  5. Transcutaneous antigen delivery system

    Directory of Open Access Journals (Sweden)

    Mi-Young Lee

    2013-01-01

    Full Text Available Transcutaneous immunization refers to the topical applicationof antigens onto the epidermis. Transcutaneous immunizationtargeting the Langerhans cells of the skin has received muchattention due to its safe, needle-free, and noninvasive antigendelivery. The skin has important immunological functions withunique roles for antigen-presenting cells such as epidermalLangerhans cells and dermal dendritic cells. In recent years,novel vaccine delivery strategies have continually beendeveloped; however, transcutaneous immunization has not yetbeen fully exploited due to the penetration barrier representedby the stratum corneum, which inhibits the transport ofantigens and adjuvants. Herein we review recent achievementsin transcutaneous immunization, focusing on the variousstrategies for the enhancement of antigen delivery andvaccination efficacy. [BMB Reports 2013; 46(1: 17-24

  6. Transdermal Delivery of Proteins

    OpenAIRE

    Kalluri, Haripriya; Banga, Ajay K.

    2011-01-01

    Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows the transport of only small lipophilic drug molecules. Enhancement techniques such as chemical enhancers, iontophoresis, microneedles, electro...

  7. Auditing Information System : Delivery Product Service

    Directory of Open Access Journals (Sweden)

    Purwoko Purwoko

    2011-05-01

    Full Text Available Purpose of the research is to ensure the securities of information system asset and to ensure if informa-tion system support the operational and data collected was valid. Research method that used in this research were library studies and field studies. Field studies such an observation, questioner, and inter-view. the expected result are founding the weakness of security management control, operational man-agement control, input control, and output control of risk happened in the company. Conclusion of this research are the system on the company work good and there’s no potential risk happened and make an impact to the delivery process of information system.Index Terms - Auditing Information system, Delivery product process.

  8. Magnetic targeting strategies in gene delivery.

    Science.gov (United States)

    Delyagina, Evgenya; Li, Wenzhong; Ma, Nan; Steinhoff, Gustav

    2011-11-01

    Gene delivery is a process of the insertion of transgenes into cells with the purpose to obtain the expression of encoded protein. The therapeutic application of this process is termed gene therapy, which is becoming a promising instrument to treat genetic and acquired diseases. Although numerous methods of gene transfer have already been developed, including biological, physical and chemical approaches, the optimal strategy has to be discovered. Importantly, it should be effective, selective and safe to be translated to the clinic. Magnetic targeting has been demonstrated as an effective strategy to decrease side effects of gene transfer, while increasing the selectivity and efficiency of the applied vector. This article will focus on the latest progress in the development of different magnetic vectors, based on both viral and nonviral gene delivery agents. It will also include a description of magnetic targeting applications in stem cells and in vivo, which has gained interest in recent years due to the rapid development of technology.

  9. Multi-Purpose Test Stand

    Data.gov (United States)

    Federal Laboratory Consortium — The Multi-Purpose Test Stand is used for a wide variety of tests. The Stand is designed to be rotated through a range of fixed yaw positions to allow engines to be...

  10. Cafeteria/Multi-Purpose Spaces.

    Science.gov (United States)

    Larsen, Christopher W.

    2001-01-01

    Highlights school cafeteria design criteria that creates dining facilities that are both social areas as well as eating spaces. Also examined are key design considerations for multi-purpose areas. (GR)

  11. Multi-Purpose Test Stand

    Data.gov (United States)

    Federal Laboratory Consortium — The Multi-Purpose Test Stand is used for a wide variety of tests. The Stand is designed to be rotated through a range of fixed yaw positions to allow engines to be...

  12. 49 CFR 1180.0 - Scope and purpose.

    Science.gov (United States)

    2010-10-01

    ... OF TRANSPORTATION RULES OF PRACTICE RAILROAD ACQUISITION, CONTROL, MERGER, CONSOLIDATION PROJECT, TRACKAGE RIGHTS, AND LEASE PROCEDURES General Acquisition Procedures § 1180.0 Scope and purpose. (a... followed in control, merger, acquisition, lease, trackage rights, and any other consolidation...

  13. 16 CFR 1.91 - Authority and purpose.

    Science.gov (United States)

    2010-01-01

    ... PROCEDURES Economic Surveys, Investigations and Reports § 1.91 Authority and purpose. General and special economic surveys, investigations, and reports are made by the Bureau of Economics under the authority...

  14. 16 CFR 1031.16 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION PARTICIPATION AND COMMISSION EMPLOYEE INVOLVEMENT IN VOLUNTARY STANDARDS ACTIVITIES Public Participation and Comment § 1031.16 Purpose and scope. (a) This subpart sets forth the Consumer Product Safety Commission's criteria...

  15. 16 CFR 1031.9 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION PARTICIPATION AND COMMISSION EMPLOYEE INVOLVEMENT IN VOLUNTARY STANDARDS ACTIVITIES Employee Involvement § 1031.9 Purpose and scope. (a) This subpart sets forth the Consumer Product Safety Commission's criteria and requirements...

  16. 50 CFR 654.1 - Purpose and scope.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF COMMERCE STONE CRAB FISHERY OF THE GULF OF MEXICO General Measures § 654.1 Purpose and scope... of the Gulf of Mexico, prepared by the Gulf of Mexico Fishery Management Council under the...

  17. Electroresponsive nanoparticles for drug delivery on demand

    Science.gov (United States)

    Samanta, Devleena; Hosseini-Nassab, Niloufar; Zare, Richard N.

    2016-04-01

    The potential of electroresponsive conducting polymer nanoparticles to be used as general drug delivery systems that allow electrically pulsed, linearly scalable, and on demand release of incorporated drugs is demonstrated. As examples, facile release from polypyrrole nanoparticles is shown for fluorescein, a highly water-soluble model compound, piroxicam, a lipophilic small molecule drug, and insulin, a large hydrophilic peptide hormone. The drug loading is about 13 wt% and release is accomplished in a few seconds by applying a weak constant current or voltage. To identify the parameters that should be finely tuned to tailor the carrier system for the release of the therapeutic molecule of interest, a systematic study of the factors that affect drug delivery is performed, using fluorescein as a model compound. The parameters studied include current, time, voltage, pH, temperature, particle concentration, and ionic strength. Results indicate that there are several degrees of freedom that can be optimized for efficient drug delivery. The ability to modulate linearly drug release from conducting polymers with the applied stimulus can be utilized to design programmable and minimally invasive drug delivery devices.

  18. 29 CFR 552.2 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... FAIR LABOR STANDARDS ACT TO DOMESTIC SERVICE General Regulations § 552.2 Purpose and scope. (a) This... accordance with the following amendments made by the Fair Labor Standards Amendments of 1974, 88 Stat. 55, et... 29 Labor 3 2010-07-01 2010-07-01 false Purpose and scope. 552.2 Section 552.2 Labor Regulations...

  19. 7 CFR 550.51 - Purpose of reports and records.

    Science.gov (United States)

    2010-01-01

    ... OF AGRICULTURE GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS Management of Agreements Reports and Records § 550.51 Purpose of reports and records. Sections 550.52 through 550.55 set... 7 Agriculture 6 2010-01-01 2010-01-01 false Purpose of reports and records. 550.51 Section...

  20. 42 CFR 403.700 - Basis and purpose.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and purpose. 403.700 Section 403.700 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... of Participation, and Payment § 403.700 Basis and purpose. This subpart implements sections...

  1. 33 CFR 385.1 - Purpose of the programmatic regulations.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Purpose of the programmatic..., DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS FOR THE COMPREHENSIVE EVERGLADES RESTORATION PLAN General Provisions § 385.1 Purpose of the programmatic regulations. (a) The programmatic regulations of this...

  2. 29 CFR 2.10 - Scope and purpose.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Scope and purpose. 2.10 Section 2.10 Labor Office of the Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.10 Scope and purpose. This subpart defines the scope of audiovisual coverage of departmental administrative...

  3. Developing a Commercial Air Ultrasonic Ceramic Transducer to Transdermal Insulin Delivery

    OpenAIRE

    Jabbari, Nasrollah; Asghari, Mohammad Hossein; Ahmadian, Hassan; Mikaili, Peyman

    2015-01-01

    The application of low-frequency ultrasound for transdermal delivery of insulin is of particular public interest due to the increasing problem of diabetes. The purpose of this research was to develop an air ultrasonic ceramic transducer for transdermal insulin delivery and evaluate the possibility of applying a new portable and low-cost device for transdermal insulin delivery. Twenty-four rats were divided into four groups with six rats in each group: one control group and three experimental ...

  4. Routes of administration of cannabis used for nonmedical purposes and associations with patterns of drug use.

    OpenAIRE

    Baggio, S.; Deline, S.; Studer, J.; Mohler-Kuo, M.; Daeppen, J.B.; Gmel, G.

    2014-01-01

    PURPOSE: Little is known regarding cannabis administration routes for nonmedical use-that is, its delivery methods (e.g., joints, water pipe, food). Therefore, we examined the prevalence rates of different cannabis delivery methods and assessed the relationship of the distinct administration routes with problematic drug use. Subgroups of cannabis users were also investigated (i.e., "pure" cannabis users, previously described as employing a harmless route of administration, and water pipe user...

  5. Bacteriophage Procurement for Therapeutic Purposes.

    Science.gov (United States)

    Weber-Dąbrowska, Beata; Jończyk-Matysiak, Ewa; Żaczek, Maciej; Łobocka, Małgorzata; Łusiak-Szelachowska, Marzanna; Górski, Andrzej

    2016-01-01

    Bacteriophages (phages), discovered 100 years ago, are able to infect and destroy only bacterial cells. In the current crisis of antibiotic efficacy, phage therapy is considered as a supplementary or even alternative therapeutic approach. Evolution of multidrug-resistant and pandrug-resistant bacterial strains poses a real threat, so it is extremely important to have the possibility to isolate new phages for therapeutic purposes. Our phage laboratory and therapy center has extensive experience with phage isolation, characterization, and therapeutic application. In this article we present current progress in bacteriophages isolation and use for therapeutic purposes, our experience in this field and its practical implications for phage therapy. We attempt to summarize the state of the art: properties of phages, the methods for their isolation, criteria of phage selection for therapeutic purposes and limitations of their use. Perspectives for the use of genetically engineered phages to specifically target bacterial virulence-associated genes are also briefly presented.

  6. Multifunctional Nanoparticles for Drug Delivery Applications Imaging, Targeting, and Delivery

    CERN Document Server

    Prud'homme, Robert

    2012-01-01

    This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. Unlike other books covering nanoparticles used in medical applications, Multifunctional Nanoparticles for Drug Delivery Applications presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

  7. Metrology for drug delivery.

    Science.gov (United States)

    Lucas, Peter; Klein, Stephan

    2015-08-01

    In various recently published studies, it is argued that there are underestimated risks with infusion technology, i.e., adverse incidents believed to be caused by inadequate administration of the drugs. This is particularly the case for applications involving very low-flow rates, i.e., metrological infrastructure for low-flow rates. Technical challenges such as these were the reason a European research project "Metrology for Drug Delivery" was started in 2011. In this special issue of Biomedical Engineering, the results of that project are discussed.

  8. Content Planning and Delivery in a Flipped Classroom: A Qualitative Examination

    Science.gov (United States)

    Oyola, Michelle

    2016-01-01

    The problem this qualitative case study addressed is the lack of a clear model for flipping all content planning and delivery in elementary classrooms. The purpose of this study was to create a model of how to flip all aspects of content planning and delivery in an elementary classroom. A total of 11 teachers were recruited to participate. All…

  9. Client satisfaction with service delivery of assistive technology for outdoor mobility

    NARCIS (Netherlands)

    Jedeloo, S; De Witte, LP; Linssen, BAJ; Schrijvers, AJP

    2002-01-01

    Purpose: In the decentralized Dutch service delivery system, client satisfaction levels for the provision of assistive technology (AT) for outdoor mobility for elderly and disabled persons was measured to investigate whether or not differences exist between local service delivery systems and if so,

  10. Client satisfaction with service delivery of assistive technology for outdoor mobility

    NARCIS (Netherlands)

    Jedeloo, S; De Witte, LP; Linssen, BAJ; Schrijvers, AJP

    Purpose: In the decentralized Dutch service delivery system, client satisfaction levels for the provision of assistive technology (AT) for outdoor mobility for elderly and disabled persons was measured to investigate whether or not differences exist between local service delivery systems and if so,

  11. Design Project on Controlled-Release Drug Delivery Devices: Implementation, Management, and Learning Experiences

    Science.gov (United States)

    Xu, Qingxing; Liang, Youyun; Tong, Yen Wah; Wang, Chi-Hwa

    2010-01-01

    A design project that focuses on the subject of controlled-release drug delivery devices is presented for use in an undergraduate course on mass transfer. The purpose of the project is to introduce students to the various technologies used in the fabrication of drug delivery systems and provide a practical design exercise for understanding the…

  12. Influences of Teacher Delivery, Student Engagement, and Observation Focus on Preservice Teachers' Perceptions of Teaching Effectiveness

    Science.gov (United States)

    Napoles, Jessica; MacLeod, Rebecca B.

    2016-01-01

    The purpose of this study was to examine how teacher delivery, student engagement, and observation focus influenced preservice teachers' ratings of teaching effectiveness. Participants (N = 84 preservice teachers) viewed short teaching excerpts of orchestral and choral rehearsals wherein the teacher displayed either high or low teacher delivery,…

  13. Modelling healthcare internal service supply chains for the analysis of medication delivery errors and amplification effects

    Directory of Open Access Journals (Sweden)

    Banafsheh Behzad

    2011-12-01

    Full Text Available Purpose: Healthcare is a universally used service that hugely affects economies and the quality of life. The research of service supply chains has found a significant role in the past decade. The main research goal of this paper is to model and simulate the internal service supply chains of a healthcare system to study the effects of different parameters on the outputs and capability measures of the processes. The specific objectives are to analyse medication delivery errors in a community hospital based on the results of the models and to explore the presence of bullwhip effect in the internal service supply chains of the hospital.Design/methodology/approach: System dynamics which is an approach for understanding the behaviour of complex systems, used as a methodology to model two internal service supply chains of the hospital with a sub-model created to simulate medication delivery errors in the hospital. The models are validated using the actual data of the hospital and the results are analyzed based on experimental design techniques.Findings: It is observed that the bullwhip effect may not occur in a hospital’s internal service supply chains. Furthermore the paper points out the conditions for reducing the medication delivery error in a hospital.Research limitations/implications: Because of the community hospital’s data availability the type of service supply chains modelled in this paper, are small service supply chains, representing only the tasks which are done inside the hospital. To better observe the bullwhip effect in healthcare service supply chains, the chains should be modelled more generally.Originality/value: The original system dynamics modelling of the internal service supply chains of a community hospital, with a sub-model simulating the medication delivery error.

  14. Delivery of a small for gestational age infant and greater maternal risk of ischemic heart disease.

    Directory of Open Access Journals (Sweden)

    Radek Bukowski

    Full Text Available BACKGROUND: Delivery of a small for gestational age (SGA infant has been associated with increased maternal risk of ischemic heart disease (IHD. It is uncertain whether giving birth to SGA infant is a specific determinant of later IHD, independent of other risk factors, or a marker of general poor health. The purpose of this study was to investigate the association between delivery of a SGA infant and maternal risk for IHD in relation to traditional IHD risk factors. METHODS AND FINDINGS: Risk of maternal IHD was evaluated in a population based cross-sectional study of 6,608 women with a prior live term birth who participated in the National Health and Nutrition Examination Survey (1999-2006, a probability sample of the U.S. population. Sequence of events was determined from age at last live birth and at diagnosis of IHD. Delivery of a SGA infant is strongly associated with greater maternal risk for IHD (age adjusted OR; 95% CI: 1.8; 1.2, 2.9; p = 0.012. The association was independent of the family history of IHD, stroke, hypertension and diabetes (family history-adjusted OR; 95% CI: 1.9; 1.2, 3.0; p = 0.011 as well as other risk factors for IHD (risk factor-adjusted OR; 95% CI: 1.7; 1.1, 2.7; p = 0.025. Delivery of a SGA infant was associated with earlier onset of IHD and preceded it by a median of 30 (interquartile range: 20, 36 years. CONCLUSIONS: Giving birth to a SGA infant is strongly and independently associated with IHD and a potential risk factor that precedes IHD by decades. A pregnancy that produces a SGA infant may induce long-term cardiovascular changes that increase risk for IHD.

  15. Delivery of a small for gestational age infant and greater maternal risk of ischemic heart disease.

    Science.gov (United States)

    Bukowski, Radek; Davis, Karen E; Wilson, Peter W F

    2012-01-01

    Delivery of a small for gestational age (SGA) infant has been associated with increased maternal risk of ischemic heart disease (IHD). It is uncertain whether giving birth to SGA infant is a specific determinant of later IHD, independent of other risk factors, or a marker of general poor health. The purpose of this study was to investigate the association between delivery of a SGA infant and maternal risk for IHD in relation to traditional IHD risk factors. Risk of maternal IHD was evaluated in a population based cross-sectional study of 6,608 women with a prior live term birth who participated in the National Health and Nutrition Examination Survey (1999-2006), a probability sample of the U.S. population. Sequence of events was determined from age at last live birth and at diagnosis of IHD. Delivery of a SGA infant is strongly associated with greater maternal risk for IHD (age adjusted OR; 95% CI: 1.8; 1.2, 2.9; p = 0.012). The association was independent of the family history of IHD, stroke, hypertension and diabetes (family history-adjusted OR; 95% CI: 1.9; 1.2, 3.0; p = 0.011) as well as other risk factors for IHD (risk factor-adjusted OR; 95% CI: 1.7; 1.1, 2.7; p = 0.025). Delivery of a SGA infant was associated with earlier onset of IHD and preceded it by a median of 30 (interquartile range: 20, 36) years. Giving birth to a SGA infant is strongly and independently associated with IHD and a potential risk factor that precedes IHD by decades. A pregnancy that produces a SGA infant may induce long-term cardiovascular changes that increase risk for IHD.

  16. Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system

    Energy Technology Data Exchange (ETDEWEB)

    Locatelli, Erica; Comes Franchini, Mauro, E-mail: mauro.comesfranchini@unibo.it [University of Bologna, Dipartimento di Chimica Industriale Toso Montanari (Italy)

    2012-12-15

    During the past decades many synthetic polymers have been studied for nanomedicine applications and in particular as drug delivery systems. For this purpose, polymers must be non-toxic, biodegradable, and biocompatible. Polylactic-co-glycolic acid (PLGA) is one of the most studied polymers due to its complete biodegradability and ability to self-assemble into nanometric micelles that are able to entrap small molecules like drugs and to release them into body in a time-dependent manner. Despite fine qualities, using PLGA polymeric nanoparticles for in vivo applications still remains an open challenge due to many factors such as poor stability in water, big diameter (150-200 nm), and the removal of these nanocarriers from the blood stream by the liver and spleen thus reducing the concentration of drugs drastically in tumor tissue. Polyethylene glycol (PEG) is the most used polymers for drug delivery applications and the first PEGylated product is already on the market for over 20 years. This is due to its stealth behavior that inhibits the fast recognition by the immune system (opsonization) and generally leads to a reduced blood clearance of nanocarriers increasing blood circulation time. Furthermore, PEG is hydrophilic and able to stabilize nanoparticles by steric and not ionic effects especially in water. PLGA-PEG block copolymer is an emergent system because it can be easily synthesized and it possesses all good qualities of PLGA and also PEG capability so in the last decade it arose as one of the most promising systems for nanoparticles formation, drug loading, and in vivo drug delivery applications. This review will discuss briefly on PLGA-b-PEG synthesis and physicochemical properties, together with its improved qualities with respect to the single PLGA and PEG polymers. Moreover, we will focus on but in particular will treat nanoparticles formation and uses as new drug delivery system for nanomedical applications.

  17. Current Practices in the Delivery of Undergraduate Exercise Physiology Content

    Science.gov (United States)

    Fisher, Michele M.

    2013-01-01

    The purpose of this study was to identify current practices for the delivery of exercise physiology content at the undergraduate level. An anonymous 22-item survey was sent to instructors of exercise physiology to collect information concerning the structure of course offerings and instructional practices. One hundred ten instructors responded to…

  18. The Effect of Leadership on Service Delivery in Universities

    Science.gov (United States)

    Zvavahera, Promise

    2013-01-01

    This study was aimed at assessing leadership effectiveness on service delivery at the University of Namibia and all its campuses throughout the country. The study was carried out during the month of February 2013. The methodology consisted of document analysis, interviews through face to face, video and tele-conferencing. Purposive sampling was…

  19. Viability, Advantages and Design Methodologies of M-Learning Delivery

    Science.gov (United States)

    Zabel, Todd W.

    2010-01-01

    The purpose of this study was to examine the viability and principle design methodologies of Mobile Learning models in developing regions. Demographic and market studies were utilized to determine the viability of M-Learning delivery as well as best uses for such technologies and methods given socioeconomic and political conditions within the…

  20. A Template for Analyzing Costs Associated with Educational Delivery Modes

    Science.gov (United States)

    Koenig, Robert J.

    2011-01-01

    The purpose of this research was to develop, test, and apply a framework for determining cost of alternative educational course delivery modes. This study reviews and analyzes the costs associated with traditional education and compares it to those costs associated with video conference and online distance education at a single institution. The…

  1. Formalizing and Enforcing Purpose Restrictions

    Science.gov (United States)

    2012-05-09

    1991. [JSNS09] Mohammad Jafari, Reihaneh Safavi-Naini, and Nicholas Paul Sheppard . Enforcing purpose of use via workflows. In WPES ’09: Proceedings of...American Medical Informatics Association, October 2011. [ZH01] Rong Zhou and Eric A. Hansen. An improved grid-based approximation algorithm for POMDPs

  2. Common Courses for Common Purposes:

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John

    2014-01-01

    (PME)? I suggest three alternative paths that increased cooperation in PME at the level of the command and staff course could take: a Nordic Defence College, standardized national command and staff courses, and a core curriculum of common courses for common purposes. I conclude with a discussion of how...

  3. Common Courses for Common Purposes:

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John

    2014-01-01

    (PME)? I suggest three alternative paths that increased cooperation in PME at the level of the command and staff course could take: a Nordic Defence College, standardized national command and staff courses, and a core curriculum of common courses for common purposes. I conclude with a discussion of how...

  4. CONTROLLED DRUG DELIVERY THROUGH MICROENCAPSULATION

    Directory of Open Access Journals (Sweden)

    NIKHIL K. SACHAN

    2006-01-01

    Full Text Available An appropriately designed controlled release drug delivery system can be a major advance towards solving problems concerning to the targeting of drug to a specific organ or tissue and controlling the rate of drug delivery to the target site. The development of oral controlled release systems has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of gastrointestinal tract. Microparticulate drug delivery systems are an interesting and promising option when developing an oral controlled release system. The objective of this paper is to take a closer look at microparticles as drug delivery devices for increasing efficiency of drug delivery, improving the release profile and drug targeting. In order to appreciate the application possibilities of microcapsules in drug delivery, some fundamental aspects are briefly reviewed.

  5. Magnetic targeted drug delivery

    Directory of Open Access Journals (Sweden)

    Timothy Wiedmann

    2009-10-01

    Full Text Available Lung cancer is the most common cause of death from cancer in both men and women. Treatment by intravenous or oral administration of chemotherapy agents results in serious and often treatment-limiting side effects. Delivery of drugs directly to the lung by inhalation of an aerosol holds the promise of achieving a higher concentration in the lung with lower blood levels. To further enhance the selective lung deposition, it may be possible to target deposition by using external magnetic fields to direct the delivery of drug coupled to magnetic particles. Moreover, alternating magnetic fields can be used to induce particle heating, which in turn controls the drug release rate with the appropriate thermal sensitive material.With this goal, superparamagetic nanoparticles (SPNP were prepared and characterized, and enhanced magnetic deposition was demonstrated in vitro and in vivo. SPNPs were also incorporated into a lipid-based/SPNP aerosol formulation, and drug release was shown to be controlled by thermal activation. Because of the inherent imaging potential of SPNPs, this use of nanotechnology offers the possibility of coupling the diagnosis of lung cancer to drug release, which perhaps will ultimately provide the “magic bullet” that Paul Ehrlich originally sought.

  6. ORGANOGELS: ADVANCED AND NOVEL DRUG DELIVERY SYSTEM

    Directory of Open Access Journals (Sweden)

    Garg Tarun

    2011-12-01

    Full Text Available Organogel, is a non crystalline, non-glassy thermoreversible (thermoplastic solid material and viscoelastic system, can be regarded as a semi-solid preparation which has an immobilized external apolar phase. The apolar phase gets immobilized within spaces of the three-dimensional networked structure formed due to the physical interactions amongst the self assembled structures of compounds regarded as gelators. Often, these systems are based on self-assembly of the structurant molecules. In general, organogels are thermodynamically stable in nature and have been explored as matrices for the delivery of bioactive agents. Organogels have potential for use in a number of applications, such as in pharmaceuticals, cosmetics, art conservation, and food. An example of formation of an undesired thermoreversible network is the occurrence of wax crystallization in petroleum. In the current manuscript, attempts have been made to understand the properties of organogels, various types of organogelators and some applications of the organogels in controlled delivery.

  7. 45 CFR 95.701 - Purpose and scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Purpose and scope of subpart. 95.701 Section 95.701 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GENERAL ADMINISTRATION-GRANT PROGRAMS (PUBLIC ASSISTANCE, MEDICAL ASSISTANCE AND STATE CHILDREN'S HEALTH INSURANCE...

  8. 26 CFR 31.3121(b)(14)-1 - Services in delivery or distribution of newspapers, shopping news, or magazines.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Services in delivery or distribution of... (Chapter 21, Internal Revenue Code of 1954) General Provisions § 31.3121(b)(14)-1 Services in delivery or... subsequent delivery or distribution, are excepted from employment. Thus, the services performed by...

  9. Drug delivery system and breast cancer cells

    Science.gov (United States)

    Colone, Marisa; Kaliappan, Subramanian; Calcabrini, Annarica; Tortora, Mariarosaria; Cavalieri, Francesca; Stringaro, Annarita

    2016-06-01

    Recently, nanomedicine has received increasing attention for its ability to improve the efficacy of cancer therapeutics. Nanosized polymer therapeutic agents offer the advantage of prolonged circulation in the blood stream, targeting to specific sites, improved efficacy and reduced side effects. In this way, local, controlled delivery of the drug will be achieved with the advantage of a high concentration of drug release at the target site while keeping the systemic concentration of the drug low, thus reducing side effects due to bioaccumulation. Various drug delivery systems such as nanoparticles, liposomes, microparticles and implants have been demonstrated to significantly enhance the preventive/therapeutic efficacy of many drugs by increasing their bioavailability and targetability. As these carriers significantly increase the therapeutic effect of drugs, their administration would become less cost effective in the near future. The purpose of our research work is to develop a delivery system for breast cancer cells using a microvector of drugs. These results highlight the potential uses of these responsive platforms suited for biomedical and pharmaceutical applications. At the request of all authors of the paper an updated version was published on 12 July 2016. The manuscript was prepared and submitted without Dr. Francesca Cavalieri's contribution and her name was added without her consent. Her name has been removed in the updated and re-published article.

  10. Rethinking Affordable Housing Delivery: An Analytical Insight

    Directory of Open Access Journals (Sweden)

    Olanrewaju Abdullateef

    2016-01-01

    Full Text Available Malaysia currently has a housing shortage of 12 million units. Towards the year 2020, this would require an annual supply of a minimum of 2 million homes. With the current production rate, the deficits will remain over the next 100 years. The crisis will lead to poor standards of living, un-affordable rental price, high mortgage payment, abandonment, and dilapidation of the existing housing stock. Lack of affordable housing is already a source of concern among many Malaysians. The middle and lower income earners spend more than 30% of their income on rent or for mortgage payment. Housing rent or mortgage is a basic need like foods, education, clothing and health. The government has introduced various measures to address the housing deficit. Despite these measures, the housing supply and distribution gaps continue to grow. To better understand the issues, there is a need to examine how the procurement planning in the affordable housing delivery supply chain and market is formulated, explore how cost of affordable housing would be reduced, identify the user value systems in affordable housing, and identify the criteria in the current regulatory framework? For these purposes, this paper reviews the relevant literature to reach preliminary findings on the stated issues. Among the factors found accounting for housing shortages, the overwhelming factors were that of poor policies, strategies, practice, management, and finance. The findings are meaningful in framing an affordable housing delivery model. It could also be useful to stakeholders involved in affordable housing delivery in Malaysia and elsewhere.

  11. Methods and metrics challenges of delivery-system research

    Directory of Open Access Journals (Sweden)

    Alexander Jeffrey A

    2012-03-01

    Full Text Available Abstract Background Many delivery-system interventions are fundamentally about change in social systems (both planned and unplanned. This systems perspective raises a number of methodological challenges for studying the effects of delivery-system change--particularly for answering questions related to whether the change will work under different conditions and how the change is integrated (or not into the operating context of the delivery system. Methods The purpose of this paper is to describe the methodological and measurement challenges posed by five key issues in delivery-system research: (1 modeling intervention context; (2 measuring readiness for change; (3 assessing intervention fidelity and sustainability; (4 assessing complex, multicomponent interventions; and (5 incorporating time in delivery-system models to discuss recommendations for addressing these issues. For each issue, we provide recommendations for how research may be designed and implemented to overcome these challenges. Results and conclusions We suggest that a more refined understanding of the mechanisms underlying delivery-system interventions (treatment theory and the ways in which outcomes for different classes of individuals change over time are fundamental starting points for capturing the heterogeneity in samples of individuals exposed to delivery-system interventions. To support the research recommendations outlined in this paper and to advance understanding of the "why" and "how" questions of delivery-system change and their effects, funding agencies should consider supporting studies with larger organizational sample sizes; longer duration; and nontraditional, mixed-methods designs. A version of this paper was prepared under contract with the Agency for Healthcare Research and Quality (AHRQ, US Department of Health and Human Services for presentation and discussion at a meeting on "The Challenge and Promise of Delivery System Research," held in Sterling, VA, on

  12. Document delivery services contrasting views

    CERN Document Server

    1999-01-01

    Design and maintain document delivery services that are ideal for academic patrons! In Document Delivery Services: Contrasting Views, you'll visit four university library systems to discover the considerations and challenges each library faced in bringing document delivery to its clientele. This book examines the questions about document delivery that are most pressing in the profession of library science. Despite their own unique experiences, you'll find common practices among all four?including planning, implementation of service, and evaluation of either user satisfaction and/or vendor per

  13. 28 CFR 90.12 - Eligible purposes.

    Science.gov (United States)

    2010-07-01

    ... improving delivery of victim services to racial, cultural, ethnic, and language minorities; providing... granted; and increasing reporting and reducing attrition rates for cases involving violent crimes...

  14. Improving IMRT delivery efficiency with reweighted L1-minimization for inverse planning

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hojin [Department of Radiation Oncology, Stanford University, Stanford, California 94305-5847 and Department of Electrical Engineering, Stanford University, Stanford, California 94305-9505 (United States); Becker, Stephen [Laboratoire Jacques-Louis Lions, Universite Pierre et Marie Curie, Paris 6, 75005 France (France); Lee, Rena; Lee, Soonhyouk [Department of Radiation Oncology, School of Medicine, Ewha Womans University, Seoul 158-710 (Korea, Republic of); Shin, Sukyoung [Medtronic CV RDN R and D, Santa Rosa, California 95403 (United States); Candes, Emmanuel [Department of Statistics, Stanford University, Stanford, California 94305-4065 (United States); Xing Lei; Li Ruijiang [Department of Radiation Oncology, Stanford University, Stanford, California 94305-5304 (United States)

    2013-07-15

    Purpose: This study presents an improved technique to further simplify the fluence-map in intensity modulated radiation therapy (IMRT) inverse planning, thereby reducing plan complexity and improving delivery efficiency, while maintaining the plan quality.Methods: First-order total-variation (TV) minimization (min.) based on L1-norm has been proposed to reduce the complexity of fluence-map in IMRT by generating sparse fluence-map variations. However, with stronger dose sparing to the critical structures, the inevitable increase in the fluence-map complexity can lead to inefficient dose delivery. Theoretically, L0-min. is the ideal solution for the sparse signal recovery problem, yet practically intractable due to its nonconvexity of the objective function. As an alternative, the authors use the iteratively reweighted L1-min. technique to incorporate the benefits of the L0-norm into the tractability of L1-min. The weight multiplied to each element is inversely related to the magnitude of the corresponding element, which is iteratively updated by the reweighting process. The proposed penalizing process combined with TV min. further improves sparsity in the fluence-map variations, hence ultimately enhancing the delivery efficiency. To validate the proposed method, this work compares three treatment plans obtained from quadratic min. (generally used in clinic IMRT), conventional TV min., and our proposed reweighted TV min. techniques, implemented by a large-scale L1-solver (template for first-order conic solver), for five patient clinical data. Criteria such as conformation number (CN), modulation index (MI), and estimated treatment time are employed to assess the relationship between the plan quality and delivery efficiency.Results: The proposed method yields simpler fluence-maps than the quadratic and conventional TV based techniques. To attain a given CN and dose sparing to the critical organs for 5 clinical cases, the proposed method reduces the number of segments

  15. Pectin-based colon-specific drug delivery

    Directory of Open Access Journals (Sweden)

    Shailendra Shukla

    2011-01-01

    Full Text Available Colon-specific drug delivery have a great importance in the delivery of drugs for the treatment of local colonic, as well as systemic diseases like Crohn′s disease, ulcerative colitis, colorectal cancer, amoebiasis, asthma, arthritis and inflammation which can be achieved by targeted delivery of drug to colon. Specific systemic absorption in the colon gave interesting possibilities for the delivery of protein and peptides. It contains relatively less proteolytic enzyme activities in the colon compared to the upper gastrointestinal tract (GIT. Recommended treatments included the administration of anti-inflammatory drugs, chemotherapeutic agents and antibiotics which must be released in the colon. Pectin is a naturally occurring polysaccharide has in recent years gained increasingly in importance in advance drug delivery. It was employed in pharmaceutical industry, health promotion and treatment. Owing to its gelling properties it has been used potentially as a carrier for drug delivery to the GIT, such as matrix tablets, gel beads, film-coated dose form. This review will discuss the important chemistry and general properties of pectin, its gel formation mechanism properties and its uses in novel drug delivery to the colon.

  16. Novel Polymeric Nanoparticles for Pulmonary Gene Delivery

    Science.gov (United States)

    Fields, Rachel Jennifer

    The lung is an important target for gene and drug therapy of many diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), tubuerculosis (TB) and lung cancer. In fact, the pulmonary route has been employed as a means of delivering drugs for centuries, dating back 4000 years to India where inhaled vapors were used for medicinal purpose. Currently, pulmonary administration of small, hydrophobic drugs leads to rapid local and systemic absorption. However, delivery of large biomacromolecules, such as therapeutic genes, has not yet been accomplished. Here, I test the hypothesis that a rationally engineered nanoparticle (NP) vector can improve delivery of large biomacromolecules. . In this dissertation I tested this hypothesis using a hybrid NP delivery system consisting of a blend of poly(lactic-co-glycolic acid) (PLGA) and a poly(beta-amino ester) (PBAE), a cationic polymer that is particularly useful for delivery of nucleic acids.. PBAE/PLGA nanoparticles (15% PBAE) loaded with plasmid DNA were surface modified with cell-penetrating peptides (CPPs) via a PEGylated phospholipid linker. This optimized NP formulation was able to induce substantial intracellular uptake and transfect lung epithelial cells in vitro while imparting minimal cellular toxicity. In order to determine the most effective method to deliver these NPs to the lung I used fluorescently labeled particles to study the biodistribution of particles after administration to the lung of mice via various administration routes. I determined that the intranasal route was most effective. I further investigated this route and determined that an average of 37.1 +/- 15.1 % of lung cells had NP association after 4hrs. I also investigated the association of particles with different lung cell types like macrophages and alveolar epithelial cells and determined that our best particle formulations associated with approximately 80% of both of these cell types. To demonstrate the ability of the

  17. Educational Purpose Cardiopulmonary Resuscitation Simulator

    Directory of Open Access Journals (Sweden)

    DRAGHICIU Nicolae

    2014-05-01

    Full Text Available Along with the development of computers and other sciences we can use in our personal projects complex structures built with microcontrollers. They miniaturise and simplify the final project, instead they depend/rely on the computer, through the programming of the microcontroller/s/them. This project presents the application of electronics in order to achieve a resuscitation mannequin for didactic purpose, using Arduino Prototyping Platform.

  18. NIIEFA accelerators for applied purposes

    Science.gov (United States)

    Vorogushin, M. F.; Strokach, A. P.; Filatov, O. G.

    2016-12-01

    Since the foundation of the institute, we have designed and delivered more than three hundred different accelerators to Russia and abroad: cyclotrons, linear accelerators, and neutron generators. The technical characteristics of our equipment makes it competitive on the international market. Here we present the application, main parameters, and status of accelerators manufactured by NIIEFA, as well as prospects for the development of electrophysical systems for applied purposes.

  19. Generalized product

    OpenAIRE

    Greco,Salvatore; Mesiar, Radko; Rindone, Fabio

    2014-01-01

    Aggregation functions on [0,1] with annihilator 0 can be seen as a generalized product on [0,1]. We study the generalized product on the bipolar scale [–1,1], stressing the axiomatic point of view. Based on newly introduced bipolar properties, such as the bipolar increasingness, bipolar unit element, bipolar idempotent element, several kinds of generalized bipolar product are introduced and studied. A special stress is put on bipolar semicopulas, bipolar quasi-copulas and bipolar copulas.

  20. Generalized product

    OpenAIRE

    Greco, Salvatore; Mesiar, Radko; Rindone, Fabio

    2014-01-01

    Aggregation functions on [0,1] with annihilator 0 can be seen as a generalized product on [0,1]. We study the generalized product on the bipolar scale [–1,1], stressing the axiomatic point of view. Based on newly introduced bipolar properties, such as the bipolar increasingness, bipolar unit element, bipolar idempotent element, several kinds of generalized bipolar product are introduced and studied. A special stress is put on bipolar semicopulas, bipolar quasi-copulas and bipolar copulas.

  1. Rhythmomimetic drug delivery

    CERN Document Server

    Calderer, M Carme; Siegel, Ronald A; Yao, Lingxing

    2015-01-01

    We present modeling, analysis and numerical simulation of a prototype glucose driven drug delivery device based on chemomechanical interactions and volume phase transitions in polyelectrolyte gels. The device consists of two fluid compartments, an external cell (I) mimicking the physiological environment, and a closed chamber (II), separated by a hydrogel membrane. Cell I, which is held at constant pH and ionic strength, provides a constant supply of glucose to cell II, and also serves as clearance station for reaction products. Cell II contains the drug to be delivered to the body, an enzyme that catalyzes conversion of glucose into hydrogen ions, and a piece of marble to remove excess hydrogen ions that would otherwise overwhelm the system. When the membrane is swollen, glucose flux into Cell II is high, leading to rapid production of hydrogen ions. However, the hydrogen ions are not immediately released to Cell I but react, instead, with the negatively charged carboxyl groups of the membrane, which collaps...

  2. Drug delivery goes supercritical

    Directory of Open Access Journals (Sweden)

    Patrick J. Ginty

    2005-08-01

    Full Text Available In the field of drug delivery, the ability to control the size, morphology, and release of drug particles is fundamental to good targeting, but is often hampered by harsh processing conditions or inadequate methods; likewise for the processing of polymeric controlled-release systems. However, the use of supercritical fluids such as supercritical CO2 (scCO2 has provided a ‘clean’ and effective alternative to traditional methods of drug and polymer processing. In particular, scCO2 has a number of unique properties that make it possible to process both bioactive molecules and amorphous polymers without using toxic organic solvents or elevated temperatures. Here, we review the positive impact that supercritical fluids have had on the micronization, encapsulation, and impregnation of molecules of interest to both the pharmaceutical and biotechnology industries.

  3. Alternating current electrospinning for preparation of fibrous drug delivery systems.

    Science.gov (United States)

    Balogh, Attila; Cselkó, Richárd; Démuth, Balázs; Verreck, Geert; Mensch, Jürgen; Marosi, György; Nagy, Zsombor Kristóf

    2015-11-10

    Alternating current electrospinning (ACES) was compared to direct current electrospinning (DCES) for the preparation of drug-loaded nanofibrous mats. It is generally considered that DCES is the solely technique to produce nanofibers using the electrostatic force from polymer solutions, however, less studied and also capable ACES provides further advantages such as increased specific productivities. A poorly water-soluble drug (carvedilol) was incorporated into the fibers based on three different polymeric matrices (an acid-soluble terpolymer (Eudragit(®) E), a base-soluble copolymer (Eudragit(®) L 100-55) and a nonionic homopolymer (polyvinylpyrrolidone K90)) to improve the dissolution of the weak base drug under different pH conditions. Morphology and fiber diameter evaluation showed similar electrospun fibers regardless the type of the high voltage and the major differences in feeding rates. The amorphous ACES and DCES fibers provided fast and total drug dissolutions in all cases. The presented results show that ACES can be a more feasible novel alternative to formulate fibers for drug delivery purposes.

  4. [Thought and application of traditional Chinese medicine multiple drug delivery system based on material basis component].

    Science.gov (United States)

    Sun, E; Jia, Xiaobin; Huang, Yang; Chen, Bin; Hu, Qin; Xiao, Wei

    2012-07-01

    To aim directly at the research status of Chinese drugs pharmaceutics, this study provides a new research idea "traditional Chinese medicine multiple drug delivery system based on material basis component". This thought according to whole concept, syndrome, and Chinese medicine characteristics of multi-component, multi-target, multi-effect. The premise of designing traditional Chinese medicine multiple drug delivery system is material basis component, and the purpose is to improve bioavailability. The example of multi-drug delivery system of tongmai micro-pellets is expounded for application. This new research model of Chinese drugs pharmaceutics provides new strategies and methods for the development of modern Chinese drug delivery systems.

  5. Hydrogen Delivery Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen.

  6. Decationized polyplexes for gene delivery

    NARCIS (Netherlands)

    Novo, L.; Mastrobattista, E.; Nostrum, van C.F.; Lammers, T.G.G.M.; Hennink, W.E.

    2015-01-01

    Gene therapy has received much attention in the field of drug delivery. Synthetic, nonviral gene delivery systems have gained increasing attention as vectors for gene therapy mainly due to a favorable immunogenicity profile and ease of manufacturing as compared to viral vectors. The great majority o

  7. Chemical Abstracts' Document Delivery Service.

    Science.gov (United States)

    Rollins, Stephen

    1984-01-01

    The Document Delivery Service offered by Chemical Abstracts is described in terms of the DIALORDER option on the Dialog information retrieval system, mail requests, and requests transmitted through OCLC's Interlibrary Loan system. Transmission costs, success rates, delivery rates, and other considerations in utilizing the service are included.…

  8. Birth delivery trauma and malocclusion.

    Science.gov (United States)

    Cattaneo, Ruggero; Monaco, Annalisa; Streni, Oriana; Serafino, Vittorio; Giannoni, Mario

    2005-01-01

    The aim of the investigation was to determine the dynamic of birth delivery and relate to dental occlusion among a group of adult subjects. The group studied was made up of 106 subjects (57 females and 49 males) referred for dental diagnosis and treatment. The average age was 26 with a range 22 to 30 years. In data collection and analysis the following were used as measures: dental occlusion (Angle Class I, II div 1, II div 2 and III) and type of delivery (normal, short, long, caesarean and other). Results showed that among 106 subjects 72 (68%) had malocclusion versus 34 (32%) with normal occlusion; 24 subjects (22.6%) have been normal delivery versus 82 (77.4%) with non-normal delivery. Class I is present in 34 subjects (32%), class II division 1 in 26 (24%), class II division 2 in 22. (20%), class III in 16 (14%), and 8 subjects (6%) fall in the section "other". Among 24 subjects with normal delivery 100% presented class I occlusion. However, among 82 subjects with non-normal delivery 10 subjects had a class I (12.2%) and the 72 (87.8%) had in the other classes, are distributed in the various subgroups of non-normal labor/delivery. None of the subjects with a malocclusion have a normal labor/delivery. Better understanding of the connections among osteopathic theory, craniosacral treatment and the outcomes upon dental occlusion, more rigorous evaluations are warranted.

  9. Development of wood fuel delivery logistics; Puupolttoaineiden hankintalogistiikan kehittaeminen

    Energy Technology Data Exchange (ETDEWEB)

    Laitinen, H.

    1996-12-31

    The main aim of the project is to model the energy wood business and total logistics in a certain large region. First, wood utilisation locations inside this area are examined; the most important ones are the wood processing factories, and the heating- and power plants. After that, wood potentials in the forests of the area are evaluated in sub-areas suitable in size and sufficiently detailed for further evaluations. For that purpose, the most valuable source data are forest management plans, up to ten years forward, on which basis the wood fuel potentials can be evaluated following sustainable development. In Finland there are extensive and detailed data bases storing forest information and it is possible to collect necessary data for a data base applicable to our calculations. In logistical sense it is important to know, by which delivery chains the economically best and desired results are achieved. The software prototype based on data base is modelled and developed at VTT Energy, for facilitating these planning activities. The starting point of the planning system in delivery logistics is the implementation of an easy tool for versatile planning so that with this tool model different delivery chains can be flexiblyed, create usage scenarios, make alternative examinations, and calculate impacts of different factors on energy wood amounts yielded and delivery costs. With planning system in delivery logistics we calculate production costs and amounts delivered to different utilisation locations. The system offers tools for definitions of utilisation locations, calculation parameters, and delivery chains

  10. Molecularly imprinted polymers as the future drug delivery devices.

    Science.gov (United States)

    Luliński, Piotr

    2013-01-01

    In recent years, the investigations of new drug delivery systems have been directed on the development of some "intelligent" drug delivery devices that are able to directly respond to the patient's individual needs. New drug delivery systems should maximize the efficiency of administrated therapeutic agents and improve the patient's quality of life. Introduction of the new drug delivery devices is an important scientific goal, which could be achieved by combining new technologies and intelligent biomaterials. Molecular imprinting technology has a high potential for the preparation of optimized drug delivery forms. Here, molecularly imprinted polymers (MIPs) are promising new materials for such purposes, but their application in this field is nowadays at a developing stage. In this review, the principles of molecular imprinting and the recognition-release mechanisms of polymeric matrices are discussed. The potential application of molecularly imprinted materials as the future drug delivery systems with various administering routes (transdermal, ocular or oral) are presented, and some future prospects for the imprinted polymers are outlined.

  11. Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.

    Science.gov (United States)

    Thompson, Marcelo Soto; Andersson-Engels, Stefan; Svanberg, Sune; Johansson, T; Palsson, Sara; Bendsoe, Niels; Derjabo, A; Kapostins, J; Stenram, Unne; Spigulis, J; Svanberg, Katarina

    2006-01-01

    To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.

  12. Direct leaf trajectory optimization for volumetric modulated arc therapy planning with sliding window delivery

    CERN Document Server

    Papp, Dávid

    2013-01-01

    We propose a novel optimization model for volumetric modulated arc therapy (VMAT) planning that directly optimizes deliverable leaf trajectories in the treatment plan optimization problem, and eliminates the need for a separate arc-sequencing step. In this model, a 360-degree arc is divided into a given number of arc segments in which the leaves move unidirectionally. This facilitates an algorithm that determines the optimal piecewise linear leaf trajectories for each arc segment, which are deliverable in a given treatment time. Multi-leaf collimator (MLC) constraints, including maximum leaf speed and interdigitation, are accounted for explicitly. The algorithm is customized to allow for VMAT delivery using constant gantry speed and dose rate, however, the algorithm generalizes to variable gantry speed if beneficial. We demonstrate the method for three different tumor sites: a head-and-neck case, a prostate case, and a paraspinal case. For that purpose, we first obtain a reference plan for intensity modulated...

  13. Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery

    Directory of Open Access Journals (Sweden)

    Chen CH

    2015-03-01

    Full Text Available Chun-Han Chen,1,2 Cheng-Chih Chang,1 Tsung-Hsien Shih,2 Ibrahim A Aljuffali,3 Ta-Sen Yeh,4,5 Jia-You Fang6–8 1Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, 2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; 3Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 4Department of Surgery, Chang Gung Memorial Hospital, 5School of Medicine, College of Medicine, 6Pharmaceutics Laboratory, Graduate Institute of Natural Products, 7Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, 8Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan Abstract: Roux-en-Y gastric bypass (RYGB is a popular surgery to reduce the body weight of obese patients. Although food intake is restricted by RYGB, drug absorption is also decreased. The purpose of this study was to develop novel self-nanoemulsifying drug delivery systems (SNEDDS for enhancing the oral delivery of silymarin, which has poor water solubility. The SNEDDS were characterized by size, zeta potential, droplet number, and morphology. A technique of RYGB was performed in Sprague-Dawley rats. SNEDDS were administered at a silymarin dose of 600 mg/kg in normal and RYGB rats for comparison with silymarin aqueous suspension and polyethylene glycol (PEG 400 solution. Plasma silibinin, the main active ingredient in silymarin, was chosen for estimating the pharmacokinetic parameters. SNEDDS diluted in simulated gastric fluid exhibited a droplet size of 190 nm with a spherical shape. The nanocarriers promoted silibinin availability via oral ingestion in RYGB rats by 2.5-fold and 1.5-fold compared to the suspension and PEG 400 solution, respectively. A significant double-peak concentration of silibinin was detected for RYGB rats receiving SNEDDS. Fluorescence

  14. Cluster Algorithm Special Purpose Processor

    Science.gov (United States)

    Talapov, A. L.; Shchur, L. N.; Andreichenko, V. B.; Dotsenko, Vl. S.

    We describe a Special Purpose Processor, realizing the Wolff algorithm in hardware, which is fast enough to study the critical behaviour of 2D Ising-like systems containing more than one million spins. The processor has been checked to produce correct results for a pure Ising model and for Ising model with random bonds. Its data also agree with the Nishimori exact results for spin glass. Only minor changes of the SPP design are necessary to increase the dimensionality and to take into account more complex systems such as Potts models.

  15. Cluster algorithm special purpose processor

    Energy Technology Data Exchange (ETDEWEB)

    Talapov, A.L.; Shchur, L.N.; Andreichenko, V.B.; Dotsenko, V.S. (Landau Inst. for Theoretical Physics, GSP-1 117940 Moscow V-334 (USSR))

    1992-08-10

    In this paper, the authors describe a Special Purpose Processor, realizing the Wolff algorithm in hardware, which is fast enough to study the critical behaviour of 2D Ising-like systems containing more than one million spins. The processor has been checked to produce correct results for a pure Ising model and for Ising model with random bonds. Its data also agree with the Nishimori exact results for spin glass. Only minor changes of the SPP design are necessary to increase the dimensionality and to take into account more complex systems such as Potts models.

  16. The effect of finite dose of ibuprofen on transdermal delivery / Johanna Margaretha Kilian

    OpenAIRE

    Kilian, Johanna Margaretha

    2012-01-01

    Transdermal drug delivery has the advantage over other routes of administration of avoiding the hepatic, first–pass metabolism that would result in better therapeutic efficacy, better patient medication compliance and reduced systemic side–effects (Kydoneieus & Berner, 1987:69). One disadvantage of this mode of drug delivery is the generally poor delivery of drugs through the skin. The intercellular lipid structure of the stratum corneum causes this membrane to be an excellent penetration bar...

  17. A new model for health care delivery

    Directory of Open Access Journals (Sweden)

    Kepros John P

    2009-04-01

    Full Text Available Abstract Background The health care delivery system in the United States is facing cost and quality pressures that will require fundamental changes to remain viable. The optimal structures of the relationships between the hospital, medical school, and physicians have not been determined but are likely to have a large impact on the future of healthcare delivery. Because it is generally agreed that academic medical centers will play a role in the sustainability of this future system, a fundamental understanding of the relative contributions of the stakeholders is important as well as creativity in developing novel strategies to achieve a shared vision. Discussion Core competencies of each of the stakeholders (the hospital, the medical school and the physicians must complement the others and should act synergistically. At the same time, the stakeholders should determine the common core values and should be able to make a meaningful contribution to the delivery of health care. Summary Health care needs to achieve higher quality and lower cost. Therefore, in order for physicians, medical schools, and hospitals to serve the needs of society in a gratifying way, there will need to be change. There needs to be more scientific and social advances. It is obvious that there is a real and urgent need for relationship building among the professionals whose duty it is to provide these services.

  18. Approaches for drug delivery with intracortical probes.

    Science.gov (United States)

    Spieth, Sven; Schumacher, Axel; Trenkle, Fabian; Brett, Olivia; Seidl, Karsten; Herwik, Stanislav; Kisban, Sebastian; Ruther, Patrick; Paul, Oliver; Aarts, Arno A A; Neves, Hercules P; Rich, P Dylan; Theobald, David E; Holtzman, Tahl; Dalley, Jeffrey W; Verhoef, Bram-Ernst; Janssen, Peter; Zengerle, Roland

    2014-08-01

    Intracortical microprobes allow the precise monitoring of electrical and chemical signaling and are widely used in neuroscience. Microelectromechanical system (MEMS) technologies have greatly enhanced the integration of multifunctional probes by facilitating the combination of multiple recording electrodes and drug delivery channels in a single probe. Depending on the neuroscientific application, various assembly strategies are required in addition to the microprobe fabrication itself. This paper summarizes recent advances in the fabrication and assembly of micromachined silicon probes for drug delivery achieved within the EU-funded research project NeuroProbes. The described fabrication process combines a two-wafer silicon bonding process with deep reactive ion etching, wafer grinding, and thin film patterning and offers a maximum in design flexibility. By applying this process, three general comb-like microprobe designs featuring up to four 8-mm-long shafts, cross sections from 150×200 to 250×250 µm², and different electrode and fluidic channel configurations are realized. Furthermore, we discuss the development and application of different probe assemblies for acute, semichronic, and chronic applications, including comb and array assemblies, floating microprobe arrays, as well as the complete drug delivery system NeuroMedicator for small animal research.

  19. Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes

    NARCIS (Netherlands)

    Pouwels, P.H.; Leer, R.J.; Shaw, M.; Heijne Den Bak-Glashouwer, M.J.; Tielen, F.D.; Smit, E.; Martinez, B.; Jore, J.; Conway, P.L.

    1998-01-01

    In vaccination programmes in which large numbers of subjects are involved, the oral route of administration is more convenient as compared to the more frequently used parenteral route. This is particularly relevant when vaccines are to be applied in less industrialized countries. Lactic acid bacteri

  20. Generalizing: The descriptive struggle

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, Ph.D.; Hon Ph.D.

    2006-11-01

    Full Text Available The literature is not kind to the use of descriptive generalizations. Authors struggle and struggle to find and rationalize a way to use them and then fail in spite of trying a myriad of work-arounds. And then we have Lincoln and Guba’s famous statement: “The only generalization is: there is no generalization” in referring to qualitative research. (op cit, p. 110 They are referring to routine QDA yielding extensive descriptions, but which tacitly include conceptual generalizations without any real thought of knowledge about them. In this chapter I wish to explore this struggle for the purpose of explaining that the various contra arguments to using descriptive generalizations DO NOT apply to the ease of using conceptual generalizations yielded in SGT and especially FGT. I will not argue for the use of descriptive generalization. I agree with Lincoln and Guba with respect to QDA, “the only generalization is: there is no generalization.” It is up to the QDA methodologists, of whom there are many; to continue the struggle and I wish them well.