WorldWideScience

Sample records for fusion machinery yields

  1. Conflicting views on the membrane fusion machinery and the fusion pore

    DEFF Research Database (Denmark)

    Sørensen, Jakob B

    2009-01-01

    of the assembly of the fusogenic SNARE-complex. Here, I review conflicting views on the function of the core fusion machinery consisting of the SNAREs, Munc18, complexin, and synaptotagmin. Munc18 controls docking of vesicles to the plasma membrane and initial SNARE-complex assembly, whereas complexin...

  2. Conservation of proteo-lipid nuclear membrane fusion machinery during early embryogenesis.

    Science.gov (United States)

    Byrne, Richard D; Veeriah, Selvaraju; Applebee, Christopher J; Larijani, Banafshé

    2014-01-01

    The fusogenic lipid diacylglycerol is essential for remodeling gamete and zygote nuclear envelopes (NE) during early embryogenesis. It is unclear whether upstream signaling molecules are likewise conserved. Here we demonstrate PLCγ and its activator SFK1, which co-operate during male pronuclear envelope formation, also promote the subsequent male and female pronuclear fusion. PLCγ and SFK1 interact directly at the fusion site leading to PLCγ activation. This is accompanied by a spatially restricted reduction of PtdIns(4,5)P2. Consequently, pronuclear fusion is blocked by PLCγ or SFK1 inhibition. These findings identify new regulators of events in the early embryo and suggest a conserved "toolkit" of fusion machinery drives successive NE fusion events during embryogenesis.

  3. Machinery running state identification based on discriminant semi-supervised local tangent space alignment for feature fusion and extraction

    International Nuclear Information System (INIS)

    Su, Zuqiang; Xiao, Hong; Zhang, Yi; Tang, Baoping; Jiang, Yonghua

    2017-01-01

    Extraction of sensitive features is a challenging but key task in data-driven machinery running state identification. Aimed at solving this problem, a method for machinery running state identification that applies discriminant semi-supervised local tangent space alignment (DSS-LTSA) for feature fusion and extraction is proposed. Firstly, in order to extract more distinct features, the vibration signals are decomposed by wavelet packet decomposition WPD, and a mixed-domain feature set consisted of statistical features, autoregressive (AR) model coefficients, instantaneous amplitude Shannon entropy and WPD energy spectrum is extracted to comprehensively characterize the properties of machinery running state(s). Then, the mixed-dimension feature set is inputted into DSS-LTSA for feature fusion and extraction to eliminate redundant information and interference noise. The proposed DSS-LTSA can extract intrinsic structure information of both labeled and unlabeled state samples, and as a result the over-fitting problem of supervised manifold learning and blindness problem of unsupervised manifold learning are overcome. Simultaneously, class discrimination information is integrated within the dimension reduction process in a semi-supervised manner to improve sensitivity of the extracted fusion features. Lastly, the extracted fusion features are inputted into a pattern recognition algorithm to achieve the running state identification. The effectiveness of the proposed method is verified by a running state identification case in a gearbox, and the results confirm the improved accuracy of the running state identification. (paper)

  4. Enhancing the muon-catalyzed fusion yield

    International Nuclear Information System (INIS)

    Jones, S.E.

    1987-01-01

    Much has been learned about muon-catalyzed fusion since the last conference on emerging nuclear energy systems. Here the authors consider what they have learned about enhancing the muon-catalyzed fusion energy yield

  5. Effect of machinery wheel load on grass yield

    DEFF Research Database (Denmark)

    Green, Ole; Jørgensen, Rasmus Nyholm; Kristensen, Kristian

    2010-01-01

    Effect of machinery wheel load on grass   Ole Green1, Rasmus N. Jørgensen2, Kristian Kristensen3, René Gislum3, Dionysis Bochtis1, & Claus G. Sørensen1   1University of Aarhus, Dept. of Agricultural Engineering 2University of Southern Denmark, Inst. of Chemical Eng., Biotechnology and Environmental...... 3University of Aarhus, Dept. of Genetics and Biotechnology   Corresponding author: Ole Green Address & e-mail: Research Centre Foulum, Blichers Allé 20, 8830 Tjele. Ole.Green@agrsci.dk     Abstract   Different traffic intensities have been shown to have a negative influence on the yield of grass...... and clover. A full scale grass-clover field trial was established to estimate the effect on clover-grass yields as a function of different wheel loads and tire pressures. The trial comprised 16 different traffic intensities with 35 replicates and 1 traffic free treatment with 245 replicates, totalling 17...

  6. An integrated multi-sensor fusion-based deep feature learning approach for rotating machinery diagnosis

    Science.gov (United States)

    Liu, Jie; Hu, Youmin; Wang, Yan; Wu, Bo; Fan, Jikai; Hu, Zhongxu

    2018-05-01

    The diagnosis of complicated fault severity problems in rotating machinery systems is an important issue that affects the productivity and quality of manufacturing processes and industrial applications. However, it usually suffers from several deficiencies. (1) A considerable degree of prior knowledge and expertise is required to not only extract and select specific features from raw sensor signals, and but also choose a suitable fusion for sensor information. (2) Traditional artificial neural networks with shallow architectures are usually adopted and they have a limited ability to learn the complex and variable operating conditions. In multi-sensor-based diagnosis applications in particular, massive high-dimensional and high-volume raw sensor signals need to be processed. In this paper, an integrated multi-sensor fusion-based deep feature learning (IMSFDFL) approach is developed to identify the fault severity in rotating machinery processes. First, traditional statistics and energy spectrum features are extracted from multiple sensors with multiple channels and combined. Then, a fused feature vector is constructed from all of the acquisition channels. Further, deep feature learning with stacked auto-encoders is used to obtain the deep features. Finally, the traditional softmax model is applied to identify the fault severity. The effectiveness of the proposed IMSFDFL approach is primarily verified by a one-stage gearbox experimental platform that uses several accelerometers under different operating conditions. This approach can identify fault severity more effectively than the traditional approaches.

  7. Fusion Yield Enhancement in Magnetized Laser-Driven Implosions

    International Nuclear Information System (INIS)

    Chang, P. Y.; Fiksel, G.; Hohenberger, M.; Knauer, J. P.; Marshall, F. J.; Betti, R.; Meyerhofer, D. D.; Seguin, F. H.; Petrasso, R. D.

    2011-01-01

    Enhancement of the ion temperature and fusion yield has been observed in magnetized laser-driven inertial confinement fusion implosions on the OMEGA Laser Facility. A spherical CH target with a 10 atm D 2 gas fill was imploded in a polar-drive configuration. A magnetic field of 80 kG was embedded in the target and was subsequently trapped and compressed by the imploding conductive plasma. As a result of the hot-spot magnetization, the electron radial heat losses were suppressed and the observed ion temperature and neutron yield were enhanced by 15% and 30%, respectively.

  8. Fault Diagnosis of Rotating Machinery Based on Multisensor Information Fusion Using SVM and Time-Domain Features

    Directory of Open Access Journals (Sweden)

    Ling-li Jiang

    2014-01-01

    Full Text Available Multisensor information fusion, when applied to fault diagnosis, the time-space scope, and the quantity of information are expanded compared to what could be acquired by a single sensor, so the diagnostic object can be described more comprehensively. This paper presents a methodology of fault diagnosis in rotating machinery using multisensor information fusion that all the features are calculated using vibration data in time domain to constitute fusional vector and the support vector machine (SVM is used for classification. The effectiveness of the presented methodology is tested by three case studies: diagnostic of faulty gear, rolling bearing, and identification of rotor crack. For each case study, the sensibilities of the features are analyzed. The results indicate that the peak factor is the most sensitive feature in the twelve time-domain features for identifying gear defect, and the mean, amplitude square, root mean square, root amplitude, and standard deviation are all sensitive for identifying gear, rolling bearing, and rotor crack defect comparatively.

  9. Possible application of electromagnetic guns to impact fusion

    Science.gov (United States)

    Kostoff, R. N.; Peaslee, A. T., Jr.; Ribe, F. L.

    1982-01-01

    The possible application of electromagnetic guns to impact fusion for the generation of electric power is discussed, and advantages of impact fusion over the more conventional inertial confinement fusion concepts are examined. It is shown that impact fusion can achieve the necessary high yields, of the order of a few gigajoules, which are difficult to achieve with lasers except at unrealistically high target gains. The rail gun accelerator is well adapted to the delivery of some 10-100 megajoules of energy to the fusion target, and the electrical technology involved is relatively simple: inductive storage or rotating machinery and capacitors. It is concluded that the rail gun has the potential of developing into an impact fusion macroparticle accelerator.

  10. The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery

    Directory of Open Access Journals (Sweden)

    Anna Bodzęta

    2017-08-01

    Full Text Available Vacuolar H+-ATPase (v-ATPase is a multi-subunit complex comprising two domains: the cytosolic V1 domain catalyzing ATP hydrolysis and the membranous V0 sector translocating protons across membranes. In addition to proton pumping, a direct function of the V0 proteolipid ring in membrane fusion has been proposed for yeast vacuolar fusion and synaptic vesicle exocytosis in Drosophila. Here, we show in cultured hippocampal neurons that in recycling synaptic vesicles, v-ATPases are only transiently assembled in a pH-dependent fashion during the tightly coupled cycle of exo-endocytosis. Upon locking v-ATPase in an assembled state by saliphenylhalamide, we observed use- and time-dependent release depression for stimuli exceeding release of primed vesicles but no abrogation of exocytosis. Thus, the membranous V0 sector is not part of the exocytotic fusion machinery. Instead, v-ATPase modulates release upstream of docking to favor fusion of fully filled synaptic vesicles.

  11. Effects of pellet yield on electricity cost in laser fusion generating stations

    International Nuclear Information System (INIS)

    Bohachevsky, I.O.; Booth, L.A.; Hafer, J.F.; Pendergrass, J.H.

    1978-01-01

    The dependence of capital and net electricity production costs on fuel pellet yield is investigated for laser fusion reactors based on the magnetically protected and the wetted wall reactor cavity concepts. It is determined that above a certain pellet yield, which depends on the cavity concept, diseconomies of scale occur and the costs per unit output increase with increasing fuel pellet yield. This behavior, determined with the trade-off and analysis computer code TROFAN, is explained through analytical examination of the scaling rules for the laser fusion reactor components

  12. Bacterial mitotic machineries

    DEFF Research Database (Denmark)

    Gerdes, Kenn; Møller-Jensen, Jakob; Ebersbach, Gitte

    2004-01-01

    Here, we review recent progress that yields fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells. In particular, we describe how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division. Thus, the P......M protein of plasmid R1 forms F actin-like filaments that separate and move plasmid DNA from mid-cell to the cell poles. Evidence from three different laboratories indicate that the morphogenetic MreB protein may be involved in segregation of the bacterial chromosome.......Here, we review recent progress that yields fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells. In particular, we describe how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division. Thus, the Par...

  13. High-Yield Lithium-Injection Fusion-Energy (HYLIFE) reactor

    International Nuclear Information System (INIS)

    Blink, J.A.; Hogam, W.J.; Hovingh, J.; Meier, E.R.; Pitts, J.H.

    1985-01-01

    The High-Yield Lithium-Injection Fusion Energy (HYLIFE) concept to convent inertial confinement fusion energy into electric power has undergone intensive research and refinement at LLNL since 1978. This paper reports on the final HYLIFE design, focusing on five major areas: the HYLIFE reaction chamber (which includes neutronics, liquid-metal jet-array hydrocynamics, and structural design), supporting systems, primary steam system and balance of plant, safety and environmental protection, and costs. An annotated bibliography of reports applicable to HYLIFE is also provided. We conclude that HYLIFE is a particularly viable concept for the safe, clean production of electrical energy. The liquid-metal jet array, HYLIFE's key design feature, protects the surrounding structural components from x-rays, fusion fuel-pellet debris, neutron damage and activation, and high temperatures and stresses, allowing the structure to last for the plant's entire 30-year lifetime without being replaced. 127 refs., 18 figs

  14. Fusion yield rate recovery by escaping hot-spot fast ions in the neighboring fuel layer

    Science.gov (United States)

    Tang, Xian-Zhu; McDevitt, C. J.; Guo, Zehua; Berk, H. L.

    2014-02-01

    Free-streaming loss by fast ions can deplete the tail population in the hot spot of an inertial confinement fusion (ICF) target. Escaping fast ions in the neighboring fuel layer of a cryogenic target can produce a surplus of fast ions locally. In contrast to the Knudsen layer effect that reduces hot-spot fusion reactivity due to tail ion depletion, the inverse Knudsen layer effect increases fusion reactivity in the neighboring fuel layer. In the case of a burning ICF target in the presence of significant hydrodynamic mix which aggravates the Knudsen layer effect, the yield recovery largely compensates for the yield reduction. For mix-dominated sub-ignition targets, the yield reduction is the dominant process.

  15. Fusion neutron yield and flux calculation on HT-7 superconducting tokamak

    International Nuclear Information System (INIS)

    Fu Yanzhang; Zhu Yubao; Chen Juequan

    2006-01-01

    Neutron yield and flux have been numerically estimated on HT-7 tokamak. The total fusion neutron yield and neutron flux distribution on different positions and azimuth angles of the device are presented. Analyses on the errors induced by ion temperature and density distribution factors are given in detail. The results of the calculations provide a useful database for neutron diagnostics and neutron radiation protection. (authors)

  16. Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport.

    Science.gov (United States)

    Arlt, Henning; Auffarth, Kathrin; Kurre, Rainer; Lisse, Dominik; Piehler, Jacob; Ungermann, Christian

    2015-04-01

    Organelles of the endolysosomal system undergo multiple fission and fusion events to combine sorting of selected proteins to the vacuole with endosomal recycling. This sorting requires a consecutive remodeling of the organelle surface in the course of endosomal maturation. Here we dissect the remodeling and fusion machinery on endosomes during the process of endocytosis. We traced selected GFP-tagged endosomal proteins relative to exogenously added fluorescently labeled α-factor on its way from the plasma membrane to the vacuole. Our data reveal that the machinery of endosomal fusion and ESCRT proteins has similar temporal localization on endosomes, whereas they precede the retromer cargo recognition complex. Neither deletion of retromer nor the fusion machinery with the vacuole affects this maturation process, although the kinetics seems to be delayed due to ESCRT deletion. Of importance, in strains lacking the active Rab7-like Ypt7 or the vacuolar SNARE fusion machinery, α-factor still proceeds to late endosomes with the same kinetics. This indicates that endosomal maturation is mainly controlled by the early endosomal fusion and remodeling machinery but not the downstream Rab Ypt7 or the SNARE machinery. Our data thus provide important further understanding of endosomal biogenesis in the context of cargo sorting. © 2015 Arlt et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  17. Potential design modifications for the High Yield Lithium Injection Fusion Energy (HYLIFE) reaction chamber

    International Nuclear Information System (INIS)

    Pitts, J.H.; Hovingh, J.; Meier, W.R.; Monsler, M.J.; Powell, E.G.; Walker, P.E.

    1979-01-01

    Generation of electric power from inertial confinement fusion requires a reaction chamber. One promising type, the High Yield Lithium Injection Fusion Energy (HYLIFE) chamber, includes a falling array of liquid lithium jets. These jets act as: (1) a renewable first wall and blanket to shield metal components from x-ray and neutron exposure, (2) a tritium breeder to replace tritium burned during the fusion process, and (3) an absorber and transfer medium for fusion energy. Over 90% of the energy produced in the reaction chamber is absorbed in the lithium jet fall. Design aspects are included

  18. Target design for high fusion yield with the double Z-pinch-driven hohlraum

    International Nuclear Information System (INIS)

    Vesey, R. A.; Herrmann, M. C.; Lemke, R. W.; Desjarlais, M. P.; Cuneo, M. E.; Stygar, W. A.; Bennett, G. R.; Campbell, R. B.; Christenson, P. J.; Mehlhorn, T. A.; Porter, J. L.; Slutz, S. A.

    2007-01-01

    A key demonstration on the path to inertial fusion energy is the achievement of high fusion yield (hundreds of MJ) and high target gain. Toward this goal, an indirect-drive high-yield inertial confinement fusion (ICF) target involving two Z-pinch x-ray sources heating a central secondary hohlraum is described by Hammer et al. [Phys. Plasmas 6, 2129 (1999)]. In subsequent research at Sandia National Laboratories, theoretical/computational models have been developed and an extensive series of validation experiments have been performed to study hohlraum energetics, capsule coupling, and capsule implosion symmetry for this system. These models have been used to design a high-yield Z-pinch-driven ICF target that incorporates the latest experience in capsule design, hohlraum symmetry control, and x-ray production by Z pinches. An x-ray energy output of 9 MJ per pinch, suitably pulse-shaped, is sufficient for this concept to drive 0.3-0.5 GJ capsules. For the first time, integrated two-dimensional (2D) hohlraum/capsule radiation-hydrodynamics simulations have demonstrated adequate hohlraum coupling, time-dependent radiation symmetry control, and the successful implosion, ignition, and burn of a high-yield capsule in the double Z-pinch hohlraum. An important new feature of this target design is mode-selective symmetry control: the use of burn-through shields offset from the capsule that selectively tune certain low-order asymmetry modes (P 2 ,P 4 ) without significantly perturbing higher-order modes and without a significant energy penalty. This paper will describe the capsule and hohlraum design that have produced 0.4-0.5 GJ yields in 2D simulations, provide a preliminary estimate of the Z-pinch load and accelerator requirements necessary to drive the system, and suggest future directions for target design work

  19. Application of DNA Machineries for the Barcode Patterned Detection of Genes or Proteins.

    Science.gov (United States)

    Zhou, Zhixin; Luo, Guofeng; Wulf, Verena; Willner, Itamar

    2018-06-05

    The study introduces an analytical platform for the detection of genes or aptamer-ligand complexes by nucleic acid barcode patterns generated by DNA machineries. The DNA machineries consist of nucleic acid scaffolds that include specific recognition sites for the different genes or aptamer-ligand analytes. The binding of the analytes to the scaffolds initiate, in the presence of the nucleotide mixture, a cyclic polymerization/nicking machinery that yields displaced strands of variable lengths. The electrophoretic separation of the resulting strands provides barcode patterns for the specific detection of the different analytes. Mixtures of DNA machineries that yield, upon sensing of different genes (or aptamer ligands), one-, two-, or three-band barcode patterns are described. The combination of nucleic acid scaffolds acting, in the presence of polymerase/nicking enzyme and nucleotide mixture, as DNA machineries, that generate multiband barcode patterns provide an analytical platform for the detection of an individual gene out of many possible genes. The diversity of genes (or other analytes) that can be analyzed by the DNA machineries and the barcode patterned imaging is given by the Pascal's triangle. As a proof-of-concept, the detection of one of six genes, that is, TP53, Werner syndrome, Tay-Sachs normal gene, BRCA1, Tay-Sachs mutant gene, and cystic fibrosis disorder gene by six two-band barcode patterns is demonstrated. The advantages and limitations of the detection of analytes by polymerase/nicking DNA machineries that yield barcode patterns as imaging readout signals are discussed.

  20. Herpesvirus glycoproteins undergo multiple antigenic changes before membrane fusion.

    Directory of Open Access Journals (Sweden)

    Daniel L Glauser

    Full Text Available Herpesvirus entry is a complicated process involving multiple virion glycoproteins and culminating in membrane fusion. Glycoprotein conformation changes are likely to play key roles. Studies of recombinant glycoproteins have revealed some structural features of the virion fusion machinery. However, how the virion glycoproteins change during infection remains unclear. Here using conformation-specific monoclonal antibodies we show in situ that each component of the Murid Herpesvirus-4 (MuHV-4 entry machinery--gB, gH/gL and gp150--changes in antigenicity before tegument protein release begins. Further changes then occurred upon actual membrane fusion. Thus virions revealed their final fusogenic form only in late endosomes. The substantial antigenic differences between this form and that of extracellular virions suggested that antibodies have only a limited opportunity to block virion membrane fusion.

  1. Effect of laser spot size on fusion neutron yield in laser–deuterium cluster interactions

    International Nuclear Information System (INIS)

    Chen Guanglong; Lu Haiyang; Wang Cheng; Liu Jiansheng; Li Ruxin; Ni Guoquan; Xu Zhizhan

    2008-01-01

    The effect of the laser spot size on the neutron yield of table-top nuclear fusion from explosions of a femtosecond intense laser pulse heated deuterium clusters is investigated by using a simplified model, in which the cluster size distribution and the energy attenuation of the laser as it propagates through the cluster jet are taken into account. It has been found that there exists a proper laser spot size for the maximum fusion neutron yield for a given laser pulse and a specific deuterium gas cluster jet. The proper spot size, which is dependent on the laser parameters and the cluster jet parameters, has been calculated and compared with the available experimental data. A reasonable agreement between the calculated results and the published experimental results is found

  2. Demonstration of radiation pulse shaping with nested-tungsten-wire-array pinches for high-yield inertial confinement fusion.

    Science.gov (United States)

    Cuneo, M E; Vesey, R A; Sinars, D B; Chittenden, J P; Waisman, E M; Lemke, R W; Lebedev, S V; Bliss, D E; Stygar, W A; Porter, J L; Schroen, D G; Mazarakis, M G; Chandler, G A; Mehlhorn, T A

    2005-10-28

    Nested wire-array pinches are shown to generate soft x-ray radiation pulse shapes required for three-shock isentropic compression and hot-spot ignition of high-yield inertial confinement fusion capsules. We demonstrate a reproducible and tunable foot pulse (first shock) produced by interaction of the outer and inner arrays. A first-step pulse (second shock) is produced by inner array collision with a central CH2 foam target. Stagnation of the inner array at the axis produces the third shock. Capsules optimized for several of these shapes produce 290-900 MJ fusion yields in 1D simulations.

  3. New Fault Recognition Method for Rotary Machinery Based on Information Entropy and a Probabilistic Neural Network.

    Science.gov (United States)

    Jiang, Quansheng; Shen, Yehu; Li, Hua; Xu, Fengyu

    2018-01-24

    Feature recognition and fault diagnosis plays an important role in equipment safety and stable operation of rotating machinery. In order to cope with the complexity problem of the vibration signal of rotating machinery, a feature fusion model based on information entropy and probabilistic neural network is proposed in this paper. The new method first uses information entropy theory to extract three kinds of characteristics entropy in vibration signals, namely, singular spectrum entropy, power spectrum entropy, and approximate entropy. Then the feature fusion model is constructed to classify and diagnose the fault signals. The proposed approach can combine comprehensive information from different aspects and is more sensitive to the fault features. The experimental results on simulated fault signals verified better performances of our proposed approach. In real two-span rotor data, the fault detection accuracy of the new method is more than 10% higher compared with the methods using three kinds of information entropy separately. The new approach is proved to be an effective fault recognition method for rotating machinery.

  4. Microstructural origins of yield-strength changes in AISI 316 during fission or fusion irradiation

    International Nuclear Information System (INIS)

    Garner, F.A.; Hamilton, M.L.; Panayotou, N.F.; Johnson, G.D.

    1981-08-01

    The changes in yield strength of AISI 316 irradiated in breeder reactors have been successfully modeled in terms of concurrent changes in microstructural components. Two new insights involving the strength contributions of voids and Frank loops have been incorporated into the hardening models. Both the radiation-induced microstructure and the yield strength exhibit transients which are then followed by saturation at a level dependent on the irradiation temperature. Extrapolation to anticipated fusion behavior based on microstructural comparisons leads to the conclusion that the primary influence of transmutational differences is only to alter the transient behavior and not the saturation level of yield strength

  5. Atomic force microscopy: Unraveling the fundamental principles governing secretion and membrane fusion in cells

    International Nuclear Information System (INIS)

    Jena, Bhanu P.

    2009-01-01

    The story of cell secretion and membrane fusion is as old as life itself. Without these fundamental cellular processes known to occur in yeast to humans, life would cease to exist. In the last 15 years, primarily using the atomic force microscope, a detailed understanding of the molecular process and of the molecular machinery and mechanism of secretion and membrane fusion in cells has come to light. This has led to a paradigm shift in our understanding of the underlying mechanism of cell secretion. The journey leading to the discovery of a new cellular structure the 'porosome',-the universal secretory machinery in cells, and the contributions of the AFM in our understanding of the general molecular machinery and mechanism of cell secretion and membrane fusion, is briefly discussed in this article.

  6. Premature activation of the paramyxovirus fusion protein before target cell attachment with corruption of the viral fusion machinery.

    Science.gov (United States)

    Farzan, Shohreh F; Palermo, Laura M; Yokoyama, Christine C; Orefice, Gianmarco; Fornabaio, Micaela; Sarkar, Aurijit; Kellogg, Glen E; Greengard, Olga; Porotto, Matteo; Moscona, Anne

    2011-11-04

    Paramyxoviruses, including the childhood pathogen human parainfluenza virus type 3, enter host cells by fusion of the viral and target cell membranes. This fusion results from the concerted action of its two envelope glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion protein (F). The receptor-bound HN triggers F to undergo conformational changes that render it competent to mediate fusion of the viral and cellular membranes. We proposed that, if the fusion process could be activated prematurely before the virion reaches the target host cell, infection could be prevented. We identified a small molecule that inhibits paramyxovirus entry into target cells and prevents infection. We show here that this compound works by an interaction with HN that results in F-activation prior to receptor binding. The fusion process is thereby prematurely activated, preventing fusion of the viral membrane with target cells and precluding viral entry. This first evidence that activation of a paramyxovirus F can be specifically induced before the virus contacts its target cell suggests a new strategy with broad implications for the design of antiviral agents.

  7. On the absolute calibration of a DT fusion neutron yield diagnostic

    Directory of Open Access Journals (Sweden)

    Ruiz C.L.

    2013-11-01

    Full Text Available Recent advances in Inertial Confinement Fusion (ICF experiments at Lawrence Livermore National Laboratory's National Ignition Facility (NIF have underscored the need for accurate total yield measurements of DT neutrons because yield measurements provide a measure of the predicted performance of the experiments. Future gas-puff DT experiments at Sandia National Laboratory's Z facility will also require similar measurements. For ICF DT experiments, the standard technique for measuring the neutron (14.1 MeV yield, counts the activity (counts/minute induced in irradiated copper samples. This activity occurs by the 63Cu(n,2n62Cu reaction where 62Cu decays by positrons (β+ with a half-life of 9.67 minutes. The calibrations discussed here employ the associated-particle method (APM, where the α (4He particles from the T(d,n4He reaction are measured to infer neutron fluxes on a copper sample. The flux induces 62Cu activity, measured in a coincidence counting system. The method leads to a relationship between a DT neutron yield and copper activity known as the F-factor. The goal in future experiments is to apply this calibration to measure the yield at NIF with a combined uncertainty approaching 5%.

  8. Cell secretion machinery: Studies using the AFM

    International Nuclear Information System (INIS)

    Jena, Bhanu P.

    2006-01-01

    A new field in biology, 'nano-cell biology', has emerged from the successful use of force microscopy in understanding the structure and dynamics of cells and biomolecules, at nm resolution and in real time. Atomic force microscopy, in combination with conventional tools and approaches (electron microscopy, electrophysiology, X-ray diffraction, photon correlation spectroscopy, mass spectroscopy, biochemistry, and molecular biology), has revealed for the first time, the universal molecular machinery and mechanism of secretion in cells. Secretion occurs in all living cells and involves the delivery of intracellular products to the cell exterior. Secretory products are packaged and stored in membranous sacs or vesicles within the cell. When the cell needs to secrete these products, the secretory vesicles containing them, dock and fuse at plasma membrane-associated supramolecular structures called Porosome, to release their contents. Specialized cells for neurotransmission, enzyme secretion, or hormone release utilize a highly regulated secretory process. During secretion, swelling of secretory vesicles results in a build-up of intravesicular pressure, allowing expulsion of vesicular contents. The extent of vesicle swelling dictates the amount of vesicular contents expelled. The discovery of the porosome as the universal secretory machinery, its isolation, its structure and dynamics at nm resolution and in real time, its biochemical composition and functional reconstitution into artificial lipid membrane, have been determined. The molecular mechanism of secretory vesicle swelling, and the fusion of opposing bilayers, i.e., the fusion of secretory vesicle membrane at the base of the porosome membrane, has also been resolved

  9. Development of high yield strength non-magnetic steels for the equipments of nuclear fusion research

    International Nuclear Information System (INIS)

    Matsuoka, Hidenori; Mukai, Tetsuya; Ohtani, Hiroo; Tsuruki, Takanori; Okada, Yasutaka

    1979-01-01

    Recently, activity of nuclear fusion research and so forth increase the demand of non-magnetic materials for various equipments and structures. For these usage, very low magnetic permeability as well as high strength are required under high magnetic field. Based on fundamental research, middle C-17% Cr-7% Ni-N non-magnetic steel has been developed. The developed steel shows more stable austenite phase and possesses higher yield strength and endurance limit of more than 10 kg/mm 2 , compared with 18% Cr-8% Ni austenitic steel. Also the developed steel has good ductility and toughness in spite of the high yield strength and shows better machinability than usual high Mn non- magnetic steels. The large forgings of this newly developed steel are manufactured in the works for the equipments of nuclear fusion research and confirmed good mechanical properties, high fatigue strength and low permeability. (author)

  10. Measurements of fusion neutron yields by neutron activation technique: Uncertainty due to the uncertainty on activation cross-sections

    Energy Technology Data Exchange (ETDEWEB)

    Stankunas, Gediminas, E-mail: gediminas.stankunas@lei.lt [Lithuanian Energy Institute, Laboratory of Nuclear Installation Safety, Breslaujos str. 3, LT-44403 Kaunas (Lithuania); EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Batistoni, Paola [ENEA, Via E. Fermi, 45, 00044 Frascati, Rome (Italy); EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Sjöstrand, Henrik; Conroy, Sean [Department of Physics and Astronomy, Uppsala University, PO Box 516, SE-75120 Uppsala (Sweden); EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom)

    2015-07-11

    The neutron activation technique is routinely used in fusion experiments to measure the neutron yields. This paper investigates the uncertainty on these measurements as due to the uncertainties on dosimetry and activation reactions. For this purpose, activation cross-sections were taken from the International Reactor Dosimetry and Fusion File (IRDFF-v1.05) in 640 groups ENDF-6 format for several reactions of interest for both 2.5 and 14 MeV neutrons. Activation coefficients (reaction rates) have been calculated using the neutron flux spectra at JET vacuum vessel, both for DD and DT plasmas, calculated by MCNP in the required 640-energy group format. The related uncertainties for the JET neutron spectra are evaluated as well using the covariance data available in the library. These uncertainties are in general small, but not negligible when high accuracy is required in the determination of the fusion neutron yields.

  11. Remote systems requirements of the high-yield lithium injection fusion energy converter concept

    International Nuclear Information System (INIS)

    Walker, P.E.

    1978-01-01

    Remote systems will be required in the high-yield lithium injection fusion energy converter power plant proposed by Lawrence Livermore Laboratory. During inspection operations, viewing of the chamber interior and certain pumps, valve fittings, and welds must be done remotely. Ideas for remote maintenance of laser-beam blast baffles, optics, and target material traps are described. Radioisotope sources, their distributions, and exposure rates at various points in the reactor vicinity are presented

  12. Development and characterization of a Z-pinch-driven hohlraum high-yield inertial confinement fusion target concept

    International Nuclear Information System (INIS)

    Cuneo, Michael E.; Vesey, Roger A.; Porter, John L. Jr.; Chandler, Gordon A.; Fehl, David L.; Gilliland, Terrance L.; Hanson, David L.; McGurn, John S.; Reynolds, Paul G.; Ruggles, Laurence E.; Seamen, Hans; Spielman, Rick B.; Struve, Ken W.; Stygar, William A.; Simpson, Walter W.; Torres, Jose A.; Wenger, David F.; Hammer, James H.; Rambo, Peter W.; Peterson, Darrell L.

    2001-01-01

    Initial experiments to study the Z-pinch-driven hohlraum high-yield inertial confinement fusion (ICF) concept of Hammer, Tabak, and Porter [Hammer et al., Phys. Plasmas 6, 2129 (1999)] are described. The relationship between measured pinch power, hohlraum temperature, and secondary hohlraum coupling ('hohlraum energetics') is well understood from zero-dimensional semianalytic, and two-dimensional view factor and radiation magnetohydrodynamics models. These experiments have shown the highest x-ray powers coupled to any Z-pinch-driven secondary hohlraum (26±5 TW), indicating the concept could scale to fusion yields of >200 MJ. A novel, single-sided power feed, double-pinch driven secondary that meets the pinch simultaneity requirements for polar radiation symmetry has also been developed. This source will permit investigation of the pinch power balance and hohlraum geometry requirements for ICF relevant secondary radiation symmetry, leading to a capsule implosion capability on the Z accelerator [Spielman et al., Phys. Plasmas 5, 2105 (1998)

  13. Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors.

    Science.gov (United States)

    Ojeda Naharros, Irene; Gesemann, Matthias; Mateos, José M; Barmettler, Gery; Forbes, Austin; Ziegler, Urs; Neuhauss, Stephan C F; Bachmann-Gagescu, Ruxandra

    2017-12-01

    Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous organelles involved in transduction of environmental signals such as light sensation in photoreceptors. Concentration of signal detection proteins such as opsins in the ciliary membrane is achieved by RabGTPase-regulated polarized vesicle trafficking and by a selective barrier at the ciliary base, the transition zone (TZ). Dysfunction of the TZ protein CC2D2A causes Joubert/Meckel syndromes in humans and loss of ciliary protein localization in animal models, including opsins in retinal photoreceptors. The link between the TZ and upstream vesicle trafficking has been little explored to date. Moreover, the role of the small GTPase Rab8 in opsin-carrier vesicle (OCV) trafficking has been recently questioned in a mouse model. Using correlative light and electron microscopy and live imaging in zebrafish photoreceptors, we provide the first live characterization of Rab8-mediated trafficking in photoreceptors in vivo. Our results support a possibly redundant role for both Rab8a/b paralogs in OCV trafficking, based on co-localization of Rab8 and opsins in vesicular structures, and joint movement of Rab8-tagged particles with opsin. We further investigate the role of the TZ protein Cc2d2a in Rab8-mediated trafficking using cc2d2a zebrafish mutants and identify a requirement for Cc2d2a in the latest step of OCV trafficking, namely vesicle fusion. Progressive accumulation of opsin-containing vesicles in the apical portion of photoreceptors lacking Cc2d2a is caused by disorganization of the vesicle fusion machinery at the periciliary membrane with mislocalization and loss of the t-SNAREs SNAP25 and Syntaxin3 and of the exocyst component Exoc4. We further observe secondary defects on upstream Rab8-trafficking with cytoplasmic accumulation of Rab8. Taken together, our results support participation of Rab8 in OCV trafficking and identify a novel role for the TZ protein Cc2d2a in fusion of incoming

  14. Fusion reaction yield in focused discharges with variable energy and plasma fine structure

    International Nuclear Information System (INIS)

    Bortolotti, A.; Brzosko, J.S.; Chiara, P. De; Kilic, H.; Mezzetti, F.; Nardi, V.; Powell, C.; Wang, J.

    1992-01-01

    The same linear correlation between the distribution parameters (ΔT and Max ΔV) of the radial current density J between electrodes and the fusion reaction yield per pulse, Y, in the plasma focus (PF) pinch was quantitatively determined from different PF machines. Contact prints of current-sheath fragments (CSF) ejected from the pinch are obtained from 2.5-MeV-D + ions. CSF's show the same submillimetric fine structure of the pinch. (author) 3 refs., 2 tabs

  15. The Role of Combined ICRF and NBI Heating in JET Hybrid Plasmas in Quest for High D-T Fusion Yield

    Directory of Open Access Journals (Sweden)

    Mantsinen Mervi

    2017-01-01

    Full Text Available Combined ICRF and NBI heating played a key role in achieving the world-record fusion yield in the first deuterium-tritium campaign at the JET tokamak in 1997. The current plans for JET include new experiments with deuterium-tritium (D-T plasmas with more ITER-like conditions given the recently installed ITER-like wall (ILW. In the 2015-2016 campaigns, significant efforts have been devoted to the development of high-performance plasma scenarios compatible with ILW in preparation of the forthcoming D-T campaign. Good progress was made in both the inductive (baseline and the hybrid scenario: a new record JET ILW fusion yield with a significantly extended duration of the high-performance phase was achieved. This paper reports on the progress with the hybrid scenario which is a candidate for ITER longpulse operation (∼1000 s thanks to its improved normalized confinement, reduced plasma current and higher plasma beta with respect to the ITER reference baseline scenario. The combined NBI+ICRF power in the hybrid scenario was increased to 33 MW and the record fusion yield, averaged over 100 ms, to 2.9x1016 neutrons/s from the 2014 ILW fusion record of 2.3x1016 neutrons/s. Impurity control with ICRF waves was one of the key means for extending the duration of the high-performance phase. The main results are reviewed covering both key core and edge plasma issues.

  16. The capacity of sugar beet farms’ machinery and equipment

    Directory of Open Access Journals (Sweden)

    Małgorzata BZOWSKA – BAKALARZ

    2012-12-01

    Full Text Available The survey investigates into equipment of sugar beet farms of the Lublin region, Poland, with machinery – with reference to plantation size and yields. To assess the production potential of the farms, the authors determined the age structure of the machinery owned by the farmers and established the scale of investment in new equipment. The machinery most important for sugar beet production are pre-sowing and post-harvest tillage units, sprayers, seed drills, combine harvesters and self-unloading trailers. In most cases, the surveyed farmers own most of these machines, but they are often obsolete: 37% of them is in operation for more than 15 years. As for the machines dedicated solely to sugar beet growing (harvesters and seeders, their age structure is most unfavourable – 70% of them have been used for over 15 years. A trend towards increasing plantation sizes provides incentives for introducing innovation to cultivation methods. However, the scale of investment in new machinery is small, especially in the case of small and medium-sized farms that dominate in the region. The authors surveyed also the scale of using professional services in the field of tillage processes to determine changes in farming practices.

  17. Remote systems requirements of the High Yield Lithium Injection Fusion Energy (HYLIFE) converter concept

    International Nuclear Information System (INIS)

    Walker, P.E.

    1978-10-01

    Remote systems will be required in the High Yield Lithium Injection Fusion Energy Converter power plant proposed by Lawrence Livermore Laboratory. During inspection operations, viewing of the chamber interior and certain pumps, valve fittings and welds must be done remotely. Ideas for remote maintenance of laser beam blast baffles, optics, and target material traps are described. Radioisotope sources and their distributions, and exposure rates at various points in the reactor vicinity are presented

  18. Congress turns cold on fusion

    International Nuclear Information System (INIS)

    Marshall, E.

    1984-01-01

    A 5% cut in fusion research budgets will force some programs to be dropped in order to keep the large machinery running unless US and European scientists collaborate instead of competing. Legislators became uneasy about the escalating costs of the new devices. The 1984 budget of $470 million for magnetic fusion research is only half the projected cost of the Tokomak Fusion Core Experiment (TFCX) planned to ignite, for the first time, a self-sustaining burn. Planning for the TCFX continued despite the message from Congress. Work at the large institutions at Princeton, MIT, etc. may survive at the expense of other programs, some of which will lose academic programs as well. Scientists point to the loss of new ideas and approaches when projects are cancelled. Enthusiasm is growing for international collaboration

  19. Statistical Relations for Yield Degradation in Inertial Confinement Fusion

    Science.gov (United States)

    Woo, K. M.; Betti, R.; Patel, D.; Gopalaswamy, V.

    2017-10-01

    In inertial confinement fusion (ICF), the yield-over-clean (YOC) is a quantity commonly used to assess the performance of an implosion with respect to the degradation caused by asymmetries. The YOC also determines the Lawson parameter used to identify the onset of ignition and the level of alpha heating in ICF implosions. In this work, we show that the YOC is a unique function of the residual kinetic energy in the compressed shell (with respect to the 1-D case) regardless of the asymmetry spectrum. This result is derived using a simple model of the deceleration phase as well as through an extensive set of 3-D radiation-hydrodynamics simulations using the code DEC3D. The latter has been recently upgraded to include a 3-D spherical moving mesh, the HYPRE solver for 3-D radiation transport and piecewise-parabolic method for robust shock-capturing hydrodynamic simulations. DEC3D is used to build a synthetic single-mode database to study the behavior of yield degradation caused by Rayleigh-Taylor instabilities in the deceleration phase. The relation between YOC and residual kinetic energy is compared with the result in an adiabatic implosion model. The statistical expression of YOC is also applied to the ignition criterion in the presence of multidimensional nonuniformities. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  20. Folding machineries displayed on a cation-exchanger for the concerted refolding of cysteine- or proline-rich proteins

    Directory of Open Access Journals (Sweden)

    Lee Dae-Hee

    2009-03-01

    Full Text Available Abstract Background Escherichia coli has been most widely used for the production of valuable recombinant proteins. However, over-production of heterologous proteins in E. coli frequently leads to their misfolding and aggregation yielding inclusion bodies. Previous attempts to refold the inclusion bodies into bioactive forms usually result in poor recovery and account for the major cost in industrial production of desired proteins from recombinant E. coli. Here, we describe the successful use of the immobilized folding machineries for in vitro refolding with the examples of high yield refolding of a ribonuclease A (RNase A and cyclohexanone monooxygenase (CHMO. Results We have generated refolding-facilitating media immobilized with three folding machineries, mini-chaperone (a monomeric apical domain consisting of residues 191–345 of GroEL and two foldases (DsbA and human peptidyl-prolyl cis-trans isomerase by mimicking oxidative refolding chromatography. For efficient and simple purification and immobilization simultaneously, folding machineries were fused with the positively-charged consecutive 10-arginine tag at their C-terminal. The immobilized folding machineries were fully functional when assayed in a batch mode. When the refolding-facilitating matrices were applied to the refolding of denatured and reduced RNase A and CHMO, both of which contain many cysteine and proline residues, RNase A and CHMO were recovered in 73% and 53% yield of soluble protein with full enzyme activity, respectively. Conclusion The refolding-facilitating media presented here could be a cost-efficient platform and should be applicable to refold a wide range of E. coli inclusion bodies in high yield with biological function.

  1. A methodology for hard/soft information fusion in the condition monitoring of aircraft

    Science.gov (United States)

    Bernardo, Joseph T.

    2013-05-01

    Condition-based maintenance (CBM) refers to the philosophy of performing maintenance when the need arises, based upon indicators of deterioration in the condition of the machinery. Traditionally, CBM involves equipping machinery with electronic sensors that continuously monitor components and collect data for analysis. The addition of the multisensory capability of human cognitive functions (i.e., sensemaking, problem detection, planning, adaptation, coordination, naturalistic decision making) to traditional CBM may create a fuller picture of machinery condition. Cognitive systems engineering techniques provide an opportunity to utilize a dynamic resource—people acting as soft sensors. The literature is extensive on techniques to fuse data from electronic sensors, but little work exists on fusing data from humans with that from electronic sensors (i.e., hard/soft fusion). The purpose of my research is to explore, observe, investigate, analyze, and evaluate the fusion of pilot and maintainer knowledge, experiences, and sensory perceptions with digital maintenance resources. Hard/soft information fusion has the potential to increase problem detection capability, improve flight safety, and increase mission readiness. This proposed project consists the creation of a methodology that is based upon the Living Laboratories framework, a research methodology that is built upon cognitive engineering principles1. This study performs a critical assessment of concept, which will support development of activities to demonstrate hard/soft information fusion in operationally relevant scenarios of aircraft maintenance. It consists of fieldwork, knowledge elicitation to inform a simulation and a prototype.

  2. Improving machinery reliability

    CERN Document Server

    Bloch, Heinz P

    1998-01-01

    This totally revised, updated and expanded edition provides proven techniques and procedures that extend machinery life, reduce maintenance costs, and achieve optimum machinery reliability. This essential text clearly describes the reliability improvement and failure avoidance steps practiced by best-of-class process plants in the U.S. and Europe.

  3. Fusomorphogenesis: cell fusion in organ formation.

    Science.gov (United States)

    Shemer, G; Podbilewicz, B

    2000-05-01

    Cell fusion is a universal process that occurs during fertilization and in the formation of organs such as muscles, placenta, and bones. Very little is known about the molecular and cellular mechanisms of cell fusion during pattern formation. Here we review the dynamic anatomy of all cell fusions during embryonic and postembryonic development in an organism. Nearly all the cell fates and cell lineages are invariant in the nematode C. elegans and one third of the cells that are born fuse to form 44 syncytia in a reproducible and stereotyped way. To explain the function of cell fusion in organ formation we propose the fusomorphogenetic model as a simple cellular mechanism to efficiently redistribute membranes using a combination of cell fusion and polarized membrane recycling during morphogenesis. Thus, regulated intercellular and intracellular membrane fusion processes may drive elongation of the embryo as well as postembryonic organ formation in C. elegans. Finally, we use the fusomorphogenetic hypothesis to explain the role of cell fusion in the formation of organs like muscles, bones, and placenta in mammals and other species and to speculate on how the intracellular machinery that drive fusomorphogenesis may have evolved.

  4. Pumping machinery theory and practice

    CERN Document Server

    Badr, Hassan M

    2014-01-01

    Pumping Machinery Theory and Practice comprehensively covers the theoretical foundation and applications of pumping machinery. Key features: Covers characteristics of centrifugal pumps, axial flow pumps and displacement pumpsConsiders pumping machinery performance and operational-type problemsCovers advanced topics in pumping machinery including multiphase flow principles, and two and three-phase flow pumping systemsCovers different methods of flow rate control and relevance to machine efficiency and energy consumptionCovers different methods of flow rate control and relevance to machine effi

  5. Production method of hydrogen jet plasma process in hydro machinery

    International Nuclear Information System (INIS)

    Amini, F.

    2007-01-01

    The purpose of present paper is to the process of plasma formation in hydro machinery when a hydro turbine operates at various conditions and load rejection. By investigation the power, shock pressure , and impact effects of hydro machinery, it is revealed that energy and hydrogen are generated by the plasma process. The investigation on several turbines of various hydro power plants reveals that cold fusion process in hydro machinery generates hydrogen. The hypothesis concerning the participation of alkaline metals in river water and the atomic nuclei of the runner blade material in the formation of hydrogen are considered. It is possible to assume hydrogen, deuterium, helium, and tritium atoms (based on Dr. Mizuno and Dr. Kanarev theories) that are formed, diffuse into cavitation bubbles. The plasma is generated during the collapse of the bubble; thus, the quantity of burnt hydrogen determine the volume of generating hydrogen and the impact force caused by hydrogen explosion (noise).There are five main notions, which can determine hydrogen and plasma process: (1) turbine power effect, (2) high shock pressure, (3) crack on turbine parts, (4) impacts effects and (4) the lift of rotating parts. The frequency of the excitation lies in a range from 0.786 to 1.095 Hz.In future, it may be possible to design hydro turbines based on the plasma process that generates hydrogen; or there may exist turbines that rotate with a mixture of hydrogen explosion and water energies

  6. A Diagnosis Method for Rotation Machinery Faults Based on Dimensionless Indexes Combined with K-Nearest Neighbor Algorithm

    Directory of Open Access Journals (Sweden)

    Jianbin Xiong

    2015-01-01

    Full Text Available It is difficult to well distinguish the dimensionless indexes between normal petrochemical rotating machinery equipment and those with complex faults. When the conflict of evidence is too big, it will result in uncertainty of diagnosis. This paper presents a diagnosis method for rotation machinery fault based on dimensionless indexes combined with K-nearest neighbor (KNN algorithm. This method uses a KNN algorithm and an evidence fusion theoretical formula to process fuzzy data, incomplete data, and accurate data. This method can transfer the signals from the petrochemical rotating machinery sensors to the reliability manners using dimensionless indexes and KNN algorithm. The input information is further integrated by an evidence synthesis formula to get the final data. The type of fault will be decided based on these data. The experimental results show that the proposed method can integrate data to provide a more reliable and reasonable result, thereby reducing the decision risk.

  7. Development of a benchmark parameter scan for Higgs bosons in the NMSSM Model and a study of the sensitivity for H{yields}AA{yields}4{tau} in vector boson fusion with the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Rottlaender, Iris

    2008-08-15

    An evaluation of the discovery potential for NMSSM Higgs bosons of the ATLAS experiment at the LHC is presented. For this purpose, seven two-dimensional benchmark planes in the six-dimensional parameter space of the NMSSM Higgs sector are defined. These planes include different types of phenomenology for which the discovery of NMSSM Higgs bosons is especially challenging and which are considered typical for the NMSSM. They are subsequently used to give a detailed evaluation of the Higgs boson discovery potential based on Monte Carlo studies from the ATLAS collaboration. Afterwards, the possibility of discovering NMSSM Higgs bosons via the H{sub 1}{yields}A{sub 1}A{sub 1}{yields}4{tau}{yields}4{mu}+8{nu} decay chain and with the vector boson fusion production mode is investigated. A particular emphasis is put on the mass reconstruction from the complex final state. Furthermore, a study of the jet reconstruction performance at the ATLAS experiment which is of crucial relevance for vector boson fusion searches is presented. A good detectability of the so-called tagging jets that originate from the scattered partons in the vector boson fusion process is of critical importance for an early Higgs boson discovery in many models and also within the framework of the NMSSM. (orig.)

  8. Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation

    Directory of Open Access Journals (Sweden)

    Zhiwei Yang

    2017-06-01

    Full Text Available Membrane fusion is one of the most fundamental physiological processes in eukaryotes for triggering the fusion of lipid and content, as well as the neurotransmission. However, the architecture features of neurotransmitter release machinery and interdependent mechanism of synaptic membrane fusion have not been extensively studied. This review article expounds the neuronal membrane fusion processes, discusses the fundamental steps in all fusion reactions (membrane aggregation, membrane association, lipid rearrangement and lipid and content mixing and the probable mechanism coupling to the delivery of neurotransmitters. Subsequently, this work summarizes the research on the fusion process in synaptic transmission, using electron microscopy (EM and molecular simulation approaches. Finally, we propose the future outlook for more exciting applications of membrane fusion involved in synaptic transmission, with the aid of stochastic optical reconstruction microscopy (STORM, cryo-EM (cryo-EM, and molecular simulations.

  9. Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation

    Science.gov (United States)

    Yang, Zhiwei; Gou, Lu; Chen, Shuyu; Li, Na; Zhang, Shengli; Zhang, Lei

    2017-01-01

    Membrane fusion is one of the most fundamental physiological processes in eukaryotes for triggering the fusion of lipid and content, as well as the neurotransmission. However, the architecture features of neurotransmitter release machinery and interdependent mechanism of synaptic membrane fusion have not been extensively studied. This review article expounds the neuronal membrane fusion processes, discusses the fundamental steps in all fusion reactions (membrane aggregation, membrane association, lipid rearrangement and lipid and content mixing) and the probable mechanism coupling to the delivery of neurotransmitters. Subsequently, this work summarizes the research on the fusion process in synaptic transmission, using electron microscopy (EM) and molecular simulation approaches. Finally, we propose the future outlook for more exciting applications of membrane fusion involved in synaptic transmission, with the aid of stochastic optical reconstruction microscopy (STORM), cryo-EM (cryo-EM), and molecular simulations. PMID:28638320

  10. Electrostatic Architecture of the Infectious Salmon Anemia Virus (ISAV) Core Fusion Protein Illustrates a Carboxyl-Carboxylate pH Sensor.

    Science.gov (United States)

    Cook, Jonathan D; Soto-Montoya, Hazel; Korpela, Markus K; Lee, Jeffrey E

    2015-07-24

    Segment 5, ORF 1 of the infectious salmon anemia virus (ISAV) genome, encodes for the ISAV F protein, which is responsible for viral-host endosomal membrane fusion during a productive ISAV infection. The entry machinery of ISAV is composed of a complex of the ISAV F and ISAV hemagglutinin esterase (HE) proteins in an unknown stoichiometry prior to receptor engagement by ISAV HE. Following binding of the receptor to ISAV HE, dissociation of the ISAV F protein from HE, and subsequent endocytosis, the ISAV F protein resolves into a fusion-competent oligomeric state. Here, we present a 2.1 Å crystal structure of the fusion core of the ISAV F protein determined at low pH. This structure has allowed us to unambiguously demonstrate that the ISAV entry machinery exhibits typical class I viral fusion protein architecture. Furthermore, we have determined stabilizing factors that accommodate the pH-dependent mode of ISAV transmission, and our structure has allowed the identification of a central coil that is conserved across numerous and varied post-fusion viral glycoprotein structures. We then discuss a mechanistic model of ISAV fusion that parallels the paramyxoviral class I fusion strategy wherein attachment and fusion are relegated to separate proteins in a similar fashion to ISAV fusion. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. Higgs production in vector boson fusion in the H{yields} {tau}{tau} {yields} ll + 4{nu} final state with ATLAS. A sensitivity study

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Martin

    2011-05-15

    A study of the expected sensitivity of the ATLAS experiment to discover the Standard Model Higgs boson produced via vector boson fusion (VBF) and its decay to H{yields} {tau}{tau} {yields} ll + 4{nu} is presented. The study is based on simulated proton-proton collisions at a centre-of-mass energy of 14 TeV. For the rst time the discovery potential is evaluated in the presence of additional proton-proton interactions (pile-up) to the process of interest in a complete and consistent way. Special emphasis is placed on the development of background estimation techniques to extract the main background processes Z{yields} {tau}{tau} and t anti t production using data. The t anti t background is estimated using a control sample selected with the VBF analysis cuts and the inverted b-jet veto. The dominant background process Z {yields} {tau}{tau} is estimated using Z{yields} {mu}{mu} events. Replacing the muons of the Z{yields} {mu}{mu} event with simulated {tau}-leptons, Z {yields} {tau}{tau} events are modelled to high precision. For the replacement of the Z boson decay products a dedicated method based on tracks and calorimeter cells is developed. Without pile-up a discovery potential of 3{sigma} to 3.4{sigma} in the mass range 115 GeV

  12. A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.

    Directory of Open Access Journals (Sweden)

    Matthew C Clifton

    Full Text Available Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as well as five ligand-bound structures. The ability to obtain fragment-bound structures advances structure-based drug design efforts that, despite considerable effort, had previously been intractable by crystallography. In the ligand-independent crystal form we identify inhibitor binding modes not observed in earlier crystallographic systems. This MBP-MCL1 construct dramatically improves the structural understanding of well-validated MCL1 ligands, and will likely catalyze the structure-based optimization of high affinity MCL1 inhibitors.

  13. Matrix analysis of electrical machinery

    CERN Document Server

    Hancock, N N

    2013-01-01

    Matrix Analysis of Electrical Machinery, Second Edition is a 14-chapter edition that covers the systematic analysis of electrical machinery performance. This edition discusses the principles of various mathematical operations and their application to electrical machinery performance calculations. The introductory chapters deal with the matrix representation of algebraic equations and their application to static electrical networks. The following chapters describe the fundamentals of different transformers and rotating machines and present torque analysis in terms of the currents based on the p

  14. Mitochondrial Fusion Proteins and Human Diseases

    Directory of Open Access Journals (Sweden)

    Michela Ranieri

    2013-01-01

    Full Text Available Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1 and 2 (MFN2, located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1, in the inner membrane. An expanding number of degenerative disorders are associated with mutations in the genes encoding MFN2 and OPA1, including Charcot-Marie-Tooth disease type 2A and autosomal dominant optic atrophy. While these disorders can still be considered rare, defective mitochondrial dynamics seem to play a significant role in the molecular and cellular pathogenesis of more common neurodegenerative diseases, for example, Alzheimer’s and Parkinson’s diseases. This review provides an overview of the basic molecular mechanisms involved in mitochondrial fusion and focuses on the alteration in mitochondrial DNA amount resulting from impairment of mitochondrial dynamics. We also review the literature describing the main disorders associated with the disruption of mitochondrial fusion.

  15. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development.

    Science.gov (United States)

    Abrams, Elliott W; Zhang, Hong; Marlow, Florence L; Kapp, Lee; Lu, Sumei; Mullins, Mary C

    2012-08-03

    To accommodate the large cells following zygote formation, early blastomeres employ modified cell divisions. Karyomeres are one such modification, mitotic intermediates wherein individual chromatin masses are surrounded by nuclear envelope; the karyomeres then fuse to form a single mononucleus. We identified brambleberry, a maternal-effect zebrafish mutant that disrupts karyomere fusion, resulting in formation of multiple micronuclei. As karyomeres form, Brambleberry protein localizes to the nuclear envelope, with prominent puncta evident near karyomere-karyomere interfaces corresponding to membrane fusion sites. brambleberry corresponds to an unannotated gene with similarity to Kar5p, a protein that participates in nuclear fusion in yeast. We also demonstrate that Brambleberry is required for pronuclear fusion following fertilization in zebrafish. Our studies provide insight into the machinery required for karyomere fusion and suggest that specialized proteins are necessary for proper nuclear division in large dividing blastomeres. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. 46 CFR 58.01-50 - Machinery space, noise.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Machinery space, noise. 58.01-50 Section 58.01-50... MACHINERY AND RELATED SYSTEMS General Requirements § 58.01-50 Machinery space, noise. (a) Each machinery space must be designed to minimize the exposure of personnel to noise in accordance with IMO A.468(XII...

  17. Cavitation in Hydraulic Machinery

    Energy Technology Data Exchange (ETDEWEB)

    Kjeldsen, M.

    1996-11-01

    The main purpose of this doctoral thesis on cavitation in hydraulic machinery is to change focus towards the coupling of non-stationary flow phenomena and cavitation. It is argued that, in addition to turbulence, superimposed sound pressure fluctuations can have a major impact on cavitation and lead to particularly severe erosion. For the design of hydraulic devices this finding may indicate how to further limit the cavitation problems. Chapter 1 reviews cavitation in general in the context of hydraulic machinery, emphasizing the initial cavitation event and the role of the water quality. Chapter 2 discusses the existence of pressure fluctuations for situations common in such machinery. Chapter 3 on cavitation dynamics presents an algorithm for calculating the nucleation of a cavity cluster. Chapter 4 describes the equipment used in this work. 53 refs., 55 figs.,10 tabs.

  18. 29 CFR 1910.215 - Abrasive wheel machinery.

    Science.gov (United States)

    2010-07-01

    ... be securely fastened to the spindle and the bearing surface shall run true. When more than one wheel... 29 Labor 5 2010-07-01 2010-07-01 false Abrasive wheel machinery. 1910.215 Section 1910.215 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.215 Abrasive wheel machinery. (a...

  19. Study of the role of complete fusion in the reaction of /sup 48/Ca and /sup 56/Fe with cerium and terbium. [Cross sections, yield curves, tables

    Energy Technology Data Exchange (ETDEWEB)

    Morrissey, D.J.

    1978-05-01

    /sup 48/Ca and /sup 56/Fe beams from the Super HILAC accelerator were used to irradiate thick metal foils of cerium and terbium. Product gamma ray activities were detected offline and individual products were identified by half-life, gamma ray energy and gamma ray abundances. The production cross sections were iteratively fit to charge and mass dispersions to allow correction for parent decay and calculation of mass yields. From the mass yield curves contributions from quasielastic transfer, deep inelastic transfer and complete fusion reaction mechanisms were interred. Complete fusion was made up on contributions from both evaporation residue and fusion-fission products for the /sup 48/Ca induced reactions. However, only fusion-fission products were detected in the /sup 56/Fe induced reactions. Critical angular momenta for fusion were found to be 82 +- 8 h for /sup 48/Ca + /sup 159/Tb and 34 +- 5 h for /sup 56/Fe + /sup 140/Ce, which can be compared with 53 +- 8 h for /sup 12/C + /sup 197/Au (Natowitz, 1970) and 86 +- 5 h for /sup 40/Ar + /sup 165/Ho (Hanappe, 1973). All of these reactions lead to essentially the same compound nucleus and seem to show the dramatic decline in complete fusion for heavy ions larger than /sup 40/Ar. The prediction of this decline was found to be beyond the model calculations of Bass and the critical distance approach of Glas and Mosel.

  20. Strategies for Improving Enterprise Standardization Management of Tropical Crop Machinery

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ There are two categories of tropical crop machinery. One comprises operation machinery that is used for planting, managing and harvesting tropical crops, while the other comprises process machinery for processing tropical crops. Tropical crop machinery is distinguished from other agricultural machinery by the special crops that such machinery cultivates and processes.

  1. Paramyxovirus membrane fusion: Lessons from the F and HN atomic structures

    International Nuclear Information System (INIS)

    Lamb, Robert A.; Paterson, Reay G.; Jardetzky, Theodore S.

    2006-01-01

    Paramyxoviruses enter cells by fusion of their lipid envelope with the target cell plasma membrane. Fusion of the viral membrane with the plasma membrane allows entry of the viral genome into the cytoplasm. For paramyxoviruses, membrane fusion occurs at neutral pH, but the trigger mechanism that controls the viral entry machinery such that it occurs at the right time and in the right place remains to be elucidated. Two viral glycoproteins are key to the infection process-an attachment protein that varies among different paramyxoviruses and the fusion (F) protein, which is found in all paramyxoviruses. For many of the paramyxoviruses (parainfluenza viruses 1-5, mumps virus, Newcastle disease virus and others), the attachment protein is the hemagglutinin/neuraminidase (HN) protein. In the last 5 years, atomic structures of paramyxovirus F and HN proteins have been reported. The knowledge gained from these structures towards understanding the mechanism of viral membrane fusion is described

  2. The Multifaceted Role of SNARE Proteins in Membrane Fusion.

    Science.gov (United States)

    Han, Jing; Pluhackova, Kristyna; Böckmann, Rainer A

    2017-01-01

    Membrane fusion is a key process in all living organisms that contributes to a variety of biological processes including viral infection, cell fertilization, as well as intracellular transport, and neurotransmitter release. In particular, the various membrane-enclosed compartments in eukaryotic cells need to exchange their contents and communicate across membranes. Efficient and controllable fusion of biological membranes is known to be driven by cooperative action of SNARE proteins, which constitute the central components of the eukaryotic fusion machinery responsible for fusion of synaptic vesicles with the plasma membrane. During exocytosis, vesicle-associated v-SNARE (synaptobrevin) and target cell-associated t-SNAREs (syntaxin and SNAP-25) assemble into a core trans-SNARE complex. This complex plays a versatile role at various stages of exocytosis ranging from the priming to fusion pore formation and expansion, finally resulting in the release or exchange of the vesicle content. This review summarizes current knowledge on the intricate molecular mechanisms underlying exocytosis triggered and catalyzed by SNARE proteins. Particular attention is given to the function of the peptidic SNARE membrane anchors and the role of SNARE-lipid interactions in fusion. Moreover, the regulatory mechanisms by synaptic auxiliary proteins in SNARE-driven membrane fusion are briefly outlined.

  3. Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.

    Directory of Open Access Journals (Sweden)

    Marc Liesa

    Full Text Available There is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression.Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1beta is associated with a selective reduction in Mitofusin 2 (Mfn2 expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1beta increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1beta-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1beta increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor alpha (ERRalpha.Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1beta in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2.

  4. Definition of Ignition in Inertial Confinement Fusion

    Science.gov (United States)

    Christopherson, A. R.; Betti, R.

    2017-10-01

    Defining ignition in inertial confinement fusion (ICF) is an unresolved problem. In ICF, a distinction must be made between the ignition of the hot spot and the propagation of the burn wave in the surrounding dense fuel. Burn propagation requires that the hot spot is robustly ignited and the dense shell exhibits enough areal density. Since most of the energy gain comes from burning the dense shell, in a scale of increasing yields, hot-spot ignition comes before high gains. Identifying this transition from hot-spot ignition to burn-wave propagation is key to defining ignition in general terms applicable to all fusion approaches that use solid DT fuel. Ad hoc definitions such as gain = 1 or doubling the temperature are not generally valid. In this work, we show that it is possible to identify the onset of ignition through a unique value of the yield amplification defined as the ratio of the fusion yield including alpha-particle deposition to the fusion yield without alphas. Since the yield amplification is a function of the fractional alpha energy fα =EαEα 2Ehs 2Ehs (a measurable quantity), it appears possible not only to define ignition but also to measure the onset of ignition by the experimental inference of the fractional alpha energy and yield amplification. This material is based upon work supported by the Department of Energy Office of Fusion Energy Services under Award Number DE-FC02-04ER54789 and National Nuclear Security Administration under Award Number DE-NA0001944.

  5. On Development of Agricultural Machinery Operating Service in Chongqing

    Institute of Scientific and Technical Information of China (English)

    Chongjing; TAN; Shi; YANG

    2015-01-01

    Development of agricultural machinery operating service in Chongqing takes on rapid increase in number of service organizations,diversified service methods,improvement in service level,and constant service income. However,there are some problems,including unreasonable composition and small scale of service organization,imbalanced development of four service methods,low service level,and low operating income of agricultural machinery households. To accelerate development of agricultural machinery operating service in Chongqing,it is recommended to take following measures: adjusting subsidy for purchase and operation of agricultural machinery; improving fiscal and taxation and financial system; speeding up infrastructure construction,establishing agricultural machinery information network,and improving organizational form and methods of agricultural machinery operating service.

  6. Machinery Vibration Monitoring Program at the Savannah River Site

    International Nuclear Information System (INIS)

    Potvin, M.M.

    1990-01-01

    The Reactor Maintenance's Machinery Vibration Monitoring Program (MVMP) plays an essential role in ensuring the safe operation of the three Production Reactors at the Westinghouse Savannah River Company (WRSC) Savannah River Site (SRS). This program has increased machinery availability and reduced maintenance cost by the early detection and determination of machinery problems. This paper presents the Reactor Maintenance's Machinery Vibration Monitoring Program, which has been documented based on Electric Power Research Institute's (EPRI) NP-5311, Utility Machinery Monitoring Guide, and some examples of the successes that it has enjoyed

  7. 46 CFR 252.33 - Hull and machinery insurance.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Hull and machinery insurance. 252.33 Section 252.33... Subsidy Rates § 252.33 Hull and machinery insurance. (a) Subsidy items. The fair and reasonable net premium costs (including stamp taxes) of hull and machinery, increased value, excess general average...

  8. A sensitivity study for Higgs boson production in Vector Boson Fusion in the H {yields} {tau}{tau} {yields} lh+3{nu} final state with ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Moeser, Nicolas

    2011-11-15

    For a hypothetical Higgs boson mass between 114.4 GeV and about 135 GeV the production by Vector Boson Fusion and the decay H {yields} {tau}{tau} {yields} lh + 3{nu} is one of the most promising discovery channels at the LHC. In this thesis, a study of the expected sensitivity of the ATLAS detector for this channel at a centre-of-mass energy of 14 TeV is presented. For the first time, this study includes a full treatment of additional proton-proton interactions, so-called pile-up. The presence of pile-up significantly affects the signal selection efficiency and leads to a deterioration of the reconstructed Higgs boson mass, which is used as a discriminating observable. Two methods have been developed to estimate the dominant background processes from data. By replacing the muons in Z {yields} {mu}{mu} events with simulated {tau} lepton decays, Z {yields} {tau}{tau} events can be modelled with high precision. The non-resonant background, t anti t production and W+jets, is estimated by selecting events where lepton and hadronic {tau} decay have the same electric charge. Assuming a dataset corresponding to an integrated luminosity of 30 fb{sup -1}, an expected signal significance between 3.0 {sigma} and 4.4{sigma} is obtained for a Higgs boson mass between 115 GeV and 135 GeV. The expected significance decreases to 1.6-2.0{sigma} in the presence of pile-up. (orig.)

  9. Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion

    International Nuclear Information System (INIS)

    Wu Liguo; Hutt-Fletcher, Lindsey M.

    2007-01-01

    Cell fusion mediated by Epstein-Barr virus requires three conserved glycoproteins, gB and gHgL, but activation is cell type specific. B cell fusion requires interaction between MHC class II and a fourth virus glycoprotein, gp42, which complexes non-covalently with gHgL. Epithelial cell fusion requires interaction between gHgL and a novel epithelial cell coreceptor and is blocked by excess gp42. We show here that gp42 interacts directly with gH and that point mutations in the region of gH recognized by an antibody that differentially inhibits epithelial and B cell fusion significantly impact both the core fusion machinery and cell-specific events. Substitution of alanine for glycine at residue 594 completely abrogates fusion with either B cells or epithelial cells. Substitution of alanine for glutamic acid at residue 595 reduces fusion with epithelial cells, greatly enhances fusion with B cells and allows low levels of B cell fusion even in the absence of gL

  10. 46 CFR 282.23 - Hull and machinery insurance.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Hull and machinery insurance. 282.23 Section 282.23... COMMERCE OF THE UNITED STATES Calculation of Subsidy Rates § 282.23 Hull and machinery insurance. (a) Subsidy items. The fair and reasonable net premium costs (including stamp taxes) of hull and machinery...

  11. Decomposition of incomplete fusion

    International Nuclear Information System (INIS)

    Sobotka, L.B.; Sarantities, D.G.; Stracener, D.W.; Majka, Z.; Abenante, V.; Semkow, T.M.; Hensley, D.C.; Beene, J.R.; Halbert, M.L.

    1989-01-01

    The velocity distribution of fusion-like products formed in the reaction 701 MeV 28 Si+ 100 Mo is decomposed into 26 incomplete fusion channels. The momentum deficit of the residue per nonevaporative mass unit is approximately equal to the beam momentum per nucleon. The yields of the incomplete fusion channels correlate with the Q-value for projectile fragmentation rather than that for incomplete fusion. The backward angle multiplicities of light particles and heavy ions increase with momentum transfer, however, the heavy ion multiplicities also depend on the extent of the fragmentation of the incomplete fusion channel. These data indicate that at fixed linear momentum transfer, increased fragmentation of the unfused component is related to a reduced transferred angular momentum. 22 refs., 6 figs., 1 tab

  12. 46 CFR 97.30-5 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Accidents to machinery. 97.30-5 Section 97.30-5 Shipping... Reports of Accidents, Repairs, and Unsafe Equipment § 97.30-5 Accidents to machinery. (a) In the event of an accident to a boiler, unfired pressure vessel, or machinery tending to render the further use of...

  13. 46 CFR 196.30-5 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Accidents to machinery. 196.30-5 Section 196.30-5... Reports of Accidents, Repairs, and Unsafe Equipment § 196.30-5 Accidents to machinery. (a) In the event of an accident to a boiler, unfired pressure vessel, or machinery tending to render the further use of...

  14. Enhancing Ignition Probability and Fusion Yield in NIF Indirect Drive Targets with Applied Magnetic Fields

    Science.gov (United States)

    Perkins, L. John; Logan, B. Grant; Ho, Darwin; Zimmerman, George; Rhodes, Mark; Blackfield, Donald; Hawkins, Steven

    2017-10-01

    Imposed magnetic fields of tens of Tesla that increase to greater than 10 kT (100 MGauss) under capsule compression may relax conditions for ignition and propagating burn in indirect-drive ICF targets. This may allow attainment of ignition, or at least significant fusion energy yields, in presently-performing ICF targets on the National Ignition Facility that today are sub-marginal for thermonuclear burn through adverse hydrodynamic conditions at stagnation. Results of detailed 2D radiation-hydrodynamic-burn simulations applied to NIF capsule implosions with low-mode shape perturbations and residual kinetic energy loss indicate that such compressed fields may increase the probability for ignition through range reduction of fusion alpha particles, suppression of electron heat conduction and stabilization of higher-mode RT instabilities. Optimum initial applied fields are around 50 T. Off-line testing has been performed of a hohlraum coil and pulsed power supply that could be integrated on NIF; axial fields of 58T were obtained. Given the full plasma structure at capsule stagnation may be governed by 3-D resistive MHD, the formation of closed magnetic field lines might further augment ignition prospects. Experiments are now required to assess the potential of applied magnetic fields to NIF ICF ignition and burn. Work performed under auspices of U.S. DOE by LLNL under Contract DE-AC52-07NA27344.

  15. Effect of projectile structure on evaporation residue yields in incomplete fusion reactions

    CERN Document Server

    Babu, K S; Sudarshan, K; Shrivastava, B D; Goswami, A; Tomar, B S

    2003-01-01

    The excitation functions of heavy residues, representing complete and incomplete fusion products, produced in the reaction of sup 1 sup 2 C and sup 1 sup 3 C on sup 1 sup 8 sup 1 Ta have been measured over the projectile energy range of 5 to 6.5 MeV/nucleon by the recoil catcher method and off-line gamma-ray spectrometry. Comparison of the measured excitation functions with those calculated using the PACE2 code based on the statistical model revealed the occurrence of incomplete fusion reactions in the formation of alpha emission products. The fraction of incomplete fusion cross sections in the sup 1 sup 2 C + sup 1 sup 8 sup 1 Ta reaction was found to be higher, by a factor of approx 2, than that in the sup 1 sup 3 C + sup 1 sup 8 sup 1 Ta reaction. The results have been discussed in terms of the effect of alpha cluster structure of the projectile on incomplete fusion reactions.

  16. Low cost, high yield IFE reactors: Revisiting Velikhov's vaporizing blankets

    International Nuclear Information System (INIS)

    Logan, B.G.

    1992-01-01

    The performance (efficiency and cost) of IFE reactors using MHD conversion is explored for target blanket shells of various materials vaporized and ionized by high fusion yields (5 to 500 GJ). A magnetized, prestressed reactor chamber concept is modeled together with previously developed models for the Compact Fusion Advanced Rankine II (CFARII) MHD Balance-of-Plant (BoP). Using conservative 1-D neutronics models, high fusion yields (20 to 80 GJ) are found necessary to heat Flibe, lithium, and lead-lithium blankets to MHD plasma temperatures, at initial solid thicknesses sufficient to capture most of the fusion yield. Advanced drivers/targets would need to be developed to achieve a ''Bang per Buck'' figure-of-merit approx-gt 20 to 40 joules yield per driver $ for this scheme to be competitive with these blanket materials. Alternatively, more realistic neutronics models and better materials such as lithium hydride may lower the minimum required yields substantially. The very low CFARII BoP costs (contributing only 3 mills/kWehr to CoE) allows this type of reactor, given sufficient advances that non-driver costs dominate, to ultimately produce electricity at a much lower cost than any current nuclear plant

  17. Realizing Technologies for Magnetized Target Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Wurden, Glen A. [Los Alamos National Laboratory

    2012-08-24

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  18. Exponential yield sensitivity to long-wavelength asymmetries in three-dimensional simulations of inertial confinement fusion capsule implosions

    Energy Technology Data Exchange (ETDEWEB)

    Haines, Brian M., E-mail: bmhaines@lanl.gov [Los Alamos National Laboratory, MS T087, Los Alamos, New Mexico 87545 (United States)

    2015-08-15

    In this paper, we perform a series of high-resolution 3D simulations of an OMEGA-type inertial confinement fusion (ICF) capsule implosion with varying levels of initial long-wavelength asymmetries in order to establish the physical energy loss mechanism for observed yield degradation due to long-wavelength asymmetries in symcap (gas-filled capsule) implosions. These simulations demonstrate that, as the magnitude of the initial asymmetries is increased, shell kinetic energy is increasingly retained in the shell instead of being converted to fuel internal energy. This is caused by the displacement of fuel mass away from and shell material into the center of the implosion due to complex vortical flows seeded by the long-wavelength asymmetries. These flows are not fully turbulent, but demonstrate mode coupling through non-linear instability development during shell stagnation and late-time shock interactions with the shell interface. We quantify this effect by defining a separation lengthscale between the fuel mass and internal energy and show that this is correlated with yield degradation. The yield degradation shows an exponential sensitivity to the RMS magnitude of the long-wavelength asymmetries. This strong dependence may explain the lack of repeatability frequently observed in OMEGA ICF experiments. In contrast to previously reported mechanisms for yield degradation due to turbulent instability growth, yield degradation is not correlated with mixing between shell and fuel material. Indeed, an integrated measure of mixing decreases with increasing initial asymmetry magnitude due to delayed shock interactions caused by growth of the long-wavelength asymmetries without a corresponding delay in disassembly.

  19. Inertial confinement fusion

    International Nuclear Information System (INIS)

    Nuckolls, J.H.; Wood, L.L.

    1988-01-01

    Edward Teller has been a strong proponent of harnessing nuclear explosions for peaceful purposes. There are two approaches: Plowshare, which utilizes macro- explosions, and inertial confinement fusion, which utilizes microexplosions. The development of practical fusion power plants is a principal goal of the inertial program. It is remarkable that Teller's original thermonuclear problem, how to make super high yield nuclear explosions, and the opposite problem, how to make ultra low yield nuclear explosions, may both be solved by Teller's radiation implosion scheme. This paper reports on the essential physics of these two thermonuclear domains, which are separated by nine orders of magnitude in yield, provided by Teller's similarity theorem and its exceptions. Higher density makes possible thermonuclear burn of smaller masses of fuel. The leverage is high: the scale of the explosion diminishes with the square of the increase in density. The extraordinary compressibility of matter, first noticed by Teller during the Los Alamos atomic bomb program, provides an almost incredible opportunity to harness fusion. The energy density of thermonuclear fuels isentropically compressed to super high-- -densities---even to ten thousand times solid density---is small compared to the energy density at thermonuclear ignition temperatures. In small masses of fuel imploded to these super high matter densities, the energy required to achieve ignition may be greatly reduced by exploiting thermonuclear propagation from a relatively small hot spot

  20. Hormone activities and the cell cycle machinery in immunity-triggered growth inhibition.

    Science.gov (United States)

    Reitz, M U; Gifford, M L; Schäfer, P

    2015-04-01

    Biotic stress and diseases caused by pathogen attack pose threats in crop production and significantly reduce crop yields. Enhancing immunity against pathogens is therefore of outstanding importance in crop breeding. However, this must be balanced, as immune activation inhibits plant growth. This immunity-coupled growth trade-off does not support resistance but is postulated to reflect the reallocation of resources to drive immunity. There is, however, increasing evidence that growth-immunity trade-offs are based on the reconfiguration of hormone pathways, shared by growth and immunity signalling. Studies in roots revealed the role of hormones in orchestrating growth across different cell types, with some hormones showing a defined cell type-specific activity. This is apparently highly relevant for the regulation of the cell cycle machinery and might be part of the growth-immunity cross-talk. Since plants are constantly exposed to Immuno-activating microbes under agricultural conditions, the transition from a growth to an immunity operating mode can significantly reduce crop yield and can conflict our efforts to generate next-generation crops with improved yield under climate change conditions. By focusing on roots, we outline the current knowledge of hormone signalling on the cell cycle machinery to explain growth trade-offs induced by immunity. By referring to abiotic stress studies, we further introduce how root cell type-specific hormone activities might contribute to growth under immunity and discuss the feasibility of uncoupling the growth-immunity cross-talk. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  1. Inertial fusion with hypervelocity impact

    International Nuclear Information System (INIS)

    Olariu, S.

    1998-01-01

    The physics of the compression and ignition processes in inertial fusion is to a certain extent independent of the nature of the incident energy pulse. The present strategy in the field of inertial fusion is to study several alternatives of deposition of the incident energy, and, at the same time, of conducting studies with the aid of available incident laser pulses. In a future reactor based on inertial fusion, the laser beams may be replaced by ion beams, which have a better energy efficiency. The main projects in the field of inertial fusion are the National Ignition Facility (NIF) in USA, Laser Megajoule (LMJ) in France, Gekko XII in Japan and Iskra V in Russia. NIF will be constructed at Lawrence Livermore National Laboratory, in California. LMJ will be constructed near Bordeaux. In the conventional approach to inertial confinement fusion, both the high-density fuel mass and the hot central spot are supposed to be produced by the deposition of the driver energy in the outer layers of the fuel capsule. Alternatively, the driver energy could be used only to produce the radial compression of the fuel capsule to high densities but relatively low temperatures, while the ignition of fusion reactions in the compressed capsule should be effected by a synchronized hypervelocity impact. Using this arrangement, it was supposed that a 54 μm projectile is incident with a velocity of 3 x 10 6 m s -1 upon a large-yield deuterium-tritium target at rest. The collision of the incident projectile and of the large-yield target takes place inside a high-Z cavity. A laser or heavy-ion pulse is converted at the walls of the cavity into X-rays, which compresses the incident projectile and the large-yield target in high-density states. The laser pulse and the movement of the incident projectile are synchronized such that the collision should take place when the densities are the largest. The collision converts the kinetic energy of the incident projectile into thermal energy, the

  2. Sensitivity of the ATLAS experiment to discover the decay H{yields} {tau}{tau} {yields}ll+4{nu} of the Standard Model Higgs Boson produced in vector boson fusion

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Martin

    2011-05-17

    A study of the expected sensitivity of the ATLAS experiment to discover the Standard Model Higgs boson produced via vector boson fusion (VBF) and its decay to H{yields} {tau}{tau}{yields} ll+4{nu} is presented. The study is based on simulated proton-proton collisions at a centre-of-mass energy of 14 TeV. For the first time the discovery potential is evaluated in the presence of additional proton-proton interactions (pile-up) to the process of interest in a complete and consistent way. Special emphasis is placed on the development of background estimation techniques to extract the main background processes Z{yields}{tau}{tau} and t anti t production using data. The t anti t background is estimated using a control sample selected with the VBF analysis cuts and the inverted b-jet veto. The dominant background process Z{yields}{tau}{tau} is estimated using Z{yields}{mu}{mu} events. Replacing the muons of the Z{yields}{mu}{mu} event with simulated {tau}-leptons, Z{yields}{tau}{tau} events are modelled to high precision. For the replacement of the Z boson decay products a dedicated method based on tracks and calorimeter cells is developed. Without pile-up a discovery potential of 3{sigma} to 3.4{sigma} in the mass range 115 GeV

  3. Z-pinch driven fusion energy

    International Nuclear Information System (INIS)

    Slutz, Stephen A.; Olson, Craig L.; Rochau, Gary E.; Dezon, Mark S.; Peterson, P.F.; Degroot, J.S.; Jensen, N.; Miller, G.

    2000-01-01

    The Z machine at Sandia National Laboratories (SNL) is the most powerful multi-module synchronized pulsed-power accelerator in the world. Rapid development of z-pinch loads on Z has led to outstanding progress in the last few years, resulting in radiative powers of up to 280 TW in 4 ns and a total radiated x-ray energy of 1.8 MJ. The present goal is to demonstrate single-shot, high-yield fusion capsules. Pulsed power is a robust and inexpensive technology, which should be well suited for Inertial Fusion Energy, but a rep-rated capability is needed. Recent developments have led to a viable conceptual approach for a rep-rated z-pinch power plant for IFE. This concept exploits the advantages of going to high yield (a few GJ) at low rep-rate (approximately 0.1 Hz), and using a Recyclable Transmission Line (RTL) to provide the necessary standoff between the fusion target and the power plant chamber. In this approach, a portion of the transmission line near the capsule is replaced after each shot. The RTL should be constructed of materials that can easily be separated from the liquid coolant stream and refabricated for a subsequent shots. One possibility is that most of the RTL is formed by casting FLiBe, a salt composed of fluorine, lithium, and beryllium, which is an attractive choice for the reactor coolant, with chemically compatible lead or tin on the surface to provide conductivity. The authors estimate that fusion yields greater than 1 GJ will be required for efficient generation of electricity. Calculations indicate that the first wall will have an acceptable lifetime with these high yields if blast mitigation techniques are used. Furthermore, yields above 5 GJ may allow the use of a compact blanket direct conversion scheme

  4. A tethering complex drives the terminal stage of SNARE-dependent membrane fusion

    Science.gov (United States)

    D'Agostino, Massimo; Risselada, Herre Jelger; Lürick, Anna; Ungermann, Christian; Mayer, Andreas

    2017-11-01

    Membrane fusion in eukaryotic cells mediates the biogenesis of organelles, vesicular traffic between them, and exo- and endocytosis of important signalling molecules, such as hormones and neurotransmitters. Distinct tasks in intracellular membrane fusion have been assigned to conserved protein systems. Tethering proteins mediate the initial recognition and attachment of membranes, whereas SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) protein complexes are considered as the core fusion engine. SNARE complexes provide mechanical energy to distort membranes and drive them through a hemifusion intermediate towards the formation of a fusion pore. This last step is highly energy-demanding. Here we combine the in vivo and in vitro fusion of yeast vacuoles with molecular simulations to show that tethering proteins are critical for overcoming the final energy barrier to fusion pore formation. SNAREs alone drive vacuoles only into the hemifused state. Tethering proteins greatly increase the volume of SNARE complexes and deform the site of hemifusion, which lowers the energy barrier for pore opening and provides the driving force. Thereby, tethering proteins assume a crucial mechanical role in the terminal stage of membrane fusion that is likely to be conserved at multiple steps of vesicular traffic. We therefore propose that SNAREs and tethering proteins should be considered as a single, non-dissociable device that drives fusion. The core fusion machinery may then be larger and more complex than previously thought.

  5. Propagation of nuclear data uncertainties for fusion power measurements

    Directory of Open Access Journals (Sweden)

    Sjöstrand Henrik

    2017-01-01

    Full Text Available Neutron measurements using neutron activation systems are an essential part of the diagnostic system at large fusion machines such as JET and ITER. Nuclear data is used to infer the neutron yield. Consequently, high-quality nuclear data is essential for the proper determination of the neutron yield and fusion power. However, uncertainties due to nuclear data are not fully taken into account in uncertainty analysis for neutron yield calibrations using activation foils. This paper investigates the neutron yield uncertainty due to nuclear data using the so-called Total Monte Carlo Method. The work is performed using a detailed MCNP model of the JET fusion machine; the uncertainties due to the cross-sections and angular distributions in JET structural materials, as well as the activation cross-sections in the activation foils, are analysed. It is found that a significant contribution to the neutron yield uncertainty can come from uncertainties in the nuclear data.

  6. 46 CFR 109.205 - Inspection of boilers and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Inspection of boilers and machinery. 109.205 Section 109... OPERATIONS Tests, Drills, and Inspections § 109.205 Inspection of boilers and machinery. The chief engineer or engineer in charge, before he assumes charge of the boilers and machinery of a unit shall inspect...

  7. 46 CFR 185.208 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Accidents to machinery. 185.208 Section 185.208 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Marine Casualties and Voyage Records § 185.208 Accidents to machinery. The owner, managing...

  8. 46 CFR 122.208 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Accidents to machinery. 122.208 Section 122.208 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... Voyage Records § 122.208 Accidents to machinery. The owner, managing operator, or master shall report...

  9. 29 CFR 1915.164 - Ship's propulsion machinery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Ship's propulsion machinery. 1915.164 Section 1915.164 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) OCCUPATIONAL SAFETY AND HEALTH STANDARDS FOR SHIPYARD EMPLOYMENT Ship's Machinery and Piping Systems § 1915.164 Ship's...

  10. Measurement of inertial confinement fusion reaction rate

    International Nuclear Information System (INIS)

    Peng Xiaoshi; Wang Feng; Tang Daorun; Liu Shenye; Huang Tianxuan; Liu Yonggang; Xu Tao; Chen Ming; Mei Yu

    2011-01-01

    Fusion reaction rate is an important parameter for measuring compression during the implosion in inertial confinement fusion experiment. We have developed a system for fusion reaction history measurement with high temporal resolution. The system is composed of plastic scintillator and nose cone, optical system and streak camera. We have applied this system on the SG-III prototype for fusion reaction rate measuring. For the first time, fusion reaction rate history have been measured for deuterium-tritium filled targets with neutrons yields about 10 10 . We have analyzed possible influence factor during fusion reaction rate measuring. It indicates that the instrument measures fusion reaction bang time at temporal resolutions as low as 30 ps.(authors)

  11. Vibration vector monitoring of rotating machinery: A predictive/preventative maintenance technique

    International Nuclear Information System (INIS)

    Humes, B.R.

    1990-01-01

    Monitoring of overall vibration amplitudes to indicate machinery faults is a standard practice in most industries. The appearance of shaft cracks in machines retrofitted for extended life have prompted development of higher levels of machinery monitoring. Part 1 of this paper discusses vibration vector monitoring for machinery malfunction prediction and failure prevention. Machinery faults which can be diagnosed by this type of monitoring, such as rotor rubs, loose parts, shaft cracks, ..., are presented along with their most common characteristics. The newest, most effective methods of permanent machinery monitoring are presented and critiqued. An extensive case history is presented in Part 2 in which a potentially disastrous machinery fault was predicted using vibration vector monitoring and analysis. The addition of vector monitoring to the normal, overall vibration monitoring proved more effective in diagnosing the machinery fault and predicting impending failure

  12. Selectable high-yield recombinant protein production in human cells using a GFP/YFP nanobody affinity support.

    Science.gov (United States)

    Schellenberg, Matthew J; Petrovich, Robert M; Malone, Christine C; Williams, R Scott

    2018-03-25

    Recombinant protein expression systems that produce high yields of pure proteins and multi-protein complexes are essential to meet the needs of biologists, biochemists, and structural biologists using X-ray crystallography and cryo-electron microscopy. An ideal expression system for recombinant human proteins is cultured human cells where the correct translation and chaperone machinery are present. However, compared to bacterial expression systems, human cell cultures present several technical challenges to their use as an expression system. We developed a method that utilizes a YFP fusion-tag to generate recombinant proteins using suspension-cultured HEK293F cells. YFP is a dual-function tag that enables direct visualization and fluorescence-based selection of high expressing clones for and rapid purification using a high-stringency, high-affinity anti-GFP/YFP nanobody support. We demonstrate the utility of this system by expressing two large human proteins, TOP2α (340 KDa dimer) and a TOP2β catalytic core (260 KDa dimer). This robustly and reproducibly yields >10 mg/L liter of cell culture using transient expression or 2.5 mg/L using stable expression. Published 2018. This article is a US Government work and is in the public domain in the USA.

  13. Fusion reactors and the environment

    International Nuclear Information System (INIS)

    Hancox, R.

    1990-04-01

    Fusion power, based on the nuclear fusion of light elements to yield a net gain of energy, has the potential to extend the world's resources in a way which is environmentally attractive. Nevertheless, the easiest route to fusion - the reaction between deuterium and tritium - involves hazards from the use of tritium and the neutron activation of the structural materials. These hazards have been considered on the basis of simple conceptual reactor designs, both in relation to normal operation and decommissioning and to potential accident situations. Results from several studies are reviewed and suggest that fusion reactors appear to have an inherently lower environmental impact than fission reactors. However, the realization of this potential has yet to be demonstrated. (author)

  14. Risk assessments and safe machinery ensuring compliance with the EU directives

    CERN Document Server

    Jespen, Torben

    2016-01-01

    This book describes the prerequisites for the placing on the market and the safe use of machinery in compliance with the relevant EU Directives, especially the Machinery Directive 2006/42. It provides readers with high-level knowledge concerning the Essential Health and Safety Requirements (EHSR) that machinery must fulfill. The approach and principles of the Machinery Directive were most recently made worldwide acknowledged in the ILO code of practice on safe machinery, released in 2013. The book addresses that code, as well as providing valuable insight into other EU Product and Workplace legislation. Focusing on the key aspect of safe machinery, the “machinery safety risk assessment”, which allows readers to better understand the more difficult aspects of risk assessments, the book equips readers to tackle problems at the manufacturing stage and in different use scenarios, introducing them to risk reduction techniques and functional safety aspects.

  15. Scaling laws for inertial confinement fusion

    International Nuclear Information System (INIS)

    Brueckner, K.A.

    1978-01-01

    The fusion yield due to a spherically expanding burning front in a compressed fuel pellet is obtained. The pellet gain and beam energy for a laser system and an ion or electron beam driven system are compared. The results suggest an interesting possibility for heavy-ion fusion with driver parameters far below those usually considered

  16. Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM.

    Science.gov (United States)

    Khosravi, Mojtaba; Bringolf, Fanny; Röthlisberger, Silvan; Bieringer, Maria; Schneider-Schaulies, Jürgen; Zurbriggen, Andreas; Origgi, Francesco; Plattet, Philippe

    2016-02-01

    Measles virus (MeV) and canine distemper virus (CDV) possess tetrameric attachment proteins (H) and trimeric fusion proteins, which cooperate with either SLAM or nectin 4 receptors to trigger membrane fusion for cell entry. While the MeV H-SLAM cocrystal structure revealed the binding interface, two distinct oligomeric H assemblies were also determined. In one of the conformations, two SLAM units were sandwiched between two discrete H head domains, thus spotlighting two binding interfaces ("front" and "back"). Here, we investigated the functional relevance of both interfaces in activating the CDV membrane fusion machinery. While alanine-scanning mutagenesis identified five critical regulatory residues in the front H-binding site of SLAM, the replacement of a conserved glutamate residue (E at position 123, replaced with A [E123A]) led to the most pronounced impact on fusion promotion. Intriguingly, while determination of the interaction of H with the receptor using soluble constructs revealed reduced binding for the identified SLAM mutants, no effect was recorded when physical interaction was investigated with the full-length counterparts of both molecules. Conversely, although mutagenesis of three strategically selected residues within the back H-binding site of SLAM did not substantially affect fusion triggering, nevertheless, the mutants weakened the H-SLAM interaction recorded with the membrane-anchored protein constructs. Collectively, our findings support a mode of binding between the attachment protein and the V domain of SLAM that is common to all morbilliviruses and suggest a major role of the SLAM residue E123, located at the front H-binding site, in triggering the fusion machinery. However, our data additionally support the hypothesis that other microdomain(s) of both glycoproteins (including the back H-binding site) might be required to achieve fully productive H-SLAM interactions. A complete understanding of the measles virus and canine distemper virus

  17. Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol

    Energy Technology Data Exchange (ETDEWEB)

    Kadam, Rameshwar U.; Wilson, Ian A.

    2016-12-21

    The broad-spectrum antiviral drug Arbidol shows efficacy against influenza viruses by targeting the hemagglutinin (HA) fusion machinery. However, the structural basis of the mechanism underlying fusion inhibition by Arbidol has remained obscure, thereby hindering its further development as a specific and optimized influenza therapeutic. We determined crystal structures of Arbidol in complex with influenza virus HA from pandemic 1968 H3N2 and recent 2013 H7N9 viruses. Arbidol binds in a hydrophobic cavity in the HA trimer stem at the interface between two protomers. This cavity is distal to the conserved epitope targeted by broadly neutralizing stem antibodies and is ~16 Å from the fusion peptide. Arbidol primarily makes hydrophobic interactions with the binding site but also induces some conformational rearrangements to form a network of inter- and intraprotomer salt bridges. By functioning as molecular glue, Arbidol stabilizes the prefusion conformation of HA that inhibits the large conformational rearrangements associated with membrane fusion in the low pH of the endosome. This unique binding mode compared with the small-molecule inhibitors of other class I fusion proteins enhances our understanding of how small molecules can function as fusion inhibitors and guides the development of broad-spectrum therapeutics against influenza virus.

  18. 46 CFR 182.465 - Ventilation of spaces containing diesel machinery.

    Science.gov (United States)

    2010-10-01

    ... furnish natural or powered supply and exhaust ventilation. The total inlet area and the total outlet area... 46 Shipping 7 2010-10-01 2010-10-01 false Ventilation of spaces containing diesel machinery. 182... Ventilation of spaces containing diesel machinery. (a) A space containing diesel machinery must be fitted with...

  19. Diagnostic technique for measuring fusion reaction rate for inertial confinement fusion experiments at Shen Guang-III prototype laser facility

    International Nuclear Information System (INIS)

    Wang Feng; Peng Xiao-Shi; Liu Shen-Ye; Xu Tao; Kang Dong-Guo

    2013-01-01

    A study is conducted using a two-dimensional simulation program (Lared-s) with the goal of developing a technique to evaluate the effect of Rayleigh-Taylor growth in a neutron fusion reaction region. Two peaks of fusion reaction rate are simulated by using a two-dimensional simulation program (Lared-s) and confirmed by the experimental results. A neutron temporal diagnostic (NTD) system is developed with a high temporal resolution of ∼ 30 ps at the Shen Guang-III (SG-III) prototype laser facility in China, to measure the fusion reaction rate history. With the shape of neutron reaction rate curve and the spherical harmonic function in this paper, the degree of Rayleigh-Taylor growth and the main source of the neutron yield in our experiment can be estimated qualitatively. This technique, including the diagnostic system and the simulation program, may provide important information for obtaining a higher neutron yield in implosion experiments of inertial confinement fusion

  20. Measurement of the X and gamma radiation after muon-catalyzed pd-, dd-, and dt-fusion

    International Nuclear Information System (INIS)

    Bossy, H.

    1987-01-01

    The muonic X radiation emitted after muon-catalyzed fusion of two hydrogen nuclei has been measured for the fusion reactions of pd, dd, and dt (p=proton, d=deuteron, t=triton). The quantum yields (per fusion) of the μHe(2-1) transition were evaluated to be 3.2(4)% (pd fusion), 1.6(2)% (dd fusion), and 0.21(5)% (dt fusion, preliminary value). The intensity ratios of the transitions μHe(3-1)/μHe(2-1) were found to be 0.052(5) (pd fusion) and 0.13(2) (dd fusion). The investigation of the gamma radiation intensities for pd fusion yielded excitement probabilities of the μHe atom. (orig.) [de

  1. Cell fusion in tumor progression: the isolation of cell fusion products by physical methods

    Directory of Open Access Journals (Sweden)

    Vincitorio Massimo

    2011-09-01

    Full Text Available Abstract Background Cell fusion induced by polyethylene glycol (PEG is an efficient but poorly controlled procedure for obtaining somatic cell hybrids used in gene mapping, monoclonal antibody production, and tumour immunotherapy. Genetic selection techniques and fluorescent cell sorting are usually employed to isolate cell fusion products, but both procedures have several drawbacks. Results Here we describe a simple improvement in PEG-mediated cell fusion that was obtained by modifying the standard single-step procedure. We found that the use of two PEG undertreatments obtains a better yield of cell fusion products than the standard method, and most of these products are bi- or trinucleated polykaryocytes. Fusion rate was quantified using fluorescent cell staining microscopy. We used this improved cell fusion and cell isolation method to compare giant cells obtained in vitro and giant cells obtained in vivo from patients with Hodgkin's disease and erythroleukemia. Conclusions In the present study we show how to improve PEG-mediated cell fusion and that cell separation by velocity sedimentation offers a simple alternative for the efficient purification of cell fusion products and to investigate giant cell formation in tumor development.

  2. The Research of Computer Aided Farm Machinery Designing Method Based on Ergonomics

    Science.gov (United States)

    Gao, Xiyin; Li, Xinling; Song, Qiang; Zheng, Ying

    Along with agricultural economy development, the farm machinery product type Increases gradually, the ergonomics question is also getting more and more prominent. The widespread application of computer aided machinery design makes it possible that farm machinery design is intuitive, flexible and convenient. At present, because the developed computer aided ergonomics software has not suitable human body database, which is needed in view of farm machinery design in China, the farm machinery design have deviation in ergonomics analysis. This article puts forward that using the open database interface procedure in CATIA to establish human body database which aims at the farm machinery design, and reading the human body data to ergonomics module of CATIA can product practical application virtual body, using human posture analysis and human activity analysis module to analysis the ergonomics in farm machinery, thus computer aided farm machinery designing method based on engineering can be realized.

  3. Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design.

    Science.gov (United States)

    Cai, Lifeng; Gochin, Miriam; Liu, Keliang

    2011-12-01

    Human immunodeficiency virus type 1 (HIV-1), the pathogen of acquired immunodeficiency syndrome (AIDS), causes ~2 millions death every year and still defies an effective vaccine. HIV-1 infects host cells through envelope protein - mediated virus-cell fusion. The transmembrane subunit of envelope protein, gp41, is the molecular machinery which facilitates fusion. Its ectodomain contains several distinguishing functional domains, fusion peptide (FP), Nterminal heptad repeat (NHR), C-terminal heptad repeat (CHR) and membrane proximal extracellular region (MPER). During the fusion process, FP inserts into the host cell membrane, and an extended gp41 prehairpin conformation bridges the viral and cell membranes through MPER and FP respectively. Subsequent conformational change of the unstable prehairpin results in a coiled-coil 6-helix bundle (6HB) structure formed between NHR and CHR. The energetics of 6HB formation drives membrane apposition and fusion. Drugs targeting gp41 functional domains to prevent 6HB formation inhibit HIV-1 infection. T20 (enfuvirtide, Fuzeon) was approved by the US FDA in 2003 as the first fusion inhibitor. It is a 36-residue peptide from the gp41 CHR, and it inhibits 6HB formation by targeting NHR and lipids. Development of new fusion inhibitors, especially small molecule drugs, is encouraged to overcome the shortcomings of T20 as a peptide drug. Hydrophobic characteristics and membrane association are critical for gp41 function and mechanism of action. Research in gp41-membrane interactions, using peptides corresponding to specific functional domains, or constructs including several interactive domains, are reviewed here to get a better understanding of gp41 mediated virus-cell fusion that can inform or guide the design of new HIV-1 fusion inhibitors.

  4. The Role of Strong Coupling in Z-Pinch-Driven Approaches to High Yield Inertial Confinement Fusion

    International Nuclear Information System (INIS)

    MEHLHORN, THOMAS A.; DESJARLAIS, MICHAEL P.; HAILL, THOMAS A.; LASH, JOEL S.; ROSENTHAL, STEPHEN E.; SLUTZ, STEPHEN A.; STOLTZ, PETER H.; VESEY, ROGER A.; OLIVER, B.

    1999-01-01

    Peak x-ray powers as high as 280 ± 40 TW have been generated from the implosion of tungsten wire arrays on the Z Accelerator at Sandia National Laboratories. The high x-ray powers radiated by these z-pinches provide an attractive new driver option for high yield inertial confinement fusion (ICF). The high x-ray powers appear to be a result of using a large number of wires in the array which decreases the perturbation seed to the magnetic Rayleigh-Taylor (MRT) instability and diminishes other 3-D effects. Simulations to confirm this hypothesis require a 3-D MHD code capability, and associated databases, to follow the evolution of the wires from cold solid through melt, vaporization, ionization, and finally to dense imploded plasma. Strong coupling plays a role in this process, the importance of which depends on the wire material and the current time history of the pulsed power driver. Strong coupling regimes are involved in the plasmas in the convolute and transmission line of the powerflow system. Strong coupling can also play a role in the physics of the z-pinch-driven high yield ICF target. Finally, strong coupling can occur in certain z-pinch-driven application experiments

  5. Fusion at counterstreaming ion beams - ion optic fusion (IOF)

    International Nuclear Information System (INIS)

    Gryzinski, M.

    1981-01-01

    The results of investigation are briefly reviewed in the field of ion optic fusion performed at the Institute of Nuclear Research in Swierk. The ion optic fusion concept is based on the possibility of obtaining fusion energy at highly ordered motion of ions in counterstreaming ion beams. For this purpose TW ion beams must be produced and focused. To produce dense and charge-neutralized ion beams the selective conductivity and ballistic focusing ideas were formulated and used in a series of RPI devices with low-pressure cylindrical discharge between grid-type electrodes. 100 kA, 30 keV deuteron beams were successfully produced and focused into the volume of 1 cm 3 , yielding 10 9 neutrons per 200 ns shot on a heavy ice target. Cylindrically convergent ion beams with magnetic anti-defocusing were proposed in order to reach a positive energy gain at reasonable energy level. (J.U.)

  6. 46 CFR 97.15-15 - Examination of boilers and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Examination of boilers and machinery. 97.15-15 Section... VESSELS OPERATIONS Tests, Drills, and Inspections § 97.15-15 Examination of boilers and machinery. It shall be the duty of the chief engineer when assuming charge of the boilers and machinery of a vessel to...

  7. 46 CFR 32.35-1 - Boilers and machinery-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Boilers and machinery-TB/ALL. 32.35-1 Section 32.35-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Main and Auxiliary Machinery § 32.35-1 Boilers and machinery—TB/ALL. Boilers, main and auxiliary...

  8. 46 CFR 78.17-30 - Examination of boilers and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Examination of boilers and machinery. 78.17-30 Section... OPERATIONS Tests, Drills, and Inspections § 78.17-30 Examination of boilers and machinery. It shall be the duty of the chief engineer when assuming charge of the boilers and machinery of a vessel to examine...

  9. Machinery condition monitoring principles and practices

    CERN Document Server

    Mohanty, Amiya Ranjan

    2015-01-01

    Find the Fault in the MachinesDrawing on the author's more than two decades of experience with machinery condition monitoring and consulting for industries in India and abroad, Machinery Condition Monitoring: Principles and Practices introduces the practicing engineer to the techniques used to effectively detect and diagnose faults in machines. Providing the working principle behind the instruments, the important elements of machines as well as the technique to understand their conditions, this text presents every available method of machine fault detection occurring in machines in general, an

  10. The fusion rate in the transmission resonance model

    International Nuclear Information System (INIS)

    Jaendel, M.

    1992-01-01

    Resonant transmission of deuterons through a chain of target deuterons in a metal matrix has been suggested as an explanation for the cold fusion phenomena. In this paper the fusion rate in such transmission resonance models is estimated, and the basic physical constraints are discussed. The dominating contribution to the fusion yield is found to come from metastable states. The fusion rate is well described by the Wentzel-Kramer-Brillouin approximation and appears to be much too small to explain the experimental anomalies

  11. 46 CFR 196.15-15 - Examination of boilers and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Examination of boilers and machinery. 196.15-15 Section... VESSELS OPERATIONS Test, Drills, and Inspections § 196.15-15 Examination of boilers and machinery. (a) It shall be the duty of the chief engineer when he assumes charge of the boilers and machinery of a vessel...

  12. The technology benefits of inertial confinement fusion research

    International Nuclear Information System (INIS)

    Powell, H.T.

    1999-01-01

    The development and demonstration of inertial fusion is incredibly challenging because it requires simultaneously controlling and precisely measuring parameters at extreme values in energy, space, and time. The challenges range from building megajoule (10 6 J) drivers that perform with percent-level precision to fabricating targets with submicron specifications to measuring target performance at micron scale (10 -6 m) with picosecond (10 -12 s) time resolution. Over the past 30 years in attempting to meet this challenge, the inertial fusion community around the world has invented new technologies in lasers, particle beams, pulse power drivers, diagnostics, target fabrication, and other areas. These technologies have found applications in diverse fields of industry and science. Moreover, simply assembling the teams with the background, experience, and personal drive to meet the challenging requirements of inertial fusion has led to spin-offs in unexpected directions, for example, in laser isotope separation, extreme ultraviolet lithography for microelectronics, compact and inexpensive radars, advanced laser materials processing, and medical technology. The experience of inertial fusion research and development of spinning off technologies has not been unique to any one laboratory or country but has been similar in main research centers in the US, Europe, and Japan. Strengthening and broadening the inertial fusion effort to focus on creating a new source of electrical power (inertial fusion energy [IFE]) that is economically competitive and environmentally benign will yield rich rewards in technology spin-offs. The additional challenges presented by IFE are to make drivers affordable, efficient, and long-lived while operating at a repetition rate of a few Hertz; to make fusion targets that perform consistently at high-fusion yield; and to create target chambers that can repetitively handle greater than 100-MJ yields while producing minimal radioactive by

  13. Vibration of hydraulic machinery

    CERN Document Server

    Wu, Yulin; Liu, Shuhong; Dou, Hua-Shu; Qian, Zhongdong

    2013-01-01

    Vibration of Hydraulic Machinery deals with the vibration problem which has significant influence on the safety and reliable operation of hydraulic machinery. It provides new achievements and the latest developments in these areas, even in the basic areas of this subject. The present book covers the fundamentals of mechanical vibration and rotordynamics as well as their main numerical models and analysis methods for the vibration prediction. The mechanical and hydraulic excitations to the vibration are analyzed, and the pressure fluctuations induced by the unsteady turbulent flow is predicted in order to obtain the unsteady loads. This book also discusses the loads, constraint conditions and the elastic and damping characters of the mechanical system, the structure dynamic analysis, the rotor dynamic analysis and the system instability of hydraulic machines, including the illustration of monitoring system for the instability and the vibration in hydraulic units. All the problems are necessary for vibration pr...

  14. The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery.

    Science.gov (United States)

    Poëa-Guyon, Sandrine; Ammar, Mohamed Raafet; Erard, Marie; Amar, Muriel; Moreau, Alexandre W; Fossier, Philippe; Gleize, Vincent; Vitale, Nicolas; Morel, Nicolas

    2013-10-28

    Several studies have suggested that the V0 domain of the vacuolar-type H(+)-adenosine triphosphatase (V-ATPase) is directly implicated in secretory vesicle exocytosis through a role in membrane fusion. We report in this paper that there was a rapid decrease in neurotransmitter release after acute photoinactivation of the V0 a1-I subunit in neuronal pairs. Likewise, inactivation of the V0 a1-I subunit in chromaffin cells resulted in a decreased frequency and prolonged kinetics of amperometric spikes induced by depolarization, with shortening of the fusion pore open time. Dissipation of the granular pH gradient was associated with an inhibition of exocytosis and correlated with the V1-V0 association status in secretory granules. We thus conclude that V0 serves as a sensor of intragranular pH that controls exocytosis and synaptic transmission via the reversible dissociation of V1 at acidic pH. Hence, the V-ATPase membrane domain would allow the exocytotic machinery to discriminate fully loaded and acidified vesicles from vesicles undergoing neurotransmitter reloading.

  15. AGGREGATION AND FUSION OF PLANT-PROTOPLASTS AFTER SURFACE-LABELING WITH BIOTIN AND AVIDIN

    NARCIS (Netherlands)

    VANKESTEREN, WJP; MOLEMA, E; TEMPELAAR, MJ

    1993-01-01

    In mass electrofusion systems with aggregation of protoplasts by alignment, the yield and composition of fusion products can be predicted by a simple model. Through computer simulation, upper limits were found for the yield of binary and multi fusions. To overcome constraints on binary products,

  16. 46 CFR 78.33-5 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Accidents to machinery. 78.33-5 Section 78.33-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Reports of Accidents, Repairs, and Unsafe Equipment § 78.33-5 Accidents to machinery. (a) In the event of an accident...

  17. Two-pulse driving of D+D nuclear fusion within a single Coulomb exploding nanodroplet

    International Nuclear Information System (INIS)

    Last, Isidore; Jortner, Joshua; Peano, Fabio; Silva, Luis O.

    2010-01-01

    This paper presents a computational study of D+D fusion driven by Coulomb explosion (CE) within a single, homonuclear deuterium nanodroplet, subjected to double-pulse ultraintense laser irradiation. This irradiation scheme results in the attainment (by the first weaker pulse) of a transient inhomogeneous density profile, which serves as a target for the driving (by the second superintense pulse) of nonuniform CE that triggers overrun effects and induces intrananodroplet (INTRA) D+D fusion. Scaled electron and ion dynamics simulations were utilized to explore the INTRA D+D fusion yields for double-pulse, near-infrared laser irradiation of deuterium nanodroplets. The dependence of the INTRA yield on the nanodroplet size and on the parameters of the two laser pulses was determined, establishing the conditions for the prevalence of efficient INTRA fusion. The INTRA fusion yields are amenable to experimental observation within an assembly of nanodroplets. The INTRA D+D fusion can be distinguished from the concurrent internanodroplet D+D fusion reaction occurring in the macroscopic plasma filament and outside it in terms of the different energies of the neutrons produced in these two channels.

  18. Open innovation and supply chain management in food machinery ...

    African Journals Online (AJOL)

    Open innovation and supply chain management in food machinery supply chain: a ... This paradigm describes a new approach to internal R&D management, which ... a picture of the adoption of open innovation in the food machinery industry.

  19. 46 CFR 169.629 - Compartments containing gasoline machinery or fuel tanks.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Compartments containing gasoline machinery or fuel tanks. 169.629 Section 169.629 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL... gasoline machinery or fuel tanks. Spaces containing gasoline machinery or fuel tanks must have natural...

  20. 46 CFR 116.620 - Ventilation of machinery and fuel tank spaces.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Ventilation of machinery and fuel tank spaces. 116.620... AND ARRANGEMENT Ventilation § 116.620 Ventilation of machinery and fuel tank spaces. In addition to the requirements of this subpart, ventilation systems for spaces containing machinery or fuel tanks...

  1. Optimization of a high-yield, low-areal-density fusion product source at the National Ignition Facility with applications in nucleosynthesis experiments

    Science.gov (United States)

    Gatu Johnson, M.; Casey, D. T.; Hohenberger, M.; Zylstra, A. B.; Bacher, A.; Brune, C. R.; Bionta, R. M.; Craxton, R. S.; Ellison, C. L.; Farrell, M.; Frenje, J. A.; Garbett, W.; Garcia, E. M.; Grim, G. P.; Hartouni, E.; Hatarik, R.; Herrmann, H. W.; Hohensee, M.; Holunga, D. M.; Hoppe, M.; Jackson, M.; Kabadi, N.; Khan, S. F.; Kilkenny, J. D.; Kohut, T. R.; Lahmann, B.; Le, H. P.; Li, C. K.; Masse, L.; McKenty, P. W.; McNabb, D. P.; Nikroo, A.; Parham, T. G.; Parker, C. E.; Petrasso, R. D.; Pino, J.; Remington, B.; Rice, N. G.; Rinderknecht, H. G.; Rosenberg, M. J.; Sanchez, J.; Sayre, D. B.; Schoff, M. E.; Shuldberg, C. M.; Séguin, F. H.; Sio, H.; Walters, Z. B.; Whitley, H. D.

    2018-05-01

    Polar-direct-drive exploding pushers are used as a high-yield, low-areal-density fusion product source at the National Ignition Facility with applications including diagnostic calibration, nuclear security, backlighting, electron-ion equilibration, and nucleosynthesis-relevant experiments. In this paper, two different paths to improving the performance of this platform are explored: (i) optimizing the laser drive, and (ii) optimizing the target. While the present study is specifically geared towards nucleosynthesis experiments, the results are generally applicable. Example data from T2/3He-gas-filled implosions with trace deuterium are used to show that yield and ion temperature (Tion) from 1.6 mm-outer-diameter thin-glass-shell capsule implosions are improved at a set laser energy by switching from a ramped to a square laser pulse shape, and that increased laser energy further improves yield and Tion, although by factors lower than predicted by 1 D simulations. Using data from D2/3He-gas-filled implosions, yield at a set Tion is experimentally verified to increase with capsule size. Uniform D3He-proton spectra from 3 mm-outer-diameter CH shell implosions demonstrate the utility of this platform for studying charged-particle-producing reactions relevant to stellar nucleosynthesis.

  2. Yield degradation in inertial-confinement-fusion implosions due to shock-driven kinetic fuel-species stratification and viscous heating

    Science.gov (United States)

    Taitano, W. T.; Simakov, A. N.; Chacón, L.; Keenan, B.

    2018-05-01

    Anomalous thermonuclear yield degradation (i.e., that not describable by single-fluid radiation hydrodynamics) in Inertial Confinement Fusion (ICF) implosions is ubiquitously observed in both Omega and National Ignition experiments. Multiple experimental and theoretical studies have been carried out to investigate the origin of such a degradation. Relative concentration changes of fuel-ion species, as well as kinetically enhanced viscous heating, have been among possible explanations proposed for certain classes of ICF experiments. In this study, we investigate the role of such kinetic plasma effects in detail. To this end, we use the iFP code to perform multi-species ion Vlasov-Fokker-Planck simulations of ICF capsule implosions with the fuel comprising various hydrodynamically equivalent mixtures of deuterium (D) and helium-3 (3He), as in the original Rygg experiments [J. R. Rygg et al., Phys. Plasmas 13, 052702 (2006)]. We employ the same computational setup as in O. Larroche [Phys. Plasmas 19, 122706 (2012)], which was the first to simulate the experiments kinetically. However, unlike the Larroche study, and in partial agreement with experimental data, we find a systematic yield degradation in multi-species simulations versus averaged-ion simulations when the D-fuel fraction is decreased. This yield degradation originates in the fuel-ion species stratification induced by plasma shocks, which imprints the imploding system and results in the relocation of the D ions from the core of the capsule to its periphery, thereby reducing the yield relative to a non-separable averaged-ion case. By comparing yields from the averaged-ion kinetic simulations and from the hydrodynamic scaling, we also observe yield variations associated with ion kinetic effects other than fuel-ion stratification, such as ion viscous heating, which is typically neglected in hydrodynamic implosions' simulations. Since our kinetic simulations are driven by hydrodynamic boundary conditions at the

  3. 46 CFR 91.15-1 - Standards in inspection of hulls, boilers, and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Standards in inspection of hulls, boilers, and machinery... hulls, boilers, and machinery. In the inspection of hulls, boilers, and machinery of vessels, the..., respecting material and inspection of hulls, boilers, and machinery, and the certificate of classification...

  4. 46 CFR 189.15-1 - Standards in inspection of hulls, boilers, and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Standards in inspection of hulls, boilers, and machinery... inspection of hulls, boilers, and machinery. In the inspection of hulls, boilers, and machinery of vessels... chapter, respecting material and construction of hulls, boilers, and machinery, and certificate of...

  5. 46 CFR 71.15-1 - Standards in inspection of hulls, boilers, and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Standards in inspection of hulls, boilers, and machinery..., boilers, and machinery. In the inspection of hulls, boilers, and machinery of vessels, the standards... and inspection of hulls, boilers, and machinery, and the certificate of classification referring...

  6. Investigation of condensed matter fusion

    International Nuclear Information System (INIS)

    Jones, S.E.; Berrondo, M.; Czirr, J.B.; Decker, D.L.; Harrison, K.; Jensen, G.L.; Palmer, E.P.; Rees, L.B.; Taylor, S.; Vanfleet, H.B.; Wang, J.C.; Bennion, D.N.; Harb, J.N.; Pitt, W.G.; Thorne, J.M.; Anderson, A.N.; McMurtry, G.; Murphy, N.; Goff, F.E.

    1990-12-01

    Work on muon-catalyzed fusion led to research on a possible new type of fusion occurring in hydrogen isotopes embedded in metal lattices. While the nuclear-product yields observed to date are so small as to require careful further checking, rates observed over short times appear sufficiently large to suggest that significant neutrons and triton yields could be realized -- if the process could be understood and controlled. During 1990, we have developed two charged-particle detection systems and three new neutron detectors. A segmented, high-efficiency neutron counter was taken into 600 m underground in a mine in Colorado for studies out of the cosmic-ray background. Significant neutron emissions were observed in this environment in both deuterium-gas-loaded metals and in electrolytic cells, confirming our earlier observations

  7. Crystal structure of the conserved herpesvirus fusion regulator complex gH—gL

    Energy Technology Data Exchange (ETDEWEB)

    Chowdary, Tirumala K.; Cairns, Tina M.; Atanasiu, Doina; Cohen, Gary H.; Eisenberg, Roselyn J.; Heldwein, Ekaterina E. [UPENN; (Tufts-MED)

    2015-02-09

    Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gB and the heterodimer gH–gL, plus other nonconserved components. gB is a class III viral fusogen, but unlike other members of its class, it does not function alone. We determined the crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2. gH–gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen. Instead, we propose that gH–gL activates gB for fusion, possibly through direct binding. Formation of a gB–gH–gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB–gH–gL interface a promising antiviral target.

  8. 49 CFR 1242.47 - Machinery (account XX-27-40).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Machinery (account XX-27-40). 1242.47 Section 1242...-Equipment § 1242.47 Machinery (account XX-27-40). Separate common expenses on the basis of the freight/passenger separation of administration (account XX-27-01). ...

  9. 46 CFR 169.315 - Ventilation (other than machinery spaces).

    Science.gov (United States)

    2010-10-01

    ... section is satisfied, a vessel having only a natural ventilation system must satisfy the following: V/A≥1... 46 Shipping 7 2010-10-01 2010-10-01 false Ventilation (other than machinery spaces). 169.315... SCHOOL VESSELS Construction and Arrangement Hull Structure § 169.315 Ventilation (other than machinery...

  10. Statistical rice yield modeling using blended MODIS-Landsat based crop phenology metrics in Taiwan

    Science.gov (United States)

    Chen, C. R.; Chen, C. F.; Nguyen, S. T.; Lau, K. V.

    2015-12-01

    Taiwan is a populated island with a majority of residents settled in the western plains where soils are suitable for rice cultivation. Rice is not only the most important commodity, but also plays a critical role for agricultural and food marketing. Information of rice production is thus important for policymakers to devise timely plans for ensuring sustainably socioeconomic development. Because rice fields in Taiwan are generally small and yet crop monitoring requires information of crop phenology associating with the spatiotemporal resolution of satellite data, this study used Landsat-MODIS fusion data for rice yield modeling in Taiwan. We processed the data for the first crop (Feb-Mar to Jun-Jul) and the second (Aug-Sep to Nov-Dec) in 2014 through five main steps: (1) data pre-processing to account for geometric and radiometric errors of Landsat data, (2) Landsat-MODIS data fusion using using the spatial-temporal adaptive reflectance fusion model, (3) construction of the smooth time-series enhanced vegetation index 2 (EVI2), (4) rice yield modeling using EVI2-based crop phenology metrics, and (5) error verification. The fusion results by a comparison bewteen EVI2 derived from the fusion image and that from the reference Landsat image indicated close agreement between the two datasets (R2 > 0.8). We analysed smooth EVI2 curves to extract phenology metrics or phenological variables for establishment of rice yield models. The results indicated that the established yield models significantly explained more than 70% variability in the data (p-value 0.8), in both cases. The root mean square error (RMSE) and mean absolute error (MAE) used to measure the model accuracy revealed the consistency between the estimated yields and the government's yield statistics. This study demonstrates advantages of using EVI2-based phenology metrics (derived from Landsat-MODIS fusion data) for rice yield estimation in Taiwan prior to the harvest period.

  11. Fusion Policy Advisory Committee (FPAC)

    International Nuclear Information System (INIS)

    1990-09-01

    This document is the final report of the Fusion Policy Advisory Committee. The report conveys the Committee's views on the matters specified by the Secretary in his charge and subsequent letters to the Committee, and also satisfies the provisions of Section 7 of the Magnetic Fusion Energy Engineering Act of 1980, Public Law 96-386, which require a triennial review of the conduct of the national Magnetic Fusion Energy program. Three sub-Committee's were established to address the large number of topics associated with fusion research and development. One considered magnetic fusion energy, a second considered inertial fusion energy, and the third considered issues common to both. For many reasons, the promise of nuclear fusion as a safe, environmentally benign, and affordable source of energy is bright. At the present state of knowledge, however, it is uncertain that this promise will become reality. Only a vigorous, well planned and well executed program of research and development will yield the needed information. The Committee recommends that the US commit to a plan that will resolve this critically important issue. It also outlines the first steps in a development process that will lead to a fusion Demonstration Power Plant by 2025. The recommended program is aggressive, but we believe the goal is reasonable and attainable. International collaboration at a significant level is an important element in the plan

  12. Crystal Structure of the Conserved Herpes Virus Fusion Regulator Complex gH–gL

    Energy Technology Data Exchange (ETDEWEB)

    Chowdary, T.; Cairns, T; Atanasiu, D; Cohen, G; Eisenberg, R; Heldwein, E

    2010-01-01

    Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gB and the heterodimer gH-gL, plus other nonconserved components. gB is a class III viral fusogen, but unlike other members of its class, it does not function alone. We determined the crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2. gH-gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen. Instead, we propose that gH-gL activates gB for fusion, possibly through direct binding. Formation of a gB-gH-gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB-gH-gL interface a promising antiviral target.

  13. Crystal structure of the conserved herpes virus fusion regulator complex gH-gL

    Energy Technology Data Exchange (ETDEWEB)

    Chowdary, Tirumala K; Cairns, Tina M; Atanasiu, Doina; Cohen, Gary H; Eisenberg, Roselyn J; Heldwein, Ekaterina E [UPENN; (Tufts-MED)

    2010-09-13

    Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gB and the heterodimer gH-gL, plus other nonconserved components. gB is a class III viral fusogen, but unlike other members of its class, it does not function alone. We determined the crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2. gH-gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen. Instead, we propose that gH-gL activates gB for fusion, possibly through direct binding. Formation of a gB-gH-gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB-gH-gL interface a promising antiviral target.

  14. Numerical Experiments Providing New Insights into Plasma Focus Fusion Devices

    Directory of Open Access Journals (Sweden)

    Sing Lee

    2010-04-01

    Full Text Available Recent extensive and systematic numerical experiments have uncovered new insights into plasma focus fusion devices including the following: (1 a plasma current limitation effect, as device static inductance is reduced towards very small values; (2 scaling laws of neutron yield and soft x-ray yield as functions of storage energies and currents; (3 a global scaling law for neutron yield as a function of storage energy combining experimental and numerical data showing that scaling deterioration has probably been interpreted as neutron ‘saturation’; and (4 a fundamental cause of neutron ‘saturation’. The ground-breaking insights thus gained may completely change the directions of plasma focus fusion research.

  15. 40 CFR 180.521 - Fumigants for grain-mill machinery; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Fumigants for grain-mill machinery... Tolerances § 180.521 Fumigants for grain-mill machinery; tolerances for residues. (a) General. Fumigants may be safely used in or on grain-mill machinery in accordance with the following prescribed conditions...

  16. Multifocus Image Fusion in Q-Shift DTCWT Domain Using Various Fusion Rules

    Directory of Open Access Journals (Sweden)

    Yingzhong Tian

    2016-01-01

    Full Text Available Multifocus image fusion is a process that integrates partially focused image sequence into a fused image which is focused everywhere, with multiple methods proposed in the past decades. The Dual Tree Complex Wavelet Transform (DTCWT is one of the most precise ones eliminating two main defects caused by the Discrete Wavelet Transform (DWT. Q-shift DTCWT was proposed afterwards to simplify the construction of filters in DTCWT, producing better fusion effects. A different image fusion strategy based on Q-shift DTCWT is presented in this work. According to the strategy, firstly, each image is decomposed into low and high frequency coefficients, which are, respectively, fused by using different rules, and then various fusion rules are innovatively combined in Q-shift DTCWT, such as the Neighborhood Variant Maximum Selectivity (NVMS and the Sum Modified Laplacian (SML. Finally, the fused coefficients could be well extracted from the source images and reconstructed to produce one fully focused image. This strategy is verified visually and quantitatively with several existing fusion methods based on a plenty of experiments and yields good results both on standard images and on microscopic images. Hence, we can draw the conclusion that the rule of NVMS is better than others after Q-shift DTCWT.

  17. Genome-scale modeling of the protein secretory machinery in yeast

    DEFF Research Database (Denmark)

    Feizi, Amir; Österlund, Tobias; Petranovic, Dina

    2013-01-01

    The protein secretory machinery in Eukarya is involved in post-translational modification (PTMs) and sorting of the secretory and many transmembrane proteins. While the secretory machinery has been well-studied using classic reductionist approaches, a holistic view of its complex nature is lacking....... Here, we present the first genome-scale model for the yeast secretory machinery which captures the knowledge generated through more than 50 years of research. The model is based on the concept of a Protein Specific Information Matrix (PSIM: characterized by seven PTMs features). An algorithm...

  18. A compact proton spectrometer for measurement of the absolute DD proton spectrum from which yield and ρR are determined in thin-shell inertial-confinement-fusion implosions

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, M. J., E-mail: mrosenbe@mit.edu; Zylstra, A. B.; Frenje, J. A.; Rinderknecht, H. G.; Gatu Johnson, M.; Waugh, C. J.; Séguin, F. H.; Sio, H.; Sinenian, N.; Li, C. K.; Petrasso, R. D. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Glebov, V. Yu.; Hohenberger, M.; Stoeckl, C.; Sangster, T. C. [Laboratory for Laser Energetics, University of Rochester, Rochester, New York 14623 (United States); Yeamans, C. B.; LePape, S.; Mackinnon, A. J.; Bionta, R. M.; Talison, B. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); and others

    2014-10-01

    A compact, step range filter proton spectrometer has been developed for the measurement of the absolute DD proton spectrum, from which yield and areal density (ρR) are inferred for deuterium-filled thin-shell inertial confinement fusion implosions. This spectrometer, which is based on tantalum step-range filters, is sensitive to protons in the energy range 1-9 MeV and can be used to measure proton spectra at mean energies of ~1-3 MeV. It has been developed and implemented using a linear accelerator and applied to experiments at the OMEGA laser facility and the National Ignition Facility (NIF). Modeling of the proton slowing in the filters is necessary to construct the spectrum, and the yield and energy uncertainties are ±<10% in yield and ±120 keV, respectively. This spectrometer can be used for in situ calibration of DD-neutron yield diagnostics at the NIF.

  19. Intense ion beams for inertial confinement fusion

    International Nuclear Information System (INIS)

    Mehlhorn, T.A.

    1997-01-01

    Intense beams of light of heavy ions are being studied as inertial confinement fusion (ICF) drivers for high yield and energy. Heavy and light ions have common interests in beam transport, targets, and alternative accelerators. Self-pinched transport is being jointly studied. This article reviews the development of intense ion beams for ICF. Light-ion drivers are highlighted because they are compact, modular, efficient and low cost. Issues facing light ions are: (1) decreasing beam divergence; (2) increasing beam brightness; and (3) demonstrating self-pinched transport. Applied-B ion diodes are favored because of efficiency, beam brightness, perceived scalability, achievable focal intensity, and multistage capability. A light-ion concept addressing these issues uses: (1) an injector divergence of ≤ 24 mrad at 9 MeV; (2) two-stage acceleration to reduce divergence to ≤ 12 mrad at 35 MeV; and (3) self-pinched transport accepting divergences up to 12 mrad. Substantial progress in ion-driven target physics and repetitive ion diode technology is also presented. Z-pinch drivers are being pursued as the shortest pulsed power path to target physics experiments and high-yield fusion. However, light ions remain the pulsed power ICF driver of choice for high-yield fusion energy applications that require driver standoff and repetitive operation. 100 refs

  20. Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus

    Energy Technology Data Exchange (ETDEWEB)

    Hashem, Anwar M. [Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON (Canada); Department of Microbiology, Faculty of Medicine, King Abdulaziz University, Jeddah (Saudi Arabia); Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON (Canada); Van Domselaar, Gary [National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB (Canada); Li, Changgui; Wang, Junzhi [National Institute for the Control of Pharmaceutical and Biological Products, Beijing (China); She, Yi-Min; Cyr, Terry D. [Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON (Canada); Sui, Jianhua [Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, 44 Binney Street, Boston, MA 02115 (United States); He, Runtao [National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB (Canada); Marasco, Wayne A. [Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, 44 Binney Street, Boston, MA 02115 (United States); Li, Xuguang, E-mail: Sean.Li@hc-sc.gc.ca [Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON (Canada); Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON (Canada)

    2010-12-10

    Research highlights: {yields} The fusion peptide is the only universally conserved epitope in all influenza viral hemagglutinins. {yields} Anti-fusion peptide antibodies are universal antibodies that cross-react with all influenza HA subtypes. {yields} The universal antibodies cross-neutralize different influenza A subtypes. {yields} The universal antibodies inhibit the fusion process between the viruses and the target cells. -- Abstract: The fusion peptide of influenza viral hemagglutinin plays a critical role in virus entry by facilitating membrane fusion between the virus and target cells. As the fusion peptide is the only universally conserved epitope in all influenza A and B viruses, it could be an attractive target for vaccine-induced immune responses. We previously reported that antibodies targeting the first 14 amino acids of the N-terminus of the fusion peptide could bind to virtually all influenza virus strains and quantify hemagglutinins in vaccines produced in embryonated eggs. Here we demonstrate that these universal antibodies bind to the viral hemagglutinins in native conformation presented in infected mammalian cell cultures and neutralize multiple subtypes of virus by inhibiting the pH-dependant fusion of viral and cellular membranes. These results suggest that this unique, highly-conserved linear sequence in viral hemagglutinin is exposed sufficiently to be attacked by the antibodies during the course of infection and merits further investigation because of potential importance in the protection against diverse strains of influenza viruses.

  1. Regulation of Exocytotic Fusion Pores by SNARE Protein Transmembrane Domains

    Directory of Open Access Journals (Sweden)

    Zhenyong Wu

    2017-10-01

    Full Text Available Calcium-triggered exocytotic release of neurotransmitters and hormones from neurons and neuroendocrine cells underlies neuronal communication, motor activity and endocrine functions. The core of the neuronal exocytotic machinery is composed of soluble N-ethyl maleimide sensitive factor attachment protein receptors (SNAREs. Formation of complexes between vesicle-attached v- and plasma-membrane anchored t-SNAREs in a highly regulated fashion brings the membranes into close apposition. Small, soluble proteins called Complexins (Cpx and calcium-sensing Synaptotagmins cooperate to block fusion at low resting calcium concentrations, but trigger release upon calcium increase. A growing body of evidence suggests that the transmembrane domains (TMDs of SNARE proteins play important roles in regulating the processes of fusion and release, but the mechanisms involved are only starting to be uncovered. Here we review recent evidence that SNARE TMDs exert influence by regulating the dynamics of the fusion pore, the initial aqueous connection between the vesicular lumen and the extracellular space. Even after the fusion pore is established, hormone release by neuroendocrine cells is tightly controlled, and the same may be true of neurotransmitter release by neurons. The dynamics of the fusion pore can regulate the kinetics of cargo release and the net amount released, and can determine the mode of vesicle recycling. Manipulations of SNARE TMDs were found to affect fusion pore properties profoundly, both during exocytosis and in biochemical reconstitutions. To explain these effects, TMD flexibility, and interactions among TMDs or between TMDs and lipids have been invoked. Exocytosis has provided the best setting in which to unravel the underlying mechanisms, being unique among membrane fusion reactions in that single fusion pores can be probed using high-resolution methods. An important role will likely be played by methods that can probe single fusion pores

  2. International fusion research

    International Nuclear Information System (INIS)

    Pease, R.S.

    1983-01-01

    Nuclear energy of the light elements deuterium and lithium can be released if the 100 MK degree temperature required for deuterium-tritium thermonuclear fusion reactions can be achieved together with sufficient thermal insulation for a net energy yield. Progress of world-wide research shows good prospect for these physical conditions being achieved by the use of magnetic field confinement and of rapidly developing heating methods. Tokamak systems, alternative magnetic systems and inertial confinement progress are described. International co-operation features a number of bilateral agreements between countries: the Euratom collaboration which includes the Joint European Torus, a joint undertaking of eleven Western European nations of Euratom, established to build and operate a major confinement experiment; the development of co-operative projects within the OECD/IEA framework; the INTOR workshop, a world-wide study under IAEA auspices of the next major step in fusion research which might be built co-operatively; and assessments of the potential of nuclear fusion by the IAEA and the International Fusion Research Council. The INTOR (International Tokamak Reactor) studies have outlined a major plant of the tokamak type to study the engineering and technology of fusion reactor systems, which might be constructed on a world-wide basis to tackle and share the investment risks of the developments which lie ahead. This paper summarizes the recent progress of research on controlled nuclear fusion, featuring those areas where international co-operation has played an important part, and describes the various arrangements by which this international co-operation is facilitated. (author)

  3. Machinery failure analysis and troubleshooting practical machinery management for process plants

    CERN Document Server

    Bloch, Heinz P

    2012-01-01

    Solve the machinery failure problems costing you time and money with this classic, comprehensive guide to analysis and troubleshooting  Provides detailed, complete and accurate information on anticipating risk of component failure and avoiding equipment downtime Includes numerous photographs of failed parts to ensure you are familiar with the visual evidence you need to recognize Covers proven approaches to failure definition and offers failure identification and analysis methods that can be applied to virtually all problem situations Demonstr

  4. A compact proton spectrometer for measurement of the absolute DD proton spectrum from which yield and ρR are determined in thin-shell inertial-confinement-fusion implosions.

    Science.gov (United States)

    Rosenberg, M J; Zylstra, A B; Frenje, J A; Rinderknecht, H G; Johnson, M Gatu; Waugh, C J; Séguin, F H; Sio, H; Sinenian, N; Li, C K; Petrasso, R D; Glebov, V Yu; Hohenberger, M; Stoeckl, C; Sangster, T C; Yeamans, C B; LePape, S; Mackinnon, A J; Bionta, R M; Talison, B; Casey, D T; Landen, O L; Moran, M J; Zacharias, R A; Kilkenny, J D; Nikroo, A

    2014-10-01

    A compact, step range filter proton spectrometer has been developed for the measurement of the absolute DD proton spectrum, from which yield and areal density (ρR) are inferred for deuterium-filled thin-shell inertial confinement fusion implosions. This spectrometer, which is based on tantalum step-range filters, is sensitive to protons in the energy range 1-9 MeV and can be used to measure proton spectra at mean energies of ∼1-3 MeV. It has been developed and implemented using a linear accelerator and applied to experiments at the OMEGA laser facility and the National Ignition Facility (NIF). Modeling of the proton slowing in the filters is necessary to construct the spectrum, and the yield and energy uncertainties are ±DD-neutron yield diagnostics at the NIF.

  5. Radiation technologies in metallurgy and machinery

    International Nuclear Information System (INIS)

    Meshkov, I.N.

    1990-01-01

    Applications of electron beam accelerators for technologies in metallurgy and machinery are discussed. Processes described are provided with special industrial accelerators, developed in the Institute of Nuclear Physics, Novosibirsk. (author)

  6. FOREWORD: 26th IAHR Symposium on Hydraulic Machinery and Systems

    Science.gov (United States)

    Wu, Yulin; Wang, Zhengwei; Liu, Shuhong; Yuan, Shouqi; Luo, Xingqi; Wang, Fujun

    2012-11-01

    The 26th IAHR Symposium on Hydraulic Machinery and Systems, will be held in Beijing, China, 19-23 August 2012. It is jointly organized by Tsinghua University, State Key Laboratory of Hydro Science and Hydraulic Engineering, China, Jiangsu University, Xi'an University of Technology, China Agricultural University, National Engineering Research Center of Hydropower Equipment and Dongfang Electric Machinery Co., Ltd. It is the second time that China hosts such a symposium. By the end of 2011, the China electrical power system had a total of 1 050 GW installed power, out of which 220 GW was in hydropower plants. The energy produced in hydropower facilities was 662.6 TWh from a total of 4,720 TWh electrical energy production in 2011. Moreover, in 2020, new hydropower capacities are going to be developed, with a total of 180 GW installed power and an estimated 708 TWh/year energy production. And in 2011, the installed power of pumped storage stations was about 25GW. In 2020, the data will be 70GW. At the same time, the number of pumps used in China is increasing rapidly. China produces about 29,000,000 pumps with more than 220 series per year. By the end of 2011, the Chinese pumping system has a total of 950 GW installed power. The energy consumed in pumping facilities was 530 TWh in 2011. The pump energy consumption accounted for about 12% of the national electrical energy production. Therefore, there is a large market in the field of hydraulic machinery including water turbines, pump turbines and a variety of pumps in China. There are also many research projects in this field. For example, we have conducted National Key Research Projects on 1000 MW hydraulic turbine, and on the pump turbines with high head, as well as on the large capacity pumps for water supply. Tsinghua University of Beijing is proud to host the 26th IAHR Symposium on Hydraulic Machinery and Systems. Tsinghua University was established in 1911, after the founding of the People's Republic of China. It

  7. Numerical studies of deuterium-tritium ignition in impact-fusion targets

    International Nuclear Information System (INIS)

    Zubrin, R.M.; Ribe, F.L.

    1989-01-01

    A numerical one-dimensional solution of the Euler equations for an imploding spherical tungsten shell with internal deuterium-tritium gas is applied to study impact-fusion dynamics with parameters of fusion reactor relevance. Thermal conduction and radiative energy loss by the plasma are taken into account, as is heating by fusion generated alpha particles. A variety of target sizes and impact velocities are examined, and scaling laws for fusion yields are deduced which define possible parameters for conceptual commercial impact-fusion power reactors. It is found that shell energies and velocities of about 30 MJ and 110 km/s would be satisfactory. A commercial impact-fusion reactor based on such parameters is discussed

  8. Fault size classification of rotating machinery using support vector machine

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Y. S.; Lee, D. H.; Park, S. K. [Korea Hydro and Nuclear Power Co. Ltd., Daejeon (Korea, Republic of)

    2012-03-15

    Studies on fault diagnosis of rotating machinery have been carried out to obtain a machinery condition in two ways. First is a classical approach based on signal processing and analysis using vibration and acoustic signals. Second is to use artificial intelligence techniques to classify machinery conditions into normal or one of the pre-determined fault conditions. Support Vector Machine (SVM) is well known as intelligent classifier with robust generalization ability. In this study, a two-step approach is proposed to predict fault types and fault sizes of rotating machinery in nuclear power plants using multi-class SVM technique. The model firstly classifies normal and 12 fault types and then identifies their sizes in case of predicting any faults. The time and frequency domain features are extracted from the measured vibration signals and used as input to SVM. A test rig is used to simulate normal and the well-know 12 artificial fault conditions with three to six fault sizes of rotating machinery. The application results to the test data show that the present method can estimate fault types as well as fault sizes with high accuracy for bearing an shaft-related faults and misalignment. Further research, however, is required to identify fault size in case of unbalance, rubbing, looseness, and coupling-related faults.

  9. Fault size classification of rotating machinery using support vector machine

    International Nuclear Information System (INIS)

    Kim, Y. S.; Lee, D. H.; Park, S. K.

    2012-01-01

    Studies on fault diagnosis of rotating machinery have been carried out to obtain a machinery condition in two ways. First is a classical approach based on signal processing and analysis using vibration and acoustic signals. Second is to use artificial intelligence techniques to classify machinery conditions into normal or one of the pre-determined fault conditions. Support Vector Machine (SVM) is well known as intelligent classifier with robust generalization ability. In this study, a two-step approach is proposed to predict fault types and fault sizes of rotating machinery in nuclear power plants using multi-class SVM technique. The model firstly classifies normal and 12 fault types and then identifies their sizes in case of predicting any faults. The time and frequency domain features are extracted from the measured vibration signals and used as input to SVM. A test rig is used to simulate normal and the well-know 12 artificial fault conditions with three to six fault sizes of rotating machinery. The application results to the test data show that the present method can estimate fault types as well as fault sizes with high accuracy for bearing an shaft-related faults and misalignment. Further research, however, is required to identify fault size in case of unbalance, rubbing, looseness, and coupling-related faults

  10. Role of hydrodynamic instability growth in hot-spot mass gain and fusion performance of inertial confinement fusion implosions

    International Nuclear Information System (INIS)

    Srinivasan, Bhuvana; Tang, Xian-Zhu

    2014-01-01

    In an inertial confinement fusion target, energy loss due to thermal conduction from the hot-spot will inevitably ablate fuel ice into the hot-spot, resulting in a more massive but cooler hot-spot, which negatively impacts fusion yield. Hydrodynamic mix due to Rayleigh-Taylor instability at the gas-ice interface can aggravate the problem via an increased gas-ice interfacial area across which energy transfer from the hot-spot and ice can be enhanced. Here, this mix-enhanced transport effect on hot-spot fusion-performance degradation is quantified using contrasting 1D and 2D hydrodynamic simulations, and its dependence on effective acceleration, Atwood number, and ablation speed is identified

  11. Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans

    Energy Technology Data Exchange (ETDEWEB)

    Yasuda, Kayo [Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193 (Japan); Education and Research Support Center, Tokai University School of Medicine, Isehara, Kanagawa 259-1193 (Japan); Hartman, Philip S. [Biology Department, Texas Christian University, Fort Worth, TX 76129 (United States); Ishii, Takamasa [Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193 (Japan); Suda, Hitoshi [School of High-Technology for Human Welfare, Tokai University, Nishino 317, Numazu, Shizuoka 410-0395 (Japan); Akatsuka, Akira [Education and Research Support Center, Tokai University School of Medicine, Isehara, Kanagawa 259-1193 (Japan); Shoyama, Tetsuji [School of High-Technology for Human Welfare, Tokai University, Nishino 317, Numazu, Shizuoka 410-0395 (Japan); Miyazawa, Masaki [Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193 (Japan); Ishii, Naoaki, E-mail: nishii@is.icc.u-tokai.ac.jp [Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193 (Japan)

    2011-01-21

    Research highlights: {yields} Growth and development of a fzo-1 mutant defective in the fusion process of mitochondria was delayed relative to the wild type of Caenorhabditis elegans. {yields} Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type. {yields} fzo-1 animals had significantly lower metabolism than did N2 and mev-1 overproducing superoxide from mitochondrial electron transport complex II. {yields} Mitochondrial fusion can profoundly affect energy metabolism and development. -- Abstract: Mitochondria are known to be dynamic structures with the energetically and enzymatically mediated processes of fusion and fission responsible for maintaining a constant flux. Mitochondria also play a role of reactive oxygen species production as a byproduct of energy metabolism. In the current study, interrelationships between mitochondrial fusion, energy metabolism and oxidative stress on development were explored using a fzo-1 mutant defective in the fusion process and a mev-1 mutant overproducing superoxide from mitochondrial electron transport complex II of Caenorhabditis elegans. While growth and development of both single mutants was slightly delayed relative to the wild type, the fzo-1;mev-1 double mutant experienced considerable delay. Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type. fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development.

  12. Recyclable transmission line (RTL) and linear transformer driver (LTD) development for Z-pinch inertial fusion energy (Z-IFE) and high yield

    International Nuclear Information System (INIS)

    Sharpe, Robin Arthur; Kingsep, Alexander S.; Smith, David Lewis; Olson, Craig Lee; Ottinger, Paul F.; Schumer, Joseph Wade; Welch, Dale Robert; Kim, Alexander; Kulcinski, Gerald L.; Kammer, Daniel C.; Rose, David Vincent; Nedoseev, Sergei L.; Pointon, Timothy David; Smirnov, Valentin P.; Turgeon, Matthew C.; Kalinin, Yuri G.; Bruner, Nichelle

    2007-01-01

    Z-Pinch Inertial Fusion Energy (Z-IFE) complements and extends the single-shot z-pinch fusion program on Z to a repetitive, high-yield, power plant scenario that can be used for the production of electricity, transmutation of nuclear waste, and hydrogen production, all with no CO 2 production and no long-lived radioactive nuclear waste. The Z-IFE concept uses a Linear Transformer Driver (LTD) accelerator, and a Recyclable Transmission Line (RTL) to connect the LTD driver to a high-yield fusion target inside a thick-liquid-wall power plant chamber. Results of RTL and LTD research are reported here, that include: (1) The key physics issues for RTLs involve the power flow at the high linear current densities that occur near the target (up to 5 MA/cm). These issues include surface heating, melting, ablation, plasma formation, electron flow, magnetic insulation, conductivity changes, magnetic field diffusion changes, possible ion flow, and RTL mass motion. These issues are studied theoretically, computationally (with the ALEGRA and LSP codes), and will work at 5 MA/cm or higher, with anode-cathode gaps as small as 2 mm. (2) An RTL misalignment sensitivity study has been performed using a 3D circuit model. Results show very small load current variations for significant RTL misalignments. (3) The key structural issues for RTLs involve optimizing the RTL strength (varying shape, ribs, etc.) while minimizing the RTL mass. Optimization studies show RTL mass reductions by factors of three or more. (4) Fabrication and pressure testing of Z-PoP (Proof-of-Principle) size RTLs are successfully reported here. (5) Modeling of the effect of initial RTL imperfections on the buckling pressure has been performed. Results show that the curved RTL offers a much greater buckling pressure as well as less sensitivity to imperfections than three other RTL designs. (6) Repetitive operation of a 0.5 MA, 100 kV, 100 ns, LTD cavity with gas purging between shots and automated operation is

  13. Recyclable transmission line (RTL) and linear transformer driver (LTD) development for Z-pinch inertial fusion energy (Z-IFE) and high yield.

    Energy Technology Data Exchange (ETDEWEB)

    Sharpe, Robin Arthur; Kingsep, Alexander S. (Kurchatov Institute, Moscow, Russia); Smith, David Lewis; Olson, Craig Lee; Ottinger, Paul F. (Naval Research Laboratory, Washington, DC); Schumer, Joseph Wade (Naval Research Laboratory, Washington, DC); Welch, Dale Robert (Voss Scientific, Albuquerque, NM); Kim, Alexander (High Currents Institute, Tomsk, Russia); Kulcinski, Gerald L. (University of Wisconsin, Madison, WI); Kammer, Daniel C. (University of Wisconsin, Madison, WI); Rose, David Vincent (Voss Scientific, Albuquerque, NM); Nedoseev, Sergei L. (Kurchatov Institute, Moscow, Russia); Pointon, Timothy David; Smirnov, Valentin P. (Kurchatov Institute, Moscow, Russia); Turgeon, Matthew C.; Kalinin, Yuri G. (Kurchatov Institute, Moscow, Russia); Bruner, Nichelle " Nicki" (Voss Scientific, Albuquerque, NM); Barkey, Mark E. (University of Alabama, Tuscaloosa, AL); Guthrie, Michael (University of Wisconsin, Madison, WI); Thoma, Carsten (Voss Scientific, Albuquerque, NM); Genoni, Tom C. (Voss Scientific, Albuquerque, NM); Langston, William L.; Fowler, William E.; Mazarakis, Michael Gerrassimos

    2007-01-01

    Z-Pinch Inertial Fusion Energy (Z-IFE) complements and extends the single-shot z-pinch fusion program on Z to a repetitive, high-yield, power plant scenario that can be used for the production of electricity, transmutation of nuclear waste, and hydrogen production, all with no CO{sub 2} production and no long-lived radioactive nuclear waste. The Z-IFE concept uses a Linear Transformer Driver (LTD) accelerator, and a Recyclable Transmission Line (RTL) to connect the LTD driver to a high-yield fusion target inside a thick-liquid-wall power plant chamber. Results of RTL and LTD research are reported here, that include: (1) The key physics issues for RTLs involve the power flow at the high linear current densities that occur near the target (up to 5 MA/cm). These issues include surface heating, melting, ablation, plasma formation, electron flow, magnetic insulation, conductivity changes, magnetic field diffusion changes, possible ion flow, and RTL mass motion. These issues are studied theoretically, computationally (with the ALEGRA and LSP codes), and will work at 5 MA/cm or higher, with anode-cathode gaps as small as 2 mm. (2) An RTL misalignment sensitivity study has been performed using a 3D circuit model. Results show very small load current variations for significant RTL misalignments. (3) The key structural issues for RTLs involve optimizing the RTL strength (varying shape, ribs, etc.) while minimizing the RTL mass. Optimization studies show RTL mass reductions by factors of three or more. (4) Fabrication and pressure testing of Z-PoP (Proof-of-Principle) size RTLs are successfully reported here. (5) Modeling of the effect of initial RTL imperfections on the buckling pressure has been performed. Results show that the curved RTL offers a much greater buckling pressure as well as less sensitivity to imperfections than three other RTL designs. (6) Repetitive operation of a 0.5 MA, 100 kV, 100 ns, LTD cavity with gas purging between shots and automated operation is

  14. The Autophagic Machinery in Enterovirus Infection.

    Science.gov (United States)

    Lai, Jeffrey K F; Sam, I-Ching; Chan, Yoke Fun

    2016-01-27

    The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68. They cause a wide variety of diseases, ranging from mild to severe life-threatening diseases. Currently, no effective vaccine is available against enteroviruses except for poliovirus. Enteroviruses subvert the autophagic machinery to benefit their assembly, maturation, and exit from host. Some enteroviruses spread between cells via a process described as autophagosome-mediated exit without lysis (AWOL). The early and late phases of autophagy are regulated through various lipids and their metabolizing enzymes. Some of these lipids and enzymes are specifically regulated by enteroviruses. In the present review, we summarize the current understanding of the regulation of autophagic machinery by enteroviruses, and provide updates on recent developments in this field.

  15. Neutrons and fusion

    International Nuclear Information System (INIS)

    Maynard, C.W.

    1976-01-01

    The production of energy from fusion reactions does not require neutrons in the fundamental sense that they are required in a fission reactor. Nevertheless, the dominant fusion reaction, that between deuterium and tritium, yields a 14 MeV neutron. To contrast a fusion reactor based on this reaction with the fission case, 3 x 10 20 such neutrons produced per gigawatt of power. This is four times as many neutrons as in an equivalent fission reactor and they carry seven times the energy of the fission neutrons. Thus, they dominate the energy recovery problem and create technological problems comparable to the original plasma confinement problem as far as a practical power producing device is concerned. Further contrasts of the fusion and fission cases are presented to establish the general role of neutrons in fusion devices. Details of the energy deposition processes are discussed and those reactions necessary for producing additional tritium are outlined. The relatively high energy flux with its large intensity will activate almost any materials of which the reactor may be composed. This activation is examined from the point of view of decay heat, radiological safety, and long-term storage. In addition, a discussion of the deleterious effects of neutron interactions on materials is given in some detail; this includes the helium and hydrogen producing reactions and displacement rate of the lattice atoms. The various materials that have been proposed for structural purposes, for breeding, reflecting, and moderating neutrons, and for radiation shielding are reviewed from the nuclear standpoint. The specific reactions of interest are taken up for various materials and finally a report is given on the status and prospects of data for fusion studies

  16. A Survey of Fish Production and Processing Machinery in Rivers ...

    African Journals Online (AJOL)

    Survey of fish production and processing machinery in Port Harcourt City Local Government Area of Rivers State, Nigeria was carried out to evaluate the followings: different machines used for fish production and processing, the most acceptable machine, effect of cost of machinery on the fish farmer, whether gender has ...

  17. Electric power from laser fusion: the HYLIFE concept

    International Nuclear Information System (INIS)

    Monsler, M.; Blink, J.; Hovingh, J.; Meier, W.; Walker, P.; Maniscalco, J.

    1978-06-01

    A high yield lithium injection fusion energy chamber is described which can conceptually be operated with pulsed yields of several thousand megajoules a few times a second, using less than one percent of the gross thermal power to circulate the lithium. Because a one meter thick blanket of lithium protects the structure, no first wall replacement is envisioned for the life of the power plant. The induced radioactivity is reduced by an order of magnitude over solid blanket concepts. The design calls for the use of common ferritic steels and a power density approaching that of a LWR, promising shortened development times over other fusion concepts and reactor vessel costs comparable to a LMFBR

  18. Detection of Early Faults in Rotating Machinery Based on Wavelet Analysis

    Directory of Open Access Journals (Sweden)

    Meng Hee Lim

    2013-01-01

    Full Text Available This paper explores the application of wavelet analysis for the detection of early changes in rotor dynamics caused by common machinery faults, namely, rotor unbalance and minor blade rubbing conditions. In this paper, the time synchronised wavelet analysis method was formulated and its effectiveness to detect machinery faults at the early stage was evaluated based on signal simulation and experimental study. The proposed method provides a more standardised approach to visualise the current state of rotor dynamics of a rotating machinery by taking into account the effects of time shift, wavelet edge distortion, and system noise suppression. The experimental results showed that this method is able to reveal subtle changes of the vibration signal characteristics in both the frequency content distribution and the amplitude distortion caused by minor rotor unbalance and blade rubbing conditions. Besides, this method also appeared to be an effective tool to diagnose and to discriminate the different types of machinery faults based on the unique pattern of the wavelet contours. This study shows that the proposed wavelet analysis method is promising to reveal machinery faults at early stage as compared to vibration spectrum analysis.

  19. The prospect of laser fusion energy

    International Nuclear Information System (INIS)

    Yamanaka, C.

    2000-01-01

    The inertial confinement fusion research has developed remarkably in these 30 years, which enables us to scope the inertial fusion energy in the next century. The recent progress in the ICF is briefly reviewed. The GEKKO XII n d glass laser has succeeded to get the long cherished world's purpose that was to compress a D-T fuel up to 1000 times the normal density. The neutron yield was some what less than the expected value. The MJ laser system is under construction expecting to ignite and bum a fuel. The alternative way is to use a PW short pulse laser for the fast ignition. The inertial fusion energy strategy is described with economic overviews on IFE power plants. Various applications of IFE are summarized. (author)

  20. Peaceful Uses of Fusion

    Science.gov (United States)

    Teller, E.

    1958-07-03

    Applications of thermonuclear energy for peaceful and constructive purposes are surveyed. Developments and problems in the release and control of fusion energy are reviewed. It is pointed out that the future of thermonuclear power reactors will depend upon the construction of a machine that produces more electric energy than it consumes. The fuel for thermonuclear reactors is cheap and practically inexhaustible. Thermonuclear reactors produce less dangerous radioactive materials than fission reactors and, when once brought under control, are not as likely to be subject to dangerous excursions. The interaction of the hot plasma with magnetic fields opens the way for the direct production of electricity. It is possible that explosive fusion energy released underground may be harnessed for the production of electricity before the same feat is accomplished in controlled fusion processes. Applications of underground detonations of fission devices in mining and for the enhancement of oil flow in large low-specific-yield formations are also suggested.

  1. Optimization of Hydraulic Machinery Bladings by Multilevel CFD Techniques

    Directory of Open Access Journals (Sweden)

    Thum Susanne

    2005-01-01

    Full Text Available The numerical design optimization for complex hydraulic machinery bladings requires a high number of design parameters and the use of a precise CFD solver yielding high computational costs. To reduce the CPU time needed, a multilevel CFD method has been developed. First of all, the 3D blade geometry is parametrized by means of a geometric design tool to reduce the number of design parameters. To keep geometric accuracy, a special B-spline modification technique has been developed. On the first optimization level, a quasi-3D Euler code (EQ3D is applied. To guarantee a sufficiently accurate result, the code is calibrated by a Navier-Stokes recalculation of the initial design and can be recalibrated after a number of optimization steps by another Navier-Stokes computation. After having got a convergent solution, the optimization process is repeated on the second level using a full 3D Euler code yielding a more accurate flow prediction. Finally, a 3D Navier-Stokes code is applied on the third level to search for the optimum optimorum by means of a fine-tuning of the geometrical parameters. To show the potential of the developed optimization system, the runner blading of a water turbine having a specific speed n q = 41 1 / min was optimized applying the multilevel approach.

  2. The prospect for fusion energy with light ions

    International Nuclear Information System (INIS)

    Mehlhorn, T.A.; Adams, R.G.; Bailey, J.E.

    1998-01-01

    Intense ion beams may be the best option for an Inertial Fusion Energy (IFE) driver. While light ions may be the long-term pulsed power approach to IFE, the current economic climate is such that there is no urgency in developing fusion energy sources. Research on light ion beams at Sandia will be suspended at the end of this fiscal year in favor of z-pinches studying ICF target physics, high yield fusion, and stewardship issues. The authors document the status of light ion research and the understanding of the feasibility of scaling light ions to IFE

  3. Multiscale singular value manifold for rotating machinery fault diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Yi; Lu, BaoChun; Zhang, Deng Feng [School of Mechanical Engineering, Nanjing University of Science and Technology,Nanjing (United States)

    2017-01-15

    Time-frequency distribution of vibration signal can be considered as an image that contains more information than signal in time domain. Manifold learning is a novel theory for image recognition that can be also applied to rotating machinery fault pattern recognition based on time-frequency distributions. However, the vibration signal of rotating machinery in fault condition contains cyclical transient impulses with different phrases which are detrimental to image recognition for time-frequency distribution. To eliminate the effects of phase differences and extract the inherent features of time-frequency distributions, a multiscale singular value manifold method is proposed. The obtained low-dimensional multiscale singular value manifold features can reveal the differences of different fault patterns and they are applicable to classification and diagnosis. Experimental verification proves that the performance of the proposed method is superior in rotating machinery fault diagnosis.

  4. An accelerated beam-plasma neutron/proton source and early application of a fusion plasma

    International Nuclear Information System (INIS)

    Ohnishi, M.; Yoshikawa, K.; Yamamoto, Y.; Hoshino, C.; Masuda, K.; Miley, G.; Jurczyk, B.; Stubbers, R.; Gu, Y.

    1999-01-01

    We measured the number of the neutrons and protons produced by D-D reactions in an accelerated beam-plasma fusion and curried out the numerical simulations. The linear dependence of the neutron yield on a discharge current indicates that the fusion reactions occur between the background gas and the fast particles. i.e. charge exchanged neutrals and accelerated ions. The neutron yield divided by (fusion cross section x ion current x neutral gas pressure) still possesses the dependence of the 1.2 power of discharge voltage. which shows the fusion reactions are affected by the electrostatic potential built-up in the center. The measured proton birth profiles suggest the existence of a double potential well, which is supported by the numerical simulations. (author)

  5. Investigating the Effect of Cultivate Lines Direction, Bio-Fertilizer Nitroxin and Superabsorbent Materials on Yield and Yield Components of Broad Leaf Vetch (Vicia narbonensis)

    OpenAIRE

    E Latifinia; N Akbari; F Nazarian Firozabadi; S Heidari

    2017-01-01

    Introduction The excessive use of fertilizers has caused severe damages to the bio-cycle in the fields and has destroyed the sustainable agricultural machinery. These destructive effects have led to the recommended use of bio-fertilizers. Biodiversity is one of the key sources of supplying nutrients in sustainable agriculture. The use of biological fertilizers in a sustainable agricultural system leads to sustained yield in plant production. Biological fertilizer of nitroxin has increased ...

  6. Suppressor of fusion, a Fusarium oxysporum homolog of Ndt80, is required for nutrient-dependent regulation of anastomosis.

    Science.gov (United States)

    Shahi, Shermineh; Fokkens, Like; Houterman, Petra M; Rep, Martijn

    2016-10-01

    Heterokaryon formation is an essential step in asexual recombination in Fusarium oxysporum. Filamentous fungi have an elaborate nonself recognition machinery to prevent formation and proliferation of heterokaryotic cells, called heterokaryon incompatibility (HI). In F. oxysporum the regulation of this machinery is not well understood. In Neurospora crassa, Vib-1, a putative transcription factor of the p53-like Ndt80 family of transcription factors, has been identified as global regulator of HI. In this study we investigated the role of the F. oxysporum homolog of Vib-1, called Suf, in vegetative hyphal and conidial anastomosis tube (CAT) fusion and HI. We identified a novel function for an Ndt80 homolog as a nutrient-dependent regulator of anastomosis. Strains carrying the SUF deletion mutation display a hyper-fusion phenotype during vegetative growth as well as germling development. In addition, conidial paring of incompatible SUF deletion strains led to more heterokaryon formation, which is independent of suppression of HI. Our data provides further proof for the divergence in the functions of different members Ndt80 family. We propose that Ndt80 homologs mediate responses to nutrient quality and quantity, with specific responses varying between species. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. STUDY OF THE PARAMETERS OF EFFICIENCY IN CENTRES FOR REPAIR OF AGRICULTURAL MACHINERY

    Directory of Open Access Journals (Sweden)

    Natalia Stoyanova

    2015-06-01

    Full Text Available The paper makes a thorough study of the parameters of efficiency in the centers for the repair of agricultural machinery, considering production and technological structure, the basic principles for design of the process of service, the quantitative indicators for servicing. It presents a theoretical model for the management of services in the service business, taking into account the basic system requirements for maintenance of agricultural machinery, the main elements of the standards of customer service, choice of forms for maintenance of agricultural machinery. Opportunities are proposed for the optimization of repair activities in the centers for repair of agricultural machinery.

  8. Condition Monitoring of Machinery in Non-Stationary Operations : Proceedings of the Second International Conference "Condition Monitoring of Machinery in Non-Stationnary Operations"

    CERN Document Server

    Bartelmus, Walter; Chaari, Fakher; Zimroz, Radoslaw; Haddar, Mohamed

    2012-01-01

    Condition monitoring of machines in non-stationary operations (CMMNO) can be seen as the major challenge for research in the field of machinery diagnostics. Condition monitoring of machines in non-stationary operations is the title of the presented book and the title of the Conference held in Hammamet - Tunisia March 26 – 28, 2012. It is the second conference under this title, first took place in Wroclaw - Poland , March 2011. The subject CMMNO comes directly from industry needs and observation of real objects. Most monitored and diagnosed objects used in industry works in non-stationary operations condition. The non-stationary operations come from fulfillment of machinery tasks, for which they are designed for. All machinery used in different kind of mines, transport systems, vehicles like: cars, buses etc, helicopters, ships and battleships and so on work in non-stationary operations. The papers included in the book are shaped by the organizing board of the conference and authors of the papers. The papers...

  9. Design and Realization of Rotating Machinery Conditions Monitoring System Based on Labview

    Science.gov (United States)

    Fan, Qiyuan

    Nonlinear dynamic analysis of rotating machinery system has always been the hot spot of the rotational dynamics research. This article sets up a rotating machinery condition monitoring system to realize the measurement of system dynamic characteristic parameters based on NI(National Instruments) virtual instruments technology. The measurement of vibration signal of rotating machinery system is achieved by using NI company general data acquisition module of NI company. Meanwhile, by analyzing and processing the acquired data using Labview 2012, the dynamic characteristics, such as .the speed of the rotating machinery system, the axis trajectory, spectrum parameters, are attained. The measurement results show that the rotating machinery condition monitoring system based on Labview is easy to operate, easy to realize the function extension and maintenance, and that it can be used in the industrial engineering projects with rotation characteristics. Labview as the development tools used by virtual instrument function, is very powerful data acquisition software products support is one of the features of it, so using Labview programming and data acquisition is simple and convenient [1].

  10. Emergence and modular evolution of a novel motility machinery in bacteria.

    Directory of Open Access Journals (Sweden)

    Jennifer Luciano

    2011-09-01

    Full Text Available Bacteria glide across solid surfaces by mechanisms that have remained largely mysterious despite decades of research. In the deltaproteobacterium Myxococcus xanthus, this locomotion allows the formation stress-resistant fruiting bodies where sporulation takes place. However, despite the large number of genes identified as important for gliding, no specific machinery has been identified so far, hampering in-depth investigations. Based on the premise that components of the gliding machinery must have co-evolved and encode both envelope-spanning proteins and a molecular motor, we re-annotated known gliding motility genes and examined their taxonomic distribution, genomic localization, and phylogeny. We successfully delineated three functionally related genetic clusters, which we proved experimentally carry genes encoding the basal gliding machinery in M. xanthus, using genetic and localization techniques. For the first time, this study identifies structural gliding motility genes in the Myxobacteria and opens new perspectives to study the motility mechanism. Furthermore, phylogenomics provide insight into how this machinery emerged from an ancestral conserved core of genes of unknown function that evolved to gliding by the recruitment of functional modules in Myxococcales. Surprisingly, this motility machinery appears to be highly related to a sporulation system, underscoring unsuspected common mechanisms in these apparently distinct morphogenic phenomena.

  11. A lower cost development path for heavy ion fusion

    International Nuclear Information System (INIS)

    Hogan, W.J.; Meier, W.R.

    1993-01-01

    If two features of the inertial fusion process are exploited successfully, they can lead to significantly lower costs for demonstrating the feasibility of commercial electric power production from this source of energy. First, fusion capsule ignition and burn physics is independent of reaction chamber size and hydrodynamically-equivalent capsules can be designed to perform at small yield, exactly as they do at large yield. This means that an integrated test of all power plant components and feasibility tests of various reaction chamber concepts can be done at much smaller sizes (about 1--2 m first wall radius) and much lower powers (tens of MWs) than magnetic fusion development facilities such as ITER. Second, the driver, which is the most expensive component of currently conceived IFE development facilities, can be used to support more than one experiment target chamber/reactor (simultaneously and/or sequentially). These two factors lead to lower development facility costs, modular facilities, and the planning flexibility to spread costs over time or do several things in parallel and thus shorten the total time needed for development of Inertial Fusion Energy (IFE). In this paper the authors describe the general feature of a heavy ion fusion development plan that takes advantage of upgradable accelerators and the ability to test chambers and reactor systems at small scale in order to reduce development time and costs

  12. 46 CFR 169.631 - Separation of machinery and fuel tank spaces from accommodation spaces.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Separation of machinery and fuel tank spaces from accommodation spaces. 169.631 Section 169.631 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... machinery and fuel tank spaces from accommodation spaces. (a) Machinery and fuel tank spaces must be...

  13. Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming.

    Science.gov (United States)

    Powell, Anne E; Anderson, Eric C; Davies, Paige S; Silk, Alain D; Pelz, Carl; Impey, Soren; Wong, Melissa H

    2011-02-15

    The most deadly phase in cancer progression is attributed to the inappropriate acquisition of molecular machinery leading to metastatic transformation and spread of disease to distant organs. Although it is appreciated that metastasis involves epithelial-mesenchymal interplay, the underlying mechanism defining this process is poorly understood. Specifically, how cancer cells evade immune surveillance and gain the ability to navigate the circulatory system remains a focus. One possible mechanism underlying metastatic conversion is fusion between blood-derived immune cells and cancer cells. While this notion is a century old, in vivo evidence that cell fusion occurs within tumors and imparts genetic or physiologic changes remains controversial. We have previously demonstrated in vivo cell fusion between blood cells and intestinal epithelial cells in an injury setting. Here, we hypothesize that immune cells, such as macrophages, fuse with tumor cells imparting metastatic capabilities by transferring their cellular identity. We used parabiosis to introduce fluorescent-labeled bone marrow-derived cells to mice with intestinal tumors, finding that fusion between circulating blood-derived cells and tumor epithelium occurs during the natural course of tumorigenesis. Moreover, we identify the macrophage as a key cellular partner for this process. Interestingly, cell fusion hybrids retain a transcriptome identity characteristic of both parental derivatives, while also expressing a unique subset of transcripts. Our data supports the novel possibility that tumorigenic cell fusion may impart physical behavior attributed to migratory macrophages, including navigation of circulation and immune evasion. As such, cell fusion may represent a promising novel mechanism underlying the metastatic conversion of cancer cells. ©2011 AACR.

  14. Development of a Portable Fusion Neutron Generator

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Byung-Hoon; In, Sang-Ryul; Jin, Jeong-Tae; Chang, Dae-Sik; Jang, Doh-Yun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Cheol Ho [Hanyang Univ., Seoul (Korea, Republic of)

    2015-05-15

    For this purpose commercial ones, fast neutron yield from 10{sup 7} to 10{sup 11}, are supplied by several companies and research groups around the world. But internally the following limits make it difficult to develop the related application systems by domestic companies and/or research groups. - Limited life time - High price - Frequent trouble Not only to remove these limits but also to find out new internal application fields, it is necessary to develop our own domestic neutron generators. With the related technologies earned during fusion related researches, we did start to develop movable neutron generators from small one to big one, which could cover different fusion neutron yields. In this presentation the design and initial experimental results on the developed small neutron generator with a final target of 10{sup 8} n/s of 14 MeV neutrons, will be summarized.

  15. A Selective Assay to Detect Chitin and Biologically Active Nano-Machineries for Chitin-Biosynthesis with Their Intrinsic Chitin-Synthase Molecules

    Directory of Open Access Journals (Sweden)

    Hildgund Schrempf

    2010-09-01

    Full Text Available A new assay system for chitin has been developed. It comprises the chitin-binding protein ChbB in fusion with a His-tag as well as with a Strep-tag, the latter of which was chemically coupled to horseradish peroxidase. With the resulting complex, minimal quantities of chitin are photometrically detectable. In addition, the assay allows rapid scoring of the activity of chitin-synthases. As a result, a refined procedure for the rapid purification of yeast chitosomes (nano-machineries for chitin biosynthesis has been established. Immuno-electronmicroscopical studies of purified chitosomes, gained from a yeast strain carrying a chitin-synthase gene fused to that for GFP (green-fluorescence protein, has led to the in situ localization of chitin-synthase-GFP molecules within chitosomes.

  16. 46 CFR 177.620 - Ventilation of machinery and fuel tank spaces.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Ventilation of machinery and fuel tank spaces. 177.620... fuel tank spaces. In addition to the requirements of this subpart, ventilation systems for spaces containing machinery or fuel tanks must comply with the requirements of part 182 of this chapter. ...

  17. Progress on z-pinch inertial fusion energy

    International Nuclear Information System (INIS)

    Olson, C.; Rochau, G.; Matzen, M.K.

    2005-01-01

    The goal of z-pinch inertial fusion energy (IFE) is to extend the single-shot z-pinch inertial confinement fusion (ICF) results on Z to a repetitive-shot z-pinch power plant concept for the economical production of electricity. Z produces up to 1.8 MJ of x-rays at powers as high as 230 TW. Recent target experiments on Z have demonstrated capsule implosion convergence ratios of 14-21 with a double-pinch driven target, and DD neutron yields up to 8x10exp10 with a dynamic hohlraum target. For z-pinch IFE, a power plant concept is discussed that uses high-yield IFE targets (3 GJ) with a low rep-rate per chamber (0.1 Hz). The concept includes a repetitive driver at 0.1 Hz, a Recyclable Transmission Line (RTL) to connect the driver to the target, high-yield targets, and a thick-liquid wall chamber. Recent funding by a U.S. Congressional initiative for $4M for FY04 is supporting research on RTLs, repetitive pulsed power drivers, shock mitigation, full RTL cycle planned experiments, high-yield IFE targets, and z-pinch power plant technologies. Recent results of research in all of these areas are discussed, and a Road Map for Z-Pinch IFE is presented. (author)

  18. Knudsen and inverse Knudsen layer effect on tail ion distribution and fusion reactivity in inertial confinement fusion targets

    Science.gov (United States)

    McDevitt, C. J.; Tang, X.-Z.; Guo, Z.; Berk, H. L.

    2014-10-01

    A series of reduced models are used to study the fast ion tail in the vicinity of a transition layer between plasmas at disparate temperatures and densities, which is typical of the gas-pusher interface in inertial confinement fusion targets. Emphasis is placed on utilizing progressively more comprehensive models in order to identify the essential physics for computing the fast ion tail at energies comparable to the Gamow peak. The resulting fast ion tail distribution is subsequently used to compute the fusion reactivity as a function of collisionality and temperature. It is found that while the fast ion distribution can be significantly depleted in the hot spot, leading to a reduction of the fusion reactivity in this region, a surplus of fast ions is present in the neighboring cold region. The presence of this fast ion surplus in the neighboring cold region is shown to lead to a partial recovery of the fusion yield lost in the hot spot.

  19. Structural design of nuclear reactor machinery and equipment

    International Nuclear Information System (INIS)

    Hara, Hideki

    1992-01-01

    Since the machinery, equipment and piping which compose nuclear power station facilities are diverse, when those are designed, consideration is given sufficiently to the objective of use and the importance of the object machinery and equipment so that those can maintain the soundness over the design life. In this report, on the contents and the design standard in the design techniques for nuclear reactor machinery and equipment, the way of thinking is shown, taking an example of reactor pressure vessel which is stipulated as the vessel kind 1 in the 'Technical standard of structures and others regarding nuclear facilities for electric power generation', Notice No. 501 of the Ministry of International Trade and Industry. The reactor pressure vessel of 1350 MWe improved type BWR (ABWR) is used under the condition of 87.9 kg/cm 2 and 302 degC, and the inside diameter is about 7.2 m, the inside height is about 21 m, and the wall thickness is about 170 mm. The design standard for reactor pressure vessels and its way of thinking, breakdown prevention design and the design techniques for reactor pressure vessels are described. (K.I.)

  20. Image fusion tool: Validation by phantom measurements

    International Nuclear Information System (INIS)

    Zander, A.; Geworski, L.; Richter, M.; Ivancevic, V.; Munz, D.L.; Muehler, M.; Ditt, H.

    2002-01-01

    Aim: Validation of a new image fusion tool with regard to handling, application in a clinical environment and fusion precision under different acquisition and registration settings. Methods: The image fusion tool investigated allows fusion of imaging modalities such as PET, CT, MRI. In order to investigate fusion precision, PET and MRI measurements were performed using a cylinder and a body contour-shaped phantom. The cylinder phantom (diameter and length 20 cm each) contained spheres (10 to 40 mm in diameter) which represented 'cold' or 'hot' lesions in PET measurements. The body contour-shaped phantom was equipped with a heart model containing two 'cold' lesions. Measurements were done with and without four external markers placed on the phantoms. The markers were made of plexiglass (2 cm diameter and 1 cm thickness) and contained a Ga-Ge-68 core for PET and Vitamin E for MRI measurements. Comparison of fusion results with and without markers was done visually and by computer assistance. This algorithm was applied to the different fusion parameters and phantoms. Results: Image fusion of PET and MRI data without external markers yielded a measured error of 0 resulting in a shift at the matrix border of 1.5 mm. Conclusion: The image fusion tool investigated allows a precise fusion of PET and MRI data with a translation error acceptable for clinical use. The error is further minimized by using external markers, especially in the case of missing anatomical orientation. Using PET the registration error depends almost only on the low resolution of the data

  1. Targeting Cell Polarity Machinery to Exhaust Breast Cancer Stem Cells

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-15-1-0644 TITLE: Targeting Cell Polarity Machinery to Exhaust Breast Cancer Stem Cells PRINCIPAL INVESTIGATOR: Chun-Ju...Targeting Cell Polarity Machinery to Exhaust Breast Cancer Stem Cells 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-15-1-0644 5c. PROGRAM ELEMENT...Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Cancer stem cells (CSCs), a cell population with acquired perpetuating self-renewal properties which

  2. Assessment of ion kinetic effects in shock-driven inertial confinement fusion implosions using fusion burn imaging

    International Nuclear Information System (INIS)

    Rosenberg, M. J.; Séguin, F. H.; Rinderknecht, H. G.; Zylstra, A. B.; Li, C. K.; Sio, H.; Johnson, M. Gatu; Frenje, J. A.; Petrasso, R. D.; Amendt, P. A.; Wilks, S. C.; Pino, J.; Atzeni, S.; Hoffman, N. M.; Kagan, G.; Molvig, K.; Glebov, V. Yu.; Stoeckl, C.; Seka, W.; Marshall, F. J.

    2015-01-01

    The significance and nature of ion kinetic effects in D 3 He-filled, shock-driven inertial confinement fusion implosions are assessed through measurements of fusion burn profiles. Over this series of experiments, the ratio of ion-ion mean free path to minimum shell radius (the Knudsen number, N K ) was varied from 0.3 to 9 in order to probe hydrodynamic-like to strongly kinetic plasma conditions; as the Knudsen number increased, hydrodynamic models increasingly failed to match measured yields, while an empirically-tuned, first-step model of ion kinetic effects better captured the observed yield trends [Rosenberg et al., Phys. Rev. Lett. 112, 185001 (2014)]. Here, spatially resolved measurements of the fusion burn are used to examine kinetic ion transport effects in greater detail, adding an additional dimension of understanding that goes beyond zero-dimensional integrated quantities to one-dimensional profiles. In agreement with the previous findings, a comparison of measured and simulated burn profiles shows that models including ion transport effects are able to better match the experimental results. In implosions characterized by large Knudsen numbers (N K  ∼ 3), the fusion burn profiles predicted by hydrodynamics simulations that exclude ion mean free path effects are peaked far from the origin, in stark disagreement with the experimentally observed profiles, which are centrally peaked. In contrast, a hydrodynamics simulation that includes a model of ion diffusion is able to qualitatively match the measured profile shapes. Therefore, ion diffusion or diffusion-like processes are identified as a plausible explanation of the observed trends, though further refinement of the models is needed for a more complete and quantitative understanding of ion kinetic effects

  3. Assessment of ion kinetic effects in shock-driven inertial confinement fusion implosions using fusion burn imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, M. J., E-mail: mros@lle.rochester.edu; Séguin, F. H.; Rinderknecht, H. G.; Zylstra, A. B.; Li, C. K.; Sio, H.; Johnson, M. Gatu; Frenje, J. A.; Petrasso, R. D. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Amendt, P. A.; Wilks, S. C.; Pino, J. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Atzeni, S. [Dipartimento SBAI, Università di Roma “La Sapienza” and CNISM, Via A. Scarpa 14-16, I-00161 Roma (Italy); Hoffman, N. M.; Kagan, G.; Molvig, K. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Glebov, V. Yu.; Stoeckl, C.; Seka, W.; Marshall, F. J. [Laboratory for Laser Energetics, University of Rochester, Rochester, New York 14623 (United States); and others

    2015-06-15

    The significance and nature of ion kinetic effects in D{sup 3}He-filled, shock-driven inertial confinement fusion implosions are assessed through measurements of fusion burn profiles. Over this series of experiments, the ratio of ion-ion mean free path to minimum shell radius (the Knudsen number, N{sub K}) was varied from 0.3 to 9 in order to probe hydrodynamic-like to strongly kinetic plasma conditions; as the Knudsen number increased, hydrodynamic models increasingly failed to match measured yields, while an empirically-tuned, first-step model of ion kinetic effects better captured the observed yield trends [Rosenberg et al., Phys. Rev. Lett. 112, 185001 (2014)]. Here, spatially resolved measurements of the fusion burn are used to examine kinetic ion transport effects in greater detail, adding an additional dimension of understanding that goes beyond zero-dimensional integrated quantities to one-dimensional profiles. In agreement with the previous findings, a comparison of measured and simulated burn profiles shows that models including ion transport effects are able to better match the experimental results. In implosions characterized by large Knudsen numbers (N{sub K} ∼ 3), the fusion burn profiles predicted by hydrodynamics simulations that exclude ion mean free path effects are peaked far from the origin, in stark disagreement with the experimentally observed profiles, which are centrally peaked. In contrast, a hydrodynamics simulation that includes a model of ion diffusion is able to qualitatively match the measured profile shapes. Therefore, ion diffusion or diffusion-like processes are identified as a plausible explanation of the observed trends, though further refinement of the models is needed for a more complete and quantitative understanding of ion kinetic effects.

  4. Conceptual design of neutron diagnostic systems for fusion experimental reactor

    International Nuclear Information System (INIS)

    Iguchi, T.; Kaneko, J.; Nakazawa, M.

    1994-01-01

    Neutron measurement in fusion experimental reactors is very important for burning plasma diagnostics and control, monitoring of irradiation effects on device components, neutron source characterization for in-situ engineering tests, etc. A conceptual design of neutron diagnostic systems for an ITER-like fusion experimental reactor has been made, which consists of a neutron yield monitor, a neutron emission profile monitor and a 14-MeV spectrometer. Each of them is based on a unique idea to meet the required performances for full power conditions assumed at ITER operation. Micro-fission chambers of 235 U (and 238 U) placed at several poloidal angles near the first wall are adopted as a promising neutron yield monitor. A collimated long counter system using a 235 U fission chamber and graphite neutron moderators is also proposed to improve the calibration accuracy of absolute neutron yield determination

  5. Fault Diagnosis for Rotating Machinery: A Method based on Image Processing.

    Directory of Open Access Journals (Sweden)

    Chen Lu

    Full Text Available Rotating machinery is one of the most typical types of mechanical equipment and plays a significant role in industrial applications. Condition monitoring and fault diagnosis of rotating machinery has gained wide attention for its significance in preventing catastrophic accident and guaranteeing sufficient maintenance. With the development of science and technology, fault diagnosis methods based on multi-disciplines are becoming the focus in the field of fault diagnosis of rotating machinery. This paper presents a multi-discipline method based on image-processing for fault diagnosis of rotating machinery. Different from traditional analysis method in one-dimensional space, this study employs computing method in the field of image processing to realize automatic feature extraction and fault diagnosis in a two-dimensional space. The proposed method mainly includes the following steps. First, the vibration signal is transformed into a bi-spectrum contour map utilizing bi-spectrum technology, which provides a basis for the following image-based feature extraction. Then, an emerging approach in the field of image processing for feature extraction, speeded-up robust features, is employed to automatically exact fault features from the transformed bi-spectrum contour map and finally form a high-dimensional feature vector. To reduce the dimensionality of the feature vector, thus highlighting main fault features and reducing subsequent computing resources, t-Distributed Stochastic Neighbor Embedding is adopt to reduce the dimensionality of the feature vector. At last, probabilistic neural network is introduced for fault identification. Two typical rotating machinery, axial piston hydraulic pump and self-priming centrifugal pumps, are selected to demonstrate the effectiveness of the proposed method. Results show that the proposed method based on image-processing achieves a high accuracy, thus providing a highly effective means to fault diagnosis for

  6. Fault Diagnosis for Rotating Machinery: A Method based on Image Processing.

    Science.gov (United States)

    Lu, Chen; Wang, Yang; Ragulskis, Minvydas; Cheng, Yujie

    2016-01-01

    Rotating machinery is one of the most typical types of mechanical equipment and plays a significant role in industrial applications. Condition monitoring and fault diagnosis of rotating machinery has gained wide attention for its significance in preventing catastrophic accident and guaranteeing sufficient maintenance. With the development of science and technology, fault diagnosis methods based on multi-disciplines are becoming the focus in the field of fault diagnosis of rotating machinery. This paper presents a multi-discipline method based on image-processing for fault diagnosis of rotating machinery. Different from traditional analysis method in one-dimensional space, this study employs computing method in the field of image processing to realize automatic feature extraction and fault diagnosis in a two-dimensional space. The proposed method mainly includes the following steps. First, the vibration signal is transformed into a bi-spectrum contour map utilizing bi-spectrum technology, which provides a basis for the following image-based feature extraction. Then, an emerging approach in the field of image processing for feature extraction, speeded-up robust features, is employed to automatically exact fault features from the transformed bi-spectrum contour map and finally form a high-dimensional feature vector. To reduce the dimensionality of the feature vector, thus highlighting main fault features and reducing subsequent computing resources, t-Distributed Stochastic Neighbor Embedding is adopt to reduce the dimensionality of the feature vector. At last, probabilistic neural network is introduced for fault identification. Two typical rotating machinery, axial piston hydraulic pump and self-priming centrifugal pumps, are selected to demonstrate the effectiveness of the proposed method. Results show that the proposed method based on image-processing achieves a high accuracy, thus providing a highly effective means to fault diagnosis for rotating machinery.

  7. Modern principles used in conformity assessment of machinery from forestry sector

    Directory of Open Access Journals (Sweden)

    Antonov Anca Elena

    2017-01-01

    Full Text Available The paper is aiming to implement the general principles of risk prevention at employer’s level, with respect to occupational risks evaluation, the elimination of risk and accident factors, and information of workers which are using the machinery in the forestry sector. For the use of machinery in the forestry sector in terms of economic performance and a level of maximum safety, it is necessary to ensure the user guides set by the manufacturer in terms of commissioning, use and to provide appropriate safe working operations and interventions and to guarantee the technical and environmental requirements, including appropriate measures and means of protection against accidents and occupational disease. The impact of occupational risks for machinery used in this sector can be reduced through the application of modern principles in conformity assessment and certification and, where appropriate, through technical diagnostics and inspection, taking into account the provisions of the new Machinery Directive 2006/42 / EC which is imposing the obligation of manufacturer to implement conformity assessment procedures in accordance with the methods of assessment and verification of safety at the certification bodies, notified at the European Commission. The paper aims to develop modern technical tools for conformity assessment and verification of this category of machines used in the forestry sector that would provide prerequisite for increasing competitiveness of employers in the market economy. Applying these tools of modern technology for manufacturers and users of this category of machinery provides the necessary conditions for placing on the market of safe products with a appropriate safety level, in the intended using conditions, in order to guarantee the essential requirements for safety and health, technical and environmental conditions, including measures and means of protection. The result of this research is to develop technical tools needed to

  8. An optimized hydrogen target for muon catalyzed fusion

    Energy Technology Data Exchange (ETDEWEB)

    Gheisari, R., E-mail: gheisari@pgu.ac.i [Physics Department, Persian Gulf University, Bushehr 75169 (Iran, Islamic Republic of)

    2011-04-01

    This paper deals with the optimization of the processes involved in muon catalyzed fusion. Muon catalyzed fusion ({mu}CF) is studied in all layers of the solid hydrogen structure H/0.1%T+D{sub 2}+HD. The layer H/T acts as an emitter source of energetic t{mu} atoms, due to the so-called Ramsauer-Townsend effect. These t{mu} atoms are slowed down in the second layer (degrader) and are forced to take place nuclear fusion in HD. The degrader affects time evolution of t{mu} atomic beam. This effect has not been considered until now in {mu}CF-multilayered targets. Due to muon cycling and this effect, considerable reactions occur in the degrader. In our calculations, it is shown that the fusion yield equals 180{+-}1.5. It is possible to separate events that overlap in time.

  9. The accident analysis of mobile mine machinery in Indian opencast coal mines.

    Science.gov (United States)

    Kumar, R; Ghosh, A K

    2014-01-01

    This paper presents the analysis of large mining machinery related accidents in Indian opencast coal mines. The trends of coal production, share of mining methods in production, machinery deployment in open cast mines, size and population of machinery, accidents due to machinery, types and causes of accidents have been analysed from the year 1995 to 2008. The scrutiny of accidents during this period reveals that most of the responsible factors are machine reversal, haul road design, human fault, operator's fault, machine fault, visibility and dump design. Considering the types of machines, namely, dumpers, excavators, dozers and loaders together the maximum number of fatal accidents has been caused by operator's faults and human faults jointly during the period from 1995 to 2008. The novel finding of this analysis is that large machines with state-of-the-art safety system did not reduce the fatal accidents in Indian opencast coal mines.

  10. Densification of chipper harvested SRC using on-farm machinery

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, M.

    2003-07-01

    This report gives details of a project to density wood chips using on-farm machinery in order to avoid problems encountered in bulk handling and storage of low density short rotation cultivation (SRC) wood chips - especially as some customers can only accept baled material. Trials using different lengths of chips produced by a standard SRC harvester are described, and the failure to produce acceptable bales is reported. The potential cost of modifying equipment is deemed to make the baling of SRC chips using standard farm machinery currently not viable.

  11. Information Fusion of Conflicting Input Data

    Directory of Open Access Journals (Sweden)

    Uwe Mönks

    2016-10-01

    Full Text Available Sensors, and also actuators or external sources such as databases, serve as data sources in order to realise condition monitoring of industrial applications or the acquisition of characteristic parameters like production speed or reject rate. Modern facilities create such a large amount of complex data that a machine operator is unable to comprehend and process the information contained in the data. Thus, information fusion mechanisms gain increasing importance. Besides the management of large amounts of data, further challenges towards the fusion algorithms arise from epistemic uncertainties (incomplete knowledge in the input signals as well as conflicts between them. These aspects must be considered during information processing to obtain reliable results, which are in accordance with the real world. The analysis of the scientific state of the art shows that current solutions fulfil said requirements at most only partly. This article proposes the multilayered information fusion system MACRO (multilayer attribute-based conflict-reducing observation employing the μBalTLCS (fuzzified balanced two-layer conflict solving fusion algorithm to reduce the impact of conflicts on the fusion result. The performance of the contribution is shown by its evaluation in the scope of a machine condition monitoring application under laboratory conditions. Here, the MACRO system yields the best results compared to state-of-the-art fusion mechanisms. The utilised data is published and freely accessible.

  12. Information Fusion of Conflicting Input Data.

    Science.gov (United States)

    Mönks, Uwe; Dörksen, Helene; Lohweg, Volker; Hübner, Michael

    2016-10-29

    Sensors, and also actuators or external sources such as databases, serve as data sources in order to realise condition monitoring of industrial applications or the acquisition of characteristic parameters like production speed or reject rate. Modern facilities create such a large amount of complex data that a machine operator is unable to comprehend and process the information contained in the data. Thus, information fusion mechanisms gain increasing importance. Besides the management of large amounts of data, further challenges towards the fusion algorithms arise from epistemic uncertainties (incomplete knowledge) in the input signals as well as conflicts between them. These aspects must be considered during information processing to obtain reliable results, which are in accordance with the real world. The analysis of the scientific state of the art shows that current solutions fulfil said requirements at most only partly. This article proposes the multilayered information fusion system MACRO (multilayer attribute-based conflict-reducing observation) employing the μ BalTLCS (fuzzified balanced two-layer conflict solving) fusion algorithm to reduce the impact of conflicts on the fusion result. The performance of the contribution is shown by its evaluation in the scope of a machine condition monitoring application under laboratory conditions. Here, the MACRO system yields the best results compared to state-of-the-art fusion mechanisms. The utilised data is published and freely accessible.

  13. 49 CFR 393.130 - What are the rules for securing heavy vehicles, equipment and machinery?

    Science.gov (United States)

    2010-10-01

    ... heavy vehicles, equipment and machinery? (a) Applicability. The rules in this section apply to the transportation of heavy vehicles, equipment and machinery which operate on wheels or tracks, such as front end... heavy vehicles, equipment or machinery with crawler tracks or wheels. (1) In addition to the...

  14. Intelligence and the machinery of government: conceptualizing the intelligence community

    OpenAIRE

    Davies, PHJ

    2010-01-01

    This article argues that the failure to address intelligence agencies as public organizations part and parcel with the overt machinery of government constitutes a significant lacuna both in the specialist study of intelligence and the broader discipline of public administration studies. The role and status of intelligence institutions as aspects of the machinery of central government is examined, along with the prospects of certain key paradigms in the field for understanding those institutio...

  15. Vibration Feature Extraction and Analysis for Fault Diagnosis of Rotating Machinery-A Literature Survey

    OpenAIRE

    Saleem Riaz; Hassan Elahi; Kashif Javaid; Tufail Shahzad

    2017-01-01

    Safety, reliability, efficiency and performance of rotating machinery in all industrial applications are the main concerns. Rotating machines are widely used in various industrial applications. Condition monitoring and fault diagnosis of rotating machinery faults are very important and often complex and labor-intensive. Feature extraction techniques play a vital role for a reliable, effective and efficient feature extraction for the diagnosis of rotating machinery. Therefore, deve...

  16. Premises for use of fusion systems for actinide waste incineration

    International Nuclear Information System (INIS)

    Taczanowski, S.

    2007-01-01

    more economic devices. Yet, perhaps even more important advantages of the FDI system are: well homogeneous heating distribution and - first of all - reduced load of the First Wall (FW) with 14 MeV neutrons i.e. the main source of radiation damage. Simultaneously, the alpha yield from plasma to materials directly exposed to (e.g. the FW) is reduced, whereas the neutron yield attenuation reduces the gas production, DPA and the induced activity. Though instead of D-T neutrons the fission ones appear, but are much softer (below gas production thresholds) and in a much lesser number (ca.1/3). The performed calculations show that the plasma Q can be lessened to about 1 and the 14 MeV neutron yield even by a factor of ca. 30. Finally, it is emphasised that though the radiotoxicity gathered in the FDI system alone is larger than that in a fusion system free of fission waste, yet the whole radiotoxicity of the symbiotic nuclear energy system, i.e. consisted of a Fusion Driven incinerator of transuranics (Pu, Np and Am) received from associated Light Water Reactors is to be lower. In conclusion, the picture of hybrid option of fusion presented herewith as a means to solve the problems of both fission and fusion based nuclear energy should facilitate the development and then launching of the fusion power

  17. High voltage electrification of tractor and agricultural machinery – A review

    International Nuclear Information System (INIS)

    Moreda, G.P.; Muñoz-García, M.A.; Barreiro, P.

    2016-01-01

    Highlights: • CO_2 emission reduction calls for energy-efficient mobile work machines. • Energy recovery could be possible in some agricultural machinery operations. • Owning and operating costs of electrified tractor-implement pairs should be analyzed. • Plug-in hybrid electric tractors running along tramlines make sense. • Electrification allows for precise speed control, noise reduction and flexible design. - Abstract: Reduction of both pollutant emissions and fossil fuel dependency is an objective of energy policies worldwide. In many countries, governments promote the use of efficient vehicles like the hybrid electric vehicle. Incorporation of electric drives in tractor and agricultural machinery presents advantages in terms of increased energy efficiency and expanded functionalities. Higher efficiency means reduction in fuel consumption and subsequent decrease in CO_2 emission. New functionalities improve work quality and increase operator comfort. Tractor electrification takes advantage of decoupling loads and drives from the engine, which allows operating the latter at its highest efficiency point. Major advantages of machinery electrification are torque and speed control, noise reduction, and a more flexible design. In this paper, a review of the state-of-the-art of agricultural machinery high voltage electrification is presented.

  18. CCPIT Machinery Exhibition Succeeded in Kuala Lumpur

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ From August 18 to 20, 2005, China Council for the Promotion of International Trade(CCPIT) held China Machinery and Electronics Trade Exhibition, CME 2005 in Kuala Lumpur, the capital of Malaysia on behalf of China, a good job has been done.

  19. Information fusion under consideration of conflicting input signals

    CERN Document Server

    Mönks, Uwe

    2017-01-01

    This work proposes the multilayered information fusion system MACRO (multilayer attribute-based conflict-reducing observation) and the µBalTLCS (fuzzified balanced two-layer conflict solving) fusion algorithm to reduce the impact of conflicts on the fusion result. In addition, a sensor defect detection method, which is based on the continuous monitoring of sensor reliabilities, is presented. The performances of the contributions are shown by their evaluation in the scope of both a publicly available data set and a machine condition monitoring application under laboratory conditions. Here, the MACRO system yields the best results compared to state-of-the-art fusion mechanisms. The author Dr.-Ing. Uwe Mönks studied Electrical Engineering and Information Technology at the OWL University of Applied Sciences (Lemgo), Halmstad University (Sweden), and Aalborg University (Denmark). Since 2009 he is employed at the Institute Industrial IT (inIT) as research associate with project leading responsibilities. During th...

  20. Structural insights into the bacterial carbon - phosphorus lyase machinery

    DEFF Research Database (Denmark)

    Seweryn, Paulina; Van, Lan Bich; Kjeldgaard, Morten

    2015-01-01

    Phosphorus is required for all life and microorganisms can extract it from their environment through several metabolic pathways. When phosphate is in limited supply, some bacteria are able to use phosphonate compounds, which require specialized enzymatic machinery to break the stable carbon......–phosphorus (C–P) bond. Despite its importance, the details of how this machinery catabolizes phosphonates remain unknown. Here we determine the crystal structure of the 240-kilodalton Escherichia coli C–P lyase core complex (PhnG–PhnH–PhnI–PhnJ; PhnGHIJ), and show that it is a two-fold symmetric hetero...

  1. G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties.

    Science.gov (United States)

    Photowala, Huzefa; Blackmer, Trillium; Schwartz, Eric; Hamm, Heidi E; Alford, Simon

    2006-03-14

    Neurotransmitters are thought to be released as quanta, where synaptic vesicles deliver packets of neurotransmitter to the synaptic cleft by fusion with the plasma membrane. However, synaptic vesicles may undergo incomplete fusion. We provide evidence that G protein-coupled receptors inhibit release by causing such incomplete fusion. 5-hydroxytryptamine (5-HT) receptor signaling potently inhibits excitatory postsynaptic currents (EPSCs) between lamprey reticulospinal axons and their postsynaptic targets by a direct action on the vesicle fusion machinery. We show that 5-HT receptor-mediated presynaptic inhibition, at this synapse, involves a reduction in EPSC quantal size. Quantal size was measured directly by comparing unitary quantal amplitudes of paired EPSCs before and during 5-HT application and indirectly by determining the effect of 5-HT on the relationship between mean-evoked EPSC amplitude and variance. Results from FM dye-labeling experiments indicate that 5-HT prevents full fusion of vesicles. 5-HT reduces FM1-43 staining of vesicles with a similar efficacy to its effect on the EPSC. However, destaining of FM1-43-labeled vesicles is abolished by lower concentrations of 5-HT that leave a substantial EPSC. The use of a water-soluble membrane impermeant quenching agent in the extracellular space reduced FM1-43 fluorescence during stimulation in 5-HT. Thus vesicles contact the extracellular space during inhibition of synaptic transmission by 5-HT. We conclude that 5-HT, via free Gbetagamma, prevents the collapse of synaptic vesicles into the presynaptic membrane.

  2. Fusion rings and fusion ideals

    DEFF Research Database (Denmark)

    Andersen, Troels Bak

    by the so-called fusion ideals. The fusion rings of Wess-Zumino-Witten models have been widely studied and are well understood in terms of precise combinatorial descriptions and explicit generating sets of the fusion ideals. They also appear in another, more general, setting via tilting modules for quantum......This dissertation investigates fusion rings, which are Grothendieck groups of rigid, monoidal, semisimple, abelian categories. Special interest is in rational fusion rings, i.e., fusion rings which admit a finite basis, for as commutative rings they may be presented as quotients of polynomial rings...

  3. 46 CFR 167.65-60 - Examination of boilers and machinery by engineer.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Examination of boilers and machinery by engineer. 167.65-60 Section 167.65-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL... machinery by engineer. It shall be the duty of an engineer when he assumes charge of the boilers and...

  4. Variables affecting simulated Be sputtering yields

    Energy Technology Data Exchange (ETDEWEB)

    Björkas, C., E-mail: carolina.bjorkas@helsinki.fi; Nordlund, K.

    2013-08-15

    Since beryllium is a strong candidate for the main plasma-facing material in future fusion reactors, its sputtering behaviour plays an important role in predicting the reactor’s life-time. Consensus about the actual sputtering yields has not yet been achieved, as observations are influenced by experimental method and/or studied sample. In this work, the beryllium sputtering due to deuterium and beryllium self-bombardment is analyzed using molecular dynamics simulations. The main methodological aspects that influence the outcome, such as flux and fluence of the bombardment, are highlighted, and it is shown that the simulated yields also depend on the sample structure and deuterium content.

  5. Fault detection and diagnosis of an industrial steam turbine using fusion of SVM (support vector machine) and ANFIS (adaptive neuro-fuzzy inference system) classifiers

    Energy Technology Data Exchange (ETDEWEB)

    Salahshoor, Karim [Department of Instrumentation and Automation, Petroleum University of Technology, Tehran (Iran, Islamic Republic of); Kordestani, Mojtaba; Khoshro, Majid S. [Department of Control Engineering, Islamic Azad University South Tehran branch (Iran, Islamic Republic of)

    2010-12-15

    The subject of FDD (fault detection and diagnosis) has gained widespread industrial interest in machine condition monitoring applications. This is mainly due to the potential advantage to be achieved from reduced maintenance costs, improved productivity and increased machine availability. This paper presents a new FDD scheme for condition machinery of an industrial steam turbine using a data fusion methodology. Fusion of a SVM (support vector machine) classifier with an ANFIS (adaptive neuro-fuzzy inference system) classifier, integrated into a common framework, is utilized to enhance the fault detection and diagnostic tasks. For this purpose, a multi-attribute data is fused into aggregated values of a single attribute by OWA (ordered weighted averaging) operators. The simulation studies indicate that the resulting fusion-based scheme outperforms the individual SVM and ANFIS systems to detect and diagnose incipient steam turbine faults. (author)

  6. The status of 'cold fusion'

    International Nuclear Information System (INIS)

    Nagel, David J.

    1998-01-01

    The questions raised by reports of nuclear reactions at low energies, so called 'cold fusion', are not yet answered to the satisfaction of many scientists. Further experimental investigations of these and related questions seems desirable, at least for scientific if not practical reasons. Properly conducted, such investigations would be indistinguishable from normal research. They would yield information germane to accepted areas of scientific inquiry and technological utility

  7. Scoping of oil shale retorting with nuclear fusion reactors

    International Nuclear Information System (INIS)

    Galloway, T.R.

    1983-01-01

    An engineering scoping study was conducted at the U.S. Department of Energy's request to see if a feasible concept could be developed for using nuclear fusion heat to improve in situ extraction by retorting of underground oil shale. It was found that a fusion heated, oxygen-free inert gas could be used for driving modified, in situ retorts at a higher yield, using lower grade shale and producing less environmental problems than present-day processes. It was also found to be economically attractive with return on investments of 20 to 30%. Fusion blanket technology required was found to be reasonable at hot gas delivery temperatures of about650 0 C (920 K). The scale of a fusion reactor at 2.8 GW(thermal) producing 45 000 Mg/day (335 000 barrel/day) was also found to be reasonable

  8. CCPIT Machinery Exhibition Succeeded in Kuala Lumpur

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      From August 18 to 20, 2005, China Council for the Promotion of International Trade(CCPIT) held China Machinery and Electronics Trade Exhibition, CME 2005 in Kuala Lumpur, the capital of Malaysia on behalf of China, a good job has been done.……

  9. Web-based Interactive Simulator for Rotating Machinery.

    Science.gov (United States)

    Sirohi, Vijayalaxmi

    1999-01-01

    Baroma (Balance of Rotating Machinery), the Web-based educational engineering interactive software for teaching/learning combines didactical and software ergonomical approaches. The software in tutorial form simulates a problem using Visual Interactive Simulation in graphic display, and animation is brought about through graphical user interface…

  10. Study of fusion probabilities with halo nuclei using different proximity based potentials

    International Nuclear Information System (INIS)

    Kumari, Raj

    2013-01-01

    We study fusion of halo nuclei with heavy targets using proximity based potentials due to Aage Winther (AW) 95, Bass 80 and Proximity 2010. In order to consider the extended matter distribution of halo nuclei, the nuclei radii borrowed from cross section measurements are included in these potentials. Our study reveals that the barrier heights are effectively reduced and fusion cross sections are appreciably enhanced by including extended radii of these nuclei. We also find that the extended sizes of halos contribute towards enhancement of fusion probabilities in case of proton halo nuclei, but, contribute to transfer or break-up process rather than fusion yield in case of neutron halo nuclei

  11. Directional Wigner-Ville distribution and its application for rotating-machinery condition monitoring

    International Nuclear Information System (INIS)

    Kim, Dong Wan; Ha, Jae HOng; Shin, Hae Gon; Lee, Yoon Hee; Kim, Young Baik

    1996-01-01

    Vibration analysis is one of the most powerful tools available for the detection and isolation of incipient faults in mechanical systems. The methods of vibration analysis in use today and under continuous study are broad band vibration monitoring, time domain analysis, and frequency domain analysis. In recent years, great interest has been generated concerning the use of time-frequency representation and its application for a machinery diagnostics and condition monitoring system. The objective of the research described in this paper was to develop a new diagnostic tool for the rotating machinery. This paper introduces a new time-frequency representation, Directional Wigner-Ville Distribution, which analyses the time-frequency structure of the rotating machinery vibration

  12. ERGONOMIC AND ECOLOGICALSAFETY - FACTORSNESSARY TO IMPROVETHE COMPETITIVENESS OF THE DOMESTIC CONSTRUCTION MACHINERY

    Directory of Open Access Journals (Sweden)

    Volkov Andrey Anatol’evich

    2017-03-01

    Full Text Available The analysis of output and domestic used construction machinery showed that the most vulnerable link remains a problem of underreporting of ergonomics and environmental safety requirements. Compliance with ergonomic requirements enhances the performance of mechanized operations, leading to a decrease in construction costs. Increased environmental requirements reduce the negative impact on air basin. These results suggest the need to improve the structures of building machines. Made recommendations for a comprehensive solution to the problem. The measures to improve environmental safety, ergonomic design requirements of construction machinery, mechanisms of the optimal development of the domestic construction machinery, through the development and implementation of appropriate measures. Keywords: ergonomics of construction equipment, environmental safety of construction equipment

  13. Study of the influence of a delayed yielding phenomenon in magnetorheological damping devices on the vibration attenuation of a Jeffcott rotor

    Czech Academy of Sciences Publication Activity Database

    Zapoměl, Jaroslav; Ferfecki, P.

    2017-01-01

    Roč. 37, 2-5 (2017), s. 377-383 ISSN 0232-3869 R&D Projects: GA ČR GA15-06621S Institutional support: RVO:61388998 Keywords : magnetorheological dampers * rotors * delayed yielding Subject RIV: JR - Other Machinery OBOR OECD: Mechanical engineering

  14. A tensor and vector polarimeter for deuterons at fusion energies

    Energy Technology Data Exchange (ETDEWEB)

    Kroell, Leonard; Engels, Ralf; Gregoryev, Kyril; Mikirtychiants, Maxim; Mikirtychiants, Sergey; Rathmann, Frank; Stroeher, Hans [Institut fuer Kernphysik, Juelich Center for Hadron Physics, FZ Juelich (Germany); Kravtsov, Peter; Vasilyev, Alexander [High Energy Physics Department, PNPI (Russian Federation); Paetz, Hans [Institut fuer Kernphysik, Universitaet Koeln (Germany); Hebbeker, Thomas [III. Physikalisches Institut A, RWTH, Aachen (Germany)

    2010-07-01

    Within the framework of an ISTC project the fusion reactions of double-polarized deuterium (vector (d)+vector (d){yields} {sup 3}H+p, vector (d)+vector (d){yields} {sup 3}He+n) will be analysed in order to study the influence of the vector and tensor polarization of the initial projectiles on the total cross sections. These results allow a conclusion on the change of the branching ration between the two fusion channels and, therefore, the neutron reduction for a future generation of fusion reactor. The measurements request the knowledge of the polarization of the deuteron beam and of the (gas)target. With an unpolarized target, the beam polarization can be determined by measuring the angular distributions of the outgoing particles ({sup 3}He, p and {sup 3}H) with use of the known analysing powers. Vice versa, additional data for the analysing powers can be obtained with a beam of known polarization, measured with a Lamb-shift polarimeter. The setup of the charged ejectile polarimeters is described.

  15. 46 CFR 111.103-1 - Power ventilation systems except machinery space ventilation systems.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Power ventilation systems except machinery space ventilation systems. 111.103-1 Section 111.103-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Power ventilation systems except machinery space ventilation systems. Each power ventilation system must...

  16. Scoping of fusion-driven retorting of oil shale

    International Nuclear Information System (INIS)

    Galloway, T.R.

    1979-11-01

    In the time frame beyond 2005, fusion reactors are likely to make their first appearance when the oil shale industry will probably be operating with 20% of the production derived from surface retorts operating on deep mined shale from in situ retorts and 80% from shale retorted within these in situ retorts using relatively fine shale uniformly rubblized by expensive mining methods. A process was developed where fusion reactors supply a 600 0 C mixture of nitrogen, carbon dioxide, and water vapor to both surface and in situ retorts. The in situ production is accomplished by inert gas retorting, without oxygen, avoiding the burning of oil released from the larger shale particles produced in a simpler mining method. These fusion reactor-heated gases retort the oil from four 50x50x200m in-situ rubble beds at high rate of 40m/d and high yield (i.e., 95% F.A.), which provided high return on investment around 20% for the syncrude selling at $20/bbl, or 30% if sold as $30/bbl for heating oil. The bed of 600 0 C retorted shale, or char, left behind was then burned by the admission of ambient air in order to recover all of the possible energy from the shale resource. The hot combustion gases, mostly nitrogen, carbon dioxide and water vapor are then heat-exchanged with fusion reactor blanket coolant flow to be sequentially introduced into the next rubble bed ready for retorting. The advantages of this fusion-driven retorting process concept are a cheaper mining method, high yield and higher production rate system, processing with shale grades down to 50 l/mg (12 gpt), improved resource recovery by complete char utilization and low energy losses by leaving behind a cold, spent bed

  17. Alpha Heating and Burning Plasmas in Inertial Confinement Fusion.

    Science.gov (United States)

    Betti, R; Christopherson, A R; Spears, B K; Nora, R; Bose, A; Howard, J; Woo, K M; Edwards, M J; Sanz, J

    2015-06-26

    Estimating the level of alpha heating and determining the onset of the burning plasma regime is essential to finding the path towards thermonuclear ignition. In a burning plasma, the alpha heating exceeds the external input energy to the plasma. Using a simple model of the implosion, it is shown that a general relation can be derived, connecting the burning plasma regime to the yield enhancement due to alpha heating and to experimentally measurable parameters such as the Lawson ignition parameter. A general alpha-heating curve is found, independent of the target and suitable to assess the performance of all laser fusion experiments whether direct or indirect drive. The onset of the burning plasma regime inside the hot spot of current implosions on the National Ignition Facility requires a fusion yield of about 50 kJ.

  18. A Method of Rotating Machinery Fault Diagnosis Based on the Close Degree of Information Entropy

    Institute of Scientific and Technical Information of China (English)

    GENG Jun-bao; HUANG Shu-hong; JIN Jia-shan; CHEN Fei; LIU Wei

    2006-01-01

    This paper presents a method of rotating machinery fault diagnosis based on the close degree of information entropy. In the view of the information entropy, we introduce four information entropy features of the rotating machinery, which describe the vibration condition of the machinery. The four features are, respectively, denominated as singular spectrum entropy, power spectrum entropy, wavelet space state feature entropy and wavelet power spectrum entropy. The value scopes of the four information entropy features of the rotating machinery in some typical fault conditions are gained by experiments, which can be acted as the standard features of fault diagnosis. According to the principle of the shorter distance between the more similar models, the decision-making method based on the close degree of information entropy is put forward to deal with the recognition of fault patterns. We demonstrate the effectiveness of this approach in an instance involving the fault pattern recognition of some rotating machinery.

  19. Harnessing the respiration machinery for high-yield production of chemicals in metabolically engineered Lactococcus lactis

    DEFF Research Database (Denmark)

    Liu, Jianming; Wang, Zhihao; Kandasamy, Vijayalakshmi

    2017-01-01

    on metabolically engineered Lactococcus lactis strains to optimize the production of acetoin and (R,R)−2,3-butanediol (R-BDO). In the absence of an external electron acceptor, a surplus of two NADH per acetoin molecule is produced. We found that a fully activated respiration was able to efficiently regenerate NAD......+, and a high titer of 371 mM (32 g/L) of acetoin was obtained with a yield of 82% of the theoretical maximum. Subsequently, we extended the metabolic pathway from acetoin to R-BDO by introducing the butanediol dehydrogenase gene from Bacillus subtilis. Since one mole of NADH is consumed when acetoin...... is converted into R-BDO per mole, only the excess of NADH needs to be oxidized via respiration. Either by fine-tuning the respiration capacity or by using a dual-phase fermentation approach involving a switch from fully respiratory to non-respiratory conditions, we obtained 361 mM (32 g/L) R-BDO with a yield...

  20. Design of a fusion reaction-history measurement system with high temporal resolution

    International Nuclear Information System (INIS)

    Peng Xiaoshi; Wang Feng; Liu Shenye; Jiang Xiaohua; Tang Qi

    2010-01-01

    In order to accurately measure the history of fusion reaction for experimental study of inertial confinement fusion, we advance the design of a fusion reaction-history measurement system with high temporal resolution. The diagnostic system is composed of plastic scintillator and nose cone, an optical imaging system and the system of optic streak camera. Analyzing the capability of the system indicated that the instrument measured fusion reaction history at temporal resolution as low as 55ps and 40ps correspond to 2.45MeV DD neutrons and 14.03MeV DT neutrons. The instrument is able to measure the fusion reaction history at yields 1.5 x 10 9 DD neutrons, about 4 x 10 8 DT neutrons are required for a similar quality signal. (authors)

  1. Fault Diagnosis for Rotating Machinery Using Vibration Measurement Deep Statistical Feature Learning

    Directory of Open Access Journals (Sweden)

    Chuan Li

    2016-06-01

    Full Text Available Fault diagnosis is important for the maintenance of rotating machinery. The detection of faults and fault patterns is a challenging part of machinery fault diagnosis. To tackle this problem, a model for deep statistical feature learning from vibration measurements of rotating machinery is presented in this paper. Vibration sensor signals collected from rotating mechanical systems are represented in the time, frequency, and time-frequency domains, each of which is then used to produce a statistical feature set. For learning statistical features, real-value Gaussian-Bernoulli restricted Boltzmann machines (GRBMs are stacked to develop a Gaussian-Bernoulli deep Boltzmann machine (GDBM. The suggested approach is applied as a deep statistical feature learning tool for both gearbox and bearing systems. The fault classification performances in experiments using this approach are 95.17% for the gearbox, and 91.75% for the bearing system. The proposed approach is compared to such standard methods as a support vector machine, GRBM and a combination model. In experiments, the best fault classification rate was detected using the proposed model. The results show that deep learning with statistical feature extraction has an essential improvement potential for diagnosing rotating machinery faults.

  2. Fault Diagnosis for Rotating Machinery Using Vibration Measurement Deep Statistical Feature Learning.

    Science.gov (United States)

    Li, Chuan; Sánchez, René-Vinicio; Zurita, Grover; Cerrada, Mariela; Cabrera, Diego

    2016-06-17

    Fault diagnosis is important for the maintenance of rotating machinery. The detection of faults and fault patterns is a challenging part of machinery fault diagnosis. To tackle this problem, a model for deep statistical feature learning from vibration measurements of rotating machinery is presented in this paper. Vibration sensor signals collected from rotating mechanical systems are represented in the time, frequency, and time-frequency domains, each of which is then used to produce a statistical feature set. For learning statistical features, real-value Gaussian-Bernoulli restricted Boltzmann machines (GRBMs) are stacked to develop a Gaussian-Bernoulli deep Boltzmann machine (GDBM). The suggested approach is applied as a deep statistical feature learning tool for both gearbox and bearing systems. The fault classification performances in experiments using this approach are 95.17% for the gearbox, and 91.75% for the bearing system. The proposed approach is compared to such standard methods as a support vector machine, GRBM and a combination model. In experiments, the best fault classification rate was detected using the proposed model. The results show that deep learning with statistical feature extraction has an essential improvement potential for diagnosing rotating machinery faults.

  3. Pulsed fission/fusion hybrid engines

    International Nuclear Information System (INIS)

    Hudson, G.C.

    1979-01-01

    Research into high-thrust, high-specific impulse rocket engines using energy from nuclear reactions which has been conducted at this organization will be discussed. The engines are all conceptual in nature, yet are within the realization of conventional or near-term technology. The engine concepts under study at Foundation, Inc. are designed to obviate or minimize these negative effects of the ORION scheme. By using non-chemical triggers to initiate a non-breakeven fusion reaction at the core of a target composed of both fission and fusion fuel, it should be possible to employ the fusion neutrons thus produced to begin a fission reaction in U-235 or Pu-239. Since the density of the target can be increased by as much as a factor of 250 through compression of the pellet, the amount of fission material necessary to produce a critical mass can be greatly reduced. (This also means that the amount of fission products produced for a giventhrust level is also reduced from the ORION levels.) Coupling this eeffect to the large number of 14 MeV fusion neutrons produced early in the compression process and subsequently to the heating of some additional fusion fuel surrounding the critical mass leads to the very efficient burnup of the target. This insures both high yield from the target as well as low cost per MJ energy released. Finally, the use of such small pellets allows the scale of the energy released to be tailored to a level usable in rocket engines of a few tens of tons thrust level. (orig.) [de

  4. Conceptual design of a fast-ignition laser fusion reactor FALCON-D

    International Nuclear Information System (INIS)

    Goto, T.; Ogawa, Y.; Okano, K.; Hiwatari, R.; Asaoka, Y.; Someya, Y.; Sunahara, A.; Johzaki, T.

    2008-10-01

    A new conceptual design of the laser fusion power plant FALCON-D (Fast ignition Advanced Laser fusion reactor CONcept with a Dry wall chamber) has been proposed. The fast ignition method can achieve the sufficient fusion gain for a commercial operation (∼100) with about 10 times smaller fusion yield than the conventional central ignition method. FALCON-D makes full use of this property and aims at designing with a compact dry wall chamber (5 - 6 m radius). 1-D/2-D hydrodynamic simulations showed the possibility of the sufficient gain achievement with a 40 MJ target yield. The design feasibility of the compact dry wall chamber and solid breeder blanket system was shown through the thermomechanical analysis of the dry wall and neutronics analysis of the blanket system. A moderate electric output (∼400 MWe) can be achieved with a high repetition (30 Hz) laser. This dry wall concept not only reduces some difficulties accompanied with a liquid wall but also enables a simple cask maintenance method for the replacement of the blanket system, which can shorten the maintenance time. The basic idea of the maintenance method for the final optics system has also been proposed. Some critical R and D issues required for this design are also discussed. (author)

  5. Recent experimental results in sub- and near-barrier heavy-ion fusion reactions

    Energy Technology Data Exchange (ETDEWEB)

    Montagnoli, Giovanna [Dipartimento di Fisica e Astronomia, Universita di Padova (Italy); INFN Sezione di Padova (Italy); Stefanini, Alberto M. [INFN, Laboratori Nazionali di Legnaro, Legnaro (Padova) (Italy)

    2017-08-15

    Recent advances obtained in the field of near and sub-barrier heavy-ion fusion reactions are reviewed. Emphasis is given to the results obtained in the last decade, and focus is mainly on the experimental work performed concerning the influence of transfer channels on fusion cross sections and the hindrance phenomenon far below the barrier. Indeed, early data of sub-barrier fusion taught us that cross sections may strongly depend on the low-energy collective modes of the colliding nuclei, and, possibly, on couplings to transfer channels. The coupled-channels (CC) model has been quite successful in the interpretation of the experimental evidences. Fusion barrier distributions often yield the fingerprint of the relevant coupled channels. Recent results obtained by using radioactive beams are reported. At deep sub-barrier energies, the slope of the excitation function in a semi-logarithmic plot keeps increasing in many cases and standard CC calculations overpredict the cross sections. This was named a hindrance phenomenon, and its physical origin is still a matter of debate. Recent theoretical developments suggest that this effect, at least partially, may be a consequence of the Pauli exclusion principle. The hindrance may have far-reaching consequences in astrophysics where fusion of light systems determines stellar evolution during the carbon and oxygen burning stages, and yields important information for exotic reactions that take place in the inner crust of accreting neutron stars. (orig.)

  6. Performance of machinery in potato production in one growing season

    Directory of Open Access Journals (Sweden)

    Kun Zhou

    2015-12-01

    Full Text Available Statistics on the machinery performance are essential for farm managers to make better decisions. In this paper, the performance of all machineries in five sequential operations, namely bed forming, stone separation, planting, spraying and harvesting in the potato production system, were investigated during one growing season. In order to analyse and decompose the recorded GPS data into various time and distance elements for estimation of the machinery performance, an automatic GPS analysis tool was developed. The field efficiency and field capacity were estimated for each operation. Specifically, the measured average field efficiency was 71.3% for bed forming, 68.5% for stone separation, 40.3% for planting, 69.7% for spraying, and 67.4% for harvesting. The measured average field capacities were 1.46 ha/h, 0.53 ha/h, 0.47 ha/h, 10.21 ha/h, 0.51 ha/h, for the bed forming, stone separation, planting, spraying, and harvesting operations, respectively. These results deviate from the corresponding estimations calculated based on norm data from the American Society of Agricultural and Biological Engineers (ASABE. The deviations indicate that norms provided by ASABE cannot be used directly for the prediction of performance of the machinery used in this work. Moreover, the measured data of bed forming and stone separation could be used as supplementary data for the ASABE which does not provide performance norms for these two operations. The gained results can help farm managers to make better management and operational decisions that result in potential improvement in productivity and profitability as well as in potential environmental benefits.

  7. Performance of machinery in potato production in one growing season

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, K.; Jensen, A.L.; Bochtis, D.D.; Sørensen, C.G.

    2015-07-01

    Statistics on the machinery performance are essential for farm managers to make better decisions. In this paper, the performance of all machineries in five sequential operations, namely bed forming, stone separation, planting, spraying and harvesting in the potato production system, were investigated during one growing season. In order to analyse and decompose the recorded GPS data into various time and distance elements for estimation of the machinery performance, an automatic GPS analysis tool was developed. The field efficiency and field capacity were estimated for each operation. Specifically, the measured average field efficiency was 71.3% for bed forming, 68.5% for stone separation, 40.3% for planting, 69.7% for spraying, and 67.4% for harvesting. The measured average field capacities were 1.46 ha/h, 0.53 ha/h, 0.47 ha/h, 10.21 ha/h, 0.51 ha/h, for the bed forming, stone separation, planting, spraying, and harvesting operations, respectively. These results deviate from the corresponding estimations calculated based on norm data from the American Society of Agricultural and Biological Engineers (ASABE). The deviations indicate that norms provided by ASABE cannot be used directly for the prediction of performance of the machinery used in this work. Moreover, the measured data of bed forming and stone separation could be used as supplementary data for the ASABE which does not provide performance norms for these two operations. The gained results can help farm managers to make better management and operational decisions that result in potential improvement in productivity and profitability as well as in potential environmental benefits. (Author)

  8. Machinery and labour force requirements for forest chip production in Finland in 2020

    Energy Technology Data Exchange (ETDEWEB)

    Kaerhae, K.; Strandsroem, M. (Metsaeteho Oy, Helsinki (Finland)), Email: kalle.karha@metsateho.fi, Email: markus.strandstrom@metsateho.fi; Lahtinen, P.; Elo, J. (Poeyry Energy Oy, Espoo (Finland)), Email: perttu.lahtinen@poyry.com, Email: juha.elo@poyry.com

    2009-07-01

    The research carried out by Metsaeteho Oy and Poeyry Energy Oy estimated how much machinery and labour would be needed for large-scale forest chip production if the use of forest chips increases extensively in Finland during the coming decade. If the production and consumption of forest chips are 25 to 30 TWh in Finland 2020, then 1,900 to 2,200 machinery units, i.e. machines and trucks, would be needed. This would mean total investments in production machinery of 530 to 630 million euro (VAT 0 %). The labour demand would be 3,400 to 4,000 machine operators and drivers, and 4,200 to 5,100 labour years including indirect labour. Respectively, if the production and consumption of forest chips is 15 to 20 TWh in Finland in 2020, then the production machinery requirement would be 1,100 to 1,500 machines and trucks. The total machinery investment cost would be 320 to 420 million euro (VAT 0 %) and the calculated labour demand 2,000 to 2,700 machine operators and drivers (2,500 to 3,400 labour years). The results of the study indicated that forest chip production resources will be a major bottleneck in reaching the consumption target of 12 million m3, i.e. around 24 TWh of forest chips in Finland by 2020. (orig.)

  9. Spatiotemporal Regulation of Nuclear Transport Machinery and Microtubule Organization

    Science.gov (United States)

    Okada, Naoyuki; Sato, Masamitsu

    2015-01-01

    Spindle microtubules capture and segregate chromosomes and, therefore, their assembly is an essential event in mitosis. To carry out their mission, many key players for microtubule formation need to be strictly orchestrated. Particularly, proteins that assemble the spindle need to be translocated at appropriate sites during mitosis. A small GTPase (hydrolase enzyme of guanosine triphosphate), Ran, controls this translocation. Ran plays many roles in many cellular events: nucleocytoplasmic shuttling through the nuclear envelope, assembly of the mitotic spindle, and reorganization of the nuclear envelope at the mitotic exit. Although these events are seemingly distinct, recent studies demonstrate that the mechanisms underlying these phenomena are substantially the same as explained by molecular interplay of the master regulator Ran, the transport factor importin, and its cargo proteins. Our review focuses on how the transport machinery regulates mitotic progression of cells. We summarize translocation mechanisms governed by Ran and its regulatory proteins, and particularly focus on Ran-GTP targets in fission yeast that promote spindle formation. We also discuss the coordination of the spatial and temporal regulation of proteins from the viewpoint of transport machinery. We propose that the transport machinery is an essential key that couples the spatial and temporal events in cells. PMID:26308057

  10. Fission fragment yields from heavy-ion-induced reactions measured with a fragment separator

    Science.gov (United States)

    Tarasov, O. B.; Delaune, O.; Farget, F.; Morrissey, D. J.; Amthor, A. M.; Bastin, B.; Bazin, D.; Blank, B.; Cacéres, L.; Chbihi, A.; Fernández-Dominguez, B.; Grévy, S.; Kamalou, O.; Lukyanov, S. M.; Mittig, W.; Pereira, J.; Perrot, L.; Saint-Laurent, M.-G.; Savajols, H.; Sherrill, B. M.; Stodel, C.; Thomas, J. C.; Villari, A. C.

    2018-04-01

    The systematic study of fission fragment yields under different initial conditions has provided valuable experimental data for benchmarking models of fission product yields. Nuclear reactions using inverse kinematics coupled to the use of a high-resolution spectrometer with good fragment identification are shown here to be a powerful tool to measure the inclusive isotopic yields of fission fragments. In-flight fusion-fission was used in this work to produce secondary beams of neutron-rich isotopes in the collisions of a 238U beam at 24 MeV/u with 9Be and 12C targets at GANIL using the LISE3 fragment separator. Unique identification of the A, Z, and atomic charge state, q, of fission products was attained with the Δ E- TKE-B ρ- ToF measurement technique. Mass, and atomic number distributions are reported for the two reactions. The results show the importance of different reaction mechanisms in the two cases. The optimal target material for higher yields of neutron-rich high- Z isotopes produced in fusion-fission reactions as a function of projectile energy is discussed.

  11. Fusion of 8He with 206Pb around Coulomb barrier energies

    Directory of Open Access Journals (Sweden)

    Raabe R.

    2011-10-01

    Full Text Available The experimental study of the fusion of light neutron-rich nucleus 8He with 206Pb is reported in this work. A fusion stack of 206Pb targets has been used for this study. The most prominent evaporation residue (210Po, which has half-life of 138 days and decays by alpha emission, is populated in the reaction. Radiochemical analysis technique is used to extract the yield of this evaporation residue.

  12. Research on bearing fault diagnosis of large machinery based on mathematical morphology

    Science.gov (United States)

    Wang, Yu

    2018-04-01

    To study the automatic diagnosis of large machinery fault based on support vector machine, combining the four common faults of the large machinery, the support vector machine is used to classify and identify the fault. The extracted feature vectors are entered. The feature vector is trained and identified by multi - classification method. The optimal parameters of the support vector machine are searched by trial and error method and cross validation method. Then, the support vector machine is compared with BP neural network. The results show that the support vector machines are short in time and high in classification accuracy. It is more suitable for the research of fault diagnosis in large machinery. Therefore, it can be concluded that the training speed of support vector machines (SVM) is fast and the performance is good.

  13. Panel discussion: Progress and plans for magnetic fusion: Summary of comments on recent progress in fusion research at the Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Sheffield, J.

    1989-01-01

    Progress in fusion research is marked not so much by a few giant steps as by a continual number of small steps, which yield a steady advance toward the goal of producing a fusion reactor. During the past year, there have been two such steps in the Oak Ridge National Laboratory (ORNL) program: the experimental demonstration of access to the second stable region of beta in the Advanced Toroidal Facility (ATF); and the acceleration of a frozen hydrogen pellet by an intense electron beam. This paper discusses these steps

  14. Application of Choi—Williams Reduced Interference Time Frequency Distribution to Machinery Diagnostics

    Directory of Open Access Journals (Sweden)

    Howard A. Gaberson

    1995-01-01

    Full Text Available This article discusses time frequency analysis of machinery diagnostic vibration signals. The short time Fourier transform, the Wigner, and the Choi–Williams distributions are explained and illustrated with test cases. Examples of Choi—Williams analyses of machinery vibration signals are presented. The analyses detect discontinuities in the signals and their timing, amplitude and frequency modulation, and the presence of different components in a vibration signal.

  15. An Association of Unique microRNA Turnover Machinery with Prostate Cancer Progression

    Science.gov (United States)

    2017-10-01

    targeting of critical androgen receptor -604 coregulator interactions in prostate cancer . Nature communications 4, 1923, 605 doi:10.1038/ncomms2912 (2013...AWARD NUMBER: W81XWH-16-1-0474 TITLE: An Association of Unique microRNA Turnover Machinery with Prostate Cancer Progression PRINCIPAL INVESTIGATOR...14 Sep 2017 4. Title An Association of Unique microRNA Turnover Machinery with Prostate Cancer Progression 5a. CONTRACT NUMBER 5b. GRANT NUMBER

  16. Parameter study toward economical magnetic fusion power reactors

    International Nuclear Information System (INIS)

    Yoshida, Tomoaki; Okano, Kunihiko; Nanahara, Toshiya; Hatayama, Akiyoshi; Yamaji, Kenji; Takuma, Tadashi.

    1996-01-01

    Although the R and D of nuclear fusion reactors has made a steady progress as seen in ITER project, it has become of little doubt that fusion power reactors require hugeness and enormous amount of construction cost as well as surmounting the physics and engineering difficulties. Therefore, it is one of the essential issues to investigate the prospect of realizing fusion power reactors. In this report we investigated the effects of physics and engineering improvements on the economics of ITER-like steady state tokamak fusion reactors using our tokamak system and costing analysis code. With the results of this study, we considered what is the most significant factor for realizing economical competitive fusion reactors. The results show that with the conventional TF coil maximum field (12T), physics progress in β-value (or Troyon coefficient) has the most considerable effect on the reduction of fusion plant COE (Cost of Electricity) while the achievement of H factor = 2-3 and neutron wall load =∼5MW/m 2 is necessary. The results also show that with the improvement of TF coil maximum field, reactors with a high aspect ratio are economically advantageous because of low plasma current driving power while the improvement of current density in the conductors and yield strength of support structures is indispensable. (author)

  17. Molecular building blocks and their architecture in biologically/environmentally compatible soft matter chemical machinery.

    Science.gov (United States)

    Toyota, Taro; Banno, Taisuke; Nitta, Sachiko; Takinoue, Masahiro; Nomoto, Tomonori; Natsume, Yuno; Matsumura, Shuichi; Fujinami, Masanori

    2014-01-01

    This review briefly summarizes recent developments in the construction of biologically/environmentally compatible chemical machinery composed of soft matter. Since environmental and living systems are open systems, chemical machinery must continuously fulfill its functions not only through the influx and generation of molecules but also via the degradation and dissipation of molecules. If the degradation or dissipation of soft matter molecular building blocks and biomaterial molecules/polymers can be achieved, soft matter particles composed of them can be used to realize chemical machinery such as selfpropelled droplets, drug delivery carriers, tissue regeneration scaffolds, protocell models, cell-/tissuemarkers, and molecular computing systems.

  18. The RNAi Inheritance Machinery of Caenorhabditis elegans.

    Science.gov (United States)

    Spracklin, George; Fields, Brandon; Wan, Gang; Becker, Diveena; Wallig, Ashley; Shukla, Aditi; Kennedy, Scott

    2017-07-01

    Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel nematode-specific factors that we term here (heritable RNAi defective) HRDE-2 and HRDE-4 The new RNAi inheritance factors exhibit mortal germline (Mrt) phenotypes, which we show is likely caused by epigenetic deregulation in germ cells. We also show that HRDE-2 contributes to RNAi inheritance by facilitating the binding of small RNAs to the inheritance Argonaute (Ago) HRDE-1 Together, our results identify additional components of the RNAi inheritance machinery whose conservation provides insights into the molecular mechanism of RNAi inheritance, further our understanding of how the RNAi inheritance machinery promotes germline immortality, and show that HRDE-2 couples the inheritance Ago HRDE-1 with the small RNAs it needs to direct RNAi inheritance and germline immortality. Copyright © 2017 by the Genetics Society of America.

  19. Evaluation of fusion study from socio-economic aspects

    International Nuclear Information System (INIS)

    Konishi, S.; Okano, K.; Ogawa, Y.; Nagumo, S.; Tokimatsu, K.; Tobita, K.

    2005-01-01

    A fusion research project was evaluated from the aspects of socio-economics and its possible economic benefit. Research project itself has large economic impacts and it appears in a different way in different time. Four categories were identified as such mechanisms; direct economic effect by purchase and employment, the growth of local community and its economy, an improvement of technical capability of the industry stimulated by the development, and fusion energy supply under environmental constraints. Industrial effects were analysed from actual R and D program and found to yield considerable economic outcome, although contribution by the research itself is far smaller than that required for industry before actual commercial products can be produced. Economic value of fusion energy could be huge, but appears several decades future, and should be reduced by discount rate and success probability. Its value is more important as a part of environmental policy. Value of the fusion research at present age cannot be estimated as actual benefit, but as the effectiveness in the policy, or benefit for public that is now regarded as a kind of Externality

  20. Machinery health prognostics: A systematic review from data acquisition to RUL prediction

    Science.gov (United States)

    Lei, Yaguo; Li, Naipeng; Guo, Liang; Li, Ningbo; Yan, Tao; Lin, Jing

    2018-05-01

    Machinery prognostics is one of the major tasks in condition based maintenance (CBM), which aims to predict the remaining useful life (RUL) of machinery based on condition information. A machinery prognostic program generally consists of four technical processes, i.e., data acquisition, health indicator (HI) construction, health stage (HS) division, and RUL prediction. Over recent years, a significant amount of research work has been undertaken in each of the four processes. And much literature has made an excellent overview on the last process, i.e., RUL prediction. However, there has not been a systematic review that covers the four technical processes comprehensively. To fill this gap, this paper provides a review on machinery prognostics following its whole program, i.e., from data acquisition to RUL prediction. First, in data acquisition, several prognostic datasets widely used in academic literature are introduced systematically. Then, commonly used HI construction approaches and metrics are discussed. After that, the HS division process is summarized by introducing its major tasks and existing approaches. Afterwards, the advancements of RUL prediction are reviewed including the popular approaches and metrics. Finally, the paper provides discussions on current situation, upcoming challenges as well as possible future trends for researchers in this field.

  1. Availability analysis of selected mining machinery

    Directory of Open Access Journals (Sweden)

    Brodny Jarosław

    2017-06-01

    Full Text Available Underground extraction of coal is characterized by high variability of mining and geological conditions in which it is conducted. Despite ever more effective methods and tools, used to identify the factors influencing this process, mining machinery, used in mining underground, work in difficult and not always foreseeable conditions, which means that these machines should be very universal and reliable. Additionally, a big competition, occurring on the coal market, causes that it is necessary to take action in order to reduce the cost of its production, e.g. by increasing the efficiency of utilization machines. To meet this objective it should be pro-ceed with analysis presented in this paper. The analysis concerns to availability of utilization selected mining machinery, conducted using the model of OEE, which is a tool for quantitative estimate strategy TPM. In this article we considered the machines being part of the mechanized longwall complex and the basis of analysis was the data recording by the industrial automation system. Using this data set we evaluated the availability of studied machines and the structure of registered breaks in their work. The results should be an important source of information for maintenance staff and management of mining plants, needed to improve the economic efficiency of underground mining.

  2. Progress in the pulsed power Inertial Confinement Fusion program

    International Nuclear Information System (INIS)

    Quintenz, J.P.; Matzen, M.K.; Mehlhorn, T.A.

    1996-01-01

    Pulsed power accelerators are being used in Inertial Confinement Fusion (ICF) research. In order to achieve our goal of a fusion yield in the range of 200 - 1000 MJ from radiation-driven fusion capsules, it is generally believed that ∼10 MJ of driver energy must be deposited within the ICF target in order to deposit ∼1 MJ of radiation energy in the fusion capsule. Pulsed power represents an efficient technology for producing both these energies and these radiation environments in the required short pulses (few tens of ns). Two possible approaches are being developed to utilize pulsed power accelerators in this effort: intense beams of light ions and z- pinches. This paper describes recent progress in both approaches. Over the past several years, experiments have successfully answered many questions critical to ion target design. Increasing the ion beam power and intensity are our next objectives. Last year, the Particle Beam Fusion Accelerator H (PBFA II) was modified to generate ion beams in a geometry that will be required for high yield applications. This 2048 modification has resulted in the production of the highest power ion beam to be accelerated from an extraction ion diode. We are also evaluating fast magnetically-driven implosions (z-pinches) as platforms for ICF ablator physics and EOS experiments. Z-pinch implosions driven by the 20 TW Saturn accelerator have efficiently produced high x- ray power (> 75 TW) and energy (> 400 kJ). Containing these x-ray sources within a hohlraum produces a unique large volume (> 6000 mm 3 ), long lived (>20 ns) radiation environment. In addition to studying fundamental ICF capsule physics, there are several concepts for driving ICF capsules with these x-ray sources. Progress in increasing the x-ray power on the Saturn accelerator and promise of further increases on the higher power PBFA II accelerator will be described

  3. Multimodality Image Fusion and Planning and Dose Delivery for Radiation Therapy

    International Nuclear Information System (INIS)

    Saw, Cheng B.; Chen Hungcheng; Beatty, Ron E.; Wagner, Henry

    2008-01-01

    Image-guided radiation therapy (IGRT) relies on the quality of fused images to yield accurate and reproducible patient setup prior to dose delivery. The registration of 2 image datasets can be characterized as hardware-based or software-based image fusion. Hardware-based image fusion is performed by hybrid scanners that combine 2 distinct medical imaging modalities such as positron emission tomography (PET) and computed tomography (CT) into a single device. In hybrid scanners, the patient maintains the same position during both studies making the fusion of image data sets simple. However, it cannot perform temporal image registration where image datasets are acquired at different times. On the other hand, software-based image fusion technique can merge image datasets taken at different times or with different medical imaging modalities. Software-based image fusion can be performed either manually, using landmarks, or automatically. In the automatic image fusion method, the best fit is evaluated using mutual information coefficient. Manual image fusion is typically performed at dose planning and for patient setup prior to dose delivery for IGRT. The fusion of orthogonal live radiographic images taken prior to dose delivery to digitally reconstructed radiographs will be presented. Although manual image fusion has been routinely used, the use of fiducial markers has shortened the fusion time. Automated image fusion should be possible for IGRT because the image datasets are derived basically from the same imaging modality, resulting in further shortening the fusion time. The advantages and limitations of both hardware-based and software-based image fusion methodologies are discussed

  4. Comparison of Management-Operational Efficiency of Agricultural Machinery Operating Systems (Case Study Alborz Province

    Directory of Open Access Journals (Sweden)

    A Omidi

    2017-10-01

    Full Text Available Introduction Measuring the efficiency of operating systems in comparison with the methods of comparing the performance of systems explains the various dimensions of issues such as, the lack of full use of agricultural machinery capacity, improper selection of machine, incorrect use of machinery, ownership, etc.. Any improvement in operating system conditions reduces costs,, consumption of inputs, increases the efficiency of production factors and consequently reduces the price and increases agricultural profitability. The main objective of this research is to compare the operational-management efficiency of operating systems in Alborz province and comparison of managerial and operational efficiency of agricultural machinery farming systems by calculating the efficiency of its major components in agricultural machinery farming systems including efficiency, social, economic, technical-operational and managerial and ranking them in order to understand the optimal model of agricultural machinery systems. Materials and Methods This research is a survey study.The study population was beneficiaries of agricultural machinery in the Alborz province which in the multi-stage random sample was determined. Alborz province has 31,438 agricultural operations, of which 543 are exploited agricultural machinery. Cochran formula was used to determine sample size. Since, Cronbach's alpha coefficient greater than 0.7 was obtained by questionnaire, the reliability of the questionnaires was assessed as desirable. To calculate the efficiency the component data were extracted from 4 specialized questionnaires after the initial examination and encoding, then they were analyzed using the software SPSS, MCDM Engine. TOPSIS techniques were used for ranking managerial performance operating system for operating agricultural machinery Alborz province. Results and Discussion The results showed that social efficiency of dedicated-professional operation with an average of 6.6 had

  5. [Effects of heavy machinery operation on the structural characters of cultivated soils in black soil region of Northeast China].

    Science.gov (United States)

    Wang, En-Heng; Chai, Ya-Fan; Chen, Xiang-Wei

    2008-02-01

    With the cultivated soils in black soil region of Northeast China as test objects, this paper measured their structural characters such as soil strength, bulk density, and non-capillary porosity/capillary porosity (NCP/CP) ratio before and after heavy and medium-sized machinery operation, aimed to study the effects of machinery operation on the physical properties of test soils. The results showed that after machinery operation, there existed three distinct layers from top to bottom in the soil profiles, i.e., plowed layer, cumulative compacted layer, and non-affected layer, according to the changes of soil strength. Under medium-sized machinery operation, these three layers were shallower, and there was a new plow pan at the depth between 17.5 and 30 cm. Heavy machinery operation had significant positive effects on the improvement of topsoil structure (P heavy machinery, the bulk density of topsoil decreased by 7.2% and 3.5%, respectively, and NCP/CP increased by 556.6% after subsoiling, which would benefit water infiltration, reinforce water storage, and weaken the threat of soil erosion. The main action of heavy machinery operation was soil loosening, while that of medium-sized machinery operation was soil compacting.

  6. A GALA lipopeptide mediates pH- and membrane charge dependent fusion with stable giant unilamellar vesicles

    DEFF Research Database (Denmark)

    Etzerodt, Thomas P.; Trier, Sofie; Henriksen, Jonas R.

    2012-01-01

    sporadic and there is a strong need to characterize and increase our understanding of the membrane fusion properties of these peptides. Many fusion studies have focused on the ability of free peptides in solution that mediate fusion between liposomes. For drug delivery purposes it is a necessity to attach......,2-diamino propanoic acid (Dap) moiety, yielding the lipopeptide dimyristoyl-Dap-GALA (DMDGALA). We have investigated DMDGALA as a component in large unilamellar vesicles (LUVs) and demonstrate pH-triggered fusion of peptide containing LUVs with stable target giant unilamellar vesicles (GUVs), which were...

  7. On the reversed Brayton cycle with high speed machinery

    Energy Technology Data Exchange (ETDEWEB)

    Backman, J.

    1996-12-31

    This work was carried out in the laboratory of Fluid Dynamics, at Lappeenranta University of Technology during the years 1991-1996. The research was a part of larger high speed technology development research. First, there was the idea of making high speed machinery applications with the Brayton cycle. There was a clear need to deepen the knowledge of the cycle itself and to make a new approach in the field of the research. Also, the removal of water from the humid air seemed very interesting. The goal of this work was to study methods of designing high speed machinery for the reversed Brayton cycle, from theoretical principles to practical applications. The reversed Brayton cycle can be employed as an air dryer, a heat pump or a refrigerating machine. In this research the use of humid air as a working fluid has an environmental advantage, as well. A new calculation method for the Brayton cycle is developed. In this method especially the expansion process in the turbine is important because of the condensation of the water vapour in the humid air. This physical phenomena can have significant effects on the level of performance of the application. Also, the influence of calculating the process with actual, achievable process equipment efficiencies is essential for the development of future machinery. The above theoretical calculations are confirmed with two different laboratory prototypes. (53 refs.)

  8. On the reversed Brayton cycle with high speed machinery

    Energy Technology Data Exchange (ETDEWEB)

    Backman, J

    1997-12-31

    This work was carried out in the laboratory of Fluid Dynamics, at Lappeenranta University of Technology during the years 1991-1996. The research was a part of larger high speed technology development research. First, there was the idea of making high speed machinery applications with the Brayton cycle. There was a clear need to deepen the knowledge of the cycle itself and to make a new approach in the field of the research. Also, the removal of water from the humid air seemed very interesting. The goal of this work was to study methods of designing high speed machinery for the reversed Brayton cycle, from theoretical principles to practical applications. The reversed Brayton cycle can be employed as an air dryer, a heat pump or a refrigerating machine. In this research the use of humid air as a working fluid has an environmental advantage, as well. A new calculation method for the Brayton cycle is developed. In this method especially the expansion process in the turbine is important because of the condensation of the water vapour in the humid air. This physical phenomena can have significant effects on the level of performance of the application. Also, the influence of calculating the process with actual, achievable process equipment efficiencies is essential for the development of future machinery. The above theoretical calculations are confirmed with two different laboratory prototypes. (53 refs.)

  9. Methods for high yield production of terpenes

    Energy Technology Data Exchange (ETDEWEB)

    Kutchan, Toni; Higashi, Yasuhiro; Feng, Xiaohong

    2017-01-03

    Provided are enhanced high yield production systems for producing terpenes in plants via the expression of fusion proteins comprising various combinations of geranyl diphosphate synthase large and small subunits and limonene synthases. Also provided are engineered oilseed plants that accumulate monoterpene and sesquiterpene hydrocarbons in their seeds, as well as methods for producing such plants, providing a system for rapidly engineering oilseed crop production platforms for terpene-based biofuels.

  10. Self-assessed performance improves statistical fusion of image labels

    Energy Technology Data Exchange (ETDEWEB)

    Bryan, Frederick W., E-mail: frederick.w.bryan@vanderbilt.edu; Xu, Zhoubing; Asman, Andrew J.; Allen, Wade M. [Electrical Engineering, Vanderbilt University, Nashville, Tennessee 37235 (United States); Reich, Daniel S. [Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 (United States); Landman, Bennett A. [Electrical Engineering, Vanderbilt University, Nashville, Tennessee 37235 (United States); Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235 (United States); and Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37235 (United States)

    2014-03-15

    . Statistical fusion resulted in statistically indistinguishable performance from self-assessed weighted voting. The authors developed a new theoretical basis for using self-assessed performance in the framework of statistical fusion and demonstrated that the combined sources of information (both statistical assessment and self-assessment) yielded statistically significant improvement over the methods considered separately. Conclusions: The authors present the first systematic characterization of self-assessed performance in manual labeling. The authors demonstrate that self-assessment and statistical fusion yield similar, but complementary, benefits for label fusion. Finally, the authors present a new theoretical basis for combining self-assessments with statistical label fusion.

  11. Self-assessed performance improves statistical fusion of image labels

    International Nuclear Information System (INIS)

    Bryan, Frederick W.; Xu, Zhoubing; Asman, Andrew J.; Allen, Wade M.; Reich, Daniel S.; Landman, Bennett A.

    2014-01-01

    . Statistical fusion resulted in statistically indistinguishable performance from self-assessed weighted voting. The authors developed a new theoretical basis for using self-assessed performance in the framework of statistical fusion and demonstrated that the combined sources of information (both statistical assessment and self-assessment) yielded statistically significant improvement over the methods considered separately. Conclusions: The authors present the first systematic characterization of self-assessed performance in manual labeling. The authors demonstrate that self-assessment and statistical fusion yield similar, but complementary, benefits for label fusion. Finally, the authors present a new theoretical basis for combining self-assessments with statistical label fusion

  12. Absolute measurement of the DT primary neutron yield on the National Ignition Facility

    Directory of Open Access Journals (Sweden)

    Leeper R.J.

    2013-11-01

    Full Text Available The measurement of the absolute neutron yield produced in inertial confinement fusion target experiments conducted on the National Ignition Facility (NIF is essential in benchmarking progress towards the goal of achieving ignition on this facility. This paper describes three independent diagnostic techniques that have been developed to make accurate and precise DT neutron yield measurements on the NIF.

  13. Does heavy traffic have long term implications for crop yields?

    DEFF Research Database (Denmark)

    Nielsen, J. Aa.; Munkholm, Lars Juhl; Schjønning, Per

    Danish soils are subject to increasingly heavier traffic. Today, wheel loads of 6-12 tons are common on e.g. slurry tankers, combines and sugar beet harvesters. Field trials were started in Denmark in spring 2010 to answer the question: "does heavy traffic have long term implications for crop...... by the contractors delivering the machinery for the experimentation. Each year, spring barley (Hordeum vulgare L.) was established after the compaction treatments. s.ince 2013, investigations on biological tillage (root growth by pioneering crops) have been added to the trials. Significant yield losses up to 12.5 dt...

  14. Machinery fault diagnosis using joint global and local/nonlocal discriminant analysis with selective ensemble learning

    Science.gov (United States)

    Yu, Jianbo

    2016-11-01

    The vibration signals of faulty machine are generally non-stationary and nonlinear under those complicated working conditions. Thus, it is a big challenge to extract and select the effective features from vibration signals for machinery fault diagnosis. This paper proposes a new manifold learning algorithm, joint global and local/nonlocal discriminant analysis (GLNDA), which aims to extract effective intrinsic geometrical information from the given vibration data. Comparisons with other regular methods, principal component analysis (PCA), local preserving projection (LPP), linear discriminant analysis (LDA) and local LDA (LLDA), illustrate the superiority of GLNDA in machinery fault diagnosis. Based on the extracted information by GLNDA, a GLNDA-based Fisher discriminant rule (FDR) is put forward and applied to machinery fault diagnosis without additional recognizer construction procedure. By importing Bagging into GLNDA score-based feature selection and FDR, a novel manifold ensemble method (selective GLNDA ensemble, SE-GLNDA) is investigated for machinery fault diagnosis. The motivation for developing ensemble of manifold learning components is that it can achieve higher accuracy and applicability than single component in machinery fault diagnosis. The effectiveness of the SE-GLNDA-based fault diagnosis method has been verified by experimental results from bearing full life testers.

  15. The phototransduction machinery in the rod outer segment has a strong efficacy gradient

    KAUST Repository

    Mazzolini, Monica

    2015-05-04

    Rod photoreceptors consist of an outer segment (OS) and an inner segment. Inside the OS a biochemical machinery transforms the rhodopsin photoisomerization into electrical signal. This machinery has been treated as and is thought to be homogenous with marginal inhomogeneities. To verify this assumption, we developed a methodology based on special tapered optical fibers (TOFs) to deliver highly localized light stimulations. By using these TOFs, specific regions of the rod OS could be stimulated with spots of light highly confined in space. As the TOF is moved from the OS base toward its tip, the amplitude of saturating and single photon responses decreases, demonstrating that the efficacy of the transduction machinery is not uniform and is 5-10 times higher at the base than at the tip. This gradient of efficacy of the transduction machinery is attributed to a progressive depletion of the phosphodiesterase along the rod OS. Moreover we demonstrate that, using restricted spots of light, the duration of the photoresponse along the OS does not increase linearly with the light intensity as with diffuse light. © 2015, National Academy of Sciences. All rights reserved.

  16. Determination of the Jet Neutron Rate and Fusion Power using the Magnetic Proton Recoil Neutron Spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Sjoestrand, Henrik

    2003-01-01

    In this thesis a new independent method has been developed to enable precise measurements of neutron yields and rates from fusion plasmas and thereby determining the fusion power and fusion energy. The new method, together with the associated diagnostics, can provide information of great importance to present and future high fusion yield experiments, such as the Joint European Torus (JET) tokamak and the International Thermonuclear Experiment Reactor (ITER). The method has been applied to data from high fusion rate experiments from the tritium campaign at JET. By using the count-rate from the Magnetic Proton Recoil (MPR) neutron spectrometer the number of neutrons in the spectrometer's line of sight has been calculated. To be able to do this, all relevant factors between the plasma and the instrument have been evaluated. The number of neutrons in the MPR line of sight has been related to the total number of produced neutrons in the plasma by using information on the neutron emission profile. The achieved results have been compared with other JET neutron diagnostic data and the agreement is shown to be very good.

  17. Concept of a charged fusion product diagnostic for NSTX.

    Science.gov (United States)

    Boeglin, W U; Valenzuela Perez, R; Darrow, D S

    2010-10-01

    The concept of a new diagnostic for NSTX to determine the time dependent charged fusion product emission profile using an array of semiconductor detectors is presented. The expected time resolution of 1-2 ms should make it possible to study the effect of magnetohydrodynamics and other plasma activities (toroidal Alfvén eigenmodes (TAE), neoclassical tearing modes (NTM), edge localized modes (ELM), etc.) on the radial transport of neutral beam ions. First simulation results of deuterium-deuterium (DD) fusion proton yields for different detector arrangements and methods for inverting the simulated data to obtain the emission profile are discussed.

  18. In pursuit of fusion; ARGUS laser system at Livermore

    International Nuclear Information System (INIS)

    Simmons, W.W.

    1976-01-01

    The ARGUS laser facility has been developed to achieve significant laser fusion milestones; high density (greater than 10 g/cm 3 ) implosions, high temperature (greater than 10 KeV) implosions, and high yield from advanced target designs. The ARGUS laser, central to this facility is a twin-beam, 20 cm output aperture, Nd:glass solid state laser capable of delivering greater than 3 TW of power to laser fusion targets. At the present time, ARGUS is fully operational, and has produced up to 10 9 neutrons in selected target irradiation experiments. The performance of this facility is described

  19. Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.

    Science.gov (United States)

    Rival, Thomas; Macchi, Marc; Arnauné-Pelloquin, Laetitia; Poidevin, Mickael; Maillet, Frédéric; Richard, Fabrice; Fatmi, Ahmed; Belenguer, Pascale; Royet, Julien

    2011-03-01

    Mitochondria are highly dynamic organelles that can change in number and morphology during cell cycle, development or in response to extracellular stimuli. These morphological dynamics are controlled by a tight balance between two antagonistic pathways that promote fusion and fission. Genetic approaches have identified a cohort of conserved proteins that form the core of mitochondrial remodelling machineries. Mitofusins (MFNs) and OPA1 proteins are dynamin-related GTPases that are required for outer- and inner-mitochondrial membrane fusion respectively whereas dynamin-related protein 1 (DRP1) is the master regulator of mitochondrial fission. We demonstrate here that the Drosophila PMI gene and its human orthologue TMEM11 encode mitochondrial inner-membrane proteins that regulate mitochondrial morphogenesis. PMI-mutant cells contain a highly condensed mitochondrial network, suggesting that PMI has either a pro-fission or an anti-fusion function. Surprisingly, however, epistatic experiments indicate that PMI shapes the mitochondria through a mechanism that is independent of drp1 and mfn. This shows that mitochondrial networks can be shaped in higher eukaryotes by at least two separate pathways: one PMI-dependent and one DRP1/MFN-dependent.

  20. Non-machinery dialysis that achieves blood purification therapy without using full-scale dialysis machines.

    Science.gov (United States)

    Abe, Takaya; Onoda, Mistutaka; Matsuura, Tomohiko; Sugimura, Jun; Obara, Wataru; Sato, Toshiya; Takahashi, Mihoko; Chiba, Kenta; Abe, Tomiya

    2017-09-01

    An electrical or water supply and a blood purification machine are required for renal replacement therapy. There is a possibility that acute kidney injury can occur in large numbers and on a wide scale in the case of a massive earthquake, and there is the potential risk that the current supply will be unable to cope with acute kidney injury cases. However, non-machinery dialysis requires exclusive circuits and has the characteristic of not requiring the full-scale dialysis machines. We performed perfusion experiments that used non-machinery dialysis and recent blood purification machines in 30-min intervals, and the effectiveness of non-machinery dialysis was evaluated by the assessing the removal efficiency of potassium, which causes lethal arrhythmia during acute kidney injury. The non-machinery dialysis potassium removal rate was at the same level as continuous blood purification machines with a dialysate flow rate of 5 L/h after 15 min and continuous blood purification machines with a dialysate flow rate of 3 L/h after 30 min. Non-machinery dialysis required an exclusive dialysate circuit, the frequent need to replace bags, and new dialysate exchanged once every 30 min. However, it can be seen as an effective renal replacement therapy for crush-related acute kidney injury patients, even in locations or facilities not having the full-scale dialysis machines.

  1. μ CF Study of D/T and H/D/T Mixtures in Homogeneous and Inhomogeneous Medium, and Comparison of Their Fusion Yields

    Science.gov (United States)

    Eskandari, M. R.; Faghihi, F.; Gheisari, R.

    Muon reactivation coefficient are determined for muonic He (He = 42He = α , He = 23 He = h) for up to six (n = 1, 2, 3, ..., 6) states of formation and at temperature Tp = 100 eV and for various relative ion densities. In the next decade it may be possible to explore new conditions for further energy gain in muon catalyzed fusion system, μ CF, using nonuniform (temperature and density) plasma states. Here, we have considered a model for inhomogeneous μ CF for mixtures of D/T and H/D/T. Using coupled dynamical equations it is shown that the neutrons yield per muon injection, Yn (neutrons/muon), in the dt branch of an inhomogeneous H/D/T mixture is at least 2.24 times higher than similar homogeneous systems and this rate for a D/T mixture is 1.92. Also, we have compared the neutron yield in the dt branch of homogeneous D/T and H/D/T mixtures (temperature range T = 300-800 K, and density φ = 1 LHD). It is shown that Yn(D/T)/Yn(H/D/T) = 1.32, which is in good agreement with recently measured experimental values. In other words our calculations show that the addition of protonium to a D/T mixture leads to a significant decrease in the cycling rate for the physical conditions described herein.

  2. Acoustic Camera as a Fool for Identifying Machinery and Equipment Failures

    Directory of Open Access Journals (Sweden)

    Ľudmila Pavlikova

    2018-03-01

    Full Text Available Sound and noise are as old as humanity itself. They have accompanied civilization, evolution, and development for centuries. Music and speech represent not only the key elements of human life but also unpleasant feelings of noise that have always been an integral part of human existence. As industrial development has required more energy, powerful machinery, and equipment, there have been still noisier machines. Traffic has grown quickly due to the number and speed of vehicles. For that reason, an acoustic camera is used for the dynamic visualization of machinery and equipment noise as it analyses the sources of noise in details. Subsequently, qualified measures are introduced based on the results of the analysis. The paper considers launching another application. According to the proposed methodology, its use in identifying machinery and equipment failures and their maintenance is proved. The experiment was performed on a four-wheel lawn mower. The primary focus was on the identification of failures using an acoustic camera. The previous method allowed to quickly, precisely and efficiently identifying the failures in two out of five tested machines.

  3. Fission fragment simulation of fusion neutron radiation effects on bulk mechanical properties

    International Nuclear Information System (INIS)

    Van Konynenburg, R.A.; Mitchell, J.B.; Guinan, M.W.; Stuart, R.N.; Borg, R.J.

    1976-01-01

    This research demonstrates the feasibility of using homogeneously-generated fission fragments to simulate high-fluence fusion neutron damage in niobium tensile specimens. This technique makes it possible to measure radiation effects on bulk mechanical properties at high damage states, using conveniently short irradiation times. The primary knock-on spectrum for a fusion reactor is very similar to that produced by fission fragments, and nearly the same ratio of gas atoms to displaced atoms is produced in niobium. The damage from fission fragments is compared to that from fusion neutrons and fission reactor neutrons in terms of experimentally measured yield strength increase, transmission electron microscopy (TEM) observations, and calculated damage energies

  4. [Interest using 3D ultrasound and MRI fusion biopsy for prostate cancer detection].

    Science.gov (United States)

    Marien, A; De Castro Abreu, A; Gill, I; Villers, A; Ukimura, O

    2017-09-01

    The strategic therapy for prostate cancer depends on histo-pronostics data, which could be upgraded by obtaining targeted biopsies (TB) with MRI (magnetic resonance imagery) fusion 3D ultrasound. To compare diagnostic yield of image fusion guided prostate biopsy using image fusion of multi-parametric MRI (mpMRI) with 3D-TRUS. Between January 2010 and April 2013, 179 consecutive patients underwent outpatient TRUS biopsy using the real-time 3D TRUS tracking system (Urostation™). These patients underwent MRI-TRUS fusion targeted biopsies (TB) with 3D volume data of the MRI elastically fused with 3D TRUS at the time of biopsy. A hundred and seventy-three patients had TBs with fusion. Mean biopsy core per patient were 11.1 (6-14) for SB and 2.4 (1-6) for TB. SBs were positive in 11% compared to 56% for TB (Pperform the higher level of MR/US fusion and should be use for active surveillance. 4. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  5. Fluorescence excitation-emission matrix spectroscopy for degradation monitoring of machinery lubricants

    Science.gov (United States)

    Sosnovski, Oleg; Suresh, Pooja; Dudelzak, Alexander E.; Green, Benjamin

    2018-02-01

    Lubrication oil is a vital component of heavy rotating machinery defining the machine's health, operational safety and effectiveness. Recently, the focus has been on developing sensors that provide real-time/online monitoring of oil condition/lubricity. Industrial practices and standards for assessing oil condition involve various analytical methods. Most these techniques are unsuitable for online applications. The paper presents the results of studying degradation of antioxidant additives in machinery lubricants using Fluorescence Excitation-Emission Matrix (EEM) Spectroscopy and Machine Learning techniques. EEM Spectroscopy is capable of rapid and even standoff sensing; it is potentially applicable to real-time online monitoring.

  6. Safeness of radiological machinery

    International Nuclear Information System (INIS)

    Yokoyama, Shun

    1979-01-01

    The human factors affecting the safeness of radiological machinery, which are often very big and complicated machines, are described from the stand point of handling. 20 to 50% of the troubles on equipments seem to be caused by men. This percentage will become even higher in highly developed equipments. Human factors have a great influence on the safeness of radiological equipments. As the human factors, there are sensory factors and knowledge factors as well as psychological factors, and the combination of these factors causes mishandling and danger. Medical services at present are divided in various areas, and consist of the teamwork of the people in various professions. Good human relationship, education and control are highly required to secure the safeness. (Kobatake, H.)

  7. Economics and yields of energy plantations: Status and potential

    International Nuclear Information System (INIS)

    Kenney, W.A.; Gambles, R.L.; Zsuffa, L.

    1992-01-01

    A study was carried out to: determine the factors affecting the cost of energy conversion feedstocks in short rotation intensive culture plantations of trees; determine the factors influencing biomass yield; identify interrelationships between the previous two objectives; present estimates of potential biomass yields and associated economics; and to identify gaps in the knowledge of the economics and yields of biomass production and their interrelationships. Reported costs for most aspects had a wide range. Currently, yields of 10-15 dry Mg/hectare/y are readily achievable. Using the cost and yield data, and assuming a biomass price of $40/dry Mg, a series of cash flow analyses were performed. For the low cost inputs, all scenarios were marginally profitable. For the high cost inputs, none of the scenarios were profitable. A current scenario, using figures for contract farming, was not profitable, however this system would break even with a yield of 23.3 dry Mg/hectare/y, within the range of some production clones. A future scenario using farm labour with increased productivity, product values, and machinery efficiencies yielded a profit-making situation. The addition of incentives increased profitability. There is great potential for the production of woody biomass in Canada as a feedstock for energy and other products. Continued and more intensive breeding and selection to develop high yielding stress tolerant clones, cost efficient harvesting systems, continued research into optimization of planting density, rotation length and cultural techniques, and characterization of promising clones with respect to nutrient-use efficiency, site requirements and pest/disease resistance are important areas for further work. 81 refs., 3 figs., 13 tabs

  8. Welding technologies for nuclear machinery and equipment

    International Nuclear Information System (INIS)

    Kobayashi, Masahiro; Yokono, Tomomi.

    1991-01-01

    The main welding methods applied to nuclear machinery and equipment are shielded metal arc welding, submerged arc welding, MAG welding and TIG welding. But in the last 10 years, in order to improve the reliability required for the welding of nuclear machinery and equipment, the welding technologies aiming at the reduction of heat input, the decrease of the number of welding pass and the automatic control of welding factors have been applied for the main purpose of bettering the quality and excluding human errors. The merits and the technology of narrow gap, pulsed MAG welding and melt-through welding are explained. As the automation of TIG welding, image processing type narrow gap, hot wire TIG welding and remote control type automatic TIG welding are described. For the longitudinal welding of active metal sheet products, plasma key-hole welding is applied. Since the concentration of its arc is good, high speed welding with low heat input can be done. For the stainless steel cladding by welding, electroslag welding has become to be employed in place of conventional submerged arc welding. Arc is not generated in the electroslag welding, and the penetration into base metal is small. (K.I.)

  9. Rotating Machinery Predictive Maintenance Through Expert System

    Directory of Open Access Journals (Sweden)

    M. Sarath Kumar

    2000-01-01

    Full Text Available Modern rotating machines such as turbomachines, either produce or absorb huge amount of power. Some of the common applications are: steam turbine-generator and gas turbine-compressor-generator trains produce power and machines, such as pumps, centrifugal compressors, motors, generators, machine tool spindles, etc., are being used in industrial applications. Condition-based maintenance of rotating machinery is a common practice where the machine's condition is monitored constantly, so that timely maintenance can be done. Since modern machines are complex and the amount of data to be interpreted is huge, we need precise and fast methods in order to arrive at the best recommendations to prevent catastrophic failure and to prolong the life of the equipment. In the present work using vibration characteristics of a rotor-bearing system, the condition of a rotating machinery (electrical rotor is predicted using an off-line expert system. The analysis of the problem is carried out in an Object Oriented Programming (OOP framework using the finite element method. The expert system which is also developed in an OOP paradigm gives the type of the malfunctions, suggestions and recommendations. The system is implemented in C++.

  10. Fusion energy

    International Nuclear Information System (INIS)

    Gross, R.A.

    1984-01-01

    This textbook covers the physics and technology upon which future fusion power reactors will be based. It reviews the history of fusion, reaction physics, plasma physics, heating, and confinement. Descriptions of commercial plants and design concepts are included. Topics covered include: fusion reactions and fuel resources; reaction rates; ignition, and confinement; basic plasma directory; Tokamak confinement physics; fusion technology; STARFIRE: A commercial Tokamak fusion power plant. MARS: A tandem-mirror fusion power plant; and other fusion reactor concepts

  11. 46 CFR 35.25-1 - Examination of boilers and machinery by engineer-T/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Examination of boilers and machinery by engineer-T/ALL... Engine Department § 35.25-1 Examination of boilers and machinery by engineer—T/ALL. It shall be the duty of an engineer when assuming charge of the boilers to examine the same forthwith and thoroughly. If...

  12. Investigation of fusion proton and triton emission in ASDEX

    International Nuclear Information System (INIS)

    Leinberger, U.

    1991-01-01

    A diagnostic method of measuring the fusion rate profile was developed on ASDEX. The collimated protons and tritons from d-d fusion reaction are simultaneously detected by a semiconductor counter at a single position in the vacuum vessel for different viewing directions. The detection efficiency profiles for these viewing directions are numerically calculated from the measured currents in the coils and assumed plasma current distributions. Folding the detection efficiency profile with a fusion rate profile yields the proton and triton fluxes to the detector. Comparison with measured fluxes allows one to find a fusion rate profile in agreement with the experimental data. In certain cases the detection efficiency profile strongly on the plasma current density profile, and information on the current distribution in the plasma can thus be achieved. It was proved that the spectra from rotating plasmas are in accordance with the theory of a rotating thermal plasma. Deviations can only be found in the case of strong vignetting of the detection efficiency by structures in the vacuum vessel. (orig.)

  13. Osteoclast Fusion

    DEFF Research Database (Denmark)

    Marie Julie Møller, Anaïs; Delaissé, Jean-Marie; Søe, Kent

    2017-01-01

    on the nuclearity of fusion partners. While CD47 promotes cell fusions involving mono-nucleated pre-osteoclasts, syncytin-1 promotes fusion of two multi-nucleated osteoclasts, but also reduces the number of fusions between mono-nucleated pre-osteoclasts. Furthermore, CD47 seems to mediate fusion mostly through...... individual fusion events using time-lapse and antagonists of CD47 and syncytin-1. All time-lapse recordings have been studied by two independent observers. A total of 1808 fusion events were analyzed. The present study shows that CD47 and syncytin-1 have different roles in osteoclast fusion depending...... broad contact surfaces between the partners' cell membrane while syncytin-1 mediate fusion through phagocytic-cup like structure. J. Cell. Physiol. 9999: 1-8, 2016. © 2016 Wiley Periodicals, Inc....

  14. Machinery prognostics and prognosis oriented maintenance management

    CERN Document Server

    Yan, Jihong

    2014-01-01

    This book gives a complete presentatin of the basic essentials of machinery prognostics and prognosis oriented maintenance management, and takes a look at the cutting-edge discipline of intelligent failure prognosis technologies for condition-based maintenance.  Latest research results and application methods are introduced for signal processing, reliability moelling, deterioration evaluation, residual life prediction and maintenance-optimization as well as applications of these methods.

  15. Optimization Model for Machinery Selection of Multi-Crop Farms in Elsuki Agricultural Scheme

    Directory of Open Access Journals (Sweden)

    Mysara Ahmed Mohamed

    2017-07-01

    Full Text Available The optimization machinery model was developed to aid decision-makers and farm machinery managers in determining the optimal number of tractors, scheduling the agricultural operation and minimizing machinery total costs. For purpose of model verification, validation and application input data was collected from primary & secondary sources from Elsuki agricultural scheme for two seasons namely 2011-2012 and 2013-2014. Model verification was made by comparing the numbers of tractors of Elsuki agricultural scheme for season 2011-2012 with those estimated by the model. The model succeeded in reducing the number of tractors and operation total cost by 23%. The effect of optimization model on elements of direct cost saving indicated that the highest cost saving is reached with depreciation, repair and maintenance (23% and the minimum cost saving is attained with fuel cost (22%. Sensitivity analysis in terms of change in model input for each of cultivated area and total costs of operations showing that: Increasing the operation total cost by 10% decreased the total number of tractors after optimization by 23% and total cost of operations was also decreased by 23%. Increasing the cultivated area by 10%, decreased the total number of tractors after optimization by(12% and total cost of operations was also decreased by 12% (16669206 SDG(1111280 $ to 14636376 SDG(975758 $. For the case of multiple input effect of the area and operation total cost resulted in decrease maximum number of tractors by 12%, and the total cost of operations also decreased by 12%. It is recommended to apply the optimization model as pre-requisite for improving machinery management during implementation of machinery scheduling.

  16. Machinery for Forest Chip Production in Finland in 2007 and in the Future

    Energy Technology Data Exchange (ETDEWEB)

    Kaerhae, Kalle (Metsaeteho Oy, P.O. Box 101, FI-00171 Helsinki (Finland))

    2008-10-15

    Metsaeteho Oy's study consisted of a survey of the production machinery for forest chips used by energy plants in 2007. The major forest chip suppliers in Finland were involved in the study. In addition, the machinery and equipment stocked by the manufacturers and vendors of energy wood harvester heads, stump lifting devices, and chippers were also surveyed. The study provided also an estimate of future machinery requirements for forest chip production in Finland. The study estimated that a total of 1,100 machine and truck units were employed in the production of forest chips for energy plants in 2007. A total of 770 machine and truck units were contracted for the major forest chip suppliers in 2007. Increasing forest chip consumption will considerable increase the demand for additional forest chip production resources in the future. If the consumption of forest chips by energy plants in 2015 reaches 15 TWh, i.e. about 7.5 mill. m3, then the forest machine and truck requirement will be over 1,700 units. The corresponding machinery requirement at an energy plant with a forest chip consumption of 25 TWh (approx. 12.5 mill. m3), will be close to 2,300 machine and truck units

  17. Power electronics and electric machinery challenges and opportunities in electric and hybrid vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Adams, D.J.; Hsu, J.S.; Young, R.W. [Oak Ridge National Lab., TN (United States); Peng, F.Z. [Univ. of Tennessee, Knoxville, TN (United States)

    1997-06-01

    The development of power electronics and electric machinery presents significant challenges to the advancement of electric and hybrid vehicles. Electronic components and systems development for vehicle applications have progressed from the replacement of mechanical systems to the availability of features that can only be realized through interacting electronic controls and devices. Near-term applications of power electronics in vehicles will enable integrated powertrain controls, integrated chassis system controls, and navigation and communications systems. Future applications of optimized electric machinery will enable highly efficient and lightweight systems. This paper will explore the areas where research and development is required to ensure the continued development of power electronics and electric machines to meet the rigorous demands of automotive applications. Additionally, recent advances in automotive related power electronics and electric machinery at Oak Ridge National Laboratory will be explained. 3 refs., 5 figs.

  18. The experimental study on efficiency improvement of turbo machinery supported with magnetic bearings

    International Nuclear Information System (INIS)

    Park, In Hwang; Park, Young Ho; Han, Dong Chul

    2007-01-01

    To implement a conventional electromagnetic bearing in small turbo machinery, it has problems such as load capacity and size. Therefore, in this paper, these problems are resolved by using a permanent magnet biased electromagnetic bearing as a thrust bearing of small turbo machinery. Because the flux path of the bearing is designed by reluctance path modulation using an electromagnet and a permanent magnet, the bearing improves upon non-linearity, power consumption, size and load capacity of a conventional electromagnetic bearing. Test rotating the shaft over 500,000DN were carried out to verify the performance of the proposed small turbo machinery. In addition, the relationships between mass flow rate and pressure rise were measured as changing the tip clearance to verify the feasibility of efficiency improvement and active surge control and these results were compared with theoretical results

  19. Estimation of the {alpha} particles and neutron distribution generated during a fusion reaction; Evaluation de la distribution des particules {alpha} et des neutrons issus de la reaction de fusion

    Energy Technology Data Exchange (ETDEWEB)

    Dellacherie, S.

    1997-12-01

    The respective distributions (or density probabilities) of {alpha} particles and neutrons have been modeled using a Monte-Carlo method for the thermonuclear fusion reaction D + T {yields} {alpha} + n + 17.6 MeV. (N.T.).

  20. Fluid machinery application, selection, and design

    CERN Document Server

    Wright, Terry

    2013-01-01

    Published nearly a decade ago, Fluid Machinery: Performance, Analysis, and Design quickly became popular with students, professors, and professionals because of its comprehensive and comprehensible introduction to the fluid mechanics of turbomachinery. Renamed to reflect its wider scope and reorganized content, this second edition provides a more logical flow of information that will enhance understanding. In particular, it presents a consistent notation within and across chapters, updating material when appropriate. Although the authors do account for the astounding growth in the field of com

  1. Fusion

    CERN Document Server

    Mahaffey, James A

    2012-01-01

    As energy problems of the world grow, work toward fusion power continues at a greater pace than ever before. The topic of fusion is one that is often met with the most recognition and interest in the nuclear power arena. Written in clear and jargon-free prose, Fusion explores the big bang of creation to the blackout death of worn-out stars. A brief history of fusion research, beginning with the first tentative theories in the early 20th century, is also discussed, as well as the race for fusion power. This brand-new, full-color resource examines the various programs currently being funded or p

  2. The kinematics of machinery outlines of a theory of machines

    CERN Document Server

    Reuleaux, Franz

    2012-01-01

    A classic on the kinematics of machinery, this volume was written by the Father of Kinematics. Reuleaux writes with authority and precision, developing the subject from its fundamentals. 450 figures. 1876 edition.

  3. A comparison of microstructures in copper irradiated with fission, fusion, and spallation neutrons

    International Nuclear Information System (INIS)

    Muroga, T.; Heinisch, H.L.; Sommer, W.F.; Ferguson, P.D.

    1992-01-01

    The objective of this work is to investigate the effects of the neutron energy spectrum in low dose irradiations on the microstructure and mechanical properties of metals. The microstructures of pure copper irradiated to low doses at 36-90 C with spallation neutrons, fusion neutrons and fission neutrons are compared. The defect cluster densities for the spallation and fusion neutrons are very similar when compared on the basis of displacements per atom (dpa). In both cases, the density increases in proportion to the square root of the dpa. The difference in defect density between fusion neutrons and fission neutrons corresponds with differences observed in data on yield stress changes

  4. Conservation of fusion reaction optimum yield in focused discharges with variable voltage and energy but constant geometry

    International Nuclear Information System (INIS)

    Bilbao, L.; Bortolotti, A.; Brzosko, J.; DeChiara, P.; Kilic, H.; Mezzetti, F.; Nardi, V.; Powell, C.; Wang, J.

    1992-01-01

    The D-D fusion reaction yield per pulse, Y n , of focused discharges is monitored by changing the capacitor bank voltage Vo by a factor 2 without any change of construction parameters and of the filling gas pressure of two plasma focus machines PF1 (C1 congruent 50 microfarad, L1 congruent 20 nanohenry) and PF2 (C2 = 1.2Cl, L2 = 2L1). The interval Δ = 1 ± (ΔW)/W of the capacitor bank energy values W on which the scaling Y n ∼ W 2 applies is greater for PF2, where the corresponding variation ΔI2 of the peak electrode current I2 is smaller (in agreement with Lw/C2 > L1/C1) than for PF1. Suitable figure of merit (in terms of ΔI, ΔW, L, C, etc.) are used for determining the relative importance of (i), the induced variations of the pinch fine structure and of (ii), the variations of the insulator surface at the PF breech, with bearing on the initial stage of the current sheath formation. Schlieren and magnetic probe data monitor the current sheath structure and propagation speed. The D + ion emission from the pinch is monitored in the energy interval 50 keV to 25 MeV for clarifying the links between the pinch fine structure and the set of leading macroscopic parameters of the PF discharges

  5. The Design of High Reliability Magnetic Bearing Systems for Helium Cooled Reactor Machinery

    International Nuclear Information System (INIS)

    Swann, M.; Davies, N.; Jayawant, R.; Leung, R.; Shultz, R.; Gao, R.; Guo, Z.

    2014-01-01

    The requirements for magnetic bearing equipped machinery used in high temperature, helium cooled, graphite moderated reactor applications present a set of design considerations that are unlike most other applications of magnetic bearing technology in large industrial rotating equipment, for example as used in the oil and gas or other power generation applications. In particular, the bearings are typically immersed directly in the process gas in order to take advantage of the design simplicity that comes about from the elimination of ancillary lubrication and cooling systems for bearings and seals. Such duty means that the bearings will usually see high temperatures and pressures in service and will also typically be subject to graphite particulate and attendant radioactive contamination over time. In addition, unlike most industrial applications, seismic loading events become of paramount importance for the magnetic bearings system, both for actuators and controls. The auxiliary bearing design requirements, in particular, become especially demanding when one considers that the whole mechanical structure of the magnetic bearing system is located inside an inaccessible pressure vessel that should be rarely, if ever, disassembled over the service life of the power plant. Lastly, many machinery designs for gas cooled nuclear power plants utilize vertical orientation. This circumstance presents its own unique requirements for the machinery dynamics and bearing loads. Based on the authors’ experience with machine design and supply on several helium cooled reactor projects including Ft. St. Vrain (US), GT-MHR (Russia), PBMR (South Africa), GTHTR (Japan), and most recently HTR-PM (China), this paper addresses many of the design considerations for such machinery and how the application of magnetic bearings directly affects machinery reliability and availability, operability, and maintainability. Remote inspection and diagnostics are a key focus of this paper. (author)

  6. Near and sub-barrier fusion studies with radioactive nuclei: an overview

    International Nuclear Information System (INIS)

    Majumdar, Harashit

    2004-01-01

    Full text: Understanding of the reaction mechanism with radioactive nuclei, e.g., halo nuclei, at near barrier energies appears to be a challenging problem at present. Recent experimental and theoretical investigations of fusion of exotic nuclei with stable targets have yielded new insights into the structure of these nuclei and its effects on the fusion reaction dynamics. One interesting and intriguing result of this type of study is the controversy over fusion enhancement in the presence of strong break-up channels. Other novel information include an increase of break-up cross-sections and weakening or absence of threshold anomaly, related to energy dependence of optical model potentials, in the neighbourhood of the barrier. It is believed that the coupling of the entrance channel to different non-elastic channels (including break-up) is responsible for the above phenomena and these aspects are more prominent in the near barrier region. An overview of the experimental studies of fusion excitation function with RIB will be presented

  7. Near and sub-barrier fusion studies with radioactive nuclei: an overview

    International Nuclear Information System (INIS)

    Majumdar, Harashit

    2004-01-01

    Full Text: Understanding of the reaction mechanism with radioactive nuclei, e.g., halo nuclei, at near barrier energies appears to be a challenging problem at present. Recent experimental and theoretical investigations of fusion of exotic nuclei with stable targets have yielded new insights into the structure of these nuclei and its effects on the fusion reaction dynamics. One interesting and intriguing result of this type of study is the controversy over fusion enhancement in the presence of strong break-up channels. Other novel information include an increase of break-up cross-sections and weakening or absence of threshold anomaly, related to energy dependence of optical model potentials, in the neighbourhood of the barrier. It is believed that the coupling of the entrance channel to different non-elastic channels (including break-up) is responsible for the above phenomena and these aspects are more prominent in the near barrier region. An overview of the experimental studies of fusion excitation function with RIB will be presented

  8. Muon nuclear fusion and low temperature nuclear fusion

    International Nuclear Information System (INIS)

    Nagamine, Kanetada

    1990-01-01

    Low temperature (or normal temperature) nuclear fusion is one of the phenomena causing nuclear fusion without requiring high temperature. In thermal nuclear fusion, the Coulomb barrier is overcome with the help of thermal energy, but in the low temperature nuclear fusion, the Coulomb barrier is neutralized by the introduction of the particles having larger mass than electrons and negative charges, at this time, if two nuclei can approach to the distance of 10 -13 cm in the neutral state, the occurrence of nuclear fusion reaction is expected. As the mass of the particles is heavier, the neutral region is smaller, and nuclear fusion is easy to occur. The particles to meet this purpose are the electrons within substances and muons. The research on muon nuclear fusion became suddenly active in the latter half of 1970s, the cause of which was the discovery of the fact that the formation of muons occurs resonantly rapidly in D-T and D-D systems. Muons are the unstable elementary particles having the life of 2.2 μs, and they can have positive and negative charges. In the muon catalyzed fusion, the muons with negative charge take part. The principle of the muon catalyzed fusion, its present status and future perspective, and the present status of low temperature nuclear fusion are reported. (K.I.)

  9. Managing the exploitation life of the mining machinery for an unlimited duration of time

    Directory of Open Access Journals (Sweden)

    Vujić Slobodan

    2011-01-01

    Full Text Available The problem of determining the optimum exploitation life of machinery, namely, the optimum time for machinery and equipment replacement, represents a complex and highly responsible engineering task. Taking into consideration the situation prevailing at coal pit mines in Serbia, the tasks of this rank are very complex and difficult. To make a decision on the replacement of capital equipment and machinery, such as bucket wheel excavators within the mentioned systems, implies a management task of utmost responsibility. It requires high professional and analytical knowledge as well as reliable arguments, based on a multidisciplinary professional approach. In this paper, the authors present their views on the problem of establishing the optimum exploitation life of bucket wheel excavators, offering an algorithm, based on dynamic programming, as a solution.

  10. Noise test system of rotating machinery in nuclear power station based on microphone array

    Science.gov (United States)

    Chang, Xincai; Guan, Jishi; Qi, Liangcai

    2017-12-01

    Rotating machinery plays an important role in all walks of life. Once the equipment fails, equipment maintenance and shutdown will cause great social harm and economic losses. Equipment safety operations at nuclear power stations have always been of top priority. It is prone to noise when the equipment is out of order or aging. Failure to find or develop equipment at the initial stage of equipment failure or ageing will pose a serious threat to the safety of the plant’s equipment. In this paper, sound imaging diagnosis technology is applied as a supplementary method to the condition monitoring and diagnosis system of rotating machinery in nuclear power stations. It provides a powerful guarantee for the condition monitoring and fault diagnosis of rotating machinery in nuclear power stations.

  11. Present Situation and Activities of ISO 14000 series in Heavy Machinery Industries; Jukikai meka no taiou jokyo

    Energy Technology Data Exchange (ETDEWEB)

    Tomisawa, Yukio. [Ishikawajima-Harima Heavy Industries Corp., Tokyo (Japan). Research Institute

    1999-01-15

    This paper shows the outline of the present situation and activities of ISO14000 series, environmental management system in heavy machinery industries. Today, main heavy machinery industries have already certified to ISO 14001 until this summer. The aim of the introduction of ISO 14001 are to establish the system improvement continuously by PDCA, to have essential elements in international trade and to keep up with the risk management. Some example of conducted ISO 14001 in heavy machinery industries are shown. The trend of heavy machinery industries will be able to predict to three key words, internationalization, network and opening information. The new role expected to environmental material engineer are indicated to research and develop ecomaterial by using LCA and to support the recycling, waste treatment and other technical basis of the environmental management system. (author)

  12. Intense light-ion beams provide a robust, common-driver path toward ignition, gain, and commercial fusion energy

    International Nuclear Information System (INIS)

    Ramirez, J.J.; Cook, D.L.

    1993-01-01

    Intense light-ion beams are being developed for investigations of inertial confinement fusion (ICF). This effort has concentrated on developing the Particle Beam Fusion Accelerator II (PBFA II) at Sandia as a driver for ICF target experiments, on design concepts for a high-yield, high-gain Laboratory Microfusion Facility (LMF), and on a comprehensive system study of a light-ion beam-driven commercial fusion reactor (LIBRA). Reports are given on the status of design concepts and research in these areas. (author)

  13. Contributions of the National Ignition Facility to the development of Inertial Fusion Energy

    International Nuclear Information System (INIS)

    Tobin, M.; Logan, G.; Diaz De La Rubia, T.; Schrock, V.; Schultz, K.; Tokheim, R.; Abdou, M.; Bangerter, R.

    1994-06-01

    The Department of Energy is proposing to construct the National Ignition Facility (NIF) to embark on a program to achieve ignition and modest gain in the laboratory early in the next century. The NIF will use a ≥ 1.8-MJ, 0.35-mm laser with 192 independent beams, a fifty-fold increase over the energy of the Nova laser. System performance analyses suggest yields as great as 20 MJ may be achievable. The benefits of a micro-fusion capability in the laboratory include: essential contributions to defense programs, resolution of important Inertial Fusion Energy issues, and unparalleled conditions of energy density for basic science and technology research. We have begun to consider the role the National Ignition Facility will fill in the development of Inertial Fusion Energy. While the achievement of ignition and gain speaks for itself in terms of its impact on developing IFE, we believe there are areas of IFE development such as fusion power technology, IFE target design and fabrication, and understanding chamber dynamics, that would significantly benefit from NIF experiments. In the area of IFE target physics, ion targets will be designed using the NIF laser, and feasibility of high gain targets will be confirmed. Target chamber dynamics experiments will benefit from x-ray and debris energies that mimic in-IFE-chamber conditions. Fusion power technology will benefit from using single-shot neutron yields to measure spatial distribution of neutron heating, activation, and tritium breeding in relevant materials. IFE target systems will benefit from evaluating low-cost target fabrication techniques by testing such targets on NIF. Additionally, we believe it is feasible to inject up to four targets and engage them with the NIF laser by triggering the beams in groups of ∼50 separated in time by ∼0.1 s. Sub-ignition neutron yields would allow an indication of symmetry achieved in such proof-of-principle rep-rate experiments

  14. Explosion hazard in liquid nitrogen cooled fusion systems

    International Nuclear Information System (INIS)

    Brereton, S.J.

    1988-01-01

    The explosion hazard associated with the use of liquid nitrogen in a radiation environment in fusion facilities has been investigated. The principal product of irradiating liquid nitrogen is thought to be ozone, resulting from the action of radiation on oxygen impurity. Ozone is a very unstable material, and explosions may occur as it rapidly decomposes to oxygen. Occurrences of this problem in irradiated liquid nitrogen systems are reviewed. An empirical expression, from early experiments, for the yield of ozone in liquid nitrogen-oxygen mixtures exposed to gamma radiation is employed to assess the degree of ozone explosion hazard expected at fusion facilities. The problem is investigated for the Compact Ignition Tokamak (CIT) as a particular example. 16 refs., 5 figs., 1 tab

  15. Exploring a unique vision for heavy ion fusion

    Energy Technology Data Exchange (ETDEWEB)

    LOGAN, B.G.; Logan, B.G.

    2007-08-06

    A quest for more efficient beam-to-fuel energy coupling via polar direct drive (30% overall), to enable: (1) Self-T-breeding, self-neutron-energy-absorbing, large {pi}r, T-Lean targets {at} < 4 MJ driver energies; (2) Efficient fusion energy coupling into plasma for direct MHD conversion with moderate yields < 1 GJ; (3) Balance-of-plant costs 10X lower than steam cycle (e.g., < 80 $/kWe instead of 800 $/kWe); (4) CoE low enough (<3 cts/kWehr) for affordable water and H{sub 2} fuel for 10 B people on a hot planet; and (5) Enough fissile fuel production for 38 LWR's per GW{sub fusion} if uranium gets too expensive meantime.

  16. Fusion reactor start-up without an external tritium source

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, S., E-mail: Shanliang.Zheng@ccfe.ac.uk; King, D.B.; Garzotti, L.; Surrey, E.; Todd, T.N.

    2016-02-15

    Highlights: • Investigated the feasibility (including plasma physics, neutronics and economics) of starting a fusion reactor from running pure D–D fusion reactor to gradually move towards the D–T operation. • Proposed building up tritium from making use of neutrons generated by D–D fusion reactions. • Studied plasma physics feasibility for pure D–D operation and provided consistent fusion power and neutron yield in the plasma with different mixture of deuterium and tritium. • Discussed the economics aspect for operating a pure D–D fusion reactor towards a full-power D–T fusion reactor. - Abstract: It has long been recognised that the shortage of external tritium sources for fusion reactors using D–T, the most promising fusion fuel, requires all such fusion power plants (FPP) to breed their own tritium. It is also recognised that the initial start-up of a fusion reactor will require several kilograms of tritium within a scenario in which radioactive decay, ITER and subsequent demonstrator reactors are expected to have consumed most of the known tritium stockpile. To circumvent this tritium fuel shortage and ultimately achieve steady-state operation for a FPP, it is essential to first accumulate sufficient tritium to compensate for loss due to decay and significant retention in the materials in order to start a new FPP. In this work, we propose to accumulate tritium starting from D–D fusion reactions, since D exists naturally in water, and to gradually build up the D–T plasma targeted in fusion reactor designs. There are two likely D–D fusion reaction channels, (1) D + D → T + p, and (2) D + D → He3 + n. The tritium can be generated via the reaction channel ‘(1)’ and the 2.45 MeV neutrons from ‘(2)’ react with lithium-6 in the breeding blanket to produce more tritium to be fed back into plasma fuel. Quantitative evaluations are conducted for two blanket concepts to assess the feasibility and suitability of this approach to FPP

  17. Progress in heavy-ion drivers for inertial fusion

    International Nuclear Information System (INIS)

    Friedman, A.; Bangerter, R.O.; Herrmannsfeldt, W.B.

    1994-01-01

    Heavy-ion induction accelerators are being developed as fusion drivers for ICF power production in the US Inertial Fusion Energy (IFE) program, in the Office of Fusion Energy of the US Department of Energy. In addition, they represent an attractive driver option for a high-yield microfusion facility for defense research. This paper describes recent progress in induction drivers for Heavy-Ion Fusion (HIF), and plans for future work. It presents research aimed at developing drivers having reduced cost and size, specifically advanced induction linacs and recirculating induction accelerators (recirculators). The goals and design of the Elise accelerator being built at Lawrence Berkeley Laboratory (LBL), as the first stage of the ILSE (Induction Linac Systems Experiments) program, are described. Elise will accelerate, for the first time, space-charge-dominated ion beams which are of full driver scale in line-charge density and diameter. Elise will be a platform on which the critical beam manipulations of the induction approach can be explored. An experimental program at Lawrence Livermore National Laboratory (LLNL) exploring the recirculator principle on a small scale is described in some detail; it is expected that these studies will result ultimately in an operational prototype recirculating induction accelerator. In addition, other elements of the US HIF program are described

  18. Fusion technology: The Iter fusion experiment

    International Nuclear Information System (INIS)

    Dietz, K.J.

    1994-01-01

    Plans for the Iter international fusion experiment, in which the European Union, Japan, Canada, Russia, Sweden, Switzerland, and the USA cooperate, were begun in 1985, and construction work started in early 1994. These activities serve for the preparation of the design and construction documents for a research reactor in which a stable fusion plasma is to be generated. This is to be the basis for the construction of a fusion reactor for electricity generation. Preparatory work was performed in the Tokamak experiments with JET and TFTR. The fusion power of 1.5 GW will be attained, thus enabling Iter to keep a deuterium-tritium plasma burning. (orig.) [de

  19. A phycocyanin·phellandrene synthase fusion enhances recombinant protein expression and β-phellandrene (monoterpene) hydrocarbons production in Synechocystis (cyanobacteria).

    Science.gov (United States)

    Formighieri, Cinzia; Melis, Anastasios

    2015-11-01

    Cyanobacteria can be exploited as photosynthetic platforms for heterologous generation of terpene hydrocarbons with industrial applications. Transformation of Synechocystis and heterologous expression of the β-phellandrene synthase (PHLS) gene alone is necessary and sufficient to confer to Synechocystis the ability to divert intermediate terpenoid metabolites and to generate the monoterpene β-phellandrene during photosynthesis. However, terpene synthases, including the PHLS, have a slow Kcat (low Vmax) necessitating high levels of enzyme concentration to enable meaningful rates and yield of product formation. Here, a novel approach was applied to increase the PHLS protein expression alleviating limitations in the rate and yield of β-phellandrene product generation. Different PHLS fusion constructs were generated with the Synechocystis endogenous cpcB sequence, encoding for the abundant in cyanobacteria phycocyanin β-subunit, expressed under the native cpc operon promoter. In one of these constructs, the CpcB·PHLS fusion protein accumulated to levels approaching 20% of the total cellular protein, i.e., substantially higher than expressing the PHLS protein alone under the same endogenous cpc promoter. The CpcB·PHLS fusion protein retained the activity of the PHLS enzyme and catalyzed β-phellandrene synthesis, yielding an average of 3.2 mg product g(-1) dry cell weight (dcw) versus the 0.03 mg g(-1)dcw measured with low-expressing constructs, i.e., a 100-fold yield improvement. In conclusion, the terpene synthase fusion-protein approach is promising, as, in this case, it substantially increased the amount of the PHLS in cyanobacteria, and commensurately improved rates and yield of β-phellandrene hydrocarbons production in these photosynthetic microorganisms. Copyright © 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

  20. Fusion Physics

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Mitsuru; Lackner, Karl; Tran, Minh Quang [eds.

    2012-09-15

    Recreating the energy production process of the Sun - nuclear fusion - on Earth in a controlled fashion is one of the greatest challenges of this century. If achieved at affordable costs, energy supply security would be greatly enhanced and environmental degradation from fossil fuels greatly diminished. Fusion Physics describes the last fifty years or so of physics and research in innovative technologies to achieve controlled thermonuclear fusion for energy production. The International Atomic Energy Agency (IAEA) has been involved since its establishment in 1957 in fusion research. It has been the driving force behind the biennial conferences on Plasma Physics and Controlled Thermonuclear Fusion, today known as the Fusion Energy Conference. Hosted by several Member States, this biennial conference provides a global forum for exchange of the latest achievements in fusion research against the backdrop of the requirements for a net energy producing fusion device and, eventually, a fusion power plant. The scientific and technological knowledge compiled during this series of conferences, as well as by the IAEA Nuclear Fusion journal, is immense and will surely continue to grow in the future. It has led to the establishment of the International Thermonuclear Experimental Reactor (ITER), which represents the biggest experiment in energy production ever envisaged by humankind.

  1. Information Fusion for Natural and Man-Made Disasters

    Science.gov (United States)

    2007-01-31

    2002. 27. J. Llinas, E. Hansen, Updates, Issues and Questions, Third Workshop on Critical Issues in Information Fusion, Java Center N.Y., September... angular trajectory, shape, size), etc. Many of the other relations, however, are not so easily processed, since they involve complex relational...knowledge combination to treat the uncertainty in the- uncertainty 3. Logic/Symbolic: rules or scripts to yield track confidences based upon the each

  2. A Modelling Approach to Multibody Dynamics of Fluid Power Machinery with Hydrodynamic Lubrication

    DEFF Research Database (Denmark)

    Johansen, Per; Rømer, Daniel; Andersen, Torben Ole

    2013-01-01

    The efficiency potential of the digital displacement technology and the increasing interest in hydraulic transmissions in wind and wave energy applications has created an incentive for development of high efficiency fluid power machinery. Modelling and analysis of fluid power machinery loss...... mechanisms is necessary in order to accommodate this demand. At present fully coupled thermo-elastic models for various tribological interfaces has been presented. However, in order to analyse the interaction between tribological interfaces in fluid power pumps and motors, these interface models needs...

  3. Rotating machinery surveillance system reduces plant downtime and radiation exposure

    International Nuclear Information System (INIS)

    Bohanick, J.S.; Robinson, J.C.; Allen, J.W.

    1988-01-01

    A rotating machinery surveillance system (RMSS) was permanently installed at Grand Gulf nuclear station (GGNS) as part of a program sponsored by the US Department of Energy whose goal was to reduce radiation exposure to power plant personnel resulting from the inspection, maintenance, and repair of rotating machinery. The RMSS was installed at GGNS in 1983 to continuously monitor 173 analog vibration signals from proximity probes mounted on 26 machine trains and ∼450 process data points via a computer data link. Vibration frequency spectra, i.e., the vibration amplitude versus frequency of vibration, and various characterizations of these spectra are the fundamental data collected by the RMSS for performing machinery diagnostics. The RMSS collects vibration frequency spectra on a daily basis for all the monitored rotating equipment and automatically stores the collected spectra for review by the vibration engineer. Vibration spectra automatically stored by the RMSS fall into categories that include the last normal, alarm, minimum and maximum, past three-day data set, baseline, current, and user-saved spectra. During first and second fuel-cycle operation at GGNS, several significant vibration problems were detected by the RMSS. Two of these are presented in this paper: recirculation pumps and turbine-generator bearing degradation. The total reduction in personnel radiation exposure at GGNS from 1985 to 1987 due to the presence of the RMSS was estimated to be in the range from 49 to 54 person-rem

  4. Direct energy conversion for IEC fusion for space applications

    International Nuclear Information System (INIS)

    Momota, Hiromu; Nadler, Jon; Miley, George H.

    2000-08-01

    The paper describes a concept of extracting fusion power from D- 3 He fueled IEC (Inertia Electrostatic Configuration) devices. The fusion system consists of a series of fusion modules and direct energy converters at an end or at both ends. This system of multiple units is linear and is connected by a magnetic field. A pair of coils anti-parallel to the magnetic field yields a field-null domain at the center of each unit as required for IEC operation. A stabilizing coil installed between the coil pairs eliminates the strong attractive force between the anti-parallel coils. Accessible regions for charged particle trajectories are essentially isolated from the coil structure. Thus, charged particles are directed along magnetic field lines to the direct energy converter without appreciable losses. A direct energy converter unit designed to be compatible to this unique system is also described. It basically consists of a separator and a traveling wave converter. A separator separates low energy ions and electron from the 14.7 MeV fusion protons and then converts their energy into electricity. In the traveling wave direct energy converter, fusion protons are modulated to form bunches. It couples with a transmission line to couple AC power out. The overall conversion efficiency of this system, combined with E- 3 He IEC cores, is estimated as high as 60%. (author)

  5. Direct energy conversion for IEC fusion for space applications

    Energy Technology Data Exchange (ETDEWEB)

    Momota, Hiromu; Nadler, Jon [National Inst. for Fusion Science, Toki, Gifu (Japan); Miley, George H. [Fusion Studies Laboratory, Urbana, IL (United States)

    2000-08-01

    The paper describes a concept of extracting fusion power from D-{sup 3}He fueled IEC (Inertia Electrostatic Configuration) devices. The fusion system consists of a series of fusion modules and direct energy converters at an end or at both ends. This system of multiple units is linear and is connected by a magnetic field. A pair of coils anti-parallel to the magnetic field yields a field-null domain at the center of each unit as required for IEC operation. A stabilizing coil installed between the coil pairs eliminates the strong attractive force between the anti-parallel coils. Accessible regions for charged particle trajectories are essentially isolated from the coil structure. Thus, charged particles are directed along magnetic field lines to the direct energy converter without appreciable losses. A direct energy converter unit designed to be compatible to this unique system is also described. It basically consists of a separator and a traveling wave converter. A separator separates low energy ions and electron from the 14.7 MeV fusion protons and then converts their energy into electricity. In the traveling wave direct energy converter, fusion protons are modulated to form bunches. It couples with a transmission line to couple AC power out. The overall conversion efficiency of this system, combined with E-{sup 3}He IEC cores, is estimated as high as 60%. (author)

  6. EMP Fusion

    OpenAIRE

    KUNTAY, Isık

    2010-01-01

    This paper introduces a novel fusion scheme, called EMP Fusion, which has the promise of achieving breakeven and realizing commercial fusion power. The method is based on harnessing the power of an electromagnetic pulse generated by the now well-developed flux compression technology. The electromagnetic pulse acts as a means of both heating up the plasma and confining the plasma, eliminating intermediate steps. The EMP Fusion device is simpler compared to other fusion devices and this reduces...

  7. First wall studies of a laser-fusion hybrid reactor design

    International Nuclear Information System (INIS)

    Hovingh, J.

    1976-09-01

    The design of a first wall for a 20 MW thermonuclear power laser fusion hybrid reactor is presented. The 20 mm thick graphite first wall is located 3.5 m from the DT microexplosion with a thermonuclear yield of 10 MJ. Estimates of the energy deposition, temperature, stresses, and material vaporized from the first wall due to the interaction of the x-rays, charged particle debris, and reflected laser light with the graphite are presented, along with a brief description of the analytical methods used for these estimations. Graphite is a viable first wall material for inertially-confined fusion reactors, with lifetimes of a year possible

  8. Cold fusion valleys for the synthesis of Z=118 isotopes

    International Nuclear Information System (INIS)

    Gherghescu, R.

    2005-01-01

    Cold fusion reactions are investigated with the goal to synthesize Z=118 isotopes with neutron numbers N=162, 168, 172, 176. Potential energy surfaces are calculated as the result of dynamic minimization with independent deformations of the target and projectile, small semi-axis of the projectile and distance between centers as degrees of freedom. An advanced binary macroscopic-microscopic method is used to obtain the deformation energy and the Werner-Wheeler approximation yield the mass tensor. Charge asymmetry is varied for the same mass asymmetry channel which belongs to a given energy valley. The highest penetrability values are obtained for cold fusion channels with Sn, Te and Xe isotopes as projectiles

  9. 46 CFR 182.460 - Ventilation of spaces containing machinery powered by, or fuel tanks for, gasoline.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Ventilation of spaces containing machinery powered by, or fuel tanks for, gasoline. 182.460 Section 182.460 Shipping COAST GUARD, DEPARTMENT OF HOMELAND..., gasoline. (a) A space containing machinery powered by, or fuel tanks for, gasoline must have a ventilation...

  10. International bulletin on atomic and molecular data for fusion. No.2

    International Nuclear Information System (INIS)

    Beaty, E.C.; Katsonis, K.

    1977-10-01

    This bulletin deals with atomic and molecular data for fusion (spectroscopic data, atomic and molecular collisions, surface effects, ...). Particular emphasis is given to data applicable to Tokamak devices. A bibliography for the most recent data presented in the document is provided. A description of work in progress and ''Data Requests'' in the fusion field are also mentioned. Numerical data on light ion sputtering yields of first wall materials, electron capture and impact ionization for iron ions colliding with molecular hydrogen and charge exchange between multicharged ions and helium, argon, and, atomic or molecular hydrogen are given

  11. Multiple Cylinder Free-Piston Stirling Machinery

    Science.gov (United States)

    Berchowitz, David M.; Kwon, Yong-Rak

    In order to improve the specific power of piston-cylinder type machinery, there is a point in capacity or power where an advantage accrues with increasing number of piston-cylinder assemblies. In the case of Stirling machinery where primary energy is transferred across the casing wall of the machine, this consideration is even more important. This is due primarily to the difference in scaling of basic power and the required heat transfer. Heat transfer is found to be progressively limited as the size of the machine increases. Multiple cylinder machines tend to preserve the surface area to volume ratio at more favorable levels. In addition, the spring effect of the working gas in the so-called alpha configuration is often sufficient to provide a high frequency resonance point that improves the specific power. There are a number of possible multiple cylinder configurations. The simplest is an opposed pair of piston-displacer machines (beta configuration). A three-cylinder machine requires stepped pistons to obtain proper volume phase relationships. Four to six cylinder configurations are also possible. A small demonstrator inline four cylinder alpha machine has been built to demonstrate both cooling operation and power generation. Data from this machine verifies theoretical expectations and is used to extrapolate the performance of future machines. Vibration levels are discussed and it is argued that some multiple cylinder machines have no linear component to the casing vibration but may have a nutating couple. Example applications are discussed ranging from general purpose coolers, computer cooling, exhaust heat power extraction and some high power engines.

  12. INTEGRAL ASSESSMENT OF EFFICIENCY OF A FLEET OF AGRICULTURAL MACHINERY AND TRACTORS

    Directory of Open Access Journals (Sweden)

    V. M. Korotchenya

    2015-01-01

    Full Text Available An indicator for an integral assessment of efficiency of a fleet of agricultural machinery and tractors is proposed. Its calculating consists in multiplying partial efficiencies together: technical and price efficiency of agricultural production, and eco-efficiency of a fleet of agricultural machinery and tractors. Using an axiomatic method, the concept of efficiency of fleet was studied within broader category of productivity and in wider scales - within agriculture. The most general and obvious statements according to which efficiency of machine and tractor fleet is considered as indirectly settlement size counted proceeding from efficiency of agricultural production, were accepted as axioms. In general, efficiency is a ratio between productivity of an object in question and that of the theoretical ideal or an object with maximum productivity efficiency of which is accepted equal to unity or 100%. Technical efficiency of agricultural production characterizes the ability of an agricultural sector to produce the technically maximum output of agricultural produce obtained from the available resources (land, labor, machines, etc.. Price efficiency evaluates the ability of an agricultural sector to produce output of agricultural produce with regard to employing the optimal mix of resources given their prices. Because the theoretical ideal does not exist, efficiency of an agricultural sector, e.g. in Russia and of its fleet of agricultural machinery and tractors, is measured against agriculture of another country with maximum productivity efficiency of which is accepted as equal to unity or 100 percent. The calculation can be made on the basis of the Data Envelopment Analysis method. It is possible to calculate price and economic efficiency of Russian agriculture (fleet of agricultural machinery and tractors due to use its domestic prices.

  13. Window of cold nuclear fusion and biased-pulse electrolysis experiment

    International Nuclear Information System (INIS)

    Takahashi, Akito; Jida, Toshiyuki; Maekawa, Fujio; Sugimoto, Hisashi; Yoshida, Shigeo

    1989-01-01

    Based on the electron screening effect and the excitation of deuteron harmonic oscillators in palladium lattice, theoretical aspects are given to explain the cold fusion phenomena and the possibility of nuclear heating. A narrow window is proposed to meet ≅ 10 watts per cubic centimeter for the nuclear heating, by the hypothetical excitation-screening model. A relatively wide window is feasible to meet a few fusion events per second per cc under the non-stationary conditions of deuteron-charging and discharging. For stationary lattice conditions, the probability of cold fusion is not feasible at all. To confirm the cold fusion phenomena, a heavy water electrolysis experiment was carried out using biased-pulse-electrolytic currents, expecting the enhancement of cold fusion events under charging and discharging of deuterons. For the neutron detection, a cross-checking system between a recoil-proton scintillation detector and a 3 He thermal neutron detector was employed to see coincident time-patterns of neutron emission from an electrolysis cell. To check the energy of emitted neutrons, pulse height spectrum of the recoil-proton detector was monitored. Up to the D-charging time of 300 hr, neutron yields of 1-2 n/s/cc were obtained for time-intervals of 60-200 hr. From the recoil-proton spectra, it was confirmed that 2.45 MeV neutrons by the D(d, n) 3 He fusion branch were emitted. The observed time-patterns of neutron emission suggest the existence of cold fusion under the charging and discharging conditions. (orig.)

  14. Control Systems of Rubber Dryer Machinery Components Using Programmable Logic Control (PLC)

    Science.gov (United States)

    Hendra; Yulianto, A. S.; Indriani, A.; Hernadewita; Hermiyetti

    2018-02-01

    Application of programmable logic control (PLC) is widely used on the control systems in the many field engineering such as automotive, aviation, food processing and other industries [1-2]. PLC is simply program to control many automatic activity, easy to use, flexible and others. PLC using the ladder program to solve and regulated the control system component. In previous research, PLC was used for control system of rotary dryer machine. In this paper PLC are used for control system of motion component in the rubber dryer machinery. Component of rubber dryer machine is motors, gearbox, sprocket, heater, drying chamber and bearing. Principle working of rubber dryer machinery is wet rubber moving into the drying chamber by sprocket. Sprocket is driven by motors that conducted by PLC to moving and set of wet rubber on the drying chamber. Drying system uses greenhouse effect by making hanger dryer design in the form of line path. In this paper focused on motion control system motors and sensors drying rubber using PLC. The results show that control system of rubber dryer machinery can work in accordance control input and the time required to dry the rubber.

  15. Thermonuclear fusion

    International Nuclear Information System (INIS)

    Weisse, J.

    2000-01-01

    This document takes stock of the two ways of thermonuclear fusion research explored today: magnetic confinement fusion and inertial confinement fusion. The basic physical principles are recalled first: fundamental nuclear reactions, high temperatures, elementary properties of plasmas, ignition criterion, magnetic confinement (charged particle in a uniform magnetic field, confinement and Tokamak principle, heating of magnetized plasmas (ohmic, neutral particles, high frequency waves, other heating means), results obtained so far (scale laws and extrapolation of performances, tritium experiments, ITER project), inertial fusion (hot spot ignition, instabilities, results (Centurion-Halite program, laser experiments). The second part presents the fusion reactor and its associated technologies: principle (tritium production, heat source, neutron protection, tritium generation, materials), magnetic fusion (superconducting magnets, divertor (role, principle, realization), inertial fusion (energy vector, laser adaptation, particle beams, reaction chamber, stresses, chamber concepts (dry and wet walls, liquid walls), targets (fabrication, injection and pointing)). The third chapter concerns the socio-economic aspects of thermonuclear fusion: safety (normal operation and accidents, wastes), costs (costs structure and elementary comparison, ecological impact and external costs). (J.S.)

  16. Measurements of sputtering yields for low-energy plasma ions

    International Nuclear Information System (INIS)

    Nishi, M.; Yamada, M.; Suckewer, S.; Rosengaus, E.

    1979-04-01

    Sputtering yields of various wall/limiter materials of fusion devices have been extensively measured in the relevant plasma environment for low-energy light ions (E 14 cm -3 and electron temperature up to 10eV. Target materials used were C (graphite), Ti, Mo, Ta, W, and Fe (stainless steel). In order to study the dependence of the sputtering yields on the incident energy of ions, the target samples were held at negative bias voltage up to 300V. The sputtering yields were determined by a weight-loss method and by spectral line intensity measurements. The data obtained in the present experiment agree well with those previously obtained at the higher energies (E greater than or equal to 200eV) by other authors using different schemes; the present data also extend to substantially lower energies (E approx. > 30eV) than hitherto

  17. Safe handling and monitoring of tritium in research on nuclear fusion

    International Nuclear Information System (INIS)

    Yoshida, Yoshikazu; Naruse, Yuji

    1978-01-01

    An actual condition of technique of safety handling and monitoring of tritium in the laboratory which treated a great quantity of tritium in relation to nuclear fusion, was described. With respect to the technique of safety handling of tritium, an actual condition of the technique in the U.S.A. which had wide experience in treating a great quantity of 3 H was mainly introduced, and it was helpful to a safety measure and a reduction of tritium effluence. Glovebox, hood, and other component machinery and tools for treating 3 H were also introduced briefly. As a monitoring technique, monitoring of indoor air and air exhaust by ionization chamber-type monitor for continuous monitoring of a great quantity of gaseous tritium was mentioned. Next, monitoring of a room, the surfaces of equipments, and draining, internal exposure of the individual, and monitoring of the environment were introduced. (Kanao, N.)

  18. A quantitative measurement of binocular color fusion limit for different disparities

    Science.gov (United States)

    Chen, Zaiqing; Shi, Junsheng; Tai, Yonghan; Huang, Xiaoqiao; Yun, Lijun; Zhang, Chao

    2018-01-01

    Color asymmetry is a common phenomenon in stereoscopic display system, which can cause visual fatigue or visual discomfort. When the color difference between the left and right eyes exceeds a threshold value, named binocular color fusion limit, color rivalry is said to occur. The most important information brought by stereoscopic displays is the depth perception produced by the disparity. As the stereo pair stimuli are presented separately to both eyes with disparities and those two monocular stimuli differ in color but share an iso-luminance polarity, it is possible for stereopsis and color rivalry to coexist. In this paper, we conducted an experiment to measure the color fusion limit for different disparity levels. In particular, it examines how the magnitude and sign of disparity affect the binocular color fusion limit that yields a fused, stable stereoscopic percept. The binocular color fusion limit was measured at five levels of disparities: 0, +/-60, +/-120 arc minutes for a sample color point which was selected from the 1976 CIE u'v' chromaticity diagram. The experimental results showed that fusion limit for the sample point varied with the level and sign of disparity. It was an interesting result that the fusion limit increased as the disparity decreases at crossed disparity direction (sign -), but there is almost no big change at uncrossed disparity direction (sign +). We found that color fusion was more difficult to achieve at the crossed disparity direction than at the uncrossed disparity direction.

  19. Fusion neutronics

    CERN Document Server

    Wu, Yican

    2017-01-01

    This book provides a systematic and comprehensive introduction to fusion neutronics, covering all key topics from the fundamental theories and methodologies, as well as a wide range of fusion system designs and experiments. It is the first-ever book focusing on the subject of fusion neutronics research. Compared with other nuclear devices such as fission reactors and accelerators, fusion systems are normally characterized by their complex geometry and nuclear physics, which entail new challenges for neutronics such as complicated modeling, deep penetration, low simulation efficiency, multi-physics coupling, etc. The book focuses on the neutronics characteristics of fusion systems and introduces a series of theories and methodologies that were developed to address the challenges of fusion neutronics, and which have since been widely applied all over the world. Further, it introduces readers to neutronics design’s unique principles and procedures, experimental methodologies and technologies for fusion systems...

  20. Vibration Feature Extraction and Analysis for Fault Diagnosis of Rotating Machinery-A Literature Survey

    Directory of Open Access Journals (Sweden)

    Saleem Riaz

    2017-02-01

    Full Text Available Safety, reliability, efficiency and performance of rotating machinery in all industrial applications are the main concerns. Rotating machines are widely used in various industrial applications. Condition monitoring and fault diagnosis of rotating machinery faults are very important and often complex and labor-intensive. Feature extraction techniques play a vital role for a reliable, effective and efficient feature extraction for the diagnosis of rotating machinery. Therefore, developing effective bearing fault diagnostic method using different fault features at different steps becomes more attractive. Bearings are widely used in medical applications, food processing industries, semi-conductor industries, paper making industries and aircraft components. This paper review has demonstrated that the latest reviews applied to rotating machinery on the available a variety of vibration feature extraction. Generally literature is classified into two main groups: frequency domain, time frequency analysis. However, fault detection and diagnosis of rotating machine vibration signal processing methods to present their own limitations. In practice, most healthy ingredients faulty vibration signal from background noise and mechanical vibration signals are buried. This paper also reviews that how the advanced signal processing methods, empirical mode decomposition and interference cancellation algorithm has been investigated and developed. The condition for rotating machines based rehabilitation, prevent failures increase the availability and reduce the cost of maintenance is becoming necessary too. Rotating machine fault detection and diagnostics in developing algorithms signal processing based on a key problem is the fault feature extraction or quantification. Currently, vibration signal, fault detection and diagnosis of rotating machinery based techniques most widely used techniques. Furthermore, the researchers are widely interested to make automatic

  1. Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment.

    Science.gov (United States)

    Barouch-Bentov, Rina; Neveu, Gregory; Xiao, Fei; Beer, Melanie; Bekerman, Elena; Schor, Stanford; Campbell, Joseph; Boonyaratanakornkit, Jim; Lindenbach, Brett; Lu, Albert; Jacob, Yves; Einav, Shirit

    2016-11-01

    envelopment of HCV and other viruses lacking defined late domains is ESCRT mediated and, if so, what the entry points into the ESCRT pathway are remain unknown. Here, we report the interaction network of HCV with the ESCRT machinery and a critical role for HRS, an ESCRT-0 complex component, in HCV envelopment. Viral protein ubiquitination was discovered to be a signal for HRS binding and HCV assembly, thereby functionally compensating for the absence of late domains. These findings characterize how a virus lacking defined late domains co-opts ESCRT to bud intracellularly. Since the ESCRT machinery is essential for the life cycle of multiple viruses, better understanding of this virus-host interplay may yield targets for broad-spectrum antiviral therapies. Copyright © 2016 Barouch-Bentov et al.

  2. High Level Information Fusion (HLIF) with nested fusion loops

    Science.gov (United States)

    Woodley, Robert; Gosnell, Michael; Fischer, Amber

    2013-05-01

    Situation modeling and threat prediction require higher levels of data fusion in order to provide actionable information. Beyond the sensor data and sources the analyst has access to, the use of out-sourced and re-sourced data is becoming common. Through the years, some common frameworks have emerged for dealing with information fusion—perhaps the most ubiquitous being the JDL Data Fusion Group and their initial 4-level data fusion model. Since these initial developments, numerous models of information fusion have emerged, hoping to better capture the human-centric process of data analyses within a machine-centric framework. 21st Century Systems, Inc. has developed Fusion with Uncertainty Reasoning using Nested Assessment Characterizer Elements (FURNACE) to address challenges of high level information fusion and handle bias, ambiguity, and uncertainty (BAU) for Situation Modeling, Threat Modeling, and Threat Prediction. It combines JDL fusion levels with nested fusion loops and state-of-the-art data reasoning. Initial research has shown that FURNACE is able to reduce BAU and improve the fusion process by allowing high level information fusion (HLIF) to affect lower levels without the double counting of information or other biasing issues. The initial FURNACE project was focused on the underlying algorithms to produce a fusion system able to handle BAU and repurposed data in a cohesive manner. FURNACE supports analyst's efforts to develop situation models, threat models, and threat predictions to increase situational awareness of the battlespace. FURNACE will not only revolutionize the military intelligence realm, but also benefit the larger homeland defense, law enforcement, and business intelligence markets.

  3. Part-time farmers and accidents with agricultural machinery: a moderated mediated model on the role played by frequency of use and unsafe beliefs.

    Science.gov (United States)

    Caffaro, Federica; Roccato, Michele; Micheletti Cremasco, Margherita; Cavallo, Eugenio

    2018-01-25

    We aimed at testing a model of the direct and indirect effects of being a part-time farmer on the probability of being involved in an agricultural machinery-related accident, considering the role played by unsafe beliefs and the frequency of use of machinery. Two-hundred and fifty-two Italian men, regular users of agricultural machinery (age: Mean = 45.1 years, standard Deviation = 17.5), were administered a paper-and-pencil questionnaire addressing their relation with work, unsafe beliefs, and previous experience of machinery-related accidents. Being a part-time farmer showed a positive association with unsafe beliefs only among occasional machinery users. Unsafe beliefs in turn showed a positive association with accidents. The study gave a novel contribution to the knowledge of the chain of events connecting part-time farmers with machinery-related accidents. Preventive training interventions targeting part-timer farmers using agricultural machinery just occasionally should be developed.

  4. 2006 China Machinery and Electronical Products Trade Fair:Ample Fruits Shown

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ 2006 Malaysia China Machinery and Electronical Products Trade Fair, organized by China Council for the Promotion of International Trade(CCPIT), was held in August in Prince World Trade Center(PWTC), Kuala Lumpur.

  5. Research on prediction of agricultural machinery total power based on grey model optimized by genetic algorithm

    Science.gov (United States)

    Xie, Yan; Li, Mu; Zhou, Jin; Zheng, Chang-zheng

    2009-07-01

    Agricultural machinery total power is an important index to reflex and evaluate the level of agricultural mechanization. It is the power source of agricultural production, and is the main factors to enhance the comprehensive agricultural production capacity expand production scale and increase the income of the farmers. Its demand is affected by natural, economic, technological and social and other "grey" factors. Therefore, grey system theory can be used to analyze the development of agricultural machinery total power. A method based on genetic algorithm optimizing grey modeling process is introduced in this paper. This method makes full use of the advantages of the grey prediction model and characteristics of genetic algorithm to find global optimization. So the prediction model is more accurate. According to data from a province, the GM (1, 1) model for predicting agricultural machinery total power was given based on the grey system theories and genetic algorithm. The result indicates that the model can be used as agricultural machinery total power an effective tool for prediction.

  6. Tensile property changes of metals and irradiated to low doses with fission, fusion and spallation neutrons

    International Nuclear Information System (INIS)

    Heinisch, H.L.; Hamilton, M.L.; Sommer, W.F.; Ferguson, P.D.

    1992-01-01

    The objective of this work is to investigate the effects of the neutron energy spectrum in low dose irradiations on the microstructures and mechanical properties of metals. Radiation effects due to low doses of spallation neutrons are compared directly to those produced by fission and fusion neutrons. Yield stress changes of pure Cu, alumina-dispersion-strengthened Cu and AISI 316 stainless steel irradiated at 36-55 C in the Los Alamos Spallation Radiation Effects Facility (LASREF) are compared with earlier results of irradiations at 90 C using 14 MeV D-T fusion neutrons at the Rotating Target Neutron Source and fission reactor neutrons in the Omega West Reactor. At doses up to 0.04 displacements per atom (dpa), the yield stress changes due to the three quite different neutron spectra correlate well on the basis of dpa in the stainless steel and the Cu alloy. However, in pure Cu, the measured yield stress changes due to spallation neutrons were anomalously small and should be verified by additional irradiations. With the exception of pure Cu, the low dose, low temperature experiments reveal no fundamental differences in radiation hardening by fission, fusion or spallation neutrons when compared on the basis of dpa

  7. Muon-catalyzed fusion: A new direction in fusion research

    International Nuclear Information System (INIS)

    Jones, S.E.

    1986-01-01

    In four years of intensive research, muon-catalyzed fusion has been raised from the level of a scientific curiosity to a potential means of achieving clean fusion energy. This novel approach to fusion is based on the fact that a sub-atomic particle known as a ''muon'' can induce numerous energy-releasing fusion reactions without the need for high temperatures or plasmas. Thus, the muon serves as a catalyst to facilitate production for fusion energy. The success of the research effort stems from the recent discovery of resonances in the reaction cycle which make the muon-induced fusion process extremely efficient. Prior estimates were pessimistic in that only one fusion per muon was expected. In that case energy balance would be impossible since energy must be invested to generate the muons. However, recent work has gone approximately half-way to energy balance and further improvements are being worked on. There has been little time to assess the full implications of these discoveries. However, various ways to use muon-catalyzed fusion for electrical power production are now being explored

  8. Muon-catalyzed fusion: a new direction in fusion research

    International Nuclear Information System (INIS)

    Jones, S.E.

    1986-01-01

    In four years of intensive research, muon-catalyzed fusion has been raised from the level of a scientific curiosity to a potential means of achieving clean fusion energy. This novel approach to fusion is based on the fact that a sub-atomic particle known as a ''muon'' can induce numerous energy-releasing fusion reactions without the need for high temperatures or plasmas. Thus, the muon serves as a catalyst to facilitate production for fusion energy. The success of the research effort stems from the recent discovery of resonances in the reaction cycle which make the muon-induced fusion process extremely efficient. Prior estimates were pessimistic in that only one fusion per muon was expected. In that case energy balance would be impossible since energy must be invested to generate the muons. However, recent work has gone approximately half-way to energy balance and further improvements are being worked on. There has been little time to assess the full implications of these discoveries. However, various ways to use muon-catalyzed fusion for electrical power production are now being explored

  9. The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment

    Directory of Open Access Journals (Sweden)

    Jia Chen

    2016-11-01

    Full Text Available Epstein-Barr virus (EBV is associated with infectious mononucleosis and a variety of cancers as well as lymphoproliferative disorders in immunocompromised patients. EBV mediates viral entry into epithelial and B cells using fusion machinery composed of four glycoproteins: gB, the gH/gL complex, and gp42. gB and gH/gL are required for both epithelial and B cell fusion. The specific role of gH/gL in fusion has been the most elusive among the required herpesvirus entry glycoproteins. Previous mutational studies have focused on the ectodomain of EBV gH and not on the gH cytoplasmic tail domain (CTD. In this study, we chose to examine the function of the gH CTD by making serial gH truncation mutants as well as amino acid substitution mutants to determine the importance of the gH CTD in epithelial and B cell fusion. Truncation of 8 amino acids (aa 698 to 706 of the gH CTD resulted in diminished fusion activity using a virus-free syncytium formation assay and fusion assay. The importance of the amino acid composition of the gH CTD was also investigated by amino acid substitutions that altered the hydrophobicity or hydrophilicity of the CTD. These mutations also resulted in diminished fusion activity. Interestingly, some of the gH CTD truncation mutants and hydrophilic tail substitution mutants lost the ability to bind to gp42 and epithelial cells. In summary, our studies indicate that the gH CTD is an important functional domain.

  10. Implications of material selection on the design of packaging machinery.

    Science.gov (United States)

    Merritt, J P

    2009-01-01

    Material selection has significant implications on the design and cost of horizontal-form-fill-seal packaging machinery. To avoid excessive costs, machine redesigns and project delays, material selection must be reconciled early in the project and revisited throughout the construction of the machine.

  11. Fusion breeder

    International Nuclear Information System (INIS)

    Moir, R.W.

    1982-01-01

    The fusion breeder is a fusion reactor designed with special blankets to maximize the transmutation by 14 MeV neutrons of uranium-238 to plutonium or thorium to uranium-233 for use as a fuel for fission reactors. Breeding fissile fuels has not been a goal of the US fusion energy program. This paper suggests it is time for a policy change to make the fusion breeder a goal of the US fusion program and the US nuclear energy program. The purpose of this paper is to suggest this policy change be made and tell why it should be made, and to outline specific research and development goals so that the fusion breeder will be developed in time to meet fissile fuel needs

  12. Scattering transform and LSPTSVM based fault diagnosis of rotating machinery

    Science.gov (United States)

    Ma, Shangjun; Cheng, Bo; Shang, Zhaowei; Liu, Geng

    2018-05-01

    This paper proposes an algorithm for fault diagnosis of rotating machinery to overcome the shortcomings of classical techniques which are noise sensitive in feature extraction and time consuming for training. Based on the scattering transform and the least squares recursive projection twin support vector machine (LSPTSVM), the method has the advantages of high efficiency and insensitivity for noise signal. Using the energy of the scattering coefficients in each sub-band, the features of the vibration signals are obtained. Then, an LSPTSVM classifier is used for fault diagnosis. The new method is compared with other common methods including the proximal support vector machine, the standard support vector machine and multi-scale theory by using fault data for two systems, a motor bearing and a gear box. The results show that the new method proposed in this study is more effective for fault diagnosis of rotating machinery.

  13. THE ROLE OF POSTHARVEST MACHINERIES AND PACKAGING IN MINIMIZING AFLATOXIN CONTAMINATION IN PEANUT

    Directory of Open Access Journals (Sweden)

    Raffi Paramawati

    2016-10-01

    Full Text Available As a tropical country with relatively high humidity and temperature, Indonesia is struggling with aflatoxin which frequently contaminates peanut. Aflatoxin is a carcinogenic toxic substance that could cause liver cancer. Due to the increasing concern on food safety, the Indonesian Drugs and Foods Agency specifies the maximum aflatoxin allowed in peanut as much as 20 ppb. However, researches showed that aflatoxin contamination in peanut in Indonesia is much higher than the threshold. The study was carried out to observe the effect of using postharvest machineries and packaging  treatments on aflatoxin contamination in peanut. Reduction of postharvest processes was conducted by using series of machineries, e.g. thresher, dryer, and sheller. Packaging treatments, e.g. vacuum plastic pack, hermetic glass chamber, and polyethylene (PE plastic wrap were carried out during storage at ambient temperature (25-27°C. The results showed that using machineries in postharvest handling produced peanut free from aflatoxin contamination. However, without effective packaging, the aflatoxin level would increase during storage. Hermetic packaging could protect peanut from the mold as indicated by low level of aflatoxin contamination.

  14. Measuring neutron yield and ρR anisotropies with activation foils at the National Ignition Facility

    Directory of Open Access Journals (Sweden)

    Bleuel D.L.

    2013-11-01

    Full Text Available Neutron yields at the National Ignition Facility (NIF are measured with a suite of diagnostics, including activation of ∼20–200 g samples of materials undergoing a variety of energy-dependent neutron reactions. Indium samples were mounted on the end of a Diagnostic Instrument Manipulator (DIM, 25–50 cm from the implosion, to measure 2.45 MeV D-D fusion neutron yield. The 336.2 keV gamma rays from the 4.5 hour isomer of 115mIn produced by (n,n′ reactions are counted in high-purity germanium detectors. For capsules producing D-T fusion reactions, zirconium and copper are activated via (n,2n reactions at various locations around the target chamber and bay, measuring the 14 MeV neutron yield to accuracies on order of 7%. By mounting zirconium samples on ports at nine locations around the NIF chamber, anisotropies in the primary neutron emission due to fuel areal density asymmetries can be measured to a relative precision of 3%.

  15. Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists.

    Science.gov (United States)

    Liu, Tao; Zhang, Yong; Liu, Yan; Wang, Ying; Jia, Haiqun; Kang, Mingchao; Luo, Xiaozhou; Caballero, Dawna; Gonzalez, Jose; Sherwood, Lance; Nunez, Vanessa; Wang, Danling; Woods, Ashley; Schultz, Peter G; Wang, Feng

    2015-02-03

    On the basis of the 3D structure of a bovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have developed a versatile approach for generating human or humanized antibody agonists with excellent pharmacological properties. Using human growth hormone (hGH) and human leptin (hLeptin) as model proteins, we have demonstrated that functional human antibody CDR fusions can be efficiently engineered by grafting the native hormones into different CDRs of the humanized antibody Herceptin. The resulting Herceptin CDR fusion proteins were expressed in good yields in mammalian cells and retain comparable in vitro biological activity to the native hormones. Pharmacological studies in rodents indicated a 20- to 100-fold increase in plasma circulating half-life for these antibody agonists and significantly extended in vivo activities in the GH-deficient rat model and leptin-deficient obese mouse model for the hGH and hLeptin antibody fusions, respectively. These results illustrate the utility of antibody CDR fusions as a general and versatile strategy for generating long-acting protein therapeutics.

  16. Achievement of solid-state plasma fusion ('Cold-Fusion')

    International Nuclear Information System (INIS)

    Arata, Yoshiaki; Zhang, Yue-Chang

    1995-01-01

    Using a 'QMS' (Quadrupole Mass Spectrometer), the authors detected a significantly large amount (10 20 -10 21 [cm -3 ]) of helium ( 2 4 He), which was concluded to have been produced by a deuterium nuclear reaction within a host solid. These results were found to be fully repeatable and supported the authors' proposition that solid state plasma fusion ('Cold Fusion') can be generated in energetic deuterium Strongly Coupled Plasma ('SC-plasma'). This fusion reaction is thought to be sustained by localized 'Latticequake' in a solid-state media with the deuterium density equivalent to that of the host solid. While exploring this basic proposition, the characteristic differences when compared with ultra high temperature-state plasma fusion ('Hot Fusion') are clarified. In general, the most essential reaction product in both types of the deuterium plasma fusion is considered to be helium, irrespective of the 'well-known and/or unknown reactions', which is stored within the solid-state medium in abundance as a 'Residual Product', but which generally can not enter into nor be released from host-solid at a room temperature. Even measuring instruments with relatively poor sensitivity should be able to easily detect such residual helium. An absence of residual helium means that no nuclear fusion reaction has occurred, whereas its presence provides crucial evidence that nuclear fusion has, in fact, occurred in the solid. (author)

  17. Fusion Implementation

    International Nuclear Information System (INIS)

    Schmidt, J.A.

    2002-01-01

    If a fusion DEMO reactor can be brought into operation during the first half of this century, fusion power production can have a significant impact on carbon dioxide production during the latter half of the century. An assessment of fusion implementation scenarios shows that the resource demands and waste production associated with these scenarios are manageable factors. If fusion is implemented during the latter half of this century it will be one element of a portfolio of (hopefully) carbon dioxide limiting sources of electrical power. It is time to assess the regional implications of fusion power implementation. An important attribute of fusion power is the wide range of possible regions of the country, or countries in the world, where power plants can be located. Unlike most renewable energy options, fusion energy will function within a local distribution system and not require costly, and difficult, long distance transmission systems. For example, the East Coast of the United States is a prime candidate for fusion power deployment by virtue of its distance from renewable energy sources. As fossil fuels become less and less available as an energy option, the transmission of energy across bodies of water will become very expensive. On a global scale, fusion power will be particularly attractive for regions separated from sources of renewable energy by oceans

  18. Fusion: introduction

    International Nuclear Information System (INIS)

    Decreton, M.

    2006-01-01

    The article gives an overview and introduction to the activities of SCK-CEN's research programme on fusion. The decision to construct the ITER international nuclear fusion experiment in Cadarache is highlighted. A summary of the Belgian contributions to fusion research is given with particular emphasis on studies of radiation effects on diagnostics systems, radiation effects on remote handling sensing systems, fusion waste management and socio-economic studies

  19. The pion (muon) energy production cost in muon catalyzed fusion

    International Nuclear Information System (INIS)

    Fadeev, N.G.; Solov'ev, M.I.

    1995-01-01

    The article presents the main steps in the history of the study on the muon catalysis of nuclear fusion. The practical application of the muon catalysis phenomenon to obtain the energy gain is briefly discussed. The details of the problem to produce pion (muon) yield with minimal energy expenses have been considered. 31 refs., 4 tabs

  20. Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies.

    Science.gov (United States)

    Furnham, Nicholas; Dawson, Natalie L; Rahman, Syed A; Thornton, Janet M; Orengo, Christine A

    2016-01-29

    Enzymes, as biological catalysts, form the basis of all forms of life. How these proteins have evolved their functions remains a fundamental question in biology. Over 100 years of detailed biochemistry studies, combined with the large volumes of sequence and protein structural data now available, means that we are able to perform large-scale analyses to address this question. Using a range of computational tools and resources, we have compiled information on all experimentally annotated changes in enzyme function within 379 structurally defined protein domain superfamilies, linking the changes observed in functions during evolution to changes in reaction chemistry. Many superfamilies show changes in function at some level, although one function often dominates one superfamily. We use quantitative measures of changes in reaction chemistry to reveal the various types of chemical changes occurring during evolution and to exemplify these by detailed examples. Additionally, we use structural information of the enzymes active site to examine how different superfamilies have changed their catalytic machinery during evolution. Some superfamilies have changed the reactions they perform without changing catalytic machinery. In others, large changes of enzyme function, in terms of both overall chemistry and substrate specificity, have been brought about by significant changes in catalytic machinery. Interestingly, in some superfamilies, relatives perform similar functions but with different catalytic machineries. This analysis highlights characteristics of functional evolution across a wide range of superfamilies, providing insights that will be useful in predicting the function of uncharacterised sequences and the design of new synthetic enzymes. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  1. Electric machinery and drives in thermal power stations

    International Nuclear Information System (INIS)

    1974-01-01

    The following subjects were dealt with during the VDE meeting: 1) Requirements made by the electric network on the generators and their excitation equipment, and the influence thereof on their design; 2) requirements made by the power station process on the electric drives and the influence thereof on type and design; 3) requirements made on protective measures from the point of the electric power station machinery. (TK) [de

  2. Targeting Transcription Elongation Machinery for Breast Cancer Therapy

    Science.gov (United States)

    2017-05-01

    ABSTRACT: This project focuses on the important but under-studied role of the P-TEFb- dependent transcription elongation machinery in human breast...molecule CDK9 inhibitors can be used to halt breast cancer metastasis. 8 experimental groups to test various drug dosage and frequency regimes will...tumor cells, which are said to be ’ addicted ’ to this protein. Consistently, pharmacological inhibition of Hsp90 has demonstrated great promise in

  3. Progress in control equipment for fuel-handling machinery

    International Nuclear Information System (INIS)

    Nutting, B.A.

    1986-01-01

    The paper outlines the development of the equipment used to control the fuel-handling machinery associated with nuclear reactors, from the early electromechanical equipment, through solid-state switching logic to programmable controllers and microprocessors. The control techniques have developed along with the technology, and modern systems offer versatility, reliability and ease of design, operation and maintenance. Future trends and developments are discussed together with possible limiting factors. (author)

  4. High magnetic field induced otolith fusion in the zebrafish larvae.

    Science.gov (United States)

    Pais-Roldán, Patricia; Singh, Ajeet Pratap; Schulz, Hildegard; Yu, Xin

    2016-04-11

    Magnetoreception in animals illustrates the interaction of biological systems with the geomagnetic field (geoMF). However, there are few studies that identified the impact of high magnetic field (MF) exposure from Magnetic Resonance Imaging (MRI) scanners (>100,000 times of geoMF) on specific biological targets. Here, we investigated the effects of a 14 Tesla MRI scanner on zebrafish larvae. All zebrafish larvae aligned parallel to the B0 field, i.e. the static MF, in the MRI scanner. The two otoliths (ear stones) in the otic vesicles of zebrafish larvae older than 24 hours post fertilization (hpf) fused together after the high MF exposure as short as 2 hours, yielding a single-otolith phenotype with aberrant swimming behavior. The otolith fusion was blocked in zebrafish larvae under anesthesia or embedded in agarose. Hair cells may play an important role on the MF-induced otolith fusion. This work provided direct evidence to show that high MF interacts with the otic vesicle of zebrafish larvae and causes otolith fusion in an "all-or-none" manner. The MF-induced otolith fusion may facilitate the searching for MF sensors using genetically amenable vertebrate animal models, such as zebrafish.

  5. Fusion--fission hybrid concepts for laser-induced fusion

    International Nuclear Information System (INIS)

    Maniscalco, J.

    1976-01-01

    Fusion-fission hybrid concepts are viewed as subcritical fission reactors driven and controlled by high-energy neutrons from a laser-induced fusion reactor. Blanket designs encompassing a substantial portion of the spectrum of different fission reactor technologies are analyzed and compared by calculating their fissile-breeding and fusion-energy-multiplying characteristics. With a large number of different fission technologies to choose from, it is essential to identify more promising hybrid concepts that can then be subjected to in-depth studies that treat the engineering safety, and economic requirements as well as the neutronic aspects. In the course of neutronically analyzing and comparing several fission blanket concepts, this work has demonstrated that fusion-fission hybrids can be designed to meet a broad spectrum of fissile-breeding and fusion-energy-multiplying requirements. The neutronic results should prove to be extremely useful in formulating the technical scope of future studies concerned with evaluating the technical and economic feasibility of hybrid concepts for laser-induced fusion

  6. Recent fusion research in the National Institute for Fusion Science

    International Nuclear Information System (INIS)

    Komori, Akio; Sakakibara, Satoru; Sagara, Akio; Horiuchi, Ritoku; Yamada, Hiroshi; Takeiri, Yasuhiko

    2011-01-01

    The National Institute for Fusion Science (NIFS), which was established in 1989, promotes academic approaches toward the exploration of fusion science for steady-state helical reactor and realizes the establishment of a comprehensive understanding of toroidal plasmas as an inter-university research organization and a key center of worldwide fusion research. The Large Helical Device (LHD) Project, the Numerical Simulation Science Project, and the Fusion Engineering Project are organized for early realization of net current free fusion reactor, and their recent activities are described in this paper. The LHD has been producing high-performance plasmas comparable to those of large tokamaks, and several new findings with regard to plasma physics have been obtained. The numerical simulation science project contributes understanding and systemization of the physical mechanisms of plasma confinement in fusion plasmas and explores complexity science of a plasma for realization of the numerical test reactor. In the fusion engineering project, the design of the helical fusion reactor has progressed based on the development of superconducting coils, the blanket, fusion materials and tritium handling. (author)

  7. Viral membrane fusion

    International Nuclear Information System (INIS)

    Harrison, Stephen C.

    2015-01-01

    Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function. Despite a variety of molecular architectures, these proteins facilitate fusion by essentially the same generic mechanism. Stimulated by a signal associated with arrival at the cell to be infected (e.g., receptor or co-receptor binding, proton binding in an endosome), they undergo a series of conformational changes. A hydrophobic segment (a “fusion loop” or “fusion peptide”) engages the target-cell membrane and collapse of the bridging intermediate thus formed draws the two membranes (virus and cell) together. We know of three structural classes for viral fusion proteins. Structures for both pre- and postfusion conformations of illustrate the beginning and end points of a process that can be probed by single-virion measurements of fusion kinetics. - Highlights: • Viral fusion proteins overcome the high energy barrier to lipid bilayer merger. • Different molecular structures but the same catalytic mechanism. • Review describes properties of three known fusion-protein structural classes. • Single-virion fusion experiments elucidate mechanism

  8. Viral membrane fusion

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Stephen C., E-mail: harrison@crystal.harvard.edu

    2015-05-15

    Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function. Despite a variety of molecular architectures, these proteins facilitate fusion by essentially the same generic mechanism. Stimulated by a signal associated with arrival at the cell to be infected (e.g., receptor or co-receptor binding, proton binding in an endosome), they undergo a series of conformational changes. A hydrophobic segment (a “fusion loop” or “fusion peptide”) engages the target-cell membrane and collapse of the bridging intermediate thus formed draws the two membranes (virus and cell) together. We know of three structural classes for viral fusion proteins. Structures for both pre- and postfusion conformations of illustrate the beginning and end points of a process that can be probed by single-virion measurements of fusion kinetics. - Highlights: • Viral fusion proteins overcome the high energy barrier to lipid bilayer merger. • Different molecular structures but the same catalytic mechanism. • Review describes properties of three known fusion-protein structural classes. • Single-virion fusion experiments elucidate mechanism.

  9. Hybrid Fusion for Biometrics: Combining Score-level and Decision-level Fusion

    NARCIS (Netherlands)

    Tao, Q.; Veldhuis, Raymond N.J.

    2008-01-01

    A general framework of fusion at decision level, which works on ROCs instead of matching scores, is investigated. Under this framework, we further propose a hybrid fusion method, which combines the score-level and decision-level fusions, taking advantage of both fusion modes. The hybrid fusion

  10. Application of logical analysis of data to machinery-related accident prevention based on scarce data

    International Nuclear Information System (INIS)

    Jocelyn, Sabrina; Chinniah, Yuvin; Ouali, Mohamed-Salah; Yacout, Soumaya

    2017-01-01

    This paper deals with the application of Logical Analysis of Data (LAD) to machinery-related occupational accidents, using belt-conveyor-related accidents as an example. LAD is a pattern recognition and classification approach. It exploits the advancement in information technology and computational power in order to characterize the phenomenon under study. The application of LAD to machinery-related accident prevention is innovative. Ideally, accidents do not occur regularly, and as a result, companies have little data about them. The first objective of this paper is to demonstrate the feasibility of using LAD as an algorithm to characterize a small sample of machinery-related accidents with an adequate average classification accuracy. The second is to show that LAD can be used for prevention of machinery-related accidents. The results indicate that LAD is able to characterize different types of accidents with an average classification accuracy of 72–74%, which is satisfactory when compared with other studies dealing with large amounts of data where such a level of accuracy is considered adequate. The paper shows that the quantitative information provided by LAD about the patterns generated can be used as a logical way to prioritize risk factors. This prioritization helps safety practitioners make decisions regarding safety measures for machines. - Highlights: • LAD is presented as an innovative approach to prevent machinery-related accidents. • LAD is applied to a very small database of belt-conveyor-related accidents. • Despite scarce data, LAD generates patterns with adequate classification accuracy. • The patterns characterize different types of belt-conveyor-related accidents. • The patterns are useful to belt conveyor risk identification and risk estimation.

  11. Fusion neutron detector calibration using a table-top laser generated plasma neutron source

    International Nuclear Information System (INIS)

    Hartke, R.; Symes, D.R.; Buersgens, F.; Ruggles, L.E.; Porter, J.L.; Ditmire, T.

    2005-01-01

    Using a high intensity, femtosecond laser driven neutron source, a high-sensitivity neutron detector was calibrated. This detector is designed for observing fusion neutrons at the Z accelerator in Sandia National Laboratories. Nuclear fusion from laser driven deuterium cluster explosions was used to generate a clean source of nearly monoenergetic 2.45 MeV neutrons at a well-defined time. This source can run at 10 Hz and was used to build up a clean pulse-height spectrum on scintillating neutron detectors giving a very accurate calibration for neutron yields at 2.45 MeV

  12. EXPLORING LINKS AMONG INVENTORY AND FINANCIAL PERFORMANCE IN THE AGRICULTURAL MACHINERY INDUSTRY

    Directory of Open Access Journals (Sweden)

    Dimitris Folinas

    2014-10-01

    Full Text Available The paper aims to investigate the effects of Inventory Turnover and Inventory Days on firm performance in the United Kingdom agricultural machinery industry by examining past literature reviews and empirical evidence of a primary research. Specific performance measures such as Earnings before Interest and Tax to Sales Ratio, Gross Profit to Sales Ratio, and Return on Assets are examined by conducting statistical analyses to determine the correlations between inventory and financial performance in agricultural machinery industry. The analysis of Inventory Turnover with financial performance measures doesn’t indicate any links between these variables. Furthermore, based on the results, Inventory Days plays a role in the financial performance of organisations however to varying degrees.

  13. Dynamics of complete and incomplete fusion in heavy ion collisions

    Science.gov (United States)

    Bao, Xiao Jun; Guo, Shu Qing; Zhang, Hong Fei; Li, Jun Qing

    2018-02-01

    In order to study the influence of the strong Coulomb and nuclear interactions on the dynamics of complete and incomplete fusion, we construct a new four-variable master equation (ME) so that the deformations as well as the nucleon transfer are viewed as consistently governed by MEs in the potential energy surface of the system. The calculated yields of quasifission fragments and evaporation residue cross section (ERCS) are in agreement with experimental data of hot fusion reactions. Comparing cross sections by theoretical results and experimental data, we find the improved dinuclear sysytem model also describes the transfer cross sections reasonably. The production cross sections of new neutron-rich isotopes are estimated by the multinucleon transfer reactions.

  14. FOREWORD: The XXV IAHR Symposium on Hydraulic Machinery and Systems marks half a century tradition

    Science.gov (United States)

    Susan-Resiga, Romeo

    2010-05-01

    IAHR75_logoUPT90_logoARFT_logo International Association of Hydro-Environment Engineering and Research'Politehnica' University of TimisoaraRomanian Academy - Timisoara Branch The 25th edition of the IAHR Symposium on Hydraulic Machinery and Systems, held in Timisoara, Romania, 20-24 September 2010, jointly organized by the 'Politehnica' University of Timisoara and the Romanian Academy - Timisoara Branch, marks a half century tradition of these prestigious symposia. However, it is the first time that Romania hosts such a symposium, and for good reasons. The Romanian electrical power system has a total of 20,630 MW installed power, out of which 6,422 MW in hydropower plants. The energy produced in hydropower facilities was in 2008 of 17,105 GWh from a total of 64,772 GWh electrical energy production. Moreover, for the period 2009-2015, new hydropower capacities are going to be developed, with a total of 2,157 MW installed power and an estimated 5,770 GWh/year energy production. Within the same period of time, the refurbishment, modernization and repair programs will increase the actual hydropower production with an estimated 349 GWh/year. The 'Politehnica' University of Timisoara is proud to host the 25th IAHR Symposium on Hydraulic Machinery and Systems, in the year of its 90th anniversary. The 'Politehnica' University of Timisoara is one of the largest and most well-known technical universities from Central and Eastern Europe. It was founded in 1920, a short time after the union into one state of all the Romanian territories, following the end of the First World War, in order to respond to the need engineers felt by the Romanian society at that time, within the economical development framework. During its 90 years of existence, 'Politehnica' University of Timisoara educated over 100,000 engineers, greatly appreciated both in Romania and abroad, for their competence and seriousness. King Ferdinand I of Romania said while visiting the recently established

  15. Peaceful fusion

    Energy Technology Data Exchange (ETDEWEB)

    Englert, Matthias [IANUS, TU Darmstadt (Germany)

    2014-07-01

    Like other intense neutron sources fusion reactors have in principle a potential to be used for military purposes. Although the use of fissile material is usually not considered when thinking of fusion reactors (except in fusion-fission hybrid concepts) quantitative estimates about the possible production potential of future commercial fusion reactor concepts show that significant amounts of weapon grade fissile materials could be produced even with very limited amounts of source materials. In this talk detailed burnup calculations with VESTA and MCMATH using an MCNP model of the PPCS-A will be presented. We compare different irradiation positions and the isotopic vectors of the plutonium bred in different blankets of the reactor wall with the liquid lead-lithium alloy replaced by uranium. The technical, regulatory and policy challenges to manage the proliferation risks of fusion power will be addressed as well. Some of these challenges would benefit if addressed at an early stage of the research and development process. Hence, research on fusion reactor safeguards should start as early as possible and accompany the current research on experimental fusion reactors.

  16. Plutonium-239 production rate study using a typical fusion reactor

    International Nuclear Information System (INIS)

    Faghihi, F.; Havasi, H.; Amin-Mozafari, M.

    2008-01-01

    The purpose of the present paper is to compute fissile 239 Pu material by supposed typical fusion reactor operation to make the fuel requirement for other purposes (e.g. MOX fissile fuel, etc.). It is assumed that there is a fusion reactor has a cylindrical geometry and uses uniformly distributed deuterium-tritium as fuel so that neutron wall load is taken at 10(MW)/(m 2 ) . Moreover, the reactor core is surrounded by six suggested blankets to make best performance of the physical conditions described herein. We determined neutron flux in each considered blanket as well as tritium self-sufficiency using two groups neutron energy and then computation is followed by the MCNP-4C code. Finally, material depletion according to a set of dynamical coupled differential equations is solved to estimate 239 Pu production rate. Produced 239 Pu is compared with two typical fission reactors to find performance of plutonium breeding ratio in the case of the fusion reactor. We found that 0.92% of initial U is converted into fissile Pu by our suggested fusion reactor with thermal power of 3000 MW. For comparison, 239 Pu yield of suggested large scale PWR is about 0.65% and for LMFBR is close to 1.7%. The results show that the fusion reactor has an acceptable efficiency for Pu production compared with a large scale PWR fission reactor type

  17. Tokamak Fusion Test Reactor D-T results

    International Nuclear Information System (INIS)

    Meade, D.M.

    1995-01-01

    Temperatures, densities and confinement of deuterium plasmas confined in tokamaks have been achieved within the last decade that are approaching those required for a D-T reactor. As a result, the unique phenomena present in a D-T reactor plasma (D-T plasma confinement, α confinement, α heating and possible α-driven instabilities) can now be studied in the laboratory. Recent experiments on the Tokamak Fusion Test Reactor (TFTR) have been the first magnetic fusion experiments to study plasmas with reactor fuel concentrations of tritium. The injection of about 20MW of tritium and 14MW of deuterium neutral beams into the TFTR produced a plasma with a T-to-D density ratio of about 1 and yielding a maximum fusion power of about 9.2MW. The fusion power density in the core of the plasma was about 1.8MWm -3 , approximating that expected in a D-T fusion reactor. A TFTR plasma with a T-to-D density ratio of about 1 was found to have about 20% higher energy confinement time than a comparable D plasma, indicating a confinement scaling with average ion mass A of τ E ∝A 0.6 . The core ion temperature increased from 30 to 37keV owing to a 35% improvement of ion thermal conductivity. Using the electron thermal conductivity from a comparable deuterium plasma, about 50% of the electron temperature increase from 9 to 10.6keV can be attributed to electron heating by the α particles. The approximately 5% loss of α particles, as observed on detectors near the bottom edge of the plasma, was consistent with classical first orbit loss without anomalous effects. Initial measurements have been made of the confined high energy α particles and the resultant α ash density. At fusion power levels of 7.5MW, fluctuations at the toroidal Alfven eigen-mode frequency were observed by the fluctuation diagnostics. However, no additional α loss due to the fluctuations was observed. (orig.)

  18. Cold fusion, Alchemist's dream

    International Nuclear Information System (INIS)

    Clayton, E.D.

    1989-09-01

    In this report the following topics relating to cold fusion are discussed: muon catalysed cold fusion; piezonuclear fusion; sundry explanations pertaining to cold fusion; cosmic ray muon catalysed cold fusion; vibrational mechanisms in excited states of D 2 molecules; barrier penetration probabilities within the hydrogenated metal lattice/piezonuclear fusion; branching ratios of D 2 fusion at low energies; fusion of deuterons into 4 He; secondary D+T fusion within the hydrogenated metal lattice; 3 He to 4 He ratio within the metal lattice; shock induced fusion; and anomalously high isotopic ratios of 3 He/ 4 He

  19. Progress of nuclear fusion research and review on development of fusion reactors

    International Nuclear Information System (INIS)

    1976-01-01

    Set up in October 1971, the ad hoc Committee on Survey of Nuclear Fusion Reactors has worked on overall fusion reactor aspects and definition of the future problems under four working groups of core, nuclear heat, materials and system. The presect volume is intended to provide reference materials in the field of fusion reactor engineering, prepared by members of the committee. Contents are broadly the following: concept of the nuclear fusion reactor, fusion core engineering, fusion reactor blanket engineering, fusion reactor materials engineering, and system problems in development of fusion reactors. (Mori, K.)

  20. Evaluation of a speaker identification system with and without fusion using three databases in the presence of noise and handset effects

    Science.gov (United States)

    S. Al-Kaltakchi, Musab T.; Woo, Wai L.; Dlay, Satnam; Chambers, Jonathon A.

    2017-12-01

    In this study, a speaker identification system is considered consisting of a feature extraction stage which utilizes both power normalized cepstral coefficients (PNCCs) and Mel frequency cepstral coefficients (MFCC). Normalization is applied by employing cepstral mean and variance normalization (CMVN) and feature warping (FW), together with acoustic modeling using a Gaussian mixture model-universal background model (GMM-UBM). The main contributions are comprehensive evaluations of the effect of both additive white Gaussian noise (AWGN) and non-stationary noise (NSN) (with and without a G.712 type handset) upon identification performance. In particular, three NSN types with varying signal to noise ratios (SNRs) were tested corresponding to street traffic, a bus interior, and a crowded talking environment. The performance evaluation also considered the effect of late fusion techniques based on score fusion, namely, mean, maximum, and linear weighted sum fusion. The databases employed were TIMIT, SITW, and NIST 2008; and 120 speakers were selected from each database to yield 3600 speech utterances. As recommendations from the study, mean fusion is found to yield overall best performance in terms of speaker identification accuracy (SIA) with noisy speech, whereas linear weighted sum fusion is overall best for original database recordings.

  1. Fusion power: the transition from fundamental science to fusion reactor engineering

    International Nuclear Information System (INIS)

    Post, R.F.

    1975-01-01

    The historical development of fusion research is outlined. The basics of fusion power along with fuel cost and advantages of fusion are discussed. Some quantitative requirements for fusion power are described. (MOW)

  2. Study of the role of complete fusion in the reaction of 48Ca and 56Fe with cerium and terbium

    International Nuclear Information System (INIS)

    Morrissey, D.J.

    1978-05-01

    48 Ca and 56 Fe beams from the Super HILAC accelerator were used to irradiate thick metal foils of cerium and terbium. Product gamma ray activities were detected offline and individual products were identified by half-life, gamma ray energy and gamma ray abundances. The production cross sections were iteratively fit to charge and mass dispersions to allow correction for parent decay and calculation of mass yields. From the mass yield curves contributions from quasielastic transfer, deep inelastic transfer and complete fusion reaction mechanisms were interred. Complete fusion was made up on contributions from both evaporation residue and fusion-fission products for the 48 Ca induced reactions. However, only fusion-fission products were detected in the 56 Fe induced reactions. Critical angular momenta for fusion were found to be 82 +- 8 h for 48 Ca + 159 Tb and 34 +- 5 h for 56 Fe + 140 Ce, which can be compared with 53 +- 8 h for 12 C + 197 Au (Natowitz, 1970) and 86 +- 5 h for 40 Ar + 165 Ho (Hanappe, 1973). All of these reactions lead to essentially the same compound nucleus and seem to show the dramatic decline in complete fusion for heavy ions larger than 40 Ar. The prediction of this decline was found to be beyond the model calculations of Bass and the critical distance approach of Glas and Mosel

  3. Designing a machinery control system (MCS) security testbed

    OpenAIRE

    Desso, Nathan H.

    2014-01-01

    Approved for public release; distribution is unlimited Industrial control systems (ICS) face daily cyber security threats, can have a significant impact to the security of our nation, and present a difficult challenge to defend. Critical infrastructures, including military systems like the machinery control systems (MCS) found onboard modern U.S. warships, are affected because of their use of commercial automation solutions. The increase of automated control systems within the U.S. Navy sa...

  4. Fault diagnosis in rotating machinery by vibration analysis

    International Nuclear Information System (INIS)

    Behzad, M.; Asayesh, M.

    2002-01-01

    Dynamic behavior of unbalanced bent shaft has been investigated in this research. Finite element method is used for unbalance response calculation of a bent shaft. The result shows the effect of bent on the unbalance response. The angle between bent vector and unbalance force, position and type of supports, shaft diameter and disk position can affect the outcome. The results of this research can significantly help in fault diagnosis in rotating machinery

  5. Fusion Canada

    International Nuclear Information System (INIS)

    1987-07-01

    This first issue of a quarterly newsletter announces the startup of the Tokamak de Varennes, describes Canada's national fusion program, and outlines the Canadian Fusion Fuels Technology Program. A map gives the location of the eleven principal fusion centres in Canada. (L.L.)

  6. Analysis of electric machinery and drive systems

    CERN Document Server

    Krause, Paul C; Sudhoff, Scott D; Pekarek, Steven

    2013-01-01

    Introducing a new edition of the popular reference on machine analysis Now in a fully revised and expanded edition, this widely used reference on machine analysis boasts many changes designed to address the varied needs of engineers in the electric machinery, electric drives, and electric power industries. The authors draw on their own extensive research efforts, bringing all topics up to date and outlining a variety of new approaches they have developed over the past decade. Focusing on reference frame theory that has been at the core of this work since the first edition, th

  7. Electrification of agricultural machinery; Elektrifizierung von Landmaschinen

    Energy Technology Data Exchange (ETDEWEB)

    Goetz, Manuel; Grad, Karl; Weinmann, Olrik [ZF Friedrichshafen AG, Friedrichshafen (Germany)

    2012-10-15

    As early as 2009, ZF exhibited a generator system for agricultural machinery at Agritechnica under the name Terra+ which consisted of an electric motor in the transmission housing. As part of the ElecTra project, the company is now presenting its first tractor prototype with this generator system at Agritechnica 2011. The project involves combining the electrification of the tractor's auxiliary systems with electric drives for an attachment. The electrification of the implement was carried out in cooperation with Amazone, manufacturer of implements for the agricultural industry. (orig.)

  8. Canada's Fusion Program

    International Nuclear Information System (INIS)

    Jackson, D. P.

    1990-01-01

    Canada's fusion strategy is based on developing specialized technologies in well-defined areas and supplying these technologies to international fusion projects. Two areas are specially emphasized in Canada: engineered fusion system technologies, and specific magnetic confinement and materials studies. The Canadian Fusion Fuels Technology Project focuses on the first of these areas. It tritium and fusion reactor fuel systems, remote maintenance and related safety studies. In the second area, the Centre Canadian de fusion magnetique operates the Tokamak de Varennes, the main magnetic fusion device in Canada. Both projects are partnerships linking the Government of Canada, represented by Atomic Energy of Canada Limited, and provincial governments, electrical utilities, universities and industry. Canada's program has extensive international links, through which it collaborates with the major world fusion programs, including participation in the International Thermonuclear Experimental Reactor project

  9. Atomic fusion, Gerrard atomic fusion

    International Nuclear Information System (INIS)

    Gerrard, T.H.

    1980-01-01

    In the approach to atomic fusion described here the heat produced in a fusion reaction, which is induced in a chamber by the interaction of laser beams and U.H.F. electromagnetic beams with atom streams, is transferred to a heat exchanger for electricity generation by a coolant flowing through a jacket surrounding the chamber. (U.K.)

  10. The Machinery for Enforcement of Domestic Arbitral Awards in Nigeria

    African Journals Online (AJOL)

    Nnamdi Azikiwe University Journal of International Law and Jurisprudence ... Arbitration is a private means of resolving dispute which is resorted to, chiefly because the parties choose to avoid as much as possible employing the state machinery for dispute resolution, namely the court and its dreaded time consuming ...

  11. Guidelines for meeting emission regulations for rotating machinery with mechanical seals

    Science.gov (United States)

    Mechanical seals have played a major role during many years in minimizing emissions to atmosphere in rotating machinery. A review is presented of the continuing innovations and new technologies to improve mechanical seal performance in terms of emissions.

  12. Industry sector analysis, Mexico: Oil and gas field machinery and equipment. Export Trade Information

    International Nuclear Information System (INIS)

    1990-04-01

    The Industry Sector Analyses (I.S.A.) for oil and gas field machinery and equipment contains statistical and narrative information on projected market demand, end-users, receptivity of Mexican consumers to U.S. products, the competitive situation - Mexican production, total import market, U.S. market position, foreign competition, and competitive factors, and market access - Mexican tariffs, non-tariff barriers, standards, taxes and distribution channels. The I.S.A. provides the United States industry with meaningful information regarding the Mexican market for oil and gas field machinery and equipment

  13. Outcomes of interbody fusion cages used in 1 and 2-levels anterior cervical discectomy and fusion: titanium cages versus polyetheretherketone (PEEK) cages.

    Science.gov (United States)

    Niu, Chi-Chien; Liao, Jen-Chung; Chen, Wen-Jer; Chen, Lih-Huei

    2010-07-01

    A prospective study was performed in case with cervical spondylosis who underwent anterior cervical discectomy and fusion (ACDF) with titanium or polyetheretherketone (PEEK) cages. To find out which fusion cage yielded better clinical and radiographic results. Although use of autogenous iliac-bone grafts in ACDF for cervical disc diseases remain standard surgical procedure, donor site morbidity and graft collapse or breakage are concerns. Cage technology was developed to prevent these complications. However, there is no comparison regarding the efficacy between titanium and PEEK cage. January 2005 to January 2006, 53 patients who had 1 and 2-levels ACDF with titanium or PEEK cages were evaluated. We measured the rate and amount of interspace collapse, segmental sagittal angulations, and the radiographic fusion success rate. Odom criteria were used to assess the clinical results. The fusion rate was higher in the PEEK group (100% vs. 86.5%, P=0.0335). There was no significant difference between both groups in loss of cervical lordosis (3.2 + or - 2.4 vs. 2.8 + or - 3.4, P=0.166). The mean anterior interspace collapse (1.6 + or - 1.0 mm) in the titanium group was significantly higher than the collapse of the PEEK group (0.5 + or - 0.6 mm) (PPEEK group (PPEEK group achieved an 80% rate of successful clinical outcomes, compared with 75% in the titanium group (P=0.6642). The PEEK cage is superior to the titanium cage in maintaining cervical interspace height and radiographic fusion after 1 and 2-levels anterior cervical decompression procedures.

  14. The iron-sulfur cluster assembly machineries in plants: current knowledge and open questions

    Science.gov (United States)

    Couturier, Jérémy; Touraine, Brigitte; Briat, Jean-François; Gaymard, Frédéric; Rouhier, Nicolas

    2013-01-01

    Many metabolic pathways and cellular processes occurring in most sub-cellular compartments depend on the functioning of iron-sulfur (Fe-S) proteins, whose cofactors are assembled through dedicated protein machineries. Recent advances have been made in the knowledge of the functions of individual components through a combination of genetic, biochemical and structural approaches, primarily in prokaryotes and non-plant eukaryotes. Whereas most of the components of these machineries are conserved between kingdoms, their complexity is likely increased in plants owing to the presence of additional assembly proteins and to the existence of expanded families for several assembly proteins. This review focuses on the new actors discovered in the past few years, such as glutaredoxin, BOLA and NEET proteins as well as MIP18, MMS19, TAH18, DRE2 for the cytosolic machinery, which are integrated into a model for the plant Fe-S cluster biogenesis systems. It also discusses a few issues currently subjected to an intense debate such as the role of the mitochondrial frataxin and of glutaredoxins, the functional separation between scaffold, carrier and iron-delivery proteins and the crosstalk existing between different organelles. PMID:23898337

  15. Application of Functional Link Artificial Neural Network for Prediction of Machinery Noise in Opencast Mines

    Directory of Open Access Journals (Sweden)

    Santosh Kumar Nanda

    2011-01-01

    Full Text Available Functional link-based neural network models were applied to predict opencast mining machineries noise. The paper analyzes the prediction capabilities of functional link neural network based noise prediction models vis-à-vis existing statistical models. In order to find the actual noise status in opencast mines, some of the popular noise prediction models, for example, ISO-9613-2, CONCAWE, VDI, and ENM, have been applied in mining and allied industries to predict the machineries noise by considering various attenuation factors. Functional link artificial neural network (FLANN, polynomial perceptron network (PPN, and Legendre neural network (LeNN were used to predict the machinery noise in opencast mines. The case study is based on data collected from an opencast coal mine of Orissa, India. From the present investigations, it could be concluded that the FLANN model give better noise prediction than the PPN and LeNN model.

  16. Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes.

    Science.gov (United States)

    Iwasaki, Shintaro; Kobayashi, Maki; Yoda, Mayuko; Sakaguchi, Yuriko; Katsuma, Susumu; Suzuki, Tsutomu; Tomari, Yukihide

    2010-07-30

    Small silencing RNAs--small interfering RNAs (siRNAs) or microRNAs (miRNAs)--direct posttranscriptional gene silencing of their mRNA targets as guides for the RNA-induced silencing complex (RISC). Both siRNAs and miRNAs are born double stranded. Surprisingly, loading these small RNA duplexes into Argonaute proteins, the core components of RISC, requires ATP, whereas separating the two small RNA strands within Argonaute does not. Here we show that the Hsc70/Hsp90 chaperone machinery is required to load small RNA duplexes into Argonaute proteins, but not for subsequent strand separation or target cleavage. We envision that the chaperone machinery uses ATP and mediates a conformational opening of Ago proteins so that they can receive bulky small RNA duplexes. Our data suggest that the chaperone machinery may serve as the driving force for the RISC assembly pathway. Copyright 2010 Elsevier Inc. All rights reserved.

  17. Fusion reactor safety

    International Nuclear Information System (INIS)

    1987-12-01

    Nuclear fusion could soon become a viable energy source. Work in plasma physics, fusion technology and fusion safety is progressing rapidly in a number of Member States and international collaboration continues on work aiming at the demonstration of fusion power generation. Safety of fusion reactors and technological and radiological aspects of waste management are important aspects in the development and design of fusion machines. In order to provide an international forum to review and discuss the status and the progress made since 1983 in programmes related to operational safety aspects of fusion reactors, their waste management and decommissioning concepts, the IAEA had organized the Technical Committee on ''Fusion Reactor Safety'' in Culham, 3-7 November 1986. All presentations of this meeting were divided into four sessions: 1. Statements on National-International Fusion Safety Programmes (5 papers); 2. Operation and System Safety (15 papers); 3. Waste Management and Decommissioning (5 papers); 4. Environmental Impacts (6 papers). A separate abstract was prepared for each of these 31 papers. Refs, figs, tabs

  18. Fusion systems engineering

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    Research during this report period has covered the following areas: (1) fusion reactor systems studies, (2) development of blanket processing technology for fusion reactors, (3) safety studies of fusion concepts, (4) MACKLIB-IV, a new library of nuclear response functions, (5) energy storage and power supply requirements for commercial fusion reactors, (6) blanket/shield design evaluation for commercial fusion reactors, and (7) cross section measurements, evaluations, and techniques

  19. Inertial confinement fusion and related topics

    International Nuclear Information System (INIS)

    Starodub, A. N.

    2007-01-01

    The current state of different approaches (laser fusion, light and heavy ions, electron beam) to the realization of inertial confinement fusion is considered. From comparative analysis a conclusion is made that from the viewpoint of physics, technology, safety, and economics the most realistic way to future energetics is an electric power plant based on a hybrid fission-fusion reactor which consists of an external source of neutrons (based on laser fusion) and a subcritical two-cascade nuclear blanket, which yields the energy under the action of 14 MeV neutrons. The main topics on inertial confinement fusion such as the energy driver, the interaction between plasmas and driver beam, the target design are discussed. New concept of creation of a laser driver for IFE based on generation and amplification of radiation with controllable coherence is reported. The performed studies demonstrate that the laser based on generation and amplification of radiation with controllable coherence (CCR laser) has a number of advantages as compared to conventional schemes of lasers. The carried out experiments have shown a possibility of suppression of small-scale self-focusing, formation of laser radiation pulses with required characteristics, simplification of an optical scheme of the laser, good matching of laser-target system and achievement of homogeneous irradiation and high output laser energy density without using traditional correcting systems (phase plates, adaptive optics, space filters etc.). The results of the latest experiments to reach ultimate energy characteristics of the developed laser system are also reported. Recent results from the experiments aimed at studying of the physical processes in targets under illumination by the laser with controllable coherence of radiation are presented and discussed, especially such important laser-matter interaction phenomena as absorption and scattering of the laser radiation, the laser radiation harmonic generation, X

  20. Compact magnetic fusion systems

    Energy Technology Data Exchange (ETDEWEB)

    Linford, R.K.

    1983-12-01

    If the core (first wall, blanket, shield, and magnet coils) of fusion reactor systems could be made smaller in mass and volume for a given net electric power output than is usually predicted for the mainline tokamak/sup 1/ and mirror concepts, the cost of the technological development of the core and the construction of power plants might be significantly reduced. Although progress in plasma physics and engineering approaches should continue to yield improvements in reactor designs, certain physics features of the mainline concepts may prevent major reductions in the size of the core without straining the limits of technology. However, more than a factor of ten reduction in volume and mass of the core, at constant output power, may be possible for a class of toroidal confinement concepts in which the confining magnetic fields are supported more by currents flowing in the plasma than those in the external coils. In spite of this dramatic increase in power density (ratio of total thermal output power to the volume of the core), the design of compact systems need not rely on any materials requirements that are qualitatively more difficult than those proposed for the lower-power-density mainline fusion concepts. In some respects compact systems require less of an extension of existing technology, e.g. magnetics.

  1. Compact magnetic fusion systems

    International Nuclear Information System (INIS)

    Linford, R.K.

    1983-01-01

    If the core (first wall, blanket, shield, and magnet coils) of fusion reactor systems could be made smaller in mass and volume for a given net electric power output than is usually predicted for the mainline tokamak 1 and mirror concepts, the cost of the technological development of the core and the construction of power plants might be significantly reduced. Although progress in plasma physics and engineering approaches should continue to yield improvements in reactor designs, certain physics features of the mainline concepts may prevent major reductions in the size of the core without straining the limits of technology. However, more than a factor of ten reduction in volume and mass of the core, at constant output power, may be possible for a class of toroidal confinement concepts in which the confining magnetic fields are supported more by currents flowing in the plasma than those in the external coils. In spite of this dramatic increase in power density (ratio of total thermal output power to the volume of the core), the design of compact systems need not rely on any materials requirements that are qualitatively more difficult than those proposed for the lower-power-density mainline fusion concepts. In some respects compact systems require less of an extension of existing technology, e.g. magnetics

  2. Cold fusion

    International Nuclear Information System (INIS)

    Bush, R.T.

    1991-01-01

    The transmission resonance model (TRM) is combined with some electrochemistry of the cathode surface and found to provide a good fit to new data on excess heat. For the first time, a model for cold fusion not only fits calorimetric data but also predicts optimal trigger points. This suggests that the model is meaningful and that the excess heat phenomenon claimed by Fleischmann and Pons is genuine. A crucial role is suggested for the overpotential and, in particular, for the concentration overpotential, i.e., the hydrogen overvoltage. Self-similar geometry, or scale invariance, i.e., a fractal nature, is revealed by the relative excess power function. Heat bursts are predicted with a scale invariance in time, suggesting a possible link between the TRM and chaos theory. The model describes a near-surface phenomenon with an estimated excess power yield of ∼1 kW/cm 3 Pd, as compared to 50 W/cm 3 of reactor core for a good fission reactor. Transmission resonance-induced nuclear transmutation, a new type of nuclear reaction, is strongly suggested with two types emphasized: transmission resonance-induced neutron transfer reactions yielding essentially the same end result as Teller's hypothesized catalytic neutron transfer and a three-body reaction promoted by standing de Broglie waves. In this paper suggestions for the anomalous production of heat, particles, and radiation are given

  3. DIESEL ENGINE SYSTEMS. AGRICULTURAL MACHINERY--SERVICE OCCUPATIONS, MODULE NUMBER 15.

    Science.gov (United States)

    Ohio State Univ., Columbus. Center for Vocational and Technical Education.

    ONE OF A SERIES DESIGNED TO HELP TEACHERS PREPARE POSTSECONDARY STUDENTS FOR AGRICULTURAL MACHINERY SERVICE OCCUPATIONS AS PARTS MEN, MECHANICS, MECHANIC'S HELPERS, AND SERVICE SUPERVISORS, THIS GUIDE AIMS TO DEVELOP STUDENT UNDERSTANDING OF THE CONSTRUCTION AND OPERATING PRINCIPLES OF DIESEL ENGINES. IT WAS DEVELOPED BY A NATIONAL TASK FORCE ON…

  4. Rho GTPase activity modulates paramyxovirus fusion protein-mediated cell-cell fusion

    International Nuclear Information System (INIS)

    Schowalter, Rachel M.; Wurth, Mark A.; Aguilar, Hector C.; Lee, Benhur; Moncman, Carole L.; McCann, Richard O.; Dutch, Rebecca Ellis

    2006-01-01

    The paramyxovirus fusion protein (F) promotes fusion of the viral envelope with the plasma membrane of target cells as well as cell-cell fusion. The plasma membrane is closely associated with the actin cytoskeleton, but the role of actin dynamics in paramyxovirus F-mediated membrane fusion is unclear. We examined cell-cell fusion promoted by two different paramyxovirus F proteins in three cell types in the presence of constitutively active Rho family GTPases, major cellular coordinators of actin dynamics. Reporter gene and syncytia assays demonstrated that expression of either Rac1 V12 or Cdc42 V12 could increase cell-cell fusion promoted by the Hendra or SV5 glycoproteins, though the effect was dependent on the cell type expressing the viral glycoproteins. In contrast, RhoA L63 decreased cell-cell fusion promoted by Hendra glycoproteins but had little affect on SV5 F-mediated fusion. Also, data suggested that GTPase activation in the viral glycoprotein-containing cell was primarily responsible for changes in fusion. Additionally, we found that activated Cdc42 promoted nuclear rearrangement in syncytia

  5. Updating the model TREMOD - Mobile Machinery (TREMOD-MM); Aktualisierung des Modells TREMOD - Mobile Machinery (TREMOD-MM)

    Energy Technology Data Exchange (ETDEWEB)

    Helms, Hinrich; Lambrecht, Udo; Knoerr, Wolfram [ifeu - Institut fuer Energie- und Umweltforschung Heidelberg gGmbH, Heidelberg (Germany)

    2010-05-15

    In the context of the project ''Development of a model for the computation of the air pollutant emissions and the fuel consumption of combustion engines in mobile devices and machines'', the Institute for Energy and Environmental Research GmbH (Heidelberg, Federal Republic of Germany) has created the model TREMOD-MM (TREMOD Mobile Machinery). Thus a detailed computation of the emissions from mobile devices and machines in the agriculture, construction industry, forestry and gardening as well as the sport shipping and passenger shipping can be accomplished. Strongly differentiated data are considered to the age structure, engine performance, use and emission behaviour. Thus it is possible to compute the emissions for different scenarios in high degree of detail.

  6. Overview of systems requirements for impact fusion power

    International Nuclear Information System (INIS)

    Williams, J.M.; Booth, L.A.; Krakowski, R.A.

    1979-01-01

    The development of impact fusion power reactor concepts is very limited at this time. Key systems factors in arriving at practical concepts will be conception of credible systems and subsystems which promise an acceptable overall energy balance and development of target/projectile designs and gain versus projectile energy curves which allow system design tradeoffs to be accomplished. Important system parameters will be subsystem efficiencies (particularly the accelerator), target/projectile gain as a function of target design, circulating power fraction or engineering gain, system pulse repetition rate, size/cost scaling of components, containment cavity design limits, maximum yield, minimum economical yield, minimum projectile velocity and energy, and overall economics. When more detailed conceptual designs are available, then system tradeoffs and performance optimization will be possible

  7. Production of Hev b5 as a fluorescent biotin-binding tripartite fusion protein in insect cells

    International Nuclear Information System (INIS)

    Nordlund, Henri R.; Laitinen, Olli H.; Uotila, Sanna T.H.; Kulmala, Minna; Kalkkinen, Nisse; Kulomaa, Markku S.

    2005-01-01

    The presented green fluorescent protein and streptavidin core-based tripartite fusion system provides a simple and efficient way for the production of proteins fused to it in insect cells. This fusion protein forms a unique tag, which serves as a multipurpose device enabling easy optimization of production, one-step purification via streptavidin-biotin interaction, and visualization of the fusion protein during downstream processing and in applications. In the present study, we demonstrate the successful production, purification, and detection of a natural rubber latex allergen Hev b5 with this system. We also describe the production of another NRL allergen with the system, Hev b1, which formed large aggregates and gave small yields in purification. The aggregates were detected at early steps by microscopical inspection of the infected insect cells producing this protein. Therefore, this fusion system can also be utilized as a fast indicator of the solubility of the expressed fusion proteins and may therefore be extremely useful in high-throughput expression approaches

  8. Production of Hev b5 as a fluorescent biotin-binding tripartite fusion protein in insect cells.

    Science.gov (United States)

    Nordlund, Henri R; Laitinen, Olli H; Uotila, Sanna T H; Kulmala, Minna; Kalkkinen, Nisse; Kulomaa, Markku S

    2005-10-14

    The presented green fluorescent protein and streptavidin core-based tripartite fusion system provides a simple and efficient way for the production of proteins fused to it in insect cells. This fusion protein forms a unique tag, which serves as a multipurpose device enabling easy optimization of production, one-step purification via streptavidin-biotin interaction, and visualization of the fusion protein during downstream processing and in applications. In the present study, we demonstrate the successful production, purification, and detection of a natural rubber latex allergen Hev b5 with this system. We also describe the production of another NRL allergen with the system, Hev b1, which formed large aggregates and gave small yields in purification. The aggregates were detected at early steps by microscopical inspection of the infected insect cells producing this protein. Therefore, this fusion system can also be utilized as a fast indicator of the solubility of the expressed fusion proteins and may therefore be extremely useful in high-throughput expression approaches.

  9. Inertial fusion program, January 1-June 30, 1979

    International Nuclear Information System (INIS)

    Skoberne, F.

    1981-06-01

    Progress in the development of high-energy short-pulse carbon dioxide laser systems for fusion research is reported. Improvements are outlined for the Los Alamos National Laboratory's Gemini System, which permitted over 500 shots in support of 10 different target experiments; the transformation of our eight-beam system, Helios, from a developmental to an operational facility that is capable of irradiating targets on a routine basis is described; and progress made toward completion of Antares, our 100- to 200-TW target irradiation system, is detailed. Investigations of phenomena such as phase conjugation by degenerate four-wave mixing and its applicability to laser fusion systems, and frequency multiplexing as a means toward multipulse energy extraction are summarized. Also discussed are experiments with targets designed for adiabatic compression. Progress is reported in the development of accurate diagnostics, especially for the detection of expanding ions, of neutron yield, and of x-ray emission. Significant advances in our theoretical efforts are summarized, such as the adaptation of our target design codes for use with the CRAY-1 computer, and new results leading to a better understanding of implosion phenomena are reported. The results of various fusion reactor studies are summarized, including the development of an ICF reactor blanket that offers a promising alternative to the usual lithium blanket, and the formulation of a capital-cost data base for laser fusion reactors to permit meaningful comparisons with other technologies

  10. Inertial fusion program, January 1-June 30, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Skoberne, F. (comp.)

    1981-06-01

    Progress in the development of high-energy short-pulse carbon dioxide laser systems for fusion research is reported. Improvements are outlined for the Los Alamos National Laboratory's Gemini System, which permitted over 500 shots in support of 10 different target experiments; the transformation of our eight-beam system, Helios, from a developmental to an operational facility that is capable of irradiating targets on a routine basis is described; and progress made toward completion of Antares, our 100- to 200-TW target irradiation system, is detailed. Investigations of phenomena such as phase conjugation by degenerate four-wave mixing and its applicability to laser fusion systems, and frequency multiplexing as a means toward multipulse energy extraction are summarized. Also discussed are experiments with targets designed for adiabatic compression. Progress is reported in the development of accurate diagnostics, especially for the detection of expanding ions, of neutron yield, and of x-ray emission. Significant advances in our theoretical efforts are summarized, such as the adaptation of our target design codes for use with the CRAY-1 computer, and new results leading to a better understanding of implosion phenomena are reported. The results of various fusion reactor studies are summarized, including the development of an ICF reactor blanket that offers a promising alternative to the usual lithium blanket, and the formulation of a capital-cost data base for laser fusion reactors to permit meaningful comparisons with other technologies.

  11. Barriers to fusion

    International Nuclear Information System (INIS)

    Berriman, A.C.; Butt, R.D.; Dasgupta, M.; Hinde, D.J.; Morton, C.R.; Newton, J.O.

    1999-01-01

    The fusion barrier is formed by the combination of the repulsive Coulomb and attractive nuclear forces. Recent research at the Australian National University has shown that when heavy nuclei collide, instead of a single fusion barrier, there is a set of fusion barriers. These arise due to intrinsic properties of the interacting nuclei such deformation, rotations and vibrations. Thus the range of barrier energies depends on the properties of both nuclei. The transfer of matter between nuclei, forming a neck, can also affect the fusion process. High precision data have been used to determine fusion barrier distributions for many nuclear reactions, leading to new insights into the fusion process

  12. Spallation as a dominant source of pusher-fuel and hot-spot mix in inertial confinement fusion capsules

    Science.gov (United States)

    Orth, Charles D.

    2016-02-01

    We suggest that a potentially dominant but previously neglected source of pusher-fuel and hot-spot "mix" may have been the main degradation mechanism for fusion energy yields of modern inertial confinement fusion (ICF) capsules designed and fielded to achieve high yields—not hydrodynamic instabilities. This potentially dominant mix source is the spallation of small chunks or "grains" of pusher material into the fuel regions whenever (1) the solid material adjacent to the fuel changes its phase by nucleation and (2) this solid material spalls under shock loading and sudden decompression. We describe this mix mechanism, support it with simulations and experimental evidence, and explain how to eliminate it and thereby allow higher yields for ICF capsules and possibly ignition at the National Ignition Facility.

  13. Fusion systems engineering

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    Summaries of research are included for each of the following topics: (1) fusion reactor systems studies, (2) development of blanket processing technology for fusion reactors, (3) safety studies of fusion concepts, (4) the MACK/MACKLIB system for nuclear response functions, and (5) energy storage and power supply systems for fusion reactors

  14. Hybridisation of powertrains for construction machinery; Hybridisierung von Antriebsstraengen fuer Baumaschinen

    Energy Technology Data Exchange (ETDEWEB)

    Mohr, Mark; Goetz, Manuel; Fellmann, Martin [ZF Friedrichshafen AG (Germany). Vorentwicklung Arbeitsmaschinen-Antriebe; Brehmer, Udo [ZF Passau GmbH (Germany). Entwicklung Baumaschinengetriebe

    2010-04-15

    Increasing fuel prices and increased environmental requirements lead, for construction machinery, to an increased importance of measures to reduce fuel consumption. The hybrid drive in this sector could become an economical option by using synergies for example with the commercial vehicle section. (orig.)

  15. Energy-autonomous wireless vibration sensor for condition-based maintenance of machinery

    NARCIS (Netherlands)

    Wang, Z.; Bouwens, F.; Vullers, R.; Petré, F.; Devos, S.

    2011-01-01

    This paper addresses the development of an energy-autonomous wireless vibration sensor for condition-based monitoring of machinery. Such technology plays an increasingly important role in modern manufacturing industry. In this work, energy harvesting is realized by resorting to a custom designed

  16. Motion control of multi-actuator hydraulic systems for mobile machineries: Recent advancements and future trends

    Science.gov (United States)

    Xu, Bing; Cheng, Min

    2018-06-01

    This paper presents a survey of recent advancements and upcoming trends in motion control technologies employed in designing multi-actuator hydraulic systems for mobile machineries. Hydraulic systems have been extensively used in mobile machineries due to their superior power density and robustness. However, motion control technologies of multi-actuator hydraulic systems have faced increasing challenges due to stringent emission regulations. In this study, an overview of the evolution of existing throttling control technologies is presented, including open-center and load sensing controls. Recent advancements in energy-saving hydraulic technologies, such as individual metering, displacement, and hybrid controls, are briefly summarized. The impact of energy-saving hydraulic technologies on dynamic performance and control solutions are also discussed. Then, the advanced operation methods of multi-actuator mobile machineries are reviewed, including coordinated and haptic controls. Finally, challenges and opportunities of advanced motion control technologies are presented by providing an overall consideration of energy efficiency, controllability, cost, reliability, and other aspects.

  17. Nonthermal fusion reactor concept based on Hall-effect magnetohydrodynamics plasma theory

    International Nuclear Information System (INIS)

    Witalis, E.A.

    1988-01-01

    The failure of magnetic confinement controlled thermonuclear fusion research to achieve its goal is attributed to its foundation on the incomplete MHD plasma description instead of the more general HMHD (Hall-effect magnetohydrodynamics) theory. The latter allows for a certain magnetic plasma self-confinement under described stringent conditions. A reactor concept based on the formation, acceleration, and forced disintegration of magnetized whirl structures, plasmoids, is proposed. The four conventional MHD theory objections, i.e., absence of dynamo action, fast decay caused by resistivity, non-existence of magnetic self-confinement, and negligible non-thermal fusion yield, are shown not to apply. Support for the scheme from dense plasma focus research is pointed out. (orig.) [de

  18. Robust IFE Based Order Analysis of Rotating Machinery in Virtual Instrument

    International Nuclear Information System (INIS)

    Guo, Y; Chi, Y L; Huang, Y Y; Qin, S R

    2006-01-01

    Character analysis plays an important role in fault-find and diagnosis of rotating machinery. Order analysis is one of the major methods in character analysis for the analysis of non-stationary vibration signals in run-up or coast down of rotating machinery. An order analysis method, which employs instantaneous frequency estimation based on time-frequency analysis, is introduced. In contrast with traditional order analysis methods, this method avoids the use of tachometer and other special hardware; hence it makes the application of order analysis simplified. The order analysis introduced in the paper with the character that only software is depended for order tracking makes it specially satisfy the requirement of Virtual Instruments. Corresponding order analysis items, such as order spectrum, order spectrum matrix and tracking order spectrum etc., which are applied in Virtual Instruments, are also introduced. A test example is provided to demonstrate the validity of the method presented

  19. Fusion energy 2000. Fusion energy 1998 (2001 Edition). Proceedings

    International Nuclear Information System (INIS)

    2001-01-01

    This CD-ROM contains the Proceedings of 18th International Conference on Fusion Energy. It also contains an updated version of the Fusion Energy Conference 1998 Proceedings (38 additional papers included) as well as information on how to use this CD-ROM. The 18th International Atomic Energy Agency Fusion Energy Conference (FEC-2000) was held in Sorrento, Italy, 4-10 October 2000. 573 participants from over thirty countries and three international organizations took part in this Conference. The Conference was organized by the IAEA in co-operation with the Italian National Agency for New Technology, Energy and Environment (ENEA). Around 400 papers were presented in 22 oral and 8 poster sessions on magnetic confinement experiments, inertial fusion energy, plasma heating and current drive, ITER engineering design activities, magnetic confinement theory, innovative concepts, fusion technology, and safety and environment aspects. The 17th International Atomic Energy Agency (IAEA) Fusion Energy Conference was held in Yokohama, Japan, 19-24 October 1999. This 6-day conference, which was attended by 835 participants from over 30 countries and two international organizations, was organized by the IAEA in co-operation with the Japan Atomic Energy Research Institute (JAERI). More than 360 papers plus 5 summary talks were presented in 23 oral and 8 poster sessions on magnetic confinement and experiments, inertial fusion energy, plasma heating and current drive, ITER engineering design activities, magnetic confinement theory, innovative concepts and fusion technology

  20. Fusion technology 1992

    International Nuclear Information System (INIS)

    Ferro, C.; Gasparatto, M.; Knoepfel, H.

    1993-01-01

    The aim of the biennial series of symposia on the title subject, organized by the European Fusion Laboratories, is the exchange of information on the design, construction and operation of fusion experiments and on the technology being developed for the next step devices and fusion reactors. The coverage of the volume includes the technological aspects of fusion reactors in relation to new developments, this forming a guideline for the definition of future work. These proceedings comprise three volumes and contain both the invited lectures and contributed papers presented at the symposium which was attended by 569 participants from around the globe. The 343 papers, including 12 invited papers, characterize the increasing interest of industry in the fusion programme, giving a broad and current overview on the progress and trends fusion technology is experiencing now, as well as indicating the future for fusion devices

  1. Plutonium-239 production rate study using a typical fusion reactor

    Energy Technology Data Exchange (ETDEWEB)

    Faghihi, F. [Research Center for Radiation Protection, Shiraz University, Shiraz (Iran, Islamic Republic of)], E-mail: faghihif@shirazu.ac.ir; Havasi, H.; Amin-Mozafari, M. [Department of Nuclear Engineering, School of Engineering, Shiraz University, 71348-51154 Shiraz (Iran, Islamic Republic of)

    2008-05-15

    The purpose of the present paper is to compute fissile {sup 239}Pu material by supposed typical fusion reactor operation to make the fuel requirement for other purposes (e.g. MOX fissile fuel, etc.). It is assumed that there is a fusion reactor has a cylindrical geometry and uses uniformly distributed deuterium-tritium as fuel so that neutron wall load is taken at 10(MW)/(m{sup 2}) . Moreover, the reactor core is surrounded by six suggested blankets to make best performance of the physical conditions described herein. We determined neutron flux in each considered blanket as well as tritium self-sufficiency using two groups neutron energy and then computation is followed by the MCNP-4C code. Finally, material depletion according to a set of dynamical coupled differential equations is solved to estimate {sup 239}Pu production rate. Produced {sup 239}Pu is compared with two typical fission reactors to find performance of plutonium breeding ratio in the case of the fusion reactor. We found that 0.92% of initial U is converted into fissile Pu by our suggested fusion reactor with thermal power of 3000 MW. For comparison, {sup 239}Pu yield of suggested large scale PWR is about 0.65% and for LMFBR is close to 1.7%. The results show that the fusion reactor has an acceptable efficiency for Pu production compared with a large scale PWR fission reactor type.

  2. Plutonium recovery from incinerator ash and centrifuge sludge by peroxide fusion

    International Nuclear Information System (INIS)

    Partridge, J.A.; Wheelwright, E.J.

    1975-05-01

    A technique was demonstrated for solubilizing the plutonium contained in incinerator ash and in other waste solids (such as solids accumulated by centrifugation after solvent extraction contacts in the plutonium reclamation facility at Hanford). A sodium hydroxide--sodium peroxide fusion is performed on the Pu-containing solids. The cooled melt is then dissolved in dilute nitric acid. Mild steel cans were used as ''single use'' crucibles for the fusions. Both the can and the cooled melt are dissolved in nitric acid. Fusion tests were conducted on three different cans of incinerator ash and on one can of centrifuge sludge. The series of tests demonstrated that a caustic-peroxide fusion treatment can yield 95 percent or greater recovery of plutonium from these waste solids. In most cases, quantitative recovery of the plutonium can probably be achieved by recycling the residual solids obtained in aqueous dissolution of the cooled fusion mixture. Tests with some of the incinerator ash and with the centrifuge sludge resulted in gelatinous precipitates which were difficult to separate from the nitric acid dissolver solutions. These gelatinous precipitates present what is probably the major problem to be overcome in the use of this Pu recovery method. Techniques need to be examined for making these residual solids less difficult to separate from the dissolver solution. (U.S.)

  3. Economics and yields of energy plantations: Status and potential, 1992-1993 update

    International Nuclear Information System (INIS)

    Gambles, R.L.; Kenney, W.A.

    1994-01-01

    An update is presented of a study carried out to: determine the factors affecting the cost of energy conversion feedstocks in short rotation intensive culture plantations of trees; determine the factors influencing biomass yield; identify interrelationships between the previous two objectives; present estimates of potential biomass yields and associated economics; and to identify gaps in the knowledge of the economics and yields of biomass production and their interrelationships. Developments in economics and yields in short rotation intensive silviculture for the production of biomass energy since 1991 are documented. The most substantial changes have been: the introduction of new clones in Sweden with a 20% increase in yield; illustrating the potential genetic gains achievable through selection and breeding; and halving of harvesting costs with new machinery. Harvesting costs with chipping incorporated have fallen to $51.21/dry tonne. The twin row ESM and Frobbester harvesters have lower estimated costs of $36.62 and $ 33.69 respectively. Agricultural based machines have further reduced costs to $19.42 and $26.12/dry tonne. Using these new data, three new scenarios were developed for cost of production analysis, using contract labour, farm labour or farm labour plus a subsidy. A contracted operation is now viable with an annual equivalent net value (AENV) of $35/ha. With the use of farm labour for most operations and omitting land rent, profitability increased to $127/ha. With a subsidy of $75/ha, the AENV increases to $205/ha. 25 refs., 1 fig., 3 tabs

  4. Inertial fusion energy; L'energie de fusion inertielle

    Energy Technology Data Exchange (ETDEWEB)

    Decroisette, M.; Andre, M.; Bayer, C.; Juraszek, D. [CEA Bruyeres-le-Chatel, Dir. des Systemes d' Information (CEA/DIF), 91 (France); Le Garrec, B. [CEA Centre d' Etudes Scientifiques et Techniques d' Aquitaine, 33 - Le Barp (France); Deutsch, C. [Paris-11 Univ., 91 - Orsay (France); Migus, A. [Institut d' Optique Centre scientifique, 91 - Orsay (France)

    2005-07-01

    We first recall the scientific basis of inertial fusion and then describe a generic fusion reactor with the different components: the driver, the fusion chamber, the material treatment unit, the target factory and the turbines. We analyse the options proposed at the present time for the driver and for target irradiation scheme giving the state of art for each approach. We conclude by the presentation of LMJ (laser Megajoule) and NIF (national ignition facility) projects. These facilities aim to demonstrate the feasibility of laboratory DT ignition, first step toward Inertial Fusion Energy. (authors)

  5. Fusion Power Deployment

    International Nuclear Information System (INIS)

    Schmidt, J.A.; Ogden, J.M.

    2002-01-01

    Fusion power plants could be part of a future portfolio of non-carbon dioxide producing energy supplies such as wind, solar, biomass, advanced fission power, and fossil energy with carbon dioxide sequestration. In this paper, we discuss key issues that could impact fusion energy deployment during the last half of this century. These include geographic issues such as resource availability, scale issues, energy storage requirements, and waste issues. The resource needs and waste production associated with fusion deployment in the U.S. should not pose serious problems. One important feature of fusion power is the fact that a fusion power plant should be locatable within most local or regional electrical distribution systems. For this reason, fusion power plants should not increase the burden of long distance power transmission to our distribution system. In contrast to fusion power, regional factors could play an important role in the deployment of renewable resources such as wind, solar and biomass or fossil energy with CO2 sequestration. We examine the role of these regional factors and their implications for fusion power deployment

  6. Laser fusion overview

    International Nuclear Information System (INIS)

    Nuckolls, J.

    1976-01-01

    Because of recent breakthroughs in the target area, and in the glass laser area, the scientific feasibility of laser fusion--and of inertial fusion--may be demonstrated in the early 1980's. Then the development in that time period of a suitable laser (or storage ring or other driving source) would make possible an operational inertial fusion reactor in this century. These are roughly the same time scales as projected by the Tokamak magnetic confinement approach. It thus appears that the 15-20 year earlier start by magnetic confinement fusion may be overcome. Because inertial confinement has been demonstrated, and inertial fusion reactors may operate on smaller scales than Tokamaks, laser fusion may have important technical and economic advantages

  7. Research on monitoring technology of axial gap change about high-speed rotating machinery

    International Nuclear Information System (INIS)

    Zhang Xiaochan; Liu Fanglei; Hu Shihua; Xie Qing; Li Zhen

    2014-01-01

    This paper describes that the only measuring point of high-speed rotating machinery (speed monitoring transducer) measuring the operation of the axial gap change and application. According to mechanism analysis the speed monitoring transducer's signal, prove its amplitude changes including the axial gap change information. To carry out the speed monitoring transducer qualitative and quantitative axial gap change research, Find the output signal amplitude and clearance change corresponding relationship formula of speed monitoring transducer, define the measurement method. Based on the above analsis, manufacture the single channel measurement devices and multiple unit measurement system, provide an important fault decision of high-speed rotating machinery, it can be applied to new equipment development and production. (authors)

  8. Fault Severity Estimation of Rotating Machinery Based on Residual Signals

    Directory of Open Access Journals (Sweden)

    Fan Jiang

    2012-01-01

    Full Text Available Fault severity estimation is an important part of a condition-based maintenance system, which can monitor the performance of an operation machine and enhance its level of safety. In this paper, a novel method based on statistical property and residual signals is developed for estimating the fault severity of rotating machinery. The fast Fourier transformation (FFT is applied to extract the so-called multifrequency-band energy (MFBE from the vibration signals of rotating machinery with different fault severity levels in the first stage. Usually these features of the working conditions with different fault sensitivities are different. Therefore a sensitive features-selecting algorithm is defined to construct the feature matrix and calculate the statistic parameter (mean in the second stage. In the last stage, the residual signals computed by the zero space vector are used to estimate the fault severity. Simulation and experimental results reveal that the proposed method based on statistics and residual signals is effective and feasible for estimating the severity of a rotating machine fault.

  9. Effects of high-gradient magnetic fields on living cell machinery

    International Nuclear Information System (INIS)

    Zablotskii, V; Lunov, O; Kubinova, S; Polyakova, T; Dejneka, A; Sykova, E

    2016-01-01

    A general interest in biomagnetic effects is related to fundamental studies of the influence of magnetic fields on living objects on the cellular and whole organism levels. Emerging technologies offer new directions for the use of high-gradient magnetic fields to control cell machinery and to understand the intracellular biological processes of the emerging field of nanomedicine. In this review we aim at highlighting recent advances made in identifying fundamental mechanisms by which magnetic gradient forces act on cell fate specification and cell differentiation. The review also provides an analysis of the currently available magnetic systems capable of generating magnetic fields with spatial gradients of up to 10 MT m −1 , with the focus on their suitability for use in cell therapy. Relationships between experimental factors and underlying biophysical mechanisms and assumptions that would ultimately lead to a deeper understanding of cell machinery and the development of more predictive models for the evaluation of the effects of magnetic fields on cells, tissue and organisms are comprehensively discussed. (topical review)

  10. Chaperone activity of human small heat shock protein-GST fusion proteins.

    Science.gov (United States)

    Arbach, Hannah; Butler, Caley; McMenimen, Kathryn A

    2017-07-01

    Small heat shock proteins (sHsps) are a ubiquitous part of the machinery that maintains cellular protein homeostasis by acting as molecular chaperones. sHsps bind to and prevent the aggregation of partially folded substrate proteins in an ATP-independent manner. sHsps are dynamic, forming an ensemble of structures from dimers to large oligomers through concentration-dependent equilibrium dissociation. Based on structural studies and mutagenesis experiments, it is proposed that the dimer is the smallest active chaperone unit, while larger oligomers may act as storage depots for sHsps or play additional roles in chaperone function. The complexity and dynamic nature of their structural organization has made elucidation of their chaperone function challenging. HspB1 and HspB5 are two canonical human sHsps that vary in sequence and are expressed in a wide variety of tissues. In order to determine the role of the dimer in chaperone activity, glutathione-S-transferase (GST) was genetically linked as a fusion protein to the N-terminus regions of both HspB1 and HspB5 (also known as Hsp27 and αB-crystallin, respectively) proteins in order to constrain oligomer formation of HspB1 and HspB5, by using GST, since it readily forms a dimeric structure. We monitored the chaperone activity of these fusion proteins, which suggest they primarily form dimers and monomers and function as active molecular chaperones. Furthermore, the two different fusion proteins exhibit different chaperone activity for two model substrate proteins, citrate synthase (CS) and malate dehydrogenase (MDH). GST-HspB1 prevents more aggregation of MDH compared to GST-HspB5 and wild type HspB1. However, when CS is the substrate, both GST-HspB1 and GST-HspB5 are equally effective chaperones. Furthermore, wild type proteins do not display equal activity toward the substrates, suggesting that each sHsp exhibits different substrate specificity. Thus, substrate specificity, as described here for full-length GST

  11. Vibration sensor data denoising using a time-frequency manifold for machinery fault diagnosis.

    Science.gov (United States)

    He, Qingbo; Wang, Xiangxiang; Zhou, Qiang

    2013-12-27

    Vibration sensor data from a mechanical system are often associated with important measurement information useful for machinery fault diagnosis. However, in practice the existence of background noise makes it difficult to identify the fault signature from the sensing data. This paper introduces the time-frequency manifold (TFM) concept into sensor data denoising and proposes a novel denoising method for reliable machinery fault diagnosis. The TFM signature reflects the intrinsic time-frequency structure of a non-stationary signal. The proposed method intends to realize data denoising by synthesizing the TFM using time-frequency synthesis and phase space reconstruction (PSR) synthesis. Due to the merits of the TFM in noise suppression and resolution enhancement, the denoised signal would have satisfactory denoising effects, as well as inherent time-frequency structure keeping. Moreover, this paper presents a clustering-based statistical parameter to evaluate the proposed method, and also presents a new diagnostic approach, called frequency probability time series (FPTS) spectral analysis, to show its effectiveness in fault diagnosis. The proposed TFM-based data denoising method has been employed to deal with a set of vibration sensor data from defective bearings, and the results verify that for machinery fault diagnosis the method is superior to two traditional denoising methods.

  12. Research on anisotropy of fusion-produced protons and neutrons emission from high-current plasma-focus discharges

    Energy Technology Data Exchange (ETDEWEB)

    Malinowski, K., E-mail: karol.malinowski@ncbj.gov.pl; Sadowski, M. J.; Szydlowski, A. [National Centre for Nuclear Research (NCBJ), 05-400 Otwock (Poland); Institute of Plasma Physics and Laser Microfusion (IFPiLM), 01-497 Warsaw (Poland); Skladnik-Sadowska, E.; Czaus, K.; Kwiatkowski, R.; Zaloga, D. [National Centre for Nuclear Research (NCBJ), 05-400 Otwock (Poland); Paduch, M.; Zielinska, E. [Institute of Plasma Physics and Laser Microfusion (IFPiLM), 01-497 Warsaw (Poland)

    2015-01-15

    The paper concerns fast protons and neutrons from D-D fusion reactions in a Plasma-Focus-1000U facility. Measurements were performed with nuclear-track detectors arranged in “sandwiches” of an Al-foil and two PM-355 detectors separated by a polyethylene-plate. The Al-foil eliminated all primary deuterons, but was penetrable for fast fusion protons. The foil and first PM-355 detector were penetrable for fast neutrons, which were converted into recoil-protons in the polyethylene and recorded in the second PM-355 detector. The “sandwiches” were irradiated by discharges of comparable neutron-yields. Analyses of etched tracks and computer simulations of the fusion-products behavior in the detectors were performed.

  13. Opportunistic replacement of fusion power system parts

    International Nuclear Information System (INIS)

    Day, J.A.; George, L.L.

    1981-01-01

    This paper describes a maintenance problem in a fusion power plant. The problem is to specify which life limited parts should be replaced when there is an opportunity. The objective is to minimize the cost rate of replacement parts and of maintenance actions while satisfying a power plant availability constraint. The maintenance policy is to look ahead and replace all parts that will reach their life limits within a time called a screen. Longer screens yield greater system availabilities because more parts are replaced prior to their life limits

  14. Membrane fusion

    DEFF Research Database (Denmark)

    Bendix, Pól Martin

    2015-01-01

    At Stanford University, Boxer lab, I worked on membrane fusion of small unilamellar lipid vesicles to flat membranes tethered to glass surfaces. This geometry closely resembles biological systems in which liposomes fuse to plasma membranes. The fusion mechanism was studied using DNA zippering...... between complementary strands linked to the two apposing membranes closely mimicking the zippering mechanism of SNARE fusion complexes....

  15. DETERMINATION OF AGRICULTURAL MACHINERY OPERATORS’ OPINIONS ABOUT THE CABIN COMFORT IN ESKİŞEHİR

    Directory of Open Access Journals (Sweden)

    Özge ACARBAŞ BALTACI

    2015-08-01

    Full Text Available Comfort has a great importance in the interior design of tractor and agricultural machinery cabins. Operators are exposed to muscoskeletal system disorders since they spend long time periods during the day in these vehicles. There is a few work in the literature reporting operators’ opinions about cabin comfort of these machineries. In this study, a questionnaire was conducted in order to get information about agricultural machinery operators’ opinions about the comfort of their vehicles. Tractor cabins and combine harvester machine cabins were selected as machineries. The study was conducted in Eskişehir in Turkey. Questionnaire was composed of four groups of questions and five ordered response levels were used in the Likert's scale. Demographic questions, general questions about the machine, personal evaluation questions and open ended questions were asked to the operators. After the questionnaire completed, collected data were classified according to the machine type. Frequency tables were used to present the results. Visibility and the accessibility were the most satisfied issues for the tractor operators with 55.9% and 55.4% percentages, respectively. Seat comfort has the highest satisfaction degree with 43.7% for the combine harvester operators. Cronbach Alpha reliability coefficient was used for the satisfaction questions in the applied questionnaire. The reliability of the study was high with coefficients of 0.878 and 0.940 for the tractor and combine harvester questionnaires, respectively. This study will support design and development process of new products by considering operator opinions.

  16. Controlled fusion and plasma physics

    International Nuclear Information System (INIS)

    1994-07-01

    40 papers are presented at this 21. conference on controlled fusion and plasma physics (JET). Titles are: effects of sawtooth crashes on beams ions and fusion product tritons; beta limits in H-modes and VH-modes; impurity induced neutralization of MeV energy protons in JET plasmas; lost α particle diagnostic for high-yield D-T fusion plasmas; 15-MeV proton emission from ICRF-heated plasmas; pulse compression radar reflectometry for density measurements; gamma-ray emission profile measurements during ICRH discharges; the new JET phase ICRH array; simulation of triton burn-up; parametric dependencies of JET electron temperature profiles; detached divertor plasmas; excitation of global Alfven Eigenmodes by RF heating; mechanisms of toroidal rotation; effect of shear in the radial electric field on confinement; plasma transport properties at the L-H transition; numerical study of plasma detachment conditions in JET divertor plasmas; the SOL width and the MHD interchange instability; non linear magnetic reconnection in low collisionality plasmas; topology and slowing down of high energy ion orbits; sawtooth crashes at high beta; fusion performances and alpha heating in future JET D-T plasmas; a stable route to high-beta plasmas with non-monotonic q-profiles; theory of propagation of changes to confinement; spatial distribution of gamma emissivity and fast ions during ICRF heating; multi-camera soft X-ray diagnostic; radiation phenomena and particle fluxes in the X-event; local measurement of transport parameters for laser injected trace impurities; impurity transport of high performance discharges; negative snakes and negative shear; neural-network charge exchange analysis; ion temperature anisotropy in helium neutral beam fuelling; impurity line emission due to thermal charge exchange in edge plasmas; control of convection by fuelling and pumping; VH mode accessibility and global H-mode properties; ion cyclotron emission by spontaneous emission; LHCD/ICRH synergy

  17. Atomic and plasma-material interaction data for fusion. V. 7, part B. Particle induced erosion of Be, C and W in fusion plasmas. Part B: Physical sputtering and radiation-enhanced sublimation

    International Nuclear Information System (INIS)

    Eckstein, W.; Stephens, J.A.; Clark, R.E.H.; Davis, J.W.; Haasz, A.A.; Vietzke, E.; Hirooka, Y.

    2001-01-01

    The present volume of Atomic and Plasma-Material Interaction Data for Fusion is devoted to a critical review of the physical sputtering and radiation enhanced sublimation (RES) behaviour of fusion plasma-facing materials, in particular carbon, beryllium and tungsten. The present volume is intended to provide fusion reactor designers a detailed survey and parameterization of existing, critically assessed data for the chemical erosion of plasma-facing materials by particle impact. The survey and data compilation is presented for a variety of materials containing the elements C, Be and W (including dopants in carbon materials) and impacting plasma species. The dependencies of physical sputtering and RES yields on the material temperature, incident projectile energy, and incident flux are considered. The main data compilation is presented as separate data sheets indicating the material, impacting plasma species, experimental conditions, and parameterizations in terms of analytic functions

  18. Inertial confinement fusion research and development studies. Final report, October 1979-August 1980

    International Nuclear Information System (INIS)

    Bullis, R.; Finkelman, M.; Leng, J.; Luzzi, T.; Ojalvo, I.; Powell, E.; Sedgley, D.

    1980-08-01

    These Inertial Confinement Fusion (ICF) research and development studies were selected for structural, thermal, and vacuum pumping analyses in support of the High Yield Lithium Injection Fusion Energy (HYLIFE) concept development. An additional task provided an outlined program plan for an ICF Engineering Test Facility, using the HYLIFE concept as a model, although the plan is generally applicable to other ICF concepts. The HYLIFE is one promising type of ICF concept which features a falling array of liquid lithium jets. These jets surround the fusion reaction to protect the first structural wall (FSW) of the vacuum chamber by absorbing the fusion energy, and to act as the tritium breeder. The fusion energy source is a deuterium-tritium pellet injected into the chamber every second and driven by laser or heavy ion beams. The studies performed by Grumman have considered the capabilities of specific HYLIFE features to meet life requirements and the requirement to recover to preshot conditions prior to each subsequent shot. The components under investigation were the FSW which restrains the outward motion of the liquid lithium, the nozzle plate which forms the falling jet array, the graphite shield which is in direct top view of the fusion pellet, and the vacuum pumping system. The FSW studies included structural analysis, and definition of an experimental program to validate computer codes describing lithium motion and the resulting impact on the wall

  19. Vacuum engineering for fusion research and fusion reactors

    International Nuclear Information System (INIS)

    Pittenger, L.C.

    1976-01-01

    The following topics are described: (1) surface pumping by cryogenic condensation, (2) operation of large condensing cryopumps, (3) pumping for large fusion experiments, and (4) vacuum technology for fusion reactors

  20. Fusion Power Measurement Using a Combined Neutron Spectrometer-Camera System at ITER

    International Nuclear Information System (INIS)

    Sjoestrand, Henrik; Sunden, E. Andersson; Conroy, S.; Ericsson, G.; Johnson, M. Gatu; Giacomelli, L.; Hellesen, C.; Hjalmarsson, A.; Ronchi, E.; Weiszflog, M.; Kaellne, J.

    2008-01-01

    A central task for fusion plasma diagnostics is to measure the 2.5 and 14 MeV neutron emission rate in order to determine the fusion power. A new method for determining the neutron yield has been developed at JET. It makes use of the magnetic proton recoil neutron spectrometer and a neutron camera and provides the neutron yield with small systematic errors. At ITER a similar system could operate if a high-resolution, high-performance neutron spectrometer similar to the MPR was installed. In this paper, we present how such system could be implemented and how well it would perform under different assumption of plasma scenarios and diagnostic capabilities. It is found that the systematic uncertainty for using such a system as an absolute calibration reference is as low as 3% and hence it would be an excellent candidate for the calibration of neutron monitors such as fission chambers. It is also shown that the system could provide a 1 ms time resolved estimation of the neutron rate with a total uncertainty of 5%

  1. Nuclear fusion

    International Nuclear Information System (INIS)

    Al-zaelic, M.M.

    2013-01-01

    Nuclear fusion can be relied on to solve the global energy crisis if the process of limiting the heat produced by the fusion reaction (Plasma) is successful. Currently scientists are progressively working on this aspect whereas there are two methods to limit the heat produced by fusion reaction, the two methods are auto-restriction using laser beam and magnetic restriction through the use of magnetic fields and research is carried out to improve these two methods. It is expected that at the end of this century the nuclear fusion energy will play a vital role in overcoming the global energy crisis and for these reasons, acquiring energy through the use of nuclear fusion reactors is one of the most urge nt demands of all mankind at this time. The conclusion given is that the source of fuel for energy production is readily available and inexpensive ( hydrogen atoms) and whole process is free of risks and hazards, especially to general health and the environment . Nuclear fusion importance lies in the fact that energy produced by the process is estimated to be about four to five times the energy produced by nuclear fission. (author)

  2. Technical development of fluid machinery area

    International Nuclear Information System (INIS)

    Chung, Kyung Nam; Kim, Jin Young; Kim, Yang Ik

    2008-01-01

    In this paper, recent research activity of Hyundai Heavy Industries in the fluid machinery area is introduced. Technical development has been carried out in pumps, turbines, construction equipment, side thrusters, engine lubrication flow, etc. Here the technology of pumps and cooling of construction equipment will be dealt with. We have actively used computational fluid dynamics in the performance analysis of pump models and the design of new models of various industrial pumps or marine pumps. And a cooling analysis system composed of 3D flow analysis and 1D cooling analysis has been established, and applied to the design of cooling systems of new models of excavators and wheel loaders. The above mentioned technology is presented in details, and some future works are mentioned

  3. Circumferential fusion improves outcome in comparison with instrumented posterolateral fusion

    DEFF Research Database (Denmark)

    Videbaek, Tina S; Christensen, Finn B; Soegaard, Rikke

    2006-01-01

    with respect to all four DPQ categories: daily activities, work/leisure, anxiety/depression, and social interest. The Oswestry Disability Index supported these results (P ...STUDY DESIGN: Prospective randomized clinical study with a 5- to 9-year follow-up period. OBJECTIVE: The aim of the present study was to analyze the long-term outcome with respect to functional disability, pain, and general health of patients treated by means of circumferential lumbar fusion...... in comparison with those treated by means of instrumented posterolateral lumbar fusion. SUMMARY OF BACKGROUND DATA: Circumferential fusion has become a common procedure in lumbar spinal fusion both as a primary and salvage procedure. However, the claimed advantages of circumferential fusion over conventional...

  4. Incomplete fusion studies

    International Nuclear Information System (INIS)

    Singh, B.P.

    2011-01-01

    In order to study the incomplete fusion reaction dynamics at energies ≅ 4-7 MeV/nucleon, several experiments have been carried out using accelerator facilities available in India. The measurements presented here cover a wide range of projectile-target combinations and enhance significantly our knowledge about incomplete fusion reaction dynamics. Here, the three sets of measurements have been presented; (i) excitation functions, (ii) forward recoil range distributions and (iii) the spin distributions. The first evidence of these reactions has been obtained from the measurement and analysis of excitation functions for xn/αxn/2αxn-channels. The measured excitation functions have been analyzed within the framework of compound nucleus model. The results obtained indicate the occurrence of fusion incompleteness at low beam energies. However, in order to determine the relative contribution of complete and incomplete fusion reaction processes, the recoil range distributions of the heavy residues have also been measured and analyzed within the framework of breakup fusion model which confirmed the fusion incompleteness in several heavy ion reactions involving α-emitting reaction channels. Further, in order to study the role of l-values in these reactions the spin distributions of the residues populated in case of complete and incomplete channels have been measured and are found to be distinctly different. The analysis of the data on spin distribution measurements indicate that the mean values of driving input angular momenta associated with direct-α-emitting (incomplete fusion) channels are higher than that observed for fusion-evaporation xn or α-emitting (complete fusion) channels, and is found to increase with direct α-multiplicity in the forward cone. One of the important conclusions drawn in the present work is that, there is significant incomplete fusion contribution even at energies slightly above the barrier. Further, the projectile structure has been found to

  5. Recent Advances in Precision Machinery and Manufacturing Technology

    DEFF Research Database (Denmark)

    Liu, Chien-Hung; Hsieh, Wen-Hsiang; Chang, Zong-Yu

    2014-01-01

    Precision machinery and manufacturing technology are be- coming more important in current and future technologies. New knowledge in this field will aid in the advancement of various technologies that are needed to gain industrial competitiveness. To this end, the special issue aims to disseminate...... the latest advancements of relevant fundamental and applied research works of high quality to the inter- national community. The topics of the accepted articles in the special issue include precision manufacturing pro- cesses, measurements and control, robotics and automation, machine tools, advanced...

  6. Fusion of the subunits α and β of succinyl-CoA synthetase as a phylogenetic marker for Pezizomycotina fungi

    Directory of Open Access Journals (Sweden)

    Amanda M. Koire

    2011-01-01

    Full Text Available Gene fusions, yielding the formation of multidomain proteins, are evolutionary events that can be utilized as phylogenetic markers. Here we describe a fusion gene comprising the α and β subunits of succinyl-coA synthetase, an enzyme of the TCA cycle, in Pezizomycotina fungi. This fusion is present in all Pezizomycotina with complete genome sequences and absent from all other organisms. Phylogenetic analysis of the α and β subunits of succinyl-CoA synthetase suggests that both subunits were duplicated and retained in Pezizomycotina while one copy was lost from other fungi. One of the duplicated copies was then fused in Pezizomycotina. Our results suggest that the fusion of the α and β subunits of succinyl-CoA synthetase can be used as a molecular marker for membership in the Pezizomycotina subphylum. If a species has the fusion it can be reliably classified as Pezizomycotina, while the absence of the fusion is suggestive that the species is not a member of this subphylum.

  7. A Novel Fault Diagnosis Method for Rotating Machinery Based on a Convolutional Neural Network.

    Science.gov (United States)

    Guo, Sheng; Yang, Tao; Gao, Wei; Zhang, Chen

    2018-05-04

    Fault diagnosis is critical to ensure the safety and reliable operation of rotating machinery. Most methods used in fault diagnosis of rotating machinery extract a few feature values from vibration signals for fault diagnosis, which is a dimensionality reduction from the original signal and may omit some important fault messages in the original signal. Thus, a novel diagnosis method is proposed involving the use of a convolutional neural network (CNN) to directly classify the continuous wavelet transform scalogram (CWTS), which is a time-frequency domain transform of the original signal and can contain most of the information of the vibration signals. In this method, CWTS is formed by discomposing vibration signals of rotating machinery in different scales using wavelet transform. Then the CNN is trained to diagnose faults, with CWTS as the input. A series of experiments is conducted on the rotor experiment platform using this method. The results indicate that the proposed method can diagnose the faults accurately. To verify the universality of this method, the trained CNN was also used to perform fault diagnosis for another piece of rotor equipment, and a good result was achieved.

  8. The influence of asymmetry on mix in direct-drive inertial confinement fusion experiments

    International Nuclear Information System (INIS)

    Christensen, C.R.; Wilson, D.C.; Barnes, Cris W.; Grim, G.P.; Morgan, G.L.; Wilke, M.D.; Marshall, F.J.; Glebov, V.Yu.; Stoeckl, C.

    2004-01-01

    The mix of shell material into the fuel of inertial confinement fusion (ICF) implosions is thought to be a major cause of the failure of most ICF experiments to achieve the fusion yield predicted by computer codes. Implosion asymmetry is a simple measurable quantity that is expected to affect the mix. In order to measure the coupling of asymmetry to mix in ICF implosions, we have performed experiments on the OMEGA laser [T. R. Boehly et al., Rev. Sci. Instrum. 66, 508 (1995)] that vary the energy of each of the sixty beams individually to achieve a given fraction of L2, the second-order Legendre polynomial. Prolate, symmetric, and oblate implosions resulted. Three different fill pressures were used. Simultaneous x-ray and neutron images were obtained. The experiments were modeled with a radiation/hydrodynamics code using the multi-fluid interpenetration mix model of Scannapieco and Cheng. It fits the data well with a single value of its one adjustable parameter (0.07±0.01). This agreement is demonstrated by neutron yield, x-ray images, neutron images, and ion temperatures. The degree of decline of the neutron yield with asymmetry at different fill pressures provides a hard constraint on ICF mix modeling

  9. Outer membrane targeting of Pseudomonas aeruginosa proteins shows variable dependence on the components of Bam and Lol machineries.

    Science.gov (United States)

    Hoang, Hanh H; Nickerson, Nicholas N; Lee, Vincent T; Kazimirova, Anastasia; Chami, Mohamed; Pugsley, Anthony P; Lory, Stephen

    2011-01-01

    In Gram-negative bacteria, the Lol and Bam machineries direct the targeting of lipidated and nonlipidated proteins, respectively, to the outer membrane (OM). Using Pseudomonas aeruginosa strains with depleted levels of specific Bam and Lol proteins, we demonstrated a variable dependence of different OM proteins on these targeting pathways. Reduction in the level of BamA significantly affected the ability of the β-barrel membrane protein OprF to localize to the OM, while the targeting of three secretins that are functionally related OM proteins was less affected (PilQ and PscC) or not at all affected (XcpQ). Depletion of LolB affected all lipoproteins examined and had a variable effect on the nonlipidated proteins. While the levels of OprF, PilQ, and PscC were significantly reduced by LolB depletion, XcpQ was unaffected and was correctly localized to the OM. These results suggest that certain β-barrel proteins such as OprF primarily utilize the complete Bam machinery. The Lol machinery participates in the OM targeting of secretins to variable degrees, likely through its involvement in the assembly of lipidated Bam components. XcpQ, but not PilQ or PscC, was shown to assemble spontaneously into liposomes as multimers. This work raises the possibility that there is a gradient of utilization of Bam and Lol insertion and targeting machineries. Structural features of individual proteins, including their β-barrel content, may determine the propensity of these proteins for folding (or misfolding) during periplasmic transit and OM insertion, thereby influencing the extent of utilization of the Bam targeting machinery, respectively. Targeting of lipidated and nonlipidated proteins to the outer membrane (OM) compartment in Gram-negative bacteria involves the transfer across the periplasm utilizing the Lol and Bam machineries, respectively. We show that depletion of Bam and Lol components in Pseudomonas aeruginosa does not lead to a general OM protein translocation defect

  10. Progress in fusion technology in the U.S. magnetic fusion program

    International Nuclear Information System (INIS)

    Dowling, R.J.; Beard, D.S.; Haas, G.M.; Stone, P.M.; George, T.V.

    1987-01-01

    In this paper the authors discuss the major technological achievements that have taken place during the past few years in the U.S. magnetic fusion program which have contributed to the global efforts. The goal has been to establish the scientific and technological base required for fusion energy. To reach this goal the fusion RandD program is focused on four key technical issues: determine the optimum configuration of magnetic confinement systems; determine the properties of burning plasmas; develop materials for fusion systems; and establish the nuclear technology of fusion systems. The objective of the fusion technology efforts has been to develop advanced technologies and provide the necessary support for research of these four issues. This support is provided in a variety of areas such as: high vacuum technology, large magnetic field generation by superconducting and copper coils, high voltage and high current power supplies, electromagnetic wave and particle beam heating systems, plasma fueling, tritium breeding and handling, remote maintenance, energy recovery. The U.S. Fusion Technology Program provides major support or has the primary responsibility in each of the four key technical issues of fusion, as described in the Magnetic Fusion Program Plan of February 1985. This paper has summarized the Technology Program in terms of its activities and progress since the Proceedings of the SOFT Conference in 1984

  11. 29 CFR 1918.98 - Qualifications of machinery operators and supervisory training.

    Science.gov (United States)

    2010-07-01

    ...) Qualification of machinery operators. (1) Only an employee determined by the employer to be competent by reason...). Therefore, employers who act in accordance with the employment provisions (Title I) of the ADA (42 U.S.C... authority; elements of accidents prevention; attitudes, leadership and motivation; hazards of longshoring...

  12. FuzzyFusion: an application architecture for multisource information fusion

    Science.gov (United States)

    Fox, Kevin L.; Henning, Ronda R.

    2009-04-01

    The correlation of information from disparate sources has long been an issue in data fusion research. Traditional data fusion addresses the correlation of information from sources as diverse as single-purpose sensors to all-source multi-media information. Information system vulnerability information is similar in its diversity of sources and content, and in the desire to draw a meaningful conclusion, namely, the security posture of the system under inspection. FuzzyFusionTM, A data fusion model that is being applied to the computer network operations domain is presented. This model has been successfully prototyped in an applied research environment and represents a next generation assurance tool for system and network security.

  13. Estimation by radiation inactivation of the size of functional units governing Sendai and influenza virus fusion

    International Nuclear Information System (INIS)

    Bundo-Morita, K.; Gibson, S.; Lenard, J.

    1987-01-01

    The target sizes associated with fusion and hemolysis carried out by Sendai virus envelope glycoproteins were determined by radiation inactivation analysis. The target size for influenza virus mediated fusion with erythrocyte ghosts at pH 5.0 was also determined for comparison. Sendai-mediated fusion with erythrocyte ghosts at pH 7.0 was likewise inactivated exponentially with increasing radiation dose, yielding a target size of 60 +/- 6 kDa, a value consistent with the molecular weight of a single F-protein molecule. The inactivation curve for Sendai-mediated fusion with cardiolipin liposomes at pH 7.0, however, was more complex. Assuming a multiple target-single hit model, the target consisted of 2-3 units of ca. 60 kDa each. A similar target was seen if the liposome contained 10% gangliosides or if the reaction was measured at pH 5.0, suggesting that fusion occurred by the same mechanism at high and low pH. A target size of 261 +/- 48 kDa was found for Sendai-induced hemolysis, in contrast with influenza, which had a more complex target size for this activity. Sendai virus fusion thus occurs by different mechanisms depending upon the nature of the target membrane, since it is mediated by different functional units. Hemolysis is mediated by a functional unit different from that associated with erythrocyte ghost fusion or with cardiolipin liposome fusion

  14. Dedicated monitoring and machinery protection systems on reciprocating compressors

    Energy Technology Data Exchange (ETDEWEB)

    Grande, Alvaro; Wenisch, Markus [Hoerbiger Ventilwerke GmbH and Co KG, Wien (Austria); Jacobs, Denis [HOERBIGER do Brasil Industria de Equipamentos, Cajamar, SP (Brazil)

    2012-07-01

    Growing demands on reciprocating compressors (recips) in the process gas industry require particular solutions for machinery protection and performance monitoring systems. Compared to rotating equipment, monitoring systems for recips have to consider the special mechanical and physical characteristics, such as oscillating masses, variable vibration behaviour and varying operating conditions. Furthermore, they provide valuable information about the performance of cylinder related components allowing the operator the optimization of efficiency and availability, and therefore increase production. (author)

  15. Fault diagnosis of rotating machinery using an improved HHT based on EEMD and sensitive IMFs

    International Nuclear Information System (INIS)

    Lei, Yaguo; Zuo, Ming J

    2009-01-01

    A Hilbert–Huang transform (HHT) is a time–frequency technique and has been widely applied to analyzing vibration signals in the field of fault diagnosis of rotating machinery. It analyzes the vibration signals using intrinsic mode functions (IMFs) extracted using empirical mode decomposition (EMD). However, EMD sometimes cannot reveal the signal characteristics accurately because of the problem of mode mixing. Ensemble empirical mode decomposition (EEMD) was developed recently to alleviate this problem. The IMFs generated by EEMD have different sensitivity to faults. Some IMFs are sensitive and closely related to the faults but others are irrelevant. To enhance the accuracy of the HHT in fault diagnosis of rotating machinery, an improved HHT based on EEMD and sensitive IMFs is proposed in this paper. Simulated signals demonstrate the effectiveness of the improved HHT in diagnosing the faults of rotating machinery. Finally, the improved HHT is applied to diagnosing an early rub-impact fault of a heavy oil catalytic cracking machine set, and the application results prove that the improved HHT is superior to the HHT based on all IMFs of EMD

  16. Effects of large-angle Coulomb collisions on inertial confinement fusion plasmas.

    Science.gov (United States)

    Turrell, A E; Sherlock, M; Rose, S J

    2014-06-20

    Large-angle Coulomb collisions affect the rates of energy and momentum exchange in a plasma, and it is expected that their effects will be important in many plasmas of current research interest, including in inertial confinement fusion. Their inclusion is a long-standing problem, and the first fully self-consistent method for calculating their effects is presented. This method is applied to "burn" in the hot fuel in inertial confinement fusion capsules and finds that the yield increases due to an increase in the rate of temperature equilibration between electrons and ions which is not predicted by small-angle collision theories. The equilibration rate increases are 50%-100% for number densities of 10(30)  m(-3) and temperatures around 1 keV.

  17. Fusion technology development: role of fusion facility upgrades and fission test reactors

    International Nuclear Information System (INIS)

    Hsu, P.Y.; Deis, G.A.; Longhurst, G.R.; Miller, L.G.; Schmunk, R.E.

    1983-01-01

    The near term national fusion program is unlikely to follow the aggressive logic of the Fusion Engineering Act of 1980. Faced with level budgets, a large, new fusion facility with an engineering thrust is unlikely in the near future. Within the fusion community the idea of upgrading the existing machines (TFTR, MFTF-B) is being considered to partially mitigate the lack of a design data base to ready the nation to launch an aggressive, mission-oriented fusion program with the goal of power production. This paper examines the cost/benefit issues of using fusion upgrades to develop the technology data base which will be required to support the design and construction of the next generation of fusion machines. The extent of usefulness of the nation's fission test reactors will be examined vis-a-vis the mission of the fusion upgrades. The authors show that while fission neutrons will provide a useful test environment in terms of bulk heating and tritium breeding on a submodule scale, they can play only a supporting role in designing the integrated whole modules and systems to be used in a nuclear fusion machine

  18. Fusion technology development: role of fusion facility upgrades and fission test reactors

    International Nuclear Information System (INIS)

    Hsu, P.Y.; Deis, G.A.; Miller, L.G.; Longhurst, G.R.; Schmunk, R.E.

    1983-01-01

    The near term national fusion program is unlikely to follow the aggressive logic of the Fusion Engineering Act of 1980. Faced with level budgets, a large, new fusion facility with an engineering thrust is unlikely in the near future. Within the fusion community the idea of upgrading the existing machines (TFTR, MFTF-B) is being considered to partially mitigate the lack of a design data base to ready the nation to launch an aggressive, mission-oriented fusion program with the goal of power production. This paper examines the cost/benefit issues of using fusion upgrades to develop the technology data base which will be required to support the design and construction of the next generation of fusion machines. The extent of usefulness of the nation's fission test reactors will be examined vis-a-vis the mission of the fusion upgrades. We will show that while fission neutrons will provide a useful test environment in terms of bulk heating and tritium breeding on a submodule scale, they can play only a supporting role in designing the integrated whole modules and systems to be used in a nuclear fusion machine

  19. Abrasive Wear of Alloyed Cast Steels Applied for Heavy Machinery

    Directory of Open Access Journals (Sweden)

    Studnicki A.

    2015-03-01

    Full Text Available In the paper the results and analysis of abrasive wear studies were shown for two grades of cast steels: low-alloyed cast steel applied for heavy machinery parts such as housing, covers etc. and chromium cast steels applied for kinetic nodes of pin-sleeve type. Studies were performed using the modified in Department of Foundry pin-on-disc method.

  20. A classical approach in simple nuclear fusion reaction 1H2+1H3 using two-dimension granular molecular dynamics model

    International Nuclear Information System (INIS)

    Viridi, S.; Kurniadi, R.; Waris, A.; Perkasa, Y. S.

    2012-01-01

    Molecular dynamics in 2-D accompanied by granular model provides an opportunity to investigate binding between nuclei particles and its properties that arises during collision in a fusion reaction. A fully classical approach is used to observe the influence of initial angle of nucleus orientation to the product yielded by the reaction. As an example, a simplest fusion reaction between 1 H 2 and 1 H 3 is observed. Several products of the fusion reaction have been obtained, even the unreported ones, including temporary 2 He 4 nucleus.

  1. Direct inner shell ionization accompanying heavy ion fusion reactions

    International Nuclear Information System (INIS)

    Sujkowski, Z.

    1987-07-01

    51 V+ 40 Ar (180 MeV) fusion reaction is studied by means of K X-ray-particle-γ-ray coincidences. K X-ray yields associated with various evaporation residues are determined separately for two ionization processes: the direct ionization by the projectile prior to the nuclear interaction and the postcollisional ionization due to the internal conversion of γ-rays. Implications for possible measurements of nuclear reaction times are discussed. 24 refs., 9 figs., 2 tabs. (author)

  2. Expression, purification and characterization of a phyAm-phyCs fusion phytase*

    Science.gov (United States)

    Zou, Li-kou; Wang, Hong-ning; Pan, Xin; Tian, Guo-bao; Xie, Zi-wen; Wu, Qi; Chen, Hui; Xie, Tao; Yang, Zhi-rong

    2008-01-01

    The phyAm gene encoding acid phytase and optimized neutral phytase phyCs gene were inserted into expression vector pPIC9K in correct orientation and transformed into Pichia pastoris in order to expand the pH profile of phytase and decrease the cost of production. The fusion phytase phyAm-phyCs gene was successfully overexpressed in P. pastoris as an active and extracellular phytase. The yield of total extracellular fusion phytase activity is (25.4±0.53) U/ml at the flask scale and (159.1±2.92) U/ml for high cell-density fermentation, respectively. Purified fusion phytase exhibits an optimal temperature at 55 °C and an optimal pH at 5.5~6.0 and its relative activity remains at a relatively high level of above 70% in the range of pH 2.0 to 7.0. About 51% to 63% of its original activity remains after incubation at 75 °C to 95 °C for 10 min. Due to heavy glycosylation, the expressed fusion phytase shows a broad and diffuse band in SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis). After deglycosylation by endoglycosidase H (EndoHf), the enzyme has an apparent molecular size of 95 kDa. The characterization of the fusion phytase was compared with those of phyCs and phyAm. PMID:18600783

  3. Building the US National Fusion Grid: results from the National Fusion Collaboratory Project

    International Nuclear Information System (INIS)

    Schissel, D.P.; Burruss, J.R.; Finkelstein, A.; Flanagan, S.M.; Foster, I.T.; Fredian, T.W.; Greenwald, M.J.; Johnson, C.R.; Keahey, K.; Klasky, S.A.; Li, K.; McCune, D.C.; Papka, M.; Peng, Q.; Randerson, L.; Sanderson, A.; Stillerman, J.; Stevens, R.; Thompson, M.R.; Wallace, G.

    2004-01-01

    The US National Fusion Collaboratory Project is developing a persistent infrastructure to enable scientific collaboration for all aspects of magnetic fusion research. The project is creating a robust, user-friendly collaborative software environment and making it available to more than 1000 fusion scientists in 40 institutions who perform magnetic fusion research in the United States. In particular, the project is developing and deploying a national Fusion Energy Sciences Grid (FusionGrid) that is a system for secure sharing of computation, visualization, and data resources over the Internet. The FusionGrid goal is to allow scientists at remote sites to fully participate in experimental and computational activities as if they were working at a common site thereby creating a virtual organization of the US fusion community. The project is funded by the USDOE Office of Science, Scientific Discovery through Advanced Computing (SciDAC) Program and unites fusion and computer science researchers to directly address these challenges

  4. Fusion fuel and renewables

    International Nuclear Information System (INIS)

    Entler, Slavomir

    2015-01-01

    It is shown that fusion fuel meets all aspects applied when defining renewables. A table of definitions of renewables is presented. The sections of the paper are as follows: An industrial renewable source; Nuclear fusion; Current situation in research; Definitions of renewable sources; Energy concept of nuclear fusion; Fusion fuel; Natural energy flow; Environmental impacts; Fusion fuel assessment; Sustainable power; and Energy mix from renewables. (P.A.)

  5. Towards nuclear fusion reactors

    International Nuclear Information System (INIS)

    1993-11-01

    The results of nuclear fusion researches in JAERI are summarized. In this report, following themes are collected: the concept of fusion reactor (including ITER), fusion reactor safety, plasma confinement, fusion reactor equipment, and so on. Includes glossary. (J.P.N.)

  6. On the efficiency of conical targets for laser thermonuclear fusion

    International Nuclear Information System (INIS)

    Borovskij, A.V.; Korobkin, V.V.

    1981-01-01

    Advantages and drawbacks of conical targets (CT) for laser fusion (LF) are discussed. Possibility of the laser power reduction, laser pulse lengthening and neutron yield increase are analyzed for an ideal conical target with absolutely rigid and heat-proof walls as compared to a spherical target of the same mass. A simple theory is suggested which makes it possible to take into account an effect of walls on the fusion process in the conical target with gaseous fuel and heavy shell. Energy losses due to wall deformations and heat conduction are estimated. An influence of these effects on the neutron yield is estimated. CT used in the LF experiments are found to have serious drawbacks in comparison with spherical ones. These drawbacks are connected with the effect of walls on the processes taking place in CT. Analysis of CT, for which the effect of walls is not significant, points up some definite advantages of CT as compared with spherical one. These advantages are the possibility of laser pulse lengthening and laser power reduction in comparison with the irradiation of a sphere of an equal mass. These two positive qualities are connected with the fact that CT has large linear dimensions [ru

  7. Nuclear fusion: Pursuing the Soft [Symposium on fusion technology] option

    International Nuclear Information System (INIS)

    Kenward, M.

    1991-01-01

    Fusion research has come a long way since the fusion community held the first Symposium on fusion technology (Soft) in Britain 30 years ago. Some of the recent achievements of the Jet project are reported from this year's symposium, the 16th in the series, held in London at the beginning of September. (author)

  8. KrF laser development for fusion energy

    International Nuclear Information System (INIS)

    Wolford, Matthew F.; Sethian, John D.; Myers, Matthew C.; Giuliani, John L.; Obenschain, Stephen P.; Hegeler, Frank

    2013-01-01

    The United States Naval Research Laboratory is developing an electron beam pumped krypton fluoride laser technology for a direct drive inertial fusion energy power plant. The repetitively pulsed krypton fluoride laser technology being developed meets the fusion energy requirements for laser beam quality, wavelength, and repetition rate. The krypton fluoride laser technology is projected, based on experiments, to meet the requirements for wall plug efficiency and durability. The projected wall plug efficiency based on experiments is greater than 7 percent. The Electra laser using laser triggered gas switches has conducted continuous operation for 90,000 shots at 2.5 Hertz operation (ten hours). The Electra laser has achieved greater than 700 Joules per pulse at 1 and 2.5 Hertz repetition rate. The comparison of krypton fluoride laser performance with krypton fluoride kinetics code shows good agreement for pulse shape and laser yield. Development and operation of a durable pulse power system with solid state switches has achieved a continuous run of 11 million pulses into a resistive load at 10 Hz. (author)

  9. Comparison of cross sections for C+O reactions in the second regime of complete fusion

    International Nuclear Information System (INIS)

    Beck, C.; Haas, F.; Freeman, R.M.; Heusch, B.; Coffin, J.P.; Guillaume, G.; Rami, F.; Wagner, P.

    1985-01-01

    Kinetic energy spectra, angular distributions, and elemental yield distributions have been measured for the 12 C + 16 O, 12 C + 18 O and 13 C + 17 O reaction products over an energy range from 2 to 7 times the Coulomb barrier energy. A careful kinematic analysis of the evaporation residues and comparisons with statistical model calculations show that fusion proceeds with full momentum transfer followed by a statistical decay of the compound nucleus. The competition between complete fusion process and peripheral reactions in the 12 C + 16 O system is less important than for the 12 C + 18 O and 13 C + 17 O reactions. The unexpectedly high 12 C + 16 O complete fusion cross sections are related to the possible occurence of a superdeformation of the 28 Si compound nucleus

  10. Micromachining of inertial confinement fusion targets

    International Nuclear Information System (INIS)

    Gobby, P.L.; Salzer, L.J.; Day, R.D.

    1996-01-01

    Many experiments conducted on today's largest inertial confinement fusion drive lasers require target components with sub-millimeter dimensions, precisions of a micron or less and surface finishes measured in nanometers. For metal and plastic, techniques using direct machining with diamond tools have been developed that yield the desired parts. New techniques that will be discussed include the quick-flip locator, a magnetically held kinematic mount that has allowed the direct machining of millimeter-sized beryllium hemishells whose inside and outside surface are concentric to within 0.25 micron, and an electronic version of a tracer lathe which has produced precise azimuthal variations of less than a micron

  11. Feature-Fusion Guidelines for Image-Based Multi-Modal Biometric Fusion

    Directory of Open Access Journals (Sweden)

    Dane Brown

    2017-07-01

    Full Text Available The feature level, unlike the match score level, lacks multi-modal fusion guidelines. This work demonstrates a new approach for improved image-based biometric feature-fusion. The approach extracts and combines the face, fingerprint and palmprint at the feature level for improved human identification accuracy. Feature-fusion guidelines, proposed in our recent work, are extended by adding a new face segmentation method and the support vector machine classifier. The new face segmentation method improves the face identification equal error rate (EER by 10%. The support vector machine classifier combined with the new feature selection approach, proposed in our recent work, outperforms other classifiers when using a single training sample. Feature-fusion guidelines take the form of strengths and weaknesses as observed in the applied feature processing modules during preliminary experiments. The guidelines are used to implement an effective biometric fusion system at the feature level, using a novel feature-fusion methodology, reducing the EER of two groups of three datasets namely: SDUMLA face, SDUMLA fingerprint and IITD palmprint; MUCT Face, MCYT Fingerprint and CASIA Palmprint.

  12. Non-thermal DT yield with (D)T ICRH heating in JET

    International Nuclear Information System (INIS)

    Cottrell, G.A.; Bhatnagar, V.P.; Bures, M.; Hellsten, T.; Jacquinot, J.; Start, D.F.H.

    1989-01-01

    Projections of the (D)T fusion yield expected during fundamental ICRH heating of D in JET tritium plasmas are presented. The highest fusion multiplication factor, Q (≡P fus /P r.f. ), is achieved for a relatively high plasma density (n e0 > 5 x 10 19 m -3 ) and minority concentration ratio n D /n T ≅ 20-40% with dipole antenna (k || ∼ 7 m -1 ). The latter reduces mode conversion and maximizes the r.f. power coupled to the minority ions. We have used ray-tracing and global wave ICRH codes to calculate power deposition profiles; 80% is cyclotron damped by deuterium and 17% is coupled directly to electrons via TTMP and Landau damping. With launched r.f. power P r.f. = 12 MW deposited ∼ 0.3 m off-axis, we predict fusion powers P fus up to ∼ 8 MW for a range of JET plasmas with achieved plasma pressure N e0 T e0 - 6 x 10 20 keV m -3 and Z eff = 2. Projecting to P r.f. = 25 MW, P fus increases to 17 MW with Z eff = 2. (author)

  13. The fusion-fission hybrid

    International Nuclear Information System (INIS)

    Teller, E.

    1985-01-01

    As the history of the development of fusion energy shows, a sustained controlled fusion reaction is much more difficult to produce than rapid uncontrolled release of fusion energy. Currently, the ''magnetic bottle'' technique shows sufficient progress that it might applied for the commercial fuel production of /sup 233/U, suitable for use in fission reactors, by developing a fusion-fission hybrid. Such a device would consist of a fusion chamber core surrounded by a region containing cladded uranium pellets cooled by helium, with lithium salts also present to produce tritium to refuel the fusion process. Successful development of this hybrid might be possible within 10 y, and would provide both experience and funds for further development of controlled fusion energy

  14. Fusion power

    International Nuclear Information System (INIS)

    Hancox, R.

    1981-01-01

    The principles of fusion power, and its advantages and disadvantages, are outlined. Present research programmes and future plans directed towards the development of a fusion power reactor, are summarized. (U.K.)

  15. MODELING ENVIRONMENTAL IMPACT OF MACHINERY SECTORS TO PROMOTE SUSTAINABLE DEVELOPMENT OF THAILAND

    Directory of Open Access Journals (Sweden)

    Pruethsan Sutthichaimethee

    2016-01-01

    Full Text Available The objective of this research is to propose an indicator to evaluate environmental impacts from the machinery sectors of Thailand, leading to more sustainable consumption and production in this sector of the economy. The factors used to calculate the forward linkage, backward linkage and real benefit included the total environmental costs. The highest total environmental cost was railway equipment need to be resolved immediately because it uses natural resources in carrying capacity, higher than standard environmental cost, and contribute to low real benefit. Electric accumulator & battery, secondary special industrial machinery, motorcycle, bicycle & other carriages, and engines and turbines need to monitor closely because they are able to link to other production sectors more than other production sector do and they have high environmental cost. In order to decide the sustainable development strategy of the country, there is a need to use this research to support decision-making.

  16. Experimental approaches to heavy ion fusion

    International Nuclear Information System (INIS)

    Obayashi, H.; Fujii-e, Y.; Yamaki, T.

    1986-01-01

    As a feasibility study on heavy-ion-beam induced inertial fusion (HIF) approach, a conceptual plant design called HIBLIC-I has been worked out since 1982. The characteristic features of this design are summarized. To experimentally confirm them and prove them at least in principle, considerations are made on possible experimental programs to give substantial information on these critical phenomena. In HIBLIC-I, an accelerator complex is adopted as driver system to provide 6 beams of 208 Pb +1 ions at 15 GeV, which will be simultaneously focussed on a single shell, three layered target. The target is designed to give an energy gain of 100, so that the total beam energy of 4 MJ with 160 TW power may release 400 MJ fusion energy. A reactor chamber is cylindrical with double-walled structure made of HT-9. There are three layers of liquid Li flow inside the reactor. The innermost layer forms a Li curtain which is effective to recover the residual cavity pressure. A thick upward flow serves as coolant and tritium breeder. Tritium will be recovered by yttrium gettering system. A driver system is operated at the repetition rate of 10 Hz and supplies beams for 10 reactor chambers. Then the plant yield of fusion power becomes 4000 MWt, corresponding a net electric output of 1.5 GW. Experimental programs related to HIBLIC-I is described and discussed, including those for heavy-ion-beam experiments and proposals for lithium curtain by electron beam to clarify the key phenomena in HIBLIC-I cavity. (Nogami, K.)

  17. Recycling fusion materials

    International Nuclear Information System (INIS)

    Ooms, L.

    2005-01-01

    The inherent safety and environmental advantages of fusion power in comparison with other energy sources play an important role in the public acceptance. No waste burden for future generations is therefore one of the main arguments to decide for fusion power. The waste issue has thus been studied in several documents and the final conclusion of which it is stated that there is no permanent disposal waste needed if recycling is applied. But recycling of fusion reactor materials is far to be obvious regarding mostly the very high specific activity of the materials to be handled, the types of materials and the presence of tritium. The main objective of research performed by SCK-CEN is to study the possible ways of recycling fusion materials and analyse the challenges of the materials management from fusion reactors, based on current practices used in fission reactors and the requirements for the manufacture of fusion equipment

  18. Identification and analysis of the RNA degrading complexes and machinery of Giardia lamblia using an in silico approach.

    Science.gov (United States)

    Williams, Christopher W; Elmendorf, Heidi G

    2011-11-29

    RNA degradation is critical to the survival of all cells. With increasing evidence for pervasive transcription in cells, RNA degradation has gained recognition as a means of regulating gene expression. Yet, RNA degradation machinery has been studied extensively in only a few eukaryotic organisms, including Saccharomyces cerevisiae and humans. Giardia lamblia is a parasitic protist with unusual genomic traits: it is binucleated and tetraploid, has a very compact genome, displays a theme of genomic minimalism with cellular machinery commonly comprised of a reduced number of protein components, and has a remarkably large population of long, stable, noncoding, antisense RNAs. Here we use in silico approaches to investigate the major RNA degradation machinery in Giardia lamblia and compare it to a broad array of other parasitic protists. We have found key constituents of the deadenylation and decapping machinery and of the 5'-3' RNA degradation pathway. We have similarly found that all of the major 3'-5' RNA degradation pathways are present in Giardia, including both exosome-dependent and exosome-independent machinery. However, we observe significant loss of RNA degradation machinery genes that will result in important differences in the protein composition, and potentially functionality, of the various RNA degradation pathways. This is most apparent in the exosome, the central mediator of 3'-5' degradation, which apparently contains an altered core configuration in both Giardia and Plasmodium, with only four, instead of the canonical six, distinct subunits. Additionally the exosome in Giardia is missing both the Rrp6, Nab3, and Nrd1 proteins, known to be key regulators of noncoding transcript stability in other cells. These findings suggest that although the full complement of the major RNA degradation mechanisms were present - and likely functional - early in eukaryotic evolution, the composition and function of the complexes is more variable than previously

  19. Nuclear Fusion prize laudation Nuclear Fusion prize laudation

    Science.gov (United States)

    Burkart, W.

    2011-01-01

    Clean energy in abundance will be of critical importance to the pursuit of world peace and development. As part of the IAEA's activities to facilitate the dissemination of fusion related science and technology, the journal Nuclear Fusion is intended to contribute to the realization of such energy from fusion. In 2010, we celebrated the 50th anniversary of the IAEA journal. The excellence of research published in the journal is attested to by its high citation index. The IAEA recognizes excellence by means of an annual prize awarded to the authors of papers judged to have made the greatest impact. On the occasion of the 2010 IAEA Fusion Energy Conference in Daejeon, Republic of Korea at the welcome dinner hosted by the city of Daejeon, we celebrated the achievements of the 2009 and 2010 Nuclear Fusion prize winners. Steve Sabbagh, from the Department of Applied Physics and Applied Mathematics, Columbia University, New York is the winner of the 2009 award for his paper: 'Resistive wall stabilized operation in rotating high beta NSTX plasmas' [1]. This is a landmark paper which reports record parameters of beta in a large spherical torus plasma and presents a thorough investigation of the physics of resistive wall mode (RWM) instability. The paper makes a significant contribution to the critical topic of RWM stabilization. John Rice, from the Plasma Science and Fusion Center, MIT, Cambridge is the winner of the 2010 award for his paper: 'Inter-machine comparison of intrinsic toroidal rotation in tokamaks' [2]. The 2010 award is for a seminal paper that analyzes results across a range of machines in order to develop a universal scaling that can be used to predict intrinsic rotation. This paper has already triggered a wealth of experimental and theoretical work. I congratulate both authors and their colleagues on these exceptional papers. W. Burkart Deputy Director General Department of Nuclear Sciences and Applications International Atomic Energy Agency, Vienna

  20. Assessment of exposure to manganese in welding operations during the assembly of heavy excavation machinery accessories.

    Science.gov (United States)

    Smargiassi, A; Baldwin, M; Savard, S; Kennedy, G; Mergler, D; Zayed, J

    2000-10-01

    Welder exposure to metals in various industrial sectors is poorly characterized. We had the opportunity to carry out an exploratory study to characterize manganese exposure in welding operations in a recently established Quebec factory that assembled accessories for heavy excavation machinery. Ten workers were sampled for total manganese for at least two consecutive days out of three followed by two consecutive days for respirable manganese (with a size selective sampler with a median cut-off of 4 microns), during a typical week in the summer of 1998. Parts being welded were characterized as large or small. Small parts were those being welded on tables during subassembly. Workers were divided into two groups according to the parts they were welding. Seventy-eight percent of the total manganese exposure levels of welding operations during the assembly of large accessories of heavy excavation machinery exceeded the manganese American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value (TLV) of 0.20 mg/m3 (GM 0.24 mg/m3, n = 14) while none exceeded the TLV during the assembly of small pieces (GM 0.06 mg/m3, n = 8). Welding operations during the assembly of large heavy excavation machinery accessories may pose a significant health hazard. Considering the importance of task-related variables affecting exposure among workers, further studies are needed to better characterize exposure determinants of welding operations during the assembly of heavy excavation machinery accessories.

  1. Demountable toroidal fusion core facility for physics optimization and fusion engineering

    International Nuclear Information System (INIS)

    Bogart, S.L.; Wagner, C.E.; Krall, N.A.; Dalessandro, J.A.; Weggel, C.F.; Lund, K.O.; Sedehi, S.

    1986-01-01

    Following a successful compact ignition tokamak (CIT) experiment, a fusion facility will be required for physics optimization (POF) and fusion engineering research (FERF). The POF will address issues such as high-beta operation, current drive, impurity control, and will test geometric and configurational variations such as the spherical torus or the reversed-field pinch (RFP). The FERF will be designed to accumulate rapidly a large neutron dose in prototypical fusion subsystems exposed to radiation. Both facilities will require low-cost replacement cores and rapid replacement times. The Demountable Toroidal Fusion Core (DTFC) facility is designed to fulfill these requirements. It would be a cost-effective stepping stone between the CIT and a demonstration fusion reactor

  2. Measuring the absolute deuterium-tritium neutron yield using the magnetic recoil spectrometer at OMEGA and the NIF.

    Science.gov (United States)

    Casey, D T; Frenje, J A; Gatu Johnson, M; Séguin, F H; Li, C K; Petrasso, R D; Glebov, V Yu; Katz, J; Knauer, J P; Meyerhofer, D D; Sangster, T C; Bionta, R M; Bleuel, D L; Döppner, T; Glenzer, S; Hartouni, E; Hatchett, S P; Le Pape, S; Ma, T; MacKinnon, A; McKernan, M A; Moran, M; Moses, E; Park, H-S; Ralph, J; Remington, B A; Smalyuk, V; Yeamans, C B; Kline, J; Kyrala, G; Chandler, G A; Leeper, R J; Ruiz, C L; Cooper, G W; Nelson, A J; Fletcher, K; Kilkenny, J; Farrell, M; Jasion, D; Paguio, R

    2012-10-01

    A magnetic recoil spectrometer (MRS) has been installed and extensively used on OMEGA and the National Ignition Facility (NIF) for measurements of the absolute neutron spectrum from inertial confinement fusion implosions. From the neutron spectrum measured with the MRS, many critical implosion parameters are determined including the primary DT neutron yield, the ion temperature, and the down-scattered neutron yield. As the MRS detection efficiency is determined from first principles, the absolute DT neutron yield is obtained without cross-calibration to other techniques. The MRS primary DT neutron measurements at OMEGA and the NIF are shown to be in excellent agreement with previously established yield diagnostics on OMEGA, and with the newly commissioned nuclear activation diagnostics on the NIF.

  3. Some fusion perspectives

    International Nuclear Information System (INIS)

    McNally, J.R. Jr.

    1977-01-01

    Some of the concepts of nuclear fusion reactions, advanced fusion fuels, environmental impacts, etc., are explored using the following general outline: I. Principles of Fusion (Nuclear Fuels and Reactions, Lawson Condition, n tau vs T, Nuclear Burn Characteristics); II. Magnetic Mirror Possibilities (the Ion Layer and Electron Layer, Exponential Build-up at MeV energies, Lorentz trapping at GeV energies); III. Pellet Fuel Fusion Prospects (Advanced Pellet Fuel Fusion Prospects, Burn Characteristics and Applications, Excitation-heating Prospects for Runaway Ion Temperatures). Inasmuch as the outline is very skeletal, a significant research and development effort may be in order to evaluate these prospects in more detail and hopefully ''harness the H-bomb'' for peaceful applications, the author concludes. 28 references

  4. Confinement inertial fusion. Power reactors of nuclear fusion by lasers

    International Nuclear Information System (INIS)

    Velarde, G.; Ahnert, C.; Aragones, J.M.; Leira, G; Martinez-Val, J.M.

    1980-01-01

    The energy crisis and the need of the nuclear fusion energy are analized. The nuclear processes in the laser interation with the ablator material are studied, as well as the thermohydrodinamic processes in the implossion, and the neutronics of the fusion. The fusion reactor components are described and the economic and social impact of its introduction in the future energetic strategies.(author)

  5. Magnetic fusion reactor economics

    International Nuclear Information System (INIS)

    Krakowski, R.A.

    1995-01-01

    An almost primordial trend in the conversion and use of energy is an increased complexity and cost of conversion systems designed to utilize cheaper and more-abundant fuels; this trend is exemplified by the progression fossil fission → fusion. The present projections of the latter indicate that capital costs of the fusion ''burner'' far exceed any commensurate savings associated with the cheapest and most-abundant of fuels. These projections suggest competitive fusion power only if internal costs associate with the use of fossil or fission fuels emerge to make them either uneconomic, unacceptable, or both with respect to expensive fusion systems. This ''implementation-by-default'' plan for fusion is re-examined by identifying in general terms fusion power-plant embodiments that might compete favorably under conditions where internal costs (both economic and environmental) of fossil and/or fission are not as great as is needed to justify the contemporary vision for fusion power. Competitive fusion power in this context will require a significant broadening of an overly focused program to explore the physics and simbiotic technologies leading to more compact, simplified, and efficient plasma-confinement configurations that reside at the heart of an attractive fusion power plant

  6. Measuring the absolute DT neutron yield using the Magnetic Recoil Spectrometer at OMEGA and the NIF

    Energy Technology Data Exchange (ETDEWEB)

    Mackinnon, A; Casey, D; Frenje, J A; Johnson, M G; Seguin, F H; Li, C K; Petrasso, R D; Glebov, V Y; Katz, J; Knauer, J; Meyerhofer, D; Sangster, T; Bionta, R; Bleuel, D; Hachett, S P; Hartouni, E; Lepape, S; Mckernan, M; Moran, M; Yeamans, C

    2012-05-03

    A Magnetic Recoil Spectrometer (MRS) has been installed and extensively used on OMEGA and the National Ignition Facility (NIF) for measurements of the absolute neutron spectrum from inertial confinement fusion (ICF) implosions. From the neutron spectrum measured with the MRS, many critical implosion parameters are determined including the primary DT neutron yield, the ion temperature, and the down-scattered neutron yield. As the MRS detection efficiency is determined from first principles, the absolute DT neutron yield is obtained without cross-calibration to other techniques. The MRS primary DT neutron measurements at OMEGA and the NIF are shown to be in excellent agreement with previously established yield diagnostics on OMEGA, and with the newly commissioned nuclear activation diagnostics on the NIF.

  7. Industry's role in inertial fusion

    International Nuclear Information System (INIS)

    Glass, A.J.

    1983-01-01

    This paper is an address to the Tenth Symposium on Fusion Engineering. The speaker first addressed the subject of industry's role in inertial fusion three years earlier in 1980, outlining programs that included participation in the Shiva construction project, and the industrial participants' program set up in the laser fusion program to bring industrial scientists and engineers into the laboratory to work on laser fusion. The speaker is now the president of KMS Fusion, Inc., the primary industrial participant in the inertial fusion program. The outlook for fusion energy and the attitude of the federal government toward the fusion program is discussed

  8. Review of fusion synfuels

    International Nuclear Information System (INIS)

    Fillo, J.A.

    1980-01-01

    Thermonuclear fusion offers an inexhaustible source of energy for the production of hydrogen from water. Depending on design, electric generation efficiencies of approx. 40 to 60% and hydrogen production efficiencies by high-temperature electrolysis of approx. 50 to 65% are projected for fusion reactors using high-temperatures blankets. Fusion/coal symbiotic systems appear economically promising for the first generation of commercial fusion synfuels plants. Coal production requirements and the environmental effects of large-scale coal usage would be greatly reduced by a fusion/coal system. In the long term, there could be a gradual transition to an inexhaustible energy system based solely on fusion

  9. Design issues for a laboratory high gain fusion facility

    International Nuclear Information System (INIS)

    Hogan, W.J.

    1987-01-01

    In an inertial fusion laboratory high gain facility, experiments will be carried out with up to 1000 MJ of thermonuclear yield. The experiment area of such a facility will include many systems and structures that will have to operate successfully in the difficult environment created by the sudden large energy release. This paper estimates many of the nuclear effects that will occur, discusses the implied design issues and suggests possible solutions so that a useful experimental facility can be built. 4 figs

  10. Close collisions between light nuclei: Orbiting and fusion

    International Nuclear Information System (INIS)

    Shapira, D.; Shivakumar, B.; Harmon, B.A.; Ayik, S.

    1987-01-01

    Our data have demonstrated that in close collisions the two nuclei first form a rotating dinuclear complex (DNC) which can break up into two complex fragments (Orbiting) or evolve into a compound nucleus. The binary fragment yield was found to be significant in contradiction with earlier views which held that whenever nucleus-nucleus capture occurs fusion is a certainty. The time duration of the dinuclear stage and the nature of its evolution into a compound nucleus were studied and a model which describes these processes will be presented. 25 refs., 14 figs

  11. Novel neutralized-beam intense neutron source for fusion technology development

    International Nuclear Information System (INIS)

    Osher, J.E.; Perkins, L.J.

    1983-01-01

    We describe a neutralized-beam intense neutron source (NBINS) as a relevant application of fusion technology for the type of high-current ion sources and neutral beamlines now being developed for heating and fueling of magnetic-fusion-energy confinement systems. This near-term application would support parallel development of highly reliable steady-state higher-voltage neutral D 0 and T 0 beams and provide a relatively inexpensive source of fusion neutrons for materials testing at up to reactor-like wall conditions. Beam-target examples described incude a 50-A mixed D-T total (ions plus neutrals) space-charge-neutralized beam at 120 keV incident on a liquid Li drive-in target, or a 50-A T 0 + T + space-charge-neutralized beam incident on either a LiD or gas D 2 target with calculated 14-MeV neutron yields of 2 x 10 15 /s, 7 x 10 15 /s, or 1.6 x 10 16 /s, respectively. The severe local heat loading on the target surface is expected to limit the allowed beam focus and minimum target size to greater than or equal to 25 cm 2

  12. Fusion Canada issue 28

    International Nuclear Information System (INIS)

    1995-06-01

    A short bulletin from the National Fusion Program highlighting in this issue the Canada - US fusion meeting in Montreal, fusion breeder work in Chile, new management at CFFTP, fast electrons in tokamaks: new data from TdeV, a program review of CCFM and Velikhov to address Montreal fusion meeting. 1 fig

  13. Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Simon Imhof

    2016-04-01

    Full Text Available Diverse structures facilitate direct exchange of proteins between cells, including plasmadesmata in plants and tunnelling nanotubes in bacteria and higher eukaryotes.  Here we describe a new mechanism of protein transfer, flagellar membrane fusion, in the unicellular parasite Trypanosoma brucei. When fluorescently tagged trypanosomes were co-cultured, a small proportion of double-positive cells were observed. The formation of double-positive cells was dependent on the presence of extracellular calcium and was enhanced by placing cells in medium supplemented with fresh bovine serum. Time-lapse microscopy revealed that double-positive cells arose by bidirectional protein exchange in the absence of nuclear transfer.  Furthermore, super-resolution microscopy showed that this process occurred in ≤1 minute, the limit of temporal resolution in these experiments. Both cytoplasmic and membrane proteins could be transferred provided they gained access to the flagellum. Intriguingly, a component of the RNAi machinery (Argonaute was able to move between cells, raising the possibility that small interfering RNAs are transported as cargo. Transmission electron microscopy showed that shared flagella contained two axonemes and two paraflagellar rods bounded by a single membrane. In some cases flagellar fusion was partial and interactions between cells were transient. In other cases fusion occurred along the entire length of the flagellum, was stable for several hours and might be irreversible. Fusion did not appear to be deleterious for cell function: paired cells were motile and could give rise to progeny while fused. The motile flagella of unicellular organisms are related to the sensory cilia of higher eukaryotes, raising the possibility that protein transfer between cells via cilia or flagella occurs more widely in nature.

  14. Economics of fusion research

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1977-10-15

    This report provides the results of a study of methods of economic analysis applied to the evaluation of fusion research. The study recognizes that a hierarchy of economic analyses of research programs exists: standard benefit-cost analysis, expected value of R and D information, and expected utility analysis. It is shown that standard benefit-cost analysis, as commonly applied to research programs, is inadequate for the evaluation of a high technology research effort such as fusion research. A methodology for performing an expected value analysis is developed and demonstrated and an overview of an approach to perform an expected utility analysis of fusion research is presented. In addition, a potential benefit of fusion research, not previously identified, is discussed and rough estimates of its magnitude are presented. This benefit deals with the effect of a fusion research program on optimal fossil fuel consumption patterns. The results of this study indicate that it is both appropriate and possible to perform an expected value analysis of fusion research in order to assess the economics of a fusion research program. The results indicate further that the major area of benefits of fusion research is likely due to the impact of a fusion research program on optimal fossil fuel consumption patterns and it is recommended that this benefit be included in future assessments of fusion research economics.

  15. Economics of fusion research

    International Nuclear Information System (INIS)

    1977-01-01

    This report provides the results of a study of methods of economic analysis applied to the evaluation of fusion research. The study recognizes that a hierarchy of economic analyses of research programs exists: standard benefit-cost analysis, expected value of R and D information, and expected utility analysis. It is shown that standard benefit-cost analysis, as commonly applied to research programs, is inadequate for the evaluation of a high technology research effort such as fusion research. A methodology for performing an expected value analysis is developed and demonstrated and an overview of an approach to perform an expected utility analysis of fusion research is presented. In addition, a potential benefit of fusion research, not previously identified, is discussed and rough estimates of its magnitude are presented. This benefit deals with the effect of a fusion research program on optimal fossil fuel consumption patterns. The results of this study indicate that it is both appropriate and possible to perform an expected value analysis of fusion research in order to assess the economics of a fusion research program. The results indicate further that the major area of benefits of fusion research is likely due to the impact of a fusion research program on optimal fossil fuel consumption patterns and it is recommended that this benefit be included in future assessments of fusion research economics

  16. Inertial fusion energy

    International Nuclear Information System (INIS)

    Decroisette, M.; Andre, M.; Bayer, C.; Juraszek, D.; Le Garrec, B.; Deutsch, C.; Migus, A.

    2005-01-01

    We first recall the scientific basis of inertial fusion and then describe a generic fusion reactor with the different components: the driver, the fusion chamber, the material treatment unit, the target factory and the turbines. We analyse the options proposed at the present time for the driver and for target irradiation scheme giving the state of art for each approach. We conclude by the presentation of LMJ (laser Megajoule) and NIF (national ignition facility) projects. These facilities aim to demonstrate the feasibility of laboratory DT ignition, first step toward Inertial Fusion Energy. (authors)

  17. “Inclonals”: IgGs and IgG-enzyme fusion proteins produced in an E. coli expression-refolding system

    OpenAIRE

    Hakim, Rahely; Benhar, Itai

    2009-01-01

    Full-length antibodies and antibodies that ferry a cargo to target cells are desired biopharmaceuticals. We describe the production of full-length IgGs and IgG-toxin fusion proteins in E. coli. In the presented examples of anti CD30 and anti EGF-receptor antibodies, the antibody heavy and light chains or toxin fusions thereof were expressed in separate bacterial cultures, where they accumulated as insoluble inclusion bodies. Following refolding and purification, high yields (up to 50 mg/L of ...

  18. Monitoring of vibrating machinery using artificial neural networks

    International Nuclear Information System (INIS)

    Alguindigue, I.E.; Loskiewicz-Buczak, A.

    1991-01-01

    The primary source of vibration in complex engineering systems is rotating machinery. Vibration signatures collected from these components render valuable information about the operational state of the system and may be used to perform diagnostics. For example, the low frequency domain contains information about unbalance, misalignment, instability in journal bearing and mechanical looseness; analysis of the medium frequency range can render information about faults in meshing gear teeth; while the high frequency domain will contain information about incipient faults in rolling-element bearings. Trend analysis may be performed by comparing the vibration spectrum for each machine with a reference spectrum and evaluating the vibration magnitude changes at different frequencies. This form of analysis for diagnostics is often performed by maintenance personnel monitoring and recording transducer signals and analyzing the signals to identify the operating condition of the machine. With the advent of portable fast Fourier transform (FFT) analyzers and ''laptop'' computers, it is possible to collect and analyze vibration data an site and detect incipient failures several weeks or months before repair is necessary. It is often possible to estimate the remaining life of certain systems once a fault has been detected. RMS velocity, acceleration, displacements, peak value, and crest factor readings can be collected from vibration sensors. To exploit all the information embedded in these signals, a robust and advanced analysis technique is required. Our goal is to design a diagnostic system using neural network technology, a system such as this would automate the interpretation of vibration data coming from plant-wide machinery and permit efficient on-line monitoring of these components

  19. A comprehensive alpha-heating model for inertial confinement fusion

    Science.gov (United States)

    Christopherson, A. R.; Betti, R.; Bose, A.; Howard, J.; Woo, K. M.; Campbell, E. M.; Sanz, J.; Spears, B. K.

    2018-01-01

    A comprehensive model is developed to study alpha-heating in inertially confined plasmas. It describes the time evolution of a central low-density hot spot confined by a compressible shell, heated by fusion alphas, and cooled by radiation and thermal losses. The model includes the deceleration, stagnation, and burn phases of inertial confinement fusion implosions, and is valid for sub-ignited targets with ≤10 × amplification of the fusion yield from alpha-heating. The results of radiation-hydrodynamic simulations are used to derive realistic initial conditions and dimensionless parameters for the model. It is found that most of the alpha energy (˜90%) produced before bang time is deposited within the hot spot mass, while a small fraction (˜10%) drives mass ablation off the inner shell surface and its energy is recycled back into the hot spot. Of the bremsstrahlung radiation emission, ˜40% is deposited in the hot spot, ˜40% is recycled back in the hot spot by ablation off the shell, and ˜20% leaves the hot spot. We show here that the hot spot, shocked shell, and outer shell trajectories from this analytical model are in good agreement with simulations. A detailed discussion of the effect of alpha-heating on the hydrodynamics is also presented.

  20. Conceptual design and analysis of roads and road construction machinery for initial lunar base operations

    Science.gov (United States)

    Sines, Jeffrey L.; Banks, Joel; Efatpenah, Keyanoush

    1990-01-01

    Recent developments have made it possible for scientists and engineers to consider returning to the Moon to build a manned lunar base. The base can be used to conduct scientific research, develop new space technology, and utilize the natural resources of the Moon. Areas of the base will be separated, connected by a system of roads that reduce the power requirements of vehicles traveling on them. Feasible road types for the lunar surface were analyzed and a road construction system was designed for initial lunar base operations. A model was also constructed to show the system configuration and key operating features. The alternate designs for the lunar road construction system were developed in four stages: analyze and select a road type; determine operations and machinery needed to produce the road; develop machinery configurations; and develop alternates for several machine components. A compacted lunar soil road was selected for initial lunar base operations. The only machinery required to produce this road were a grader and a compactor. The road construction system consists of a main drive unit which is used for propulsion, a detachable grader assembly, and a towed compactor.

  1. The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles

    Directory of Open Access Journals (Sweden)

    Guillermo Bodega

    2017-01-01

    Full Text Available We examine the antioxidant role of young and senescent human umbilical vein endothelial cells (HUVECs and their microvesicles (MVs. Proteomic and Western blot studies have shown young HUVECs to have a complete and well-developed antioxidant system. Their MVs also contain antioxidant molecules, though of a smaller and more specific range, specialized in the degradation of hydrogen peroxide and the superoxide anion via the thioredoxin-peroxiredoxin system. Senescence was shown to be associated with a large increase in the size of the antioxidant machinery in both HUVECs and their MVs. These responses might help HUVECs and their MVs deal with the more oxidising conditions found in older cells. Functional analysis confirmed the antioxidant machinery of the MVs to be active and to increase in size with senescence. No glutathione or nonpeptide antioxidant (ascorbic acid and vitamin E activity was detected in the MVs. Endothelial cells and MVs seem to adapt to higher ROS concentrations in senescence by increasing their antioxidant machinery, although this is not enough to recover completely from the senescence-induced ROS increase. Moreover, MVs could be involved in the regulation of the blood plasma redox status by functioning as ROS scavengers.

  2. A sequential fuzzy diagnosis method for rotating machinery using ant colony optimization and possibility theory

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Hao; Ping, Xueliang; Cao, Yi; Lie, Ke [Jiangnan University, Wuxi (China); Chen, Peng [Mie University, Mie (Japan); Wang, Huaqing [Beijing University, Beijing (China)

    2014-04-15

    This study proposes a novel intelligent fault diagnosis method for rotating machinery using ant colony optimization (ACO) and possibility theory. The non-dimensional symptom parameters (NSPs) in the frequency domain are defined to reflect the features of the vibration signals measured in each state. A sensitive evaluation method for selecting good symptom parameters using principal component analysis (PCA) is proposed for detecting and distinguishing faults in rotating machinery. By using ACO clustering algorithm, the synthesizing symptom parameters (SSP) for condition diagnosis are obtained. A fuzzy diagnosis method using sequential inference and possibility theory is also proposed, by which the conditions of the machinery can be identified sequentially. Lastly, the proposed method is compared with a conventional neural networks (NN) method. Practical examples of diagnosis for a V-belt driving equipment used in a centrifugal fan are provided to verify the effectiveness of the proposed method. The results verify that the faults that often occur in V-belt driving equipment, such as a pulley defect state, a belt defect state and a belt looseness state, are effectively identified by the proposed method, while these faults are difficult to detect using conventional NN.

  3. Fusion in the energy system

    DEFF Research Database (Denmark)

    Fusion energy is the fundamental energy source of the Universe, as the energy of the Sun and the stars are produced by fusion of e.g. hydrogen to helium. Fusion energy research is a strongly international endeavor aiming at realizing fusion energy production in power plants on Earth. Reaching...... of integration into the future electricity system and socio-economic studies of fusion energy will be presented, referring to the programme of Socio-Economic Research on Fusion (SERF) under the European Fusion Energy Agreement (EFDA)....

  4. Membrane fusion and exocytosis.

    Science.gov (United States)

    Jahn, R; Südhof, T C

    1999-01-01

    Membrane fusion involves the merger of two phospholipid bilayers in an aqueous environment. In artificial lipid bilayers, fusion proceeds by means of defined transition states, including hourglass-shaped intermediates in which the proximal leaflets of the fusing membranes are merged whereas the distal leaflets are separate (fusion stalk), followed by the reversible opening of small aqueous fusion pores. Fusion of biological membranes requires the action of specific fusion proteins. Best understood are the viral fusion proteins that are responsible for merging the viral with the host cell membrane during infection. These proteins undergo spontaneous and dramatic conformational changes upon activation. In the case of the paradigmatic fusion proteins of the influenza virus and of the human immunodeficiency virus, an amphiphilic fusion peptide is inserted into the target membrane. The protein then reorients itself, thus forcing the fusing membranes together and inducing lipid mixing. Fusion of intracellular membranes in eukaryotic cells involves several protein families including SNAREs, Rab proteins, and Sec1/Munc-18 related proteins (SM-proteins). SNAREs form a novel superfamily of small and mostly membrane-anchored proteins that share a common motif of about 60 amino acids (SNARE motif). SNAREs reversibly assemble into tightly packed helical bundles, the core complexes. Assembly is thought to pull the fusing membranes closely together, thus inducing fusion. SM-proteins comprise a family of soluble proteins that bind to certain types of SNAREs and prevent the formation of core complexes. Rab proteins are GTPases that undergo highly regulated GTP-GDP cycles. In their GTP form, they interact with specific proteins, the effector proteins. Recent evidence suggests that Rab proteins function in the initial membrane contact connecting the fusing membranes but are not involved in the fusion reaction itself.

  5. Compact fusion reactors

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Fusion research is currently to a large extent focused on tokamak (ITER) and inertial confinement (NIF) research. In addition to these large international or national efforts there are private companies performing fusion research using much smaller devices than ITER or NIF. The attempt to achieve fusion energy production through relatively small and compact devices compared to tokamaks decreases the costs and building time of the reactors and this has allowed some private companies to enter the field, like EMC2, General Fusion, Helion Energy, Lawrenceville Plasma Physics and Lockheed Martin. Some of these companies are trying to demonstrate net energy production within the next few years. If they are successful their next step is to attempt to commercialize their technology. In this presentation an overview of compact fusion reactor concepts is given.

  6. Fusion research activities in China

    International Nuclear Information System (INIS)

    Deng Xiwen

    1998-01-01

    The fusion program in China has been executed in most areas of magnetic confinement fusion for more than 30 years. Basing on the situation of the power supply requirements of China, the fusion program is becoming an important and vital component of the nuclear power program in China. This paper reviews the status of fusion research and next step plans in China. The motivation and goal of the Chinese fusion program is explained. Research and development on tokamak physics and engineering in the southwestern institute of physics (SWIP) and the institute of plasma physics of Academic Sinica (ASIPP) are introduced. A fusion breeder program and a pure fusion reactor design program have been supported by the state science and technology commission (SSTC) and the China national nuclear corporation (CNNC), respectively. Some features and progress of fusion reactor R and D activities are reviewed. Non fusion applications of plasma science are an important part of China fusion research; a brief introduction about this area is given. Finally, an introductional collaboration network on fusion research activities in China is reported. (orig.)

  7. Industrial policy and technology diffusion : evidence from paper making machinery in Indonesia

    NARCIS (Netherlands)

    Dijk, van M.; Szirmai, A.

    2006-01-01

    In this paper, we analyze the diffusion and adoption of paper making machinery in the Indonesian pulp and paper industry, from 1923 till 2000. We develop a machine level index of technological sophistication (mach), which measures the technological distance of each paper machine to the world

  8. Cold fusion

    International Nuclear Information System (INIS)

    Suh, Suk Yong; Sung, Ki Woong; Kang, Joo Sang; Lee, Jong Jik

    1995-02-01

    So called 'cold fusion phenomena' are not confirmed yet. Excess heat generation is very delicate one. Neutron generation is most reliable results, however, the records are erratic and the same results could not be repeated. So there is no reason to exclude the malfunction of testing instruments. The same arguments arise in recording 4 He, 3 He, 3 H, which are not rich in quantity basically. An experiment where plenty of 4 He were recorded is attached in appendix. The problem is that we are trying to search cold fusion which is permitted by nature or not. The famous tunneling effect in quantum mechanics will answer it, however, the most fusion rate is known to be negligible. The focus of this project is on the theme that how to increase that negligible fusion rate. 6 figs, 4 tabs, 1512 refs. (Author)

  9. Applications of Skyrme energy-density functional to fusion reactions spanning the fusion barriers

    International Nuclear Information System (INIS)

    Liu Min; Wang, Ning; Li Zhuxia; Wu Xizhen; Zhao Enguang

    2006-01-01

    The Skyrme energy density functional has been applied to the study of heavy-ion fusion reactions. The barriers for fusion reactions are calculated by the Skyrme energy density functional with proton and neutron density distributions determined by using restricted density variational (RDV) method within the same energy density functional together with semi-classical approach known as the extended semi-classical Thomas-Fermi method. Based on the fusion barrier obtained, we propose a parametrization of the empirical barrier distribution to take into account the multi-dimensional character of real barrier and then apply it to calculate the fusion excitation functions in terms of barrier penetration concept. A large number of measured fusion excitation functions spanning the fusion barriers can be reproduced well. The competition between suppression and enhancement effects on sub-barrier fusion caused by neutron-shell-closure and excess neutron effects is studied

  10. Cold fusion research

    International Nuclear Information System (INIS)

    1989-11-01

    I am pleased to forward to you the Final Report of the Cold Fusion Panel. This report reviews the current status of cold fusion and includes major chapters on Calorimetry and Excess Heat, Fusion Products and Materials Characterization. In addition, the report makes a number of conclusions and recommendations, as requested by the Secretary of Energy

  11. Molecular dynamics simulations of interactions between hydrogen and fusion-relevant materials

    International Nuclear Information System (INIS)

    Rooij, Dagmar de

    2010-01-01

    In a thermonuclear reactor fusion between hydrogen isotopes takes place, producing helium and energy. The so-called divertor is the part of the fusion reactor vessel where the plasma is neutralized in order to exhaust the helium. The surface plates of the divertor are subjected to high heat loads and high fluxes of energetic hydrogen and helium. In the next generation fusion device - the tokamak ITER - the expected conditions at the plates are particle fluxes exceeding 10 24 per second and square metre, particle energies ranging from 1 to 100 eV and an average heat load of 10 MW per square metre. Two materials have been identified as candidates for the ITER divertor plates: carbon and tungsten. Since there are currently no fusion devices that can create these harsh conditions, it is unknown how the materials will behave in terms of erosion and hydrogen retention. To gain more insight in the physical processes under these conditions molecular dynamics simulations have been conducted. Since diamond has been proposed as possible plasma facing material, we have studied erosion and hydrogen retention in diamond and amorphous hydrogenated carbon (a-C:H). As in experiments, diamond shows a lower erosion yield than a-C:H, however the hydrogen retention in diamond is much larger than in a-C:H and also hardly depending on the substrate temperature. This implies that simple heating of the surface is not sufficient to retrieve the hydrogen from diamond material, whereas a-C:H readily releases the retained hydrogen. So, in spite of the higher erosion yield carbon material other than diamond seems more suitable. Experiments suggest that the erosion yield of carbon material decreases with increasing flux. This was studied in our simulations. The results show no flux dependency, suggesting that the observed reduction is not a material property but is caused by external factors as, for example, redeposition of the erosion products. Our study of the redeposition showed that the

  12. Characterization of Mason--Pfizer monkey virus-induced cell fusion

    International Nuclear Information System (INIS)

    Chatterjee, S.; Hunter, E.

    1979-01-01

    The characteristics and requirements of multinucleate cell (syncytium) induction by Mason--Pfizer monkey virus (M-PMV) on human and non-human primate cells have been investigated. Multinucleate cell induction by this D-type retrovirus shows single-hit kinetics on human foreskin and rhesus monkey fetal lung cells. The peak of syncytium-forming activity in an isopycnic sucrose gradient coincides with the peak of M-PMV virions as assessed by electron microscopy and analysis of viral polypeptides. Unlike the paramyxoviruses, M-PMV does not induce early cell fusion when added in high concentrations to the target cells. Furthermore, multinucleate cell formation is maximal 48 hr postinfection and the size of the syncytia remains constant after this time. Ultraviolet irradiation of M-PMV reduces its ability to form syncytia and to replicate with single-hit kinetics, suggesting that a functional viral genome is required for syncytium formation. Proviral DNA synthesis and assembly of virions are not necessary for cell fusion since the addition of cytosine arabinoside at concentrations which block virus replication has little effect on multinucleate cell formation. Moreover both multinucleate cells lacking detectable intracellular virus polypeptides, and groups of individual, nonfused but brightly staining cells can be observed in immunofluorescence assays at times when multinucleate cell formation is maximal. Cell fusion is inhibited by the addition of cycloheximide during the first 12 hr of infection, suggesting that de novo protein synthesis is required for multinucleate cell formation. The possibility that the translation of genomic RNA yields a fusion-inducing product is discussed

  13. InFusion: Advancing Discovery of Fusion Genes and Chimeric Transcripts from Deep RNA-Sequencing Data.

    Directory of Open Access Journals (Sweden)

    Konstantin Okonechnikov

    Full Text Available Analysis of fusion transcripts has become increasingly important due to their link with cancer development. Since high-throughput sequencing approaches survey fusion events exhaustively, several computational methods for the detection of gene fusions from RNA-seq data have been developed. This kind of analysis, however, is complicated by native trans-splicing events, the splicing-induced complexity of the transcriptome and biases and artefacts introduced in experiments and data analysis. There are a number of tools available for the detection of fusions from RNA-seq data; however, certain differences in specificity and sensitivity between commonly used approaches have been found. The ability to detect gene fusions of different types, including isoform fusions and fusions involving non-coding regions, has not been thoroughly studied yet. Here, we propose a novel computational toolkit called InFusion for fusion gene detection from RNA-seq data. InFusion introduces several unique features, such as discovery of fusions involving intergenic regions, and detection of anti-sense transcription in chimeric RNAs based on strand-specificity. Our approach demonstrates superior detection accuracy on simulated data and several public RNA-seq datasets. This improved performance was also evident when evaluating data from RNA deep-sequencing of two well-established prostate cancer cell lines. InFusion identified 26 novel fusion events that were validated in vitro, including alternatively spliced gene fusion isoforms and chimeric transcripts that include intergenic regions. The toolkit is freely available to download from http:/bitbucket.org/kokonech/infusion.

  14. Towards fusion power

    International Nuclear Information System (INIS)

    Venkataraman, G.

    1975-01-01

    An attempt has been made to present general but broad review of the recent developments in the field of plasma physics and its application to fusion power. The first chapter describes the fusion reactions and fusion power systems. The second chapter deals in detail with production and behaviour of plasma, screening, oscillations, instability, energy losses, temperature effects, etc. Magnetic confinements, including pinch systems, toroidal systems such as Tokamac and stellarator, minor machine, etc. are discussed in detail in chapter III. Laser produced plasma, laser implosion and problems associated with it and future prospects are explained in chapter IV. Chapter V is devoted entirely to the various aspects of hybrid systems. The last chapter throws light on problems of fusion technology, such as plasma heating, vacuum requirements, radiation damage, choice of materials, blanket problems, hazards of fusion reactions, etc. (K.B.)

  15. Neutron Generation by Laser-Driven Spherically Convergent Plasma Fusion

    Science.gov (United States)

    Ren, G.; Yan, J.; Liu, J.; Lan, K.; Chen, Y. H.; Huo, W. Y.; Fan, Z.; Zhang, X.; Zheng, J.; Chen, Z.; Jiang, W.; Chen, L.; Tang, Q.; Yuan, Z.; Wang, F.; Jiang, S.; Ding, Y.; Zhang, W.; He, X. T.

    2017-04-01

    We investigate a new laser-driven spherically convergent plasma fusion scheme (SCPF) that can produce thermonuclear neutrons stably and efficiently. In the SCPF scheme, laser beams of nanosecond pulse duration and 1 014- 1 015 W /cm2 intensity uniformly irradiate the fuel layer lined inside a spherical hohlraum. The fuel layer is ablated and heated to expand inwards. Eventually, the hot fuel plasmas converge, collide, merge, and stagnate at the central region, converting most of their kinetic energy to internal energy, forming a thermonuclear fusion fireball. With the assumptions of steady ablation and adiabatic expansion, we theoretically predict the neutron yield Yn to be related to the laser energy EL, the hohlraum radius Rh, and the pulse duration τ through a scaling law of Yn∝(EL/Rh1.2τ0.2 )2.5. We have done experiments at the ShengGuangIII-prototype facility to demonstrate the principle of the SCPF scheme. Some important implications are discussed.

  16. Industrial policy and technology diffusion : evidence from paper making machinery in Indonesia

    NARCIS (Netherlands)

    Dijk, van M.; Szirmai, A.

    2005-01-01

    In this paper, we analyse the diffusion and adoption of paper making machinery in the Indonesian pulp and paper industry, from 1923 till 2000. The two main questions in this paper are: (1) What patterns of technology diffusion can be discerned in the Indonesian paper manufacturing sector? (2) What

  17. 46 CFR 167.15-25 - Inspection standards for hulls, boilers and machinery.

    Science.gov (United States)

    2010-10-01

    ... SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Inspections § 167.15-25 Inspection standards for hulls, boilers and... 46 Shipping 7 2010-10-01 2010-10-01 false Inspection standards for hulls, boilers and machinery... inspection. These rules may be purchased from the American Bureau of Shipping (ABS), ABS Plaza, 16855...

  18. Transportation of part supply improvement in agricultural machinery assembly plant

    Science.gov (United States)

    Saysaman, Anusit; Chutima, Parames

    2018-02-01

    This research focused on the problem caused by the transportation of part supply in agricultural machinery assembly plant in Thailand, which is one of the processes that are critical to the whole production process. If poorly managed, it will affect transportation of part supply, the emergence of sink cost, quality problems, and the ability to respond to the needs of the customers in time. Since the competition in the agricultural machinery market is more intense, the efficiency of part transportation process has to be improved. In this study, the process of transporting parts of the plant was studied and it was found that the efficiency of the process of transporting parts from the sub assembly line to its main assembly line was 83%. The approach to the performance improvement is done by using the Lean tool to limit wastes based on the ECRS principle and applying pull production system by changing the transportation method to operate as milkrun for transportation of parts to synchronize with the part demands of the main assembly line. After the transportation of parts from sub-assembly line to the main assembly line was improved, the efficiency raised to 98% and transportation process cost was saved to 540,000 Baht per year.

  19. High-throughput deterministic single-cell encapsulation and droplet pairing, fusion, and shrinkage in a single microfluidic device

    NARCIS (Netherlands)

    Schoeman, R.M.; Kemna, Evelien; Wolbers, F.; van den Berg, Albert

    In this article, we present a microfluidic device capable of successive high-yield single-cell encapsulation in droplets, with additional droplet pairing, fusion, and shrinkage. Deterministic single-cell encapsulation is realized using Dean-coupled inertial ordering of cells in a Yin-Yang-shaped

  20. Heavy ion fusion

    International Nuclear Information System (INIS)

    Bangerter, R.O.

    1986-01-01

    This report on the International Symposium on Heavy Ion Fusion held May 27-29, 1986 summarizes the problems and achievements in the areas of targets, accelerators, focussing, reactor studies, and system studies. The symposium participants recognize that there are large uncertainties in Heavy Ion Fusion but many of them are also optimistic that HIF may ultimately be the best approach to fusion