Navigazioni letterarie. L’immaginario marino di Dragan Velikić

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Maria Rita Leto

2016-02-01

Full Text Available This article explores the function of the sea images in the fiction of the Serbian contemporary writer Dragan Velikić. The sea, a traditional symbol in world’s literature, is a key image in this writer’s texts, so much so that it amounts to nothing less than imagery of its own in his oeuvre. Imagery, however, that is very different from that handed down by the sea tradition. The author contends that the sea imagery, disseminated throughout Velikić’s works, allows the writer to create a network of intertextual references within his macro-text. At a deeper level, moreover, this imagery seems to have a twofold function in Velikić’s narrative: on the one hand, it mediates the writer’s complex relationship with the literary tradition of the past; on the other, it constitutes the core around which Velikić builds a number of virtual autobiographies: fictions conjuring up the past, both personal and cultural, permeated with auto-biographical overtones, Velikić’s stories evoke in their male protagonists various aspects of the author’s life, as well as of literary figures of the past, while never really giving rise to a full-fledged self-portrait. Thus, his stories, like ships navigating the sea, traverse several boundaries (between genres, historical and fictional self, past and present, life and literature, creating, through his idiosyncratic sea imagery, a fascinating narrative world.

Transgenic Rat Models for Breast Cancer Research

Science.gov (United States)

1996-10-01

colleagues, Dr. Henry Pitot , an expert in hepatocarcinogenesis, and Dr. Michael Gould, an expert in breast cancer. Through our initial attempts at...974-978. 29. Dragan, Y.P. and H.C. Pitot . 1992. The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis

Ekspert : Pärnul tuleks jutustada oma lugu / Anu Jürisson, Karin Klaus

Index Scriptorium Estoniae

Jürisson, Anu, 1977-

2009-01-01

Rahvusvahelise kultuuriturismi konverentsist Pärnus ja kultuurianalüütik doktor Dragan Klaici soovitustest ning nägemusest omanäolise Pärnu kultuurielu elavdamiseks. Ants Johanson rääkis Viljandi folkmuusika festivali korraldamisest, külalised Tuula Rintala-Gardin ja Mikael Ahlerup ka teemaparkide loomisest

Missing in Action: the Country Boy

NARCIS (Netherlands)

Erven, E.A.P.B. van

2004-01-01

In the introduction to his report, Dragan observes that the current policy debate about agriculture, rural areas, food and animals "remains in a narrow circle of experts or organized interests that come in with predetermined, firmly entrenched opinions and stances." He hopes the arts can provide new

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. Miodrag Stojiljković. Articles written in Sadhana. Volume 38 Issue 2 April 2013 pp 187-197. Efficient control of servo pneumatic actuator system utilizing by-pass valve and digital sliding mode · Vladislav Blagojević Dragan Šešlija Miodrag Stojiljković Slobodan Dudić · More Details Abstract Fulltext ...

Erratum: The article „Morphometric analysis of collagen and inflammatory cells in periodontal disease” [Morfometrijska analiza kolagena i inflamatornih ćelija u periodontalnoj bolesti]. Vojnosanit pregl 2015; 72(3: 219-224. (DOI:10.2298/VSP130627076G

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Editorial

2017-01-01

Full Text Available The authors and their affiliations were listed as follows: Ranko Golijanin*†, Bojan Kujundžić†, Zoran Milosavljević‡, Dragan R. Milovanovi槆†, Zlatibor Andjelković║, Miroslav Obrenović¶, Radivoje Nikolić**†† *Department of Dentistry, ‡Department of Histology and Embriology, §Department of Pharmacology and Toxicology, **Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; †Faculty of Dental Medicine, ¶Faculty of Medicine, University of East Sarajevo, Foča, Republic of Srpska, Bosnia and Herzegovina; ††Clinical Center “Kragujevac”, Kragujevac, Serbia Listed the authors and their affiliations should read as: Ranko Golijanin*†, Bojan Kujundžić†, Zoran Milosavljević‡, Dragan R. Milovanovi槆†, Zlatibor Andjelković║, Miroslav Obrenović¶, Radivoje Nikolić**†† *Department of Dentistry, ‡Department of Histology and Embriology, §Department of Pharmacology and Toxicology, **Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; ║Department of Histology, Faculty of Medicine, University of Priština, Kosovska Mitrovica, Serbia; †Faculty of Dental Medicine, ¶Faculty of Medicine, University of East Sarajevo, Foča, Republic of Srpska, Bosnia and Herzegovina; ††Clinical Center “Kragujevac”, Kragujevac, Serbia Link to the corrected article 10.2298/VSP130627076G

PAC1 receptor (ADCYAP1R1 genotype and problematic alcohol use in a sample of young women

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Dragan WŁ

2017-06-01

Full Text Available Wojciech Łukasz Dragan,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Center for Behavior Genetic Research, Faculty of Psychology, University of Warsaw, Warsaw, 2Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, 3Faculty of Psychology, University of Warsaw, Warsaw, Poland Background: Recent studies revealed the role of the PAC1 (ADCYAP1R1 gene variability in vulnerability to posttraumatic stress disorder in women. Due to the relatively high comorbidity of posttraumatic stress disorder and substance use disorder, we hypothesized about possible associations between PAC1 gene and problematic alcohol use. Method: The sample studied consisted of 491 women aged 18–28 years (mean age =21.76 years; SD =1.83 and the Alcohol Use Disorders Identification Test was used to assess drinking problems. We successfully genotyped 17 single-nucleotide polymorphisms in the PAC1 gene. Results: Single locus analysis revealed a significant (after correction for multiple testing association between intronic polymorphism rs2302475 and problematic alcohol use (P=0.00048; recessive model. This result was strengthened by the haplotype analysis (P=0.00379. Conclusion: Our results suggest that the PACAP/PAC1 signaling system is implicated in the development of problematic alcohol use in women. Keywords: problematic alcohol use, PAC1 gene, AUDIT, HPA axis

Drugi pored mene. Antologija priča i eseja pisaca Jugoistočne Evrope (anthologie éditée par Ričard Švarc

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Pieter Troch

2009-02-01

Full Text Available L’anthologie Drugi pored mene… (L’Autre à côté de moi. Anthologie de nouvelles et d’essais d’écrivains de l’Europe du sud-est comprend vingt et une nouvelles et essais écrits par des auteurs contemporains serbes (David Albahari, Vladimir Arsenijević, László Végel, Charles Simic, Biljana Srbljanović, Dragan Velikić, kosovars (Beqë Cufaj, croates (Slavenka Drakulić, Bora Ćosić, Miljenko Jergović, Irena Vrkljan, bulgares (Dimitré Dinev, Vladimir Zarev, bosniaques (Aleksandar Hemon, Saša Sta...

Serbian musical criticism and essay writings during the XIXth and the first half of the XXth century as a subject of musicology research

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Vasić Aleksandar N.

2006-01-01

Full Text Available The beginning of 2006 marked two decades since the death of Stana Djurić-Klajn, the first historian of Serbian musical literature. This is the exterior motive for presenting a summary of the state and results of up-to-date musicology research into Serbian musical criticism and essay writings during the XIXth and the first half of the XXth century, alongside the many works dedicated to this branch of national musical history, recently published. In this way the reader is given a detailed background of these studies – mainly the authors' names, books, studies, articles, as well as the problems of this branch of Serbian musicology. The first research is associated with the early years of the XXth century, that is, to the work of bibliography. The pioneer of Serbian ethnomusicology, Vladimir R. Djordjević composed An Essay of the Serbian Musical Bibliography until 1914, noting selected XIXth century examples of Serbian literature on music. Bibliographic research was continued by various institutions and experts during the second half of the XXth century: in Zagreb (today Republic of Croatia; the Yugoslav Institute for Lexicography, Novi Sad (Matica srpska; and Belgrade (Institute for Literature and Art, Slobodan Turlakov, Ljubica Djordjević, Staniša Vojinović etc. In spite of the efforts of these institutions and individuals, a complete analytic bibliography of music in Serbian print of the last two centuries has unfortunately still not been made. The most important contributions to historical research, interpretation and validation of Serbian musical criticism and essay writings were given by Stana Djurić-Klajn, Dr Roksanda Pejović and Dr Slobodan Turlakov. Professor Stana Djurić-Klajn was the first Serbian musicologist to work in this field of Serbian music history. She wrote a significant number of studies and articles dedicated to Serbian musical writers and published their selected readings. Prof. Klajn is the author and editor of the

Reducing potential damages by freshet abatement in hydropower lakes. An argument for financing hydropower projects

International Nuclear Information System (INIS)

Ionescu, Stefan

1996-01-01

Dam reservoirs with significant water volumes (storage coefficients exceeding 8-10%) cause diminishing of the maximum flow downstream, especially due to the aleatory variation of the initial water level in the reservoir. Depending on the flow reduction in the dam, a methodology for determining the flow for the whole water course downstream is proposed, taking into account various potential combinations for flood generation in the catchment area. Differences between potential damages caused by floods in case of natural conditions versus those occurring in case of engineered zones result in important public financial benefits, amounting up to around 30% of the investments required for dam construction. For instance, in the case of hydropower lake Dragan on the Crisul Repede River the damages diminished down to about 50% for downstream watercourse. (authors)

Combinatorial matrix theory

CERN Document Server

Mitjana, Margarida

2018-01-01

This book contains the notes of the lectures delivered at an Advanced Course on Combinatorial Matrix Theory held at Centre de Recerca Matemàtica (CRM) in Barcelona. These notes correspond to five series of lectures. The first series is dedicated to the study of several matrix classes defined combinatorially, and was delivered by Richard A. Brualdi. The second one, given by Pauline van den Driessche, is concerned with the study of spectral properties of matrices with a given sign pattern. Dragan Stevanović delivered the third one, devoted to describing the spectral radius of a graph as a tool to provide bounds of parameters related with properties of a graph. The fourth lecture was delivered by Stephen Kirkland and is dedicated to the applications of the Group Inverse of the Laplacian matrix. The last one, given by Ángeles Carmona, focuses on boundary value problems on finite networks with special in-depth on the M-matrix inverse problem.

Mineralization of nitrogen from pelletized sewage sludge - a laboratory incubation study

International Nuclear Information System (INIS)

Wattiez, Anne-Laure

2000-01-01

Nitrogen limits the productivity of most ecosystems, but can also cause environmental problems. With the increasing amount of sludge generated by better wastewater treatment, land application of pelletized sludge appears as a combined solution to waste disposal and plant nitrogen nutrition issues. Six types of sludge pellets/granules, containing different mixtures of sludge, ash and/or lime have been inoculated and incubated for 8 weeks at 20 deg C in the dark, to study N net mineralisation rates. Laboratory results showed no indication of general differences between sludge/ash and sludge/lime mixtures, with respect to N mineralisation and nitrification, but some differences between Umeaa pellets and GaevIe granules were discernible. The higher net N mineralisation rates in pellets appeared to be related to sludge properties. On the contrary pellets had a low level of nitrification, which might be explained by preliminary heat treatment of the sludge and the seemingly slow recolonization of nitrifiers. It is also believed that considerable amounts of N were lost, and that the major route for these losses was ammonia volatilisation. From an economical point of view, sludge pelletisation appears to be the most cost-effective means of disposal. It transforms sludge into a valuable, odourless and storable fertiliser or heat source. Some income could even be expected. The benefits obtained from an increased tree growth could justify forest fertilisation with pelletized sludge, but further research is needed to determine more precisely the possible growth increment and the consequences on the environment

Mineralization of nitrogen from pelletized sewage sludge - a laboratory incubation study

Energy Technology Data Exchange (ETDEWEB)

Wattiez, Anne-Laure

2000-07-01

Nitrogen limits the productivity of most ecosystems, but can also cause environmental problems. With the increasing amount of sludge generated by better wastewater treatment, land application of pelletized sludge appears as a combined solution to waste disposal and plant nitrogen nutrition issues. Six types of sludge pellets/granules, containing different mixtures of sludge, ash and/or lime have been inoculated and incubated for 8 weeks at 20 deg C in the dark, to study N net mineralisation rates. Laboratory results showed no indication of general differences between sludge/ash and sludge/lime mixtures, with respect to N mineralisation and nitrification, but some differences between Umeaa pellets and GaevIe granules were discernible. The higher net N mineralisation rates in pellets appeared to be related to sludge properties. On the contrary pellets had a low level of nitrification, which might be explained by preliminary heat treatment of the sludge and the seemingly slow recolonization of nitrifiers. It is also believed that considerable amounts of N were lost, and that the major route for these losses was ammonia volatilisation. From an economical point of view, sludge pelletisation appears to be the most cost-effective means of disposal. It transforms sludge into a valuable, odourless and storable fertiliser or heat source. Some income could even be expected. The benefits obtained from an increased tree growth could justify forest fertilisation with pelletized sludge, but further research is needed to determine more precisely the possible growth increment and the consequences on the environment.

Effect of poly-α, γ, L-glutamic acid as a capping agent on morphology and oxidative stress-dependent toxicity of silver nanoparticles

Directory of Open Access Journals (Sweden)

Stevanović M

2011-11-01

Full Text Available Magdalena Stevanović1, Branimir Kovačević2, Jana Petković3, Metka Filipič3, Dragan Uskoković11Institute of Technical Sciences of Serbian Academy of Sciences and Arts, 2Institute of General and Physical Chemistry, Belgrade, Serbia; 3Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, SloveniaAbstract: Highly stable dispersions of nanosized silver particles were synthesized using a straightforward, cost-effective, and ecofriendly method. Nontoxic glucose was utilized as a reducing agent and poly- α, γ, L-glutamic acid (PGA, a naturally occurring anionic polymer, was used as a capping agent to protect the silver nanoparticles from agglomeration and render them biocompatible. Use of ammonia during synthesis was avoided. Our study clearly demonstrates how the concentration of the capping agent plays a major role in determining the dimensions, morphology, and stability, as well as toxicity of a silver colloidal solution. Hence, proper optimization is necessary to develop silver colloids of narrow size distribution. The samples were characterized by Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, and zeta potential measurement. MTT assay results indicated good biocompatibility of the PGA-capped silver nanoparticles. Formation of intracellular reactive oxygen species was measured spectrophotometrically using 2,7-dichlorofluorescein diacetate as a fluorescent probe, and it was shown that the PGA-capped silver nanoparticles did not induce intracellular formation of reactive oxygen species.Keywords: silver nanoparticles, poly-α, γ, L-glutamic, green synthesis, morphology, cytotoxicity

The mysterious Misirlou

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Todorović Predrag

2013-01-01

Full Text Available My article deals with an unusual story on the roots of a song that has left a significant imprint on the twentieth century popular music all over the world. It is the song Misirlou, created somewhere on the territory of the Ottoman Empire, probably in Asia Minor. The author of this song is unknown. It was created in the so-called rebetiko musical style, typical of the Greeks from Asia Minor, who developed that style after the World War I. The first recordings of this song were made in the 1930s by Greek musicians Tethos Demetriades and Mihalis Patrinos. In no time, there was a true proliferation of different versions of this song, in almost every possible musical genre: jazz, latino, taksym, klezmer, makam, Serbian folk, hip hop, trash metal, pop and rock’n’roll. A number of these versions are mentioned in the article. The fact that this song is considered by many nations – Greeks, Turks, Arabs, Serbs, Jews, Americans – as their own, demonstrates its aptitude for incredible metamorphoses. What attracted me to this song was the story on how it was appropriated into Serbian folk music by the remarkable composer and singer Dragoljub Dragan Toković. The song was called Lela Vranjanka [Lela, the girl from Vranje] and became a standard in the so-called “Vranje folk music”, marvelously interpreted by the singer Staniša Stošić. I also compare various textual versions of Misirlou, in different languages, in order to show its parallel development in verse. [Projekat Ministarstva nauke Republike Srbije, br. 178008: Srpska književnost u evropskom kulturnom prostoru

The value of exfoliative cytology in the diagnostic of oral mucosa changes in diabetes mellitus.

Science.gov (United States)

Mirescu, Ştefan Claudiu; Păiş, Rodica; Stănoiu, Bogdan Petre; Di Natale, Luca; Şovrea, Alina Simona

2016-01-01

In this study, we performed microscopic qualitative analyses of the oral epithelium cytological smears in potential early phase of diabetes and in type 1 and 2 diabetic patients versus a healthy control group. The cytological assessment of the oral changes was realized on superficial and profound smears, from jugal and ventral tongue mucosa and it was based on the comparison between three staining methods [Papanicolaou, APT (polychrome tannin blue)-Dragan and Hematoxylin-Eosin (HE)]. Cytological changes of oral cells population were correlated with the type, duration and complications of diabetes. Oral flora was also evaluated. Irrespective the staining used, we found a clear dividing line between the control group and the real diabetic patients. In all diabetes cases (independently of the type of smear, harvest site, clinical form of disorder and present complications), cells presented alterations both at the level of cytoplasm and nucleus. Dyschromasia, cytolysis, different degrees of fatty degenerescence, binucleated cells, hyperchromasia, nuclear enlargement with modified nuclear÷cytoplasmic ratio, were the most frequent findings. There were no discrepancies in the cellular aspects of type 1 or 2 diabetic patients' smears or between the control group and the potential prediabetic status patients. Findings were interpreted as oral epithelium reactive changes induced by the disease. We concluded that exfoliative cytology alone is of low value as a diagnostic and prognostic tool in the diagnosis of diabetes mellitus (DM); it detects the reactive changes induced by the disease, but it makes no differences between DM types or degree of severity and does not allow by qualitative analysis alone to detect abnormalities in early diabetes.

Quality practices in the field of regional development policy in the Member States of the European Union

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Mihaela Lupăncescu

2017-12-01

Full Text Available Regional issues, by their nature and content, vary widely from one country to another, being the result of specific conditions and factors that characterize each state. As a result, their resolution, in addition to common elements, has many features, both in terms of regional policy objectives, organizational means and spatial structure, zoning and / or regionalization of territory, to create the framework necessary to materialize and implement these objectives .Regional development policy is one of the most important policies of the European Union. At the same time, this socio-economic cohesion policy is one of the most complex in the whole spectrum of Community policies as it interacts with a number of sectoral areas such as agriculture, transport, economic development, environmental protection, employment and vocational training , equal opportunities and gender Thus, regional development policy is indispensable for the achievement of the Union's constitution and activity objectives.Cohesion policy (Dragan G., 2003 includes both regional policy (geared to reducing territorial disparities, regenerating declining industrial areas, providing rural development assistance, social policy issues (such as combating long-term unemployment and supporting the process education and lifelong learning as well as a part of the common agricultural policy (rural development assistance.Article 174 (ex Article 158 TEC of the Treaty on the Functioning of the European Union (consolidated version refers to the harmonious development of the whole of the Union, which is achieved through its actions designed to strengthen its economic, social and territorial cohesion, in particular, to reduce disparities between the levels of development of the various regions and the backwardness of disadvantaged regions, including rural areas.

Detailed mechanism of squalene epoxidase inhibition by terbinafine.

Science.gov (United States)

Nowosielski, Marcin; Hoffmann, Marcin; Wyrwicz, Lucjan S; Stepniak, Piotr; Plewczynski, Dariusz M; Lazniewski, Michal; Ginalski, Krzysztof; Rychlewski, Leszek

2011-02-28

Squalene epoxidase (SE) is a key flavin adenine dinucleotide (FAD)-dependent enzyme of ergosterol and cholesterol biosynthetic pathways and an attractive potential target for drugs used to inhibit the growth of pathogenic fungi or to lower cholesterol level. Although many studies on allylamine drugs activity have been published during the last 30 years, up until now no detailed mechanism of the squalene epoxidase inhibition has been presented. Our study brings such a model at atomic resolution in the case of yeast Saccharomyces cerevisiae . Presented data resulting from modeling studies are in excellent agreement with experimental findings. A fully atomic three-dimensional (3D) model of squalene epoxidase (EC 1.14.99.7) from S. cerevisiae was built with the help of 3D-Jury approach and further screened based on data known from mutation experiments leading to terbinafine resistance. Docking studies followed by molecular dynamics simulations and quantum interaction energy calculations [MP2/6-31G(d)] resulted in the identification of the terbinafine-squalene epoxidase mode of interaction. In the energetically most likely orientation of terbinafine its interaction energy with the protein is ca. 120 kJ/mol. In the favorable position the terbinafine lipophilic moiety is located vertically inside the squalene epoxidase binding pocket with the tert-butyl group oriented toward its center. Such a position results in the SE conformational changes and prevents the natural substrate from being able to bind to the enzyme's active site. That would explain the noncompetitive manner of SE inhibition. We found that the strongest interaction between terbinafine and SE stems from hydrogen bonding between hydrogen-bond donors, hydroxyl group of Tyr90 and amine nitrogen atom of terbinafine. Moreover, strong attractive interactions were recorded for amino acids whose mutations resulted in terbinafine resistance. Our results, elucidating at a molecular level the mode of terbinafine

National consumption of opioid and nonopioid analgesics in Croatia: 2007–2013

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Krnic D

2015-08-01

Full Text Available Darko Krnic,1 Andrea Anic-Matic,2 Svjetlana Dosenovic,2 Pero Draganic,1 Sasa Zezelic,1 Livia Puljak2 1Agency for Medicinal Products and Medical Devices, Zagreb, 2Laboratory for Pain Research, School of Medicine, University of Split, Split, Croatia Background: The increased consumption of analgesics has been documented worldwide during the last 2 decades. The aim of the study was to examine the trends in opioid and nonopioid analgesic consumption in Croatia between 2007 and 2013. Methods: Data on opioid consumption were extracted from the database of the national authority. All opioid and nonopioid analgesics were included in the analysis. Data were presented as defined daily doses per 1,000 inhabitants per day. Adequacy of opioid consumption was calculated using adequacy of consumption measure. Results: During the examined 7-year period, the total consumption and total cost of all analgesics in Croatia showed continuous increase. In the M01A group (anti-inflammatory and antirheumatic products, nonsteroids, ibuprofen had an exponential increasing trend, and in 2011, it overtook diclofenac consumption. Ibuprofen and diclofenac had the highest consumption also in the M02A group of topical products for joint and muscular pain. Tramadol was by far the most consumed type of opioids (N02A group and paracetamol in the group of other analgesics and antipyretics (N02B. The adequacy of consumption measure value was 0.19, indicating that Croatia is a country with a low opioid consumption. Conclusion: Between 2007 and 2013, both consumption of analgesics and their cost in Croatia had an increasing trend. Comparisons with data from other countries, based on the published literature, indicate that analgesic consumption in Croatia is still relatively low. Calculation of the adequacy of opioid consumption indicated that Croatia is a country with low opioid consumption. Further studies are necessary for establishing whether current analgesic consumption in

Cytokine induction of sol–gel-derived TiO2 and SiO2 coatings on metallic substrates after implantation to rat femur

Directory of Open Access Journals (Sweden)

Urbanski W

2017-02-01

Full Text Available Wiktor Urbanski,1 Krzysztof Marycz,2 Justyna Krzak,3 Celina Pezowicz,4 Szymon Feliks Dragan1 1Department of Orthopaedic Surgery and Traumatology, Wroclaw University Hospital, 2Electron Microscope Laboratory, Wroclaw University of Environmental and Life Sciences, 3Institute of Materials Science and Applied Mechanics, 4Division of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wroclaw, Poland Abstract: Material surface is a key determinant of host response on implanted biomaterial. Therefore, modification of the implant surface may optimize implant–tissue reactions. Inflammatory reaction is inevitable after biomaterial implantation, but prolonged inflammation may lead to adverse reactions and subsequent implant failure. Proinflammatory activities of cytokines like interleukin (IL-1, IL-6, and tumor necrosis factor-alpha (TNF-α are attractive indicators of these processes and ultimately characterize biocompatibility. The objective of the study was to evaluate local cytokine production after implantation of stainless steel 316L (SS and titanium alloy (Ti6Al4V biomaterials coated with titanium dioxide (TiO2 and silica (SiO2 coatings prepared by sol–gel method. Biomaterials were implanted into rat femur and after 12 weeks, bones were harvested. Bone–implant tissue interface was evaluated; immunohistochemical staining was performed to identify IL-6, TNF-α, and Caspase-1. Histomorphometry (AxioVision Rel. 4.6.3 software of tissue samples was performed in order to quantify the cytokine levels. Both the oxide coatings on SS and Ti6Al4V significantly reduced cytokine production. However, the lowest cytokine levels were observed in TiO2 groups. Cytokine content in uncoated groups was lower in Ti6Al4V than in SS, although coating of either metal reduced cytokine production to similar levels. Sol–gel TiO2 or SiO2 coatings reduced significantly the production of proinflammatory cytokines by local tissues