thank my loving wife and children for their undying support during my fellowship and career to this point. 1 Chapter 1 Addressing...Future Technology Challenges: Innovate or Die! I thoroughly disapprove of duels . If a man should challenge me, I would take him kindly and...forgivingly by the hand and lead him to a quiet place and kill him. - Mark Twain Duels are foolish. Mark Twain’s approach to conflict resolution is
Chen, Min; Zhang, Yin; Leung, Victor CM
This Springer Brief provides a comprehensive overview of the background and recent developments of big data. The value chain of big data is divided into four phases: data generation, data acquisition, data storage and data analysis. For each phase, the book introduces the general background, discusses technical challenges and reviews the latest advances. Technologies under discussion include cloud computing, Internet of Things, data centers, Hadoop and more. The authors also explore several representative applications of big data such as enterprise management, online social networks, healthcar
Hadar, Ronen; Bilberg, Arne
concepts and technologies that are being developed today which may be used to solve manufacturing challenges in the future, such as: (self) reconfigurable manufacturing systems, (focused) flexible manufacturing systems, and AI inspired manufacturing. The paper will try to offer a critical point of view...... on manufacturing challenges, concepts, and technologies, and is meant to address both academia and industry. Keywords: Reconfigurable manufacturing systems, manufacturing challenges, cognitive factory, mass-customization......This paper presents an examination of Western European manufacturers’ future challenges as can be predicted today. Some of the challenges analyzed in the paper are: globalization, individualism and customization and agility challenges. Hereafter, the paper presents a broad analysis on manufacturing...
Digitalization within the graphic arts industry is described and it is explained how it is improving and changing the print production strategies and which new kinds of print production systems are developed or can be expected. The relationship of printed media and electronic media is analyzed and a positioning for the next century is given. The state of the art of conventional printing technologies, especially using direct imagine techniques, and their position within the digital workflow are shortly described. Non-impact printing multicolor printing systems are explained, based on general design criteria and linked to existing and newly announced equipment. The use of high-tech components for building up successful systems with high reliability, high quality and low production costs is included with some examples. Digital printing systems open many opportunities in print production: distributed printing, personalization, print and book on demand are explained as examples. The overview of the several printing technologies and their positioning regarding quality and productivity leads to the scenario about the important position of printed media, also in the distant future.
Felmy, Andrew R.
EMSL, located in Richland, Washington, is a national scientific user facility operated for the U.S. Department of Energy (DOE) by the Pacific Northwest National Laboratory. The vision that directed the development of EMSL as a problem-solving environment for environmental molecular science has led to significant scientific progress in many areas ranging from subsurface science to atmospheric sciences, and from biochemistry to catalysis. Our scientific staff and users are recognized nationally and internationally for their significant contributions to solving challenging scientific problems. We have explored new scientific frontiers and organized a vibrant and diverse user community in support of our mission as a national scientific user facility that provides integrated experimental and computational resources in the environmental molecular sciences. Users from around the world - from academia to industry and national laboratories to international research organizations - use the resources of EMSL because of the quality of science that we enable.
Dennehy, Cornelius J.
The National Aeronautics and Space Administration (NASA) is currently undergoing a substantial redirection. Notable among the changes occurring within NASA is the stated emphasis on technology development, integration, and demonstration. These new changes within the Agency should have a positive impact on the GN&C discipline given the potential for sizeable investments for technology development and in-space demonstrations of both Autonomous Rendezvous & Docking (AR&D) systems and Autonomous Precision Landing (APL) systems. In this paper the NASA Technical Fellow for Guidance, Navigation and Control (GN&C) provides a summary of the present technical challenges, critical needs, and future technological directions for NASA s GN&C engineering discipline. A brief overview of the changes occurring within NASA that are driving a renewed emphasis on technology development will be presented as background. The potential benefits of the planned GN&C technology developments will be highlighted. This paper will provide a GN&C State-of-the-Discipline assessment. The discipline s readiness to support the goals & objectives of each of the four NASA Mission Directorates is evaluated and the technical challenges and barriers currently faced by the discipline are summarized. This paper will also discuss the need for sustained investments to sufficiently mature the several classes of GN&C technologies required to implement NASA crewed exploration and robotic science missions.
Zamorano, L; Li, Q; Jain, S; Kaur, G
The use of robotic technologies to assist surgeons was conceptually described almost thirty years ago but has only recently become feasible. In Neurosurgery, medical robots have been applied to neurosurgery for over 19 years. Nevertheless this field remains unknown to most neurosurgeons. The intrinsic characteristics of robots, such as high precision, repeatability and endurance make them ideal surgeon's assistants. Unfortunately, limitations in the current available systems make its use limited to very few centers in the world. During the last decade, important efforts have been made between academic and industry partnerships to develop robots suitable for use in the operating room environment. Although some applications have been successful in areas of laparoscopic surgery and orthopaedics, Neurosurgery has presented a major challenge due to the eloquence of the surrounding anatomy. This review focuses on the application of medical robotics in neurosurgery. The paper begins with an overview of the development of the medical robotics, followed by the current clinical applications in neurosurgery and an analysis of current limitations. We discuss robotic applications based in our own experience in the field. Next, we discuss the technological challenges and research areas to overcome those limitations, including some of our current research approaches for future progress in the field.
McCoy, Lise; Pettit, Robin K; Lewis, Joy H; Bennett, Thomas; Carrasco, Noel; Brysacz, Stanley; Makin, Inder Raj S; Hutman, Ryan; Schwartz, Frederic N
Growing up in an era of video games and Web-based applications has primed current medical students to expect rapid, interactive feedback. To address this need, the A.T. Still University-School of Osteopathic Medicine in Arizona (Mesa) has developed and integrated a variety of approaches using technology-enhanced active learning for medical education (TEAL-MEd) into its curriculum. Over the course of 3 years (2010-2013), the authors facilitated more than 80 implementations of games and virtual patient simulations into the education of 550 osteopathic medical students. The authors report on 4 key aspects of the TEAL-MEd initiative, including purpose, portfolio of tools, progress to date regarding challenges and solutions, and future directions. Lessons learned may be of benefit to medical educators at academic and clinical training sites who wish to implement TEAL-MEd activities.
Liu, Gi-Zen; Chiu, Wan-Yu; Lin, Chih-Chung; Barrett, Neil E.
To date, the concept of English for Specific Purposes has brought about a great impact on English language learning across various disciplines, including those in science education. Hence, this review paper aimed to address current English language learning in the science disciplines through the practice of computer-assisted language learning to identify the use of learning technologies in science-based literacy. In the literature review, the researchers found that science-based literacy instruction shares many pedagogical aims with English language teaching in terms of reading, writing, listening and speaking, allowing it to be classified as English for Scientific Purposes (EScP). To answer the research questions, the researchers conducted the survey by extracting related articles and teaching examples from the Web of Science. In the search procedure, the researchers used the keywords science OR scientific AND technolog* OR comput* in ten selected journals of social science citation index. Only articles which are specified as journal articles rather than other document types were included. After compiling the corpora, the researchers compared the trends, methodologies and results of EScP instruction in science education. The implications of this study include the opportunities, advantages and challenges for EScP instruction in science education to further develop better educational approaches, adopt new technologies, as well as offer some directions for researchers to conduct future studies.
Zhang, Yifeng; Angelidaki, Irini
Microbial electrolysis cells (MECs) are an electricity-mediated microbial bioelectrochemical technology, which is originally developed for high-efficiency biological hydrogen production from waste streams. Compared to traditional biological technologies, MECs can overcome thermodynamic limitations and achieve high-yield hydrogen production from wide range of organic matters at relatively mild conditions. This approach greatly reduces the electric energy cost for hydrogen production in contrast to direct water electrolysis. In addition to hydrogen production, MECs may also support several energetically unfavorable biological/chemical reactions. This unique advantage of MECs has led to several alternative applications such as chemicals synthesis, recalcitrant pollutants removal, resources recovery, bioelectrochemical research platform and biosensors, which have greatly broaden the application scopes of MECs. MECs are becoming a versatile platform technology and offer a new solution for emerging environmental issues related to waste streams treatment and energy and resource recovery. Different from previous reviews that mainly focus on hydrogen production, this paper provides an up-to-date review of all the new applications of MECs and their resulting performance, current challenges and prospects of future. Copyright © 2014 Elsevier Ltd. All rights reserved.
This paper attempts an analysis of some current trends and future developments in computer science, education, and educational technology. Based on these trends, two possible future predictions of AIED are presented in the form of a utopian vision and a dystopian vision. A comparison of these two visions leads to seven challenges that AIED might…
Blaen, Phillip; Khamis, Kieran; Lloyd, Charlotte; Bradley, Chris
Excessive nutrient concentrations in river waters threaten aquatic ecosystem functioning and can pose substantial risks to human health. Robust monitoring strategies are therefore required to generate reliable estimates of river nutrient loads and to improve understanding of the catchment processes that drive spatiotemporal patterns in nutrient fluxes. Furthermore, these data are vital for prediction of future trends under changing environmental conditions and thus the development of appropriate mitigation measures. In recent years, technological developments have led to an increase in the use of continuous in-situ nutrient analysers, which enable measurements at far higher temporal resolutions than can be achieved with discrete sampling and subsequent laboratory analysis. However, such instruments can be costly to run and difficult to maintain (e.g. due to high power consumption and memory requirements), leading to trade-offs between temporal and spatial monitoring resolutions. Here, we highlight how adaptive monitoring strategies, comprising a mixture of temporal sample frequencies controlled by one or more 'trigger variables' (e.g. river stage, turbidity, or nutrient concentration), can advance our understanding of catchment nutrient dynamics while simultaneously overcoming many of the practical and economic challenges encountered in typical in-situ river nutrient monitoring applications. We present examples of short-term variability in river nutrient dynamics, driven by complex catchment behaviour, which support our case for the development of monitoring systems that can adapt in real-time to rapid environmental changes. In addition, we discuss the advantages and disadvantages of current nutrient monitoring techniques, and suggest new research directions based on emerging technologies and highlight how these might improve: 1) monitoring strategies, and 2) understanding of linkages between catchment processes and river nutrient fluxes.
Narayanan, S.M.P.; Misra, S.B.C.
The production increases of the next 5 and 10 years are challenges to Coal India. Organized and planned efforts are called for. Coal India is well aware of it and has started gearing itself up to meet the challenges right now. The proposed strategy is as follows: development and adoption of new technologies through indigenous means and by import wherever necessary; upgradation of technology; wider application of new/upgraded technologies already established; commercialization of technologies established with R D work; and R D work. The major areas where work on this strategy has been taken up are: coal exploration; shaft sinking, mine development and mine construction; underground mining; opencast mining; coal handling dispatch; coal beneficiation; coal combustion utilization; slurry pipeline transport of coal; environmental management; and electronics for coal sector, including surface telecommunication network, data base management (computer), and mining electronics, safety, communication and industrial electronics. This paper briefly describes the work being done in each of these areas.
There is increasing availability of a wide range of technology that has the potential to support and enhance the curriculum of the future. Learners expect to use technology for their learning, but this requires the development of information and digital literacy skills to maximise the potential learning opportunities. Learning resources will be increasingly delivered by a variety of mobile devices and also through different immersive and virtual learning environments. Mobile devices and Web 2.0 technology provide opportunities for learners to create their own deep and personalised learning experiences that are relevant for future professional practice. Tutors have a crucial guidance and support role for the effective use of technology for learning. There is a little evidence base to support the impact on learning for many of the potential scenarios and further research is urgently required.
Goosen, Mattheus F A
Recent trends and challenges in applications of renewable energy technologies for water desalination are critically reviewed with an emphasis on environmental concerns and sustainable development. After providing an overview of wind, wave, geothermal, and solar renewable energy technologies for fresh water production, hybrid systems are assessed. Then scale-up and economic factors are considered. This is followed with a section on regulatory factors, environmental concerns, and globalization, and a final segment on selecting the most suitable renewable energy technology for conventional and emerging desalination processes. © 2014 Copyright Taylor & Francis Group, LLC.
Jensen, Jesper Ole; Gram-Hanssen, Kirsten; Røpke, Inge
Increasing consumption of electricity due to a growing number of information and communication technology (ICT) appliances in households is a major challenge to reducing energy consumption. Several studies have predicted escalating ICT-related energy consumption, but relatively little has been said....... Through presentation and discussion of qualitative interviews with families having extensive ICT use in their everyday lives, the interviews illustrate how users domesticate and use technologies in many different ways. The interviews reveal a variety of practices and dynamics in different aspects...... of everyday life, including sport, shopping, entertainment and different hobbies. The growing electricity consumption related to ICT is thus as dependent on the consumers’ use and domestication of the technologies as on the energy efficiency of the appliances. By analysing the interviews with the use...
Full Text Available Pauline Po Yee Lui Headquarter, Hospital Authority, Hong Kong SAR, People's Republic of China Abstract: Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their high proliferative, synthetic, and immunomodulatory activities as well as their potential to differentiate to the target cell types and undergo genetic modification. In this review, I first recapped the challenges of tendon repair by reviewing the anatomy of tendon. Next, I discussed the advantages and limitations of using different types of stem cells compared to terminally differentiated cells for tendon tissue engineering. The safety and efficacy of application of stem cells and their modified counterparts for tendon tissue engineering were then summarized after a systematic literature search in PubMed. The challenges and future research directions to enhance, optimize, and standardize stem cell-based therapies for augmenting tendon repair were then discussed. Keywords: stem cells, tendon repair, tendon tissue engineering, tendon injuries
Jensen, Jesper Ole; Haunstrup Christensen, Toke; Gram-Hanssen, Kirsten (Danish Building Research Inst., Aalborg Univ., Aalborg (Denmark)). e-mail: email@example.com; Roepke, Inge (Dept. of Management Engineering, Aalborg Univ., Aalborg (Denmark))
Increasing consumption of electricity due to a growing number of information and communication technology (ICT) appliances in households is a major challenge to reducing energy consumption. Several studies have predicted escalating ICT-related energy consumption, but relatively little has been said and done about possible initiatives to curb this increase. This paper presents results of a research project focusing on how dynamics of consumption influence household energy consumption on ICT. Results of the project include scenarios on how electricity consumption on ICT is expected to grow, suggesting that in a few years on average ICT will make up half of household electricity consumption. Recent initiatives from various actors to prevent this development are presented and discussed, and difficulties in regulating this area, as compared to other parts of household electricity consumption are highlighted. Through presentation and discussion of qualitative interviews with families having extensive ICT use in their everyday lives, the interviews illustrate how users domesticate and use technologies in many different ways. The interviews reveal a variety of practices and dynamics in different aspects of everyday life, including sport, shopping, entertainment and different hobbies. The growing electricity consumption related to ICT is thus as dependent on the consumers' use and domestication of the technologies as on the energy efficiency of the appliances. By analysing the interviews with the use of theories of domestication of technologies, it is argued that aspects such as consumers' creativity in technology use and their non-adaption are relevant aspects to include in policy and regulation discussions on how to limit the escalating electricity consumption from household ICT use.
K.; N.; TU; TIAN; Tian
Metallurgical challenges in controlling the microstructural stability of Cu and solder microbumps in 3D IC packaging technol-ogy are discussed. Using uni-directional <111> oriented nanotwinned Cu, the controlled growth of oriented Cu6Sn5 on the nanotwinned Cu and its transformation to Cu3Sn without Kirkendall voids have been achieved. In order to join a stack of Si chips into a 3D device, multiple reflows of solder microbumps may be required; we consider localized heating to do so by the use of self-sustained explosive reaction in multi-layered Al/Ni thin films of nano thickness. It avoids re-melting of those solder joints which have been formed already in the 3D stacking structure.
Jaideep Kaur; Kamaljit Kaur
.... IoT exploits RFID tags, NFC, sensors, smart bands, and wired or wireless communication technologies to build smart surroundings, smart Homes, quick-witted intelligence in medical care, ease of Transport, and more...
Recent unprecedented advances in digital technologies and their concomitant affordances in education seem to be a great opportunity to adequately address burgeoning demand for high quality higher education (HE) and the changing educational preferences. It is increasingly being recognised that using new technology effectively in HE is essential to prepare students for its increasing demand. E-learning is an integral component of the University of Botswanaâ€™s teaching and learning culture, how...
Zhang, Yifeng; Angelidaki, Irini
and achieve high-yield hydrogen production from wide range of organic matters at relatively mild conditions. This approach greatly reduces the electric energy cost for hydrogen production in contrast to direct water electrolysis. In addition to hydrogen production, MECs may also support several energetically......Microbial electrolysis cells (MECs) are an electricity-mediated microbial bioelectrochemical technology, which is originally developed for high-efficiency biological hydrogen production from waste streams. Compared to traditional biological technologies, MECs can overcome thermodynamic limitations....... MECs are becoming a versatile platform technology and offer a new solution for emerging environmental issues related to waste streams treatment and energy and resource recovery. Different from previous reviews that mainly focus on hydrogen production, this paper provides an up-to-date review of all...
Pauline Po Yee Lui Headquarter, Hospital Authority, Hong Kong SAR, People's Republic of China Abstract: Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their h...
Rulkens, W.H.; Klapwijk, A.; Willers, H.C.
Agricultural liquid livestock wastes are an important potential source of valuable nitrogen-containing compounds such as ammonia and proteins. Large volumetric quantities of these wastes are produced in areas with a high livestock production density. Much technological research has been carried out
Full Text Available New regulations on pollutants and, specially, on CO2 emissions could restrict the use of the internal combustion engine in automotive applications. This paper presents a review of different technologies under development for meeting such regulations, ranging from new combustion concepts to advanced boosting methods and after-treatment systems. Many of them need an accurate control of the operating conditions and, in many cases, they impose demanding requirements at a system integration level. In this framework, engine control disciplines will be key for the implementation and development of the next generation engines, taking profit of recent advancements in models, methods and sensors. According to authors’ opinion, the internal combustion engine will still be the dominant technology in automotive applications for the next decades.
to leverage game changing technologies such as cyber, robotics , nanotechnology, and ISR to ensure our comparative advantage and ability to achieve...hiring for acquisition workforce positions.”39 Also a dual-track career path would be “established that permits officers and enlisted personnel to...gain experience in a primary career in combat arms and a secondary career in the acquisition field.”40 H.R. 1597 is one of many vehicles attempting
Wei, Kent Hsin-Yu; Qiu, Chang-Hua; Primrose, Ken
Electrical tomography is a relatively new imaging technique that can image the distribution of the passive electrical properties of an object. Since electrical tomography technology was proposed in the 1980s, the technique has evolved rapidly because of its low cost, easy scale-up and non-invasive features. The technique itself can be sensitive to all passive electrical properties, such as conductivity, permittivity and permeability. Hence, it has a huge potential to be applied in many applications. Owing to its ill-posed nature and low image resolution, electrical tomography attracts more attention in industrial fields than biomedical fields. In the past decades, there have been many research developments and industrial implementations of electrical tomography; nevertheless, the awareness of this technology in industrial sectors is still one of the biggest limitations for technology implementation. In this paper, the authors have summarized several representative applications that use electrical tomography. Some of the current tomography research activities will also be discussed. This article is part of the themed issue 'Supersensing through industrial process tomography'.
Full Text Available Zhengwu LuClinical Research Department, Abbott Vascular, Santa Clara, CA, USAAbstract: Risk assessment during clinical product development needs to be conducted in a thorough and rigorous manner. However, it is impossible to identify all safety concerns during controlled clinical trials. Once a product is marketed, there is generally a large increase in the number of patients exposed, including those with comorbid conditions and those being treated with concomitant medications. Therefore, postmarketing safety data collection and clinical risk assessment based on observational data are critical for evaluating and characterizing a product’s risk profile and for making informed decisions on risk minimization. Information science promises to deliver effective e-clinical or e-health solutions to realize several core benefits: time savings, high quality, cost reductions, and increased efficiencies with safer and more efficacious medicines. The development and use of standard-based pharmacovigilance system with integration connection to electronic medical records, electronic health records, and clinical data management system holds promise as a tool for enabling early drug safety detections, data mining, results interpretation, assisting in safety decision making, and clinical collaborations among clinical partners or different functional groups. The availability of a publicly accessible global safety database updated on a frequent basis would further enhance detection and communication about safety issues. Due to recent high-profile drug safety problems, the pharmaceutical industry is faced with greater regulatory enforcement and increased accountability demands for the protection and welfare of patients. This changing climate requires biopharmaceutical companies to take a more proactive approach in dealing with drug safety and pharmacovigilance.Keywords: information technology, pharmacovigilance, safety, standard, risk management, adverse event
Future food security will be dependent upon a combination of the stresses imposed by climate change, variability of weather within the growing season, development of cultivars more suited to different conditions, and the ability to develop effective adaptation strategies which allow these cultivars ...
Jones, Valerie M.; Incardona, F.; Tristram, C.; Virtuoso, S.; Lymberis, A.; Istepanian, R.S.H.; Laxminarayan, S.; Pattichis, C.
Rapid advances in information technology and telecommunications, and in particular mobile and wireless communications, converge towards the emergence of a new type of “infostructure��? that has the potential of supporting a large spectrum of advanced services for healthcare and health. Currently the
Jones, V.M.; Incardona, F.; Tristram, C.; Virtuoso, S.; Lymberis, A.; Istepanian, R.S.H.; Laxminarayan, S.; Pattichis, C.
Rapid advances in information technology and telecommunications, and in particular mobile and wireless communications, converge towards the emergence of a new type of “infostructure” that has the potential of supporting a large spectrum of advanced services for healthcare and health. Currently the I
Stojmenovic, Ivan; Choi, Min; Xhafa, Fatos; FutureTech 2013
Future technology information technology stands for all of continuously evolving and converging information technologies, including digital convergence, multimedia convergence, intelligent applications, embedded systems, mobile and wireless communications, bio-inspired computing, grid and cloud computing, semantic web, user experience and HCI, security and trust computing and so on, for satisfying our ever-changing needs. In past twenty five years or so, Information Technology (IT) influenced and changed every aspect of our lives and our cultures. These proceedings foster the dissemination of state-of-the-art research in all future IT areas, including their models, services, and novel applications associated with their utilization.
Nakagaki, Yoshihiko; Yoshida, Minoru; Noguchi, Yoshikazu
Under the increase of world energy demand, especially in major developing countries, energy demand will not be satisfied without coal. It is true that 30% of carbon dioxide emission is from coal-fired power stations, and there is no other effective solution than abating these emissions. The key is Clean Coal Technologies (CCT), to make power stations to low carbon. It is necessary to develop and transfer these CCTs together with developed and developing countries. Japan, who has excellent CCTs, should play an important role to develop higher innovative technologies and is challenging to make a low carbon society in the world.
Warren, Drake Edward [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Backus, George A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Wendell [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nelson, Thomas R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Skocypec, Russell D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
“Technology empowerment” means that innovation is increasingly accessible to ordinary people of limited means. As powerful technologies become more affordable and accessible, and as people are increasingly connected around the world, ordinary people are empowered to participate in the process of innovation and share the fruits of collaborative innovation. This annotated briefing describes technology empowerment and focuses on how empowerment may create challenges to U.S. national security. U.S. defense research as a share of global innovation has dwindled in recent years. With technology empowerment, the role of U.S. defense research is likely to shrink even further while technology empowerment will continue to increase the speed of innovation. To avoid falling too far behind potential technology threats to U.S. national security, U.S. national security institutions will need to adopt many of the tools of technology empowerment.
Bonastre, O.M.; Montpetit, M.J.; Cesar Garcia, P.S.
The move to IP Protocol Television (IPTV) has challenged the traditional television industry by opening the Internet to high quality real time television content delivery. Thus it has provided an enabling set of key technologies to understand and foster further innovations in the multimedia landscap
For decades, electron-positron colliders have been complementing proton-proton colliders. But the circular LEP, the largest e/sup -/e /sup +/ collider, represented an energy limit beyond which energy losses to synchrotron radiation necessitate moving to e/sup -/e/sup + / linear colliders (LCs), thereby raising new challenges for accelerator builders. Japanese-American, German, and European collaborations have presented options for the "Future Linear Collider " (FLC). Key accelerator issues for any FLC option are the achievement of high enough energy and luminosity. Damping rings, taking advantage of the phenomenon of synchrotron radiation, have been developed as the means for decreasing beam size, which is crucial for ensuring a sufficiently high rate of particle-particle collisions. Related challenges are alignment and stability in an environment where even minute ground motion can disrupt performance, and the ability to monitor beam size. The technical challenges exist within a wider context of socioeconomi...
Thresher, R.; Schreck, S.; Robinson, M.; Veers, P.
This paper describes the current status of wind energy technology, the potential for future wind energy development and the science and engineering challenges that must be overcome for the technology to meet its potential.
Pan, Yi; Kim, Cheonshik; Yang, Yun
The new multimedia standards (for example, MPEG-21) facilitate the seamless integration of multiple modalities into interoperable multimedia frameworks, transforming the way people work and interact with multimedia data. These key technologies and multimedia solutions interact and collaborate with each other in increasingly effective ways, contributing to the multimedia revolution and having a significant impact across a wide spectrum of consumer, business, healthcare, education, and governmental domains. This book aims to provide a complete coverage of the areas outlined and to bring together the researchers from academic and industry as well as practitioners to share ideas, challenges, and solutions relating to the multifaceted aspects of this field.
Proteomics is the study of proteins and their interactions in a cell. With the completion of the Human Genome Project, the emphasis is shifting to the protein compliment of the human organism. Because proteome reflects more accurately on the dynamic state of a cell, tissue, or organism, much is expected from proteomics to yield better disease markers for diagnosis and therapy monitoring. The advent of proteomics technologies for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to gain greater understanding of diseases. High-throughput proteomics technologies combining with advanced bioinformatics are extensively used to identify molecular signatures of diseases based on protein pathways and signaling cascades. Mass spectrometry plays a vital role in proteomics and has become an indispensable tool for molecular and cellular biology. While the potential is great, many challenges and issues remain to be solved, such as mining low abundant proteins and integration of proteomics with genomics and metabolomics data. Nevertheless, proteomics is the foundation for constructing and extracting useful knowledge to biomedical research. In this review, a snapshot of contemporary issues in proteomics technologies is discussed.
Dellaserra, Carla L; Gao, Yong; Ransdell, Lynda
Integrated technology (IT), which includes accelerometers, global positioning systems (GPSs), and heart rate monitors, has been used frequently in public health. More recently, IT data have been used in sports settings to assess training and performance demands. However, the impact of IT in sports settings is yet to be evaluated, particularly in field-based team sports. This narrative-qualitative review provides an overview of the emerging impact of IT in sports settings. Twenty electronic databases (e.g., Medline, SPORTdiscus, and ScienceDirect), print publications (e.g., Signal Processing Magazine and Catapult Innovations news releases), and internet resources were searched using different combinations of keywords as follows: accelerometers, heart rate monitors, GPS, sport training, and field-based sports for relevant articles published from 1990 to the present. A total of 114 publications were identified, and 39 that examined a field-based team sport using a form of IT were analyzed. The articles chosen for analysis examined a field-based team sport using a form of IT. The uses of IT can be divided into 4 categories: (a) quantifying movement patterns (n = 22), (b) assessing the differences between demands of training and competition (n = 12), (c) measuring physiological and metabolic responses (n = 16), and (d) determining a valid definition for velocity and a sprint effort (n = 8). Most studies used elite adult male athletes as participants and analyzed the sports of Australian Rules football, field hockey, cricket, and soccer, with sample sizes between 5 and 20 participants. The limitations of IT in a sports setting include scalability issues, cost, and the inability to receive signals within indoor environments. Integrated technology can contribute to significant improvements in the preparation, training, and recovery aspects of field-based team sports. Future research should focus on using IT with female athlete populations and developing resources to use IT
Hubenthal, M.; Anagnos, T.
exposes all interns to a larger spectrum of research topics and approaches within a field than would be available within a single research site. Evaluations also reveal that fostering social and academic interactions among interns working on generally unrelated projects at separate locations is challenging and requires a consistent, focused effort by the program. In part this is because creating a cohort experience in this situation requires a layer of interaction beyond the networks naturally establish by the interns when co-located. A critical first step is to establish a social presence among the group. This occurs through early face-to-face meetings and then is carried forward as interns transition to virtual interactions. These virtual interactions occur through a variety of technological solutions. Both commercially and freely available technologies such as blogging software, Facebook, an online course management system, virtual worlds, and a variety of online conferencing applications are used to connect the students both synchronously and asynchronously. We have documented the strengths and weaknesses of these individual solutions and show how combinations, combined with programmatic interventions, can offer a suite of functionality necessary to facilitate both social and academic interactions and influence career paths.
Within the conference of the European Society for Sugar Technology (Berlin, Federal Republic of Germany) between 17th and 20th June, 2009 in Rotterdam (The Netherlands) the following lectures were held: (1) Sugar beet quality during long-term storage in clamp and field (A.W.M. Huijbregts); (2) Methods used in the Netherlands to limit frost damage and to process frost-deteriorated beets (J. Strujis, M. Jaspers, M. van Dijk); (3) Biotech in sugarbeet and sugarcane: Current status (T.K. Schwartz, C. Richard); (4) Separation of water through gas hydrate (T. Boech Andersen); (5) Optimised standard of sugar manufacturing - first calculations (F. Lorenz, T. Frankenfeld); (6) Reconsidering vapour compression for sugar crystallization (A. Dolls, M. Bruhns); (7) The development of sustainability standards in the sugar industry (P. Rein); (8) Bioethanol: sugar beet, sugar cane or second generation? (W.J. Corre, J.G. Conijin); (9) The sustainability of beet sugar production in comparison with other sugar crops (P. Christodoulou, V. Kazantzi, S. Bezergianni, K. Gounaris); (10) Alternative products from sugar beets (J. Iciek, S. Wawro); (11) Alternative products from sugar beets (M. Wojtczak); (12) Increase of sugar yield by electrodialysis (J.P. Jenen, P.B. Hansen, M.P. Carter); (13) Optimal dosing of alkalizing agents in the juice purification (G. Roesner, W. Hein, F. Emerstorfer); (14) Affinity based separation technologies and their role in the current and future sugar industry (V. Kochergin); (15) Four to three-stage sugarhouse with two white sugar products (J. Jeppesen, M. Carter); (16) Practical experience of juice decalcification using a weak acid cation exchange resin plant incorporating fractal fluid distribution (E. West, P. Burroughs, P. Seymour); (17) A new process for the production of 'seed crystals' - Process development and field report from the factories (M. Walter, B. Ekelhof, S. Heppner, D. Wullbrandt); (18) Application possibilities and Properties
Interdisciplinary research towards integrated systems and their applications based on emerging convergence of information & communication technologies, micro-nano and bio technologies is expected to have a direct impact in healthcare, ageing population and well being. Micro-Nano-Bio Systems (MNBS) research and development activities under the European Union's R&D Programs, Information & Communication Technologies priority address miniaturised, smart and integrated systems for in-vitro testing (e.g. lab-on-chips) and systems interacting with the human (e.g. autonomous implants, endoscopic capsules and robotics for minimally invasive surgery). Projects addressing in-vitro testing focus on research, development and testing of technology building blocs (e.g. sample preparation technique, ultra sensitive detection technique, chemistry process for molecular recognition and microfluidics) and their integration into smart and miniaturised systems e.g. DNA & protein arrays, biochips, Lab on Chip and Lab on Card. Current challenges and developed solutions as well as open issues to fully meet technological and socioeconomic needs are presented in this paper as background introductory information to the mini-symposium on "MNBS in-vitro testing". Relevant examples of R&D within the group will be presented in the mini-symposium.
New Mexico State Univ., Las Cruces.
Research findings on college instruction and technology and the future are discussed in 15 papers from the first Regional Conference on University Teaching at New Mexico State University. Titles and authors are as follows: "Technology, Teaching, and the Future" (William F. May); "Bauhaus Experience: A Team Method of Teaching Technology" (Euguene…
Stoll, Dieter; Templin, Markus F; Bachmann, Jutta; Joos, Thomas O
Within the last decade protein microarray technology has been successfully applied for the simultaneous identification, quantification and functional analysis of proteins in basic and applied proteome research. These miniaturized and parallelized assay systems have the potential to replace state-of-the-art singleplex analysis systems. However, prior to their general application in robust, reliable, routine and high-throughput applications it is mandatory that they demonstrate robustness, sensitivity, automation and appropriate pricing. In this review, the current state of protein microarray technology will be summarized. Recent applications for the simultaneous determination of a variety of parameters using only minute amounts of sample will be described and future challenges of this cutting-edge technology will be discussed.
Lieshout, M.J. van; Kool, L.
In this paper we will present the results of a technology and policy assessment we have performed on emerging issues and policy challenges of RFID technologies. RFID is a basic component of the future internet of things. A balanced view on opportunities and threats, on drivers and barriers is needed
Lieshout, M.J. van; Kool, L.
In this paper we will present the results of a technology and policy assessment we have performed on emerging issues and policy challenges of RFID technologies. RFID is a basic component of the future internet of things. A balanced view on opportunities and threats, on drivers and barriers is needed
Bjarklev, Araceli; Bjarklev, Anders Overgaard
LED technology will be part of the development, but hybrid illumination systems can also play an important role for the future illumination systems in the tertiary sector in the future. From the ecodesign perspective, the study points out that some of the major technological and economic challenges...
Full Text Available In recent years, learning analytics (LA has attracted a great deal of attention in technology-enhanced learning (TEL research as practitioners, institutions, and researchers are increasingly seeing the potential that LA has to shape the future TEL landscape. Generally, LA deals with the development of methods that harness educational data sets to support the learning process. This paper provides a foundation for future research in LA. It provides a systematic overview on this emerging field and its key concepts through a reference model for LA based on four dimensions, namely data, environments, context (what?, stakeholders (who?, objectives (why?, and methods (how?. It further identifies various challenges and research opportunities in the area of LA in relation to each dimension.
陈光文; 乐军; 袁权
Gas-liquid microreaction technology has shown great potential in a variety of industrial relevant mass transfer operations and reactions.ThiS paper outlines the current research Status of this technology with emphasis on reactor design,hydrodynamics and mass transfer phenomena as well as reaction applications.The future chal-lenzes of this important technology are also suminarlzeo.
Kimmel, Kurt R.
Mask technology development has accelerated dramatically in recent years from the glacial pace of the last three decades to the rapid and sometimes simultaneous introductions of new wavelengths and mask-based resolution enhancement techniques. The nature of the semiconductor business has also become one driven by time-to-market as an overwhelming factor in capturing market share and profit. These are among the factors that have created enormous stress on the mask industry to produce masks with enhanced capabilities, such as phase-shifting attenuators, sub-resolution assist bars, and optical proximity correction (OPC) features, while maintaining or reducing cost and cycle time. The mask can no longer be considered a commodity item that is purchased form the lowest-cost supplier. Instead, it must now be promoted as an integral part of the technical and business case for a total lithographic solution. Improving partnership between designer, mask-maker, and wafer lithographer will be the harbinger of success in finding a profitable balance of capability, cost, and cycle time. Likewise for equipment infrastructure development, stronger partnership on the international level is necessary to control development cost and mitigate schedule and technical risks.
Developments in detector technologies aimed at solving challenges in present and future CERN experiments, particularly at the LHC, have triggered exceptional advances in the performance of medical imaging devices, allowing for a spectacular progress in in-vivo molecular imaging procedures, which are opening the way for tailored therapies of major diseases. This talk will briefly review the recent history of this prime example of technology transfer from HEP experiments to society, will describe the technical challenges being addressed by some ongoing projects, and will present a few new ideas for further developments and their foreseeable impact.
Liddicoat, Anthony J.
Considers the future challenges for languages in Australia. Discusses the place of language in policy, the place of languages in the curriculum, the role of professional associations, and redeveloping a constituency for languages. (Author/VWL)
Hai Jin; Li-Jun Hou; Xiao-Bing Fu
There has been no large-scale naval combat in the last 30 years. With the rapid development of battleships, weapons manufacturing and electronic technology, naval combat will present some new characteristics. Additionally, naval combat is facing unprecedented challenges. In this paper, we discuss the topic of medical rescue at sea: what chal-lenges we face and what we could do. The contents discussed in this paper contain battlefield self-aid buddy care, clinical skills, organized health services, medical training and future medical research programs. We also discuss the characteristics of modern naval combat, medical rescue challenges, medical treatment highlights and future develop-ments of medical rescue at sea.
White, C. E.
An important feature of many brokers is to facilitate straightforward human access to scientific data while maintaining programmatic access to it for system solutions. Standards-based protocols are critical for this, and there are a number of protocols to choose from. In this discussion, we will present a web application solution that leverages certain protocols - e.g., OGC CSW, REST, and OpenSearch - to provide programmatic as well as human access to geospatial resources. We will also discuss managing resources to reduce duplication yet increase discoverability, federated search solutions, and architectures that combine human-friendly interfaces with powerful underlying data management. The changing requirements witnessed in brokering solutions over time, our recent experience participating in the EarthCube brokering hack-a-thon, and evolving interoperability standards provide insight to future technological and philosophical directions planned for geospatial broker solutions. There has been much change over the past decade, but with the unprecedented data collaboration of recent years, in many ways the challenges and opportunities are just beginning.
Brilha, J. B.
During the last two decades, geoconservation has been gradually entering into the geosciences’ community. Recently, Henriques et al. (2011) presented a theoretical framework justifying geoconservation as an emerging geoscience. Geological heritage – materialized in geosites properly managed – establishes multiple links with the society. In spite of this general positive trend, geoconservation faces some future challenges.
Energy costs – Inefficient processes – Supply chain risk • Reduced Liability – Environmental and occupational • Increased Availability...2013 Noblis, Inc. Advancing Sustainable Surface Engineering: Challenges & Future Opportunities Dr. Jeffrey Marqusee Chief Scientist...control number. 1. REPORT DATE NOV 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Advancing Sustainable
This paper provides an update and extension of a 2006 paper, “Some Future Trends and Implications for Systems and Software Engineering Processes,” Systems Engineering, Spring 2006. Some of its challenges and opportunities are similar, such as the need to simultaneously achieve high levels of both agility and assurance. Others have emerged as increasingly important, such as the challenges of dealing with ultralarge volumes of data, with multicore chips, and with software as a service. The paper is organized around eight relatively surprise-free trends and two “wild cards” whose trends and implications are harder to foresee. The eight surprise-free trends are:
Hadi H. Alyami
Full Text Available Global energy demand is steadily increasing each year. Many jurisdictions are seeking to incorporate sustainable and renewable energy sources to help meeting the demand and doing so in a responsible method to the environment and the next generation. In a wide-context, renewable energy sources are promising, yet cannot be controlled in such a way that is responsive to energy demand fluctuation. Liquid Air Energy Storage (LAES technology seeks to bridge the gap that exists between energy supply and demand in an effort to mitigate the current demand deficiency. The volume ratio of air to liquid air is nearly 700:1. Liquid air is a dense energy carrier that is by converting renewable energy at off-peak periods into liquid air the energy can be stored until a peak-demand period when energy producers are maximising output to meet the demand. The energy is then retrieved from the liquid air through rapid expansion as it re-gasifies through a gas turbine and converted into electricity. A commercial scale pilot plant in Slough, UK illustrates the application of this technology empirically. The application of this technology in Canada might have challenges as public policy respective jurisdictions play a role. A case of point of applications where LAES can be integrated is the renewable energy market; particularly the wind power in Alberta. This paper’s analysis embraces wind power industry in Alberta from the perspective of both the electric system operator and the power generation plant. As such, it serves as an alleviating proposal of the current wind energy issues in Alberta – including the uncertainty of forecasting system. The analysis assumed energy storage technologies as a viable stand-alone mitigation with no consideration of the current technological and operational advancements in power systems such HVDC grids, distributed generation concepts and among others.
This paper presents NASA's recent direction to invest in the critical science instrument and platform technologies in order to realize more reliable, frequent and versatile missions for future Earth Science measurements. Historically, NASA's Earth Science Enterprise has developed and flown science missions that have been large in size, mass and volume. These missions have taken much longer to implement due to technology development time, and have carried a large suite of instruments on a large spacecraft. NASA is now facing an era where the budget for the future years is more or less flat and the possibility for any major new start does not vividly appear on the horizon. Unfortunately, the scientific measurement needs for remote sensing have not shrunk to commensurate with the budget constraints. In fact, the challenges and scientific appetite in search of answers to a score of outstanding questions have been gradually expanding. With these factors in mind, for the last three years NASA has been changing its focus to concentrate on how to take advantage of smaller missions by relying on industry, and minimizing the overall mission life cycle by developing technologies that are independent of the mission implementation cycle. The major redirection of early investment in the critical technologies should eventually have its rewards and significantly reduce the mission development period. Needless to say, in the long run this approach should save money, minimize risk, promote or encourage partnering, allow for a rapid response to measurement needs, and enable frequent missions making a wider variety of earth science measurements. This paper gives an overview of some of the identified crucial technologies and their intended applications for meeting the future Earth Science challenges.
Roby, W.; Wu, X.; Goldina, T.; Joliet, E.; Ly, L.; Mi, W.; Wang, C.; Zhang, Lijun; Ciardi, D.; Dubois-Felsmann, G.
At IPAC/Caltech, we have developed the Firefly web archive and visualization system. Used in production for the last eight years in many missions, Firefly gives the scientist significant capabilities to study data. Firefly provided the first completely web based FITS viewer as well as a growing set of tabular and plotting visualizers. Further, it will be used for the science user interface of the LSST telescope which goes online in 2021. Firefly must meet the needs of archive access and visualization for the 2021 LSST telescope and must serve astronomers beyond the year 2030. Recently, our team has faced the fact that the technology behind Firefly software was becoming obsolete. We were searching for ways to utilize the current breakthroughs in maintaining stability, testability, speed, and reliability of large web applications, which Firefly exemplifies. In the last year, we have ported the Firefly to cutting edge web technologies. Embarking on this massive overhaul is no small feat to say the least. Choosing the technologies that will maintain a forward trajectory in a future development project is always hard and often overwhelming. When a team must port 150,000 lines of code for a production-level product there is little room to make poor choices. This paper will give an overview of the most modern web technologies and lessons learned in our conversion from GWT based system to React/Redux based system.
Whitney, A. R.
Three technology areas are examined to measure their impact on VLBI and the capa bilities that may be offered to VLBI practioners in the near future: VLBI Standard Interface: An international committee has recently agr eed on a standard interface definition for all future VLBI data systems. This s hould, at long last, allow interoperability between various VLBI data systems. New Recording Technologies: Courtesy of large investments by the co mputer industry, moderately priced high-data rate digital recorders that may be suitable for VLBI are on the near horizon. Small arrays of these machines, appr opriately interfaced, promise to support 1-8 Gbps recording over the next few ye ars at an attractive price. e-VLBI: With the advent of optical fiber being laid at a prodigious rate, real-time (or near-real time) VLBI on an international scale is close to b eing a technical possibility. However, questions remain about costs to lease th e necessary bandwidth and to lay the 'last mile' of fiber to remote antennas.
The development of radiation detectors in the field of nuclear and particle physics has had a terrific impact in medical imaging since this latter discipline took off in late ’70 with the invention of the CT scanners. The massive use in High Energy Physics of position sensitive gas detectors, of high Z and high density scintillators coupled to Photomultiplier (PMT) and Position Sensitive Photomultipliers (PSPMT), and of solid state detectors has triggered during the last 30 years a series of novel applications in Medical Imaging with ionizing radiation. The accelerated scientific progression in genetics and molecular biology has finally generated what it is now called Molecular Imaging. This field of research presents additional challenges not only in the technology of radiation detector, but more and more in the ASIC electronics, fast digital readout and parallel software. In this series of three lectures I will try to present how high energy physics and medical imaging development have both benefited by t...
Espay, Alberto J; Bonato, Paolo; Nahab, Fatta B; Maetzler, Walter; Dean, John M; Klucken, Jochen; Eskofier, Bjoern M; Merola, Aristide; Horak, Fay; Lang, Anthony E; Reilmann, Ralf; Giuffrida, Joe; Nieuwboer, Alice; Horne, Malcolm; Little, Max A; Litvan, Irene; Simuni, Tanya; Dorsey, E Ray; Burack, Michelle A; Kubota, Ken; Kamondi, Anita; Godinho, Catarina; Daneault, Jean-Francois; Mitsi, Georgia; Krinke, Lothar; Hausdorff, Jeffery M; Bloem, Bastiaan R; Papapetropoulos, Spyros
The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.
Our future deep-space exploration faces many daunting challenges, but three of them loom high above the rest: physiological debilitation, radiation sickness and psychological stress. Many measures are presently being developed to reduce these difficulties. However, in the long run, two important new developments are required: abundant supply of power, and advanced space propulsion. The future looks bright, however. While the road is a long one, it is now well defined and many exciting explorations are within near-term reach.BiographyDr. Chang-Diaz graduated from MIT in the field of applied plasma physics and fusion research. He has been a NASA space shuttle astronaut on seven missions between 1986 and 2002. As director of the ASP Laboratory in Houston, he continues research on plasma rockets.For more details: see www.jsc.nasa.gov/Bios/htmlbios/chang.htmlNote: Tea and coffee will be served at 16:00 hrs.
Full Text Available In this review paper the present status of coastal lagoon and future challenges which will be faced by the coastal lagoon is discussed. Coastal lagoon provides great livelihood for a larger portion of human population through fisheries and tourism point of view thus crucial in socio economic aspect. Due to natural and anthropogenic activity, stress on coastal lagoon is increasing day by day. Thus steps should be taken for regular monitoring and planning for better management is found to be imperative in regards to present day situation.
Chandra, Ashish; Stroube, William B; Willis, William K
A rehabilitation center is another form of health care organization that specializes in providing care for particular conditions of patients. Patients admitted in rehab centers range from being accident victims to those suffering with a specific illness. These organizations are becoming extremely valuable in providing patient care services. However, they have not marketed themselves as aggressively as other health care organizations. This article provides an insight regarding rehab centers and examines marketing issues using a SWOT (strengths, weaknesses, opportunities, and threats) analysis. It further provides some future prospects and challenges for marketers of these organizations.
Bettin, Paolo; Di Matteo, Federico
The authors indicate four key issues which, in their opinion, represent the most stimulating challenges in the field of glaucoma today, and describe the present approaches and the developments that can be expected or advised in the near future: (1) Glaucoma is often undiagnosed or diagnosed too late. Accurate detection is crucial to correctly recognize and treat affected subjects, thus reducing the disability and the social burden of the disease. Is glaucoma screening advisable and cost-effective? What strategies can be implemented to achieve an earlier diagnosis? (2) What role can genetics play in glaucoma clinics? (3) What are the fundamentals and the limits of medical hypotensive and nonhypotensive treatment of glaucoma today, and what novelties could be introduced in the next few years? (4) What are the current and future options for glaucoma surgery? Should we aim at reducing aqueous production or at enhancing aqueous outflow? What are the success figures and the pros and cons of ab externo procedures with external filtration (trabeculectomy, nonpenetrating techniques and glaucoma drainage devices) and of ab externo techniques with internal filtration (viscocanalostomy and canaloplasty)? Will microinvasive procedures ever play a role in the treatment of the disease? These questions and the possible future developments in the management of glaucoma are discussed critically, based on the current clinical state of the art, on a review of the literature, and on an everyday experience in a busy university hospital glaucoma service.
Preuster, Patrick; Alekseev, Alexander; Wasserscheid, Peter
Future energy systems will be determined by the increasing relevance of solar and wind energy. Crude oil and gas prices are expected to increase in the long run, and penalties for CO2 emissions will become a relevant economic factor. Solar- and wind-powered electricity will become significantly cheaper, such that hydrogen produced from electrolysis will be competitively priced against hydrogen manufactured from natural gas. However, to handle the unsteadiness of system input from fluctuating energy sources, energy storage technologies that cover the full scale of power (in megawatts) and energy storage amounts (in megawatt hours) are required. Hydrogen, in particular, is a promising secondary energy vector for storing, transporting, and distributing large and very large amounts of energy at the gigawatt-hour and terawatt-hour scales. However, we also discuss energy storage at the 120-200-kWh scale, for example, for onboard hydrogen storage in fuel cell vehicles using compressed hydrogen storage. This article focuses on the characteristics and development potential of hydrogen storage technologies in light of such a changing energy system and its related challenges. Technological factors that influence the dynamics, flexibility, and operating costs of unsteady operation are therefore highlighted in particular. Moreover, the potential for using renewable hydrogen in the mobility sector, industrial production, and the heat market is discussed, as this potential may determine to a significant extent the future economic value of hydrogen storage technology as it applies to other industries. This evaluation elucidates known and well-established options for hydrogen storage and may guide the development and direction of newer, less developed technologies.
Current status and future perspectives of electron interactions with molecules, clusters, surfaces, and interfaces [Workshop on Fundamental challenges in electron-driven chemistry; Workshop on Electron-driven processes: Scientific challenges and technological opportunities
Becker, Kurt H.; McCurdy, C. William; Orlando, Thomas M.; Rescigno, Thomas N.
This report is based largely on presentations and discussions at two workshops and contributions from workshop participants. The workshop on Fundamental Challenges in Electron-Driven Chemistry was held in Berkeley, October 9-10, 1998, and addressed questions regarding theory, computation, and simulation. The workshop on Electron-Driven Processes: Scientific Challenges and Technological Opportunities was held at Stevens Institute of Technology, March 16-17, 2000, and focused largely on experiments. Electron-molecule and electron-atom collisions initiate and drive almost all the relevant chemical processes associated with radiation chemistry, environmental chemistry, stability of waste repositories, plasma-enhanced chemical vapor deposition, plasma processing of materials for microelectronic devices and other applications, and novel light sources for research purposes (e.g. excimer lamps in the extreme ultraviolet) and in everyday lighting applications. The life sciences are a rapidly advancing field where the important role of electron-driven processes is only now beginning to be recognized. Many of the applications of electron-initiated chemical processes require results in the near term. A large-scale, multidisciplinary and collaborative effort should be mounted to solve these problems in a timely way so that their solution will have the needed impact on the urgent questions of understanding the physico-chemical processes initiated and driven by electron interactions.
Robinson, Laura F; Siddall, Mark
The ocean interacts with the atmosphere, biosphere and cryosphere in a complex way, modulating climate through the storage and transport of heat, nutrients and carbon. As such, it is important that we understand the ways in which the ocean behaves and the factors that can lead to change. In order to gain this understanding, we need to look back into the past, on time scales from recent decadal-scale change, through the abrupt changes of the Pleistocene and back to times when the Earth's climate was significantly different than the Holocene. A key challenge facing the field of palaeoceanography is to combine data and modelling in a common framework. Coupling palaeo-data and models should improve our knowledge of how the Earth works, and perhaps of more direct societal relevance, might enable us to provide better predictive capabilities in climate modelling. In this discussion paper, we examine the motivations, past successes and challenges facing palaeoceanographic studies. We then suggest a number of areas and approaches that we believe will allow palaeoceanography to continue to provide new insights into processes that affect future climate change.
Full Text Available Pratibha Singhi, Arushi Gahlot SainiDepartment of Pediatrics, Pediatric Neurology and Neurodevelopment Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, IndiaAbstract: Neurocysticercosis (NCC is an acquired infection of the nervous system caused by encysted larvae of Taenia solium. It is a major cause of epilepsy in the tropics and the commonest cause of focal seizures in North Indian children. T. solium teniasis-cysticercosis is considered a parasitic “Neglected Tropical Diseases” endemic throughout Southeast Asia. NCC in children has pleomorphic manifestations depending on the location, number and viability of the cysts, and host response. Even with advancing knowledge of the disease manifestations, many aspects related to diagnosis and treatment, particularly in children, still remain controversial and pose challenges to clinical practice. There is no gold standard test to diagnose NCC and the management recommendations are still emerging. This review provides an overview of diagnosis of NCC in children and its management with special focus on current challenges and future prospects.Keywords: neurocysticercosis, children, epilepsy, ring enhancing lesions, pigs
Ozar, D T
While countries varies significantly in the financing of dental care, they are much more alike in the delivery of dentistry. Dental care is principally provided in dental offices and clinics that are independent business entities whose business leaders are most often the dentists themselves. However society expects from dentists a level of professionalism (i.e. habitually acting ethically, both in terms of competence and conduct) in contrast to the methods and motivations of the marketplace. This is why the single most important challenge of dental professional ethics continues to be giving proper priority to patients' well being and building ethically correct decision-making relationships with patients while, at the same time, trying to maintain a successful business operation. If we look into dentistry's future, the centrality of this aspect of professional ethics is not likely to change, although the ways in which dentists might violate this trust will probably multiple as funding mechanisms become increasingly complex. It is important that dentists reflect with fresh eyes on their ethical commitments. One challenge is the increased availability of oral health information to the public and the fact that so many people are uncritical of the accuracy of information in the media and on the web. A second is the increase in the amount of health care advertising in many societies. A third is the growth of aesthetic dentistry that differs from standard oral health care in important and ethically significant ways. The fourth is insurance that frequently complicates the explanation of a patient's treatment alternatives and often brings a third party into the treatment decision relationship. The ethical challenges of each of these factors will be considered and ultimately tying it to the central theme of dental professionalism.
Kourafalou, V. H.
Atmospheric OSSEs have had a much longer history of applications than OSSEs (and OSEs) in oceanography. Long standing challenges include the presence of coastlines and steep bathymetric changes, which require the superposition of a wide variety of space and time scales, leading to difficulties on ocean observation and prediction. For instance, remote sensing is critical for providing a quasi-synoptic oceanographic view, but the coverage is limited at the ocean surface. Conversely, in situ measurements are capable to monitor the entire water column, but at a single location and usually for a specific, short time. Despite these challenges, substantial progress has been made in recent years and international initiatives have provided successful OSSE/OSE examples and formed appropriate forums that helped define the future roadmap. These will be discussed, together with various challenges that require a community effort. Examples include: integrated (remote and in situ) observing system requirements for monitoring large scale and climatic changes, vs. short term variability that is particularly important on the regional and coastal spatial scales; satisfying the needs of both global and regional/coastal nature runs, from development to rigorous evaluation and under a clear definition of metrics; data assimilation in the presence of tides; estimation of real-time river discharges for Earth system modeling. An overview of oceanographic efforts that complement the standard OSSE methodology will also be given. These include ocean array design methods, such as representer-based analysis and adaptive sampling. Exciting new opportunities for both global and regional ocean OSSE/OSE studies have recently become possible with targeted periods of comprehensive data sets, such as the existing Gulf of Mexico observations from multiple sources in the aftermath of the DeepWater Horizon incident and the upcoming airborne AirSWOT, in preparation for the SWOT (Surface Water and Ocean
Antonella Del Rosso
Neutrons are among the fundamental building blocks of matter. Some of the processes in which they are involved are responsible for energy generation in nuclear power plants. In this context, CERN’s n_TOF and other facilities participating in the ERINDA EU-funded programme help the community integrate all the scientific efforts needed to produce high-quality nuclear data for future nuclear technologies. The 4π calorimeter inside the n_TOF experimental area. Image courtesy of the n_TOF Collaboration. Accurate measurements of the interactions between neutrons and each of the elements present in nuclear reactors are vital tools enabling scientists to explore solutions – other than simple protected storage – for the treatment of radioactive waste deriving from a number of applications, ranging from energy production to the medical field. Particularly valuable is the contribution provided by the 13 accelerator-based neutron sources, which the ERINDA EU-funded...
Bhagat, Pramode K.; Bessette, Lorence; Leonelli, Fredrick
Ever-increasing diversity of civilian aircraft inventory and continued technological advancements in aircraft materials, aircraft flight control equipment, testing equipment, and software methodologies are impacting aircraft inspection and maintenance practices. Current procedures deal mainly with issues related to structural and electrical or electronic integrity to assure continued airworthiness of operational aircraft. Techniques and methodologies for these are widely available, and training needs are well defined. Advances in technology, however, are yielding new and different aircraft, which require more sophisticated electronic instruments for navigation and control.A major issue is the continued reliability and airworthiness of avionics and development of adequate safeguards for these aircraft. Built-in test equipment, maintenance across terminals, and data bases defining inspection needs that are based on operational data, and software integrity, are also rapidly becoming important considerations in aircraft maintenance. In this era of declining funds and personnel resources, a cost-effective approach requires a fresh look at all phases of the current inspection and maintenance practices, including oversight and management. This paper provides a perspective on issues and challenges facing a civilian regulatory agency, specifically, the aircraft maintenance division in the FAA.
Pilat, Joseph F [Los Alamos National Laboratory; Budlong - Sylvester, Kory W [Los Alamos National Laboratory
For nearly two decades, the International Atomic Energy Agency (lAEA) has been transforming its safeguards system to address the challenges posed by undeclared nuclear programs, the associated revelation of an extensive non-State nuclear procurement network and other issues, including past limits to its verification mandate and the burden of noncompliance issues. Implementing the new measures, including those in the Additional Protocol, and integrating new and old safeguards measures, remains a work in progress. Implementation is complicated by factors including the limited teclmological tools that are available to address such issues as safeguarding bulk handling facilities, detection of undeclared facilities/activities, especially related to enrichment, etc. As this process continues, new challenges are arising, including the demands of expanding nuclear power production worldwide, so-called safeguards by design for a new generation of facilities, the possible IAEA role in a fissile material cutoff treaty and other elements of the arms control and disarmament agenda, the possible role in 'rollback' cases, etc. There is no doubt safeguards will need to evolve in the future, as they have over the last decades. In order for the evolutionary path to proceed, there will inter alia be a need to identify technological gaps, especially with respect to undeclared facilities, and ensure they are filled by adapting old safeguards technologies, by developing and introducing new and novel safeguards teclmologies and/or by developing new procedures and protocols. Safeguards will also need to respond to anticipated emerging threats and to future, unanticipated threats. This will require strategic planning and cooperation among Member States and with the Agency. This paper will address challenges to IAEA safeguards and the technological possibilities and R&D strategies needed to meet those challenges in the context of the forty-year evolution of safeguards, including
Pilat, Joseph F [Los Alamos National Laboratory; Budlong - Sylvester, Kory W [Los Alamos National Laboratory
For nearly two decades, the International Atomic Energy Agency (lAEA) has been transforming its safeguards system to address the challenges posed by undeclared nuclear programs, the associated revelation of an extensive non-State nuclear procurement network and other issues, including past limits to its verification mandate and the burden of noncompliance issues. Implementing the new measures, including those in the Additional Protocol, and integrating new and old safeguards measures, remains a work in progress. Implementation is complicated by factors including the limited teclmological tools that are available to address such issues as safeguarding bulk handling facilities, detection of undeclared facilities/activities, especially related to enrichment, etc. As this process continues, new challenges are arising, including the demands of expanding nuclear power production worldwide, so-called safeguards by design for a new generation of facilities, the possible IAEA role in a fissile material cutoff treaty and other elements of the arms control and disarmament agenda, the possible role in 'rollback' cases, etc. There is no doubt safeguards will need to evolve in the future, as they have over the last decades. In order for the evolutionary path to proceed, there will inter alia be a need to identify technological gaps, especially with respect to undeclared facilities, and ensure they are filled by adapting old safeguards technologies, by developing and introducing new and novel safeguards teclmologies and/or by developing new procedures and protocols. Safeguards will also need to respond to anticipated emerging threats and to future, unanticipated threats. This will require strategic planning and cooperation among Member States and with the Agency. This paper will address challenges to IAEA safeguards and the technological possibilities and R&D strategies needed to meet those challenges in the context of the forty-year evolution of safeguards, including
This article deals with topics where I expect special future challenges, exemplifying these by experiments out of my own department. One area where I expect large progress also in view of many technical developments in the past concerns the understanding of the structure of fluid interfaces at the atomic level. It is shown by non-linear optical spectroscopies that the free water surface is ice-like and can be "liquefied" by ion adsorption. X-ray fluorescence from the interface demonstrates that ion binding is very specific which cannot be explained by existing theories. A second major area are nonequilibrium features, and one of the old and new ones here is nucleation and growth. This presentation concentrates on effects produced by ultrasound, a well-defined trigger of gas bubble formation. It exhibits high potential for chemistry at extreme conditions but with a reactor at normal conditions. It has special importance for treatment of surfaces that can be also manipulated via controlled surface energies. A third area will concern complex and smart systems with multiple functions in materials and biosciences. As next generation, I anticipate those with feedback control, and examples on this are self-repairing coatings.
Grover, Atul; Orlowski, Janis M; Erikson, Clese E
There is much debate about the adequacy of the U.S. physician workforce and projections of its future size, distribution and composition. Beginning with 3 observations about the workforce we believe are largely not subject to dispute, we address the debate by providing an overview of the current state of the workforce and Graduate Medical Education in the United States; a brief history of both calls for graduate medical education reform since 1910 and the recent, intense debate about the reliability of workforce projections; and a discussion of the challenges to understanding the physician workforce. We draw 3 concluding observations: (1) Precisely because projections can be unpredictable in their impact on both physician workforce behavior and public policy development, policy makers need to devote more attention to workforce projections, not less. (2) More research devoted specifically to the workforce implications of delivery and payment reforms is strongly needed. (3) Such research must be pursued with a sense of urgency, given the rapid aging of the Baby Boom generation, which will put a disproportionate demand on the nation's physician workforce.
Sousa, Ricardo E; Costa, Carlos M; Lanceros-Méndez, Senentxu
There is an increasing interest in thin and flexible energy storage devices to meet modern society's needs for applications such as radio frequency sensing, interactive packaging, and other consumer products. Printed batteries comply with these requirements and are an excellent alternative to conventional batteries for many applications. Flexible and microbatteries are also included in the area of printed batteries when fabricated using printing technologies. The main characteristics, advantages, disadvantages, developments, and printing techniques of printed batteries are presented and discussed in this Review. The state-of-the-art takes into account both the research and industrial levels. On the academic level, the research progress of printed batteries is divided into lithium-ion and Zn-manganese dioxide batteries and other battery types, with emphasis on the different materials for anode, cathode, and separator as well as in the battery design. With respect to the industrial state-of-the-art, materials, device formulations, and manufacturing techniques are presented. Finally, the prospects and challenges of printed batteries are discussed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Hadi H. Alyami; Ryan Williams
Global energy demand is steadily increasing each year. Many jurisdictions are seeking to incorporate sustainable and renewable energy sources to help meeting the demand and doing so in a responsible method to the environment and the next generation. In a wide-context, renewable energy sources are promising, yet cannot be controlled in such a way that is responsive to energy demand fluctuation. Liquid Air Energy Storage (LAES) technology seeks to bridge the gap that exists between energy su...
smaller and leaner force structure. The DoD has employed such “offset strategies” in the past to compensate for other challenges to national security. Our...LRRDPP.html). So far, more than 300 “ideas” have been submitted. Emerging themes surround the use of autonomy , range and quantities at cost (the
Full Text Available Abstract.As Malaysia races against time to achieve Vision 2020 to be a developed nation, there is an urgent need for highly-skilled human resources to fulfill the requirements of the industry. This calls for an expansion of the engineering technology program to increase the number of technical graduates. However, various challenges are faced by the institutions in the implementation of the Engineering Technology programs, which have significant negative impact on the nation in general and in particular the graduates from the programs. Data was collected from a brainstorming session between six organizations involved in providing engineering technology education in Malaysia and the UniversitiTeknologi Malaysia (UTM and a convention on Engineering Technology Future in Malaysia. These challenges are categorized into four and discussed in this paper.Keywords: Accreditation, Challenges, Engineering technology; Human resources, Technical graduates.
Wu, Q. [Brookhaven National Lab. (BNL), Upton, NY (United States)
In two-ring facilities operating with a crossing-angle collision scheme, luminosity can be limited due to an incomplete overlapping of the colliding bunches. Crab cavities then are introduced to restore head-on collisions by providing the destined opposite deflection to the head and tail of the bunch. An increase in luminosity was demonstrated at KEKB with global crab-crossing, while the Large Hardron Collider (LHC) at CERN currently is designing local crab crossing for the Hi-Lumi upgrade. Future colliders may investigate both approaches. In this paper, we review the challenges in the technology, and the implementation of crab cavities, while discussing experience in earlier colliders, ongoing R&D, and proposed implementations for future facilities, such as HiLumi-LHC, CERN’s compact linear collider (CLIC), the international linear collider (ILC), and the electron-ion collider under design at BNL (eRHIC).
In two-ring facilities operating with a crossing-angle collision scheme, luminosity can be limited due to an incomplete overlapping of the colliding bunches. Crab cavities then are introduced to restore head-on collisions by providing the destined opposite deflection to the head and tail of the bunch. An increase in luminosity was demonstrated at KEKB with global crab- crossing, while the Large Hardron Collider (LHC) at CERN currently is designing local crab crossing for the Hi-Lumi upgrade. Future colliders may investigate both approaches. In this paper, we review the challenges in the technology, and the implementation of crab cavities, while discussing experience in earlier colliders, ongoing R&D, and proposed implementations for future facilities, such as HiLumi-LHC, CERN’s compact linear collider (CLIC), the international linear collider (ILC), and the electronion collider under design at BNL (eRHIC).
Ozbolat, Ibrahim T; Yu, Yin
Tissue engineering has been a promising field of research, offering hope for bridging the gap between organ shortage and transplantation needs. However, building three-dimensional (3-D) vascularized organs remains the main technological barrier to be overcome. Organ printing, which is defined as computer-aided additive biofabrication of 3-D cellular tissue constructs, has shed light on advancing this field into a new era. Organ printing takes advantage of rapid prototyping (RP) technology to print cells, biomaterials, and cell-laden biomaterials individually or in tandem, layer by layer, directly creating 3-D tissue-like structures. Here, we overview RP-based bioprinting approaches and discuss the current challenges and trends toward fabricating living organs for transplant in the near future.
VanderKaay, Sandra; Moll, Sandra E; Gewurtz, Rebecca E; Jindal, Pranay; Loyola-Sanchez, Adalberto; Packham, Tara L; Lim, Chun Y
Qualitative research has had a significant impact within rehabilitation science over time. During the past 20 years the number of qualitative studies published per year in Disability and Rehabilitation has markedly increased (from 1 to 54). In addition, during this period there have been significant changes in how qualitative research is conceptualized, conducted, and utilized to advance the field of rehabilitation. The purpose of this article is to reflect upon the progress of qualitative research within rehabilitation to date, to explicate current opportunities and challenges, and to suggest future directions to continue to strengthen the contribution of qualitative research in this field. Relevant literature searches were conducted in electronic data bases and reference lists. Pertinent literature was examined to identify current opportunities and challenges for qualitative research use in rehabilitation and to identify future directions. Six key areas of opportunity and challenge were identified: (a) paradigm shifts, (b) advancements in methodology, (c) emerging technology, (d) advances in quality evaluation, (e) increasing popularity of mixed methods approaches, and (f) evolving approaches to knowledge translation. Two important future directions for rehabilitation are posited: (1) advanced training in qualitative methods and (2) engaging qualitative communities of research. Qualitative research is well established in rehabilitation and has an important place in the continued growth of this field. Ongoing development of qualitative researchers and methods are essential. Implications for Rehabilitation Qualitative research has the potential to improve rehabilitation practice by addressing some of the most pervasive concerns in the field such as practitioner-client interaction, the subjective and lived experience of disability, and clinical reasoning and decision making. This will serve to better inform those providing rehabilitation services thereby benefiting
Dierker,S.; Bergmann, U.; Corlett, J.; Dierker, S.; Falcone, R.; Galayda, J.; Gibson, M.; Hastings, J.; Hettel, B.; Hill, J.; Hussain, Z.; Kao, C.-C.; Kirx, J.; Long, G.; McCurdy, B.; Raubenheimer, T.; Sannibale, F.; Seeman, J.; Shen, Z.-X.; Shenoy, g.; Schoenlein, B.; Shen, Q.; Stephenson, B.; Stohr, J.; Zholents, A.
Many of the important challenges facing humanity, including developing alternative sources of energy and improving health, are being addressed by advances that demand the improved understanding and control of matter. While the visualization, exploration, and manipulation of macroscopic matter have long been technological goals, scientific developments in the twentieth century have focused attention on understanding matter on the atomic scale through the underlying framework of quantum mechanics. Of special interest is matter that consists of natural or artificial nanoscale building blocks defined either by atomic structural arrangements or by electron or spin formations created by collective correlation effects. The essence of the challenge to the scientific community has been expressed in five grand challenges for directing matter and energy recently formulated by the Basic Energy Sciences Advisory Committee . These challenges focus on increasing our understanding of, and ultimately control of, matter at the level of atoms, electrons. and spins, as illustrated in Figure 1.1, and serve the entire range of science from advanced materials to life sciences. Meeting these challenges will require new tools that extend our reach into regions of higher spatial, temporal, and energy resolution. X-rays with energies above 10 keV offer capabilities extending beyond the nanoworld shown in Figure 1.1 due to their ability to penetrate into optically opaque or thick objects. This opens the door to combining atomic level information from scattering studies with 3D information on longer length scales from real space imaging with a resolution approaching 1 nm. The investigation of multiple length scales is important in hierarchical structures, providing knowledge about function of living organisms, the atomistic origin of materials failure, the optimization of industrial synthesis, or the working of devices. Since the fundamental interaction that holds matter together is of
Bergmann, Uwe; Corlett, John; Dierker, Steve; Falcone, Roger; Galayda, John; Gibson, Murray; Hastings, Jerry; Hettel, Bob; Hill, John; Hussain, Zahid; Kao, Chi-Chang; Kirz, Janos; Long, Danielle; McCurdy, Bill; Raubenheimer, Tor; Sannibale, Fernando; Seeman, John; Shen, Z. -X.; Schenoy, Gopal; Schoenlein, Bob; Shen, Qun; Stephenson, Brian; Stohr, Joachim; Zholents, Alexander
Many of the important challenges facing humanity, including developing alternative sources of energy and improving health, are being addressed by advances that demand the improved understanding and control of matter. While the visualization, exploration, and manipulation of macroscopic matter have long been technological goals, scientific developments in the twentieth century have focused attention on understanding matter on the atomic scale through the underlying framework of quantum mechanics. Of special interest is matter that consists of natural or artificial nanoscale building blocks defined either by atomic structural arrangements or by electron or spin formations created by collective correlation effects The essence of the challenge to the scientific community has been expressed in five grand challenges for directing matter and energy recently formulated by the Basic Energy Sciences Advisory Committee. These challenges focus on increasing our understanding of, and ultimately control of, matter at the level of atoms, electrons. and spins, as illustrated in Figure 1.1, and serve the entire range of science from advanced materials to life sciences. Meeting these challenges will require new tools that extend our reach into regions of higher spatial, temporal, and energy resolution. X-rays with energies above 10 keV offer capabilities extending beyond the nanoworld shown in Figure 1.1 due to their ability to penetrate into optically opaque or thick objects. This opens the door to combining atomic level information from scattering studies with 3D information on longer length scales from real space imaging with a resolution approaching 1 nm. The investigation of multiple length scales is important in hierarchical structures, providing knowledge about function of living organisms, the atomistic origin of materials failure, the optimization of industrial synthesis, or the working of devices. Since the fundamental interaction that holds matter together is of
Wolf, Milton, Ed.; And Others
Includes two articles that discuss science fiction and future possibilities in information technology: "'Jurassic Park' and Al Jolson: Thinking about the Information Revolution" (Connie Willis) and "The Good and the Bad: Outlines of Tomorrow" (David Brin). (LRW)
The jet engine is the prime flight controller in post-stall flight domains where conventional flight control fails, or when the engine prevents catastrophes in training, combat, loss of all airframe hydraulics (the engine retains its own hydraulics), loss of one engine, pilot errors, icing on the wings, landing gear and runway issues in takeoff and landing and in bad-whether recoveries. The scientific term for this revolutionary technology is "jet-steering", and in engineering practice - "thrust vectoring", or "TV". Jet-Steering in advanced fighter aircraft designs is integrated with stealth technology. The resulting classified Thrust-Vectoring-Stealth ("TVS") technology has generated a second jet-revolution by which all Air-&-Sea-Propulsion Science and R&D are now being reassessed. Classified F-22, X-47B/C and RQ-180 TVS-vehicles stand at the front of this revolution. But recent transfers of such sensitive technologies to South Korea and Japan [1-5], have raised various fundamental issues that are evaluated by this editorial-review. One, and perhaps a key conclusion presented here, means that both South Korea and Japan may have missed one of their air-&-sea defenses: To develop and field low-cost unmanned fleets of jet-drones, some for use with expensive, TVS-fighter aircraft in highly congested areas. In turn, the U.S., EU, Russia and China, are currently developing such fleets at various TVS levels and sizes. China, for instance, operates at least 15,000 drones ("UAVs") by 2014 in the civilian sector alone. All Chinese drones have been developed by at least 230 developers/manufacturers [1-16]. Mobile telecommunication of safe links between flyers and combat drones ("UCAVs") at increasingly deep penetrations into remote, congested areas, can gradually be purchased-developed-deployed and then operated by extant cader of tens of thousands "National Champion Flyers" who have already mastered the operation of mini-drones in free-to-all sport clubs under national
Lampert, C. M.
This paper begins with the history of electrochromism, first discovered in the 1880's. The physics, electrochemistry, device design and materials are covered. The science of electrochromism involves the coloration of a variety of metal oxides, organics and polymers. Dual ion and electron intercalation is used to color and bleach electrochromic materials. Considerable science has been undertaken to make devices that resemble thin film transparent batteries in their structure. A number of materials have been developed to make layers for electrochromic devices. Applications for electrochromics include low information content displays, such as banner displays, smart windows and mirrors for automotive applications. Several companies throughout the world are developing dynamic glazing. Switchable glazing for building and vehicle application is very attractive for energy and light management. From the standpoint of materials much research and development in electrochromics focuses on the development or improvement of materials with ionic and electronic properties. Much of the work on electrochromics draws on the vast knowledge developed for advanced batteries. National Laboratory and university groups are researching new materials and processes to improve electrochromic materials. Also, much industrial work is directed towards deposition and fabrication processes for glass and possibly plastic that can make electrochromics cost effective. Plastic can yield both flexibility and weight savings for many applications. Although plastics are permeable, outgas and require lower processing temperatures, they can be more universally applied. Some developments in plastics may come from OLED sealing technology. Comparisons are made between the properties of electrochromics and other switchable technologies. Technology comparisons are made between suspended particles, polymer dispersed liquid crystals, themotropics and gas-chromics.
Advanced jet engines do not operate in an application vacuum. Their optimal use in advanced military applications drives much of their basic innovative research and development, especially when new needs arise in the rapidly changing domains of stealth-agile, fighter aircraft and tailless-stealth, Jet-Steered, Unmanned Air Vehicles (JS-UAV). For these reasons we periodically update this Journal with new trends that affect, and sometimes control, research and development of future jet-engines. One relevant example is the recently unmasked RQ-180 stealth-tailless drone, which is an improved version of the smaller, RQ-170 captured by Iran. Most important, with the new X-47B/C tailless-stealth JS-UAV, it is to dominate future uses of fuel-efficient jet-engines, especially for operating in dusty environments. The RQ-180 has been secretly designed and funded since 2008. It is based on a classified, 1986, parent Israeli Patents 78402, which protect hundreds design and testing trade secrets taken from 1986 to 1997 by the United States Government (USG) via classified contracts with USG-Contractors Boeing, Lockheed, General Dynamics and General Electric, as revealed by a December 6, 2013 Aviation Week [1-3] and U.S. Court of Appeals for the Federal Circuit, Case 2014-5028, Docket 12 . The new RQ-180 design explains the recent U.S. Air Force ISR shift away from "permissive" environments - such as Iraq and Afghanistan, where non-stealthy Global Hawk and General Atomics' Reaper operate - toward new missions in highly "contested" or strongly "denied" enemy airspaces.
Alders, Amanda; Beck, Liz; Allen, Pat B.; Mosinski, Barbara
As technology advances, art therapy practices are adapting to the demands of a new cultural climate. Art therapists face a number of ethical challenges as they interact with increasingly diverse populations and employ new media. This article addresses some of the ethical and professional issues related to the use of technology in clinical…
Alders, Amanda; Beck, Liz; Allen, Pat B.; Mosinski, Barbara
As technology advances, art therapy practices are adapting to the demands of a new cultural climate. Art therapists face a number of ethical challenges as they interact with increasingly diverse populations and employ new media. This article addresses some of the ethical and professional issues related to the use of technology in clinical…
This updated, PART C REVIEW, covers the dangerous global spread of JS-stealth, drone technology [1-91], canard-free, stealth, new agile drones and the highly debated, 480 billion F-35 International Program as reported on March 13, 2013 to the U.S. Congress . Due to serious design issues, spiraling high costs and years in delays, alternatives are analyzed here, depicted and proposed, mainly from the propulsion-design point of view. These include fleets of low-cost, stealth, jet-steered-drones mixed with non-stealthy, low-cost, ready-to-be-delivered, U.S. or European or Russian fighter aircraft. Can a few F-35s win against large fleets of stealth agile drones? To understand the dangers and critical issues involved, the author's own, past classified information is partly disclosed, while resorting to images in Figs. 2(a) and 2(b) taken from his book  and from Wikipedia, the "Free Encyclopedia", in all other images.
Full Text Available Healthcare changes dramatically because of technological developments, from anesthetics and antibiotics to magnetic resonance imaging scanners and radiotherapy. Future technological innovation is going to keep transforming healthcare, yet while technologies (new drugs and treatments, new devices, new social media support for healthcare, etc will drive innovation, human factors will remain one of the stable limitations of breakthroughs. No predictions can satisfy everybody; instead, this article explores fragments of the future to see how to think more clearly about how to get where we want to go.
Brandhorst, Henry W., Jr.
The future appears rich in missions that will extend the frontiers of knowledge, human presence in space, and opportunities for profitable commerce. The key to success of these ventures is the availability of plentiful, cost effective electric power and assured, low cost access to space. While forecasts of space power needs are problematic, an assessment of future needs based on terrestrial experience was made. These needs fall into three broad categories-survival, self sufficiency and industrialization. The cost of delivering payloads to orbital locations from low earth orbit (LEO) to Mars was determined and future launch cost reductions projected. From these factors, then, projections of the performance necessary for future solar and nuclear space power options were made. These goals are largely dependent upon orbital location and energy storage needs.
Peace/ Colombia Scenario " Features of this Future "* Spread of democracy eliminates risk of wars "* EU, China, Japan economic, but not political, U.S...multinational effort to restore order to Bogota, Colombia , led by the U.S. Army. This would follow extensive and debilitating urban conflict between...Egypt Civil War Scenario . Features of this Future "* Nation-states destroyed in several regions by overpopulation , environmental degradation, ethnic
Computing of the future will be affected by a number of fundamental technologies in development today, many of which are already on the way to becoming commercialized. In this series of lectures, we will discuss hardware and software development that will become mainstream in the timeframe of a few years and how they will shape or change the computing landscape - commercial and personal alike. Topics range from processor and memory aspects, programming models and the limits of artificial intelligence, up to end-user interaction with wearables or e-textiles. We discuss the impact of these technologies on the art of programming, the data centres of the future and daily life. On the second day of the Future Computing Technology series, we will talk about ubiquitous computing. From smart watches through mobile devices to virtual reality, computing devices surround us, and innovative new technologies are introduces every day. We will briefly explore how this propagation might continue, how computers can take ove...
Issues currently affecting employee training are the impact of high technology, worker adaptability, the communications revolution, job satisfaction, underinvestment in human capital, demographic shifts, and interest in productivity improvement. (SK)
Andreassen, Christian Nicolaj; Schack, Line Meinertz Hybel; Laursen, Louise Vagner;
. These strategies include 'big data approaches' and collaborative research within international consortia. Furthermore, research that combines the study of radiation-induced gene expression and genome-wide SNP genotype may discover genetic alterations that regulate the biological response to ionizing radiation...... to side effects after radiotherapy. Despite this, certain fundamental challenges still relate to genomic approaches. Based on the latest insights into complex trait genetics and molecular genetics, we provide an analysis of these challenges and propose putative strategies to further advance the field...
2005-2006 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 12, 13, 14, 15 and 16 June 11:00-12:00 - Auditorium, bldg 500 Technological challenges of CLIC R. Corsini, S. Doebert, S. Redaelli, T.Lefevre, CERN-AB and G. Arnau Izquierdo, H. Mainaud, CERN-TS Future e+e- Linear Colliders offer the potential to explore new physics at the TeV scale and beyond to very high precision. While the International Linear Collider (ILC) scheme of a collider in the 0.5 - 1 TeV range enters the engineering design phase, the Compact Linear Collider (CLIC) study explores the technical feasibility of a collider capable of reaching into the multi-TeV energy domain. Key ingredients of the CLIC scheme are acceleration at high-frequency (30 GHz) and high-gradient (150 MV/m) in normal conducting structures and the use of the so-called Two Beam Acceleration concept, where a high-charge electron beam (drive beam) running parallel to the main beam is decelerated to provide the RF power to accelerate the main beam itself. A vigorous R&...
Khan, Nawsher; Yaqoob, Ibrar; Hashem, Ibrahim Abaker Targio; Inayat, Zakira; Mahmoud Ali, Waleed Kamaleldin; Alam, Muhammad; Shiraz, Muhammad; Gani, Abdullah
Big Data has gained much attention from the academia and the IT industry. In the digital and computing world, information is generated and collected at a rate that rapidly exceeds the boundary range. Currently, over 2 billion people worldwide are connected to the Internet, and over 5 billion individuals own mobile phones. By 2020, 50 billion devices are expected to be connected to the Internet. At this point, predicted data production will be 44 times greater than that in 2009. As information is transferred and shared at light speed on optic fiber and wireless networks, the volume of data and the speed of market growth increase. However, the fast growth rate of such large data generates numerous challenges, such as the rapid growth of data, transfer speed, diverse data, and security. Nonetheless, Big Data is still in its infancy stage, and the domain has not been reviewed in general. Hence, this study comprehensively surveys and classifies the various attributes of Big Data, including its nature, definitions, rapid growth rate, volume, management, analysis, and security. This study also proposes a data life cycle that uses the technologies and terminologies of Big Data. Future research directions in this field are determined based on opportunities and several open issues in Big Data domination. These research directions facilitate the exploration of the domain and the development of optimal techniques to address Big Data. PMID:25136682
Full Text Available Big Data has gained much attention from the academia and the IT industry. In the digital and computing world, information is generated and collected at a rate that rapidly exceeds the boundary range. Currently, over 2 billion people worldwide are connected to the Internet, and over 5 billion individuals own mobile phones. By 2020, 50 billion devices are expected to be connected to the Internet. At this point, predicted data production will be 44 times greater than that in 2009. As information is transferred and shared at light speed on optic fiber and wireless networks, the volume of data and the speed of market growth increase. However, the fast growth rate of such large data generates numerous challenges, such as the rapid growth of data, transfer speed, diverse data, and security. Nonetheless, Big Data is still in its infancy stage, and the domain has not been reviewed in general. Hence, this study comprehensively surveys and classifies the various attributes of Big Data, including its nature, definitions, rapid growth rate, volume, management, analysis, and security. This study also proposes a data life cycle that uses the technologies and terminologies of Big Data. Future research directions in this field are determined based on opportunities and several open issues in Big Data domination. These research directions facilitate the exploration of the domain and the development of optimal techniques to address Big Data.
Baffa, C.; Giani, E.; Vrcic, S.; Vela Nuñez, M.
The Square Kilometer Array (SKA) project is an international effort to build the world's largest radio telescope, with eventually over a square kilometer of collecting area. For SKA Phase 1, Australia will host the low-frequency instrument with more than 500 stations, each containing around 250 individual antennas, whilst South Africa will host an array of close to 200 dishes. The scale of the SKA represents a huge leap forward in both engineering and research and development towards building and delivering a unique instrument, with the detailed design and preparation now well under way. As one of the largest scientific endeavors in history, the SKA will brings together close to 100 organizations from 20 countries. Every aspect of the design and development of such a large and complex instrument requires state-of-the-art technology and innovative approach. This poster (or paper) addresses some aspects of the SKA monitor and control system, and in particular describes the development and test results of the CSP Local Monitoring and Control prototype. At the SKA workshop held in April 2015, the SKA monitor and control community has chosen TANGO Control System as a framework, for the implementation of the SKA monitor and control. This decision will have a large impact on Monitor an Control development of SKA. As work is on the way to incorporate TANGO Control System in SKA is in progress, we started to development a prototype for the SKA Central Signal Processor to mitigate the associated risks. In particular we now have developed a uniform class schema proposal for the sub-Element systems of the SKA-CSP.
Fruehan, R.J.; Paxton, H.W.; Giarratani, F.; Lave, L. [Carnegie-Mellon Univ., Pittsburgh, PA (United States)]|[Pittsburgh Univ., PA (United States)
The objective of this report is to develop a vision of the future steelmaking industry including its general characteristics and technologies. In addition, the technical obstacles and research and development opportunities for commercialization of these technologies are identified. The report is being prepared by the Sloan Steel Industry Competitiveness Study with extensive input from the industry. Industry input has been through AISI (American Iron and Steel Institute), SMA (Steel Manufacturers Association) and contacts with individual company executives and technical leaders. The report identifies the major industry drivers which will influence technological developments in the industry for the next 5--25 years. Initially, the role of past drivers in shaping the current industry was examined to help understand the future developments. Whereas this report concentrates on future technologies other major factors such as national and international competition, human resource management and capital concerns are examined to determine their influence on the future industry. The future industry vision does not specify specific technologies but rather their general characteristics. Finally, the technical obstacles and the corresponding research and development required for commercialization are detailed.
This paper reviews the development of manufacturing technology and the progress that has so far been made in this field.It points out that manufacturing technology is not only the pillar of material civilization and the base of spiritual civilization of man,but also the foundation of a country's competitivendess.The paper also attempts to review the future of manufacturing technology through the description of the new pattern of manufacturing market,new features of manufactured products,new characteristics of technologies as well as the emerging trends of manufacturing enterprises and man-agement in the 21 st cetury.
Full Text Available Maintaining a healthy ecosystem is essential for maximizing sustainable ecological services of the best quality to human beings. Ecological and conservation research has provided a strong scientific background on identifying ecological health indicators and correspondingly making effective conservation plans. At the same time, ecologists have asserted a strong need for spatially explicit and temporally effective ecosystem health assessments based on remote sensing data. Currently, remote sensing of ecosystem health is only based on one ecosystem attribute: vigor, organization, or resilience. However, an effective ecosystem health assessment should be a comprehensive and dynamic measurement of the three attributes. This paper reviews opportunities of remote sensing, including optical, radar, and LiDAR, for directly estimating indicators of the three ecosystem attributes, discusses the main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system, and provides some future perspectives. The main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system are: (1 scale issue; (2 transportability issue; (3 data availability; and (4 uncertainties in health indicators estimated from remote sensing data. However, the Radarsat-2 constellation, upcoming new optical sensors on Worldview-3 and Sentinel-2 satellites, and improved technologies for the acquisition and processing of hyperspectral, multi-angle optical, radar, and LiDAR data and multi-sensoral data fusion may partly address the current challenges.
Li, Zhaoqin; Xu, Dandan; Guo, Xulin
Maintaining a healthy ecosystem is essential for maximizing sustainable ecological services of the best quality to human beings. Ecological and conservation research has provided a strong scientific background on identifying ecological health indicators and correspondingly making effective conservation plans. At the same time, ecologists have asserted a strong need for spatially explicit and temporally effective ecosystem health assessments based on remote sensing data. Currently, remote sensing of ecosystem health is only based on one ecosystem attribute: vigor, organization, or resilience. However, an effective ecosystem health assessment should be a comprehensive and dynamic measurement of the three attributes. This paper reviews opportunities of remote sensing, including optical, radar, and LiDAR, for directly estimating indicators of the three ecosystem attributes, discusses the main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system, and provides some future perspectives. The main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system are: (1) scale issue; (2) transportability issue; (3) data availability; and (4) uncertainties in health indicators estimated from remote sensing data. However, the Radarsat-2 constellation, upcoming new optical sensors on Worldview-3 and Sentinel-2 satellites, and improved technologies for the acquisition and processing of hyperspectral, multi-angle optical, radar, and LiDAR data and multi-sensoral data fusion may partly address the current challenges.
Bull, Alan T; Stach, James E M; Ward, Alan C; Goodfellow, Michael
In this paper we evaluate the current state of research on the biology and biotechnology of marine actinobacteria. The topics covered include the abundance, diversity, novelty and biogeographic distribution of marine actinobacteria, ecosystem function, bioprospecting, and a new approach to the exploration of actinobacterial taxonomic space. An agenda for future marine actinobacterial research is suggested based upon consideration of the above issues.
Osborn, R R
The AHRA has made considerable progress in the past few years in expanding its liaison activities to an international level. Mr. Osborn, the association's Coordinator for International Relations, traces the development of this effort and looks at goals and objectives for the future.
Fedrizzi, Mario; Kacprzyk, Janusz
This book provides readers with a timely and comprehensive yet concise view on the field of fuzzy logic and its real-world applications. The chapters, written by authoritative scholars in the field, report on promising new models for data analysis, decision making, and systems modeling, with a special emphasis on their applications in management science. The book is a token of appreciation from the fuzzy research community to Professor Christer Carlsson for his long time research and organizational commitment, which have among other things resulted in the foundation and success of the Institute for Advanced Management Systems Research (IAMSR) at Åbo Akademi University, in Åbo (Turku), Finland. The book serves as timely guide for the fuzzy logic and operations research communities alike. .
Archibald, Mandy M; Barnard, Alan
To explore the concept of futurism and the emergence of robotics in relation to the fundamentals of care, highlighting how nurses need a more anticipatory and contemporary position towards technology to maintain relevance in the future. The future of nursing in Western countries will soon be linked with the emergence of robotics for efficient and cost effective provision of fundamental care. Their emergence and roles with care of the body and more broadly assisting people with their daily living activities has enormous implications for the profession and health care. Despite this importance, how nursing understands and will respond to technological trends and developments is insufficiently reflected in the professions discourse. A discursive article METHODS: Literature from nursing fundamentals of care / fundamental care, information science, technology, humanities and philosophy informed the arguments in this paper. This paper examines the intersection of futurism and the fundamentals of care and how adopting an anticipatory and post-human perspective towards technological-care integration is necessary amidst a robot revolution in the techno-era. Nurses are currently challenged to understand, prioritize and deliver fundamental care. Health systems are challenged by a lack of care predicated by shortfalls in skilled staff and deficiencies in their mobilization. Both challenges can be compounded or alleviated by further integration of technology, but to maximize benefit requires forethought and understanding. This article can help open needed dialogue around planning for the future and is a call to action for the nursing profession to conceptualize their position on exponential technological growth and fundamental care provision. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Sinagra, Gianfranco; Fabris, Enrico; Tavazzi, Luigi
The field of cardiovascular medicine continues to rapidly evolve in both diagnostic and therapeutic arenas. Subspecialization is required to keep pace with evolving practice; however, a multidisciplinary approach in a framework of cost-benefit care will be equally crucial in the management of increasing numbers of complex patients. Information technology and translational medicine may radically change clinical research and practice. It is important to consider the evolution of medicine and reflect on it in order to set the right course to achieve patient-centered goals. Therefore, we present an overview of this evolving picture, a glimpse into the near future aimed at reflecting on the upcoming changes, challenges and opportunities to improve patient care.
William J Wall
Full Text Available Liver transplantation has evolved from a rare and risky operation of questionable therapeutic value to the preferred treatment for an extensive list of end-stage liver diseases. Superior immunosuppression (cyclosporine, and improvements in surgery and anesthesia brought liver grafting to its current level of success. Nearly 60,000 liver transplants have been performed, and survival rates are very good; however liver grafting faces serious immediate and long term challenges, mainly due to the widening gap between donor supply and recipient demand. Increasing numbers of sick candidates, recurrent disease (especially hepatitis C and recidivism rates after transplantation for alcoholic cirrhosis will force increasingly difficult decisions on candidate selection and priority listing of potential recipients. Although xenotransplantation may be the ultimate solution, it has its own specific set of biological and societal challenges - the full extent of which should be revealed in the next several years.
K. Jeferry; G. Kousiouris; D. Kyriazis; J. Altmann; A. Ciuffoletti; I. Maglogiannis; P. Nesi; B. Suzic; Z. Zhao
The cloud computing paradigm encompasses several key differentiating elements and technologies, tackling a number of inefficiencies, limitations and problems that have been identified in the distributed and virtualized computing domain. Nonetheless, and as it is the case for all emerging technologie
Allen, Douglas M.
The expansion of space requirements creates opportunities and priorities for power production, thus driving the development of innovative technologies. Key requirements for improving photovoltaics are outlined including cell efficiency, specific power, packaging, reliability, and affordability issues. The competition faced by photovoltaic cells is discussed with specific reference to solar dynamics and nuclear radioisotope thermal generator systems.
Sankar, Krishna Moorthi
Nanotechnology, even after 55 years since its foundation (1959 Richard Feynman's speech - `There is lot of space in the bottom'), is still in its infancy. However, of late, there has been a large increase in the research being done in this field in many prominent Universities and Research institutions across the globe. Nanorobotics is the combination of Nanotechnology and the science of Robotics, to create robots that are only a few nanometres (10-9 metres) in size. Nanobots are yet to be made. But with the current pace of ongoing researches, scientists predict that nanobots will be made a reality by next ten years. The main proposed function of nanobots is to use them in the medical field to interact with cells or intra-cellular substances and prevent or reverse structural and genetical problems and diseases. One of the major challenges faced while creating a nanobot to travel through human body is to power it. Nanobots would require a very small yet highly potential source of energy. There are many hypothesised energy sources for nanobots which are either already available within the human body naturally or which are to be supplied externally. But, all of these energy sources pose a few challenges which need to be addressed if they are to be used to power nanobots. These challenges can be overcome using a number of strategies that can be used to make an economically, ecologically and medically viable energy source.
Full Text Available Noor Alolabi,1 Haley Augustine,1 Achilles Thoma1–3 1Division of Plastic Surgery, Department of Surgery, 2Surgical Outcomes Research Centre, 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Abstract: Over the last two decades, 113 vascularized composite allotransplantation (VCA of the hand have been performed in 76 patients globally. The procedure that was once regarded as experimental has certainly emerged as a clinical reality with multiple centers worldwide now performing it. The psychological and physical impact of losing an upper extremity is profound. Amputees face significant challenges contributing to disability and dependence even with activities of daily living. Hand transplantation offers functions with restoring sensation, voluntary motor control, and proprioception, as well as a sense of feeling “whole” again. Along with these benefits, however, transplantation carries a significant risk profile attributed to the complications of life-long immunosuppression and possible rejection. Moreover, the procedure carries a significant financial burden to the health care system. As hand VCA is becoming more widely accepted and performed worldwide, there are still many challenges that will face its rapid growth. This review highlights some of the challenges facing hand VCA including patient selection, effect on quality of life, financial burden, functional outcomes, and complications of immunosuppression. Keywords: hand transplantation, vascularized composite allotransplantation
Formenti, Luca Riccardo; Nørregaard, Anders; Bolic, Andrijana;
Industrial fermentation processes are increasingly popular, and are considered an important technological asset for reducing our dependence on chemicals and products produced from fossil fuels. However, despite their increasing popularity, fermentation processes have not yet reached the same...... engineering challenges: scaling up and scaling down fermentation processes, the influence of morphology on broth rheology and mass transfer, and establishing novel sensors to measure and control insightful process parameters. The greatest emphasis is on the challenges posed by filamentous fungi, because...
Wei Wang; Ming Liu; Andrew Hsu
Nanotechnology may well prove to be the 21st century's new wave of scientific knowledge that transforms people's lives. Nanotechnology research activities are booming around the globe. This article reviews the recent progresses made on nanoelectronic research in US and China, and introduces several novel hybrid solutions specifically useful for future computer technology. These exciting new directions will lead to many future inventions, and have a huge impact to research communities and industries.
This book focuses on the challenges and changes that new technologies bring to human resources (HR) of modern organizations. It examines the technological implications of the last changes taking place and how they affect the management and motivation of human resources belonging to these organizations. It looks for ways to understand and perceive how organizational HR, individually and as a team, conceptualize, invent, adapt, define and use organizational technology, as well as how they are constrained by features of it. The book provides discussion and the exchange of information on principles, strategies, models, techniques, methodologies and applications of human resources management and technological challenges and changes in the field of industry, commerce and services.
Metagenomics is a relatively new but fast growing field within environmental biology directed at obtaining knowledge on genomes of environmental microbes as well as of entire microbial communities. With the sequencing technologies improving steadily, generating large amounts of sequence is becoming routine. However, it remains difficult to connect specific microbial phyla to specific functions in the environment. A number of 'functional metagenomics' approaches have been implemented in the recent years that allow high-resolution genomic analysis of uncultivated microbes, connecting them to specific functions in the environment. These include analysis of niche-specialized low complexity communities, reactor enrichments, and the use labeling technologies. Metatranscriptomics and metaproteomics are the newest sub-disciplines within the metagenomics field that provide further levels of resolution for functional analysis of uncultivated microbes and communities. The recent emergence of new (next generation) sequencing technologies, resulting in higher sequence output and dramatic drop in the price of sequencing, will be defining a new era in metagenomics. At this time the sequencing effort will be taken to a new level to allow addressing new, previously unattainable biological questions as well as accelerating genome-based discovery for medical and biotechnological applications.
This paper discusses the successful implementation of simple video technologies at the Savannah River Site (SRS) to perform complex visual inspection, monitoring, and surveillance tasks. Because SRS facilities are similar to those of an industrial plant, the environmental and accessibility considerations for remote viewing are the primary determining factors in the selection of technology. The constraints and challenges associated with remote viewing are discussed, and examples of applications are given.
Blaabjerg, Frede; Thoegersen, Paul
The main trends within Adjustable Drives in industrial and appliance applications for the next decade are discussed based on the newest developments seen on the market and a few historical trends. Different drive configurations are presented and the general demands to adjustable speed drives...... are specified. Further on power architectures and motor types are discussed in a short term and long-term view. Possible drivers of the future development are identified, and the concept of an ?Electronic Motor? is discussed. A number of applications are presented where variable speed is attractive....
Li, Meina; Zhang, Lulu
Regional haze which triggered both public anxiety and official concerns has been one of the most disastrous weather events in China in recent years. Haze not only had negative impact on daily life, but also an indicator of high concentrations of PM2.5 with the potential to adversely impact public health by damaging people's respiratory, cardiovascular, blood vessel of brain and nervous system. The dust-haze is an accumulated result for a long time of both natural factors and unhealthy economic growth model. In order to tackle air pollution, a number of policies and measures which target at reducing pollution emission and promoting alternative energy production had been implemented. Although significant improvement has occurred in China, change the development mode of "high growth, high pollution" and balance environmental conservation with the well-being of the population remains a challenge for China.
Biagini, M E
Operation of the B-Factories (PEP-II and KEKB) has been very successful, both having exceeded their design peak and integrated luminosity and provided a huge amount of good data to the experiments. Proposal for upgrades, in order to achieve about two order of magnitude larger luminosity, are in progress in Japan, with Super-KEKB, and in Europe, with SuperB. Very high beam intensity, very short bunch length and low Interaction Point beta-functions are the key points of the Japanese design, very challenging for the hardware components (RF, vacuum). On the other hand SuperB exploits a new collision scheme, namely large Piwinski angle and "crab waist", which will allow to reach a luminosity two order of magnitude larger without increasing beam currents and decreasing bunch lengths. In this talk the present status of the two projects will be reviewed.
Durand, H; Stern, G
The preservation of ultra-low emittances in the main linac and Beam Delivery System area is one of the main challenges for linear colliders. This requires alignment tolerances never achieved before at that scale, down to the micrometre level. As a matter of fact, in the LHC, the goal for the smoothing of the components was to obtain a 1σ deviation with respect to a smooth curve of 0.15 mm over a 150 m long sliding window, while for the CLIC project for example, it corresponds to 10 μm over a sliding window of 200 m in the Beam Delivery System area. Two complementary strategies are being studied to fulfil these requirements: the development and validation of long range alignment systems over a few hundreds of metres and short range alignment systems over a few metres. The studies undertaken, with associated tests setups and the latest results will be detailed, as well as their application for the alignment of both CLIC and ILC colliders.
apps designed to develop social and daily life skills in young people with autism spectrum disorders (ASD), should be developed and implemented in the future. We also set out a roadmap for a future research agenda, indicating further promising lines of enquiry that could potentially lead......We position the HANDS project in the wider context of developments in mobile technology and consider what legacy the project leaves. We identify a series of overall conclusions and recommendations from the project about the ways in which “HANDS-like” technology, i.e. integrated suites of mobile...... to the development of effective assistive mobile technology that has the potential to make a difference to the lives of young people with ASD and other people with social and cognitive impairments....
We position the HANDS project in the wider context of developments in mobile technology and consider what legacy the project leaves. We identify a series of overall conclusions and recommendations from the project about the ways in which “HANDS-like” technology, i.e. integrated suites of mobile...... apps designed to develop social and daily life skills in young people with autism spectrum disorders (ASD), should be developed and implemented in the future. We also set out a roadmap for a future research agenda, indicating further promising lines of enquiry that could potentially lead...... to the development of effective assistive mobile technology that has the potential to make a difference to the lives of young people with ASD and other people with social and cognitive impairments....
Dr. Anwar M. Mousa
Full Text Available This paper provides a survey for the main challenges of future research and development (R&D for next generation mobile networks (NGNs. It addresses software and hardware re-configurability with focus on reconfigurable coupling and interworking amongst heterogeneous wireless access networks. It also explores the promising technologies for NGNs such as nanotechnology, cloud computing and texting by thinking. The paper then highlights the challenging research areas for enhancing network performance and affordability beginning with All IP network and security issues, Vehicular Ad Hoc Networks (VANET and the necessity of high data rates at cell edges. Investigating the viability of cooperative networks and one unified global standard for NGNs, the paper analyzes macro-diversity and advanced multi-cell coordination for mitigating inter-cell interference. Direct device-to-device communication, global coverage using satellites and high-altitude platforms are presented as possible evolution paths for space roaming and extending NGN’ radio-access. Finally, the paper inspects the most developing applications for NGNs such as World-Wide Wireless Web (WWWW, machine-type communication, wireless sensor networks (WSNs, e-healthcare systems and wearable devices with AI capabilities.
Full Text Available Meeting the educational needs of students currently requires moving towardcollaborative electronic and mobile learning systems that parallel the vision ofWeb 2.0. However, factors such as data freedom, brokerage, interconnectivityand the Internet of Things add to a vision for Web 3.0 that will require con-sideration in the development of future campus-based, distance and vocationalstudy. So, education can, in future, be expected to require deeper technologicalconnections between students and learning environments, based on signiﬁcantuse of sensors, mobile devices, cloud computing and rich-media visualization.Therefore, we discuss challenges associated with such a futuristic campus con-text, including how learning materials and environments may be enriched byit. As an additional novel element the potential for much of that enrichmentto be realized through development by students, within the curriculum, is alsoconsidered. We will conclude that much of the technology required to embracethe vision of Web 3.0 in education already exists, but that further research inkey areas is required for the concept to achieve its full potential.
van de Vegte, John; Som de Cerff, Wim; Verhoef, Hans; Plieger, Maarten; de Vreede, Ernst; van der Neut, Ian; Bos, Jeroen; Ha, Siu-Siu; Sluiter, Raymond; Willem Noteboom, Jan; Klein Baltink, Henk; Reijmerink, Mieke
The Royal Netherlands Meteorological Institute (KNMI) has over 150 years of knowledge and gathered information related to weather, Climate and Seismology. A huge part of this information is from numerical models, insitu sensor networks and remote sensing satellites. This digital collection is becoming more and more available in the newly developed KNMI Data Centre, that is now 2 years operational. The KNMI Data Centre project has a user driven development approach where SCRUM is chosen to get maximum user involvement in a relative short timeframe. The system is build on open standards and proven opensource technology (which includes in-house developed software like ADAGUC WMS and Portal). The presentation will focus on the aspects of developing the initial KNMI Data Centre, the operational use of the last 2 years, and how a major release for the coming year will be realized. The new release which will focus on better user experience and extending the technical data interfaces to the data centre. Keywords: Agile, Usage Statistics, Open Data, Inspire, DOI, WMS, WCS, OPeNDAP
Guido, Marcello; Tumolo, Maria Rosaria; Verri, Tiziano; Romano, Alessandro; Serio, Francesca; De Giorgi, Mattia; De Donno, Antonella; Bagordo, Francesco; Zizza, Antonella
Human bocavirus (HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate (HBoV1), namely HBoV2, HBoV3 and HBoV4, have been detected principally in human faeces. HBoVs are small non-enveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1 (NS1) and nuclear phosphoprotein (NP1) and the third the viral capsid proteins 1 and 2 (VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBoV infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzyme-linked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoVs as true pathogen or innocent bystander is also emphasized.
Full Text Available Anagha Medsinge,1,2 Ken K Nischal1,2 1Pediatric Ophthalmology, Strabismus, and Adult Motility, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, (UPMC 2University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Abstract: Cataract is a significant cause of visual disability in the pediatric population worldwide and can significantly impact the neurobiological development of a child. Early diagnosis and prompt surgical intervention is critical to prevent irreversible amblyopia. Thorough ocular evaluation, including the onset, duration, and morphology of a cataract, is essential to determine the timing for surgical intervention. Detailed assessment of the general health of the child, preferably in conjunction with a pediatrician, is helpful to rule out any associated systemic condition. Although pediatric cataracts have a diverse etiology, with the majority being idiopathic, genetic counseling and molecular testing should be undertaken with the help of a genetic counselor and/or geneticist in cases of hereditary cataracts. Advancement in surgical techniques and methods of optical rehabilitation has substantially improved the functional and anatomic outcomes of pediatric cataract surgeries in recent years. However, the phenomenon of refractive growth and the process of emmetropization have continued to puzzle pediatric ophthalmologists and highlight the need for future prospective studies. Posterior capsule opacification and secondary glaucoma are still the major postoperative complications necessitating long-term surveillance in children undergoing cataract surgery early in life. Successful management of pediatric cataracts depends on individualized care and experienced teamwork. We reviewed the etiology, preoperative evaluation including biometry, choice of intraocular lens, surgical techniques, and recent developments in the field of childhood cataract. Keywords: children, pediatric cataract, infantile
Miller, S. A.; Heinze, T.; Hamidi, S.; Galvan, B.
and future plans, and show that a GPU-based modeling approach is fast, high-resolution, and can reproduce experimental results of fluid injection experiments with numerical resolution at the grain-scale of the experiment.
The presentation will focus on the importance of interdisciplinary research for addressing future aerospace challenges. Examples of current research activities at NASA's Glenn Research Center will be provided to illustrate the importance of interdisciplinary research. Challenges with conducting interdisciplinary research will be discussed.
Computing of the future will be affected by a number of fundamental technologies in development today, many of which are already on the way to becoming commercialized. In this series of lectures, we will discuss hardware and software development that will become mainstream in the timeframe of a few years and how they will shape or change the computing landscape - commercial and personal alike. Topics range from processor and memory aspects, programming models and the limits of artificial intelligence, up to end-user interaction with wearables or e-textiles. We discuss the impact of these technologies on the art of programming, the data centres of the future and daily life. On the third day of the Future Computing Technology series, we will touch on societal aspects of the future of computing. Our perception of computers may at time seem passive, but in reality we are a vital chain of the feedback loop. Human-computer interaction, innovative forms of computers, privacy, process automation, threats and medica...
Full Text Available During the past 20 years there has been a significant growth of the solar photovoltaic (PV technology and today is considered by many countries as an important technology for the future. Many countries have already established or are in the process of establishing support programs to encourage the adoption of this new technology following in this way the examples of the major players of the PV market. In this work, an investigation of the technology and market future prospects of PV systems is carried out. In particular the PV key benefits are presented and the various PV solar cell technologies are described and compared. Emphasis has been given to the current and future PV solar systems market demand including their current and future economics. Solar PV has two big challenges that need to be resolved. Production costs need to go down before it becomes economically sustainable, while production capacity must continue to grow in order for PV to become a significant player in the global energy market.
The promise of the future shines brightly for nuclear energy technology and production, yet also holds many challenges. Focus on new reactor designs is currently aiming at what is termed the fourth generation of reactors, which will come into operation after 2030. The 10 countries participating in the Generation-IV International Forum to develop the new generation of reactors have designated six reactor designs that will be studied. This paper will briefly discuss some of these challenges in new reactor designs in general. In addition to the challenges posed by new reactor designs, radiation protection is also faced with a series of challenges for the future. These are borne from experience with the implementation of the current system of radiological protection, from the evolution of radiation biological research, and from changes in society in the area of radiological risk assessment and management. This paper will address all of these emerging challenges, and point towards approaches to resolve them in the future.
as snapshots of an evolutionary process, but the conclusions drawn here are significant for future developments with mobile assistive technology for people with ASD, as well as for other conditions. The book will be of interest to professionals working with young people with ASD, human-computer interaction......International interest in the use of assistive and ambient information and communication technologies to support people with a range of cognitive impairments is growing rapidly. Autism spectrum disorders (ASDs), which affect social skills, communicative abilities and behavior, are of particular...... of various fields, the widely shared view is that innovative ICT may hold the key to more efficient support and intervention in the near future. This book summarizes the results and conclusions of HANDS, an international research and development project supported by the 7th Framework Programme...
Computing of the future will be affected by a number of fundamental technologies in development today, many of which are already on the way to becoming commercialized. In this series of lectures, we will discuss hardware and software development that will become mainstream in the timeframe of a few years and how they will shape or change the computing landscape - commercial and personal alike. Topics range from processor and memory aspects, programming models and the limits of artificial intelligence, up to end-user interaction with wearables or e-textiles. We discuss the impact of these technologies on the art of programming, the data centres of the future and daily life. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Go...
Choi, S. U.-S.
Downscaling or miniaturization has been a recent major trend in modern science and technology. Engineers now fabricate microscale devices such as microchannel heat exchangers, and micropumps that are the size of dust specks. Further major advances would be obtained if the coolant flowing in the microchannels were to contain nanoscale particles to enhance heat transfer. Nanofluid technology will thus be an emerging and exciting technology of the 21st century. This paper gives a brief history of the Advanced Fluids Program at Argonne National Laboratory (ANL), discusses the concept of nanofluids, and provides an overview of the R and D program at ANL on the production, property characterization, and performance of nanofluids. It also describes examples of potential applications and benefits of nanofluids. Finally, future research on the fundamentals and applications of nanofluids is addressed.
Recently the Information Technology is developing very rapidly and the total traffic on the Internet is increasing dramatically. The numerous equipments connected to the Internet must be operated at very high-speed and the electricity consumed in the Internet is also increasing. Superconductivity devices of very high-speed and very low power consumption must be introduced. These superconducting devices will play very important roles in the future information society. Coated conductors will be used to generate extremely high magnetic fields of beyond 20 T at low temperatures. At the liquid nitrogen temperature they can find many applications in a wide range of Power Technology and other industries, since we have already large critical current and brilliant magnetic field dependences in some prototypes of coated conductors. It is becoming certain that the market for the superconductivity technology will be opened between the years of 2005 and 2010.
Gilbert, Tricia; Jin, Jenny; Bergerm Jason; Henriksen, Steven
This National Aeronautics and Space Administration (NASA) Contractor Report summarizes and documents the work performed to investigate technologies that could support long-term aeronautical mobile communications operating concepts for air traffic management (ATM) in the timeframe of 2020 and beyond, and includes the associated findings and recommendations made by ITT Corporation and NASA Glenn Research Center to the Federal Aviation Administration (FAA). The work was completed as the final phase of a multiyear NASA contract in support of the Future Communication Study (FCS), a cooperative research and development program of the United States FAA, NASA, and EUROCONTROL. This final report focuses on an assessment of final five candidate technologies, and also provides an overview of the entire technology assessment process, including final recommendations.
Orecchioni, Marco; Cabizza, Roberto; Bianco, Alberto; Delogu, Lucia Gemma
Nowadays cancer remains one of the main causes of death in the world. Current diagnostic techniques need to be improved to provide earlier diagnosis and treatment. Traditional therapy approaches to cancer are limited by lack of specificity and systemic toxicity. In this scenario nanomaterials could be good allies to give more specific cancer treatment effectively reducing undesired side effects and giving at the same time accurate diagnosis and successful therapy. In this context, thanks to its unique physical and chemical properties, graphene, graphene oxide (GO) and reduced graphene (rGO) have recently attracted tremendous interest in biomedicine including cancer therapy. Herein we analyzed all studies presented in literature related to cancer fight using graphene and graphene-based conjugates. In this context, we aimed at the full picture of the state of the art providing new inputs for future strategies in the cancer theranostic by using of graphene. We found an impressive increasing interest in the material for cancer therapy and/or diagnosis. The majority of the works (73%) have been carried out on drug and gene delivery applications, following by photothermal therapy (32%), imaging (31%) and photodynamic therapy (10%). A 27% of the studies focused on theranostic applications. Part of the works here discussed contribute to the growth of the theranostic field covering the use of imaging (i.e. ultrasonography, positron electron tomography, and fluorescent imaging) combined to one or more therapeutic modalities. We found that the use of graphene in cancer theranostics is still in an early but rapidly growing stage of investigation. Any technology based on nanomaterials can significantly enhance their possibility to became the real revolution in medicine if combines diagnosis and therapy at the same time. We performed a comprehensive summary of the latest progress of graphene cancer fight and highlighted the future challenges and the innovative possible
Shaner, Dale L; Beckie, Hugh J
This review is both a retrospective (what have we missed?) and prospective (where are we going?) examination of weed control and technology, particularly as it applies to herbicide-resistant weed management (RWM). Major obstacles to RWM are discussed, including lack of diversity in weed management, unwillingness of many weed researchers to conduct real integrated weed management research or growers to accept recommendations, influence or role of agrichemical marketing and governmental policy and lack of multidisciplinary research. We then look ahead to new technologies that are needed for future weed control in general and RWM in particular, in areas such as non-chemical and chemical weed management, novel herbicides, site-specific weed management, drones for monitoring large areas, wider application of 'omics' and simulation model development. Finally, we discuss implementation strategies for integrated weed management to achieve RWM, development of RWM for developing countries, a new classification of herbicides based on mode of metabolism to facilitate greater stewardship and greater global exchange of information to focus efforts on areas that maximize progress in weed control and RWM. There is little doubt that new or emerging technologies will provide novel tools for RMW in the future, but will they arrive in time? © 2013 Her Majesty the Queen in Right of Canada Pest Management Science © 2013 Society of Chemical Industry.
eliminating the source of pollution, but also on blocking the pathways from contaminants to receptors or reducing the exposure to contaminants,. Future challenge integration of sustainability into remediation decision-making. Soil is not a waste! There is a growing interest in the clean up approaches that maintain soil quality after remediation treatments. This issue is of great importance in the U.S.A. where the EPA from 2009 is promoting innovative clean-up strategies (Green Remediation). Green remediation is defined as the practice of considering all environmental effects of remedy and incorporating options to maximize environmental benefit of cleanup actions . These remediation strategies restore contaminated sites to productive use with a great attention to the global environmental quality, including the preservation of soil functionality according to the following principles: use minimally invasive technologies; use passive energy technologies such as bioremediation and phytoremediation as primary remedies or finishing steps where possible and effective; minimize soil and habitat disturbance; minimize bioavailability of contaminants trough adequate contaminant source and plume control If we move from the current definition of remedial targets based on total concentrations, technologies with low impact on the environment can be utilized reducing the wrong choice to disposal soil in landfill destroying quickly a not renewable essential resource.
Mukhopadhyay, Subhas; Jayasundera, Krishanthi; Bhattacharyya, Nabarun
This book is written for academic and industry professionals working in the field of sensing, instrumentation and related fields, and is positioned to give a snapshot of the current state of the art in sensing technology, particularly from the applied perspective. The book is intended to give a broad overview of the latest developments, in addition to discussing the process through which researchers go through in order to develop sensors, or related systems, which will become more widespread in the future.
Dr. W. Krimmel
Full Text Available The journey to the past of torque measurement technology begins in the 17th century. It takes us from the first incipiencies of torque measurement to the problem of the transfer of the measurement signal from a rotating shaft, which existed for several decades. This task was solved by the integration of high-precise digital measuring amplifiers in the torque sensors, which is expressed by broad application fields, today. The future will appertain to highly dynamic measuring sensors as well as to intelligent torque sensors, which are able to transmit their sensor-specific characteristics to evaluation devices.
Geisse, Sabine; Voedisch, Bernd
The first protocols describing transient gene expression in mammalian cells for the rapid generation of recombinant proteins emerged more than 10 years ago as an alternative to the establishment of stable, often amplified clonal cell lines, and relieved somewhat the bias against mammalian cell systems as being too complicated, labor intensive, and tedious to serve as a source for tool proteins in industrial research and academia. Over the past decade, these attempts have been refined and optimized, giving rise to expression protocols applicable in every lab in dependence on available tools, equipment, and envisaged outcome. This chapter summarizes the development of transient expression technologies over the past decade up to its current status and provides an outlook into what may be the future of transient technology development.
Hamelinck, Roger; Rosielle, Nick; Steinbuch, Maarten; Doelman, Niek
New deformable mirror technology is developed by the Technische Universiteit Eindhoven, Delft University of Technology and TNO Science and Industry. Several prototype adaptive deformable mirrors are realized mirrors, up to 427 actuators and ∅150mm diameter, with characteristics suitable for future AO systems. The prototypes consist of a 100µm thick, continuous facesheet on which low voltage, electromagnetic, push-pull actuators impose out-of-plane displacements. The variable reluctance actuators with ±10µm stroke and nanometer resolution are located in a standard actuator module. Each module with 61 actuators connects to a single PCB with dedicated, 16 bit, PWM based, drivers. A LVDS multi-drop cable connects up to 32 actuator modules. With the actuator module, accompanying PCB and multi-drop system the deformable mirror technology is made modular in its mechanics and electronics. An Ethernet-LVDS bridge enables any commercial PC to control the mirror using the UDP standard. Latest results of the deformable mirror technology development are presented.
The paper develops four alternative core-technology advancement specifications, one for each of the four strategic goal options for government investment in human space flight. Already discussed in the literature, these are: Explore Mars; Settle the Moon; accelerate commercial development of Space Passenger Travel; and enable industrial scale-up of Space Solar Power for Earth. In the case of the Explore Mars goal, the paper starts with the contemporary NASA accounting of ?55 Mars-enabling technologies. The analysis decomposes that technology agenda into technologies applicable only to the Explore Mars goal, versus those applicable more broadly to the other three options. Salient technology needs of all four options are then elaborated to a comparable level of detail. The comparison differentiates how technologies or major developments that may seem the same at the level of budget lines or headlines (e.g., heavy-lift Earth launch) would in fact diverge widely if developed in the service of one or another of the HSF goals. The paper concludes that the explicit choice of human space flight goal matters greatly; an expensive portfolio of challenging technologies would not only enable a particular option, it would foreclose the others. Technologies essential to enable human exploration of Mars cannot prepare interchangeably for alternative futures; they would not allow us to choose later to Settle the Moon, unleash robust growth of Space Passenger Travel industries, or help the transition to a post-petroleum future with Space Solar Power for Earth. The paper concludes that a decades-long decision in the U.S.--whether made consciously or by default--to focus technology investment toward achieving human exploration of Mars someday would effectively preclude the alternative goals in our lifetime.
Chern, E. James
The initiative to explore space and extend a human presence across our solar system to revisit the moon and Mars post enormous technological challenges to the nation's space agency and aerospace industry. Key areas of technology development needs to enable the endeavor include advanced materials, structures and mechanisms; micro/nano sensors and detectors; power generation, storage and management; advanced thermal and cryogenic control; guidance, navigation and control; command and data handling; advanced propulsion; advanced communication; on-board processing; advanced information technology systems; modular and reconfigurable systems; precision formation flying; solar sails; distributed observing systems; space robotics; and etc. Quality assurance concerns such as functional performance, structural integrity, radiation tolerance, health monitoring, diagnosis, maintenance, calibration, and initialization can affect the performance of systems and subsystems. It is thus imperative to employ innovative nondestructive evaluation methodologies to ensure quality and integrity of advanced space systems. Advancements in integrated multi-functional sensor systems, autonomous inspection approaches, distributed embedded sensors, roaming inspectors, and shape adaptive sensors are sought. Concepts in computational models for signal processing and data interpretation to establish quantitative characterization and event determination are also of interest. Prospective evaluation technologies include ultrasonics, laser ultrasonics, optics and fiber optics, shearography, video optics and metrology, thermography, electromagnetics, acoustic emission, x-ray, data management, biomimetics, and nano-scale sensing approaches for structural health monitoring.
The phrase Internet of Things (IoT) heralds a vision of the future Internet where connecting physical things, from banknotes to bicycles, through a network will let them take an active part in the Internet, exchanging information about themselves and their surroundings. This will give immediate access to information about the physical world and the objects in it leading to innovative services and increase in efficiency and productivity. This paper studies the state-of-the-art of IoT and presents the key technological drivers,potential applications, challenges and future research areas in the domain of IoT. IoT definitions from different perspective in academic and industry communities are also discussed and compared. Finally some major issues of future research in IoT are identified and discussed briefly.
Oberhänsli, Roland; Lambert, Ian
In a world with rapidly increasing population and technological development new space based remote sensing tools allowed for new discoveries and production of water, energy- and mineral-resources, including minerals, soils and construction materials. This has impact on politics, socio-economic development and thus calls for a strong involvement of geosciences because one of humanities biggest challenges will be, to rise living standards particularly in less developed countries. Any growth will lead to an increase of demand for natural resources. But especially for readily available mineral resources supply appears to be limited. Particularly demand for so called high-tech commodities - platinum group or rare earth elements - increased. This happened often faster than new discoveries were made. All this, while areas available for exploration decreased as the need for urban and agricultural use increased. Despite strong efforts in increasing efficiency of recycling, shortage in some commodities has to be expected. A major concern is that resources are not distributed evenly on our planet. Thus supplies depend on political stability, socio-economic standards and pricing. In the light of these statements IUGS is scoping a new initiative, Resourcing Future Generations (RFG), which is predicated on the fact that mining will continue to be an essential activity to meet the needs of future generations. RFG is aimed at identifying and addressing key challenges involved in securing natural resources to meet global needs post-2030. We consider that mineral resources should be the initial focus, but energy, soils, water resources and land use should also be covered. Addressing the multi-generational needs for mineral and other natural resources requires data, research and actions under four general themes: 1. Comprehensive evaluation and quantification of 21st century supply and demand. 2. Enhanced understanding of subsurface as it relates to mineral (energy and groundwater
Remembering our past is an essential first step into the future. Building upon that philosophy, our objective is to summarize two presentations from a 2012 Soil Science Society of America (SSSA) symposium focused on soil management challenges in response to climate change in order to examine: (1) ho...
... ADMINISTRATION Future Systems Technology Advisory Panel Meeting AGENCY: Social Security Administration (SSA... Hotel Washington, DC, Diplomat Room. ADDRESSES: 2500 Calvert Street, NW., Washington, DC 20008... Security independent advice and recommendations on the future of systems technology and electronic services...
Pilat, Joseph R [Los Alamos National Laboratory
There is growing interest in, and hopes for, nuclear disarmament in governments and nongovernmental organizations (NGOs) around the world. If a nuclear-weapon-free world is to be achievable, verification and compliance will be critical. VerifYing disarmament would have unprecedented scientific, technological and political challenges. Verification would have to address warheads, components, materials, testing, facilities, delivery capabilities, virtual capabilities from existing or shutdown nuclear weapon and existing nuclear energy programs and material and weapon production and related capabilities. Moreover, it would likely have far more stringent requirements. The verification of dismantlement or elimination of nuclear warheads and components is widely recognized as the most pressing problem. There has been considerable research and development done in the United States and elsewhere on warhead and dismantlement transparency and verification since the early 1990s. However, we do not today know how to verifY low numbers or zero. We need to develop the needed verification tools and systems approaches that would allow us to meet this complex set of challenges. There is a real opportunity to explore verification options and, given any realistic time frame for disarmament, there is considerable scope to invest resources at the national and international levels to undertake research, development and demonstrations in an effort to address the anticipated and perhaps unanticipated verification challenges of disarmament now andfor the next decades. Cooperative approaches have the greatest possibility for success.
Positron emission tomography (PET) plays important roles in cancer diagnosis, neuroimaging and molecular imaging research; but potential points remain for which big improvements could be made, including spatial resolution, sensitivity and manufacturing costs. Higher spatial resolution is essential to enable earlier diagnosis, and improved sensitivity results in reduced radiation exposure and shortened measurement time. Therefore, research on next generation PET technologies remains a hot topic worldwide. In this paper, innovation and future technologies for the next generation PET scanners, such as time-of-flight measurement and simultaneous PET/MRI measurement, are described. Among them, depth-of-interaction (DOI) measurement in the radiation sensor will be a key technology to get any significant improvement in sensitivity while maintaining high spatial resolution. DOI measurement also has a potential to expand PET application fields because it allows for more flexible detector arrangement. As an example, the world's first, open-type PET geometry "OpenPET", which is expected to lead to PET imaging during treatment, is under development. The DOI detector itself continues to evolve with the help of recently developed semiconductor photodetectors, often referred to as silicon photomultipliers.
We describe and evaluate the technical, political, and economic challenges involved with widespread adoption of renewable energy technologies. First, we estimate fossil fuel resources and reserves and, together with the current and projected global primary power production rates, estimate the remaining years of oil, gas, and coal. We then compare the conventional price of fossil energy with that from renewable energy technologies (wind, solar thermal, solar electric, biomass, hydroelectric, and geothermal) to evaluate the potential for a transition to renewable energy in the next 20-50 years. Secondly, we evaluate - per the Intergovernmental Panel on Climate Change - the greenhouse constraint on carbon-based power consumption as an unpriced externality to fossil-fuel use, considering global population growth, increased global gross domestic product, and increased energy efficiency per unit GDP. This constraint is projected to drive the demand for carbon-free power well beyond that produced by conventional supply/demand pricing tradeoffs, to levels far greater than current renewable energy demand. Thirdly, we evaluate the level and timescale of R&D investment needed to produce the required quantity of carbon-free power by the 2050 timeframe. Fourth, we evaluate the energy potential of various renewable energy resources to ascertain which resources are adequately available globally to support the projected demand. Fifth, we evaluate the challenges to the chemical sciences to enable the cost-effective production of carbon-free power required. Finally, we discuss the effects of a change in primary power technology on the energy supply infrastructure and discuss the impact of such a change on the modes of energy consumption by the energy consumer and additional demands on the chemical sciences to support such a transition in energy supply.
Parandian, Alireza; Rip, Arie
Emerging technologies pose challenges for futures research because of their uncertainties combined with promises. Actors are anticipating and acting strategically. Sociotechnical scenarios building on endogenous futures support and enlighten actors. Such scenarios contribute to “strategic intelligence” about the technologies and their embedding in society. Organic and large area electronics promise to substitute silicon-based technologies, but firms and potential users are reluctant to invest...
Groff, Jennifer; Mouza, Chrystalla
Creating effective learning environments with technology remains a challenge for teachers. Despite the tremendous push for educators to integrate technology into their classrooms, many have yet to do so and struggle to find consistent success with technology-based instruction. The challenges to effective technology integration have been…
Tsiftsoglou, Asterios S; Ruiz, Sol; Schneider, Christian K
Biologic medicinal products developed via rDNA technology as recombinant protein-based medicines that have been in clinical use since the early 1980s as original biopharmaceuticals have greatly contributed to the therapy of severe metabolic and degenerative diseases. The recent expiration of the data protection or patents for most of them created opportunities for the development of copy versions of original biopharmaceuticals with similar biologic activity (termed biosimilars). Production of these new products is expected to meet worldwide demand, promote market competition, maintain the incentives for innovation, and sustain the healthcare systems. The licencing of these products, however, relies on the experience gained with the original biopharmaceuticals. Critical issues related to this class of medicinal products include their terminology (to avoid confusion with generics and non-innovator copy versions that have not been tested according to the biosimilar guidelines), manufacturing, and regulation. The European Union (EU) has been the first to establish a regulatory framework for marketing authorization application (MAA) and has named these products biosimilars, a term also recently adopted by the US FDA. Unlike the conventional, more common small molecular weight human medicines and chemical generics, protein-based medicines exhibit higher molecular weight, complexity in structure and function that can be affected by changes in the manufacturing process. Therefore, biosimilars represent a relatively heterogeneous class of medicinal products that make their regulation quite challenging. According to the current understanding in the EU, a biosimilar is a copy version of an already authorized biopharmaceutical (or reference product) with similar biologic activity, physicochemical characteristics, efficacy, and safety, based on a full comparability exercise at quality, preclinical and clinical level to ensure similar efficacy and safety. Guidance has been
It has been thirty years since the first active matrix (AM) flat panel display (FPD) was industrialized for portable televisions (TVs) in 1984. The AM FPD has become a dominant electronic display technology widely used from mobile displays to large TVs. The development of AM FPDs for mobile displays has significantly changed our lives by enabling new applications, such as notebook personal computers (PCs), smartphones and tablet PCs. In the future, the role of mobile displays will become even more important, since mobile displays are the live interface for the world of mobile communications in the era of ubiquitous networks. Various developments are being conducted to improve visual performance, reduce power consumption and add new functionality. At the same time, innovative display concepts and novel manufacturing technologies are being investigated to create new values.
... Health Intervention Technology? Join a Study Learn More Technology and the Future of Mental Health Treatment Introduction ... What is NIMH’s Role in Mental Health Intervention Technology? Between FY2009 and FY2015, NIMH awarded 404 grants ...
Kim, Jung; Sahama, Tony; Yang, Chung-Huang; 2013 International Conference on Future Information & Communication Engineering (ICFICE 2013)
These proceedings are based on the 2013 International Conference on Future Information & Communication Engineering (ICFICE 2013), which will be held at Shenyang in China from June 24-26, 2013. The conference is open to all over the world, and participation from Asia-Pacific region is particularly encouraged. The focus of this conference is on all technical aspects of electronics, information, and communications ICFICE-13 will provide an opportunity for academic and industry professionals to discuss the latest issues and progress in the area of FICE. In addition, the conference will publish high quality papers which are closely related to the various theories and practical applications in FICE. Furthermore, we expect that the conference and its publications will be a trigger for further related research and technology improvements in this important subject. "This work was supported by the NIPA (National IT Industry Promotion Agency) of Korea Grant funded by the Korean Government (Ministry of Science, ICT...
of the European Commission. The aim of the HANDS project was to develop and test a smartphone-based cognitive support system for intellectually able young people with ASDs, with a focus on use in secondary school environments. The results presented here include the HANDS system: a partly mobile, partly web...... Design and its philosophical foundations; a mapping of key ethical issues related to developing and applying mobile ICT for individuals with autism and other cognitive impairments. The experiences of teachers who implemented the system in school environments are also summarized. These results can be seen...... as snapshots of an evolutionary process, but the conclusions drawn here are significant for future developments with mobile assistive technology for people with ASD, as well as for other conditions. The book will be of interest to professionals working with young people with ASD, human-computer interaction...
Bulgiba, A M
In 1998, Malaysia opened its first hospital based on the "paperless and filmless" concept. Two are now in operation, with more to follow. Telemedicine is now being used in some hospitals and is slated to be the technology to watch. Future use of technology in health care will centre on the use of centralised patient databases and more effective use of artificial intelligence. Stumbling blocks include the enormous capital costs involved and difficulty in getting sufficient bandwidth to support applications on a national scale. Problems with the use of information technology in developing countries still remain; mainly inadequate skilled resources to operate and maintain the technology, lack of home-grown technology, insufficient experience in the use of information technology in health care and the attitudes of some health staff. The challenge for those involved in this field will not be in building new "paperless and filmless" institutions but in transforming current "paper and film-based" institutions to "paperless and filmless" ones and changing the mindset of health staff. Universities and medical schools must be prepared to respond to this new wave by incorporating elements of medical/health informatics in their curriculum and assisting governments in the planning and implementation of these projects. The experience of the UMMC is highlighted as an example of the difficulty of transforming a paper-based hospital to a "paperless and filmless" hospital.
Full Text Available Abstract For over a century, technologists and scientists have actively sought the development of exoskeletons and orthoses designed to augment human economy, strength, and endurance. While there are still many challenges associated with exoskeletal and orthotic design that have yet to be perfected, the advances in the field have been truly impressive. In this commentary, I first classify exoskeletons and orthoses into devices that act in series and in parallel to a human limb, providing a few examples within each category. This classification is then followed by a discussion of major design challenges and future research directions critical to the field of exoskeletons and orthoses.
For over a century, technologists and scientists have actively sought the development of exoskeletons and orthoses designed to augment human economy, strength, and endurance. While there are still many challenges associated with exoskeletal and orthotic design that have yet to be perfected, the advances in the field have been truly impressive. In this commentary, I first classify exoskeletons and orthoses into devices that act in series and in parallel to a human limb, providing a few examples within each category. This classification is then followed by a discussion of major design challenges and future research directions critical to the field of exoskeletons and orthoses. PMID:19538735
Lopez, Jose; Becker, Kurt; Thomsen, Hauke
This book provides the reader with an introduction to the physics of complex plasmas, a discussion of the specific scientific and technical challenges they present, and an overview of their potential technological applications. Complex plasmas differ from conventional high-temperature plasmas in several ways: they may contain additional species, including nanometer- to micrometer-sized particles, negative ions, molecules and radicals, and they may exhibit strong correlations or quantum effects. This book introduces the classical and quantum mechanical approaches used to describe and simulate complex plasmas. It also covers some key experimental techniques used in the analysis of these plasmas, including calorimetric probe methods, IR absorption techniques and X-ray absorption spectroscopy. The final part of the book reviews the emerging applications of microcavity and microchannel plasmas, the synthesis and assembly of nanomaterials through plasma electrochemistry, the large-scale generation of ozone using mi...
2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 31 May, 1, 2, 3, June from 11:00 to 12:00 on 31 May and 2, 3, June. From 10:00 to 12:00 on 1 June - Main Auditorium, bldg. 500 The ITER project: technological challenges J. LISTER / CRPP-EPFL, Lausanne, CH and P. BRUZZONE / CRPP-EPFL, Zürich, CH The first lecture reminds us of the ITER challenges, presents hard engineering problems, typically due to mechanical forces and thermal loads and identifies where the physics uncertainties play a significant role in the engineering requirements. The second lecture presents soft engineering problems of measuring the plasma parameters, feedback control of the plasma and handling the physics data flow and slow controls data flow from a large experiment like ITER. The last three lectures focus on superconductors for fusion. The third lecture reviews the design criteria and manufacturing methods for 6 milestone-conductors of large fusion devices (T-7, T-15, Tore Supra, LHD, W-7X, ITER). The evolution of the...
2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 31 May, 1, 2, 3, June from 11:00 to 12:00 on 31 May and 2, 3, June. From 10:00 to 12:00 on 1 June - Main Auditorium, bldg. 500 The ITER project: technological challenges J. LISTER / CRPP-EPFL, Lausanne and P. BRUZZONE / CRPP-EPFL, Zürich The first lecture reminds us of the ITER challenges, presents hard engineering problems, typically due to mechanical forces and thermal loads and identifies where the physics uncertainties play a significant role in the engineering requirements. The second lecture presents soft engineering problems of measuring the plasma parameters, feedback control of the plasma and handling the physics data flow and slow controls data flow from a large experiment like ITER. The last three lectures focus on superconductors for fusion. The third lecture reviews the design criteria and manufacturing methods for 6 milestone-conductors of large fusion devices (T-7, T-15, Tore Supra, LHD, W-7X, ITER). The evolution of the de...
Formenti, Luca Riccardo; Nørregaard, Anders; Bolic, Andrijana; Hernandez, Daniela Quintanilla; Hagemann, Timo; Heins, Anna-Lena; Larsson, Hilde; Mears, Lisa; Mauricio-Iglesias, Miguel; Krühne, Ulrich; Gernaey, Krist V
Industrial fermentation processes are increasingly popular, and are considered an important technological asset for reducing our dependence on chemicals and products produced from fossil fuels. However, despite their increasing popularity, fermentation processes have not yet reached the same maturity as traditional chemical processes, particularly when it comes to using engineering tools such as mathematical models and optimization techniques. This perspective starts with a brief overview of these engineering tools. However, the main focus is on a description of some of the most important engineering challenges: scaling up and scaling down fermentation processes, the influence of morphology on broth rheology and mass transfer, and establishing novel sensors to measure and control insightful process parameters. The greatest emphasis is on the challenges posed by filamentous fungi, because of their wide applications as cell factories and therefore their relevance in a White Biotechnology context. Computational fluid dynamics (CFD) is introduced as a promising tool that can be used to support the scaling up and scaling down of bioreactors, and for studying mixing and the potential occurrence of gradients in a tank.
Fares, Youssef; Fares, Jawad
Lebanon stands out as the one of the first countries in the Middle East and the Arab world to practice the medical specialty of neurosurgery. In addition, Lebanon has one of the best reputations for neurosurgery in this region. This article documents the history and current status of Lebanese neurosurgery. Residency and fellowship trainings are also highlighted, and political, socioeconomic, and academic challenges for the future of the profession are presented. Copyright © 2016 Elsevier Inc. All rights reserved.
Full Text Available Sleep medicine is a relatively new specialty in the medical community. The practice of sleep medicine in Saudi Arabia (KSA began in the mid to late nineties. Since its inception, the specialty has grown, and the number of specialists has increased. Nevertheless, sleep medicine is still underdeveloped in the KSA, particularly in the areas of clinical service, education, training and research. Based on available data, it appears that sleep disorders are prevalent among Saudis, and the demand for sleep medicine service is expected to rise significantly in the near future. A number of obstacles have been defined that hinder the progress of the specialty, including a lack of trained technicians, specialists and funding. Awareness about sleep disorders and their serious consequences is low among health care workers, health care authorities, insurance companies and the general public. A major challenge for the future is penetrating the educational system at all levels to demonstrate the high prevalence and serious consequences of sleep disorders. To attain adequate numbers of staff and facilities, the education and training of health care professionals at the level of sleep medicine specialists and sleep technologists is another important challenge that faces the specialty. This review discusses the current position of sleep medicine as a specialty in the KSA and the expected challenges of the future. In addition, it will guide clinicians interested in setting up new sleep medicine services in the KSA or other developing countries through the potential obstacles that may face them in this endeavor.
Bahammam, Ahmed S
Sleep medicine is a relatively new specialty in the medical community. The practice of sleep medicine in Saudi Arabia (KSA) began in the mid to late nineties. Since its inception, the specialty has grown, and the number of specialists has increased. Nevertheless, sleep medicine is still underdeveloped in the KSA, particularly in the areas of clinical service, education, training and research. Based on available data, it appears that sleep disorders are prevalent among Saudis, and the demand for sleep medicine service is expected to rise significantly in the near future. A number of obstacles have been defined that hinder the progress of the specialty, including a lack of trained technicians, specialists and funding. Awareness about sleep disorders and their serious consequences is low among health care workers, health care authorities, insurance companies and the general public. A major challenge for the future is penetrating the educational system at all levels to demonstrate the high prevalence and serious consequences of sleep disorders. To attain adequate numbers of staff and facilities, the education and training of health care professionals at the level of sleep medicine specialists and sleep technologists is another important challenge that faces the specialty. This review discusses the current position of sleep medicine as a specialty in the KSA and the expected challenges of the future. In addition, it will guide clinicians interested in setting up new sleep medicine services in the KSA or other developing countries through the potential obstacles that may face them in this endeavor.
Evans, Lyndon R
The Large Hadron Collider (LHC) incorporates many technological innovations in order to achieve its design objectives at the lowest cost. The two-in-one magnet design, with the two magnetic channels i ntegrated into a common yoke, has proved to be an economical alternative to two separate rings and allows enough free space in the existing (LEP) tunnel for a possible future re-installation of a lept on ring for e-p physics. In order to achieve the design energy of 7 TeV per beam, with a dipole field of 8.3 T, the superconducting magnet system must operate in superfluid helium at 1.9 K. The LHC wi ll be the first hadron machine to produce appreciable synchrotron radiation which, together with the heat load due to image currents, has to be absorbed at cryogenic temperatures. A brief review of th e machine design is given and some of the main technological and accelerator physics issues are discussed.
Shell's relationship with Norway goes back a long way and is very important to our future as well, as is evident from this presentation, which describes some of the pressures on a global energy business like Shell. It also deals with the fundamental importance of technology in the way we respond to those pressures. The power of innovation, and of partnerships, in keeping us at the front of the wave and, using our experiences, it is described how we at Shell deal with these issues. It also gives some examples of the benefits that have come out of our partnerships here in Norway, and the challenges and opportunities confronting those partnerships in the future.
Timmins, Nicholas E; Nielsen, Lars K
Blood transfusion depends on availability of donor material, and concerns over supply and safety have spurred development of methods to manufacture blood from stem cells. Current methods could theoretically yield therapeutic doses of red blood cells (RBCs) and platelets. However, due to the very large number of cells required to have any impact on supply (currently 10(19) RBC/year in the US), realization of routine manufacture faces significant challenges. Current yields are orders of magnitude too low for production of meaningful quantities, and the physical scale of the problem is a challenge in itself. We discuss these challenges in relation to current methods and how it might be possible to realize limited 'blood pharming' of neutrophils in the near future.
electronic shopping from home, and ill the creation of "e~ectronic malls where customers shop by computer at these electronic kiosks , are waiting in...lifestyle. (47:38) There will be a wider variety of health foods available in the future, many of which will be developed using future technology.(79:cptr 10...work to an older age," and will stay ii the workforce longer than in the past. (179:1CS; 117:89) In fact, the food industry today is tapping older
This publication relates to environmental challenges of the energy sector and options for future action. Following themes are discussed: Globalisation of the energy sector; environmental challenges; the challenge of climate change; options for future action
Al-Delaimy, Wael K
Neuroscience is advancing at a rapid pace, with new technologies and approaches that are creating ethical challenges not easily addressed by current ethical frameworks and guidelines. One fascinating technology is neuroimaging, especially functional Magnetic Resonance Imaging (fMRI). Although still in its infancy, fMRI is breaking new ground in neuroscience, potentially offering increased understanding of brain function. Different populations and faith traditions will likely have different reactions to these new technologies and the ethical challenges they bring with them. Muslims are approximately one-fifth of world population and they have a specific and highly regulated ethical and moral code, which helps them deal with scientific advances and decision making processes in an Islamically ethical manner. From this ethical perspective, in light of the relevant tenets of Islam, neuroimaging poses various challenges. The privacy of spirituality and the thought process, the requirement to put community interest before individual interest, and emphasis on conscious confession in legal situations are Islamic concepts that can pose a challenge for the use of something intrusive such as an fMRI. Muslim moral concepts such as There shall be no harm inflicted or reciprocated in Islam and Necessities overrule prohibitions are some of the criteria that might appropriately be used to guide advancing neuroscience. Neuroscientists should be particularly prudent and well prepared in implementing neuroscience advances that are breaking new scientific and ethical ground. Neuroscientists should also be prepared to assist in setting the ethical frameworks in place in advance of what might be perceived as runaway applications of technology.
Del Rosario, Ruben; Koudelka, John M.; Wahls, Rich; Madavan, Nateri
Commercial aviation relies almost entirely on subsonic fixed wing aircraft to constantly move people and goods from one place to another across the globe. While air travel is an effective means of transportation providing an unmatched combination of speed and range, future subsonic aircraft must improve substantially to meet efficiency and environmental targets.The NASA Fundamental Aeronautics Fixed Wing (FW) Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advanced technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. Multidisciplinary advances are required in aerodynamic efficiency to reduce drag, structural efficiency to reduce aircraft empty weight, and propulsive and thermal efficiency to reduce thrust-specific energy consumption (TSEC) for overall system benefit. Additionally, advances are required to reduce perceived noise without adversely affecting drag, weight, or TSEC, and to reduce harmful emissions without adversely affecting energy efficiency or noise.The paper will highlight the Fixed Wing project vision of revolutionary systems and technologies needed to achieve these challenging goals. Specifically, the primary focus of the FW Project is on the N+3 generation; that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe
- The aggressive research activities and generous studies focusing on the ubiquitous mobile computing carried-out during the last two decades have gained very tremendous outcomes to apply in broad areas of modern society lives. In the near future, the computing technology application is highly possible to emerge as the dominant method to connect any objects to the global ICT infrastructure, the internet. This talk mainly discusses several R&D achievements performed during the last five yea...
Alonso, Elisa; Field, Frank R; Kirchain, Randolph E
Platinum is an excellent catalyst, can be used at high temperatures, and is stable in many aggressive chemical environments. Consequently, platinum is used in many current industrial applications, notably automotive catalytic converters, and prospective vehicle fuel cells are expected to rely upon it. Between 2005 and 2010, the automotive industry used approximately 40% of mined platinum. Future automotive industry growth and automotive sales shifts toward new technologies could significantly alter platinum demand. The potential risks for decreased platinum availability are evaluated, using an analysis of platinum market characteristics that describes platinum's geophysical constraints, institutional efficiency, and dynamic responsiveness. Results show that platinum demand for an automotive fleet that meets 450 ppm greenhouse gas stabilization goals would require within 10% of historical growth rates of platinum supply before 2025. However, such a fleet, due largely to sales growth in fuel cell vehicles, will more strongly constrain platinum supply in the 2050 time period. While current platinum reserves are sufficient to satisfy this increased demand, decreasing platinum ore grade and continued concentration of platinum supply in a single geographic area are availability risk factors to platinum end-users.
This publication is part of our five-strand research project "Flexible Pedagogies: preparing for the future". It focuses on a better understanding of technology-enhanced learning (TEL) and: (1) identifies key international drivers in the move towards technology-enhanced learning; (2) highlights some of the challenges and opportunities…
Full Text Available Abstract Background The role of the pediatrician as genetic counselor is ideal because pediatricians have medical knowledge and experience with genetic disorders (e.g. Down syndrome. Moreover, pediatricians can provide comprehensive care in a medical home to patients with genetic disorders. However, changes in the curriculum of the pediatric resident are necessary to address the future challenges of effectively communicating genetic information to patients. The objective of this study was to explore these challenges and make recommendations for training to adequately prepare pediatricians for their future role as genetic counselors. Methods Three reviewers independently searched PubMed, OVID, and Medline databases to identify articles describing the challenges of communicating genetic information to patients, published from 1960 to December 2005. After the publications were identified and reviewed, four major areas of interest were identified in order to categorize the findings. Results Twenty-five publications were identified during the literature search. From the review, the following categories were selected to organize the findings: (1 Inherent difficulties of communicating and comprehending genetic information; (2 Comprehension of genetic information by pediatricians; (3 Genetics training in residency programs; and (4 The effect of genetic information on the future role of pediatricians and potential legal implications. Conclusion Pediatricians and residents lack essential knowledge of genetics and communication skills for effective counseling of patients. The review indicated that successful communication of genetic information involves a number of important skills and considerations. It is likely that these skills and considerations are universally required for the communication of most complex specialized medical information. In the past, communication skills have not been considered a priority. Today, these skills have become a
Full Text Available Marine environments have undergone large-scale changes in recent decades as a result of multiple anthropogenic pressures, such as overfishing, eutrophication, habitat fragmentation, etc., causing often nonlinear ecosystem responses. At the same time, management institutions lack the appropriate measures to address these abrupt transformations. We focus on existing examples from social-ecological systems of European seas that can be used to inform and advise future management. Examples from the Black Sea and the Baltic Sea on long-term ecosystem changes caused by eutrophication and fisheries, as well as changes in management institutions, illustrate nonlinear dynamics in social-ecological systems. Furthermore, we present two major future challenges, i.e., climate change and energy intensification, that could further increase the potential for nonlinear changes in the near future. Practical tools to address these challenges are presented, such as ensuring learning, flexibility, and networking in decision-making processes across sectors and scales. A combination of risk analysis with a scenario-planning approach might help to identify the risks of ecosystem changes early on and may frame societal changes to inform decision-making structures to proactively prevent drastic surprises in European seas.
Climate change, security of supply and local air pollution are among the challenges that are shaping the future of energy systems worldwide. In response to these challenges, various goals are set nationally and internationally that energy systems are supposed to fulfil. These include e.g. EU 20...... them. The challenges of climate change, security of supply, and local air pollution are addressed in the papers by focusing on renewable energy systems, demand side management options, climate change mitigation and resource potentials. In the process of the study the energy system optimisation models...... energy, and an increased climate change mitigation potential.Other results highlight among others, the possible future roles of individual technologies (i.e. wind power in Denmark and carbon capture and storage in China) in the climate constrained world, the difficulty to achieve the 2°C target agreed...
Singh, R; Kroesen, J.O.
The sustainable development in developing and newly industrialising countries (China, India, South Africa, and Brazil) is central issue for policy makers, decision makers, academic, and planners. The attainment of sustainability has become a challenge for rapidly urbanising India. The paper focuses on the challenges for building less energy consuming cities. The cities use different technologies for lighting purposes but which technology can decarbonise them in future. Moreover, the question ...
Evans, Lyndon R
The Large Hadron Collider (LHC) incorporates many technological innovations in order to achieve its design objectives at the lowest cost. The two-in-one magnet design, with the two magnetic channels integrated into a common yoke, has proved to be an economical alternative to two separate rings and allows enough free space in the existing (LEP) tunnel for a possible future re-installation of a lepton ring for e-p physics. In order to achieve the design energy of 7 TeV per beam, with a dipole field of 8.3 T, the superconducting magnet system must operate in superfluid helium at 1.9 K. This requires further development of cold compressors similar to those first used at CEBAF. The LHC will be the first hadron machine to produce appreciable synchrotron radiation which, together with the heat load due to image currents, has to be absorbed at cryogenic temperatures. Finally, the LHC is the first major CERN accelerator project built in collaboration with other laboratories. A brief review of the machine design is giv...
Yakub, Fitri; Md Khudzari, Ahmad Zahran; Mori, Yasuchika
This paper presents and studies various selected literature primarily from conference proceedings, journals and clinical tests of the robotic, mechatronics, neurology and biomedical engineering of rehabilitation robotic systems. The present paper focuses of three main categories: types of rehabilitation robots, key technologies with current issues and future challenges. Literature on fundamental research with some examples from commercialized robots and new robot development projects related to rehabilitation are introduced. Most of the commercialized robots presented in this paper are well known especially to robotics engineers and scholars in the robotic field, but are less known to humanities scholars. The field of rehabilitation robot research is expanding; in light of this, some of the current issues and future challenges in rehabilitation robot engineering are recalled, examined and clarified with future directions. This paper is concluded with some recommendations with respect to rehabilitation robots.
Shawn M Crump
Full Text Available There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode either ion channel pore-forming subunits or proteins that regulate aspects of ion channel biology such as function, trafficking and localization. The human KCNE gene family comprises five potassium channel regulatory subunits, sequence variants in each of which are associated with cardiac arrhythmias. KCNE gene products exhibit promiscuous partnering and in some cases ubiquitous expression, hampering efforts to unequivocally correlate each gene to specific native potassium currents. Likewise, deducing the molecular etiology of cardiac arrhythmias in individuals harboring rare KCNE gene variants, or more common KCNE polymorphisms, can be challenging. In this review we provide an update on putative arrhythmia-causing KCNE gene variants, and discuss current thinking and future challenges in the study of molecular mechanisms of KCNE-associated cardiac rhythm disturbances.
Zisman, Michael S
There are three types of future neutrino facilities currently under study, one based on decays of stored beta-unstable ion beams (?Beta Beams?), one based on decays of stored muon beams (?Neutrino Factory?), and one based on the decays of an intense pion beam (?Superbeam?). In this paper we discuss the challenges each design team must face and the R&D being carried out to turn those challenges into technical opportunities. A new program, the Muon Accelerator Program, has begun in the U.S. to carry out the R&D for muon-based facilities, including both the Neutrino Factory and, as its ultimate goal, a Muon Collider. The goals of this program will be briefly described.
Grossmann, Igor; Na, Jinkyung
Since the dawn of psychology as a science, conceptual and methodological questions have accompanied research at the intersection of culture and psychology. We review some of these questions using two dominant concepts-independent versus interdependent social orientation and analytic versus holistic cognitive style. Studying the relationship between culture and psychology can be difficult due to sampling restrictions and response biases. Since these challenges have been mastered, a wealth of research has accumulated on how culture influences cognition, emotion, and the self. Building on this work, we outline a set of new challenges for culture and psychology. Such challenges include questions about conceptual clarity, within-cultural and subcultural variations (e.g., variations due to social class), differentiation and integration of processes at the group versus individual level of analysis, modeling of how cultural processes unfold over time, and integration of insights from etic and emic methodological approaches. We review emerging work addressing these challenges, proposing that future research on culture and psychology is more exciting than ever. WIREs Cogn Sci 2014, 5:1-14. doi: 10.1002/wcs.1267 CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website.
Full Text Available The information society stays at the core of the Lisbon Strategy, despite the dot-com crisis and the still hidden macroeconomic impact of information and communication technology (ICT. Thus, i2010 has been the first concrete initiative of the revised Lisbon Strategy in 2005, while ICT represents by far the field with the largest budget in the 7th Framework Programme (FP7. On the industry side, the stakes are still high in the global competition, where Europe hopes for a place at least for communication technologies and services. However, the extreme dynamics of technology with its sometimes breathtaking promises, poses new challenges for e-inclusion. Firstly, the accelerating pace of innovation maintains a generation type of digital divide between countries with different level of development. Secondly, the changing nature of the network (e.g. web 2.0 with virtual communities; web 3.0 with location based interaction; semantic web; ambient intelligence and “the internet of things” blurs the very distinction between inside and outside the information space. The paper explores these challenges and the associated policy options.
Hayman, B.; Wedel-Heinen, J.; Brøndsted, Povl
, preventing buckling failure, ensuring adequate fatigue life under variable wind loading combined with gravitational loading, and minimizing the occurrence and consequences of production defects. A major challenge is to develop cost-effective ways to ensure that production defects do not cause unacceptable......The main concept currently in use in wind energy involves horizontal-axis wind turbines with blades of fiber composite materials. This turbine concept is expected to remain as the major provider of wind power in the foreseeable future. However, turbine sizes are increasing, and installation...
Leal Filho, Walter; Úbelis, Arnolds; Bērziņa, Dina
.... The book highlights sustainable development in relation to the knowledge society and smart future manufacturing technologies, and it helps provide a better understanding of the interplay between...
Pidgeon, Nick; Harthorn, Barbara; Satterfield, Terre
Nanotechnology involves the fabrication, manipulation, and control of materials at the atomic level and may also bring novel uncertainties and risks. Potential parallels with other controversial technologies mean there is a need to develop a comprehensive understanding of processes of public perception of nanotechnology uncertainties, risks, and benefits, alongside related communication issues. Study of perceptions, at so early a stage in the development trajectory of a technology, is probably unique in the risk perception and communication field. As such it also brings new methodological and conceptual challenges. These include: dealing with the inherent diversity of the nanotechnology field itself; the unfamiliar and intangible nature of the concept, with few analogies to anchor mental models or risk perceptions; and the ethical and value questions underlying many nanotechnology debates. Utilizing the lens of social amplification of risk, and drawing upon the various contributions to this special issue of Risk Analysis on Nanotechnology Risk Perceptions and Communication, nanotechnology may at present be an attenuated hazard. The generic idea of "upstream public engagement" for emerging technologies such as nanotechnology is also discussed, alongside its importance for future work with emerging technologies in the risk communication field. © 2011 Society for Risk Analysis.
Guze, Phyllis A
Medical education is rapidly changing, influenced by many factors including the changing health care environment, the changing role of the physician, altered societal expectations, rapidly changing medical science, and the diversity of pedagogical techniques. Changes in societal expectations put patient safety in the forefront, and raises the ethical issues of learning interactions and procedures on live patients, with the long-standing teaching method of "see one, do one, teach one" no longer acceptable. The educational goals of using technology in medical education include facilitating basic knowledge acquisition, improving decision making, enhancement of perceptual variation, improving skill coordination, practicing for rare or critical events, learning team training, and improving psychomotor skills. Different technologies can address these goals. Technologies such as podcasts and videos with flipped classrooms, mobile devices with apps, video games, simulations (part-time trainers, integrated simulators, virtual reality), and wearable devices (google glass) are some of the techniques available to address the changing educational environment. This article presents how the use of technologies can provide the infrastructure and basis for addressing many of the challenges in providing medical education for the future.
Guze, Phyllis A.
Medical education is rapidly changing, influenced by many factors including the changing health care environment, the changing role of the physician, altered societal expectations, rapidly changing medical science, and the diversity of pedagogical techniques. Changes in societal expectations put patient safety in the forefront, and raises the ethical issues of learning interactions and procedures on live patients, with the long-standing teaching method of “see one, do one, teach one” no longer acceptable. The educational goals of using technology in medical education include facilitating basic knowledge acquisition, improving decision making, enhancement of perceptual variation, improving skill coordination, practicing for rare or critical events, learning team training, and improving psychomotor skills. Different technologies can address these goals. Technologies such as podcasts and videos with flipped classrooms, mobile devices with apps, video games, simulations (part-time trainers, integrated simulators, virtual reality), and wearable devices (google glass) are some of the techniques available to address the changing educational environment. This article presents how the use of technologies can provide the infrastructure and basis for addressing many of the challenges in providing medical education for the future. PMID:26330687
Full Text Available The increasing complexity of the conventional grid due to population growth, advancement in technology and infrastructures which contribute immensely to instability, insecurity, and inefficiency and environmental energy sustainability calls for the use of renewable energy for sustainability of power supply. Intermittency and fluctuation of the renewable energy is a great challenge on the smart grid. This paper reveal the potential challenges of renewable energy on the smart grid and proffer solution with the application of high voltage DC (HVDC and Flexible AC transmission system (FACTS devices. The functions and advantages of FACTS devices are presented in this paper. Voltage control and stability control with FACTS application are also discussed. This was achieved because FACTS has fast controllability and capability to exchange active and reactive power independently.
The sustainable development of our future represents an unorthodox challenge in sciences and technologies.The exploration of unconventional chemical reactivities that could potentially result in more sustainable chemical productions with efficient utilization of resource and inherent prevention of waste will provide the foundation for the synthetic chemistry of our future.As part of this endeavor,we have explored metal-mediated reactions in water to minimize protection-deprotection and the use of organic solvents,catalytic nucleophilic additions via C-H reactions to avoid generation and use of stoichiometric organic halides and metal in water,and Cross-Dehydrogenative-Coupling (CDC) reactions to minimize overall transformation steps.
Döhring, Thorsten; Stollenwerk, Manfred; Gong, Qingqing; Proserpio, Laura; Winter, Anita; Friedrich, Peter
Previously used mirror technologies are not able to fulfil the requirements of future X-ray telescopes due to challenging requests from the scientific community. Consequently new technical approaches for X-ray mirror production are under development. In Europe the technical baseline for the planned X-ray observatory ATHENA is the radical new approach of silicon pore optics. NASÁs recently launched NuSTAR mission uses segmented mirrors shells made from thin bended glasses, successfully demonstrating the feasibility of the glass forming technology for X-ray mirrors. For risk mitigation also in Europe the hot slumping of thin glasses is being developed as an alternative technology for lightweight X-ray telescopes. The high precision mirror manufacturing requires challenging technical developments; several design trades and trend-setting decisions need to be made and are discussed within this paper. Some new technical and economic aspects of the intended glass mirror serial production are also studied within the recently started interdisciplinary project INTRAAST, an acronym for "industry transfer of astronomical mirror technologies". The goal of the project, embedded in a cooperation of the Max-Planck-Institute for extraterrestrial Physics and the University of Applied Sciences Aschaffenburg, is to master the challenge of producing thin mirror shells for future X-ray telescopes. As a first project task the development of low stress coatings for thin glass mirror substrates have been started, the corresponding technical approach and first results are presented.
Moore, Gwendolyn B.; Yin, Robert K.
A study to determine how three advanced technologies might be applied to the needs of special education students helped inspire the development of a new method for identifying such applications. This new method, named the "Hybrid Approach," combines features of the two traditional methods: technology-push and demand-pull. Technology-push involves…
LaFortune, K N; Hurd, R L; Fochs, S N; Rotter, M D; Pax, P H; Combs, R L; Olivier, S S; Brase, J M; Yamamoto, R M
The Solid-State, Heat-Capacity Laser (SSHCL) program at Lawrence Livermore National Laboratory is a multi-generation laser development effort scalable to the megawatt power levels with current performance approaching 100 kilowatts. This program is one of many designed to harness the power of lasers for use as directed energy weapons. There are many hurdles common to all of these programs that must be overcome to make the technology viable. There will be a in-depth discussion of the general issues facing state-of-the-art high energy lasers and paths to their resolution. Despite the relative simplicity of the SSHCL design, many challenges have been uncovered in the implementation of this particular system. An overview of these and their resolution are discussed. The overall system design of the SSHCL, technological strengths and weaknesses, and most recent experimental results will be presented.
Interest in high field dipoles has been given a boost by new proposals to build a high-energy proton-proton collider to follow the LHC and programs around the world are taking on the task to answer the need. Studies aiming toward future high-energy proton-proton colliders at the 100 TeV scale are now being organized. The LHC and current cost models are based on technology close to four decades old and point to a broad optimum of operation using dipoles with fields between 5 and 12T when site constraints, either geographical or political, are not a factor. Site geography constraints that limit the ring circumference can drive the required dipole field up to 20T, which is more than a factor of two beyond state-of-the-art. After a brief review of current progress, the talk will describe the challenges facing future development and present a roadmap for moving high field accelerator magnet technology forward. This work was supported by the Director, Office of Science, High Energy Physics, US Department of Energy, under contract No. DE-AC02-05CH11231.
Full Text Available This article focuses on challenges associated with the use of technology foresight for developing long-term strategies for innovative uses of ICT in education with an emphasis on the role of creativity. The outcomes of two international foresight programmes on the future of education are critically examined. The findings demonstrate the need to address programme participants’ capacity to engage in systematic futures thinking and to emphasise creative aspects of constructing shared visions of the future.
Sakamoto, H; The ATLAS collaboration
The ATLAS experiment has collected more than 25 fb-1 of data since LHC has started it's operation in 2010. Tens of petabytes of collision events and Monte-Carlo simulations are stored over more than 150 computing centers all over the world. The data processing is performed on grid sites providing more than 100.000 computing cores and orchestrated by the ATLAS in-house developed job and data management services. The discovery of the Higgs-like boson in 2012 would not be possible without the excellent performance of the ATLAS Distributed Computing. The future ATLAS experiment operation with increased LHC beam energy and luminosity foreseen for 2014 imposes a significant increase in computing demands the ATLAS Distributed Computing needs to satisfy. Therefore, a development of the new data-processing, storage and data-distribution systems has been started to efficiently use the computing resources exploiting current and future technologies of distributed computing.
Dobnik, David; Morisset, Dany; Gruden, Kristina
In the field of genetically modified organism (GMO) diagnostics, real-time PCR has been the method of choice for target detection and quantification in most laboratories. Despite its numerous advantages, however, the lack of a true multiplexing option may render real-time PCR less practical in the face of future GMO detection challenges such as the multiplicity and increasing complexity of new transgenic events, as well as the repeated occurrence of unauthorized GMOs on the market. In this context, we recently reported the development of a novel multiplex quantitative DNA-based target amplification method, named NASBA implemented microarray analysis (NAIMA), which is suitable for sensitive, specific and quantitative detection of GMOs on a microarray. In this article, the performance of NAIMA is compared with that of real-time PCR, the focus being their performances in view of the upcoming challenge to detect/quantify an increasing number of possible GMOs at a sustainable cost and affordable staff effort. Finally, we present our conclusions concerning the applicability of NAIMA for future use in GMO diagnostics.
Wetmore, Jameson M
Technological change does not happen in a vacuum; decisions about which technologies to develop, fund, market, and use engage ideas about values as well as calculations of costs and benefits. This anthology focuses on the interconnections of technology, society, and values. It offers writings by authorities as varied as Freeman Dyson, Laurence Lessig, Bruno Latour, and Judy Wajcman that will introduce readers to recent thinking about technology and provide them with conceptual tools, a theoretical framework, and knowledge to help understand how technology shapes society and how society shapes technology. It offers readers a new perspective on such current issues as globalization, the balance between security and privacy, environmental justice, and poverty in the developing world. The careful ordering of the selections and the editors' introductions give Technology and Society a coherence and flow that is unusual in anthologies. The book is suitable for use in undergraduate courses in STS and other disciplines...
DeVieneni, Alayna; Velez, Carlos Andres; Benjamin, David; Hollenbeck, Jay
Welcome to the HELIOS Technology Challenge Guide. This document is intended to serve as a general road map for participants of the HELIOS Technology Challenge [HTC] Program and the associated inaugural challenge: HTC-01: Cost-Effective Additive Manufacturing in Space. Please note that this guide is not a rule book and is not meant to hinder the development of innovative ideas. Its primary goal is to highlight the objectives of the HTC-01 Challenge and to describe possible solution routes and pitfalls that such technology may encounter in space. Please also note that participants wishing to demonstrate any hardware developed under this program during any future HELIOS Technology Challenge showcase event(s) may be subject to event regulations to be published separately at a later date.
S C Chetal; P Chellapandi
The paper brings out the advantages of fast breeder reactor and importance of developing closed nuclear fuel cycle for the large scale energy production, which is followed by its salient safety features. Further, the current status and future strategy of the fast reactor programme since the inception through 40 MWt/13 MWe Fast Breeder Test Reactor (FBTR), is highlighted. The challenges and achievements in science and technology of FBRs focusing on safety are described with the particular reference to 500 MWe capacity Prototype Fast Breeder Reactor (PFBR), being commissioned at Kalpakkam. Roadmap with comprehensive R&D for the large scale deployment of Sodium Cooled Fast Reactor (SFRs) and timely introduction of metallic fuel reactors with emphasis on breeding gain and enhanced safety are being brought out in this paper.
Kim, Yeni; Santos, Renata; Gage, Fred H.; Marchetto, Maria C.
Bipolar disorder (BD) is a chronic and progressive psychiatric illness characterized by mood oscillations, with episodes of mania and depression. The impact of BD on patients can be devastating, with up to 15% of patients committing suicide. This disorder is associated with psychiatric and medical comorbidities and patients with a high risk of drug abuse, metabolic and endocrine disorders and vascular disease. Current knowledge of the pathophysiology and molecular mechanisms causing BD is still modest. With no clear biological markers available, early diagnosis is a great challenge to clinicians without previous knowledge of the longitudinal progress of illness. Moreover, despite recommendations from evidence-based guidelines, polypharmacy is still common in clinical treatment of BD, reflecting the gap between research and clinical practice. A major challenge in BD is the development of effective drugs with low toxicity for the patients. In this review article, we focus on the progress made and future challenges we face in determining the pathophysiology and molecular pathways involved in BD, such as circadian and metabolic perturbations, mitochondrial and endoplasmic reticulum (ER) dysfunction, autophagy and glutamatergic neurotransmission; which may lead to the development of new drugs. PMID:28261061
Katoch, Rajan; Sethi, Amit; Thakur, Neelam; Murdock, Larry L
The research on the RNA interference (RNAi) for the control of insect pests has made significant growth in recent years. The availability of the genomic sequences of insects has further widened the horizons for the testing of this technology to various insect groups. Different modes of application of double-stranded RNA (dsRNA) have been tested; however, the practicability of delivery of dsRNA in insects still remains the biggest challenge. Till date, the oral delivery of dsRNA in insects is one of the efficient approaches for the practical application of this technique. The uptake of dsRNA from the insect gut is mediated either by SID-1/SID-2 transmembrane proteins or by endocytosis; however, the systemic RNAi machinery still remains to be revealed in insect species. The RNAi-mediated gene knockdown has shown striking results in different insect groups, pointing it to be the upcoming technique for insect control. However, before the successful application of this technique for insect control, some potential issues need to be resolved. This review presents the account of prospects and challenges for the use of this technology for insect control.
Robinson, S M
Understanding the role and importance of nutrition in early postnatal life, as an influence on lifelong vulnerability to poor health, is an important part of current research. We need to be able to define optimal patterns of infant feeding, not just to support growth and development in infancy, but also as determinants of later health. To date, much of the focus on the long-term effects of infant nutrition has been on milk feeding, to compare breast and formula feeding and to evaluate the effects of exclusivity, timing and duration of feeding different types of milk in infancy; other aspects of infant feeding such as age at introduction of solid foods and type of weaning diet have received less attention, and relatively little is known about their links to later health. Contemporary data are needed to enable us to move beyond explanation of historical infant feeding data in order to understand and predict health outcomes in future generations. Ongoing and new population studies, that include infants from diverse settings, will be key to providing generalizable data that can be used to define optimal feeding practice. There are some methodological challenges ahead, although significant progress has already been made, and further progress is envisaged in the future. In particular, the opportunity to bring together epidemiological studies and new mechanistic insights that will help identify key aspects of infant nutrition and their causal effects offer great promise both in moving this field forward as well as the potential for health benefits for future generations.
Full Text Available Mobile and ubiquitous technologies can potentially change the role of information and communication technology in human lives. Empirical, human-centered approaches are emerging as an alternative to technology-driven approaches in the innovation of these technologies. Three necessary empirical stages, intertwined with analytical ones and with each informing and grounding the succeeding stages, are analyzed. First, needfinding is utilized to discover societal and individual demands for technology. Second, observational and experimental studies examine the social and cognitive preconditions for interaction. From these two steps, a hypothesis is formulated regarding how technology will change existing practices. Finally, this hypothesis, embodied in the design of a prototype, is tested in a field trial. Four design cases illustrate the value of empirical grounding.
Afzal, Adeel; Abuilaiwi, Faraj A.; Habib, Amir; Awais, Muhammad; Waje, Samaila B.; Atieh, Muataz A.
The supercapacitors are advanced electrochemical energy storage devices having characteristics such as high storage capacity, rapid delivery of charge, and long cycle life. Polypyrrole (PPy) - an electronically conducting polymer, and carbon nanotubes (CNT) with high surface area and exceptional electrical and mechanical properties are among the most frequently studied advanced electrode materials for supercapacitors. The asymmetric supercapacitors composed of PPy/CNT composite electrodes offer complementary benefits to improve the specific capacitance, energy density, and stability. This article presents an overview of the recent technological advances in PPy/CNT composite supercapacitors and their limitations. Various strategies for synthesis and fabrication of PPy/CNT composites are discussed along with the factors that influence their ultimate electrochemical performance. The drawbacks and challenges of modern PPy/CNT composite supercapacitors are also reviewed, and potential areas of concern are identified for future research and development.
Full Text Available Digital technology has transformed the information flow and support infrastructure for numerous application domains, such as cellular communications. Cinematography, traditionally, a film based medium, has embraced digital technology leading to innovative transformations in its work flow. Digital cinema supports transmission of high resolution content enabled by the latest advancements in optical communications and video compression. In this paper we provide a survey of the optical network technologies for supporting this bandwidth intensive traffic class. We also highlight the significance and benefits of the state of the art in optical technologies that support the digital cinema work flow.
Allison, Stephen W [ORNL; Lapsa, Melissa Voss [ORNL; Ward, Christina D [ORNL; Smith, Barton [ORNL; Grubb, Kimberly R [ORNL; Lee, Russell [ORNL
The generally acknowledged sources of renewable energy are wind, geothermal, biomass, solar, hydropower, and hydrogen. Renewable energy technologies are crucial to the production and utilization of energy from these regenerative and virtually inexhaustible sources. Furthermore, renewable energy technologies provide benefits beyond the establishment of sustainable energy resources. For example, these technologies produce negligible amounts of greenhouse gases and other pollutants in providing energy, and they exploit domestically available energy sources, thereby reducing our dependence on both the importation of fossil fuels and the use of nuclear fuels. The market price of renewable energy technologies does not reflect the economic value of these added benefits.
Full Text Available Telecytology is the interpretation of cytology material at a distance using digital images. For more than a decade, pioneering efforts to introduce telecytology into clinical practice have been reported. A Medline search for "telecytology" and "cytology" reveals a voluminous literature, though much of what has been published to date is based on technologies that are rapidly becoming obsolete. The technological limitations of previous techniques, including the transmission of static digital images and dynamic streaming images, have limited telecytology to minor niches. The primary problem with these technologies is that the remote viewer can only see a small fraction of the material on the original slides, introducing the possibility of diagnostic error based not only on image quality but also on image selection. Remote robotic microscopy offers one possible solution to this problem, but to date has found limited acceptance, principally attributable to slow operating times. Whole slide imaging seems to be a much more promising solution, though cytology-specific literature regarding its use is still scant. The advent of whole slide imaging opens up new possibilities for telecytology by enabling high-quality images of entire cytology specimens to be available to anyone, anywhere via the Internet. Although challenges remain, especially with regard to capturing the full microscopy experience including multiple planes of focus and sharp high-powered images, rapidly advancing technology promises to overcome these limitations. Increasing application of whole slide imaging technology in surgical pathology will undoubtedly also increase its application to cytology due to the increasing affordability and practicality of the equipment as it serves a larger number of useful roles within a pathology department. The current and expanding applications of telecytology for clinical practice, education, quality assurance, and testing will be reviewed.
This paper is a snapshot of an evolving vision of what the future may hold for learning technology. It offers three personal visions of the future and raises many questions that need to be explored if learning technology is to realise its full potential.
... ADMINISTRATION Future Systems Technology Advisory Panel Meeting AGENCY: Social Security Administration (SSA...:30 a.m.-12 p.m. Location: The Latham Hotel Georgetown. ADDRESSES: 3000 M Street, Northwest... independent advice and recommendations on the future of systems technology and electronic services at the...
Full Text Available Jalil Safaei Department of Economics, University of Northern British Columbia, Prince George, BC, CanadaBackground: There is a vast body of literature on deliberative, participative, or engaged democracy. In the area of health care there is a rapidly expanding literature on deliberative democracy as embodied in various notions of public engagement, shared decision-making (SDM, patient-centered care, and patient/care provider autonomy over the past few decades. It is useful to review such literature to get a sense of the challenges and prospects of introducing deliberative democracy in health care.Objective: This paper reviews the key literature on deliberative democracy and SDM in health care settings with a focus on identifying the main challenges of promoting this approach in health care, and recognizing its progress so far for mapping out its future prospects in the context of advanced countries.Method: Several databases were searched to identify the literature pertinent to the subject of this study. A total of 56 key studies in English were identified and reviewed carefully for indications and evidence of challenges and/or promising avenues of promoting deliberative democracy in health care.Results: Time pressure, lack of financial motivation, entrenched professional interests, informational imbalance, practical feasibility, cost, diversity of decisions, and contextual factors are noted as the main challenges. As for the prospects, greater clarity on conception of public engagement and policy objectives, real commitment of the authorities to public input, documenting evidence of the effectiveness of public involvement, development of patient decision supports, training of health professionals in SDM, and use of multiple and flexible methods of engagement leadership suited to specific contexts are the main findings in the reviewed literature.Conclusion: Seeking deliberative democracy in health care is both challenging and rewarding. The
Committee on America's Energy Future; National Academy of Sciences; National Academy of Engineering
... are increasingly concentrated in geopolitically unstable regions. The country's challenge is to develop an energy portfolio that addresses these concerns while still providing sufficient, affordable energy reserves for the nation...
In the past two decades, economic, technological, demographic, and political forces have stimulated major change in the learning and working landscape for young people. Understanding how to use computers and other technology for learning, productivity, and performance has become as fundamental to a person's ability to navigate through school and…
Tenney, Darrel R.; Davis, John G., Jr.; Pipes, R. Byron; Johnston, Norman
Composite materials have emerged as the materials of choice for increasing the performance and reducing the weight and cost of military, general aviation, and transport aircraft and space launch vehicles. Major advancements have been made in the ability to design, fabricate, and analyze large complex aerospace structures. The recent efforts by Boeing and Airbus to incorporate composite into primary load carrying structures of large commercial transports and to certify the airworthiness of these structures is evidence of the significant advancements made in understanding and use of these materials in real world aircraft. NASA has been engaged in research on composites since the late 1960 s and has worked to address many development issues with these materials in an effort to ensure safety, improve performance, and improve affordability of air travel for the public good. This research has ranged from synthesis of advanced resin chemistries to development of mathematical analyses tools to reliably predict the response of built-up structures under combined load conditions. The lessons learned from this research are highlighted with specific examples to illustrate the problems encountered and solutions to these problems. Examples include specific technologies related to environmental effects, processing science, fabrication technologies, nondestructive inspection, damage tolerance, micromechanics, structural mechanics, and residual life prediction. The current state of the technology is reviewed and key issues requiring additional research identified. Also, grand challenges to be solved for expanded use of composites in aero structures are identified.
Full Text Available The miniaturization and virtualization processes drive converging technologies from interactions between the NBIC (Nano, Bio, Info, and Cogno technologies. The converging technologies stimulate innovation, promote research and development in different fields and produce revolutionary progresses in medicine. These technologies enable us to create contacts between brains and machines, the growth in molecular nanotechnology, the construction of respirocytes, chromallocytes, clottocytes, nanorobotic phagocytes, and nanobots. Nanobots would enter the nucleus of a cell and extract all of the genetic material and replace it with a synthetically produced copy of the original that has been manufactured in a laboratory to contain only non-defective base-pairs. It is predicted that “the regenerative medicine”, as a megatrend, will have an enormous effect on medical technologies and clinical sciences. Regenerative medicine is an application field of converging technologies in translational medicine. It attempts to translate the results of tissue engineering to construct 3D tissues and organs. Regenerative medicine is also an exciting field for induced pluripotent stem cell (iPSC and promises to bring about a paradigm shift to health care. Accumulating evidence indicates that converging technologies will offer great potentials for regenerative medicine to create innovative treatments for diseases that the traditional therapies have not been effective yet.
Wilkins, Michael J; Daly, Rebecca A; Mouser, Paula J; Trexler, Ryan; Sharma, Shihka; Cole, David R; Wrighton, Kelly C; Biddle, Jennifer F; Denis, Elizabeth H; Fredrickson, Jim K; Kieft, Thomas L; Onstott, Tullis C; Peterson, Lee; Pfiffner, Susan M; Phelps, Tommy J; Schrenk, Matthew O
Research in the deep terrestrial biosphere is driven by interest in novel biodiversity and metabolisms, biogeochemical cycling, and the impact of human activities on this ecosystem. As this interest continues to grow, it is important to ensure that when subsurface investigations are proposed, materials recovered from the subsurface are sampled and preserved in an appropriate manner to limit contamination and ensure preservation of accurate microbial, geochemical, and mineralogical signatures. On February 20th, 2014, a workshop on "Trends and Future Challenges in Sampling The Deep Subsurface" was coordinated in Columbus, Ohio by The Ohio State University and West Virginia University faculty, and sponsored by The Ohio State University and the Sloan Foundation's Deep Carbon Observatory. The workshop aims were to identify and develop best practices for the collection, preservation, and analysis of terrestrial deep rock samples. This document summarizes the information shared during this workshop.
Anastas, Paul T; Kirchhoff, Mary M
Over the course of the past decade, green chemistry has demonstrated how fundamental scientific methodologies can protect human health and the environment in an economically beneficial manner. Significant progress is being made in several key research areas, such as catalysis, the design of safer chemicals and environmentally benign solvents, and the development of renewable feedstocks. Current and future chemists are being trained to design products and processes with an increased awareness for environmental impact. Outreach activities within the green chemistry community highlight the potential for chemistry to solve many of the global environmental challenges we now face. The origins and basis of green chemistry chart a course for achieving environmental and economic prosperity inherent in a sustainable world.
He, Nongyue; Zeng, Xin; Wang, Weida; Deng, Kunlong; Pan, Yunzhi; Xiao, Li; Zhang, Jia; Li, Kai
Gene therapy is a genetic intervention used for the prevention or treatment of diseases by targeting selected genes with specific nucleotides. The most common form of gene therapy involves the establishment of a function by transfer of functional genes or correction of mutated genes. In other situations, suppression or abolishment of a function is required in order to balance a complicated regulatory system or to deplete cellular molecules crucial for pathogen infection. The latter in fact employs an opposite strategy compared to those used in classical gene therapy, and can be defined as reversed gene therapy. This paper takes CCR5-based stem cell gene therapy as an example to discuss the challenges and future expectations of reversed gene therapy.
Wilkins, Michael J.; Daly, Rebecca; Mouser, Paula J.; Trexler, Ryan; Sharma, Shihka; Cole, David R.; Wrighton, Kelly C.; Biddle , Jennifer F.; Denis, Elizabeth; Fredrickson, Jim K.; Kieft, Thomas L.; Onstott, T. C.; Peterson, Lee; Pfiffner, Susan M.; Phelps, Tommy J.; Schrenk, Matthew O.
Research in the deep terrestrial biosphere is driven by interest in novel biodiversity and metabolisms, biogeochemical cycling, and the impact of human activities on this ecosystem. As this interest continues to grow, it is important to ensure that when subsurface investigations are proposed, materials recovered from the subsurface are sampled and preserved in an appropriate manner to limit contamination and ensure preservation of accurate microbial, geochemical, and mineralogical signatures. On February 20th, 2014, a workshop on “Trends and Future Challenges in Sampling The Deep Subsurface” was coordinated in Columbus, Ohio by The Ohio State University and West Virginia University faculty, and sponsored by The Ohio State University and the Sloan Foundation’s Deep Carbon Observatory. The workshop aims were to identify and develop best practices for the collection, preservation, and analysis of terrestrial deep rock samples. This document summarizes the information shared during this workshop.
Full Text Available In the last decade there has been a significant increase in the interest of the educational and scientific community on cyberbullying, a new form of peer abuse and intimidation. Despite the widespread proliferation of studies and assessment tools on the phenomenon, there are still major conceptual and methodological gaps. This paper offers a comprehensive and updated review of the results of research on the definition of the construct, its prevalence and its impact on the people involved. Finally, it focuses specifically on the assessment of the construct and provides a brief review of the general and psychometric characteristics of the instruments used in some of the most relevant national and international studies conducted on the subject. This work places special emphasis on the present and future challenges and concludes with a number of general recommendations intended to guide the correct selection and/or construction of assessment instruments in this field of study.
Peeran, Syed Wali; Altaher, Omar Basheer; Peeran, Syed Ali; Alsaid, Fatma Mojtaba; Mugrabi, Marei Hamed; Ahmed, Aisha Mojtaba; Grain, Abdulgader
Libya is a vast country situated in North Africa, having a relatively better functioning economy with a scanty population. This article is the first known attempt to review the current state of oral health care in Libya and to explore the present trends and future challenges. Libyan health system, oral health care, and human resources with the present status of dental education are reviewed comprehensively. A bibliographic study of oral health research and publications has been carried out. The results point toward a common indicator that oral health-related research is low. Strategies have to be developed to educate the medical and dental professionals, to update the current curriculum and enable the system to be competent in all aspects of oral health care management.
Michael J Wilkins
Full Text Available Research in the deep terrestrial biosphere is driven by interest in novel biodiversity and metabolisms, biogeochemical cycling, and the impact of human activities on this ecosystem. As this interest continues to grow, it is important to ensure that when subsurface investigations are proposed, materials recovered from the subsurface are sampled and preserved in an appropriate manner to limit contamination and ensure preservation of accurate microbial, geochemical, and mineralogical signatures. On February 20th, 2014, a workshop on Trends and Future Challenges in Sampling The Deep Subsurface was coordinated in Columbus, Ohio by The Ohio State University and West Virginia University faculty, and sponsored by The Ohio State University and the Sloan Foundation’s Deep Carbon Observatory. The workshop aims were to identify and develop best practices for the collection, preservation, and analysis of terrestrial deep rock samples. This document summarizes the information shared during this workshop.
Dries, Billy; Jonkers, Ilse; Dingemanse, Walter; Vanwanseele, Benedicte; Vander Sloten, Jos; van Bree, Henri; Gielen, Ingrid
Musculoskeletal models have proven to be a valuable tool in human orthopaedics research. Recently, veterinary research started taking an interest in the computer modelling approach to understand the forces acting upon the canine musculoskeletal system. While many of the methods employed in human musculoskeletal models can applied to canine musculoskeletal models, not all techniques are applicable. This review summarizes the important parameters necessary for modelling, as well as the techniques employed in human musculoskeletal models and the limitations in transferring techniques to canine modelling research. The major challenges in future canine modelling research are likely to centre around devising alternative techniques for obtaining maximal voluntary contractions, as well as finding scaling factors to adapt a generalized canine musculoskeletal model to represent specific breeds and subjects.
Soukoulis, Costas M
Photonic metamaterials are man-made structures composed of tailored micro- or nanostructured metallo-dielectric sub-wavelength building blocks that are densely packed into an effective material. This deceptively simple, yet powerful, truly revolutionary concept allows for achieving novel, unusual, and sometimes even unheard-of optical properties, such as magnetism at optical frequencies, negative refractive indices, large positive refractive indices, zero reflection via impedance matching, perfect absorption, giant circular dichroism, or enhanced nonlinear optical properties. Possible applications of metamaterials comprise ultrahigh-resolution imaging systems, compact polarization optics, and cloaking devices. This review describes the experimental progress recently made fabricating three-dimensional metamaterial structures and discusses some remaining future challenges.
Gómez-Pérez, Asunción; Martínez-Romero, Marcos; Rodríguez-González, Alejandro; Vázquez, Guillermo; Vázquez-Naya, José M
Recent years have seen a dramatic increase in the amount and availability of data in the diverse areas of medicinal chemistry, making it possible to achieve significant advances in fields such as the design, synthesis and biological evaluation of compounds. However, with this data explosion, the storage, management and analysis of available data to extract relevant information has become even a more complex task that offers challenging research issues to Artificial Intelligence (AI) scientists. Ontologies have emerged in AI as a key tool to formally represent and semantically organize aspects of the real world. Beyond glossaries or thesauri, ontologies facilitate communication between experts and allow the application of computational techniques to extract useful information from available data. In medicinal chemistry, multiple ontologies have been developed during the last years which contain knowledge about chemical compounds and processes of synthesis of pharmaceutical products. This article reviews the principal standards and ontologies in medicinal chemistry, analyzes their main applications and suggests future directions.
This paper provides an overview of the status of educational technology in Turkey. In the face of severe social and economic challenges, many developing nations, including Turkey, are looking to education as a potential remedy. Recognizing that in an increasingly technology-dependent world, information and communications technology skills and…
Ortiz de Lejarazu, Raúl; Tamames, Sonia
Seasonal influenza is an annual challenge for health-care systems, due to factors such as co-circulation of 2 influenza A subtypes jointly with 2 influenza B lineages; the antigenic drift of these virus, which eludes natural immunity, as well as immunity conferred by vaccination; together with influenza impact in terms of morbidity and mortality. Influenza vaccines have been available for more than 70 years and they have progressed in formulation, production and delivery route. Recommendations on vaccination are focused on those with a higher probability of severe disease, and have a progressively wider coverage, and classically based on inactivated vaccines, but with an increasing importance of attenuated live vaccines. More inactivated vaccines are becoming available, from adyuvanted and virosomal vaccines to intradermal delivery, cell-culture or quadrivalent. Overall vaccine effectiveness is about 65%, but varies depending on characteristics of vaccines, virus, population and the outcomes to be prevented, and ranges from less than 10% to almost 90%. Future challenges are formulations that confer more extensive and lasting protection, as well as increased vaccination coverage, especially in groups such as pregnant women and health-care professionals, as well as being extended to paediatrics. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
Full Text Available Stimulated by wide-ranging theories on its cultural and economic significance, the history of early modern consumption in the Low Countries has received a remarkable amount of attention in historiography during the last three decades. During this period the growing body of empirical evidence, as well as shifting theoretical frameworks, have gradually altered our understanding of early modern patterns of consumption, their causes and consequences. The current article presents a review of the main tendencies in the field of early modern consumption history, and the challenges to this historiographical field these have presented. Based on these challenges, the article suggests new avenues for future research. Vroegmoderne consumptiegeschiedenis. Hedendaagse uitdagingen entoekomstperspectievenGestimuleerd door verstrekkende nieuwe theorieën over haar cultureleen economische betekenis, heeft de historiografie met betrekking totvroegmoderne consumptie in de Nederlanden op opmerkelijk veel aandacht mogen rekenen tijdens de voorbije drie decennia. Daarbij hebben zowel een groeiende beschikbaarheid van empirisch bronnenmateriaal, als verschuivende theoretische perspectieven, geleidelijk aan ons begrip van vroegmoderne consumptiepatronen, en hun oorzaken en gevolgen grondig veranderd. Het huidige artikel biedt een overzicht van de belangrijkste tendensen in het domein van de vroegmoderne consumptiegeschiedenis, gevolgd door nieuwe uitdagingen en toekomstperspectieven.
Bruce, Betram C.
Describes a course on the use of technologies for learning that studies the World Wide Web, multimedia, communication and collaboration software, tutoring systems, virtual reality, and other new digital technologies. Explores what educators are beginning to learn from this investigation of the past and future of learning technologies through use…
Full Text Available Continuous glucose monitoring (CGM sensors are portable devices that allow measuring and visualizing the glucose concentration in real time almost continuously for several days and are provided with hypo/hyperglycemic alerts and glucose trend information. CGM sensors have revolutionized Type 1 diabetes (T1D management, improving glucose control when used adjunctively to self-monitoring blood glucose systems. Furthermore, CGM devices have stimulated the development of applications that were impossible to create without a continuous-time glucose signal, e.g., real-time predictive alerts of hypo/hyperglycemic episodes based on the prediction of future glucose concentration, automatic basal insulin attenuation methods for hypoglycemia prevention, and the artificial pancreas. However, CGM sensors’ lack of accuracy and reliability limited their usability in the clinical practice, calling upon the academic community for the development of suitable signal processing methods to improve CGM performance. The aim of this paper is to review the past and present algorithmic challenges of CGM sensors, to show how they have been tackled by our research group, and to identify the possible future ones.
Okuyama, Namiko; Tamada, Koji; Tamura, Hideto
Remarkable advances have been made in cancer immunotherapy. Recent treatment strategies, especially chimeric antigen receptor-T (CAR-T) cell therapy and immune checkpoint inhibitors, reportedly achieve higher objective responses and better survival rates than previous immunotherapies for patients with treatment-resistant malignancies, creating a paradigm shift in cancer treatment. Several clinical trials of cancer immunotherapy for patients with various malignancies are ongoing. However, those with certain malignancies, such as low-immunogenic cancers, cannot be successfully treated with T-cell immunotherapy, and subsets of immunotherapy-treated patients relapse, meaning that more effective immunotherapeutic strategies are needed for such patients. Furthermore, the safety, convenience, and cost of cancer immunotherapy need to be improved in the near future. Herein, we discuss recent advances and future challenges in cancer immunotherapy, i.e., the identification of neoantigens for the development of individualized immunotherapies, the development of new CAR-T cell therapies, including so-called armored CAR-T cells that can induce greater clinical effects and thereby achieve longer survival, the development of off-the-shelf treatment regimens using non-self cells or cell lines, and effective cancer immunotherapy combinations.
Keus, Samyra H J; Munneke, Marten; Nijkrake, Maarten J; Kwakkel, Gert; Bloem, Bastiaan R
Even with optimal medical management using drugs or neurosurgery, patients with Parkinson's disease (PD) are faced with progressively increasing mobility problems. For this reason, many patients require additional physical therapy. Here, we review the professional evolution and scientific validation of physical therapy in PD, and highlight several future challenges. To gain insight in ongoing, recently completed or published trials and systematic reviews, we performed a structured literature review and contacted experts in the field of physical therapy in PD. Following publication of the first controlled clinical trial in 1981, the quantity and quality of clinical trials evaluating the efficacy of physical therapy in PD has evolved rapidly. In 2004 the first guideline on physical therapy in PD was published, providing recommendations for evidence-based interventions. Current research is aiming to gather additional evidence to support specific intervention strategies such as the prevention of falls, and to evaluate the implementation of evidence into clinical practice. Although research focused on physical therapy for PD is a relatively young field, high-quality supportive evidence is emerging for specific therapeutic strategies. We provide some recommendations for future research, and discuss innovative strategies to improve the organization of allied health care in PD, making evidence-based care available to all PD patients.
Aljadhey, Hisham; Mahmoud, Mansour Adam; Hassali, Mohamed Azmi; Alrasheedy, Alian; Alahmad, Amjad; Saleem, Fahad; Sheikh, Aziz; Murray, Michael; Bates, David W
Medication safety is a global concern among healthcare providers. However, the challenges to and the future of medication safety in Saudi Arabia have not been explored. We explored the perspectives of healthcare practitioners on current issues about medication safety in hospitals and community settings in Saudi Arabia in order to identify challenges to improving it and explore the future of medication safety practice. A total of 65 physicians, pharmacists, academics and nurses attended a one-day meeting in March 2010, designed especially for the purpose of this study. The participants were divided into nine round-table discussion sessions. Three major themes were explored in these sessions, including: major factors contributing to medication safety problems, challenges to improving medication safety practice, and participants' suggestions for improving medication safety. The round-table discussion sessions were videotaped and transcribed verbatim and analyzed by two independent researchers. The round-table discussions revealed that major factors contributing to medication safety problems included unrestricted public access to medications from various hospitals and community pharmacies, communication gaps between healthcare institutions, limited use of important technologies such as computerized provider order entry, and the lack of medication safety programs in hospitals. Challenges to current medication safety practice identified by participants included underreporting of medication errors and adverse drug reactions, multilingualism and differing backgrounds of healthcare professionals, lack of communication between healthcare providers and patients, and high workloads. Suggestions for improving medication safety practices in Saudi Arabia included continuous education for healthcare professionals and competency assessment focusing on medication safety, development of a culture that encourages medication error and adverse drug reactions reporting, use of technology
Wright, D. J.; Dibiase, D.; Harvey, F.; Solem, M.
Professionalism in today's rapidly-growing, multidisciplinary geographic information science field (e.g., geographic information systems or GIS, remote sensing, cartography, quantitative spatial analysis), now involves a commitment to ethical practice as informed by a more sophisticated understanding of the ethical implications of geographic technologies. The lack of privacy introduced by mobile mapping devices, the use of GIS for military and surveillance purposes, the appropriate use of data collected using these technologies for policy decisions (especially for conservation and sustainability) and general consequences of inequities that arise through biased access to geospatial tools and derived data all continue to be challenging issues and topics of deep concern for many. Students and professionals working with GIS and related technologies should develop a sound grasp of these issues and a thorough comprehension of the concerns impacting their use and development in today's world. However, while most people agree that ethics matters for GIS, we often have difficulty putting ethical issues into practice. An ongoing project supported by NSF seeks to bridge this gap by providing a sound basis for future ethical consideration of a variety of issues. A model seminar curriculum is under development by a team of geographic information science and technology (GIS&T) researchers and professional ethicists, along with protocols for course evaluations. In the curricula students first investigate the nature of professions in general and the characteristics of a GIS&T profession in particular. They hone moral reasoning skills through methodical analyses of case studies in relation to various GIS Code of Ethics and Rules of Conduct. They learn to unveil the "moral ecologies" of a profession through actual interviews with real practitioners in the field. Assignments thus far include readings, class discussions, practitioner interviews, and preparations of original case
Hemmat, Morteza; Ayatollahi, Haleh; Maleki, Mohammad Reza; Saghafi, Fatemeh
Currently, information technology is considered an important tool to improve healthcare services. To adopt the right technologies, policy makers should have adequate information about present and future advances. This study aimed to review and compare studies with a focus on the future of health information technology. This review study was completed in 2015. The databases used were Scopus, Web of Science, ProQuest, Ovid Medline, and PubMed. Keyword searches were used to identify papers and materials published between 2000 and 2015. Initially, 407 papers were obtained, and they were reduced to 11 papers at the final stage. The selected papers were described and compared in terms of the country of origin, objective, methodology, and time horizon. The papers were divided into two groups: those forecasting the future of health information technology (seven papers) and those providing health information technology foresight (four papers). The results showed that papers related to forecasting the future of health information technology were mostly a literature review, and the time horizon was up to 10 years in most of these studies. In the health information technology foresight group, most of the studies used a combination of techniques, such as scenario building and Delphi methods, and had long-term objectives. To make the most of an investment and to improve planning and successful implementation of health information technology, a strategic plan for the future needs to be set. To achieve this aim, methods such as forecasting the future of health information technology and offering health information technology foresight can be applied. The forecasting method is used when the objectives are not very large, and the foresight approach is recommended when large-scale objectives are set to be achieved. In the field of health information technology, the results of foresight studies can help to establish realistic long-term expectations of the future of health information
Within a fully interconnected world, the distinct relationship between end users, consumers and providers rapidly changes towards a scenario of collaboration and competition of multiple parties within one system. ‘Convergence’, ‘ubiquitous’ and ‘smart’ are key words describing future networks...
Offering a comprehensive overview of the challenges, risks and options facing the future of mechatronics, this book provides insights into how these issues are currently assessed and managed. Building on the previously published book ‘Mechatronics in Action,’ it identifies and discusses the key issues likely to impact on future mechatronic systems. It supports mechatronics practitioners in identifying key areas in design, modeling and technology and places these in the wider context of concepts such as cyber-physical systems and the Internet of Things. For educators it considers the potential effects of developments in these areas on mechatronic course design, and ways of integrating these. Written by experts in the field, it explores topics including systems integration, design, modeling, privacy, ethics and future application domains. Highlighting novel innovation directions, it is intended for academics, engineers and students working in the field of mechatronics, particularly those developing new conc...
Full Text Available This article addresses the state of the art of bioleaching research published in South Korean Journals. Our research team reviewed the available articles registered in the Korean Citation Index (KCI, Korean Journal Database addressing the relevant aspects of bioleaching. We systematically categorized the target metal sources as follows: mine tailings, electronic waste, mineral ores and metal concentrates, spent catalysts, contaminated soil, and other materials. Molecular studies were also addressed in this review. The classification provided in the present manuscript details information about microbial species, parameters of operation (e.g., temperature, particle size, pH, and process length, and target metals to compare recoveries among the bioleaching processes. The findings show an increasing interest in the technology from research institutes and mineral processing-related companies over the last decade. The current research trends demonstrate that investigations are mainly focused on determining the optimum parameters of operations for different techniques and minor applications at the industrial scale, which opens the opportunity for greater technological developments. An overview of bioleaching of each metal substrate and opportunities for future research development are also included.
Preeti Nigam, Joshi, E-mail: firstname.lastname@example.org [Combichem Bioresource Center, National Chemical Laboratory, Pune (India)
Nanotechnology is a paradigm for emerging technologies and much talked about area of science. It is the technology of future and has revolutionized all fields of medicine, agriculture, environmental and electronics by providing abilities that would never have previously dreamt of. It is a unique platform of multidisciplinary approaches integrating diverse fields of engineering, biology, physics and chemistry. In recent years, nanotechnology has seen the fastest pace in its all aspects of synthesis methodologies and wide applications in all areas of medicine, agricultural, environmental, and electronics. It is the impact of nanotechnology approaches that new fields of nanomedicine, cancer nanotechnology, nanorobotics and nanoelectronics have been emerged and are flourishing with the advances in this expanding field. Nanotechnology holds the potential for pervasive and promising applications and getting significant attention and financial aids also. Although there are different definitions of nanotechnology, in broad prospective, nanotechnology can be described as designing or exploiting materials at nanometer dimensions (i.e., one dimension less than 100 nanometers). At nanoscale, substances have a larger surface area to volume ratio than conventional materials which is the prime reason behind their increased level of reactivity, improved and size tunable magnetic, optical and electrical properties and more toxicity also.
Yadon, James N.; Steeb, Ralph V.
Focus in this paper is on the importance of materials technology, the matter and energy crises, and the interrelatedness of our increasing need for materials, and the implications for education. Following a short history of what materials have done for man and what man has done with materials, particularly in the development of various metals and…
Peer Competitors • Security of Global Commons (Cyber/Piracy) • Climate Change & Natural Disasters • Revised Defense Strategy, Re-Balance to Pacific... corn for disruptive technologies Laser Cooling Spintronics Bz 1st U.S. Intel satellite GRAB Semiconductors GaAs, GaN, SiC GPS
Hazelton, Andrew J.; Wüest, Andrea; Hughes, Greg; Litt, Lloyd C.; Goodwin, Frank
The cost of ownership (COO) of candidate technologies for 32 nm and 22 nm half-pitch lithography is calculated. To more accurately compare technologies with different numbers of process steps, a model that includes deposition, etching, metrology, and other costs is created. Results show lithography COO for leading edge layers will increase by roughly 50% from the 45 nm to the 32 nm half-pitch nodes. Double patterning and extreme ultraviolet lithography (EUVL) technologies have roughly the same COO under certain conditions. For 22 nm half-pitch nodes, EUVL has a significant cost advantage over other technologies under certain mask cost assumptions. Double patterning, however, may be competitive under worst case EUVL mask cost assumptions. Sensitivity studies of EUVL COO to throughput and uptime show EUVL may be cost-competitive at lower uptime and throughput conditions. In spite of these higher costs, total lithography costs for 32 nm and 22 nm half-pitches remain within reach of the Moore's Law trend. Finally, the COO of 450 mm lithography is calculated and shows the expected cost reduction is between 0% and 15%.
Schönwälder, Jürgen; Schonwalder, J.; Pras, Aiko; Martin-Flatin, Jean-Philippe
As the Internet continues to grow, it becomes more and more apparent that existing Internet management technologies need to be improved, extended or replaced in order to extend functionality and reduce development time and operational costs. Within the IETF, IRTF, and IAB, several new approaches are
Bagwell, James W.; Mahle, Christoph E.
Technology, both as an enabler and as a driver of new and improved communication satellites, is discussed. A brief look at the beginnings and evolution of satellite communications is given to reveal the continuing influence of technology over the past 25 years. An assessment of the current state of the art which serves as a benchmark representing how far technology has come and as a basis for comparison for future possibilities is presented. A short tutorial on communications satellite basics is presented, followed by an assessment of technologies used for satellite antennas and signal amplification and routing. A discussion of future service requirements follows, and emerging technologies are identified along with possible improved communications capabilities that can result from them. The outlook for the role of technology for future communication satellites is summarized.
CERN. Geneva; QEII Conference Centre
Sell to CERN, partner with CERN and learn about its pivotal role in European Grids and e-business This afternoon event will highlight the key areas of distributed computing and enterprise applications to Information and Communication Technology companies. The meeting will be held as a joint forum with First Tuesday Geneva, a networking organisation for business and investors in the Geneva region. The CERN Openlab for DataGrid applications is a means by which companies may partner with CERN to testbed their hardware and software products for Grid applications. Grid technology developed at CERN is already being used for particle physics and healthcare applications, making the laboratory an ideal site for collaborative development. British companies are already participating in this initiative and the opportunity is now available to medium-sized IT companies. In addition, a number of enterprise applications will be described. This software has been developed to manage the unique engineering and administrative ch...
Gillette-Guyonnet, Sophie; Secher, Marion; Vellas, Bruno
The prevention of dementias, such as Alzheimer's disease (AD), is a growing public health concern, due to a lack of effective curative treatment options and a rising global prevalence. Various potential risk or preventive factors have been suggested by epidemiological research, including modifiable lifestyle factors such as diet. Current epidemiological data are in favour of a protective role of certain micronutrients (B vitamins related to homocysteine metabolism, the anti-oxidant vitamins C and E, flavonoids, polyunsatured omega-3 fatty acids, vitamin D) and macronutrients (fish) in the prevention of cognitive decline and dementia/AD. Some factors have been targeted by interventions tested in randomized controlled trials (RCTs), but many of the results are conflicting with observational evidence. Epidemiological analysis of the relations between nutrient consumption and cognitive decline is complex and it is highly unlikely that a single component plays a major role. In addition, since multiple factors across the life course influence brain function in late life, multidomain interventions might be more promising in the prevention of cognitive decline and dementia/AD. Designing such trials remains very challenging for researchers. The main objective of this paper is to review the epidemiologic data linking potential protective factors to cognitive decline or dementia/AD, focusing particularly on the roles of adiposity, caloric restriction, micro (group B vitamins related to homocysteine metabolism, the anti-oxidant vitamins C and E, flavonoids, polyunsatured omega-3 fatty acids, vitamin D) and macronutrients (fish). Limitations of the current data, divergence with results of interventional prevention studies and challenges for future research are discussed.
Full Text Available Yousif E Himeidan Vector Control Unit, Africa Technical Research Centre, Vector Health International, Arusha, Tanzania Abstract: Rift Valley fever (RVF is a zoonotic, mosquito-borne viral disease that affects human health and causes significant losses in the livestock industry. Recent outbreaks have led to severe human infections with high mortality rates. There are many challenges to applying effective preventive and control measures, including weak infrastructure of health facilities, lack of capacity and support systems for field logistics and communication, access to global expert organizations, and insufficient information on the epidemiological and reservoir status of the RVF virus. The health systems in East African countries are underdeveloped, with gaps in adaptability to new, more accurate and rapid techniques, and well-trained staff that affect their capacity to monitor and evaluate the disease. Surveillance and response systems are inadequate in providing accurate information in a timely manner for decision making to deal with the scope of interrupting the disease transmission by applying mass animal vaccination, and other preventive measures at the early stage of an outbreak. The historical vaccines are unsuitable for use in newborn and gestating livestock, and the recent ones require a booster and annual revaccination. Future live-attenuated RVF vaccines should possess lower safety concerns regardless of the physiologic state of the animal, and provide rapid and long-term immunity after a single dose of vaccination. In the absence of an effective vaccination program, prevention and control measures must be immediately undertaken after an alert is generated. These measures include enforcing and adapting standard protocols for animal trade and movement, extensive vector control, safe disposal of infected animals, and modification of human–animal contact behavior. Directing control efforts on farmers and workers who deal with
Sadin, Stanley R.; Povinelli, Frederick P.; Rosen, Robert
As a result of the new Space Policy, the NASA technology program has been called upon to a provide a solid base of national capabilities and talent to serve NASA's civil space program, commercial, and other space sector interests. This paper describes the new technology program structure and its characteristics, traces its origin and evolution, and projects the likely near- and far-term strategic steps. It addresses the alternative 'push-pull' approaches to technology development, the readiness levels to which the technology needs to be developed for effective technology transfer, and the focused technology programs currently being implemented to satisfy the needs of future space systems.
Demonstration Program IVHM/ EHM MondaloyTM ALREST Combustion Stability Mid Term Implementation 3GRB Risk Reduction 3GRB Demo (Subscale) Far Term...the development of the next generation of rocket engine technology – Drive towards model driven development – Strong emphasis on Systems Engineering...Critical tech for high performance domestic ORSC liquid rocket engine – Program goals defined by DoD, NASA and industry partnership – Strong focus
Hafner, Armin; Banasiak, Krzysztof
Carbon Dioxide, CO2 (R744) was one of the first commonly applied working fluids in the infancy of refrigeration more than 100 years ago. In contrast to ammonia it mainly disappeared after the first generation of synthetic refrigerants have been introduced to the market after 1930. One reason was that the transition from low-rpm belt driven compressors towards the direct electrical motor driven compressors (50-60 Hz) was not performed for CO2 compressors before the revival introduced by Gustav Lorentzen in the 90is of last century. Since 1988 an enormous R & D effort has been made to further develop CO2 refrigeration technology in spite of the opposition from the chemical industry. Today CO2 refrigeration and heat pumping technologies are accepted as viable and sustainable alternatives for several applications like commercial refrigeration, transport refrigeration, vehicle air conditioning & heat pumping, domestic hot water heat pumps and industrial applications. For some applications, the current threshold to introduce R744 technology can be overcome when the system design takes into account the advantage of the thermo dynamical- and fluid properties of CO2. I.e. the system is designed for transcritical operation with all it pros and cons and takes into consideration how to minimize the losses, and to apply the normally lost expansion work. Shortcut-designs, i.e. drop in solutions, just replacing the H(C)FC refrigeration unit with an CO2 systems adapted for higher system pressures will not result in energy efficient products. CO2 systems do offer the advantage of enabling flooded evaporators supported with adapted ejector technology. These units offer high system performances at low temperature differences and show low temperature air mal-distributions across evaporators. This work gives an overview for the development possibilities for several applications during the next years. Resulting in a further market share increase of CO2 refrigeration and heat pump
Bulow, A. V.
Research and technology in Germany are discussed. The rapid transfer of scientific knowledge and techniques from the laboratory to the manufacturing and industrial communities is identified as a priority. It is recommended that the government give maximum support to the aviation and space flight industries.
Bonati, A.; Fusi, R.; Longoni, F.
The future space missions span over a wide range of scientific objectives. After different successful scientific missions, other international cornerstone experiments are planned to study of the evolution of the universe and of the primordial stellar systems, and our solar system. Space missions for the survey of the microwave cosmic background radiation, deep-field search in the near and mid-infrared region and planetary exploration will be carried out. Several fields are open for research and development in the space business. Three major categories can be found: detector technology in different areas, electronics, and software. At LABEN, a Finmeccanica Company, we are focusing the technologies to respond to this challenging scientific demands. Particle trackers based on silicon micro-strips supported by lightweight structures (CFRP) are studied. In the X-ray field, CCD's are investigated with pixels of very small size so as to increase the spatial resolution of the focal plane detectors. High-efficiency and higly miniaturized high-voltage power supplies are developed for detectors with an increasingly large number of phototubes. Material research is underway to study material properties at extreme temperatures. Low-temperature mechanical structures are designed for cryogenic ( 20 K) detectors in order to maintain the high precision in pointing the instrument. Miniaturization of front end electronics with low power consumption and high number of signal processing channels is investigated; silicon-based microchips (ASIC's) are designed and developed using state-of-the-art technology. Miniaturized instruments to investigate the planets surface using X-Ray and Gamma-Ray scattering techniques are developed. The data obtained from the detectors have to be processed, compressed, formatted and stored before their transmission to ground. These tasks open up additional strategic areas of development such as microprocessor-based electronics for high-speed and parallel data
Mishra, Sandhya; Keswani, Chetan; Abhilash, P. C.; Fraceto, Leonardo F.; Singh, Harikesh Bahadur
Nanotechnology representing a new frontier in modern agriculture is anticipated to become a major thrust in near future by offering potential applications. This integrating approach, i.e., agri-nanotechnology has great potential to cope with global challenges of food production/security, sustainability and climate change. However, despite the potential benefits of nanotechnology in agriculture so far, their relevance has not reached up to the field conditions. The elevating concerns about fate, transport, bioavailability, nanoparticles toxicity and inappropriateness of regulatory framework limit the complete acceptance and inclination to adopt nanotechnologies in agricultural sector. Moreover, the current research trends lack realistic approach that fail to attain comprehensive knowledge of risk assessment factors and further toxicity of nanoparticles toward agroecosystem components viz. plant, soil, soil microbiomes after their release into the environment. Hence in the present review we attempt to suggest certain key points to be addressed in the current and future agri-nanotechnology researches on the basis of recognized knowledge gaps with strong recommendation of incorporating biosynthesized nanoparticles to carry out analogous functions. In this perspective, the major points are as follows: (i) Mitigating risk assessment factors (responsible for fate, transport, behavior, bioavailability and toxicity) for alleviating the subsequent toxicity of nanoparticles. (ii) Optimizing permissible level of nanoparticles dose within the safety limits by performing dose dependent studies. (iii) Adopting realistic approach by designing the experiments in natural habitat and avoiding in vitro assays for accurate interpretation. (iv) Most importantly, translating environmental friendly and non-toxic biosynthesized nanoparticles from laboratory to field conditions for agricultural benefits. PMID:28421100
Augustine, Chad [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bain, Richard [National Renewable Energy Lab. (NREL), Golden, CO (United States); Chapman, Jamie [Texas Tech Univ., Lubbock, TX (United States); Denholm, Paul [National Renewable Energy Lab. (NREL), Golden, CO (United States); Drury, Easan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hall, Douglas G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lantz, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thresher, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sandor, Debra [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bishop, Norman A. [Knight Piesold, Denver, CO (United States); Brown, Stephen R. [HDR/DTA, Portland, ME (Untied States); Cada, Glenn F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Felker, Fort [National Renewable Energy Lab. (NREL), Golden, CO (United States); Fernandez, Steven J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Goodrich, Alan C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hagerman, George [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Heath, Garvin [National Renewable Energy Lab. (NREL), Golden, CO (United States); O' Neil, Sean [Ocean Renewable Energy Coalition, Portland, OR (United States); Paquette, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tegen, Suzanne [National Renewable Energy Lab. (NREL), Golden, CO (United States); Young, Katherine [National Renewable Energy Lab. (NREL), Golden, CO (United States)
The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a future through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/
Vavoula, Giasemi N.; Sharples, Mike
We describe the future technology workshop (FTW), a method whereby people with everyday knowledge or experience in a specific area of technology use (such as using digital cameras) envision and design the interactions between current and future technology and activity. Through a series of structured workshop sessions, participants collaborate to…
Shaneyfelt, M.R.; Dodd, P.E.; Draper, B.L.; Flores, R.S.
Challenges related to radiation hardening CMOS technologies with shallow-trench isolation are explored. Results show that trench hardening can be more difficult than simply replacing the trench isolation oxide with a hardened field oxide.
Friedman, Douglas C; Alper, Joe
"Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic...
Bergmann, Uwe; Corlett, John; Dierker, Steve; Falcone, Roger; Galayda, John; Gibson, Murray; Hastings, Jerry; Hettel, Bob; Hill, John; Hussain, Zahid; Kao, Chi-Chang; Kirz, a= Janos; Long, Gabrielle; McCurdy, Bill; Raubenheimer, Tor; Sannibale, Fernando; Seeman, John; Shen, Z.-X.; Shenoy, Gopal; Schoenlein, Bob; Shen, Qun; /Argonne /Brookhaven /LBL, Berkeley /SLAC, SSRL
Many of the important challenges facing humanity, including developing alternative sources of energy and improving health, are being addressed by advances that demand the improved understanding and control of matter. While the visualization, exploration, and manipulation of macroscopic matter have long been technological goals, scientific developments in the twentieth century have focused attention on understanding matter on the atomic scale through the underlying framework of quantum mechanics. Of special interest is matter that consists of natural or artificial nanoscale building blocks defined either by atomic structural arrangements or by electron or spin formations created by collective correlation effects (Figure 1.1). The essence of the challenge to the scientific community has been expressed in five grand challenges for directing matter and energy recently formulated by the Basic Energy Sciences Advisory Committee . These challenges focus on increasing our understanding of, and ultimately control of, matter at the level of atoms, electrons. and spins, as illustrated in Figure 1.1, and serve the entire range of science from advanced materials to life sciences. Meeting these challenges will require new tools that extend our reach into regions of higher spatial, temporal, and energy resolution. X-rays with energies above 10 keV offer capabilities extending beyond the nanoworld shown in Figure 1.1 due to their ability to penetrate into optically opaque or thick objects. This opens the door to combining atomic level information from scattering studies with 3D information on longer length scales from real space imaging with a resolution approaching 1 nm. The investigation of multiple length scales is important in hierarchical structures, providing knowledge about function of living organisms, the atomistic origin of materials failure, the optimization of industrial synthesis, or the working of devices. Since the fundamental interaction that holds matter
Examines past achievements and discusses the future impact that applied science and medical technology will have in combating disease and illness. Suggests that long-range planning and organization on a national scale are essential. (JR)
This position paper explores challenges and opportunities for eco-feedback technology. Drawing on two design cases, I discuss the importance of supporting active participation as well as the articulation of work in everyday practices to facilitate reduction of consumption.......This position paper explores challenges and opportunities for eco-feedback technology. Drawing on two design cases, I discuss the importance of supporting active participation as well as the articulation of work in everyday practices to facilitate reduction of consumption....
Full Text Available Pervaporation (PV has been considered as one of the most active and promising areas in membrane technologies in separating close boiling or azeotropic liquid mixtures, heat sensitive biomaterials, water or organics from its mixtures that are indispensable constituents for various important chemical and bio-separations. In the PV process, the membrane plays the most pivotal role and is of paramount importance in governing the overall efficiency. This article evaluates and collaborates the current research towards the development of next generation nanomaterials (NMs and embedded polymeric membranes with regard to its synthesis, fabrication and application strategies, challenges and future prospects.
Laskin, R. A.; Sirlin, S. W.
Pointing requirements for spaceborne scientific instruments are getting progressively more stringent. At the same time the instruments are likely to fly in an increasingly disturbance rich environment characterized by large basebody and instrument to instrument dynamic interactions. It is not clear that current state-of-the-art pointing technology will be able to adequately address the needs of the mid 1990's. Design options to meet these needs are suggested herein including an innovative 'softmount' concept. The advantages of the softmount approach as compared to the traditional gimbal architecture are illustrated through a planar stability and disturbance response analysis.
Kling, Heather M; Nau, Gerard J; Ross, Ted M; Evans, Thomas G; Chakraborty, Krishnendu; Empey, Kerry M; Flynn, JoAnne L
Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The "Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy" session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials.
Brown, M; Sharples, S; Harding, J; Parker, C J; Bearman, N; Maguire, M; Forrest, D; Haklay, M; Jackson, M
The use of Geographic Information or GI, has grown rapidly in recent years. Previous research has identified the importance of usability and user centred design in enabling the proliferation and exploitation of GI. However, the design and development of usable GI is not simply a matter of applying the tried and tested usability methods that have been developed for software and web design. Dealing with data and specifically GI brings with it a number of issues that change the way usability and user centred design can be applied. This paper describes the outcomes of a workshop held in March 2010 exploring the core issues relating to GI usability. The workshop brought together an international group of twenty experts in both human factors and GI, from a wide range of academic and industrial backgrounds. These experts considered three key issues, the stakeholders in GI, key challenges applying usability to GI and the usability methods that can be successfully applied to GI. The result of this workshop was to identify some areas for future research, such as the production of meaningful metadata and the implications of blurring of the line between data producers and data consumers.
Shearer, Cameron J; Cherevan, Alexey; Eder, Dominik
Hybridizing nanocarbons, such as carbon nanotubes (CNTs) or graphene, with an active material is a powerful strategy towards designing next-generation functional materials for environmental and sustainable energy applications. While research on nanocomposites, created by dispersing the nanocarbon into polymer or ceramic matrices, began almost immediately after the popularization of CNTs and graphene in 1991 and 2004, respectively, nanocarbon hybrids are a relatively recent addition to the family of composite materials. In contrast to nanocomposites, which typically combine the intrinsic properties of both compounds, nanocarbon hybrids additionally provide access to both a large surface area required for gas/liquid-solid interactions and an extended interface, through which charge and energy transfer processes create synergistic effects that result in unique properties and superior performance. This progress report looks at the history of research on nanocarbons (fullerenes, CNTs and graphene) and their composites and hybrids, presents the origin of synergistic effects, reviews the most intriguing results on nanocarbon hybrid performance in heterogeneous catalysis, electrocatalysis, photocatalysis, batteries, supercapacitors, photovoltaics and sensors, and discusses remaining challenges and future research directions.
April H Wardhana
Full Text Available Scabies is a contagious skin disease caused by a mite of Sarcoptes scabiei . It is found worldwide particularly in regions related with of poverty, remote area, poor sanitations and nutritional status in both human and animals . Scabies is transmitted by direct contact . The clinical signs are intensive pruritis or itchiness, erythrema, papula and vesicle . Infestation S. scabiei caused damage skin and raised animal death (50 - 100% while 300 millions people per year were reported to suffer from scabies . Diagnosis of scabies is based on clinical signs and confirmed with gently scrapping the skin off burrow (seeking for eggs, faecals and mites . Beside that, the diagnosis can be obtained by ink test, mineral oil or fluorescence tetracycline test . ELISA method for detecting human scabies still has a disadvantage because there is a cross-reaction between host skin and var . S. scabiei antigens . The development of scabies vaccine also has many problems . Some human scabies cases were suspected from their livestock or pet animals . It is required a good and synergic collaboration between both health and livestock agencies that involved both human and vet medicals, investigators, quarantine staffs including researchers. Those factors become a challenge at present and in the future to prevent the spreading of scabies to a larger area and to minimize scabies cases in both human and animal, particularly in the endemic area .
Kosov, V. F.; Kuzmina, J. S.; Sytchev, G. A.; Zaichenko, V. M.
Since the active exploitation and usage of classical non-renewable energy resources the most promising direction is the development of technologies of heat and electricity production from renewable sources—biomass. This is important in terms of reducing the harmful man-made influence of fuel-and-energy sector on the ecological balance. One of the most important aims when using biomass is its pre-treatment. The paper describes the fuel preliminary preparation for combustion with such technological process as torrefaction. Torrefaction allows bringing the biomass fuel as close as it possible to fossil coals for the main thermotechnical parameters. During torrefaction moisture is removed from initial material and the partial thermal decomposition of its components appears. The final torrefied product can be recommended for utilization in existing coal-fired boilers without their major reconstruction. Thus torrefaction technology enables the partial or complete replacement of fossil coal. At JIHT RAS, a torrefaction pilot plant is developed. As heat transfer medium the gas-piston engine exhaust gases were used. Results of researching and proposals for further development are showed in this paper.
Sponsored by the U.S. Department of Defense © 2006 by Carnegie Mellon University 1 Pittsburgh, PA 15213-3890 Future Trends of Software Technology ...COVERED 00-00-2006 to 00-00-2006 4. TITLE AND SUBTITLE Future Trends of Software Technology and Applications: Software Architecture 5a. CONTRACT...and Applications: Software Architecture Paul Clements Software Engineering Institute Carnegie Mellon University Report Documentation Page Form
Venkatapathy, Ethiraj; Beck, Robin; Ellerby, Don; Feldman, Jay; Gage, Peter; Munk, Michelle; Wercinski, Paul
Realization within the US and NASA that future exploration both Human and Robotic will require innovative new technologies led to the creation of the Space Technology Mission Directorate and investment in game changing technologies with high pay-off. Some of these investments will see success and others, due to many of the constraints, will not attain their goal. The co-authors of this proposed presentation have been involved from concept to mission infusion aspects of entry technologies that are game changing. The four example technologies used to describe the challenges experienced along the pathways to success are at different levels of maturity. They are Conformal, 3-D MAT, HEEET and ADEPT. The four examples in many ways capture broad aspects of the challenges of maturation and illustrate what led some to be exceptionally successful and how others had to be altered in order remain viable game changing technologies.
Egger, Haakan; Greaker, Mads; Potter, Emily
Current state-of-the-art knowledge concludes that green house gas (GHG) emissions must be controlled and reduced within the next 30-40 years. The transport sector contributes almost a fifth of the current global emissions, and its share is likely to increase in the future. The US and a number of European countries have therefore introduced various support schemes for research and development (RandD) of low emission fuels that can potentially replace the current fossil fuels. One such alternative is biofuels. The advantage of biofuels are that it is easy to introduce into the transport sector. On the other hand, recent research papers question whether the supply of feedstock is sufficient, and to what extent biofuels lead to GHG emission reductions. This report reviews the current status of second generation biofuels. Second generation biofuels are made from cellulose, which according to our survey of the literature, is in more abundant supply than the first generation biofuels feedstocks. Furthermore, it seems to have the potential to reduce GHG emissions from the transport sector without leading to devastating land use changes, which recent critique has held against first generation biofuels. Given that governments have decided to support RandD of low emission fuels, we ask the following questions: Should second generation biofuels receive RandD support to the same extent as other low emission fuels like hydrogen? How should support schemes for second generation biofuels be designed? Second generation biofuels can be divided according to the production process into thermo-chemical and bio-chemical. With respect to the thermo-chemical process the potential for cost reductions seems to be low. On the other hand, ethanol made from cellulose using the biochemical conversion process is far from a ripe technology. Expert reports point to several potential technological breakthroughs which may reduce costs substantially. Hence, cellulosic ethanol, should receive direct
This Special Issue of Bioresource Technology is dedicated to selected contributions presented at the international Workshop: “Livestock waste treatment systems of the future: A challenge to environmental quality, food safety, and sustainability,” held 2-4 April, 2008, in Florence, South Carolina (US...
McGowan, Kevin B; Stiegman, Glenn
In the United States, few Food and Drug Administration (FDA)-approved options exist for the treatment of focal cartilage and osteochondral lesions. Developers of products for cartilage repair face many challenges to obtain marketing approval from the FDA. The objective of this review is to discuss the necessary steps for FDA application and approval for a new cartilage repair product. FDA Guidance Documents, FDA Panel Meetings, scientific organization recommendations, and clinicaltrials.gov were reviewed to demonstrate the current thinking of FDA and the scientific community on the regulatory process for cartilage repair therapies. Cartilage repair therapies can receive market approval from FDA as medical devices, drugs, or biologics, and the specific classification of product can affect the nonclinical, clinical, and regulatory strategy to bring the product to market. Recent FDA guidance gives an outline of the required elements to bring a cartilage repair product to market, although these standards are often very general. As a result, companies have to carefully craft their study patient population, comparator group, and clinical endpoint to best showcase their product's attributes. In addition, regulatory strategy and manufacturing process validation need to be considered early in the clinical study process to allow for timely product approval following the completion of clinical study. Although the path to regulatory approval for a cartilage repair therapy is challenging and time-consuming, proper clinical trial planning and attention to the details can eventually save companies time and money by bringing a product to the market in the most expeditious process possible.
Lech Wosinski; Liu Liu; Ning Zhu; Lars Thylen
A short overview of integrated waveguide demultiplexers for different applications in future highly inte- grated optical communication systems is presented. Some fabricated devices based on amorphous silicon nanowire technology are described.
Thermoelectricity is a general term for a number of effects describing the direct interconversion of heat and electricity. Thermoelectric devices are therefore promising, environmental-friendly alternatives to conventional power generators or cooling units. Since the mid-90s, research on thermoelectric properties and their applications has steadily increased. In the course of years, the development of high-temperature resistant TE materials and devices has emerged as one of the main areas of interest focusing both on basic research and practical applications. A wide range of innovative and cost-efficient material classes has been studied and their properties improved. This has also led to advances in synthesis and metrology. The paper starts out with thermoelectric history, basic effects underlying thermoelectric conversion and selected examples of application. The main part focuses on thermoelectric materials including an outline of the design rules, a review on the most common materials and the feasibility of improved future high-temperature thermoelectric converters.
Barletta, W A; Corlett, J N; Emma, P; Huang, Z; Kim, K -J; Lindberg, R; Murphy, J B; Neil, G P; Nguyen, D C; Pellegrini, C; Rimmer, R A; Sannibale, F; Stupakov, G; Walker, R P
With the scientific successes of the soft X-ray FLASH facility in Germany and the recent spectacular commissioning of the Linac Coherent Light Source at SLAC, free electron lasers are poised to take center stage as the premier source of tunable, intense, coherent photons of either ultra-short time resolution or ultra-fine spectral resolution, from the far infrared to the hard X-ray regime. This paper examines the state of the art in FEL performance and the underlying enabling technologies. It evaluates the state of readiness of the three basic machine architectures—SASE FELs, seeded FELs, and FEL oscillators—for the major X-ray science user facilities on the 5–10 years time scale and examines the challenges that lie ahead for FELs to achieve their full potential throughout the entire spectral range. In soft and hard X-rays, high longitudinal coherence, in addition to full transverse coherence, will be the key performance upgrade; ideas using laser-based or self-seeding or oscillators can be expected to be qualitatively superior to today's SASE sources. Short pulses, from femtoseconds to attoseconds, can be realistically envisioned. With high repetition rate electron sources coupled to superconducting radiofrequency linear accelerators, unprecedented average beam brightness will be possible and many users would be served simultaneously by a single accelerator complex.
Barletta, W.A. [Department of Physics, Massachusetts Institute of Technology, Bldg. 26-563, 77 Massachusetts Avenue, Cambridge, MA 02139-4307 (United States); Bisognano, J. [Synchrotron Radiation Center, 3731 Schneider Dr., Stoughton, WI 53589-3097 (United States); Corlett, J.N. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Emma, P.; Huang, Z. [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Kim, K.-J.; Lindberg, R. [Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439 (United States); Murphy, J.B., E-mail: email@example.com [National Synchrotron Light Source, Building 725C, Upton, NY 11973 (United States); Neil, G.R. [Thomas Jefferson National Accelerator Laboratory, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Nguyen, D.C. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States); Pellegrini, C. [Department of Physics and Astronomy, University of California-Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095 (United States); Rimmer, R.A. [Thomas Jefferson National Accelerator Laboratory, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Sannibale, F. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Stupakov, G. [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Walker, R.P. [Diamond Light Source Ltd, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); Zholents, A.A. [Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439 (United States)
With the scientific successes of the soft X-ray FLASH facility in Germany and the recent spectacular commissioning of the Linac Coherent Light Source at SLAC, free electron lasers are poised to take center stage as the premier source of tunable, intense, coherent photons of either ultra-short time resolution or ultra-fine spectral resolution, from the far infrared to the hard X-ray regime. This paper examines the state of the art in FEL performance and the underlying enabling technologies. It evaluates the state of readiness of the three basic machine architectures-SASE FELs, seeded FELs, and FEL oscillators-for the major X-ray science user facilities on the 5-10 years time scale and examines the challenges that lie ahead for FELs to achieve their full potential throughout the entire spectral range. In soft and hard X-rays, high longitudinal coherence, in addition to full transverse coherence, will be the key performance upgrade; ideas using laser-based or self-seeding or oscillators can be expected to be qualitatively superior to today's SASE sources. Short pulses, from femtoseconds to attoseconds, can be realistically envisioned. With high repetition rate electron sources coupled to superconducting radiofrequency linear accelerators, unprecedented average beam brightness will be possible and many users would be served simultaneously by a single accelerator complex.
Burden, Kevin; Aubusson, Peter; Brindley, Sue; Schuck, Sandy
Recent research in teacher education futures has identified two themes that require further study: the changing nature of knowledge and the changing capabilities of technologies. This article examines the intersection of these two themes and their implications for teacher education. The research employed futures methodologies based on scenario…
Norton, Charles D.; Moe, Karen
This paper examines the Earth science decadal survey era and the role ESTO developed sensor web technologies can contribute to the scientific observations. This includes hardware and software technology advances for in-situ and in-space measurements. Also discussed are emerging areas of importance such as the potential of small satellites for sensor web based observations as well as advances in data fusion critical to the science and societal benefits of future missions, and the challenges ahead.
Fang, Xi; Xue, Guoliang
Smart grid, regarded as the next generation power grid, uses two-way flows of electricity and information to create a widely distributed automated energy delivery network. In this work we present our vision on smart grid from the perspective of wireless communications and networking technologies. We present wireless communication and networking paradigms for four typical scenarios in the future smart grid and also point out the research challenges of the wireless communication and networking technologies used in smart grid
Kim, Daniel; Jeong, Hawoong; Youn, Hyejin
We consider inventions as novel combinations of existing technological capabilities. Patent data allow us to explicitly identify such combinatorial processes in invention activities. Unconsidered in the previous research, not every new combination is novel to the same extent. Some combinations are naturally anticipated based on patent activities in the past or mere random choices, and some appear to deviate exceptionally from existing invention pathways. We calculate a likelihood that each pair of classification codes is put together at random, and a deviation from the empirical observation so as to assess its overall novelty (or conventionality) the patent brings forth at each year. An invention is considered as unconventional if a pair of codes therein is unlikely to be used together given the statistics in the past. Temporal evolution of the distribution indicates the patenting activities become more being established with occasional cross-over combinations. Our analyses show that patents introducing novel...
Batra, Padma; Tomar, Reena; Kapoor, Rajiv
It is known that diabetes is a very serious disease as it may lead to heart attack, kidney failure and neuro diseases. The present study was aimed to review and compare various techniques useful for detecting diabetes or hypoglycemia in human body. In this paper we discuss the invasive and non-invasive techniques which are used for early detection of hypoglycemia or hyperglycemia and highlight their advantages as well as limitations. The use of bio impedance measurement technology has been described as it is an emerging non-invasive technique useful for the same purpose.
Aguey-Zinsou, Kondo-Francois; Wang, Da-Wei; Su, Dang-Sheng
Special Issue: The Future of Energy. The science and engineering of clean energy now is becoming a multidisciplinary area, typically when new materials, chemistry, or mechanisms are met. "Trial and error" is the past. Exploration of new concepts for future clean energy can be accomplished through computer-aided materials design and reaction simulation, thanks to innovations in information technologies. This special issue, a fruit of the Energy Future Conference organized by UNSW Australia, has compiled some excellent examples of such approaches.
Tong, Michael Xiaoliang; Hansen, Alana; Hanson-Easey, Scott; Cameron, Scott; Xiang, Jianjun; Liu, Qiyong; Sun, Yehuan; Weinstein, Philip; Han, Gil-Soo; Williams, Craig; Bi, Peng
China is one of the largest countries in the world with nearly 20% of the world's population. There have been significant improvements in economy, education and technology over the last three decades. Due to substantial investments from all levels of government, the public health system in China has been improved since the 2003 severe acute respiratory syndrome (SARS) outbreak. However, infectious diseases still remain a major population health issue and this may be exacerbated by rapid urbanization and unprecedented impacts of climate change. This commentary aims to explore China's current capacity to manage infectious diseases which impair population health. It discusses the existing disease surveillance system and underscores the critical importance of strengthening the system. It also explores how the growing migrant population, dramatic changes in the natural landscape following rapid urbanization, and changing climatic conditions can contribute to the emergence and re-emergence of infectious disease. Continuing research on infectious diseases, urbanization and climate change may inform the country's capacity to deal with emerging and re-emerging infectious diseases in the future.
John B. Troy
Full Text Available Visual prostheses are now entering the clinical marketplace. Such prostheses were originally targeted for patients suffering from blindness through retinitis pigmentosa (RP. However, in late July of this year, for the first time a patient was given a retinal implant in order to treat dry age-related macular degeneration. Retinal implants are suitable solutions for diseases that attack photoreceptors but spare most of the remaining retinal neurons. For eye diseases that result in loss of retinal output, implants that interface with more central structures in the visual system are needed. The standard site for central visual prostheses under development is the visual cortex. This perspective discusses the technical and socioeconomic challenges faced by visual prostheses.
Hart, Russ A.; Parker, Roger
Designing a distance learning classroom requires integration of educational goals and philosophy with technology and ergonomics. The technological challenge and key to designing effective distance learning and multimedia classrooms is creating an environment in which the participants--students, and teacher--may easily interact with instructional…
Millar-Schijf, Carla C.J.M.; Lockett, Martin
This paper analyses demographic and organisational trends associated with an ageing workforce and introduces the articles in the special issue of Technological Forecasting and Social Change on Ageing2Agility: Multi-stakeholder Technological Forecasting for the Multi-generational Challenges in the
Eaton, Weston; Wright, Wynne; Whyte, Kyle; Gasteyer, Stephen P.; Gehrke, Pat J.
Universities' increasing applications of science and technology to address a wide array of societal problems may serve to thwart democratic engagement strategies. For emerging technologies, such challenges are particularly salient, as knowledge is incomplete and application and impact are uncertain or contested. Insights from science and…
Lee, Lung-Sheng Steven
The technology education in Taiwan is prescribed in the national curriculum and provided to all students in grades 1-12. However, it faces the following challenges: (1) Lack of worthy image, (2) Inadequate teachers in elementary schools, (3) Deficient teaching vitality in secondary schools, and (4) Diluted technology teacher education programs. In…
Rusu, S.; Sachdev, M.; Svensson, C.; Nauta, Bram
Summary form only given. Moore's Law drives VLSI technology to continuous increases in transistor densities and higher clock frequencies. This tutorial will review the trends in VLSI technology scaling in the last few years and discuss the challenges facing process and circuit engineers in the 100nm
Lee, Jieun; Husman, Jenefer; Scott, Kimberly A.; Eggum-Wilkens, Natalie D.
The COMPUGIRLS: Culturally relevant technology program for adolescent girls was developed to promote underrepresented girls' future possible selves and career pathways in computer-related technology fields. We hypothesized that the COMPUGIRLS would promote academic possible selves and self-regulation to achieve these possible selves. We compared…
Lee, Jieun; Husman, Jenefer; Scott, Kimberly A.; Eggum-Wilkens, Natalie D.
The COMPUGIRLS: Culturally relevant technology program for adolescent girls was developed to promote underrepresented girls' future possible selves and career pathways in computer-related technology fields. We hypothesized that the COMPUGIRLS would promote academic possible selves and self-regulation to achieve these possible selves. We compared…
This article discusses the future of wayfinding technologies for individuals with visual impairments and the need for environmental literacy. It describes smart computer chips that can be embedded into the environment, robots that can assist individuals with disabilities, and GPS wheelchairs. Recommendations for advancing these technologies are…
Easterbrook, Philippa; Johnson, Cheryl; Figueroa, Carmen; Baggaley, Rachel
HIV infection and viral hepatitis due to HBV and HCV infection are major causes of chronic disease worldwide, and share some common routes of transmission, epidemiology, initial barriers faced in treatment access, and in strategies for a global public health response. Testing and diagnosis of HIV, HBV, and HCV infection is the gateway for access to both care and treatment and prevention services, and crucial for an effective HIV and hepatitis epidemic response. In this review article, we first summarize the common goals and guiding principles in a public health approach to HIV and hepatitis testing. We summarize the impressive global progress in HIV testing scale-up and evolution of approaches, with expansion of provider-initiated testing and counseling in clinical settings (particularly antenatal and tuberculosis clinics), the introduction of more community based testing services, and use of rapid diagnostic tests enabling provision of same-day test results. However, 46% of all people living with HIV are still unaware of their serostatus, and many continue to be diagnosed and start antiretroviral therapy late. As testing and treatment scale-up accelerates for an "treat all" approach, other challenges to address include how to better focus testing and reach those yet undiagnosed and most at risk, especially key populations, men, adolescents, and children. We summarize future directions in HIV testing to speed scale-up and close gaps that are addressed in the WHO 2015 consolidated HIV testing guidelines. In contrast to HIV, action in hepatitis testing and treatment has been fragmented and limited to a few countries, and there remains a large burden of undiagnosed cases globally. We summarize key challenges in the hepatitis testing response, including lack of simple, reliable, and low-cost diagnostic tests, laboratory capacity, and testing facilities; inadequate data to guide country specific hepatitis testing approaches and who to screen; stigmatization and social
Geiger, James D; Hirschl, Ronald B
The pace of medical innovation continues to increase. The deployment of new technologies in surgery creates many ethical challenges including how to determine safety of the technology, what is the timing and process for deployment of a new technology, how are patients informed before undergoing a new technology or technique, how are the outcomes of a new technology evaluated and how are the responsibilities of individual patients and society at large balanced. Ethical considerations relevant to the implementation of ECMO and robotic surgery are explored to further discussion of how we can optimize the delicate balance between innovation and regulation.
Ryan, J. G.; Eriksson, S. C.
Inspired by the recommendations of the NSF report “Fostering Learning in the Networked World: The Cyberlearning Opportunity and Challenge” (NSF08204), the NSF National STEM Digital Learning program funded “Planning for the Future of Geocybereducation” Workshop sought to bring together leaders from the geoscience education community, from major geoscience research initiatives, and from the growing public- and private-sector geoscience information community. The objectives of the workshop were to begin conversations aimed at identifying best practices and tools for geoscience cyber-education, in the context of both the changing nature of learners and of rapidly evolving geo-information platforms, and to provide guidance to the NSF as to necessary future directions and needs for funding. 65 participants met and interacted live for the two-day workshop, with ongoing post-meeting virtual interactions via a collaborative workspace (www.geocybered.ning.com). Topics addressed included the rapidly changing character of learners, the growing capabilities of geoscience information systems and their affiliated tools, and effective models for collaboration among educators, researchers and geoinformation specialists. Discussions at the meeting focused on the implications of changing learners on the educational process, the challenges for teachers and administrators in keeping pace, and on the challenges of communication among these divergent professional communities. Ongoing virtual discussions and collaborations have produced a draft workshop document, and the workshop conveners are maintaining the workshop site as a venue for ongoing discussion and interaction. Several key challenges were evident from the workshop discussions and subsequent interactions: a) the development of most of the large geoinformatics and geoscience research efforts were not pursued with education as a significant objective, resulting in limited financial support for such activities after the
Anderberg, Leif; Aldskogius, Håkan; Holtz, Anders
The history of spinal cord injuries starts with the ancient Egyptian medical papyrus known as the Edwin Smith Surgical Papyrus. The papyrus written about 2500 B.C.by the physician and architect of the Sakkara pyramids Imhotep, describes "crushed vertebra in his neck" as well as symptoms of neurological deterioration. An ailment not to be treated was the massage to the patients at that time. This fatalistic attitude remained until the end of World War II when the first rehabilitation centre focused on the rehabilitation of spinal cord injured patients was opened. Our knowledge of the pathophysiological processes, both the primary as well as the secondary, has increased tremendously. However, all this knowledge has only led to improved medical care but not to any therapeutic method to restore, even partially, the neurological function. Neuroprotection is defined as measures to counteract secondary injury mechanisms and/or limit the extent of damage caused by self-destructive cellular and tissue processes. The co-existence of several distinctly different injury mechanisms after trauma has provided opportunities to explore a large number of potentially neuroprotective agents in animal experiments such as methylprednisolone sodium succinate. The results of this research have been very discouraging and pharmacological neuroprotection for patients with spinal cord injury has fallen short of the expectations created by the extensive research and promising observations in animal experiments. The focus of research has now, instead, been transformed to the field of neural regeneration. This field includes the discovery of regenerating obstacles in the nerve cell and/or environmental factors but also various regeneration strategies such as bridging the gap at the site of injury as well as transplantation of foetal tissue and stem cells. The purpose of this review is to highlight selected experimental and clinical studies that form the basis for undertaking future challenges in
Karpicke, Jeffrey D.
Recent advances in the cognitive science of learning have important implications for instructional practices at all levels of education. Educational technology is becoming pervasive, yet very little of it is designed around principles of learning from cognitive science. This talk discusses current trends in educational technologies, including personalized online learning systems and MOOCs, and how new advanced learning technologies will impact education in the future.
Luxton, David D; June, Jennifer D; Kinn, Julie T
This review reports on current and emerging technologies for suicide prevention. Technology-based programs discussed include interactive educational and social networking Web sites, e-mail outreach, and programs that use mobile devices and texting. We describe innovative applications such as virtual worlds, gaming, and text analysis that are currently being developed and applied to suicide prevention and outreach programs. We also discuss the benefits and limitations of technology-based applications and discuss future directions for their use.
Full Text Available Simulator based training has its own unique features and problems associated with it. There is a need to discuss these issues in order to understand the real meaning of simulator based training and to handle it effectively. Like other fields of training, use of simulation in the maritime industry is owing to the multiple factors covering technological, financial and training needs of the time. When properly used, supported by well trained and experienced instructors, simulator training, through its risk free environment, can contribute to a reduction in accidents and improve capability and efficiency, by providing trainees with the necessary experience and self confidence to carry out their roles, functions and tasks.
Full Text Available The growth of the Internet, mobile phones, social media and other digital technologies has changed our world in many ways. It has provided individuals with information that was previously only available to a select few. An example of the reach of technology is data that as of October 2012, there are over 6 billion phones worldwide (BBC, 2012. The availability of data in real time has presented hopes of intervening more efficiently and managing health problems by leveraging limited human resources. It also has an impact in changing the roles of providers and patients and in legal and ethical issues including privacy in digital health interactions. This paper will discuss why digital technology has received recent attention in the area of mental health, present some applications of technology for mental health to date, explore the challenges to full implementation in clinical settings, and present future opportunities for digital technologies.El crecimiento del Internet, los teléfonos móviles, las redes sociales y otras tecnologías digitales ha cambiado nuestro mundo de muchas maneras. Ha proporcionado a las personas con la información que antes sólo estaba disponible para un grupo selecto, por ejemplo a partir de octubre de 2012. Un ejemplo del alcance de la tecnología son los datos que dicen que hay más de 6 millones de teléfonos en todo el mundo (BBC, 2012. La disponibilidad de los datos en tiempo real a presentado la esperanza de intervenir de manera más eficiente y manejar los problemas de salud los recursos humanos limitados. También tiene un impacto en el cambio de los roles de los proveedores y los pacientes y en aspectos legales y éticos, incluyendo la privacidad en las interacciones de salud digital. Este artículo discutirá unas razones por cual la tecnología digital ha recibido atención recientemente en el área de salud mental, presentará algunas aplicaciones de la tecnología para mejorar la salud mental hasta la fecha
Marini, A. E.; Racca, G. D.; Foing, B. H.
SMART-1 is the first ESA Small Mission for Advanced Research in Technology, with the prime objective of demonstrating the use of Solar Electric Primary Propulsion in a planetary mission. Further to this, SMART-1 will test novel spacecraft technologies and will host six instruments carrying out nine technology and science experiments, all aimed at preparing future ESA Cornerstones, including the ESA Mercury Cornerstone (now named BepiColombo) and other future planetary missions under study, as well as solar and fundamental physics missions.
Vakil, Eli; Hoofien, Dan
This is an invited paper for a special issue on international perspectives on training and practice in clinical neuropsychology. We provide a review of the status of clinical neuropsychology in Israel, including the history of neuropsychological, educational, and accreditation requirements to become a clinical neuropsychologist and to practice clinical neuropsychology. The information is based primarily on the personal knowledge of the authors who have been practicing clinical neuropsychology for over three decades and hold various administrative and academic positions in this field. Second, we conducted three ad hoc surveys among clinical and rehabilitation psychologists; heads of academic programs for rehabilitation and neuropsychology; and heads of accredited service providers. Third, we present a literature review of publications by clinical neuropsychologists in Israel. Most of the clinical neuropsychologists are graduates of either rehabilitation or clinical training programs. The vast majority of neuropsychologists are affiliated with rehabilitation psychology. The training programs (2-3 years of graduate school) provide solid therapeutic and diagnostic skills to the students. Seventy-five percent of the participants in this survey are employed at least part-time by public or state-funded institutions. Israeli neuropsychologists are heavily involved in case management, including vocational counseling, and rehabilitation psychotherapy. Conclusions and future goals: Although clinical neuropsychologists in Israel are well educated and valued by all health professionals, there are still several challenges that must be addressed in order to further advance the field and the profession. These included the need for Hebrew-language standardized and normalized neuropsychological tests and the application of evidence-based interventions in neuropsychological rehabilitation.
Industrialization that Latin America has experienced during the past 50 years, the increase of population and the growth of chemical-related industries has generated a variety of environmental problems that must be addressed. After assessing these profound changes, greater emphasis should be placed on the study of environmental health and toxicology. Latin American countries face many problems that are common to other developing nations. Therefore, there is a demand for safety assessment and regulatory control of chemicals that create a need for increasing numbers of toxicologists. To meet this demand, educational programs in toxicology have to be designed. This paper utilizes a consultation questionnaire that includes toxicology-network members, scientists and educational institutions where toxicology is taught. An analysis of the information collected is made, with an emphasis on what we currently lack and on future challenges for toxicology professionals. Although the response from the study institutions was 65% (13 countries out of 20), the paper aims to assess the present situation of toxicology. The convenience for a certification/recognition for toxicologists is also evaluated. Action needs to be taken to promote scientific development based on regional specific needs that require increasing at the number of toxicology programs, and promoting of cooperation between academics and researchers. Among the limitations we have are the variability of curricula, objectives and priorities. The increasing globalization of markets and regulations requires the harmonization of graduate/postgraduate programs to ensure that risk assessment and management are dealt with uniformly. Cooperation among our countries and international assistance should play a more prominent role in the promotion of regional integration and the more efficient utilization of international experience in defining educational policies.
Viruses cause epidemics on all major cultures of agronomic importance, representing a serious threat to global food security. As strict intracellular pathogens, they cannot be controlled chemically and prophylactic measures consist mainly in the destruction of infected plants and excessive pesticide applications to limit the population of vector organisms. A powerful alternative frequently employed in agriculture relies on the use of crop genetic resistances, approach that depends on mechanisms governing plant-virus interactions. Hence, knowledge related to the molecular bases of viral infections and crop resistances is key to face viral attacks in fields. Over the past 80 years, great advances have been made on our understanding of plant immunity against viruses. Although most of the known natural resistance genes have long been dominant R genes (encoding NBS-LRR proteins), a vast number of crop recessive resistance genes were cloned in the last decade, emphasizing another evolutive strategy to block viruses. In addition, the discovery of RNA interference pathways highlighted a very efficient antiviral system targeting the infectious agent at the nucleic acid level. Insidiously, plant viruses evolve and often acquire the ability to overcome the resistances employed by breeders. The development of efficient and durable resistances able to withstand the extreme genetic plasticity of viruses therefore represents a major challenge for the coming years. This review aims at describing some of the most devastating diseases caused by viruses on crops and summarizes current knowledge about plant-virus interactions, focusing on resistance mechanisms that prevent or limit viral infection in plants. In addition, I will discuss the current outcomes of the actions employed to control viral diseases in fields and the future investigations that need to be undertaken to develop sustainable broad-spectrum crop resistances against viruses.
Full Text Available Parunyou Julayanont,1 Amputch Karukote,2 Doungporn Ruthirago,1 Deepa Panikkath,3 Ragesh Panikkath3 1Department of Neurology, Texas Tech University Health Science Center, Lubbock, TX, USA; 2Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA Abstract: Idiopathic intracranial hypertension (IIH is an uncommon disorder characterized by increased intracranial pressure without radiological or laboratory evidence of intracranial pathology except empty sella turcica, optic nerve sheath with filled out cerebrospinal fluid spaces, and smooth-walled nonflow-related venous sinus stenosis or collapse. This condition typically affects obese women. The incidence of IIH is increasing with the rising prevalence of obesity. Persistent headache is the most common symptom. Visual impairment is a serious complication that may not be recognized by the patients. This paper reviews clinical manifestations, diagnostic challenges, and current treatments of IIH in adults. Various imaging modalities have been studied on their validity for detection of IIH and papilledema. This review also includes new studies on medical, surgical, and interventional management of this condition. Acetazolamide and topiramate are the only two medications that have been studied in randomized controlled trials about their efficacy in treatment of IIH. In patients who have severe visual impairment or progressive visual deterioration despite medical management, surgical or interventional treatment may be considered. The efficacy and complications of cerebrospinal fluid diversion, optic nerve sheath fenestration, and endovascular venous stenting reported in the last 3 decades have been summarized in this review. Finally, the prospective aspects of biomarkers and treatments are proposed for future research. Keywords: acetazolamide, cerebrospinal fluid shunts, endovascular
In contrast to subjects such as mathematics and the sciences, it has been argued that technology education lacks a clear definition and a clearly defined knowledge base. This discursive article seeks to inform the debate by highlighting the matter of subject definition and in addition to examine the key issue of the knowledge which underpins…
Sitruk-Ware, Regine; Nath, Anita; Mishell, Daniel R.
Steady progress in contraception research has been achieved over the past 50 years. Hormonal and non-hormonal modern contraceptives have improved women’s lives by reducing different health conditions that contributed to considerable morbidity. However the contraceptives available today are not suitable to all users and the need to expand contraceptive choices still exists. Novel products such as new implants, contraceptive vaginal rings, transdermal patches and newer combinations of oral contraceptives have recently been introduced in family planning programs and hormonal contraception is widely used for spacing and limiting births. Concerns over the adverse effects of hormonal contraceptives have led to research and development of new combinations with improved metabolic profile. Recent developments include use of natural compounds such as estradiol (E2) and estradiol valerate (E2V) with the hope to decrease thrombotic risk, in combination with newer progestins derived from the progesterone structure or from spirolactone, in order to avoid the androgenic effects. Progesterone antagonists and progesterone receptor modulators are highly effective in blocking ovulation and preventing follicular rupture and are undergoing investigations in the form of oral pills and in semi long-acting delivery systems. Future developments also include the combination of a contraceptive with an antiretroviral agent for dual contraception and protection against sexually transmitted diseases, to be used before intercourse or on demand, as well as for continuous use in dual-protection rings. Alhough clinical trials of male contraception have reflected promising results, limited involvement of industry in that area of research has decreased the likelihood of having a male method available in the current decade. Development of non-hormonal methods are still at an early stage of research, with the identification of specific targets within the reproductive system in ovaries and testes, as
Although chemicals have been reportedly used as weapons for thousands of years, it was not until 1915 at Ypres, France that an industrial chemical, chlorine, was used in World War I as an offensive weapon in significant quantity, causing mass casualties. From that point until today the development, detection, production and protection from chemical weapons has be an organized endeavor of many of the world's armed forces and in more recent times, non-governmental terrorist organizations. The number of Chemical Warfare Agents (CWAs) has steadily increased as research into more toxic substances continued for most of the 20 th century. Today there are over 70 substances including harassing agents like tear gas, incapacitating agents, and lethal agents like blister, blood, chocking, and nerve agents. The requirements for detecting chemical weapons vary depending on the context in which they are encountered and the concept of operation of the organization deploying the detection equipment. The US DoD, for example, has as a requirement, that US forces be able to continue their mission, even in the event of a chemical attack. This places stringent requirements on detection equipment. It must be lightweight (<2 lbs), detect a large array of chemical warfare agents and toxic industrial chemicals, detect and warn at concentration levels and time duration to prevent acute health effects, meet military ruggedness specifications and work over a wide range of temperature and humidity, and have a very high probability of detection with a similarly low probability of false positives. The current technology of choice to meet these stringent requirements is Ion Mobility Spectrometry. Many technologies are capable of detecting chemicals at the trace levels required and have been extensively developed for this application, including, but not limited to: mass spectroscopy, IR spectroscopy, RAMAN spectroscopy, MEMs micro-cantilever sensors, surface acoustic wave sensors, differential
Augustine, C.; Bain, R.; Chapman, J.; Denholm, P.; Drury, E.; Hall, D.G.; Lantz, E.; Margolis, R.; Thresher, R.; Sandor, D.; Bishop, N.A.; Brown, S.R.; Cada, G.F.; Felker, F.
The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a future through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).
Zhang, Yonghao; Jiang, Hui-Rong
Significant advances have been made in developing microfluidic polymerase chain reaction (PCR) devices in the last two decades. More recently, microfluidic microdroplet technology has been exploited to perform PCR in droplets because of its unique features. For example, it can prevent crossover contamination and PCR inhibition, is suitable for single-cell and single-molecule analyses, and has the potential for system integration and automation. This review will therefore focus on recent developments on droplet-based continuous-flow microfluidic PCR, and the major research challenges. This paper will also discuss a new way of on-chip flow control and a rational design simulation tool, which are required to underpin fully integrated and automated droplet-based microfluidic systems. We will conclude with a scientific speculation of future autonomous scientific discoveries enabled by microfluidic microdroplet technologies.
Lussky, Richard C.; Cifuentes, Raul F.; Siddappa, Ashajyothi M.
This is the second of two articles reviewing the history of newborn medicine. This article will discuss recent accomplishments in the field of newborn medicine, current health outcome data, and future challenges facing the fields of neonatal and perinatal medicine.
Full Text Available As the demand for wind energy continues to grow at exponential rates, reducing operation and maintenance (OM costs and improving reliability have become top priorities in wind turbine (WT maintenance strategies. In addition to the development of more highly evolved WT designs intended to improve availability, the application of reliable and cost-effective condition-monitoring (CM techniques offers an efficient approach to achieve this goal. This paper provides a general review and classification of wind turbine condition monitoring (WTCM methods and techniques with a focus on trends and future challenges. After highlighting the relevant CM, diagnosis, and maintenance analysis, this work outlines the relationship between these concepts and related theories, and examines new trends and future challenges in the WTCM industry. Interesting insights from this research are used to point out strengths and weaknesses in today’s WTCM industry and define research priorities needed for the industry to meet the challenges in wind industry technological evolution and market growth.
Tabata, Tomohiro; Tsai, Peii
The use of waste-to-energy technology as part of a municipal solid waste management strategy could reduce the use of fossil fuels and contribute to prevention of global warming. In this study, we examined current heat and electricity production by incineration plants in Japan for external use. Herein, we discuss specific challenges to the promotion of heat utilisation and future municipal solid waste management strategies. We conducted a questionnaire survey to determine the actual conditions of heat production by incineration plants. From the survey results, information of about 498 incineration plants was extracted. When we investigated the relationship between heat production for external use and population density where incineration plants were located, we found that regions with a population density heat. We also found that external use of such energy for factories, markets, and related use, was noted in cities with a population density of 2000 to 4000 persons (km(2))(-1). Several incineration plants have poor performance for heat production because there are few facilities near them to provide demand for the energy. This is the result of redundant capacity, and is reflected in the heat production performance. Given these results, we discussed future challenges to creating energy demand around incineration plants where there is presently none. We also examined the challenges involved in increasing heat supply beyond the present situation.
This viewgraph presentation reviews the process of thermoelectric energy conversion along with key technology needs and challenges. The topics include: 1) The Case for Thermoelectrics; 2) Advances in Thermoelectrics: Investment Needed; 3) Current U.S. Investment (FY07); 4) Increasing Thermoelectric Materials Conversion Efficiency Key Science Needs and Challenges; 5) Developing Advanced TE Components & Systems Key Technology Needs and Challenges; 6) Thermoelectrics; 7) 200W Class Lightweight Portable Thermoelectric Generator; 8) Hybrid Absorption Cooling/TE Power Cogeneration System; 9) Major Opportunities in Energy Industry; 10) Automobile Waste Heat Recovery; 11) Thermoelectrics at JPL; 12) Recent Advances at JPL in Thermoelectric Converter Component Technologies; 13) Thermoelectrics Background on Power Generation and Cooling Operational Modes; 14) Thermoelectric Power Generation; and 15) Thermoelectric Cooling.
Nguyen, Luat T.; Gilert, William P.
The foreseeable character of future within-visual-range air combat entails a degree of agility which calls for the integration of high-alpha aerodynamics, thrust vectoring, intimate pilot/vehicle interfaces, and advanced weapons/avionics suites, in prospective configurations. The primary technology-development programs currently contributing to these goals are presently discussed; they encompass the F-15 Short Takeoff and Landing/Maneuver Technology Demonstrator Program, the Enhanced Fighter Maneuverability Program, the High Angle-of-Attack Technology Program, and the X-29 Technology Demonstrator Program.
Cibulskis, Richard E; Alonso, Pedro; Aponte, John; Aregawi, Maru; Barrette, Amy; Bergeron, Laurent; Fergus, Cristin A; Knox, Tessa; Lynch, Michael; Patouillard, Edith; Schwarte, Silvia; Stewart, Saira; Williams, Ryan
2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality. A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium, and have contributed to substantial reductions in the burden of disease. Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$ 960 million to US$ 2.5 billion, allowing an expansion in malaria prevention, diagnostic testing and treatment programmes. In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets, compared to just 2 % in 2000. Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment. Malaria incidence rates have decreased by 37 % globally and mortality rates by 60 % since 2000. It is estimated that 70 % of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions. Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country. However, decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000; reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets. Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements. Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$ 900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014. Investments in malaria programmes can not
Pries, Caitlin Hicks; Hughes, Julie
Nothing brings out the best in eighth-grade physical science students quite like an engineering challenge. The wind turbine design challenge described in this article has proved to be a favorite among students with its focus on teamwork and creativity and its (almost) sneaky reinforcement of numerous physics concepts. For this activity, pairs of…
Perry, James L.; Vandenabeele, Wouter
This article takes stock of public service motivation research to identify achievements, challenges, and an agenda for research to build on progress made since 1990. After enumerating achievements and challenges, the authors take stock of progress on extant proposals to strengthen research. In addit
Perry, James L.; Vandenabeele, Wouter|info:eu-repo/dai/nl/323038816
This article takes stock of public service motivation research to identify achievements, challenges, and an agenda for research to build on progress made since 1990. After enumerating achievements and challenges, the authors take stock of progress on extant proposals to strengthen research. In
There are huge challenges facing the library and information science profession. Librarians need to be 'blended professionals' who can take their professional skills and experience, and adapt them to different business models and strategic challenges. This work intends to stimulate strategic and innovative thinking and questions the status quo.
Marquez, Jessica J.
Future exploration missions will require NASA to integrate more automation and robotics in order to accomplish mission objectives. This presentation will describe on the future challenges facing the human operator (astronaut, ground controllers) as we increase the amount of automation and robotics in spaceflight operations. It will describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. This presentation will outline future human-automation-robotic integration challenges.
Leung, Victor; Wang, Cho-Li; Shon, Taeshik; Advances in Complex Data Modeling and Computational Methods in Statistics
This book is about Future Information Technology, Application, and Service (FutureTech 2012 volume 2). The topics of FutureTech 2012 cover the current hot topics satisfying the world-wide ever-changing needs. The FutureTech 2012 is intended to foster the dissemination of state-of-the-art research in all future IT areas, including their models, services, and novel applications associated with their utilization. The FutureTech 2012 will provide an opportunity for academic and industry professionals to discuss the latest issues and progress in this area. In addition, the conference will publish high quality papers which are closely related to the various theories, modeling, and practical applications in many types of future technology. The main scope of FutureTech 2012 is as follows. Hybrid Information Technology Cloud and Cluster Computing Ubiquitous Networks and Wireless Communications Multimedia Convergence Intelligent and Pervasive Applications Security and Trust Computing IT Management and Service Bioinfo...
Ekberg, Peter; von Sydow, Axel
Since its breakthrough, the liquid crystal technology has continued to gain momentum and the LCD is today the dominating display type used in desktop monitors, television sets, mobile phones as well as other mobile devices. To improve production efficiency and enable larger screen sizes, the LCD industry has step by step increased the size of the mother glass used in the LCD manufacturing process. Initially the mother glass was only around 0.1 m2 large, but with each generation the size has increased and with generation 10 the area reaches close to 10 m2. The increase in mother glass size has in turn led to an increase in the size of the photomasks used - currently the largest masks are around 1.6 × 1.8 meters. A key mask performance criterion is the absence of "mura" - small systematic errors captured only by the very sensitive human eye. To eliminate such systematic errors, special techniques have been developed by Micronic Mydata. Some mura suppressing techniques are described in this paper. Today, the race towards larger glass sizes has come to a halt and a new race - towards higher resolution and better image quality - is ongoing. The display mask is therefore going through a change that resembles what the semiconductor mask went through some time ago: OPC features are introduced, CD requirements are increasing sharply and multi tone masks (MTMs) are widely used. Supporting this development, Micronic Mydata has introduced a number of compensation methods in the writer, such as Z-correction, CD map and distortion control. In addition, Micronic Mydata MMS15000, the world's most precise large area metrology tool, has played an important role in improving mask placement quality and is briefly described in this paper. Furthermore, proposed specifications and system architecture concept for a new generation mask writers - able to fulfill future image quality requirements - is presented in this paper. This new system would use an AOD/AOM writing engine and be
Olyaeemanesh, Alireza; Doaee, Shila; Mobinizadeh, Mohammadreza; Nedjati, Mina; Aboee, Parisa; Emami-Razavi, Seyed Hassan
Various decisions have been made on technology application at all levels of the health system in different countries around the world. Health technology assessment is considered as one of the best scientific tools at the service of policy- makers. This study attempts to investigate the current challenges of Iran's health technology assessment and provide appropriate strategies to establish and institutionalize this program. This study was carried out in two independent phases. In the first, electronic databases such as Medline (via Pub Med) and Scientific Information Database (SID) were searched to provide a list of challenges of Iran's health technology assessment. The views and opinions of the experts and practitioners on HTA challenges were studied through a questionnaire in the second phase which was then analyzed by SPSS Software version 16. This has been an observational and analytical study with a thematic analysis. In the first phase, seven papers were retrieved; from which, twenty- two HTA challenges in Iran were extracted by the researchers; and they were used as the base for designing a structured questionnaire of the second phase. The views of the experts on the challenges of health technology assessment were categorized as follows: organizational culture, stewardship, stakeholders, health system management, infrastructures and external pressures which were mentioned in more than 60% of the cases and were also common in the views. The identification and prioritization of HTA challenges which were approved by those experts involved in the strategic planning of the Department of Health Technology Assessment will be a step forward in the promotion of an evidence- based policy- making and in the production of comprehensive scientific evidence.
3D printing, one of the hottest cutting-edge interdisciplinary technologies, is projected to have revenue of $8.4 billion in 2020. #D printing technology will implement the concept of personalized medicine in medical healthcare industry and pharmaceutical fabrication. Organ printing, which it is defined as computer-aided, jet based 3D tissue-engineering of living human organs, is an interesting and challengeable field for 3D printing. Customized implants and prostheses can be produced in any ...
Fischer, Frank; Sutherland, Rosamund; Zirn, Lena
This book presents a key piece of the vision and strategy developed in STELLAR. It sets out a new mid-term agenda by defining Grand Challenges for research and development in technology-enhanced learning. Other than mere technology prizes, STELLAR Grand Challenges deal with problems at the interface of social and technical sciences. They pose problems that can be solved only in interdisciplinary collaboration. The descriptions of the Grand Challenge Problems were sent out to a number of stakeholders from industry, academia, and policy-making who responded with insightful, creative and critical comments bringing in their specific perspectives. This book will inspire everyone interested in TEL and its neighboring disciplines in their future projects. All of the listed problems, first hints with respect to the approach, measurable success indicators and funding sources are outlined. The challenges focus on what noted experts regard as important upcoming, pending, and innovative fields of research, the solution o...
Brandhorst, Henry W., Jr.
The future appears rich in missions that will extend the frontiers of knowledge, human presence in space, and opportunities for profitable commerce. Key to the success of these ventures is the availability of plentiful, cost effective electric power and assured, low cost access to space. While forecasts of space power needs are problematic, an assessment of future needs based on terrestrial experience has been made. These needs fall into three broad categories: survival, self sufficiency, and industrialization. The cost of delivering payloads to orbital locations from LEO to Mars has been determined and future launch cost reductions projected. From these factors, then, projections of the performance necessary for future solar and nuclear space power options has been made. These goals are largely dependent upon orbital location and energy storage needs. Finally the cost of present space power systems has been determined and projections made for future systems.
After more than fifty years of space activities, the near-Earth environment is polluted with man-made orbital debris. The collision between Cosmos 2251 and the operational Iridium 33 in 2009 signaled a potential collision cascade effect, also known as the "Kessler Syndrome", in the environment. Various modelling studies have suggested that the commonly-adopted mitigation measures will not be sufficient to stabilize the future debris population. Active debris removal must be considered to remediate the environment. This paper summarizes the key issues associated with debris removal and describes the technology and engineering challenges to move forward. Fifty-four years after the launch of Sputnik 1, satellites have become an integral part of human society. Unfortunately, the ongoing space activities have left behind an undesirable byproduct orbital debris. This environment problem is threatening the current and future space activities. On average, two Shuttle window panels are replaced after every mission due to damage by micrometeoroid or orbital debris impacts. More than 100 collision avoidance maneuvers were conducted by satellite operators in 2010 to reduce the impact risks of their satellites with respect to objects in the U.S. Space Surveillance Network (SSN) catalog. Of the four known accident collisions between objects in the SSN catalog, the last one, collision between Cosmos 2251 and the operational Iridium 33 in 2009, was the most significant. It was the first ever accidental catastrophic destruction of an operational satellite by another satellite. It also signaled the potential collision cascade effect in the environment, commonly known as the "Kessler Syndrome," predicted by Kessler and Cour-Palais in 1978 . Figure 1 shows the historical increase of objects in the SSN catalog. The majority of the catalog objects are 10 cm and larger. As of April 2011, the total objects tracked by the SSN sensors were more than 22,000. However, approximately 6000 of
India's post-independence policy of using science and technology for national development, and investment in research and development infrastructure resulted in success in space, atomic energy, missile development and supercomputing. Use of space technology has impacted directly or indirectly the vast majority of India's billion plus population. Developments in a number of emerging technologies in recent years hold the promise of impacting the future of ordinary Indians in significant ways, if a proper policy and enabling environment are provided. New telecom technologies - a digital rural exchange and a wireless access system - are beginning to touch the lives of common people. Development of a low-cost hand held computing device, use of hybrid telemedicine systems to extend modem healthcare to the unreached, and other innovative uses of IT at the grassroots also hold promise for the future. Biotechnology too has the potential to deliver cost-effective vaccines and drugs, but the future of GM crops is uncertain due to growing opposition. Some of these emerging technologies hold promise for future, provided a positive policy and enabling environment. (author)
Poupat, Jean-Luc; Chevalier, Laurent; Monchaux, David; Le Meur, Patrick
With the support of CNES DLA as operator, and Airbus DS Space System as architect, Airbus DS Electronics in Elancourt has developed a modular platform to evaluate new technologies for future avionics.This paper presents the Avionic-X project that has initiated this development, the modular platform itself and the status on this activity performed on this evaluation platform which has allowed the use of European technologies such as ARM processing cores or TTEthernet communication bus.
Harmsen, Hanne; Sonne, Anne-Mette; Jensen, Birger Boutrup
What will the impact of science be ten years from now in the food industry? Large or overwhelming most people will probably agree. But before we can be any more specific, we need to address the questions of what type or aspect of science or technology we have in mind and secondly, what kind...... of impact we are talking about. Since there are a large number of technologies whose impact can be relevant to study a variety of different angles, this is indeed a challenging task. In this paper, we consequently do not start by looking at any particular technology and discuss which impact it will have...... in the future. Our approach is to construct a number of likely pictures of the future and then look at the role and impact of technology and science in each of the pictures. We do this by using an industry level scenario technique, in which we rely heavily on expert and industry inputs representing both...
Meng Chuan Lee
Full Text Available Charge storage nonvolatile memory (NVM is one of the main driving forces in the evolution of IT handheld devices. Technology scaling of charge storage NVM has always been the strategy to achieve higher density NVM with lower cost per bit in order to meet the persistent consumer demand for larger storage space. However, conventional technology scaling of charge storage NVM has run into many critical reliability challenges related to fundamental device characteristics. Therefore, further technology scaling has to be supplemented with novel approaches in order to surmount these reliability issues to achieve desired reliability performance. This paper is focused on reviewing critical research findings on major reliability challenges and technical solutions to mitigate technology scaling challenges of charge storage NVM. Most of these technical solutions are still in research phase while a few of them are more mature and ready for production phase. Three of the mature technical solutions will be reviewed in detail, that is, tunnel oxide top/bottom nitridation, nanocrystal, and phase change memory (PCM. Key advantages and reported reliability challenges of these approaches are thoroughly reviewed in this paper. This paper will serve as a good reference to understand the future trend of innovative technical solutions to overcome the reliability challenges of charge storage NVM due to technology scaling.
First presented at a United States Department of Agriculture (USDA) conference on renewable resources, this material includes information and discussion on critical issues, policies, and future alternatives for natural resources in the United States. (CO)
Pfeilmeier, Sebastian; Caly, Delphine L; Malone, Jacob G
Plant infection is a complicated process. On encountering a plant, pathogenic microorganisms must first adapt to life on the epiphytic surface, and survive long enough to initiate an infection. Responsiveness to the environment is critical throughout infection, with intracellular and community-level signal transduction pathways integrating environmental signals and triggering appropriate responses in the bacterial population. Ultimately, phytopathogens must migrate from the epiphytic surface into the plant tissue using motility and chemotaxis pathways. This migration is coupled with overcoming the physical and chemical barriers to entry into the plant apoplast. Once inside the plant, bacteria use an array of secretion systems to release phytotoxins and protein effectors that fulfil diverse pathogenic functions (Fig. ) (Melotto and Kunkel, ; Phan Tran et al., ). As our understanding of the pathways and mechanisms underpinning plant pathogenicity increases, a number of central research challenges are emerging that will profoundly shape the direction of research in the future. We need to understand the bacterial phenotypes that promote epiphytic survival and surface adaptation in pathogenic bacteria. How do these pathways function in the context of the plant-associated microbiome, and what impact does this complex microbial community have on the onset and severity of plant infections? The huge importance of bacterial signal transduction to every stage of plant infection is becoming increasingly clear. However, there is a great deal to learn about how these signalling pathways function in phytopathogenic bacteria, and the contribution they make to various aspects of plant pathogenicity. We are increasingly able to explore the structural and functional diversity of small-molecule natural products from plant pathogens. We need to acquire a much better understanding of the production, deployment, functional redundancy and physiological roles of these molecules. Type III
Future small satellite systems for both Earth observation as well as deep-space exploration are greatly enabled by the technological advances in deep sub-micron microelectronics technologies. Whereas these technological advances are being fueled by the commercial (non-space) industries, more recently there has been an exciting new synergism evolving between the two otherwise disjointed markets. In other words, both the commercial and space industries are enabled by advances in low-power, highly integrated, miniaturized (low-volume), lightweight, and reliable real-time embedded systems. Recent announcements by commercial semiconductor manufacturers to introduce Silicon On Insulator (SOI) technology into their commercial product lines is driven by the need for high-performance low-power integrated devices. Moreover, SOI has been the technology of choice for many space semiconductor manufacturers where radiation requirements are critical. This technology has inherent radiation latch-up immunity built into the process, which makes it very attractive to space applications. In this paper, we describe the advanced microelectronics and avionics technologies under development by NASA's Deep Space Systems Technology Program (also known as X2000). These technologies are of significant benefit to both the commercial satellite as well as the deep-space and Earth orbiting science missions. Such a synergistic technology roadmap may truly enable quick turn-around, low-cost, and highly capable small satellite systems for both Earth observation as well as deep-space missions.
Leonid Davidovich Gitelman
Full Text Available The article presents the results of the authors’ study based on the hypothesis that aaddressing the multidimensional highly complex tasks of technological modernization and new industry against the background of a wave of breakthrough innovations is only possible within the framework of proactive management. Its methodological, instrumental and competence basis results from «smart» partnership of regional science, education, and business. In this case, the management сconsulting of a new type, being fundamentally different from the traditional one, plays the role of the partnership coordinator. These differences are expressed in specific intellectual logistics and organizational architecture of consulting projects, close connection to universities, innovation centres and various research structures of the region as well as the high specialization, which is reached by the involvement of the virtual teams of cross-disciplinary experts in the developments, the flexible products designed on the basis of the modular principle. In this regard, the study presents a number of new scientific results proving the hypothesis. The paper substantiates the approach to the organization and methodology of consulting activities for complex, rapidly developing systems which requires expanding the range of competencies and scope of the interaction of various actors — carriers of interdisciplinary knowledge. In accordance with this approach, the authors introduce the concept of integratory consulting for advanced development that offers a package of intellectual services for addressing challenges of the future. We have developed the methodology of the integrated system of research, consultations, training and transforming action that makes it possible to generate pre-emptive actions amid crisis, risk and threats. The article has proposed and tested an organizational mechanism of cooperation between parties (science, education, business involved in smart
The NASA Fundamental Aeronautics Fixed Wing (FW) Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advances in multidisciplinary technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. The presentation will highlight the FW Project vision of revolutionary systems and technologies needed to achieve the challenging goals of aviation. Specifically, the primary focus of the FW Project is on the N+3 generation that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe.
On May 4--7, 1993, nine federal agencies sponsored a four-day meeting on Grand Challenge applications and software technology. The objective was to bring High-Performance Computing and Communications (HPCC) Grand Challenge applications research groups supported under the federal HPCC program together with HPCC software technologists to: discuss multidisciplinary computational science research issues and approaches, identify major technology challenges facing users and providers, and refine software technology requirements for Grand Challenge applications research. The first day and a half focused on applications. Presentations were given by speakers from universities, national laboratories, and government agencies actively involved in Grand Challenge research. Five areas of research were covered: environmental and earth sciences; computational physics; computational biology, chemistry, and materials sciences; computational fluid and plasma dynamics; and applications of artificial intelligence. The next day and a half was spent in working groups in which the applications researchers were joined by software technologists. Nine breakout sessions took place: I/0, Data, and File Systems; Parallel Programming Paradigms; Performance Characterization and Evaluation of Massively Parallel Processing Applications; Program Development Tools; Building Multidisciplinary Applications; Algorithm and Libraries I; Algorithms and Libraries II; Graphics and Visualization; and National HPCC Infrastructure.
Passey, Don; Laferrière, Thérèse; Ahmad, Manal Yazbak-Abu; Bhowmik, Miron; Gross, Diana; Price, Janet; Resta, Paul; Shonfeld, Miri
In this conceptual paper, we consider issues and challenges of third party and governmental organisations in planning and implementing access to and uses of digital technologies for learning and teaching in developing countries. We consider failures and weaknesses in the planning and implementation processes highlighted by research in developed…
Zimmerman, Vernon K.
Indicates that the challenge to schools of business education is to assist national and international economies in the transition to a high technological age and to ensure that courses and programs recognize the fundamental changes in the economic environment and prepare students for management in the 21st century. (JOW)
Gilbert, Tricia; Jin, Jenny; Berger, Jason; Henriksen, Steve
The following NASA Contractor Report documents the in-depth studies on select technologies that could support long-term aeronautical mobile communications operating concepts. This work was performed during the third and final phase of NASA s Technology Assessment for the Federal Aviation Administration (FAA)/EUROCONTROL Future Communications Study (FCS) under a multiyear NASA contract. It includes the associated findings of ITT Corporation and NASA Glenn Research Center to the FAA as of the end of May 2007. The activities documented in this report focus on three final technology candidates identified by the United States, and were completed before sufficient information about two additional technology candidates proposed by EUROCONTROL was made available. A separate report to be published by NASA/CR-2008-215144, entitled Final Report on Technology Investigations for Provision of Future Aeronautical Communications will include an assessment of all five final candidate technologies considered by the U.S. agencies (FAA and NASA) and EUROCONTROL. It will also provide an overview of the entire technology assessment process, including final recommendations. All three phases of this work were performed in compliance with the Terms of Reference for the Action Plan number 17 (AP-17) cooperative research agreement among EUROCONTROL, FAA, and NASA along with the general guidance of the FAA and EUROCONTROL available throughout this study.
An exploration of (I) alternative perspectives toward recent innovations in reproductive technology: support for new techniques for the sake of the kind of feminist future they facilitate; unqualified opposition despite therapeutic benefit to individual women; or qualified opposition depending upon specific threats to women's interests and (II) relationships between these positions and values bound up with mothering practices.
Networking technologies have been changing the life of people in their private residential space. With the arrival of high definition (HD) multimedia services and broadband communications into the living space, future home networks are expected to support high speed device-to-device connectivity wit
Wan Fariza Alyati Wan Zakaria
Full Text Available In this article, we attempt at analysing the thoughts of Alvin Toffler. Toffler is a prominent futurist and the proponent of the theory of ‘The Third Wave society’. In his theory, Toffler has explicitly discussed the role of knowledge and technology in effecting changes and thus shaping the coming of the new type of society in the future.
The hypothesis of this paper is that industrial transformation in the Danish construction sector needs in the future to focus on integrating building services technologies into the buildings. This can be illustrated by analysing historical developments in building services usage, exploring desi...
Networking technologies have been changing the life of people in their private residential space. With the arrival of high definition (HD) multimedia services and broadband communications into the living space, future home networks are expected to support high speed device-to-device connectivity
Full Text Available This paper reviews the current state and development of different numerical model classes that are used to simulate the global atmospheric system, particularly Earth’s climate and climate-chemistry connections. The focus is on Chemistry-Climate Models. In general, these serve to examine dynamical and chemical processes in the Earth atmosphere, their feedback, and interaction with climate. Such models have been established as helpful tools in addition to analyses of observational data. Definitions of the global model classes are given and their capabilities as well as weaknesses are discussed. Examples of scientific studies indicate how numerical exercises contribute to an improved understanding of atmospheric behavior. There, the focus is on synergistic investigations combining observations and model results. The possible future developments and challenges are presented, not only from the scientific point of view but also regarding the computer technology and respective consequences for numerical modeling of atmospheric processes. In the future, a stronger cross-linkage of subject-specific scientists is necessary, to tackle the looming challenges. It should link the specialist discipline and applied computer science.
Di Meglio, Alberto; Purcell, Andrew
This whitepaper describes the major IT challenges in scientific research at CERN and several other European and international research laboratories and projects. Each challenge is exemplified through a set of concrete use cases drawn from the requirements of large-scale scientific programs. The paper is based on contributions from many researchers and IT experts of the participating laboratories and also input from the existing CERN openlab industrial sponsors. The views expressed in this document are those of the individual contributors and do not necessarily reflect the view of their organisations and/or affiliates.
Tyagi, Rajesh Kumar
This chapter presents challenges faced by service businesses while implementing a measurement system. A review of existing frameworks is presented and a new framework, the Service Scorecard, is introduced. The Service Scorecard is an adaptation of the Six Sigma Business Scorecard for the service sector. The framework has also been influenced by existing frameworks such as the Malcom Baldrige award criteria, the Balanced Scorecard, the European Quality award and the Service Profit Chain model. The seven elements of the Service Scorecard are Growth, Leadership, Acceleration, Collaboration, Innovation, Execution, and Retention. The examples of measurement systems are presented with concrete real-world case examples. Final thoughts and the challenges faced are also presented.
Tillemann, Levi; Beck, Fredric; Brodrick, James; Brown, Austin; Feldman, David; Nguyen, Tien; Ward, Jacob
For decades, America has anticipated the transformational impact of clean energy technologies. But even as costs fell and technology matured, a clean energy revolution always seemed just out of reach. Critics often said a clean energy future would "always be five years away." This report focuses on four technology revolutions that are here today. In the last five years they have achieved dramatic reductions in cost and this has been accompanied by a surge in consumer, industrial and commercial deployment. Although these four technologies still represent a small percentage of their total market, they are growing rapidly. The four key technologies this report focuses on are: onshore wind power, polysilicon photovoltaic modules, LED lighting, and electric vehicles.
Elimelech, Menachem; Phillip, William A
In recent years, numerous large-scale seawater desalination plants have been built in water-stressed countries to augment available water resources, and construction of new desalination plants is expected to increase in the near future. Despite major advancements in desalination technologies, seawater desalination is still more energy intensive compared to conventional technologies for the treatment of fresh water. There are also concerns about the potential environmental impacts of large-scale seawater desalination plants. Here, we review the possible reductions in energy demand by state-of-the-art seawater desalination technologies, the potential role of advanced materials and innovative technologies in improving performance, and the sustainability of desalination as a technological solution to global water shortages.
Academic institutions are facing a crisis in scholarly publishing at multiple levels: presses are stressed as never before, library budgets are squeezed, faculty are having difficulty publishing their work, and promotion and tenure committees are facing a range of new ways of working without a clear sense of how to understand and evaluate them. Planned Obsolescence is both a provocation to think more broadly about the academy’s future and an argument for reconceiving that future in more communally-oriented ways. Facing these issues head-on, Kathleen Fitzpatrick focuses on the technological changes—especially greater utilization of internet publication technologies, including digital archives, social networking tools, and multimedia—necessary to allow academic publishing to thrive into the future. But she goes further, insisting that the key issues that must be addressed are social and institutional in origin. Springing from original research as well as Fitzpatrick’s own hands-on experiments in ne...
Cutts, J.; Balint, T.; Kolawa, El.; Peterson, C.
Solar System exploration is driven by high priority science goals and objectives at diverse destinations, as described in the NRC Decadal Survey and in NASA's 2006 Solar System Exploration (SSE) Roadmap. Proposed missions to these targets encounter extreme environments, including high or low temperatures, high pressure, corrosion, high heat flux, radiation and thermal cycling. These conditions are often coupled, such as low temperature and high radiation at Europa; and high temperature and high pressure near the surface of Venus. Mitigation of these environmental conditions frequently reaches beyond technologies developed for terrestrial applications, for example, by the automotive and oil industries. Therefore, space agencies require dedicated technology developments to enable these future missions. Within NASA, proposed missions are divided into three categories. Competed small (Discovery class) and medium (New Frontiers class) missions are cost capped, thus limiting significant technology developments. Therefore, large (Flagship class) missions are required not only to tackle key science questions which can't be addressed by smaller missions, but also to develop mission enabling technologies that can feed forward to smaller missions as well. In a newly completed extreme environment technology assessment at NASA, we evaluated technologies from the current State of Practice (SoP) to advanced concepts for proposed missions over the next decades. Highlights of this report are discussed here, including systems architectures, such as hybrid systems; protection systems; high temperature electronics; power generation and storage; mobility technologies; sample acquisition and mechanisms; and the need to test these technologies in relevant environments. It is expected that the findings - documented in detail in NASA's Extreme Environments Technologies report - would help identifying future technology investment areas, and in turn enable or enhance planned SSE missions
Bruce Matthews; Todd R. LaPorte
This paper explores the implications of moderately expanding plutonium "pit" production capability within the strongly R&D culture of Los Alamos National Laboratory, especially in terms of the lab's current capacity or "fitness for the future" in which institutional stewardship of the nation's nuclear deterrent capability becomes a primary objective. The institutional properties needed to assure "future fitness" includes the organizational requisites highly reliable operations and sustained institutional constancy in a manner that evokes deep public trust and confidence. Estimates are made of the degree to which the key Division and most relevant Program office in this evolution already exhibits them.
There is a lack of information on the history of soil science in developing countries, such as Mexico. Scientists, farmers, and government agencies can use this type of information to identify the benefits, current state of understanding, and recognize the challenges associated with managing soil r...
Hall, Richard; Agarwal, Renu; Green, Roy
Purpose -- The purpose of this paper is to undertake a survey of the external and internal forces changing the nature of business schools and business education. It aims to investigate how management education responds to increasing productivity, innovation and capability challenges, examine how MBA programs currently meet these demands, and how…
Full Text Available Is future teachers’ contact with the physical environment significant enough for them to choose to educate their students about sustainability? These digital natives stand out from previous generations by their way of living, working and learning. Does the use of ICT by these young adults contribute to distancing them from the physical environment? Are future teachers, better informed thanks to technology, committed to environmental action? This research based on grounded theory was aimed at understanding future teachers’ relationships with physical and technological environments. The analysis of individual and group interviews with Moncton and Montreal teacher education students reveals that future teachers maintain a sporadic relation to the natural environment. They are still conscious that nature provides them with calmness, rejuvenation, and beauty. The Internet, visited at least two hours daily, offers them distraction, social affiliation, and personalized information, as well as facilitates their tasks and contact with the World. Future teachers are critical and cautious in their use of ICT, but are not much involved in the environmental cause. This research emphasizes the need to work on future teachers’ relationship to the physical environment with outdoor activities to get to know, appreciate, analyze, and improve the natural and urban environments.Key words: education, environment, Social networks,pedagogy.
Radiology has gained an enviable position among medial specialities. Developments in new technology expand its horizons and the volume of radiologic imaging techniques and procedures increase far more than the overall growth in health care services. In this position radiology has become a prime target for restrictions, cutbacks, controlled financing in an area of managed care and new national health care policy based on partially fixed budgets. Future health care takers have to choose the best available diagnostic and therapeutic techniques. Evidence based medicine, cost-utility analysis, diagnostic performance analysis, patient outcome analysis, technology assessment and guidelines for practice are means to guide us through our obligatory choice. Our major objective is to use the most performant available imaging technique or intervention to achieve the best possible outcome for our patient at lower possible costs. A strategic response from radiologists is required to meet the imperatives of this new management situation. They must do far more than interpret imaging procedures. They must work as efficient managers of imaging resources, organise their practices and define their marketing-strategies using the different, so-called, marketing-mix elements. The challenges will be great but the rewards are worth our best efforts. In this article we highlight the marketing responsibilities of future radiologists and their clinical practice in this new socio-economic environment and we present different useful marketing tools.
Shiltsev, V; Romanenko, A; Valishev, A; Zwaska, R
Recent P5 report indicated the accelerator-based neutrino and rare decay physics research as a centrepiece of the US domestic HEP program. Operation, upgrade and development of the accelerators for the near-term and longer-term particle physics program at the Intensity Frontier face formidable challenges. Here we discuss accelerator physics and technology research toward future multi-MW proton accelerators.
Nygaard, Ivan; Hansen, Ulrich Elmer
The strong focus in climate negotiations on the transfer and diffusion of technologies as ameans to mitigate and adapt to climate change has entailed various programs to promote the transfer and diffusion of climate technologies, including the Technology Needs Assessment project (TNA). Despite...... a framework for categorizing technologies according to the types of markets and non-markets in which they are diffused. While the framework has contributed to a higher degree of ‘market literacy’ among national stakeholders, four challenges in categorizing technologies have been identified: i) technologies...
Reilly, Elizabeth C.
To enter a future that waits to be born, educational leaders must continually assess their own ethical stance as well as that of the organizations they serve. Three frames form a model for examining the ethics of both individual and organization, with internal monologue and engaged conversation as the means for reflection and action.
Wann, Samuel; Tunio, Javed
Imaging is one of the most important accomplishments of medicine during the last 1000 years. The contribution of modern imaging to progress in the delivery of health care is unquestioned. However, we need to refine our use of imaging, limiting its use to those occasions when it can contribute directly or indirectly to improving and lengthening the lives of patients. Technology prowess in imaging alone is not sufficient to deliver value to individuals or to society. Continued investment in imaging technology requires critical appraisal of its use in clinical decision making and patient outcomes.
Seigel, S. [National Library of Medicine, Bethesda, MD (United States)
Issues related to developing information resources for assessing the health effects from chemical exposure include the question of how to address the individual political issues relevant to identifying and determining the timeliness, scientific credibility, and completeness of such kinds of information resources. One of the important ways for agencies to share information is through connection tables. This type of software is presently being used to build information products for some DHHS agencies. One of the challenges will be to convince vendors of data of the importance of trying to make data files available to communities that need them. In the future, information processing will be conducted with neural networks, object-oriented database management systems, and fuzzy-set technologies, and meta analysis techniques.
Baas, Andreas C. W.; Wiggs, Giles F. S.; Claudin, Philippe
On this tenth anniversary of the Aeolian Processes & Landforms session at the EGU the original conveners review and reflect on the recent achievements and expansion in aeolian geomorphological research, focussing on advances in our understanding of sand transport processes, dune development and dynamics, and the mechanisms and scalings involved. This talk will highlight the variety and impact of the dramatic increase in the extent and interest of research on aeolian processes and landforms in the last ten years, including the increasingly strong community presence at international meetings, the diversity and extent of collaborations across subject boundaries, and the application of new measurement technologies and mathematical approaches. We conclude with a forward-looking prospectus of exciting future challenges and open research questions.
Bergström, Lars; Goulding, Keith W T
Producing an adequate quantity of healthy food without polluting the environment is a serious challenge for future agriculture around the world. The Food 21 research program in Sweden has researched all aspects--economic, environmental, and social--of sustainable farming systems. This paper presents some of the research from that and other relevant international research programs that have focused on better nutrient-use efficiency, especially for nitrogen and phosphorus. It shows that a range of sustainable solutions to nutrient-use efficiency exists, some of which are complex but some very simple. Government policies, including subsidies; research and technology; and public acceptance of farming practices all combine to create these solutions. Participatory approaches to knowledge transfer are needed, in which scientists, policy makers, farmers, advisers, and consumers exchange information and together build sustainable farming systems.
Perez, Mario R.
Over the next decade, NASA's Astrophysics Division expects to undertake robotic or unmanned space flight missions that will explore the nature of the universe at its largest scales, its earliest moments, and its most extreme conditions. Current innovative and maturation technology programs are being conducted by NASA's Astrophysics Division to fill the technology gaps identified by the community. One of these efforts was to establish the Strategic Astrophysics Technology (SAT) program to support the maturation of key technologies. In this paper, these technology programs are described; in particular the SAT program will be presented describing the process to establish priorities, the technology management components, and the efforts to move these technologies into mission concepts and flight missions. The technology roadmap for a large mission concept such as ATLAST is presented as an example of the technology gaps derived and identified from these analyses, which could focus future efforts and investment priorities. Finally, the NASA preparation for the next decade, which will study and mature four large mission concepts, is briefly outlined.
Full Text Available Solar energy is commonly seen as a future energy source with significant potential. Ruthenium, gallium, indium and several other rare elements are common and vital components of many solar energy technologies, including dye-sensitized solar cells, CIGS cells and various artificial photosynthesis approaches. This study surveys solar energy technologies and their reliance on rare metals such as indium, gallium, and ruthenium. Several of these rare materials do not occur as primary ores, and are found as byproducts associated with primary base metal ores. This will have an impact on future production trends and the availability for various applications. In addition, the geological reserves of many vital metals are scarce and severely limit the potential of certain solar energy technologies. It is the conclusion of this study that certain solar energy concepts are unrealistic in terms of achieving TW scales.
Harmsen, Hanne; Sonne, Anne-Mette; Jensen, Birger Boutrup
the 'technology push' and 'market pull representatives', whom we feel are both very important basic driving forces. The aim is to get an idea of the very different roles science or technology can take in the near future for a specific industry, in this case the Danish food industry and present a methodological......What will the impact of science be ten years from now in the food industry? Large or overwhelming most people will probably agree. But before we can be any more specific, we need to address the questions of what type or aspect of science or technology we have in mind and secondly, what kind...... of impact we are talking about. Since there are a large number of technologies whose impact can be relevant to study a variety of different angles, this is indeed a challenging task. In this paper, we consequently do not start by looking at any particular technology and discuss which impact it will have...
Bavik Ali; Duncan Tara
Defining and measuring organizational culture (OC) is of paramount importance to organizations because a strong culture could potentially increase service quality and yield sustainable competitive advantages. However, such process could be challenging to managers because the scope of OC has been defined differently across disciplines and industries, which has led to the development of various scales for measuring OC. In addition, previously developed OC scales may also not be fully applicable...
Hack, Catherine; Kendall, Gary
It is widely predicted that the application of high-throughput technologies to the quantification and identification of biological molecules will cause a paradigm shift in the life sciences. However, if the biosciences are to evolve from a predominantly descriptive discipline to an information science, practitioners will require enhanced skills in…
Jankowska, Maria Anna; Marcum, James W.
There is growing concern that a variety of factors threaten the sustainability of academic libraries: developing and preserving print and digital collections, supplying and supporting rapidly changing technological and networking infrastructure, providing free services, maintaining growing costs of library buildings, and lowering libraries'…
Verma, Sunil K; Goswami, Gajendra K
Since the discovery of DNA fingerprinting technology in 1985 it has been used extensively as evidence in the court of law world-wide to establish the individual identity both in civil and criminal matters. In India, the first case of parentage dispute solved by the use of DNA fingerprinting technology was in 1989. Since then till date, the DNA technology has been used not only to resolve the cases of paternity and maternity disputes, but also for the establishment of individual identity in various criminal cases and for wildlife forensic identification. Since last half a decade, India is exercising to enact legislation on the use of DNA in the judicial realm and the draft 'Human DNA Bill-2012' is pending in the parliament. Largely, the promoters of forensic DNA testing have anticipated that DNA tests are nearly infallible and DNA technology could be the greatest single advance step in search for truth, conviction of the perpetrator, and acquittal of the innocent. The current article provides a comprehensive review on the status of DNA testing in India and elucidates the consequences of the admissibility of DNA as 'evidence' in the judicial dominion. In this backdrop of civil and criminal laws and changing ethical and societal attitudes, it is concluded that the DNA legislation in India and world-wide needs to be designed with utmost care.
Kelly, Gary F.
In view of the present state of affairs in the field, it is time for reassessment and professional debate about what sexuality education can and should be. There have been significant cultural shifts brought about by recent technological development, global awareness of sexual issues, and the characteristics of the current younger generation.…
Full Text Available 3D printing, one of the hottest cutting-edge interdisciplinary technologies, is projected to have revenue of $8.4 billion in 2020. #D printing technology will implement the concept of personalized medicine in medical healthcare industry and pharmaceutical fabrication. Organ printing, which it is defined as computer-aided, jet based 3D tissue-engineering of living human organs, is an interesting and challengeable field for 3D printing. Customized implants and prostheses can be produced in any imaginable geometry through the translation of radiological images of patients into digital.stl 3D print files. The creation of anatomical models based on the patient’s pathological conditions using 3D printing technologies would provide good models for training and to design surgical approaches. Hence, 3D printing not only will transform medical healthcare industry but also promises new converging technologies in the field of regenerative medicine.
Neethling, J B; Clark, D; Pramanik, A; Stensel, H D; Sandino, J; Tsuchihashi, R
The WERF Nutrient Challenge is a multi-year collaborative research initiative established in 2007 to develop and provide current information about wastewater treatment nutrients (specifically nitrogen and phosphorus in wastewater), their characteristics, and bioavailability in aquatic environments to help regulators make informed decisions. The Nutrient Challenge will also provide data on nutrient removal so that treatment facilities can select sustainable, cost-effective methods and technologies to meet permit limits. To meet these goals, the Nutrient Challenge has teamed with a wide array of utilities, agencies, consultants, universities and other researchers and practitioners to collaborate on projects that advance these goals. The Nutrient Challenge is focusing on a different approach to collaborating and leveraging resources (financial and intellectual) on research projects by targeting existing projects and research that correspond with its goals and funding those aspects that the Nutrient Challenge identified as a priority. Because the Nutrient Challenge is focused on collaboration, outreach is an absolutely necessary component of its effectiveness. Through workshops, webinars, a web portal and online compendium, published papers, and conference lectures, the Nutrient Challenge is both presenting important new information, and soliciting new partnerships.
Senka Hočevar Ciuha
Full Text Available Everyday we witness uncertain future. Modern sociologists today's social situation name as "liquid modern period", "end of certainty","world without ligatures". As this is a time of social and economic bifurcation, it is also a time of opportunities. The article outlines the social background of modern and postmodern categories, with consequences which are visible in the educational structure of schools and in a psychology of a modern human person. The discrepancy between dialectic of narrative knowledge and didactics as pragmatics of scientific knowledge which is legitimised through institutional network of language games lies the cause of storm chaotic economic social conditions and human moral values breakage. Holistic strategy, which primarly understands a man as an integrated human being, we set up lifelong education and learning as a corrective model of the current educational system and vision for the future.
Hubbell, John A E
University-based veterinary teaching hospitals must change to maintain their viability. A number of factors both internal and external to universities and the veterinary profession have contributed to the need for change. A task force formed by the Association of American Veterinary Medical Colleges and the American Association of Veterinary Clinicians was convened to identify the issues and propose individual and collective strategies for the future. Primary issues include a shortage of faculty and staff, the nature of the case load, the need for fiscal management strategies, and the need to manage stakeholder expectations. The majority of the proposed strategies for the future will be managed individually by the colleges. Proposed collective strategies center on increasing the number of specialists and improving recruitment and retention of faculty and staff.
Kristensen, L; Støier, S; Würtz, J; Hinrichsen, L
With an increasing world population, an increase in affluence and a substantial growth in the demand for high quality protein, the meat sector faces a fantastic but challenging century. New scientific knowledge, technology and creative minds are the main ingredients in order to reach out for this great opportunity. Efficiency all the way from breeding and farming to processing and dispatch is crucial for success. Technology has brought us far, and there is still a huge potential for increased efficiency by implementing best practices on a global scale. New challenges include: hyper flexible automation, more accurate and faster measurement systems and meeting special consumer demands already at the production line. Systems for optimal animal welfare will be even more important and sustainability is no longer a consumer trend but a license to operate. The scientific meat society must provide knowledge and technology so we together can reach out for a seemingly bright future.
In the last ten years there has been much speculation about the role of e-books and e-book readers. This paper will look at the impact of e-book readers on publishing and reading, the types of e-book readers, their advantages and disadvantages. Some ideas for future e-books and e-book readers and their use in the library and classroom will be…
Okazaki, Shintaro; Taylor, Charles R. (Charles Robert)
Purpose – The primary aim of this article is to identify theoretical foundations that can be used in research on social media in the context of international advertising research. An additional objective is to identify future research directions for theory building in this research area. Design/methodology/approach – The article draws on the extant literature to identify three key theoretical foundations that can be used in research on advertising in media from an advertising p...
Full Text Available Present water shortage is one of the primary world issues, and according to climate change projections, it will be more critical in the future. Since water availability and accessibility are the most significant constraining factors for crop production, addressing this issue is indispensable for areas affected by water scarcity. Current and future issues related to “water scarcity” are reviewed in this paper so as to highlight the necessity of a more sustainable approach to water resource management. As a consequence of increasing water scarcity and drought, resulting from climate change, considerable water use for irrigation is expected to occur in the context of tough competition between agribusiness and other sectors of the economy. In addition, the estimated increment of the global population growth rate points out the inevitable increase of food demand in the future, with an immediate impact on farming water use. Since a noteworthy relationship exists between the water possessions of a country and the capacity for food production, assessing the irrigation needs is indispensable for water resource planning in order to meet food needs and avoid excessive water consumption.
Bibin Lawrence R,
Full Text Available Considering the difficulties in planar CMOS transistor scaling to secure an acceptable gate to channel control FinFET based multi-gate (MuGFET devices have been proposed as a technology option for replacing the existing technology. The desirability of FinFET that it’s operation principle is same as CMOS process. This permits to lengthening the gate scaling beyond the planar transistor limits, sustaining a steep subthreshold slope, better performance with bias voltage scaling and good matching due to low doping concentration in the channel. There are, still, several challenges and limitations that FinFET technology has to face to be competitive with other technology options: Fin shape, pitch, isolation, doping, crystallographic orientation and stressing as well as device parasitic, performance and patterning approaches will be discussed.
This paper review the present technologies for the fabrication of solar cells and modules based on the most common semiconductors namely silicon, CuInGaSe(S) and CdTe materials as well as on III-V concentrated photovoltaic cells and modules. For silion technology, we give insights on the growth of monocrystalline and multicrystalline silicon wafers and then we describe the most common solar cells designs and how to fabricate them. We also provide information about the fabrication of silicon modules and their performances. As for the thin-films solar cells, we present the structurale and optical properties of the CIGS and CdTe materials as well as the solar cell structures. The multi-junction concept cell that involves several III-V materials of different bandgaps is also described, and data on their fabrication, performances and mounting as modules are presented. Finally, a short outlook on the coming materials for solar cells is provided.
Moshelion, Menachem; Altman, Arie
Advances in understanding plant biology, novel genetic resources, genome modification, and omics technologies generate new solutions for food security and novel biomaterials production under changing environmental conditions. New gene and germplasm candidates that are anticipated to lead to improved crop yields and other plant traits under stress have to pass long development phases based on trial and error using large-scale field evaluation. Therefore, quantitative, objective, and automated screening methods combined with decision-making algorithms are likely to have many advantages, enabling rapid screening of the most promising crop lines at an early stage followed by final mandatory field experiments. The combination of novel molecular tools, screening technologies, and economic evaluation should become the main goal of the plant biotechnological revolution in agriculture. Copyright © 2015 Elsevier Ltd. All rights reserved.
Asha M. PAWAR
Big data is a data with large size means it has large volume, velocity and variety. Now a day's big data is expanding in a various science and engineering fields. And so there are many challenges to manage and analyse big data using various tools. This paper introduces the big data and its Characteristic concepts and Next section elaborates about the Challenges in Big data. In Particular, wed discuss about the technologies used in big data Analysis and Which Tools are mainly used to analyse t...
Nolan, Heather; Wang, Dongfang; Zwischenberger, Joseph B.
There exists a growing demand for new technology that can take over the function of the human lung, from assisting an injured or recently transplanted lung to completely replacing the native organ. Many obstacles must be overcome to achieve the lofty goals and expectations of such a device. An artificial lung must be able to sustain the gas exchange requirements of a normal functioning lung. Pursuant to this purpose, the device must maintain appropriate blood pressure, decrease injury to bloo...
Brodersen, Søsser Grith Kragh; Lindegaard, Hanne
Abstract: In the mid-2000s, the term Patient 2.0 began to be used to denote a new patient role: empowered patients were expected to engage with various types of information and specific technologies in order to manage their own illnesses. Headlines such as Future patients will take care of themse......Abstract: In the mid-2000s, the term Patient 2.0 began to be used to denote a new patient role: empowered patients were expected to engage with various types of information and specific technologies in order to manage their own illnesses. Headlines such as Future patients will take care......), and domestication (Silverstone, 1989; Lie and S Keywords: patient empowerment; Patient 2.0; self-management; future healthcare system; change in healthcare practices; chronic/treated challenges...
Pascual Pérez Ballesta
Full Text Available The concept of population exposure as a direct indicator of the impact of pollution on public health is a consequence of the fact that the final aim of air quality measurements is the protection of the individuals' health. This article presents a picture of the exposure to air pollutants in different environments: industrial hygiene, indoor pollution and air quality legislation. The reduction of the health risk of the population to air pollution exposure opens new challenges when defining exposure indicators, control strategies and an effective assessment human exposure.
Tuberculosis (TB) continues to be a global health threat. BCG was developed as an attenuated live vaccine for tuberculosis control nearly a century ago. Despite being the most widely used vaccine in human history, BCG is not an ideal vaccine and has two major limitations: its poor efficacy against adult pulmonary TB and its disconcerting safety in immunocompromised individuals. A safer and more effective TB vaccine is urgently needed. This review article discusses current strategies to develop the next generation of TB vaccines to replace BCG. While some progresses have been made in the past decade, significant challenges lie ahead.
Madsen, Lene Møller; Winsløw, Carl
is the introduction of Geographical Information Systems (GIS). In this paper we explain and examine the theory of instrumental genesis in order to analyse the interplay between artefacts (such as GIS) and geographical knowledge. Based on a study of first year university students in Denmark we argue that this theory...... can be used to inform our understanding of the actual and potential roles of GIS in the education of geographers. Our conclusion is that there is a need to recognise GIS as an artefact interwoven with the professional development of becoming a geographer and to start researching the challenges...
Full Text Available Future Green Regional Aircraft (GRA will operate over airports located in the neighborhood of densely populated areas, with high frequency of takeoff/ landing events and, hence, strongly contribute to community noise and gaseous emissions. These issues currently limit further growth of traffic operated by regional airliners which, in the next future, will have to face even more stringent environmental normative worldwide and therefore re-designed to incorporate advanced active aerodynamic technologies. The new concept behind GRA is based on several mainstream technologies: airframe low-noise (LN, aerodynamic load control (LC and load alleviation (LA. These technologies integrate relevant concepts for hybrid and natural laminar flow (HLC/NLF wing, active control of wing movables and aeroelastic tailoring for LC/LA functions, passive means (micro-riblets for turbulent flow drag reduction, innovative gapless architectures (droop nose, morphing flap beside conventional high-lift devices (HLDs, active flow control through synthetic jets, low-noise solutions applied to HLDs (liners, fences, and to fuselage-mounted main and nose landing gears (bay/doors acoustic treatments, fairings, wheels hub cap. The paper deals with the technological readiness level (TRL assessment of the most promising technologies and overall integration in the new generation of GRA, as a highly optimized configuration able to meet requirements for FlighPath 2050.
Tamal Das; Suman Chakraborty
Biomicroﬂuidics is an active area of research at present, exploring the synergy of microﬂuidics with cellular and molecular biology, biotechnology, and biomedical engineering. The present article outlines the recent advancements in these areas, including the development of novel lab-on-a-chip based applications. Particular emphasis is given on the microﬂuidics-based handling of DNA, cells, and proteins, as well as fundamental microﬂuidic considerations for design of biomedical microdevices. Future directions of research on these topics are also discussed.
Southwell, Brian G.; Rupert, Douglas J.
Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to conventional broadcast and print advertising and ways in which it differs. We also highlight five key areas for future research: branded drug website influence on consumer knowledge and behavior, interactive features on branded drug websites, mobile viewing of branded websites and mobile advertisements, online promotion and non-US audiences, and social media and medication decisions. PMID:26927597
Rehani, M M
Radiation protection in medicine is becoming more and more important with increasing wider use of X-rays, documentation of effects besides the potential for long-term carcinogenic effects. With computed tomography (CT) likely to become sub-mSv in coming years, positron emission tomography (PET), single photon emission computed tomography (SPECT) and some of the nuclear medical examination will become focus of attraction as high-dose examinations, even though they are less-frequent ones. Clarity will be needed on radiation effects at levels of radiation doses encountered in a couple of CT scans and if effects are really cumulative. There is challenge to develop radiation metrics that can be used as easily as units of temperature and length and avoidance of multiple meaning of a single dose metric. Other challenges include development of biological indicators of radiation dose, transition from dose to a representative phantom to dose to individual patient, system for tracking of radiation exposure history of patient, avoidance of radiation-induced skin injury in patients and radiation cataract in staff, cutting down inappropriate referrals for radiological examinations, confidence building in patient and patient safety in radiotherapy.
Understanding the dynamics of circular or ring-like polymers has been a subject of investigation since the 1980s and is one which remains an area that is not fully understood. Part of the reason for this is the difficulty of making synthetic rings of sufficient size to establish the nature of the entanglement dynamics, if entanglements even exist in these materials. Furthermore, there is now strong evidence that small amounts of linear impurities can impact the dynamics. Hence, one of the major challenges to our understanding of ring dynamics is to make large molecular weight rings of sufficient purity that the dynamics of the rings themselves can be determined. In the present work the current state of understanding of the dynamics of rings is outlined and current work from our group of collaborators to make extremely large circular polymers using Echeverria Coli as a route to make pure rings (circular DNA) in sufficient quantity and size to determine the dynamics of these materials will be shown. First results of ring dynamics in dilute solution are presented and new results on concentrated and entangled solutions will be discussed. Remaining challenges will be elucidated. Partially supported by the John R. Bradford Endowment and the Paul Whitfield Horn Professorship at Texas Tech University.
Ivancic, William D.; Budinger, James M.; Staples, Edward J.; Abramovitz, Irwin; Courtois, Hector A.
NASA-Lewis' Space Electronics Div. supports ongoing research in advanced satellite communication architectures, onboard processing, and technology development. Recent studies indicate that meshed VSAT (very small aperture terminal) satellite communication networks using FDMA (frequency division multiple access) uplinks and TDMA (time division multiplexed) downlinks are required to meet future communication needs. One of the critical advancements in such a satellite communication network is the multichannel demultiplexer/demodulator (MCDD). The progress is described which was made in MCDD development using either acousto-optical, optical, or digital technologies.
Santiago, S. S.
A brief description of the NASA organization and how the CIO responsibilities are integrated into that organization followed by an introduction of the NASA ITS Program goals and objectives. An overview of the four major enterprises' cultures and how those cultures tie back to the Enterprises' missions. A description of the ITS challenges that exist stemming from the competing NASA Enterprises' requirements and how they have formed the basis of the NASA ITS Program. A talk will focus on policies and procedures and the technology being incorporated into the NASA infrastructure and how that technology ties back to the policies and procedures.
Keisch, B.; Auerbach, C.; Fainberg, A.; Fiarman, S.; Fishbone, L.G.; Higinbotham, W.A.; Lemley, J.R.; O' Brien, J.
The purpose of the task was to assess the effect of potential new technologies, nuclear and non-nuclear, on safeguards needs and non-proliferation policies, and to explore possible solutions to some of the problems envisaged. Eight subdivisions were considered: New Enrichment Technologies; Non-Aqueous Reprocessing Technologies; Fusion; Accelerator-Driven Reactor Systems; New Reactor Types; Heavy Water and Deuterium; Long-Term Storage of Spent Fuel; and Other Future Technologies (Non-Nuclear). For each of these subdivisions, a careful review of the current world-wide effort in the field provided a means of subjectively estimating the viability and qualitative probability of fruition of promising technologies. Technologies for which safeguards and non-proliferation requirements have been thoroughly considered by others were not restudied here (e.g., the Fast Breeder Reactor). The time scale considered was 5 to 40 years for possible initial demonstration although, in some cases, a somewhat optimistic viewpoint was embraced. Conventional nuclear-material safeguards are only part of the overall non-proliferation regime. Other aspects are international agreements, export controls on sensitive technologies, classification of information, intelligence gathering, and diplomatic initiatives. The focus here is on safeguards, export controls, and classification.
Nygaard, Ivan; Hansen, Ulrich Elmer
The strong focus in climate negotiations on the transfer and diffusion of technologies as ameans to mitigate and adapt to climate change has entailed various programs to promote the transfer and diffusion of climate technologies, including the Technology Needs Assessment project (TNA). Despite...... for the challenges in formulating plans of actions for technologies. If, due to a lack of conceptual clarity, it is not clear to countries whether the diffusion of a specific technology should be implemented by a project or by means of an enabling framework, the measures proposed in the action plans may...
Adam Youssef; Paul Mc Coubrie
Radiology has changed significantly in recent years. The volume of work has increased dramatically as has its complexity. Future radiologists need an adequate training and expertise in conventional practice as well as new techniques. This comes at a time when other stakeholders outside of radiology are voicing their own concerns. The rightly justified increasing focus on patient safety has placed even more emphasis on the demonstration of competent practice by all health care professionals. Credentialing has been put forward as a way to ensure a doctor is competent in specific areas. Credentialing may be an alien concept to many radiology trainees but moves are afoot in the United Kingdom to bring it to the forefront of its postgraduate medical training. Credentialing began in 20 th century North America where it was linked to the process of privileging. It subsequently garnered a strong patient safety focus and has become a part of the international healthcare agenda. Not everyone agrees with credentialing, it has many criticisms including the risk of speciality "turf wars" and the stifling of medical excellence to name just a couple. Is credentialing in radiology here to stay or will it pass by quietly? This paper reviews the global credentialing movement and discusses how this may impact on future radiology training, using the United Kingdom as its case example.
Lee, Dong-Hyun; Ha, Mun-Keun; Kim, Soo-Young; Shin, Sung-Chul
With the rate of worldwide LNG demand expected to grow faster than that of gas demand, most major oil companies are currently investing their resources to develop floating LNG-FLNG (i.e. LNG FSRU and LNG FPSO). The global Floating LNG (FLNG) market trend will be reviewed based on demand and supply chain relationships. Typical technical issues associated with FLNG design are categorized in terms of global performance evaluation. Although many proven technologies developed through LNG carrier and oil FPSO projects are available for FLNG design, we are still faced with several technical challenges to clear for successful FLNG projects. In this study, some of the challenges encountered during development of the floating LNG facility (i.e. LNG FPSO and FSRU) will be reviewed together with their investigated solution. At the same time, research of new LNG-related technologies such as combined containment system will be presented.
Footprint, concepts and tools from Life Cycle Assessment, and relevant elements from eco-efficiency theoretical frameworks. Often systemic approaches tend to be driven by completely rational models. However, our main contribution is to consider a more holistic approach that also includes socio......Though there is broad consensus that one of the solutions to the current environmental challenge will be based on the use of low-carbon technologies, and even though there is a big potential to turn to a more sustainable design and innovation, there are several elements that need to be taken...... as a study object and discusses the question: What are the main possibilities and challenges when designing low-carbon illumination technologies? To answer this question, we use a systemic approach including environmental, economic, energy and political issues using relevant concepts from the Ecological...
Full Text Available With the rate of worldwide LNG demand expected to grow faster than that of gas demand, most major oil companies are currently investing their resources to develop floating LNG-FLNG (i.e. LNG FSRU and LNG FPSO. The global Floating LNG (FLNG market trend will be reviewed based on demand and supply chain relationships. Typical technical issues associated with FLNG design are categorized in terms of global performance evaluation. Although many proven technologies developed through LNG carrier and oil FPSO projects are available for FLNG design, we are still faced with several technical challenges to clear for successful FLNG projects. In this study, some of the challenges encountered during development of the floating LNG facility (i.e. LNG FPSO and FSRU will be reviewed together with their investigated solution. At the same time, research of new LNG-related technologies such as combined containment system will be presented.
Tsuji, Issei (Idemitsu Kosan Co. Ltd., Tokyo, (Japan))
Non-woven fabrics which had been in the background as an auxiliary material is now on the surface as such disposable household merchandise as paper diapers, disposable pocket warmes and wet tissue, etc. rapidly get popular. The non-wovens show a large variety of performances according to the difference of the raw materials and the method of manufacture. What is important in the future is the technology of 'order-made' non-wovens, i.e., the complex texturing and the post-fabrication technology. This report describes on the following items: Definition and concept of non-woven fabrics. Market and applications. Production method (Wet process and dry process, bonding and entangling). Type and features (staple type, needle punched type, stitch bonded type, spun bond type, and wet type). Future trends. Reciprocal process. Melt-blown non-woven fabric. Spun-lace non-woven fabric. 5 refs., 3 figs., 4 tabs.
Full Text Available Defining and measuring organizational culture (OC is of paramount importance to organizations because a strong culture could potentially increase service quality and yield sustainable competitive advantages. However, such process could be challenging to managers because the scope of OC has been defined differently across disciplines and industries, which has led to the development of various scales for measuring OC. In addition, previously developed OC scales may also not be fully applicable in the hospitality and tourism context. Therefore, by highlighting the key factors affecting the business environment and the unique characteristics of hospitality industry, this paper aims to align the scope of OC closely with the industry and to put forth the need for a new OC scale that accurately responds to the context of the hospitality industry.
This anthology maps and analyses current trends within the area of family policy and outlines some possible challenges that the Nordic welfare states will soon be facing. Over several decades the Nordic welfare model has been characterised by the notion that children are not only the private...... such as New Public Management principles and increased focus on children’s positions and rights affect family policies in the Nordic countries? The authors, who come from all five Nordic countries, discuss the following topics: issues related to family demographics, children’s position in society...... responsibility of parents, but also a responsibility to be shared with society. Moreover, the Nordic welfare model goes hand-in-hand with the women’s movement by offering opportunities for women, as well as men, to also participate in education and employment. The question remains how more recent trends...
Full Text Available Fostered by and embedded in the general development of information and communications technology (ICT, the evolution of tsunami warning systems (TWS shows a significant development from seismic-centred to multi-sensor system architectures using additional sensors (e.g. tide gauges and buoys for the detection of tsunami waves in the ocean.
Currently, the beginning implementation of regional tsunami warning infrastructures indicates a new phase in the development of TWS. A new generation of TWS should not only be able to realise multi-sensor monitoring for tsunami detection. Moreover, these systems have to be capable to form a collaborative communication infrastructure of distributed tsunami warning systems in order to implement regional, ocean-wide monitoring and warning strategies.
In the context of the development of the German Indonesian Tsunami Early Warning System (GITEWS and in the EU-funded FP6 project Distant Early Warning System (DEWS, a service platform for both sensor integration and warning dissemination has been newly developed and demonstrated. In particular, standards of the Open Geospatial Consortium (OGC and the Organization for the Advancement of Structured Information Standards (OASIS have been successfully incorporated.
In the FP7 project Collaborative, Complex and Critical Decision-Support in Evolving Crises (TRIDEC, new developments in ICT (e.g. complex event processing (CEP and event-driven architecture (EDA are used to extend the existing platform to realise a component-based technology framework for building distributed tsunami warning systems.
Tauer, Loren W.
The economic impact of some future biological nitrogen fixation technologies are estimated using AGSIM, a dynamic, partial equilibrium, econometric model of the U.S. agricultural sector. Five separate scenarios were modeled: (1) legumes fix more nitrogen, (2) legumes fix more nitrogen with an increase in legumes yields of 10 percent, (3) nitrogen fertilization requirements on all crops are reduced 50 percent with no yield changes, (4) total elimination of nitrogen fertilization and (5) total ...
Webb, A G; Van de Moortele, P F
In this article we present our projections of future hardware developments on 7 T human MRI systems. These include compact cryogen-light magnets, improved gradient performance, integrated RF-receive and direct current shimming coil arrays, new RF technology with adaptive impedance matching, patient-specific specific absorption rate estimation and monitoring, and increased integration of physiological monitoring systems. Copyright © 2015 John Wiley & Sons, Ltd.
Sundin, George W; Castiblanco, Luisa F; Yuan, Xiaochen; Zeng, Quan; Yang, Ching-Hong
Plant diseases caused by bacterial pathogens place major constraints on crop production and cause significant annual losses on a global scale. The attainment of consistent effective management of these diseases can be extremely difficult, and management potential is often affected by grower reliance on highly disease-susceptible cultivars because of consumer preferences, and by environmental conditions favouring pathogen development. New and emerging bacterial disease problems (e.g. zebra chip of potato) and established problems in new geographical regions (e.g. bacterial canker of kiwifruit in New Zealand) grab the headlines, but the list of bacterial disease problems with few effective management options is long. The ever-increasing global human population requires the continued stable production of a safe food supply with greater yields because of the shrinking areas of arable land. One major facet in the maintenance of the sustainability of crop production systems with predictable yields involves the identification and deployment of sustainable disease management solutions for bacterial diseases. In addition, the identification of novel management tactics has also come to the fore because of the increasing evolution of resistance to existing bactericides. A number of central research foci, involving basic research to identify critical pathogen targets for control, novel methodologies and methods of delivery, are emerging that will provide a strong basis for bacterial disease management into the future. Near-term solutions are desperately needed. Are there replacement materials for existing bactericides that can provide effective disease management under field conditions? Experience should inform the future. With prior knowledge of bactericide resistance issues evolving in pathogens, how will this affect the deployment of newer compounds and biological controls? Knowledge is critical. A comprehensive understanding of bacterial pathosystems is required to not
Gromov, K.; Brix, Michael; Kallemose, T.
(currently 15,000). 85% of all procedures were performed on adult fractures and 15% on paediatric fractures. Proximal femur (33%), distal radius (15%) and malleolar fractures (12%) were the three most common primary adult fractures. Pain and discomfort from orthopaedic hardware, infection and failure......INTRODUCTION: The Danish Fracture Database (DFDB) was established in 2011 to establish nationwide prospective quality assessment of all fracture-related surgery. In this paper, we describe the DFDB's setup, present preliminary data from the first annual report and discuss its future potential...... are registered. Indication for reoperation is also recorded. The reoperation rate and the one-year mortality are the primary indicators of quality. RESULTS: Approximately 10,000 fracture-related surgical procedures were registered in the database at the time of presentation of the first annual DFDB report...
Chrimes, Adam F; Khoshmanesh, Khashayar; Stoddart, Paul R; Mitchell, Arnan; Kalantar-Zadeh, Kourosh
Raman microscopy systems are becoming increasingly widespread and accessible for characterising chemical species. Microfluidic systems are also progressively finding their way into real world applications. Therefore, it is anticipated that the integration of Raman systems with microfluidics will become increasingly attractive and practical. This review aims to provide an overview of Raman microscopy-microfluidics integrated systems for researchers who are actively interested in utilising these tools. The fundamental principles and application strengths of Raman microscopy are discussed in the context of microfluidics. Various configurations of microfluidics that incorporate Raman microscopy methods are presented, with applications highlighted. Data analysis methods are discussed, with a focus on assisting the interpretation of Raman-microfluidics data from complex samples. Finally, possible future directions of Raman-microfluidic systems are presented.
Full Text Available The term, inclusion, particularly in the educational setting, is still based on a deficit view. Perceptions of ‘dis’-ability create barriers to true inclusion and are often reinforced through higher education training programs. To promote inclusive values, acceptance of individual and cultural differences must be included in all curricula, not solely within special education. The future of a truly inclusive education relies on a cultural shift that supports and nurtures differences, and views success through a lens not focused on standardization but on diversity. The Index for Inclusion (The Index has been utilized worldwide to support schools, to remove perceived barriers and to establish increasingly inclusive school cultures and practices. The Index aids in the creation of a culture that is dedicated to identifying and reducing barriers to inclusion and increases the learning and participation for all students.
Nolan, Heather; Wang, Dongfang; Zwischenberger, Joseph B
There exists a growing demand for new technology that can take over the function of the human lung, from assisting an injured or recently transplanted lung to completely replacing the native organ. Many obstacles must be overcome to achieve the lofty goals and expectations of such a device. An artificial lung must be able to sustain the gas exchange requirements of a normal functioning lung. Pursuant to this purpose, the device must maintain appropriate blood pressure, decrease injury to blood cells and minimize clotting and immunologic response. Attachment methods vary, and ideally researchers want to find a way that minimizes bodily trauma, maximizes gas exchange and utilizes the inherent properties of the native lung. The currently proposed methods include the parallel, in-series and venous double-lumen cannula configurations. For the time being, current research focuses on the extracorporeal (i.e., outside the body) placement, but ultimate long-term goals look toward total implantation.
This introductory talk aims at setting pieces of context for the FPCA meeting and at reminding bits of history, for both electronic publishing and astronomy communication in a broader sense. While emphasizing the necessary complimentarity of media, it reflects on possible sociological limitations (among others at the level of evaluation committees) responsible for the fact that we still mainly produce electronic versions of documents printable or otherwise available on paper instead of practicing full electronic publishing for our verified knowledge. After introducing new publishing models and sketching possibly interfering new technologies, criticisms and questions from the community are echoed in a "Complaint of the Publishing Astronomer". A few comments are also made on evaluation criteria.
Data are the currency of science and assure the integrity of published research. As the ability to collect, analyze, and visualize data has grown beyond what could be included in a publication, and as the value of the data become more clear (or the lack of availability of data was criticized), publishers and the scientific community developed several solutions to enhance access to underlying data. Most leading journals now require authors to agree as a condition of submission that underlying data will be included or made available; indeed, publication is the key leverage point in exposing much scholarly data. Most journals allow PDF or other supplements and links to data sets hosted by authors or labs, or better, data repositories such as Dryad, and some have banned "data not shown" or any reference to unpublished work. Many of these solutions have proven problematic and recent studies have found that large fraction of data are undiscoverable even a few years after publication. The best solution has been dedicated domain repositories collectively supported by publishers, funders, and the scientific community and where deposition is required before or at the time of publication. These provide quality control and curation and facilitate reuse. However, expanding these beyond a few key repositories and developing standardized workflows and functionality among repositories and between them and publishers has been problematic. Addressing these and other data challenges requires collaborative efforts among funders, publishers, repositories, societies, and researchers. One example is the Coalition on Publishing Data in the the Earth and space sciences, where most major publishers and repositories have signed a joint statement of commitment (COPDESS.org), and are starting work to direct and link published data to domain repositories. Much work remains to be done. Major challenges include establishing data curation practices into the workflow of science from data collection
Jæger, Birgit; Peine, Alexander; Moors, Ellen
In this paper, we introduce the themes addressed and the approaches used in this special issue. We start by briefly discussing the state of the art in research and policy making related to science, technology and ageing. We argue that an important gap characterizes this state of the art: current ...... on the socio-material constitution of later life that implicates an important agenda for the future study of ageing and gerontechnology innovation....
Wohlgemuth, Roland; Plazl, Igor; Žnidaršič-Plazl, Polona
Despite the expanding presence of microscale technology in chemical synthesis and energy production as well as in biomedical devices and analytical and diagnostic tools, its potential in biocatalytic processes for pharmaceutical and fine chemicals, as well as related industries, has not yet been ......, and the future outlook for the implementation of these key green engineering methods and the role of supporting tools such as mathematical models to establish sustainable production processes are discussed....
Abedi, Ali; Wilkerson, DeLisa
This report presents various use case scenarios for wireless technology -including radio frequency (RF), optical, and acoustic- and studies requirements and boundary conditions in each scenario. The results of this study can be used to prioritize technology evaluation and development and in the long run help in development of a roadmap for future use of wireless technology. The presented scenarios cover the following application areas: (i) Space Vehicles (manned/unmanned), (ii) Satellites and Payloads, (iii) Surface Explorations, (iv) Ground Systems, and (v) Habitats. The requirement analysis covers two parallel set of conditions. The first set includes the environmental conditions such as temperature, radiation, noise/interference, wireless channel characteristics and accessibility. The second set of requirements are dictated by the application and may include parameters such as latency, throughput (effective data rate), error tolerance, and reliability. This report provides a comprehensive overview of all requirements from both perspectives and details their effects on wireless system reliability and network design. Application area examples are based on 2015 NASA Technology roadmap with specific focus on technology areas: TA 2.4, 3.3, 5.2, 5.5, 6.4, 7.4, and 10.4 sections that might benefit from wireless technology.
The work reported here was carried out for the Department of Energy's Office of Fossil Energy to identify and assess 15 to 20 major environmental issues likely to affect the implementation of fossil energy technologies between 1985 and 2000. The energy technologies specifically addressed are: oil recovery and processing; gas recovery and processing; coal liquefaction; coal gasification (surface); in situ coal gasification; direct coal combustion; advanced power systems; magnetohydrodynamics; surface oil shale retorting; and true and modified in situ oil shale retorting. Environmental analysis of these technologies included, in addition to the main processing steps, the complete fuel cycle from resource extraction to end use. The 16 environmental issues identified as those most likely for future regulatory actions and the main features of, and the possible regulatory actions associated with, each are as follows: disposal of solid waste from coal conversion and combustion technologies; water consumption by coal and oil shale conversion technologies; siting of coal conversion facilities; the carbon dioxide greenhouse effect; emission of polycyclic organic matter (POM); impacts of outer continental shelf (OCS) oil development; emission of trace elements; groundwater contamination; liquefied natural gas (LNG), safety and environmental factors; underground coal mining - health and safety; fugitive emissions from coal gasification and liquefaction - health and safety; boomtown effects; emission of fine particulates from coal, oil and oil shale technologies; emission of radioactivity from the mining and conversion of coal; emission of nitrogn oxides; and land disturbance from surface mining. (LTN)
V. Madhu Viswanatham
Full Text Available The expansion of networking infrastructure has provided a novel way to store and access resources in a reliable, convenient and affordable means of technology called the Cloud. The cloud has become so popular and established its dominance in many recent world innovations and has highly influenced the trend of the Business process Management with the advantage of shared resources. The ability to remain disaster tolerant, on-demand scalability, flexible deployment and cost effectiveness has made the future world technologies like Internet of Things, to determine the cloud as their data and processing center. However, along with the implementation of cloud based technologies, we must also address the issues involved in its realization. This paper is a review on the advancements, scopes and issues involved in realizing a secured cloud powered environments.
Hamelin, Lorie; Wesnæs, Marianne; Wenzel, Henrik
the volatile solids in the solid fraction. The biogas scenario involving the most efficient separation technology resulted in a dry matter separation efficiency of 87% and allowed a net reduction of the global warming potential of 40%, compared to the reference slurry management. This figure comprises......This consequential life cycle assessment study highlights the key environmental aspects of producing biogas from separated pig and cow slurry, a relatively new but probable scenario for future biogas production, as it avoids the reliance on constrained carbon cosubstrates. Three scenarios involving...... different slurry separation technologies have been assessed and compared to a business-as-usual reference slurry management scenario. The results show that the environmental benefits of such biogas production are highly dependent upon the efficiency of the separation technology used to concentrate...
Cancer patients often suffer from various distresses, including cognitive impairment. Cognitive impairment during and after cancer diagnosis and treatment are collectively called "Cancer-related cognitive impairment (CRCI)". The number of publications about cognitive impairment due to cancer therapy, especially chemotherapy, hormonal therapy, and radiotherapy, has been growing. Patients often worry not only about their disease condition and therapies, but also experience concerns regarding their memory, attention, and ability to concentrate. Even subtle CRCI can have a significant impact on social relationships, the ability to work, undergo treatment, accomplish meaningful goals, and the quality of life. Longitudinal studies of cancer patients indicated that up to 75% experience CRCI during treatment. Furthermore, CRCI may persist for many years following treatment. However, it is not well understood by most physicians and medical staff. CRCI can be mediated through increased inflammatory cytokines and hormonal changes. In addition, the biology of the cancer, stress, and attentional fatigue can also contribute to CRCI. Genetic factors and co-occurring symptoms may explain some of the inter-individual variability in CRCI. Researchers and patients are actively trying to identify effective interventional methods and useful coping strategies. Many patients are willing to discuss their disease condition and future treatment with medical staff and/or their families. Some patients also hope to discuss their end-of-life care. However, it is difficult to express their will after developing cognitive impairment. Advance care planning (ACP) can help in such situations. This process involves discussion between a patient, their family, and clinicians to clarify and reflect on values, treatment preferences, and goals to develop a shared understanding of how end-of-life care should proceed. The number of cancer patients with cognitive impairment has been increasing owing to the
Stewart, Emma; Kiliccote, Sila; McParland, Charles
The software that the utility industry currently uses may be insufficient to analyze the distribution grid as it rapidly modernizes to include active resources such as distributed generation, switch and voltage control, automation, and increasingly complex loads. Although planners and operators have traditionally viewed the distribution grid as a passive load, utilities and consultants increasingly need enhanced analysis that incorporates active distribution grid loads in order to ensure grid reliability. Numerous commercial and open-source tools are available for analyzing distribution grid systems. These tools vary in complexity from providing basic load-flow and capacity analysis under steady-state conditions to time-series analysis and even geographical representations of dynamic and transient events. The need for each type of analysis is not well understood in the industry, nor are the reasons that distribution analysis requires different techniques and tools both from those now available and from those used for transmission analysis. In addition, there is limited understanding of basic capability of the tools and how they should be practically applied to the evolving distribution system. The study reviews the features and state of the art capability of current tools, including usability and visualization, basic analysis functionality, advanced analysis including inverters, and renewable generation and load modeling. We also discuss the need for each type of distribution grid system analysis. In addition to reviewing basic functionality current models, we discuss dynamics and transient simulation in detail and draw conclusions about existing software?s ability to address the needs of the future distribution grid as well as the barriers to modernization of the distribution grid that are posed by the current state of software and model development. Among our conclusions are that accuracy, data transfer, and data processing abilities are key to future
Fletcher-Lartey, Stephanie M; Caprarelli, Graziella
The uptake and acceptance of Geographic Information Systems (GIS) technology has increased since the early 1990s and public health applications are rapidly expanding. In this paper, we summarize the common uses of GIS technology in the public health sector, emphasizing applications related to mapping and understanding of parasitic diseases. We also present some of the success stories, and discuss the challenges that still prevent a full scope application of GIS technology in the public health context. Geographical analysis has allowed researchers to interlink health, population and environmental data, thus enabling them to evaluate and quantify relationships between health-related variables and environmental risk factors at different geographical scales. The ability to access, share and utilize satellite and remote-sensing data has made possible even wider understanding of disease processes and of their links to the environment, an important consideration in the study of parasitic diseases. For example, disease prevention and control strategies resulting from investigations conducted in a GIS environment have been applied in many areas, particularly in Africa. However, there remain several challenges to a more widespread use of GIS technology, such as: limited access to GIS infrastructure, inadequate technical and analytical skills, and uneven data availability. Opportunities exist for international collaboration to address these limitations through knowledge sharing and governance.
Sparovek, Gerd; Berndes, Göran; Klug, Israel L F; Barretto, Alberto G O P
Brazilian agriculture covers about one-third of the land area and is expected to expand further. We assessed the compliance of present Brazilian agriculture with environmental legislation and identified challenges for agricultural development connected to this legislation. We found (i) minor illegal land use in protected areas under public administration, (ii) a large deficit in legal reserves and protected riparian zones on private farmland, and (iii) large areas of unprotected natural vegetation in regions experiencing agriculture expansion. Achieving full compliance with the environmental laws as they presently stand would require drastic changes in agricultural land use, where large agricultural areas are taken out of production and converted back to natural vegetation. The outcome of a full compliance with environmental legislation might not be satisfactory due to leakage, where pristine unprotected areas become converted to compensate for lost production as current agricultural areas are reconverted to protected natural vegetation. Realizing the desired protection of biodiversity and natural vegetation, while expanding agriculture to meet food and biofuel demand, may require a new approach to environmental protection. New legal and regulatory instruments and the establishment of alternative development models should be considered.
Full Text Available Mariam Siddiqui,1 Michael S Putman,2 Anisha B Dua,11Department of Rheumatology, 2Department of Internal Medicine, The University of Chicago Medical Center, Chicago, IL, USA Abstract: Adult-onset Still's disease (AOSD – a multi-systemic inflammatory condition characterized by high fevers, polyarthritis, an evanescent rash, and pharyngitis – has been a challenging condition to diagnose expediently and treat effectively. Questions remain regarding the underlying pathophysiology and etiology of AOSD. Pathognomonic diagnostic tests and reliable biomarkers remain undiscovered. Over the past decade, important progress has been made. Diagnostic criteria employing glycosylated ferritin have improved specificity. More important, novel biologic therapies have offered important clues to AOSD's underlying pathophysiology. Cytokine-specific biologic therapies have been instrumental in providing more effective treatment for disease refractory to conventional treatment. While IL-1 therapy has demonstrated efficacy in refractory disease, novel therapies targeting IL-6 and IL-18 show great promise and are currently under investigation. Keywords: adult-onset Still's disease, biomarkers, therapeutics
Glasius, Marianne; Goldstein, Allen H
Earth's atmosphere contains a multitude of organic compounds, which differ by orders of magnitude regarding fundamental properties such as volatility, reactivity, and propensity to form cloud droplets, affecting their impact on global climate and human health. Despite recent major research efforts and advances, there are still substantial gaps in understanding of atmospheric organic chemistry, hampering efforts to understand, model, and mitigate environmental problems such as aerosol formation in both polluted urban and more pristine regions. The analytical toolbox available for chemists to study atmospheric organic components has expanded considerably during the past decade, opening new windows into speciation, time resolution and detection of reactive and semivolatile compounds at low concentrations. This has provided unprecedented opportunities, but also unveiled new scientific challenges. Specific groundbreaking examples include the role of epoxides in aerosol formation especially from isoprene, the importance of highly oxidized, reactive organics in air-surface processes (whether atmosphere-biosphere exchange or aerosols), as well as the extent of interactions of anthropogenic and biogenic emissions and the resulting impact on atmospheric organic chemistry.
Seddon, Beatrice M., E-mail: firstname.lastname@example.org [London Sarcoma Service, Department of Oncology, University College Hospital, 1st Floor Central, 250 Euston Road, London, NW1 2PG (United Kingdom); Davda, Reena [London Sarcoma Service, Department of Oncology, University College Hospital, 1st Floor Central, 250 Euston Road, London, NW1 2PG (United Kingdom)
Uterine sarcomas are a group of rare tumours that provide considerable challenges in their treatment. Radiological diagnosis prior to hysterectomy is difficult, with the diagnosis frequently made post-operatively. Current staging systems have been unsatisfactory, although a new FIGO staging system specifically for uterine sarcomas has now been introduced, and may allow better grouping of patients according to expected prognosis. While the mainstay of treatment of early disease is a total abdominal hysterectomy, it is less clear whether routine oophorectomy or lymphadenectomy is necessary. Adjuvant pelvic radiotherapy may improve local tumour control in high risk patients, but is not associated with an overall survival benefit. Similarly there is no good evidence for the routine use of adjuvant chemotherapy. For advanced leiomyosarcoma, newer chemotherapy agents including gemcitabine and docetaxel, and trabectedin, offer some promise, while hormonal therapies appear to be more useful in endometrial stromal sarcoma. Novel targeted agents are now being introduced for sarcomas, and uterine sarcomas, and show some indications of activity. Non-pharmacological treatments, including surgical metastatectomy, radiofrequency ablation, and CyberKnife radiotherapy, are important additions to systemic therapy for advanced metastatic disease.
Dickherber, Anthony; Morris, Stephanie A; Grodzinski, Piotr
Nanotechnology offers an exceptional and unique opportunity for developing a new generation of tools addressing persistent challenges to progress in cancer research and clinical care. The National Cancer Institute (NCI) recognizes this potential, which is why it invests roughly $150 M per year in nanobiotechnology training, research and development. By exploiting the various capacities of nanomaterials, the range of nanoscale vectors and probes potentially available suggests much is possible for precisely investigating, manipulating, and targeting the mechanisms of cancer across the full spectrum of research and clinical care. NCI has played a key role among federal R&D agencies in recognizing early the value of nanobiotechnology in medicine and committing to its development as well as providing training support for new investigators in the field. These investments have allowed many in the research community to pursue breakthrough capabilities that have already yielded broad benefits. Presented here is an overview of how NCI has made these investments with some consideration of how it will continue to work with this research community to pursue paradigm-changing innovations that offer relief from the burdens of cancer.
Full Text Available There have been significant achievements inresearch at IMU as indicated by the increasing amountof external funds obtained, and number of publicationsand postgraduate students produced since it startedits research activities in the year 2000. However, it isa great challenge indeed to ensure sustainability ofour research, which is currently heavily dependent oninternal funding. There is a need to realign our strategiesto further enhance our competitiveness in securingexternal funding for research. In line with this, theInstitute for Research, Development and Innovation(IRDI was officially established on 18 September2012. The Institute will serve as a platform to supportall research activities at IMU. There are four Centresof Excellence based on the identified thrust areas underIRDI, namely 1 Centre for Bioactive Molecules andDrug Discovery; 2 Centre for Environmental andPopulation Health; 3 Centre for Cancer and StemCell Research, and 4 Centre for Health ProfessionalEducation Research. Major findings based on research inthese four thrust areas are reviewed in this paper. Withthe strategic planning and establishment of IRDI, it isour aspiration to bring research at IMU to a higher level.
Kolahi, Mahdi; Sakai, Tetsuro; Moriya, Kazuyuki; Makhdoum, Majid F.
Since the 1950s, there has been a continuous increase in the number and coverage of protected areas (PAs) in Iran, and in total 253 PAs have been declared that cover 10.12 % of the country's area. This paper reviews literature addressing Iran's PAs, examines what is known about them, highlights the challenges and lessons learned, and identifies areas where more research is needed. The PA system in Iran is criticized because of (1) shortages of manpower, equipment, and financial resources; (2) de jure PAs that are often implemented as de facto reserves; (3) lack of national biodiversity indicators and objective monitoring processes; and (4) limited public participation and conflict between people over PAs. To improve, Iran's PAs system needs to be realistically supported by policies and planning instruments. In addition, the implementation of active management to restore habitat, increase education and awareness, shift practices towards the guidelines of international organizations, build capacity, and improve management and co-management by local communities needs to occur.
Widiger, Thomas A; Krueger, Robert F
Provides an introduction to a special section of Personality Disorders: Theory, Research, and Treatment. The purpose of this special section is to provide a discussion of the current status, lessons learned, and future challenges for the classification of personality disorders.
Fueled by the development of advanced driver assistance system (ADAS), autonomous vehicles, and the proliferation of cameras and sensors, automotive is becoming a rich new domain for innovations in imaging technology. This paper presents an overview of ADAS, the important imaging and computer vision problems to solve for automotive, and examples of how some of these problems are solved, through which we highlight the challenges and opportunities in the automotive imaging space.
Verdejo-García, Antonio; Tirapu-Ustárroz, Javier
New lines of translational, interdisciplinary research are emerging among different fields of the neurosciences, which often point at clinical neuropsychology as the hinge discipline capable of linking the basic findings with their clinical implications and thereby endow them with some meaning for phenomenological experience. To establish the great lines of progress made in the fields of neuroscience and neuropsychology in recent years, so as to be able to foresee the strategic lines and priorities of neuroscience in the near future. To achieve this aim, the first step will be to identify the changes of paradigm that have taken place in the areas of neuroscience and psychology in the last two decades. The next step will be to propose new topics and fields of application that these changes in paradigm offer and demand from neuroscience. The false dichotomies of genes versus environment, mind versus brain, and reason versus emotion are considered, as are the new applications of neuropsychology to the understanding of psychopathological disorders, from the neurodegenerative to neurodevelopment, from 'dirty' drugs to cognitive and affective enhancers.
AUTHOR|(CDS)2108454; Zimmermann, Frank
Following the 2013 update of the European Strategy for Particle Physics, the international Future Circular Collider (FCC) study has been launched by CERN as host institute, to design an energy frontier hadron collider (FCC-hh) in a new 80-100 km tunnel with a centre-of-mass energy of about 100 TeV, an order of magnitude above the LHC's, as a long-term goal. The FCC study also includes the design of a 90-350 GeV high-luminosity lepton collider (FCC-ee) fitting the same tunnel, serving as Higgs, top and Z factory, as a potential intermediate step, as well as an electron-proton collider option (FCC-he). The physics cases for such machines will be assessed, concepts for experiments be worked out, and complete accelerator designs be developed in time for the next update of the European Strategy for Particle Physics by the end of 2018. Beside superconductor improvements and high-field magnet prototyping, the FCC R&D program includes the advancement of SRF cavities based on thin film coating, the development of ...
Hong, Seongjin; Giesy, John P.; Lee, Jung-Suk; Lee, Jong-Hyeon; Khim, Jong Seong
Effect-directed analysis (EDA) has become useful for identification of toxicant(s) that occur in mixtures in the environment, especially those that are causative agents of specific adverse effects. Here, we summarize and review EDA methodology including preparation of samples, biological analyses, fractionations, and instrumental analyses, highlighting key scientific advancements. A total of 63 documents since 1999 (Scopus search) including 46 research articles, 13 review papers, and 4 project descriptions, have been collected and reviewed in this study. At the early stage (1999-2010), most studies that applied EDA focused on organic extracts of freshwater and coastal contaminated sediments and wastewater. Toxic effects were often measured using cell-based bioassays ( in vitro) and the causative chemicals were identified by use of low resolution gas chromatography with mass selective detector (GCMSD). More recently (2010-present), EDA has been extended to various matrices such as biota, soil, crude oil, and suspended solids and techniques have been improved to include determination of bioavailability in vivo. In particular, methods for non-target screenings of organic chemicals in environmental samples using cutting-edge instrumentation such as time of flight-mass spectrometry (ToF-MS), Fourier transform-ion cyclotron resonance (FT-ICR), and Orbitrap mass spectrometer have been developed. This overview provides descriptions of recent improvements of EDA and suggests future research directions based on current understandings and limitations.
Quaglio, GianLuca; Goerens, Charles; Putoto, Giovanni; Rübig, Paul; Lafaye, Pierre; Karapiperis, Theodoros; Dario, Claudio; Delaunois, Paul; Zachariah, Rony
The Ebola virus epidemic has topped media and political agendas for months; several countries in west Africa have faced the worst Ebola epidemic in history. At the beginning of the disease outbreak, European Union (EU) policies were notably absent regarding how to respond to the crisis. Although the epidemic is now receding from public view, this crisis has undoubtedly changed the European public perception of Ebola virus disease, which is no longer regarded as a bizarre entity confined in some unknown corner in Africa. Policy makers and researchers in Europe now have an opportunity to consider the lessons learned. In this Personal View, we discuss the EU's response to the Ebola crisis in west Africa. Unfortunately, although ample resources and opportunities for humanitarian and medical action existed, the EU did not use them to promote a rapid and well coordinated response to the Ebola crisis. Lessons learned from this crisis should be used to improve the role of the EU in similar situations in the future, ensuring that European aid can be effectively deployed to set up an improved emergency response system, and supporting the establishment of sustainable health-care services in west Africa.
Full Text Available The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. Inspired by the symbiotic origin of mitochondria and by the cell’s capacity to transfer these organelles to damaged neighbors, many researchers have developed procedures to artificially transfer mitochondria from one cell to another. The techniques currently in use today range from simple coincubations of isolated mitochondria and recipient cells to the use of physical approaches to induce integration. These methods mimic natural mitochondria transfer. In order to use mitochondrial transfer in medicine, we must answer key questions about how to replicate aspects of natural transport processes to improve current artificial transfer methods. Another priority is to determine the optimum quantity and cell/tissue source of the mitochondria in order to induce cell reprogramming or tissue repair, in both in vitro and in vivo applications. Additionally, it is important that the field explores how artificial mitochondria transfer techniques can be used to treat different diseases and how to navigate the ethical issues in such procedures. Without a doubt, mitochondria are more than mere cell power plants, as we continue to discover their potential to be used in medicine.
Full Text Available Motivation: The motivation of this overview is to present the state of the art of Job Demands–Resources (JD–R model whilst integrating the various contributions to the special issue.Research purpose: To provide an overview of the JD–R model, which incorporates many possible working conditions and focuses on both negative and positive indicators of employee well-being. Moreover, the studies of the special issue were introduced.Research design: Qualitative and quantitative studies on the JD–R model were reviewed to enlighten the health and motivational processes suggested by the model.Main findings: Next to the confirmation of the two suggested processes of the JD–R model, the studies of the special issue showed that the model can be used to predict work-place bullying, incidences of upper respiratory track infection, work-based identity, and early retirement intentions. Moreover, whilst psychological safety climate could be considered as a hypothetical precursor of job demands and resources, compassion satisfaction moderated the health process of the model.Contribution/value-add: The findings of previous studies and the studies of the special issue were integrated in the JD–R model that can be used to predict well-being and performance at work. New avenues for future research were suggested.Practical/managerial implications: The JD–R model is a framework that can be used for organisations to improve employee health and motivation, whilst simultaneously improving various organisational outcomes.
Morales, Javier O; Fathe, Kristin R; Brunaugh, Ashlee; Ferrati, Silvia; Li, Song; Montenegro-Nicolini, Miguel; Mousavikhamene, Zeynab; McConville, Jason T; Prausnitz, Mark R; Smyth, Hugh D C
Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g., acidic stomach pH, digestive enzymes, and limited permeation through the gastrointestinal tract), several alternative routes of administration have been investigated to enable sufficient drug absorption into systemic circulation. This review describes the buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers. While all these routes avoid transit through the gastrointestinal tract, each has its own strengths and weaknesses that may be optimal for specific classes of compounds. Buccal and sublingual delivery enable rapid drug uptake through a relatively permeable barrier but are limited by small epithelial surface area, stratified epithelia, and the practical complexities of maintaining a drug delivery system in the mouth. Pulmonary delivery accesses the highly permeable and large surface area of the alveolar epithelium but must overcome the complexities of safe and effective delivery to the alveoli deep in the lung. Transdermal delivery offers convenient access to the body for extended-release delivery via the skin surface but requires the use of novel devices and formulations to overcome the skin's formidable stratum corneum barrier. New technologies and strategies advanced to overcome these challenges are reviewed, and critical views in future developments of each route are given.
Merican, M I; Rohaizat, Y; Haniza, S
The Malaysian health care system is a success story among countries of equivalent socio-economic status. However there are numerous challenges faced by the nation, which create the need for changes and reform. There is rising consumer demands and expectations for high technology and high cost medical care due to improved standards of living, changing disease patterns and demographic changes, inadequate integration of health services, maldistribution of resources and the threats as well as opportunities of globalisation and liberalisation. The changes in health policy, priorities and planning for the country are guided by the country's development policies, objectives and the challenges of Vision 2020, Vision for Health and the goals of the health system in ensuring universal access, improving equity and efficiency and the quality of life of the population. The essential services in the health system of the future are information and education of individuals to empower support for the wellness paradigm. There is also a need to restructure the national health care financing and the health care delivery system. The present roles and responsibilities of MOH also need to be reviewed.
Ali, Eaqub; Sultana, Sharmin; Hamid, Sharifah Bee Abd; Hossain, Motalib; Yehya, Wageeh A; Kader, Abdul; Bhargava, Suresh K
Gelatin is a highly purified animal protein of pig, cow, and fish origins and is extensively used in food, pharmaceuticals, and personal care products. However, the acceptability of gelatin products greatly depends on the animal sources of the gelatin. Porcine and bovine gelatins have attractive features but limited acceptance because of religious prohibitions and potential zoonotic threats, whereas fish gelatin is welcomed in all religions and cultures. Thus, source authentication is a must for gelatin products but it is greatly challenging due to the breakdown of both protein and DNA biomarkers in processed gelatins. Therefore, several methods have been proposed for gelatin identification, but a comprehensive and systematic document that includes all of the techniques does not exist. This up-to-date review addresses this research gap and presents, in an accessible format, the major gelatin source authentication techniques, which are primarily nucleic acid and protein based. Instead of presenting these methods in paragraph form which needs much attention in reading, the major methods are schematically depicted, and their comparative features are tabulated. Future technologies are forecasted, and challenges are outlined. Overall, this review paper has the merit to serve as a reference guide for the production and application of gelatin in academia and industry and will act as a platform for the development of improved methods for gelatin authentication.
Mogensen, Jeppe; Jørgensen, Poul-Erik; Poulsen, Søren Bolvig
Concerned with the overall challenges of implementing design innovations, this paper relates to the specific case of applying smart textiles in future hospital interiors. The methodological approach is inspired by design thinking and implementation processes, and through the scope of a developed...... strategic framework, the implementation challenges will be discussed from a holistic integrative design perspective. With this explorative initiative, our aim is to present specific approaches to progress the design innovation of smart textiles, and the implementation climate of future hospitals....
Full Text Available Despite the UN’s adoption of a new economic and social right in 2010 - the Right to safe drinking water and sanitation - the deficit of fresh water is becoming increasingly severe and large-scale.The mounting water crisis and its geography make it clear that without resolute counteraction, many societies’ adaptive capacities within the coming decades will be overstretched.The scale and the global nature of the water crisis demand a new level of statesmanship, of vision and of international action. To master successfully the threats of water crisis, not only its effects, but essentially its underlying causes must be addressed by implementing structural changes in our water policies and economies. This requires a coherent strategy in which the economic, social, water and environmental aspects of policy must be properly coordinated.The world needs a standalone comprehensive “water goal” in the post-2015 development agenda, based on principles of equity, solidarity, recognition of the limits of our planet and rights approach, and linking development and environment in analyses and in governance policies. Such a goal would address the three interdependent dimensions of water: Water, Sanitation and Hygiene, Water Resources Management and Wastewater Management and Water Quality.Scientific understanding of water risks and worldwide evidence clearly define the challenges to be addressed and provide a sound basis for policy; the resources required could be made available if the water agenda is given sufficient priority; and the benefits and opportunities of early action are undeniable. In fact, the moral, scientific and practical imperatives for action are established.
Alevizaki, M; Stratakis, C A
Several important advances have been made over the last 2 years, since the last international workshop on multiple endocrine neoplasias (MENs) that was held in Marseilles, France (MEN2006). The series of articles that are included in this issue summarize the most important of these advances as they were presented in Delphi, Greece, during the 11th International Workshop on MENs, September 25-27, 2008 (MEN2008). This editorial summarizes some of these advances: the identification of the AIP, and the PDE11A and PDE8B genes by genome-wide association (GWA) studies as predisposing genes for pituitary and adrenal tumours, respectively, the discovery of p27 mutations in a new form of MEN similar to MEN type 1 (MEN 1) that is now known as MEN 4, the molecular investigations of Carney triad (CT), a disorder that associates paragangliomas (PGLs), gastrointestinal stromal tumour (GISTs), and pulmonary chondromas (PCH) with pheochromocytomas and adrenocortical adenomas and other lesions, and the molecular elucidation of the association of GISTs with paragangliomas (Carney-Stratakis syndrome) that is now known to be because of SDHB, SDHC, and SDHD mutations. Molecular investigations in Carney complex (another MEN also described by Dr. Carney, who during the meeting, along with Dr. Charles E. ('Gene') Jackson was honoured for his life-long and many contributions to the field) have also revealed the role of cyclic AMP signalling in tumorigenesis. As our knowledge of the molecular causes of MENs increases, the challenge is to translate these discoveries in better treatments for our patients. Indeed, new advances in the preventive diagnosis and molecular treatment of MEN 1 and MEN 2, respectively, continued unabated, and an update on this front was also presented at MEN2008 and is included in this issue.
Boysen, Philip G.; Daste, Laurie; Northern, Theresa
Background: Demographics are changing on a global scale. In the United States, an aging population continues to work, either by preference or because of insufficient resources to retire. Of even greater importance, a younger generation, referred to as the Millennial Generation, will soon predominate in the workforce and even now accounts for nearly 100% of resident physicians. By the year 2020, there will be 5 generations in the workplace. Methods: This paper defines and details the characteristics of the 5 generations and examines how the vision, attitudes, values, and expectations of the most recent generations will reshape the workforce and graduate medical education. Results: The need for change is imminent to educate the next generation of physicians. Among the changes necessary to adapt to the multigenerational challenges ahead are adopting mobile devices as preferred communication tools; using social networking sites to recruit residents; adding games, simulations, and interactive videos to the curriculum to engage students; breaking down departmental silos and forming learning teams that come from different specialties; developing benchmarks and milestones to measure progress; extending the social learning ecosystem beyond the resident years; embracing diversity as the norm for both practice and learning; and providing both coaching and mentoring. Conclusion: For decades, resident physicians have shown commitment, tenacity, and selflessness while shouldering the dual responsibility of patient care and the pursuit of their own education and skills development. Resident engagement has been shown to drive change in undergraduate medical education and in the learning and performance of their teachers. The latter is evidence of reverse mentoring that will be a major factor for improvement in this digital age. We have only to embrace this opportunity to the benefit of our patients, our learners, and ourselves. PMID:27046415
The global energy context pleads in favour of a sustainable development of nuclear energy since the demand for energy will likely increase, whereas resources will tend to get scarcer and the prospect of global warming will drive down the consumption of fossil fuel. In this context, nuclear power has the worldwide potential to curtail the dependence on fossil fuels and thereby to reduce the amount of greenhouse gas emissions while promoting energy independence. How we deal with nuclear radioactive waste is crucial in this context. In France, the public's concern regarding the long-term waste management made the French Governments to prepare and pass the 1991 and 2006 Acts, requesting in particular the study of applicable solutions for still minimizing the quantity and the hazardousness of final waste. This necessitates High Active Long Life element (such as the Minor Actinides MA) recycling, since the results of fuel cycle R&D could significantly change the challenges for the storage of nuclear waste. HALL recycling can reduce the heat load and the half-life of most of the waste to be buried to a couple of hundred years, overcoming the concerns of the public related to the long-life of the waste and thus aiding the "burying approach" in securing a "broadly agreed political consensus" of waste disposal in a geological repository. This paper presents an overview of the recent R and D results obtained at the CEA Atalante facility on innovative actinide partitioning hydrometallurgical processes. For americium and curium partitioning, these results concern improvements and possible simplifications of the Diamex-Sanex process, whose technical feasibility was already demonstrated in 2005. Results on the first tests of the Ganex process (grouped actinide separation for homogeneous recycling) are also discussed. In the coming years, next steps will involve both better in-depth understanding of the basis of these actinide partitioning processes and, for the new promising
-resistant depression continues to challenge mental health care providers, and further relevant research involving newer drugs is warranted to improve the quality of life of patients with the disorder.Keywords: treatment-resistant depression, antidepressants, biomarkers, therapeutic options, somatic therapies
Stone, J. R.
There are many fascinating processes in the Universe which we observe in more and more in detail thanks to increasingly sophisticated technology. One of the most interesting phenomena is the life cycle of stars, their birth, evolution and death. If the stars are massive enough, they end their lives in the core-collapse supernova explosion, the one of the most violent events in the Universe. As the result, the densest objects in the Universe, neutron stars and/or black holes are created. Naturally, the physical basis of these events should be understood in line with observation. The current status of our knowledge of processes in the life of stars is far from adequate for their true understanding. We show that although many models have been constructed their detailed ability to describe observations is limited or non-existent. Furthermore the general failure of all models means that we cannot tell which are heading in the right direction. A possible way forward in modeling of high-density matter is outlined, exemplified by the quark-meson-coupling model (QMC). This model has a natural explanation for the saturation of nuclear forces and depends on very few adjustable parameters, strongly constrained by the underlying physics. Latest QMC results for compact objects and finite nuclei are presented.
Stone J. R.
Full Text Available There are many fascinating processes in the Universe which we observe in more and more in detail thanks to increasingly sophisticated technology. One of the most interesting phenomena is the life cycle of stars, their birth, evolution and death. If the stars are massive enough, they end their lives in the core-collapse supernova explosion, the one of the most violent events in the Universe. As the result, the densest objects in the Universe, neutron stars and/or black holes are created. Naturally, the physical basis of these events should be understood in line with observation. The current status of our knowledge of processes in the life of stars is far from adequate for their true understanding. We show that although many models have been constructed their detailed ability to describe observations is limited or non-existent. Furthermore the general failure of all models means that we cannot tell which are heading in the right direction. A possible way forward in modeling of high-density matter is outlined, exemplified by the quark-meson-coupling model (QMC. This model has a natural explanation for the saturation of nuclear forces and depends on very few adjustable parameters, strongly constrained by the underlying physics. Latest QMC results for compact objects and finite nuclei are presented.
Garcia, P. J. V.; Glindemann, A.; Henning, Th.; Malbet, F.
The last quarter of the 20th century witnessed the rebirth and maturing of optical interferometry and associated technologies. Major successes spanning from direct detection of stellar pulsations to imaging in the optical were achieved with test-bed systems, some of which have now evolved to facilities open to the astronomical community. The intense activity and rapid growth of this field are a clear sign that interferometry will be a major observational tool in this century both from ground and space. The VLTI is the largest ground-based interferometric facility combining four 8.2-m telescopes with up to eight 1.8-m telescopes. This facility is the first opened on a shared risk basis in 2002, a milestone for the astronomical community. The combination of enhanced sensitivity and common user support bring into grasp a vastly unexplored astrophysical territory. This book presents state of the art optical interferometry in astrophysics. We emphasise new VLTI users by including tutorials in optical interferometry theory and practice, and related instrumentation, as well as reviews in stellar formation and evolution, and extragalactic science. Link: http://www.wkap.nl/prod/b/1-4020-1518-6
Ana Castillo-Díaz, Ph. D.
Full Text Available In an increasingly competitive environment in which Internet occupies a prominent place, transferring a brand from the offline to the online environment has become a vital issue for companies. Usability and accessibility have become crucial to enable adequate online brand communication. Ensuring websites are usable and accessible will facilitate web navigation, will improve the company’s image, and will favour loyalty towards the brand.This article presents the results of an investigation measuring the extent to what small and medium enterprises (SMEs employ usability and accessibility as supporting pillars of brand in the online environment to communicate with their audiences. The results indicate that usability is in fact taken into account by SMEs, but it is seen more as a technological element than as a promotion tool for the brand. Accessibility, on the other hand, is of secondary concern in the design of websites analysed, since they are not certified by any standard and are not fully accessible. Thus, it can be argued that the concern to transmit the brand online is incipient but, currently, SMEs do not take advantage of all the potential offered by the Web.
Full Text Available This account will give an overview and evaluation of the current advances in mass spectrometry (MS-based proteomics platforms and technology. A general review of some background information concerning the application of these methods in the characterization of molecular sizes and related protein expression profiles associated with different types of cells under varied experimental conditions will be presented. It is intended to provide a concise and succinct overview to those clinical researchers first exposed to this foremost powerful methodology in modern life sciences of postgenomic era. Proteomic characterization using highly sophisticated and expensive instrumentation of MS has been used to characterize biological samples of complex protein mixtures with vastly different protein structure and composition. These systems are then used to highlight the versatility and potential of the MS-based proteomic strategies for facilitating protein expression analysis of various disease-related organisms or tissues of interest. Major MS-based strategies reviewed herein include (1 matrix-assisted laser desorption ionization-MS and electron-spray ionization proteomics; (2 one-dimensional or two-dimensional gel-based proteomics; (3 gel-free shotgun proteomics in conjunction with liquid chromatography/tandem MS; (4 Multiple reaction monitoring coupled tandem MS quantitative proteomics and; (5 Phosphoproteomics based on immobilized metal affinity chromatography and liquid chromatography-MS/MS.
Scientific and technological advances in our understanding of the nature and consequences of human genetic variation are now allowing genetic determinants of susceptibility to common multifactorial diseases to be defined, as well as our individual response to therapy. I review how genome-wide association studies are robustly identifying new disease susceptibility loci, providing insights into disease pathogenesis and potential targets for drug therapy. Some of the remarkable advances being made using current genetic approaches in Crohn's disease, coronary artery disease and atrial fibrillation are described, together with examples from malaria, HIV/AIDS, asthma, prostate cancer and venous thrombosis which illustrate important principles underpinning this field of research. The limitations of current approaches are also noted, highlighting how much of the genetic risk remains unexplained and resolving specific functional variants difficult. There is a need to more clearly understand the significance of rare variants and structural genomic variation in common disease, as well as epigenetic mechanisms. Specific examples from pharmacogenomics are described including warfarin dosage and prediction of abacavir hypersensitivity that illustrate how in some cases such knowledge is already impacting on clinical practice, while in others prospective evaluation of clinical utility and cost-effectiveness is required to define opportunities for personalized medicine. There is also a need for a broader debate about the ethical implications of current advances in genetics for medicine and society. PMID:19737788
Introduction: - Colliders constructed and operated - Future High Energy Colliders under Study - Superconducting Phases and Applications - Possible Choices among SC Materials Superconducting Magnets and the Future - Advances in SC Magnets for Accelerators - Nb3Sn for realizing Higher Field - NbTi to Nb3Sn for realizing High Field (> 10 T) - HL-LHC as a critical milestone for the Future of Acc. Magnet Technology - Nb3Sn Superconducting Magnets (> 11 T)and MgB2 SC Links for HL-LHC - HL-LHC, 11T Dipole Magnet - Nb3Sn Quadrupole (MQXF) at IR - Future Circular Collider Study - Conductor development (1998-2008) - Nb3Sn conductor program - 16 T Dipole Options and R&D sharing - Design Study and Develoment for SppC in China - High-Field Superconductor and Magnets - HTS Block Coil R&D for 20 T - Canted Cosine Theta (CCT) Coil suitable with Brittle HTS Conductor - A topic at KEK: S-KEKB IRQs just integrated w/ BELLE-II ! Superconducting RF and the Future - Superconducting Phases and Applications - Poss...
Full Text Available ABSTRACTThis article aims to consider some relevant challenges to the provision of "new prevention technologies" in health services in a scenario where the "advances" in the global response to AIDS control are visible. We take as material for analysis the information currently available on the HIV post-exposure prophylaxis (PEP and pre-exposure prophylaxis (PrEP, treatment as prevention (TASP and over the counter. The methodology consisted of the survey and analysis of the Biblioteca Virtual em Saúde (BVS: MEDLINE, LILACS, WHOLIS, PAHO, SciELO articles that addressed the issue of HIV prevention and care in the context of so-called new prevention technologies. The results of the studies show that there is assistance on the ground of clinics for the treatment of disease responses, but there are several challenges related to the sphere of prevention. The articles list some challenges regarding to management, organization of services and the attention given by health professionals to users. The current context shows evidence of the effectiveness of antiretroviral therapy in reducing the risk of HIV transmission, but the challenges for the provision of preventive technologies in health services permeate health professionals and users in their individual dimensions and health services in organizational and structural dimension. Interventions should be made available in a context of community mobilization; there should be no pressure on people to make HIV testing, antiretroviral treatment or for prevention. In the management is responsible for the training of health professionals to inform, clarify and make available to users, partners and family information about the new antiretroviral use strategies.
Maksud, Ivia; Fernandes, Nilo Martinez; Filgueiras, Sandra Lucia
This article aims to consider some relevant challenges to the provision of "new prevention technologies" in health services in a scenario where the "advances" in the global response to AIDS control are visible. We take as material for analysis the information currently available on the HIV post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP), treatment as prevention (TASP) and over the counter. The methodology consisted of the survey and analysis of the Biblioteca Virtual em Saúde (BVS: MEDLINE, LILACS, WHOLIS, PAHO, SciELO) articles that addressed the issue of HIV prevention and care in the context of so-called new prevention technologies. The results of the studies show that there is assistance on the ground of clinics for the treatment of disease responses, but there are several challenges related to the sphere of prevention. The articles list some challenges regarding to management, organization of services and the attention given by health professionals to users. The current context shows evidence of the effectiveness of antiretroviral therapy in reducing the risk of HIV transmission, but the challenges for the provision of preventive technologies in health services permeate health professionals and users in their individual dimensions and health services in organizational and structural dimension. Interventions should be made available in a context of community mobilization; there should be no pressure on people to make HIV testing, antiretroviral treatment or for prevention. In the management is responsible for the training of health professionals to inform, clarify and make available to users, partners and family information about the new antiretroviral use strategies.
Martin, Shannon K; Farnan, Jeanne M; Arora, Vineet M
Changes in the clinical learning environment under resident duty hours restrictions have introduced a number of challenges on today's wards. Additionally, the current group of medical trainees is largely represented by the Millennial Generation, a generation characterized by an affinity for technology, interaction, and group-based learning. Special attention must be paid to take into account the learning needs of a generation that has only ever known life with duty hours. A mnemonic for strategies to augment teaching rounds for hospitalists was created using an approach that considers time limitations due to duty hours as well as the preferences of Millennial learners. These strategies to enhance learning during teaching rounds are Flipping the Wards, Using Documentation to Teach, Technology-Enabled Teaching, Using Guerilla Teaching Tactics, Rainy Day Teaching, and Embedding Teaching Moments into Rounds (FUTURE). Hospitalists serving as teaching attendings should consider these possible strategies as ways to enhance teaching in the post-duty hours era. These techniques appeal to the preferences of today's learners in an environment often limited by time constraints. Hospitalists are well positioned to champion innovative approaches to teaching in a dynamic and evolving clinical learning environment. © 2013 Society of Hospital Medicine.
Full Text Available Functional gastrointestinal disorders (FGIDs are a common problem in children. These disorders in children are classified into the following categories according to the ROME III classification: Functional Dyspepsia, Irritable bowel syndrome (IBS, Abdominal Migraines, Childhood Functional abdominal pain (FAP, Childhood functional abdominal pain syndrome and functional constipation. FGIDs are diagnosed based on history and normal physical examination provided that there is no evidence of underlying disease such as anatomical abnormalities, infectious, inflammatory and malignancies. This group of poorly defined diseases represent a huge treatment challenge to the specialist, because, until now there is no therapy that has been effective in improving the symptoms. FGIDs also cause deep family problems as the disease interrupts their routine and positive response to treatment is rarely seen. On the other hand there is no objective document of the disease neither endoscopic, radiologic nor pathologic. Therapeutic strategies of FGIDs are: education and parent's assurance, detection and modifying physical and psychological stress, dietary intervention, pharmacological treatment, psychotherapy and other complementary medical treatments. Some foods may trigger the illness such as coffee, fatty foods and spicy foods, therefore they should be avoided. Lactose-free diet cannot improve symptoms of FGIDs, except in children with lactose intolerance. The beneficial effect of fiber supplement in children with FGIDs remains unknown but it has been useful in adults with IBS. Probiotics have potential efficacy in treating IBS but the efficacy in children with FGIDs remains uncertain and needs to be further studied. In patients with severe symptoms, pharmacological agents can be effective. These drugs include Antacids, Prokinetics, Anticholinergic, Tricyclic antidepressants (TCAS and Serotonergic agents (Agonists and anti agonists. Psychotherapy in FAP and IBS is
Zeigler, Robert S; Mohanty, Samarendu
The success of the first Green Revolution in the form of abundant food supplies and low prices over the past two decades has diverted the world's attention from agriculture to other pressing issues. This has resulted in lower support for the agricultural research work primarily undertaken by the 15 research centers of the Consultative Group on International Agricultural Research (CGIAR). The total support in real dollars for most of the last three decades has been more or less flat although the number of centers increased from 4 to 15. However, since 2000, the funding situation has improved for the CGIAR centers, with almost all the increase coming from grants earmarked for specific research projects. Even for some centers such as the International Rice Research Institute (IRRI), the downward trend continued as late as 2006 with the budget in real dollars reaching the 1978 level of support. The recent food crisis has renewed the call for a second Green Revolution by revitalizing yield growth to feed the world in the face of growing population and a shrinking land base for agricultural use. The slowdown in yield growth because of decades of neglect in agricultural research and infrastructure development has been identified as the underlying reason for the recent food crisis. For the second Green Revolution to be successful, the CGIAR centers will have to play a complex role by expanding productivity in a sustainable manner with fewer resources. Thus, it is crucial to examine the current structure of support for the CGIAR centers and identify the challenges ahead in terms of source and end use of funds for the success of the second Green Revolution. The objective of this paper is to provide a historical perspective on the support to the CGIAR centers and to examine the current status of funding, in particular, the role of project-specific grants in rebuilding capacity of these centers. The paper will also discuss the nature of the support (unrestricted vs. project
, entrepreneurial life with training courses, education programs. At the University of Debrecen, the Institute of Accounting and Finance is faced with these educational challenges, such as introduction of SAP, and IFRS into the BA and MA education, and by using these systems to support managerial decision-making process and the management accounting. The purpose of this research is to examine how can the education reflect to the worldwide changes, and what is the mainstream in the accounting education nowadays. In order that the leaders of the businesses can make quick and appropriate economic decisions, it is essential in this intensively changing world that an enterprise should have a well-functioning accounting system based on up-to-date information. and that the university can teach new, practical knowledge.
García-Ruiz, José M.; Nadal-Romero, Estela; Lana-Renault, Noemí; Beguería, Santiago
Intense erosion processes are widespread in the Mediterranean region, and include sheet wash erosion, rilling, gullying, shallow landsliding, and the development of large and active badlands in both subhumid and semi-arid areas. This review analyses the main environmental and human features related to soil erosion processes, and the main factors that explain the extreme variability of factors influencing soil erosion, particularly recent land use changes. The importance of erosion in the Mediterranean is related to the long history of human activity in a region characterized by low levels of annual precipitation, the occurrence of intense rainstorms and long-lasting droughts, high evapotranspiration, the presence of steep slopes and the occurrence of recent tectonic activity, together with the recurrent use of fire, overgrazing and farming. These factors have resulted in a complex landscape in which intensification and abandonment, wealth and poverty can co-exist. The changing conditions of national and international markets and the evolution of population pressure are now the main drivers explaining land use changes, including farmland abandonment in mountain areas, the expansion of some subsidized crops to marginal lands, and the development of new terraces affected by landslides and intense soil erosion during extreme rainstorm events. The occurrence of human-related forest fires affecting thousands of hectares each year is a significant problem in both the northern and southern areas of the Mediterranean basin. Here, we highlight the rise of new scientific challenges in controlling the negative consequences of soil erosion in the Mediterranean region: 1) to reduce the effects and extent of forest fires, and restructure the spatial organization of abandoned landscapes; 2) to provide guidance for making the EU agricultural policy more adapted to the complexity and fragility of Mediterranean environments; 3) to develop field methods and models to improve the
Larsen, Hans; Soenderberg Petersen, L. (eds.)
Fossil fuels provide about 80% of the global energy demand, and this will continue to be the situation for decades to come. In the European Community we are facing two major energy challenges. The first is sustainability, and the second is security of supply, since Europe is becoming more dependent on imported fuels. These challenges are the starting point for the present Risoe Energy Report 6. It gives an overview of the energy scene together with trends and emerging energy technologies. The report presents status and trends for energy technologies seen from a Danish and European perspective from three points of view: security of supply, climate change and industrial perspectives. The report addresses energy supply technologies, efficiency improvements and transport. The report is volume 6 in a series of reports covering energy issues at global, regional and national levels. The individual chapters of the report have been written by staff members from the Technical University of Denmark and Risoe National Laboratory together with leading Danish and international experts. The report is based on the latest research results from Risoe National Laboratory, Technical University of Denmark, together with available internationally recognized scientific material, and is fully referenced and refereed by renowned experts. Information on current developments is taken from the most up-to-date and authoritative sources available. Our target groups are colleagues, collaborating partners, customers, funding organizations, the Danish government and international organizations including the European Union, the International Energy Agency and the United Nations. (au)
Mukomolov, Sergey; Trifonova, Galina; Levakova, Irina; Bolsun, Daria; Krivanogova, Eugenia
seen in the near future that will require urgent preventive and therapeutic measures.
Full Text Available Aim of study: Bamboo, the fastest growing and high yielding perennial plant of the world has more than 1500 species and 1500 versatile socio-economic uses and ecological services. Ethiopia has two indigenous bamboo species namely Yushania alpina and Oxytenantheria abyssinica, covering about one million ha with a wide distribution. The objective of this paper is to highlight the potential of bamboo resources, challenges including biodeterioration damage, opportunities and future research directions towards its sustainable management and rational utilization.Area of study: Bamboo resources of EthiopiaMaterial and Methods: Reconnaissance survey was done to some parts of the bamboo growing potential areas in Ethiopia besides the literature review. Main results: The bamboo resource, despite its socio-economic and environmental benefits, currently, in most areas has been under high pressure due to land use changes, bamboo mass- flowering, poor processing with low value addition, and damage by biodeteriorating agents (termites, beetles and fungi. The preservative tests on Ethiopian bamboos revealed low natural durability and highlighted the paramount importance of appropriate protection measures such as Tanalith and vehicles used motor oil to increase durability, service life and rational utilization of bamboo-based products and structures as potential alternative construction and furniture material.Research highlights: Therefore, integrated research and development interventions involving different propagation and managements techniques, harvesting season, processing, value addition including proper seasoning and preservation technologies and marketing are recommended to fill the information and technological gaps on sustainable management and rational utilization of this fast growing and multipurpose bamboo resources in Ethiopia.Key words: Bamboo; challenges; management; socio-economic and environmental significance; utilization.
Stevens, Rebecca S [Los Alamos National Laboratory; Mc Clelland - Kerr, John [NNSA-NA-242; Senzaki, Masao [JAEA; Hori, Masato [JAEA
The United States Department of Energy/National Nuclear Security Administration (DOE/NNSA) has been cooperating with Japan on nuclear safeguards for over thirty years. DOE/NNSA has collaborated with the Japan Atomic Energy Agency (JAEA) and its predecessors in addressing the need for innovative solutions to nuclear transparency and verification issues in one of the world's most advanced nuclear fuel cycle states. This collaboration includes over ninety activities that have involved nearly every facility in the JAEA complex and many national laboratories in the U.S. complex. The partnership has yielded new technologies and approaches that have benefited international safeguards not only in Japan, but around the world. The International Atomic Energy Agency uses a number of safeguards solutions developed under this collaboration to improve its inspection efforts in Japan and elsewhere. Japanese facilities serve as test beds for emerging safeguards technologies and are setting the trend for new nuclear energy and fuel cycle development worldwide. The collaboration continues to be an essential component of U.S. safeguards outreach and is integral to the DOE/NNSA's Next Generation Safeguards Initiative. In addition to fostering international safeguards development, the cooperation is an opportunity for U.S. scientists to work in facilities that have no analog in the United States, thus providing crucial real-life experience for and aiding development of the next generation of U.S. safeguards specialists. It is also an important element of promoting regional transparency thereby building confidence in the peaceful nature of nuclear programs in the region. The successes engendered by this partnership provide a strong basis for addressing future safeguards challenges, in Japan and elsewhere. This paper summarizes these challenges and the associated cooperative efforts that are either underway or anticipated.
Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells and oncology is a branch of medicine that deals with tumors. The last decade has seen significant advances in the development of biomarkers in oncology that play a critical role in understanding molecular and cellular mechanisms which drive tumor initiation, maintenance and progression. Clinical molecular diagnostics and biomarker discoveries in oncology are advancing rapidly as we begin to understand the complex mechanisms that transform a normal cell into an abnormal one. These discoveries have fueled the development of novel drug targets and new treatment strategies. The standard of care for patients with advanced-stage cancers has shifted away from an empirical treatment strategy based on the clinical-pathological profile to one where a biomarker driven treatment algorithm based on the molecular profile of the tumor is used. Recent advances in multiplex genotyping technologies and high-throughput genomic profiling by next-generation sequencing make possible the rapid and comprehensive analysis of the cancer genome of individual patients even from very little tumor biopsy material. Predictive (diagnostic) biomarkers are helpful in matching targeted therapies with patients and in preventing toxicity of standard (systemic) therapies. Prognostic biomarkers identify somatic germ line mutations, changes in DNA methylation, elevated levels of microRNA (miRNA) and circulating tumor cells (CTC) in blood. Predictive biomarkers using molecular diagnostics are currently in use in clinical practice of personalized oncotherapy for the treatment of five diseases: chronic myeloid leukemia, colon, breast, lung cancer and melanoma and these biomarkers are being used successfully to evaluate benefits that can be achieved through targeted therapy. Examples of these molecularly targeted biomarker therapies are: tyrosine kinase inhibitors in chronic myeloid leukemia and
In addition to the prolonged economic recession and global financial crisis, the Great East Japan Earthquake of March 2011 has caused great fear and devastation in Japan. In the midst of these, Japanese people have felt to lose the traditional values and common sense they used to share, and it has become necessary to build a new consciousness. Engaged in psychiatry and psychiatric care under these circumstances, we have to analyze the challenges we face and to brainstorm on appropriate prescriptions that can be applied to solve the problems. Five points in particular were brought up:  The persistently high number of suicides.  The increase in depression and overflowing numbers of patients visiting clinics and outpatient departments at hospitals.  The absolute shortage of child psychiatrists.  Little progress with the transition from hospitalization-centered to community-centered medical care.  The disappearance of beds for psychiatry patients from general hospitals. The situations surrounding these five issues were briefly analyzed and problems were pointed out. The following are five problems that psychiatry is facing: 1) A lack of large clinical trials compared to the rest of the world. 2) The drug lag and handling of global trials. 3) The lack of staff involved in education and research (in the field of psychiatry). 4) Following the DSM diagnostic criteria dogmatically, without differentiating therapeutics. 5) Other medical departments, the industry, patients, and their families are demanding objective diagnostic techniques. After analyzing the problems, and discussing to some extent what kind of prescription may be considered to solve the problems, I gave my opinion. (1) The first problem is the deep-rooted prejudice and discrimination against psychiatric disorders that continue to be present among Japanese people. The second problem is the government's policy of low remuneration (fees) for psychiatric services. The third problem, symbolic of the
Via a consultation process, the PEROSH members identified what occupational safety and health topics the European institutes specialised in, and what they see as the major trends and future challenges in the world of work and their impact on OSH. A second part of the consultation analysed future
Fiber laser is a fast growing yet quite young type of laser with huge potential in healthcare due to versatility and reliability. The talk discusses present and future for fiber lasers for medical applications and address future challenges and competitions with other sources.
Via a consultation process, the PEROSH members identified what occupational safety and health topics the European institutes specialised in, and what they see as the major trends and future challenges in the world of work and their impact on OSH. A second part of the consultation analysed future res
This presentation will provide an overview of current human spaceflight operations. It will also describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. Additionally, there are many implications regarding advanced automation and robotics, and this presentation will outline future human-automation-robotic integration challenges.
Quesnel, Etienne; Roux, Frédéric; Emieux, Fabrice; Faucherand, Pascal; Kymakis, Emmanuel; Volonakis, George; Giustino, Feliciano; Martín-García, Beatriz; Moreels, Iwan; Alkan Gürsel, Selmiye; Bayrakçeken Yurtcan, Ayşe; Di Noto, Vito; Talyzin, Alexandr; Baburin, Igor; Tranca, Diana; Seifert, Gotthard; Crema, Luigi; Speranza, Giorgio; Tozzini, Valentina; Bondavalli, Paolo; Pognon, Grégory; Botas, Cristina; Carriazo, Daniel; Singh, Gurpreet; Rojo, Teófilo; Kim, Gunwoo; Yu, Wanjing; Grey, Clare P.; Pellegrini, Vittorio
Here we report on technology developments implemented into the Graphene Flagship European project for the integration of graphene and graphene-related materials (GRMs) into energy application devices. Many of the technologies investigated so far aim at producing composite materials associating graphene or GRMs with either metal or semiconducting nanocrystals or other carbon nanostructures (e.g., CNT, graphite). These composites can be used favourably as hydrogen storage materials or solar cell absorbers. They can also provide better performing electrodes for fuel cells, batteries, or supercapacitors. For photovoltaic (PV) electrodes, where thin layers and interface engineering are required, surface technologies are preferred. We are using conventional vacuum processes to integrate graphene as well as radically new approaches based on laser irradiation strategies. For each application, the potential of implemented technologies is then presented on the basis of selected experimental and modelling results. It is shown in particular how some of these technologies can maximize the benefit taken from GRM integration. The technical challenges still to be addressed are highlighted and perspectives derived from the running works emphasized.
Through a robust partnership with the aviation industry, over the past 50 years NASA programs have helped foster advances in propulsion technology that enabled substantial reductions in fuel consumption for commercial transports. Emerging global trends and continuing environmental concerns are creating challenges that will very likely transform the face of aviation over the next 20-40 years. In recognition of this development, NASA Aeronautics has established a set of Research Thrusts that will help define the future direction of the agency's research technology efforts. Two of these thrusts, Ultra-Efficient Commercial Vehicles and Transition to Low-Carbon Propulsion, serve as cornerstones for the Advanced Air Transport Technology (AATT) project. The AATT project is exploring and developing high-payoff technologies and concepts that are key to continued improvement in energy efficiency and environmental compatibility for future generations of fixed-wing, subsonic transports. The AATT project is primarily focused on the N+3 timeframe, or 3 generations from current technology levels. As should be expected, many of the propulsion system architectures technologies envisioned for N+3 vary significantly from todays engines. The use of batteries in a hybrid-electric configuration or deploying multiple fans distributed across the airframe to enable higher bypass ratios are just two examples of potential advances that could enable substantial energy reductions over current propulsion systems.
Shamoo, Adil E
In the past three decades, there has been an explosion in research to understand the mechanisms of brain function. Recent advances in psychophysiology and neuroscience, while still limited, have sparked great interest in developing technologies that could peer into the brain and be used to identify or indicate certain behaviors. The polygraph (lie detector) represents an old technology used for discerning clues to the human brain; functional magnetic resonance imaging (fMRI) represents one of the newest efforts. The use of these technologies in intelligence and counterintelligence in the field without validation represents a major concern about its usefulness. Both research on this new technology and subsequent use on public raise ethical challenges. This article will address the overall ethical issues associated with these new technologies. The report identifies the ethical and cultural challenges in conducting research on these new tools, explores the possibility of using current U.S. regulatory requirements regarding drugs and devices as a model for regulating these new technologies, and suggests approaches for the future.
Pan, Yi; Kim, Cheon-Shik; Yang, Yun
The new multimedia standards (for example, MPEG-21) facilitate the seamless integration of multiple modalities into interoperable multimedia frameworks, transforming the way people work and interact with multimedia data. These key technologies and multimedia solutions interact and collaborate with each other in increasingly effective ways, contributing to the multimedia revolution and having a significant impact across a wide spectrum of consumer, business, healthcare, education, and governmental domains. This book aims to provide a complete coverage of the areas outlined and to bring together the researchers from academic and industry as well as practitioners to share ideas, challenges, and solutions relating to the multifaceted aspects of this field.
Floreano, Dario; Wood, Robert J
We are witnessing the advent of a new era of robots - drones - that can autonomously fly in natural and man-made environments. These robots, often associated with defence applications, could have a major impact on civilian tasks, including transportation, communication, agriculture, disaster mitigation and environment preservation. Autonomous flight in confined spaces presents great scientific and technical challenges owing to the energetic cost of staying airborne and to the perceptual intelligence required to negotiate complex environments. We identify scientific and technological advances that are expected to translate, within appropriate regulatory frameworks, into pervasive use of autonomous drones for civilian applications.
Floreano, Dario; Wood, Robert J.
We are witnessing the advent of a new era of robots -- drones -- that can autonomously fly in natural and man-made environments. These robots, often associated with defence applications, could have a major impact on civilian tasks, including transportation, communication, agriculture, disaster mitigation and environment preservation. Autonomous flight in confined spaces presents great scientific and technical challenges owing to the energetic cost of staying airborne and to the perceptual intelligence required to negotiate complex environments. We identify scientific and technological advances that are expected to translate, within appropriate regulatory frameworks, into pervasive use of autonomous drones for civilian applications.
Dittmann, Lars; Christiansen, Henrik Lehrmann; Checko, Aleksandra
In future mobile networks aggregation at different levels is necessary but at the same time imposes challenges that mandate looking into new architectures. This paper presents the design consideration approach for a C-RAN based mobile aggregation network used in the EU HARP project. With this arc......In future mobile networks aggregation at different levels is necessary but at the same time imposes challenges that mandate looking into new architectures. This paper presents the design consideration approach for a C-RAN based mobile aggregation network used in the EU HARP project....... With this architecture fronthaul aggregation is performed which might be an option for future generation of mobile networks....
António M. Lopes
Full Text Available The Moore’s law (ML is one of many empirical expressions that is used to characterize natural and artificial phenomena. The ML addresses technological progress and is expected to predict future trends. Yet, the “art” of predicting is often confused with the accurate fitting of trendlines to past events. Presently, data-series of multiple sources are available for scientific and computational processing. The data can be described by means of mathematical expressions that, in some cases, follow simple expressions and empirical laws. However, the extrapolation toward the future is considered with skepticism by the scientific community, particularly in the case of phenomena involving complex behavior. This paper addresses these issues in the light of entropy and pseudo-state space. The statistical and dynamical techniques lead to a more assertive perspective on the adoption of a given candidate law.
Full Text Available The paper presents the environmental impact created through the introduction of introducing new technologies in transportation domain. New electric vehicles are considered zero-emission vehicles (ZEV. However, electricity produced in power plants is still predominantly based on fossil fuel usage (required for recharge electric vehicle batteries and thus directly affects the quantity of pollutant emissions and greenhouse gases (CO2, NOx and SOx. Given the structure of EU-wide energy sources used for electricity generation, the potential pollutant emissions stemming from these energy sources, related to energy consumption of an electric vehicle, was determined under the projected environmental impact of specific market penetration of electric vehicles. In addition to the overall impact at the EU level, were identified the countries for which the use of electric vehicles is (or not feasible in terms of reaching the lower values of future emissions compared to the present and future European standards.
Full Text Available This literature review addresses the main effects and challenges in using information and communication technologies (ICT in medical education and practice. The first challenge is to better prepare future physicians for the changing behaviours of patients, who are increasingly Internet-savvy and who sometimes appear to know more about their diseases than their physicians. The second challenge, which is closely linked to the first, is to raise awareness among physicians in training of the many benefits of using ICT to improve not only the quality of interventions and health care delivery but, from a broader perspective, the organization of the health care system itself. The third challenge is to motivate medical students and practitioners to use ICT to find information, learn and develop. It is proposed that information literacy should be a mandatory skill for all medical students. The e-learning mode of training is also addressed. Although underemployed in most medical faculties, it represents the future of initial and continuous medical training. Virtual resources and communities, simulations and 3D animations are also discussed. The fourth and final challenge is to change medical teaching practices.