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Sample records for gbm main detector-level

  1. GBM Accreting Pulsar Histories

    Data.gov (United States)

    National Aeronautics and Space Administration — For each source we plot the history of pulse frequency and pulsed flux measured using the Fermi Gamma-Ray Burst Monitor (GBM) NaI detectors. For these measurements...

  2. GBM Spectral Analysis

    Data.gov (United States)

    National Aeronautics and Space Administration — For GBM, input is daily or trigger CSPEC or CTIME file from Fermi archive and corresponding response file from our archive. For LAT, input is daily spectrum file and...

  3. GBM Response Matrix FITS Files

    Data.gov (United States)

    National Aeronautics and Space Administration — Time-dependent detector response matrices for each GBM detector covering the duration of every GBM flare. Needed in the spectral analysis software to relate observed...

  4. FERMIGTRIG - Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by one or more of the 14 GBM detectors (12 NaI and 2 BGO). Note that there are two Browse catalogs resulting from GBM...

  5. The GLAST Burst Monitor (GBM)

    OpenAIRE

    Lichti, G. G.; Briggs, M.S.; Diehl, R.; Fishman, G.; Georgii, R.; Kippen, R. M.; Kouveliotou, C.; Meegan, C.; Paciesas, W.; Preece, R.; Schoenfelder, V.; von Kienlin, A.

    2001-01-01

    The selection of the GLAST burst monitor (GBM) by NASA will allow the investigation of the relation between the keV and the MeV-GeV emission from gamma-ray bursts. The GBM consists of 12 NaI and 2 BGO crystals allowing a continuous measurement of the energy spectra of gamma-ray bursts from ~5 keV to \\~30 MeV. One feature of the GBM is its high time resolution for time-resolved gamma-ray spectroscopy. Moreover the arrangement of the NaI crystals allows a rapid on-board location (

  6. FERMIGBRST - Fermi GBM Burst Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by a subset of the 14 GBM detectors (12 NaI and 2 BGO) which have been classified as gamma-ray bursts (GRBs). Note that...

  7. The Fermi-GBM Gamma-Ray Burst Catalogs: The First Six Years

    Directory of Open Access Journals (Sweden)

    Bissaldi E.

    2017-01-01

    Full Text Available Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM has triggered and located on average approximately two gamma-ray bursts (GRBs every three days. Here we present the main results from the latest two catalogs provided by the Fermi-GBM science team, namely the third GBM GRB catalog [1] and the first GBM time-resolved spectral catalog [2]. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected bursts. It comprises 1405 triggers identified as GRBs. For each one, location and main characteristics of the prompt emission, the duration, the peak flux and the fluence are derived. The GBM time-resolved spectral catalog presents high-quality time-resolved spectral analysis with high temporal and spectral resolution of the brightest bursts observed by Fermi GBM in a shorter period than the former catalog, namely four years. It comprises 1491 spectra from 81 bursts. Distributions of parameters, statistics of the parameter populations, parameter-parameter and parameter-uncertainty correlations, and their exact values are obtained.

  8. Gamma-Ray Astrophysics NSSTC Fermi GBM

    Data.gov (United States)

    National Aeronautics and Space Administration — The Fermi Gamma-Ray Burst Monitor (GBM) is not a pointed or imaging instrument. To determine fluxes for known sources, we measure the change in the count rate...

  9. Magnetar Observations with Fermi/GBM

    Science.gov (United States)

    Kouveliotou, Chryssa

    2009-01-01

    NASA's Fermi Observatory was launched June 11, 2009; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. In the first year of operations we recorded emission from four magnetar sources; of these, only one was an old magnetar: SGR 1806+20. The other three detections were: SGR J0501+4516, newly discovered with Swift and extensively monitored with both Swift and GBM, SGR J1550-5418, a source originally classified as an Anomalous X-ray Pulsar (AXP) and a very recently discovered new source, SGR 0418+5729. I report below on the current status of the analyses efforts of the GBM data.

  10. Anti-GBM Disease in Pregnancy

    Directory of Open Access Journals (Sweden)

    Mohammed Muqeet Adnan MD

    2015-12-01

    Full Text Available Antiglomerular basement membrane (GBM disease presenting during pregnancy is uncommon. We present a case of a pregnant female who presented with acute renal failure requiring dialysis due to anti-GBM disease. She responded well to plasma exchange, high-dose steroids, and hemodialysis. Cyclophosphamide was discussed but not given at the patient’s request due to concerns for the well-being of the fetus. Unfortunately, she suffered a spontaneous abortion in her eighth week of pregnancy. Subsequently, she had progressive improvement in her renal function and became hemodialysis independent at 2 weeks after diagnosis. Her renal function returned to baseline 3 months after diagnosis. We present this case in detail and review the literature regarding anti-GBM disease in pregnancy.

  11. Three years of Transients with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2012-01-01

    The Gamma-ray Burst Monitor (GBM) is an all-sky monitoring instrument, sensitive between 8 keV and 40 MeV, with a primary objective of supporting the Large Area Telescope (LAT) in observations of Gamma-Ray Bursts (GRBs). Both instruments are part of the Fermi Gamma-ray Space Telescope. Together, the GBM and LAT instruments have provided ground-breaking measurements of GRBs that have, after 10 years of focus on GRB afterglows, inspired renewed interest in the prompt emission phase of GRBs and the physical mechanisms that fuel them. In addition to GRB science, GBM has made significant contributions to the astrophysics of galactic transient sources including long-term variations in the Crab nebula, spin state transitions in accretion powered pulsars, state transitions in black hole X-ray binaries, and unprecedented time-resolved spectral studies of soft gamma-ray repeater bursts. Closer to home, GBM also contributes to solar flare and terrestrial gamma flash science.

  12. TCGA Workshop: Genomics and Biology of Glioblastoma Multiforme (GBM) - TCGA

    Science.gov (United States)

    The National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) held a workshop entitled, “Genomics and Biology of Glioblastoma Multiforme (GBM),” to review the initial GBM data from the TCGA pilot project.

  13. GBM: a gamma-ray burst monitor for GLAST

    Science.gov (United States)

    Lichti, Giselher G.; Briggs, Michael S.; Diehl, Roland; Fishman, Gerald J.; Kippen, Richard M.; Kouveliotou, Chryssa; Meegan, Charles A.; Paciesas, William S.; Preece, Robert S.; Schoenfelder, Volker; von Kienlin, Andreas

    2003-03-01

    One of the scientific objectives of the GLAST mission is the study of gamma-ray bursts (GRBs) which will be measured by the Large-Area Telescope, the main instrument of GLAST, in the energy range from ~20 MeV to ~300 GeV. In order to extend the energy measurement towards lower energies a secondary instrument, the GLAST Burst Monitor (GBM) will measure GRBs from ~10 keV to ~25 MeV and will thus allow the investigation of the relation between the keV and the MeV-GeV emission from GRBs. The GBM consists of 12 circular NaI crystal discs and 2 cylindrical BGO crystals. The NaI crystals are optimized for gamma radiation from ~10 keV to ~1 MeV and the BGO crystals from ~150 keV to ~25 MeV. The NaI crystals are oriented in such a way that the measured relative counting rates allow a rapid determination of the position of a gamma-ray burst within a wide FoV of ~8.6 sr. This position will be communicated within seconds to the LAT which may then be reoriented to observe the long-lasting high-energy gamma-ray emission from GRBs. This will allow the exploration of the unknown aspects of the high-energy burst emission and their connection with the well-known low-energy emission. Another important feature of the GBM is its high time resolution of ~10 microseconds for time-resolved gamma-ray spectroscopy.

  14. High-energy transients with Fermi/GBM

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, David

    2012-10-09

    . Finally, I present the results of the search for untriggered GRBs in GBM data. This project focuses on GRBs which triggered Swift but not GBM although the GRBs came from positions above the horizon, with a favorable orientation to at least one GBM detector. The properties of these GRBs are then compared to the full sample of GBM GRBs published in the GBM spectral catalogue. Although designed mainly for GRB studies, GBM observes solar flares as well. In Chapter 3, I made use of the high temporal quality of GBM data to perform a detailed timing analysis of four solar flares. Contrary to recent claims in the literature, where quasiperiodic pulsations (QPPs) have been allegedly identified in the {gamma}-ray data of solar flares, I did not find any statistical significant signatures of such QPPs. When red-noise, an intrinsic source component, is accounted for, most of the claimed QPPs fall below the threshold of a significant detection. Moreover, I developed a new background estimation method for solar flares, called SOBER{sup 2} (SOlar Background Employing Relative Rates). This method uses the count rate of the complementary and shaded BGO detector as an a priori information to determine the background fluctuations for the Sun-facing BGO detector. Such a method is especially useful and beneficial for solar flares because they are usually of very long duration and the standard GBM background subtraction fails in such cases. Finally, in Chapter 4, I present the log-parabolic model which I used to fit the spectra of SGR bursts. Even though the spectra of the latter are usually and preferentially fit by a sum of two blackbodies in the literature, I show that the log-parabolic model fits the data as least as well as the double blackbody function. Additionally, the log-parabolic model is based on a strong underlying physical mechanism, i.e. second order Fermi acceleration, which gives it even more credibility.

  15. The 3rd Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    CERN Document Server

    Bhat, P Narayana; von Kienlin, Andreas; Paciesas, William S; Briggs, Michael S; Burgess, J Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H; Collazzi, Andrew C; Connaughto, Valerie; Diekmann, Anne M; Fitzpatrick, Gerard; Gibby, Melissa H; Giles, Misty M; Goldstein, Adam M; Greiner, Jochen; Jenke, Peter A; Kippen, R Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D; Roberts, Oliver J; Sparke, Linda S; Stanbro, Matthew; Veres, Peter; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-01-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two gamma-ray bursts (GRB) every three days. Here we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years, through the middle of July 2014. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300~keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBM's low-energy NaI(Tl) detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRB...

  16. The 2nd Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    CERN Document Server

    von Kienlin, Andreas; Paciesas, William S; Bhat, P N; Bissaldi, Elisabetta; Briggs, Michael S; Burgess, J Michael; Byrne, David; Chaplin, Vandiver; Cleveland, William; Connaughton, Valerie; Collazzi, Andrew C; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J; Kouveliotou, Chryssa; Layden, Emily; McBreen, Sheila; McGlynn, Sinead; Pelassa, Veronique; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung

    2014-01-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50 - 300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10 - 1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM sci...

  17. THE SECOND FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST FOUR YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Von Kienlin, Andreas; Greiner, Jochen; Gruber, David [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Meegan, Charles A.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam [University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Paciesas, William S.; Cleveland, William [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Bissaldi, Elisabetta [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Byrne, David; Fitzpatrick, Gerard; Foley, Suzanne [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Collazzi, Andrew C. [Astrophysics Office, ZP 12, NASA-Marshall Space Flight Center, Huntsville, AL 35812 (United States); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., Huntsville, AL 35806 (United States); Guiriec, Sylvain [NASA-Goddard Space Flight Center, Greenbelt, MD 20771 (United States); and others

    2014-03-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  18. The Third Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    Science.gov (United States)

    Narayana Bhat, P.; Meegan, Charles A.; von Kienlin, Andreas; Paciesas, William S.; Briggs, Michael S.; Burgess, J. Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H.; Collazzi, Andrew C.; Connaughton, Valerie; Diekmann, Anne M.; Fitzpatrick, Gerard; Gibby, Melissa H.; Giles, Misty M.; Goldstein, Adam M.; Greiner, Jochen; Jenke, Peter A.; Kippen, R. Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D.; Roberts, Oliver J.; Sparke, Linda S.; Stanbro, Matthew; Veres, Péter; Wilson-Hodge, Colleen A.; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-04-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two γ-ray bursts (GRBs) every three days. Here, we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years through the middle of 2014 July. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM-detected GRBs. For each GRB, the location and main characteristics of the prompt emission, the duration, peak flux, and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10 to 1000 keV, exploiting the full energy range of GBM's low-energy [Nai[Tl)] detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRBs are better fit by a two-component model with short-hard and long-soft bursts than by a model with three components. Furthermore, information is provided on the settings and modifications of the triggering criteria and exceptional operational conditions during years five and six in the mission. This third catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  19. Diagnosis and classification of Goodpasture's disease (anti-GBM).

    Science.gov (United States)

    Hellmark, Thomas; Segelmark, Mårten

    2014-01-01

    Goodpasture's disease or anti-glomerular basement membrane disease (anti-GBM-disease) is included among immune complex small vessel vasculitides. The definition of anti-GBM disease is a vasculitis affecting glomerular capillaries, pulmonary capillaries, or both, with GBM deposition of anti-GBM autoantibodies. The disease is a prototype of autoimmune disease, where the patients develop autoantibodies that bind to the basement membranes and activate the classical pathway of the complement system, which start a neutrophil dependent inflammation. The diagnosis of anti-GBM disease relies on the detection of anti-GBM antibodies in conjunction with glomerulonephritis and/or alveolitis. Overt clinical symptoms are most prominent in the glomeruli where the inflammation usually results in a severe rapidly progressive glomerulonephritis. Despite modern treatment less than one third of the patients survive with a preserved kidney function after 6 months follow-up. Frequencies vary from 0.5 to 1 cases per million inhabitants per year and there is a strong genetic linkage to HLA-DRB1(∗)1501 and DRB1(∗)1502. Essentially, anti-GBM disease is now a preferred term for what was earlier called Goodpasture's syndrome or Goodpasture's disease; anti-GBM disease is now classified as small vessel vasculitis caused by in situ immune complex formation; the diagnosis relies on the detection of anti-GBM in tissues or circulation in conjunction with alveolar or glomerular disease; therapy is effective only when detected at an early stage, making a high degree of awareness necessary to find these rare cases; 20-35% have anti-GBM and MPO-ANCA simultaneously, which necessitates testing for anti-GBM whenever acute test for ANCA is ordered in patients with renal disease. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. All-Sky Monitoring of Variable Sources with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Cherry, Michael L.; Case, Gary L.; Camero-Arranz, Ascension; Chaplin, Vandiver; Connaughton, Valerie; Finger, Mark H.; Jenke, Pater; Rodi, James C.; Baumgartner, Wayne H.; Beklen, Elif; Bhat, P. Narayana; Briggs, Michael S.; Gehrels, Neil; Greiner, Jochen; Jahoda, Keith; Kippen, R. Marc; Kouveliotou, Chryssa; Krimm, Hans A.; Kuulkers, Erik; Lund, Niels; Meegan, Charles A.; Natalucci, Lorenzo; Paciesas, William S.; Preece, Robert

    2011-01-01

    This slide presentation reviews the monitoring of variable sources with the Fermi Gamma Ray Burst Monitor (GBM). It reviews the use of the Earth Occultation technique, the observations of the Crab Nebula with the GBM, and the comparison with other satellite's observations. The instruments on board the four satellites indicate a decline in the Crab from 2008-2010.

  1. Comparative analyses of gene copy number and mRNA expression in GBM tumors and GBM xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Hodgson, J. Graeme; Yeh, Ru-Fang; Ray, Amrita; Wang, Nicholas J.; Smirnov, Ivan; Yu, Mamie; Hariono, Sujatmi; Silber, Joachim; Feiler, Heidi S.; Gray, Joe W.; Spellman, Paul T.; Vandenberg, Scott R.; Berger, Mitchel S.; James, C. David

    2009-04-03

    Development of model systems that recapitulate the molecular heterogeneity observed among glioblastoma multiforme (GBM) tumors will expedite the testing of targeted molecular therapeutic strategies for GBM treatment. In this study, we profiled DNA copy number and mRNA expression in 21 independent GBM tumor lines maintained as subcutaneous xenografts (GBMX), and compared GBMX molecular signatures to those observed in GBM clinical specimens derived from the Cancer Genome Atlas (TCGA). The predominant copy number signature in both tumor groups was defined by chromosome-7 gain/chromosome-10 loss, a poor-prognosis genetic signature. We also observed, at frequencies similar to that detected in TCGA GBM tumors, genomic amplification and overexpression of known GBM oncogenes, such as EGFR, MDM2, CDK6, and MYCN, and novel genes, including NUP107, SLC35E3, MMP1, MMP13, and DDX1. The transcriptional signature of GBMX tumors, which was stable over multiple subcutaneous passages, was defined by overexpression of genes involved in M phase, DNA replication, and chromosome organization (MRC) and was highly similar to the poor-prognosis mitosis and cell-cycle module (MCM) in GBM. Assessment of gene expression in TCGA-derived GBMs revealed overexpression of MRC cancer genes AURKB, BIRC5, CCNB1, CCNB2, CDC2, CDK2, and FOXM1, which form a transcriptional network important for G2/M progression and/or checkpoint activation. Our study supports propagation of GBM tumors as subcutaneous xenografts as a useful approach for sustaining key molecular characteristics of patient tumors, and highlights therapeutic opportunities conferred by this GBMX tumor panel for testing targeted therapeutic strategies for GBM treatment.

  2. Fully automatic GBM segmentation in the TCGA-GBM dataset: Prognosis and correlation with VASARI features.

    Science.gov (United States)

    Rios Velazquez, Emmanuel; Meier, Raphael; Dunn, William D; Alexander, Brian; Wiest, Roland; Bauer, Stefan; Gutman, David A; Reyes, Mauricio; Aerts, Hugo J W L

    2015-11-18

    Reproducible definition and quantification of imaging biomarkers is essential. We evaluated a fully automatic MR-based segmentation method by comparing it to manually defined sub-volumes by experienced radiologists in the TCGA-GBM dataset, in terms of sub-volume prognosis and association with VASARI features. MRI sets of 109 GBM patients were downloaded from the Cancer Imaging archive. GBM sub-compartments were defined manually and automatically using the Brain Tumor Image Analysis (BraTumIA). Spearman's correlation was used to evaluate the agreement with VASARI features. Prognostic significance was assessed using the C-index. Auto-segmented sub-volumes showed moderate to high agreement with manually delineated volumes (range (r): 0.4 - 0.86). Also, the auto and manual volumes showed similar correlation with VASARI features (auto r = 0.35, 0.43 and 0.36; manual r = 0.17, 0.67, 0.41, for contrast-enhancing, necrosis and edema, respectively). The auto-segmented contrast-enhancing volume and post-contrast abnormal volume showed the highest AUC (0.66, CI: 0.55-0.77 and 0.65, CI: 0.54-0.76), comparable to manually defined volumes (0.64, CI: 0.53-0.75 and 0.63, CI: 0.52-0.74, respectively). BraTumIA and manual tumor sub-compartments showed comparable performance in terms of prognosis and correlation with VASARI features. This method can enable more reproducible definition and quantification of imaging based biomarkers and has potential in high-throughput medical imaging research.

  3. Time-Domain Astronomy with the Fermi GBM

    Science.gov (United States)

    Hui, C. M.

    2017-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) is an all-sky monitoring instrument sensitive to energies from 8 keV to 40 MeV. Over the past 8 years of operation, the GBM has detected over 240 gamma-ray bursts per year and provided timely GCN notices with localization to few-degree accuracy for follow-up observations. In addition to GRBs, Galactic transients, solar flares, and terrestrial gamma-ray flashes have also been observed. In recent years we have also been searching the continuous GBM data for electromagnetic counterpart to astrophysical neutrinos and gravitational wave events, as these are believed to be associated with gamma-ray bursts. With continuous data downlink every few hours and a temporal resolution of 2 microseconds, GBM is well suited for observing transients and supporting EM follow-up in the era of multi-messenger astronomy.

  4. Magnetar Observations in the Swift-Fermi/GBM Era

    Science.gov (United States)

    Kouveliotou, Chryssa

    2010-01-01

    NASA's Fermi Observatory was launched June 11, 2008; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. Since then, and against all odds, GBM recorded over 600 bursts from 4 SGRs. Of these four sources, only one was an old magnetar: SGR J1806+20. SGR J0501+4516, was discovered with Swift and extensively monitored with GBM. A source originally classified as AXP 1E1547.0-5408 exhibited SGR-like bursting behavior and we reclassified it as SGR J1550-5418. Finally, GBM discovered SGR J0418+5729 on 2009 June. Finally, on March 2010, a third new magnetar was discovered with Swift, SGR J1833-0832. I report below on the current status of the field and on several results combining multi-satellite and ground-based data

  5. Anti-GBM disease and renal vein thrombosis.

    Science.gov (United States)

    Bailey, Phillippa; Sarfraz, Farook; Ravanan, Rommel

    2011-11-15

    A 23-year-old female who presented with advanced renal failure was subsequently diagnosed with renal vein thrombosis and antiglomerular basement membrane (GBM) antibody disease. A previous case of renal vein thrombosis has been reported in association with anti-GBM disease, but to our knowledge, this is the first reported case in which the presentation of anti-GBM disease and renal vein thrombosis was concurrent. Further study is essential to understand if the association of anti-GBM disease and renal vein thrombosis as seen in our case was pure coincidence or is in fact occurs more frequently. It may be that the dual diagnosis is not made as establishing one sufficient diagnosis for renal failure may halt further investigations for additional diagnoses.

  6. GBM heterogeneity characterization by radiomic analysis of phenotype anatomical planes

    Science.gov (United States)

    Chaddad, Ahmad; Desrosiers, Christian; Toews, Matthew

    2016-03-01

    Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system, characterized among other traits by rapid metastatis. Three tissue phenotypes closely associated with GBMs, namely, necrosis (N), contrast enhancement (CE), and edema/invasion (E), exhibit characteristic patterns of texture heterogeneity in magnetic resonance images (MRI). In this study, we propose a novel model to characterize GBM tissue phenotypes using gray level co-occurrence matrices (GLCM) in three anatomical planes. The GLCM encodes local image patches in terms of informative, orientation-invariant texture descriptors, which are used here to sub-classify GBM tissue phenotypes. Experiments demonstrate the model on MRI data of 41 GBM patients, obtained from the cancer genome atlas (TCGA). Intensity-based automatic image registration is applied to align corresponding pairs of fixed T1˗weighted (T1˗WI) post-contrast and fluid attenuated inversion recovery (FLAIR) images. GBM tissue regions are then segmented using the 3D Slicer tool. Texture features are computed from 12 quantifier functions operating on GLCM descriptors, that are generated from MRI intensities within segmented GBM tissue regions. Various classifier models are used to evaluate the effectiveness of texture features for discriminating between GBM phenotypes. Results based on T1-WI scans showed a phenotype classification accuracy of over 88.14%, a sensitivity of 85.37% and a specificity of 96.1%, using the linear discriminant analysis (LDA) classifier. This model has the potential to provide important characteristics of tumors, which can be used for the sub-classification of GBM phenotypes.

  7. The Successful Synergy of Swift and Fermi/GBM in Magnetars

    Science.gov (United States)

    Kouveliotou, Chryssa

    2011-01-01

    The magnetar rate of discovery has increased dramatically in the last decade. Five sources were discovered in the last three years alone as a result of the very efficient synergy among three X- and .gamma-ray instruments on NASA satellites: the Swift/Burst Alert Telescope (BAT), the Fermi/Gamma ray Burst Monitor (GBM), and the Rossi X-Ray Timing Explorer; RXTE/Proportional Counter Array (PCA). To date, there are approx. 25 magnetar candidates, of which two are (one each) in the Large and Small Magellanic Cloud and the rest reside on the Galactic plane of our Milky Way. I will discuss here the main properties of the Magnetar Population and the common projects that can be achieved with the synergy of Swift and GBM.

  8. Visualizing molecular profiles of glioblastoma with GBM-BioDP.

    Directory of Open Access Journals (Sweden)

    Orieta Celiku

    Full Text Available Validation of clinical biomarkers and response to therapy is a challenging topic in cancer research. An important source of information for virtual validation is the datasets generated from multi-center cancer research projects such as The Cancer Genome Atlas project (TCGA. These data enable investigation of genetic and epigenetic changes responsible for cancer onset and progression, response to cancer therapies, and discovery of the molecular profiles of various cancers. However, these analyses often require bulk download of data and substantial bioinformatics expertise, which can be intimidating for investigators. Here, we report on the development of a new resource available to scientists: a data base called Glioblastoma Bio Discovery Portal (GBM-BioDP. GBM-BioDP is a free web-accessible resource that hosts a subset of the glioblastoma TCGA data and enables an intuitive query and interactive display of the resultant data. This resource provides visualization tools for the exploration of gene, miRNA, and protein expression, differential expression within the subtypes of GBM, and potential associations with clinical outcome, which are useful for virtual biological validation. The tool may also enable generation of hypotheses on how therapies impact GBM molecular profiles, which can help in personalization of treatment for optimal outcome. The resource can be accessed freely at http://gbm-biodp.nci.nih.gov (a tutorial is included.

  9. THE FIVE YEAR FERMI/GBM MAGNETAR BURST CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Collazzi, A. C. [SciTec, Inc., 100 Wall Street, Princeton, NJ 08540 (United States); Kouveliotou, C.; Horst, A. J. van der; Younes, G. A. [Department of Physics, The George Washington University, 725 21st Street NW, Washington, DC 20052 (United States); Kaneko, Y.; Göğüş, E. [Sabancı University, Orhanlı-Tuzla, İstanbul 34956 (Turkey); Lin, L. [François Arago Centre, APC, 10 rue Alice Domon et Léonie Duquet, F-75205 Paris (France); Granot, J. [Department of Natural Sciences, The Open University of Israel, 1 University Road, P.O. Box 808, Raanana 43537 (Israel); Finger, M. H. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Chaplin, V. L. [School of Medicine, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 (United States); Huppenkothen, D. [Center for Data Science, New York University, 726 Broadway, 7th Floor, New York, NY 10003 (United States); Watts, A. L. [Anton Pannekoek Institute, University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Kienlin, A. von [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Baring, M. G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Gruber, D. [Planetarium Südtirol, Gummer 5, I-39053 Karneid (Italy); Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Gibby, M. H., E-mail: acollazzi@scitec.com [Jacobs Technology, Inc., Huntsville, AL (United States); and others

    2015-05-15

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550–5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  10. Fermi GBM Observations of LIGO Gravitational Wave event GW150914

    CERN Document Server

    Connaughton, V; Goldstein, A; Briggs, M S; Zhang, B -B; Hui, C M; Jenke, P; Racusin, J; Wilson-Hodge, C A; Bhat, P N; Cleveland, W; Fitzpatrick, G; Giles, M M; Gibby, M H; Greiner, J; von Kienlin, A; Kippen, R M; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O; Sparke, L; Stanbro, M; Toelge, K; Veres, P; Yu, H -F; authors, other

    2016-01-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO)event GW150914 reveal the presence of a weak transient source above 50 keV, 0.4 s after the GW event was detected, with a false alarm probability of 0.0022. This weak transient lasting 1 s does not appear connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event suggest it is a weak short Gamma-Ray Burst arriving at a large angle to the direction in which Fermi was pointing, where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, this electromagnetic signal from a stellar mass black hole binary merger is unexpected....

  11. The Five Year Fermi/GBM Magnetar Burst Catalog

    NARCIS (Netherlands)

    A.C. Collazzi; C. Kouveliotou; A.J. van der Horst; G.A. Younes; Y. Kaneko; E. Göğüş; L. Lin; J. Granot; M.H. Finger; V.L. Chaplin; D. Huppenkothen; A.L. Watts; A. von Kienlin; M.G. Baring; D. Gruber; P.N. Bhat; M.H. Gibby; N. Gehrels; J. Mcenery; M. van der Klis; R.A.M.J. Wijers

    2015-01-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present

  12. Recruitment of bone marrow derived cells during anti-angiogenic therapy in GBM : Bone marrow derived cell in GBM

    NARCIS (Netherlands)

    Boer, Jennifer C.; Walenkamp, Annemiek M. E.; den Dunnen, Wilfred F. A.

    2014-01-01

    Glioblastoma (GBM) is a highly vascular tumor characterized by rapid and invasive tumor growth, followed by oxygen depletion, hypoxia and neovascularization, which generate a network of disorganized, tortuous and permeable vessels. Recruitment of bone marrow derived cells (BMDC) is crucial for vascu

  13. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    Science.gov (United States)

    Hurley, K.; Briggs, M.; Connaughton, V.; Meegan, C.; von Kienlin, A.; Rau, A.; Zhang, X.; Golenetskii, S.; Aptekar, R.; Mazets, E.; Pal'shin, V.; Fredericks, D.; Barthelmy, S.; Cummings, J.; Gehrels, N.; Krimm, H. A.; Mitrofanov, I. G.; Golovin, D.; Litvak, M. L.; Sanin, A. B.; Boynton, W.; Fellows, C.; Harshman, K.; Starr, R.; Goldsten, J.

    2012-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  14. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    CERN Document Server

    Hurley, K; Connaughton, V; Meegan, C; von Kienlin, A; Rau, A; Zhang, X; Golenetskii, S; Aptekar, R; Mazets, E; Pal'shin, V; Frederiks, D; Barthelmy, S; Cline, T; Cummings, J; Gehrels, N; Krimm, H A; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Starr, R; Smith, D M; Hajdas, W; Yamaoka, K; Ohno, M; Fukazawa, Y; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Palmer, D M; Goldsten, J; Del Monte, E; Feroci, M; Marisaldi, M

    2011-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  15. AI-05IMPACT OF GBM MICROENVIRONMENT ON EXPRESSION PROFILE OF BONE MARROW DERIVED PROGENITOR CELLS

    OpenAIRE

    Burrell, Kelly; Singh, Sanjay; Agnihotri, Sameer; Hill, Richard; Aldape, Kenneth; Zadeh, Gelareh

    2014-01-01

    We have recently shown that bone marrow derived cells (BMDC) provide a distinct tumor region dependent contribution to glioblastoma multiforme (GBM) neovascularization. The influence of GBM microenvironment on differentiation and modulation of expression factors by BMDC however remains unknown. In this study we establish the differential expression profile of BMDC as a consequence of recruitment and interaction with the GBM microenvironment and in response to radiation (RTx) and anti-angiogen...

  16. A possible association of partial lipodystrophy with anti-GBM nephritis (Goodpasture's syndrome).

    OpenAIRE

    Blake, D. R.; Rashid, H.; McHugh, M.; Morley, A. R.

    1980-01-01

    Partial lipodystrophy is known to be associated with mesangiocapillary glomerulonephritis. A case is described of a possible association of partial lipodystrophy with anti-GBM nephritis (Goodpasture's syndrome).

  17. Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant.

    Science.gov (United States)

    Ali, Saad; Joseph, Nancy M; Perry, Arie; Barajas, Ramon F; Cha, Soonmee

    2014-09-01

    Glioblastoma (GBM) with primitive neuroectodermal tumor (PNET)-like (GBM-PNET) components is a rare variant of GBM. Recent studies describe PNET-like clinical behavior in these patients-with significantly increased propensity for CSF dissemination and a benefit of "PNET-like" chemotherapy. The imaging appearance of GBM-PNET is not well-described and given areas of marked cellularity in the PNET components one might expect significantly reduced diffusion on MRI. The purpose of this study is to quantitatively evaluate the diffusion characteristics in GBM-PNET and compare them with conventional GBMs. Nine patients with surgical specimens yielding GBM-PNET were identified from the UCSF Pathology files. MR images of these patients were reviewed retrospectively. DWI (diffusion-weighted imaging) sequences were analyzed with multiple regions of interests placed within the tumor, and ADC (apparent diffusion coefficient) values were measured. Results were compared to previously published ADC values in pathology-proven conventional GBM cases from our institution. Reduced ADC was seen in GBM-PNET (mean 581 × 10(-6) mm(2)/s, range 338-817) compared to previously published mean of 1,030 × 10(-6) mm(2)/s in the enhancing components of conventional GBMs. We report substantially reduced ADC values in GBM-PNETs compared to conventional GBMs. If demonstrated in a larger sample, when areas of marked reduced diffusion are seen in a suspected GBM, MRI may appropriately direct tissue sampling and can advocate a thorough search for PNET-like components on histopathology. These patients may have a higher chance of developing CSF dissemination and may benefit from "PNET-like" platinum-based chemotherapy.

  18. THE FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Paciesas, William S.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam; Guiriec, Sylvain [Center for Space Plasma and Aeronomic Research, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, Charles A.; Van der Horst, Alexander J. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Von Kienlin, Andreas; Diehl, Roland; Foley, Suzanne; Greiner, Jochen; Gruber, David [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Bissaldi, Elisabetta [Institute of Astro and Particle Physics, University Innsbruck, Technikerstrasse 25, 6176 Innsbruck (Austria); Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., 1525 Perimeter Pkwy NW, Huntsville, AL 35806 (United States); and others

    2012-03-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered GRBs, including their locations, durations, peak flux, and fluence. This catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  19. Computer Implementation of a New Therapeutic Model for GBM Tumor

    Directory of Open Access Journals (Sweden)

    Ali Jamali Nazari

    2014-01-01

    Full Text Available Modeling the tumor behavior in the host organ as function of time and radiation dose has been a major study in the previous decades. Here the effort in estimation of cancerous and normal cell proliferation and growth in glioblastoma multiform (GBM tumor is presented. This paper introduces a new mathematical model in the form of differential equation of tumor growth. The model contains dose delivery amount in the treatment scheme as an input term. It also can be utilized to optimize the treatment process in order to increase the patient survival period. Gene expression programming (GEP as a new concept is used for estimating this model. The LQ model has also been applied to GEP as an initial value, causing acceleration and improvement of the algorithm estimation. The model shows the number of the tumor and normal brain cells during the treatment process using the status of normal and cancerous cells in the initiation of treatment, the timing and amount of dose delivery to the patient, and a coefficient that describes the brain condition. A critical level is defined for normal cell when the patient’s death occurs. In the end the model has been verified by clinical data obtained from previous accepted formulae and some of our experimental resources. The proposed model helps to predict tumor growth during treatment process in which further treatment processes can be controlled.

  20. Fermi/GBM Observations of SGR J0501+4516

    Science.gov (United States)

    Lin, Lin; Kouveliotou, Chryssa; van der Horst, Alexander J.

    2011-08-01

    The magnetar candidate SGR J0501+4516 was discovered when it became active for about 13 days from August 22 to September 3, 2008. During this period, the Gamma-ray Burst Monitor (GBM) onboard Fermi detected over 30 bursts. We present here our results on the temporal and spectral analysis of the 29 bursts for which high spectral and time resolution data is available. We find that the T90 durations of the bursts follow a log-normal distribution with a mean value of ~123 ms. We fit the time-integrated spectrum of each burst with several models: a black body function, optically thin thermal brehmsstrahlung, a power law with an exponential cut-off, two black body functions, and the combination of a black body and a power law. We discuss our results in the context of the spectral properties of other magnetar bursts and we also present some correlations between the spectral parameters of the best fit models for all bursts. Finally, we present the results of our time-resolved spectral analysis of the five brightest bursts and discuss how they compare with our time-integrated results.

  1. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells

    Directory of Open Access Journals (Sweden)

    Tzuu-Yuan Huang

    2012-01-01

    Full Text Available Demethoxycurcumin (DMC; a curcumin-related demethoxy compound has been recently shown to display antioxidant and antitumor activities. It has also produced a potent chemopreventive action against cancer. In the present study, the antiproliferation (using the MTT assay, DMC was found to have cytotoxic activities against GBM 8401 cell with IC50 values at 22.71 μM and induced apoptosis effects of DMC have been investigated in human brain malignant glioma GBM 8401 cells. We have studied the mitochondrial membrane potential (MMP, DNA fragmentation, caspase activation, and NF-κB transcriptional factor activity. By these approaches, our results indicated that DMC has produced an inhibition of cell proliferation as well as the activation of apoptosis in GBM 8401 cells. Both effects were observed to increase in proportion with the dosage of DMC treatment, and the apoptosis was induced by DMC in human brain malignant glioma GBM 8401 cells via mitochondria- and caspase-dependent pathways.

  2. Crescentic Glomerulonephritis with Anti-GBM and p-ANCA Antibodies

    Directory of Open Access Journals (Sweden)

    Tariq Javed

    2012-01-01

    Full Text Available We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. Patients with dual antibodies are considered to be a vasculitis-variant of anti-GBM antibody nephritis. These patients may have atypical presentation and it may delay diagnosis and treatment. Recurrence rate is higher in these patients. We reviewed the literature of cases and studies on cresenteric glomerulonephritis with anti-GBM and p-ANCA positive patients. We recommend that patients suspected with pulmonary-renal syndrome should be checked for anti-GBM and p-ANCA antibodies, should undergo renal biopsy and should should have close long term follow up to watch for recurrence.

  3. Dismantling of the EB experiment: Experimental research on the retrieved GBM and bentonite blocks

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jiang-Feng, E-mail: jeafliu@hotmail.com [State Key Laboratory for Geomchanics & Deep Underground Engineering, and School of Mechanics and Civil Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116 (China); Laboratoire de Méchanique de Lille (LML), and École Centrale de Lille, BP 48, F-59651 Villeneuve d’Ascq Cedex (France); Skoczylas, Frédéric [Laboratoire de Méchanique de Lille (LML), and École Centrale de Lille, BP 48, F-59651 Villeneuve d’Ascq Cedex (France); Talandier, Jean [ANDRA, 1-7 rue Jean Monnet, 92298 Châtenay-Malabry Cedex (France); Pu, Hai [State Key Laboratory for Geomchanics & Deep Underground Engineering, and School of Mechanics and Civil Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116 (China)

    2016-04-15

    Graphical abstract: - Highlights: • We present a demonstration of a new concept of HLW (high-level waste) repositories. • The hydro-mechanical characteristics of GBM and blocks were determined. • The water retention curves (WRCs) of GBM and blocks were presented. • The effective gas permeability of the GBM and blocks were measured. • The homogeneity of the GBM and blocks were investigated. - Abstract: The Engineered Barrier Emplacement Experiment in Opalinus Clay (EB experiment) was a full-scale test for the demonstration of a new concept of high-level waste (HLW) repositories in horizontal drifts in the Opalinus Clay formation. After 10.5 years of hydration, the EB experiment was dismantled in autumn 2012. Samples obtained from the granular bentonite material (GBM), and bentonite blocks were sent to a laboratory for further analysis. The bentonite samples analyzed at the Laboratory of Mechanic of Lille (LML) were obtained from the CMT1, CMT2, CMT3 and RW sections. Their physical states were determined, as were their effective gas permeability and swelling capacity at different relative humidity (RH) levels. The results indicate that the water contents of the GBM determined in the laboratory ranged between 25.63% and 44.88% and that the dry densities ranged between 1.13 and 1.44 g/cm{sup 3}. The blocks had water contents similar to (or slightly higher than) those of the GBM, and their dry densities had decreased from an initial value of 1.69 g/cm{sup 3} to values close to 1.30 g/cm{sup 3}, which were similar to the average values found in the GBM. The effective gas permeabilities of the GBM samples were within the range of 1.50 × 10{sup −22} m{sup 2} and 1.03 × 10{sup −17} m{sup 2}, whereas, the corresponding values of the samples obtained from the blocks were between 2.20 × 10{sup −21} m{sup 2} and 5.12 × 10{sup −21} m{sup 2}. The permeability values are primarily related to the dry densities and water contents of the samples. Contact with

  4. THE INTERPLANETARY NETWORK SUPPLEMENT TO THE FERMI GBM CATALOG OF COSMIC GAMMA-RAY BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Hurley, K. [University of California, Berkeley, Space Sciences Laboratory, 7 Gauss Way, Berkeley, CA 94720-7450 (United States); Pal' shin, V. D.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Mazets, E. P.; Svinkin, D. S. [Ioffe Physical Technical Institute, St. Petersburg 194021 (Russian Federation); Briggs, M. S.; Connaughton, V. [University of Alabama in Huntsville, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, C. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Goldsten, J. [Applied Physics Laboratory, Johns Hopkins University, Laurel, MD 20723 (United States); Boynton, W.; Fellows, C.; Harshman, K. [University of Arizona, Department of Planetary Sciences, Tucson, AZ 85721 (United States); Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B. [Space Research Institute, 84/32, Profsoyuznaya, Moscow 117997 (Russian Federation); Rau, A., E-mail: khurley@ssl.berkeley.edu [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse, Postfach 1312, D-85748 Garching (Germany); and others

    2013-08-15

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 427 were observed by at least one other instrument in the nine-spacecraft IPN. Of the 427, the localizations of 149 could be improved by arrival time analysis (or {sup t}riangulation{sup )}. For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.'4 and 32 Degree-Sign , depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1{sigma} GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 Degree-Sign systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If we then multiply the resulting error radii by a factor of three, the two samples agree in slightly over 98% of the cases, providing a good estimate of the GBM 3{sigma} error radius. The IPN 3{sigma} error boxes have areas between about 1 arcmin{sup 2} and 110 deg{sup 2}, and are, on the average, a factor of 180 smaller than the corresponding GBM localizations. We identify two bursts in the IPN/GBM sample that did not appear in the GBM catalog. In one case, the GBM triggered on a terrestrial gamma flash, and in the other, its origin was given as ''uncertain''. We also discuss the sensitivity and calibration of the IPN.

  5. On the GBM event seen 0.4 sec after GW 150914

    CERN Document Server

    Greiner, J; Savchenko, V; Yu, H -F

    2016-01-01

    In view of the recent report by Connaughton [arXiv:1602.03920.v3] we analyse continuous TTE data of Fermi-GBM around the time of the gravitational wave event GW 150914. We find that after proper accounting for low count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broad-band light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  6. Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics.

    Science.gov (United States)

    St-Coeur, Patrick-Denis; Poitras, Julie J; Cuperlovic-Culf, Miroslava; Touaibia, Mohamed; Morin, Pier

    2015-10-01

    Glioblastoma multiforme (GBM) is the most common form of malignant glioma. Current therapeutic approach to treat this malignancy involves a combination of surgery, radiotherapy and chemotherapy with temozolomide. Numerous mechanisms contributing to inherent and acquired resistance to this chemotherapeutic agent have been identified and can lead to treatment failure. This study undertook a metabolomics-based approach to characterize the metabolic profiles observed in temozolomide-sensitive and temozolomide-resistant GBM cell lines as well as in a small sub-set of primary GBM tumors. This approach was also utilized to explore the metabolic changes modulated upon cell treatment with temozolomide and lomeguatrib, an MGMT inhibitor with temozolomide-sensitizing potential. Metabolites previously explored for their potential role in chemoresistance including glucose, citrate and isocitrate demonstrated elevated levels in temozolomide-resistant GBM cells. In addition, a signature of metabolites comprising alanine, choline, creatine and phosphorylcholine was identified as up-regulated in sensitive GBM cell line across different treatments. These results present the metabolic profiles associated with temozolomide response in selected GBM models and propose interesting leads that could be leveraged for the development of therapeutic or diagnostic tools to impact temozolomide response in GBMs.

  7. Time Domain Astronomy with Fermi GBM in the Multi-messenger Era

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2017-08-01

    As the Multi-Messenger era begins with detections of gravitational waves with LIGO and neutrinos with IceCube, the Fermi Gamma-ray Burst Monitor provides context observations of gamma-ray transients between 8 keV and 40 MeV. Fermi GBM has a wide field of view, high uptime, and both in-orbit triggering and high time resolution continuous data enabling offline searches for weaker transients. GBM detects numerous gamma-ray bursts (GRBs), soft gamma-ray repeaters, X-ray bursters, solar flares and terrestrial gamma-ray flashes. Longer timescale transients, predominantly in our galaxy so far, are detected using the Earth occultation technique and epoch-folding for periodic sources. The GBM team has developed two ground-based searches to enhance detections of faint transients, especially short GRBs. The targeted search uses the time and location of an event detected with another instrument to coherently search the GBM data, increasing the sensitivity to a transient. The untargeted search agnostically searches the GBM data for all directions and times to find weaker transients. This search finds about 80 short GRBs per year, in addition to the 40 per year triggered on-orbit. With its large field of view, high duty cycle and increasingly sophisticated detection methods, Fermi GBM is expected to have a major role in the Multi-Messenger era.

  8. On the Fermi-GBM Event 0.4 s after GW150914

    Science.gov (United States)

    Greiner, J.; Burgess, J. M.; Savchenko, V.; Yu, H.-F.

    2016-08-01

    In view of the recent report by Connaughton et al., we analyze continuous time-tagged event (TTE) data of Fermi-gamma-ray burst monitor (GBM) around the time of the gravitational-wave event GW 150914. We find that after proper accounting for low-count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broadband light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  9. Is the GW150914-GBM really associated with the GW150914?

    CERN Document Server

    Xiong, Shaolin

    2016-01-01

    Finding the electromagnetic (EM) counterpart is critically important for a gravitational wave event. Although many efforts have been made to search for the purported EM counterpart of GW150914, the first gravitational wave event detected by LIGO, only Fermi/GBM reported an excess above background (i.e. GW150914-GBM) at 0.4 s after the LIGO trigger time, that is possibly associated with this GW event (Connaughton et al. 2016). However, since there is no significant detection by the INTEGRAL/SPI-ACS around the time of GW150914-GBM, a great debate has been raised about whether GW150914-GBM is of astrophysical origin and associated with the GW150914 (Savchenko et al. 2016). In order to answer this question, we re-analyzed the GBM data with a straightforward but sophisticated method. We find that the excess of GW150914-GBM mostly comes from those detectors with bad viewing angles to the GW event, whereas the good viewing detectors see nothing significant beyond background fluctuation around the trigger time of GW1...

  10. Paradox of Migration in Kolkata: A Megacity in GBM Delta

    Science.gov (United States)

    Das, S.; Hazra, S.; Ghosh, T.

    2015-12-01

    Contrary to other coastal cities (Mumbai, Chennai, Bhubaneswar etc.) in India, Kolkata, the largest city of India until 1990, has been showing a persistent trend of out-migration over the last decade. The situation is more paradoxical when compared to Dhaka in Bangladesh, the other coastal city in Ganga-Brahmaputra-Meghna (GBM) delta. Exacerbating impacts of Climate Change like accelerated sea level rise, impact of cyclones, rising temperature and high rainfall events and waterlogging, vis-à-vis the density of poor population in slums, Kolkata has been assessed as one of the most vulnerable cities of the world. However, Kolkata has long been a preferred destination for migrants for its port based economy, existence of industrial belt with labour intensive industries. The city and its surrounding districts attracted a massive influx of trans-border migrants when India and Bangladesh gained Independence in 1947 and 1971 respectively. The paper attempts to explore reasons behind the present trend of depopulation in the erstwhile preferred migration destination. This paper distinguishes between 'Kolkata City' (census district) with 4.5 million residents and 'Kolkata Megacity' which encompasses also the peri-urban areas and home to almost 14.1 million people according to Census 2011. Analysing migration as an ongoing research activity under DECCMA project, an overall 'in-migration' pattern can be deciphered in Kolkata 'megacity'. On the contrary, the Kolkata 'city' located right in the heart of the megacity exhibits negative net migration (-5.11%) i.e. high 'out-migration'. Plausible causes can be movement of people from Kolkata 'city' to peri-urban areas and satellite towns (urban to urban migration) probably due to closure of labour intensive industries, comparatively lower land prices, availability of space and accommodation, lower costs of living, development of different modes of commutation and communication. Further growth of population in the Kolkata Megacity

  11. Implication of the association between GBM transient 150914 and LIGO Gravitational Wave event GW150914

    CERN Document Server

    Li, Xiang; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-01-01

    On September 14, 2015 the two detectors of LIGO simultaneously detected a transient gravitational-wave signal GW150914 and the Fermi GBM observations found a weak short gamma-ray burst (SGRB)-like transient (i.e., the GBM transient 150914). The time and location coincidences favor the association between GW150904 and GBM transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event is indeed a distinct outlier in the $E_{\\rm p,rest}-E_{\\rm iso}$ and $E_{\\rm p,rest}-L_{\\gamma}$ diagrams ($E_{\\rm iso}$ is the isotropic-equivalent energy, $L_\\gamma$ is the luminosity and $E_{\\rm p,rest}$ is the rest frame peak energy of the prompt emission), possibly due to its specific binary-black-hole merger origin. However, the presence of a "new" group of SGRBs with "low" $L_\\gamma$ and $E_{\\rm iso}$ but high $E_{\\rm p,rest}$ is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, we estimate the accretion disk mass to be $\\sim 10...

  12. An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy

    Directory of Open Access Journals (Sweden)

    Vinay Minocha

    2014-01-01

    Full Text Available Introduction. The most commonly seen glomerular disease in HIV infected patients is HIV-associated nephropathy (HIVAN; however, a multitude of other nephropathies can occur in HIV infection with an almost equal cumulative frequency. We report an unusual case of a patient with clinical and histological evidence of HIVAN in which the diagnosis was initially confounded by the finding of an elevated serum anti-glomerular basement membrane (anti-GBM antibody. Case Presentation. We present a case of a 27-year-old African American female with a history of schizophrenia, cocaine abuse, and HIV infection who upon admission to our hospital was found to have severe acute kidney injury requiring hemodialysis. Urine studies revealed nephrotic range proteinuria and a serological workup was positive for anti-GBM antibody elevation with a value of 91 units (normal: 0–20 units. A renal biopsy revealed HIVAN with no evidence of crescentic glomerulonephritis or anti-GBM disease. Conclusion. This case highlights the need for careful interpretation of anti-GBM antibody tests in HIV infected patients with kidney disease and, in particular, the need for biopsy confirmation of the diagnosis prior to starting therapy. More research is needed to study the prognostic correlation between the degree of anti-GBM antibody elevation in HIVAN and disease severity.

  13. The First Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Briggs, Michael; Connaughton, Valerie; Stanbro, Matthew; Zhang, Binbin; Bhat, Narayana; Fishman, Gerald; Roberts, Oliver; Fitzpatrick, Gerard; McBreen, Shelia; Grove, Eric; Chekhtman, Alexandre

    2015-04-01

    We present summary results from the first catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Space Telescope. The catalog reports parameters for over 2700 TGFs. Since the launch of Fermi in 2008 the TGF detection sensitivity of GBM has been improved several times, both in the flight software and in ground analysis. Starting in 2010 July individual photons were downloaded for portions of the orbits, enabling an off-line search that found weaker and shorter TGFs. Since 2012 November 26 this telemetry mode has been extended to continuous coverage. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs).

  14. Earth Occultation Monitoring of the Hard X-ray/Low-Energy Gamma Ray Sky with GBM

    Science.gov (United States)

    Cherry, Michael L.; Camero-Arranz, A.; Case, G. L.; Chaplin, V.; Finger, M. H.; Jenke, P. A.; Rodi, J. C.; Wilson-Hodge, C. A.; GBM Earth Occultation Team

    2012-01-01

    By utilizing the Earth occultation technique (EOT), the Gamma-Ray Burst Monitor (GBM) instrument aboard Fermi has been used to make nearly continuous full-sky observations in the 8-1000 keV energy range. The GBM EOT analysis program currently monitors an input catalog containing 235 sources. We will present the GBM catalog of sources observed in the first 3 years of the EOT monitoring program, with special emphasis on the high energy (>100 keV) and time-variable sources, in particular the Crab, Cyg X-1, and A0535+26. We will also describe the initial results of an all-sky imaging analysis of the EOT data, with comparisons to the Swift, INTEGRAL, and Fermi LAT catalogs. This work is supported by the NASA Fermi Guest Investigator program, NASA/Louisiana Board of Regents, and Spanish Ministerio de Ciencia de Innovacion.

  15. The Fermi GBM and LAT follow-up of GW150914

    Directory of Open Access Journals (Sweden)

    Bissaldi E.

    2017-01-01

    Here we present observations by the Fermi Gamma-Ray BurstMonitor (GBM [1] and by the Large Area Telescope (LAT [2] of the LIGO Gravitational Wave event GW150914, which has been associated to the merger of two stellar-mass BHs. We report the presence of a weak transient event in GBM data, close in time to the LIGO one. We discuss the characteristics of this GBM transient, which are consistent with a weak short GRB arriving at a large angle to the direction in which Fermi was pointing. Furthermore, we report LAT upper limits (ULs for GW150914, and we present the strategy for follow-up observations of GW events with the LAT.

  16. Fermi GBM detects pulsations from Swift J0243.6+6124

    Science.gov (United States)

    Jenke, P.; Wilson-Hodge, C. A.

    2017-10-01

    On October 1, 2017, blind searches of Fermi GBM data detected strong pulsations from an unknown source with a pulse period of 4.927 seconds. Upon the Swift discovery of the new 9.86 second accreting NS, Swift J0243.6+6124 (ATeL #10809), the GBM pulsar project performed a dedicated search for pulsations around the pulse period of 9.86 seconds from the direction of Swift J0243.6+6124 starting September 01 through October 2, 2017.

  17. Rituximab for the treatment of refractory simultaneous anti-glomerular basement membrane (anti-GBM) and membranous nephropathy.

    Science.gov (United States)

    Bandak, Ghassan; Jones, Bruce A; Li, Jian; Yee, Jerry; Umanath, Kausik

    2014-02-01

    Antibody-mediated anti-glomerular basement membrane (anti-GBM) disease occurs rarely in the presence of another B-cell disorder, membranous nephropathy. The coexistence of these two autoimmune disorders would be anticipated to require differing, specific therapies targeted to each disease process. We describe a case of concomitant membranous nephropathy and anti-GBM disease in which conventional therapy, including steroids, plasmapheresis and cyclophosphamide, failed to attenuate the anti-GBM disease, yet responded to an alternative treatment of rituximab. This B-cell directed, monoclonal, chimeric antibody treatment substantially reduced anti-GBM antibody titers and led to discontinuation of plasmapheresis, while maintaining the remission of membranous nephropathy and anti-GBM disease.

  18. Correlative Spectral Analysis of Gamma-Ray Bursts using Swift-BAT and GLAST-GBM

    CERN Document Server

    Stamatikos, Michael; Band, David L

    2008-01-01

    We discuss the preliminary results of spectral analysis simulations involving anticipated correlated multi-wavelength observations of gamma-ray bursts (GRBs) using Swift's Burst Alert Telescope (BAT) and the Gamma-Ray Large Area Space Telescope's (GLAST) Burst Monitor (GLAST-GBM), resulting in joint spectral fits, including characteristic photon energy (Epeak) values, for a conservative annual estimate of ~30 GRBs. The addition of BAT's spectral response will (i) complement in-orbit calibration efforts of GBM's detector response matrices, (ii) augment GLAST's low energy sensitivity by increasing the ~20-100 keV effective area, (iii) facilitate ground-based follow-up efforts of GLAST GRBs by increasing GBM's source localization precision, and (iv) help identify a subset of non-triggered GRBs discovered via off-line GBM data analysis. Such multi-wavelength correlative analyses, which have been demonstrated by successful joint-spectral fits of Swift-BAT GRBs with other higher energy detectors such as Konus-WIND ...

  19. Performance of two strategies for urgent ANCA and anti-GBM analysis in vasculitis

    NARCIS (Netherlands)

    de Joode, Anoek A. E.; Roozendaal, Caroline; van der Leij, Marcel J.; Bungener, Laura B.; Sanders, Jan Stephan; Stegeman, Coen A.

    2014-01-01

    Background: In anti-neutrophil cytoplasmic antibodies (ANCA) associated small vessel vasculitis (AAV), rapid testing for ANCA and anti-glomerular basement membrane (GBM) antibodies may be beneficial for therapeutic purpose. Objective: We analysed the diagnostic performance of two rapid ANCA and anti

  20. Implications of the Tentative Association between GW150914 and a Fermi-GBM Transient

    Science.gov (United States)

    Li, Xiang; Zhang, Fu-Wen; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-08-01

    The merger-driven gamma-ray bursts (GRBs) and their associated gravitational-wave (GW) radiation, if both are successfully detected, have some far-reaching implications, including, for instance: (i) the statistical comparison of the physical properties of the short/long-short GRBs with and without GW detection can test the general origin model; (ii) revealing the physical processes taking place at the central engine; (iii) measuring the velocity of the gravitational wave directly/accurately. In this work, we discuss these implications in the case of a possible association of GW150914/Gamma-ray Burst Monitor (GBM) transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event may be a distinct outlier in some statistical diagrams, possibly due to its specific binary black hole merger origin. However, the presence of a “new” group of SGRBs with “unusual” physical parameters is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, the magnetic activity rather than the neutrino process is likely responsible for the energy extraction, and the accretion disk mass is estimated to be ˜10-5 M ⊙. The GW150914/GBM transient 150914 association, if confirmed, would provide the first opportunity to directly measure the GW velocity, and its departure from the speed of the light should be within a factor of ˜10-17.

  1. Earth Occultation Imaging of the Low Energy Gamma-Ray Sky with GBM

    CERN Document Server

    Rodi, J; Case, G L; Camero-Arranz, A; Chaplin, C; Finger, M H; Jenke, P; Wilson-Hodge, C A

    2013-01-01

    The Earth Occultation Technique (EOT) has been applied to Fermi's Gamma-ray Burst Monitor (GBM) to perform all-sky monitoring for a predetermined catalog of hard X-ray/soft gamma-ray sources. Imaging with a Differential filter using the Earth Occultation Method (IDEOM) has been developed to search for sources not in the catalog, thus completing the catalog and reducing a source of systematic error in EOT. IDEOM is a tomographic imaging method that takes advantage of the orbital precession of the Fermi satellite. Using IDEOM, all-sky images have been generated for ~4 years of GBM data in the 12-50 keV, 50-100 keV and 100-300 keV energy bands in search of sources otherwise unmodeled by the GBM occultation analysis. Analysis resulted in the detection of 43 sources in the 12-50 keV energy band, 23 sources in the 50-100 keV energy band, and 7 sources in the 100-300 keV energy band. IDEOM analysis has resulted in the addition of 16 sources to the GBM-EOT catalog. We also present the first joined averaged spectra fo...

  2. MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

    Science.gov (United States)

    Grossman, Rachel; Burger, Peter; Soudry, Ethan; Tyler, Betty; Chaichana, Kaisorn L; Weingart, Jon; Olivi, Alessandro; Gallia, Gary L; Sidransky, David; Quiñones-Hinojosa, Alfredo; Ye, Xiaobu; Brem, Henry

    2015-12-01

    We examined the relationship between the O(6)-methylguanine-methyltransferase (MGMT) methylation status and clinical outcomes in newly diagnosed glioblastoma multiforme (GBM) patients who were treated with Gliadel wafers (Eisai, Tokyo, Japan). MGMT promoter methylation has been associated with increased survival among patients with GBM who are treated with various alkylating agents. MGMT promoter methylation, in DNA from 122 of 160 newly diagnosed GBM patients treated with Gliadel, was determined by a quantitative methylation-specific polymerase chain reaction, and was correlated with overall survival (OS) and recurrence-free survival (RFS). The MGMT promoter was methylated in 40 (32.7%) of 122 patients. The median OS was 13.5 months (95% confidence interval [CI] 11.0-14.5) and RFS was 9.4 months (95% CI 7.8-10.2). After adjusting for age, Karnofsky performance score, extent of resection, temozolomide (TMZ) and radiation therapy (RT), the newly diagnosed GBM patients with MGMT methylation had a 15% reduced mortality risk, compared to patients with unmethylated MGMT (hazard ratio 0.85; 95% CI 0.56-1.31; p=0.46). The patients aged over 70 years with MGMT methylation had a significantly longer median OS of 13.5 months, compared to 7.6 months in patients with unmethylated MGMT (p=0.027). A significant difference was also found in older patients, with a median RFS of 13.1 versus 7.6 months for methylated and unmethylated MGMT groups, respectively (p=0.01). Methylation of the MGMT promoter in newly diagnosed GBM patients treated with Gliadel, RT and TMZ, was associated with significantly improved OS compared to the unmethylated population. In elderly patients, methylation of the MGMT promoter was associated with significantly better OS and RFS.

  3. Rituximab in anti-GBM disease: A retrospective study of 8 patients.

    Science.gov (United States)

    Touzot, Maxime; Poisson, Johanne; Faguer, Stanislas; Ribes, David; Cohen, Pascal; Geffray, Loic; Anguel, Nadia; François, Helene; Karras, Alexandre; Cacoub, Patrice; Durrbach, Antoine; Saadoun, David

    2015-06-01

    Anti-glomerular basement membrane (GBM) disease is a rare autoantibody-mediated disorder presenting as rapidly progressive glomerulonephritis, and often with pulmonary hemorrhage. Antibody removal with plasmapheresis and immunosuppressive drugs are the cornerstones of the treatment. Data regarding the use of specific B-cell depleting therapy such as rituximab are lacking. We conducted a retrospective observational study of 8 patients with severe and/or refractory GBM disease that received rituximab therapy. Eight patients (2 men, 6 women) with a mean age of 26 ± 13.1 years old were included. Seven had severe renal involvement [median creatinin level was 282 μmol/l, range (65-423)] requiring high immunosuppressive or plasmapheresis dependent, and two had relapse of pulmonary hemorrhage including one with renal failure. Patients received an initial immunosuppressive treatment including steroid and cyclosphosphamide (n = 8) and plasmapheresis (n = 5). Except one late relapse, rituximab therapy was started within two months after diagnosis. All patients except one received 4 weekly dose of rituximab (375 mg(2)). Anti-GBM antibodies were still present in 6/8 patients, at rituximab initiation. Complete remission was observed in 7 out of 8 patients, mostly 3 months after rituximab therapy. After a mean follow-up of 25.6 months (range 4-93), patient and renal survival were 100% and 75% respectively, but rituximab use did not improve GFR. Anti-GBM antibodies remained negative for all patients during follow-up. Only one patient developed a severe bacterial infection but no opportunistic or viral infections were reported. Rituximab may represent an additional and/or alternative therapy in the induction treatment of anti-GBM disease. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. CABOZANTINIB IS EFFECTIVE IN A SUBSET OF XENOGRAFT GBM TUMORS AND AFFECTS MULTIPLE SIGNALING PATHWAYS

    Science.gov (United States)

    Mikkelsen, Tom; deCarvalho, Ana C.; Arnold, Kimberly; Mueller, Claudius; Petricoin, Emanuel F; Poisson, Laila M.; Irtenkauf, Susan; Hasselbach, Laura

    2014-01-01

    BACKGROUND: (blind field). METHODS: Neurospheres enriched in CSCs were cultured from resected GBM tumors. Sensitivity to cabozantinib was determined in vitro. Cells were treated (IC40) in triplicate, and cell lysates were analyzed by reverse phase protein microarrays (RPPAs). GBM CSCs were implanted intracranially into nude mice. Cabozantinib was administered by oral gavage at a dose of 60 mg/kg for 4 weeks (5 days/week) as a single agent or in combination with 40 mg/kg TMZ. Tumor growth and response to treatment were monitored by non-invasive in vivo bioluminescence imaging (BLI) using the Xenogen IVIS System (Caliper Life Sciences), and overall survival. RESULTS: Sensitivity to cabozantinib treatment varied for the different GBM CSCs. From 70 proteins and phosphoproteins measured, 29 distributed among several signaling pathways were significantly altered after treatment in both resistant and sensitive GBM CSCs, including Met, Ret, AKT, MAPK/ERK. Cabozantinib single agent treatment reduced GBM tumor growth and increased mouse survival in two xenograft lines. Cabozantinib monotherapy reduced tumor size, as measured by BLI, but had no significant effect on overall survival for another xenograft line, however, the combination treatment resulted in sensitization of these xenografts to TMZ treatment. RPPA confirmed downregulation of the described targets for XL184, including activated Met, VEGFR2 and Ret (in vitro). CONCLUSIONS: Consistent with the clinical experience, both sensitive and resistant GBMs are represented in our CSC xenografts. More extensive evaluation will likely identify baseline biomarkers which might be valuable in identifying potentially sensitive sub-populations for subsequent clinical trials. RPPA and next-gen sequencing (NGS) on terminal tumors is underway. SECONDARY CATEGORY: Tumor Biology.

  5. Fermi GBM Observations of LIGO Gravitational-wave Event GW150914

    Science.gov (United States)

    Connaughton, V.; Burns, E.; Goldstein, A.; Blackburn, L.; Briggs, M. S.; Zhang, B.-B.; Camp, J.; Christensen, N.; Hui, C. M.; Jenke, P.; Littenberg, T.; McEnery, J. E.; Racusin, J.; Shawhan, P.; Singer, L.; Veitch, J.; Wilson-Hodge, C. A.; Bhat, P. N.; Bissaldi, E.; Cleveland, W.; Fitzpatrick, G.; Giles, M. M.; Gibby, M. H.; von Kienlin, A.; Kippen, R. M.; McBreen, S.; Mailyan, B.; Meegan, C. A.; Paciesas, W. S.; Preece, R. D.; Roberts, O. J.; Sparke, L.; Stanbro, M.; Toelge, K.; Veres, P.

    2016-07-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational-wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO) event GW150914 reveal the presence of a weak transient above 50 keV, 0.4 s after the GW event, with a false-alarm probability of 0.0022 (2.9σ). This weak transient lasting 1 s was not detected by any other instrument and does not appear to be connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event are consistent with a weak short gamma-ray burst (GRB) arriving at a large angle to the direction in which Fermi was pointing where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, then this electromagnetic signal from a stellar mass black hole binary merger is unexpected. We calculate a luminosity in hard X-ray emission between 1 keV and 10 MeV of {1.8}-1.0+1.5× {10}49 erg s-1. Future joint observations of GW events by LIGO/Virgo and Fermi GBM could reveal whether the weak transient reported here is a plausible counterpart to GW150914 or a chance coincidence, and will further probe the connection between compact binary mergers and short GRBs.

  6. microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.

    Science.gov (United States)

    Tezcan, Gulcin; Tunca, Berrin; Bekar, Ahmet; Preusser, Matthias; Berghoff, Anna Sophie; Egeli, Unal; Cecener, Gulsah; Ricken, Gerda; Budak, Ferah; Taskapılıoglu, Mevlut Ozgur; Kocaeli, Hasan; Tolunay, Sahsine

    2014-07-01

    Temozolomide (TMZ) is widely used to treat glioblastoma multiforme (GBM). Although the MGMT gene methylation status is postulated to correlate with TMZ response, some patients with a methylated MGMT gene still do not benefit from TMZ therapy. Cancer stem cells (CSCs) may be one of the causes of therapeutic resistance, but the molecular mechanism underlying this resistance is unclear. microRNA (miRNA) deregulation has been recognized as another chemoresistance modulating mechanism. Thus, we aimed to evaluate the miRNA expression patterns associated with chemoresistance that is dependent on the CSC status in GBM tumors to identify therapeutic biomarkers. CSCs were identified in 5 of 20 patients' tumor tissues using magnetic separation. CSC (+) tumors displayed a significant induction of CpG island methylation in the MGMT gene promoter (p = 0.009). Using real-time reverse transcription polymerase chain reaction (qRT-PCR), 9 miRNAs related to GBM (mir-181b, miR-153, miR-137, miR-145, miR-10a, miR-10b, let-7d, miR-9, and miR-455-3p), which are associated with cell cycle and invasion was analyzed in tumor samples. Low miR-181b and high miR-455-3p expression levels were detected (p = 0.053, p = 0.004; respectively) in CSC (+) tumors. Analysis revealed a significant correlation between miR-455-3p expression and Smad2 protein levels as analyzed by immunohistochemistry in CSC (+) tumors (p = 0.002). Thus, miR-455-3p may be involved in TMZ resistance in MGMT methylated CSC (+) GBM patients. Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for GBM treatment and new directions for the development of anticancer drugs.

  7. TU-AB-BRA-11: Evaluation of Fully Automatic Volumetric GBM Segmentation in the TCGA-GBM Dataset: Prognosis and Correlation with VASARI Features

    Energy Technology Data Exchange (ETDEWEB)

    Rios Velazquez, E [Dana-Farber Cancer Institute | Harvard Medical School, Boston, MA (United States); Meier, R [Institute for Surgical Technology and Biomechanics, Bern, NA (Switzerland); Dunn, W; Gutman, D [Emory University School of Medicine, Atlanta, GA (United States); Alexander, B [Dana- Farber Cancer Institute, Brigham and Womens Hospital, Harvard Medic, Boston, MA (United States); Wiest, R; Reyes, M [Institute for Surgical Technology and Biomechanics, University of Bern, Bern, NA (Switzerland); Bauer, S [Institute for Surgical Technology and Biomechanics, Support Center for Adva, Bern, NA (Switzerland); Aerts, H [Dana-Farber/Brigham Womens Cancer Center, Boston, MA (United States)

    2015-06-15

    Purpose: Reproducible definition and quantification of imaging biomarkers is essential. We evaluated a fully automatic MR-based segmentation method by comparing it to manually defined sub-volumes by experienced radiologists in the TCGA-GBM dataset, in terms of sub-volume prognosis and association with VASARI features. Methods: MRI sets of 67 GBM patients were downloaded from the Cancer Imaging archive. GBM sub-compartments were defined manually and automatically using the Brain Tumor Image Analysis (BraTumIA), including necrosis, edema, contrast enhancing and non-enhancing tumor. Spearman’s correlation was used to evaluate the agreement with VASARI features. Prognostic significance was assessed using the C-index. Results: Auto-segmented sub-volumes showed high agreement with manually delineated volumes (range (r): 0.65 – 0.91). Also showed higher correlation with VASARI features (auto r = 0.35, 0.60 and 0.59; manual r = 0.29, 0.50, 0.43, for contrast-enhancing, necrosis and edema, respectively). The contrast-enhancing volume and post-contrast abnormal volume showed the highest C-index (0.73 and 0.72), comparable to manually defined volumes (p = 0.22 and p = 0.07, respectively). The non-enhancing region defined by BraTumIA showed a significantly higher prognostic value (CI = 0.71) than the edema (CI = 0.60), both of which could not be distinguished by manual delineation. Conclusion: BraTumIA tumor sub-compartments showed higher correlation with VASARI data, and equivalent performance in terms of prognosis compared to manual sub-volumes. This method can enable more reproducible definition and quantification of imaging based biomarkers and has a large potential in high-throughput medical imaging research.

  8. SU-C-BRE-03: Dual Compartment Mathematical Modeling of Glioblastoma Multiforme (GBM)

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Kupelian, P; Kaprealian, T; Selch, M; Low, D; Pajonk, F; Sheng, K [UCLA, Los Angeles, CA (United States)

    2014-06-15

    Purpose: To explore the aggressive recurrence and radioresistence of GBM with a dual compartment tumor survival mathematical model based on intrinsic tumor heterogeneity, cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The repopulation and differentiation responses to radiotherapy of a solid tumor were simulated using an Ordinary Differential Equation (ODE). To obtain the tumor radiobiological parameters, we assumed that a tumor consists of two subpopulations, each with its distinctive linear quadratic parameters. The dual compartment cell survival model was constructed as SF(D)=F × exp(-α{sub 1} D-β{sub 1}D{sup 2}) + (1-F) × exp(-α{sub 2}D-β{sub 2}D{sup 2}) for a single fraction of treatment, with F as the fraction of CSC, and α and β describing the radiological properties of each population. Robust least square fitting was performed on clonogenic survival data from one GBM (U373MG) and one NSCLC (H460) cell line. The fit parameters were then used in the ODE model to predict treatment outcome of various treatment schemes. Results: The fit parameters from GBM cell survival data were (F, α{sub 1}, β{sub 1}, α{sub 2}, β{sub 2})=(0.0396, 0.0801, 0.0006, 0.1363, 0.0279), exhibiting two populations with distinctive radiological properties, CSC more radioresistant than DCC. The GBM cell line exhibited significantly poorer tumor control than its single compartment model prediction and NSCLC, which responded well to hypofrationation. The increased radioresistance was due to rapid regrowth of the DCC compartment triggered by its depletion while maintaining a viable CSC population. The rapid regrowth can be reduced by treating dose fractions ≤ 2 Gy with a prolonged treatment period. Conclusion: The interaction between a radioresistant CSC compartment and DCC compartment can explain the poor clinical outcome of GBM after radiotherapy despite dose escalation and hypofractionation attempts. Lower dose fractions result in better treatment

  9. Searching for Unmodeled Sources Using the Earth Occultation Data from the Fermi GBM

    CERN Document Server

    Rodi, James; Cherry, Michael L; Camero-Arranz, Ascension; Finger, Mark H; Jenke, Peter; Wilson-Hodge, Colleen A; Chaplin, Vandiver

    2011-01-01

    Employing the 12 NaI detectors in the Fermi GBM, the Earth Occultation Technique (EOT) can be used to measure the fluxes of x-ray and gamma-ray sources. Each time a source passes behind the Earth (or emerges from behind the Earth), a step-like feature is produced in the detector count rate. With a predefined catalog of source positions, the times of the occultation steps can be calculated, the individual steps fit, and the fluxes derived. However, in order to find new sources and generate a complete catalog, a method is needed for generating an image of the sky. An imaging algorithm has been developed to generate all-sky images using the GBM data. Here we present imaging results from ~2.5 years of data in the 12-25 keV and 100-300 keV energy bands.

  10. THE FERMI GBM GAMMA-RAY BURST SPECTRAL CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, Adam; Burgess, J. Michael; Preece, Robert D.; Briggs, Michael S.; Guiriec, Sylvain; Connaughton, Valerie; Paciesas, William S.; Bhat, P. N.; Chaplin, Vandiver [Physics Department, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Van der Horst, Alexander J.; Meegan, Charles A. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Wilson-Hodge, Colleen A.; Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Von Kienlin, Andreas; Bissaldi, Elisabetta; Diehl, Roland; Foley, Suzanne [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, 1500 Perimeter Parkway, Huntsville, AL 35806 (United States); and others

    2012-03-01

    We present systematic spectral analyses of gamma-ray bursts (GRBs) detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first two years of operation. This catalog contains two types of spectra extracted from 487 GRBs, and by fitting four different spectral models, this results in a compendium of over 3800 spectra. The models were selected based on their empirical importance to the spectral shape of many GRBs, and the analysis performed was devised to be as thorough and objective as possible. We describe in detail our procedure and criteria for the analyses, and present the bulk results in the form of parameter distributions. This catalog should be considered an official product from the Fermi GBM Science Team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  11. The Interplanetary Network Supplement to the Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    CERN Document Server

    Hurley, K; Aptekar, R L; Golenetskii, S V; Frederiks, D D; Mazets, E P; Svinkin, D S; Briggs, M S; Connaughton, V; Meegan, C; Goldsten, J; Boynton, W; Fellows, C; Harshman, K; Mitrofanov, I G; Golovin, D V; Kozyrev, A S; Litvak, M L; Sanin, A B; Rau, A; von Kienlin, A; Zhang, X; Yamaoka, K; Fukazawa, Y; Hanabata, Y; Ohno, M; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Barthelmy, S; Cline, T; Gehrels, N; Cummings, J; Krimm, H A; Smith, D M; Del Monte, E; Feroci, M; Marisaldi, M

    2013-01-01

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 393 were observed by at least one other instrument in the 9-spacecraft IPN. Of the 393, the localizations of 146 could be improved by arrival time analysis (or "triangulation"). For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.4 arcminutes and 32 degrees, depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1 sigma GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 degree systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If ...

  12. The Cross-Calibration of Swift-BAT and Fermi-GBM via Correlative Spectral Analysis of GRBs

    CERN Document Server

    Stamatikos, Michael

    2009-01-01

    We report on recent inter-calibration studies featuring Swift's Burst Alert Telescope (BAT) and Fermi's Gamma-ray Burst Monitor (GBM) based upon correlated observations of GRBs 080804 and 080810, via their resultant joint spectral analysis. Swift's intrinsic multi-wavelength instrumentation and dynamical response complement Fermi's superior energy range. The addition of BAT's spectral response will (i) facilitate in-orbit GBM detector response calibration, (ii) augment Fermi's low energy sensitivity, (iii) enable ground-based follow-up efforts of Fermi GRBs, and (iv) help identify a subset of GRBs discovered via off-line GBM data analysis, for an annual estimate of ~30 GRBs. The synergy of BAT and GBM augments previous successful joint spectral fit efforts by enabling the study of peak photon energies (Epeak), while leveraging the over eleven energy decades afforded by Fermi's Large Area Telescope (LAT), in conjunction with Swift's X-Ray (XRT) and Ultraviolet-Optical (UVOT) Telescopes, for an unprecedented pr...

  13. Size of shell universe in light of Fermi GBM transient associated with GW150914

    Directory of Open Access Journals (Sweden)

    Merab Gogberashvili

    2016-12-01

    Full Text Available The possible burst occurred in location and temporal consistence with gravitational wave event GW150914, as reported by Fermi GBM, offers a new way of constraining models with extra dimensions. Using the time delay in arrival of the gamma ray transient observed by Fermi Gamma-ray Burst Monitor (GMB relative to the gravitational waves event triggered by the LIGO detectors we investigate the size of the spherical brane-universe expanding in multi-dimensional space–time. It is shown that a joint observation of gravitational waves in association with gamma ray burst can provide a very stringent bound on the spatial curvature of the brain.

  14. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.

    Science.gov (United States)

    Pedchenko, Vadim; Bondar, Olga; Fogo, Agnes B; Vanacore, Roberto; Voziyan, Paul; Kitching, A Richard; Wieslander, Jörgen; Kashtan, Clifford; Borza, Dorin-Bogdan; Neilson, Eric G; Wilson, Curtis B; Hudson, Billy G

    2010-07-22

    In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation in some patients with Alport's syndrome. We compared the conformations of the antibody epitopes in Goodpasture's disease and Alport's post-transplantation nephritis with the intention of finding clues to the pathogenesis of anti-GBM glomerulonephritis. We used an enzyme-linked immunosorbent assay to determine the specificity of circulating autoantibodies and kidney-bound antibodies to NC1 domains. Circulating antibodies were analyzed in 57 patients with Goodpasture's disease, and kidney-bound antibodies were analyzed in 14 patients with Goodpasture's disease and 2 patients with Alport's post-transplantation nephritis. The molecular architecture of key epitope regions was deduced with the use of chimeric molecules and a three-dimensional model of the alpha345NC1 hexamer. In patients with Goodpasture's disease, both autoantibodies to the alpha3NC1 monomer and antibodies to the alpha5NC1 monomer (and fewer to the alpha4NC1 monomer) were bound in the kidneys and lungs, indicating roles for the alpha3NC1 and alpha5NC1 monomers as autoantigens. High antibody titers at diagnosis of anti-GBM disease were associated with ultimate loss of renal function. The antibodies bound to distinct epitopes encompassing region E(A) in the alpha5NC1 monomer and regions E(A) and E(B) in the alpha3NC1 monomer, but they did not bind to the native cross-linked alpha345NC1 hexamer. In contrast, in patients with Alport's post-transplantation nephritis, alloantibodies bound to the E(A) region of the alpha5NC1 subunit in the intact hexamer, and binding decreased on dissociation. The development of Goodpasture

  15. Techniques for Targeted Fermi-GBM Follow-Up of Gravitational-Wave Events

    Science.gov (United States)

    Blackburn, L.; Camp, J.; Briggs, M. S.; Connaughton, V.; Jenke, P.; Christensen, N.; Veitch, J.

    2012-01-01

    The Advanced LIGO and Advanced Virgo ground-based gravitational-wave (GW) detectors are projected to come online 2015 2016, reaching a final sensitivity sufficient to observe dozens of binary neutron star mergers per year by 2018. We present a fully-automated, targeted search strategy for prompt gamma-ray counterparts in offline Fermi-GBM data. The multi-detector method makes use of a detailed model response of the instrument, and benefits from time and sky location information derived from the gravitational-wave signal.

  16. The InterPlanetary Network Supplement to the Second Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    Science.gov (United States)

    Hurley, K.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Svinkin, D. S.; Pal’shin, V. D.; Briggs, M. S.; Meegan, C.; Connaughton, V.; Goldsten, J.; Boynton, W.; Fellows, C.; Harshman, K.; Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B.; Rau, A.; von Kienlin, A.; Zhang, X.; Yamaoka, K.; Fukazawa, Y.; Ohno, M.; Tashiro, M.; Terada, Y.; Barthelmy, S.; Cline, T.; Gehrels, N.; Cummings, J.; Krimm, H. A.; Smith, D. M.; Del Monte, E.; Feroci, M.; Marisaldi, M.

    2017-04-01

    InterPlanetary Network (IPN) data are presented for the gamma-ray bursts in the second Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 462 bursts in that catalog between 2010 July 12 and 2012 July 11, 428, or 93%, were observed by at least 1 other instrument in the 9-spacecraft IPN. Of the 428, the localizations of 165 could be improved by triangulation. For these bursts, triangulation gives one or more annuli whose half-widths vary between about 2.‧3° and 16°, depending on the peak flux, fluence, time history, arrival direction, and the distance between the spacecraft. We compare the IPN localizations with the GBM 1σ, 2σ, and 3σ error contours and find good agreement between them. The IPN 3σ error boxes have areas between about 8 square arcminutes and 380 square degrees, and are an average of 2500 times smaller than the corresponding GBM 3σ localizations. We identify four bursts in the IPN/GBM sample whose origins were given as “uncertain,” but may in fact be cosmic. This leads to an estimate of over 99% completeness for the GBM catalog.

  17. Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.

    Science.gov (United States)

    Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike; Skaftnesmo, Kai Ove; Planagumà, Jesús; Reed, Rolf Kåre; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Rygh, Cecilie Brekke; Chekenya, Martha

    2011-01-01

    Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including glioblastoma multiforme (GBM) and melanoma. Thus, we investigated the mechanism of NG2 mediated malignant progression and its potential as a therapeutic target in clinically relevant GBM and melanoma animal models. Xenografting NG2 overexpressing GBM cell lines resulted in increased growth rate, angiogenesis and vascular permeability compared to control, NG2 negative tumours. The effect of abrogating NG2 function was investigated after intracerebral delivery of lentivirally encoded shRNAs targeting NG2 in patient GBM xenografts as well as in established subcutaneous A375 melanoma tumours. NG2 knockdown reduced melanoma proliferation and increased apoptosis and necrosis. Targeting NG2 in two heterogeneous GBM xenografts significantly reduced tumour growth and oedema levels, angiogenesis and normalised vascular function. Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy.

  18. Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.

    Directory of Open Access Journals (Sweden)

    Jian Wang

    Full Text Available Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4 or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including glioblastoma multiforme (GBM and melanoma. Thus, we investigated the mechanism of NG2 mediated malignant progression and its potential as a therapeutic target in clinically relevant GBM and melanoma animal models. Xenografting NG2 overexpressing GBM cell lines resulted in increased growth rate, angiogenesis and vascular permeability compared to control, NG2 negative tumours. The effect of abrogating NG2 function was investigated after intracerebral delivery of lentivirally encoded shRNAs targeting NG2 in patient GBM xenografts as well as in established subcutaneous A375 melanoma tumours. NG2 knockdown reduced melanoma proliferation and increased apoptosis and necrosis. Targeting NG2 in two heterogeneous GBM xenografts significantly reduced tumour growth and oedema levels, angiogenesis and normalised vascular function. Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy.

  19. The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

    Science.gov (United States)

    Urbańska, Kaja; Pająk, Beata; Orzechowski, Arkadiusz; Sokołowska, Justyna; Grodzik, Marta; Sawosz, Ewa; Szmidt, Maciej; Sysa, Paweł

    2015-03-01

    Recently, it has been shown that silver nanoparticles (AgNPs) provide a unique approach to the treatment of tumors, especially those of neuroepithelial origin. Thus, the aim of this study was to evaluate the impact of AgNPs on proliferation and activation of the intrinsic apoptotic pathway of glioblastoma multiforme (GBM) cells cultured in an in ovo model. Human GBM cells, line U-87, were placed on chicken embryo chorioallantoic membrane. After 8 days, the tumors were divided into three groups: control (non-treated), treated with colloidal AgNPs (40 μg/ml), and placebo (tumors supplemented with vehicle only). At the end of the experiment, all tumors were isolated. Assessment of cell proliferation and cell apoptosis was estimated by histological, immunohistochemical, and Western blot analyses. The results show that AgNPs can influence GBM growth. AgNPs inhibit proliferation of GBM cells and seem to have proapoptotic properties. Although there were statistically significant differences between control and AgNP groups in the AI and the levels of active caspase 9 and active caspase 3, the level of these proteins in GBM cells treated with AgNPs seems to be on the border between the spontaneous apoptosis and the induced. Our results indicate that the antiproliferative properties of silver nanoparticles overwhelm proapoptotic ones. Further research focused on the cytotoxic effect of AgNPs on tumor and normal cells should be conducted.

  20. The Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Stanbro, M.; Briggs, M. S.; Roberts, O.; McBreen, S.; Bhat, N.; Fitzpatrick, G.

    2015-12-01

    We present results from the catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope. The first release, in January 2015, provided data on 2700 TGFs. Updates are extending the catalog at a rate of ~800 TGFs per year. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and other Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs). In January 2016 additional data will be released online from correlating these TGFs with sferics detected by the World Wide Lightning Location Network (WWLLN). Maps of sferics in the vicinity of each TGF will be provided, as will the locations and times of sferics found to be associated with TGFs.

  1. New Methods for Timing Analysis of Transient Events, Applied to Fermi/GBM Magnetar Bursts

    CERN Document Server

    Huppenkothen, Daniela; Uttley, Phil; van der Horst, Alexander J; van der Klis, Michiel; Kouveliotou, Chryssa; Gogus, Ersin; Granot, Jonathan; Vaughan, Simon; Finger, Mark H

    2013-01-01

    In order to discern the physical nature of many gamma-ray sources in the sky, we must look not only in spectral and spatial dimensions, but also understand their temporal variability. However, timing analysis of sources with a highly transient nature, such as magnetar bursts, is difficult: standard Fourier techniques developed for long-term variability generally observed, for example, from AGN often do not apply. Here, we present newly developed timing methods applicable to transient events of all kinds, and show their successful application to magnetar bursts observed with Fermi/GBM. Magnetars are a prime subject for timing studies, thanks to the detection of quasi-periodicities in magnetar Giant Flares and their potential to help shed light on the structure of neutron stars. Using state-of-the art statistical techniques, we search for quasi-periodicities (QPOs) in a sample of bursts from Soft Gamma Repeater SGR J0501+4516 observed with Fermi/GBM and provide upper limits for potential QPO detections. Additio...

  2. Gravitational wave observations may constrain gamma-ray burst models: the case of GW 150914 - GBM

    CERN Document Server

    Veres, P; Goldstein, A; Mészáros, P; Burns, E; Connaughton, V

    2016-01-01

    The possible short gamma-ray burst (GRB) observed by {\\it Fermi}/GBM in coincidence with the first gravitational wave (GW) detection, offers new ways to test GRB prompt emission models. Gravitational wave observations provide previously unaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW~150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density ($\\sim 10^{-3}$ cm$^{-3}$) and a high Lorentz factor ($\\sim 2000$). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Bl...

  3. Tumour Relapse Prediction Using Multiparametric MR Data Recorded during Follow-Up of GBM Patients

    Directory of Open Access Journals (Sweden)

    Adrian Ion-Margineanu

    2015-01-01

    Full Text Available Purpose. We have focused on finding a classifier that best discriminates between tumour progression and regression based on multiparametric MR data retrieved from follow-up GBM patients. Materials and Methods. Multiparametric MR data consisting of conventional and advanced MRI (perfusion, diffusion, and spectroscopy were acquired from 29 GBM patients treated with adjuvant therapy after surgery over a period of several months. A 27-feature vector was built for each time point, although not all features could be obtained at all time points due to missing data or quality issues. We tested classifiers using LOPO method on complete and imputed data. We measure the performance by computing BER for each time point and wBER for all time points. Results. If we train random forests, LogitBoost, or RobustBoost on data with complete features, we can differentiate between tumour progression and regression with 100% accuracy, one time point (i.e., about 1 month earlier than the date when doctors had put a label (progressive or responsive according to established radiological criteria. We obtain the same result when training the same classifiers solely on complete perfusion data. Conclusions. Our findings suggest that ensemble classifiers (i.e., random forests and boost classifiers show promising results in predicting tumour progression earlier than established radiological criteria and should be further investigated.

  4. Magnetar Twists: Fermi/Gamma ray Burst Monitor (GBM) detection of SGR 1550-5418

    CERN Document Server

    Kaneko, Y; Kouveliotou, C; Ramirez-Ruiz, E; Granot, J; van der Horst, A J; Watts, A L; Finger, M H; Gehrels, N; Pe'er, A; van der Klis, M; von Kienlin, A; Wachter, S; Wilson-Hodge, C A; Woods, P M

    2009-01-01

    SGR 1550-5418 (previously known as AXP 1E 1547.0-5408) went into three active bursting episodes in 2008 October and in 2009 January and March, emitting hundreds of typical Soft Gamma Repeater (SGR) bursts in soft gamma rays. The second episode was especially intense, and our untriggered burst search on Fermi/GBM data (8-1000 keV) revealed ~450 bursts emitted over 24 hours during the peak of this activity. Using the GBM data, we identified a ~150-s-long enhanced persistent emission during 2009 January 22 that exhibited intriguing timing and spectral properties: (i) clear pulsations up to ~110 keV at the spin period of the neutron star (P ~2.07 s, the fastest of all magnetars), (ii) an additional (to a power-law) blackbody component required for the enhanced emission spectra with kT ~17 keV, (iii) pulsed fraction that is strongly energy dependent and highest in the 50-74 keV energy band. A total isotropic-equivalent energy emitted during this enhanced emission is estimated to be 4.3 x 10^{40} ergs. We conclude ...

  5. $Fermi$ GBM Observations of V404 Cyg During its 2015 Outburst

    CERN Document Server

    Jenke, P A; Homan, Jeroen; Veres, P; Briggs, M S; Burns, E; Connaughton, V; Finger, M H; Hui, M

    2016-01-01

    V404 Cygni was discovered in 1989 by the $Ginga$ X-ray satellite during its only previously observed X-ray outburst and soon after confirmed as a black hole binary. On June 15, 2015, the Gamma Ray Burst Monitor (GBM) triggered on a new outburst of V404 Cygni. We present 13 days of GBM observations of this latest outburst including Earth occultation flux measurements, spectral and temporal analysis. The Earth occultation fluxes reached 30 Crab with detected emission to 100 keV and determined, via hardness ratios, that the source was in a hard state. At high luminosity, spectral analysis between 8 and 300 keV showed that the electron temperature decreased with increasing luminosity. This is expected if the protons and electrons are in thermal equilibrium during an outburst with the electrons cooled by the Compton scattering of softer seed photons from the disk. However, the implied seed photon temperatures are unusually high, suggesting a contribution from another source, such as the jet. No evidence of state t...

  6. Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines.

    Science.gov (United States)

    Reichrath, Sandra; Müller, Cornelia S L; Gleissner, Beate; Pfreundschuh, Michael; Vogt, Thomas; Reichrath, Jörg

    2010-07-01

    Recently, an important role of Notch activation for Ras-induced transformation of glial cells and for glioma growth and survival has been demonstrated. It was concluded that activation of Notch-signaling may represent a new target for glioblastoma multiforme (GBM) therapy. We now analyzed five GBM cell lines (Tx3095, Tx3868, U87, U118, U373) for key components of Notch-signaling pathways (Notch-1, Notch-2, Notch-3, Notch-4, Delta-like 1, Delta-like 3, Delta-like 4, Jagged-1, Jagged-2) using conventional RT-PCR. We found that some components (Notch-1, Notch-2, Notch-4, Jagged-1) were consistently expressed in all cell lines analyzed while, in contrast, other key components of Notch-signaling were differentially expressed. Notch-3 was expressed in three out of five cell lines (in U87, U118 and U373), but was missing in Tx3095 and Tx3868 cells. Jagged-2 was expressed in U87, U373 and Tx3868, but not in U118 or Tx3095 cells. Delta-like 1 and Delta-like 3 were not detected in Tx3905 cells, but in all other cell lines. RNA for Delta-like 4 was only found in U373 and Tx3868 GBM cell lines. Treating GBM cell lines with 1,25(OH)2D3 (10(-6), 10(-8), and 10(-10) M), the biologically active form of vitamin D, did not result in significant dose- or time-dependent antiproliferative effects, indicating that GBM cell lines are resistant against the antiproliferative activity of 1,25(OH)2D3. In vitro treatment of GBM cells with 1,25(OH)2D3 did not result in a modulation of the expression of key components of the Notch-signaling pathway. Treatment with HDAC-inhibitor TSA or DNA-methyltransferase inhibitor 5-aza exerted dose- and time-dependent antiproliferative effects on GBM cell lines. We asked the question whether the resistance against 1,25(OH)2D3 could be restored by co-treatment with TSA or 5-aza. However, combination therapy with 1,25(OH)2D3 and TSA or 5-aza did not result in enhanced antiproliferative effects as compared to treatment with TSA or 5-aza alone. In contrast

  7. Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

    Directory of Open Access Journals (Sweden)

    Monticone Massimiliano

    2012-08-01

    Full Text Available Abstract Background Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting. We noticed that our long-term GBM cultures, established from different patients, may display two categories/types of growth behavior in an orthotopic xenograft model: expansion of the tumor mass and formation of tumor branches/nodules (nodular like, NL-type or highly diffuse single tumor cell infiltration (HD-type. Methods We determined by DNA microarrays the gene expression profiles of three NL-type and three HD-type long-term GBM cultures. Subsequently, individual genes with different expression levels between the two groups were identified using Significance Analysis of Microarrays (SAM. Real time RT-PCR, immunofluorescence and immunoblot analyses, were performed for a selected subgroup of regulated gene products to confirm the results obtained by the expression analysis. Results Here, we report the identification of a set of 34 differentially expressed genes in the two types of GBM cultures. Twenty-three of these genes encode for proteins localized to the plasma membrane and 9 of these for proteins are involved in the process of cell adhesion. Conclusions This study suggests the participation in the diffuse infiltrative/invasive process of GBM cells within the CNS of a novel set of genes coding for membrane-associated proteins, which should be thus susceptible to an inhibition strategy by specific targeting. Massimiliano Monticone and Antonio Daga contributed equally to this work

  8. Swift/BAT and Fermi/GBM observations of SGR J1935+2154 bursts

    Science.gov (United States)

    Lin, Lin

    2016-07-01

    SGR J1935+2154 is a new member of the magnetar family. It was discovered from a short burst which triggered Swift/BAT on 2014 July 5. In 2015 February, the source was detected in the burst active episode again which lasted for about 11 days. We searched for magnetar burst using Bayesian Blocks method through Swift/BAT and Fermi/GBM observations, and totally found 27 events including 3 in 2014 and 24 in 2015. In this talk we will present the result of our detailed analysis of the temporal and spectral properties of these short bursts, and briefly discuss the connection between burst activity and the persistent emission of the source.

  9. Main Memory

    NARCIS (Netherlands)

    P.A. Boncz (Peter); L. Liu (Lei); M. Tamer Özsu

    2008-01-01

    htmlabstractPrimary storage, presently known as main memory, is the largest memory directly accessible to the CPU in the prevalent Von Neumann model and stores both data and instructions (program code). The CPU continuously reads instructions stored there and executes them. It is also called Random

  10. CADrx for GBM Brain Tumors: Predicting Treatment Response from Changes in Diffusion-Weighted MRI

    Directory of Open Access Journals (Sweden)

    Matthew S. Brown

    2009-11-01

    Full Text Available The goal of this study was to develop a computer-aided therapeutic response (CADrx system for early prediction of drug treatment response for glioblastoma multiforme (GBM brain tumors with diffusion weighted (DW MR images. In conventional Macdonald assessment, tumor response is assessed nine weeks or more post-treatment. However, we will investigate the ability of DW-MRI to assess response earlier, at five weeks post treatment. The apparent diffusion coefficient (ADC map, calculated from DW images, has been shown to reveal changes in the tumor’s microenvironment preceding morphologic tumor changes. ADC values in treated brain tumors could theoretically both increase due to the cell kill (and thus reduced cell density and decrease due to inhibition of edema. In this study, we investigated the effectiveness of features that quantify changes from pre- and post-treatment tumor ADC histograms to detect treatment response. There are three parts to this study: first, tumor regions were segmented on T1w contrast enhanced images by Otsu’s thresholding method, and mapped from T1w images onto ADC images by a 3D region of interest (ROI mapping tool using DICOM header information; second, ADC histograms of the tumor region were extracted from both pre- and five weeks post-treatment scans, and fitted by a two-component Gaussian mixture model (GMM. The GMM features as well as standard histogram-based features were extracted. Finally, supervised machine learning techniques were applied for classification of responders or non-responders. The approach was evaluated with a dataset of 85 patients with GBM under chemotherapy, in which 39 responded and 46 did not, based on tumor volume reduction. We compared adaBoost, random forest and support vector machine classification algorithms, using ten-fold cross validation, resulting in the best accuracy of 69.41% and the corresponding area under the curve (Az of 0.70.

  11. Searching the Gamma-ray Sky for Counterparts to Gravitational Wave Sources: Fermi GBM and LAT Observations of LVT151012 and GW151226

    CERN Document Server

    Racusin, J L; Goldstein, A; Connaughton, V; Wilson-Hodge, C A; Jenke, P; Blackburn, L; Briggs, M S; Broida, J; Camp, J; Christensen, N; Hui, C M; Littenberg, T; Shawhan, P; Singer, L; Veitch, J; Bhat, P N; Cleveland, W; Fitzpatrick, G; Gibby, M H; von Kienlin, A; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O J; Stanbro, M; Veres, P; Zhang, B -B; Ackermann, M; Albert, A; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Bellazzini, R; Bissaldi, E; Blandford, R D; Bloom, E D; Bonino, R; Bregeon, J; Bruel, P; Buson, S; Caliandro, G A; Cameron, R A; Caputo, R; Caragiulo, M; Caraveo, P A; Cavazzuti, E; Charles, E; Chiang, J; Ciprini, S; Costanza, F; Cuoco, A; Cutini, S; D'Ammando, F; de Palma, F; Desiante, R; Digel, S W; Di Lalla, N; Di Mauro, M; Di Venere, L; Drell, P S; Favuzzi, C; Ferrara, E C; Focke, W B; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Giglietto, N; Gill, R; Giroletti, M; Glanzman, T; Granot, J; Green, D; Grove, J E; Guillemot, L; Guiriec, S; Harding, A K; Jogler, T; Johannesson, G; Kamae, T; Kensei, S; Kocevski, D; Kuss, M; Larsson, S; Latronico, L; Li, J; Longo, F; Loparco, F; Lubrano, P; Magill, J D; Maldera, S; Malyshev, D; McEnery, J E; Michelson, P F; Mizuno, T; Morselli, A; Moskalenko, I V; Negro, M; Nuss, E; Omodei, N; Orienti, M; Orlando, E; Ormes, J F; Paneque, D; Perkins, J S; Pesce-Rollins, M; Piron, F; Pivato, G; Porter, T A; Principe, G; Raino, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Parkinson, P M Saz; Scargle, J D; Sgro, C; Simone, D; Siskind, E J; Smith, D A; Spada, F; Spinelli, P; Suson, D J; Tajima, H; Thayer, J B; Torres, D F; Troja, E; Uchiyama, Y; Vianello, G; Wood, K S; Wood, M

    2016-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candi- date LVT151012. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for char- acterizing the upper limits across a large area of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, dif- ferences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

  12. DISTRIBUTION OF GBM HEPARAN-SULFATE PROTEOGLYCAN CORE PROTEIN AND SIDE-CHAINS IN HUMAN GLOMERULAR-DISEASES

    NARCIS (Netherlands)

    VANDENBORN, J; VANDENHEUVEL, LPWJ; BAKKER, MAH; VEERKAMP, JH; ASSMANN, KJM; WEENING, JJ; BERDEN, JHM

    1993-01-01

    Using monoclonal antibodies (mAbs) recognizing either the core protein or the heparan sulfate (HS) side chain of human GBM heparan sulfate proteoglycan (HSPG), we investigated their glomerular distribution on cryostat sections of human kidney tissues. The study involved 95 biopsies comprising twelve

  13. Main Memory

    OpenAIRE

    Boncz, Peter; Liu, Lei; Özsu, Tamer, M.

    2008-01-01

    Primary storage, presently known as main memory, is the largest memory directly accessible to the CPU in the prevalent Von Neumann model and stores both data and instructions (program code). The CPU continuously reads instructions stored there and executes them. It is also called Random Access Memory (RAM), to indicate that load/store instructions can access data at any location at the same cost, is usually implemented using DRAM chips, which are connected to the CPU and other peripherals (di...

  14. Response assessment of bevacizumab therapy in GBM with integrated 11C-MET-PET/MRI: a feasibility study.

    Science.gov (United States)

    Deuschl, Cornelius; Moenninghoff, Christoph; Goericke, Sophia; Kirchner, Julian; Köppen, Susanne; Binse, Ina; Poeppel, Thorsten D; Quick, Harald H; Forsting, Michael; Umutlu, Lale; Herrmann, Ken; Hense, Joerg; Schlamann, Marc

    2017-08-01

    The objective of this study was to evaluate the potential of integrated 11C-MET PET/MR for response assessment of relapsed glioblastoma (GBM) receiving bevacizumab treatment. Eleven consecutive patients with relapsed GBM were enrolled for an integrated 11C-MET PET/MRI at baseline and at follow-up. Treatment response for MRI was evaluated according to Response Assessment in Neuro-oncology (RANO) criteria and integrated 11C-MET PET was assessed by the T/N ratio. MRI showed no patient with complete response (CR), six of 11 patients with PR, four of 11 patients with SD, and one of 11 patients with progressive disease (PD). PET revealed metabolic response in five of the six patients with partial response (PR) and in two of the four patients with stable disease (SD), whereas metabolic non-response was detected in one of the six patients with PR, in two of the four patients with SD, and in the one patient with PD. Morphological imaging was predictive for PFS and OS when response was defined as CR, PR, SD, and non-response as PD. Metabolic imaging was predictive when using T/N ratio reduction of >25 as discriminator. Based on the morphologic and metabolic findings of this study a proposal for applying integrated PET/MRI for treatment response in relapsed GBM was developed, which was significantly predictive for PFS and OS (P = 0.010 respectively 0,029, log). This study demonstrates the potential of integrated 11C-MET-PET/MRI for response assessment of GBM and the utility of combined assessment of morphologic and metabolic information with the proposal for assessing relapsed GBM.

  15. MAXIMIZATION OF DNA DAMAGE TO MGMT(+ EGFR(+ GBM CELLS USING OPTIMAL COMBINATION OF TEMOZOLOMIDE-ANTI EGFR MONOCLONAL ANTIBODY NIMOTUZUMAB

    Directory of Open Access Journals (Sweden)

    M. A. M. Inggas

    2015-09-01

    Full Text Available Background: Glioblastoma multiforme (GBM is the most aggressive primary brain tumor in adultswith dismal prognosis due to the unavailability of an effective therapy. Up to now, there had been no definitive studies published on EGFR inhibition therapy as a chemosensitizer for GBM therapy using Temozolomide (TMZ. This study aims to reveal the most effective method and timing to administer TMZ-anti EGFR targeted therapy which causes maximal DNA damage on GBM cells.Methods: Various regimens of anti EGFR monoclonal antibody Nimotuzumab (NMZ was administered in different combinations with TMZ, performed on U87MG MGMT(+ EGFR(+ cells. The effectiveness of the combinations were evaluated by measuring yH2AX levels which reflects the degree of DNA damage. One-way Anova and LSD tests were performed to determine the effects of each treatment with p<0.05. Results and discussion: the mean SD of yH2AX of each treatment was: 11,90±1,25 for the control group; 29.33±1.91 for NMZ alone; 28.13±1.58 for TMZ alone; 41.53±3.51 for concurrent use; 35.67 ±2.65 for NMZ after 24 hours TMZ; 31.87±2.94 for NMZ after 48 hours TMZ; 39.57±4.2 for TMZ after 24 hours NMZ; and 35.93 ±3.56 for TMZ after 48 hours NMZ. The administration of TMZ concurrent with or after 24 hours NMZ gives the highest amount of DNA damage to GBM cells. Conclusion: The administration of Nimotuzumab targeted therapy up to 24 hours before Temozolomide chemotherapy has been proven to be effective in maximizing the amount of DNA damage done to GBM cells in vitro. 

  16. MAIN CONTENTS

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The Key to Agricultural Science and Technology Innovation should be placed on the FiveMajor Changes Based on analysis and forecasting on grain consumption influencing factors, production influencing factors and import influencing factors, the supply and demand of main sorts of grain in China is forecas- ted respectively, including paddy, wheat, corn and soybean. In 2020, grain consumption quantity, grain production quantity and grain import quantity of China is 693 million tons, 644 million tons and 49 million tons respectively. For grain security in future, new stratagem on food security should be im- plemented, grain import circumstance and global grain security. Father mechanism should be im- proved, and early warning and regulation on grain production capacity should be paid attention to sys- temically.

  17. The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years Of Data

    CERN Document Server

    Gruber, David; von Ahlefeld, Victoria Weller; Bhat, P Narayana; Bissaldi, Elisabetta; Briggs, Michael S; Byrne, Dave; Cleveland, William H; Connaughton, Valerie; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty M; Greiner, Jochen; Guiriec, Sylvain; van der Horst, Alexander J; von Kienlin, Andreas; Kouveliotou, Chryssa; Layden, Emily; Lin, Lin; Meegan, Charles A; McGlynn, Sinéad; Paciesas, William S; Pelassa, Véronique; Preece, Robert D; Rau, Arne; Wilson-Hodge, Colleen A; Xiong, Shaolin; Yu, Hoi-Fung

    2014-01-01

    In this catalog we present the updated set of spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years of operation. It contains two types of spectra, time-integrated spectral fits and spectral fits at the brightest time bin, from 943 triggered GRBs. Four different spectral models were fitted to the data, resulting in a compendium of more than 7500 spectra. The analysis was performed similarly, but not identically to Goldstein et al. 2012. All 487 GRBs from the first two years have been re-fitted using the same methodology as that of the 456 GRBs in years three and four. We describe, in detail, our procedure and criteria for the analysis, and present the results in the form of parameter distributions both for the observer-frame and rest-frame quantities. The data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  18. Restriction spectrum imaging of bevacizumab-related necrosis in a patient with GBM

    Directory of Open Access Journals (Sweden)

    Nikdokht eFarid

    2013-09-01

    Full Text Available Importance:With the increasing use of antiangiogenic agents in the treatment of high grade gliomas, we are becoming increasingly aware of distinctive imaging findings seen in a subset of patients treated with these agents. Of particular interest is the development of regions of marked and persistent restricted diffusion. We describe a case with histopathologic validation, confirming that this region of restricted diffusion represents necrosis and not viable tumor. Observations:We present a case report of a 52-year-old man with GBM treated with temozolomide, radiation, and concurrent bevacizumab following gross total resection. The patient underwent sequential MRI's which included restriction-spectrum imaging (RSI, an advanced diffusion-weighted imaging (DWI technique, and MR perfusion. Following surgery, the patient developed an area of restricted diffusion on RSI which became larger and more confluent over the next several months. Marked signal intensity on RSI and very low cerebral blood volume (CBV on MR perfusion led us to favor bevacizumab-related necrosis over recurrent tumor. Subsequent histopathologic evaluation confirmed coagulative necrosis.Conclusions and Relevance:Our report increases the number of pathologically-proven cases of bevacizumab-related necrosis in the literature from three to four. Furthermore, our case demonstrates this phenomenon on RSI, which has been shown to have good sensitivity to restricted diffusion.

  19. GBM Volumetry using the 3D Slicer Medical Image Computing Platform

    Science.gov (United States)

    Egger, Jan; Kapur, Tina; Fedorov, Andriy; Pieper, Steve; Miller, James V.; Veeraraghavan, Harini; Freisleben, Bernd; Golby, Alexandra J.; Nimsky, Christopher; Kikinis, Ron

    2013-01-01

    Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer – a free platform for biomedical research – provides an alternative to this manual slice-by-slice segmentation process, which is significantly faster and requires less user interaction. In this study, 4 physicians segmented GBMs in 10 patients, once using the competitive region-growing based GrowCut segmentation module of Slicer, and once purely by drawing boundaries completely manually on a slice-by-slice basis. Furthermore, we provide a variability analysis for three physicians for 12 GBMs. The time required for GrowCut segmentation was on an average 61% of the time required for a pure manual segmentation. A comparison of Slicer-based segmentation with manual slice-by-slice segmentation resulted in a Dice Similarity Coefficient of 88.43 ± 5.23% and a Hausdorff Distance of 2.32 ± 5.23 mm. PMID:23455483

  20. GBM Monitoring of Cyg X-1 During the Recent State Transition

    CERN Document Server

    Case, G L; Cherry, M L; Camero-Arranz, A; Finger, M; Jenke, P; Wilson-Hodge, C A; Chaplin, V

    2011-01-01

    Cygnus X-1 is a high-mass x-ray binary with a black hole compact object. It is normally extremely bright in hard x-rays and low energy gamma rays and resides in the canonical hard spectral state. Recently, however, Cyg X-1 made a transition to the canonical soft state, with a rise in the soft x-ray flux and a decrease in the flux in the hard x-ray and low energy gamma-ray energy bands. We have been using the Gamma-Ray Burst Monitor on Fermi to monitor the fluxes of a number of sources in the 8--1000 keV energy range, including Cyg X-1. We present light curves of Cyg X-1 showing the flux decrease in hard x-ray and low energy gamma-ray energy bands during the state transition as well as the several long flares observed in these higher energies during the soft state. We also present preliminary spectra from GBM for the pre-transition state, showing the spectral evolution to the soft state, and the post-transition state.

  1. Testing the anisotropy in the angular distribution of $Fermi$/GBM gamma-ray bursts

    CERN Document Server

    Tarnopolski, Mariusz

    2015-01-01

    Gamma-ray bursts (GRBs) were confirmed to be of extragalactic origin due to their isotropic angular distribution, combined with the fact that they exhibited an intensity distribution that deviated strongly from the $-3/2$ power law. This finding was later confirmed with the first redshift, equal to at least $z=0.835$, measured for GRB970508. Despite this result, the data from $CGRO$/BATSE and $Swift$/BAT indicate that long GRBs are indeed distributed isotropically, but the distribution of short GRBs is anisotropic. $Fermi$/GBM has detected 1669 GRBs up to date, and their sky distribution is examined in this paper. A number of statistical tests is applied: nearest neighbour analysis, fractal dimension, dipole and quadrupole moments of the distribution function decomposed into spherical harmonics, binomial test, and the two point angular correlation function. Monte Carlo benchmark testing of each test is performed in order to evaluate its reliability. It is found that short GRBs are distributed anisotropically ...

  2. A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients

    Science.gov (United States)

    Raizer, J. J.; Giglio, P.; Hu, J.; Groves, M.; Merrell, R.; Conrad, C.; Phuphanich, S.; Puduvalli, V. K.; Loghin, M.; Paleologos, N.; Yuan, Y.; Liu, D.; Rademaker, A.; Yung, W. K.; Vaillant, B.; Rudnick, J.; Chamberlain, M.; Vick, N.; Grimm, S.; Tremont-Lukats, I. W.; De Groot, J.; Aldape, K.; Gilbert, M. R.

    2016-01-01

    Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is limited. How to better treat patients with unmethylated MGMT is unknown. We performed a trial combining erlotinib and bevacizumab in unmethylated GBM patients after completion of radiation (RT) and TMZ. GBM patients with an unmethylated MGMT promoter were trial eligible. Patient received standard RT (60 Gy) and TMZ (75 mg/m2 × 6 weeks) after surgical resection of their tumor. After completion of RT they started erlotinib 150 mg daily and bevacizumab 10 mg/kg every 2 weeks until progression. Imaging evaluations occurred every 8 weeks. The primary endpoint was overall survival. Of the 48 unmethylated patients enrolled, 46 were evaluable (29 men and 17 women); median age was 55.5 years (29–75) and median KPS was 90 (70–100). All patients completed RT with TMZ. The median number of cycles (1 cycle was 4 weeks) was 8 (2–47). Forty-one patients either progressed or died with a median progression free survival of 9.2 months. At a follow up of 33 months the median overall survival was 13.2 months. There were no unexpected toxicities and most observed toxicities were categorized as CTC grade 1 or 2. The combination of erlotinib and bevacizumab is tolerable but did not meet our primary endpoint of increasing survival. Importantly, more trials are needed to find better therapies for GBM patients with an unmethylated MGMT promoter. PMID:26476729

  3. Test of the Weak Equivalence Principle using LIGO observations of GW150914 and Fermi observations of GBM transient 150914

    Directory of Open Access Journals (Sweden)

    Molin Liu

    2017-07-01

    Full Text Available About 0.4 s after the Laser Interferometer Gravitational-Wave Observatory (LIGO detected a transient gravitational-wave (GW signal GW150914, the Fermi Gamma-ray Burst Monitor (GBM also found a weak electromagnetic transient (GBM transient 150914. Time and location coincidences favor a possible association between GW150904 and GBM transient 150914. Under this possible association, we adopt Fermi's electromagnetic (EM localization and derive constraints on possible violations of the Weak Equivalence Principle (WEP from the observations of two events. Our calculations are based on four comparisons: (1 The first is the comparison of the initial GWs detected at the two LIGO sites. From the different polarizations of these initial GWs, we obtain a limit on any difference in the parametrized post-Newtonian (PPN parameter Δγ≲10−10. (2 The second is a comparison of GWs and possible EM waves. Using a traditional super-Eddington accretion model for GBM transient 150914, we again obtain an upper limit Δγ≲10−10. Compared with previous results for photons and neutrinos, our limits are five orders of magnitude stronger than those from PeV neutrinos in blazar flares, and seven orders stronger than those from MeV neutrinos in SN1987A. (3 The third is a comparison of GWs with different frequencies in the range [35 Hz, 250 Hz]. (4 The fourth is a comparison of EM waves with different energies in the range [1 keV, 10 MeV]. These last two comparisons lead to an even stronger limit, Δγ≲10−8. Our results highlight the potential of multi-messenger signals exploiting different emission channels to strengthen existing tests of the WEP.

  4. Improved limits on sterile neutrino dark matter from full-sky observations by the Fermi-GBM

    CERN Document Server

    Horiuchi, Shunsaku; Gaskins, Jennifer M; Smith, Miles; Preece, Robert

    2015-01-01

    For the first time, we use the Gamma-ray Burst Monitor (GBM) on-board the Fermi satellite to search for sterile neutrino decay lines in the energy range 10-25 keV corresponding to sterile neutrino mass range 20-50 keV. This energy range has been out of reach of traditional X-ray satellites such as Chandra, Suzaku, XMM-Newton, and gamma-ray satellites such as INTEGRAL. Furthermore, the extremely wide field of view of the GBM opens a large fraction of the Milky Way dark matter halo to be probed. We start with 1601 days worth of GBM data, implement stringent data cuts, and perform two simple line search analyses on the reduced data: in the first, the line flux is limited without background modeling, and in the second, the background is modeled as a power-law. We find no significant excess lines in both our searches. We set new limits on sterile neutrino mixing angles, improving on previous limits by approximately an order of magnitude. Better understanding of detector and astrophysical backgrounds, as well as de...

  5. HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells.

    Science.gov (United States)

    Booth, Laurence; Roberts, Jane L; Conley, Adam; Cruickshanks, Nichola; Ridder, Thomas; Grant, Steven; Poklepovic, Andrew; Dent, Paul

    2014-03-01

    The present studies determined whether the antibiotic salinomycin interacted with HDAC inhibitors to kill primary human GBM cells. Regardless of PTEN, ERBB1, or p53 mutational status salinomycin interacted with HDAC inhibitors in a synergistic fashion to kill GBM cells. Inhibition of CD95/Caspase 8 or of CD95/RIP-1/AIF signaling suppressed killing by the drug combination. Salinomycin increased the levels of autophagosomes that correlated with increased p62 and LC3II levels; valproate co-treatment correlated with reduced LC3II and p62 expression, and increased caspase 3 cleavage. Molecular inhibition of autophagosome formation was protective against drug exposure. The drug combination enhanced eIF2α phosphorylation and decreased expression of MCL-1 and phosphorylation of mTOR and p70 S6K. Activation of p70 S6K or mTOR promoted cell survival in the face of combined drug exposure. Overexpression of BCL-XL or c-FLIP-s was protective. Collectively our data demonstrate that the lethality of low nanomolar concentrations of salinomycin are enhanced by HDAC inhibitors in GBM cells and that increased death receptor signaling together with reduced mitochondrial function are causal in the combinatorial drug necro-apoptotic killing effect.

  6. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model

    Directory of Open Access Journals (Sweden)

    Bente Sandvei Skeie

    2013-01-01

    Full Text Available Object. Gamma knife surgery (GKS may be used for recurring glioblastomas (GBMs. However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments. Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS. Methods. GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI. The rats were allocated to GKS, with margin doses of 12 Gy or 18 Gy, or to no treatment. Survival time was recorded, tumor sections were examined, and radiotoxicity was evaluated in a behavioral open field test. Results. In the first series, survival from the time of implantation was 96 days in treated rats and 72 days in controls (P<0.001. In a second experiment, survival was 72 days in the treatment group versus 54 days in controls (P<0.006. Polynuclear macrophages and fibrosis was seen in groups subjected to GKS. Untreated rats with GBM xenografts displayed less mobility than GKS-treated animals in the open field test 4 weeks after treatment (P=0.04. Conclusion. GKS administered with clinically relevant doses prolongs survival in rats harboring GBM xenografts, and the associated toxicity is mild.

  7. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Wilson-Hodge, Colleen A; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Jenke, Peter; Chaplin, Vandiver; Beklen, Elif; Finger, Mark; Bhat, Narayan; Briggs, Michael S; Connaughton, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2012-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 102 sources, including 41 low-mass X-ray binary/neutron star systems, 33 high-mass X-ray binary neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found at http://heastro.phys.lsu.edu/gbm/.

  8. The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

    CERN Document Server

    Lipunov, V M; Pruzhinskaya, M V; Postigo, A de Ugarte; Pelassa, V; Tsvetkova, A E; Sokolov, I V; Kann, D A; Xu, Dong; Gorbovskoy, E S; Krushinski, V V; Kornilov, V G; Balanutsa, P V; Boronina, S V; Budnev, N M; Cano, Z; Castro-Tirado, A J; Chazov, V V; Connaughton, V; Delvaux, C; Frederiks, D D; Fynbo, J F U; Gabovich, A V; Goldstein, A; Greiner, J; Gress, O A; Ivanov, K I; Jakobsson, P; Klose, S; Knust, F; Komarova, V N; Konstantinov, E; Krylov, A V; Kuvshinov, D A; Kuznetsov, A S; Lipunova, G V; Moskvitin, A S; Pal'shin, V D; Pandey, S B; Poleshchuk, V A; Schmidl, S; Sergienko, Yu P; Sinyakov, E V; Schulze, S; Sokolov, V V; Sokolova, T N; Sparre, M; Thone, C C; Tlatov, A G; Tyurina, N V; Ulanov, M V; Yazev, S A; Yurkov, V V

    2015-01-01

    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg$^2$ 3-$\\sigma$ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of $z=1.32$. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is $E_\\mathrm{iso} = 5.54_{-0.24}^{+0.26} \\times 10^{52}$ erg and $E_\\mathrm{p, rest}\\simeq280$ keV,...

  9. A Novel GBM Saliency Detection Model Using Multi-Channel MRI.

    Directory of Open Access Journals (Sweden)

    Subhashis Banerjee

    Full Text Available The automatic computerized detection of regions of interest (ROI is an important step in the process of medical image processing and analysis. The reasons are many, and include an increasing amount of available medical imaging data, existence of inter-observer and inter-scanner variability, and to improve the accuracy in automatic detection in order to assist doctors in diagnosing faster and on time. A novel algorithm, based on visual saliency, is developed here for the identification of tumor regions from MR images of the brain. The GBM saliency detection model is designed by taking cue from the concept of visual saliency in natural scenes. A visually salient region is typically rare in an image, and contains highly discriminating information, with attention getting immediately focused upon it. Although color is typically considered as the most important feature in a bottom-up saliency detection model, we circumvent this issue in the inherently gray scale MR framework. We develop a novel pseudo-coloring scheme, based on the three MRI sequences, viz. FLAIR, T2 and T1C (contrast enhanced with Gadolinium. A bottom-up strategy, based on a new pseudo-color distance and spatial distance between image patches, is defined for highlighting the salient regions in the image. This multi-channel representation of the image and saliency detection model help in automatically and quickly isolating the tumor region, for subsequent delineation, as is necessary in medical diagnosis. The effectiveness of the proposed model is evaluated on MRI of 80 subjects from the BRATS database in terms of the saliency map values. Using ground truth of the tumor regions for both high- and low- grade gliomas, the results are compared with four highly referred saliency detection models from literature. In all cases the AUC scores from the ROC analysis are found to be more than 0.999 ± 0.001 over different tumor grades, sizes and positions.

  10. Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-GBM autoantibodies specific for α345NC1 hexamers

    Science.gov (United States)

    Olaru, Florina; Wang, Xu-Ping; Luo, Wentian; Ge, Linna; Miner, Jeffrey H; Kleinau, Sandra; Geiger, Xochiquetzal J.; Wasiluk, Andrew; Heidet, Laurence; Kitching, A. Richard; Borza, Dorin-Bogdan

    2012-01-01

    Goodpasture disease is an autoimmune kidney disease mediated by autoAbs against NC1 monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis. We identified a novel type of human IgG4-restricted anti-GBM autoAbs associated with mild non-progressive glomerulonephritis, which specifically targeted α345NC1 hexamers but not α3NC1 monomers. The mechanisms eliciting these anti-GBM autoAbs were investigated in mouse models recapitulating this phenotype. Wild type and FcγRIIB−/− mice immunized with autologous murine GBM NC1 hexamers produced mouse IgG1-restricted autoAbs specific for α345NC1 hexamers, which bound to the GBM in vivo but did not cause glomerulonephritis. In these mice, intact collagen IV from murine GBM was not immunogenic. However, in Col4a3−/− Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited IgG antibodies specific for α3α4α5NC1 hexamers, which were not subclass restricted. As heterologous antigen in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse IgG1, IgG2a and IgG2b autoAbs specific for α345NC1 hexamers and induced anti-GBM Ab glomerulonephritis. These findings indicate that tolerance toward autologous intact α3α4α5(IV) collagen is established in hosts expressing this antigen, even though autoreactive B cells specific for α345NC1 hexamers are not purged from their repertoire. Proteolysis selectively breaches this tolerance by generating autoimmunogenic α3α4α5NC1 hexamers. This provides a mechanism eliciting autoAbs specific for α345NC1 hexamers, which are restricted to non-inflammatory IgG subclasses and non-nephritogenic. In Alport syndrome, lack of tolerance toward α3α4α5(IV) collagen promotes production of alloantibodies to α345NC1 hexamers, including pro-inflammatory IgG subclasses which mediate post-transplant anti-GBM nephritis. PMID:23303673

  11. Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients.

    Science.gov (United States)

    McAdoo, Stephen P; Tanna, Anisha; Hrušková, Zdenka; Holm, Lisa; Weiner, Maria; Arulkumaran, Nishkantha; Kang, Amy; Satrapová, Veronika; Levy, Jeremy; Ohlsson, Sophie; Tesar, Vladimir; Segelmark, Mårten; Pusey, Charles D

    2017-09-01

    Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients with ANCA-associated vasculitis, 41 patients with anti-GBM disease, and 37 double-positive patients with ANCA and anti-GBM disease from four European centers. Double-positive patients shared characteristics of ANCA-associated vasculitis (AAV), such as older age distribution and longer symptom duration before diagnosis, and features of anti-GBM disease, such as severe renal disease and high frequency of lung hemorrhage at presentation. Despite having more evidence of chronic injury on renal biopsy compared to patients with anti-GBM disease, double-positive patients had a greater tendency to recover from being dialysis-dependent after treatment and had intermediate long-term renal survival compared to the single-positive patients. However, overall patient survival was similar in all three groups. Predictors of poor patient survival included advanced age, severe renal failure, and lung hemorrhage at presentation. No single-positive anti-GBM patients experienced disease relapse, whereas approximately half of surviving patients with AAV and double-positive patients had recurrent disease during a median follow-up of 4.8 years. Thus, double-positive patients have a truly hybrid disease phenotype, requiring aggressive early treatment for anti-GBM disease, and careful long-term follow-up and consideration for maintenance immunosuppression for AAV. Since double-positivity appears common, further work is required to define the underlying mechanisms of this association and define optimum treatment strategies. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  12. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

    Directory of Open Access Journals (Sweden)

    Nameeta Shah

    Full Text Available O⁶-methylguanine DNA-methyltransferase (MGMT promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of promoter methylation and its effect on gene silencing, and the patient's subsequent response to therapy, is still being defined. The aim of this study was to comprehensively characterize cytosine-guanine (CpG dinucleotide methylation across the entire MGMT promoter and to correlate individual CpG site methylation patterns to mRNA expression, protein expression, and progression-free survival. To best identify the specific MGMT promoter region most predictive of gene silencing and response to therapy, we determined the methylation status of all 97 CpG sites in the MGMT promoter in tumor samples from 70 GBM patients using quantitative bisulfite sequencing. We next identified the CpG site specific and regional methylation patterns most predictive of gene silencing and improved progression-free survival. Using this data, we propose a new classification scheme utilizing methylation data from across the entire promoter and show that an analysis based on this approach, which we call 3R classification, is predictive of progression-free survival (HR  = 5.23, 95% CI [2.089-13.097], p<0.0001. To adapt this approach to the clinical setting, we used a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA test based on the 3R classification and show that this test is both feasible in the clinical setting and predictive of progression free survival (HR  = 3.076, 95% CI [1.301-7.27], p = 0.007. We discuss the potential advantages of a test based on this promoter-wide analysis and compare it to the commonly used methylation-specific PCR test. Further prospective validation of these two methods in a large independent patient cohort will be needed to confirm the added value of promoter wide analysis of MGMT methylation in the clinical

  13. Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells.

    Science.gov (United States)

    Chou, Yu-Cheng; Chang, Meng-Ya; Wang, Mei-Jen; Liu, Hsin-Chung; Chang, Shu-Jen; Harnod, Tomor; Hung, Chih-Huang; Lee, Hsu-Tung; Shen, Chiung-Chyi; Chung, Jing-Gung

    2017-01-01

    Glioblastoma is the most common and aggressive primary brain malignancy. Phenethyl isothiocyanate (PEITC), a member of the isothiocyanate family, can induce apoptosis in many human cancer cells. Our previous study disclosed that PEITC induces apoptosis through the extrinsic pathway, dysfunction of mitochondria, reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress, and intrinsic (mitochondrial) pathway in human brain glioblastoma multiforme (GBM) 8401 cells. To the best of our knowledge, we first investigated the effects of PEITC on the genetic levels of GBM 8401 cells in vitro. PEITC may induce G0/G1 cell-cycle arrest through affecting the proteins such as cdk2, cyclin E, and p21 in GBM 8401 cells. Many genes associated with cell-cycle regulation of GBM 8401 cells were changed after PEITC treatment: 48 genes were upregulated and 118 were downregulated. The cell-division cycle protein 20 (CDC20), Budding uninhibited by benzimidazole 1 homolog beta (BUB1B), and cyclin B1 were downregulated, and clusterin was upregulated in GBM 8401 cells treated with PEITC. These changes of gene expression can provide the effects of PEITC on the genetic levels and potential biomarkers for glioblastoma. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 176-187, 2017.

  14. BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide.

    Science.gov (United States)

    Chen, Chien-Min; Syu, Jhih-Pu; Way, Tzong-Der; Huang, Li-Jiau; Kuo, Sheng-Chu; Lin, Chung-Tien; Lin, Chih-Li

    2015-11-01

    Glioblastoma multiforme (GBM) is the most fatal form of human brain cancer. Although temozolomide (TMZ), an oral alkylating chemotherapeutic agent, improves the survival rate, the prognosis of patients with GBM remains poor. Naturally occurring carbazole alkaloids isolated from curry leaves (Murraya koenigii Spreng.) have been shown to possess a wide range of anticancer properties. However, the effects of carbazole derivatives on glioblastoma cells remain poorly understood. In the present study, anti‑glioblastoma profiles of a series of synthetic carbazole derivatives were evaluated in vitro. The most promising derivative in this series was BC3EE2,9B, which showed significant anti‑proliferative effects in GBM8401 and GBM8901 cells. BC3EE2,9B also triggered cell‑cycle arrest, most prominently at the G1 stage, and suppressed glioblastoma cell invasion and migration. Furthermore, BC3EE2,9B induced autophagy‑mediated cell death and synergistically sensitized GBM cells to TMZ cytotoxicity. The possible mechanism underlying BC3EE2,9B‑induced autophagy may involve activation of adenosine monophosphate-activated protein kinase and the attenuation of the Akt and mammalian target of the rapamycin downstream signaling pathway. Taken together, the present results provide molecular evidence for the mode of action governing the ability of BC3EE2,9B to sensitize drug‑resistant glioblastoma cells to the chemotherapeutic agent TMZ.

  15. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Science.gov (United States)

    Bertagnolli, Nicolas M; Drake, Justin A; Tennessen, Jason M; Alter, Orly

    2013-01-01

    To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD) to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM) or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  16. Gravitational-wave Observations May Constrain Gamma-Ray Burst Models: The Case of GW150914-GBM

    Science.gov (United States)

    Veres, P.; Preece, R. D.; Goldstein, A.; Mészáros, P.; Burns, E.; Connaughton, V.

    2016-08-01

    The possible short gamma-ray burst (GRB) observed by Fermi/GBM in coincidence with the first gravitational-wave (GW) detection offers new ways to test GRB prompt emission models. GW observations provide previously inaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW 150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however, have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density (˜10-3 cm-3) and a high Lorentz factor (˜2000). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Blandford-Znajek model. If future joint observations confirm the GW-short-GRB association we can provide similar but more detailed tests for prompt emission models.

  17. THREE YEARS OF FERMI GBM EARTH OCCULTATION MONITORING: OBSERVATIONS OF HARD X-RAY/SOFT GAMMA-RAY SOURCES

    Energy Technology Data Exchange (ETDEWEB)

    Wilson-Hodge, Colleen A.; Jenke, Peter [ZP 12 Astrophysics Office, NASA Marshall Space Flight Center, Huntsville, AL 35812 (United States); Case, Gary L.; Cherry, Michael L.; Rodi, James [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803 (United States); Camero-Arranz, Ascension [Instituto de Ciencias del Espacio (IEEC-CSIC), Campus UAB, Torre C5, 2a planta, 08193 Barcelona (Spain); Chaplin, Vandiver; Bhat, Narayan; Briggs, Michael S.; Connaughton, Valerie; Preece, Robert [Physics Department, University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Beklen, Elif [Physics Department, Suleyman Demirel University, 32260 Isparta (Turkey); Finger, Mark; Paciesas, William S. [Universities Space Research Association, Huntsville, AL 35805 (United States); Greiner, Jochen; Meegan, Charles A.; Von Kienlin, Andreas [Max-Planck Institut fuer Extraterrestische Physik, D-85748 Garching (Germany); Kippen, R. Marc [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2012-08-01

    The Gamma-ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper, we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, and 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found online.

  18. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Jenke, P; Case, Gary L; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Chaplin, Vandiver; Beklen, Elif; Finger, Mark H; Bhat, Narayana; Briggs, Michael S; Connaughto, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2013-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi Gamma-ray Space Telescope has been providing continuous data to the astronomical community since 2008 August 12. We will present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. Although the occultation technique is in principle quite simple, in practice there are many complications including the dynamic instrument response, source confusion, and scattering in the Earth's atmosphere, which will be described. We detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to ot...

  19. Kepler K2 Observations of Sco X-1: Orbital Modulations and Correlations with Fermi GBM and MAXI

    CERN Document Server

    Hynes, R I; Baum, Z A; Hsu, C -C; Cherry, M L; Scaringi, S

    2016-01-01

    We present a multi-wavelength study of the low-mass X-ray binary Sco X-1 using Kepler K2 optical data and Fermi GBM and MAXI X-ray data. We recover a clear sinusoidal orbital modulation from the Kepler data. Optical fluxes are distributed bimodally around the mean orbital light curve, with both high and low states showing the same modulation. The high state is broadly consistent with the flaring branch of the Z diagram and the low state with the normal branch. We see both rapid optical flares and slower dips in the high state, and slow brightenings in the low state. High state flares exhibit a narrow range of amplitudes with a striking cut-off at a maximum amplitude. Optical fluxes correlate with X-ray fluxes in the high state, but in the low state they are anti-correlated. These patterns can be seen clearly in both flux-flux diagrams and cross-correlation functions and are consistent between MAXI and GBM. The high state correlation arises promptly with at most a few minutes lag. We attribute this to thermal ...

  20. First Results from Fermi GBM Earth Occultation Monitoring: Observations of Soft Gamma-Ray Sources Above 100 keV

    CERN Document Server

    Case, Gary L; Rodi, James C; Jenke, Peter; Wilson-Hodge, Colleen A; Finger, Mark H; Meegan, Charles A; Camero-Arranz, Ascencion; Beklen, Elif; Bhat, P Narayan; Briggs, Michael S; Chaplin, Vandiver; Connaughton, Valerie; Paciesas, William S; Preece, Robert; Kippen, R Marc; von Kienlin, Andreas; Griener, Jochen

    2010-01-01

    The NaI and BGO detectors on the Gamma-ray Burst Monitor (GBM) on Fermi are now being used for long-term monitoring of the hard X-ray/low energy gamma-ray sky. Using the Earth occultation technique as demonstrated previously by the BATSE instrument on the Compton Gamma-Ray Observatory, GBM can be used to produce multiband light curves and spectra for known sources and transient outbursts in the 8 keV to 1 MeV energy range with its NaI detectors and up to 40 MeV with its BGO detectors. Over 85% of the sky is viewed every orbit, and the precession of the Fermi orbit allows the entire sky to be viewed every ~26 days with sensitivity exceeding that of BATSE at energies below ~25 keV and above ~1.5 MeV. We briefly describe the technique and present preliminary results using the NaI detectors after the first two years of observations at energies above 100 keV. Eight sources are detected with a significance greater than 7 sigma: the Crab, Cyg X-1, SWIFT J1753.5-0127, 1E 1740-29, Cen A, GRS 1915+105, and the transien...

  1. Is surgical spinal decompression for supratentorial GBM symptomatic drop down metastasis warranted? A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Muhammad Babar Khan

    2014-01-01

    Full Text Available Background: Symptomatic spinal metastasis from an intracranial primary glioblastoma multiforme (GBM is very rare. Our literature search identified a total of 42 such patients of which 11 were treated with surgical decompression for spinal metastasis with only one such report from the pediatric age group. Previous studies have reported variable outcomes after surgical management. Case Description: We report the case of a 16-year-old boy who underwent surgical spinal decompression for spinal metastasis after intracranial GBM. The patient regained motor and autonomic function following surgery and reported improvement in pain. We also present findings from a literature review using the PubMed database from 1985 to June 2013 on this subject and compare radiation therapy with surgical decompression as palliative modalities in such patients. Conclusion: There are no evidence-based guidelines available on the subject and no treatment regimen has yet demonstrated survival benefit in these patients. Surgical decompression may be a better option for patients with focal resectable lesions and who are medically stable to tolerate the procedure.

  2. VizieR Online Data Catalog: IPN supplement to the 2nd Fermi GBM catalog (Hurley+, 2017)

    Science.gov (United States)

    Hurley, K.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Svinkin, D. S.; Pal'Shin, V. D.; Briggs, M. S.; Meegan, C.; Connaughton, V.; Goldsten, J.; Boynton, W.; Fellows, C.; Harshman, K.; Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B.; Rau, A.; von Kienlin, A.; Zhang, X.; Yamaoka, K.; Fukazawa, Y.; Ohno, M.; Tashiro, M.; Terada, Y.; Barthelmy, S.; Cline, T.; Gehrels, N.; Cummings, J.; Krimm, H. A.; Smith, D. M.; Del, Monte E.; Feroci, M.; Marisaldi, M.

    2017-06-01

    The triangulation technique utilized for the present catalog is identical to that used for the first IPN/GBM catalog; the details may be found in Hurley+ (2013, J/ApJS/207/39). Also, the missions and experiments comprising the InterPlanetary Network (IPN) are the same. The IPN consisted of Konus-Wind, at up to approximately 5light-seconds from Earth; Mars Odyssey, in orbit around Mars at up to 1250light-seconds from Earth; the International Gamma-Ray Laboratory (INTEGRAL), in an eccentric Earth orbit at up to 0.5light-seconds from Earth; Mercury Surface, Space Environment, Geochemistry, and Ranging mission (MESSENGER), in an eccentric orbit around Mercury beginning 2011 March 18, up to 690 light-seconds from Earth; and Ramaty High Energy Solar Spectroscopic Imager (RHESSI), Swift, Fermi, Suzaku, and AGILE, all in low-Earth orbit. (3 data files).

  3. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM

    Science.gov (United States)

    Crawford, Forrest W.; Khayal, Inas S.; McGue, Colleen; Saraswathy, Suja; Pirzkall, Andrea; Cha, Soonmee; Lamborn, Kathleen R.; Chang, Susan M.; Berger, Mitchel S.

    2010-01-01

    Glioblastoma Multiforme (GBM) are heterogeneous lesions, both in terms of their appearance on anatomic images and their response to therapy. The goal of this study was to evaluate the prognostic value of parameters derived from physiological and metabolic images of these lesions. Fifty-six patients with GBM were scanned immediately before surgical resection using conventional anatomical MR imaging and, where possible, perfusion-weighted imaging, diffusion-weighted imaging, and proton MR spectroscopic imaging. The median survival time was 517 days, with 15 patients censored. Absolute anatomic lesion volumes were not associated with survival but patients for whom the combined volume of contrast enhancement and necrosis was a large percentage of the T2 hyperintense lesion had relatively poor survival. Other volumetric parameters linked with less favorable survival were the volume of the region with elevated choline to N-acetylaspartate index (CNI) and the volume within the T2 lesion that had apparent diffusion coefficient (ADC) less than 1.5 times that in white matter. Intensity parameters associated with survival were the maximum and the sum of levels of lactate and of lipid within the CNI lesion, as well as the magnitude of the 10th percentile of the normalized ADC within the contrast-enhancing lesion. Patients whose imaging parameters indicating that lesions with a relatively large percentage with breakdown of the blood brain barrier or necrosis, large regions with abnormal metabolism or areas with restricted diffusion have relatively poor survival. These parameters may provide useful information for predicting outcome and for the stratification of patients into high or low risk groups for clinical trials. PMID:19009235

  4. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Directory of Open Access Journals (Sweden)

    Nicolas M Bertagnolli

    Full Text Available To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  5. The dosimetric impact of gadolinium-based contrast media in GBM brain patient plans for a MRI-Linac

    Science.gov (United States)

    Bilal Ahmad, Syed; Paudel, Moti Raj; Sarfehnia, Arman; Kim, Anthony; Pang, Geordi; Ruschin, Mark; Sahgal, Arjun; Keller, Brian M.

    2017-08-01

    Dosimetric effects of gadolinium based contrast media (Gadovist) were evaluated for the Elekta MRI linear accelerator using the research version of the Monaco treatment planning system (TPS). In order to represent a gadolinium uptake, the contrast was manually assigned to a phantom as well as to the gross tumour volume (GTV) of 6 glioblastoma multiforme (GBM) patients. A preliminary estimate of the dose enhancement, due to gadolinium, was performed using the phantom irradiated with a single beam. A more complicated assessment was performed for the GBM patients using a 7 field IMRT technique. The material table in Monaco was modified in order to identify the presence of a non-biological material. The dose distribution was modelled using GPUMCD (MC algorithm in Monaco) for an unmodified (or default) material table (DMT) as well as for a modified (or custom) material table (CMT) for both the phantom and patients. Various concentrations ranging between 8 and 157 mg ml-1 were used to represent the gadolinium uptake in the patient’s GTV. It was assumed that the gadolinium concentration remained the same for the entire course of radiation treatment. Results showed that at the tissue-Gadovist interface, inside the phantom, dose scored using the DMT was 7% lower compared to that using the CMT for 157 mg ml-1 concentration of gadolinium. Dosimetric differences in the case of the patient study were measured using the DVH parameters. D 50% was higher by 6% when the DMT was used compared to the CMT for dose modelling for a gadolinium concentration of 157 mg ml-1. This difference decreased gradually with decreasing concentration of gadolinium. It was concluded that dosimetric differences can be quantified in Monaco if the tumour-gadolinium concentration is more than 23 mg ml-1. If the gadolinium concentration is lower than 23 mg ml-1, then a correction for the presence of gadolinium may not be necessary in the TPS.

  6. Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.

    Directory of Open Access Journals (Sweden)

    Vikas Chandra

    Full Text Available Hedgehog (Hh signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM, a lethal malignancy of the central nervous system (CNS. By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we show here a strong correlation (r = 0.7 between GLI1 and PTCH1 mRNA expression--as a hallmark of the canonical Hh-pathway activity in this malignancy. GLI1 mRNA expression varied in 3 orders of magnitude among the GBM patients of the same cohort showing a single continuous distribution-unlike the discrete high/low-GLI1 mRNA expressing clusters of medulloblastoma (MB. When compared with MB as a reference, the median GLI1 mRNA expression in GBM appeared 14.8 fold lower than that of the "high-Hh" cluster of MB but 5.6 fold higher than that of the "low-Hh" cluster of MB. Next, we demonstrated statistically significant up- and down-regulation of GLI1 mRNA expressions in GBM patient-derived low-passage neurospheres in vitro by sonic hedgehog ligand-enriched conditioned media (shh-CM and by Hh-inhibitor drug vismodegib respectively. We also showed clinically achievable dose (50 μM of vismodegib alone to be sufficient to induce apoptosis and cell cycle arrest in these low-passage GBM neurospheres in vitro. Vismodegib showed an effect on the neurospheres, both by down-regulating GLI1 mRNA expression and by inducing apoptosis/cell cycle arrest, irrespective of their relative endogenous levels of GLI1 mRNA expression. We conclude from our study that this single continuous distribution pattern of GLI1 mRNA expression technically puts almost all GBM patients in a single group rather than discrete high- or low-clusters in terms of Hh-pathway activity. That is suggestive of therapies with Hh-pathway inhibitor drugs in this malignancy without a need for further stratification of patients on the basis of relative levels of Hh-pathway activity among them.

  7. TU-CD-BRB-04: Automated Radiomic Features Complement the Prognostic Value of VASARI in the TCGA-GBM Dataset

    Energy Technology Data Exchange (ETDEWEB)

    Velazquez, E Rios [Dana-Farber Cancer Institute | Harvard Medical School, Boston, MA (United States); Narayan, V [Dana-Farber Cancer Institute, Brigham and Womens Hospital, Harvard Medic, Boston, MA (United States); Grossmann, P [Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA (United States); Dunn, W; Gutman, D [Emory University School of Medicine, Atlanta, GA (United States); Aerts, H [Dana-Farber/Brigham Womens Cancer Center, Boston, MA (United States)

    2015-06-15

    Purpose: To compare the complementary prognostic value of automated Radiomic features to that of radiologist-annotated VASARI features in TCGA-GBM MRI dataset. Methods: For 96 GBM patients, pre-operative MRI images were obtained from The Cancer Imaging Archive. The abnormal tumor bulks were manually defined on post-contrast T1w images. The contrast-enhancing and necrotic regions were segmented using FAST. From these sub-volumes and the total abnormal tumor bulk, a set of Radiomic features quantifying phenotypic differences based on the tumor intensity, shape and texture, were extracted from the post-contrast T1w images. Minimum-redundancy-maximum-relevance (MRMR) was used to identify the most informative Radiomic, VASARI and combined Radiomic-VASARI features in 70% of the dataset (training-set). Multivariate Cox-proportional hazards models were evaluated in 30% of the dataset (validation-set) using the C-index for OS. A bootstrap procedure was used to assess significance while comparing the C-Indices of the different models. Results: Overall, the Radiomic features showed a moderate correlation with the radiologist-annotated VASARI features (r = −0.37 – 0.49); however that correlation was stronger for the Tumor Diameter and Proportion of Necrosis VASARI features (r = −0.71 – 0.69). After MRMR feature selection, the best-performing Radiomic, VASARI, and Radiomic-VASARI Cox-PH models showed a validation C-index of 0.56 (p = NS), 0.58 (p = NS) and 0.65 (p = 0.01), respectively. The combined Radiomic-VASARI model C-index was significantly higher than that obtained from either the Radiomic or VASARI model alone (p = <0.001). Conclusion: Quantitative volumetric and textural Radiomic features complement the qualitative and semi-quantitative annotated VASARI feature set. The prognostic value of informative qualitative VASARI features such as Eloquent Brain and Multifocality is increased with the addition of quantitative volumetric and textural features from the

  8. High affinity of anti-GBM antibodies from Goodpasture and transplanted Alport patients to alpha3(IV)NC1 collagen.

    Science.gov (United States)

    Rutgers, A; Meyers, K E; Canziani, G; Kalluri, R; Lin, J; Madaio, M P

    2000-07-01

    Anti-glomerular basement membrane (anti-GBM) antibody-mediated diseases are characterized by rapidly progressive glomerulonephritis (RPGN) that often results in irreversible loss of renal function and renal failure. Although many factors contribute to the fulminant nature and treatment resistance of this disease, we questioned whether high affinity autoantibody-alpha3(IV) collagen interactions lead to persistent antibody deposition, thereby perpetuating inflammation. To address this hypothesis, the binding kinetics of human anti-GBM antibodies (Ab) to alpha3(IV)NC1 were evaluated using an optical biosensor interaction analysis. Polyclonal anti-GBM Abs were purified by alpha3(IV)NC1 affinity chromatography from the sera of patients with anti-GBM AB-mediated diseases, including individuals with Goodpasture syndrome (GS), idiopathic RPGN (N = 7), and Alport syndrome (AL) following kidney transplantation (N = 4). The affinity-binding characteristics of the autoantibodies were determined using a biosensor analysis system, with immobilized bovine alpha3(IV)NC1 dimers. All of the autoantibody preparations bound to alpha3(IV)NC1, whereas none bound to alpha1(IV)NC1 (control). Purified, normal serum IgG did not bind to either antigen. Estimated dissociation constants (Kd) for the purified autoantibodies were 1.39E-04 +/- 7.30E-05 s-l (GS) and 8. 90E-05 +/- 2.80E-05 s-l (AL). Their estimated association constants (Ka) were 2.67E+04 +/- 1.8E+04 (M-ls-l) and 2.76E+04 +/- 1. 70E+04(M-ls-l) for GS and AL patients, respectively. By comparison with other Ab interactions, these Abs demonstrated high affinity, with relatively high on (binding) rates and slow off (dissociation) rates. The results suggest that anti-GBM Abs bind rapidly and remain tightly bound to the GBM in vivo. This property likely contributes to both the fulminant nature of this disease and its resistance to therapy, because persistent glomerular Ab deposition has the potential to produce continuous inflammation

  9. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress.

    Directory of Open Access Journals (Sweden)

    Yajuan Li

    Full Text Available Previously we have shown that kallikreins (klks play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs as vehicles to deliver klks into the injured kidneys and have measured their therapeutic effect on experimental antibody induced nephritis and lupus nephritis. Human KLK-1 (hKLK1 gene was transduced into murine MSCs using a retroviral vector to generate a stable cell line, hKLK1-MSC, expressing high levels of hKLK1. 129/svj mice subjected to anti-GBM induced nephritis were transplanted with 10(6 hKLK1-MSCs and hKLK1 expression was confirmed in the kidneys. Compared with vector-MSCs injected mice, the hKLK1-MSCs treated mice showed significantly reduced proteinuria, blood urea nitrogen (BUN and ameliorated renal pathology. Using the same strategy, we treated lupus-prone B6.Sle1.Sle3 bicongenic mice with hKLK1-MSCs and demonstrated that hKLK1-MSCs delivery also attenuated lupus nephritis. Mechanistically, hKLK1-MSCs reduced macrophage and T-lymphocyte infiltration into the kidney by suppressing the expression of inflammation cytokines. Moreover, hKLK1 transduced MSCs were more resistant to oxidative stress-induced apoptosis. These findings advance genetically modified MSCs as potential gene delivery tools for targeting therapeutic agents to the kidneys in order to modulate inflammation and oxidative stress in lupus nephritis.

  10. Fermi Guest Investigator Program Cycle 2 Project Final Report Albedo Polarimetry of Gamma-Ray Bursts and Solar Flares with GBM

    Energy Technology Data Exchange (ETDEWEB)

    Kippen, Richard Marc [Los Alamos National Laboratory

    2012-08-27

    Several key properties of GRBs remain poorly understood and are difficult or even impossible to infer with the information currently being collected. Polarization measurements will probe the precise nature of the central engine. For solar flares, high-energy polarization measurements are expected to be useful in determining the beaming (or directivity) of solar flare electrons - a quantity that may provide important clues about electron acceleration and transport. We propose to investigate the viability of using the Fermi Gamma-ray Burst Monitor (GBM) to measure the polarization of GRBs and solar flares using the albedo photon flux. This approach was previously developed for use with BATSE data. We will conduct a careful study of this technique using a modified version of the GRESS simulation tools developed by the GBM team.

  11. Earth Occultation Imaging Applied to BATSE -- Application to a Combined BATSE-GBM Survey of the Hard X-Ray Sky

    CERN Document Server

    Zhang, Yuan; Case, Gary; Ling, James; Wheaton, William

    2013-01-01

    A combined BATSE-GBM hard X-ray catalog is presented based on Earth Occultation Imaging applied to a reanalysis of BATSE data. An imaging approach has been developed for the reanalysis of Earth Occultation analysis of BATSE data. The standard occultation analysis depends on a predetermined catalog of potential sources, so that a real source not present in the catalog may induce systematic errors when source counts associated with an uncatalogued source are incorrectly attributed to catalog sources. The goal of the imaging analysis is to find a complete set of hard X-ray sources, including sources not in the original BATSE occultation catalog. Using the imaging technique, we have identified 15 known sources and 17 unidentified sources and added them to the BATSE occultation catalog. The resulting expanded BATSE catalog of sources observed during 1991-2000 is compared to the ongoing GBM survey.

  12. Epidermal growth factor receptor (EGFR mutation status and Rad51 determine the response of glioblastoma (GBM to multimodality therapy with cetuximab, temozolomide and radiation

    Directory of Open Access Journals (Sweden)

    Phyllis Rachelle Wachsberger

    2013-02-01

    Full Text Available Purpose: EGFR amplification and mutation (i.e., EGFRvIII are found in 40% of primary GBM tumors and are believed to contribute to tumor development and therapeutic resistance. This study was designed to investigate how EGFR mutational status modulates response to multimodality treatment with cetuximab, an anti-EGFR inhibitor, the chemotherapeutic agent, temozolamide (TMZ and radiation therapy (RT Methods and Materials: In vitro and in vivo experiments were performed on two isogenic U87 GBM cell lines: one overexpressing wildtype EGFR (U87wtEGFR and the other overexpressing EGFRvIII (U87EGFRvIII. Results: Xenografts harboring EGFRvIII were more sensitive to TMZ alone and TMZ in combination with RT and/or cetuximab than xenografts expressing wtEGFR. In vitro experiments demonstrated that U87EGFRvIII-expressing tumors appear to harbor defective DNA homologous recombination repair in the form of Rad51 processing, Conclusions: The difference in sensitivity between EGFR-expressing and EGFRvIII-expressing tumors to combined modality treatment may help in the future tailoring of GBM therapy to subsets of patients expressing more or less of the EGFR mutant.

  13. Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome

    Directory of Open Access Journals (Sweden)

    Kistler Thomas

    2011-06-01

    Full Text Available Abstract Background Pulmonary-renal syndrome associated with anti-glomerular basement membrane (GBM antibodies, also known as Goodpasture's syndrome, is a rare but acute and life-threatening condition. One third of patients presenting as anti-GBM antibody positive pulmonary-renal syndrome or rapidly progressive glomerulonephritis are also tested positive for anti-neutrophil cytoplasmic antibodies (ANCA. Whilst anti-GBM disease is considered a non-relapsing condition, the long-term course of double-positive patients is less predictable. Case Presentation We report a patient with such dual positivity, who presented with pulmonary hemorrhage, crescentic glomerulonephritis and membranous nephropathy. Plasmapheresis in combination with immunosuppresive therapy led to a rapid remission but the disease relapsed after two years. The serum of the patient was tested positive for antibodies to human lysosomal membrane protein 2 (hLAMP2, a novel autoantigen in patients with active small-vessel vasculitis (SVV. The anti-hLAMP2 antibody levels correlated positively with clinical disease activity in this patient. Conclusion We hypothesize that this antibody may indicate a clinical course similar to ANCA-associated vasculitis in double-positive patients. However, this needs to be confirmed on comprehensive patient cohorts.

  14. Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

    Directory of Open Access Journals (Sweden)

    Ravi D. Rao

    2005-10-01

    Full Text Available Elevated epidermal growth factor receptor (EGFR and mammalian target of rapamycin (mTOR signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM, which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target these protein kinases have been evaluated in multiple clinical trials for cancer patients, including those with GBM. Here we have examined the cellular and molecular effects of a combined kinase inhibition of mTOR (rapamycin and EGFR (EKI-785 in U87 and U251 GBM cells. Simultaneous treatment with rapamycin and EKI-785 results in synergistic antiproliferative as well as proapoptotic effects. At a molecular level, rapamycin alone significantly decreases S6 phosphorylation, whereas EKI-785 alone promotes substantially reduced signal transducer and activator of transcription (STAT3 phosphorylation. Treatment with rapamycin alone also increases Akt phosphorylation on Ser-473, but this effect is blocked by a simultaneous administration of EKI-785. Individually, EKI-785 diminishes while rapamycin promotes the binding of the translation inhibitor eukaryotic initiation factor 4E binding protein (4EBP1 to the eukaryotic translation initiation factor 4E (eIF4E. In spite of these opposing effects, the highest level of 4EBP1-eIF4E binding occurs with the combination of the two inhibitors. These results indicate that the inhibition of EGFR and mTOR has distinct as well as common signaling consequences and provides a molecular rationale forthe synergistic antitumor effects of EKI-785 and rapamycin administration.

  15. Sera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains.

    Science.gov (United States)

    Dehan, P; Weber, M; Zhang, X; Reeders, S T; Foidart, J M; Tryggvason, K

    1996-11-01

    Goodpasture (GP) syndrome is defined by the clinical association of pulmonary haemorrhage with rapidly progressive glomerulonephritis. The disease is caused by pathogenic autoantibodies directed against type IV collagen, which is a major structural component of glomerular basement membranes (GBM). The non-collagenous domains (NC1) of all six human type IV collagen alpha chains was produced in E. coli as recombinant fusion proteins with glutathione-S transferase. Sera from 10 patients with different types of anti-GBM nephritis, including GP syndrome, were tested for reactivity with the six proteins using immunoblotting of denatured and reduced proteins and ELISA without reduction. All 10 sera reacted with the alpha 3 (IV) collagen chain by immunoblotting and ELISA. One serum also recognized the alpha 2(IV), alpha 4(IV), alpha 5(IV) and alpha 6(IV) chains by immunoblotting. ELISA measurements revealed reactivity of several other sera with alpha 2(IV), alpha 4(IV) or alpha 6(IV) but not with alpha 5(IV) collagen chains. No reactivity was observed with the alpha 1(IV) chain. Autoantibodies in anti-GBM nephritis may not be directed only against the alpha 3(IV) collagen chain and they frequently recognize conformational epitopes.

  16. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.

    Directory of Open Access Journals (Sweden)

    Hikmat Assi

    Full Text Available Cellular microenvironments, particularly those found in tumors, elicit a tolerogenic DC phenotype which can attenuate immune responses. Central to this process is the STAT3-mediated signaling cascade. As a transcription factor and oncogene, STAT3 promotes the expression of genes which allow tumor cells to proliferate, migrate and evade apoptosis. More importantly, activation of STAT3 in tumor infiltrating immune cells has been shown to be responsible, in part, for their immune-suppressed phenotype. The ability of STAT3 to orchestrate a diverse set of immunosuppressive instructions has made it an attractive target for cancer vaccines. Using a conditional hematopoietic knockout mouse model of STAT3, we evaluated the impact of STAT3 gene ablation on the differentiation of dendritic cells from bone marrow precursors. We also assessed the impact of STAT3 deletion on phagocytosis, maturation, cytokine secretion and antigen presentation by GM-CSF derived DCs in vitro. In addition to in vitro studies, we compared the therapeutic efficacy of DC vaccination using STAT3 deficient DCs to wild type counterparts in an intracranial mouse model of GBM. Our results indicated the following pleiotropic functions of STAT3: hematopoietic cells which lacked STAT3 were unresponsive to Flt3L and failed to differentiate as DCs. In contrast, STAT3 was not required for GM-CSF induced DC differentiation as both wild type and STAT3 null bone marrow cells gave rise to similar number of DCs. STAT3 also appeared to regulate the response of GM-CSF derived DCs to CpG. STAT3 null DCs expressed high levels of MHC-II, secreted more IL-12p70, IL-10, and TNFα were better antigen presenters in vitro. Although STAT3 deficient DCs displayed an enhanced activated phenotype in culture, they elicited comparable therapeutic efficacy in vivo compared to their wild type counterparts when utilized in vaccination paradigms in mice bearing intracranial glioma tumors.

  17. Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — Fermi is a powerful space observatory that will open a wide window on the universe. Gamma rays are the highest-energy form of light, and the gamma-ray sky is...

  18. Maine's Employability Skills Program

    Science.gov (United States)

    McMahon, John M.; Wolffe, Karen E.; Wolfe, Judy; Brooker, Carrie

    2013-01-01

    This Practice Report describes the development and implementation of the "Maine Employability Skills Program," a model employment program developed by the Maine Division for the Blind and Visually Impaired (DBVI). The program was designed to support the efforts of the chronically unemployed or underemployed. These consumers were either…

  19. Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells1

    Science.gov (United States)

    Rao, Ravi D; Mladek, Ann C; Lamont, Jeffrey D; Goble, Jennie M; Erlichman, Charles; James, C David; Sarkaria, Jann N

    2005-01-01

    Abstract Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM), which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target these protein kinases have been evaluated in multiple clinical trials for cancer patients, including those with GBM. Here we have examined the cellular and molecular effects of a combined kinase inhibition of mTOR (rapamycin) and EGFR (EKI-785) in U87 and U251 GBM cells. Simultaneous treatment with rapamycin and EKI-785 results in synergistic antiproliferative as well as proapoptotic effects. At a molecular level, rapamycin alone significantly decreases S6 phosphorylation, whereas EKI-785 alone promotes substantially reduced signal transducer and activator of transcription (STAT3) phosphorylation. Treatment with rapamycin alone also increases Akt phosphorylation on Ser-473, but this effect is blocked by a simultaneous administration of EKI-785. Individually, EKI-785 diminishes while rapamycin promotes the binding of the translation inhibitor eukaryotic initiation factor 4E binding protein (4EBP1) to the eukaryotic translation initiation factor 4E (eIF4E). In spite of these opposing effects, the highest level of 4EBP1-eIF4E binding occurs with the combination of the two inhibitors. These results indicate that the inhibition of EGFR and mTOR has distinct as well as common signaling consequences and provides a molecular rationale for the synergistic antitumor effects of EKI-785 and rapamycin administration. PMID:16242075

  20. Turbine main engines

    CERN Document Server

    Main, John B; Herbert, C W; Bennett, A J S

    1965-01-01

    Turbine Main Engines deals with the principle of operation of turbine main engines. Topics covered include practical considerations that affect turbine design and efficiency; steam turbine rotors, blades, nozzles, and diaphragms; lubricating oil systems; and gas turbines for use with nuclear reactors. Gas turbines for naval boost propulsion, merchant ship propulsion, and naval main propulsion are also considered. This book is divided into three parts and begins with an overview of the basic mode of operation of the steam turbine engine and how it converts the pressure energy of the ingoing ste

  1. Maine Field Station

    Data.gov (United States)

    Federal Laboratory Consortium — In 2000 NOAA's National Marine Fisheries Service established the Maine Field Station in Orono, ME to have more direct involvement in the conservation of the living...

  2. 2004 Maine Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This metadata document describes the collection and processing of Light Detection and Ranging (LIDAR) data over an area along the coast of Maine. Data was collected...

  3. Study of luminosity and spin-up relation in X-ray binary pulsars with long-term monitoring by MAXI/GSC and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Nakajima, Motoki; Yamaoka, Kazutaka

    2015-01-01

    We study the relation between luminosity and spin-period change in X-ray binary pulsars using long-term light curve obtained by the MAXI/GSC all-sky survey and pulse period data from the Fermi/GBM pulsar project. X-ray binaries, consisting of a highly magnetized neutron star and a stellar companion, originate X-ray emission according to the energy of the accretion matter onto the neutron star. The accretion matter also transfers the angular momentum at the Alfven radius, and then spin up the neutron star. Therefore, the X-ray luminosity and the spin-up rate are supposed to be well correlated. We analyzed the luminosity and period-change relation using the data taken by continuous monitoring of MAXI/GSC and Fermi/GBM for Be/X-ray binaries, GX 304$-$1, A 0535$+$26, GRO J1008$-$57, KS 1947$+$300, and 2S 1417$-$624, which occurred large outbursts in the last four years. We discuss the results comparing the obtained observed relation with that of the theoretical model by Ghosh \\& Lamb (1979).

  4. The main cubioid

    Science.gov (United States)

    Blokh, Alexander; Oversteegen, Lex; Ptacek, Ross; Timorin, Vladlen

    2014-08-01

    The connectedness locus in the parameter space of quadratic polynomials is called the Mandelbrot set. A good combinatorial model of this set is due to Thurston. By definition, the principal hyperbolic domain of the Mandelbrot set consists of parameter values, for which the corresponding quadratic polynomials have an attracting fixed point. The closure of the principal hyperbolic domain of the Mandelbrot set is called the main cardioid. Its topology is completely described by Thurston's model. Less is known about the connectedness locus in the parameter space of cubic polynomials. In this paper, we discuss cubic analogues of the main cardioid and establish relationships between them.

  5. Ladybugs of Maine

    Science.gov (United States)

    Color images are presented for the 57 species of Coccinellidae, commonly known as ladybugs, that are documented from Maine. Images are displayed in taxonomic order. Information on each species includes its genus-species name, length, and an actual-size silhouette beside a grid matched to the scale...

  6. Abstracts of Main Essays

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    On Engels'Dialectics of "Theoretical Thinking" Sun Zheng-yu The main significant contribution to Marxist dialectics of Engels is to formulate dialectics on the level of theoretical thinking. This contribution is expressed in three aspects: 1 ) generalizing thoroughly the historical evolution of the way of thinking embodied in science history, philosophy history and human history;

  7. Renovating the Main Building

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    CERN's "Main Building" is exactly that. The Organization's central hub, with hundreds of staff and visitors passing through its doors every day, will soon be getting a well-earned facelift. Refurbishment work will proceed in phases, starting with the Salle des Pas Perdus, the concourse between the Council Chamber and the Main Auditorium. By the end of August, informal seating areas will be installed, electronic display panels will provide practical information and improved sound insulation will enhance conditions in the auditoria and surrounding meeting rooms.   In light green the area that will undergo the facelift. Work will start in July. The ground floor is home to the entrance to Restaurant No. 1, the bank, the post office, the travel agent, the Users Office, the Staff Association, the notice boards etc. Step up to the first floor to access CERN's largest lecture theatre, the Council Chamber and its "Pas Perdus" lobby. Everyone who works at or visits CERN i...

  8. Maine coast winds

    Energy Technology Data Exchange (ETDEWEB)

    Avery, Richard

    2000-01-28

    The Maine Coast Winds Project was proposed for four possible turbine locations. Significant progress has been made at the prime location, with a lease-power purchase contract for ten years for the installation of turbine equipment having been obtained. Most of the site planning and permitting have been completed. It is expect that the turbine will be installed in early May. The other three locations are less suitable for the project, and new locations are being considered.

  9. Lodging Update: Portland, Maine

    Directory of Open Access Journals (Sweden)

    Rachel J. Roginsky

    2013-01-01

    Full Text Available Each quarter, Pinnacle Advisory Group prepares an analysis of the New England lodging industry, which provides a regional summary and then focuses in depth on a particular market. These reviews look at recent and proposed supply changes, factors affecting demand and growth rates, and the effects of interactions between such supply and demand trends. In this issue, the authors summarize regional performance for 2012, offer projections for 2013, and spotlight the lodging market in Portland, Maine.

  10. Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

    Directory of Open Access Journals (Sweden)

    Garcia Juan L

    2010-08-01

    Full Text Available Abstract Background Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. Even in those patients with low-grade gliomas, that imply a moderately good prognosis, treatment is almost never curative. Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow in vitro forming neurospheres and that can be isolated in vivo using surface markers such as CD133. The aim of this study was to define the molecular signature of GBM cells expressing CD133 in comparison with non expressing CD133 cells. This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM. Methods Eight fresh, primary and non cultured GBMs were used in order to study the gene expression signatures from its CD133 positive and negative populations isolated by FACS-sorting. Dataset was generated with Affymetrix U133 Plus 2 arrays and analysed using the software of the Affymetrix Expression Console. In addition, genomic analysis of these tumours was carried out by CGH arrays, FISH studies and MLPA; Results Gene expression analysis of CD133+ vs. CD133- cell population from each tumour showed that CD133+ cells presented common characteristics in all glioblastoma samples (up-regulation of genes involved in angiogenesis, permeability and down-regulation of genes implicated in cell assembly, neural cell organization and neurological disorders. Furthermore, unsupervised clustering of gene expression led us to distinguish between two groups

  11. Main Oxidizer Valve Design

    Science.gov (United States)

    Addona, Brad; Eddleman, David

    2015-01-01

    A developmental Main Oxidizer Valve (MOV) was designed by NASA-MSFC using additive manufacturing processes. The MOV is a pneumatically actuated poppet valve to control the flow of liquid oxygen to an engine's injector. A compression spring is used to return the valve to the closed state when pneumatic pressure is removed from the valve. The valve internal parts are cylindrical in shape, which lends itself to traditional lathe and milling operations. However, the valve body represents a complicated shape and contains the majority of the mass of the valve. Additive manufacturing techniques were used to produce a part that optimized mass and allowed for design features not practical with traditional machining processes.

  12. Abstracts of Main Essays

    Institute of Scientific and Technical Information of China (English)

    Feng Zi-yi

    2011-01-01

    On Deepening the Research on the Law of the Social Horizontal Development Feng Zi-yi The further development of globalization makes it urgent to deepen the research on the law of social hori- zontal development. Historical development of human society has experienced periods of isolation, multi-cen- ter, and globalization, while the truly horizontal development began from modernity. This kind of development is driven mainly by the logic of capital. The transforming process of capital, from dominating the whole process of economic development toward all aspects of social life, and from dominating nations toward the whole world, is also the logical process of capital pursuing itself and the process of social horizontal and wholly development as well. Horizontal and vertical developments of the society are interacting always. Researching on the law of social horizontal development is important for us to adapt to the historical trend consciously, to grasp the logic of capital rationally and to choose the right road of development.

  13. Lamb shift of Unruh detector levels

    Energy Technology Data Exchange (ETDEWEB)

    Garbrecht, Bjoern [School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); Prokopec, Tomislav [Institute for Theoretical Physics (ITF) and Spinoza Institute, Utrecht University, Leuvenlaan 4, Postbus 80.195, 3508 TD Utrecht (Netherlands)

    2006-06-07

    We argue that the energy levels of an Unruh detector experience an effect similar to the Lamb shift in quantum electrodynamics. As a consequence, the spectrum of energy levels in a curved background is different from that in flat space. As examples, we consider a detector in an expanding universe and in Rindler space, and for the latter case we suggest a new expression for the local virtual energy density seen by an accelerated observer. In the ultraviolet domain, that is when the space between the energy levels is larger than the Hubble rate or the acceleration of the detector, the Lamb shift quantitatively dominates over the thermal response rate.

  14. Lamb Shift of Unruh Detector Levels

    CERN Document Server

    Garbrecht, B; Garbrecht, Bjorn; Prokopec, Tomislav

    2006-01-01

    We argue that the energy levels of an Unruh detector experience an effect similar to the Lamb shift in Quantum Electrodynamics. As a consequence, the spectrum of energy levels in a curved background is different from that in flat space. As examples, we consider a detector in an expanding Universe and in Rindler space, and for the latter case we suggest a new expression for the local virtual energy density seen by an accelerated observer. In the ultraviolet domain, that is when the space between the energy levels is larger than the Hubble rate or the acceleration of the detector, the Lamb shift quantitatively dominates over the thermal response rate.

  15. SU-D-BRB-06: Treating Glioblastoma Multiforme (GBM) as a Chronic Disease: Implication of Temporal-Spatial Dose Fractionation Optimization Including Cancer Stem Cell Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Pajonk, F; Kaprealian, T; Kupelian, P; Steinberg, M; Low, D; Sheng, K [Department of Radiation Oncology, UCLA, Los Angeles, CA (United States)

    2015-06-15

    Purpose: To explore the feasibility of improving GBM treatment outcome with temporal-spatial dose optimization of an ordinary differential equation (ODE) that models the differentiation and distinct radiosensitivity between cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The ODE was formulated into a non-convex optimization problem with the objective to minimize remaining total cancer cells 500 days from the onset of radiotherapy when the total cancer cell number was 3.5×10{sup 7}, while maintaining normal tissue biological effective dose (BED) of 100Gy resulted from standard prescription of 2Gyx30. Assuming spatially separated CSC and DCC, optimization was also performed to explore the potential benefit from dose-painting the two compartments. Dose escalation to a sub-cell-population in the GTV was also examined assuming that a 2 cm margin around the GTV allows sufficient dose drop-off to 100Gy BED. The recurrence time was determined as the time at which the total cancer cell number regrows to 10{sup 9} cells. Results: The recurrence time with variable fractional doses administered once per week, bi-week and month for one year were found to be 615, 593 and 570 days, superior to the standard-prescription recurrence time of 418 days. The optimal dose-fraction size progression for both uniform and dose-painting to the tumor is low and relatively constant in the beginning and gradually increases to more aggressive fractions at end of the treatment course. Dose escalation to BED of 200Gy to the whole tumor alongside with protracted weekly treatment was found to further delay recurrence to 733 days. Dose-painting of 200 and 500Gy BED to CSC on a year-long weekly schedule further extended recurrence to 736 and 1076 days, respectively. Conclusion: GBM treatment outcome can possibly be improved with a chronic treatment approach. Further dose escalation to the entire tumor or CSC targeted killing is needed to achieve total tumor control. This work

  16. Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.

    Science.gov (United States)

    Liao, Chia-Leng; Chen, Chien-Min; Chang, Yan-Zin; Liu, Guang-Yaw; Hung, Hui-Chih; Hsieh, Tung-Ying; Lin, Chih-Li

    2014-10-29

    Pine needle extracts of Pinus morrisonicola (Hayata) are commonly used as a functional health beverage. However, it remains unclear what the mechanism is underlying the antitumor activity of pine needle extract. The aims of present study were to investigate the anti-glioblastoma effects of pine needle extracts as well as its bioactive compounds. From three different solvent extracts of pine needles, the water extract displayed the strongest cytotoxicity effects on GBM8901 glioblastoma cells. The isolated compounds were identified as pinocembrin, chrysin, and tiliroside. Chrysin was the most active ingredient of pine needle extract for the induction of apoptosis and suppression of migration and invasion. It also markedly inhibited temozolomide (TMZ)-induced autophagy and O(6)-methylguanine-DNA methyltransferase (MGMT) expression. Because both autophagy and MGMT overexpression have been implicated to TMZ-induced drug resistance in glioblastoma, our results showed that pine needle extract and chrysin may serve as a potential anticancer agent against glioblastoma, especially with regard to sensitizing glioblastoma cells resistant to TMZ.

  17. Superior GVHD-free, relapse-free survival for G-BM to G-PBSC grafts is associated with higher MDSCs content in allografting for patients with acute leukemia.

    Science.gov (United States)

    Fan, Qian; Liu, Hui; Liang, Xinquan; Yang, Ting; Fan, Zhiping; Huang, Fen; Ling, Yiwen; Liao, Xin; Xuan, Li; Xu, Na; Xu, Xiaojun; Ye, Jieyu; Liu, Qifa

    2017-07-04

    Granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cells (G-PBSC) has largely replaced unstimulated bone marrow (un-BM) for allografting because of accelerated engraftment, but with a higher morbidity and mortality of graft-versus-host-disease (GVHD). Recent studies suggested that G-CSF-primed BM (G-BM) had similar engraftment but lower morbidity and mortality of GVHD comparing to G-PBSC. A prospective, randomized, multicenter study was conducted to compare G-BM with G-PBSC as the grafts in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute leukemia in first complete remission (CR1). Totally 101 adult leukemia in CR1 undergoing HLA-identical sibling transplants were randomized into G-BM or G-PBSC group. The primary study endpoint was GVHD-free/relapse-free survival (GRFS). Both the engraftment of neutrophil and platelet were 2 days later in G-BM than in G-PBSC group (P = 0.412, P = 0.39). G-BM group showed significantly lower II-IV acute GVHD (aGVHD) and similar III-IV aGVHD compared with G-PBSC group (12.2% vs 28.8% for II-IV, P = 0.048; 4.1% vs 9.6% for III-IV aGVHD, P = 0.267, respectively). The overall cumulative incidence of chronic GVHD (cGVHD) at 3 years were 22.3% ± 6.3% and 44.8% ± 7.6% (P = 0.026), respectively, and extensive cGHVD were 4.5% ± 3.1% and 15% ± 5.3% (P = 0.08), respectively, in G-BM and G-PBSC groups. Two groups had similar 3-year relapse, transplant-related mortality (TRM), overall survival (OS), and disease-free survival (DFS) (all P > 0.05). G-BM group showed significantly higher probability of GRFS than G-PBSC group (73.5% ± 6.3% vs 55.8% ± 6.9% at 1 year, P = 0.049; 69.0% ± 6.7% vs 49.7% ± 7.0% at 2 and 3 years, P = 0.03, respectively). Graft content analysis revealed statistically higher frequency of myeloid-derived suppressor cells (MDSCs) in the G-BM than in G-PBSC grafts (P G-BM than in G-PBSC group (P

  18. PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rho A, and Ras with inhibition of MMP-2, -7 and -9 gene expression.

    Science.gov (United States)

    Chou, Yu-Cheng; Chang, Meng-Ya; Wang, Mei-Jen; Yu, Fu-Shun; Liu, Hsin-Chung; Harnod, Tomor; Hung, Chih-Huang; Lee, Hsu-Tung; Chung, Jing-Gung

    2015-11-01

    Glioblastoma is the most aggressive primary brain malignancy, and the efficacy of multimodality treatments remains unsatisfactory. Phenethyl isothiocyanate (PEITC), one member of the isothiocyanate family, was found to inhibit the migration and invasion of many types of human cancer cells. In our previous study, PEITC induced the apoptosis of human brain glioblastoma GBM 8401 cells through the extrinsic and intrinsic signaling pathways. In the present study, we first investigated the effects of PEITC on the migration and invasion of GBM 8401 cells. PEITC decreased the migration of GBM 8401 cells in a dose-dependent manner as determined from scratch wound healing and Transwell migration assays. The percentage of inhibition ranged from 46.89 to 15.75%, and from 27.80 to 7.31% after a 48-h treatment of PEITC as determined from the Transwell migration assay and invasion assay, respectively. The western blot analysis indicated that PEITC decreased the levels of proteins associated with migration and invasion, Ras, uPA, RhoA, GRB2, p-p38, p-JNK, p-ERK, p65, SOS1, MMP-2, MMP-9 and MMP-13, in a dose-dependent manner. Real-time PCR analyses revealed that PEITC reduced the mRNA levels of MMP-2, MMP-7, MMP-9 and RhoA in a dose- and time-dependent manner. PEITC exhibited potent anticancer activities through the inhibition of migration and invasion in the GBM 8401 cells. Our findings elucidate the possible molecular mechanisms and signaling pathways of the anti-metastatic effects of PEITC on human brain glioblastoma cells, and PEITC may be considered as a therapeutic agent.

  19. Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?

    Directory of Open Access Journals (Sweden)

    Stefaan W. van Gool

    2013-08-01

    Full Text Available Despite recent advances in tumor imaging and chemoradiotherapy, the median overall survival of patients diagnosed with glioblastoma multiforme does not exceed 15 months. Infiltration of glioma cells into the brain parenchyma, and the blood-brain barrier are important hurdles to further increase the efficacy of classic therapeutic tools. Local administration methods of therapeutic agents, such as convection enhanced delivery and intracerebral injections, are often associated with adverse events. The intranasal pathway has been proposed as a non-invasive alternative route to deliver therapeutics to the brain. This route will bypass the blood-brain barrier and limit systemic side effects. Upon presentation at the nasal cavity, pharmacological agents reach the brain via the olfactory and trigeminal nerves. Recently, formulations have been developed to further enhance this nose-to-brain transport, mainly with the use of nanoparticles. In this review, the focus will be on formulations of pharmacological agents, which increase the nasal permeation of hydrophilic agents to the brain, improve delivery at a constant and slow release rate, protect therapeutics from degradation along the pathway, increase mucoadhesion, and facilitate overall nasal transport. A mounting body of evidence is accumulating that the underexplored intranasal delivery route might represent a major breakthrough to combat glioblastoma.

  20. The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival.

    Directory of Open Access Journals (Sweden)

    Janice A Royds

    Full Text Available Prognostic markers for glioblastoma multiforme (GBM are important for patient management. Recent advances have identified prognostic markers for GBMs that use telomerase or the alternative lengthening of telomeres (ALT mechanism for telomere maintenance. Approximately 40% of GBMs have no defined telomere maintenance mechanism (NDTMM, with a mixed survival for affected individuals. This study examined genetic variants in the cyclin-dependent kinase inhibitor 2A (CDKN2A gene that encodes the p16(INK4a and p14(ARF tumor suppressors, and the isocitrate dehydrogenase 1 (IDH1 gene as potential markers of survival for 40 individuals with NDTMM GBMs (telomerase negative and ALT negative by standard assays, 50 individuals with telomerase, and 17 individuals with ALT positive tumors. The analysis of CDKN2A showed NDTMM GBMs had an increased minor allele frequency for the C500G (rs11515 polymorphism compared to those with telomerase and ALT positive GBMs (p = 0.002. Patients with the G500 allele had reduced survival that was independent of age, extent of surgery, and treatment. In the NDTMM group G500 allele carriers had increased loss of CDKN2A gene dosage compared to C500 homozygotes. An analysis of IDH1 mutations showed the R132H mutation was associated with ALT positive tumors, and was largely absent in NDTMM and telomerase positive tumors. In the ALT positive tumors cohort, IDH1 mutations were associated with a younger age for the affected individual. In conclusion, the G500 CDKN2A allele was associated with NDTMM GBMs from older individuals with poorer survival. Mutations in IDH1 were not associated with NDTMM GBMs, and instead were a marker for ALT positive tumors in younger individuals.

  1. Maine Agricultural Foods. Project SEED.

    Science.gov (United States)

    Beaulieu, Peter; Ossenfort, Pat

    This paper describes an activity-based program that teaches students in grades 4-12 about the importance of Maine agriculture in their lives. Specifically, the goal is to increase student awareness of how the foods they eat are planted, harvested, and processed. The emphasis is on crops grown in Maine such as potatoes, broccoli, peas, blueberries,…

  2. The American Eider in Maine

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The American eider, Maine's only breeding sea duck, is known to have nested on 215 coastal islands of the State in 1976. In Maine, eiders seem to prefer to nest on...

  3. Main Propulsion Test Article (MPTA)

    Science.gov (United States)

    Snoddy, Cynthia

    2010-01-01

    Scope: The Main Propulsion Test Article integrated the main propulsion subsystem with the clustered Space Shuttle Main Engines, the External Tank and associated GSE. The test program consisted of cryogenic tanking tests and short- and long duration static firings including gimbaling and throttling. The test program was conducted on the S1-C test stand (Position B-2) at the National Space Technology Laboratories (NSTL)/Stennis Space Center. 3 tanking tests and 20 hot fire tests conducted between December 21 1 1977 and December 17, 1980 Configuration: The main propulsion test article consisted of the three space shuttle main engines, flightweight external tank, flightweight aft fuselage, interface section and a boilerplate mid/fwd fuselage truss structure.

  4. Impacts of climate change and socio-economic scenarios on flow and water quality of the Ganges, Brahmaputra and Meghna (GBM) river systems: low flow and flood statistics.

    Science.gov (United States)

    Whitehead, P G; Barbour, E; Futter, M N; Sarkar, S; Rodda, H; Caesar, J; Butterfield, D; Jin, L; Sinha, R; Nicholls, R; Salehin, M

    2015-06-01

    The potential impacts of climate change and socio-economic change on flow and water quality in rivers worldwide is a key area of interest. The Ganges-Brahmaputra-Meghna (GBM) is one of the largest river basins in the world serving a population of over 650 million, and is of vital concern to India and Bangladesh as it provides fresh water for people, agriculture, industry, conservation and for the delta system downstream. This paper seeks to assess future changes in flow and water quality utilising a modelling approach as a means of assessment in a very complex system. The INCA-N model has been applied to the Ganges, Brahmaputra and Meghna river systems to simulate flow and water quality along the rivers under a range of future climate conditions. Three model realisations of the Met Office Hadley Centre global and regional climate models were selected from 17 perturbed model runs to evaluate a range of potential futures in climate. In addition, the models have also been evaluated using socio-economic scenarios, comprising (1) a business as usual future, (2) a more sustainable future, and (3) a less sustainable future. Model results for the 2050s and the 2090s indicate a significant increase in monsoon flows under the future climates, with enhanced flood potential. Low flows are predicted to fall with extended drought periods, which could have impacts on water and sediment supply, irrigated agriculture and saline intrusion. In contrast, the socio-economic changes had relatively little impact on flows, except under the low flow regimes where increased irrigation could further reduce water availability. However, should large scale water transfers upstream of Bangladesh be constructed, these have the potential to reduce flows and divert water away from the delta region depending on the volume and timing of the transfers. This could have significant implications for the delta in terms of saline intrusion, water supply, agriculture and maintaining crucial ecosystems such

  5. Gulf of Maine intermediate water

    Energy Technology Data Exchange (ETDEWEB)

    Hopkins, T.S. (Brookhaven National Lab., Upton, NY); Garfield, N. III

    1979-01-01

    The thermohaline dynamics of the Gulf of Maine are analyzed from the two year, eight cruise, data set of Colton, Marak, Nickerson, and Stoddard (1968). Six water masses are described: the Maine Surface Water, Maine Intermediate Water, and the Maine Bottom Water as interior water masses; and the Scotian Shelf Water, the Slope Water, and the Georges Bank Water as exterior water masses. Particular attention is given to the formation and disposition of the Maine Intermediate Water. Salt balance, T-S volume, and T-S drift analyses are used to provide transport and mixing estimates for the year 1966. The Slope Water entered at depth through the Northeast Channel at a rate of 2600 km/sup 3//yr; while the Scotian Shelf Water entered the surface and intermediate layers, mostly during winter intrusions, at a rate of 5200 km/sup 3//yr. The surface and intermediate layers exported a total of 7900 km/sup 3//yr in a 3:5 ratio, respectively. The Maine Intermediate Water tends to collect over the Wilkinson Basin during the stratified season, to exit via the Great South Channel during early spring, and to exit via the Northeast Channel during spring and summer. Comparisons are made between the estimated winter heat loss of 280 Ly/d and the observed heat losses of 230 Ly/d (surface layers) and 360 Ly/d (surface and intermediate layers). A limit for the Scotian Shelf Water contribution is about -70 Ly/d. It is concluded that the Maine Intermediate Water is produced locally and that it is exported in significant quantities.

  6. Non-main Stream Plays Main Role in Shipbuilding Market

    Institute of Scientific and Technical Information of China (English)

    Qin Ping

    2009-01-01

    @@ Comparing with both the major shipyards and shipping companies that were facing an market decline and hard time,the non-mainstream ship types,non-mainstream ship manufacturers and non-mainstream ship owners,as main roles,made a wonderful show of living and developing in 2009.

  7. Architectural Portfolio 2001: Main Winners.

    Science.gov (United States)

    American School & University, 2001

    2001-01-01

    Presents descriptions and photographs of the following two American School and University Architectural Portfolio main winners for 2001: Chesterton, Indiana's Chesterton High School and Lied Library at the University of Nevada, Las Vegas. Included are each project's vital statistics, the architectural firm involved, and a list of designers.(GR)

  8. The four main LHC experiments

    CERN Multimedia

    AC Team

    1999-01-01

    This diagram shows the locations of the four main experiments (ALICE, ATLAS, CMS and LHCb) that will take place at the LHC. Located between 50 m and 150 m underground, huge caverns have been excavated to house the giant detectors. The SPS, the final link in the pre-acceleration chain, and its connection tunnels to the LHC are also shown.

  9. High-energy emission from bright gamma-ray bursts using Fermi

    Energy Technology Data Exchange (ETDEWEB)

    Bissaldi, Elisabetta

    2010-05-25

    mainly based on the brightest bursts detected by GBM inside the LAT field-of-view. The determination of a consistent sample for upper-limit calculations can be established by selecting those bursts which have a strong signal in the GBM BGO detectors. The structure of this thesis can be summarized as follows: The first chapter introduces the basic concepts and scientific background of GRB physics. Afterwards, instrumental details about the Fermi instruments LAT and GBM, as well as LAT performance and capabilities for GRB science are presented in chapter 2. Chapter 3 focuses on the detector-level calibration of the GBM instrument, and in particular on the analysis methods and results, which crucially support the development of a consistent GBM instrument response. The main GBM scientific results collected during the first year of operation are then presented in chapter 4. Particular emphasis is given to the description of joint GBM-LAT and GBM-Swift observations and analysis results. The last chapter presents the selection methodology and detailed spectral analysis of a sample of well-defined BGO-bright bursts detected by GBM during its first year. Using these results, correlations among spectral parameters are finally discussed. (orig.)

  10. Luminosity and spin-period evolution of GX 304$-$1 during outbursts from 2009 to 2013 observed with the MAXI/GSC, RXTE/PCA, and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Mihara, Tatehiro; Nakajima, Motoki; Makishima, Kazuo

    2015-01-01

    A report is made on the luminosity and pulse-period evolution of the Be binary X-ray pulsar, GX 304$-$1, during a series of outbursts from 2009 to 2013 observed by MAXI/GSC, RXTE/PCA, and Fermi/GBM. In total, twelve outbursts repeated by $\\sim$ 132.2 days were observed, which is consistent with the X-ray periodicity of this object observed in the 1970s. These 12 outbursts, together with those in the 1970s, were found to all recur with a well defined period of 132.189$\\pm$0.02 d, which can be identified with the orbital period. The pulse period at $\\sim 275$ s, obtained from the RXTE/PCA and Fermi/GBM data, apparently exhibited a periodic modulation synchronized with the outburst period, suggesting the pulsar orbital motion, which is superposed on a secular spin-up trend throughout the entire active phase. The observed pulse-period changes were successfully represented by a model composed of the binary orbital modulation and pulsar spin up caused by mass accretion through an accretion disk. The orbital element...

  11. Main Elements for Upscaling Recreation

    DEFF Research Database (Denmark)

    Zandersen, Marianne; Termansen, Mette

    2012-01-01

    This report provides information on the main elements used to scale up modelled local visitor flow data to regional level based on recreational de-mand models. These models are described in Report #1. This report also provides information on data sources such as spatial data (e.g. land cov......-er/land use information), demographic information. The report is accom-pagnied with a spatial database for the regional case of forest recreation in Northern Zealand, Denmark. The spatial database contains forest polygons; forest attribute; estimation of total annual number of visits per site; and es...

  12. Burden in the main caregiver

    Directory of Open Access Journals (Sweden)

    Fabiola Yonte Huete

    2010-09-01

    Full Text Available Objectives: The main objective is to determine the degree of burden in the main caregivers of dependent patients, to analyse the profile of informal caregivers and dependent patients. Their claims and help received with caring, the influence of mental deteriorate and duration of care giving regarding the burden of caregivers.Methods: Descriptive cross-sectional observational study amongst 50 caregivers and dependents. We used descriptive statistics and correlational studies. Results: 86 % of caregivers were women, middle aged, son/daughter of the dependent, married, with basic studies, no work outside the home, the average time in the role of caregiver was 16,96 hours a day and 2,1 free hours a day. 64 % of them received family support and 68 % wish to receive economic aid. It was found that for 38 % of the caregivers there was no burden at all, 34 % of them had a minimum burden and 28 % a greater burden.Conclusion: There are some caregivers with moderate or great burden. Our caregiver wishes to receive economic help. Our research shows that the decrease of mental health and the years of evolution do not have a significant statistically influence on caregivers. It is necessary prioritize the interventions and its recipients, provide solutions for caregivers with a greater burden, trying to keep away “caregiver syndrome”.

  13. Dravet syndrome: the main issues.

    Science.gov (United States)

    Guerrini, Renzo

    2012-09-01

    Dravet syndrome (DS) is a severe form of infantile onset epilepsy characterized by multiple seizure types, prolonged convulsive seizures and frequent episodes of status epilepticus. Seizures precipitated by fever are a main characteristic. Affected children exhibit normal early development. Cognitive impairment, behavioral disturbances with hyperactivity and sometimes autistic traits occur after seizure onset. Seizures persist into adulthood but become less frequent. In about 85% of patients, a mutation of the SCN1A gene is present. DS fully illustrates the concept of epileptic encephalopathy. However, it is difficult to determine the causative role of the underlying sodium channel dysfunction and that of the consequent seizures in influencing cognitive outcome. An overwhelmingly high number of SCN1A mutations have been associated with DS. Intragenic or whole gene deletions, duplications and amplifications are additional rare molecular mechanisms. Most mutations are de novo, but familial mutations also occur. Somatic mosaic mutations should be considered when estimating the recurrence. MRI imaging is usually normal, and no neuropathologic signature of the condition seems to exist. In heterozygous Scn1a+/- mice, GABAergic interneurons exhibit substantially reduced sodium current density with reduced ability for sustained action potential firing. GABAergic output is reduced and excitability of downstream synaptic targets increased. Stiripentol was effective in combination with valproate and clobazam in two pivotal phase III trials. Phenytoin, carbamazepine, and lamotrigine can worsen seizures and should be avoided. Prospective studies will clarify to what extent earlier diagnosis and efforts at seizure control with the most appropriate drug combinations will reduce clinical deterioration.

  14. Main challenges of residential areas

    Directory of Open Access Journals (Sweden)

    Oana Luca

    2017-06-01

    Full Text Available The present article is a position paper aiming to initiate a professional debate related to the aspects related to the urban dysfunctions leading to the wear of the residential areas. The paper proposes a definition of the wear process, identify the main causes leading to its occurrence and propose a number of solutions to neutralise the dysfunctions. The three wearing phases of residential areas components are emphasized, exploring their lifecycle. In order to perform the study of urban wear, the status of the residential areas components can be established and monitored, and also the variables of the function that can mathematically model the specific wear process may be considered. The paper is considered a first step for the model adjustment, to be tested and validated in the following steps. Based on the mathematical method and model, there can be created, in a potential future research, the possibility of determining the precarity degree for residential areas/neighbourhoods and cities, by minimising the subjective component of the analyses preceding the decision for renovation or regeneration.

  15. Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells.

    Science.gov (United States)

    Hsu, Y-C; Chen, M-J; Huang, T-Y

    2014-02-27

    Cucurbitacin E (CuE) is a natural compound previously shown to have anti-feedant, antioxidant and antitumor activities as well as a potent chemo-preventive action against cancer. The present study investigates its anti-proliferative property using MTT assay; CuE demonstrated cytotoxic activity against malignant glioma GBM 8401 cells and induced cell cycle G2/M arrest in these cells. CuE-treated cells accumulated in metaphase (CuE 2.5-10 μM) as determined using MPM-2 by flow cytometry. We attempted to characterize the molecular pathways responsible for cytotoxic effects of CuE in GBM 8401 cells. We studied the genome-wide gene expression profile on microarrays and molecular networks by using pathway analysis tools of bioinformatics. The CuE reduced the expression of 558 genes and elevated the levels of 1354 genes, suggesting an existence of the common pathways involved in induction of G2/M arrest. We identified the RB (GADD45β and GADD45γ) and the p53 (GADD45α) signaling pathways as the common pathways, serving as key molecules that regulate cell cycle. Results indicate that CuE produced G2/M arrest as well as the upregulation of GADD45 γ and binding with CDC2. Both effects increased proportionally with the dose of CuE, suggesting that the CuE-induced mitosis delay is regulated by GADD45γ overexpression. Our findings suggest that, in addition to the known effects on cancer prevention, CuE may have antitumor activity in glioma therapy.

  16. Maine Students Learn to Appreciate Diversity.

    Science.gov (United States)

    Flood, Pamela S.

    1994-01-01

    The Maine studies program at a rural Maine middle school begins in the sixth grade and expands through the eighth grade. Students camp out, explore Maine's geography, and learn about themselves, their state's history, and the state's diverse populations. Two multischool programs, Exchanging Maine's Cultures and the Curriculum Integration…

  17. 狼疮肾炎患者anti-GBM与anti-dsDNA和anti-NuA相关性研究%Anti- GBM and Anti- ds DNA Associated with Anti- NuA in Patients with Lupus Nephritis

    Institute of Scientific and Technical Information of China (English)

    李成海; 张聪恪; 赵静; 邹国林

    2006-01-01

    目的 探讨狼疮肾炎患者抗肾小球基底膜抗体(anti-GBM)与抗双链DNA抗体(anti-ds DNA)和抗核小体抗体(anti-NuA)的关系.方法 反馈分析28例anti-GBM阳性的狼疮肾炎患者致肾炎抗体间的关系.结果 28例anti-GBM阳性的狼疮性肾炎患者有13例anti-ds DNA阳性和17例anti-NuA阳性.并且,血清anti-GBM的水平与anti-ds DNA和/或anti-NuA水平一致.结论 anti-GBM与anti-ds DNA和anti-NuA呈正相关;联合检测这些肾炎抗体对疾病的治疗和预后判断有指导意义.

  18. 30 CFR 57.6160 - Main facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main facilities. 57.6160 Section 57.6160...-Underground Only § 57.6160 Main facilities. (a) Main facilities used to store explosive material underground... facilities will not prevent escape from the mine, or cause detonation of the contents of another storage...

  19. Riigikogu maine ja armastus / Aune Past

    Index Scriptorium Estoniae

    Past, Aune, 1954-

    2007-01-01

    Autor arutleb Riigikogu maine üle, toetudes TÜ ajakirjanduse ja kommunikatsiooni osakonna 2007. aastal tehtud uuringu tulemustele. Riigikogu liikmete maine paraneks, kui neil endil oleks selge, mis eesmärgil Toompeale mindi ja sellest siis ka rahvale kõneldaks

  20. Riigikogu maine ja armastus / Aune Past

    Index Scriptorium Estoniae

    Past, Aune, 1954-

    2007-01-01

    Autor arutleb Riigikogu maine üle, toetudes TÜ ajakirjanduse ja kommunikatsiooni osakonna 2007. aastal tehtud uuringu tulemustele. Riigikogu liikmete maine paraneks, kui neil endil oleks selge, mis eesmärgil Toompeale mindi ja sellest siis ka rahvale kõneldaks

  1. 78 FR 34701 - Maine Disaster #ME-00037

    Science.gov (United States)

    2013-06-10

    ... ADMINISTRATION Maine Disaster ME-00037 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Maine dated 05/30/2013. Incident: Commercial and Residential Building Complex Fire. Incident Period: 05/03/2013. Effective Date:...

  2. 78 FR 34701 - Maine Disaster #ME-00036

    Science.gov (United States)

    2013-06-10

    ... ADMINISTRATION Maine Disaster ME-00036 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Maine dated 05/30/2013. Incident: Apartment Complex Fire. Incident Period: 04/29/2013. Effective Date: 05/30/2013. Physical...

  3. Maine's Employability Skills Program

    Science.gov (United States)

    McMahon, John M.; Wolffe, Karen E.; Wolfe, Judy; Brooker, Carrie

    2013-01-01

    This Practice Report describes the development and implementation of the "Maine Employability Skills Program," a model employment program developed by the Maine Division for the Blind and Visually Impaired (DBVI). The program was designed to support the efforts of the chronically unemployed or underemployed. These consumers were either…

  4. Alcid Nesting Habitat on the Maine Coast

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Maine supports an extensive seabird population because of the abundance of relatively inaccessible rocky coastal islands which are ideal nesting grounds for many...

  5. Distributed PV Adoption in Maine Through 2021

    Energy Technology Data Exchange (ETDEWEB)

    Gagnon, Pieter; Sigrin, Ben

    2015-11-06

    NREL has used its dSolar (distributed solar) model to generate low-medium-high estimates of distributed PV adoption in Maine through 2021. This presentation gives a high-level overview of the model and modeling results.

  6. Hillshades for the main 8 Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These hillshade datasets were derived from USGS 7.5' DEM Quads for the main 8 Hawaiian Islands. Individual DEM quads were first converted to a common datum, and...

  7. Libraries in Maine: MedlinePlus

    Science.gov (United States)

    ... 602-2386 http://www.une.edu/library/ Lewiston Bates College Ladd Library 48 Campus Avenue Lewiston, ME 04240-6087 207-786-6471 http://abacus.bates.edu/Library/ Central Maine Medical Center Gerrish-True ...

  8. Superconducting magnets for the LHC main lattice

    CERN Document Server

    Rossi, L

    2004-01-01

    The main lattice of the Large Hadron Collider (LHC) will employ about 1600 main magnets and more than 4000 corrector magnets. All superconducting and working in pressurized superfluid helium bath, these impressive line of magnets will fill more than 20 km of the underground tunnel. With almost 70 main dipoles already delivered and 10 main quadrupoles almost completed, we passed the 5% of the production and now all manufacturers have fully entered into series production. In this paper the most critical issues encountered in the ramping up in such a real large scale fabrication will be addressed: uniformity of the coil size and of prestress, special welding technique, tolerances on curvature (dipoles) or straightness (quadrupoles) and of the cold mass extremities, harmonic content and, most important, the integrated field uniformity among magnets. The actual limits and the solution for improvements will be discussed. Finally a realistic schedule based on actual achievements is presented.

  9. Mercury in bird eggs from coastal Maine

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Maine's coastal islands and beaches provide important nesting habitat for piping plover (Charadrius melodus), least tern (Sterna antillarum), common tern (Sterna...

  10. Station Management Plan Maine Coastal Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This management plan outlines how four Maine refuges and twelve islands and one peninsula should be managed over the next three to five years. Plan results are...

  11. Investigation of Tidal Power, Cobscook Bay, Maine.

    Science.gov (United States)

    1980-08-01

    240 megawatt project on the Rance River in France and a 400 kilowatt station on the Kislaya Guba Gulf in the Soviet Union. Recently, studies have taken...Tidal Power Project, Maine" October 1979. 44. Ploch, Lousi A. and Nelson L. LeRoy, "Social and Economic Consequen- ces of the Dickey- Lincoln School...Regional Planning Commission," Machias, Maine, 1977. 47. U.S. Department of Energy, Southeast Power Administration, Dickey- Lincoln School Project

  12. Molecular clusters of the main group elements

    CERN Document Server

    Driess, Matthias

    2008-01-01

    ""To summarize, Molecular Clusters of the Main Group Elements is certainly not a popular science book, nor is it a textbook; it is a very good, up-to-date collection of articles for the specialist. Als Fazit bleibt: Molecular Clusters of the Main Group Elements ist sicher kein populissenschaftliches Werk, auch kein Lehrbuch, aber eine gelungene, hoch aktuelle Zusammenstellung fen interessierten Fachmann."" -Michael Ruck, TU Dresden, Angewandte Chemie, 2004 - 116/36 + International Edition 2004 - 43/36

  13. Aneurysm of the left main coronary artery

    Directory of Open Access Journals (Sweden)

    Ênio E. Guérios

    2000-12-01

    Full Text Available Aneurysm of the left main coronary artery is a rare angiographic finding, with few cases described in the international literature. We report the case of a 42-year-old male with a previous history of acute myocardial infarction, whose coronariography indicated triple vessel coronary disease and an aneurysm of the left main coronary artery. A review of the etiology, clinical aspects, and surgical management of coronary arterial aneurysm is presented.

  14. Main Development Targets for CNOOC in 2000

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    @@ In order to obtain stable reserves and create scope economic management, the China National Offshore Oil Corporation (CNOOC) officially put forward the main development target and main sci-tech sector target of the Ninth Five-Year Plan in July, 1995. These targets aim to make CNOOC as an international group corporation,including exploration and development of oil and gas,refining, petrochemicals, chemical fertilizer, power generation, unitizing sales network of up and down stream.

  15. CHMP推荐Temodal治疗GBM

    Institute of Scientific and Technical Information of China (English)

    罗娟(摘)

    2005-01-01

    美国药物制造商Schering—Plough公司称欧洲医药局人用药产品委员会(CHMP)已推荐它生产的Ternodal(temozolomide,替莫唑胺)(Ⅰ)作为治疗新诊断的多形恶性胶质细胞瘤(GBM)的一线药物。

  16. Main building fire drill safely concluded

    CERN Multimedia

    CERN Bulletin

    2015-01-01

    Last week, a simulated fire in the stairwell of the Main Building put CERN’s emergency response procedures to the test.   Firefighters descend the stairwell in the Main Building as the simulated fire rises.   At 2 p.m. on 22 September, alarms sounded around CERN’s Main Building as an evacuation exercise got underway. A simulated fire in the  stairwell, complete with very realistic smoke, led to the evacuation of one of the busiest places at CERN. The Main Building complex includes the Carlson Wagonlit travel agency, the post office, UBS, Uniqa, the Users Office, the Staff Association and the Novae restaurant as well as the Main Auditorium, the Council Chamber and the Charpak meeting room. It was impressive to see how quickly the smoke propagated in the staircase as well as into the corridors, and equally impressive to see how smoothly, quickly and efficiently the evacuation proceeded. The...

  17. Main Coast Winds - Final Scientific Report

    Energy Technology Data Exchange (ETDEWEB)

    Jason Huckaby; Harley Lee

    2006-03-15

    The Maine Coast Wind Project was developed to investigate the cost-effectiveness of small, distributed wind systems on coastal sites in Maine. The restructuring of Maine's electric grid to support net metering allowed for the installation of small wind installations across the state (up to 100kW). The study performed adds insight to the difficulties of developing cost-effective distributed systems in coastal environments. The technical hurdles encountered with the chosen wind turbine, combined with the lower than expected wind speeds, did not provide a cost-effective return to make a distributed wind program economically feasible. While the turbine was accepted within the community, the low availability has been a negative.

  18. The double main sequence of Omega Centauri

    CERN Document Server

    Bedin, L R

    2004-01-01

    Recent, high precision photometry of Omega Centauri, the biggest Galactic globular cluster, has been obtained with Hubble Space Telescope. The color magnitude diagram reveals an unexpected bifurcation of colors in the main sequence (MS). The newly found double MS, the multiple turnoffs and subgiant branches, and other sequences discovered in the past along the red giant branch of this cluster add up to a fascinating but frustrating puzzle. Among the possible explanations for the blue main sequence an anomalous overabundance of helium is suggested. The hypothesis will be tested with a set of FLAMES@VLT data we have recently obtained (ESO DDT program), and with forthcoming ACS@HST images.

  19. [Risk factors of main cancer sites].

    Science.gov (United States)

    Uleckiene, Saule; Didziapetriene, Janina; Griciūte, Liudvika Laima; Urbeliene, Janina; Kasiulevicius, Vytautas; Sapoka, Virginijus

    2008-01-01

    Cancer prevention is a system of various measures devoted to avoid this disease. Primary cancer prevention means the identification, avoidance, or destruction of known risk factors. The main risk factors are smoking, diet, alcohol consumption, occupational factors, environmental pollution, electromagnetic radiation, infection, medicines, reproductive hormones, and lack of physical activity. Approximately one-third of cancers can be avoided by implementing various preventive measures. The aim of this article was to acquaint medical students, family doctors with risk factors of main cancer sites (lung, breast, colorectal, and prostate).

  20. 78 FR 42556 - Maine Yankee Atomic Power Company; Maine Yankee Atomic Power Plant Issuance of Environmental...

    Science.gov (United States)

    2013-07-16

    ... COMMISSION Maine Yankee Atomic Power Company; Maine Yankee Atomic Power Plant Issuance of Environmental..., 2011, with various implementation dates for each of the rule changes. Maine Yankee Atomic Power Company... ADAMS, which provides text and image files of NRC's public documents. If you do not have access to...

  1. 76 FR 59177 - Maine Disaster #ME-00029

    Science.gov (United States)

    2011-09-23

    ... ADMINISTRATION Maine Disaster ME-00029 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major ] disaster for Public Assistance Only for the... Kingsport Road, Fort Worth, TX 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of...

  2. Kommunikatsioon ja maaelu maine / Ants Laansalu

    Index Scriptorium Estoniae

    Laansalu, Ants, 1938-2011

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 156-159. Autori hinnangul mõjutas meedias EL-i põllumajanduspoliitika kohta loodud negatiivne maine oluliselt Eesti põllumajanduspoliitika kujundamist riigi tasandil kuni 2000. a. ja ettevõtlus tasandil kuni 2003. a.

  3. Water Hammer in Pumped Sewer Mains

    DEFF Research Database (Denmark)

    Larsen, Torben

    This publication is intended for engineers seeking an introduction to the problem of water hammer in pumped pressure mains. This is a subject of increasing interest because of the development of larger and more integrated sewer systems. Consideration of water hammer is essential for structural...

  4. Main Strategies for Autonomous Robotic Controller Design

    OpenAIRE

    Paterega, I.

    2011-01-01

    This review gives an overall introduction to the artificial evolution mechanism. It presents the main strategies for robotic controller design. It gives a review of the pertinent literature, focusing on approaches that use neural networks, evolutionary computing, and fuzzy logic. Various applications of artificial evolution in robotics are surveyed and classified.

  5. Main facts 1995; Faits marquants 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    This report presents the main facts of the studies carried out by the Direction des Etudes et Recherches (DER) of Electricite de France: new applications of electricity, classical and nuclear thermal power plants, electrical equipment, environment protection, monitoring and plants operations.

  6. Rotor dynamic analysis of main coolant pump

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chong Won; Seo, Jeong Hwan; Kim, Choong Hwan; Shin, Jae Chul; Wang, Lei Tian [Korea Advanced Institute of Science and Technology, Taejon (Korea)

    1999-03-01

    A rotor dynamic analysis program DARBS/MCP, for the main coolant pump of the integral reactor, has been developed. The dynamic analysis model of the main coolant pump includes a vertical shaft, three grooved radial journal bearings and gaps that represent the structure-fluid interaction effects between the rotor and the lubricant fluid. The electromagnetic force from the motor and the hydro-dynamic force induced by impeller are the major sources of vibration that may affect the rotor system stability. DARBS/MCP is a software that is developed to effectively analyze the dynamics of MCP rotor systems effectively by applying powerful numerical algorithms such as FEM with modal truncation and {lambda}-matrix method for harmonic analysis. Main design control parameters, that have much influence to the dynamic stability, have been found by Taguchi's sensitivity analysis method. Design suggestions to improve the stability of MCP rotor system have been documented. The dynamic bearing parameters of the journal bearings used for main coolant pump have been determined by directly solving the Reynolds equation using FDM method. Fluid-structure interaction effect that occurs at the small gaps between the rotor and the stator were modeled as equivalent seals, the electromagnetic force effect was regarded as a linear negative radial spring and the impeller was modeled as a rigid disk with hydrodynamic and static radial force. Although there exist critical speeds in the range of operational speeds for type I and II rotor systems, the amplitude of vibration appears to be less than the vibration limit set by the API standards. Further more, it has been verified that the main design parameters such as the clearance and length of journal bearings, and the static radial force of impeller should be properly adjusted, in order to the improve dynamic stability of the rotor system. (author). 39 refs., 81 figs., 17 tabs.

  7. THE MAIN PRINCIPLES OF TOTAL QUALITY MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Andrei DIAMANDESCU

    2016-06-01

    Full Text Available Nowadays the industry is one of the main economic sectors, with a major contribution to achieving and maintaining a high rate of economic growth. The processing industry operation to high economic performance requires changes in structural terms, the re-engineering of processes and management. In this regard, one of the main actions taken at the level of companies in the manufacturing industry is the implementation of quality systems. Practicing quality management system not only allows businesses to react to changes taking place in business, but also to inflict them by the controlling of the future. This paper aims to analyze the principles of Total Quality Management – TQM and will highlight the advantages that organizations could obtain by applying each principle separately in the process of management.

  8. MAIN APPROACHES TO BUSINESS DEVELOPMENT STRATEGY FORMATION

    Directory of Open Access Journals (Sweden)

    D. B. Smirnov

    2015-01-01

    Full Text Available Article tasks: defi ne main approaches to business development strategy formation. Methodology: methodological basis includes systemic, replication and dialectic general scientifi c approaches. Results: it is established that the activity approach as a leading methodology of strategy development assumes correlation between the activity category and the concepts: needs, interests, incentives, goals, refl ection (evaluation, and self-development. Systemic approach assumes to consider strategy as a system having a defi nite structure and interconnections within the system components. Conclusions/relevance: for Russian businesses the main goal in the management system is not a prompt response to current environmental changes, but formation of a strategic vision of the business’ future, elaboration of a fl exible and viable development strategy, to foresee tactical and strategic threats for the business activity, to remove them timely, as well as to use strategic management ideas in practice for sustainable growth.

  9. Spiropyran main-chain conjugated polymers.

    Science.gov (United States)

    Sommer, Michael; Komber, Hartmut

    2013-01-11

    The first main-chain conjugated copolymers based on alternating spiropyran (SP) and 9,9-dioctylfluorene (F8) units synthesized via Suzuki polycondensation (SPC) are presented. The reaction conditions of SPC are optimized to obtain materials of type P(para-SP-F8) with appreciably high molecular weights up to M(w) ≈ 100 kg mol(-1). (13)C NMR is used to identify the random orientation of the non-symmetric SP unit in P(p-SP-F8). Ultrasound-induced isomerization of P(p-SP-F8) to the corresponding merocyanine form P(p-MC-F8) yields a deep-red solution. This isomerization reaction is followed by (1)H NMR in solution using sonication, whereby the color increasingly changes to deep red. The possibility to incorporate multiple SP units into main-chain polymers significantly broadens existing SP-based polymeric architectures.

  10. Early history of the Fermilab Main Ring

    Energy Technology Data Exchange (ETDEWEB)

    Malamud, E.; /Fermilab

    1983-10-01

    This note is written in response to a request from Phil Livdahl for corrections, and additions to a TM he is writing on Staffing Levels at Fermilab during Initial Construction Years and to a note that Hank Hinterberger is preparing on milestones. In my spare time over the past few years I have taken the original files of the Main Ring Section, my own notes from that period, and various other collections of relevant paper, and arranged them in a set of 44 large loose leaf binders in chronological order. I call this set of volumes the 'Main Ring Chronological Archives'. In response to Phil's request I have recently skimmed through these records of the period and extracted a small subset of documents which relate to the specific questions that Phil is addressing: staffing. administration, and milestones.

  11. The geomagnetic main field and the geodynamo

    Science.gov (United States)

    Bloxham, Jeremy; Roberts, Paul H.

    1991-01-01

    Information available on the geomagnetic main field and the geodynamo is presented. Attention is given to the process of mapping the magnetic field, the last version of International Geomagnetic Reference Field Model, and maps of the magnetic field at the core-mantle boundary and their interpretation. Particular consideration is given to the existing geodynamo theories, with special relation given to the Braginsky and Meytlis theory of core turbulence in which the turbulence differs fundamentally from classical turbulence of Kolmogorov type.

  12. DR21 Main: A Collapsing Cloud

    OpenAIRE

    Kirby, Larry

    2008-01-01

    The molecular cloud, DR21 Main, is an example of a large-scale gravitational collapse about an axis near the plane of the sky where the collapse is free of major disturbances due to rotation or other effects. Using flux maps, polarimetric maps, and measurements of the field inclination by comparing the line widths of ion and neutral species, we estimate the temperature, mass, magnetic field, and the turbulent kinetic, mean magnetic, and gravitational potential energies, and present a 3D model...

  13. INNOVATION DIFFUSION THEORY MAIN DEVELOPMENT STAGES

    Directory of Open Access Journals (Sweden)

    S. V. Lisafiev

    2011-01-01

    Full Text Available Abstract: Main innovation diffusion development theory stages are: Rogers model of moving new products to the market including characteristics of its segments; mathematic substantiation of this model by Bass; Moor model taking into account gaps between adjacent market segments; Goldenberg model making it possible to predict sales drops at new product life cycle initial stages. It is reasonable to use this theory while moving innovative products to the market.

  14. MAIN DIRECTIONS OF ELECTRONIC LINGUODIDACTIС DEVELOPMENT

    OpenAIRE

    Oksana A. Kucheruk

    2014-01-01

    Article considers the problem of electronic linguistics. In the article it is grounded topicality of creating and using of new software tools of information and communication technologies to improve the quality of Ukrainian-language education. By the analysis and synthesis of scientific and methodological ideas we have defined the main directions of development of the domestic electronic linguistics. These areas relate to the development of electronic lexicographic works for educational purpo...

  15. Nitrogen chronology of massive main sequence stars

    CERN Document Server

    Köhler, K; Brott, I; Langer, N; de Koter, A

    2012-01-01

    Rotational mixing in massive main sequence stars is predicted to monotonically increase their surface nitrogen abundance with time. We use this effect to design a method for constraining the age and the inclination angle of massive main sequence stars, given their observed luminosity, effective temperature, projected rotational velocity and surface nitrogen abundance. This method relies on stellar evolution models for different metallicities, masses and rotation rates. We use the population synthesis code STARMAKER to show the range of applicability of our method. We apply this method to 79 early B-type main sequence stars near the LMC clusters NGC 2004 and N 11 and the SMC clusters NGC 330 and NGC 346. From all stars within the sample, 17 were found to be suitable for an age analysis. For ten of them, which are rapidly rotating stars without a strong nitrogen enhancement, it has been previously concluded that they did not evolve as rotationally mixed single stars. This is confirmed by our analysis, which fla...

  16. Isolated systems with wind power. Main report

    Energy Technology Data Exchange (ETDEWEB)

    Lundsager, P.; Bindner, H.; Clausen, N.E.; Frandsen, S.; Hansen, L.H.; Hansen, J.C.

    2001-06-01

    The overall objective of this research project is to study the development of methods and guidelines rather than 'universal solutions' for the use of wind energy in isolated communities. The main specific objective of the project is to develop and present a more unified and generally applicable approach for assessing the technical and economical feasibility of isolated power supply systems with wind energy. As a part of the project the following tasks were carried out: Review of literature, field measurements in Egypt, development of an inventory of small isolated systems, overview of end-user demands, analysis of findings and development of proposed guidelines. The project is reported in one main report and four topical reports, all of them issued as Risoe reports. This is the Main Report Risoe-R-1256, summing up the activities and findings of the project and outlining an Implementation Strategy for Isolated Systems with Wind Power, applicable for international organisations such as donor agencies and development banks. (au)

  17. Use of energy piles in the Main Tower high-rise building, Frankfurt/Main; Einsatz von Energiepfaehlen am Beispiel des Main Tower im Frankfurt am Main

    Energy Technology Data Exchange (ETDEWEB)

    Hude, N. von der [Bilfinger und Berger Bauaktiengesellschaft, Mannheim (Germany). Service Center Technik; Kapp, C. [NEK Umwelttechnik AG, Zuerich (Switzerland)

    1998-03-01

    The ``Main Tower``, with a height of 198 m, is one of Europe`s highest and most innovative office buildings. The building has a pile foundation which is at the same time a component of the energy supply concept: The piles are equipped with heat exchanger tubes, so that the soil can be utilized for heat supply down to a depth of 50 m. There are several interfaces between foundation work and technical facilities. The number of cogeneration units required for supply of the building could be reduced accordingly. (orig.) [Deutsch] Im Bankenviertel der Innenstadt von Frankfurt am Main entsteht eines der hoechsten und modernsten Buerogebaeude Europas. Der 198 m hohe Neubau des Main Tower zeichnet sich dadurch aus, dass durch die Nutzung des Energiepotentials im Untergrund ein innovatives Energiekonzept verwirklicht wird. Das Hochhaus ist auf Grossbohrpfaehlen gegruendet. Sie dienen der Lastabtragung und sind, wie die Pfaehle der ueberschnittenen Bohrpfahlwand zur Baugrubensicherung, Bestandteil des Energiekonzeptes. Die Pfaehle wurden mit Waermetauscherrohren ausgestattet, um den Boden unterhalb des Hochhauses bis in eine Tiefe von 50 m unter Gelaendeoberkante zur umweltfreundlichen Energiegewinnung zu nutzen. Daraus ergeben sich eine Vielzahl von Schnittstellen zwischen Gruendungsarbeiten und technischer Gebaeudeausruestung. Dem Bauherrn wurde es ermoeglicht, die Zahl der erforderlichen Blockheizkraftwerke zur Versorgung des Gebaeudes nennenswert zu reduzieren. (orig.)

  18. ELECTRE METHODS: MAIN FEATURES AND RECENT DEVELOPMENTS

    Directory of Open Access Journals (Sweden)

    Jose Rui Figueira

    2010-12-01

    Full Text Available We present main characteristics of Electre family methods, designed for multiple criteria decision aiding. These methods use as a preference model an outranking relation in the set of actions – it is constructed in result of concordance and non-discordance tests involving a specific input preference information. After a brief description of the constructivist conception in which the Electre methods are inserted, we present the main features of these methods. We discuss such characteristic features as: the possibility of taking into account positive and negative reasons in the modeling of preferences, without any need for recoding the data; using of thresholds for taking into account the imperfect knowledge of data; the absence of systematic compensation between “gains” and “losses”. The main weaknesses are also presented. Then, some aspects related to new developments are outlined. These are related to some new methodological developments, new procedures, axiomatic analysis, software tools, and several other aspects. The paper ends with conclusions.

  19. Period Determination of Six Main Belt Asteroids

    Science.gov (United States)

    Ferrero, Andrea

    2014-07-01

    Observations of six main-belt asteroids (MBA) produced lightcurve parameters of: 487 Venetia, P = 13.34 ± 0.01 h, A = 0.20 mag; 684 Hildburg, P = 15.89 ± 0.01 h, A = 0.22 mag; 772 Tanete, P = 8.629 ± 0.001 h, A = 0.18 mag.; 1181 Lilith, P = 15.04 ± 0.01 h, A = 0.11 mag.; 1246 Chaka, P = 25.44 ± 0.01 h, A = 0.25 mag.; and 2834 Christy Carol, P = 12.79 ± 0.01 h, A = 0.39 mag.

  20. The main determinants affecting economic growth

    Directory of Open Access Journals (Sweden)

    Florin Teodor BOLDEANU

    2015-12-01

    Full Text Available Growth theories highlight the evolution and trends in economic thought that shaped the way economic growth is perceived. From the early works of Adam Smith and Malthus to the present day researchers have tried to find the most important determinates that influence growth by formulating new and improved theories and models. In this article we try to offer our point of view in the evolution of the main factors that have an impact on economic growth. There is still not a consensus on the key determinants of growth and an all-encompassing model that includes all the influences has not yet been elaborated.

  1. Electrochemistry of Main-Group Phthalocyanines.

    Science.gov (United States)

    1981-07-30

    to follow a linear relationship with the function r/(ze) (radius/charge). This reltionshlp may be used to facilitate the design of photocatalysts with...ze) and a function of central metal ion has been published. We have recently completed a study of the electrochemistry of main- us n i. Figure I for...SiV 54 0.074 -540 CIA 111 67.5 0.044 915 -655 1570Experimental Secfio* CiGat el 76 0.040 865 -735 1600Clintl! 94 0.032 830 -715 1545The r.-:m grUp

  2. Conceptual SPL RF Main Power Coupler design

    CERN Document Server

    Montesinos, Eric

    2011-01-01

    While the upgrade plans of the LHC injectors had to be reduced in scope in 2010, the Superconducting Proton Linac (SPL) remains a fundamental element of plans for a possible future neutrino facility. Prototyping work is therefore continuing at CERN and the current focus is on the test of a first four cavity SPL-like cryomodule with full power. This report summarizes the parameters for the Main Power Coupler design as discussed and approved within the ‘Review of SPL RF power couplers’, held at CERN in March 2010.

  3. Main Ocular Manifestations in Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Sandra Saray Quignon Santana

    2009-12-01

    Full Text Available Rheumatoid arthritis is considered an autoimmune disease in which articular and extra articular manifestations are produced and contribute to alter the functional capacity of the individual. This study consists on performing a bibliographical review showing the main ocular manifestations in patients with rheumatoid arthritis. It is our purpose to give you our experiences to the students as well as the internal medicine, ophthalmology and rheumatologist residents about this topic. The ophthalmological consultation of sick patients contributes to the prevention of ocular illnesses which are characteristic of the base disease and improve the ocular health.

  4. Space shuttle main engine hardware simulation

    Science.gov (United States)

    Vick, H. G.; Hampton, P. W.

    1985-01-01

    The Huntsville Simulation Laboratory (HSL) provides a simulation facility to test and verify the space shuttle main engine (SSME) avionics and software system using a maximum complement of flight type hardware. The HSL permits evaluations and analyses of the SSME avionics hardware, software, control system, and mathematical models. The laboratory has performed a wide spectrum of tests and verified operational procedures to ensure system component compatibility under all operating conditions. It is a test bed for integration of hardware/software/hydraulics. The HSL is and has been an invaluable tool in the design and development of the SSME.

  5. Space Shuttle Main Engine Public Test Firing

    Science.gov (United States)

    2000-01-01

    A new NASA Space Shuttle Main Engine (SSME) roars to the approval of more than 2,000 people who came to John C. Stennis Space Center in Hancock County, Miss., on July 25 for a flight-certification test of the SSME Block II configuration. The engine, a new and significantly upgraded shuttle engine, was delivered to NASA's Kennedy Space Center in Florida for use on future shuttle missions. Spectators were able to experience the 'shake, rattle and roar' of the engine, which ran for 520 seconds - the length of time it takes a shuttle to reach orbit.

  6. Impact of Main Macroeconomic Indicators on Happiness

    Directory of Open Access Journals (Sweden)

    Yavuz Agan

    2016-01-01

    Full Text Available The relationship between economic welfare and happiness has been compounded by different conceptualizations and statistical approaches. Economic conditions influence the welfare and social well-being of the society. While the literature indicates a positive relationship between income levels and life satisfaction, it indicates negative relationships between inflation, unemployment and life satisfaction. In this paper we analyze the relationship between main macroeconomic variables of unemployment, inflation, per capita GDP and life satisfaction using data from 57 countries. We make use of the standard regression analysis and conclude that our method is sufficient to examine the relations and the stated macro variables are significantly affecting life satisfaction towards expected directions.

  7. Musculoskeletal disorders in main battle tank personnel

    DEFF Research Database (Denmark)

    Nissen, Lars Ravnborg; Guldager, Bernadette; Gyntelberg, Finn

    2009-01-01

    PURPOSE: To compare the prevalence of musculoskeletal disorders of personnel in the main battle tank (MBT) units in the Danish army with those of personnel in other types of army units, and to investigate associations between job function in the tank, military rank, and musculoskeletal problems......, and ankle. RESULTS AND CONCLUSIONS: There were only 4 women in the MBT group; as a consequence, female personnel were excluded from the study. The participation rate was 58.0% (n = 184) in the MBT group and 56.3% (n = 333) in the reference group. The pattern of musculoskeletal disorders among personnel...

  8. Isolated systems with wind power. Main report

    DEFF Research Database (Denmark)

    Lundsager, P.; Bindner, Henrik W.; Clausen, Niels-Erik;

    2001-01-01

    approach for assessing the technical and economical feasibility of isolated power supply systems with wind energy. As a part of the project the following tasks were carried out: Review of literature, fieldmeasurements in Egypt, development of an inventory of small isolated systems, overview of end......The overall objective of this research project is to study the development of methods and guidelines rather than "universal solutions" for the use of wind energy in isolated communities. The main specific objective of the project is to develop and present amore unified and generally applicable...... for Isolated Systems with Wind Power, applicable for international organisations such as donoragencies and development banks....

  9. Impact of Main Macroeconomic Indicators on Happiness

    Directory of Open Access Journals (Sweden)

    Yavuz Agan

    2009-10-01

    Full Text Available The relationship between economic welfare and happiness has been compounded by different conceptualizations and statistical approaches. Economic conditions influence the welfare and social well-being of the society. While the literature indicates a positive relationship between income levels and life satisfaction, it indicates negative relationships between inflation, unemployment and life satisfaction. In this paper we analyze the relationship between main macroeconomic variables of unemployment, inflation, per capita GDP and life satisfaction using data from 57 countries. We make use of the standard regression analysis and conclude that our method is sufficient to examine the relations and the stated macro variables are significantly affecting life satisfaction towards expected directions

  10. A gap clearing kicker for Main Injector

    CERN Document Server

    Kourbanis, I; Biggs, J; Brown, B; Capista, D; Jensen, C C; Krafczyk, G E; Morris, D K; Scott, D; Seiya, K; Ward, S R; Wu, G; Yang, M -J

    2012-01-01

    Fermilab Main Injector has been operating at high Beam Power levels since 2008 when multi-batch slip stacking became operational. In order to maintain and increase the beam power levels the localized beam loss due to beam left over in the injection kicker gap during slip stacking needs to be addressed. A set of gap clearing kickers that kick any beam left in the injection gap to the beam abort have been built. The kickers were installed in the summer of 2009 and became operational in November of 2010. The kicker performance and its effect on the beam losses will be described.

  11. Debris disks in main sequence binary systems

    CERN Document Server

    Trilling, D E; Stapelfeldt, K R; Rieke, G H; Su, K Y L; Gray, R O; Corbally, C J; Bryden, G; Chen, C H; Boden, A; Beichman, C A

    2006-01-01

    We observed 69 A3-F8 main sequence binary star systems using the Multiband Imaging Photometer for Spitzer onboard the Spitzer Space Telescope. We find emission significantly in excess of predicted photospheric flux levels for 9(+4/-3)% and 40(+7/-6)% of these systems at 24 and 70 microns, respectively. Twenty two systems total have excess emission, including four systems that show excess emission at both wavelengths. A very large fraction (nearly 60%) of observed binary systems with small (<3 AU) separations have excess thermal mission. We interpret the observed infrared excesses as thermal emission from dust produced by collisions in planetesimal belts. The incidence of debris disks around main sequence A3-F8 binaries is marginally higher than that for single old AFGK stars. Whatever combination of nature (birth conditions of binary systems) and nurture (interactions between the two stars) drives the evolution of debris disks in binary systems, it is clear that planetesimal formation is not inhibited to a...

  12. MAIN TOPICS,ABSTRACTS & KEY WORDS

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Design and implementation of a power control system for electron beam welder HE Shaojia, LI Jianling, MO Jinhai, LI Haibiao (School of Mechanical & Electrical Engineering, Guilin University of Electronic Technology, Guilin 541004, China). ppl-5, 12 Abstract: Stability of output voltage of high-voltage accelerating stabilized power supply for electron beam welder (EBW) is a prerequisite to ensure the electron beam welding quality. The common power supplies have the disadvantages of circuit complexity and bulkiness. A novel control system of higholtage accelerating stabilized power supply for EBW was designed. Its main circuit is based on pulse-width modulation (PWM) buckboost converter topology. Compared with common EBW power supplies, this new power supply requires a much lower voltage grade transformer because of the converter's effect for rising voltage, so its volume is smaller and the circuit is simpler. The sys- tem main circuit characteristics and its working process were analyzed. The system circuit's small-signal mathematical model was created, and lag-lead correction compensation control was em- ployed in the system to achieve static and dynamic performance requirements. The results displayed that this unit had the characteristics of fast response, high reliability, high control precision and anti-interference capability.

  13. Forensic entomology and main challenges in Brazil.

    Science.gov (United States)

    Gomes, Leonardo; Von Zuben, Cláudio J

    2006-01-01

    Apart from an early case report from China (13th century), the first observations on insects and other arthropods as forensic indicators were documented in Germany and France during mass exhumations in the 1880s by Reinhard, who is considered a co-founder of the discipline. After the French publication of Mégnin's popular book on the applied aspects of forensic entomology, the concept quickly spread to Canada and United States. At that time, researchers recognized that the lack of systematic observations of insects of forensic importance jeopardized their use as indicators of postmortem interval. General advances in insect taxonomy and ecology helped to fill this gap over the following decades. After World Wars, few forensic entomology cases were reported in the scientific literature. From 1960s to the 1980s, Leclercq and Nuorteva were primarily responsible for maintaining the method in Central Europe, reporting isolated cases. Since then, basic research in the USA, Russia and Canada opened the way to the routine use of Entomology in forensic investigations. Identifications of insects associated with human cadavers are relatively few in the literature of the Neotropical region and have received little attention in Brazil. This article brings an overview of historic developments in this field, the recent studies and the main problems and challenges in South America and mainly in Brazil.

  14. Main areas of the national economy modernization

    Directory of Open Access Journals (Sweden)

    Valeriy Anatolyevich Tsvetkov

    2011-06-01

    Full Text Available This paper shows the concept of modernization, its main areas related to the commodity sector and transport infrastructure are identified, it is proposed to consider the application in relation to the modernization of modernization of the commodity sector. The author connects the need to modernize the Russian economy with the task of doubling GDP, correcting structural imbalances, reducing the technological gap with the developed world, overcoming social polarization in income, fighting inflation and smoothing the growth of inter-regional contrasts. The aim of modernizing the Russian economy is to achieve high competitiveness of the national economy, which would put the Russian Federation in terms of living standards among the most developed countries, and would provide a decent position in the world. The fact that "breakthrough" sectors of the sixth technological structure cannot be the starting point of modernization is substantiated. The concept of national competitiveness is reviewed. The lack of a complete model of modernization in the world is highlighted. Two main areas in relation to the modernization of the Russian Federation are identified: modernization of the commodity sector, which should represent applied modernization based on the comparative advantages of the Russian economy; with respect to functionally interrelated industries (fuel and energy complex and the oil-gas and upgrading of transport infrastructure, which is so effective because of unique transit facilities and prospects of Russia.

  15. Water Hammer in Pumped Sewer Mains

    DEFF Research Database (Denmark)

    Larsen, Torben

    This publication is intended for students and engineers seeking an introduction to the problem of water transients in pumped sewer and water mains. This is a subject of increasing interest because of the development of larger and more integrated systems. Consideration of transients is essential...... for the structural design of pipelines and for the planning of the proper function of the systems. The text is written by Torben Larsen, who is a professor of environmental hydraulics at the Department of Civil Engineering, Aalborg University. Torben Larsen has many years of experience with computer simulations...... of transients in pumped pipeline systems. This present publication can be understood as the second and revised edition of the pamphlet ”Transients in pumped sewer mains” (2006) which was published as a technical report by The EVA committee under The Danish Water Pollution Committee (The Danish Society...

  16. PS main supply: motor-generator set.

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    In picture 04 the motor is on the right in the background and the main view is of the generator. The peak power in each PS cycle drawn from the generator, up to 96 MW, is taken from the rotational kinetic energy of the rotor (a heavy-weight of 80 tons), which makes the rotational speed drop by only a few percent. The motor replenishes the average power of 2 to 4 MW. Photo 05: The motor-generator set is serviced every year and, in particular, bearings and slip-rings are carefully checked. To the left is the motor with its slip-rings visible. It has been detached from the axle and moved to the side, so that the rotor can be removed from the huge generator, looming at the right.

  17. Siberian snakes for the Fermilab Main Injector

    Energy Technology Data Exchange (ETDEWEB)

    Anferov, V.A.; Baiod, R.; Courant, E.D. [and others

    1993-04-01

    Appropriate Siberian snakes were designed to maintain the proton beam polarization during acceleration in the Fermilab Main Injector from 8 to 150 GeV. Various snake designs were investigated to find one fitting into the 14 m straight section spaces with the required spin rotation axis and the minimum orbit excursion. The authors studied both cold and warm discrete magnet snakes as well as warm snakes with helical magnets. For the warm discrete magnet snake, obtaining small orbit excursions required a nearly longitudinal snake axis, while axes near {+-}45{degrees} are needed when using two snakes in a ring. The authors found acceptable snakes either by using superconducting magnets or by using warm magnets with a helical dipole field.

  18. Main injector particle production experiment at Fermilab

    Indian Academy of Sciences (India)

    Sonam Mahajan; Ashok Kumar; Rajendran Raja

    2012-11-01

    The main injector particle production (MIPP) experiment at Fermilab uses particle beams of charged pions, kaons, proton and antiproton with beam momenta of 5–90 GeV/c to measure particle production cross-sections of various nuclei including liquid hydrogen, MINOS target and thin targets of beryllium, carbon, bismuth and uranium. The physics motivation to perform such cross-section measurements is described here. Recent results on the analysis of NuMI target and forward neutron cross-sections are presented here. Preliminary cross-section measurements for 58 GeV/c proton on liquid hydrogen target are also presented. A new method is described to correct for low multiplicity inefficiencies in the trigger using KNO scaling.

  19. A random walk down Main Street

    Directory of Open Access Journals (Sweden)

    David Matthew Levinson

    2016-08-01

    Full Text Available US suburbs have often been characterized by their relatively low walk accessibility compared to more urban environments, and US urban environments have been char- acterized by low walk accessibility compared to cities in other countries. Lower overall density in the suburbs implies that activities, if spread out, would have a greater distance between them. But why should activities be spread out instead of developed contiguously? This brief research note builds a positive model for the emergence of contiguous development along “Main Street” to illustrate the trade-offs that result in the built environment we observe. It then suggests some policy interventions to place a “thumb on the scale” to choose which parcels will develop in which sequence to achieve socially preferred outcomes.

  20. Eccentricity distribution in the main asteroid belt

    CERN Document Server

    Malhotra, Renu

    2016-01-01

    The observationally complete sample of the main belt asteroids now spans more than two orders of magnitude in size and numbers more than 64,000 (excluding collisional family members). We undertook an analysis of asteroids' eccentricities and their interpretation with simple physical models. We find that Plummer's (1916) conclusion that the asteroids' eccentricities follow a Rayleigh distribution holds for the osculating eccentricities of large asteroids, but the proper eccentricities deviate from a Rayleigh distribution: there is a deficit of eccentricities smaller than $\\sim0.1$ and an excess of larger eccentricities. We further find that the proper eccentricities do not depend significantly on asteroid size but have strong dependence on heliocentric distance: the outer asteroid belt follows a Rayleigh distribution, but the inner belt is strikingly different. Eccentricities in the inner belt can be modeled as a vector sum of a primordial eccentricity vector of random orientation and magnitude drawn from a Ra...

  1. Natural syntax : English interrogative main clauses

    Directory of Open Access Journals (Sweden)

    Janez Oresnik

    2007-12-01

    Full Text Available Natural Syntax is a developing deductive theory, a branch of Naturalness Theory. The naturalnessjudgements are couched in naturalness scales, whichfollow from the basic parameters (or «axioms» listed at the beginning of the paper. The predictions of the theory are calculated in deductions, whose chief components are apair of naturalness scales and the rules governing the alignment of corresponding naturalness values. Parallel and chiastic alignments are distinguished, in complementary distribution. Chiastic alignment is mandatory in deductions limited to unnatural environments. The paper deals with English interrogative main clauses. Within these, only the interrogatives containing wh-words exclusively insitu constitute an extremely unnatural environment and require chiastic alignment. Otherwiseparallel alignment is used. Earlier publications on Natural Syntax: Kavcic 2005a,b, Oresnik 1999, 2000a,b, 200la-f   2002, 2003a-c, 2002/03, 2004. This list cites only works written in English.

  2. Photographic Volume Estimation of CPAS Main Parachutes

    Science.gov (United States)

    Ray, Eric S.

    2017-01-01

    Capsule Parachute Assembly System (CPAS) flight tests regularly stage a helicopter to observe inflation of 116 ft D o ringsail Main parachutes. These side views can be used to generate 3-D models of inflating canopies to estimate enclosed volume. Assuming a surface of revolution is inadequate because reefed canopies in a cluster are elongated due to mutual aerodynamic interference. A method was developed to combine the side views with upward looking HD video to account for non-circular cross sections. Approximating the cross sections as elliptical greatly improves accuracy. But since that correction requires manually tracing projected outlines, the actual irregular shapes can be used to generate high fidelity models. Compensation is also made for apparent tilt angle. Validation was accomplished by comparing perimeter and projected area with known line lengths and/or high quality photogrammetry.

  3. BANKING ETHICS: MAIN CONCEPTIONS AND PROBLEMS

    Directory of Open Access Journals (Sweden)

    VALENTINA FETINIUC

    2014-10-01

    Full Text Available Banking ethics is a specialized set of ethical standards and rules that should be followed in the activities of financial institutions and employees of the banking sector. But despite the simplicity of the definition, in the modern world, this concept becomes complex and ambiguous. The importance of studying this subject is defined by the fact that the ethical behavior of the bank and bank employees promotes banking. At present there are several conceptions of banking ethics: general ethics, regulated ethics and ethical bank. The most common practice is to regulate internal and external relations of banks and bank workers with ethical codes. At the same time, studies show the existence of problems in the banking standards of ethics, which negatively affects the financial institution. This article is intended to reflect main tendencies and problems of banking ethics at international level and experience of Republic of Moldova in this field.

  4. Heat piles: the `MAIN TOWER` in Frankfurt on the Main; Einsatz von Energiepfaehlen am Beispiel des MAIN TOWER in Frankfurt am Main

    Energy Technology Data Exchange (ETDEWEB)

    Kapp, C. [NEK Umwelttechnik AG, Zuerich (Switzerland); Hude, N. von der [Bilfinger und Berger Bauaktiengesellschaft, Mannheim (Germany). Service Center Technik

    1997-12-01

    In the inner-city banking quarter of Frankfurt on the Main, one of the highest and most modern office buildings of Europe has been being erected since the summer of 1996. The intersecting rows of drill-foundation piles required to secure the deep excavation and the load-bearing piles were designed as heat piles. Thereby the harnessing of shallow geothermal energy was integrated into the overall HVAC concept, realizing a highly innovative project. Although the erection of heat piles had only been decided on when planning for a conventional energy system was completed, the decision permitted to dispense with some of the usual components in the control station. As executed simulations show, integration of the piles into the overall concept of the building is not easy because the piles are exclusively used to provide cooling energy. But the project demonstrates that heat piles can nowadays be used also on a large scale. (orig.) [Deutsch] Im Bankenviertel in der Innenstadt von Frankfurt am Main entsteht seit dem Sommer 1996 eines der hoechsten und modernsten Buerogebaeude Europas. Die zur Sicherung der tiefen Baugrube erforderlichen Pfaehle der ueberschnittenen Bohrpfahlwand sowie diejenigen zum Lastabtrag wurden als Energiepfaehle ausgebildet. Damit wurde die Nutzung der untiefen Geothermie in das Gesamtkonzept der Haustechnik integriert und so ein innovatives Energiekonzept umgesetzt. Obwohl der Einsatz der Energiepfaehle erst dann beschlossen worden ist, als bereits eine konventionelle Energieversorgung vorgesehen und planerisch umgesetzt worden war, konnte dank der Energiepfaehle auf einige herkoemmliche Komponenten in der Energiezentrale verzichtet werden. Aufgrund der durchgefuehrten Simulationsberechnungen gestaltet sich die Einbindung ins Gesamtgebaeudekonzept nicht einfach, da die Energiepfaehle lediglich zu Kuehlzwecken verwendet werden. Trotzdem zeigt dieses Beispiel, dass heute Energiepfahlsysteme auch in grossem Massstab eingesetzt werden koennen. (orig.)

  5. Eccentricity distribution in the main asteroid belt

    Science.gov (United States)

    Malhotra, Renu; Wang, Xianyu

    2017-03-01

    The observationally complete sample of the main belt asteroids now spans more than two orders of magnitude in size and numbers more than 64 000 (excluding collisional family members). We undertook an analysis of asteroids' eccentricities and their interpretation with simple physical models. We find that a century old conclusion that the asteroids' eccentricities follow a Rayleigh distribution holds for the osculating eccentricities of large asteroids, but the proper eccentricities deviate from a Rayleigh distribution; there is a deficit of eccentricities smaller than ∼0.1 and an excess of larger eccentricities. We further find that the proper eccentricities do not depend significantly on asteroid size but have strong dependence on heliocentric distance; the outer asteroid belt follows a Rayleigh distribution, but the inner belt is strikingly different. Eccentricities in the inner belt can be modelled as a vector sum of a primordial eccentricity vector of random orientation and magnitude drawn from a Rayleigh distribution of parameter ∼0.06, and an excitation of random phase and magnitude ∼0.13. These results imply that when a late dynamical excitation of the asteroids occurred, it was independent of asteroid size and was stronger in the inner belt than in the outer belt. We discuss implications for the primordial asteroid belt and suggest that the observationally complete sample size of main belt asteroids is large enough that more sophisticated model-fitting of the eccentricities is warranted and could serve to test alternative theoretical models of the dynamical excitation history of asteroids and its links to the migration history of the giant planets.

  6. Remotely triggered earthquakes following moderate main shocks

    Science.gov (United States)

    Hough, S.E.

    2007-01-01

    Since 1992, remotely triggered earthquakes have been identified following large (M > 7) earthquakes in California as well as in other regions. These events, which occur at much greater distances than classic aftershocks, occur predominantly in active geothermal or volcanic regions, leading to theories that the earthquakes are triggered when passing seismic waves cause disruptions in magmatic or other fluid systems. In this paper, I focus on observations of remotely triggered earthquakes following moderate main shocks in diverse tectonic settings. I summarize evidence that remotely triggered earthquakes occur commonly in mid-continent and collisional zones. This evidence is derived from analysis of both historic earthquake sequences and from instrumentally recorded M5-6 earthquakes in eastern Canada. The latter analysis suggests that, while remotely triggered earthquakes do not occur pervasively following moderate earthquakes in eastern North America, a low level of triggering often does occur at distances beyond conventional aftershock zones. The inferred triggered events occur at the distances at which SmS waves are known to significantly increase ground motions. A similar result was found for 28 recent M5.3-7.1 earthquakes in California. In California, seismicity is found to increase on average to a distance of at least 200 km following moderate main shocks. This supports the conclusion that, even at distances of ???100 km, dynamic stress changes control the occurrence of triggered events. There are two explanations that can account for the occurrence of remotely triggered earthquakes in intraplate settings: (1) they occur at local zones of weakness, or (2) they occur in zones of local stress concentration. ?? 2007 The Geological Society of America.

  7. Is it time for elective left main percutaneous coronary intervention to become 'main stream'?

    Institute of Scientific and Technical Information of China (English)

    Joshua Cohen; Andrew D.Michaels

    2006-01-01

    @@ Left main (LM) stenting is considered by many to be one of the last frontiers of interventional cardiology. Beginning with the VA cooperative study published in 1976 demonstrating a mortality benefit for patients undergoing coronary artery bypass grafting (CABG), i the standard of care for treatment of left main coronary artery disease has been surgical.The most recent 2005 update of the ACC/AHA/SCAI Practice Guidelines on PCI 2 again notes that "CABG using IMA grafting is the 'gold standard' for treatment of unprotected left main disease and has proven benefit on long-term outcomes."

  8. Maine Environmental Vulnerability Index (EVI) Atlas, Maine - 2007, maps in portable document format (NODC Accession 0036827)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This four volume set of Environmental Vulnerability Index Maps depicts environmental resources along the coast of Maine most at risk from oil spilled into the marine...

  9. Flood of April 2007 in Southern Maine

    Science.gov (United States)

    Lombard, Pamela J.

    2009-01-01

    Up to 8.5 inches of rain fell from April 15 through 18, 2007, in southern Maine. The rain - in combination with up to an inch of water from snowmelt - resulted in extensive flooding. York County, Maine, was declared a presidential disaster area following the event. The U.S. Geological Survey, in cooperation with the Federal Emergency Management Agency (FEMA), determined peak streamflows and recurrence intervals at 24 locations and peak water-surface elevations at 63 sites following the April 2007 flood. Peak streamflows were determined with data from continuous-record streamflow-gaging stations where available and through hydraulic models where station data were not available. The flood resulted in peak streamflows with recurrence intervals greater than 100 years throughout most of York County, and recurrence intervals up to 50 years in Cumberland County. Peak flows for selected recurrence intervals varied from less than 10 percent to greater than 100 percent different than those in the current FEMA flood-insurance studies due to additional data or newer regression equations. Water-surface elevations observed during the April 2007 flood were bracketed by elevation profiles in FEMA flood-insurance studies with the same recurrence intervals as the recurrence intervals bracketing the observed peak streamflows at seven sites, with higher elevation-profile recurrence intervals than streamflow recurrence intervals at six sites, and with lower elevation-profile recurrence intervals than streamflow recurrence intervals at one site. The April 2007 flood resulted in higher peak flows and water-surface elevations than the flood of May 2006 in coastal locations in York County, and lower peak flows and water-surface elevations than the May 2006 flood further from the coast and in Cumberland County. The Mousam River watershed with over 13 dams and reservoirs was severely impacted by both events. Analyses indicate that the April 2007 peak streamflows in the Mousam River watershed

  10. CLIC Main Beam Quadrupole Eigen Mode computation

    CERN Document Server

    Deleglise, Guillaume

    2010-01-01

    In this report, we summarise the work done on the CLIC Main Beam Quadrupole. There are about 4000 MB quadrupoles of 4 types with lengths ranging from 420mm to 1900mm. In order to obtain the desired CLIC luminosity, the MB quadrupoles have to be stable to 1nm above 1Hz. The region of interest for the study is between 0.5Hz and about 100Hz. In order to achieve the specifications, the magnet should not have any resonance peaks in this region of Interest. In addition, the magnet on its support shouldn’t have any resonance peak in the same frequency range. The first step is to determine if the designed magnet has its first resonance peak above 100Hz. We are studying the longest quadrupole more susceptible to internal resonances. In a second step, the magnet on ideal supporting points has been evaluated. The current magnet design can be seen on following figure. One can see that it is composed of 4 quadrants assembled so as to have a quadrupole magnetic field. As a last step, the mechanical model has been used to...

  11. THINKING SKILL - THE MAIN LEARNING TOOL

    Directory of Open Access Journals (Sweden)

    Daniela Koteková

    2010-06-01

    Full Text Available The method of teaching with help of four elementary skills - reading, speaking, writing and listening is definitely inconceivable to teaching any foreign language. But automatic answers following the exercise and students passive memorising does not make speaking language and its learning very natural. This has forced me to find and create the way how to make learners think and realise the point and meaning of learning itself. My paper is about special skill I have tried to apply –thinking skill. I have chosen it to complement other four which teacher normally uses when teaching foreign language (reading, speaking, listening skills. At the same time I put thinking skill into a role to support and enhance learning process. To find and use some methods how to make students think, make their own opinion and also teach them to apply their own experience to learning process was the main goal of this survey. The methods I have applied were provoking students to think before they learn.

  12. Flood inundation map library, Fort Kent, Maine

    Science.gov (United States)

    Lombard, Pamela J.

    2012-01-01

    Severe flooding occurred in northern Maine from April 28 to May 1, 2008, and damage was extensive in the town of Fort Kent (Lombard, 2010). Aroostook County was declared a Federal disaster area on May 9, 2008. The extent of flooding on both the Fish and St. John Rivers during this event showed that the current Federal Emergency Management Agency (FEMA) Flood Insurance Study (FIS) and Flood Insurance Rate Map (FIRM) (Federal Emergency Management Agency, 1979) were out of date. The U.S. Geological Survey (USGS) conducted a study to develop a flood inundation map library showing the areas and depths for a range of flood stages from bankfull to the flood of record for Fort Kent to complement an updated FIS (Federal Emergency Management Agency, in press). Hydrologic analyses that support the maps include computer models with and without the levee and with various depths of backwater on the Fish River. This fact sheet describes the methods used to develop the maps and describes how the maps can be accessed.

  13. GAS MAIN SENSOR AND COMMUNICATIONS NETWORK SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Hagen Schempf, Ph.D.

    2003-02-27

    Automatika, Inc. was contracted by the Department of Energy (DOE) and with co-funding from the New York Gas Group (NYGAS), to develop an in-pipe natural gas prototype measurement and wireless communications system for assessing and monitoring distribution networks. A prototype system was built for low-pressure cast-iron mains and tested in a spider- and serial-network configuration in a live network in Long Island with the support of Keyspan Energy, Inc. The prototype unit combined sensors capable of monitoring pressure, flow, humidity, temperature and vibration, which were sampled and combined in data-packages in an in-pipe master-slave architecture to collect data from a distributed spider-arrangement, and in a master-repeater-slave configuration in serial or ladder-network arrangements. It was found that the system was capable of performing all data-sampling and collection as expected, yielding interesting results as to flow-dynamics and vibration-detection. Wireless in-pipe communications were shown to be feasible and valuable data was collected in order to determine how to improve on range and data-quality in the future.

  14. THE MAIN PROBLEM OF COUNTERACTION AGAINST CORRUPTION

    Directory of Open Access Journals (Sweden)

    Alexander Sergeevich Dilkov

    2015-01-01

    Full Text Available The article considers the problem of corruption. The experience of anti-corruption activities in various countries shows convincingly that to completely get rid of corruption is impossible, as any other social evil, with solid foundations in economic, social and political system of society. You can put a question only about how to reduce the scale of corruption to the socially acceptable level. Corruption infringes upon interests and constitutional rights of citizens, undermines the rule of law and democratic principles, suggests discrediting the activities of the state apparatus, distorts the principle of legality, hinders economic reforms and therefore requires detailed investigation with the scientific side to find the most effective ways of countering this phenomenon. Corruption can be done in different ways and methods. The conclusion that corruption is not only a form of criminal enrichment bureaucratic state apparatus, it has always been the main source of criminalization of social life, its degradation.Corruption is both a prerequisite and a consequence of the functioning of the shadow economy, strengthening property differentiation of the society, the fall of morals and degradation of the socio-political life.

  15. Primary Productivity in Meduxnekeag River, Maine, 2005

    Science.gov (United States)

    Goldstein, Robert M.; Schalk, Charles W.; Kempf, Joshua P.

    2009-01-01

    During August and September 2005, dissolved oxygen, temperature, pH, specific conductance, streamflow, and light intensity (LI) were determined continuously at six sites defining five reaches on Meduxnekeag River above and below Houlton, Maine. These data were collected as input for a dual-station whole-stream metabolism model to evaluate primary productivity in the river above and below Houlton. The river receives nutrients and organic matter from tributaries and the Houlton wastewater treatment plant (WWTP). Model output estimated gross and net primary productivity for each reach. Gross primary productivity (GPP) varied in each reach but was similar and positive among the reaches. GPP was correlated to LI in the four reaches above the WWTP but not in the reach below. Net primary productivity (NPP) decreased in each successive downstream reach and was negative in the lowest two reaches. NPP was weakly related to LI in the upper two reaches and either not correlated or negatively correlated in the lower three reaches. Relations among GPP, NPP, and LI indicate that the system is heterotrophic in the downstream reaches. The almost linear decrease in NPP (the increase in metabolism and respiration) indicates a cumulative effect of inputs of nutrients and organic matter from tributaries that drain agricultural land, the town of Houlton, and the discharges from the WWTP.

  16. Nature and main kinds of psychopathological mechanisms

    Directory of Open Access Journals (Sweden)

    Panagiotis Oulis

    2010-12-01

    Full Text Available The paper deals with two central issues in the philosophy of neuroscience and psychiatry, namely those of the nature and the major kinds and types of psychopathological mechanisms. Contrary to a widespread view, I argue that mechanisms are not kinds of systems but kinds of processes unfolding in systems or between systems. More precisely, I argue that psychopathological mechanisms are sets of actions and interactions between brain-systems or circuits as well as between the latter and other systems in one's body and external environment, both physical and social, involved in human psychopathology. According to the kinds of properties of the interacting systems or their component-parts, psychopathological mechanisms may be physical, chemical, biological, psychological, social, or, typically, mixed ones. Furthermore, I focus on two main kinds of psychopathological mechanisms involved in the causation of mental disorders, namely the pathogenetic and pathophysiological ones, stressing the importance of their careful distinction for the integrative understanding of otherwise disparate and apparently incommensurable psychiatric research findings. I illustrate my analysis with an example drawn from contemporary research on the mechanisms of acute psychosis. Finally, I stress the relevance of psychopathological mechanisms to a more scientifi cally-grounded classifi cation of mental disorders.

  17. Brand new hall in the main building

    CERN Multimedia

    Corinne Pralavorio

    2014-01-01

    The renovation of the UNIQA and post office premises is getting under way, with their reopening scheduled for the spring.   The renovation of the large hall in the main building (Building 500) has finally reached the home straight. As of this week, building contractors will get to work on the last part – the offices of UNIQA and La Poste. In the last week of November, the two concessions moved their offices across Route Scherrer to the same part of Building 510 where UBS was temporarily housed during the bank’s refurbishment. Their services were therefore unavailable for one day. The renovation work will last until the spring, with the new offices expected to open in May 2015. Between now and then, the windows and insulation will be completely refitted, with a view to reducing heat loss considerably, and, above all, the premises will be modernised to improve customer reception and service. For example, UNIQA’s new premises will feature a confidential area, guarantee...

  18. MAIN PROBLEMS OF CONTROLLING OF THE QUALITY

    Directory of Open Access Journals (Sweden)

    Orlov A. I.

    2015-09-01

    Full Text Available Controlling of statistical methods to ensure product quality is the special case of controlling organizational and economic methods of management. Today, controlling in the practice of management of Russian companies is understood as "the system of information-analytical and methodological support to achieve their goals." The controller is developing a decision-making rules, the head takes decisions on the basis of these rules. We proved the concept of "controlling of methods". Innovation in management is based, in particular, on the use of new adequate organizational-economic (as well as economicmathematical and statistical methods. Controlling in this area - is the development and application procedures of compliance management used and newly developed (implemented organizationaleconomic methods for the task. Thus, the methodology for controlling is of great practical value in any field in which the actions (operations must be carried out in accordance with certain rules (regulations, standards, guidelines, as in any such area in which we need to use development and application procedures of compliance management used and the newly established (implemented rules for solution of tasks assigned to the organization. In this article, we select a area of controlling as controlling quality, and we discuss its main issues. This is about controlling of organizational-economic methods to ensure product quality, especially about the statistical methods based on probability theory and mathematical statistics. We consider the analysis and synthesis of plans of statistical quality control, optimization options plans of statistical control, truncated plans. Are discussed the differences control plans provider and the consumer, the allocation of units formless (liquid, gas products, the selection of a random sample of the statistical quality control of products, lower estimate of the required sample size. It is established, that is not always necessary

  19. Hotel Intercontinental, en Frankfurt-Main (Alemania

    Directory of Open Access Journals (Sweden)

    Apel, Otto

    1966-09-01

    Full Text Available This building has basements, and 21 storeys above the ground. The basements are occupied with the usual services, and a garage, for clients, capable of holding 500 cars. The concierge’s office, the reception office, main hall, restaurant and services are on the ground floor. On the first floor there is a large ball room, where 600 people can assemble, as well as other reception halls. On each of the 2nd to 18th floors there are thirty rooms of one type, and eighteen of another. A luxury apartment occupies the 19th floor, and a restaurant for 200 people as well as a bar is on the top floor. This hotel, which is slab shaped, fits well with its environment and is very pleasantly proportioned.Consta de: planta de sótanos, planta baja y 20 plantas de altura. La planta de sótano contiene las distintas instalaciones; dependencias del personal, etcétera, y un garaje, reservado para los viajeros, capaz de albergar 500 coches. La planta baja comprende: la conserjería, recepción, hall, restaurantes, etc. En la planta primera existe una gran sala de baile para 600 personas, salas de reuniones, etc. Las plantas, de la 2.ª a la 18.ª contienen treinta habitaciones de un tipo y dieciocho de otro, en cada planta. En la planta 19.ª hay un apartamento de lujo. Y en la última planta se distribuyen: un restaurante para 200 personas, bar, etc. El bloque, dentro de su configuración paralelepipédica, es de forma armónica y está perfectamente encajado en el paisaje urbano circundante.

  20. Main points for 1991 family planning work.

    Science.gov (United States)

    1991-06-01

    The main points for 1991 Family Planning (FP) Work in China are discussed as follows: 1) strengthen leadership, 2) strengthen grass roots buildup, 3 intensify population plan management and improve the responsibility system, 4) strengthen publicity and promote population and FP education in rural areas, 5) strengthen and establish the legal system for FP management, 6) provide excellent contraceptive and birth control services, 7 perform inservice training conscientiously and technical secondary education earnestly, and 8) coordinate efforts among related departments. Leadership changes involve the 2 top leaders of the Communist Party Committees and governments at each level taking personal responsibility for the implementation of their local population plans and FP work. FP work must have a prominent place on all agendas. The FP service network needs to be accelerated in countries, townships, and villages and grass roots units strengthened in urban areas. Provinces, autonomous regions, and municipalities must work out their local population plans for 1991-95 and 1991-99 according to the national population target. Rational apportionment needs to be considered for prefectures and counties. The emphasis should be on timely and accurate feedback and statistical supervision. The 1990 national population census data should be used to inform everyone about the current population situation. Legal needs entail standardizing documentation and developing local laws and regulations within a comprehensive system. Improvements are needed in such areas as rules and regulations pertaining to the administration of charges for unplanned births, identification of disabled children and approval of the birth quota. Abortion and unplanned births are to be averted through prepregnancy management. The emphasis is on voluntary use of contraception by couples of childbearing age. Inservice training should improve the political, ideological, professional proficiency, and ability to

  1. Gas Main Sensor and Communications Network System

    Energy Technology Data Exchange (ETDEWEB)

    Hagen Schempf

    2006-05-31

    Automatika, Inc. was contracted by the Department of Energy (DOE) and with co-funding from the Northeast Gas Association (NGA), to develop an in-pipe natural gas prototype measurement and wireless communications system for assessing and monitoring distribution networks. This projected was completed in April 2006, and culminated in the installation of more than 2 dozen GasNet nodes in both low- and high-pressure cast-iron and steel mains owned by multiple utilities in the northeastern US. Utilities are currently logging data (off-line) and monitoring data in real time from single and multiple networked sensors over cellular networks and collecting data using wireless bluetooth PDA systems. The system was designed to be modular, using in-pipe sensor-wands capable of measuring, flow, pressure, temperature, water-content and vibration. Internal antennae allowed for the use of the pipe-internals as a waveguide for setting up a sensor network to collect data from multiple nodes simultaneously. Sensor nodes were designed to be installed with low- and no-blow techniques and tools. Using a multi-drop bus technique with a custom protocol, all electronics were designed to be buriable and allow for on-board data-collection (SD-card), wireless relaying and cellular network forwarding. Installation options afforded by the design included direct-burial and external polemounted variants. Power was provided by one or more batteries, direct AC-power (Class I Div.2) and solar-array. The utilities are currently in a data-collection phase and intend to use the collected (and processed) data to make capital improvement decisions, compare it to Stoner model predictions and evaluate the use of such a system for future expansion, technology-improvement and commercialization starting later in 2006.

  2. GAS MAIN SENSOR AND COMMUNICATIONS NETWORK SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Hagen Schempf

    2004-09-30

    Automatika, Inc. was contracted by the Department of Energy (DOE) and with co-funding from the New York Gas Group (NYGAS), to develop an in-pipe natural gas prototype measurement and wireless communications system for assessing and monitoring distribution networks. In Phase II of this three-phase program, an improved prototype system was built for low-pressure cast-iron and high-pressure steel (including a no-blow installation system) mains and tested in a serial-network configuration in a live network in Long Island with the support of Keyspan Energy, Inc. The experiment was carried out in several open-hole excavations over a multi-day period. The prototype units (3 total) combined sensors capable of monitoring pressure, flow, humidity, temperature and vibration, which were sampled and combined in data-packages in an in-pipe master-repeater-slave configuration in serial or ladder-network arrangements. It was verified that the system was capable of performing all data-sampling, data-storage and collection as expected, yielding interesting results as to flow-dynamics and vibration-detection. Wireless in-pipe communications were shown to be feasible and the system was demonstrated to run off in-ground battery- and above-ground solar power. The remote datalogger access and storage-card features were demonstrated and used to log and post-process system data. Real-time data-display on an updated Phase-I GUI was used for in-field demonstration and troubleshooting.

  3. Aqueous alteration on main-belt asteroids

    Science.gov (United States)

    Fornasier, S.; Lantz, C.; Barucci, M.; Lazzarin, M.

    2014-07-01

    The study of aqueous alteration is particularly important for unraveling the processes occurring during the earliest times in Solar System history, as it can give information both on the thermal processes and on the localization of water sources in the asteroid belt, and for the associated astrobiological implications. The aqueous alteration process produces the low temperature (< 320 K) chemical alteration of materials by liquid water which acts as a solvent and produces materials like phyllosilicates, sulphates, oxides, carbonates, and hydroxides. This means that liquid water was present in the primordial asteroids, produced by the melting of water ice by heating sources, very probably by ^{26}Al decay. Hydrated minerals have been found mainly on Mars surface, on primitive main-belt asteroids (C, G, B, F, and P-type, following the classification scheme by Tholen, 1984) and possibly also on few transneptunian objects. Reflectance spectroscopy of aqueous altered asteroids shows absorption features in the 0.6-0.9 and 2.5-3.5-micron regions, which are diagnostic of, or associated with, hydrated minerals. In this work, we investigate the aqueous alteration process on a large sample of 600 visible spectra of C-complex asteroids available in the literature. We analyzed all these spectra in a similar way to characterize the absorption-band parameters (band center, depth, and width) and spectral slope, and to look for possible correlations between the aqueous alteration process and the asteroids taxonomic classes, orbital elements, heliocentric distances, albedo, and sizes. We find that 4.6 % of P, 7.7 % of F, 9.8 % of B, 50.5 % of C, and 100 % of the G-type asteroids have absorption bands in the visible region due to hydrated silicates. Our analysis shows that the aqueous alteration sequence starts from the P-type objects, practically unaltered, and increases through the P → F → B → C → G asteroids, these last being widely aqueously altered, strengthening thus

  4. Description of the Main Features of the Series Production of the LHC Main Dipole Magnets

    CERN Document Server

    Savary, F; Chevret, P; de Rijk, G; Fessia, P; Liénard, P; Miles, J; Modena, M; Rossi, L; Tommasini, D; Vlogaert, J; Bresson, D; Grunblatt, G; Decoene, JF; Bressani, F; Drago, G; Gagliardi, P; Eysselein, F; Gärtner, W; Lublow, P

    2008-01-01

    The series production of the LHC main dipole magnets was completed in November 2006. This paper presents the organization implemented at CERN and the milestones fixed to fullfil the technical requirements and to respect the master schedule of the machine installation. The CERN organization for the production follow-up, the quality assurance and the magnet testing, as well as the organization of the three main contractors will be described. A description of the design work and procurement of most of the specific heavy tooling and key components will be given with emphasis on the advantages and drawbacks.

  5. DOE Zero Energy Ready Home Case Study: Near Zero Maine Home II - Vassalboro, Maine

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-11-01

    This case study describes a DOE Zero Energy Ready home in Vassalboro, Maine, that scored HERS 35 without PV and HERS 11 with PV. This 1,200 ft2 home has 10.5-inch-thick double-walls with 3 layers of mineral wool batt insulation, an R-20 insulated slab, R-70 cellulose in the attic, extensive air sealing, a mini-split heat pump, an heat recovery ventilator, solar water heating, LED lighting, 3.9 kWh PV, and triple-pane windows.

  6. 30 CFR 75.519 - Main power circuits; disconnecting switches.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main power circuits; disconnecting switches. 75... § 75.519 Main power circuits; disconnecting switches. In all main power circuits, disconnecting... which main power circuits enter the underground area of the mine and within 500 feet of all other...

  7. A Maine romance. [Solar heating, wind power and cliff erosion control at a Maine site

    Energy Technology Data Exchange (ETDEWEB)

    Adams, J.A.

    1979-09-01

    The construction of a house on the coast of Maine included terracing of the bluff for erosion control, installation of water solar collectors for space and water heating, and construction of a wind turbine for electric power generation. A total of 4,027 ft/sup 2/ of house area is heated by a system of 10 collectors and 4,000 gal water storage. Insulation values are R-19 in the walls, R-40 in the ceiling, R-26 in the floors, and R-14 in the basement. South-facing windows provide additional heat gain. The wind turbine and generator system supplies alternating current to the house and also heats auxiliary water storage when necessary. The house, collectors, and wind turbine are designed to supply 85% of the heating load.

  8. 33 CFR 334.10 - Gulf of Maine off Seal Island, Maine; naval aircraft bombing target area.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Maine off Seal Island, Maine; naval aircraft bombing target area. 334.10 Section 334.10 Navigation and Navigable Waters CORPS... REGULATIONS § 334.10 Gulf of Maine off Seal Island, Maine; naval aircraft bombing target area. (a) The danger...

  9. 76 FR 32266 - Maine Northern Railway Company-Trackage Rights Exemption-Montreal, Maine & Atlantic Railway, Ltd.

    Science.gov (United States)

    2011-06-03

    ... Surface Transportation Board Maine Northern Railway Company--Trackage Rights Exemption-- Montreal, Maine & Atlantic Railway, Ltd. Pursuant to a written trackage rights agreement, Montreal, Maine & Atlantic Railway, Ltd. (MMA) has agreed to grant overhead trackage rights to the Maine Northern Railway Company (MNRC...

  10. 76 FR 32265 - Maine Northern Railway Company-Trackage Rights Exemption-Montreal, Maine & Atlantic Railway, Ltd.

    Science.gov (United States)

    2011-06-03

    ... Surface Transportation Board Maine Northern Railway Company--Trackage Rights Exemption-- Montreal, Maine & Atlantic Railway, Ltd. Pursuant to a written trackage rights agreement, Montreal, Maine & Atlantic Railway, Ltd. (MMA) has agreed to grant overhead trackage rights to the Maine Northern Railway Company (MNRC...

  11. 14 CFR 27.751 - Main float buoyancy.

    Science.gov (United States)

    2010-01-01

    ... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Floats and Hulls § 27.751 Main float buoyancy. (a) For main floats, the buoyancy necessary to support the maximum weight of the rotorcraft in...

  12. 14 CFR 29.751 - Main float buoyancy.

    Science.gov (United States)

    2010-01-01

    ... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Floats and Hulls § 29.751 Main float buoyancy. (a) For main floats, the buoyancy necessary to support the maximum weight of the rotorcraft...

  13. [Introduction to qualitative research: the main approaches and designs].

    Science.gov (United States)

    Ambrosi, Elisa; Canzan, Federica

    2013-01-01

    Introduction to qualitative research: the main approaches and designs. The main methods (phenomenology, ethnography, Grounded, narrative enquiry and case studies) and sampling technique of qualitative research are briefly outlined. A practical example is presented for each method.

  14. Space Shuttle Main Propulsion System Anomaly Detection: A Case Study

    Data.gov (United States)

    National Aeronautics and Space Administration — The space shuttle main engine (SSME) is part of the Main Propnlsion System (MPS) which is an extremely complex system containing several sub-systems and components,...

  15. 46 CFR 182.610 - Main steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Main steering gear. 182.610 Section 182.610 Shipping...) MACHINERY INSTALLATION Steering Systems § 182.610 Main steering gear. (a) A vessel must be provided with a main steering gear that is: (1) Of adequate strength and capable of steering the vessel at all...

  16. 46 CFR 109.333 - Fire main cutoff valves.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Fire main cutoff valves. 109.333 Section 109.333... OPERATIONS Operation and Stowage of Safety Equipment § 109.333 Fire main cutoff valves. The master or person in charge shall insure that each fire main cutoff valve is open and sealed to prevent closing,...

  17. Synthesis of main-chain metal carbonyl organometallic macromolecules (MCMCOMs).

    Science.gov (United States)

    Cao, Kai; Murshid, Nimer; Wang, Xiaosong

    2015-04-01

    Synthesis of main-chain metal carbonyl organometallic macromolecules (MCMCOMs) is difficult, mainly due to the instability of metal carbonyl complexes. Despite its challenge a number of MCMCOMs has been prepared by strategically using organometallic, organic, and polymer synthetic chemistry. Main contributions to this research field were reported by the groups of Tyler, Pannell, and Wang and are briefly summarized in this article.

  18. 14 CFR 23.753 - Main float design.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main float design. 23.753 Section 23.753... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Floats and Hulls § 23.753 Main float design. Each seaplane main float must meet the requirements of § 23.521. ...

  19. Tallinna maine ja Ülemiste vanake / Maimu Berg

    Index Scriptorium Estoniae

    Berg, Maimu, 1945-

    2002-01-01

    Tallinna maine tõstmist tuleb alustada konkreetse tööga, mitte abstraktsete projektide väljamõtlemisega. Ilmunud ka kogumikus: Berg, Maimu. Tants lahkunud isaga. Tallinn : Kirilille Kirjastus, 2003, lk. 90-92, pealk. Linna tavaline maine. Linnar Priimäe juhitavast Tallinna maine kujundamise projektist

  20. 14 CFR 27.547 - Main rotor structure.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main rotor structure. 27.547 Section 27.547 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Strength Requirements Main Component Requirements § 27.547 Main rotor...

  1. 46 CFR 108.419 - Fire main capacity.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Fire main capacity. 108.419 Section 108.419 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Fire Extinguishing Systems Fire Main System § 108.419 Fire main capacity. The diameter of the...

  2. Tallinna maine ja Ülemiste vanake / Maimu Berg

    Index Scriptorium Estoniae

    Berg, Maimu, 1945-

    2002-01-01

    Tallinna maine tõstmist tuleb alustada konkreetse tööga, mitte abstraktsete projektide väljamõtlemisega. Ilmunud ka kogumikus: Berg, Maimu. Tants lahkunud isaga. Tallinn : Kirilille Kirjastus, 2003, lk. 90-92, pealk. Linna tavaline maine. Linnar Priimäe juhitavast Tallinna maine kujundamise projektist

  3. 46 CFR 58.01-35 - Main propulsion auxiliary machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Main propulsion auxiliary machinery. 58.01-35 Section 58... AUXILIARY MACHINERY AND RELATED SYSTEMS General Requirements § 58.01-35 Main propulsion auxiliary machinery. Auxiliary machinery vital to the main propulsion system must be provided in duplicate unless the...

  4. 14 CFR 119.47 - Maintaining a principal base of operations, main operations base, and main maintenance base...

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Maintaining a principal base of operations, main operations base, and main maintenance base; change of address. 119.47 Section 119.47 Aeronautics... operations base, and main maintenance base; change of address. (a) Each certificate holder must maintain...

  5. Organizational Communication: An Analysis of the Main Perspectives, Main Concepts and Future Directions of the Field

    Directory of Open Access Journals (Sweden)

    Yusuf Yüksel

    2013-09-01

    Full Text Available There is a scholarly debate since the 1980s regarding the content, theory, methodology and applications that define the scope of organizational communication and separate it from other related disciplines. This debate is critical in the sense that it enables to identity organizational communication in a rich manner and helps us define the scope of the field and its unique characteristics. Based on this main assumption, this study addressed the major theoretical/methodological dimensions of the field (functional, interpretive, and critical, conceptualization of the most critical concepts (organization, communication, culture, voice/control in these dimensions, and current gaps and future directions of the field. This study revealed that the field of organizational communication has made great improvements since the field emerged in the last three decade with its own content, methodology, and applications and generated an adequate body of research within these different perspectives. It is shown that representation of the field by different perspectives provides richness to the field compared with the time when organizational communication was solely dominated by functional, positivist research. Key words: Functional/interpretive/critical perspectives, communication, organization, culture, control, effectiveness. Örgütsel İletişim: Alanın Ana Yaklaşımları, Ana Kavramları ve Gelecek Yönelimlerinin AnaliziÖzÖrgütsel iletişim alanının kapsamı ve bu alanı ilgili displinlerden ayıracak içerik, teori, yöntem, ve uygulamalar üzerine akademik tartışmalar 1980’li yıllardan beri devam etmektedir. Bu tartışmalar, örgütsel iletişim alanının derinlemesine anlaşılması, sınırlarının belirlenmesi ve diğer disiplinlerden ayrılan özelliklerinin anlaşılması noktasında hayati öneme sahiptir. Bu temel varsayımdan hareketle, bu çalışma alandaki temel teorik/yöntemsel yaklaşımları (işlevsel, yorumlayıcı, ele

  6. Maine StreamStats: a water-resources web application

    Science.gov (United States)

    Lombard, Pamela J.

    2015-01-01

    Maine StreamStats is a tool that any user with Internet access can use to delineate a basin on the fly and estimate a wide variety of streamflow statistics for ungaged sites on rivers and streams in Maine. Estimates are based on regression equations or are from data from similar gaged locations on the stream. Maine StreamStats is based on a national StreamStats application that can be used for streamflow estimates in many other states across the country.

  7. Post-Main Sequence Evolution of Debris Discs

    OpenAIRE

    Bonsor, Amy; Wyatt, Mark

    2010-01-01

    The population of debris discs on the main sequence is well constrained, however very little is known about debris discs around evolved stars. In this work we provide a theoretical framework that considers the effects of stellar evolution on debris discs; firstly considering the evolution of an individual disc from the main sequence through to the white dwarf phase, then extending this to the known population of debris discs around main sequence A stars. It is found that discs around evolved ...

  8. 33 CFR 127.607 - Fire main systems.

    Science.gov (United States)

    2010-07-01

    ...) WATERFRONT FACILITIES WATERFRONT FACILITIES HANDLING LIQUEFIED NATURAL GAS AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Natural Gas Firefighting § 127.607 Fire main systems. (a)...

  9. Some nonlinear parameters of PP intervals of pulse main peaks

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The PP intervals of pulse main peaks from healthy and unhealthy people (arrhythmia) have different nonlinear characteristics. In this paper, the extraction of PP intervals of pulse main peaks is achieved by picking up P peaks of pulse wave with wavelet transform. Furthermore, several nonlinear parameters (correlative dimensions, maximum Lyapunov exponents, complexity and approximate entropy) of the PP intervals of pulse main peaks extracted from normal and unhealthy pulse signals are calculated, with the results showing that these nonlinear parameters calculated from the main wave interval signals are helpful for analyzing human's health state and diagnosing heart diseases.

  10. Analysis of thermoelastohydrodynamic performance of journal misaligned engine main bearings

    Science.gov (United States)

    Bi, Fengrong; Shao, Kang; Liu, Changwen; Wang, Xia; Zhang, Jian

    2015-05-01

    To understand the engine main bearings' working condition is important in order to improve the performance of engine. However, thermal effects and thermal effect deformations of engine main bearings are rarely considered simultaneously in most studies. A typical finite element model is selected and the effect of thermoelastohydrodynamic(TEHD) reaction on engine main bearings is investigated. The calculated method of main bearing's thermal hydrodynamic reaction and journal misalignment effect is finite difference method, and its deformation reaction is calculated by using finite element method. The oil film pressure is solved numerically with Reynolds boundary conditions when various bearing characteristics are calculated. The whole model considers a temperature-pressure-viscosity relationship for the lubricant, surface roughness effect, and also an angular misalignment between the journal and the bearing. Numerical simulations of operation of a typical I6 diesel engine main bearing is conducted and importance of several contributing factors in mixed lubrication is discussed. The performance characteristics of journal misaligned main bearings under elastohydrodynamic(EHD) and TEHD loads of an I6 diesel engine are received, and then the journal center orbit movement, minimum oil film thickness and maximum oil film pressure of main bearings are estimated over a wide range of engine operation. The model is verified through the comparison with other present models. The TEHD performance of engine main bearings with various effects under the influences of journal misalignment is revealed, this is helpful to understand EHD and TEHD effect of misaligned engine main bearings.

  11. Intravascular ultrasound for angiographically indeterminant left main coronary artery disease.

    Science.gov (United States)

    Parashara, D K; Jacobs, L E; Ledley, G S; Yazdanfar, S; Oline, J; Kotler, M N

    1994-01-01

    The precise diagnosis of the presence of significant left main coronary artery disease has profound prognostic and therapeutic implications. Coronary cineangiography has shown to be imprecise and inaccurate to determine the percent stenosis of the left main coronary artery. We report a case with significant left main coronary artery disease in whom coronary cineangiography was in discordance with the clinical data and intravascular ultrasonography. Based on the intravascular ultrasound findings, the patient underwent coronary artery bypass graft surgery. Therefore, the intravascular ultrasonography may be the procedure of choice for assessing indeterminant left main coronary artery lesions by coronary angiography.

  12. STRUCTURE AND STABILITY OF MAIN ROOF AFTER ITS FRACTURE

    Institute of Scientific and Technical Information of China (English)

    朱德仁; 钱鸣高

    1990-01-01

    A serics of physical modelings in which a main roof is considered as a Kirchhoff plate supported or clammed by Winkler elastic foundation were performed to simulate the fracturing process of the main roof in longwall mining. Based on these modelings spatial structures of the main roof after its fracture are described, blocks of the fractured main roof are classified and their behaviors are analyzed in this paper. Additionally, two stability indexes of the structures are defined, and the factors affecting stability of the structures with different boundaries and geometric conditions are discussed.

  13. Main data - RMG | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...ftp://ftp.biosciencedbc.jp/archive/rmg/LATEST/rmg_main.zip File size: 1 KB Simple search URL http://togodb.b... This Database Database Description Download License Update History of This Database Site Policy | Contact Us Main data - RMG | LSDB Archive ...

  14. Main - KOME | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...ntents List of datasets Data file File name: kome_main.zip File URL: ftp://ftp.biosciencedbc.jp/archive/kome...ase Database Description Download License Update History of This Database Site Policy | Contact Us Main - KOME | LSDB Archive ...

  15. PRISMA/DB: A Parallel Main-Memory Relational DBMS

    NARCIS (Netherlands)

    Apers, Peter M.G.; Flokstra, Jan; van den Berg, Carel A.; Grefen, P.W.P.J.; Wilschut, A.N.; Kersten, Martin L.; van den Berg, C.A.

    1992-01-01

    PRISMA/DB, a full-fledged parallel, main memory relational database management system (DBMS) is described. PRISMA/DB's high performance is obtained by the use of parallelism for query processing and main memory storage of the entire database. A flexible architecture for experimenting with functional

  16. 46 CFR 28.850 - Main source of electrical power.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Main source of electrical power. 28.850 Section 28.850... FISHING INDUSTRY VESSELS Aleutian Trade Act Vessels § 28.850 Main source of electrical power. (a) Applicability: Each vessel that relies on electricity to power any of the following essential loads must have at...

  17. 46 CFR 28.355 - Main source of electrical power.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Main source of electrical power. 28.355 Section 28.355... Operate With More Than 16 Individuals on Board § 28.355 Main source of electrical power. (a) Applicability. Each vessel that relies on electricity to power any of the following essential loads must have at least...

  18. Bicyclic graphs with exactly two main signless Laplacian eigenvalues

    CERN Document Server

    Huang, He

    2012-01-01

    A signless Laplacian eigenvalue of a graph $G$ is called a main signless Laplacian eigenvalue if it has an eigenvector the sum of whose entries is not equal to zero. In this paper, all connected bicyclic graphs with exactly two main eigenvalues are determined.

  19. 14 CFR 27.753 - Main float design.

    Science.gov (United States)

    2010-01-01

    ... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Floats and Hulls § 27.753 Main float design. (a) Bag floats. Each bag float must be designed to withstand— (1) The maximum pressure differential... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main float design. 27.753 Section...

  20. 14 CFR 29.753 - Main float design.

    Science.gov (United States)

    2010-01-01

    ... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Floats and Hulls § 29.753 Main float design. (a) Bag floats. Each bag float must be designed to withstand— (1) The maximum pressure differential... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main float design. 29.753 Section...

  1. DETERMINING SMALL AND MEDIUM INDUSTRY MAIN PRODUCT IN BANYUMAS DISTRICT

    Directory of Open Access Journals (Sweden)

    Muhammad Unggul Abdul Fattah

    2016-01-01

    Full Text Available The purpose of this study was to determine the main product out of several alternative options of small and medium industries (IKM main product in Banyumas District. The study was conducted by using in-depth interviews with respondents who were skillful experts with the authority to establish the main product in Banyumas. The criteria used in determining the main product come from 12 criteria set out in the Regulation of the Ministry of Home Affairs of Republic of Indonesia Number 9 of 2014. The establishment of criteria values was determined by using AHP and main product assessment with MPE. The results of the assessment indicate that the first priority of main product Banyumas is the coconut sugar. Coconut sugar products are supported by the abundance of natural resources of raw materials, while the other main product priorities include mendoan tempeh and getuk gerbong which are typical products of Banyumas. Both products are products that will facilitate economic growth through tourism as a specific sector for culinary products of Banyumas.Keywords: main product, small and medium industries (IKM, AHP, MPE

  2. Main Idea Comprehension: Training Teachers and Effects on Students.

    Science.gov (United States)

    Carriedo, N.; Alonso-Tapia, J.

    1996-01-01

    Investigates the effectiveness of main idea identification training by teachers who had been successfully trained in such identification. Finds that the experimental group of students (in grades six, seven, and eight) performed better than the control group on main idea identification and knowledge of strategies related to that process. Discusses…

  3. Economic and Occupational Aspects of Recent Inmigration to Maine.

    Science.gov (United States)

    Ploch, Louis A.

    Inmigration to Maine was found to have altered population distribution, increased the proportion of younger, highly educated persons, and provided a pool of professional/managerial persons for community involvement. Data gathered from 417 persons moving into Maine during the July through December period of either 1980 or 1983 showed inmigrants to…

  4. Velocity Estimation of the Main Portal Vein with Transverse Oscillation

    DEFF Research Database (Denmark)

    Brandt, Andreas Hjelm; Hansen, Kristoffer Lindskov; Nielsen, Michael Bachmann

    2015-01-01

    This study evaluates if Transverse Oscillation (TO) can provide reliable and accurate peak velocity estimates of blood flow the main portal vein. TO was evaluated against the recommended and most widely used technique for portal flow estimation, Spectral Doppler Ultrasound (SDU). The main portal...

  5. 14 CFR 25.753 - Main float design.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main float design. 25.753 Section 25.753 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Floats and Hulls § 25.753 Main float design...

  6. Completion of Main Magnet Fabrication for CYCIAE-100

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The main magnet of CYCIAE-100, which weighs roughly 416 tons after machining, is mainly consisting of 4 pairs of sector magnets, 4 return yokes, top/bottom yoke, central plug, and shimming bars. It falls into the category of large-scale high precision device,

  7. Main - PLACE | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us ...URL: ftp://ftp.biosciencedbc.jp/archive/place/LATEST/place_main.zip File size: 48...97) Joomla SEF URLs by Artio About This Database Database Description Download License Update History of This Database Site Policy | Contact Us Main - PLACE | LSDB Archive ...

  8. 14 CFR 29.547 - Main and tail rotor structure.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main and tail rotor structure. 29.547 Section 29.547 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Requirements § 29.547 Main and tail rotor structure. (a) A rotor is an assembly of rotating components, which...

  9. Velocity Estimation of the Main Portal Vein with Transverse Oscillation

    DEFF Research Database (Denmark)

    Brandt, Andreas Hjelm; Hansen, Kristoffer Lindskov; Nielsen, Michael Bachmann;

    2015-01-01

    This study evaluates if Transverse Oscillation (TO) can provide reliable and accurate peak velocity estimates of blood flow the main portal vein. TO was evaluated against the recommended and most widely used technique for portal flow estimation, Spectral Doppler Ultrasound (SDU). The main portal ...

  10. Main-duct intraductal papillary mucinous adenoma of the pancreas

    Directory of Open Access Journals (Sweden)

    Takuma Kensuke

    2011-11-01

    Full Text Available Abstract Background The prevalence of carcinoma in main-duct intraductal papillary mucinous neoplasm (IPMN is high, and surgical resection is recommended for all patients with a main-duct IPMN. Results A main-duct IPMN with typical imagings including protruding lesions in the dilated main pancreatic duct was resected, but the histology was intraductal papillary mucinous adenoma of the pancreas. Discussion It has been reported that the presence of mural nodules and dilatation of MPD are significantly higher in malignant IPMNs. The presented case had protruding lesions in the dilated main pancreatic duct on endoscopic ultrasonography, but the histology was adenoma. Conclusion Preoperative distinction between benign and malignant IPMNs is difficult.

  11. IDENTIFICATION OF MAIN ECONOMIC AND SOCIAL CAUSES OF ROMANIAN MIGRATION

    Directory of Open Access Journals (Sweden)

    Elena Raluca CRISTIAN

    2015-07-01

    Full Text Available The main worldwide determinants influencing in time the migration phenomenon are: external environment (international political situation, economy, population growth in the migrant’s country, armed conflicts, religious persecution and xenophobic attacks. The migration of manpower from Romania is based on a number of psychological, social, financial reasons of migrants to increase their income and improve their living conditions in another country. The main cause of migration in developed countries is the migration flows originating mainly from poor or very poor countries considered disadvantaged.

  12. Heat Transfer in the LHC Main Superconducting Bus Bars

    CERN Document Server

    Granieri, P P; Richter, D

    2011-01-01

    CERN is performing a systematic analysis of the interconnecting bus bars of the Large Hadron Collider (LHC) main magnets. Their thermal, electrical, mechanical and hydraulic performances are addressed. In the frame of these studies, the heat transfer between the main superconducting (SC) bus bars and the surrounding He bath is investigated. It represents a key parameter in the comprehension of the bus bars stability and quench propagation mechanisms, thus crucial for the analysis of the 2008 incident which was triggered by a defective bus bars joint. This paper reports on the experimental tests and relative analysis aiming at describing the thermal behavior of the LHC main bus bars.

  13. Contaminant assessment of common terns in the Gulf of Maine

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In 2001, developmental abnormalities and low productivity were reported in common tern (Sterna hirundo) chicks from three islands on the Maine coast - Stratton...

  14. Mercury assessment of Brandy Pond T39 MD, Maine

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Brandy Pond is a remote, shallow, pond in east‐central Maine. A bald eagle (Haliaeetus leucocephalus) nest territory has existed on the pond since the mid-1960s....

  15. Annual Narrative Maine Coastal Islands National Wildlife Refuge Complex 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Maine Coastal Islands National Wildlife Refuge outlines Refuge accomplishments during the 1994 calendar year. The report begins with...

  16. Coastal Maine Submerged Aquatic Vegetation Data 1993-1997 Geodatabase

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Maine's eelgrass (SAV) meadows form an important aquatic habitat for the state. These meadows provide shelter for juvenile fish, and invertebrates. In certain...

  17. Coastal Maine Submerged Aquatic Vegetation Data 1993-1997 Biotic

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Maine's eelgrass (SAV) meadows form an important aquatic habitat for the state. These meadows provide shelter for juvenile fish, and invertebrates. In certain...

  18. Assistant pullback technique for main span closure of Sutong Bridge

    Institute of Scientific and Technical Information of China (English)

    Chen Ming; Luo Chengbin; Wu Qihe; Zhang Yongtao; You Xinpeng

    2009-01-01

    Sutong Bridge is a cable-stayed steel box girder bridge with a main span of 1 088 m. The erection of upper structure adopts geometry control method and requires no change to the unit's size and the structure's none-stress geometry. Before main span closure, the cantilever of girder reaches 540.8 m, the structure state is noticeably influenced by external circumstances, the main span closure face great difficulty. By abstracting the advantage of the pullback method abroad and the domestic temperature-cutting method, a new assistant pullback method have put forward and bring into practice actually. In this paper, the analysis key point of practice conditions, key parameter of practice, main measures of the method and the performance is introduced.

  19. Gulf of Maine Cooperative Bottom Longline Survey Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This database is for a bottom longline (fixed gear) survey executed in the western and central Gulf of Maine targeting complex rocky habitats. The survey is operated...

  20. Coastal Maine Submerged Aquatic Vegetation Data 1993-1997 Substrate

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Maine's eelgrass (SAV) meadows form an important aquatic habitat for the state. These meadows provide shelter for juvenile fish, and invertebrates. In certain...

  1. Analysis of Carol's Paradoxical Characters in Main Street

    Institute of Scientific and Technical Information of China (English)

    赵红璐; 高冰

    2010-01-01

    @@ 1. Introduction to Sinclair Lewis and Main Street Sinclair Lewis (1885-1951) is regarded as one of the foremost American satirists in the early twentieth century. He cared for books more than sports and felt limited by his rural hometown. In 1925, he rejected the Pulitzer Prize for Arrowsmith because he felt that he deserved the prize for Main Street. In 1930, he became the first American who won the Nobel Prize for Literature. Lewis was a novelist who was interested in many different aspects of American society, from business and medicine to small town life. His works were famous for insightful and critical views of the society and capitalist values. Lewis' s Main Street is considered to be his first success and his favorite work which is written in a dark tone. Main Street was published in 1920, which became a runaway bestseller.

  2. Social Justice as the Main Task of a State

    Directory of Open Access Journals (Sweden)

    Slatenkova Mariia O.

    2013-11-01

    Full Text Available Social justice always was and will be as the most significant indicator of efficiency of social development of the society being one of the fundamental grounds of the civilisation and progress. The goal of the article is justification of a necessity of application of the principle of social justice in practice of the state regulation for creation of favourable conditions of development of the society. The article considers one of the main functions of a state – social, directed at the socio-political harmonisation of social relations; justifies objective necessity of interference of the state with the problem of restoration of justice in the society. The main instrument of this interference is active social policy of the state oriented at problems of the whole population. Main instruments that regulate social relations are main spheres of the society, such as political, economic and social. Finding a balance among these social spheres would facilitate the nation’s well-being.

  3. Beam dynamics at the main LEBT of RAON accelerator

    CERN Document Server

    Jin, Hyunchang

    2015-01-01

    The high-intensity rare-isotope accelerator (RAON) of the Rare Isotope Science Project (RISP) in Daejeon, Korea, has been designed to accelerate multiple-charge-state beams. The ion beams, which are generated by Electron Cyclotron Resonance Ion Source (ECR-IS), will be transported through the main Low Energy Beam Transport (LEBT) system to the Radio Frequency Quadrupole (RFQ). While passing the beams through LEBT, we should keep the transverse beam size and longitudinal emittance small. Furthermore, the matching of required twiss parameter at the RFQ entrance will be performed by using electro-static quadrupoles at the main LEBT matching section which is from the multi-harmonic buncher (MHB) to the entrance of RFQ. We will briefly review the new aspects of main LEBT lattice and the beam matching at the main LEBT matching section will be presented. In addition, the effects of various errors on the beam orbit and the correction of distorted orbit will be discussed.

  4. CONDITIONS AND MAIN CRITERIA OF ENSURING FOOD SECURITY

    Directory of Open Access Journals (Sweden)

    Mikhailushkin P. V.

    2013-10-01

    Full Text Available The article considers the main components, factors and criteria of ensuring food security of the modern state. Need of state regulation of economy as a whole and its food subcomplex in particular has been designated

  5. Maine & the Maritimes: Waterfowl breeding population survey: 2000

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the Waterfowl Breeding Population and Habitat Survey for Maine and the Maritimes during 2000. The primary purpose of the survey is to provide...

  6. The advanced main control console for next japanese PWR plants

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchiya, A. [Hokkaido Electric Power Co., Inc., Sapporo (Japan); Ito, K. [Mitsubishi Heavy Industries, Ltd., Nuclear Energy Systems Engineering Center, Yokohama (Japan); Yokoyama, M. [Mitsubishi Electric Corporation, Energy and Industrial Systems Center, Kobe (Japan)

    2001-07-01

    The purpose of the improvement of main control room designing in a nuclear power plant is to reduce operators' workload and potential human errors by offering a better working environment where operators can maximize their abilities. In order to satisfy such requirements, the design of main control board applied to Japanese Pressurized Water Reactor (PWR) type nuclear power plant has been continuously modified and improved. the Japanese Pressurized Water Reactor (PWR) Utilities (Electric Power Companies) and Mitsubishi Group have developed an advanced main control board (console) reflecting on the study of human factors, as well as using a state of the art electronics technology. In this report, we would like to introduce the configuration and features of the Advanced Main Control Console for the practical application to the next generation PWR type nuclear power plants including TOMARI No.3 Unit of Hokkaido Electric Power Co., Inc. (author)

  7. Gridded bathymetry of Kohala, Hawaii, Main Hawaiian Islands, USA.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — 5-m grid of bathymetric data of Kohala coast of Hawaii, Main Hawaiian Islands, USA. The ASCII grids include multibeam bathymetry from the Reson 8101 multibeam sonar...

  8. Main Detector of Cosmic Rays at Yangbajing Fully Operational

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The construction of the main detector of the Astroparticle-physics Research at Ground-based Observatory Yangbajing (Yangbajain) Experiment (dubbed the YBJ-ARGO Experiment) has been completed and put into full operation recently.

  9. Water Stratification Raster Images for the Gulf of Maine

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This geodatabase contains seasonal water stratification raster images for the Gulf of Maine. They were created by interpolating water density (sigma t) values at 0...

  10. Coastal Maine National Wildlife Refuge Narrative report : Jan. - Dec. 1966

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Coastal Maine National Wildlife Refuge outlines Refuge accomplishments during the 1966 calendar year. The report begins by...

  11. Liver Contaminants in Bald eagles Carcasses from Maine

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Fifty-one livers were extracted from bald eagle carcasses recovered in Maine between 2001 and 2007. Approximately 50% of the birds were collected during the spring...

  12. Gulf of Maine Contaminated Sediments Database (GOMCSDB shapefile)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Contaminated Sediments Database for the Gulf of Maine provides a compilation and synthesis of existing data to help establish the environmental status of our...

  13. Cassini Main Engine Assembly Cover Flight Management and Performance

    Science.gov (United States)

    Somawardhana, Ruwan P.; Millard, Jerry M.

    2010-01-01

    The Cassini spacecraft has performed its four year Prime Mission at Saturn and is currently in orbit at Saturn performing a two year extended mission. 12Its main engine nozzles are susceptible to impact damage from micrometeoroids and on-orbit dust. The spacecraft has an articulating device known as the Main Engine Assembly (MEA) cover which can close and shield the main engines from these threats. The cover opens to allow for main engine burns that are necessary to maintain the trajectory. Periodically updated analyses of potential on-orbit dust hazard threats have resulted in the need to continue to use the MEA cover beyond its intended use and beyond its design life. This paper provides a detailed Systems-level overview of the flight management of the MEA cover device and its flight performance to date.

  14. Regional Ocean Modeling System (ROMS): Main Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 7-day, 3-hourly forecast for the region surrounding the main Hawaiian islands at approximately 4-km resolution. While...

  15. Main - AT Atlas | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data List Contact us AT Atlas... Database Description Download License Update History of This Database Site Policy | Contact Us Main - AT Atlas | LSDB Archive ...

  16. Main - TP Atlas | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data List Contact us TP Atlas...d License Update History of This Database Site Policy | Contact Us Main - TP Atlas | LSDB Archive ...

  17. Where is the main source of Jupiter family comets situated?

    CERN Document Server

    Kazantsev, A M

    2012-01-01

    An attempt to determine spatial location of the main source of short-period comet nuclei was made. There were carried out numerical calculations for orbit evolution of Jupiter family comets, comets with middle-period orbits and bodies of Centaur group. On the basis of the calculations it was shown, that orbital evolution of the solar system small bodies is mainly going in the direction of the semi-major axes increase. It belongs to the bodies which can undergo approaches the planets, and orbital evolution of which is mainly going due to the gravitational forces. Such result is confirmed by qualitative analysis of changes of small body semi-major axes under approaches the planets. The conclusion was drawn that the main source of nuclei of Jupiter family comets is apparently situated at distances from the Sun not more than 6 AU.

  18. Main - RPSD | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data List Contact us RPSD...nse Update History of This Database Site Policy | Contact Us Main - RPSD | LSDB Archive ...

  19. Water Density Raster Images for the Gulf of Maine

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This geodatabase contains water density raster images for the Gulf of Maine that were interpolated from water density (sigma t or kilograms/ meters cubed) point data...

  20. Maine Coastal Islands National Wildlife Refuge: Final Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Maine Coastal Islands National Wildlife Refuge for the next 15 years. This plan...

  1. Portland, Maine Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Portland, Maine Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST) model. MOST...

  2. Regional Ocean Modeling System (ROMS): Main Hawaiian Islands: Data Assimilating

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Regional Ocean Modeling System (ROMS) 3-day, 3-hourly data assimilating hindcast for the region surrounding the main Hawaiian islands at approximately 4-km...

  3. 5m Main Belt Asteroid Population Estimation Using Vesta Imagery

    Science.gov (United States)

    Rynders, Michael; Trilling, David E.

    2016-10-01

    The Main Belt is the largest source of Near-Earth asteroids, but objects 2 pixels in diameter that were counted in a 33km 2 region to give a crater density. By knowing the crater density and making some reasonable assumptions about the orbital distribution of asteroids and the age of Vesta's surface, an estimate of the population of small asteroids in the inner main belt was made. It was found that the inner region of the main asteroid belt contains approximately 20 billion asteroids larger than 5 m. These results agree well with the measured inner Main Belt Size distribution derived by the Wide-field Infrared Survey Explorer, WISE (Masiero et al. 2011).

  4. Post-Main Sequence Evolution of Debris Discs

    CERN Document Server

    Bonsor, Amy

    2010-01-01

    The population of debris discs on the main sequence is well constrained, however very little is known about debris discs around evolved stars. In this work we provide a theoretical framework that considers the effects of stellar evolution on debris discs; firstly considering the evolution of an individual disc from the main sequence through to the white dwarf phase, then extending this to the known population of debris discs around main sequence A stars. It is found that discs around evolved stars are harder to detect than on the main sequence. In the context of our models discs should be detectable with Herschel or Alma on the giant branch, subject to the uncertain effect of sublimation on the discs. The best chances are for hot young white dwarfs, fitting nicely with the observations e.g the helix nebula (Su et al. 2007) and 9 systems presented by Chu & Bilikova.

  5. Main sequence masses and radii from gravitational redshifts

    CERN Document Server

    Von Hippel, T

    1995-01-01

    Modern instrumentation makes it possible to measure the mass to radius ratio for main sequence stars in open clusters from gravitational redshifts. For stars where independent information is available for either the mass or the radius, this application of general relativity directly determines the other quantity. Applicable examples are: 1) measuring the radii of solar metallicity main sequence stars for which the mass - luminosity relation is well known, 2) measuring the radii for stars where model atmospheres can be used to determine the surface gravity (the mass to radius squared ratio), 3) refining the mass - radius relation for main sequence stars, and 4) measuring the change in radius as stars evolve off the main sequence and up the giant branch.

  6. Lithium Depletion in Fully Convective Pre-Main Sequence Stars

    CERN Document Server

    Bildsten, L; Matzner, C D; Ushomirsky, G; Bildsten, Lars; Brown, Edward F.; Matzner, Christopher D.; Ushomirsky, Greg

    1996-01-01

    We present an analytic calculation of the thermonuclear depletion of lithium in contracting, fully convective, pre-main sequence stars of mass M 0.08 M_sun) and for constraining the masses of lithium depleted stars.

  7. RECURSIVE CONVEYOR PROCESSES - THE MAIN PROPERTIES AND CHARACTERISTICS

    Directory of Open Access Journals (Sweden)

    Boris V. Kupriyanov

    2015-01-01

    Full Text Available In the article the formal model of recursive conveyor processes is considered. The main properties and characteristics ofthis type of processes are described andillustrated. Based on these properties splitting processes into classes is carried out.

  8. Narrative report calendar year 1968 : Coastal Maine National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Coastal Maine National Wildlife Refuge outlines Refuge accomplishments during the 1968 calendar year. The report begins by...

  9. Coastal Maine Submerged Aquatic Vegetation Data 1993-1997 Geoform

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Maine's eelgrass (SAV) meadows form an important aquatic habitat for the state. These meadows provide shelter for juvenile fish, and invertebrates. In certain...

  10. Annual Narrative Maine Coastal Islands National Wildlife Refuge Complex 1996

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Maine Coastal Islands Refuge Complex outlines Refuge accomplishments during the 1996 calendar year. The report begins with a summary...

  11. Mercury levels in seabirds in the Gulf of Maine

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — We conducted a pilot study to screen mercury (Hg) levels in Gulf of Maine seabirds in an effort to determine which species are most at risk, are the most appropriate...

  12. NVRAM as Main Storage of Parallel File System

    OpenAIRE

    MALINOWSKI Artur

    2016-01-01

    Modern cluster environments' main trouble used to be lack of computational power provided by CPUs and GPUs, but recently they suffer more and more from insufficient performance of input and output operations. Apart from better network infrastructure and more sophisticated processing algorithms, a lot of solutions base on emerging memory technologies. This paper presents evaluation of using non-volatile random-access memory as a main storage of Parallel File System. The author justifies fea...

  13. Open innovation systems: main characteristics and trends of internationalization

    OpenAIRE

    2016-01-01

    Exploring the peculiarities and trends in innovation development in modern conditions is based on defining its new characteristics caused by postindustrial transformations. The aim of writing this article is to study the main elements of open national innovation systems and trends of their integration into international innovation cooperation. In the course of performing the set tasks, we used methods of system and structural–functional analysis to substantiate the main components of open...

  14. FUZZY CONTROLLED AUTOMATION SYSTEM FOR THE MAIN COAL BUNKER

    Institute of Scientific and Technical Information of China (English)

    邵良杉; 叶景楼; 付华

    1997-01-01

    A fuzzy control scheme is presented according to the coal quantity in the main coal bunker, this method has a good dynamic response characteristic and is suited for complex nonlinear systems. The designation of self-adopting fuzzy controller, the working principle and functions of this system are also proposed, with the hardware and the main flow diagram of this system introduced in this paper.

  15. Main stages of development of photodynamic therapy in Russia

    Directory of Open Access Journals (Sweden)

    E. F. Stranadko

    2015-01-01

    Full Text Available The main stages of development and establishment of photodynamic therapy (PDT in Russia are described in the article. Brief description of photosensitizers approved for clinical use in Russia including fotogem, photosens, alasens, radachlorine and fotoditazin is represented. Their physical and chemical and spectral characteristics, drug formulations, results of pre-clinical studies and post-marketing experience are shown. Main research centers dealing with PDT are listed. 

  16. Improvement of Main Magnetic Field Power Supply of SFC

    Institute of Scientific and Technical Information of China (English)

    ZhangXianlai; YanHuaihai; XinJunye; ZhangShu

    2003-01-01

    The main magnetic field power supply is used for establishing main magnetic field of SFC, therefore excellent current stability and low ripple are required. Its DC output current range is 0~1300 A and max output voltage is 230 V. The power supply has been put into operation since Sep. in 2000, and was replaced in 033 room from 166 room of No.2 Building. We have improved the performance of power supply in this period.

  17. An Electromagnetic Interference Problem via the Mains Distribution Networks

    Directory of Open Access Journals (Sweden)

    BUZDUGAN, M. I.

    2007-11-01

    Full Text Available The paper presents an electromagnetic interference problem, due to the proximity of two radio broadcasting stations which injected especially common mode conducted emissions over the maximal limits specified by the national regulations in the public low voltage mains network. These emissions determined the malfunction of the gas heating centrals Themaclassic Saunier Duval installed in the area. The problem was solved by the retro fitting of an extra EMI filter for the mains network, as presented in the paper.

  18. Design of MGA trajectories for main belt asteroid

    Institute of Scientific and Technical Information of China (English)

    崔祜涛; 乔栋; 崔平远; 栾恩杰

    2003-01-01

    Asteroid exploration is one of the most sophisticated missions currently being investigated. Gravityassist trajectories have proven valuable in interplanetary missions such as the Pioneer, Voyager and Galileo. In this paper, we design interplanetary trajectory for main belt asteroid exploration mission with the Mars gravityassist (MGA) using "pork chop" plots and patched-conic theory and give some initial valuable trajectory parameters on main belt asteroid exploration mission with MGA.

  19. Main stages of development of photodynamic therapy in Russia

    OpenAIRE

    E. F. Stranadko

    2015-01-01

    The main stages of development and establishment of photodynamic therapy (PDT) in Russia are described in the article. Brief description of photosensitizers approved for clinical use in Russia including fotogem, photosens, alasens, radachlorine and fotoditazin is represented. Their physical and chemical and spectral characteristics, drug formulations, results of pre-clinical studies and post-marketing experience are shown. Main research centers dealing with PDT are listed. 

  20. Sediment exchange between groin fields and main-stream

    Science.gov (United States)

    Qin, Jie; Zhong, Deyu; Wu, Teng; Wu, Lingli

    2017-10-01

    Sediment exchange between groin fields and the main-stream influences the transport and distribution of polluted sediment that represents a hazard for rivers and neighboring floodplains. Despite its practical significance, little research has been done on the sediment exchange process itself, and existing studies used to estimate the sediment exchange by morphological change. The sediment exchange process, however, differs from morphological variation and includes two behaviors: the entrance of main-stream sediment into groin fields and the movement of groin field sediment out of groin fields. Therefore, this study aims at examining this exchange process and exploring the mechanisms of different exchange phenomena. Experiments were conducted in a mobile-bed laboratory flume by using a novel experimental method that successfully separates the movement of groin fields sediment from that of main-stream sediment. In addition to traditional measurements, such as measurements of morphological changes, surface flow velocities, and bed-form propagation, the deposition of main-stream sediment in groin fields is measured in detail. The results demonstrate that morphological change cannot reflect the sediment exchange process. The deposition of main-stream sediment in groin fields is determined by the dynamics of sediment movement, in which bedload- and suspended-sediment-dominated processes exhibit different deposition patterns. The movement of groin field sediment out of groin fields is determined mainly by local scouring around groins.

  1. Assigning Main Orientation to an EOH Descriptor on Multispectral Images

    Directory of Open Access Journals (Sweden)

    Yong Li

    2015-07-01

    Full Text Available This paper proposes an approach to compute an EOH (edge-oriented histogram descriptor with main orientation. EOH has a better matching ability than SIFT (scale-invariant feature transform on multispectral images, but does not assign a main orientation to keypoints. Alternatively, it tends to assign the same main orientation to every keypoint, e.g., zero degrees. This limits EOH to matching keypoints between images of translation misalignment only. Observing this limitation, we propose assigning to keypoints the main orientation that is computed with PIIFD (partial intensity invariant feature descriptor. In the proposed method, SIFT keypoints are detected from images as the extrema of difference of Gaussians, and every keypoint is assigned to the main orientation computed with PIIFD. Then, EOH is computed for every keypoint with respect to its main orientation. In addition, an implementation variant is proposed for fast computation of the EOH descriptor. Experimental results show that the proposed approach performs more robustly than the original EOH on image pairs that have a rotation misalignment.

  2. Are pre-main-sequence stars older than we thought?

    CERN Document Server

    Naylor, Tim

    2009-01-01

    We fit the colour-magnitude diagrams of stars between the zero-age main-sequence and terminal-age main sequence in young clusters and associations. The ages we derive are a factor 1.5 to 2 longer than the commonly used ages for these regions, which are derived from the positions of pre-main-sequence stars in colour-magnitude diagrams. From an examination of the uncertainties in the main-sequence and pre-main-sequence models, we conclude that the longer age scale is probably the correct one, which implies we must revise upwards the commonly used ages for young clusters and associations. Such a revision would explain the discrepancy between the observational lifetimes of proto-planetary discs and theoretical calculations of the time to form planets. It would also explain the absence of clusters with ages between 5 and 30Myr. We use the $\\tau^2$ statistic to fit the main-sequence data, but find that we must make significant modifications if we are to fit sequences which have vertical segments in the colour-magni...

  3. Assigning Main Orientation to an EOH Descriptor on Multispectral Images.

    Science.gov (United States)

    Li, Yong; Shi, Xiang; Wei, Lijun; Zou, Junwei; Chen, Fang

    2015-07-01

    This paper proposes an approach to compute an EOH (edge-oriented histogram) descriptor with main orientation. EOH has a better matching ability than SIFT (scale-invariant feature transform) on multispectral images, but does not assign a main orientation to keypoints. Alternatively, it tends to assign the same main orientation to every keypoint, e.g., zero degrees. This limits EOH to matching keypoints between images of translation misalignment only. Observing this limitation, we propose assigning to keypoints the main orientation that is computed with PIIFD (partial intensity invariant feature descriptor). In the proposed method, SIFT keypoints are detected from images as the extrema of difference of Gaussians, and every keypoint is assigned to the main orientation computed with PIIFD. Then, EOH is computed for every keypoint with respect to its main orientation. In addition, an implementation variant is proposed for fast computation of the EOH descriptor. Experimental results show that the proposed approach performs more robustly than the original EOH on image pairs that have a rotation misalignment.

  4. Determination of Main Noise Sources in a Thermal Power plant

    Directory of Open Access Journals (Sweden)

    M. Jahangiri

    2014-09-01

    Full Text Available Introduction: The Power plants are as the major industries that have a large number of workers, providing they health is important. Exposure to occupational noise is the pervasive physical agent in industries like power plants and may impact health and for safety status for people. Determination of the sources of noise in workplaces is important step in noise control plans. This study aimed to assess noise pollution and determine the main sources of noise in a power plant for. .Material and Method: This descriptive cross-sectional study was conducted on the ground floor of the turbine unit of a thermal power plant. Measurements was done based on the ISO-9612 and ISO-11200 standard using by the calibrated sound level meter model TES-1389 on “A” frequency weighting and “Slow” mode for time response. Surfer V.10 software was used for interpolation and noise maps producing. Based on grid method measuring for indicating of noise propagation, we set buffer of danger areas to determine main sources of noise. Also, we used the minimized grid method for measuring and study of noise denotation in vertical surface in each main sources. .Result: The results showed that the measured indoor sound pressure level in all areas where at the risk category of the units. The highest average sound pressure level was belonged to the unit 2, with 93.1 dB(A. We find the feed water pumps were the main sources in all of the studied units. Among the four main components of the main sources, the highest noise levels associated with the main pump and the gearbox section with about 100 9B(L and dominant frequency of 2000 Hz. .Conclusion: Considering that feed water pumps had major sources in indoor power plant noise pollution, engineering noise control such as providing enclosures is necessary to reduce noise pollution to safe levels in the studied plant it is necessary.

  5. THE HABITABLE ZONES OF PRE-MAIN-SEQUENCE STARS

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, Ramses M.; Kaltenegger, Lisa [Institute for Pale Blue Dots, Cornell University, Ithaca, NY (United States)

    2014-12-20

    We calculate the pre-main-sequence habitable zone (HZ) for stars of spectral classes F-M. The spatial distribution of liquid water and its change during the pre-main-sequence phase of protoplanetary systems is important for understanding how planets become habitable. Such worlds are interesting targets for future missions because the coolest stars could provide habitable conditions for up to 2.5 billion years post-accretion. Moreover, for a given star type, planetary systems are more easily resolved because of higher pre-main-sequence stellar luminosities, resulting in larger planet-star separation for cool stars than is the case for the traditional main-sequence (MS) HZ. We use one-dimensional radiative-convective climate and stellar evolutionary models to calculate pre-main-sequence HZ distances for F1-M8 stellar types. We also show that accreting planets that are later located in the traditional MS HZ orbiting stars cooler than a K5 (including the full range of M stars) receive stellar fluxes that exceed the runaway greenhouse threshold, and thus may lose substantial amounts of water initially delivered to them. We predict that M-star planets need to initially accrete more water than Earth did, or, alternatively, have additional water delivered later during the long pre-MS phase to remain habitable. Our findings are also consistent with recent claims that Venus lost its water during accretion.

  6. The Habitable Zones of Pre-Main-Sequence Stars

    CERN Document Server

    Ramirez, Ramses M

    2014-01-01

    We calculate the pre-main-sequence HZ for stars of spectral classes F to M. The spatial distribution of liquid water and its change during the pre-main-sequence phase of protoplanetary systems is important in understanding how planets become habitable. Such worlds are interesting targets for future missions because the coolest stars could provide habitable conditions for up to 2.5 billion years post-accretion. Moreover, for a given star type, planetary systems are more easily resolved because of higher pre-main-sequence stellar luminosities, resulting in larger planet to star separation for cool stars than is the case for the traditional main-sequence (MS) habitable zone (HZ). We use 1D radiative-convective climate and stellar evolutionary models to calculate pre-main-sequence HZ distances for F1 to M8 stellar types. We also show that accreting planets that are later located in the traditional MS HZ orbiting stars cooler than a K5 (including the full range of M-stars) receive stellar fluxes that exceed the ru...

  7. Crack widths in concrete with fibers and main reinforcement

    DEFF Research Database (Denmark)

    Christensen, Frede; Ulfkjær, Jens Peder; Brincker, Rune

    the ductility of the fiber reinforced concrete (FRC) is set up and experimental work is conducted in order to verify the crack width model. The ductility of the FRC is taken into account by using the stress crack width relation. The constitutive model for the FRC is based on the idea that the initial part......The main object of the research work presented in this paper is to establish design tools for concrete structures where main reinforcement is combined with addition of short discrete steel fibers. The work is concerned with calculating and measuring crack widths in structural elements subjected...... to bending load. Thus, the aim of the work is to enable engineers to calculate crack widths for flexural concrete members and analyze how different combinations of amounts of fibers and amounts of main reinforcement can meet a given maximum crack width requirement. A mathematical model including...

  8. Forecasting large aftershocks within one day after the main shock.

    Science.gov (United States)

    Omi, Takahiro; Ogata, Yosihiko; Hirata, Yoshito; Aihara, Kazuyuki

    2013-01-01

    Forecasting the aftershock probability has been performed by the authorities to mitigate hazards in the disaster area after a main shock. However, despite the fact that most of large aftershocks occur within a day from the main shock, the operational forecasting has been very difficult during this time-period due to incomplete recording of early aftershocks. Here we propose a real-time method for efficiently forecasting the occurrence rates of potential aftershocks using systematically incomplete observations that are available in a few hours after the main shocks. We demonstrate the method's utility by retrospective early forecasting of the aftershock activity of the 2011 Tohoku-Oki Earthquake of M9.0 in Japan. Furthermore, we compare the results by the real-time data with the compiled preliminary data to examine robustness of the present method for the aftershocks of a recent inland earthquake in Japan.

  9. Mass arsenic poisoning and the public health response in Maine.

    Science.gov (United States)

    Mills, Dora A; Tomassoni, Anthony J; Tallon, Lindsay A; Kade, Kristy A; Savoia, Elena S

    2013-06-01

    Created in the wake of the September 11, 2001 terrorist attacks, Maine's Office of Public Health Emergency Preparedness within the Maine Center for Disease Control and Prevention undertook a major reorganization of epidemiology and laboratory services and began developing relationships with key partners and stakeholders, and a knowledgeable and skilled public health emergency preparedness workforce. In 2003, these newly implemented initiatives were tested extensively during a mass arsenic poisoning at the Gustav Adolph Lutheran Church in the rural northern community of New Sweden, Maine. This episode serves as a prominent marker of how increased preparedness capabilities, as demonstrated by the rapid identification and administration of antidotes and effective collaborations between key partners, can contribute to the management of broader public health emergencies in rural areas.

  10. Design and Testing of CPAS Main Deployment Bag Energy Modulator

    Science.gov (United States)

    Mollmann, Catherine

    2017-01-01

    During the developmental testing program for CPAS (Capsule Parachute Assembly System), the parachute system for the NASA Orion Crew Module, simulation revealed that high loads may be experienced by the pilot risers during the most devere deployment conditions. As the role of the pilot parachutes is to deploy the main parachutes, these high loads introduced the possibility of main deployment failure. In order to mitigate these high loads, a set of energy modulators was incorporated between the pilot riser and the main deployment bag. An extensive developmental program was implemented to ensure the adequacy of these energy modulators. After initial design comparisons, the energy modulator design was validated through slow-speed joint tests as well as through high-speed bungee tests. This paper documents the design, development, and results of multiple tests completed on the final design.

  11. The Star-Forming Main Sequence at Low Galaxy Mass

    Science.gov (United States)

    Stierwalt, Sabrina; Johnson, Kelsey E.; Patton, David R.; Besla, Gurtina; Kallivayalil, Nitya; Liss, Sandra; Pearson, Sarah; Privon, George C.; Putman, Mary E.

    2017-01-01

    We present an investigation of the star-forming main sequence at the low mass end. The relation between galaxy stellar mass and star formation rate has been well-studied in the recent literature for a range of redshifts and galaxy type, but almost all of these studies are limited to galaxies with stellar masses above the dwarf galaxy range ( 109 Msun ). Our work, based on the panchromatic TiNy Titans survey of interacting dwarf galaxies, shows that dwarf galaxies extend the well-established main sequence at z=0 down to lower masses. Furthermore, like their more massive counterparts, dwarf mergers appear on an elevated main sequence with higher star formation rates for a given stellar mass. Finally we show that star formation is enhanced to a greater extent in low mass galaxy mergers than for higher mass systems.

  12. Status Report on the LHC Main Magnet Production

    CERN Document Server

    de Rijk, G; Cornelis, M; Durante, M; Fessia, P; Miles, J; Modena, M; Molinari, G; Rinn, J; Savary, F; Schirm, K; Simon, F; Tommasini, D; Tortschanoff, Theodor; Vlogaert, J; Applied Superconductivity Conference (ASC/04)

    2005-01-01

    The LHC ring will contain 1232 main dipole and 382 main quadrupole twin aperture magnets. All main magnets are superconducting and employ NbTi/Cu Rutherford type cables operated at 1.9 K. The dipole production has reached the equivalent of almost three octants of cold masses and nearly four octants of collared coils. The quadrupole production has reached 75 cold masses and over 150 bare magnets. The ramping up of large scale magnet production has posed several challenges which will be discussed, like: the coil size uniformity, coil pre-stress control, cold mass welding technique and the geometrical shape issues. The magnetic measurement results at warm will be presented together with their usage for the quality control in the production. The common features and differences of the three dipole producers will be discussed. Finally the latest version of the production schedule will be presented.

  13. Posterior fossa malformations: main features and limits in prenatal diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Garel, Catherine [Hopital d' Enfants Armand-Trousseau, Department of Radiology, Paris (France)

    2010-06-15

    Posterior fossa (PF) malformations are commonly observed during prenatal screening. Their understanding requires knowledge of the main steps of PF development and knowledge of normal patterns in US and MR imaging. The vast majority of PF malformations can be strongly suspected by acquiring a midline sagittal slice and a transverse slice and by systematically scrutinizing the elements of the PF: cerebellar vermis, hemispheres, brainstem, fourth ventricle, PF fluid spaces and tentorium. Analysis of cerebellar echogenicity and biometry is also useful. This review explains how to approach the diagnosis of the main PF malformations by performing these two slices and answering six key questions about the elements of the PF. The main imaging characteristics of PF malformations are also reviewed. (orig.)

  14. THE INFLUENCE OF NUTRITION ON THE MAIN PRODUCTION OF BROCCOLI

    Directory of Open Access Journals (Sweden)

    Mădălina Doltu

    2013-07-01

    Full Text Available The research was realized in the unheated greenhouse of Horting Institute Bucharest, in 2012 year. It have aimed the influence of one phase of fertilization with ammonium nitrate (NH4NO3 on inflorescences of broccoli, at a hybrid F1 - Ironman. The fertilizer was used before the formation of main inflorescences, in different doses (100 kg/ha, 150 kg/ha, without fertilizer. Harvesting was done in 4 stages. A phase of fertilization with ammonium nitrate has influenced the main production of broccoli: the variant with fertilization 150 kg/ha has obtained the highest percentage of inflorescences formed, the average weight/inflorescence largest and superior production compared with other variants. Were obtained direct linear correlations between the doses of ammonium nitrate (NH4NO3 and the production aspects followed (percentage of main inflorescences harvested, average weight/inflorescence, total production, significances of the correlations very high.

  15. A mobile Magnetic Sensor Unit for the KATRIN Main Spectrometer

    CERN Document Server

    Osipowicz, A; Letnev, J; Marte, P; Müller, A; Spengler, A; Unru, A; 10.1088/1748-0221/7/06/T06002

    2012-01-01

    The KArlsruhe TRItium Neutrino experiment (KATRIN) aims to measure the electron neutrino mass with an unprecedented sensitivity of 0.2 eV/c2, using b decay electrons from tritium decay. For the control of magnetic field in the main spectrometer area of the KATRIN experiment a mobile magnetic sensor unit is constructed and tested at the KATRIN main spectrometer site. The unit moves on inner rails of the support structures of the low field shaping coils which are arranged along the the main spectrometer. The unit propagates on a caterpillar drive and contains an electro motor, battery pack, board electronics, 2 triaxial flux gate sensors and 2 inclination senors. During operation all relevant data are stored on board and transmitted to the master station after the docking station is reached.

  16. Detector level ABI spectral response function: FM4 analysis and comparison for different ABI modules

    Science.gov (United States)

    Efremova, Boryana; Pearlman, Aaron J.; Padula, Frank; Wu, Xiangqian

    2016-09-01

    A new generation of imaging instruments Advanced Baseline Imager (ABI) is to be launched aboard the Geostationary Operational Environmental Satellites - R Series (GOES-R). Four ABI flight modules (FM) are planned to be launched on GOES-R,S,T,U, the first one in the fall of 2016. Pre-launch testing is on-going for FM3 and FM4. ABI has 16 spectral channels, six in the visible/near infrared (VNIR 0.47 - 2.25 μm), and ten in the thermal infrared (TIR 3.9 - 13.3 μm) spectral regions, to be calibrated on-orbit by observing respectively a solar diffuser and a blackbody. Each channel has hundreds of detectors arranged in columns. Operationally one Analytic Generation of Spectral Response (ANGEN) function will be used to represent the spectral response function (SRF) of all detectors in a band. The Vendor conducted prelaunch end-to-end SRF testing to compare to ANGEN; detector specific SRF data was taken for: i) best detector selected (BDS) mode - for FM 2,3, and 4; and ii) all detectors (column mode) - for four spectral bands in FM3 and FM4. The GOES-R calibration working group (CWG) has independently used the SRF test data for FM2 and FM3 to study the potential impact of detector-to-detector SRF differences on the ABI detected Earth view radiances. In this paper we expand the CWG analysis to include the FM4 SRF test data - the results are in agreement with the Vendor analysis, and show excellent instrument performance and compare the detector-to-detector SRF differences and their potential impact on the detected Earth view radiances for all of the tested ABI modules.

  17. Photometry and Lightcurve Analysis of 7 Main-Belt Asteroids

    Science.gov (United States)

    Violante, Renata; Leake, M. A.

    2013-01-01

    We report the synodic periods and lightcurves for three main-belt asteroids and provide lightcurves for four other main-belt asteroids. 676 Melitta has a period of 8.35 ± 0.05 hours, with an amplitude of 0.056 ± 0.026 magnitude; 688 Melanie has a period of 16.10 ± 0.05 hours, and an amplitude of 0.091 ± 0.019 magnitude; 1677 Tycho Brahe has a period of 3.89 ± 0.06 hours, and an amplitude of 0.564 ± 0.011 magnitude.

  18. THE INFLUENCE OF NUTRITION ON THE MAIN PRODUCTION OF BROCCOLI

    OpenAIRE

    Mădălina Doltu; Marian Bogoescu; Dorin Sora

    2013-01-01

    The research was realized in the unheated greenhouse of Horting Institute Bucharest, in 2012 year. It have aimed the influence of one phase of fertilization with ammonium nitrate (NH4NO3) on inflorescences of broccoli, at a hybrid F1 - Ironman. The fertilizer was used before the formation of main inflorescences, in different doses (100 kg/ha, 150 kg/ha, without fertilizer). Harvesting was done in 4 stages. A phase of fertilization with ammonium nitrate has influenced the main production of br...

  19. The Evaluation of Main Methods and Approaches in Language Teaching

    Institute of Scientific and Technical Information of China (English)

    夏欣

    2008-01-01

    Language teaching has a long,fascinating,but rather tortuous history.(Stern,1984) For over a century,there have been.many methods and approaches in language teaching.This article is mainly focused on three methods and approaches:the Grammar-translation Method;the Direct Method and Audio-lingual Approach and the Com-municative Approach.First We will define"method"and"approach",and then we will focus on the main character-istics.advantages and limitations of each method or approach.

  20. Operational Safety Analysis of CEFR Main Feed Pump

    Institute of Scientific and Technical Information of China (English)

    DING; Tong-wei; ZHANG; Huan-qi

    2012-01-01

    <正>China Experimental Fast Reactor (CEFR) use three main feed pumps, two parallel running and one standby at full power. During CEFR operation, the pressure of deaerator is maintained at (1.16±0.01) MPa. Combined with the actual condition of the single feed pump carried out the NPSH analysis of full flow range calculation, the results are listed in Table 1. The actual measured mounting height of feed water pump is -19.2 m. The analysis results that the main feed pumps running condition cavitation does not

  1. A Spectroscopically Unique Main Belt Asteroid: 10537 (1991 RY16)

    CERN Document Server

    Moskovitz, Nicholas A; Jedicke, Robert; Willman, Mark; Haghighipour, Nader; Bus, Schelte J; Gaidos, Eric

    2008-01-01

    We present visible and near-infrared reflectance spectra and interpreted surface mineralogy for asteroid 10537 (1991 RY16). The spectrum of this object is without precedent amongst the Main Belt asteroids. A unique absorption band centered at 0.63 microns could be attributed to one of several mineralogies. Pronounced 1- and 2-micron absorption bands suggest that the composition of 10537 is a mixture of pyroxenes and olivine and that it originated from a parent body that was partially or fully differentiated. The closest available analog is the large Main Belt asteroid 349 Dembowska but 10537 may be an isolated fragment from a completely eroded parent body.

  2. Lateral groundwater inflows into alluvial aquifers of main alpine valleys

    Science.gov (United States)

    Burger, Ulrich

    2015-04-01

    In alpine regions the topography is mainly characterised by deep incised valleys, mountain slopes and ridges. Usually the main valleys contain aquifers in alluvial soft rock. Lateral these aquifers are confined by mountainous hard rock slopes covered by heterogeneous sediments with different thickness. The slopes can be incised by lateral valleys. Numerical models for the main alluvial aquifers ask for lateral hydrogeological boundaries. Usually no flow boundaries or Constant head Boundaries are used, even if the lateral inflows to the main aquifers are rarely known. In this example a data set for a detailed investigated and monitored area is studied to give an answer on the location and the quantification of these lateral subsurface inflows. The study area is a typical main alpine valley with a thick alluvial aquifer (appr. 120m thick), lateral confined by granite, covered at the base of the steep slopes by quaternary sediments (Burger at al. 2012). The study consists of several steps 1.) Analytical calculation of the inflows on the base of investigated and monitored 2d profiles along fault zones (Perello et al 2013) which pinch out in the main valley 2.) Analytical models along typical W-dipping slopes with monitored slope springs 3.) Evaluating temperature and electrical conductivity profiles measured in approx. 30 groundwater wells in the alluvial aquifers and along the slopes to locate main lateral subsurface inflows 4.) Output of a regional model used for the hydrogeological back analyses of the excavation of a tunnel (Baietto et al. 2014) 5.) Output of a local numerical model calibrated with a monitoring dataset and results of a pumping test of big scale (450l/s for 10days) Results of these analyses are shown to locate and quantify the lateral groundwater inflows in the main alluvial aquifer. References Baietto A., Burger U., Perello P. (2014): Hydrogeological modelling applications in tunnel excavations: examples from tunnel excavations in granitic rocks

  3. Installation management for the European XFEL main accelerator

    Science.gov (United States)

    Bousonville, M.; Eints, F.; Choroba, S.

    2017-07-01

    By end of 2016, the main accelerator of the European XFEL was completed. To build this complex machine in a minimum of time, certain management methods were introduced in mid 2015, which accelerated the installation process substantially. In the following 64 weeks additional 84 % of the main accelerator were set up. This was possible due to an improved planning, the reinforcement of two teams as well as a permanent controlling and optimizing of the installation process. In this paper, the installation process from July 2015 to end 2016 and the measures, which speeded up the workflow, are described.

  4. The Main Obstacles to Improve English Reading Speed

    Institute of Scientific and Technical Information of China (English)

    YANG Yu-rong

    2016-01-01

    With the globalization of economy, English has become a universal language, which makes learning of English increas-ingly important in many non-English-speaking countries. In order to learn the language well, reading should be attached ade-quate importance. Reading ability, as a basic requirement in learning a foreign language, can be developed by doing comprehen-sion exercises. The key to improve reading lies in reading speed. The faster you read, the more you are able to grasp the main point of a text. However, many people have obstacles in reading. This paper summarizes the main barriers in reading fast and puts forward some strategies for improving reading speed.

  5. Active Asteroids: Main-Belt Comets and Disrupted Asteroids

    CERN Document Server

    Hsieh, Henry H

    2015-01-01

    The study of active asteroids has attracted a great deal of interest in recent years since the recognition of main-belt comets (which orbit in the main asteroid belt, but exhibit comet-like activity due to the sublimation of volatile ices) as a new class of comets in 2006, and the discovery of the first disrupted asteroids (which, unlike MBCs, exhibit comet-like activity due to a physical disruption such as an impact or rotational destabilization, not sublimation) in 2010. In this paper, I will briefly discuss key areas of interest in the study of active asteroids.

  6. Cache-Conscious Index Mechanism for Main-Memory Databases

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Recent studies have addressed that the cache behavior is important in the design of main memory index structures. Cache-conscious indices such as the CSB+-tree are shown to outperform conventional main memory indices such as the AVL-tree and the T-tree. This paper proposes a cache-conscious version of the T-tree, CST-tree, defined according to the cache-conscious definition. To separate the keys within a node into two parts, the CST-tree can gain higher cache hit ratio.

  7. [Analysis of main chemical composition in hydrogenated rosin from Zhuzhou].

    Science.gov (United States)

    Duan, W G; Chen, X P; Wang, L L; Deng, S; Zhou, Y H; An, X N

    2001-01-01

    The acid fraction, the main part of the hydrogenated rosin produced by Zhuzhou Forest Chemicals Plant of China, was separated from neutral fraction by modified DEAE-Sephadex ion exchange chromatography and analyzed with GC-MS-DS technique by using DB-5 capillary column. Six dihydroabietic-type resin acids, four dihydropimaric/isopimaric-type resin acids and four tetrahydroabietic-type resin acids were identified. The hydrogenated rosin is composed mainly of 8-abietenoic acid, 18-abietanoic acid, 13-abietenoic acid, 8 alpha, 13 beta-abietanoic acid, 13 beta-8-abietenoic acid and 8-isopimarenoic acid etc.

  8. [The Main Military Hospital during the Great Patriotic War].

    Science.gov (United States)

    Maksimov, I B; Kozakov, S P; Ovchinnikova, M B

    2010-04-01

    Was characterized activity of the Central Military Clinical Hospital by Burdenko N.N. during the Great Patriotic War. From the first days work of the hospital was reorganized in dependence of needs of war time. More then 50% of physicians went in army, leading specialists were established main surgeons and therapeutics of fronts and armies. During the war efforts of collective were aimed on the main purpose--return life and health to the biggest number of patients, and the hospital pulled off this mission. During the war were treated more then 74 000 of ill and wounded persons, 82% of them were returned in troops.

  9. A successful team treatment for left main shock syndrome

    Institute of Scientific and Technical Information of China (English)

    Bin Que; Yu-Tong Cheng; Hai Gao; Xiao-Tong Hou; Ran Dong; Nan Li; Shao-Ping Nie

    2013-01-01

    Acute myocardial infarction complicated by cardiogenic shock and left main coronary artery disease is called left main shock syndrome. It is reported that the morbility and mortality of the syndrome is approximately 0.46%and 55%-80%, respectively. However, the best treat-ment strategy in these cases is unknown. In this article, we present a patient with LMSS who successively underwent emergency percutane-ous coronary intervention and coronary artery bypass grafting with hemodynamic support within 5 days. The patient is now on his three month uneventful out-patient follow-up.

  10. The Main Problems and Countermeasures of English Classroom Talk

    Directory of Open Access Journals (Sweden)

    Qian Bojie

    2015-01-01

    Full Text Available English classroom talk is one of the effective media for knowledge transfer in the English classroom, and how to use it effectively is a problem worth discussing. This article summarizes the main problems of English classroom talk through the analysis of its characteristics, and finally puts forward targeted counter-measures.

  11. Progress of Research on Demonstration Fast Reactor Main Pipe Material

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The main characteristics of the sodium pipe system in demonstration fast reactor are high-temperature, thin-wall and big-caliber, which is different from the high-pressure and thick-wall of the pressurized water reactor system, and the system is long-term

  12. The truncated Second Main Theorem and uniqueness theorems

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper, we first establish a truncated Second Main Theorem for algebraically nondegenerate holomorphic mappings from the complex plane into a complex projective variety V intersecting hypersurfaces. We then prove some uniqueness results for meromorphic mappings. The result of Demailly about a partial solution to the Fujita’s conjecture is used.

  13. Strategies for Abstracting Main Ideas from Simple Technical Prose.

    Science.gov (United States)

    1981-11-11

    Dijk (1979), and Perfetti and Goldman (1974, 1975) has focused on specific Page 4 aspects of how the topic or main idea of a passage is marked or...490. Perfetti , C. A., & Goldman, S. R. Thematization and sentence retrieval. Journal of Verbal Learning and Verbal Behavior, 1974, 13, 70-79. Perfetti

  14. The worldwide use of computers : a description of main trends

    NARCIS (Netherlands)

    Pelgrum, W.J.; Plomp, T.

    1993-01-01

    This paper examines some of the main findings from the IEA Computers in Education survey. The results show that with respect to the future of computers in education there is reason for optimism as well as for pessimism. The optimistic part of the story is that new technologies in the form of

  15. Transesophageal echocardiography assessment of severe ostial left main coronary stenosis

    Science.gov (United States)

    Firstenberg, M. S.; Greenberg, N. L.; Lin, S. S.; Garcia, M. J.; Alexander, L. A.; Thomas, J. D.

    2000-01-01

    Doppler echocardiography is commonly used in the assessment of stenotic valvular orifices. We describe the application of transesophageal echocardiography for the detection of a critical ostial left main coronary stenosis. Because preoperative coronary angiography often is not routinely performed in young patients undergoing valve surgery, application of Doppler echocardiography can potentially prevent catastrophic complications, particularly in atypical cases.

  16. An outbreak of bucephalosis in fish of the Main river.

    Science.gov (United States)

    Hoffmann, R W; Körting, W; Fischer-Scherl, T; Schäfer, W

    1990-05-01

    High losses due to metacercaria of Bucephalus polymorphus especially in cyprinids were observed in summer 1984 during a period of a sudden increase in water temperature. Pathology of diseased fish is described. Factors, such as eutrophication of the water system and overcrowding of distinct fish species, are discussed to be the main causes provoking outbreak of the parasitosis.

  17. Impact of Dynamic Magnetic fields on the CLIC Main Beam

    CERN Document Server

    Snuverink, J; Jach, C; Jeanneret, JB; Schulte, D; Stulle, F

    2010-01-01

    The Compact Linear Collider (CLIC) accelerator has strong precision requirements on the position of the beam. The beam position will be sensitive to external dynamic magnetic fields (stray fields) in the nanotesla regime. The impact of these fields on the CLIC main beam has been studied by performing simulations on the lattices and tolerances have been determined. Several mitigation techniques will be discussed.

  18. Circumstellar Material on and off the Main Sequence

    Science.gov (United States)

    Steele, Amy; Debes, John H.; Deming, Drake

    2017-06-01

    There is evidence of circumstellar material around main sequence, giant, and white dwarf stars that originates from the small-body population of planetary systems. These bodies tell us something about the chemistry and evolution of protoplanetary disks and the planetary systems they form. What happens to this material as its host star evolves off the main sequence, and how does that inform our understanding of the typical chemistry of rocky bodies in planetary systems? In this talk, I will discuss the composition(s) of circumstellar material on and off the main sequence to begin to answer the question, “Is Earth normal?” In particular, I look at three types of debris disks to understand the typical chemistry of planetary systems—young debris disks, debris disks around giant stars, and dust around white dwarfs. I will review the current understanding on how to infer dust composition for each class of disk, and present new work on constraining dust composition from infrared excesses around main sequence and giant stars. Finally, dusty and polluted white dwarfs hold a unique key to our understanding of the composition of rocky bodies around other stars. In particular, I will discuss WD1145+017, which has a transiting, disintegrating planetesimal. I will review what we know about this system through high speed photometry and spectroscopy and present new work on understanding the complex interplay of physics that creates white dwarf pollution from the disintegration of rocky bodies.

  19. Desmin heterogeneity in the main electric organ of Electrophorus electricus.

    Science.gov (United States)

    Costa, M L; Moura Neto, V; Chagas, C

    1988-06-01

    Desmin, the muscle-specific intermediate filament protein was purified from the main electric organ of Electrophorus electricus. It is shown that pure desmin can be separated into 5 isoforms presenting different isoelectric points. These isoforms have similar molecular weight, react with an antibody directed against desmin and generate identical peptides after digestion with protease V8 from Staphylococcus aureus.

  20. Dependence of the aftershock flow on the main shock magnitude

    Science.gov (United States)

    Guglielmi, A. V.; Zavyalov, A. D.; Zotov, O. D.; Lavrov, I. P.

    2017-01-01

    Previously, we predicted and then observed in practice the property of aftershocks which consists in the statistically regular clustering of events in time during the first hours after the main shock. The characteristic quasi-period of clustering is three hours. This property is associated with the cumulative action of the surface waves converging to the epicenter, whereas the quasi-period is mainly determined by the time delay of the round-the-world seismic echo. The quasi-period varies from case to case. In the attempt to find the cause of this variability, we have statistically explored the probable dependence of quasi-period on the magnitude of the main shock. In this paper, we present the corresponding result of analyzing global seismicity from the USGS/NEIC earthquake catalog. We succeeded in finding a significant reduction in the quasiperiod of the strong earthquakes clustering with growth in the magnitude of the main shock. We suggest the interpretation of this regularity from the standpoint of the phenomenological theory of explosive instability. It is noted that the phenomenon of explosive instability is fairly common in the geophysical media. The examples of explosive instability in the radiation belt and magnetospheric tail are presented. The search for the parallels in the evolution of explosive instability in the lithosphere and magnetosphere of the Earth will enrich both the physics of the earthquakes and physics of the magnetospheric pulsations.

  1. The certified Maine North Woods, where money grows from trees

    NARCIS (Netherlands)

    Correia, David

    Beginning in the 1990s, private ownership in Maine forestland shifted from a number of corporate owners to a patchwork of timber investment management organizations (TIMOs) and real estate investment trusts (REITs). This transformation reflected restructuring trends in the paper and pulp industry.

  2. 2013 USGS-NRCS Lidar: Maine (Cumberland, Kennebec and York)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — TASK NAME: NRCS Maine 0.7M NPS LIDAR LiDAR Data Acquisition and Processing Production Task USGS Contract No. G10PC00057 Task Order No. G13PD00954 Woolpert Order No....

  3. Culturally and economically important nontimber forest products of northern Maine

    Science.gov (United States)

    Michelle J. Baumflek; Marla R. Emery; Clare. Ginger

    2010-01-01

    Nontimber forest products (NTFPs) gathered for food, medicine, craft, spiritual, aesthetic, and utilitarian purposes make substantial contributions to the economic viability and cultural vitality of communities. In the St. John River watershed of northern Maine, people identifying with cultural groups including Acadian, Maliseet, Mi'kmaq, Scotch-Irish, and Swedish...

  4. Measurements and Computations of Transients in Pumped Sewer Plastic Mains

    DEFF Research Database (Denmark)

    Larsen, Torben; Burrows, Richard

    1992-01-01

    Measurements of pressure and flow in a number of pumped plastic sewer mains have been carried out in order to compare the actual observed transients with computations. Primarily the situation following pump run-down has been studied. The investigation covered pipelines with steadily rising length...

  5. Reading Strategy: Tackling Reading through Topic and Main Ideas

    Science.gov (United States)

    Naidu, Bharathi; Briewin, Marshal; Embi, Mohamed Amin

    2013-01-01

    Reading comprehension is one of the four skills essential in learning English. In a reading class, students tend to read all the information provided in reading materials, but how much do they actually retain? This study explores whether learners use identification of the topic and main ideas as a reading strategy to assist in reading…

  6. Exploring a categorization of main competencies for digital librarians

    OpenAIRE

    Machin-Mastromatteo, Juan-Daniel

    2009-01-01

    This brief essay is concerned with the main topic “Job Analysis in a Digital Library Context” and its purpose is to explore some of the competencies that digital librarians must have to successfully work in a digital library context. The competencies explored are categorized under the headings of information management competencies, technological competencies, information literacy related competencies, and interpersonal competencies.

  7. PRISMA database machine: A distributed, main-memory approach

    NARCIS (Netherlands)

    Schmidt, J.W.; Apers, Peter M.G.; Ceri, S.; Kersten, Martin L.; Oerlemans, Hans C.M.; Missikoff, M.

    1988-01-01

    The PRISMA project is a large-scale research effort in the design and implementation of a highly parallel machine for data and knowledge processing. The PRISMA database machine is a distributed, main-memory database management system implemented in an object-oriented language that runs on top of a m

  8. Motor-Generator powering the PS (Proton Synchrotron) main magnets

    CERN Multimedia

    1983-01-01

    This motor-generator,30 MW peak, 1500 r.p.m.,pulsed power supply for the PS main magnet replaced in 1968 the initial 3000 r.p.m. motor-generator-flywheel set which had served from the PS start-up in 1959 until end 1967. See also photo 8302337 and its abstract.

  9. Blue supergiants as descendants of magnetic main sequence stars

    Science.gov (United States)

    Petermann, I.; Langer, N.; Castro, N.; Fossati, L.

    2015-12-01

    About 10% of the massive main sequence stars have recently been found to host a strong, large scale magnetic field. Both, the origin and the evolutionary consequences of these fields are largely unknown. We argue that these fields may be sufficiently strong in the deep interior of the stars to suppress convection near the outer edge of their convective core. We performed parametrised stellar evolution calculations and assumed a reduced size of the convective core for stars in the mass range 16M⊙ to 28M⊙ from the zero age main sequence until core carbon depletion. We find that such models avoid the coolest part of the main sequence band, which is usually filled by evolutionary models that include convective core overshooting. Furthermore, our "magnetic" models populate the blue supergiant region during core helium burning, i.e., the post-main sequence gap left by ordinary single star models, and some of them end their life in a position near that of the progenitor of Supernova 1987A in the Hertzsprung-Russell diagram. Further effects include a strongly reduced luminosity during the red supergiant stage, and downward shift of the limiting initial mass for white dwarf and neutron star formation.

  10. Non-Vestoid candidates in the inner Main Belt

    Science.gov (United States)

    Moskovitz, Nicholas; Oszkiewicz, Dagmara; Skiff, Brian; Kankiewicz, Pawel; Licandro, Javier; Galiazzo, Mattia; Zeilinger, Werner

    2016-10-01

    Most Howardite-Eucrite-Diogenite (HED) meteorites (analogues to V-type asteroids) are thought to originate from asteroid (4) Vesta. However some HEDs show distinct oxygen isotope ratios and therefore are thought to originate from other asteroids. In this study we try to identify asteroids that may represent parent bodies of those mismatching HEDs. In particular the origin of the anomalous Bunburra Rockhole meteorite was traced back to the inner main asteroid belt, showing that there might be asteroids that are not genetically linked to the asteroid (4) Vesta (the main source of V-type asteroids and HED meteorites) in the inner main belt. In this work we identify V-type asteroids outside the dynamical Vesta family whose rotational properties (retrograde vs prograde rotation) suggest the direction of Yarkovsky drift that sets them apart from typical Vestoids and Vesta fugitives. Specificly Nesvorny et al. 2008 simulated escapes paths from the Vesta family and showed that typical Vesta fugitives in the inner main asteroid belt at semi-major axis a drift or showing Yarkovsky drift direction towards (4) Vesta are the best candidates for non-Vestoidal V-type asteroids and therefore parent bodies of anomalous HED. In this study we have performed accurate photometric observations and determined sense of rotation for several asteroids testing their links to Vesta and anomalous HED. We have found several potential non-Vestoid candidates. Those objects have to be studied in more detail to fully confirm their link to anomalous HEDs.

  11. New resist materials based on polyacetal main chain scission

    Science.gov (United States)

    Manouras, Theodoros; Olziersky, Antonis; Argitis, Panagiotis

    2016-03-01

    The main target of the current work was to develop new polymeric materials for lithographic applications, the main chain of which is cleaved under the influence of photogenerated acid. Acetals have been chosen as functional groups in the main polymer chain since they can be cleaved in the presence of an acid while they remain untouched in alkaline ambient. The synthesized polymers were designed to bear in addition suitable functional groups for the achievement of desirable lithographic characteristics (thermal stability, acceptable glass transition temperature, etch resistance, proper dissolution behaviour). The synthesis was carried out via polyaddition of a vinyloxyl compound and a diol compound to produce novel polymers with acetal repeating units in their backbone. We chose polyaromatic hydrocarbons as diol units to achieve increased etch resistance. In addition, the polyaromatic units allow exposure at 193 nm as well, where the absorption of simple aromatics is prohibitively high. Good solubility and increased surface adhesion were achieved by choosing cycloaliphatic vinyloxyl ethers as the second component for the polyaddition. In addition, the same route can be followed to incorporate chromophores that can tune the resist absorbance in different spectral regions. Furthermore, single component systems can be designed following this approach by the incorporation of suitable PAGs in the main chain.

  12. Urbanization: Main Driving Force in Economic Development in Coming Years

    Institute of Scientific and Technical Information of China (English)

    HuAn'gang; ZhaoBaohua; DavidKelly

    2004-01-01

    The past 25 years has seen an unprecedented exodus of rural immigrants flowing into cities or townships. Coastal China has become the main destination to take in the country's surplus farming labor forces in the rustic population; while the populous central or western provinces,

  13. The Relationships between School Poverty and Student Achievement in Maine

    Science.gov (United States)

    Silvernail, David L.; Sloan, James E.; Paul, Chelsea R.; Johnson, Amy F.; Stump, Erika K.

    2014-01-01

    The goal of this study was to examine the relationships between school level poverty found in Maine schools and student academic performance. The evidence clearly shows that there is a relationship. As the percent of poverty increases in a school, student performance declines. But the poverty level alone does not explain the wide variations in…

  14. Main results of the third international PIV Challenge

    NARCIS (Netherlands)

    Stanislas, M.; Okamoto, K.; Kähler, C.J.; Westerweel, J.; Scarano, F.

    2008-01-01

    This paper presents the main results of the third international PIV Challenge which took place in Pasadena (USA) on the 19th and 20th of September 2005. This workshop was linked to the PIV05 International Symposium held at the same place the same week. The present contribution states the objectives

  15. 30 CFR 75.311 - Main mine fan operation.

    Science.gov (United States)

    2010-07-01

    ... back-up fan system— (1) Only persons necessary to evaluate the effect of the fan stoppage or restart... back-up fan system is used that does not provide the ventilating quantity provided by the main mine fan... fire or other products of combustion are approved in the ventilation plan. (g) If multiple mine...

  16. The renovation of the Main Building is approaching completion

    CERN Document Server

    Anaïs Schaeffer

    2011-01-01

    The renovation work under way in the CERN Main Building should be completed by June. From the floors to the ceilings, everything has been done to give this historic building a new lease of life.     Taken in the early 60s, this picture illustrates how light maintenance was a challenge for the auditorium in CERN’s main building.   Nobody who has recently had to shimmy between the cables, ladders and toolboxes deposited around the main hall of Building 500 to get to the post office, the bank or Restaurant 1 can be oblivious to the fact that the ground floor of the Main Building has been getting a face-lift. The renovation work, which started with the first-floor concourse in June 2010, should be finished over the next couple of months. The first-floor renovations, now almost complete, set the tone for the rest of the project. The floor and ceiling, both fitted with special acoustic materials for efficient noise damping, have been completely refurbished and the Building ...

  17. Integrated geophysical investigations of Main Barton Springs, Austin, Texas, USA

    Science.gov (United States)

    Saribudak, By Mustafa; Hauwert, Nico M.

    2017-03-01

    Barton Springs is a major discharge site for the Barton Springs Segment of the Edwards Aquifer and is located in Zilker Park, Austin, Texas. Barton Springs actually consists of at least four springs. The Main Barton Springs discharges into the Barton Springs pool from the Barton Springs fault and several outlets along a fault, from a cave, several fissures, and gravel-filled solution cavities on the floor of the pool west of the fault. Surface geophysical surveys [resistivity imaging, induced polarization (IP), self-potential (SP), seismic refraction, and ground penetrating radar (GPR)] were performed across the Barton Springs fault and at the vicinity of the Main Barton Springs in south Zilker Park. The purpose of the surveys was two-fold: 1) locate the precise location of submerged conduits (caves, voids) carrying flow to Main Barton Springs; and 2) characterize the geophysical signatures of the fault crossing Barton Springs pool. Geophysical results indicate significant anomalies to the south of the Barton Springs pool. A majority of these anomalies indicate a fault-like pattern, in front of the south entrance to the swimming pool. In addition, resistivity and SP results, in particular, suggest the presence of a large conduit in the southern part of Barton Springs pool. The groundwater flow-path to the Main Barton Springs could follow the locations of those resistivity and SP anomalies along the newly discovered fault, instead of along the Barton Springs fault, as previously thought.

  18. Main types of skin cancer and treatment options.

    Science.gov (United States)

    Alexander, Rachel Louise

    This first in a two-part series on skin cancer gives an overview of the most common types and outlines the main treatment options. Part 2, to be published next week, discusses the causes of and risk factors for skin cancer, highlighting those people who are most at risk and the importance of early diagnosis.

  19. Space Shuttle Main Engine Liquid Air Insulation Redesign Lessons Learned

    Science.gov (United States)

    Gaddy, Darrell; Carroll, Paul; Head, Kenneth; Fasheh, John; Stuart, Jessica

    2010-01-01

    The Space Shuttle Main Engine Liquid Air Insulation redesign was required to prevent the reoccurance of the STS-111 High Pressure Speed Sensor In-Flight Anomaly. The STS-111 In-Flight Anomaly Failure Investigation Team's initial redesign of the High Pressure Fuel Turbopump Pump End Ball Bearing Liquid Air Insulation failed the certification test by producing Liquid Air. The certification test failure indicated not only the High Pressure Fuel Turbopump Liquid Air Insulation, but all other Space Shuttle Main Engine Liquid Air Insulation. This paper will document the original Space Shuttle Main Engine Liquid Air STS-111 In-Flight Anomaly investigation, the heritage Space Shuttle Main Engine Insulation certification testing faults, the techniques and instrumentation used to accurately test the Liquid Air Insulation systems on the Stennis Space Center SSME test stand, the analysis techniques used to identify the Liquid Air Insulation problem areas and the analytical verification of the redesign before entering certification testing, Trade study down selected to three potential design solutions, the results of the development testing which down selected the final Liquid Air Redesign are also documented within this paper.

  20. ANALYSIS OF THE MAIN FACTORS AFFECTING SECONDARY FIBER DEINKING

    Institute of Scientific and Technical Information of China (English)

    Qing Han; Huanbin Liu; Dongbo Yan

    2004-01-01

    The secondary fiber species,main composition of deinking agent,colloid chemistry behavior of deinking process etc. that may influence the deinking result of secondary fiber were analysed in this dissertation, and some thoughts that optimizing the currently deingking technology were also suggested.

  1. Assessing the Food Safety Knowledge of University of Maine Students

    Science.gov (United States)

    Ferk, Chelsea C.; Calder, Beth L.; Camire, Mary Ellen

    2016-01-01

    Foodborne illness is a global public health issue. Young adults may work in foodservice while they are university students, and their habits may later shape the practices and well-being of their children. The objective of this study was to establish baseline data and assess the food safety knowledge of 18- to 26-year-old Univ. of Maine students.…

  2. Identification of the main processes in new towns Development ...

    African Journals Online (AJOL)

    Identification of the main processes in new towns Development Company in Iran and ... of the model of ideal processes for optimal management of resources and actions. ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... has been created that together with manufacturing standards and guidelines, ...

  3. Main Results of the Azerbaijan STEP Employer Survey

    OpenAIRE

    Rutkowski, Jan J.

    2015-01-01

    This note summarizes the main findings of the STEP Employer Skills Survey carried out in Azerbaijan in 2013. The note argues that there is a skills shortage in Azerbaijan. Azeri employers claim that it is difficult to find workers with required skills. The shortage is particularly pronounced in the case of modern, innovative firms, which tend to required more advanced skills. The education...

  4. Demographics of hip dysplasia in the Maine Coon cat.

    Science.gov (United States)

    Loder, Randall T; Todhunter, Rory J

    2017-04-01

    Objectives The aim of this study was to study the demographics of feline hip dysplasia (FHD) in the Maine Coon cat. Methods The complete hip dysplasia registry (public and private) collected by the Orthopedic Foundation for Animals through April 2015 was accessed. There were 2732 unique cats; 2708 (99.1%) were Maine Coons, and only these were studied. Variables analyzed were sex, month/season of birth and hip dysplasia score. Two groups were created: those with and without FHD. P dysplasia were older. The percentage of bilateral FHD was 56%, and bilateral cases had more severe dysplasia than unilateral cases but with no age difference. Month/season of birth or geographic region of origin did not influence the prevalence of FHD. Conclusions and relevance This is the largest demographic study of FHD in the Maine Coon cat. The overall prevalence in the Orthopedic Foundation for Animals registry was 24.9%, and slightly higher in males (27.3%) than females (23.3%). Dysplasia was more severe in bilateral than unilateral cases and with increasing age. Caution should be used when extrapolating these findings to other feline breeds or other groups of Maine Coon cats. Further studies need to be performed among other breeds and geographic locations to better understand the demographics of feline hip dysplasia.

  5. THE MAIN COST-RELATED FACTORS IN AIRLINES MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Olesya Suntsova

    2016-03-01

    Full Text Available This paper analyzes the main factors that affect the strategies to reduce airlines costs. These costs factors were presented to experts from the airline industry through two rounds of questionnaires in sense tobe weighed. It was applied a method based on the structure of the AHP (Analytic Hierarchy Process and the results show that the main important factors for a cost-related airlines strategy are, in importance: routestructure and mesh; type and characteristics of the aircraft; cost of labor and management quality. This hierarchycan help the decision maker when facing the need of defining priorities in reduction costs. past decades despitethe increase in air transportation and significant decrease in average operation costs, it is observed that airlineshave low profitability. The liberalization of the markets and increase opportunities for competition diminishesprices, even when airlines face increasing costs. Considering that advantage in costs is an important strategy forcarriers to remain in the market, this paper analyzes the main factors that affect the strategies to reduce airlinescosts. These costs factors were presented to experts from the airline industry through two rounds ofquestionnaires in sense to be weighed. It was applied a method based on the structure of the AHP (AnalyticHierarchy Process and the results show that the main important factors for a cost-related airlines strategy are, inorder of importance: route structure and mesh; type and characteristics ofthe aircraft; cost of labor andmanagement quality. This hierarchy can help the decision maker when facing the need of defining priorities inreduction costs.

  6. Despite Rough Seas, Teachers in Rural Maine Swim Together

    Science.gov (United States)

    Rhoads, Kyle

    2011-01-01

    When the author became principal of Acton Elementary School in Acton, Maine, in 2003, he spent the summer interviewing staff members. Staff in this small, rural elementary school overwhelmingly expressed a desire for opportunities to learn collaboratively. The teachers described a school culture where staff did not work together but instead worked…

  7. Condition Assessment for Drinking Water Transmission and Distribution Mains

    Science.gov (United States)

    This project seeks to improve the capability to characterize the condition of water infrastructure. The integrity of buried drinking water mains is critical, as it influences water quality, losses, pressure and cost. This research complements the U.S. Environmental Protection A...

  8. Distributions of Quasar Hosts on the Galaxy Main Sequence Plane

    Science.gov (United States)

    Zhang, Zhoujian; Shi, Yong; Rieke, George H.; Xia, Xiaoyang; Wang, Yikang; Sun, Bingqing; Wan, Linfeng

    2016-03-01

    The relation between star formation rates (SFRs) and stellar masses, i.e., the galaxy main sequence, is a useful diagnostic of galaxy evolution. We present the distributions relative to the main sequence of 55 optically selected PG and 12 near-IR-selected Two Micron All Sky Survey (2MASS) quasars at z ≤ 0.5. We estimate the quasar host stellar masses from Hubble Space Telescope or ground-based AO photometry, and the SFRs through the mid-infrared aromatic features and far-IR photometry. We find that PG quasar hosts more or less follow the main sequence defined by normal star-forming galaxies while 2MASS quasar hosts lie systematically above the main sequence. PG and 2MASS quasars with higher nuclear luminosities seem to have higher specific SFRs (sSFRs), although there is a large scatter. No trends are seen between sSFRs and SMBH masses, Eddington ratios, or even morphology types (ellipticals, spirals, and mergers). Our results could be placed in an evolutionary scenario with quasars emerging during the transition from ULIRGs/mergers to ellipticals. However, combined with results at higher redshift, they suggest that quasars can be widely triggered in normal galaxies as long as they contain abundant gas and have ongoing star formation.

  9. Brazil - Improving Fiscal Circumstances for Growth : Volume 2. Main Report

    OpenAIRE

    World Bank

    2007-01-01

    This document is part of a series of reports by the World Bank on Brazil's potential to foment more robust economic growth and reduce poverty and inequality. The main focus of this report is on the interrelated fiscal circumstances facing Brazil, with an emphasis on public sector spending. The report is divided into two volumes. This first volume distills the essential stylized facts (that...

  10. Main Problems of College English Writing and the Method Design

    Institute of Scientific and Technical Information of China (English)

    ZENG Wei

    2014-01-01

    Based on the related theories of Corpus Linguistics and Error Analysis, this paper is aimed to analyze the main prob-lems and errors found in the compositions of arts students and make the mode and method design of self-correction based on in-ternet corpus.

  11. Morphological differential diagnosis of the main types of inflammatory myopathies

    Directory of Open Access Journals (Sweden)

    S. G. Radenska-Lopovok

    2012-01-01

    Full Text Available The review provides an update on the diagnosis of the main subtypes of inflammatory myopathies. Proper choice of biopsied muscle and histological methods of investigation are presented. Histochemical and immunohistochemical characteristic of tissue markers in inflammatory myopathies are given. Some dilemmas, as well as the most common errors of histological diagnostics are discussed.

  12. Accretion disks before (?) the main planet formation phase

    NARCIS (Netherlands)

    Dominik, C.

    2009-01-01

    Protoplanetary disks are the sites of planet formation and therefore one of the foremost targets of future facilities in astronomy. In this review, I will discuss the main options for using JWST and concurrent facilities to study the early, gas-rich, massive phases of protoplanetary disks. We discus

  13. Main Street as Art Museum: Metaphor and Teaching Strategies

    Science.gov (United States)

    Vallance, Elizabeth

    2007-01-01

    A walk down Main Street can be very much like a stroll through a museum gallery--visually rich, inviting unexpected choices, aesthetically rewarding. This article explores the concept of shop windows as visually ordered compositions, much like paintings and other art objects, and suggests some approaches to applying this concept in teaching a…

  14. PRISMA database machine: A distributed, main-memory approach

    NARCIS (Netherlands)

    Apers, Peter M.G.; Kersten, Martin L.; Oerlemans, Hans C.M.; Schmidt, J.W.; Ceri, S.; Missikoff, M.

    1988-01-01

    The PRISMA project is a large-scale research effort in the design and implementation of a highly parallel machine for data and knowledge processing. The PRISMA database machine is a distributed, main-memory database management system implemented in an object-oriented language that runs on top of a m

  15. Trees or Grids? Indexing Moving Objects in Main Memory

    DEFF Research Database (Denmark)

    Sidlauskas, Darius; Saltenis, Simonas; Christiansen, Christian Winther

    2009-01-01

    New application areas, such as location-based services, rely on the efficient management of large collections of mobile objects. Maintaining accurate, up-to-date positions of these objects results in massive update loads that must be supported by spatial indexing structures and main-memory indexes...

  16. Sense of place along a scenic byway in Maine

    Science.gov (United States)

    Marilynne Mann; Jessica Leahy

    2008-01-01

    Sense of place defines the value and meaning of location. The Rangeley Lakes area of Maine, an unusual natural environment with cultural and historic significance, was nationally recognized in 2000 by the designation of the Rangeley Lakes National Scenic Byway. A survey during the summer of 2006 sought to identify sense of place in the midst of tourism-related growth...

  17. The Maine Garlic Project: A Participatory Research and Education Program

    Science.gov (United States)

    Fuller, David; Johnson, Steven B.

    2013-01-01

    Participatory research is a useful technique for collecting basic data over a large geographic area. Garlic production was chosen as a participatory research study focus in Maine. Project participants (285) received bulbs to plant, monitored their crop, and reported data online. Participants received a monthly educational newsletter to improve…

  18. Binary interactions with high accretion rates onto main sequence stars

    Science.gov (United States)

    Shiber, Sagiv; Schreier, Ron; Soker, Noam

    2016-07-01

    Energetic outflows from main sequence stars accreting mass at very high rates might account for the powering of some eruptive objects, such as merging main sequence stars, major eruptions of luminous blue variables, e.g., the Great Eruption of Eta Carinae, and other intermediate luminosity optical transients (ILOTs; red novae; red transients). These powerful outflows could potentially also supply the extra energy required in the common envelope process and in the grazing envelope evolution of binary systems. We propose that a massive outflow/jets mediated by magnetic fields might remove energy and angular momentum from the accretion disk to allow such high accretion rate flows. By examining the possible activity of the magnetic fields of accretion disks, we conclude that indeed main sequence stars might accrete mass at very high rates, up to ≈ 10-2 M ⊙ yr-1 for solar type stars, and up to ≈ 1 M ⊙ yr-1 for very massive stars. We speculate that magnetic fields amplified in such extreme conditions might lead to the formation of massive bipolar outflows that can remove most of the disk's energy and angular momentum. It is this energy and angular momentum removal that allows the very high mass accretion rate onto main sequence stars.

  19. Age-Related Observations of Low Mass Pre-Main and Young Main Sequence Stars (Invited Review)

    CERN Document Server

    Hillenbrand, Lynne A

    2008-01-01

    This overview summarizes the age dating methods available for young sub-solar mass stars. Pre-main sequence age diagnostics include the Hertzsprung-Russell (HR) diagram, spectroscopic surface gravity indicators, and lithium depletion; asteroseismology is also showing recent promise. Near and beyond the zero-age main sequence, rotation period or vsini and activity (coronal and chromospheric) diagnostics along with lithium depletion serve as age proxies. Other authors in this volume present more detail in each of the aforementioned areas. Herein, I focus on pre-main sequence HR diagrams and address the questions: Do empirical young cluster isochrones match theoretical isochrones? Do isochrones predict stellar ages consistent with those derived via other independent techniques? Do the observed apparent luminosity spreads at constant effective temperature correspond to true age spreads? While definitive answers to these questions are not provided, some methods of progression are outlined.

  20. Budget Period 1 Summary Report: Hywind Maine Project

    Energy Technology Data Exchange (ETDEWEB)

    Keiser, Meagan [Statoil, Stavanger (Norway)

    2014-02-28

    In accordance with the Statement of Project Objectives (SOPO) agreed to between the Department of Energy (“DOE”) and Statoil for the Hywind Maine project, Statoil hereby submits a Budget Period 1 Summary Report which includes accomplishments for the project. The report includes summaries of the other submitted reports (see Section 1.2-2) and progress regarding innovations leading to potential reductions in the Cost of Energy (see Section 3). The Hywind Demo project, the world’s first full-scale 2.3 megawatts (MW) floating wind turbine, installed at a water depth of 200 meter (m), 10 kilometer (km) off the coast of Norway, has proven that the Hywind floating substructure is a suitable platform for conventional multi- MW turbines. A principal goal of the Hywind Maine Project was to leverage that experience, both to demonstrate the commercial feasibility of the technology and to further develop and optimize the technology all in order to bring the costs down in a larger scale development. With the Hywind Maine Project, Statoil planned to deploy four turbines of 3 MW in approximately 140 meters water depth. Although the project in Maine will not move forward, much value was gained through the BP1 work package. Advanced modeling related to the design basis, which will have applicability beyond the Maine project, was completed. In addition, initial supply chain analyses were conducted, which will help assist with development of updated cost of energy models. Geophysical and various environmental surveys were also conducted, the results of which Statoil has committed to share publicly, and which will help build a database of information that future developers may be able to access. Finally, Statoil gained a greater understanding of the US offshore wind industry and related markets, which will assist the company as it looks for full-scale, commercial opportunities.

  1. Spectroscopic evolution of massive stars on the main sequence

    Science.gov (United States)

    Martins, F.; Palacios, A.

    2017-02-01

    Context. The evolution of massive stars depends on several parameters, and the relation between different morphological types is not fully constrained. Aims: We aim to provide an observational view of evolutionary models in the Hertzsprung-Russell diagram, on the main sequence. This view should help compare observations and model predictions. Methods: We first computed evolutionary models with the code STAREVOL for initial masses between 15 and 100 M⊙. We subsequently calculated atmosphere models at specific points along the evolutionary tracks, using the code CMFGEN. Synthetic spectra obtained in this way were classified as if they were observational data: we assigned them a spectral type and a luminosity class. We tested our spectral classification by comparison to observed spectra of various stars with different spectral types. We also compared our results with empirical data of a large number of OB stars. Results: We obtain spectroscopic sequences along evolutionary tracks. In our computations, the earliest O stars (O2-3.5) appear only above 50 M⊙. For later spectral types, a similar mass limit exists, but is lower. A luminosity class V does not correspond to the entire main sequence. This only holds for the 15 M⊙ track. As mass increases, a larger portion of the main sequence is spent in luminosity class III. Above 50 M⊙, supergiants appear before the end of core-hydrogen burning. Dwarf stars (luminosity class V) do not occur on the zero-age main sequence above 80 M⊙. Consequently, the distribution of luminosity class V in the HR diagram is not a diagnostic of the length of the main sequence (above 15 M⊙) and cannot be used to constrain the size of the convective core. The distribution of dwarfs and giants in the HR diagram that results from our calculations agrees well with the location of stars analyzed by means of quantitative spectroscopy. For supergiants, there is a slight discrepancy in the sense that luminosity class I is observed slightly

  2. Memoires d'une famille acadienne de Van Buren, Maine (Memoirs of an Acadian Family of Van Buren, Maine).

    Science.gov (United States)

    Cyr, Marguerite

    These memoirs of an Acadian family present aspects of the cultural history of the Acadians in the St. John River Valley in Maine. The six chapters deal with the following topics: (1) a brief history of the land and the people; (2) the chronicles of a large Acadian family from the time of the arrival of their ancestors from France until the…

  3. Two new basaltic asteroids in the Outer Main Belt

    CERN Document Server

    Duffard, R

    2007-01-01

    The identification of other basaltic objects in the asteroid belt is mandatory to explain the diversity in the collection of basaltic meteorites. This diversity requires more than one differentiated parent body, a fact that is consistent with the diversity of differentiated parent bodies implied by the iron meteorites. Based on a list of previously identified candidate basaltic (V-type) asteroids, two asteroids in the outer main belt, (7472) Kumakiri and (10537) 1991 RY16, were spectroscopically observed during an observational run in Calar Alto Observatory, Spain. We confirm the V-type character of these two asteroids that, together with (1459) Magnya, become the only known traces of basaltic found in the outer main belt up to now. We also demonstrate that the searching for candidate V-type asteroids using a photometric survey, like the Sloan Digital Sky Survey, produces reliable results.

  4. I-WARP: Individual Water mAin Renewal Planner

    Directory of Open Access Journals (Sweden)

    Y. Kleiner

    2010-05-01

    Full Text Available I-WARP is based upon a nonhomogeneous Poisson approach to model breakage rates in individual water mains. The structural deterioration of water mains and their subsequent failure are affected by many factors, both static (e.g., pipe material, pipe size, age (vintage, soil type and dynamic (e.g., climate, cathodic protection, pressure zone changes. I-WARP allows for the consideration of both static and dynamic factors in the statistical analysis of historical breakage patterns. This paper describes the mathematical approach and demonstrates its application with the help of a case study. The research project within which I-WARP was developed, was jointly funded by the National Research Council of Canada (NRC, and the Water Research foundation (formerly known as the American Water Works Association Research Foundation – AwwaRF and supported by water utilities from USA and Canada.

  5. Stochastically excited oscillations on the upper main sequence

    DEFF Research Database (Denmark)

    Antoci, Victoria

    2013-01-01

    Convective envelopes in stars on the main sequence are usually connected only with stars of spectral types F5 or later. However, observations as well as theory indicate that the convective outer layers in earlier stars, despite being shallow, are still effective and turbulent enough to stochastic......Convective envelopes in stars on the main sequence are usually connected only with stars of spectral types F5 or later. However, observations as well as theory indicate that the convective outer layers in earlier stars, despite being shallow, are still effective and turbulent enough...... to stochastically excite oscillations. Because of the low amplitudes, exploring stochastically excited pulsations became possible only with space missions such as Kepler and CoRoT. Here I review the recent results and discuss among others, pulsators such as delta Scuti, gamma Doradus, roAp, beta Cephei, Slowly...

  6. CERN's new Career Structure Main Changes in a Nutshell

    CERN Multimedia

    2001-01-01

    All Staff Members will have received an official notification of their position in the new career path structure, with effect from 1 September 2001. A Weekly Bulletin announcement two weeks ago (Bulletin 33/2001) referred to documents and contacts for individual or general information, notably via the HR Division Web site (see below). The present article summarises the main changes between the MOAS and the MAPS (Merit Advancement and Promotion Scheme). The aim of MAPS is to make the career structure more dynamic, while retaining positive elements of the MOAS scheme, notably an annual interview and performance assessment process. The main changes are: - Career reviews including salary band promotion at several stages in a person's career replace the previous automatic grade-to-grade progression within a career path. - Speeds of advancement can be modulated to a greater extent. - The exceptional advancement zone is re-designed. - Premiums or allowances linked to performance, responsibility, and specific labou...

  7. Electron Cloud Measurements in Fermilab Main Injector and Recycler

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Jeffrey Scott [Indiana U.; Backfish, M. [Fermilab; Tan, C. Y. [Fermilab; Zwaska, R. [Fermilab

    2015-06-01

    This conference paper presents a series of electron cloud measurements in the Fermilab Main Injector and Recycler. A new instability was observed in the Recycler in July 2014 that generates a fast transverse excitation in the first high intensity batch to be injected. Microwave measurements of electron cloud in the Recycler show a corresponding depen- dence on the batch injection pattern. These electron cloud measurements are compared to those made with a retard- ing field analyzer (RFA) installed in a field-free region of the Recycler in November. RFAs are also used in the Main Injector to evaluate the performance of beampipe coatings for the mitigation of electron cloud. Contamination from an unexpected vacuum leak revealed a potential vulnerability in the amorphous carbon beampipe coating. The diamond-like carbon coating, in contrast, reduced the electron cloud signal to 1% of that measured in uncoated stainless steel beampipe.

  8. Ostial left main coronary stenosis in a frequent flyer.

    LENUS (Irish Health Repository)

    O'Sullivan, John F

    2009-05-15

    A 52 year old gentleman presented with chest pain, after a long distance flight from India; he had made long haul flights every 2 weeks over the last 5 years as part of his job. His ECG revealed T wave inversion in leads V1-3. Cardiac biomarkers including troponin were negative; we proceeded to exercise stress testing (EST). This revealed 2 mm ST depression at 2 min of the standard Bruce protocol, associated with chest pain. He was taken immediately to the coronary catheterization laboratory; engagement of the left main caused pressure damping with 6 French, then 5 French diagnostic Judkins left 4 catheters. An ostial left main stenosis was seen; the right and left coronary trees otherwise had no significant stenoses. He had normal LV function. He underwent inpatient CABG 7 days later.

  9. Neutrophils and macrophages: The main partners of phagocyte cell systems

    Directory of Open Access Journals (Sweden)

    Manuel T. Silva

    2012-07-01

    Full Text Available Biological cellular systems are groups of cells sharing a set of characteristics, mainly key function and origin. Phagocytes are crucial in the host defense against microbial infection. The previously proposed phagocyte cell systems including the most recent and presently prevailing one, the Mononuclear Phagocyte System (MPS, grouped mononuclear cells but excluded neutrophils, creating an unacceptable situation. As neutrophils are archetypical phagocytes that must be members of comprehensive phagocyte systems, M. T. Silva recently proposed the creation of a Myeloid Phagocyte System (MYPS that adds neutrophils to the MPS. The phagocytes grouped in the MYPS include the leukocytes neutrophils, inflammatory monocytes, macrophages and immature myeloid DCs. Here the justifications behind the inclusion of neutrophils in a phagocyte system is expanded and the MYPS are further characterized as a group of dedicated phagocytic cells that function in an interacting and cooperative way in the host defense against microbial infection. Neutrophils and macrophages are considered the main arms of this system.

  10. Banded ion morphology - Main and recovery storm phases

    Science.gov (United States)

    Frahm, R. A.; Reiff, P. H.; Winningham, J. D.; Burch, J. L.

    1986-01-01

    The occurrence of bands in ion spectra obtained with the high-altitude and low-altitude plasma instruments on DE-1 and DE-2, respectively, during main and recovery storm phases from the period September 1981 - January 1982 is analyzed statistically. Typical spectra are shown; diagrams and graphs of storm morphology are provided; and two theoretical models (one based on time-of-flight effects and another based on convective dispersion) are discussed. It is found that bands occur more often in the main phase than in the recovery phase, and more often and at higher latitudes in the evening than before noon. From the stability of the bands and the dependence of energy on latitude it is inferred that convective dispersion plays a more important role than time-of-flight effects in the motion of heavy ions in the magnetosphere.

  11. Water resources of the Penobscot River basin, Maine

    Science.gov (United States)

    Barrows, Harold Kilbrith; Babb, Cyrus Cates

    1912-01-01

    This report on the Penobscot River drainage system, the largest and one of the most important in Maine, has been compiled chiefly from the records, reports, and maps of the United States Geological Survey and from the results of surveys made in cooperation with the Maine State Survey Commission. The report includes all data on precipitation, stream flow, water storage, and water power that were available at the end of the calendar year 1909 and is accompanied by plans and profiles of the principal rivers, lakes, and ponds in the basin (Pis. XIII-XIX, at end of volume). Stream-flow data for 1910 and 1911 will be published in Water-Supply Papers 281 and 301, respectively.

  12. Structure and Evolution of Pre-Main Sequence Stars

    CERN Document Server

    Schulz, Norbert S; Bautz, Mark W; Canizares, Claude C; Davis, John; Dewey, Dan; Huenemoerder, David P; Heilmann, Ralf; Houck, John; Marshall, Herman L; Nowak, Mike; Schattenburg, Mark; Audard, Marc; Drake, Jeremy; Gagne, Marc; Kastner, Joel; Kallman, Tim; Lautenegger, Maurice; Lee, Julia; Miller, Jon; Montmerle, Thierry; Mukai, Koji; Osten, Rachel; Parerels, Frits; Pollock, Andy; Preibisch, Thomas; Raymond, John; Reale, Fabio; Smith, Randall; Testa, Paola; Weintraub, David

    2009-01-01

    Low-mass pre-main sequence (PMS) stars are strong and variable X-ray emitters, as has been well established by EINSTEIN and ROSAT observatories. It was originally believed that this emission was of thermal nature and primarily originated from coronal activity (magnetically confined loops, in analogy with Solar activity) on contracting young stars. Broadband spectral analysis showed that the emission was not isothermal and that elemental abundances were non-Solar. The resolving power of the Chandra and XMM X-ray gratings spectrometers have provided the first, tantalizing details concerning the physical conditions such as temperatures, densities, and abundances that characterize the X-ray emitting regions of young star. These existing high resolution spectrometers, however, simply do not have the effective area to measure diagnostic lines for a large number of PMS stars over required to answer global questions such as: how does magnetic activity in PMS stars differ from that of main sequence stars, how do they ...

  13. Main drive selection for the Windstorm Simulation Center

    Energy Technology Data Exchange (ETDEWEB)

    Lacy, J.M.; Earl, J.S.

    1998-02-01

    Operated by the Partnership for Natural Disaster Reduction, the Windstorm Simulation Center (WSC) will be a structural test center dedicated to studying the performance of civil structural systems subjected to hurricanes, tornadoes, and other storm winds. Within the WSC, a bank of high-power fans, the main drive, will produce the high velocity wind necessary to reproduce these storms. Several options are available for the main drive, each with advantages and liabilities. This report documents a study to identify and evaluate all candidates available, and to select the most promising system such that the best possible combination of real-world performance attributes is achieved at the best value. Four broad classes of candidate were identified: electric motors, turbofan aircraft engines, turboshaft aircraft engines, and turboshaft industrial engines. Candidate systems were evaluated on a basis of technical feasibility, availability, power, installed cost, and operating cost.

  14. PRESENT STATUS OF THE MAIN SHADS’ POPULATIONS IN PORTUGAL.

    Directory of Open Access Journals (Sweden)

    COSTA M. J.

    2001-07-01

    Full Text Available The allis shad (Alosa alosa and the twaite shad (Alosa fallax are anadromous migratory species, which are threatened not only in Portugal but also in most of their geographic area of distribution. Overfishing and illegal fishing, pollution, physical barriers and river-bed changes seem to be the main reasons for the populations gradual decline. The progressive reduction in the numbers of anadromous fish registered in the last decades in some Portuguese river basins requires urgent action, namely the implementation of measures to promote the recovery of those populations. The current status of shads populations in Portugal is discussed, and the distribution along the main Portuguese watersheds and major threats to these species are presented, as well.

  15. The Main Reasons for Implementing BPM in Czech Companies

    Directory of Open Access Journals (Sweden)

    Tucek David

    2015-09-01

    Full Text Available This article focuses on describing the main aspects and reasons for implementing Business Process Management in Czech companies, and was based on original results of the quantitative research evaluating aspects of process management in the context of company strategies in Czech enterprises which was carried out in 2006 with regard to the extension of its further utilization. Following the interest of professionals in practice, the research continued and was re-implemented in 2012, having the interviews completed in 2013. I have described an evaluation of a process segmentation typology in this article too. The analysis showed that managers have more options regarding process segmentation to choose from. In terms of practicality and ease of use, the method of process segmentation most frequently used (managerial, main and supportive comes directly from the requirements of ISO 9001.

  16. Spatially Resolved Star Formation Main Sequence of Galaxies

    Science.gov (United States)

    Cano-Díaz, M.; Sánchez, S. F.; Zibetti, S.; Ascaribar, Y.; Bland-Hawthorn, J.; Ziegler, B.; González-Delgado, R. M.; Walcher, C. J.; García-Benito, R.; Mast, D.; Mendoza-Pérez, M. A.; Falcón-Barroso, J.; Galbany, L.; Husemann, B.; Kehring, C.; Marino, R. A.; Sánchez-Blázquez, P.; López-Cobá, C.; López-Sánchez, A. R.; Vilchez, J. M.

    2016-06-01

    The relation known as Star Formation Main Sequence (SFMS) of galaxies is defined in terms of stellar mass and star formation rate. This approximately linear relation has been proven to be tight and holds for several star formation indicators at local and at high redshifts. In this talk I will show recent results about our first attempts to study the Spatially Resolved SFMS, using integral field spectroscopic data, coming primarily from the CALIFA survey. I will present as a main result that a local SFMS is found with a slope and zero point of 0.72 +/ 0.04, and -7.95 +/ 0.29 respectively. I will also discuss the influence of characteristics such as environment and morphology in the relation. Finally I will present some extensions of these results for data com in from the MaNGA survey.

  17. Integrated Main Propulsion System Performance Reconstruction Process/Models

    Science.gov (United States)

    Lopez, Eduardo; Elliott, Katie; Snell, Steven; Evans, Michael

    2013-01-01

    The Integrated Main Propulsion System (MPS) Performance Reconstruction process provides the MPS post-flight data files needed for postflight reporting to the project integration management and key customers to verify flight performance. This process/model was used as the baseline for the currently ongoing Space Launch System (SLS) work. The process utilizes several methodologies, including multiple software programs, to model integrated propulsion system performance through space shuttle ascent. It is used to evaluate integrated propulsion systems, including propellant tanks, feed systems, rocket engine, and pressurization systems performance throughout ascent based on flight pressure and temperature data. The latest revision incorporates new methods based on main engine power balance model updates to model higher mixture ratio operation at lower engine power levels.

  18. NVRAM as Main Storage of Parallel File System

    Directory of Open Access Journals (Sweden)

    MALINOWSKI Artur

    2016-05-01

    Full Text Available Modern cluster environments' main trouble used to be lack of computational power provided by CPUs and GPUs, but recently they suffer more and more from insufficient performance of input and output operations. Apart from better network infrastructure and more sophisticated processing algorithms, a lot of solutions base on emerging memory technologies. This paper presents evaluation of using non-volatile random-access memory as a main storage of Parallel File System. The author justifies feasibility of such configuration and evaluates it with MPI I/O, OrangeFS as a file system, two popular cluster I/O benchmarks and software memory simulation. Obtained results suggest, that with Parallel File System highly optimized for block devices, small differences in access time and memory bandwidth does not influence system performance.

  19. A deep space inventory tour of the main asteroid belt

    DEFF Research Database (Denmark)

    Gibbings, Alison; Bowles, Neil; Snodgrass, Colin

    2016-01-01

    A consortium of international scientists and industry partners are proposing the Main Belt Inventory Mission as a candidate in the next forthcoming ESA medium class mission call. The inventory mission will characterise a broad range of statistically significant asteroid samples throughout the Main...... Asteroid Belt (MAB). A 0.5 m aperture space-based telescope will conduct a detailed spectroscopic survey, observing thousands of objects from a range of 0.1-0.5 AU, and perform basic flybys of pre-selected targets. Each flyby will target an asteroid of a different size, taxonomic (sub)classes and orbital...... families, where spatially resolved spectral mapping and spectroscopy will be performed. Smaller and fainter passing targets will also be discovered, through opportunistic science, with dedicated star tracker-like cameras. Examining the compositional diversity across the asteroid population will provide...

  20. Fermilab main injector: High intensity operation and beam loss control

    Science.gov (United States)

    Brown, Bruce C.; Adamson, Philip; Capista, David; Chou, Weiren; Kourbanis, Ioanis; Morris, Denton K.; Seiya, Kiyomi; Wu, Guan Hong; Yang, Ming-Jen

    2013-07-01

    From 2005 through 2012, the Fermilab Main Injector provided intense beams of 120 GeV protons to produce neutrino beams and antiprotons. Hardware improvements in conjunction with improved diagnostics allowed the system to reach sustained operation at 400 kW beam power. Transmission was very high except for beam lost at or near the 8 GeV injection energy where 95% beam transmission results in about 1.5 kW of beam loss. By minimizing and localizing loss, residual radiation levels fell while beam power was doubled. Lost beam was directed to either the collimation system or to the beam abort. Critical apertures were increased while improved instrumentation allowed optimal use of available apertures. We will summarize the improvements required to achieve high intensity, the impact of various loss control tools and the status and trends in residual radiation in the Main Injector.

  1. TERRORISM AS THE MAIN THREAT TO THE STATE DEFENCE

    Directory of Open Access Journals (Sweden)

    T. V. VERBITSKAYA

    2015-01-01

    Full Text Available The article focuses on the analysis of terrorism as the main threat to the state defense. One of the main problems in combating this threat is lack of the uniformity in understanding and definition of terrorism on national and international level, what complicates the search of the means reducing this threat. In addition, because of possible use of armed forces against this threat, the absence of understanding of this term as the basis for introducing relevant legal regimes may lead to violation of human rights. The article presents definitions of terrorism from normative acts of foreign countries and sources of international law. It traces the historical development of the understanding of terrorism in different countries in terms of the evolution of the content of this term.

  2. Beam Loss Control for the Fermilab Main Injector

    CERN Document Server

    Brown, Bruce C

    2013-01-01

    From 2005 through 2012, the Fermilab Main Injector provided intense beams of 120 GeV protons to produce neutrino beams and antiprotons. Hardware improvements in conjunction with improved diagnostics allowed the system to reach sustained operation at 400 kW beam power. Losses were at or near the 8 GeV injection energy where 95% beam transmission results in about 1.5 kW of beam loss. By minimizing and localizing loss, residual radiation levels fell while beam power was doubled. Lost beam was directed to either the collimation system or to the beam abort. Critical apertures were increased while improved instrumentation allowed optimal use of available apertures. We will summarize the impact of various loss control tools and the status and trends in residual radiation in the Main Injector.

  3. HELB Analysis for ESBWR Reactor Building and Main Steam Tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Noguera Oliva, O.

    2011-07-01

    The Reactor Building compartments and tbe Main Steam Tunnel are modeled using GOTHIC 7.2a. These models are based on Control Volumes (Rooms/Compartments/Regions), Flow Paths (junctions such as vent path or any opening) and Boundary Conditions (Mass and energy releases and outside conditions). Due to the different break locations, four models are built to analyze the short-term pressurization response. Are shown the cases analyzed, the results obtained and the models used for this purpose.

  4. Robust Shared Objects for Non-Volatile Main Memory

    OpenAIRE

    Berryhill, Ryan; Golab, Wojciech; Tripunitara, Mahesh

    2016-01-01

    Research in concurrent in-memory data structures has focused almost exclusively on models where processes are either reliable, or may fail by crashing permanently. The case where processes may recover from failures has received little attention because recovery from conventional volatile memory is impossible in the event of a system crash, during which both the state of main memory and the private states of processes are lost. Future hardware architectures are likely to include various forms ...

  5. THE MAIN APPLICATIONS OF THE INTERNET IN TOURISM MARKETING

    OpenAIRE

    Beatrice Sion; Cezar Mihălcescu

    2010-01-01

    The Internet as a marketing media can be of great benefit to virtual all areas of marketing, from marketing research, through market segmentation, targeting and positioning, to the effective use of the marketing mix, and marketing organisation and control. The following discussion does not attempt to provide an exhaustive list of the Net's use in tourism; rather, it simply intends to exemplify its common applications in and main implications for tourism marketing.

  6. Development Tendency in Main Fields of Reading Researches

    Institute of Scientific and Technical Information of China (English)

    石晶

    2011-01-01

    The last few decades have witnessed the publication of a considerable amount of empirical evidence supporting what Krashen has called " the power of reading" ( Krashen, 1993 ). There is a widespread approval that reading itself leads to better reading, better vocabulary, better writing, and better control of grammar in both first and second languages. In this article, the following research areas will be discussed, which can be mainly divided into the following 20 categories.

  7. Thermally curable fluorinated main chain benzoxazine polyethers via Ullmann coupling

    OpenAIRE

    Demirel, A. Levent; Latthe, Sanjay S.; Demir, Kubra Dogan ; Kışkan, Barış; Yağcı, Yusuf

    2013-01-01

    Fluorinated main chain benzoxazine polyethers were prepared by Ullmann coupling of fluorinated benzoxazines in the presence of a nano-copperoxide catalyst. Various parameters such as the monomer structure, temperature, and the effect of catalyst on the polymerization were studied. The benzoxazine groups present in the polyether structure were shown to readily undergo thermally activated ring-opening polymerization in the absence of an added catalyst forming cross-linked networks. The thermal ...

  8. Optimization of main fermentation of high-gravity wort

    OpenAIRE

    Kosiv, Ruslana; Kharandiuk, Tetiana; Polyuzhyn, Lyubov; Palianytsia, Liubov; Berezovska, Natalia

    2016-01-01

    The mathematical model has been developed to calculate the content of higher alcohols and esters depending on wort initial concentration and fermentation temperature. The process was optimized in accordance with the developed model. To obtain high-quality beer via high-gravity brewing technology the wort concentration was found to be 14?15 % relative to dry matter and main fermentation temperature of 284?285 K. ???????? ??????????? ??????, ??? ??? ?????????? ??????????? ????? ????? ??????? ??...

  9. Motor-generator set of the PS main supply

    CERN Multimedia

    Photographic Service; CERN PhotoLab

    1968-01-01

    Already in 1964, the PS improvement programme included a new main magnet supply with more power for the longer cycles needed for slow extraction at the full energy of 26 GeV. This motor-generator set was installed in 1967 and took up service at the beginning of 1968. Regularly serviced and fitted with modern electronic regulation, it pulses the PS to this day.

  10. Gulf of Maine Seals - Populations, Problems and Priorities

    Science.gov (United States)

    2010-06-01

    disease and pinnipeds) and the need of an epidemiologist in further discussions. The top diseases of concern were: (1) morbillivirus, (2) influenza ...epidemiologist. 5. Establish when animals should NOT be released back into wild, as in cases of morbillivirus, influenza , etc. 6. Establish baseline...parasites) Human Health zoonosis , (otitis media, Brucella,*rabies) NOAA to introduce epidemiologist as tool Top 10 diseases of Gulf of Maine

  11. A PREDICTABLE MULTI-THREADED MAIN-MEMORY STORAGE MANAGER

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper introduces the design and implementation of a predictable multi-threaded main-memo- ry storage manager (CS20), and emphasizes the database service mediator(DSM), an operation prediction model using exponential averaging. The memory manager, indexing, as well as lock manager in CS20 are also presented briefly. CS20 has been embedded in a mobile telecommunication service system. Practice showed, DSM effectively controls system load and hence improves the real-time characteristics of data accessing.

  12. Main Ustilaginoidins and Their Distribution in Rice False Smut Balls

    Directory of Open Access Journals (Sweden)

    Jiajia Meng

    2015-10-01

    Full Text Available Rice false smut has become an increasingly serious fungal disease in rice (Oryza sativa L. production worldwide. Ustilaginoidins are bis-naphtho-γ-pyrone mycotoxins previously isolated from the rice false smut balls (FSBs infected by the pathogen Villosiclava virens in rice spikelets on panicles. To investigate the main ustilaginoidins and their distribution in rice FSBs, five main bis-naphtho-γ-pyrones, namely ustilaginoidins A (1, G (2, B (3, I (4 and C (5, were isolated and identified by NMR and high-resolution mass spectrometry as well as by comparison with the data in the literature. The rice FSBs at early, middle and late maturity stages were divided into their different parts and the contents of five main ustilaginoidins for each part were determined by HPLC analysis. The results revealed that the highest levels of ustilaginoidins were in late stage rice FSBs, followed by those at middle stage. Most ustilaginoidins, 96.4% of the total quantity, were distributed in the middle layer at early stage. However, ustilaginoidins were mainly distributed in the outer and middle layers at middle and late stages. Small amounts of ustilaginoidins A (1 and G (2 were found in the inner part of rice FSBs at each maturity stage. The contents of ustilaginoidins A (1 and G (2 without hydroxymethyl groups at C-2 and C-2’ of the γ-pyrone rings in rice FSBs were relatively high at early stage, while the contents of ustilaginoidins B (3, I (4, and C (5 with hydroxymethyl groups at C-2 or C-2’ were relatively high at late stage.

  13. Understanding the Main Problems in Northeast Asia Is the Key

    Institute of Scientific and Technical Information of China (English)

    Feng Yujun

    2012-01-01

    The situation in Northeast Asia is, without doubt, undergoing profound and complex changes, resulting from the interaction of different elements in the political, economic and security fields in the region. Only after painstaking investigation can the main problems in Northeast Asia be understood. In this way, we can avoid an escalation of problems, safeguard regional peace and ensure a benign regional environment for the promotion of the economic development and welfare of various countries.

  14. MANAGEMENT OF MAIN THREATS DURING REALISATION OF BIG SPORT EVENTS

    OpenAIRE

    Agnieszka Ulfik; Stefan Nowak

    2009-01-01

    Organizing major sporting events is inextricably linked with reducing therisks. These risks may be caused by the uncontrolled behavior of the crowd, different typeof accidents or hardware failure as well as terrorist threats. Other main factors creatingdangers currently can be included: problems with safety of filling structure withaudience, control against carrying in dangerous objects, fans reactions which canchange into aggressive behaviours. Correct designing of all elements of sport spec...

  15. The main signs of ageing in people with intellectual disability.

    Science.gov (United States)

    Wark, Stuart; Hussain, Rafat; Edwards, Helen

    2016-12-01

    Investigations around ageing with an intellectual disability have increased substantially in the past three decades. A research gap continued to exist regarding the detection of ageing issues in this cohort of people, particularly in rural areas where access to specialist support continued to be limited. The purpose of this study was to identify the main signs of ageing in rural people with intellectual disabilities. A multi-round Delphi design was used to examine what signs of ageing were observed by disability support staff, who assisted people with intellectual disability. The project was conducted across nine of the ten rural regions (as defined by the government funding body) in New South Wales (NSW). There were 31 participants representing 14 non-government organisations. The group was composed of 26 women and 5 men, with a mean age of 47 years, who averaged 10-year experience with people with intellectual disabilities. The objective was to gain the direct input of rurally based disability workers to identify the main signs of ageing in people with intellectual disabilities. Thirty-two specific signs of ageing, including emerging mental health issues, grief, loss of identity and aggression, were identified. A thematic analysis indicated two main categories: mental/emotional functioning and physical functioning. When carers have the information and skills needed to identify the main signs of ageing, they can more accurately recognise and address potential problems in a timely manner. Such understandings have the potential to reduce premature admissions to residential aged-care. © 2016 National Rural Health Alliance Inc.

  16. Review Study on Main Models of Market Integration

    Institute of Scientific and Technical Information of China (English)

    He Feng

    2008-01-01

    With the endless strengthening of the economic globalization trend, the world market gradually steps into a new turn of the market integration period. Market integration in China is always the key study field of academic communities, but it is developed late, whatever content system or methodology shall be greatly improved as expected. This paper aims at summarizing and reviewing the study on the content system and main demonstrations of market integration in order to provide theoretical guide and methodological basis for related studies.

  17. Protecting Endangered Species: Do the Main Legislative Tools Work?

    OpenAIRE

    Katherine E Gibbs; Currie, David J.

    2012-01-01

    It is critical to assess the effectiveness of the tools used to protect endangered species. The main tools enabled under the U.S. Endangered Species Act (ESA) to promote species recovery are funding, recovery plan development and critical habitat designation. Earlier studies sometimes found that statistically significant effects of these tools could be detected, but they have not answered the question of whether the effects were large enough to be biologically meaningful. Here, we ask: how mu...

  18. Magnetic fields and internal mixing of main sequence B stars

    CERN Document Server

    Wade, G A; Grunhut, J; Landstreet, J D; Petit, V

    2014-01-01

    We have obtained high-quality magnetic field measurements of 19 sharp-lined B-type stars with precisely-measured N/C abundance ratios. Our primary goal is to test the idea that a magnetic field may explain extra drag (through the wind) on the surface rotation, thus producing more internal shear and mixing, and thus could provide an explanation for the appearance of slowly rotating N-rich main sequence B stars.

  19. Rotational Period of Three Main-belt Asteroids

    Science.gov (United States)

    Ferrro, Andrea

    2017-04-01

    CCD photometric observations of three main-belt asteroids were made to find the synodic period and amplitude of their lightcurves: 1264 Letaba, P = 33.27 ± 0.01 h, A = 0.15 mag; 2407 Haug, P = 6.162 ± 0.002 h, A = 0.32 mag; and 5464 Weller, P = 3.288 ± 0.002 h, A = 0.35 mag.

  20. Biomechanical analysis of the main masticatory muscles in the rabbit.

    Science.gov (United States)

    Baron, P; Debussy, T

    1980-09-01

    The main masticatory muscles of the Rabbit (Oryctolagus cuniculus L.) were divided into their 25 component bundles per side. 5 dry skulls were used to determine points of origin and insertion which were then projected onto 3 planes perpendicular to each other, for the establishment of a biomechanical model. By interpreting this model and by examining various mandibular movements, the bundles were classified into 16 functional groups. The findings of other biomechanical studies are contrasted with the results of the study.

  1. THE MAIN APPLICATIONS OF THE INTERNET IN TOURISM MARKETING

    OpenAIRE

    Beatrice Sion; Cezar Mihălcescu

    2010-01-01

    The Internet as a marketing media can be of great benefit to virtual all areas of marketing, from marketing research, through market segmentation, targeting and positioning, to the effective use of the marketing mix, and marketing organisation and control. The following discussion does not attempt to provide an exhaustive list of the Net's use in tourism; rather, it simply intends to exemplify its common applications in and main implications for tourism marketing.

  2. Design of the Main Magnets of the SESAME Storage Ring

    CERN Document Server

    Milanese, A; Shehab, M

    2014-01-01

    This paper describes the magnetic design of the main magnets of the SESAME storage ring. The 16 dipoles are combined function bending magnets, designed with an adjustable iron shimming scheme. The 64 quadrupoles are of two different lengths and strengths. The 64 sextupoles are optimized for field quality in 3D without end pole chamfers and they include additional coils to provide a horizontal/vertical dipole and a skew quadrupole terms.

  3. Historical evolution of the concept of fibromyalgia: the main stages

    Directory of Open Access Journals (Sweden)

    G. Pasero

    2011-09-01

    Full Text Available The concept of fibromyalgia is fairly recent, by evolving from previous notions such as muscular rheumatism and fibrositis. In this concise report the main stages leading to the development of the concept of fibromyalgia are sketched out, beginning from the notions of fibrositis nodules, trigger points and myofascial pain, up to the most recent knowledge including this clinical condition in the cluster of central sensitivity syndromes.

  4. Rotation Period Determination of Four Main-belt Asteroids

    Science.gov (United States)

    Ferrero, Andrea

    2016-10-01

    Observations of four main-belt asteroids (MBA) revealed the following rotation periods and lightcurve amplitudes: 3861 Lorenz, P = 11.91 ± 0.01 h, A = 0.28 mag; 6173 Jimwestphal P = 2.908 ± 0.001 h, A = 0.41 mag; 10259 Osipovyurij, P = 6.356 ± 0.001 h, A = 0.30 mag; 29470 Higgs, P = 36.31 ± 0.01 h, A = 0.48 mag.

  5. Economic Impact of Cruise Ship Passengers in Bar Harbor, Maine

    OpenAIRE

    Gabe, Todd; Lynch, Colleen; McConnon, James; Allen, Thomas

    2003-01-01

    This report examines the economic impact of cruise ship passengers in Bar Harbor, Maine. In 2002, 64 cruise ships docked in Bar Harbor carrying about 120,000 passengers and crewmembers. The analysis presented in the report is based on 1,080 passenger surveys conducted between August and October of 2002. Economic impact figures are based on a total of 97,190 passengers, which is the capacity of the 64 cruise ships that were scheduled to visit Bar Harbor in 2002.

  6. Applications of N-heterocyclic imines in main group chemistry.

    Science.gov (United States)

    Ochiai, Tatsumi; Franz, Daniel; Inoue, Shigeyoshi

    2016-11-07

    The imidazolin-2-imino group is an N-heterocyclic imino functionality that derives from the class of compounds known as guanidines. The exocyclic nitrogen atom preferably bonds to electrophiles and its electron-donating character is markedly enhanced by efficient delocalization of cationic charge density into the five-membered imidazoline ring. Thus, this imino group is an excellent choice for thermodynamic stabilization of electron-deficient species. Due to the variety of available imidazoline-based precursors to this ligand, its steric demand can be tailored to meet the requirements for kinetic stabilization of otherwise highly reactive species. Consequently, it does not come as a surprise that the imidazolin-2-iminato ligand has found widespread applications in transition-metal chemistry to furnish pincer complexes or "pogo stick" type compounds. In comparison, the field of main-group metal compounds of this ligand is still in its infancy; however, it has received growing attention in recent years. A considerable number of electron-poor main-group element species have been described today which are stabilized by N-heterocyclic iminato ligands. These include low-valent metal cations and species that are marked by formerly unknown bonding modes. In this article we provide an overview on the present chemistry of main-group element compounds of the imidazolin-2-iminato ligand, as well as selected examples for the related imidazolidin- and benzimidazolin-2-imino system.

  7. The coronal evolution of pre-main-sequence stars

    CERN Document Server

    Gregory, Scott G; Davies, Claire L

    2016-01-01

    The bulk of X-ray emission from pre-main-sequence (PMS) stars is coronal in origin. We demonstrate herein that stars on Henyey tracks in the Hertzsprung-Russell diagram have lower $\\log(L_X/L_\\ast)$, on average, than stars on Hayashi tracks. This effect is driven by the decay of $L_X$ once stars develop radiative cores. $L_X$ decays faster with age for intermediate mass PMS stars, the progenitors of main sequence A-type stars, compared to those of lower mass. As almost all main sequence A-type stars show no detectable X-ray emission, we may already be observing the loss of their coronae during their PMS evolution. Although there is no direct link between the size or mass of the radiative core and $L_X$, the longer stars have spent with partially convective interiors, the weaker their X-ray emission becomes. This conference paper is a synopsis of Gregory, Adams and Davies (2016).

  8. Radiographic evaluation of cardiac silhouette in healthy Maine Coon cats

    Directory of Open Access Journals (Sweden)

    Caio Sabino de Oliveira

    2014-09-01

    Full Text Available Determining the size of the heart is important for evaluating cardiac patients, because the increase of the cardiac silhouette in the chest radiography can be indicative of heart disease. The vertebral heart size (VHS method is useful because it allows objective assessment of the limits of cardiac silhouette, and can help assess cardiomegaly and document changes in heart size in response to treatment or disease progression. The aim of this study was to compare VHS values of Maine Coon cats (MCC with values cited in the literature (7.5 ± 0.3 vertebrae obtained in non Maine Coon cats (NMCC. Sixty three MCC underwent the physical examination, electrocardiography, echocardiography, laboratory tests (blood count, biochemistry, including liver and kidney function, and total T4, as well as measurement of blood pressure. Faced with normal results, the cats were positioned in right lateral decubitus (right laterallateral projection, to perform chest radiography. The radiographic examinations were performed using the Fuji computed radiography system. The values of VHS found in the animals of this study were 7.61 ± 0.34 vertebrae with a minimum of 6.9 and of maximum 8.5 vertebrae. Statistical analysis performed by Student’s t test identified a significant difference between the values obtained in this study with those in the literature (p = 0.03 for non Maine Coon cats. The highest values of VHS obtained in MCC may be associated with the size of this giant breed.

  9. The Main Drivers of Environmentally Responsible Behaviour in Lithuanian Households

    Directory of Open Access Journals (Sweden)

    Dalia Streimikiene

    2015-08-01

    Full Text Available Preserving environmental and natural resources is one of the most important challenges for ensuring the sustainability of well-being over time. One can notice that measuring of environmental indicators related to environmentally responsible behaviour is complicated and demanding task. It is also important to define the main drivers of environmentally responsible development. The objective of this paper is to provide comparatives analysis of indicators of environmentally responsible behaviour in the Baltic States by comparing and assessing them in terms of the EU-28 average and to present the main drivers of environmentally responsible behaviour in Lithuania. Environmentally responsible behaviour is related to resource and energy savings, use of renewable energy sources, waste sorting and recycling, wastewater disposal etc. Comparative assessment of environmentally responsible behaviour indicators in the Baltic States indicated that all these indicators are bellow the EU-average, except the use of renewable energy sources. The main drivers of consumption behaviour in Lithuania were assessed by applying households surveys in order to define the major issues of concern and to develop relevant policies targeting these issues. Age, gender, education, and income of Lithuanian residents do not have impact on environmentally responsible behaviour in Lithuanian households (energy saving, buying energy efficient electric appliances, willingness to pay electricity from renewable energy sources use of biofuels. Only environmental awareness has impact on energy saving behaviour at home and use of biofuels in cars and waste recycle.

  10. Mitigation of Micropitting in Wind Turbine Main Shaft Bearings

    Energy Technology Data Exchange (ETDEWEB)

    Sethuraman, Latha [National Renewable Energy Lab. (NREL), Golden, CO (United States); Guo, Yi [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sheng, Shuangwen [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-03

    In recent years, increasing evidence of failures has been reported from spherical roller main bearings used in three-point mounting (TPM) drivetrains of wind turbines. One of the leading causes has been micropitting, a failure mode that is possibly overlooked by design, selection and life-prediction tools. It remains to be seen if retrofitting problematic spherical roller bearings (SRBs) with improved bearing design solutions can improve their durability. Questions to ask might be: ‘Are the operating conditions of the main bearing well understood?’ and ‘Are the failures caused by deficient design practice or other unidentified external sources within the system?’ These questions fundamentally challenge the underlying design basis and encourage the need for a system analysis approach that is currently being undertaken by researchers from the National Renewable Energy Laboratory (NREL). Specifically, this article discusses a few potential design alternatives and system-level reassessment to circumvent micropitting in main bearings used in TPM drivetrains.

  11. Metabolism of Dauricine and Identification of Its Main Metabolites

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    To study the metabolism of dauricine in vivo and in vitro and identify the structure of its main metabolites, urine of rats after drug administration as the samples of dauricine metabolism in vivo was studied. Rat liver S9 fraction was prepared and the oxygenation metabolism system reconstituted to perform phase I reaction of dauricine in vitro. TLC, HPLC-DAD and MS were used to analyze and identify dauricine and its main phase I metabolites in the samples. The results showed that besides the untransformed dauricine, in the urine samples there was little product of X' which had the same features of TLC, HPLC-DAD and MS as those of N-desmethyl dauricine (N-ddau). Part of dauricine could be transformed to a main metabolite X after incubating with S9 fraction in appropriate conditions. The molecular ion peak of X was m/z 611. The full scan MS2 spectrum of m/z 611 peak from S9 sample were m/z 580, m/z 566, m/z 552, m/z 206, which were same as those of N-ddau. Liver is the major organ for dauricine metabolism and part of dauricine is biotransformed by liver. The major metabolite is considered to be N-ddau.

  12. MAINS: MULTI-AGENT INTELLIGENT SERVICE ARCHITECTURE FOR CLOUD COMPUTING

    Directory of Open Access Journals (Sweden)

    T. Joshva Devadas

    2014-04-01

    Full Text Available Computing has been transformed to a model having commoditized services. These services are modeled similar to the utility services water and electricity. The Internet has been stunningly successful over the course of past three decades in supporting multitude of distributed applications and a wide variety of network technologies. However, its popularity has become the biggest impediment to its further growth with the handheld devices mobile and laptops. Agents are intelligent software system that works on behalf of others. Agents are incorporated in many innovative applications in order to improve the performance of the system. Agent uses its possessed knowledge to react with the system and helps to improve the performance. Agents are introduced in the cloud computing is to minimize the response time when similar request is raised from an end user in the globe. In this paper, we have introduced a Multi Agent Intelligent system (MAINS prior to cloud service models and it was tested using sample dataset. Performance of the MAINS layer was analyzed in three aspects and the outcome of the analysis proves that MAINS Layer provides a flexible model to create cloud applications and deploying them in variety of applications.

  13. Main trends of the international market of educational services

    Directory of Open Access Journals (Sweden)

    T. I. Chinaeva

    2017-01-01

    Full Text Available The world education system everything will more be transformed to the multi-billion industry, one of the profitable directions of which is training of foreign students. Creation and development of successfully functioning system of the international education, attraction of a significant amount of foreign students are not only to increase the budget of higher education institution and to lift its prestige, but also and a method of promotion of policy, culture, economy, a conduct of life of the host country home. With respect there to research and practical interest has studying and the analysis of the main directions of development of the international market of educational services. This article in which changes of the main indicators reflecting the main vectors of export of education in the leading countries - exporters and in our country are considered is also devoted to these questions.The purpose of work is the analysis of development of the international market of educational services in recent years. The analysis of analytical and statistical information on the processes happening in this area, both at the international level, and in Russia is the basis.In the course of the research the methods of the analytical and logical analysis on the basis of statistical data promoting more detailed studying of dynamic and structural changes of the social and economic phenomena and processes were used.In general for the last 30 years the extent of the international student’s mobility increased more than by 6 times. The international educational market constantly develops, increasing the turnover. However flows of the international students periodically change the orientation, both on countries of source, and over the countries of training. At the same time it is possible to note that changes in structure of the largest countries recipients happen more slowly, than as a part of the countries delivering foreign students. The largest world sources of

  14. MAIN-SEQUENCE STAR POPULATIONS IN THE VIRGO OVERDENSITY REGION

    Energy Technology Data Exchange (ETDEWEB)

    Jerjen, H.; Da Costa, G. S.; Tisserand, P. [Research School of Astronomy and Astrophysics, Australian National University, Mt Stromlo Observatory, via Cotter Road, Weston, ACT 2611 (Australia); Willman, B. [Haverford College, Department of Astronomy, 370 Lancaster Avenue, Haverford, PA 19041 (United States); Arimoto, N. [National Astronomical Observatory of Japan, Subaru Telescope, 650 North A' ohoku Place, Hilo, HI 96720 (United States); Okamoto, S. [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Mateo, M. [Department of Astronomy, University of Michigan, Ann Arbor, MI (United States); Saviane, I. [European Southern Observatory, Casilla 19001, Santiago 19 (Chile); Walsh, S. [Australian Astronomical Observatory, PO Box 915, North Ryde, NSW 1670 (Australia); Geha, M. [Astronomy Department, Yale University, New Haven, CT 06520 (United States); Jordan, A.; Zoccali, M. [Departamento de Astronomia y Astrofisica, Pontificia Universidad Catolica de Chile, 7820436 Macul, Santiago (Chile); Olszewski, E. [Steward Observatory, University of Arizona, Tucson, AZ (United States); Walker, M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Kroupa, P. [Argelander Institute for Astronomy, University of Bonn, Auf dem Huegel 71, D-53121 Bonn (Germany)

    2013-05-20

    We present deep color-magnitude diagrams (CMDs) for two Subaru Suprime-Cam fields in the Virgo Stellar Stream (VSS)/Virgo Overdensity (VOD) and compare them to a field centered on the highest concentration of Sagittarius (Sgr) Tidal Stream stars in the leading arm, Branch A of the bifurcation. A prominent population of main-sequence stars is detected in all three fields and can be traced as faint as g Almost-Equal-To 24 mag. Using theoretical isochrone fitting, we derive an age of 9.1{sup +1.0}{sub -1.1} Gyr, a median abundance of [Fe/H] = -0.70{sup +0.15}{sub -0.20} dex, and a heliocentric distance of 30.9 {+-} 3.0 kpc for the main sequence of the Sgr Stream Branch A. The dominant main-sequence populations in the two VSS/VOD fields ({Lambda}{sub Sun} Almost-Equal-To 265 Degree-Sign , B{sub Sun} Almost-Equal-To 13 Degree-Sign ) are located at a mean distance of 23.3 {+-} 1.6 kpc and have an age of {approx}8.2 Gyr, and an abundance of [Fe/H] = -0.67{sup +0.16}{sub -0.12} dex, similar to the Sgr Stream stars. These statistically robust parameters, derived from the photometry of 260 main-sequence stars, are also in good agreement with the age of the main population in the Sgr dwarf galaxy (8.0 {+-} 1.5 Gyr). They also agree with the peak in the metallicity distribution of 2-3 Gyr old M giants, [Fe/H] Almost-Equal-To -0.6 dex, in the Sgr north leading arm. We then compare the results from the VSS/VOD fields with the Sgr Tidal Stream model by Law and Majewski based on a triaxial Galactic halo shape that is empirically calibrated with Sloan Digital Sky Survey Sgr A-branch and Two Micron All Sky Survey M-giant stars. We find that the most prominent feature in the CMDs, the main-sequence population at 23 kpc, is not explained by the model. Instead the model predicts in these directions a low-density filamentary structure of Sgr debris stars at {approx}9 kpc and a slightly higher concentration of Sgr stars spread over a heliocentric distance range of 42-53 kpc. At best

  15. Advanced Health Management System for the Space Shuttle Main Engine

    Science.gov (United States)

    Davidson, Matt; Stephens, John

    2004-01-01

    Boeing-Canoga Park (BCP) and NASA-Marshall Space Flight Center (NASA-MSFC) are developing an Advanced Health Management System (AHMS) for use on the Space Shuttle Main Engine (SSME) that will improve Shuttle safety by reducing the probability of catastrophic engine failures during the powered ascent phase of a Shuttle mission. This is a phased approach that consists of an upgrade to the current Space Shuttle Main Engine Controller (SSMEC) to add turbomachinery synchronous vibration protection and addition of a separate Health Management Computer (HMC) that will utilize advanced algorithms to detect and mitigate predefined engine anomalies. The purpose of the Shuttle AHMS is twofold; one is to increase the probability of successfully placing the Orbiter into the intended orbit, and the other is to increase the probability of being able to safely execute an abort of a Space Transportation System (STS) launch. Both objectives are achieved by increasing the useful work envelope of a Space Shuttle Main Engine after it has developed anomalous performance during launch and the ascent phase of the mission. This increase in work envelope will be the result of two new anomaly mitigation options, in addition to existing engine shutdown, that were previously unavailable. The added anomaly mitigation options include engine throttle-down and performance correction (adjustment of engine oxidizer to fuel ratio), as well as enhanced sensor disqualification capability. The HMC is intended to provide the computing power necessary to diagnose selected anomalous engine behaviors and for making recommendations to the engine controller for anomaly mitigation. Independent auditors have assessed the reduction in Shuttle ascent risk to be on the order of 40% with the combined system and a three times improvement in mission success.

  16. Flood of April and May 2008 in Northern Maine

    Science.gov (United States)

    Lombard, Pamela J.

    2010-01-01

    Severe flooding occurred in Aroostook and Penobscot Counties in northern Maine between April 28 and May 1, 2008, and was most extreme in the town of Fort Kent. Peak streamflows in northern Aroostook County were the result of a persistent heavy snowpack that caused high streamflows when it quickly melted during the third week of April 2008. Snowmelt was followed by from two to four inches of rainfall over a 2-day period in northern Maine. Peak water-surface elevations resulting from the flood were obtained from 13 continuous-record streamgages and 63 surveyed high-water marks in Aroostook and Penobscot Counties. Peak streamflows were obtained from 20 sites on 15 streams through stage/discharge rating curves or hydraulic flow models. Peak water-surface elevations and streamflows were the highest ever recorded at seven continuous-record streamgages, which had between 25 and 84 years of record in northern Aroostook County. The annual exceedance probability (the percent chance of exceeding the streamflow recorded during the April/May 2008 flood during any given year) at six streamgages in northern Maine was equal to or less than 1 percent. Data from flood-insurance studies published by the Federal Emergency Management Agency were available for five of the locations analyzed for the April/May 2008 flood and were compared to streamflows and observed peak water-surface elevations from the 2008 flood. Water-surface elevations that would be expected given the observed flow as applied to the effective flood insurance studies ranged from between 1 and 4 feet from the water-surface elevations observed during the 2008 flood. Differences were likely the result of up to 30 years of additional data for the calculation of recurrence intervals and the fact that hydraulic models used for the models had not previously been calibrated to a flood of this magnitude.

  17. Modern wind energy technology for Russian applications. Main report

    Energy Technology Data Exchange (ETDEWEB)

    Hauge Madsen, P.; Winther-Jensen, M., Bindner, H.W. [and others

    1999-05-01

    The general objective of the project is to establish a technical foundation for an intensified application of wind energy in Russia with medium to large wind turbines and transfer/adaptation of Danish and European wind turbine technology as a basis for future joint ventures and technology exports. More specifically, the objective is to develop and establish the basic knowledge and design criteria for adaptation and development of Danish wind turbine technology for application under Russian conditions. The research programme is envisaged to be carried out in three phases, the first phase being the project reported herein. The main purpose of phase 1 is to assess the needs for modifications and adaptations of established standard (in casu Danish) wind turbine designs for decentralised energy systems with a limited number of medium sized wind turbines and for grid connected wind turbines in cold climate and in-land sites of Russia. As part of this work it is necessary to clarify the types of operational conditions and requirements that are to be met by wind turbines operating in such conditions, and to outline suitable test procedures and test set-up is for verifications of such adapted and modified wind turbines. The reporting of this project is made in one main report and four topical reports, all of them issued as Risoe reports. This is the Main Report, (Risoe-R-1069), summing up the activities and findings of phase 1 and outlining a strategy for Russian-Danish cooperation in wind energy as agreed upon between the Russian and the Danish parties. (au)

  18. Total Phosphorus Loads for Selected Tributaries to Sebago Lake, Maine

    Science.gov (United States)

    Hodgkins, Glenn A.

    2001-01-01

    The streamflow and water-quality datacollection networks of the Portland Water District (PWD) and the U.S. Geological Survey (USGS) as of February 2000 were analyzed in terms of their applicability for estimating total phosphorus loads for selected tributaries to Sebago Lake in southern Maine. The long-term unit-area mean annual flows for the Songo River and for small, ungaged tributaries are similar to the long-term unit-area mean annual flows for the Crooked River and other gaged tributaries to Sebago Lake, based on a regression equation that estimates mean annual streamflows in Maine. Unit-area peak streamflows of Sebago Lake tributaries can be quite different, based on a regression equation that estimates peak streamflows for Maine. Crooked River had a statistically significant positive relation (Kendall's Tau test, p=0.0004) between streamflow and total phosphorus concentration. Panther Run had a statistically significant negative relation (p=0.0015). Significant positive relations may indicate contributions from nonpoint sources or sediment resuspension, whereas significant negative relations may indicate dilution of point sources. Total phosphorus concentrations were significantly larger in the Crooked River than in the Songo River (Wilcoxon rank-sum test, pestimate the annual total phosphorus load for Crooked River, Northwest River, and Rich Mill Pond Outlet for water years 1996-98. The MOVE.1 method was used to estimate daily streamflows for the regression method at Northwest River and Rich Mill Pond Outlet, where streamflows were not continuously monitored. An averaging method also was used to compute annual loads at the three sites. The difference between the regression estimate and the averaging estimate for each of the three tributaries was consistent with what was expected from previous studies.

  19. Erigeron sumatrensis, das Sumatra-Berufkraut, in Frankfurt am Main

    OpenAIRE

    Buttler, Karl Peter

    2007-01-01

    Erigeron sumatrensis ist seit 1981 in Frankfurt am Main als Neophyt bekannt. Das gegenwärtige Verbreitungsmuster deutet darauf hin, dass die Art sich langsam ausbreitet. Um ihr Erkennen zu erleichtern, wird ein Bestimmungsschlüssel für die in Europa vorkommenden annuellen Adventivarten der Sektion Conyza beigegeben, ergänzt durch einige Anmerkungen zu noch offenen taxonomischen Fragen. Für drei Herkünfte aus Frankreich wurde die hexaploide Chromosomenzahl 2n = 54 ermittelt. Erigeron sumatr...

  20. Massive pre-main-sequence stars in M17

    Science.gov (United States)

    Ramírez-Tannus, M. C.; Kaper, L.; de Koter, A.; Tramper, F.; Bik, A.; Ellerbroek, L. E.; Ochsendorf, B. B.; Ramírez-Agudelo, O. H.; Sana, H.

    2017-08-01

    The formation process of massive stars is still poorly understood. Massive young stellar objects (mYSOs) are deeply embedded in their parental clouds; these objects are rare, and thus typically distant, and their reddened spectra usually preclude the determination of their photospheric parameters. M17 is one of the best-studied H ii regions in the sky, is relatively nearby, and hosts a young stellar population. We have obtained optical to near-infrared spectra of previously identified candidate mYSOs and a few OB stars in this region with X-shooter on the ESO Very Large Telescope. The large wavelength coverage enables a detailed spectroscopic analysis of the photospheres and circumstellar disks of these candidate mYSOs. We confirm the pre-main-sequence (PMS) nature of six of the stars and characterise the O stars. The PMS stars have radii that are consistent with being contracting towards the main sequence and are surrounded by a remnant accretion disk. The observed infrared excess and the double-peaked emission lines provide an opportunity to measure structured velocity profiles in the disks. We compare the observed properties of this unique sample of young massive stars with evolutionary tracks of massive protostars and propose that these mYSOs near the western edge of the H ii region are on their way to become main-sequence stars ( 6-20 M⊙) after having undergone high mass accretion rates (Ṁacc 10-4-10-3M⊙yr-1). Their spin distribution upon arrival at the zero age main-sequence is consistent with that observed for young B stars, assuming conservation of angular momentum and homologous contraction. Based on observations collected at the European Southern Observatory at Paranal, Chile (ESO programmes 60.A-9404(A), 085.D-0741, 089.C-0874(A), and 091.C-0934(B)).The full normalised X-shooter spectra are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/604/A78