First-time characterization of JY-1-like sequence in goats

African Journals Online (AJOL)

2015-07-11

Jul 11, 2015 ... Material and Methods. Nine well-recognized .... available, the bovine JY-1 gene sequence (GenBank accession no. .... Since no phenotypes on fecundity and sexual precocity are currently available for goats, it may not be ...

77 FR 64112 - Office of Energy Efficiency and Renewable Energy

Science.gov (United States)

2012-10-18

... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy Nationwide Categorical Waivers of the American Recovery and Reinvestment Act AGENCY: Office of Energy Efficiency and Renewable... Efficiency and Renewable Energy, U.S. Department of Energy. [FR Doc. 2012-25636 Filed 10-17-12; 8:45 am...

10 CFR 712.16 - DOE security review.

Science.gov (United States)

2010-01-01

... part. (c) Any mental/personality disorder or behavioral issues found in a personnel security file... 10 Energy 4 2010-01-01 2010-01-01 false DOE security review. 712.16 Section 712.16 Energy... Program Procedures § 712.16 DOE security review. (a) A personnel security specialist will perform a...

HAT-P-16b

DEFF Research Database (Denmark)

Buchhave, Lars A.; Bakos, G. A.; Hartman, J. D.

2010-01-01

We report the discovery of HAT-P-16b, a transiting extrasolar planet orbiting the V = 10.8 mag F8 dwarf GSC 2792-01700, with a period P = 2.775960 ± 0.000003 days, transit epoch Tc = 2455027.59293 ± 0.00031 (BJD10), and transit duration 0.1276 ± 0.0013 days. The host star has a mass of 1.22 ± 0.0...

Energy-related indoor environmental quality research: A priority agenda

Energy Technology Data Exchange (ETDEWEB)

Fisk, W.J.; Brager, G.; Burge, H.; Cummings, J.; Levin, H.; Loftness, V.; Mendell, M.J.; Persily, A.; Taylor, S.; Zhang, J.S.

2002-08-01

A multidisciplinary team of IEQ and energy researchers has defined a program of priority energy-related IEQ research. This paper describes the methods employed to develop the agenda, and 35 high priority research and development (R&D) project areas related to four broad goals: (1) identifying IEQ problems and opportunities; (2) developing and evaluating energy-efficient technologies for improving IEQ; (3) developing and evaluating energy-efficient practices for improving IEQ; and (4) encouraging or assisting the implementation of technologies or practices for improving IEQ. The identified R&D priorities reflect a strong need to benchmark IEQ conditions in small commercial buildings, schools, and residences. The R&D priorities also reflect the need to better understand how people are affected by IEQ conditions and by the related building characteristics and operation and maintenance practices. The associated research findings will provide a clearer definition of acceptable IEQ that is required to guide the development of technologies, practices, standards, and guidelines. Quantifying the effects of building characteristics and practices on IEQ conditions, in order to provide the basis for development of energy efficient and effective IEQ control measures, was also considered a priority. The development or advancement in a broad range of IEQ tools, technologies, and practices are also a major component of the priority research agenda. Consistent with the focus on ''energy-related'' research priorities, building ventilation and heating, ventilating and air conditioning (HVAC) systems and processes are very prominent in the agenda. Research related to moisture and microbiological problems, particularly within hot and humid climates, is also prominent within the agenda. The agenda tends to emphasize research on residences, small commercial buildings, and schools because these types of buildings have been underrepresented in prior research. Most of

Spectral intensity dependence an isotropy of sources stronger than 0.1 Jy at 2700 MHz

International Nuclear Information System (INIS)

Balonek, T.J.; Broderick, J.J.; Condon, J.J.; Crawford, D.F.; Jauncey, D.L.

1975-01-01

The 1000-foot (305 m) telescope of the National Astronomy and Ionosphere Center was used to measure 430 MHz flux densities of sources stronger than 0.1 Jy at 2700 MHz. Distributions of the resulting two-point spectral indices α (430, 2700) of sources in the intensity range 0.1less than or equal toS<0.35 Jy were compared with α (318, 2700) distributions of sources stronger than 0.35 Jy at 2700 MHz. The median normal-component spectral index and fraction of flat-spectrum sources in the faintest sample do not continue the previously discovered trend toward increased spectral steepening of faint sources. This result differs from the prediction of simple evolutionary cosmological models and therefore favors the alternative explanation that local source-density inhomogeneities are responsible for the observed intensity dependence of spectral indices

Study of the D(p,π+)T and 9Be(p,π+)10Be from 400 to 800MeV

International Nuclear Information System (INIS)

Aslanides, E.; Bauer, T.; Bertini, R.; Beurtey, R.; Bimbot, L.; Bing, O.; Boudard, A.; Brochard, F.; Bruge, G.; Catz, H.; Chaumeaux, A.; Couvert, P.; Duchazeaubeneix, J.C.; Duhm, H.; Garreta, D.; Gorodetzky, P.; Habault, J.; Hibou, F.; Igo, G.; Le Bornec, Y.; Lugol, J.C.; Matoba, M.; Tatischeff, B.; Terrien, Y.

Pion production on CD 2 and 9 Be targets has been observed using the high resolution, energy loss, spectrometer SPES I. Differential cross sections for the D(p,π + ) reaction have been determined at 410, 605 and 809MeV and for the 9 Be(p,π + ) reaction at 410 and 605MeV. The 3.37MeV (2 + ) state in 10 Be is populated preferentially, but a significant part of the transition strength seems to populate the ground state and the higher lying multiplets at about 6.1MeV, 7.4MeV and 9.4MeV [fr

10 CFR 16.15 - Procedures for internal salary offset.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Procedures for internal salary offset. 16.15 Section 16.15 Energy NUCLEAR REGULATORY COMMISSION SALARY OFFSET PROCEDURES FOR COLLECTING DEBTS OWED BY FEDERAL EMPLOYEES TO THE FEDERAL GOVERNMENT § 16.15 Procedures for internal salary offset. (a) Deductions to...

Priorities for energy efficiency measures in agriculture

NARCIS (Netherlands)

Visser, de C.L.M.

2013-01-01

This report provides research gaps and priorities for energy efficiency measures in agriculture across Europe, based on the analysis of the Coordination and Support Action AGREE (Agriculture & Energy Efficiency) funded by the 7th research framework of the EU (www.agree.aua.gr). The analysis from

Shell model description of 16O(p,γ)17F and 16O(p,p)16O reactions

International Nuclear Information System (INIS)

Bennaceur, K.; Michel, N.; Okolowicz, J.; Ploszajczak, M.; Bennaceur, K.; Nowacki, F.; Okolowicz, J.

2000-01-01

We present shell model calculations of both the structure of 17 F and the reactions 16 O(p,γ) 17 F, 16 O(p,p) 16 O. We use the ZBM interaction which provides a fair description of the properties of 16 O and neighbouring nuclei and, in particular it takes account for the complicated correlations in coexisting low-lying states of 16 O. (authors)

Percolation Analysis of a Wiener Reconstruction of the IRAS 1.2 Jy Redshift Catalog

Science.gov (United States)

Yess, Capp; Shandarin, Sergei F.; Fisher, Karl B.

1997-01-01

We present percolation analyses of Wiener reconstructions of the IRAS 1.2 Jy redshift survey. There are 10 reconstructions of galaxy density fields in real space spanning the range β = 0.1-1.0, where β = Ω0.6/b, Ω is the present dimensionless density, and b is the bias factor. Our method uses the growth of the largest cluster statistic to characterize the topology of a density field, where Gaussian randomized versions of the reconstructions are used as standards for analysis. For the reconstruction volume of radius R ~ 100 h-1 Mpc, percolation analysis reveals a slight ``meatball'' topology for the real space, galaxy distribution of the IRAS survey.

Treament Response in the neck: p16+ versus p16- oropharyngeal cancer

International Nuclear Information System (INIS)

Mak, Daisy; Hicks, Rodney J.; Rischin, Danny; Solomon, Ben; Peters, Lester; Corry, June; Bressel, Mathias; Young, Richard J.

2013-01-01

To compare nodal response rates following chemoradiotherapy in patients with p16+ and p16− oropharyngeal squamous cell carcinoma (OPSCC). Patients with node-positive OPSCC treated at Peter MacCallum Cancer Centre on the published phase I–III tirapazamine trials were identified. All patients had conventional assessment (clinical examination (CA), CT and/or MRI) and positron emission tomography (PET) at both baseline and 2–4 months post-treatment. There were 30 p16+ and 18 p16− patients, the former group having significantly higher stage nodal disease (P=0.016). The mean overall reduction in nodal size at post-treatment assessment was similar in p16+ and p16− patients (78% vs. 75%), and no statistically significant difference in nodal complete response (CR) rates was detected by either CA (50% vs. 39%, P=0.35) or PET/PET-CT (93% vs. 83%, P=0.19). PET was significantly more accurate in determining the true nodal CR rate in both groups, with a negative predictive value of 96%. Nodal response rates following chemoradiotherapy appear to be similar in p16+ and p16− patients when assessed by either CA or PET/PET-CT. However, higher nodal CR was seen in PET/PET-CT compared with CA in both groups. Metabolic imaging is more accurate than CA in assessing nodal response post-treatment.

Multi-source self-calibration: Unveiling the microJy population of compact radio sources

NARCIS (Netherlands)

Radcliffe, J. F.; Garrett, M. A.; Beswick, R. J.; Muxlow, T. W. B.; Barthel, P. D.; Deller, A. T.; Middelberg, E.

2016-01-01

Context. Very long baseline interferometry (VLBI) data are extremely sensitive to the phase stability of the VLBI array. This is especially important when we reach μJy rms sensitivities. Calibration using standard phase-referencing techniques is often used to improve the phase stability of VLBI

Transverse momentum dependence of the J/Ψ in the p-U, 16O-U and 32S-U interactions at 200 GeV/c per nucleon

International Nuclear Information System (INIS)

Drapier, O.

1990-05-01

We study in this thesis the transverse momentum dependence of dimuons produced with mass greated than 1.7 GeV/c 2 in p-U, 16 O-U and 32 S-U collisions at 200 GeV per nucleon. The NA38 experiment, performed at the CERN SPS, measures muon pairs produced in these collisions using the NA10 spectrometer. The neutral transverse energy, which is related to the centrality of the interaction, is deduced from the energy flow measured in an electromagnetic calorimeter located downstream an active target. Data are analysed with a method taking into account apparatus effects which are simulated through transfer matrices. The 16 O-U and 32 S-U results show that the T > and T 2 > values of J/Ψ dimuons increase with the measured neutral transverse energy and that such a correlation is not seen for the mass continuum dimuons. A comparison of these results with different models is presented. Results are first compared with quark-gluon plasma models which inhibits J/Ψ formation via a color screening effect. Models based on J/Ψ absorption in a dense hadron gas combined with parton multiple scattering in the entrance channel are also considered. Experimental data do not allow to distinguish between these different models [fr

76 FR 10583 - Priorities for Addressing Risks to the Reliability of the Bulk-Power System; Notice Establishing...

Science.gov (United States)

2011-02-25

... Addressing Risks to the Reliability of the Bulk- Power System; Notice Establishing Date for Comments On... regarding priorities for addressing risks to the reliability of the Bulk-Power System, as previously... Bulk-Power System, 76 FR 2369 (January 13, 2011), as supplemented by the Reliability Technical...

Energy distributions study of spallation neutrons produced at 0 deg. by proton beams (0.8 GeV and 1.6 GeV) and deuteron beams (1.2 and 1.6 GeV)

International Nuclear Information System (INIS)

Martinez, Eugenie

1997-01-01

We are studying the energy distributions of spallation neutrons produced at 0 deg. by protons of 0.8 GeV up to 1.6 GeV and deuterons of 1.2 and 1.6 GeV with two complementary experimental techniques: the time of flight measurement with tagged incident protons for low energy neutrons (3-400 MeV) and the use of a magnetic spectrometer at high energy (E ≥ 200 MeV). These measurements enable us to measure for the first time the neutron spectra for incident energies higher than 800 MeV. We have compared the double differential cross sections produced with 1.2 GeV protons on several thin targets (Al, Fe, Zr, W, Pb and Th). The neutron production obtained for a lead target is also studied for various energies (0.8 up to 1.6 GeV) and incident particles (p, d). Data are compared with theoretical simulations carried out using the TIERCE system and the intranuclear cascade model of J. Cugnon associated to the decay code of D. Durand. The neutron spectra calculated by using the HETC and MCNP codes, included in TIERCE, are significantly higher than the measured distributions. A better agreement is observed with the results of the Cugnon's cascade model. (author) [fr

Energy secretary's priorities include San Francisco area research projects

CERN Multimedia

Widener, A

2003-01-01

"Bay Area research labs got a big boost Monday when the Secretary of Energy unveiled his priorities for major research projects his agency hopes to fund over the next two decades. Among the agency's 28 top priorities are a major computer expansion and an experiment examining the expanding universe that could be housed at Lawrence Berkeley Lab and a powerful X-ray laser planned for the Stanford Linear Accelerator Center" (1 page).

Indirect Study of the 16O+16O Fusion Reaction Toward Stellar Energies by the Trojan Horse Method

Directory of Open Access Journals (Sweden)

Hayakawa S.

2016-01-01

Full Text Available The 16O+16O fusion reaction is important in terms of the explosive oxygen burning process during late evolution stage of massive stars as well as understanding of the mechanism of low-energy heavy-ion fusion reactions. We aim to determine the excitation function for the most major exit channels, α+28Si and p+31P, toward stellar energies indirectly by the Trojan Horse Method via the 16O(20Ne, α28Siα and 16O(20Ne, p31Pα three-body reactions. We report preliminary results involving reaction identification, and determination of the momentum distribution of α-16O intercluster motion in the projectile 20Ne nucleus.

Ethanol extract of Lycoris radiata induces cell death in B16F10 melanoma via p38-mediated AP-1 activation.

Science.gov (United States)

Son, Minsik; Kim, Aeyung; Lee, Jaewoo; Park, Chul-Hong; Heo, Jin-Chul; Lee, Hyun-Jin; Lee, Sang-Han

2010-08-01

Some active alkaloids isolated from Lycoris, a bulbous perennial herb, was shown to possess various anti-tumor and anti-inflammatory activities. In this study, we evaluated the in vitro apoptotic effect of ethanol extract from Lycoris radiata (LRE) and further probed the underlying molecular mechanisms of LRE effects. The survival rate of B16F10 melanoma cells exposed to LRE was decreased in a dose-dependent manner, cell growth was retarded by arresting cell cycle at G1 phase and apoptotic appearance such as caspase-3 activation as well as DNA fragmentation was observed by LRE treatment. In addition, LRE induced p38 and c-Jun phosphorylation, followed by activation of transcription factor AP-1. Pretreatment with the p38 inhibitor (SB203580) blocked LRE-induced AP-1 transcriptional activity, and curcumin, AP-1 inhibitor, dramatically inhibited LRE-induced apoptosis in B16F10 melanoma cells. Our results collectively indicate that LRE-mediated apoptosis occurs through the activation of p38 and AP-1 pathway and potentially LRE exhibits anti-cancer activity against B16F10 melanoma cells.

New Improved Indirect Measurement of the {sup 19}F( p , α ){sup 16}O Reaction at Energies of Astrophysical Relevance

Energy Technology Data Exchange (ETDEWEB)

Indelicato, I.; La Cognata, M.; Spitaleri, C.; Cherubini, S.; Gulino, M.; Lamia, L.; Pizzone, R. G.; Romano, S.; Tumino, A. [INFN, Laboratori Nazionali del Sud, Catania (Italy); Burjan, V.; Hons, Z.; Kroha, V.; Mrazek, J. [Nuclear Physics Institute of ASCR, Rez near Prague (Czech Republic); Hayakawa, S. [RIKEN, CNS, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Mazzocco, M.; Strano, E.; Torresi, D., E-mail: indelicato@lns.infn.it [INFN, Sezione di Padova, Padova (Italy)

2017-08-10

Fluorine abundance determination is of great importance in stellar physics to understand s-elements production and mixing processes in asymptotic giant branch (AGB) stars. Up to now, theoretical models overproduce F abundances in AGB stars with respect to the observed values, thus calling for further investigation of the reactions involving fluorine. In particular, the {sup 19}F( p , α ){sup 16}O reaction is the main destruction channel of fluorine at the bottom of the convective envelope in AGB stars, an H-rich environment where it can experience temperatures high enough to determine its destruction, owing to additional mixing processes. In this paper the Trojan horse method (THM) was used to extract the {sup 19}F( p , α {sub 0}){sup 16}O S-factor in the energy range of astrophysical interest ( E {sub cm} ≈ 0–1 MeV). This is the most relevant channel at the low temperatures (few 10{sup 7} K) characterizing the bottom of the convective envelope, according to current knowledge. A previous indirect experiment using the THM has observed three resonances in the energy regions below E {sub cm} ≈ 450 keV. These energies correspond to typical AGB temperatures, thus implying a significant increase in the reaction rate. Statistics are scarce for performing an accurate separation between resonances, preventing one from drawing a quantitative conclusion about their total widths and spin parities. Before THM measurement, only extrapolations were available below about 500 keV, showing a non-resonant behavior that sharply contradicts the trend of the astrophysical factor at higher energies. A new experiment has been performed to verify the measured TH astrophysical factor and to perform more accurate spectroscopy of the involved resonances.

Detection of neutrons of intermediate energy using 10B, enclosed in a coaxial Ge(Li) counter

International Nuclear Information System (INIS)

Huck, A.; Klotz, G.; Walter, G.

1976-01-01

A neutron detector operating in the energy range 1keV to roughly 1MeV with a time response that is fast enough to be used in time-of-flight experiments, has been designed and built. The neutron is absorbed in boron-10, placed inside a coaxial Ge(Li) counter. Efficient detection of the 478keV line from 7 Li, resulting from 10 B(n,α) 7 Li*, is realized. At the same time, the measurement of accompanying γ radiations, emitted by the neutron source, can be performed. Examples of results, obtained using (p,nγ) reactions, are given [fr

Atomic inner shell ionization: a new method of nuclear interaction lifetimes in the range 10-16-10-18 second. Lifetime measurement of the compound nucleus in the reaction 106Cd+p (Ep=10 and 12 MeV)

International Nuclear Information System (INIS)

Chemin, J.-F.

1978-01-01

A new method to measure the lifetime of the compound nucleus formed in the reaction 106 Cd+p at Ep=10 and 12 MeV is described. The nuclear lifetime is compared to the known lifetime of an atomic inner shell vacancy created in the entrance channel of the nuclear reaction. If the ionization probability in he way-in of the nuclear reaction is kown the compound nucleus lifetime is deduced by a simple relation from the number of compound X-rays measured in coincidence with one of the reaction products. A large number of ionization probability values measured in very small impact parameter collisions induced by H + , He + , D + on Al, Cu, S, Ti, Si, Ag, Cd are reported. The data are interpreted in terms of the corrected SCA theory of ionization. New effects such as angular dependence and trajectory effect (hair-pin-curve effect) are shown experimentally. The influence of a nuclear delay time on the ionization probability value is considered; the effect on a nuclear reaction of the energy losses by the projectile during the ionization process is analysed in detail. The yield curve of the resonant nuclear reaction 27 Al(p,γ) 28 Si is taken as an example. A detailed analysis of the compound nucleus 107 In lifetimes is given. Attention has been paid to competitive processes leading to X ray emission of same energy as the compound X rays. Extensions of the method to measure compound nucleus lifetimes in collision induced by heavy ions and to separate the shape elastic and compound elastic mechanisms are presented [fr

Immunohistochemical study of p53, pRb, p16 in esophageal cancer

International Nuclear Information System (INIS)

Zo, Jae Ill; Zo, Kyung Ja; Park, Jong Ho; Kim, Mi Hee

1998-01-01

To confirm the expression of molecular genetic alterations of p53, pRb, p16 in esophageal cancer and to investigate the expression of p53, pRb, p16 in esophageal cancer according to the pathologic steps of carcinogenesis, immuno-histochemistry was performed in 15 resected esophageal cancer specimens with multiple separated lesions after pathologic mapping. The accumulation of mutant p53 was observed in 60 % of dysplasia and 47 % of invasive cancer, while pRb was not detected in 91 % of dysplasia and 72.7 % of invasive cancer. But p16 was not observed in 0 % in dysplasia and 7 % of invasive cancer. But p16 was not observed in 0 % in dysplasia and 28.6 % in invasive cancer. There was no simultaneous negative pRb and p16 expression. There was no relations between p53 and p16, pRb. As a results, the expression of p53, pRb, p16 was co-related well with molecular genetic changes and inactivation of p53, pRb, p16 was co-related well with molecular genetic changes and inactivation of p53 and pRb was common and early event in esophageal carcinogenesis in Korea, but inactivation of p16 was a infrequent change. (author). 17 refs., 2 tabs., 7 figs

Reaction π+p → π+pπ0 (fast) at 16 GeV/c

International Nuclear Information System (INIS)

Ferguson, M.; Fortney, L.; Glanzman, T.

1980-01-01

An experiment at the SLAC bubble chamber hybrid facility including the lead glass shower detector is discussed. Early results from the reaction π + p → π + pπ 0 , with incident π + at 16 GeV, and π 0 energy > 8 GeV, are discussed

Reactor units for power supply to the Russian Arctic regions: Priority assessment of nuclear energy sources

Directory of Open Access Journals (Sweden)

Mel'nikov N. N.

2017-03-01

Full Text Available Under conditions of competitiveness of small nuclear power plants (SNPP and feasibility of their use to supply power to remote and inaccessible regions the competition occurs between nuclear energy sources, which is caused by a wide range of proposals for solving the problem of power supply to different consumers in the decentralized area of the Russian Arctic power complex. The paper suggests a methodological approach for expert assessment of the priority of small power reactor units based on the application of the point system. The priority types of the reactor units have been determined based on evaluation of the unit's conformity to the following criteria: the level of referentiality and readiness degree of reactor units to implementation; duration of the fuel cycle, which largely determines an autonomy level of the nuclear energy source; the possibility of creating a modular block structure of SNPP; the maximum weight of a transported single equipment for the reactor unit; service life of the main equipment. Within the proposed methodological approach the authors have performed a preliminary ranking of the reactor units according to various criteria, which allows quantitatively determining relative difference and priority of the small nuclear power plants projects aimed at energy supply to the Russian Arctic. To assess the sensitivity of the ranking results to the parameters of the point system the authors have observed the five-point and ten-point scales under variations of importance (weights of different criteria. The paper presents the results of preliminary ranking, which have allowed distinguishing the following types of the reactor units in order of their priority: ABV-6E (ABV-6M, "Uniterm" and SVBR-10 in the energy range up to 20 MW; RITM-200 (RITM-200M, KLT-40S and SVBR-100 in the energy range above 20 MW.

An Emergency Medicine Research Priority Setting Partnership to establish the top 10 research priorities in emergency medicine.

Science.gov (United States)

Smith, Jason; Keating, Liza; Flowerdew, Lynsey; O'Brien, Rachel; McIntyre, Sam; Morley, Richard; Carley, Simon

2017-07-01

Defining research priorities in a specialty as broad as emergency medicine is a significant challenge. In order to fund and complete the most important research projects, it is imperative that we identify topics that are important to all clinicians, society and to our patients. We have undertaken a priority setting partnership to establish the most important questions facing emergency medicine. The top 10 questions reached through a consensus process are discussed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

76 FR 63527 - National Energy Action Month, 2011

Science.gov (United States)

2011-10-12

... from the lab to the marketplace. If America can do what it does best--tap into the talents, skills, and.... (Presidential Sig.) [FR Doc. 2011-26560 Filed 10-11-11; 11:15 am] Billing code 3295-F2-P ...

The kidney cancer research priority-setting partnership: Identifying the top 10 research priorities as defined by patients, caregivers, and expert clinicians.

Science.gov (United States)

Jones, Jennifer; Bhatt, Jaimin; Avery, Jonathan; Laupacis, Andreas; Cowan, Katherine; Basappa, Naveen; Basiuk, Joan; Canil, Christina; Al-Asaaed, Sohaib; Heng, Daniel; Wood, Lori; Stacey, Dawn; Kollmannsberger, Christian; Jewett, Michael A S

2017-12-01

It is critically important to define disease-specific research priorities to better allocate limited resources. There is growing recognition of the value of involving patients and caregivers, as well as expert clinicians in this process. To our knowledge, this has not been done this way for kidney cancer. Using the transparent and inclusive process established by the James Lind Alliance, the Kidney Cancer Research Network of Canada (KCRNC) sponsored a collaborative consensus-based priority-setting partnership (PSP) to identify research priorities in the management of kidney cancer. The final result was identification of 10 research priorities for kidney cancer, which are discussed in the context of current initiatives and gaps in knowledge. This process provided a systematic and effective way to collaboratively establish research priorities with patients, caregivers, and clinicians, and provides a valuable resource for researchers and funding agencies.

Holographic dark energy and f(R) gravity

Energy Technology Data Exchange (ETDEWEB)

Aghamohammadi, A [Faculty of Science, Islamic Azad University of Sanandaj, Sanandaj (Iran, Islamic Republic of); Saaidi, Kh, E-mail: ksaaidi@uok.ac.ir, E-mail: agha35484@yahoo.com [Department of Physics, Faculty of Science, University of Kurdistan, Sanandaj (Iran, Islamic Republic of)

2011-02-15

We investigate the corresponding relation between f(R) gravity and holographic dark energy. We introduce a type of energy density from f(R) that has the same role as holographic dark energy. We obtain the differential equation that specifies the evolution of the introduced energy density parameter based on a varying gravitational constant. We discover the relation for the equation of state parameter for low redshifts that contains varying G correction.

Effect of selenium compounds on murine B16 melanoma cells and pigmented cloned pB16 cells

International Nuclear Information System (INIS)

Siwek, B.; Bahbouth, E.; Serra, M.A.; Sabbioni, E.; Pauw-Gillet, M.C. de; Bassleer, R.

1994-01-01

The effects of selenium compounds such as sodium selenite, sodium selenate, seleno-DL-cystine and seleno-DL-methionine (100 μM and 10 μM) on B16 and pigmented cloned pB 16 murine melanoma cells were investigated in vitro. At the tested concentrations, B16 cells showed a greater sensitivity to the toxic effects of sodium selenite and seleno-DL-cystine than pB 16 cells, whereas no decrease of B 16 and pB 16 cell number was observed after incubation with sodium selenate or seleno-DL-methionine. Glutathione (GSH) percentages were strongly decreased only by selenite and seleno-DL-cystine; it was marked more in B 16 than in pB 16 cells. The pretreatment of B 16 cells with a GSH depleting agent (10 μM buthionine-[S,R]-sulfoximine) did not significantly influence the cytotoxic effects of selenite and seleno-DL-cystine. On both cell populations. GSH preincubation (50 μM) enhanced the cytotoxicity of selenite whereas the survival of seleno-DL-cystine treated cells was increased. Glutathione peroxidase (GSH-Px) activity in B 16 cells was more sensitive than in pB 16 cells to the activating effect of selenite, and particularly of seleno-DL-cystine; however, cell-free controls indicated that activation was mainly due to glutathione reductase. The rate of 75 Se (as sodium selenite) uptake in both cell populations was maximal within the first hour of incubation, with a preferential accumulation in the cytosol; after 24 h of incubation, the amount of 75 Se in cytosol and pellet was approximately the same. Gel filtration chromatography of lysed cells after incubation for 6 h with 10 μM 75 Se-selenite showed that the radioactivity was eluted as two peaks corresponding to low (4-9 kDa) and high (280-320 kDa) molecular weights. Possible toxicological mechanisms are discussed at molecular level. (orig./MG)

High CpG island methylation of p16 gene and loss of p16 protein ...

Indian Academy of Sciences (India)

The study subjects consisted of 75 healthy ... that p16 protein expression was significantly lower in ToF group compared to ... in p16 promoters in ToF patients was negatively correlated with p16 protein ... studies, human foetal ventricular cardiomyocytes (HFCs) are ..... oral epithelial dysplasia: a prospective cohort study.

High CpG island methylation of p16 gene and loss of p16 protein

Indian Academy of Sciences (India)

Methylation-specific polymerase chain reaction (MSP) was employed to detect CpG island methylation in p16 promoter region andWestern blotting was used to detect p16 expression of all subjects. Real-time fluorescence quantitative polymerase chain reaction (FQ-PCR) was performed to test p16 mRNA expression.

Nuclear microanalysis of 16O and 18O in near-surface regions of solids. Applications

International Nuclear Information System (INIS)

Amsel, G.

The best suited nuclear technique for 18 O analysis is the direct observation of nuclear reactions. Here, instead of measuring an induced radioactivity, one observes the particles emitted as a result of the O 18 (p,α)N 15 reaction. The α particles which are produced may be detected with surface barrier semiconductor detectors; they present unit detection efficiency and allow one to realize large solid angles of detection, while their energy resolution is excellent. For getting O 18 /O 16 ratios, 16 O must also be measured. This is achieved in a similar way, using the O 16 (d,p) 17 O reaction [fr

Stability evaluation of occlusal changes obtained with Fränkel's Function Regulator-2

Directory of Open Access Journals (Sweden)

Tânia Gnecchi Tanaka

2012-12-01

Full Text Available OBJECTIVE: To analyze the stability of occlusal changes promoted by the Frankel's Functional Regulator 2 (FR-2, in a mean period of 7.16 years post treatment. METHODS: Fifty-four pairs of models were evaluated, from 18 patients treated with FR-2. All patients had Class II, division 1 malocclusion, with initial mean age of 10.77 years and were treated with FR-2 for 18 months. The models were evaluated at the beginning of treatment (T1, at the end (T2 and after 7.16 years post treatment (T3. For occlusal evaluation, the treatment priority index (TPI was applied on the three analyzed phases. The alterations that occurred between phases were verified with one another through paired Student's t test, with critical value of 0.05. RESULTS: A statistically significant reduction of TPI was verified, from the initial to the final phase of the treatment, reflecting the efficiency of treatment performed with FR-2, specially due to improvement in molar relation, overjet and overbite. Apart from this, the Class II correction remained stable over time. CONCLUSIONS: In this way, it is concluded that the FR-2 appliance showed to be efficient for the dental correction of Class II malocclusion, with stable occlusal results after 7.16 years post treatment.OBJETIVO: analisar a estabilidade das alterações oclusais promovidas pelo aparelho Regulador de Função Fränkel-2 (RF-2, num período médio de 7,16 anos pós-tratamento. MÉTODOS: foram avaliados 54 pares de modelos, provenientes de 18 pacientes tratados por meio do aparelho RF-2. Todos os pacientes possuíam má oclusão de Classe II, divisão 1, com idade inicial média de 10,77 anos e foram tratados com o RF-2 por 18 meses. Os modelos foram avaliados no início do tratamento (T1, no final do tratamento (T2 e decorridos 7,16 anos pós-tratamento ativo (T3. Para a avaliação oclusal, aplicou-se o Índice de Prioridade de Tratamento (IPT nas três fases analisadas. As alterações ocorridas entre as fases

78 FR 24192 - J.P. Morgan Ventures Energy Corp. v. Midwest Independent System Operator, Inc. PJM...

Science.gov (United States)

2013-04-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL13-58-000] J.P. Morgan Ventures Energy Corp. v. Midwest Independent System Operator, Inc. PJM Interconnection, L.L.C.; Notice of Complaint Take notice that on April 10, 2013, J.P. Morgan Ventures Energy Corporation (JPMVEC or Complainant...

(16) {C}16C-elastic scattering examined using several models at different energies

Science.gov (United States)

El-hammamy, M. N.; Attia, A.

2018-05-01

In the present paper, the first results concerning the theoretical analysis of the ^{16}C + p reaction by investigating two elastic scattering angular distributions measured at high energy compared to low energy for this system are reported. Several models for the real part of the nuclear potential are tested within the optical model formalism. The imaginary potential has a Woods-Saxon shape with three free parameters. Two types of density distribution and three different cluster structures for ^{16}C are assumed in the analysis. The results are compared with each other as well as with the experimental data to give evidence of the importance of these studied items.

10 CFR 470.16 - Cost sharing and funds from other sources.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Cost sharing and funds from other sources. 470.16 Section... § 470.16 Cost sharing and funds from other sources. Proposers are encouraged to offer to share in the... other entities to obtain supplemental funding. ...

Deep 3 GHz number counts from a P(D) fluctuation analysis

Science.gov (United States)

Vernstrom, T.; Scott, Douglas; Wall, J. V.; Condon, J. J.; Cotton, W. D.; Fomalont, E. B.; Kellermann, K. I.; Miller, N.; Perley, R. A.

2014-05-01

Radio source counts constrain galaxy populations and evolution, as well as the global star formation history. However, there is considerable disagreement among the published 1.4-GHz source counts below 100 μJy. Here, we present a statistical method for estimating the μJy and even sub-μJy source count using new deep wide-band 3-GHz data in the Lockman Hole from the Karl G. Jansky Very Large Array. We analysed the confusion amplitude distribution P(D), which provides a fresh approach in the form of a more robust model, with a comprehensive error analysis. We tested this method on a large-scale simulation, incorporating clustering and finite source sizes. We discuss in detail our statistical methods for fitting using Markov chain Monte Carlo, handling correlations, and systematic errors from the use of wide-band radio interferometric data. We demonstrated that the source count can be constrained down to 50 nJy, a factor of 20 below the rms confusion. We found the differential source count near 10 μJy to have a slope of -1.7, decreasing to about -1.4 at fainter flux densities. At 3 GHz, the rms confusion in an 8-arcsec full width at half-maximum beam is ˜ 1.2 μJy beam-1, and a radio background temperature ˜14 mK. Our counts are broadly consistent with published evolutionary models. With these results, we were also able to constrain the peak of the Euclidean normalized differential source count of any possible new radio populations that would contribute to the cosmic radio background down to 50 nJy.

75 FR 69334 - International Product and Price Changes

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2010-11-12

... illustrate Global Express Guaranteed and Express Mail International permit imprints.] [GRAPHIC] [TIFF OMITTED.... Priority Mail Gift Card Flat Rate Priority Mail DVD Box, 7\\9/ Envelope, 10'' x 7'', Item EP 14-GT. 16\\'' x... appropriate Price Group table based on the prices below:] BILLING CODE P [[Page 69340

Energy efficiency in Serbia national energy efficiency program: Strategy and priorities for the future

Directory of Open Access Journals (Sweden)

Oka Simeon

2006-01-01

Full Text Available Energy system in Serbia, in the whole energy chain, from exploitation of primary energy sources, transformations in electric power plants and district heating plants, energy (electric and heat transmission and distribution to final users, and up to final energy consumption, is faced with a number of irrational and inefficient behavior and processes. In order to fight with such situation National Energy Efficiency Program, financed by the Ministry of Science and Environmental Protection has been founded in 2001. Basic facts about status of energy sector in Serbia, with special emphasis on the energy efficiency and use of renewable energy sources have been given in the review paper published in the issue No. 2, 2006 of this journal. In present paper new strategy and priorities of the National Energy Efficiency Program for the future period from 2006 to 2008, and beyond, is presented. This strategy and priorities are mainly based on the same concept and principles as previous, but new reality and new and more simulative economic and financial environment in energy sector made by the Energy low (accepted by Parliament in 2004 and Strategy of Development of Energy Sector in Republic Serbia up to 2015 (accepted by the Parliament in May 2005, have been taken into account. Also, responsibilities that are formulated in the Energy Community Treaty signed by the South-East European countries, and also coming from documents and directives of the European Community and Kyoto Protocol are included in new strategy. Once again necessity of legislative framework and influence of regulations and standards, as well as of the governmental support, has been pointed out if increased energy efficiency and increased use of renewable energy sources are expected. .

Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population.

Science.gov (United States)

Yu, H; Yan, H; Li, J; Li, Z; Zhang, X; Ma, Y; Mei, L; Liu, C; Cai, L; Wang, Q; Zhang, F; Iwata, N; Ikeda, M; Wang, L; Lu, T; Li, M; Xu, H; Wu, X; Liu, B; Yang, J; Li, K; Lv, L; Ma, X; Wang, C; Li, L; Yang, F; Jiang, T; Shi, Y; Li, T; Zhang, D; Yue, W

2017-07-01

Many schizophrenia susceptibility loci have been identified through genome-wide association studies (GWASs) in European populations. However, until recently, schizophrenia GWASs in non-European populations were limited to small sample sizes and have yielded few loci associated with schizophrenia. To identify genetic risk variations for schizophrenia in the Han Chinese population, we performed a two-stage GWAS of schizophrenia comprising 4384 cases and 5770 controls, followed by independent replications of 13 single-nucleotide polymorphisms in an additional 4339 schizophrenia cases and 7043 controls of Han Chinese ancestry. Furthermore, we conducted additional analyses based on the results in the discovery stage. The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 × 10 -12 , odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 × 10 -10 , OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 × 10 -10 , OR=0.87; rs10883765 at an intron of ARL3, P=3.06 × 10 -9 , OR=0.87). The polygenic risk score based on Psychiatric Genomics Consortium schizophrenia GWAS data modestly predicted case-control status in the Chinese population (Nagelkerke R 2 : 1.7% ~5.7%). Our pathway analysis suggested that neurological biological pathways such as GABAergic signaling, dopaminergic signaling, cell adhesion molecules and myelination pathways are involved in schizophrenia. These findings provide new insights into the pathogenesis of schizophrenia in the Han Chinese population. Further studies are needed to establish the biological context and potential clinical utility of these findings.

10 CFR 609.16 - Perfection of liens and preservation of collateral.

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2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Perfection of liens and preservation of collateral. 609.16... THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.16 Perfection of liens and preservation of collateral. (a... to perfect and maintain liens, as applicable, on assets which are pledged as collateral for the...

Spitzer deep and wide legacy mid- and far-infrared number counts and lower limits of cosmic infrared background

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Béthermin, M.; Dole, H.; Beelen, A.; Aussel, H.

2010-03-01

Aims: We aim to place stronger lower limits on the cosmic infrared background (CIB) brightness at 24 μm, 70 μm and 160 μm and measure the extragalactic number counts at these wavelengths in a homogeneous way from various surveys. Methods: Using Spitzer legacy data over 53.6 deg2 of various depths, we build catalogs with the same extraction method at each wavelength. Completeness and photometric accuracy are estimated with Monte-Carlo simulations. Number count uncertainties are estimated with a counts-in-cells moment method to take galaxy clustering into account. Furthermore, we use a stacking analysis to estimate number counts of sources not detected at 70 μm and 160 μm. This method is validated by simulations. The integration of the number counts gives new CIB lower limits. Results: Number counts reach 35 μJy, 3.5 mJy and 40 mJy at 24 μm, 70 μm, and 160 μm, respectively. We reach deeper flux densities of 0.38 mJy at 70, and 3.1 at 160 μm with a stacking analysis. We confirm the number count turnover at 24 μm and 70 μm, and observe it for the first time at 160 μm at about 20 mJy, together with a power-law behavior below 10 mJy. These mid- and far-infrared counts: 1) are homogeneously built by combining fields of different depths and sizes, providing a legacy over about three orders of magnitude in flux density; 2) are the deepest to date at 70 μm and 160 μm; 3) agree with previously published results in the common measured flux density range; 4) globally agree with the Lagache et al. (2004) model, except at 160 μm, where the model slightly overestimates the counts around 20 and 200 mJy. Conclusions: These counts are integrated to estimate new CIB firm lower limits of 2.29-0.09+0.09 nW m-2 sr-1, 5.4-0.4+0.4 nW m-2 sr-1, and 8.9-1.1+1.1 nW m-2 sr-1 at 24 μm, 70 μm, and 160 μm, respectively, and extrapolated to give new estimates of the CIB due to galaxies of 2.86-0.16+0.19 nW m-2 sr-1, 6.6-0.6+0.7 nW m-2 sr-1, and 14.6-2.9+7.1 nW m-2 sr-1

Setting the top 10 research priorities to improve the health of people with Type 2 diabetes: a Diabetes UK-James Lind Alliance Priority Setting Partnership.

Science.gov (United States)

Finer, S; Robb, P; Cowan, K; Daly, A; Shah, K; Farmer, A

2018-07-01

To describe processes and outcomes of a priority setting partnership to identify the 'top 10 research priorities' in Type 2 diabetes, involving people living with the condition, their carers, and healthcare professionals. We followed the four-step James Lind Alliance Priority Setting Partnership process which involved: gathering uncertainties using a questionnaire survey distributed to 70 000 people living with Type 2 diabetes and their carers, and healthcare professionals; organizing the uncertainties; interim priority setting by resampling of participants with a second survey; and final priority setting in an independent group of participants, using the nominal group technique. At each step the steering group closely monitored and guided the process. In the first survey, 8227 uncertainties were proposed by 2587 participants, of whom 18% were from black, Asian and minority ethnic groups. Uncertainties were formatted and collated into 114 indicative questions. A total of 1506 people contributed to a second survey, generating a shortlist of 24 questions equally weighted to the contributions of people living with diabetes and their carers and those of healthcare professionals. In the final step the 'top 10 research priorities' were selected, including questions on cure and reversal, risk identification and prevention, and self-management approaches in Type 2 diabetes. Systematic and transparent methodology was used to identify research priorities in a large and genuine partnership of people with lived and professional experience of Type 2 diabetes. The top 10 questions represent consensus areas of research priority to guide future research, deliver responsive and strategic allocation of research resources, and improve the future health and well-being of people living with, and at risk of, Type 2 diabetes. © 2018 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.

Analysis of human papilloma virus in oral squamous cell carcinoma using p16: An immunohistochemical study

Science.gov (United States)

Patil, S.; Rao, R. S.; Amrutha, N.; Sanketh, D. S.

2014-01-01

Aims: The aim of this study is to evaluate the expression of human papilloma virus (HPV) in oral squamous cell carcinoma (OSCC) and to correlate the association of HPV in histological grades of OSCC using p16 (p16INK4a) immunohistochemistry (IHC). Subjects and Methods: This study consists of 30 histological diagnosed cases of OSCC (10-well-differentiated oral squamous cell carcinoma [WDOSCC], 10-moderately differentiated oral squamous cell carcinoma [MDOSCC] and 10-poorly differentiated oral squamous cell carcinoma [PDOSCC]). The sections were subjected to IHC procedure using p16. Two parameters in immunohistochemical p16 expression were evaluated by 3 observers based on the criteria by Galgano M. Tetal (2010) (a) percentage of p16 positive cases (b) pattern of p16 staining in various grades of OSCC. Statistical Analysis Used: Kappa test. Results: Totally, 30 samples of 0SCC, p16 positivity was noted in 26/30 (86.66%). Of 26 positive cases, p16 staining was positive in 7/10 (70%) of WDOSCC, 9/10 (90%) in MDOSCC and, 10/10 (100%) PDOSCC. Incidentally, we also found single dispersed cell staining in WDOSCC, patchy staining in MDOSCC and more diffuse staining pattern predominant in PDOSCC. Conclusions: Our study revealed an association between HPV and OSCC. Diffuse staining pattern was noted in PDOSCC, which in turn depicts the increase viral overload, which might have an influence on its aggressive behavior. PMID:24818098

The fluorine destruction in stars: First experimental study of the 19F(p,α)16O reaction at astrophysical energies

International Nuclear Information System (INIS)

La Cognata, M.; Mukhamedzhanov, A.; Spitaleri, C.; Indelicato, I.; Aliotta, M.; Burjan, V.; Cherubini, S.; Coc, A.; Gulino, M.; Hons, Z.; Kiss, G. G.; Kroha, V.; Lamia, L.; Mrazek, J.; Palmerini, S.; Piskor, S.; Pizzone, R. G.; Puglia, S. M. R.; Rapisarda, G. G.; Romano, S.

2012-01-01

The 19 F(p,α) 16 O reaction is an important fluorine destruction channel in the proton-rich outer layers of asymptotic giant branch (AGB) stars and it might also play a role in hydrogendeficient post-AGB star nucleosynthesis. So far, available direct measurements do not reach the energy region of astrophysical interest (E cm ∼ 300 keV), because of the hindrance effect of the Coulomb barrier. The Trojan Horse (TH) method was thus used to access this energy region, by extracting the quasi-free contribution to the 2 H( 19 F,α 16 O)n reaction. The TH measurement of the α 0 channel, which is the dominant one at such energies, shows the presence of resonant structures not observed before that cause an increase of the reaction rate at astrophysical temperatures up to a factor of 1.7, with potential important consequences for stellar nucleosynthesis.

Shifting policy priorities in EU-China energy relations: Implications for Chinese energy investments in Europe

International Nuclear Information System (INIS)

Gippner, Olivia; Torney, Diarmuid

2017-01-01

Shifting energy policy priorities both in China and the EU (European Union) have transformed their bilateral relationship. In order to assess the impact of domestic policy priorities on bilateral energy cooperation and climate policy, this comparative study traces the evolution of EU and Chinese approaches to energy policy – and their relative emphasis on factors and frames such as availability, efficiency, affordability and environmental stewardship. Drawing on government documents and a data set of interviews with Chinese policy-makers, experts and academics in 2015–2016, the article argues that while the EU started with a strong emphasis on environmental stewardship and moved towards a focus on affordability and availability, China started with a strong emphasis on availability and has moved towards a greater emphasis on environmental stewardship. This shift in frames on the Chinese side and subsequent changes in subsidy structures and targets can partially explain the increase in investments in renewable energy technologies. The article concludes that the Chinese and EU perspectives have become more aligned over the past ten years, coinciding with an increasing trend towards renewable energy in Chinese energy investments in the EU, for example in Italy and the UK. - Highlights: • Compares dominant frames of energy policy in China and the European Union in the period 2005–2015. • Shows that there has been a convergence of policy frames between China and the EU. • Convergence on environmental stewardship is necessary but not sufficient for FDI in clean energy.

Expression of cdk4 and p16 in Oral Lichen Planus.

Science.gov (United States)

Goel, Sinny; Khurana, Nita; Marwah, Akanksha; Gupta, Sunita

2015-01-01

The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with normal mucosa and oral squamous cell carcinoma. Analysis of cdk4 and p16 expression was done in 43 erosive oral lichen planus (EOLP) and 17 non-erosive oral lichen planus (NOLP) cases, 10 normal mucosa and 10 oral squamous cell carcinoma (OSCC) cases with immunohistochemistry. This study demonstrated a significantly increased expression of cytoplasmic cdk4 (80% cases, cells stained - 19.6%), and cytoplasmic p16 (68.3% cases, cells stained - 16.4%) in oral lichen planus (OLP) compared to normal mucosa. cdk4 was much higher in OSCC in both cytoplasm and nuclei compared to normal mucosa. Also, while comparing OLP with positive control, significant difference was noted for cdk4 and p16, with expression being more in OSCC. While comparing EOLP with NOLP; significant differences were seen for cdk4 cytoplasmic staining only, for number of cases with positive staining as well as number of cells stained. Overexpression of cytoplasmic cdk4 and p16 was registered in oral lichen planus, however considerably lower than in squamous cell carcinoma. Erosive oral lichen planus demonstrated overexpression of cytoplasmic cdk4 and premalignant nature compared to non-erosive lesion. Therefore there is an obvious possibility for cytoplasmic expression of cdk4 and p16 to predict malignant potential of oral lichen planus lesions.

Meiotic and pedigree segregation analyses in carriers of t(4;8)(p16;p23.1) differing in localization of breakpoint positions at 4p subband 4p16.3 and 4p16.1.

Science.gov (United States)

Midro, Alina T; Zollino, Marcella; Wiland, Ewa; Panasiuk, Barbara; Iwanowski, Piotr S; Murdolo, Marina; Śmigiel, Robert; Sąsiadek, Maria; Pilch, Jacek; Kurpisz, Maciej

2016-02-01

The purpose of this study was to compare meiotic segregation in sperm cells from two carriers with t(4;8)(p16;p23.1) reciprocal chromosome translocations (RCTs), differing in localization of the breakpoint positions at the 4p subband-namely, 4p16.3 (carrier 1) and 4p16.1 (carrier 2)-and to compare data of the pedigree analyses performed by direct method. Three-color fluorescent in situ hybridization (FISH) on sperm cells and FISH mapping for the evaluation of the breakpoint positions, data from pedigrees, and direct segregation analysis of the pedigrees were performed. Similar proportions of normal/balanced and unbalanced sperm cells were found in both carriers. The most common was an alternate type of segregation (about 52 % and about 48 %, respectively). Unbalanced adjacent I and adjacent II karyotypes were found in similar proportions about 15 %. The direct segregation analysis (following Stengel-Rutkowski) of the pedigree of carriers of t(4;8)(p16.1;p23.1) was performed and results were compared with the data of the pedigree segregation analysis obtained earlier through the indirect method. The probability of live-born progeny with unbalanced karyotype for carriers of t(4;8)(p16.1;p23.1) was moderately high at 18.8 %-comparable to the value obtained using the indirect method for the same carriership, which was 12 %. This was, however, markedly lower than the value of 41.2 % obtained through the pedigree segregation indirect analysis estimated for carriers of t(4;8)(p16.3;p23.1), perhaps due to the unique composition of genes present within the 4p16.1-4p 16.3 region. Revealed differences in pedigree segregation analysis did not correspond to the very similar profile of meiotic segregation patterns presented by carrier 1 and carrier 2. Most probably, such discordances may be due to differences in embryo survival rates arising from different genetic backgrounds.

RD & D priorities for energy production and resource conservation from municipal solid waste

Energy Technology Data Exchange (ETDEWEB)

1992-08-01

This report identifies research, development, and demonstration (RD&D) needs and priorities associated with municipal solid waste (MSW) management technologies that conserve or produce energy or resources. The changing character of MSW waste management and the public`s heightened awareness of its real and perceived benefits and costs creates opportunities for RD&D in MSW technologies. Increased recycling, for example, creates new opportunities for energy, chemicals, and materials recovery. New technologies to control and monitor emissions from MSW combustion facilities are available for further improvement or application. Furthermore, emerging waste-to-energy technologies may offer environmental, economic, and other advantages. Given these developments, DOE identified a need to assess the RD&D needs and pdodties and carefully target RD&D efforts to help solve the carbon`s waste management problem and further the National Energy Strategy. This report presents such an assessment. It identifies and Documents RD&D needs and priorities in the broad area of MSW resource . recovery, focusing on efforts to make MSW management technologies commercially viable or to improve their commercial deployment over a 5 to l0 year period. Panels of technical experts identifies 279 RD&D needs in 12 technology areas, ranking about one-fifth of these needs as priorities. A ``Peer Review Group`` identified mass-burn combustion, ``systems studies,`` landfill gas, and ash utilization and disposal as high priority areas for RD&D based on cost and the impacts of further RD&D. The results of this assessment are intended to provide guidance to DOE concerning possible future RD&D projects.

SINTESIS 4,10,16,22-TETRAMETOKSIKALIKS[4] ARENA DARI MINYAK ADAS (SYNTHESIS OF 4,10,16,22-TETRAMETHOXYCALIX [4] ARENE FROM ANISE OIL

Directory of Open Access Journals (Sweden)

Ratna Ningsih S

2015-01-01

Full Text Available One kind of calixarenes, i.e. 4,10,16,22-tetramethoxycalix[4]arene (4, has been synthesized from anethole (1, which was isolated from anise oil. The synthesis of 4 was carried out via acid-catalyzed procedure. The reaction route consists of three stages, i.e. (i oxidation of 1 with KMnO4 at 40oC for 15 minutes, (ii reduction p-anisaldehyde (2 with NaBH4 at 76oC for 3 hours, and  (iii cyclotetramerization of p-anisilalcohol (3 with AlCl3 at 20oC for 2 hours. Oxidation of 1 produced 2 in 77%, whereas reduction of 2 gave 3 in 55 %. The cyclotetramerization of 3 yielded 4 in 95 %.  Key Words: 4,10,16,22-tetramethoxycalix[4]arene, Anise Oil, Anethole

A common 16p11.2 inversion underlies the joint susceptibility to asthma and obesity.

Science.gov (United States)

González, Juan R; Cáceres, Alejandro; Esko, Tonu; Cuscó, Ivon; Puig, Marta; Esnaola, Mikel; Reina, Judith; Siroux, Valerie; Bouzigon, Emmanuelle; Nadif, Rachel; Reinmaa, Eva; Milani, Lili; Bustamante, Mariona; Jarvis, Deborah; Antó, Josep M; Sunyer, Jordi; Demenais, Florence; Kogevinas, Manolis; Metspalu, Andres; Cáceres, Mario; Pérez-Jurado, Luis A

2014-03-06

The prevalence of asthma and obesity is increasing worldwide, and obesity is a well-documented risk factor for asthma. The mechanisms underlying this association and parallel time trends remain largely unknown but genetic factors may be involved. Here, we report on a common ~0.45 Mb genomic inversion at 16p11.2 that can be accurately genotyped via SNP array data. We show that the inversion allele protects against the joint occurrence of asthma and obesity in five large independent studies (combined sample size of 317 cases and 543 controls drawn from a total of 5,809 samples; combined OR = 0.48, p = 5.5 × 10(-6)). Allele frequencies show remarkable worldwide population stratification, ranging from 10% in East Africa to 49% in Northern Europe, consistent with discordant and extreme genetic drifts or adaptive selections after human migration out of Africa. Inversion alleles strongly correlate with expression levels of neighboring genes, especially TUFM (p = 3.0 × 10(-40)) that encodes a mitochondrial protein regulator of energy balance and inhibitor of type 1 interferon, and other candidates for asthma (IL27) and obesity (APOB48R and SH2B1). Therefore, by affecting gene expression, the ~0.45 Mb 16p11.2 inversion provides a genetic basis for the joint susceptibility to asthma and obesity, with a population attributable risk of 39.7%. Differential mitochondrial function and basal energy balance of inversion alleles might also underlie the potential selection signature that led to their uneven distribution in world populations. Copyright © 2014 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Trisomy 10p and translocation of 10q to 4p associated with selective dysgenesis of IgA-producing cells in lymphoid tissue.

Science.gov (United States)

Saiga, Tatsuyoshi; Hashimoto, Kazuhiro; Kimura, Nobusuke; Ono, Hisako; Hiai, Hiroshi

2007-01-01

A combined chromosomal abberation trisomy of the short arm of chromosome 10 associated with translocation of 10q to chromosome 4p was found in a 14-month-old boy, who died after repeated bouts of pneumonia. The translocation involved the target region 4p16.3 of Wolf-Hirschhorn syndrome and/or Pitt-Rogers-Danks syndrome. The karyotype was 46,XY,der(4)t(4;10)(p16;q11.2),i(10)(p10),ish der(4)t(4;10)(p16.3;q11.2) (D4S96+,D4Z1+),i(10) (pter ++). In addition to growth retardation and external as well as internal dysmorphism, the patient had abnormalities of the immune system, such as thymic involution, generalized lymph node enlargement, unusual distribution of T cells in lymphoid follicles, and selective IgA deficiency. The IgA-producing cells were rarely found in lymph nodes but normally in intestinal mucosa. In contrast, in the lymph nodes, the paracortical T-lymphocytes were hyperplastic, but they rarely entered the primary follicles. It is assumed that the chromosomal abnormality may lead to the dysfunction of T lymphocytes and, further, to the dysgenesis of IgA-producing cells in lymph nodes but not in intestinal mucosa. This suggests that the thymus may differentially control the subsets of IgA-producing cells in lymph nodes and intestinal mucosa.

Poor energy poor: Energy saving obligations, distributional effects, and the malfunction of the priority group

International Nuclear Information System (INIS)

Moser, Simon

2013-01-01

The European Union’s Energy Efficiency Directive forces the Member States to install energy efficiency obligation schemes. In a first step, this paper identifies the distributional effects caused by this policy instrument which occur when energy efficiency measures are implemented (phase of delivery) and when its costs are passed on to the society (phase of financing). In the phase of delivery, suppliers prefer to implement measures at the property of those customers which enable them to minimise their costs, i.e. enterprises with large energy savings potentials and high-income households who can contribute a greater share of the costs. In the phase of financing, distributional effects occur when the costs of the scheme are passed on from the obliged suppliers to their customers, primarily affecting less competitive customers, i.e. households and small enterprises. In the British scheme, the so-called priority group was installed in order to decrease distributional effects and to support energy poor households. In a second step, this paper evaluates approaches to reduce energy poverty and indicates ineffectiveness, high transaction costs and incoherency with the aims of the obligation scheme. Alternative approaches to tackle energy poverty are briefly described. - Highlights: • The paper discusses distributional effects of energy efficiency obligations. • Significant distributional effects occur when measures are implemented. • Significant distributional effects occur when costs are passed on to the customers. • Suppliers face problems to identify energy poor households. • The priority group contradicts the scheme’s intention of cost minimisation

Thermonuclear 19F(p, {{\\boldsymbol{\\alpha }}}_{0})16O reaction rate

Science.gov (United States)

He, Jian-Jun; Lombardo, Ivano; Dell'Aquila, Daniele; Xu, Yi; Zhang, Li-Yong; Liu, Wei-Ping

2018-01-01

The thermonuclear 19F(p, {{{α }}}0)16O reaction rate in the temperature region 0.007-10 GK has been derived by re-evaluating the available experimental data, together with the low-energy theoretical R-matrix extrapolations. Our new rate deviates by up to about 30% compared to the previous results, although all rates are consistent within the uncertainties. At very low temperature (e.g. 0.01 GK) our reaction rate is about 20% lower than the most recently published rate, because of a difference in the low energy extrapolated S-factor and a more accurate estimate of the reduced mass used in the calculation of the reaction rate. At temperatures above ˜1 GK, our rate is lower, for instance, by about 20% around 1.75 GK, because we have re-evaluated the previous data (Isoya et al., Nucl. Phys. 7, 116 (1958)) in a meticulous way. The present interpretation is supported by the direct experimental data. The uncertainties of the present evaluated rate are estimated to be about 20% in the temperature region below 0.2 GK, and are mainly caused by the lack of low-energy experimental data and the large uncertainties in the existing data. Asymptotic giant branch (AGB) stars evolve at temperatures below 0.2 GK, where the 19F(p, {{α }})16O reaction may play a very important role. However, the current accuracy of the reaction rate is insufficient to help to describe, in a careful way, the fluorine over-abundances observed in AGB stars. Precise cross section (or S factor) data in the low energy region are therefore needed for astrophysical nucleosynthesis studies. Supported by National Natural Science Foundation of China (11490562, 11490560, 11675229) and National Key Research and Development Program of China (2016YFA0400503)

The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouse

Directory of Open Access Journals (Sweden)

Bayrak Aykut

2003-05-01

Full Text Available Abstract Background Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs. CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs. Method In this study we tested the expression of CDKIs p15, p16, p21 and p27 by immunohistochemistry to determine the role of CDKIs in the initiation of primordial follicle growth. Ovaries were collected from 60-day-old cycling B6D2F1/J mice (n = 16. Results Expression of p15, p16, p21 and p27 did not vary in granulosa and theca cells by the follicle stage. However, p16 staining was stronger (++ in the oocytes of all primordial, and 57.4 ± 3.1% of primary follicles compared to the remaining primary and more advanced follicles (+. Interestingly, primary follicles with weaker (+ oocyte staining for p16 had significantly larger mean follicle diameter compared to the primary and primordial follicles with stronger (++ oocyte staining (55.6 ± 2.1 vs. 32.0 ± 1.0 and 26.5 ± 0.7 μm, respectively, p Conclusions These preliminary findings suggest that the initiation of oocyte growth, which seems to lead follicle growth, is associated with diminished p16 expression in the mouse ovary. Further studies are needed to investigate the factors that regulate the expression of p16 in the oocyte, which might also govern the initiation of primordial follicle growth.

76 FR 21879 - Energy Conservation Program for Consumer Products: Decision and Order Granting a Waiver to LG...

Science.gov (United States)

2011-04-19

... granted waivers to Electrolux (76 FR 11440 (March 2, 2011)) and Samsung (76 FR 13169 (March 10, 2011... granted to Whirlpool, GE, Samsung and Electrolux, as well as previously to LG, the clothes washer test... make representations about the energy use of its clothes washer products for compliance, marketing, or...

Academic training lectures | The outlook for energy supply and demand | 14 - 16 September

CERN Multimedia

2015-01-01

Please note that the next series of Academic Training Lectures will take place on the 14, 15 and 16 September. The lectures will be given by by Chris Llewellyn Smith (Director of Energy Research, University of Oxford, President of SESAME Council). The Outlook for Energy Supply and Demand (1/3) on Monday, 14 September from 11.00 a.m. to 12.00 p.m. https://indico.cern.ch/event/388334/ Can Future Energy Needs be Met Sustainably? (2/3) on Tuesday, 15 September from 4.30 p.m. to 5.30 p.m.  (CERN Colloquium) https://indico.cern.ch/event/388335/ The Outlook for Energy Supply and Demand (3/3) on Wednesday, 16 September from 11.00 a.m to 12.00 p.m. https://indico.cern.ch/event/388336/ at CERN, Main Auditorium, in Building 500-1-001. Description: These lectures will review the challenges facing energy policy, the outlook for different sources of primary energy (fossil and renewable), how energy is used, and prospects for improved energy efficiency. A colloquium ‘Can Future Energy Needs be Met ...

46 CFR 90.10-16 - Industrial vessel.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Industrial vessel. 90.10-16 Section 90.10-16 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 90.10-16 Industrial vessel. This term means every vessel which by reason of its special outfit, purpose, design, or function engages in certain industrial...

Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation

Directory of Open Access Journals (Sweden)

You Chul Chung

2017-10-01

Full Text Available Tyrosinase is the rate-limiting enzyme critical for melanin synthesis. It controls pigmentation in the skin. Activation of tyrosinase is currently the most common approach in the development of tanning and haircare products. Pratol is a 7-hydroxy-4-methoxyflavone found in Trifolium pratense. In this study, we investigated the effects of pratol on melanogenesis. We also studied the mechanism of action of pratol in B16F10 mouse melanoma cells. The cells were treated with various concentrations (6.25, 12.5, 25, and 50 μM of pratol to observe its effects. The results showed that pratol significantly increased melanin content and tyrosinase activity in the cells without being cytotoxic. In addition, pratol strongly increased the expression of tyrosinase and tyrosinase-related protein-1 and 2 by enhancing the expression of microphthalmia-associated transcription factor. Furthermore, pratol stimulated melanogenesis via the phosphorylation of p38, c-Jun N-terminal kinases (JNK, and extracellular signal–regulated kinase (ERK. The findings from an assay searching for the inhibitor revealed that SB203580 (a specific p38 inhibitor or SP600125 (a p-JNK inhibitor attenuated pratol-induced cellular tyrosinase activity whereas PD98059 (an ERK inhibitor did not. Additionally, pratol interfered with the phosphorylation of p-AKT. We also found that pratol-induced melanogenesis was reversed by H89, which is a specific protein kinase A inhibitor. The results suggest that, owing to its multi-functional properties, pratol may be a potential tanning agent or a therapeutic agent for hair depigmentation in the cosmetic industry.

The Topology of Large-Scale Structure in the 1.2 Jy IRAS Redshift Survey

Science.gov (United States)

Protogeros, Zacharias A. M.; Weinberg, David H.

1997-11-01

We measure the topology (genus) of isodensity contour surfaces in volume-limited subsets of the 1.2 Jy IRAS redshift survey, for smoothing scales λ = 4, 7, and 12 h-1 Mpc. At 12 h-1 Mpc, the observed genus curve has a symmetric form similar to that predicted for a Gaussian random field. At the shorter smoothing lengths, the observed genus curve shows a modest shift in the direction of an isolated cluster or ``meatball'' topology. We use mock catalogs drawn from cosmological N-body simulations to investigate the systematic biases that affect topology measurements in samples of this size and to determine the full covariance matrix of the expected random errors. We incorporate the error correlations into our evaluations of theoretical models, obtaining both frequentist assessments of absolute goodness of fit and Bayesian assessments of models' relative likelihoods. We compare the observed topology of the 1.2 Jy survey to the predictions of dynamically evolved, unbiased, gravitational instability models that have Gaussian initial conditions. The model with an n = -1 power-law initial power spectrum achieves the best overall agreement with the data, though models with a low-density cold dark matter power spectrum and an n = 0 power-law spectrum are also consistent. The observed topology is inconsistent with an initially Gaussian model that has n = -2, and it is strongly inconsistent with a Voronoi foam model, which has a non-Gaussian, bubble topology.

High CpG island methylation of p16 gene and loss of p16 protein ...

Indian Academy of Sciences (India)

SI-JU GAO

The study subjects consisted of 75 healthy controls and 63 ToF ... Additionally, our analysis suggested that CpG island methylation in p16 promoters in ToF ..... reduced p16 protein expression in lung cancer (Kondo et al. 2006). In this context ..... promoter methylation in gastric carcinogenesis: a meta-analysis. Mol. Biol. Rep.

Top 10 research priorities in head and neck cancer: Results of an Alberta priority setting partnership of patients, caregivers, family members, and clinicians.

Science.gov (United States)

Lechelt, Leah A; Rieger, Jana M; Cowan, Katherine; Debenham, Brock J; Krewski, Bernie; Nayar, Suresh; Regunathan, Akhila; Seikaly, Hadi; Singh, Ameeta E; Laupacis, Andreas

2018-03-01

The epidemiology, etiology, and management of head and neck cancer are evolving. Understanding the perspectives and priorities of nonresearchers regarding treatment uncertainties is important to inform future research. Using the James Lind Alliance approach, patients, caregivers, and clinicians responded to a survey regarding their unanswered questions about treating and managing head and neck cancer. Distinct uncertainties were extracted from responses and sorted into themes. Uncertainties already answered in the literature were removed. Those remaining were ranked by patients and clinicians to develop a short list of priorities, which were discussed at a workshop and reduced to the top 10. One hundred sixty-one respondents posed 818 uncertainties, culminating in 77 for interim ranking and 27 for discussion at a workshop. Participants reached consensus on the top 10, which included questions on prevention, screening, treatment, and quality of life. Nonresearchers can effectively collaborate to establish priorities for future research in head and neck cancer. © 2017 Wiley Periodicals, Inc.

76 FR 79666 - Decision and Order Granting a Waiver to LG from the Department of Energy Residential Clothes...

Science.gov (United States)

2011-12-22

..., 2011)) and Samsung (76 FR 13169 (Mar. 10, 2011); 76 FR 50207 (Aug. 12, 2011)). DOE notes that its... was submitted by LG, the waivers granted to Whirlpool, GE, Samsung and Electrolux, as well as... may make representations about the energy use of its clothes washer products for compliance, marketing...

Investigation of low spin resonances in the 12C+12C and 16O+12C systems

International Nuclear Information System (INIS)

Uzureau, J.L.; Fieni, J.M.; Cocu, F.; Michaudon, A.

1979-01-01

The excitation functions of the 12 C( 12 C,α) 20 Ne and 12 C( 16 O,α) 24 Mg reactions were measured at different angles below the Coulomb barrier. Resonant structures were found at Esub(cm)=5.80 MeV in the 12 C+ 12 C system and at Esub(cm)=6.10 MeV in the 16 O+ 12 C system. From the analysis of angular distributions measured at the previous resonant energies, values of respectively Jsup(π)=0 + and 2 + have been deduced [fr

75 FR 39680 - Houston Pipe Line Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid...

Science.gov (United States)

2010-07-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-44-000; Docket No. PR10-46-000; Docket No. PR10-48- 000; Docket No. PR10-49-000; Docket No. PR10-50-000] Houston Pipe Line Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid Continent Market Center, L.L.C...

Contraband detection using high-energy gamma rays from 16O*

International Nuclear Information System (INIS)

Micklich, B.J.; Fink, C.L.; Sagalovsky, L.; Smith, D.L.

1996-01-01

High-energy monoenergetic gamma rays (6.13 and 7.12 MeV) from the decay of excited states of the 16 O* nucleus are highly penetrating and thus offer potential for non-intrusive inspection of loaded containers for narcotics, explosives, and other contraband items. These excited states can be produced by irradiation of water with 14-MeV neutrons from a DT neutron generator or through the 19 F(p,α) 16 O* reaction. Resonances in 19 F(p,α) 16 O* at proton energies between 340 keV and 2 MeV allow use of a low-energy accelerator to provide a compact, portable gamma source of reasonable intensity. The present work provides estimates of gamma source parameters and suggests how various types of contraband could be detected. Gamma rays can be used to perform transmission or emission radiography of containers or other objects. Through the use of (γ, n) and (γ, fission) reactions, this technique is also capable of detecting special nuclear materials such as deuterium, lithium, beryllium, uranium, and plutonium. Analytic and Monte Carlo techniques are used to model empty and loaded container inspection for accelerator-produced gamma, radioisotope, and x-ray sources

HAT-P-16b: A Bayesian Atmospheric Retrieval

Science.gov (United States)

McIntyre, Kathleen; Harrington, Joseph; Blecic, Jasmina; Cubillos, Patricio; Challener, Ryan; Bakos, Gaspar

2017-10-01

HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). We observed two secondary eclipses of HAT-P-16b using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to produce normalized eclipse light curves, and our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the planet. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Balancing energy, development and climate priorities in India. Current trends and future projections

International Nuclear Information System (INIS)

Shukla, P.R.; Garg, A.; Dhar, S.; Halsnaes, K.

2007-09-01

This report gives a short introduction to the project: Projecting future energy demand: Balancing development, energy and climate priorities in large developing countries. Furthermore, the report analyses Indian energy, development and climate change, followed by an assessment of cross-country results that gives a range of key indicators of the relationship between economic growth, energy, and local and global pollutants. The focus is on the energy sector policies that mainstream climate interests within development choices. (BA)

A de-novo interstitial microduplication involving 2p16.1-p15 and mirroring 2p16.1-p15 microdeletion syndrome: Clinical and molecular analysis.

Science.gov (United States)

Mimouni-Bloch, Aviva; Yeshaya, Josepha; Kahana, Sarit; Maya, Idit; Basel-Vanagaite, Lina

2015-11-01

Microdeletions of various sizes in the 2p16.1-p15 chromosomal region have been grouped together under the 2p16.1-p15 microdeletion syndrome. Children with this syndrome generally share certain features including microcephaly, developmental delay, facial dysmorphism, urogenital and skeletal abnormalities. We present a child with a de-novo interstitial 1665 kb duplication of 2p16.1-p15. Clinical features of this child are distinct from those of children with the 2p16.1-p15 microdeletion syndrome, specifically the head circumference which is within the normal range and mild intellectual disability with absence of autistic behaviors. Microduplications many times bear milder clinical phenotypes in comparison with corresponding microdeletion syndromes. Indeed, as compared to the microdeletion syndrome patients, the 2p16.1-p15 microduplication seems to have a milder cognitive effect and no effect on other body systems. Limited information available in genetic databases about cases with overlapping duplications indicates that they all have abnormal developmental phenotypes. The involvement of genes in this location including BCL11A, USP34 and PEX13, affecting fundamental developmental processes both within and outside the nervous system may explain the clinical features of the individual described in this report. Copyright © 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

The role of human papillomavirus in p16-positive oral cancers.

Science.gov (United States)

Belobrov, Simone; Cornall, Alyssa M; Young, Richard J; Koo, Kendrick; Angel, Christopher; Wiesenfeld, David; Rischin, Danny; Garland, Suzanne M; McCullough, Michael

2018-01-01

The aim of this study was to identify the presence and frequency of human papillomavirus (HPV) nucleic acid in p16-positive oral squamous cell carcinomas (OSCCs), to assess whether the virus was transcriptionally active and to assess the utility of p16 overexpression as a surrogate marker for HPV in OSCC. Forty-six OSCC patients treated between 2007 and 2011 with available formalin-fixed paraffin-embedded (FFPE) specimens were included. Twenty-three patients were positive for p16 by immunohistochemistry (IHC) and these were matched with 23 patients with p16-negative tumours. Laser capture microdissection of the FFPE OSCC tissues was undertaken to isolate invasive tumour tissue. DNA was extracted and tested for high-risk HPV types using a PCR-ELISA method based on the L1 SPF10 consensus primers, and a real-time PCR method targeting HPV-16 and HPV-18 E6 region. Genotyping of HPV-positive cases was performed using a reverse line blot hybridization assay (Inno-LiPA). RNAScope ® (a chromogenic RNA in situ hybridization assay) was utilized to detect E6/E7 mRNA of known high-risk HPV types for detection of transcriptionally active virus. HPV DNA was found in 3 OSCC cases, all of which were p16 IHC-positive. Two cases were genotyped as HPV-16 and one as HPV-33. Only one of the HPV-16 cases was confirmed to harbour transcriptionally active virus via HPV RNA ISH. We have shown that the presence of transcriptionally active HPV rarely occurs in OSCC and that p16 is not an appropriate surrogate marker for HPV in OSCC cases. We propose that non-viral mechanisms are responsible for the majority of IHC p16 overexpression in OSCC. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Identifying conservation priorities and management strategies based on ecosystem services to improve urban sustainability in Harbin, China.

Science.gov (United States)

Qu, Yi; Lu, Ming

2018-01-01

Rapid urbanization and agricultural development has resulted in the degradation of ecosystems, while also negatively impacting ecosystem services (ES) and urban sustainability. Identifying conservation priorities for ES and applying reasonable management strategies have been found to be effective methods for mitigating this phenomenon. The purpose of this study is to propose a comprehensive framework for identifying ES conservation priorities and associated management strategies for these planning areas. First, we incorporated 10 ES indicators within a systematic conservation planning (SCP) methodology in order to identify ES conservation priorities with high irreplaceability values based on conservation target goals associated with the potential distribution of ES indicators. Next, we assessed the efficiency of the ES conservation priorities for meeting the designated conservation target goals. Finally, ES conservation priorities were clustered into groups using a K-means clustering analysis in an effort to identify the dominant ES per location before formulating management strategies. We effectively identified 12 ES priorities to best represent conservation target goals for the ES indicators. These 12 priorities had a total areal coverage of 13,364 km 2 representing 25.16% of the study area. The 12 priorities were further clustered into five significantly different groups ( p -values between groups urban and agricultural areas, thereby preventing urban and agriculture sprawl and guiding sustainable urban development.

Assessment of energy research, development, and demonstration priorities for New York State. Interim report. Volume I

Energy Technology Data Exchange (ETDEWEB)

Allentuck, J; Appleman, J; Carroll, T O; Palmedo, P F; Nathans, R

1977-11-01

In compliance with its mandate to accelerate the development and use of energy technologies in furtherance of the state's economic growth and the best interests of its population, the New York State Energy Research and Development Authority (NYSERDA) initiated, in March 1977, an assessment of energy research and development priorities. This report presents a view of the energy supply-demand future of the state, and the ways in which this future can be affected by external contingencies and concerted policies. That view takes into consideration energy supplies that may be available to the state as well as energy demands as they are affected by demographic and economic changes within the state. Also included are the effects of national energy policies and technological developments as they modify both supplies and demands in New York State. Finally, this report proceeds to identify those general technological areas in which the Authority's program can be of greatest potential benefit to the state's social and economic well being. This effort aims at a cost/benefit analysis determination of RD and D priorities. The preliminary analysis thus far indicates these areas as being of highest priority: energy conservation in buildings (promotion and execution of RD and D) and industry; district heating; fuel cell demonstration;solar heating and cooling (analysis, demonstration, and information dissemination); energy-environment interaction (analysis); energy information services; and, in general, the attraction of Federal RD and D programs to the state.

Implementation of 16% renewable energy in 2020; Invulling van 16% hernieuwbare energie in 2020

Energy Technology Data Exchange (ETDEWEB)

Winkel, T.; De Visser, E. [Ecofys, Utrecht (Netherlands); Lensink, S. [ECN Beleidsstudies, Petten (Netherlands)

2013-05-15

The first part deals with the numerical implementation of the 16% target: the potential contribution of the various renewable energy options (and energy conservation) to the achievement of this objective and the underlying principles. Part 1 of this report was jointly prepared by Ecofys and ECN. Part 2 of this report provides an overview of the current bottlenecks, measures and roles for the Dutch government and the provinces to realize the 2020 renewable energy target [Dutch] Het eerste deel heeft betrekking op de cijfermatige invulling van de 16% doelstelling: de potentiele bijdrage van de verschillende hernieuwbare energie opties (en energiebesparing) aan het halen van deze doelstelling en de uitgangspunten die hieraan ten grondslag liggen. Ecofys en ECN hebben deel I gezamenlijk opgesteld. Deel II van deze rapportage geeft een overzicht van de huidige knelpunten, maatregelen en rollen voor Rijk en Provincie om het 2020 doel voor hernieuwbare energie te bereiken.

The fluorine destruction in stars: First experimental study of the {sup 19}F(p,{alpha}){sup 16}O reaction at astrophysical energies

Energy Technology Data Exchange (ETDEWEB)

La Cognata, M.; Mukhamedzhanov, A.; Spitaleri, C.; Indelicato, I.; Aliotta, M.; Burjan, V.; Cherubini, S.; Coc, A.; Gulino, M.; Hons, Z.; Kiss, G. G.; Kroha, V.; Lamia, L.; Mrazek, J.; Palmerini, S.; Piskor, S.; Pizzone, R. G.; Puglia, S. M. R.; Rapisarda, G. G.; Romano, S. [INFN-LNS, Catania (Italy); Cyclotron Institute, Texas A and M University, College Station, Texas (United States); University of Catania and INFN-LNS, Catania (Italy); and others

2012-11-12

The {sup 19}F(p,{alpha}){sup 16}O reaction is an important fluorine destruction channel in the proton-rich outer layers of asymptotic giant branch (AGB) stars and it might also play a role in hydrogendeficient post-AGB star nucleosynthesis. So far, available direct measurements do not reach the energy region of astrophysical interest (E{sub cm}{approx} 300 keV), because of the hindrance effect of the Coulomb barrier. The Trojan Horse (TH) method was thus used to access this energy region, by extracting the quasi-free contribution to the {sup 2}H({sup 19}F,{alpha}{sup 16}O)n reaction. The TH measurement of the {alpha}{sub 0} channel, which is the dominant one at such energies, shows the presence of resonant structures not observed before that cause an increase of the reaction rate at astrophysical temperatures up to a factor of 1.7, with potential important consequences for stellar nucleosynthesis.

High CpG island methylation ofp16 gene and loss of p16 protein ...

Indian Academy of Sciences (India)

Navya

employed to detect CpG island methylation in p16 promoter region and ... of Fallot;p16 gene;p16 protein;CpG islands;Methylation;Promoter regions ..... Our findings that p16 has a role in heart development is ... Asian Pac J Cancer Prev 15, 75-84. .... phenotype in colorectal cancer using a large population-based sample.

P-barp and pp elastic scattering from 10 GeV to 1000 GeV centre-of-mass energy

International Nuclear Information System (INIS)

Islam, M.M.; Fearnley, T.; Guillaud, J.P.

1984-01-01

Antiproton-proton and proton-proton elastic scattering are studied simultaneously over the energy range √s approx. (10-1000) GeV in a nucleon valence core model proposed earlier. The scattering is described as primarily due to two processes: diffraction and hard scattering. The latter originates from the scattering of a nucleon core off another core. Destructive interference between the two processes produces dips in p-barp and pp differential cross-sections. As energy increases beyond the ISR range (√s = (23-62) GeV), the dips get filled up, and eventually transform into shoulders or breaks at collider energies. Differences between p-barp and pp differential cross-sections persist even at collider energies. Comparison with ISR data shows that the model provides a quantitative description of pp elastic scattering in this energy range. Predictions of p-barp and pp differential cross-sections at future collider energies √s = 800 and 2000 GeV are given. In order to distinguish between competing models, need for measuring the p-barp differential cross-section at the ISR and SPS collider in the abs (t)-range (0.5-2.0) (GeV) 2 is stressed

P-barp and pp elastic scattering from 10 GeV to 1000 GeV centre-of-mass energy

Energy Technology Data Exchange (ETDEWEB)

Islam, M.M. (Connecticut Univ., Storrs (USA). Dept. of Physics); Fearnley, T. (University Coll., London (UK). Dept. of Physics and Astronomy); Guillaud, J.P. (L.A.P.P. - BP909, 74019 Annecy-Le-Vieux Cedex, France)

1984-06-21

Antiproton-proton and proton-proton elastic scattering are studied simultaneously over the energy range ..sqrt..s approx. (10-1000) GeV in a nucleon valence core model proposed earlier. The scattering is described as primarily due to two processes: diffraction and hard scattering. The latter originates from the scattering of a nucleon core off another core. Destructive interference between the two processes produces dips in p-barp and pp differential cross-sections. As energy increases beyond the ISR range (..sqrt..s = (23-62) GeV), the dips get filled up, and eventually transform into shoulders or breaks at collider energies. Differences between p-barp and pp differential cross-sections persist even at collider energies. Comparison with ISR data shows that the model provides a quantitative description of pp elastic scattering in this energy range. Predictions of p-barp and pp differential cross-sections at future collider energies ..sqrt..s = 800 and 2000 GeV are given. In order to distinguish between competing models, need for measuring the p-barp differential cross-section at the ISR and SPS collider in the abs (t)-range (0.5-2.0) (GeV)/sup 2/ is stressed.

76 FR 57956 - Renewable Energy and Energy Efficiency Executive Business Development Mission; Clarification and...

Science.gov (United States)

2011-09-19

... DEPARTMENT OF COMMERCE International Trade Administration Renewable Energy and Energy Efficiency... the Notice of the Renewable Energy and Energy Efficiency Executive Business Development Mission, 76 FR... for Recruitment and Applications section of the Notice of the Renewable Energy and Energy Efficiency...

Asymptotic normalization coefficients for 10B→9Be+p

International Nuclear Information System (INIS)

Mukhamedzhanov, A.M.; Clark, H.L.; Gagliardi, C.A.; Lui, Y.; Trache, L.; Tribble, R.E.; Xu, H.M.; Zhou, X.G.; Burjan, V.; Cejpek, J.; Kroha, V.; Carstoiu, F.

1997-01-01

The differential cross sections for the reactions 9 Be( 10 B, 10 B) 9 Be and 9 Be( 10 B, 9 Be) 10 B have been measured at an incident energy of 100 MeV. The elastic scattering data have been used to determine the optical model parameters for the 9 Be+ 10 B system at this energy. These parameters are then used in distorted-wave Born approximation (DWBA) calculations to predict the cross sections of the 9 Be( 10 B, 9 Be) 10 B proton exchange reaction, populating the ground and low-lying states in 10 B. By normalizing the theoretical DWBA proton exchange cross sections to the experimental ones, the asymptotic normalization coefficients (ANC's), defining the normalization of the tail of the 10 B bound state wave functions in the two-particle channel 9 Be+p, have been found. The ANC for the virtual decay 10 B(g.s.)→ 9 Be+p will be used in an analysis of the 10 B( 7 Be, 8 B) 9 Be reaction to extract the ANC's for 8 B→ 7 Be +p. These ANC's determine the normalization of the 7 Be(p,γ) 8 B radiative capture cross section at very low energies, which is crucially important for nuclear astrophysics. copyright 1997 The American Physical Society

Elastase production by B16-F10 melanoma cells

International Nuclear Information System (INIS)

Shrager, J.B.; Yusa, T.; Netland, P.A.; Zetter, B.R.

1986-01-01

Elastolytic activity was found in sonicates of mouse B16-F10 melanoma cells and in medium conditioned by these cells. Degradation of elastin was determined by measuring the release of soluble 3 H-peptides from labelled insoluble elastin. The activity secreted from B16-F10 cells was soluble and was not associated with membrane vesicles. The secreted activity was partially inhibited by incubation with phenymethylsulfonylfluoride (PMSF) and was abolished by incubation with the alpha-1-protease inhibitor, with pepstatin A or with L-1-tosylamide-2-phenylethyl chloromethyl ketone (TPCK). In contrast, the activity was unaffected by incubation with elastatinal, with the plasmin inhibitor Σ-aminocaproic acid (EACA), the metalloproteinase inhibitor ethylenediamine-tetra-acetic acid (EDTA), the soybean trypsin inhibitor or the trypsin inhibitor N proportional to-p-tosyl-L-lysine chloromethyl ketone (TLCK). These results suggest that the majority of the tumor cell-derived elastolytic activity is attributable to a serine protease that differs in specificity from the well characterized elastases previously isolated from neutrophils, macrophages or from mammalian pancreas. The authors postulate that the release of elastase from lung-colonizing B16-F10 cells may facilitate their invasion of elastin-rich lung tissue

A survey of energy policy priorities in the United States: Energy supply security, economics, and the environment

International Nuclear Information System (INIS)

Manley, Dawn K.; Hines, Valerie A.; Jordan, Matthew W.; Stoltz, Ronald E.

2013-01-01

Security, environment, and economic concerns are commonly identified as three major objectives of energy policy. State and federal governments have set aggressive targets for carbon emissions reductions and for alternative fuel use and increased vehicle efficiency to reduce petroleum consumption. Moreover, jobs creation and GDP growth are often cited as key drivers for energy policies. Previous studies on energy policy decision-making have examined the process for developing and evaluating options using multi-criteria decision analysis tools. In addition, energy opinion polls have either elicited preferences between two goals or whether the public supports a specific policy action. In this article, we report results from a survey of 884 members of professional membership organizations on how the U.S. should prioritize energy policy across the goals of energy supply security, environment and climate, and economics and job creation. The majority favor policymaking that is balanced across all three. Security and economic concerns increase with age for male respondents, whereas environment is the highest priority for females regardless of age. Unlike previous surveys that target the general public and focus on a particular objective or technology, these results provide an example of eliciting a portfolio allocation across multiple energy policy goals from targeted constituents. - Highlights: • We surveyed 884 members of professional membership organizations on how the U.S. should prioritize energy policy. • The paper addresses direct elicitation of energy policy goal portfolio allocation for a large set of energy stakeholders. • The majority of respondents favor policymaking balanced across multiple goals. • We observed differences in priorities based on age and gender. • Respondents expressed a tension in allocating across goals that are interrelated

Alpha decay 225Ac→221Fr

International Nuclear Information System (INIS)

Kudrya, S.A.; Sergienko, V.A.; Gorozhankin, V.M.; Gromov, K.Ya.; Malikov, Sh.R.; Malov, L.A.; Fominykh, V.I.; Tsupko-Sitnikov, V.V.; Chumin, V.G.; Yakushev, E.A.

2002-01-01

In-depth investigation of (α-γ)-coincidences at the 225 Ac decay is carried out. Twenty-one new weak γ-rays are found; 18 γ-rays earlier ascribed to the 225 Ac decay are not confirmed. The quantitative analysis of the (α-γ)-coincidences makes it possible to find the intensity of population of 221 Fr levels by the α decay and multipolarities of five weak γ-transitions. The conversion electron spectrum is investigated in the range of 5-24 keV with a high (some 20 eV) energy resolution. A new M1 type 10.6-keV γ-transition is found. The proposed 225 Ac decay scheme includes 31 excited 221 Fr states. Parities are established for 16 of them. Possible spin values are proposed for 221 Fr levels. Properties of excited 221 Fr states are satisfactorily described by the quasiparticle-phonon nuclear model without the assumption of static octupole deformation

Selection and Evaluation of Priority Domains in Global Energy Internet Standard Development Based on Technology Foresight

Science.gov (United States)

Jin, Yang; Ciwei, Gao; Jing, Zhang; Min, Sun; Jie, Yu

2017-05-01

The selection and evaluation of priority domains in Global Energy Internet standard development will help to break through limits of national investment, thus priority will be given to standardizing technical areas with highest urgency and feasibility. Therefore, in this paper, the process of Delphi survey based on technology foresight is put forward, the evaluation index system of priority domains is established, and the index calculation method is determined. Afterwards, statistical method is used to evaluate the alternative domains. Finally the top four priority domains are determined as follows: Interconnected Network Planning and Simulation Analysis, Interconnected Network Safety Control and Protection, Intelligent Power Transmission and Transformation, and Internet of Things.

75 FR 39244 - Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of Joint Petition for...

Science.gov (United States)

2010-07-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-45-000] Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of Joint Petition for Clarification, or in the Alternative, Request for Limited Waiver June 30, 2010. Take notice that on June 25, 2010, Arizona Public...

Renewable energy: RD&D priorities. Insights from IEA technology programmes

Energy Technology Data Exchange (ETDEWEB)

none

2006-12-19

In order to substantially enhance the share of renewable energy technologies in the energy portfolio, it is imperative to accelerate technological advancement and subsequently reduce costs, in combination with novel applications and deployment. This outcome can be significantly supported by a range of RD and D initiatives, if properly designed and implemented. This publication reviews the current status of the renewable energy technologies portfolio and provides guidance on their mid- and long-term development. The study explores the options for the RD&D to achieve breakthroughs that will lead to large-scale markets and identifies what activities should take priority. It also looks at the benefits of increased RD&D funding in terms of technological advancement and cost improvement. It covers renewable energy technologies in the early research stage through to those that have reached a level of maturity. It also lists national renewable energy RD and D trends in IEA member countries.

45 CFR 2531.20 - Funding priorities.

Science.gov (United States)

2010-10-01

... priorities. The Corporation may choose to set priorities (and to periodically revise such priorities) that... given fiscal year. In setting these priorities, the Corporation will seek to concentrate funds on those... 45 Public Welfare 4 2010-10-01 2010-10-01 false Funding priorities. 2531.20 Section 2531.20 Public...

Proton angular distribution of {sup 16}O(d,p){sup 17}O{sup *} near a deuteron capture resonance; Evolution de la distribution angulaire des protons {sup 16}O(d,p){sup 17}O{sup *} au voisinage d'une resonance de capture du deuteron

Energy Technology Data Exchange (ETDEWEB)

Berthelot, R; Cohen, E; Cotton, H; Farraggi, T; Grjebine, A; Leveque, V; Naggiar, M; Roclawski-Conjeaud, D; Szteinsznaider, D [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

1954-07-01

The study of angular distributions of the protons from the reaction {sup 16}O(d,p){sup 17}O{sup *} (level at 875 keV) was made, using a photographic method, at seven different deuteron energies, from 1.66 to 2.20 MeV (obtained with the Saclay electrostatic generator). The analysis of results shows that the angular distribution for forward angles is for each chosen energy in good agreement with the stripping theory (l = 0), even at the maximum of the capture resonance of the deuteron, about 2.1 MeV. Moreover, the differential cross section at 7 deg reaches a maximum for this resonance energy. (author) [French] L'etude des distributions angulaires des protons emis au cours de la reaction {sup 16}O(d,p){sup 17}O{sup *} (niveau a 875 key) a ete effectuee, par une methode photographique, pour 7 energies differentes de deuterons comprises entre 1,66 et 2,20 MeV (obtenues grace a l'accelerateur electrostatique de Saclay). L'analyse des resultats montre que la distribution angulaire vers l'avant est, pour toutes ces energies, en bon accord avec la theorie du ''stripping'' ( 1=0), meme au maximum de la resonance de capture du deuteron situee vers 2,1 MeV. De plus, la section efficace differentielle a 7 deg passe par un maximum pour cette energie de resonance. (auteur)

10 CFR 904.10 - Excess energy.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Excess energy. 904.10 Section 904.10 Energy DEPARTMENT OF ENERGY GENERAL REGULATIONS FOR THE CHARGES FOR THE SALE OF POWER FROM THE BOULDER CANYON PROJECT Power Marketing § 904.10 Excess energy. (a) If excess Energy is determined by the United States to be available...

75 FR 3217 - Eagle Crest Energy Company; Notice of Application Ready for Environmental Analysis and Soliciting...

Science.gov (United States)

2010-01-20

... reverse osmosis system; (15) a desalination area; (16) a buried water supply pipeline ranging from 12- to... notice: (1) A copy of the water quality certification; (2) a copy of the request for certification... of water quality certification. Kimberly D. Bose, Secretary. [FR Doc. 2010-913 Filed 1-19-10; 8:45 am...

The 4p6 autoionization cross section of Rb atoms excited by low-energy electron impact

International Nuclear Information System (INIS)

Borovik, A; Roman, V; Kupliauskienė, A

2012-01-01

The autoionization cross section of rubidium atoms was obtained by measuring the total normalized intensities of ejected-electron spectra arising from the decay of the 4p 5 n 1 l 1 n 2 l 2 autoionizing levels. The electron impact energy range from the 4p 6 excitation threshold at 15.31 up to 50 eV was investigated. The cross section reaches the maximum value of (2.9 ± 0.6) × 10 −16  cm 2 at 21.8 eV impact energy. The general behaviours of the cross section and the role of particular autoionizing configurations in its formation were considered on the basis of large-scale configuration interaction calculations of energies, cross sections, autoionization probabilities in 5snl(n ⩽ 7; l ⩽ 4) and 4d nl(n ⩽ 5; l ⩽ 2) configurations as well as the measured excitation functions for the lowest levels in 5s 2 and 4d5s configurations. The resonance behaviour of the cross section between 15.3 and 18.5 eV impact energy is caused exclusively by the negative-ion resonances present close to the excitation thresholds of the (5s 2 ) 2 P and (4d5s) 4 P autoionizing levels. At higher impact energies, the autoionization cross section is composed of contributions from the high-lying quartet and doublet levels in 4d5s, 5p and 5s5p, 5d, 6s, 6p configurations. From the comparison of the present data with available experimental and calculated ionization cross sections, the 5s + 4p 6 direct ionization cross section of rubidium atoms was determined with the maximum value of (7.2 ± 2.2) × 10 −16  cm 2 at 36 eV. It was also found that the 4p 6 excitation–autoionization is the dominant indirect ionization process contributing over 30% of the total single ionization of rubidium atoms by electron impact in the 15.3–50 eV energy range. (paper)

Complete Cubic and Quartic Couplings of 16 and $\\bar{16}$ in SO(10) Unification

CERN Document Server

Syed, R M; Nath, Pran; Syed, Raza M.

2001-01-01

A recently derived basic theorem on the decomposition of SO(2N) vertices is used to obtain a complete analytic determination of all SO(10) invariant cubic superpotential couplings involving $16_{\\pm}$ semispinors of SO(10) chirality $\\pm$ and tensor representations. In addition to the superpotential couplings computed previously using the basic theorem involving the 10, 120 and $\\bar{126}$ tensor representations we compute here couplings involving the 1, 45 and 210 dimensional tensor representations, i.e., we compute the $\\bar{16}_{\\mp}16_{\\pm}1$,$\\bar{16}_{\\mp}16_{\\pm}45$ and $\\bar{16}_{\\mp}16_{\\pm}210$ Higgs couplings in the superpotential. A complete determination of dimension five operators in the superpotential arising from the mediation of the 1, 45 and 210 dimensional representations is also given. The vector couplings $\\bar{16}_{\\pm}16_{\\pm}1$, $\\bar{16}_{\\pm}16_{\\pm}45$ and $\\bar{16}_{\\pm}16_{\\pm}210$ are also analyzed. The role of large tensor representations and the possible application of results ...

Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways

Directory of Open Access Journals (Sweden)

Su Jin Kang

2015-10-01

Full Text Available Plants rich in antioxidant substances may be useful for preventing skin aging. Pomegranates, containing flavonoids and other polyphenolic compounds, are widely consumed due to their beneficial properties. We examined the underlying mechanisms of dried pomegranate concentrate powder (PCP on melanin synthesis in B16F10 melanoma cells. The antioxidant effects of PCP were determined by measuring free radical scavenging capacity and transcript levels of antioxidant enzymes. To explore the inhibitory effects of PCP on melanin synthesis, we measured tyrosinase activity and melanin content in α-melanocyte stimulating hormone (α-MSH-stimulated B16F10 cells. In addition, the levels of tyrosinase-related protein-1 (TRP-1, TRP-2, tyrosinase, and microphthalmia-associated transcription factor (MITF expression were determined by Western blotting. Changes in the phosphorylation status of protein kinase A (PKA, cAMP response element-binding protein (CREB, mitogen-activated protein kinases (MAPKs, phosphatidylinositol 3-kinase (PI3K, serine/threonine kinase Akt, and glycogen kinase 3β (GSK3β were also examined. The free radical scavenging activity of PCP increased in a dose-dependent manner. In PCP-treated B16F10 cells, transcript levels of glutathione peroxidase-1 (GPx-1 were increased compared with α-MSH-stimulated cells. In addition, PCP led to the down-regulation of phospho-p38, phospho-PKA, phospho-CREB, phospho-GSK3β, MITF, and TRP-1 compared with α-MSH-stimulated B16F10 cells. We believe this effect may be associated with PCP activity, which leads to the inhibition of melanin production and tyrosinase activity. These results suggest that PCP decreases tyrosinase activity and melanin production via inactivation of the p38 and PKA signaling pathways, and subsequently decreases phosphorylation of CREB, MITF, and melanogenic enzymes. These observations provided new insights on the molecular mechanisms of the skin-whitening property of PCP.

Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways

Science.gov (United States)

Kang, Su Jin; Choi, Beom Rak; Lee, Eun Kyoung; Kim, Seung Hee; Yi, Hae Yeon; Park, Hye Rim; Song, Chang Hyun; Lee, Young Joon; Ku, Sae Kwang

2015-01-01

Plants rich in antioxidant substances may be useful for preventing skin aging. Pomegranates, containing flavonoids and other polyphenolic compounds, are widely consumed due to their beneficial properties. We examined the underlying mechanisms of dried pomegranate concentrate powder (PCP) on melanin synthesis in B16F10 melanoma cells. The antioxidant effects of PCP were determined by measuring free radical scavenging capacity and transcript levels of antioxidant enzymes. To explore the inhibitory effects of PCP on melanin synthesis, we measured tyrosinase activity and melanin content in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cells. In addition, the levels of tyrosinase-related protein-1 (TRP-1), TRP-2, tyrosinase, and microphthalmia-associated transcription factor (MITF) expression were determined by Western blotting. Changes in the phosphorylation status of protein kinase A (PKA), cAMP response element-binding protein (CREB), mitogen-activated protein kinases (MAPKs), phosphatidylinositol 3-kinase (PI3K), serine/threonine kinase Akt, and glycogen kinase 3β (GSK3β) were also examined. The free radical scavenging activity of PCP increased in a dose-dependent manner. In PCP-treated B16F10 cells, transcript levels of glutathione peroxidase-1 (GPx-1) were increased compared with α-MSH-stimulated cells. In addition, PCP led to the down-regulation of phospho-p38, phospho-PKA, phospho-CREB, phospho-GSK3β, MITF, and TRP-1 compared with α-MSH-stimulated B16F10 cells. We believe this effect may be associated with PCP activity, which leads to the inhibition of melanin production and tyrosinase activity. These results suggest that PCP decreases tyrosinase activity and melanin production via inactivation of the p38 and PKA signaling pathways, and subsequently decreases phosphorylation of CREB, MITF, and melanogenic enzymes. These observations provided new insights on the molecular mechanisms of the skin-whitening property of PCP. PMID:26473849

50 CFR Figure 4 to Part 223 - Georgia TED

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Georgia TED 4 Figure 4 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig. 4 Figure 4 to Part 223—Georgia TED EC01JY91.048 [52 FR...

Single pion and several pions production in π+p interactions at 1.6 GeV/c

International Nuclear Information System (INIS)

Jabiol, M.A.

1966-01-01

The production of ρ + , N 33 * , and η 0 was observed in π + p interactions at 1.6 GeV/c. In the reactions where one pion is created, the comparison between the experimental distribution of the ρ + and the N 33 * with the predictions of the peripheral model modified by absorption effects permits the conclusion that the contribution of this model is important, but that other effects such as interferences between ρ + and N 33 * are not negligible. In the reactions where several pions are created, the branching ratios of some decay modes of η0 are evaluated and the associated production of η 0 and N 33 * is observed. (author) [fr

Human Health Risk Assessment of 16 Priority Polycyclic Aromatic Hydrocarbons in Soils of Chattanooga, Tennessee, USA.

Science.gov (United States)

Hussar, Erika; Richards, Sean; Lin, Zhi-Qing; Dixon, Robert P; Johnson, Kevin A

2012-11-01

South Chattanooga has been home to foundries, coke furnaces, chemical, wood preserving, tanning and textile plants for over 100 years. Most of the industries were in place before any significant development of residential property in the area. During the 1950s and 1960s, however, the government purchased inexpensive property and constructed public housing projects in South Chattanooga. Many neighborhoods that surround the Chattanooga Creek were previous dumping grounds for industry. Polycyclic aromatic hydrocarbons (PAHs) comprised the largest component of the dumping and airborne industrial emissions. To address the human exposure to these PAHs, a broad study of South Chattanooga soil contaminant concentrations was conducted on 20 sites across the city. Sixteen priority pollutant PAHs were quantified at two depths (0-10cm and 10-20cm) and compared against reference site soils, as well as to soils from industrially-impacted areas in Germany, China, and the US. From these data, the probability that people would encounter levels exceeding EPA Residential Preliminary Remediation Goals (PRG) was calculated. Results indicate that South Chattanooga soils have relatively high concentrations of total PAHs, specifically Benzo[a]pyrene (B[a]P). These high concentrations of B[a]P were somewhat ubiquitous in South Chattanooga. Indeed, there is a high probability (88%) of encountering soil in South Chattanooga that exceeds the EPA PRG for B[a]P. However, there is a low probability (15%) of encountering a site with ∑PAHs exceeding EPA PRG guidelines.

Formation of the priority directions of innovative strategic energy management

Science.gov (United States)

Mottaeva, Asiiat; Minnullina, Anna

2017-10-01

Article is devoted to the matter of the ensuring long-term potential of dynamic growth of the Russian economy, its sustainable development in which the special role is assigned to the energy industry. Inclusion of the stage of management of the human capital, which becomes one of priority levers in the field of management of the industrial enterprises, into the in structure of strategy of planning subsequently represents one of innovative steps at the heart of power management. In work the algorithm of the development of the key performance indicators of the human capital on the basis of stage-by-stage problem definition of energy saving, search of the centers of responsibility in energy consumption and quality control of the involved productions is offered in the article. The application of the offered innovative algorithm might promote the formation of high culture of energy saving and the decrease in the level of resistance to organizational changes.

Complete cubic and quartic couplings of 16 and 16-bar in SO(10) unification

International Nuclear Information System (INIS)

Nath, Pran; Syed, Raza M.

2001-01-01

A recently derived basic theorem on the decomposition of SO(2N) vertices is used to obtain a complete analytic determination of all SO(10)-invariant cubic superpotential couplings involving 16 ± semispinors of SO(10) chirality ± and tensor representations. In addition to the superpotential couplings computed previously using the basic theorem involving the 10, 120 and 126-bar tensor representations we compute here couplings involving the 1-, 45- and 210-dimensional tensor representations, i.e., we compute the 16-bar -+ 16 ± 1, 16-bar -+ 16 ± 45 and 16-bar -+ 16 ± 210 Higgs couplings in the superpotential. A complete determination of dimension five operators in the superpotential arising from the mediation of the 1-, 45- and 210-dimensional representations is also given. The vector couplings 16-bar ± 16 ± 1, 16-bar ± 16 ± 45 and 16-bar ± 16 ± 210 are also analyzed. The role of large tensor representations and the possible application of results derived here in model building are discussed

Fertilizer consumption and energy input for 16 crops in the United States

Science.gov (United States)

Amenumey, Sheila E.; Capel, Paul D.

2014-01-01

Fertilizer use by U.S. agriculture has increased over the past few decades. The production and transportation of fertilizers (nitrogen, N; phosphorus, P; potassium, K) are energy intensive. In general, about a third of the total energy input to crop production goes to the production of fertilizers, one-third to mechanization, and one-third to other inputs including labor, transportation, pesticides, and electricity. For some crops, fertilizer is the largest proportion of total energy inputs. Energy required for the production and transportation of fertilizers, as a percentage of total energy input, was determined for 16 crops in the U.S. to be: 19–60% for seven grains, 10–41% for two oilseeds, 25% for potatoes, 12–30% for three vegetables, 2–23% for two fruits, and 3% for dry beans. The harvested-area weighted-average of the fraction of crop fertilizer energy to the total input energy was 28%. The current sources of fertilizers for U.S. agriculture are dependent on imports, availability of natural gas, or limited mineral resources. Given these dependencies plus the high energy costs for fertilizers, an integrated approach for their efficient and sustainable use is needed that will simultaneously maintain or increase crop yields and food quality while decreasing adverse impacts on the environment.

28 CFR 16.10 - Preservation of records.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Preservation of records. 16.10 Section 16.10 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION... title 44 of the United States Code or the National Archives and Records Administration's General Records...

76 FR 57982 - Building Energy Codes Cost Analysis

Science.gov (United States)

2011-09-19

... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy [Docket No. EERE-2011-BT-BC-0046] Building Energy Codes Cost Analysis Correction In notice document 2011-23236 beginning on page...-23236 Filed 9-16-11; 8:45 am] BILLING CODE 1505-01-P ...

Priority mitigation measures in non-energy sector in Kazakstan

Energy Technology Data Exchange (ETDEWEB)

Mizina, S.V.; Pilifosova, O.V.; Gossen, E.F.

1996-12-31

Fulfilling the Commitments on UN FCCC through the U.S. Country Studies Program, Kazakstan has developed the national GHG Inventory, vulnerability and adaptation assessment and estimated the possibility of mitigation measures in certain sectors. Next step is developing National Climate Change Action Plan. That process includes such major steps as setting priorities in mitigation measures and technologies, their comprehensive evaluation, preparation implementation strategies, developing the procedure of incorporation of the National Action Plan into other development plans and programs. This paper presents programs and measures that can reduce GHG emissions in non-energy sector. Measures in land-use change and forestry, agriculture and coal mining are considered. Current situation in non-energy sector of Kazakstan is discussed. The amount of GHG emissions reduction and cost analysis presented in this paper was developed with the use of IPCC recommendations.

Deus: metafísica e pensar pós-metafísico (God: metaphysics and post-metaphysical thinking - DOI: 10.5752/P.2175-5841.2010v8n16p8

Directory of Open Access Journals (Sweden)

Ibraim Vitor de Oliveira

2010-04-01

Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Editorial - Dossiê: Pensamento pós-metafísico e discurso sobre Deus – (Dossier: Post-metaphysical thought and speech about God Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Deus: metafísica e pensar pós-metafísico (God: metaphysics and post-metaphysical thinking - DOI: 10.5752/P.2175-5841.2010v8n16p8 

Mapping and Measuring European Local Governments’ Priorities for a Sustainable and Low-Carbon Energy Future

Directory of Open Access Journals (Sweden)

Stelios Grafakos

2015-10-01

Full Text Available The main objective of this article is to assess the priorities of local governments (LGs in Europe regarding climate change mitigation technologies evaluation in the electricity sector and to provide important insights for energy policy design. The study applies a hybrid weighting methodology to elicit LGs’ preferences in a constructive and iterative way regarding the evaluation criteria of low-carbon energy technologies. Furthermore, the study employs three data collection and preference elicitation methods, namely: survey, workshop, and webinar. The study was conducted across thirty one (31 European LGs that were categorized according to three variables: population size, geographical region and gross domestic product (GDP per capita. The analysis shows that “CO2 emissions” is the most important criterion among European LGs, followed by “mortality and morbidity” and “ecosystem damages”. The results illustrate the potential synergies of climate and energy policies for addressing both CO2 emissions and air pollution. It was also found, based on a correlation analysis, that LGs with higher GDP per capita tend to provide higher weights to criteria related to security of energy supply and technological innovation. The current study provides insights on the actual LGs’ priorities that are important to consider during low-carbon energy technologies evaluation and energy policy design. Interestingly, the results of the European LGs’ preferences clearly show that the EU climate policy objectives have reached different levels of governance—and at this particular case, the local level. Furthermore, the developed methodology could be applied at different geographical regions to map other regions’ LG priorities, but also at a group decision making context to elicit relevant stakeholders’ preferences regarding low-carbon energy technologies and policy objectives.

Electrical performance of the InGaP solar cell irradiated with low energy electron beams

Energy Technology Data Exchange (ETDEWEB)

Okuno, Yasuki; Okuda, Shuichi; Kojima, Takeo; Oka, Takashi [Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai City, Osaka (Japan); Kawakita, Shirou; Imaizumi, Mitsuru; Kusawake, Hiroaki [Japan Aerospace Exploration Agency (JAXA), 2-1-1 Sengen, Tsukuba, Ibaraki (Japan)

2015-06-15

The investigation of the radiation degradation characteristics of InGaP space solar cells is important. In order to understand the mechanism of the degradation by radiation the samples of the InGaP solar cell were irradiated in vacuum and at ambient temperature with electron beams from a Cockcroft-Walton type accelerator at Osaka Prefecture University. The threshold energies for recoil were obtained by theoretical calculation. The energies and the fluences of the electron beams were from 60 to 400 keV and from 3 x 10{sup 14} to 3 x 10{sup 16} cm{sup -2}, respectively. The light-current-voltage measurements were performed. The degradation of Isc caused by the defects related to the phosphorus atoms was observed and the degradation was suppressed by irradiation at an energy higher than the threshold energy for recoiling Indium atoms. At an energy of 60 keV, where the recoil does not occur, the V{sub oc} was degraded. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

A plausible picture of high-energy proton-nucleus collisions

International Nuclear Information System (INIS)

Kim, C.O.

1976-01-01

Results experimentally obtained from jets of E(p)=10-10 3 GeV in nuclear emulsion show that the target nucleus in proton-nucleus collisions seems to present ''limiting fragmentation''. In the same energy range, proton-nucleus collisions resemble closely proton-proton collisions and asymmetric shape of rapidities is only caused by the break-up products of heavy targets [fr

Wolf-Hirschhorn (4p-) syndrome: prenatal diagnosis, molecular cytogenetic characterization and association with a 1.2-Mb microduplication at 8p22-p21.3 and a 1.1-Mb microduplication at 10p15.3 in a fetus with an apparently pure 4p deletion.

Science.gov (United States)

Chen, Chih-Ping; Su, Yi-Ning; Chen, Yi-Yung; Su, Jun-Wei; Chern, Schu-Rern; Chen, Yu-Ting; Chen, Wen-Lin; Chen, Li-Feng; Wang, Wayseen

2011-12-01

To present prenatal diagnosis and molecular cytogenetic characterization of Wolf-Hirschhorn syndrome (WHS) associated with microduplications at 8p and 10p in a fetus with an apparently pure 4p deletion. A 35-year-old gravida 2, para 1 woman underwent amniocentesis at 18 weeks of gestation because of advanced maternal age. Her husband was 38 years of age. There was no family history of congenital malformations. Amniocentesis revealed a karyotype of 46,XY,del(4p16.1). The parental karyotypes were normal. Array comparative genomic hybridization (aCGH) analysis revealed a 6.5-Mb deletion at 4p16.3-p16.1, a 1.2-Mb microduplication at 8p22-p21.3, and a 1.1-Mb microduplication at 10p15.3, or arr cgh 4p16.3p16.1 (0-6,531,998 bp)×1, 8p22p21.3 (18,705,388-19,940,445 bp)×3, 10p15.3 (0-1,105,065 bp)×3. Polymorphic DNA marker analysis confirmed a paternal origin of 4p deletion. Prenatal ultrasound revealed facial dysmorphism and hypospadias. The aCGH analysis of the parents revealed no genomic imbalance. Fluorescence in situ hybridization study showed an unbalanced reciprocal translocation between chromosomes 4 and 10 at bands 4p16.1 and 10p15.3. The cytogenetic result, thus, was 46,XY,der(4)t(4;10)(p16.1;p15.3),dup(8)(p21.3p22). The parents elected to terminate the pregnancy, and a 470-g malformed fetus was delivered. The present case provides evidence that an apparently pure 4p deletion can be associated with subtle chromosome imbalances in other chromosomes. Copyright © 2011. Published by Elsevier B.V.

Expression of p16(INK4A) gene in human pituitary tumours.

Science.gov (United States)

Machiavelli, Gloria; Cotignola, Javier; Danilowicz, Karina; Carbonara, Carolina; Paes de Lima, Andrea; Basso, Armando; Bruno, Oscar Domingo; Szijan, Irene

2008-01-01

Pituitary adenomas comprise 10-15% of primary intracranial tumours but the mechanisms leading to tumour development are yet to be clearly established. The retinoblastoma pathway, which regulates the progression through the cell cycle, is often deregulated in different types of tumours. We studied the cyclin-dependent kinase inhibitor p16(INK4A) gene expression at mRNA level in human pituitary adenomas. Forty-six tumour specimens of different subtypes, 21 clinically non-functioning, 12 growth hormone-secreting, 6 prolactin-secreting, 6 adrenocorticotropin-secreting, and 1 thyrotropin-secreting tumours were studied. All clinically non-functioning and most of the hormone-secreting tumours were macroadenomas (38/46). The RT-PCR assay and electrophoresis of the PCR-products showed that p16(INK4A) mRNA was undetectable in: 62% of non-functioning, 8% of growth hormone-secreting, 17% of prolactin-secreting and 17% of adrenocorticotropin-secreting adenomas. Forty percent of all macroadenomas and 25% of microadenomas had negative p16(INK4A) mRNA, the latter results suggest that the absence of p16(INK4A) product might be an early event in tumours with no expression of this suppressor gene. Within the non-functioning adenomas 63% were "null cell" and 37% were positive for some hormone, both subgroups showed similar percentage of cases with absence of p16(INK4A) mRNA. Our results show that clinically non-functioning macroadenomas have impaired p16(INK4A) expression in a clearly higher proportion than any other pituitary tumour subtype investigated. Other regulatory pathways may be implicated in the development of tumours with positive p16(INK4A) expression.

Selection and evaluation of phosphate-solubilizing bacteria from grapevine rhizospheres for use as biofertilizers

International Nuclear Information System (INIS)

Liu, M.; Liu, X.; Cheng, B.S.; Ma, X.L.; Lyu, X.; Zhao, X.; Ju, Y.; Min, Z.; Fang, Y.

2016-01-01

Phosphate-solubilizing bacteria (PSB) have the ability to solubilize insoluble phosphorus (P) and release soluble P. Extensive research has been performed with respect to PSB isolation from the rhizospheres of various plants, but little is known about the prevalence of PSB in the grapevine rhizosphere. In this study, we aimed to isolate and identify PSB from the grapevine rhizosphere in five vineyards of Northwest China, to characterize their plant-growth-promoting (PGP) traits, evaluate the effect of stress on their phosphate-solubilizing activity (PSA), and test their ability to stimulate the growth of Vitis vinifera L. cv. Cabernet Sauvignon. From the vineyard soils, 66 PSB isolates were screened, and 10 strains with high PSA were identified by 16S rRNA sequencing. Sequence analysis revealed that these 10 strains belonged to 4 genera and 5 species: Bacillus aryabhattai, B. megaterium, Klebsiella variicola, Stenotrophomonas rhizophila, and Enterobacter aerogenes. The selected PSB strains JY17 (B. aryabhattai) and JY22 (B. aryabhattai) were positive for multiple PGP traits, including nitrogen fixation and production of indole acetic acid (IAA), siderophores, 1-aminocyclopropane-1-carboxylate (ACC) deaminase, chitinase, and protease. JY17 and JY22 showed strong PSA under stress conditions of high pH, high salt, and high temperature. Therefore, these two isolates can be used as biofertilizers in saline-alkaline soils. The inoculation with PSB significantly facilitated the growth of V. vinifera cv. Cabernet Sauvignon under greenhouse conditions. Use of these PSB as biofertilizers will increase the available P content in soils, minimize P-fertilizer application, reduce environmental pollution, and promote sustainable agriculture.

Selection and evaluation of phosphate-solubilizing bacteria from grapevine rhizospheres for use as biofertilizers

Energy Technology Data Exchange (ETDEWEB)

Liu, M.; Liu, X.; Cheng, B.S.; Ma, X.L.; Lyu, X.; Zhao, X.; Ju, Y.; Min, Z.; Fang, Y.

2016-07-01

Phosphate-solubilizing bacteria (PSB) have the ability to solubilize insoluble phosphorus (P) and release soluble P. Extensive research has been performed with respect to PSB isolation from the rhizospheres of various plants, but little is known about the prevalence of PSB in the grapevine rhizosphere. In this study, we aimed to isolate and identify PSB from the grapevine rhizosphere in five vineyards of Northwest China, to characterize their plant-growth-promoting (PGP) traits, evaluate the effect of stress on their phosphate-solubilizing activity (PSA), and test their ability to stimulate the growth of Vitis vinifera L. cv. Cabernet Sauvignon. From the vineyard soils, 66 PSB isolates were screened, and 10 strains with high PSA were identified by 16S rRNA sequencing. Sequence analysis revealed that these 10 strains belonged to 4 genera and 5 species: Bacillus aryabhattai, B. megaterium, Klebsiella variicola, Stenotrophomonas rhizophila, and Enterobacter aerogenes. The selected PSB strains JY17 (B. aryabhattai) and JY22 (B. aryabhattai) were positive for multiple PGP traits, including nitrogen fixation and production of indole acetic acid (IAA), siderophores, 1-aminocyclopropane-1-carboxylate (ACC) deaminase, chitinase, and protease. JY17 and JY22 showed strong PSA under stress conditions of high pH, high salt, and high temperature. Therefore, these two isolates can be used as biofertilizers in saline-alkaline soils. The inoculation with PSB significantly facilitated the growth of V. vinifera cv. Cabernet Sauvignon under greenhouse conditions. Use of these PSB as biofertilizers will increase the available P content in soils, minimize P-fertilizer application, reduce environmental pollution, and promote sustainable agriculture.

Participant priorities for future market development : IMO public consultation report : issue 1.0

International Nuclear Information System (INIS)

2002-01-01

As part of the Independent Electricity Market Operator's (IMO) consultation process on market development priorities, a workshop was held in January 2002 to put forward several market design issues. The 112 delegates included market participants and other stakeholders representing consumers, environmental interest groups and the financial community. The nine main market design issues that need to be addressed over the next several years are: (1) the energy forward market, (2) the capacity reserve market, (3) location marginal pricing, (4) a capability for full assignment of physical bilateral contracts, (5) the export of operating reserve, (6) moving to real time bidding, (7) encouraging dispatchability and demand side responsiveness, (8) transmission expansion, and (9) introducing markets in ancillary services. Sections of the market rules have been deferred to after market opening, and several market development obligations have been placed on the IMO, such as recommendations on the need for location pricing and its implementation timetable. It is expected that significant resources, such as staff, will be required to ensure a smooth opening of the electricity market. It is also noted that US initiatives will affect the IMO's business environment. Prior to the workshop, the participants were asked to rank the nine potential priority issues. The rankings are included in the appendix. Results indicate that location marginal pricing ranks as the first priority, followed by energy forwards market, and then the capacity reserves market. Transmission expansion ranked sixth overall. Harmonisation with the US Northeast was also mentioned in reference to the implementation of day ahead market, location marginal pricing and the implementation of capacity reserve markets. The next step in this IMO consultation process is the development of a work-plan for managing the issues over the medium term. 2 tabs., 1 fig., 4 appendices

Influence of Mechanical Loading on the Integrity and Performance of Energy Harvesting and Storage Materials at the Micron and Submicron Scales

Science.gov (United States)

2016-04-01

16] J. Saunier, F. Alloin, J.Y. Sanchez, L. Maniguet, “Plasticized microporous poly(vinylidene fluoride) separators for lithium-ion batteries. III... International 5, pp. 133-1341, (2013). [20] X.H. Liu, Y. Liu, A. Kushima, S. Zhang, T. Zhu, J. Li, J.Y. Huang, “In Situ TEM Experiment of Electrochemical

Study of high-energy nucleus-nucleus interactions with the enlarged NA10 dimuon spectrometer

CERN Multimedia

Dimuon production is studied in $^{16}$0 - $^{238}$U and $^{32}$S - $^{238}$U collisions at the maximum possible luminosity of $\\sim10^{7}$ interactions per pulse using the NA10 spectrometer to which beam counters, an active segmented target and an electromagnetic calorimeter have been added. Thermal dimuons are expected to be emitted from a quark-gluon plasma at a detectable rate in the 1-3 GeV/c$^{2}$ transverse mass range, and to differ from ordinary dimuons by their $P_{T}$ and rapidity distribution. Particular emphasis is put on the $J/\\psi$ meson whose $\\mu\\mu$ decays are studied in detail. It is expected to be suppressed when a quark-gluon plasma is formed (Debye screening of the colour field). The correlations of the dimuon variables with charged multiplicity and neutral energy flow distributions are studied event by event. The energy density is estimated from the measured transverse neutral energy. Also $p$ - $^{228}$U collisions are studied in the same apparatus with the purpose of establishing a da...

Expressão de p53, p16 E COX-2 em carcinoma escamoso de esôfago e associação histopatológica p53, p16 E COX-2 expression in esophageal squamous cell carcinoma and histopathological association

Directory of Open Access Journals (Sweden)

Izabella Paz Danezi Felin

2008-12-01

Full Text Available RACIONAL: O câncer de esôfago representa cerca de 2% dos tumores malignos e a terceira causa mais comum de câncer do trato gastrointestinal. A associação do prognóstico do câncer de esôfago com alguns marcadores imunoistoquímicos, como as proteínas p53, p16 e a ciclooxigenase 2 (COX-2 tem sido relatada. A detecção de marcadores moleculares através de imunoistoquímica pode ser utilizada para avaliação prognóstica. OBJETIVOS: Investigar a associação entre a expressão das proteínas p53, p16 e a COX-2 com o estádio do carcinoma escamoso de esôfago. MÉTODOS: Foram analisadas 31 amostras de ressecção cirúrgica por esofagectomia diagnosticadas como carcinoma de células escamosas de esôfago e 31 amostras não-tumorais referentes a cada caso. Realizou-se a revisão histopatológica e o estádio pTNM. Amostras tumorais e não-tumorais adjacentes foram submetidas a análise imunoistoquímica para avaliar o conteúdo das proteínas p53, p16 e COX-2. Foi considerada positiva a expressão nuclear para p53 em quantidade igual ou superior a 10,00% das células e presença da expressão citoplasmática de acordo com três escores (1, 2, 3 de intensidade (leve, moderada, acentuada de imunocoloração para COX-2. RESULTADOS: Em área tumoral, as análises revelaram 48,38% de positividade para p53, 16,12% de positividade para p16, e 100,00% de positividade escores 1+, 2+ ou 3+ para COX-2. No entanto, quando se avaliou possível relação da expressão destes marcadores com o estádio, apenas a COX-2, escore 3+ intensidade acentuada mostraram associação significativa. CONCLUSÃO: O presente estudo demonstrou que existe relação positiva entre a expressão de COX-2, escore 3+ e estádio mais avançado no carcinoma de esôfago.BACKGROUND: The esophageal carcinoma represents about 2% of malignant tumors and is the third most common cause of gastrointestinal cancer. The correlation between immunohistochemistry markers, such as p53, p16

Salivary flow rate and pH in patients with oral pathologies.

Science.gov (United States)

Foglio-Bonda, P L; Brilli, K; Pattarino, F; Foglio-Bonda, A

2017-01-01

Determine salivary pH and flow rate (FR) in a sample of 164 patients who came to Oral Pathology ambulatory, 84 suffering from oral lesions and 80 without oral lesions. Another aim was to evaluate factors that influence salivary flow rate. Subjects underwent clinical examination and completed an anamnestic questionnaire in order to obtain useful information that was used to classify participants in different groups. Unstimulated whole saliva (UWS) was collected using the spitting method at 11:00 am. The FR was evaluated with the weighing technique and a portable pHmeter, equipped with a microelectrode, was used to measure pH. Both univariate and classification (single and Random Forest) analyses were performed. The data analysis showed that FR and pH showed significant differences (p pH = 6.69) and the ones without oral lesions (FR = 0.492 mL/min, pH = 6.96). By Random Forest, oral lesions and antihypertensive drugs were ranked in the top two among the evaluated variables to discretize subjects with FR = 0.16 mL/min. Our study shows that there is a relationship between oral lesions, antihypertensive drugs and alteration of pH and FR.

Study and use of an infrared camera optimized for ground based observations in the 10 micron wavelength range

International Nuclear Information System (INIS)

Remy, Sophie

1991-01-01

Astronomical observations in the 10 micron atmospheric window provide very important information for many of astrophysical topics. But because of the very large terrestrial photon background at that wavelength, ground based observations have been impeded. On the other band, the ground based telescopes offer a greater angular resolution than the spatially based telescopes. The recent development of detector arrays for the mid infrared range made easier the development of infrared cameras with optimized detectors for astronomical observations from the ground. The CAMIRAS infrared camera, built by the 'Service d'Astrophysique' in Saclay is the instrument we have studied and we present its performances. Its sensitivity, given for an integration time of one minute on source and a signal to noise ratio of 3, is 0.15 Jy for punctual sources, and 20 mJy arcs"-"2 for extended sources. But we need to get rid of the enormous photon background so we have to find a better way of observation based on modulation techniques as 'chopping' or 'nodding'. Thus we show that a modulation about 1 Hz is satisfactory with our detectors arrays without perturbing the signal to noise ratio. As we have a good instrument and because we are able to get rid of the photon background, we can study astronomical objects. Results from a comet, dusty stellar disks, and an ultra-luminous galaxy are presented. (author) [fr

The priorities of the energy infrastructure modernization in rural areas of the Komi Republic

Directory of Open Access Journals (Sweden)

Larisa Viktorovna Chaika

2015-05-01

Full Text Available The article presents the problems of development and modernization of energy infrastructure priorities in rural areas of the Komi Republic. For the most part of rural population the achieved level of energy supply is the necessary minimum for the needs, and it has the low parameters of the energy and economy efficiency. The main directions of the rural energy supply modernization should be: the gas supply system development, the electric grid capacity growth and the construction of the modern small energy technologies (small central heating and power plants, modular boiler plants, efficient solid fuel boilers

15 CFR 700.16 - Changes or cancellations of priority ratings and rated orders.

Science.gov (United States)

2010-01-01

... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE NATIONAL SECURITY INDUSTRIAL BASE REGULATIONS DEFENSE PRIORITIES AND ALLOCATIONS SYSTEM Industrial Priorities § 700...

The deexcitation of the Ar (3P2, 3p1 and 1P1) states as measured by absorption both in pure argon and in the presence of additives

International Nuclear Information System (INIS)

Dutuit, Odile

1974-01-01

The de-excitation of the 3 P 2 , 3 p 1 and 1 P 1 states of argon was studied in pure argon between 10 and 200 torr and in Ar + CO and Ar + H 2 mixtures. These states are populated after excitation of the gas by a short (20 ns) pulse of 500 keV electrons (FEBETRON). Under our experimental conditions, the relation between the measured optical density of the lines studied and the concentration of absorbing species was found to be: DO = log I 0 /I ∝ (lC) n with n = 0,4. The three body rate constants k 2 were measured for the two resonant states 3 p 1 (k 2 = (1,65 ± 0,3) x 10 -32 cm 6 s -1 ) and 1 P 1 (k 2 = (1,0 ± 0,2) x 10 -32 cm 6 s -1 ); they had not been considered in previous low pressure studies. For the metastable state 3 P 2 , the measured value of k 2 ((1,6 ± 0,3) x 10 -32 cm 6 s -1 ) is in good agreement with those found in the literature. However, our two body rate constant k 1 is about ten times higher than that found in measurements at low pressure. This difference could be due to a collision-induced emission process at high pressure. The rate constants for the quenching by CO and H 2 were measured for the metastable state 3 P 2 (1,85 and 10,5 x 10 -11 cm 3 s -1 ) and for the resonant states 3 P 1 (4,5 and 20 x 10 -11 cm 3 s -1 ) and 1 P 1 (8,5 and 33 X 10 -11 cm 3 s -1 ). Comparison of the de-excitation cross sections of resonant and metastable states should lead to a better understanding of energy transfer processes from these latter. (author) [fr

49 CFR 260.7 - Priority consideration.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Priority consideration. 260.7 Section 260.7... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Overview § 260.7 Priority consideration. When evaluating applications, the Administrator will give priority consideration (but not necessarily in the following order...

Investigation of the reaction 16O(p,n)16F at Esub(p)=135 MeV

International Nuclear Information System (INIS)

Gareev, F.A.; Ershov, S.N.

1984-01-01

The 16 O(p,n) 16 F reaction at 135 MeV has been analyzed the framework of the distorted-wave impulse-approximation (DWIA). Both direct and exchange mechanisms of nucleon knock-out are taken into account. Including the n-particle n-hole (n=0, 1, 2) correlations in the wave functions of A=16 nuclei improves the description of experimental data: diminishes the absolute value of the cross sections about twice as compared with the calculations using the simple particle-hole structure models

1988 Delphi survey of nursing research priorities for New York State.

Science.gov (United States)

Shortridge, L; Doswell, W; Evans, M E; Levin, R F; Millor, G K; Carter, E

1989-09-01

In order to inform decisions about nursing research and health care policy, the Council on Nursing Research of the New York State Nurses Association (NYSNA) conducted a Delphi survey to identify the priorities for nursing research in New York state. The Delphi technique is a method of eliciting judgements from experts for the purpose of short-term forecasting and planning. The survey was conducted by mail in three rounds during 1988. Round I required participants to identify three primary research priorities for the nursing profession. In Round II participants ranked the 37 most frequently identified categories from Round I. The highest 16 categories from Round II were ranked by participants in Round III to provide the final 10 nursing research priority categories for New York state. All members of the New York State Nurses Association holding a minimum of a master's degree in nursing were invited to participate. The response rates were: Round I, 34% (N = 872); Round II, 38% (N = 985); Round III 37% (N = 974). Of the 10 nursing research priority categories identified in the final round, 5 relate to nurses, 2 relate to nursing, and 3 relate to clients. None of the high-risk conditions or populations with whom nurses work appear in the top 10, and only 2 of these are ranked in the top 15 priority categories. These priority categories will be used by the NYSNA Council on Nursing Research to influence its future agenda and activities. They can be used by the nursing profession and others for planning, policy making, and establishing nursing research funding priorities.(ABSTRACT TRUNCATED AT 250 WORDS)

15 CFR 16.10 - The Department of Commerce Mark.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false The Department of Commerce Mark. 16.10 Section 16.10 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY CONSUMER PRODUCT INFORMATION LABELING PROGRAM § 16.10 The Department of Commerce Mark. The Department of...

75 FR 74750 - In the Matter of Toshiba America Nuclear Energy Corporation and All Other Persons Who Seek or...

Science.gov (United States)

2010-12-01

... NUCLEAR REGULATORY COMMISSION [EA-10-152; Project No. 52-0001; NRC-2010-0368] In the Matter of Toshiba America Nuclear Energy Corporation and All Other Persons Who Seek or Obtain Access to Safeguards... protect SGI (73 FR 63546). The NRC is issuing this Order to Toshiba America Nuclear Energy Corporation...

Tallinna raearhiivi kasutamisest 16. sajandil / Juhan Kreem

Index Scriptorium Estoniae

Kreem, Juhan

2008-01-01

Esimene kogu arhiivi paiknemist ja olukorda iseloomustav tekst pärineb aastast 1840 Fr. G. von Bungelt. Käesoleva artikli autor vaatleb Tallinna raearhiivi kroonikakirjutajate seisukohast. Tallinna 16. sajandi olulised kroonikud olid Johan Gellinckhusen ja Balthasar Russow, kes mõlemad rõhutasid linna konfrontatsiooni aadelkonnaga. Vastavasisulise dokumentatsiooni kasutamisest kroonikute poolt nende tegutsemisajale eelnenud perioodist. Linna privileegide kajastamisest Russowi kroonikas

High-energy neutrinos from FR0 radio galaxies?

Science.gov (United States)

Tavecchio, F.; Righi, C.; Capetti, A.; Grandi, P.; Ghisellini, G.

2018-04-01

The sources responsible for the emission of high-energy (≳100 TeV) neutrinos detected by IceCube are still unknown. Among the possible candidates, active galactic nuclei with relativistic jets are often examined, since the outflowing plasma seems to offer the ideal environment to accelerate the required parent high-energy cosmic rays. The non-detection of single-point sources or - almost equivalently - the absence, in the IceCube events, of multiplets originating from the same sky position - constrains the cosmic density and the neutrino output of these sources, pointing to a numerous population of faint sources. Here we explore the possibility that FR0 radio galaxies, the population of compact sources recently identified in large radio and optical surveys and representing the bulk of radio-loud AGN population, can represent suitable candidates for neutrino emission. Modelling the spectral energy distribution of an FR0 radio galaxy recently associated with a γ-ray source detected by the Large Area Telescope onboard Fermi, we derive the physical parameters of its jet, in particular the power carried by it. We consider the possible mechanisms of neutrino production, concluding that pγ reactions in the jet between protons and ambient radiation is too inefficient to sustain the required output. We propose an alternative scenario, in which protons, accelerated in the jet, escape from it and diffuse in the host galaxy, producing neutrinos as a result of pp scattering with the interstellar gas, in strict analogy with the processes taking place in star-forming galaxies.

Two-neutron stripping in ({sup 18}O, {sup 16}O) and (t,p) reactions

Energy Technology Data Exchange (ETDEWEB)

Cavallaro, M.; Agodi, A.; Carbone, D.; Cunsolo, A. [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, I-95125 Catania (Italy); Bondì, M.; Cappuzzello, F.; Nicolosi, D.; Tropea, S. [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, I-95125 Catania, Italy and Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, I-95125 Catania (Italy); Borello-Lewin, T.; Rodrigues, M. R. D. [Instituto de Física - Universidade de São Paulo, Rua do Matão Travessa R Nr.187 CEP 05508-090 Cidade Universitária, São Paulo (Brazil); De Napoli, M. [INFN - Sezione di Catania, Via S. Sofia 64, I-95125 Catania (Italy); Garcia, V. N. [Instituto de Física, Universidade Federal Fluminense, Avenida Litoranea s/n, Gragoata, 24210-340, Niteroi, RJ (Brazil); Linares, R.; Lubian, J.; Paes, B. [Instituto de Física, Universidade Federal Fluminense, Avenida Litoranea s/n, Gragoata , 24210-340, Niteroi, RJ (Brazil); Foti, A. [Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, I-95125 Catania, Italy and INFN - Sezione di Catania, Via S. Sofia 64, I-95125 Catania (Italy)

2014-11-11

The {sup 12}C({sup 18}O,{sup 16}O){sup 14}C reactions has been investigated at 84 MeV incident energy. The charged ejectiles produced in the reaction have been momentum analyzed and identified by the MAGNEX magnetic spectrometer. Q-value spectra have been extracted with an energy resolution of 160 keV (Full Width at Half Maximum) and several known bound and resonant states of {sup 14}C have been identified up to 15 MeV. In particular, excited states with dominant 2p - 4h configuration are the most populated. The absolute values of the cross sections have been extracted showing a striking similarity with those measured for the same transitions by (t,p) reactions. This indicates that the effect of the {sup 16}O core is negligible in the reaction mechanism.

THE ORIGIN OF THE INFRARED EMISSION IN RADIO GALAXIES. II. ANALYSIS OF MID- TO FAR-INFRARED SPITZER OBSERVATIONS OF THE 2JY SAMPLE

NARCIS (Netherlands)

Dicken, D.; Tadhunter, C.; Axon, D.; Morganti, R.; Inskip, K. J.; Holt, J.; Delgado, R. Gonzalez; Groves, B.

2009-01-01

We present an analysis of deep mid- to far-infrared (MFIR) Spitzer photometric observations of the southern 2Jy sample of powerful radio sources (0.05

p16(INK4a translation suppressed by miR-24.

Directory of Open Access Journals (Sweden)

Ashish Lal

2008-03-01

Full Text Available Expression of the tumor suppressor p16(INK4a increases during aging and replicative senescence.Here, we report that the microRNA miR-24 suppresses p16 expression in human diploid fibroblasts and cervical carcinoma cells. Increased p16 expression with replicative senescence was associated with decreased levels of miR-24, a microRNA that was predicted to associate with the p16 mRNA coding and 3'-untranslated regions. Ectopic miR-24 overexpression reduced p16 protein but not p16 mRNA levels. Conversely, introduction of antisense (AS-miR-24 blocked miR-24 expression and markedly enhanced p16 protein levels, p16 translation, and the production of EGFP-p16 reporter bearing the miR-24 target recognition sites.Together, our results suggest that miR-24 represses the initiation and elongation phases of p16 translation.

Balancing development, energy and climate priorities in China. Current status and the way ahead

International Nuclear Information System (INIS)

Kejun Jiang; Xiulian Hu; Xianli Zhu; Garg, A.; Halsnaes, K.; Qiang Liu

2007-09-01

This report is the China Country Report of the project: Projecting future energy demand: Balancing development, energy and climate priorities in large developing economies. Under this project four country studies have been carried out, on China, India, Brazil, and South Africa respectively. The focus of this report is on the energy sector policies that mainstream climate interests within development choices. The report gives a short introduction to the project and its approach, followed by analyses of Chinese energy, development and climate change and an assessment of cross-country results that gives a range of key indicators of the relationship between economic growth, energy, and local and global pollutants. (BA)

16 CFR 307.10 - Cooperative advertising.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Cooperative advertising. 307.10 Section 307... REGULATIONS UNDER THE COMPREHENSIVE SMOKELESS TOBACCO HEALTH EDUCATION ACT OF 1986 Advertising Disclosures § 307.10 Cooperative advertising. The Act prohibits any manufacturer, packager, or importer of smokeless...

Contribution to the study of low-energy (d,p) reactions on light nuclei; Contribution a l'etude des reactions (d,p) a basse energie sur noyaux legers

Energy Technology Data Exchange (ETDEWEB)

Nguyen Van, S [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-05-15

This work is carried out with a view to analysing low energy (d,p) reactions on light nuclei measured at Grenoble or Algiers and suggesting a direct mechanism. The distorted wave approximation has been applied; this requires the development of programmes for the IBM 7044 computer at the 'Institut des Mathematiques Appliquees' in Grenoble. The (d,p) reactions on {sup 14}N, {sup 9}Be, {sup 22}Ne and {sup 16}O are dealt with. A calculation of the interference of the direct interaction and of resonating effects has been applied to {sup 16}O. (author) [French] Ce travail a pour but d'analyser les reactions (d,p) a basse energie sur noyaux legers, mesurees a Grenoble ou a Alger et qui suggerent un mecanisme direct. L'approximation des ondes distordues a ete appliquee, necessitant la mise au point de programmes sur l'ordinateur IBM 7044 de l'Institut des Mathematiques Appliquees de Grenoble. Des reactions (d,p) sur {sup 14}N, {sup 9}Be, {sup 22}Ne et {sup 16}O sont traitees. Un calcul de l'interference de l'interaction directe et des effets resonnants a ete applique a {sup 16}O. (auteur)

1991 Acceptance priority ranking

International Nuclear Information System (INIS)

1991-12-01

The Standard Contract for Disposal of Spent Nuclear Fuel and/or High- Level Radioactive Waste (10 CFR Part 961) that the Department of Energy (DOE) has executed with the owners and generators of civilian spent nuclear fuel requires annual publication of the Acceptance Priority Ranking (APR). The 1991 APR details the order in which DOE will allocate Federal waste acceptance capacity. As required by the Standard Contract, the ranking is based on the age of permanently discharged spent nuclear fuel (SNF), with the owners of the oldest SNF, on an industry-wide basis, given the highest priority. the 1991 APR will be the basis for the annual allocation of waste acceptance capacity to the Purchasers in the 1991 Annual Capacity Report (ACR), to be issued later this year. This document is based on SNF discharges as of December 31, 1990, and reflects Purchaser comments and corrections, as appropriate, to the draft APR issued on May 15, 1991

Introducing a Global Optical Model Approach for Analysing 16O+16O Elastic Scattering at 5-10MeV/nucleon Region

Directory of Open Access Journals (Sweden)

Mehmet Küçükoğlu

2013-06-01

Full Text Available Abstract: In this paper, the experimental data on elastic scattering of the 16O+16O reaction for the energy range 5-10 MeV/nucleon have been analyzed within the optical model (OM formalism by using the phenomenological potential forms in Fresco code. When developing the shape of the nuclear potential for the calculations, we have used the Woods-Saxon (WS or Woods-Saxon squared (WS2 potentials for the imaginary part together with a WS2 type real part. Although most of the previous OM analyses using phenomenological potentials have provided reasonably good fits with the experimental measurements, none of them could completely relate the behavior of the imaginary potential to the energy of the projectile yet. However, we have managed to introduce two analyses that can keep the real potential parameters almost constant and suggest a linear expression for the depth of the imaginary part of the nuclear potential depending on the incidence energy. Thus, 16O+16O system within this wide energy range has been described globally by the optical potentials having a deep, attractive real potential part and a weaker, energy dependent absorptive imaginary potential part. It has been also shown that, our calculations with these potential forms can reproduce the experimental elastic scattering angular distributions successfully and the maxima and minima are predicted correctly for most of the energies. Key words: 16O+16O reaction, optical model, elastic scattering, cross-section, phenomenological potentials. 5-10MeV/nükleon Bölgesinde 16O+16O Esnek Saçılmasının Analizi için Global bir Optik Model Yaklaşımının Tanıtılması Özet: Bu çalışmada 5-10 MeV/nükleon enerji aralığında 16O+16O reaksiyonunun deneysel esnek saçılma verileri, optik model (OM formalizmi altında, Fresco kodunda fenomenolojik potansiyel formları kullanılarak analiz edilmektedir. Hesaplamalar için nükleer potansiyelin şekli oluşturulurken gerçel kısım için Woods

High CpG island methylation ofp16 gene and loss of p16 protein ...

Indian Academy of Sciences (India)

Navya

:Tetralogy of Fallot;p16 gene;p16 protein;CpG islands;Methylation;Promoter regions ... of congenital heart disease, as well as the exclusion of previous history of ..... malignant progression of oral epithelial dysplasia: a prospective cohort study.

Priorities and strategies for the implementation of sustainable energy policy as seen by Japan

Energy Technology Data Exchange (ETDEWEB)

Nishizawa, Jun-ichi [Tohoku Univ., Sendai (Japan)

1995-12-31

The paper deals with priorities and strategies of energy policy in connection with power production combined with population rising. The global emission of carbon dioxide, is discussed in this connection. According to the author, the most suitable form of energy for generation, transportation, conversion and consumption, is electricity. Various types of energy resources together with the high voltage direct current transmission are dealt with. The efficiency of systems for power generation and transmission together with the conversion efficiency of different types of static induction thyristors, are discussed. 8 figs.

75 FR 5291 - Office of Special Education and Rehabilitative Services; Overview Information; Technology and...

Science.gov (United States)

2010-02-02

... DEPARTMENT OF EDUCATION Office of Special Education and Rehabilitative Services; Overview..., Assistant Secretary for Special Education and Rehabilitative Services. [FR Doc. 2010-2182 Filed 2-1-10; 8:45... the Individuals with Disabilities Education Act (IDEA)). Absolute Priority: For FY 2010 and any...

Interobserver reproducibility and accuracy of p16/Ki-67 dual-stain cytology in cervical cancer screening.

Science.gov (United States)

Wentzensen, Nicolas; Fetterman, Barbara; Tokugawa, Diane; Schiffman, Mark; Castle, Philip E; Wood, Shannon N; Stiemerling, Eric; Poitras, Nancy; Lorey, Thomas; Kinney, Walter

2014-12-01

Dual-stain cytology for p16 and Ki-67 has been proposed as a biomarker in cervical cancer screening. The authors evaluated the reproducibility and accuracy of dual-stain cytology among 10 newly trained evaluators. In total, 480 p16/Ki-67-stained slides from human papillomavirus-positive women were evaluated in masked fashion by 10 evaluators. None of the evaluators had previous experience with p16 or p16/Ki-67 cytology. All participants underwent p16/Ki-67 training and subsequent proficiency testing. Reproducibility of dual-stain cytology was measured using the percentage agreement, individual and aggregate κ values, as well as McNemar statistics. Clinical performance for the detection of cervical intraepithelial neoplasia grade 2 or greater (CIN2+) was evaluated for each individual evaluator and for all evaluators combined compared with the reference evaluation by a cytotechnologist who had extensive experience with dual-stain cytology. The percentage agreement of individual evaluators with the reference evaluation ranged from 83% to 91%, and the κ values ranged from 0.65 to 0.81. The combined κ value was 0.71 for all evaluators and 0.73 for cytotechnologists. The average sensitivity and specificity for the detection of CIN2+ among novice evaluators was 82% and 64%, respectively; whereas the reference evaluation had 84% sensitivity and 63% specificity, respectively. Agreement on dual-stain positivity increased with greater numbers of p16/Ki-67-positive cells on the slides. Good to excellent reproducibility of p16/Ki-67 dual-stain cytology was observed with almost identical clinical performance of novice evaluators compared with reference evaluations. The current findings suggest that p16/Ki-67 dual-stain evaluation can be implemented in routine cytology practice with limited training. © 2014 American Cancer Society.

Identifying conservation priorities and management strategies based on ecosystem services to improve urban sustainability in Harbin, China

Directory of Open Access Journals (Sweden)

Yi Qu

2018-04-01

Full Text Available Rapid urbanization and agricultural development has resulted in the degradation of ecosystems, while also negatively impacting ecosystem services (ES and urban sustainability. Identifying conservation priorities for ES and applying reasonable management strategies have been found to be effective methods for mitigating this phenomenon. The purpose of this study is to propose a comprehensive framework for identifying ES conservation priorities and associated management strategies for these planning areas. First, we incorporated 10 ES indicators within a systematic conservation planning (SCP methodology in order to identify ES conservation priorities with high irreplaceability values based on conservation target goals associated with the potential distribution of ES indicators. Next, we assessed the efficiency of the ES conservation priorities for meeting the designated conservation target goals. Finally, ES conservation priorities were clustered into groups using a K-means clustering analysis in an effort to identify the dominant ES per location before formulating management strategies. We effectively identified 12 ES priorities to best represent conservation target goals for the ES indicators. These 12 priorities had a total areal coverage of 13,364 km2 representing 25.16% of the study area. The 12 priorities were further clustered into five significantly different groups (p-values between groups < 0.05, which helped to refine management strategies formulated to best enhance ES across the study area. The proposed method allows conservation and management plans to easily adapt to a wide variety of quantitative ES target goals within urban and agricultural areas, thereby preventing urban and agriculture sprawl and guiding sustainable urban development.

Importance of the energy-dependent geometry in the 16O+ 16O optical model potential

International Nuclear Information System (INIS)

Pantis, G.; Ioannidis, K.; Poirier, P.

1985-01-01

Optical model potentials with various forms of energy-dependent geometry have been considered for the description of 16 O+ 16 O elastic scattering. It is shown that the variation with energy of the imaginary radius leads to a reasonable fit of the cross-section data, throughout the energy range

76 FR 53119 - High Energy Physics Advisory Panel

Science.gov (United States)

2011-08-25

... DEPARTMENT OF ENERGY High Energy Physics Advisory Panel AGENCY: Department of Energy. ACTION... hereby given that the High Energy Physics Advisory Panel will be renewed for a two-year period, beginning...-range planning and priorities in the national High Energy Physics program. Additionally, the renewal of...

f(R in Holographic and Agegraphic Dark Energy Models and the Generalized Uncertainty Principle

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Barun Majumder

2013-01-01

Full Text Available We studied a unified approach with the holographic, new agegraphic, and f(R dark energy model to construct the form of f(R which in general is responsible for the curvature driven explanation of the very early inflation along with presently observed late time acceleration. We considered the generalized uncertainty principle in our approach which incorporated the corrections in the entropy-area relation and thereby modified the energy densities for the cosmological dark energy models considered. We found that holographic and new agegraphic f(R gravity models can behave like phantom or quintessence models in the spatially flat FRW universe. We also found a distinct term in the form of f(R which goes as R 3 / 2 due to the consideration of the GUP modified energy densities. Although the presence of this term in the action can be important in explaining the early inflationary scenario, Capozziello et al. recently showed that f(R ~ R 3 / 2 leads to an accelerated expansion, that is, a negative value for the deceleration parameter q which fits well with SNeIa and WMAP data.

Simulation of Different Truncated p16INK4a Forms and In Silico Study of Interaction with Cdk4

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Najmeh Fahham

2009-01-01

Full Text Available Protein-protein interactions studies can greatly increase the amount of structural and functional information pertaining to biologically active molecules and processes. The information obtained from such studies can lead to design and application of new modification in order to obtain a desired bioactivity. Many application packages and servers performing docking, such as HEX, DOT, AUTODOCK, and ZDOCK are now available for predicting the lowest free energy state of a protein complex. In this study, we have focused on cyclin-dependent kinase 4 (Cdk4, a key molecule in the regulation of cell cycle progression at the G1-S phase restriction point and p16INK4a, a tumor suppressor which inhibits Cdk4 activity. Truncated structures were created to find the more critical regions of p16 for interaction. The tertiary structures were determined by ProSAL, GENO3D Web Server. We evaluated their interactions with Cdk4 using two docking systems, HEX 4.5 and DOT 1. Calculations were performed on a high-speed computer. Minimizations and visualizations were carried out by PdbViewer 3.7. Considering shape and shape/electrostatic total energy, structures containing ANK II, III and IV motifs that lack the N-terminal region of the full length p16 molecule showed the best fi t complexes among the p16 truncated forms. The free energies were compatible with that of p16 full length original form, the full length. It seems that the N-terminal of the molecule is not crucial for the interaction since the truncated structure containing only this region did not show a good total energy.

Sirenomelia with a de novo balanced translocation 46,X,t(X;16)(p11.23;p12.3).

Science.gov (United States)

Kurosawa, Kenji; Tanoshima-Takei, Miki; Yamamoto, Toshiyuki; Ishikawa, Hiroshi; Masuno, Mitsuo; Tanaka, Yukichi; Yamanaka, Michiko

2012-06-01

We report a female fetus with sirenomelia with 46,X,t(X;16)(p11.23;p12.3) de novo. Fluorescence in situ hybridization (FISH) with bacterial artificial chromosomes were employed for narrowing down the breakpoint regions. On chromosome 16, the breakpoint was mapped in the region of RP11-453F10 (19 920 640-20 118 153 bp from 16pter). On chromosome X, the breakpoint was mapped in the region of RP11-794A15 (47 333 744-47 524 066 bp from Xpter). This is the first case report of sirenomelia associated with translocations. The abnormal phenotype, associated with a balanced translocation, was caused by deletion or breakage of dosage-sensitive genes of the breakpoint, disruption of an imprinted gene, or uniparental disomy. Although the parental origin of normal 16 and der(16) remained undetermined, this case will provide insight into the pathogenetic mechanism of sirenomelia. © 2011 The Authors. Congenital Anomalies © 2011 Japanese Teratology Society.

25 CFR 542.16 - What are the minimum internal control standards for information technology?

Science.gov (United States)

2010-04-01

... information technology? 542.16 Section 542.16 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE... standards for information technology? Link to an amendment published at 73 FR 60498, Oct. 10, 2008. This... adequately segregated and monitored to prevent error in general information technology procedures to go...

78 FR 50405 - High Energy Physics Advisory Panel

Science.gov (United States)

2013-08-19

... DEPARTMENT OF ENERGY High Energy Physics Advisory Panel AGENCY: Office of Science, Department of..., General Services Administration, notice is hereby given that the High Energy Physics Advisory Panel will... Sciences Directorate (NSF), on long-range planning and priorities in the national high-energy physics...

Identifying priorities in methodological research using ICD-9-CM and ICD-10 administrative data: report from an international consortium

Directory of Open Access Journals (Sweden)

Ma Jin

2006-06-01

Full Text Available Abstract Background Health administrative data are frequently used for health services and population health research. Comparative research using these data has been facilitated by the use of a standard system for coding diagnoses, the International Classification of Diseases (ICD. Research using the data must deal with data quality and validity limitations which arise because the data are not created for research purposes. This paper presents a list of high-priority methodological areas for researchers using health administrative data. Methods A group of researchers and users of health administrative data from Canada, the United States, Switzerland, Australia, China and the United Kingdom came together in June 2005 in Banff, Canada to discuss and identify high-priority methodological research areas. The generation of ideas for research focussed not only on matters relating to the use of administrative data in health services and population health research, but also on the challenges created in transitioning from ICD-9 to ICD-10. After the brain-storming session, voting took place to rank-order the suggested projects. Participants were asked to rate the importance of each project from 1 (low priority to 10 (high priority. Average ranks were computed to prioritise the projects. Results Thirteen potential areas of research were identified, some of which represented preparatory work rather than research per se. The three most highly ranked priorities were the documentation of data fields in each country's hospital administrative data (average score 8.4, the translation of patient safety indicators from ICD-9 to ICD-10 (average score 8.0, and the development and validation of algorithms to verify the logic and internal consistency of coding in hospital abstract data (average score 7.0. Conclusion The group discussions resulted in a list of expert views on critical international priorities for future methodological research relating to health

75 FR 17036 - Energy Conservation Program: Energy Conservation Standards for Small Electric Motors; Correction

Science.gov (United States)

2010-04-05

... Conservation Program: Energy Conservation Standards for Small Electric Motors; Correction AGENCY: Office of... standards for small electric motors, which was published on March 9, 2010. In that final rule, the U.S... titled ``Energy Conservation Standards for Small Electric Motors.'' 75 FR 10874. Since the publication of...

10 CFR 440.1 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 440.1 Section 440.1 Energy DEPARTMENT... scope. This part implements a weatherization assistance program to increase the energy efficiency of... with children, high residential energy users, and households with high energy burden. [65 FR 77217, Dec...

A new study of {sup 10}B(p,α){sup 7}Be reaction at low energies

Energy Technology Data Exchange (ETDEWEB)

Caciolli, A.; Depalo, R. [Universita di Padova, Dipartimento di Fisica e Astronomia, Padova (Italy); INFN, Sezione di Padova, Padova (Italy); Broggini, C.; Menegazzo, R. [INFN, Sezione di Padova, Padova (Italy); La Cognata, M.; Puglia, S.M.R.; Sergi, M.L. [Laboratori Nazionali del Sud, INFN, Catania (Italy); Lamia, L. [Universita degli Studi di Catania, Dipartimento di Fisica e Astronomia, Catania (Italy); Mou, L.; Rigato, V.; Rossi Alvarez, C. [Laboratori Nazionali di Legnaro, INFN, Legnaro (Italy); Romano, S.; Spitaleri, C. [Laboratori Nazionali del Sud, INFN, Catania (Italy); Universita degli Studi di Catania, Dipartimento di Fisica e Astronomia, Catania (Italy); Tumino, A. [Laboratori Nazionali del Sud, INFN, Catania (Italy); Universita degli Studi di Enna ' ' Kore' ' , Facolta di Ingegneria e Architettura, Enna (Italy)

2016-05-15

The {sup 10}B(p,α){sup 7}Be reaction is of great interest since it has many applications in different fields of research such as nuclear astrophysics, nuclear physics, and models of new reactors for clean energy generation. This reaction has been studied at the AN2000 accelerator of the INFN National Laboratories of Legnaro (LNL). The total cross section has been measured in a wide energy range (250-1182 keV) by using the activation method. The decays of the {sup 7}Be nuclei produced by the reaction were measured at the low counting facility of LNL by using two fully shielded high-purity germanium detectors. The present dataset shows a large discrepancy with respect to one of the previous data at the same energies and reduces the total uncertainty to the level of 6%. An R-matrix calculation has been performed on the present data using the parameters from previous Trojan Horse measurements for the 10 and 500 keV resonances. The present data do not lay on the R-matrix fit in one point suggesting the existence of a {sup 11}C level not observed yet. Further nuclear investigations are needed to confirm this hypothesis. (orig.)

10 CFR 1017.29 - Civil penalty.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Civil penalty. 1017.29 Section 1017.29 Energy DEPARTMENT... INFORMATION Violations § 1017.29 Civil penalty. Link to an amendment published at 74 FR 66033, Dec. 14, 2009... subject to a civil penalty under this part: (1) 10 CFR Part 1017—Identification and Protection of...

High CpG island methylation of p16 gene and loss of p16 protein ...

Indian Academy of Sciences (India)

SI-JU GAO

abnormality or family history of congenital heart disease, as well as the exclusion of ... Germany) according to the manufacture's protocol. A total of. 45 μL of DNA was ... islands and the primer sites are illustrated in figure 1. Detection of p16 ...

Impact of 9p deletion and p16, Cyclin D1, and Myc hyperexpression on the outcome of anaplastic oligodendrogliomas.

Directory of Open Access Journals (Sweden)

Karine Michaud

Full Text Available To study the presence of 9p deletion and p16, cyclin D1 and Myc expression and their respective diagnostic and prognostic interest in oligodendrogliomas.We analyzed a retrospective series of 40 consecutive anaplastic oligodendrogliomas (OIII from a single institution and compared them to a control series of 10 low grade oligodendrogliomas (OII. Automated FISH analysis of chromosome 9p status and immunohistochemistry for p16, cyclin D1 and Myc was performed for all cases and correlated with clinical and histological data, event free survival (EFS and overall survival (OS.Chromosome 9p deletion was observed in 55% of OIII (22/40 but not in OII. Deletion was highly correlated to EFS (median = 29 versus 53 months, p<0.0001 and OS (median = 48 versus 83 months, p<0.0001 in both the total cohort and the OIII population. In 9p non-deleted oligodendrogliomas, p16 hyperexpression correlated with a shorter OS (p = 0.02 in OII and p = 0.0001 in OIII whereas lack of p16 expression was correlated to a shorter EFS and OS in 9p deleted OIII (p = 0.001 and p = 0.0002 respectively. Expression of Cyclin D1 was significantly higher in OIII (median expression 45% versus 14% for OII, p = 0.0006 and was correlated with MIB-1 expression (p<0.0001, vascular proliferation (p = 0.002, tumor necrosis (p = 0.04 and a shorter EFS in the total cohort (p = 0.05. Hyperexpression of Myc was correlated to grade (median expression 27% in OII versus 35% in OIII, p = 0.03, and to a shorter EFS in 9p non-deleted OIII (p = 0.01.Chromosome 9p deletion identifies a subset of OIII with significantly worse prognosis. The combination of 9p status and p16 expression level identifies two distinct OIII populations with divergent prognosis. Hyperexpression of Bcl1 and Myc appears highly linked to anaplasia but the prognostic value is unclear and should be investigated further.

78 FR 61348 - Environmental Management Site-Specific Advisory Board, Portsmouth

Science.gov (United States)

2013-10-03

...On September 16, 2013, in FR Doc. 2013-22453, on page 56871, the Department of Energy (DOE) published a notice of open meeting announcing a meeting on October 2, 2013 of the Environmental Management Site-Specific Advisory Board, Portsmouth (78 FR 56871). This notice announces the cancellation of this meeting.

16 CFR 803.10 - Running of time.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Running of time. 803.10 Section 803.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 TRANSMITTAL RULES § 803.10 Running of time. (a...

Liberalization of the energy market in the Republic of Bulgaria - the main priority of the SAEER

International Nuclear Information System (INIS)

Kovachev, M.

2001-01-01

The priorities in the policy of the Bulgarian State Agency of Energetics and Energy Regulation, taking into account the current situation in the country, are presented. The main topics, discussed are: 1) Development of a competitive energy market; 2) Harmonization of the legislation with the European Union; 3) Bringing investments into the energetics and privatization; 4) Energy supply at minimal expenses; 5) Energy efficiency; 6) Encouraging of the use of renewable energy sources; 7) Integration of the Bulgarian and European energy market; Assurance of nuclear safety and the safe management of radioactive waste and spent fuel

Alpha decay 225 Ac → 221Fr

International Nuclear Information System (INIS)

Gromov, K. Ya.; Gorozhankin, V.M.; Malov, L.A.; Fominykh, V.I.; Tsupko-Sitnikov, V.V.; Chumin, V.G.; Jakushev, E.A.; Kudrya, S.A.; Sergienko, V.A.; Malikov, Sh.R.

2004-01-01

Full text: Considerable attention has been given to nuclei with A = 220 - 230 recently. In this region there occurs transition from the spherical to the deformed nuclear shape, which gives rise to some specific features in the nuclear structure. In particular, negative parity levels with low excitation energies have been found in even-even nuclei from this region [1, 2]. One of the nuclei allowing experimental investigation of the above properties is 221 Fr. The nuclide 221 Fr is from the region of isotopes which does not include stable nuclei and thus it cannot be studied in several-nucleon transfer reactions. In addition, the neutron excess in this nucleus makes it impossible to study the nucleus in reactions with heavy ions. Experimental information on the 221 Fr level structure can only be gained from investigation of the 225 Ac (T 1/2 = 10 days) alpha decay or the 221 Rn (T 1/2 = 25 min) beta decay. In the latter case the possibilities of the investigation are restricted by difficulties in making of 221 Rn sources. Therefore, most information on the structure and properties of 221 Fr is derived from investigation of the 225 Ac α -decay [3]. In-depth investigation of ( α - γ )- coincidences at the 225 Ac decay is carried out. Twenty-one new weak γ - rays are found; 18 γ-rays earlier ascribed to the 225 Ac decay are not confirmed. The quantitative analysis of the ( α - γ )- coincidences makes it possible to find the intensity of 221 Fr levels by the decay and multipolarities of five weak γ -transitions. The conversion electron spectrum is investigated in the range of 5 † 24 keV with a high (some 20 eV) energy resolution. A new M1 type 10.6-keV γ-transition is found. The proposed 225 Ac decay scheme includes 31 excited 221 Fr states. Parities are established for 16 of them. Possible spin values are proposed for 221 Fr levels. Properties of excited 221 Fr states are satisfactorily described by the quasiparticle-phonon nuclear model without the

Diagnostic value of progesterone receptor, p16, p53 and pHH3 expression in uterine atypical leiomyoma.

Science.gov (United States)

Liang, Yun; Zhang, Xiaofei; Chen, Xiaoduan; Lü, Weiguo

2015-01-01

The differential diagnosis between atypical leiomyoma and leiomyosarcoma may be hard based on morphological criterion at times. It would be helpful to find out biomarkers that can be used to distinguish them. The aim of the study was to investigate the diagnostic value of progesterone receptor (PR), p16, p53 and pHH3 expression in a series of uterine smooth muscle tumors. Immunohistochemical expression of PR, p16, p53 and pHH3 was investigated on 32 atypical leiomyomas, 15 leiomyosarcomas and 15 usual leomyomas. The difference in expression was compared between atypical leiomyoma and other groups. The expression of PR, p16, and pHH3 was found significantly different between atypical leiomyomas and leiomyosarcomas, but lack of significant difference between atypical leiomyomas and usual leiomyomas. There was no significant difference with regard to p53 distribution among these uterine smooth muscle tumors. High p16, pHH3 expression and low PR expression preferred the diagnosis of leiomyosarcoma. The panel of antibodies used in this study is a useful complementary analysis in the assessment of problematic uterine smooth muscle tumors.

77 FR 12280 - FFP Missouri 17, LLC BOST2 Hydroelectric, LLC; Notice Announcing Filing Priority for Preliminary...

Science.gov (United States)

2012-02-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project Nos. 13824-000, 13826-000] FFP Missouri 17, LLC BOST2 Hydroelectric, LLC; Notice Announcing Filing Priority for Preliminary Permit... Hydroelectric, LLC, Project No. 13826-000. 2. FFP Missouri 17, LLC, Project No. 13824-000. Dated: February 22...

Setting research priorities for Type 1 diabetes.

Science.gov (United States)

Gadsby, R; Snow, R; Daly, A C; Crowe, S; Matyka, K; Hall, B; Petrie, J

2012-10-01

Research priorities are often set by academic researchers or the pharmaceutical industry. The interests of patients, carers and clinicians may therefore be overlooked and research questions that matter may be neglected. The aims of this study were to collect uncertainties about the treatment of Type 1 diabetes from patients, carers and health professionals, and to collate and prioritize these uncertainties to develop a top 10 list of research priorities, using a structured priority-setting partnership of patients, carers, health professionals and diabetes organizations, as described by the James Lind Alliance. A partnership of interested organizations was set up, and from this a steering committee of 10 individuals was formed. An online and paper survey was used to identify uncertainties. These were collated, and the steering group carried out an interim priority-setting exercise with partner organizations. This group of uncertainties was then voted on to give a smaller list that went forward to the final priority-setting workshop. At this meeting, a final list of the top 10 research priorities was agreed. An initial 1141 uncertainties were described. These were reduced to 88 indicative questions, 47 of which went out for voting. Twenty-four were then taken forward to a final priority-setting workshop. This workshop resulted in a list of top 10 research priorities in Type 1 diabetes. We have shown that it is possible using the James Lind Alliance process to develop an agreed top 10 list of research priorities for Type 1 diabetes from health professionals, patients and carers. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.

Contribution to the study of low-energy (d,p) reactions on light nuclei; Contribution a l'etude des reactions (d,p) a basse energie sur noyaux legers

Energy Technology Data Exchange (ETDEWEB)

Nguyen Van, S. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-05-15

This work is carried out with a view to analysing low energy (d,p) reactions on light nuclei measured at Grenoble or Algiers and suggesting a direct mechanism. The distorted wave approximation has been applied; this requires the development of programmes for the IBM 7044 computer at the 'Institut des Mathematiques Appliquees' in Grenoble. The (d,p) reactions on {sup 14}N, {sup 9}Be, {sup 22}Ne and {sup 16}O are dealt with. A calculation of the interference of the direct interaction and of resonating effects has been applied to {sup 16}O. (author) [French] Ce travail a pour but d'analyser les reactions (d,p) a basse energie sur noyaux legers, mesurees a Grenoble ou a Alger et qui suggerent un mecanisme direct. L'approximation des ondes distordues a ete appliquee, necessitant la mise au point de programmes sur l'ordinateur IBM 7044 de l'Institut des Mathematiques Appliquees de Grenoble. Des reactions (d,p) sur {sup 14}N, {sup 9}Be, {sup 22}Ne et {sup 16}O sont traitees. Un calcul de l'interference de l'interaction directe et des effets resonnants a ete applique a {sup 16}O. (auteur)

New experimental investigation of cluster structures in 10 Be and 16 C neutron-rich nuclei

Science.gov (United States)

Dell'Aquila, L.; Acosta, D.; Auditore, L.; Cardella, G.; De Filippo, E.; De Luca, S.; Francalanza, L.; Gnoffo, B.; Lanzalone, G.; Lombardo, I.; Martorana, N. S.; Norella, S.; Pagano, A.; Pagano, E. V.; Papa, M.; Pirrone, S.; Politi, G.; Quattrocchi, L.; Rizzo, F.; Russotto, P.; Trifirò, A.; Trimarchi, M.; Verde, G.; Vigilante, M.

2017-11-01

The existence of cluster structures in ^{10} Be and ^{16} C neutron-rich isotopes is investigated via projectile break-up reactions induced on polyethylene (CH _2 target. We used a fragmentation beam constituted by 55MeV/u ^{10} Be and 49MeV/u ^{16} C beams provided by the FRIBs facility at INFN-LNS. Invariant mass spectra of 4{He}+ 6 He and 6{He} + ^{10} Be breakup fragments are reconstructed by means of the CHIMERA 4π detector to investigate the presence of excited states of projectile nuclei characterized by cluster structure. In the first case, we suggest the presence of a new state in ^{10} Be at 13.5MeV. A non-vanishing yield corresponding to 20.6MeV excitation energy of ^{16} C was observed in the 6{He} + ^{10} Be cluster decay channel. To improve the results of the present analysis, a new experiment has been performed recently, taking advantage of the coupling of CHIMERA and FARCOS. In the paper we describe the data reduction process of the new experiment together with preliminary results.

Mental health provision in schools: priority, facilitators and barriers in 10 European countries

OpenAIRE

Patalay, P.; Giese, L.; Stanković, M.; Curtin, C.; Moltrecht, B.; Gondek, D.

2016-01-01

Background: Although schools are a key setting for the provision of mental health support for young people, little is known about the facilitators and barriers for providing such support. This study aimed to collect information from schools in 10 European countries regarding the priority given to mental health support for students, existence of a mental health-related school policy, links with relevant external agencies, schools’ perceptions on whether they are providing sufficient mental hea...

16 CFR 1507.10 - Rockets with sticks.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Rockets with sticks. 1507.10 Section 1507.10... FIREWORKS DEVICES § 1507.10 Rockets with sticks. Rockets with sticks (including skyrockets and bottle rockets) shall utilize a straight and rigid stick to provide a direct and stable flight. Such sticks shall...

p16 mutation spectrum in the premalignant condition Barrett's esophagus.

Directory of Open Access Journals (Sweden)

Thomas G Paulson

Full Text Available BACKGROUND: Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions. METHODS AND FINDINGS: We have determined the p16 mutation spectrum for a cohort of 304 patients with Barrett's esophagus, a premalignant condition that predisposes to the development of esophageal adenocarcinoma. Forty seven mutations were detected by sequencing of p16 exon 2 in 44 BE patients (14.5% with a mutation spectrum consistent with that caused by oxidative damage and chronic inflammation. The percentage of patients with p16 mutations increased with increasing histologic grade. In addition, samples from 3 out of 19 patients (15.8% who underwent esophagectomy were found to have mutations. CONCLUSIONS: The results of this study suggest the environment of the esophagus in BE patients can both generate and select for clones with p16 mutations.

Securing energy efficiency as a high priority. Scenarios for common appliance electricity consumption in Thailand

Energy Technology Data Exchange (ETDEWEB)

Foran, T. [Unit for Social and Environmental Research USER, Faculty of Social Sciences, Chiang Mai University, P.O. Box 144, Chiang Mai, 50200 (Thailand); Du Pont, P.T. [International Resources Group and Joint Graduate School of Energy and Environment, Bangkok (Thailand); Parinya, P. [The Joint Graduate School of Energy and Environment, King Mongkut' s University of Technology Thonburi, Bangkok (Thailand); Phumaraphand, N. [Electricity Generating Authority of Thailand, Nonthaburi (Thailand)

2010-11-15

Between 1995 and 2008, Thailand's energy efficiency programs produced an estimated total of 8,369 GWh/year energy savings and 1,471 MW avoided peak power. Despite these impressive saving figures, relatively little future scenario analysis is available to policy makers. Before the 2008 global financial crisis, electricity planners forecasted 5-6% long-term increases in demand. We explored options for efficiency improvements in Thailand's residential sector, which consumes more than 20% of Thailand's total electricity consumption of 150 TWh/year. We constructed baseline and efficient scenarios for the period 2006-2026, for air conditioners, refrigerators, fans, rice cookers, and compact fluorescent light bulbs. We drew on an appliance database maintained by Electricity Generating Authority of Thailand's voluntary labeling program. For the five appliances modeled, the efficiency scenario results in total savings of 12% of baseline consumption after 10 years and 29% of baseline after 20 years. Approximately 80% of savings come from more stringent standards for air conditioners, including phasing out unregulated air conditioner sales within 6 years. Shifting appliance efficiency standards to current best-in-market levels within 6 years produces additional savings. We discuss institutional aspects of energy planning in Thailand that thus far have limited the consideration of energy efficiency as a high-priority resource.

FR4-based electromagnetic energy harvester for wireless sensor nodes

Science.gov (United States)

Hatipoglu, G.; Ürey, H.

2010-01-01

Electromagnetic (EM) energy harvesting seems to be one of the most promising ways to power wireless sensors in a wireless sensor network. In this paper, FR4, the most commonly used PCB material, is utilized as a mechanical vibrating structure for EM energy harvesting for body-worn sensors and intelligent tire sensors, which involve impact loadings. FR4 can be a better material for such applications compared to silicon MEMS devices due to lower stiffness and broadband response. In order to demonstrate FR4 performance and broadband response, three moving magnet type EM generator designs are developed and investigated throughout the paper. A velocity-damped harvester simulation model is first developed, including a detailed magnetic model and the magnetic damping effects. The numerical results agree well with the experimental results. Human running acceleration at the hip area that is obtained experimentally is simulated in order to demonstrate system performance, which results in a scavenged power of about 40 µW with 15 m s-2 acceleration input. The designed FR4 energy scavengers with mechanical stoppers implemented are particularly well suited for nearly periodic and non-sinusoidal high- g excitations with rich harmonic content. For the intelligent tire applications, a special compact FR4 scavenger is designed that is able to withstand large shocks and vibrations due to mechanical shock stoppers built into the structure. Using our design, 0.4 mW power across a load resistance at off-resonance operation is obtained in shaker experiments. In the actual operation, the tangential accelerations as a result of the tire-road contact are estimated to supply power around 1 mW with our design, which is sufficient for powering wireless tire sensors. The normalized power density (NPD) of the designed actuators compares favorably with most actuators reported in the literature.

FR4-based electromagnetic energy harvester for wireless sensor nodes

International Nuclear Information System (INIS)

Hatipoglu, G; Ürey, H

2010-01-01

Electromagnetic (EM) energy harvesting seems to be one of the most promising ways to power wireless sensors in a wireless sensor network. In this paper, FR4, the most commonly used PCB material, is utilized as a mechanical vibrating structure for EM energy harvesting for body-worn sensors and intelligent tire sensors, which involve impact loadings. FR4 can be a better material for such applications compared to silicon MEMS devices due to lower stiffness and broadband response. In order to demonstrate FR4 performance and broadband response, three moving magnet type EM generator designs are developed and investigated throughout the paper. A velocity-damped harvester simulation model is first developed, including a detailed magnetic model and the magnetic damping effects. The numerical results agree well with the experimental results. Human running acceleration at the hip area that is obtained experimentally is simulated in order to demonstrate system performance, which results in a scavenged power of about 40 µW with 15 m s −2 acceleration input. The designed FR4 energy scavengers with mechanical stoppers implemented are particularly well suited for nearly periodic and non-sinusoidal high- g excitations with rich harmonic content. For the intelligent tire applications, a special compact FR4 scavenger is designed that is able to withstand large shocks and vibrations due to mechanical shock stoppers built into the structure. Using our design, 0.4 mW power across a load resistance at off-resonance operation is obtained in shaker experiments. In the actual operation, the tangential accelerations as a result of the tire–road contact are estimated to supply power around 1 mW with our design, which is sufficient for powering wireless tire sensors. The normalized power density (NPD) of the designed actuators compares favorably with most actuators reported in the literature

A phantom for assessing the personal dose equivalent, H{sub P}(10); Um fantoma para a avaliacao do equivalente de dose pessoal, H{sub P}(10).

Energy Technology Data Exchange (ETDEWEB)

Santoro, C.; Filho, J.A [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Departamento de Energia Nuclear; Santos, M.A.P.; Filho, L.C.G., E-mail: chsantoro@gmail.com, E-mail: masantos@cnen.gov.br, E-mail: l.filho@cnen.gov.br, E-mail: jaf@ufpe.br [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil)

2013-10-15

Characteristics of a phantom designed to evaluate the personal dose equivalent, H{sub P}(10), and appropriate for photographic dosimetry are presented. It is called HP(10) phantom due to cavities constructed to insert dosimetric films at a depth of 10 mm. The H{sub P}(10) phantom is irradiated with ionizing radiation energy, E, from 45 to 1250 keV, with doses ranging from 0.2 to 50 mSv. It is positioned in the direction α = 0 °, and the radiation field focusing perpendicular to its front surface. So, are established calibration curves of dosimeters in the position conventionally true and quantities H{sub P}(10). It made a comparison between the responses obtained with the H{sub P}(10) phantom and responses obtained when using the calibration procedure recommended by ISO dosimeters. The ISO recommends getting the air kerma, Ka, for photons at test point of the radiation field by an ionization chamber. And through conversion coefficients, h{sub pK} (10; E, α), becomes the air kerma for H{sub P}(10). The ISO 4037-3 recommendation has been studied by researchers to ensure that the low energy spectral differences occur in radiation fields which are generated by various X-ray equipment, and induce changes in the percentages of conversion coefficients on the order of 10% to 90% . On the basis of the recommendations ISO, this article develops phantom able to assess the dose to the influence of scattering and absorption of radiation, its implications with respect to dosimetry, providing improvement in the assessment of doses. (author)

Research in the field of energy: the priorities of framework programme V and the main trends of the new framework programme

International Nuclear Information System (INIS)

Pilavachi, P.

2001-01-01

The features and priorities of the 5th European Framework Programme are discussed. The first action include quality of life and management of living resources; user friendly information society; competitive and sustainable growth and energy, environment and sustainable development (environment, energy and nuclear energy). The key actions are as follows: for environment - sustainable management and quality of water, global change, climate and biodiversity, sustainable marine ecosystems; for energy - cleaner energy systems, including renewable, economic efficient energy; for nuclear energy - controlled thermonuclear fusion, nuclear fission. The priorities of strategic importance to the EU are management of greenhouse gases emissions and climate change; exploiting of the potential of new ICTs in energy RTD including e-science issues; socio-economic research related to energy technologies and their impact; international co-operation, co-ordination with MS research programmes and EU wide research networks; pre-normative research of interest at EU level

Limits to source counts and cosmic microwave background fluctuations at 10.6 GHz

International Nuclear Information System (INIS)

Seielstad, G.A.; Masson, C.R.; Berge, G.L.

1981-01-01

We have determined the distribution of deflections due to sky temperature fluctuations at 10.6 GHz. If all the deflections are due to fine structure in the cosmic microwave background, we limit these fluctuations to ΔT/T -4 on an angular scale of 11 arcmin. If, on the other hand, all the deflections are due to confusion among discrete radio sources, the areal density of these sources is calculated for various slopes of the differential source count relationship and for various cutoff flux densities. If, for example, the slope is 2.1 and the cutoff is 10 mJy, we find (0.25--3.3) 10 6 sources sr -1 Jy -1

75 FR 6112 - Approval and Promulgation of Air Quality Implementation Plans; Georgia: Update to Materials...

Science.gov (United States)

2010-02-08

...) Incinerators........ 6/15/98 12/2/99, 64 FR 67491 391-3-1-.02(2)(d) Fuel-burning 1/17/79 9/18/79, 44 FR 54047...-.02(2)(aa) VOC Emissions from 1/9/91 10/13/92, 57 FR 46780 Wire Coating. 391-3-1-.02(2)(bb) Petroleum...)(lll) NOX Emissions from 2/16/00 7/10/01, 66 FR 35906 Fuel-burning Equipment. 391-3-1-.02(2)(mmm) NOX...

Adaptive Priority-Based Downlink Scheduling for WiMAX Networks

OpenAIRE

Wu, Shih-Jung; Huang, Shih-Yi; Huang, Kuo-Feng

2012-01-01

Supporting quality of service (QoS) guarantees for diverse multimedia services are the primary concerns for WiMAX (IEEE 802.16) networks. A scheduling scheme that satisfies QoS requirements has become more important for wireless communications. We propose a downlink scheduling scheme called adaptive priority-based downlink scheduling (APDS) for providing QoS guarantees in IEEE 802.16 networks. APDS comprises two major components: priority assignment and resource allocation. Different service-...

78 FR 29785 - Priority Mail Pricing

Science.gov (United States)

2013-05-21

... POSTAL REGULATORY COMMISSION [Docket No. R2013-7; Order No. 1714] Priority Mail Pricing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recently-filed Postal... that after the price change, the unused pricing authority available for the Special Services class will...

Synthesis of polydopamine-functionalized magnetic graphene and carbon nanotubes hybrid nanocomposites as an adsorbent for the fast determination of 16 priority polycyclic aromatic hydrocarbons in aqueous samples.

Science.gov (United States)

Chen, Kun; Jin, Rongrong; Luo, Chen; Song, Guoxin; Hu, Yaoming; Cheng, Hefa

2018-04-01

A novel adsorbent made of polydopamine-functionalized magnetic graphene and carbon nanotubes hybrid nanocomposite was synthesized and applied to determine 16 priority polycyclic aromatic hydrocarbons by magnetic solid phase extraction in water samples. FTIR spectroscopy, transmission electron microscopy, scanning electron microscopy, and Raman spectroscopy consistently indicate that the synthesized adsorbents are made of core-shell nanoparticles well dispersed on the surface of graphene and carbon nanotubes. The major factors affecting the extraction efficiency, including the pH value of samples, the amount of adsorbent, adsorption time and desorption time, type and volume of desorption solvent, were systematically optimized. Under the optimum extraction conditions, a linear response was obtained for polycyclic aromatic hydrocarbons between concentrations of 10 and 500 ng/L with the correlation coefficients ranging from 0.9958 to 0.9989, and the limits of detection (S/N = 3) were between 0.1 and 3.0 ng/L. Satisfactory results were also obtained when applying these magnetic graphene/carbon nanotubes/polydopamine hybrid nanocomposites to detect polycyclic aromatic hydrocarbons in several environmental aqueous samples. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

10C survey of radio sources at 15.7 GHz - II. First results

Science.gov (United States)

AMI Consortium; Davies, Mathhew L.; Franzen, Thomas M. O.; Waldram, Elizabeth M.; Grainge, Keith J. B.; Hobson, Michael P.; Hurley-Walker, Natasha; Lasenby, Anthony; Olamaie, Malak; Pooley, Guy G.; Riley, Julia M.; Rodríguez-Gonzálvez, Carmen; Saunders, Richard D. E.; Scaife, Anna M. M.; Schammel, Michel P.; Scott, Paul F.; Shimwell, Timothy W.; Titterington, David J.; Zwart, Jonathan T. L.

2011-08-01

In a previous paper (Paper I), the observational, mapping and source-extraction techniques used for the Tenth Cambridge (10C) Survey of Radio Sources were described. Here, the first results from the survey, carried out using the Arcminute Microkelvin Imager Large Array (LA) at an observing frequency of 15.7 GHz, are presented. The survey fields cover an area of ≈27 deg2 to a flux-density completeness of 1 mJy. Results for some deeper areas, covering ≈12 deg2, wholly contained within the total areas and complete to 0.5 mJy, are also presented. The completeness for both areas is estimated to be at least 93 per cent. The 10C survey is the deepest radio survey of any significant extent (≳0.2 deg2) above 1.4 GHz. The 10C source catalogue contains 1897 entries and is available online. The source catalogue has been combined with that of the Ninth Cambridge Survey to calculate the 15.7-GHz source counts. A broken power law is found to provide a good parametrization of the differential count between 0.5 mJy and 1 Jy. The measured source count has been compared with that predicted by de Zotti et al. - the model is found to display good agreement with the data at the highest flux densities. However, over the entire flux-density range of the measured count (0.5 mJy to 1 Jy), the model is found to underpredict the integrated count by ≈30 per cent. Entries from the source catalogue have been matched with those contained in the catalogues of the NRAO VLA Sky Survey and the Faint Images of the Radio Sky at Twenty-cm survey (both of which have observing frequencies of 1.4 GHz). This matching provides evidence for a shift in the typical 1.4-GHz spectral index to 15.7-GHz spectral index of the 15.7-GHz-selected source population with decreasing flux density towards sub-mJy levels - the spectra tend to become less steep. Automated methods for detecting extended sources, developed in Paper I, have been applied to the data; ≈5 per cent of the sources are found to be extended

50 CFR Figure 10 to Part 223 - Flounder TED

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Flounder TED 10 Figure 10 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig. 10 Figure 10 to Part 223—Flounder TED EC01JY91.056 [5...

Levels of 16O near 13 MeV excitation from 15N+p reactions

International Nuclear Information System (INIS)

Bray, K.H.; Frawley, A.D.; Ophel, T.R.; Barker, F.C.

1977-02-01

Angular distributions, a O 0 excitation function and Doppler-broadened γ-ray profiles for the reaction 15 N(p,α 1 γ), and angular distributions for the 15 N(p,αsub(o)) reaction, have been measured for proton energies from about 900 to 1250 keV. These data, together with analysing powers from the 15 N(p,αsub(o)) reaction with polarized protons, have been satisfactorily fitted by means of R-matrix theory, in terms of the known levels of 16 O in the 13 MeV region together with background contributions. (Author)

Blank book on energy: priority to renewable energies and energy savings

International Nuclear Information System (INIS)

Anon.

2003-01-01

The British minister of industry and trade has presented a blank book on energy. This report has in view to curb the emission of greenhouse gases by 60 % before 2050 and to double the contribution of renewable energies by 2020 with an intermediate objective of 10 % in 2010. Today this contribution reaches 3 %. New nuclear power plants are not expected to be built. This report recalls that the United-Kingdom (UK) imports half the coal it needs and states that by 2006 UK will become a net gas importing country and by 2010 a net oil importing country. The solution promoted by the report is to rely on diverse energy sources and on diverse supplying countries. (A.C.)

10 CFR 216.1 - Introduction.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Introduction. 216.1 Section 216.1 Energy DEPARTMENT OF ENERGY OIL MATERIALS ALLOCATION AND PRIORITY PERFORMANCE UNDER CONTRACTS OR ORDERS TO MAXIMIZE DOMESTIC ENERGY SUPPLIES § 216.1 Introduction. (a) This part describes and establishes the procedures to be used...

Kinetic energy of He atoms in liquid 4He-3He mixtures

International Nuclear Information System (INIS)

Senesi, R.; Andreani, C.; Fielding, A.L.; Mayers, J.; Stirling, W.G.

2003-01-01

Deep inelastic neutron scattering measurements on liquid 3 He- 4 He mixtures in the normal phase have been performed on the VESUVIO spectrometer at the ISIS pulsed neutron source at exchanged wave vectors of about q≅120.0 A -1 . The neutron Compton profiles J(y) of the mixtures were measured along the T=1.96 K isotherm for 3 He concentrations, x, ranging from 0.1 to 1.0 at saturated vapor pressures. Values of kinetic energies of 3 He and 4 He atoms as a function of x, (x), were extracted from the second moment of J(y). The present determinations of (x) confirm previous experimental findings for both isotopes and, in the case of 3 He, a substantial disagreement with theory is found. In particular (x) for the 3 He atoms is found to be independent of concentration yielding a value 3 (x=0.1)≅12 K, much lower than the value suggested by the most recent theoretical estimates of approximately 19 K

76 FR 5696 - Fluazifop-P-butyl; Pesticide Tolerances

Science.gov (United States)

2011-02-02

...: This regulation establishes tolerances for residues of fluazifop-P-butyl in or on multiple commodities... based on maternal body weight gain decrement during GD 7- 16. Incidental oral intermediate- NOAEL= 0.74....0 and 2% at 200 mg dose.) mg/kg/day based on fetal UFA = 10x weight decrement, UFH = 10x hydroureter...

Energy calibration of the EGP-10M accelerator

International Nuclear Information System (INIS)

Simakov, S.P.; Spirin, V.I.; Trufanov, A.M.; Lovchikova, G.N.

1979-01-01

Energy calibration of an electrostatic charge exchange proton accelerator in the energy range from 3 to 9 MeV is described. The calibration has been measuring the (p, n) reaction thresholds on 13 C, 63 Cu, 27 Al, 60 Ni and 50 Cr nuclei. The neutron yield is measured by a long counter located at a distance of 10-15 cm from a target. Given also are the reaction thresholds and the values of the calibration factor determined according to the yield of neutrons from (p, n) reactions for the mentioned nuclei. The analysis of the resultant calibration curve of the EGP-10 M accelerator showed that errors are practically equal to the energy instability of the beam extracted from the accelerator and constitute approximately 0.06%. Variations of the calibration factor in the 3-9 MeV range are equal to 0.38%. The success in using this method is guaranteed due to the absence of isolated resonances in the (p, n) reaction cross-section above the threshold and emission of mainly S-neutrons in the exit channel

Cross section of the {sup 11}B(n,p) {sup 11}Be reaction for 14.7-16.9 MeV neutrons

Energy Technology Data Exchange (ETDEWEB)

Stepancinc, B Z; Stanojevic, D M; Popic, V R; Aleksic, M R [Institute of nuclear sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

1966-07-15

The cross section of the {sup 11}B(n,p){sup 11}Be reaction was determined for neutron energy range from 14.7 to 16.9 MeV using the activation method. Activity measurements were done by using a coincidence spectrometer essentially consisting of two plastic scintillators. Energy dependent cross section values are presented together with the previously measured values for the energy range 14.5 - 16.9 MeV.

Small-angle p--p elastic scattering at energies between 285 and 572 MeV

International Nuclear Information System (INIS)

Aebischer, D.; Favier, B.; Greeniaus, L.G.; Hess, R.; Junod, A.; Lechanoine, C.; Nikles, J.C.; Rapin, D.; Richard-Serre, C.; Werren, D.W.

1976-01-01

Differential cross sections for elastic p--p scattering have been measured at 285, 348, 398, 414, 455, 497, 530, and 572 MeV kinetic energy. The experiment was performed at the CERN synchrocyclotron, using multiwire proportional chambers placed directly in a proton beam. Scattering was observed for theta between approx. 15 and 10 0 in the laboratory system. The ratio α/sub p/ of the real and imaginary parts of the non-spin-flip nuclear forward amplitude was derived from the interference between the Coulomb and nuclear amplitudes. The values obtained are model dependent, but in this energy range α/sub p/ is positive and decreases with energy. Qualitatively good agreement with dispersion-relation predictions is observed

Expression of MDM2 mRNA, MDM2, P53 and P16 Proteins in Urothelial Lesions in the View of the WHO 4th Edition Guidelines as A Molecular Insight towards Personalized Medicine

Directory of Open Access Journals (Sweden)

Olfat Hammam

2017-08-01

Full Text Available AIM: Here we imposed a multimarker molecular panel composed of P53, MDM2 protein & mRNA & P16 with the identification of sensitive and specific cut offs among the Egyptian urothelial carcinomas bilharzial or not emphasize the pathological and molecular classifications, pathways and prognosis as a privilege for adjuvant therapy. METHODS: Three hundred and ten urothelial lesions were pathologically evaluated and grouped as follows: 50 chronic cystitis as benign, 240 urothelial carcinomas and 20 normal bladder tissue as a control. Immunohistochemistry for MDM Protein, P16 & p53 and In Situ Hybridization for MDM2mRNA were done. RESULTS: MDM2mRNA overexpression correlated with low grade low stage non invasive tumors, while P53 > 40% & p16 40% & P16 10% from high grade, high stage invasive urothelial carcinomas (with p53 > 40, p16 40 & p16 < 10%, together with the histopathological features can distinguish in situ urothelial lesions from dysplastic and atypical lesions.

Austin Community College District's P-16 Initiative Graduates America

Science.gov (United States)

Hensley, Mary; Madsen, Gary

2010-01-01

Austin Community College (ACC) District's P-16 Initiative supports partnerships with 30 school districts--reaching traditionally underserved students and bridging the gap between high school and college--so more Texas students can reach their educational goals. The P-16 Initiative is a constellation of efforts designed to provide broad-based…

15 CFR 700.20 - Use of priority ratings.

Science.gov (United States)

2010-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE NATIONAL SECURITY INDUSTRIAL BASE REGULATIONS DEFENSE PRIORITIES AND ALLOCATIONS SYSTEM Industrial Priorities for Energy Programs § 700.20 Use of...

75 FR 34657 - Energy Efficiency and Sustainable Design Standards for New Federal Buildings

Science.gov (United States)

2010-06-18

... Efficiency and Sustainable Design Standards for New Federal Buildings AGENCY: Office of Energy Efficiency and....S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Federal Energy Management... June 11, 2010. Cathy Zoi, Assistant Secretary, Energy Efficiency and Renewable Energy. [FR Doc. 2010...

Prognostic Relevance of HPV Infection and p16 Overexpression in Squamous Cell Anal Cancer

International Nuclear Information System (INIS)

Mai, Sabine; Welzel, Grit; Ottstadt, Martine; Lohr, Frank; Severa, Sebastin; Prigge, Elena-Sophie; Wentzensen, Nicolas; Trunk, Marcus J.; Wenz, Frederik; Knebel-Doeberitz, Magnus von; Reuschenbach, Miriam

2015-01-01

Purpose: Human papillomavirus (HPV) DNA and p16 status have both been reported as prognostic factors in anal cancer, but the prognostic relevance of combined detection and particularly HPV−/p16+ and HPV+/p16− signatures is unknown. We evaluated combined HPV DNA and p16 status as a prognostic factor of treatment response in anal cancer. Methods: 106 patients treated with radiochemotherapy (RCT+5-FU/MMC) with available paraffin-embedded tumor tissue specimens were evaluated regarding local control (LC) and overall survival (OS) at 5 years. In addition to HPV DNA/p16 status, the influence of age, gender, previous surgery, initial recurrence, T stage, N status, and tumor localization was analyzed. Results: 63 patients were HPV+/p16+, 9 were HPV+/p16−, 11 were HPV−/p16+, and 23 were HPV−/p16−. In univariate analysis, LC was significantly better in patients with T1/2 stage, female gender, and HPV/p16 status. HPV+/p16+ was associated with significantly better LC (88.1%; 95% confidence interval [CI]: 78.89-97.31) compared with HPV−/p16+ (63.6%; 95% CI: 35.18-92.02; P=.021) and especially HPV−/p16− (55.8%; 95% CI: 33.46-78.14; P=.002) but not with HPV+/p16− (77.8%; 95% CI: 50.56-105.04; P=.270). OS was influenced by T stage and LC. HPV+/p16+ patients showed a trend toward better OS compared with HPV−/p16− patients (HPV+/p16+: 81.1%; 95% CI: 70.12-92.08 vs HPV−/p16−: 68.8%; 95%CI: 47.44-90.16; P=.138). On multivariate analysis, T3/4 stage and HPV/p16 status (HPV−/p16+, HPV−/p16− vs HPV+/p16+) predicted poorer LC (T3/4: 50.3% vs T1/2: 86.6%, hazard ratio [HR] 0.22; 95% CI: 0.09-0.53; P<.001; HPV+/p16+ vs HPV−/p16+: HR 4.73; 95% CI: 1.33-16.82; P=.016, and HPV+/p16+ vs HPV−/p16−: HR 6.40; 95% CI: 2.23-18.35; P<.001), whereas local relapse dramatically influenced OS. Conclusion: Our data suggest that HPV/p16 signature determines prognosis. HPV+/p16+ patients had the best prognosis, and HPV−/p16+ and HPV−/p16− patients

Prognostic Relevance of HPV Infection and p16 Overexpression in Squamous Cell Anal Cancer

Energy Technology Data Exchange (ETDEWEB)

Mai, Sabine, E-mail: sabine.mai@umm.de [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany); Welzel, Grit; Ottstadt, Martine; Lohr, Frank; Severa, Sebastin [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany); Prigge, Elena-Sophie [Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, and Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg (Germany); Wentzensen, Nicolas [Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland (United States); Trunk, Marcus J. [Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany); Wenz, Frederik [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany); Knebel-Doeberitz, Magnus von; Reuschenbach, Miriam [Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, and Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg (Germany)

2015-11-15

Purpose: Human papillomavirus (HPV) DNA and p16 status have both been reported as prognostic factors in anal cancer, but the prognostic relevance of combined detection and particularly HPV−/p16+ and HPV+/p16− signatures is unknown. We evaluated combined HPV DNA and p16 status as a prognostic factor of treatment response in anal cancer. Methods: 106 patients treated with radiochemotherapy (RCT+5-FU/MMC) with available paraffin-embedded tumor tissue specimens were evaluated regarding local control (LC) and overall survival (OS) at 5 years. In addition to HPV DNA/p16 status, the influence of age, gender, previous surgery, initial recurrence, T stage, N status, and tumor localization was analyzed. Results: 63 patients were HPV+/p16+, 9 were HPV+/p16−, 11 were HPV−/p16+, and 23 were HPV−/p16−. In univariate analysis, LC was significantly better in patients with T1/2 stage, female gender, and HPV/p16 status. HPV+/p16+ was associated with significantly better LC (88.1%; 95% confidence interval [CI]: 78.89-97.31) compared with HPV−/p16+ (63.6%; 95% CI: 35.18-92.02; P=.021) and especially HPV−/p16− (55.8%; 95% CI: 33.46-78.14; P=.002) but not with HPV+/p16− (77.8%; 95% CI: 50.56-105.04; P=.270). OS was influenced by T stage and LC. HPV+/p16+ patients showed a trend toward better OS compared with HPV−/p16− patients (HPV+/p16+: 81.1%; 95% CI: 70.12-92.08 vs HPV−/p16−: 68.8%; 95%CI: 47.44-90.16; P=.138). On multivariate analysis, T3/4 stage and HPV/p16 status (HPV−/p16+, HPV−/p16− vs HPV+/p16+) predicted poorer LC (T3/4: 50.3% vs T1/2: 86.6%, hazard ratio [HR] 0.22; 95% CI: 0.09-0.53; P<.001; HPV+/p16+ vs HPV−/p16+: HR 4.73; 95% CI: 1.33-16.82; P=.016, and HPV+/p16+ vs HPV−/p16−: HR 6.40; 95% CI: 2.23-18.35; P<.001), whereas local relapse dramatically influenced OS. Conclusion: Our data suggest that HPV/p16 signature determines prognosis. HPV+/p16+ patients had the best prognosis, and HPV−/p16+ and HPV−/p16− patients

Calculation of cross sections of discrete γ rays production in the (n,n'γ) reaction on chromium and nickel with neutron energy up to 10MeV

International Nuclear Information System (INIS)

Duchemin, B.

1975-01-01

Cross-sections for the production of de-excitation γ rays following inelastic neutron scattering have been calculated, using the statistical model, and are given for natural chromium and nickel for neutron incident energy up to 10MeV [fr

Tl{sub 10}Hg{sub 3}Cl{sub 16}: Single crystal growth, electronic structure and piezoelectric properties

Energy Technology Data Exchange (ETDEWEB)

Khyzhun, O.Y., E-mail: khyzhun@ipms.kiev.ua [Frantsevych Institute for Problems of Materials Science, National Academy of Sciences of Ukraine, 3 Krzhyzhanivsky Street, 03142 Kyiv (Ukraine); Piasecki, M. [Institute of Physics, J.Dlugosz University Częstochowa, Armii Krajowej 13/15, Częstochowa PL-42-217 (Poland); Kityk, I.V. [Electrical Engineering Department, Częstochowa University Technology, Armii Krajowej 17, PL-42-200 Częstochowa (Poland); Luzhnyi, I. [Frantsevych Institute for Problems of Materials Science, National Academy of Sciences of Ukraine, 3 Krzhyzhanivsky Street, 03142 Kyiv (Ukraine); Fedorchuk, A.O. [Department of Inorganic and Organic Chemistry, Lviv National University of Veterinary Medicine and Biotechnologies, 50 Pekarska Street, 79010 Lviv (Ukraine); Fochuk, P.M. [Yuriy Fed’kovych Chernivtsi National University, 2 Kotziubynskoho Street, 58012 Chernivtsi (Ukraine); Levkovets, S.I. [Department of Inorganic and Physical Chemistry, Lesya Ukrainka Eastern European National University, 13 Voli Avenue, 43025 Lutsk (Ukraine); Karpets, M.V. [Frantsevych Institute for Problems of Materials Science, National Academy of Sciences of Ukraine, 3 Krzhyzhanivsky Street, 03142 Kyiv (Ukraine); Parasyuk, O.V. [Department of Inorganic and Physical Chemistry, Lesya Ukrainka Eastern European National University, 13 Voli Avenue, 43025 Lutsk (Ukraine)

2016-10-15

Single crystal of the ternary halide Tl{sub 10}Hg{sub 3}Cl{sub 16} was grown using Bridgman-Stockbarger method. For the Tl{sub 10}Hg{sub 3}Cl{sub 16} crystal, we have measured X-ray photoelectron spectra for both pristine and Ar{sup +} ion-bombarded surfaces and additionally investigated photoinduced piezoelectricity. Our data indicate that the Tl{sub 10}Hg{sub 3}Cl{sub 16} single crystal surface is very sensitive with respect to Ar{sup +} ion-bombardment. In particular, Ar{sup +} ion-bombardment with energy of 3.0 keV over 5 min at an ion current density of 14 μA/cm{sup 2} causes significant changes of the elemental stoichiometry of the Tl{sub 10}Hg{sub 3}Cl{sub 16} surface resulting in an abrupt decrease of the mercury content in the top surface layers of the studied single crystal. As a result of the treatment, the mercury content becomes nil in the top surface layers. In addition, the present XPS measurements allow for concluding about very low hygroscopicity of the Tl{sub 10}Hg{sub 3}Cl{sub 16} single crystal surface. The property is extremely important for the crystal handling in optoelectronic or nano-electronic devices working at ambient conditions. The photoinduced piezoelectricity has been explored for Tl{sub 10}Hg{sub 3}Cl{sub 16} depending on nitrogen (λ=371 nm) laser power density and temperature. - Graphical abstract: As-grown single crystal boule of Tl{sub 10}Hg{sub 3}Cl{sub 16}; dependence of the effective piezoelecric coefficient d{sub 33} versus the photoinducing nitrogen laser power density, I, at different temperatures, T; and packing of the polyhedra of halide atoms around Hg atoms in the Tl{sub 10}Hg{sub 3}Cl{sub 16} structure. - Highlights: • High-quality Tl{sub 10}Hg{sub 3}Cl{sub 16} single crystal has been grown by Bridgman-Stockbarger method. • Electronic structure of Tl{sub 10}Hg{sub 3}Cl{sub 16} is studied by the XPS method. • Tl{sub 10}Hg{sub 3}Cl{sub 16} single crystal surface is sensitive with respect to Ar{sup +} ion

Significant difference in p53 and p21 protein immunoreactivity in HPV 16 positive and HPV negative breast carcinomas

International Nuclear Information System (INIS)

Hennig, E.M.; Norwegian Radium Hospital, Oslo; Kvinnsland, S.; Holm, R.; Nesland, J.M.

1999-01-01

Human papillomavirus (HPV) 16 has previously been found in 19/41 breast carcinomas (46%) in women with a history of HPV 16 positive CIN III lesions. There was no significant difference in distribution of histological subtypes, mean or median tumour diameter or number of regional lymph node metastases in the HPV positive and HPV negative breast carcinoma groups. P53, p21 and c-erbB-2 proteins were analyzed by immunohistochemistry in the HPV 16 positive and HPV negative breast carcinomas. There was a significant difference in p53 and p21 protein immunoreactivity between HPV 16 positive and HPV negative breast carcinomas (p=0.0091 and p=0.0040), with a significant less detectable p53 and p21 protein immunoreactivity in the HPV 16 positive cases. There was also a significant difference in the coexpression of p53/p21 between the HPV 16 positive and HPV 16 negative breast carcinomas (p=0.002). No significant difference in immunostaining for c-erbB-2 protein in the two groups was found (p=0.15), or for the coexpression of p53/c-erbB-2 (p=0.19). The significantly lower expression of p53 and p21 proteins in HPV 16 positive than in HPV 16 negative breast carcinomas supports the hypothesis of inactivation and degradation of wild-type p53 proteins by HPV 16 E6 and that p53 mutation is not necessary for transformation in the HPV 16 positive cases. (orig.)

76 FR 2369 - Priorities for Addressing Risks to the Reliability of the Bulk-Power System; Notice of Technical...

Science.gov (United States)

2011-01-13

... Addressing Risks to the Reliability of the Bulk- Power System; Notice of Technical Conference December 16.... The purpose of the conference is to discuss policy issues related to reliability of the Bulk-Power System, including priorities for addressing risks to reliability. The agenda for this conference will be...

HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A.

Science.gov (United States)

Lee, Sang Y; Liu, Siying; Mitchell, Ryan M; Slagle-Webb, Becky; Hong, Young-Soo; Sheehan, Jonas M; Connor, James R

2011-11-01

HFE is a protein that impacts cellular iron uptake. HFE gene variants are identified as risk factors or modifiers for multiple diseases. Using HFE stably transfected human neuroblastoma cells, we found that cells carrying the C282Y HFE variant do not differentiate when exposed to retinoic acid. Therefore, we hypothesized HFE variants would impact response to therapeutic agents. Both the human neuroblastoma and glioma cells that express the C282Y HFE variant are resistant to Temodar, geldanamycin and γ-radiation. A gene array analysis revealed that p16INK4A (p16) expression was increased in association with C282Y expression. Decreasing p16 protein by siRNA resulted in increased vulnerability to all of the therapeutic agents suggesting that p16 is responsible for the resistance. Decreasing HFE expression by siRNA resulted in a 85% decrease in p16 expression in the neuroblastoma cells but not the astrocytoma cells. These data suggest a potential direct relationship between HFE and p16 that may be cell specific or mediated by different pathways in the different cell types. In conclusion, the C282Y HFE variant impacts the vulnerability of cancer cells to current treatment strategies apparently by increasing expression of p16. Although best known as a tumor suppressor, there are multiple reports that p16 is elevated in some forms of cancer. Given the frequency of the HFE gene variants, as high as 10% of the Caucasian population, these data provide compelling evidence that the C282Y HFE variant should be part of a pharmacogenetic strategy for evaluating treatment efficacy in cancer cells. Copyright © 2011 UICC.

Phage FR38 Treatment on Sprague Dawley Rat Inferred from Blood Parameters and Organ Systems

Directory of Open Access Journals (Sweden)

DEWI SARTIKA

2012-09-01

Full Text Available The ability of phage FR38 to lysis indigenous Salmonella P38 from feces of diarrheal patient has been studied. However, effects of phage FR38 on organ system were not revealed as yet. This study was conducted to observe the effect of phage FR38 on blood chemistry, kidney functions, and liver functions. Twelve Sprague-Dawley rats were used as a model for this study that were divided into two groups; (i control and (ii treated group with phage FR38. For treated phage group, each rat was administered by 5 ml/kg bw of 1.59•107 pfu/ml of phage intragastric. The blood parameters were analysed on day 16. The results revealed that body and organs weight, erythrocyte, hematocrit, hemoglobin, leukocyte, total protein, creatinine, SGOT, and SGPT of phage treatment rats were not significantly different with the control rats on day 16 (P > 0.05. Therefore, this study showed was no effect of phage FR38 on body weight, blood chemistry, kidney and liver functions of the rat (P > 0.05.

Phage FR38 Treatment on Sprague Dawley Rat Inferred from Blood Parameters and Organ Systems

Directory of Open Access Journals (Sweden)

DEWI SARTIKA

2012-09-01

Full Text Available The ability of phage FR38 to lysis indigenous Salmonella P38 from feces of diarrheal patient has been studied. However, effects of phage FR38 on organ system were not revealed as yet. This study was conducted to observe the effect of phage FR38 on blood chemistry, kidney functions, and liver functions. Twelve Sprague-Dawley rats were used as a model for this study that were divided into two groups; (i control and (ii treated group with phage FR38. For treated phage group, each rat was administered by 5 ml/kg bw of 1.59-107 pfu/ml of phage intragastric. The blood parameters were analysed on day 16. The results revealed that body and organs weight, erythrocyte, hematocrit, hemoglobin, leukocyte, total protein, creatinine, SGOT, and SGPT of phage treatment rats were not significantly different with the control rats on day 16 (P > 0.05. Therefore, this study showed was no effect of phage FR38 on body weight, blood chemistry, kidney and liver functions of the rat (P > 0.05.

Direct reactions induced by 16O on 208Pb at high incident energy

International Nuclear Information System (INIS)

Mermaz, M.C.

1978-01-01

Direct reactions induced by 16 O mainly on 208 Pb at 20 MeV/nucleon are reviewed. The quasi-elastic transfer reaction, such as one-proton and one-neutron transfer respectively leading to 209 Bi and 209 Pb single-particle-states, is first discussed, the fragmentation of 16 O projectile on heavy targets is then envisaged. The one-nucleon transfer can be described within the framework of one-step processes using the DWBA formalism to calculate the cross sections. At high incident energy (312.6 MeV), transfer reactions involving nucleons from the deeper 1p 3/2 orbit of 16 O are kinematically favoured and well observed. At 20 MeV/A and above, a large part of the reaction cross sections seems to be due to the fragmentation of the projectile; more especially, an abrasion-ablation model have to be used in order to explain the general trend of the data (energy spectra and angular distribution)

Bone induction by biomimetic PLGA copolymer loaded with a novel synthetic RADA16-P24 peptide in vivo

International Nuclear Information System (INIS)

Pan, Haitao; Hao, Shaofei; Zheng, Qixin; Li, Jingfeng; Zheng, Jin; Hu, Zhilei; Yang, Shuhua; Guo, Xiaodong; Yang, Qin

2013-01-01

Bone morphogenetic protein-2 (BMP-2) is a key bone morphogenetic protein, and poly(lactic-co-glycolic acid) (PLGA) has been widely used as scaffold for clinical use to carry treatment protein. In the previous studies, we have synthesized BMP-2-related peptide (P24) and found its capacity of inducing bone regeneration. In this research, we have synthesized a new amphiphilic peptide Ac-RADA RADA RADA RADA S[PO4]KIPKASSVPTELSAISTLYLDDD-CONH2 (RADA16-P24) with an assembly peptide RADA16-Ion the P24 item of BMP2 to form divalent ion-induced gelatin. Two methods of physisorption and chemical cross-linking were used to bind RADA16-P24 onto the surface of the copolymer PLGA to synthesize RADA16-P24–PLGA, and its capacity of attaching bone marrow stromal cells (BMSCs) was evaluated in vitro and inducing ectopic bone formation was examined in vivo. In vitro our results demonstrated that RADA16-P24–PLGA copolymer prepared by physisorbing or prepared by chemical cross-linking had a peptide binding rate of (2.0180 ± 0.5296)% or (10.0820 ± 0.8405)% respectively (P < 0.05). In addition the BMSCs proliferated vigorously in the RADA16-P24–PLGA biomaterials. Significantly the percentage of BMSCs attached to RADA16-P24–PLGA composite prepared by chemical cross-linking and physisorbing were (71.4 ± 7.5) % or (46.7 ± 5.8) % (P < 0.05). The in vivo study showed that RADA16-P24–PLGA chemical cross-linking could better induce ectopic bone formation compared with RADA16-P24–PLGA physisorbing and PLGA. It is concluded that the PLGA copolymer is a good RADA16-P24 carrier. This novel RADA16-P24–PLGA composite has strong osteogenic capability. - Highlights: • We have synthesized a new RADA16-P24 amphiphilic peptide. • It is an assembly peptide RADA16-Ion the P24 to form divalent ion-induced gelatin. • RADA16-P24/PLGA could better induce etopia osteogenesis compared with PLGA. • RADA16-P24–PLGA has strong osteogenic capability

Bone induction by biomimetic PLGA copolymer loaded with a novel synthetic RADA16-P24 peptide in vivo

Energy Technology Data Exchange (ETDEWEB)

Pan, Haitao; Hao, Shaofei [Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 (China); Zheng, Qixin, E-mail: zheng-qx@163.com [Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 (China); Li, Jingfeng [Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 (China); Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China); Zheng, Jin; Hu, Zhilei; Yang, Shuhua; Guo, Xiaodong [Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 (China); Yang, Qin [Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074 (China)

2013-08-01

Bone morphogenetic protein-2 (BMP-2) is a key bone morphogenetic protein, and poly(lactic-co-glycolic acid) (PLGA) has been widely used as scaffold for clinical use to carry treatment protein. In the previous studies, we have synthesized BMP-2-related peptide (P24) and found its capacity of inducing bone regeneration. In this research, we have synthesized a new amphiphilic peptide Ac-RADA RADA RADA RADA S[PO4]KIPKASSVPTELSAISTLYLDDD-CONH2 (RADA16-P24) with an assembly peptide RADA16-Ion the P24 item of BMP2 to form divalent ion-induced gelatin. Two methods of physisorption and chemical cross-linking were used to bind RADA16-P24 onto the surface of the copolymer PLGA to synthesize RADA16-P24–PLGA, and its capacity of attaching bone marrow stromal cells (BMSCs) was evaluated in vitro and inducing ectopic bone formation was examined in vivo. In vitro our results demonstrated that RADA16-P24–PLGA copolymer prepared by physisorbing or prepared by chemical cross-linking had a peptide binding rate of (2.0180 ± 0.5296)% or (10.0820 ± 0.8405)% respectively (P < 0.05). In addition the BMSCs proliferated vigorously in the RADA16-P24–PLGA biomaterials. Significantly the percentage of BMSCs attached to RADA16-P24–PLGA composite prepared by chemical cross-linking and physisorbing were (71.4 ± 7.5) % or (46.7 ± 5.8) % (P < 0.05). The in vivo study showed that RADA16-P24–PLGA chemical cross-linking could better induce ectopic bone formation compared with RADA16-P24–PLGA physisorbing and PLGA. It is concluded that the PLGA copolymer is a good RADA16-P24 carrier. This novel RADA16-P24–PLGA composite has strong osteogenic capability. - Highlights: • We have synthesized a new RADA16-P24 amphiphilic peptide. • It is an assembly peptide RADA16-Ion the P24 to form divalent ion-induced gelatin. • RADA16-P24/PLGA could better induce etopia osteogenesis compared with PLGA. • RADA16-P24–PLGA has strong osteogenic capability.

File list: Oth.ALL.10.daf-16.AllCell [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.ALL.10.daf-16.AllCell ce10 TFs and others daf-16 All cell types SRX005634,SRX00...5631 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/Oth.ALL.10.daf-16.AllCell.bed ...

Collisional energy transfer in Na(4p--3d)--He,H2 collisions

International Nuclear Information System (INIS)

Kleiber, P.D.; Wong, T.H.; Bililign, S.

1993-01-01

We have investigated the direct collisional energy transfer process Na*(4p)+M→Na*(3d)+M, where M=He,H 2 under gas cell conditions. We have measured the temporal profiles of the Na(3d--3p) sensitized fluorescence as a function of quenching gas pressure and fit the profiles to a two-state rate equation model to obtain the quenching rate coefficients from the Na*(4p) state. The total energy transfer rate coefficient out of the 4p state for He is small [(0.5±0.2)x10 -10 cm 3 /s]. The total quenching rate coefficient out of the 4p state is much larger for H 2 [(3.9±0.5)x10 -10 cm 3 /s]. Evidence suggests that the energy transfer rate coefficient for the 4p--3d process is ∼2.0x10 -10 cm 3 /s with the remainder of the 4p quenching being predominantly reactive. We also compare the far-red wing absorption line shapes for the NaHe and NaH 2 systems

High energy P implants in silicon

International Nuclear Information System (INIS)

Raineri, V.; Cacciato, A.; Benyaich, F.; Priolo, F.; Rimini, E.; Galvagno, G.; Capizzi, S.

1992-01-01

Phosphorus ions in the energy range 0.25-1 MeV and in the dose range 2x10 13 -1x10 15 P/cm 2 were implanted into (100) Si single crystal at different tilt angles. In particular channeling and random conditions were investigated. For comparison some implants were performed on samples with a 2 μm thick surface amorphous layer. Chemical concentration P profiles were obtained by secondary ion mass spectrometry. Carrier concentration and mobility profile measurements were carried out by sheet resistance and Hall measurements on implanted van der Pauw patterns. Carrier concentration profiles were also obtained by spreading resistance (SR) measurements. The damage in the as-implanted samples was determined by backscattering and channeling spectrometry (RBS) as a function of the dose and implantation energy. Comparison of random implants in crystal with implants in amorphous layers shows that in the first case it is impossible to completely avoid the channeling tail. In the implants performed under channeling conditions at low doses the P profiles are flat over more than 2 μm thick layers. Furthermore, by increasing the implanted dose, the shape of the profiles dramatically changes due to the dechanneling caused by the crystal disorder. The data are discussed and compared with Monte Carlo simulations using the MARLOWE code. A simple description of the electronic energy loss provides an excellent agreement between the calculated and experimental profiles. (orig.)

p16 (INK4a) has clinicopathological and prognostic impact on oropharynx and larynx squamous cell carcinoma

Energy Technology Data Exchange (ETDEWEB)

Silva, S.D. [Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia, Hospital A.C. Camargo, São Paulo, SP (Brazil); Department of Oncology, Lady Davis Institute for Medical Research and Segal Cancer Centre, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec (Canada); Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Quebec (Canada); Nonogaki, S. [Departamento de Anatomia Patológica, Hospital A.C. Camargo, São Paulo, SP (Brazil); Soares, F.A. [Departamento de Anatomia Patológica, Hospital A.C. Camargo, São Paulo, SP (Brazil); Departamento de Estomatologia, Faculdade de Odontologia, Universidade de São Paulo, São Paulo, SP (Brazil); Kowalski, L.P. [Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia, Hospital A.C. Camargo, São Paulo, SP (Brazil)

2012-09-07

CDKN2A encodes proteins such as p16 (INK4a), which negatively regulate the cell-cycle. Molecular genetic studies have revealed that deletions in CDKN2A occur frequently in cancer. Although p16 (INK4a) may be involved in tumor progression, the clinical impact and prognostic implications in head and neck squamous cell carcinoma (HNSCC) are controversial. The objective of this study was to evaluate the frequency of the immunohistochemical expression of p16 (INK4a) in 40 oropharynx and 35 larynx from HNSCC patients treated in a single institution and followed-up at least for 10 years in order to explore potential associations with clinicopathological outcomes and prognostic implications. Forty cases (53.3%) were positive for p16 (INK4a) and this expression was more intense in non-smoking patients (P = 0.050), whose tumors showed negative vascular embolization (P = 0.018), negative lymphatic permeation (P = 0.002), and clear surgical margins (P = 0.050). Importantly, on the basis of negative p16 (INK4a) expression, it was possible to predict a probability of lower survival (P = 0.055) as well as tumors presenting lymph node metastasis (P = 0.050) and capsular rupture (P = 0.0010). Furthermore, increased risk of recurrence was observed in tumors presenting capsular rupture (P = 0.0083). Taken together, the alteration in p16 (INK4a) appears to be a common event in patients with oropharynx and larynx squamous cell carcinoma and the negative expression of this protein correlated with poor prognosis.

p16 (INK4a) has clinicopathological and prognostic impact on oropharynx and larynx squamous cell carcinoma

International Nuclear Information System (INIS)

Silva, S.D.; Nonogaki, S.; Soares, F.A.; Kowalski, L.P.

2012-01-01

CDKN2A encodes proteins such as p16 (INK4a), which negatively regulate the cell-cycle. Molecular genetic studies have revealed that deletions in CDKN2A occur frequently in cancer. Although p16 (INK4a) may be involved in tumor progression, the clinical impact and prognostic implications in head and neck squamous cell carcinoma (HNSCC) are controversial. The objective of this study was to evaluate the frequency of the immunohistochemical expression of p16 (INK4a) in 40 oropharynx and 35 larynx from HNSCC patients treated in a single institution and followed-up at least for 10 years in order to explore potential associations with clinicopathological outcomes and prognostic implications. Forty cases (53.3%) were positive for p16 (INK4a) and this expression was more intense in non-smoking patients (P = 0.050), whose tumors showed negative vascular embolization (P = 0.018), negative lymphatic permeation (P = 0.002), and clear surgical margins (P = 0.050). Importantly, on the basis of negative p16 (INK4a) expression, it was possible to predict a probability of lower survival (P = 0.055) as well as tumors presenting lymph node metastasis (P = 0.050) and capsular rupture (P = 0.0010). Furthermore, increased risk of recurrence was observed in tumors presenting capsular rupture (P = 0.0083). Taken together, the alteration in p16 (INK4a) appears to be a common event in patients with oropharynx and larynx squamous cell carcinoma and the negative expression of this protein correlated with poor prognosis

Aqueous fraction from Cuscuta japonica seed suppresses melanin synthesis through inhibition of the p38 mitogen-activated protein kinase signaling pathway in B16F10 cells.

Science.gov (United States)

Jang, Ji Yeon; Kim, Ha Neui; Kim, Yu Ri; Choi, Yung Hyun; Kim, Byung Woo; Shin, Hwa Kyoung; Choi, Byung Tae

2012-05-07

Semen cuscutae has been used traditionally to treat pimples and alleviate freckles and melasma in Korea. The present study aimed to investigate the inhibitory effect of Cuscuta japonica Choisy seeds on alpha-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis. The aqueous fraction from Semen cuscutae (AFSC) was used to determine anti-melanogenic effects by examination of cellular melanin contents, tyrosinase activity assay, cAMP assay and Western blot analysis for melanin synthesis-related signaling proteins in B16F10 mouse melanoma cells. AFSC markedly inhibited α-MSH-induced melanin synthesis and tyrosinase activity, and also decreased α-MSH-induced expression of microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins (TRPs). Moreover, AFSC significantly decreased the level of phosphorylated p38 mitogen-activated protein kinase (MAPK) signaling through the down-regulation of α-MSH-induced cAMP. Furthermore, we confirmed that the specific inhibitor of p38 MAPK (SB203580)-mediated suppressed melanin synthesis and tyrosinase activity was further attenuated by AFSC. AFSC also further decreased SB203580-mediated suppression of MITF and TRP expression. These results indicate that AFSC inhibits p38 MAPK phosphorylation with suppressed cAMP levels and subsequently down-regulate MITF and TRP expression, which results in a marked reduction of melanin synthesis and tyrosinase activity in α-MSH-stimulated B16F10 cells. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

75 FR 3902 - Notice of Public Hearings on the Draft Tank Closure and Waste Management Environmental Impact...

Science.gov (United States)

2010-01-25

... Tank Closure and Waste Management Environmental Impact Statement for the Hanford Site, Richland... Environmental Management. [FR Doc. 2010-1306 Filed 1-22-10; 8:45 am] BILLING CODE 6450-01-P ... DEPARTMENT OF ENERGY Notice of Public Hearings on the Draft Tank Closure and Waste Management...

77 FR 61031 - Investigations Regarding Eligibility To Apply for Worker Adjustment Assistance

Science.gov (United States)

2012-10-05

... Direct Energy, Back Office Tulsa, OK 09/17/12 09/12/12 Operations (Workers). 81972 IMS Health.......... 09/18/12 09/11/12 One-Stop). 81976 Custom Food (State/One- Shreveport, LA........ 09/18/12 09/17/12... Systems-Fast (State/One- Stop). [FR Doc. 2012-24556 Filed 10-4-12; 8:45 am] BILLING CODE 4510-FN-P ...

Electrical properties of n-type and p-type InP grown by the synthesis, solute diffusion technique

International Nuclear Information System (INIS)

Siegel, W.; Kuehnel, G.; Koi, H.; Gerlach, W.

1986-01-01

Undoped n-InP and Zn-doped p-InP are grown by the SSD method. Hall measurements on wafers cut from the polycrystalline n-InP ingots give values between 10 15 and 10 16 cm -3 for the carrier concentration averaged over the crystallites of the wafer. From the electron mobilities measured at 77 K on single crystalline samples (maximally 5.0 x 10 4 cm 2 /Vs) it can be concluded on the high purity and perfection of this material. Zn doping yields p-InP with p = (3 to 4) x 10 16 cm -3 and μ = (113 to 140) cm 2 /Vs at room temperature. The hole mobilities at 77 K (1700 to 2160 cm 2 /Vs) are the highest ones reported for InP up to now. By fitting of the p(T) curves between 30 and 500 K concentrations and activation energies for the shallow acceptor Zn and for a medium deep acceptor present beside Zn are determined. (author)

Low temperature irradiation of iron, zirconium and copper by 10 to 16 MeV protons

Energy Technology Data Exchange (ETDEWEB)

Omar, A M

1978-01-01

A theoretical analysis of scattering and radiation damage parameters is carried out for 14 MeV neutrons and 10-17 MeV protons on Fe, Ni, Cu, Zr, Nb, and Au. Damage energies are computed for the interactions using both elastic and non-elastic data. The results show that proton encounters deposit a greater damage energy than 14 MeV neutrons. To examine the theoretical results, electrical resistivity measurements are undertaken for Fe, Zr and Cu irradiated at 12 to 17.5K with 10 to 16 MeV protons. Post-irradiation annealing is carried out in situ using a closed-cycle helium-cooled cryostat. Values of the resistivity damage rate are compared with values estimated from the theoretical damage-energy results. Also, the observed stage I recovery is analysed in terms of the corresponding recovery reported for electron and fast-neutron irradiations. The relation between the 16 MeV proton data and published data estimated from a fusion reactor spectrum is discussed. It is also shown that protons create a damage structure similar to a superposition of the damage structures generated by electrons and fast neutrons. The sample state of imperfection is shown to influence the induced damage state in proton irradiation.

Evaluation of P16 expression in canine appendicular osteosarcoma.

Science.gov (United States)

Murphy, B G; Mok, M Y; York, D; Rebhun, R; Woolard, K D; Hillman, C; Dickinson, P; Skorupski, K

2017-06-20

Osteosarcoma (OSA) is a common malignant bone tumor of large breed dogs that occurs at predictable anatomic sites. At the time of initial diagnosis, most affected dogs have occult pulmonary metastases. Even with aggressive surgical treatment combined with chemotherapy, the majority of dogs diagnosed with OSA live less than 1 year from the time of diagnosis. The ability to identify canine OSA cases most responsive to treatment is needed. In humans, OSA is also an aggressive tumor that is histologically and molecularly similar to canine OSA. The expression of the tumor suppressor gene product P16 by human OSA tissue has been linked to a favorable response to chemotherapy. We identified an antibody that binds canine P16 and developed a canine OSA tissue microarray in order to test the hypothesis that P16 expression by canine OSA tissue is predictive of clinical outcome following amputation and chemotherapy. Although statistical significance was not reached, a trend was identified between the lack of canine OSA P16 expression and a shorter disease free interval. The identification of a molecular marker for canine OSA is an important goal and the results reported here justify a larger study.

Priorities of statutory claimants

International Nuclear Information System (INIS)

Pawluck, B.K.; Prowse, J.T.

1996-01-01

The statutory rights that unpaid creditors have when an oil or gas operator is placed in bankruptcy, were evaluated. Those statutory rights may give priority to their claims against the operator. Fifteen topics dealing with statutory priorities were examined, focusing on the change in priorities which would occur if the insolvent operator were placed in bankruptcy. The topics were: (1) Summary of statutory federal and provincial priorities, (2) Revenue Canada - source deductions/deemed trust, (3) Revenue Canada - source deductions/enhanced requirement to pay, (4) Revenue Canada - goods and service tax (GST)/deemed trust, (5) Revenue Canada - GST/enhanced requirement to pay, (6) Federal income taxes, (7) Validity of provincially legislated priority provisions in bankruptcy, (8) Provincially authorized municipal taxes - real property, (9) Provincial workers' compensation board, (10) Provincially legislated wages, overtime pay and holiday pay, (11) Provincially legislated severance/termination pay, (12) Provincially legislated successor employer obligations, (13) Provincially legislated private employment pension plans, (14) Provincial health care insurance premiums, and (15) Provincial freehold mineral rights tax

Aging and chronic alcohol consumption are determinants of p16 gene expression, genomic DNA methylation and p16 promoter methylation in the mouse colon

Science.gov (United States)

Elder age and chronic alcohol consumption are important risk factors for the development of colon cancer. Each factor can alter genomic and gene-specific DNA methylation. This study examined the effects of aging and chronic alcohol consumption on genomic and p16-specific methylation, and p16 express...

16% renewable energy in 2020. When invite for tenders?; 16% hernieuwbare energie in 2020. Wanneer aanbesteden?

Energy Technology Data Exchange (ETDEWEB)

Hekkenberg, M.; Lensink, S. [ECN Beleidsstudies, Petten (Netherlands)

2013-01-15

The Dutch government has set a target of 16% renewable energy to be realized in 2020. This goal is feasible, when a sufficiently supportive policy framework is established. This study examines the turnaround of projects and the potential growth path of different technologies that can be used to achieve the goal. The study works step by step towards an answer to the key question: What is the ultimate time of procurement by the government, or of establishing a binding legal framework, to ensure the required capacity of key renewable energy technologies in 2020, taking into account the time for completion of the project completion and any growth limitations [Dutch] Het huidige regeerakkoord stelt een doel van 16% hernieuwbare energie in 2020. Dit doel lijkt begin 2013 binnen bereik te liggen, wanneer een voldoende ondersteunend beleidskader tijdig wordt vastgesteld. Deze studie onderzoekt de doorlooptijd van projecten en het mogelijke ingroeipad van verschillende technologieën die ingezet kunnen worden om het doel te bereiken. De studie werkt stapsgewijs toe naar een antwoord op de kernvraag: Wat is het uiterste moment van aanbesteding door de overheid, of van vaststelling van een bindend wettelijk kader, om de benodigde capaciteit van de belangrijkste hernieuwbare-energietechnologieën in 2020 zeker te stellen, rekening houdend met projectdoorlooptijd en eventuele ingroeibeperkingen.

Low energy pion-16O scattering

International Nuclear Information System (INIS)

Wafelbakker, C.K.

1981-01-01

In spite of some outward appearances, the modern microscopic theories of the pion-nucleus (πA) interaction are not fundamentally very different from each other. They can all be derived from the same source, multiple-scattering theory. They all treat the first-order optical potential in a comparatively detailed way and in all of them it is necessary to incorporate higher-order effects in general and pion-annihilation in particular phenomenologically. Basically the same physical features can be embodied in all of them. The presentation of the theoretical scheme underlying the present thesis is designed to stress this conceptual unity of current πA theory. In this thesis the methods developed by De Kam to incorporate Pauli- and binding-corrections to the impulse-approximation first-order optical potential for 4 He are extended to a more complicated nucleus, 16 O, for the first time. In concreto two situations are considered: π- 16 O scattering at energies below nucleon-knockout threshold (13.5 MeV) - 7 and 12 MeV - and at energies 40 and 49.7 MeV, above nucleon-knockout threshold but still well within the low-energy region. (Auth.)

76 FR 396 - Product Change-Priority Mail-Non-Published Rates

Science.gov (United States)

2011-01-04

... POSTAL SERVICE Product Change--Priority Mail--Non-Published Rates AGENCY: Postal Service TM . ACTION: Notice. SUMMARY: Postal Service notice of filing of a request with the Postal Regulatory... States Postal Service Concerning Priority Mail--Non-Published Rates and Notice of Filing Materials Under...

Hinokitiol, a tropolone derivative, inhibits mouse melanoma (B16-F10) cell migration and in vivo tumor formation.

Science.gov (United States)

Huang, Chien-Hsun; Lu, Shing-Hwa; Chang, Chao-Chien; Thomas, Philip Aloysius; Jayakumar, Thanasekaran; Sheu, Joen-Rong

2015-01-05

Invasion and metastasis are the major causes of treatment failure in patients with cancer. Hinokitiol, a natural bioactive compound found in Chamacyparis taiwanensis, has been used in hair tonics, cosmetics, and food as an antimicrobial agent. In this study, we investigated the effects and possible mechanisms of action of hinokitiol on migration by the metastatic melanoma cell line, B16-F10, in which matrix metalloproteinase-1 (MMP-1) is found to be highly- expressed. Treatment with hinokitiol revealed a concentration-dependent inhibition of migration of B16-F10 melanoma cells. Hinokitiol appeared to achieve this effect by reducing the expression of MMP-1 and by suppressing the phosphorylation of mitogen- activated protein kinase (MAPK) signaling molecules such as extracellular signal-regulated kinase (ERK) 1/2, p38 MAPK and c-Jun N-terminal kinases (JNK). On the other hand, hinokitiol treatment reversed IκB-α degradation and inhibited the phosphorylation of p65 nuclear factor kappa B (NF-κB) and cJun in B16-F10 cells. In addition, hinokitiol suppressed the translocation of p65 NF-κB from the cytosol to the nucleus, suggesting reduced NF-κB activation. Consistent with these in vitro findings, our in vivo study demonstrated that hinokitiol treatment significantly reduced the total number of mouse lung metastatic nodules and improved histological alterations in B16-F10 injected C57BL/6 mice. These findings suggest that treatment of B16-F10 cells with hinokitiol significantly inhibits metastasis, possibly by blocking MMP-1 activation, MAPK signaling pathways and inhibition of the transcription factors, NF-κB and c-Jun, involved in cancer cell migration. These results may accelerate the development of novel therapeutic agents for the treatment of malignant cancers. Copyright © 2014 Elsevier B.V. All rights reserved.

ABNT NBR ISO 26000 priorities to integrate the social responsibilities in peaceful use of nuclear energy

Energy Technology Data Exchange (ETDEWEB)

Biazini Filho, Francisco L.; Sordi, Gian-Maria, E-mail: gian@atomo.com.br, E-mail: Francisco.biazini@usp.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2013-07-01

The aim of this paper is to indicate the priorities in the themes and issues to integrate the social responsibilities (SR) in of the peaceful use of nuclear energy. The ABNT NBR ISO 26000 - Guidance on Social Responsibility{sub (1)}. Social responsibility should be an integral part of core organizational strategy, with assigned responsibilities and accountability at all appropriate levels of the organization. It should be reflected in decision making and considered in implementing activities. The process suggested is: 1 - determining relevance; 2 - determining significance and 3 - establishing priorities for addressing issues. The relevancies of each issue are established for us, in this paper, from the activities of the peaceful use of nuclear energy. For each relevant issue the priority are established and are: Core subject : The environment 6.5: Issue 1 : Prevention of pollution 6.5.3: Offers guidances to recognized authority sources on how to measure, assess, prevent or control the most common forms of pollution, including emissions to air, discharge waters, toxic products, waste management, biological agents, odors, visual pollution, among others. Core subject : The environment 6.5: Issue 2 : Sustainable resource use 6.5.4: Presents a series of actions aimed at the more smart use of resources, including energy efficiency, conservation, access and use of water, and extracting the most efficiency in the use of materials, renewable or not, reusing or recycling these resources whenever possible. Core subject : Community involvement and development 6.8: Issue 6 : Health 6.8.8: The organization must appreciate to eliminate the negative impacts of their activities on people's health, contributing as possible pair increase access to medicines and sanitation, as well as raise awareness about the disease as much as healthy lifestyles. In the next jobs we should consider the following to determine whether an action to address these 3 issues. (author)

ABNT NBR ISO 26000 priorities to integrate the social responsibilities in peaceful use of nuclear energy

International Nuclear Information System (INIS)

Biazini Filho, Francisco L.; Sordi, Gian-Maria

2013-01-01

The aim of this paper is to indicate the priorities in the themes and issues to integrate the social responsibilities (SR) in of the peaceful use of nuclear energy. The ABNT NBR ISO 26000 - Guidance on Social Responsibility (1) . Social responsibility should be an integral part of core organizational strategy, with assigned responsibilities and accountability at all appropriate levels of the organization. It should be reflected in decision making and considered in implementing activities. The process suggested is: 1 - determining relevance; 2 - determining significance and 3 - establishing priorities for addressing issues. The relevancies of each issue are established for us, in this paper, from the activities of the peaceful use of nuclear energy. For each relevant issue the priority are established and are: Core subject : The environment 6.5: Issue 1 : Prevention of pollution 6.5.3: Offers guidances to recognized authority sources on how to measure, assess, prevent or control the most common forms of pollution, including emissions to air, discharge waters, toxic products, waste management, biological agents, odors, visual pollution, among others. Core subject : The environment 6.5: Issue 2 : Sustainable resource use 6.5.4: Presents a series of actions aimed at the more smart use of resources, including energy efficiency, conservation, access and use of water, and extracting the most efficiency in the use of materials, renewable or not, reusing or recycling these resources whenever possible. Core subject : Community involvement and development 6.8: Issue 6 : Health 6.8.8: The organization must appreciate to eliminate the negative impacts of their activities on people's health, contributing as possible pair increase access to medicines and sanitation, as well as raise awareness about the disease as much as healthy lifestyles. In the next jobs we should consider the following to determine whether an action to address these 3 issues. (author)

78 FR 28841 - Quartzsite Solar Energy Project Record of Decision (DOE/EIS-0440)

Science.gov (United States)

2013-05-16

... DEPARTMENT OF ENERGY Western Area Power Administration Quartzsite Solar Energy Project Record of...), received a request from Quartzsite Solar Energy, LLC (QSE) to interconnect its proposed Quartzsite Solar... (PRMPA) for Quartzsite Solar Energy Project was published in the Federal Register (77 FR 75632). After...

Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders.

Directory of Open Access Journals (Sweden)

Maria Tropeano

Full Text Available Copy number variants (CNVs at chromosome 16p13.11 have been associated with a range of neurodevelopmental disorders including autism, ADHD, intellectual disability and schizophrenia. Significant sex differences in prevalence, course and severity have been described for a number of these conditions but the biological and environmental factors underlying such sex-specific features remain unclear. We tested the burden and the possible sex-biased effect of CNVs at 16p13.11 in a sample of 10,397 individuals with a range of neurodevelopmental conditions, clinically referred for array comparative genomic hybridisation (aCGH; cases were compared with 11,277 controls. In order to identify candidate phenotype-associated genes, we performed an interval-based analysis and investigated the presence of ohnologs at 16p13.11; finally, we searched the DECIPHER database for previously identified 16p13.11 copy number variants. In the clinical referral series, we identified 46 cases with CNVs of variable size at 16p13.11, including 28 duplications and 18 deletions. Patients were referred for various phenotypes, including developmental delay, autism, speech delay, learning difficulties, behavioural problems, epilepsy, microcephaly and physical dysmorphisms. CNVs at 16p13.11 were also present in 17 controls. Association analysis revealed an excess of CNVs in cases compared with controls (OR = 2.59; p = 0.0005, and a sex-biased effect, with a significant enrichment of CNVs only in the male subgroup of cases (OR = 5.62; p = 0.0002, but not in females (OR = 1.19, p = 0.673. The same pattern of results was also observed in the DECIPHER sample. Interval-based analysis showed a significant enrichment of case CNVs containing interval II (OR = 2.59; p = 0.0005, located in the 0.83 Mb genomic region between 15.49-16.32 Mb, and encompassing the four ohnologs NDE1, MYH11, ABCC1 and ABCC6. Our data confirm that duplications and deletions at 16p13

The 2H(e, e' p)n reaction at large energy transfers

NARCIS (Netherlands)

Willering, Hendrik Willem

2003-01-01

At the ELSA accelerator facillity in Bonn, Germany, we have measured the deutron "breakup" reaction 2H(e,e' p)n at four-momentum transfers around Q2 = -0 .20(GeV/c)2 with an electron beam energy of E0 = 1.6 GeV. The cross section has been determined for energy transfers extending from the

Binding energy and single-particle energies in the 16O Region

International Nuclear Information System (INIS)

Fiase, J.O.; Sharma, L.K.

2004-01-01

In this paper we present the binding energy of 16 O together with single-particle energies in the oxygen region by folding together a Hamiltonian in the rest-frame of the nucleus with two-body correlation functions based on the Nijmegen potential. We have found that the binding energies are very sensitive to the core radius rc and that the effects of tensor correlations are non-negligible.Our calculated binding energy, E B = - 127.8 MeV with r c = 0.241 fm compares well with the experimental binding energy, E B = - 127.6 MeV

Reconstructing an f(R) model from holographic dark energy: using the observational evidence

International Nuclear Information System (INIS)

Saaidi, Kh; Aghamohammadi, A

2012-01-01

We investigate the correspondence relation between f(R) gravity and an interacting holographic dark energy (HDE). By obtaining the conditions needed for some observational evidence such as positive acceleration expansion of the Universe, crossing the phantom divide line and validity of the thermodynamics second law in an interacting HDE model and corresponding it with the f(R) model of gravity, we find a viable f(R) model that can explain the present Universe. We also obtain the explicit evolutionary forms of the corresponding scalar field, potential and scale factor of the Universe. (paper)

Priority for import capacity. The fear of the European Union for a free European energy market

International Nuclear Information System (INIS)

Roggen, M.

2002-01-01

Brussels (the seat of the European Union in Belgium) is worried about the performance of the liberalized European energy market. The natural gas and electricity networks are suffering from chronic congestion. Some areas are largely or even entirely cut off from the European energy infrastructure. Those problems must be addressed to realize the internal market. A package of reforms has been put forward by the European Commission the end of 2001 and 12 priority projects are identified and briefly discussed in this article [nl

p16INK4A, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: Correlation with outcomes following chemo-radiotherapy

International Nuclear Information System (INIS)

Gilbert, Duncan C; Williams, Anthony; Allan, Kimberley; Stokoe, Joanna; Jackson, Tim; Linsdall, Suzanne; Bailey, Charles MH; Summers, Jeff

2013-01-01

Background and Purpose: Squamous cell carcinomas of the anal canal are associated with infection with Human Papilloma Viruses (HPVs). Chemo-radiotherapy (CRT) gives 70% 3-year relapse-free survival. Improved predictive markers and therapeutic options are required. Methods: Tumours from 153 patients treated with radical chemo-radiotherapy (50.4 Gy in 28 with concurrent Mitomycin and 5-Fluorouracil between 2004 and 2009) were retrieved and immunohistochemistry performed for p16 INK4A , p53 and EGFR and correlated with outcome. Primary and relapsed samples were analysed for mutations in KRAS. Results: 137/153 (89.5%) stained moderately or strongly for p16 INK4A . p16 INK4A correlated strongly with outcome. 37/137 patients demonstrating moderate/strong p16 INK4A expression relapsed (27.0%), as opposed to 10/16 (62.5%) with absent/weak staining (log rank test p INK4A negative tumours were more frequent in men. p16 INK4A negative patients had significantly worse overall survival (p INK4A is strongly associated with relapse in SCC of the anus and identifies patients with very poor rates of relapse-free and overall survival. Primary and recurrent anal cancer expresses wild type KRAS, unaffected by treatment, supporting trials targeting EGFR in poor risk/recurrent anal cancer

Transit-Based Emergency Evacuation with Transit Signal Priority in Sudden-Onset Disaster

Directory of Open Access Journals (Sweden)

Ciyun Lin

2016-01-01

Full Text Available This study presents methods of transit signal priority without transit-only lanes for a transit-based emergency evacuation in a sudden-onset disaster. Arterial priority signal coordination is optimized when a traffic signal control system provides priority signals for transit vehicles along an evacuation route. Transit signal priority is determined by “transit vehicle arrival time estimation,” “queuing vehicle dissipation time estimation,” “traffic signal status estimation,” “transit signal optimization,” and “arterial traffic signal coordination for transit vehicle in evacuation route.” It takes advantage of the large capacities of transit vehicles, reduces the evacuation time, and evacuates as many evacuees as possible. The proposed methods were tested on a simulation platform with Paramics V6.0. To evaluate and compare the performance of transit signal priority, three scenarios were simulated in the simulator. The results indicate that the methods of this study can reduce the travel times of transit vehicles along an evacuation route by 13% and 10%, improve the standard deviation of travel time by 16% and 46%, and decrease the average person delay at a signalized intersection by 22% and 17% when the traffic flow saturation along an evacuation route is 0.81.0, respectively.

HySafe research priorities workshop report Summary of the workshop organized in cooperation with US DOE and supported by EC JRC in Washington DC November 10-11 2014.

Energy Technology Data Exchange (ETDEWEB)

Jay Keller; Laura Hill; Kristian Kiuru; Groth, Katrina M.; Hecht, Ethan; Will James

2016-03-01

Tools (15%) 3. Indoor (13%) 4. Unintended Release-Liquid (11%) 5. Unintended Release-Gas (8%) 6. Storage (8%) 7. Integration Platforms (7%) 8. Hydrogen Safety Training (7%) 9. Materials Compatibility/Sensors (7%) 10. Applications (2%) The workshop participants ranked the need for Quantitative Risk Analysis (QRA) tools as the top priority by a large margin. QRA tools enable an informed expert to quantify the risk asso- ciated with a particular hydrogen system in a particular scenario. With appropriate verification and validation such tools will enable: * system designers to achieve a desired level of risk with suitable risk mitigation strategies, * permitting officials to determine if a particular system installation meets the desired risk level (performance based Regulations, Codes, and Standards (RCS) rather than prescrip- tive RCS), and * allow code developers to develop code language based on rigorous and validated physical models, statistics and standardized QRA methodologies. Another important research topic identified is the development of validated reduced physical models for use in the QRA tools. Improvement of the understanding and modeling of specific release phenomena, in particular liquid releases, are also highly ranked research topics. Acknowledgement The International Association HySafe, represented here by the authors, would like to thank all participants of the workshop for their valuable contributions. Particularly appreciated is the active participation of the industry representatives and the steady support by the European Com- mission's Joint Research Centre (JRC). Deep gratitude is owed for the great support by the United States Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy's Fuel Cell Technologies Office (EERE/FCTO) for the organization of the 2014 version of the hydrogen safety research priorities workshop. This page intentionally left blank.

Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus

Science.gov (United States)

Zafereo, Mark E.; Xu, Li; Dahlstrom, Kristina R.; Viamonte, Carlo A.; El-Naggar, Adel K.; Wei, Qingyi; Li, Guojun; Sturgis, Erich M.

2016-01-01

Objective Human papillomavirus (HPV) is a causal and prognostic factor for oropharyngeal cancer, but its role in squamous cell carcinoma of the oral cavity (SCCOC) is unclear. We sought to clarify HPV's role in SCCOC. Materials and Methods Patients with newly diagnosed SCCOC (N=460) were prospectively recruited, treated, and followed at one institution. p16/HPV status was determined by p16 immunohistochemistry (IHC) (N=210), PCR-based HPV 16/18 E6/7 DNA testing (N=403), and/or HPV in situ hybridization (ISH) (N=178). Kaplan-Meier curves and log-rank tests were used to compare survival by p16/HPV status. Results p16 expression was detected in 30% of tumors (62/210) and HPV 16/18 E6/7 DNA in 28% (114/403), although correlation between these two assays was poor (r=−0.01). Patients with p16-positive tumors were more likely to be younger and have primary tumors of the oral tongue. Only 4% of tumors (7/171) were positive for HPV by ISH. Comparisons of patients with p16-positive and p16-negative tumors, patients with HPV-positive and HPV-negative tumors by PCR, and patients with HPV-positive and HPV-negative tumors by ISH showed no significant differences in disease-specific or disease-free survival by p16/HPV status. When we applied a more stringent definition of HPV positivity based on a combination of assay results, only 10 of 166 tumors were HPV positive, and there were no significant differences in demographic, exposure, clinical, or survival characteristics between these patients and the 156 HPV-negative patients. Conclusions Very few patients with SCCOC have HPV-driven tumors. SCCOC that overexpresses p16 may be a unique subset deserving of further study. PMID:27086486

Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies

DEFF Research Database (Denmark)

de Kovel, Carolien G F; Trucks, Holger; Helbig, Ingo

2010-01-01

could be examined in 14 families. While 10 microdeletions were inherited (seven maternal and three paternal transmissions), four microdeletions occurred de novo at 15q13.3 (n = 1), 16p13.11 (n = 2) and 22q11.2 (n = 1). Eight of the transmitting parents were clinically unaffected, suggesting...... syndromes. The candidate microdeletions were assessed by high-density single nucleotide polymorphism arrays in 1234 patients with idiopathic generalized epilepsy from North-western Europe and 3022 controls from the German population. Microdeletions were validated by quantitative polymerase chain reaction.......2 (odds ratio = 4.9; 95% confidence interval 1.8-13.2; P = 4.2 x 10(-4)) and 16p13.11 (odds ratio = 7.4; 95% confidence interval 1.3-74.7; P = 0.009). Including nine patients with idiopathic generalized epilepsy in this cohort with known 15q13.3 microdeletions (IGE/control: 9/0), parental transmission...

Role of p16 testing in cervical cancer screening among HIV-infected women.

Directory of Open Access Journals (Sweden)

Christine J McGrath

Full Text Available p16 immunohistochemistry is used to evaluate for HPV-associated cervical intraepithelial neoplasia. The diagnostic performance of p16 in HIV infection is unclear.Between June-December 2009, HIV-infected women underwent Papanicolaou (Pap smear, human papillomavirus (HPV testing, visual inspection with acetic acid (VIA, and colposcopy-directed biopsy as the disease gold standard at a HIV clinic in Kenya. Pap smears were evaluated for p16 expression. Sensitivity, specificity, positive predictive value (PPV, and area under the receiver operating characteristic curve (AUC of p16 to detect CIN2/3 on histology and the impact of immunosuppression and ART was assessed.Of 331 cervical samples with p16 expression, p16 sensitivity and specificity to detect CIN2/3 was 54.1% and 72.4% respectively, which was lower than Pap and HPV in sensitivity, but higher in specificity than Pap, HPV, and VIA. Combining tests and p16 reduced sensitivity and increased specificity of Pap from 90.5% to 48.7% and 51.4% to 81.7%; of VIA from 59.5% to 37.8% and 67.6% to 89.9%; and of HPV from 82.4% to 50.0% and 55.3% to 84.8%. Combination p16 increased the PPV of Pap from 34.9% to 43.4%; of HPV from 34.7% to 48.7%; and VIA from 34.9% to 51.9%. Adjunctive p16 did not change AUC (P>0.05. P16 performance was not altered by immunosuppression or ART use. Combining p16 with HPV and VIA reduced the variation in HPV and VIA performance associated with CD4 and ART.As an adjunctive test in HIV-infected women, p16 immunohistochemistry increased specificity and PPV of HPV and VIA for CIN2/3, and was not altered in performance by immunosuppression, ART, or age.

Small changes in the atmospheric electric field from extensive air showers. [E > 10/sup 16/ eV

Energy Technology Data Exchange (ETDEWEB)

Bonino, G; Dardo, M [Turin Univ. (Italy); Pavese, P; Piano, A [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica

1977-05-28

The authors present data on small changes in the atmospheric electric field related to the passage of extensive air showers initiated by primary particles of energy >=10/sup 16/ eV. Such changes were detected by electrometric methods in conjunction with a particle shower array.

In Vivo Tes of Dicofol on Cocoon Production and Viability of Earthworm Pontoscolex corethrurus Fr. Mull

Science.gov (United States)

Sumarmin, R.; Huda, N. K.; Yuniarti, E.

2018-04-01

The uncontrol using of pesticides, harmful to the environment, health, and it would have impact to non-target animal as earthworm. This study describes the effect of the Dicofol to cocoon production and viability of earthworm Pontoscolex corethrurus Fr. Mull., has been done in-July - Augustus 2016 at the zoology laboratory of Biology Department of Universitas Negeri Padang. The experiment used the Completely Randomized Design (4 treatments 6 replications). The treatments are with 0 g / l (P1), 0.002 g / L (P2), 0.004 g / L (P3), and 0.006 g / L (P4) and 0.008 g / L of Dicofol that diluted to water. The Data of production and viability of earthworm cocoons Pontoscolex corethrurus Fr. Mull collected during 30 days in alternate day. Data analyzed by ANOVA and Duncan New Multiple Range Test at p <0.05. The results Showed that the average number of cocoons production at P1 30 cocoons (the highest), 16 cocoons P2, P3 7 cocoons, and the P4 and P5 0 cocoons (the Lowest). The average percentage of cocoons viability were highest in P1, and P2 (100%); P3 (10%) and the cancel at P4 and P5 (0%). It can conclude that the pesticide Dicofol decreased the production and viability of the earthworm cocoons Pontoscolex corethrurus Fr. Mull.

Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.

Science.gov (United States)

Cronise, Raymond J; Sinclair, David A; Bremer, Andrew A

2017-02-01

In most modern societies, the relationship that many individuals have with food has fundamentally changed from previous generations. People have shifted away from viewing food as primarily sustenance, and rather now seek out foods based on pure palatability or specific nutrition. However, it is far from clear what optimal nutrition is for the general population or specific individuals. We previously described the Food Triangle as a way to organize food based on an increasing energy density paradigm, and now expand on this model to predict the impact of oxidative priority and both nutrient and fiber density in relation to caloric load. When combined with meal frequency, integrated energy expenditure, macronutrient oxidative priority, and fuel partitioning expressed by the respiratory quotient, our model also offers a novel explanation for chronic overnutrition and the cause of excess body fat accumulation. Herein, we not only review how metabolism is a dynamic process subject to many regulators that mediate the fate of ingested calories but also discuss how the Food Triangle predicts the oxidative priority of ingested foods and provides a conceptual paradigm for healthy eating supported by health and longevity research.

Identification of sources of priority substances set out in Article 16 of the Water Framework Directive and estimation of their discharges into the German aquatic environment; Ermittlung der Quellen fuer die prioritaeren Stoffe nach Artikel 16 der Wasserrahmenrichtlinie und Abschaetzung ihrer Eintragsmengen in die Gewaesser in Deutschland

Energy Technology Data Exchange (ETDEWEB)

Boehm, E.; Hillenbrand, T.; Marscheider-Weidemann, F.; Mueller, B.; Wiederhold, J.; Herrchen, M.; Klein, M.

2002-12-01

The Water Framework Directive (2000/60/EC) is a new instrument, that inter alia has replaced, harmonized and further developed the control and reduction of point and diffuse discharges of dangerous substances according to Council Directive 76/464/EEC. Article 16 of the Water Framework Directive set out a 'Strategy against pollution of water' which demands specific measures against pollution of water by individual pollutants or groups of pollutants presenting a significant risk to or via the aquatic environment (e.g. by drinking water consumed). For these priority substances community-wide water quality standards and emission controls have to be established. On the basis of Article 16 of Directive 2000/60/EC a list of 33 priority substances has been adopted by the decision of the European Parliament and of the Council of November 2001. This list identifies 11 priority hazardous substances, 14 substances subject to a review for identification as possible priority hazardous substance and 8 priority substances. The Commission will make a proposal for the final classification of the 'substances subject to a review' (priority hazardous or priority substances) not later than 12 months after adoption of this list. The planned measures aim at the cessation or phasing out of discharges, emissions and losses to the aquatic environment within 20 years for the priority hazardous substances and at the progressive reduction for the priority substances. In this project the available data for these 33 substances resp. groups of substances for the Federal Republic of Germany were put forward and described in a standardized pattern. This pattern includes the following items: nomenclature and properties of the substances, monitoring data, production and fields of application of these substances, existing regulations in Germany, releases to environment and possibilities to reduce discharges to the aquatic environment. The basis of the data is the year 2000 as far as

76 FR 65653 - New Source Performance Standards (NSPS) Review

Science.gov (United States)

2011-10-24

... current within their review cycle, there are also multiple standards in different phases of the review... Rock Plants NN 04/16/1982 (47FR16589) 10/17/2000 3 4 (65FR61760) Polymeric Coating of Supporting VVV 09... whether review of a particular NSPS is necessary during the review cycle. A listing of any NSPS for which...

78 FR 26560 - Proposed Priority-National Institute on Disability and Rehabilitation Research-Rehabilitation...

Science.gov (United States)

2013-05-07

... in nonrural areas (U.S. Census Bureau, 2011b), and rural vocational rehabilitation clients with... priorities, we designate the type of each priority as absolute, competitive preference, or invitational...)). Competitive preference priority: Under a competitive preference priority, we give competitive preference to an...

16th World energy congress - No all clear signal; 16. Weltenergiekongress: Keine Entwarnung

Energy Technology Data Exchange (ETDEWEB)

Brabeck, A.

1995-11-07

The future organisation of the global energy supply was the central theme of the 16th Congress of the World Energy Council, which was held from 8 to 13 October 1995 in Tokyo. Under the basic theme ``Energy for our common world - what will the future ask for us`` ecological and development policy aspects were also included in the discussion of energy policy. Because of these relationships and the importance of the subject also for the future of the German mining industry Glueckauf is reproducing below two publications issued in connection with the World Energy Conference. (orig.) [Deutsch] Die zukuenftige Gestaltung der globalen Energieversorgung war Kernthema des 16. Kongresses des Weltenergierates, der vom 8. bis 13. Oktober 1995 in Tokio stattfand. Unter dem Leitmotiv ``Energy for our common world - what will the future ask of us`` wurden gerade auch oekologische und entwicklungspolitische Aspekte in die energiepolitische Diskussion einbezogen. Aufgrund dieser Zusammenhaenge und der Bedeutung dieser Thematik auch fuer die Zukunft der deutschen Bergbauindustrie, gibt GLUeCKAUF nachfolgend zwei Veroeffentlichungen zur Weltenergiekonferenz im Wortlaut wieder: Zum einen eine Presseinformation des Deutschen Nationalen Komitees des Weltenergierates vom 12. Oktober 1995 mit dem Titel ``Fortschritte; aber noch keine Entwarnung`` und zum anderen ein Statement von Dipl.-Kfm. Guenter Meyhoefer, Vorstandsvorsitzender des Eschweiler Bergwerks-Vereins AG, Herzogenrath, Generalbevollmaechtigter der Ruhrkohle AG, Essen, und Vizepraesident des Gesamtverbands des deutschen Steinkohlenbergbaus, Essen. (orig.)

Ambition, policy and consistency. The ins and outs of 16% sustainable energy in 2020; Ambitie, beleid en consistentie. Het ABC van 16% Duurzame Energie in 2020

Energy Technology Data Exchange (ETDEWEB)

Kaat, A.

2013-01-15

This memo outlines the options to realize the target of 16% sustainable energy for 2020 via production in the Netherlands [Dutch] De notitie verkent de oplossingen om via productie in Nederland de doelstelling voor duurzame energie te halen: 16% in 2020.

Species of Hypholoma (Fr. P. Kumm. (Strophariaceae, Agaricales in Rio Grande do Sul State, Brazil Espécies de Hypholoma (Fr. P. Kumm. (Strophariaceae, Agaricales no Rio Grande do Sul, Brasil

Directory of Open Access Journals (Sweden)

Vagner Gularte Cortez

2007-09-01

Full Text Available Detailed descriptions, illustrations, discussions and a key for identification of the known species of the genus Hypholoma (Fr. P. Kumm. in Rio Grande do Sul state are presented, as well as a revision of the Hypholoma specimens deposited in the Fungi Rickiani collection. Based on the authors' collections and the herbarium revision, the following species were recognized: H. aurantiacum (Cooke Faus, H. ericaeum (Pers.: Fr. Kühner, and H. subviride (Berk. & M.A. Curtis Dennis.Neste trabalho são apresentadas descrições, ilustrações, discussões e chave de identificação para as espécies do gênero Hypholoma (Fr. P. Kumm. conhecidas no estado do Rio Grande do Sul, além de uma revisão do material de Hypholoma depositado na coleção Fungi Rickiani. A partir das coletas realizadas pelos autores, bem como estudo do material depositado nos principais herbários do estado e do país, verificou-se a ocorrência das seguintes espécies: H. aurantiacum (Cooke Faus, H. ericaeum (Pers.: Fr. Kühner e H. subviride (Berk. & M.A. Curtis Dennis.

Prognostic Significance of p16 Expression in Advanced Cervical Cancer Treated With Definitive Radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Schwarz, Julie K., E-mail: jschwarz@radonc.wustl.edu [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO (United States); Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (United States); Lewis, James S. [Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (United States); Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO (United States); Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (United States); Pfeifer, John [Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (United States); Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO (United States); Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (United States); Huettner, Phyllis [Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (United States); Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO (United States); Grigsby, Perry [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO (United States); Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (United States); Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (United States)

2012-09-01

Purpose: The purpose of this study was to evaluate the prognostic significance of p16 immunohistochemistry (IHC) in patients with advanced cervical cancer treated with radiation therapy. Materials and Methods: This was a retrospective study of 126 patients with International Federation of Gynecology and Obstetrics Stages Ib1-IVb cervical cancer treated with radiation. Concurrent cisplatin chemotherapy was given to 108 patients. A tissue microarray (TMA) was constructed from the paraffin-embedded diagnostic biopsy specimens. Immunoperoxidase staining was performed on the TMA and a p16 monoclonal antibody was utilized. IHC p16 extent was evaluated and scored in quartiles: 0 = no staining, 1 = 1-25% of cells staining, 2 = 26 to 50%, 3 = 51 to 75%, and 4 = 76 to 100%. Results: The p16 IHC score was 4 in 115 cases, 3 in 1, 2 in 3 and 0 in 7. There was no relationship between p16 score and tumor histology. Patients with p16-negative tumors were older (mean age at diagnosis 65 vs. 52 years for p16-positive tumors; p = 0.01). The 5-year cause-specific survivals were 33% for p16-negative cases (score = 0) compared with 63% for p16-positive cases (scores 1, 2, 3 or 4; p = 0.07). The 5-year recurrence-free survivals were 34% for those who were p16-negative vs. 57% for those who were p16-positive (p = 0.09). In addition, patients with p16-positive tumors (score > 0) were more likely to be complete metabolic responders as assessed by the 3-month posttherapy 18 [F]-fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomograph compared with patients with p16-negative tumors (p = 0.03). Conclusion: p16 expression is predictive of improved survival outcome after chemoradiation therapy for advanced-stage invasive cervical carcinoma. Further testing will be needed to evaluate p16-negative cervical tumors.

10 CFR 871.2 - Public health and safety exemption.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Public health and safety exemption. 871.2 Section 871.2 Energy DEPARTMENT OF ENERGY AIR TRANSPORTATION OF PLUTONIUM § 871.2 Public health and safety exemption... property damage, or other significant threat to the public health and safety. [42 FR 48332, Sept. 23, 1977...

Report the Africa renewable energy initiative launched at COP21

International Nuclear Information System (INIS)

Royal, Segolene

2016-09-01

Segolene Royal, President of COP21, presents in this report the specific renewable energy projects to be embarked on in Africa without delay. On the basis of the COP21 President's visits to 17 African countries, her discussions with African leaders and analysis by groups of experts, a list of 240 projects accounting for more than 45 GW of renewable capacity is being made public: 13 geothermal energy projects: 7 GW; 58 hydroelectricity projects: 20 GW; 62 solar energy projects: 6 GW; 16 wind energy projects: 5 GW; 35 projects combining more than one technology: 1 GW; 4 national strategies (solar and wind energy): 8 GW. Launched by African heads of state on 1 December 2015 in the presence of French President Francois Hollande, the Africa Renewable Energy Initiative aims to increase the continent's installed capacity of renewable energy by 10 GW by 2020 and 300 GW by 2030. During COP21. To achieve this goal, Segolene Royal has pledged to facilitate the implementation of the initiative throughout the French COP21 presidency. The report proposes a review of the energy situation in Africa and sets out 10 recommendations to speed up the deployment of renewable energy on the continent: 1. To identify a list of priority projects to implement by 2020, and projects to begin before and during COP22; 2. To bring the partners together around each project to share out responsibilities; 3. To initiate dialogue with the private sector about the initiative and projects; 4. To strengthen participatory citizenship regarding energy; 5. To involve African women in renewable energy; 6. To draw on the International Solar Alliance, launched at COP21, and the Global Geothermal Alliance; 7. To put in place innovative financial instruments, such as loan-grant blending; 8. To allow for climate change in the projects; 9. To strengthen the independent body responsible for implementing the initiative, hosted and supported by the African Development Bank; 10. To finalize a map of existing

Study of deuteron break-up at low energies in the reactions D(d,pn)d and D(d,dn)p

International Nuclear Information System (INIS)

Cocu, Francis; Ambrosino, Georges; Guerreau, Daniel.

1977-06-01

Quasi-free scattering in the reactions d+D=n+p+d has been studied at incident energies between 7 and 12 MeV by steps of 1 MeV. In a kinematically complete experiment, the cross sections were measured for the coincidences (p,n) and for the coincidences (d,n). The energy of the charged particle was also enregistered. The detector of the charged particles was put at an angle thetasub(p)=thetasub(d)=19 0 5 counted from the incident axis, the detector of neutrons at thetasub(n)=-30 0 . The geometry was coplanar. Pure gaseous target gives an excellent signal/back-ground ratio. The measure of the time-of-flight of the neutron allows indirectly the discrimination of the nature of the detected charged particle. Absolute cross sections are compared with the results of the complete Born approximation. The nucleon-nucleon potential is spin-dependant. The shape of the measured (d,n) spectra is fairly well reproduced but not its intensity. The (p,n) spectra is not so well reproduced but the distortion diminishes on increasing the incident energy [fr

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

Science.gov (United States)

Jacquemont, Sébastien; Reymond, Alexandre; Zufferey, Flore; Harewood, Louise; Walters, Robin G.; Kutalik, Zoltán; Martinet, Danielle; Shen, Yiping; Valsesia, Armand; Beckmann, Noam D.; Thorleifsson, Gudmar; Belfiore, Marco; Bouquillon, Sonia; Campion, Dominique; De Leeuw, Nicole; De Vries, Bert B. A.; Esko, Tõnu; Fernandez, Bridget A.; Fernández-Aranda, Fernando; Fernández-Real, José Manuel; Gratacòs, Mònica; Guilmatre, Audrey; Hoyer, Juliane; Jarvelin, Marjo-Riitta; Kooy, Frank R.; Kurg, Ants; Le Caignec, Cédric; Männik, Katrin; Platt, Orah S.; Sanlaville, Damien; Van Haelst, Mieke M.; Villatoro Gomez, Sergi; Walha, Faida; Wu, Bai-Lin; Yu, Yongguo; Aboura, Azzedine; Addor, Marie-Claude; Alembik, Yves; Antonarakis, Stylianos E.; Arveiler, Benoît; Barth, Magalie; Bednarek, Nathalie; Béna, Frédérique; Bergmann, Sven; Beri, Mylène; Bernardini, Laura; Blaumeiser, Bettina; Bonneau, Dominique; Bottani, Armand; Boute, Odile; Brunner, Han G.; Cailley, Dorothée; Callier, Patrick; Chiesa, Jean; Chrast, Jacqueline; Coin, Lachlan; Coutton, Charles; Cuisset, Jean-Marie; Cuvellier, Jean-Christophe; David, Albert; De Freminville, Bénédicte; Delobel, Bruno; Delrue, Marie-Ange; Demeer, Bénédicte; Descamps, Dominique; Didelot, Gérard; Dieterich, Klaus; Disciglio, Vittoria; Doco-Fenzy, Martine; Drunat, Séverine; Duban-Bedu, Bénédicte; Dubourg, Christèle; El-Sayed Moustafa, Julia S.; Elliott, Paul; Faas, Brigitte H. W.; Faivre, Laurence; Faudet, Anne; Fellmann, Florence; Ferrarini, Alessandra; Fisher, Richard; Flori, Elisabeth; Forer, Lukas; Gaillard, Dominique; Gerard, Marion; Gieger, Christian; Gimelli, Stefania; Gimelli, Giorgio; Grabe, Hans J.; Guichet, Agnès; Guillin, Olivier; Hartikainen, Anna-Liisa; Heron, Délphine; Hippolyte, Loyse; Holder, Muriel; Homuth, Georg; Isidor, Bertrand; Jaillard, Sylvie; Jaros, Zdenek; Jiménez-Murcia, Susana; Joly Helas, Géraldine; Jonveaux, Philippe; Kaksonen, Satu; Keren, Boris; Kloss-Brandstätter, Anita; Knoers, Nine V. A. M.; Koolen, David A.; Kroisel, Peter M.; Kronenberg, Florian; Labalme, Audrey; Landais, Emilie; Lapi, Elisabetta; Layet, Valérie; Legallic, Solenn; Leheup, Bruno; Leube, Barbara; Lewis, Suzanne; Lucas, Josette; Macdermot, Kay D.; Magnusson, Pall; Marshall, Christian R.; Mathieu-Dramard, Michèle; Mccarthy, Mark I.; Meitinger, Thomas; Antonietta Mencarelli, Maria; Merla, Giuseppe; Moerman, Alexandre; Mooser, Vincent; Morice-Picard, Fanny; Mucciolo, Mafalda; Nauck, Matthias; Coumba Ndiaye, Ndeye; Nordgren, Ann; Pasquier, Laurent; Petit, Florence; Pfundt, Rolph; Plessis, Ghislaine; Rajcan-Separovic, Evica; Paolo Ramelli, Gian; Rauch, Anita; Ravazzolo, Roberto; Reis, Andre; Renieri, Alessandra; Richart, Cristobal; Ried, Janina S.; Rieubland, Claudine; Roberts, Wendy; Roetzer, Katharina M.; Rooryck, Caroline; Rossi, Massimiliano; Saemundsen, Evald; Satre, Véronique; Schurmann, Claudia; Sigurdsson, Engilbert; Stavropoulos, Dimitri J.; Stefansson, Hreinn; Tengström, Carola; Thorsteinsdóttir, Unnur; Tinahones, Francisco J.; Touraine, Renaud; Vallée, Louis; Van Binsbergen, Ellen; Van Der Aa, Nathalie; Vincent-Delorme, Catherine; Visvikis-Siest, Sophie; Vollenweider, Peter; Völzke, Henry; Vulto-Van Silfhout, Anneke T.; Waeber, Gérard; Wallgren-Pettersson, Carina; Witwicki, Robert M.; Zwolinksi, Simon; Andrieux, Joris; Estivill, Xavier; Gusella, James F.; Gustafsson, Omar; Metspalu, Andres; Scherer, Stephen W.; Stefansson, Kari; Blakemore, Alexandra I. F.; Beckmann, Jacques S.; Froguel, Philippe

2011-01-01

Both underweight and obesity have been associated with increased mortality1,2. Underweight, defined as body mass index (BMI) ≤ 18,5 kg/m2 in adults 3 and ≤ −2 standard deviations (SD) in children4,5, is the main sign of a series of heterogeneous clinical conditions such as failure to thrive (FTT) 6–8, feeding and eating disorder and/or anorexia nervosa9,10. In contrast to obesity, few genetic variants underlying these clinical conditions have been reported 11, 12. We previously demonstrated that hemizygosity of a ~600 kb region on the short arm of chromosome 16 (chr16:29.5–30.1Mb), causes a highly-penetrant form of obesity often associated with hyperphagia and intellectual disabilities13. Here we show that the corresponding reciprocal duplication is associated with underweight. We identified 138 (132 novel cases) duplication carriers (108 unrelated carriers) from over 95,000 individuals clinically-referred for developmental or intellectual disabilities (DD/ID), psychiatric disorders or recruited from population-based cohorts. These carriers show significantly reduced postnatal weight (mean Z-score −0.6; p=4.4×10−4) and BMI (mean Z-score −0.5; p=2.0×10−3). In particular, half of the boys younger than 5 years are underweight with a probable diagnosis of FTT, while adult duplication carriers have an 8.7-fold (p=5.9×10−11; CI_95=[4.5–16.6]) increased risk of being clinically underweight. We observe a significant trend towards increased severity in males, as well as a depletion of male carriers among non-medically ascertained cases. These features are associated with an unusually high frequency of selective and restrictive feeding behaviours and a significant reduction in head circumference (mean Z-score −0.9; p=7.8×10−6). Each of the observed phenotypes is the converse of one reported in carriers of deletions at this locus, correlating with changes in transcript levels for genes mapping within the duplication but not within flanking

Measurement of D(d,p)T Reaction Cross Sections in Sm Metal in Low Energy Region (10(≤) Ed(≤)20 keV)

Institute of Scientific and Technical Information of China (English)

WANG Tie-Shan; YANG Zhen; H. Yunemura; A. Nakagawa; LV Hui-Yi; CHEN Jian-Yong; LIU Sheng-Jin; J. Kasagi

2007-01-01

To study the screening effect of nuclear reactions in metallic environments, the thick target yields, the cross sections and the experimental S(E) factors of the D{d,p)T reaction have been measured on deuterons implanted in Sm metal at 133.2 K for beam energies ranging from 10 to 20keV. The thick target yields of protons emitted in the D(d,p)T reaction are measured and compared with those data extrapolated from cross sections and stopping power data at higher energies. The screening potential in Sm metal at 133.2K is deduced to be 520±56eV. As compared with the value achieved in the gas target, the calculated screening potential values are much larger. This screening potential cannot be simply interpreted only by the electron screening. Energy dependences of the cross section cr(E) and the experimental S(E) factor for D(d,p)T reaction in Sm metal at 133.2K are obtained, respectively.

77 FR 59184 - J.P. Morgan Ventures Energy Corporation; Notice of Initiation of Proceeding and Refund Effective...

Science.gov (United States)

2012-09-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-103-000] J.P. Morgan... statements by J.P. Morgan Ventures Energy Corporation constitute violations of section 35.41(b) of the Commission's regulations under the Federal Power Act (FPA).\\1\\ J.P. Morgan Ventures Energy Corporation, 140...

78 FR 58322 - National Cancer Institute; Amended Notice of Meeting

Science.gov (United States)

2013-09-23

... Institute Special Emphasis Panel, November 06, 2013, 06:30 p.m. to November 07, 2013, 04:00 p.m., Hilton... August 16, 2013, 78 FR 50065. The meeting notice is amended to change the location from the Hilton...

Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase.

Directory of Open Access Journals (Sweden)

Hye-Ryung Choi

Full Text Available Brown adipocytes play an important role in regulating the balance of energy, and as such, there is a strong correlation between obesity and the amount of brown adipose tissue. Although the molecular mechanism underlying white adipocyte differentiation has been well characterized, brown adipocyte differentiation has not been studied extensively. Here, we investigate the potential role of dual-specificity phosphatase 10 (DUSP10 in brown adipocyte differentiation using primary brown preadipocytes.The expression of DUSP10 increased continuously after the brown adipocyte differentiation of mouse primary brown preadipocytes, whereas the phosphorylation of p38 was significantly upregulated at an early stage of differentiation followed by steep downregulation. The overexpression of DUSP10 induced a decrease in the level of p38 phosphorylation, resulting in lower lipid accumulation than that in cells overexpressing the inactive mutant DUSP10. The expression levels of several brown adipocyte markers such as PGC-1α, UCP1, and PRDM16 were also significantly reduced upon the ectopic expression of DUSP10. Furthermore, decreased mitochondrial DNA content was detected in cells expressing DUSP10. The results obtained upon treatment with the p38 inhibitor, SB203580, clearly indicated that the phosphorylation of p38 at an early stage is important in brown adipocyte differentiation. The effect of the p38 inhibitor was partially recovered by DUSP10 knockdown using RNAi.These results suggest that p38 phosphorylation is controlled by DUSP10 expression. Furthermore, p38 phosphorylation at an early stage is critical in brown adipocyte differentiation. Thus, the regulation of DUSP10 activity affects the efficiency of brown adipogenesis. Consequently, DUSP10 can be used as a novel target protein for the regulation of obesity.

Modeling for climate change in the aspect of nuclear energy priority: Nuclear power energy-based convergence social-humanity analysis

Energy Technology Data Exchange (ETDEWEB)

Woo, Tae Ho [Systemix Global Co. Ltd., Seoul, (Korea, Republic of)

2015-05-15

Following the industry expansion, the energy consumptions have increased steeply, which have produced the global warming in our lives by carbon production energies. This climate change has provoked significant natural disasters which have damaged to social as well economic matters. Considering the non-carbon production which is the major factor of global warming, nuclear energy is a newly spotlighted source as the green energy source. The climate change factor is affected by the carbon productions made by humans. Then, the nuclear energy increasing rate with the climate change factor affects to the temperature change which is expressed by annual anomaly. Fig. 6 is the protocol for climate change investigation incorporated with the nuclear industry where the climate factor like the temperature is an important index to find out the priority of nuclear energy. The increased environmental pollutions can give the expanding of nuclear energy due to the carbon gas of fossil fuels. This study showed the effectiveness of the nuclear energy by the simulations. The seasonal climate disaster like the very cold winter and very hot summer can increase the necessity of nuclear energy development which could appeal to the general public persons as well as the politicians. So, it is important for the nuclear energy manager to make people understand the importance of the nuclear energy comparing to the oil or coal fuels. The regeneration energy has been considered as the alternative source.

Synthesis and characterization of a molecularly imprinted polymer for the isolation of the 16 US-EPA priority polycyclic aromatic hydrocarbons (PAHs) in solution.

Science.gov (United States)

Ncube, Somandla; Kunene, Phumlile; Tavengwa, Nikita T; Tutu, Hlanganani; Richards, Heidi; Cukrowska, Ewa; Chimuka, Luke

2017-09-01

A smart sorbent consisting of benzo[k]fluoranthene-imprinted and indeno[1 2 3-cd]pyrene-imprinted polymers mixed at 1:1 (w/w) was successfully screened from several cavity-tuning experiments and used in the isolation of polycyclic aromatic hydrocarbons from spiked solution. The polymer mixture showed high cross selectivity and affinity towards all the 16 US-EPA priority polycyclic aromatic hydrocarbons. The average extraction efficiency from a cyclohexane solution was 65 ± 13.3% (n = 16, SD). Batch adsorption and kinetic studies confirmed that the binding of polycyclic aromatic hydrocarbons onto the polymer particles resulted in formation of a monolayer and that the binding process was the rate limiting step. The imprinted polymer performance studies confirmed that the synthesized polymer had an imprinting efficiency of 103.9 ± 3.91% (n = 3, SD). A comparison of the theoretical number of cavities and the experimental binding capacity showed that the overall extent of occupation of the imprinted cavities in the presence of excess polycyclic aromatic hydrocarbons was 128 ± 6.45% (n = 3, SD). The loss of selectivity was estimated at 2.9% with every elution cycle indicating that the polymer can be re-used several times with limited loss of selectivity and sensitivity. The polymer combination has shown to be an effective adsorbent that can be used to isolate all the 16 US-EPA priority polycyclic aromatic hydrocarbons in solution. Copyright © 2017 Elsevier Ltd. All rights reserved.

p16/CDKN2A FISH in Differentiation of Diffuse Malignant Peritoneal Mesothelioma From Mesothelial Hyperplasia and Epithelial Ovarian Cancer.

Science.gov (United States)

Ito, Tomohiro; Hamasaki, Makoto; Matsumoto, Shinji; Hiroshima, Kenzo; Tsujimura, Tohru; Kawai, Toshiaki; Shimao, Yoshiya; Marutsuka, Kousuke; Moriguchi, Sayaka; Maruyama, Riruke; Miyamoto, Shingo; Nabeshima, Kazuki

2015-06-01

It can be difficult to differentiate diffuse malignant peritoneal mesothelioma (DMPM) from reactive mesothelial hyperplasia (RMH) or peritoneal dissemination of gynecologic malignancies, such as epithelial ovarian cancer (EOC), which cause a large amount of ascites. Detection of the homozygous deletion of p16/CDKN2A (p16) by fluorescence in situ hybridization (FISH) is an effective adjunct in the diagnosis of malignant pleural mesothelioma. The aim of this study was to investigate the ability of the p16 FISH assay to differentiate DMPM from RMH and EOC. p16 FISH was performed in 28 DMPMs (successful in 19), 30 RMHs, and 40 EOC cases. The cutoff values of p16 FISH were more than 10% for homozygous deletion and more than 40% for heterozygous deletion. According to the above criteria, nine (47.4%) of 19 successful DMPM cases were homozygous deletion positive, and three (15.8%) of 19 were heterozygous deletion positive, whereas all RMH cases were negative for the p16 deletion. In all four major histologic subtypes of EOC, neither p16 homozygous nor heterozygous deletions were detected. To differentiate DMPM from RMH or EOC, the sensitivity of the p16 homozygous deletion was 32% (9/28), and the specificity was 100%. Our study suggests that p16 FISH analysis is useful in differentiating DMPM from RMH and EOC when homozygous deletion is detected. Copyright© by the American Society for Clinical Pathology.

The Creatine Transporter Gene Paralogous at 16p11.2 Is Expressed in Human Brain

Directory of Open Access Journals (Sweden)

Nadia Bayou

2008-01-01

We report on the clinical, cytogenetic, and molecular findings in a boy with autism carrying a de novo translocation t(7;16(p22.1;p11.2. The chromosome 16 breakpoint disrupts the paralogous SLC6A8 gene also called SLC6A10 or CT2. Predicted translation of exons and RT-PCR analysis reveal specific expression of the creatine transporter paralogous in testis and brain. Several studies reported on the role of X-linked creatine transporter mutations in individuals with mental retardation, with or without autism. The existence of disruption in SLC6A8 paralogous gene associated with idiopathic autism suggests that this gene may be involved in the autistic phenotype in our patient.

Energy dependence of the stopping power of MeV 16O ions in a laser-produced plasma

International Nuclear Information System (INIS)

Sakumi, A.; Shibata, K.; Sato, R.; Tsubuku, K.; Nishimoto, T.; Hasegawa, J.; Ogawa, M.; Oguri, Y.; Katayama, T.

2001-01-01

The energy dependence of the stopping power of 16 O ions in a laser-produced plasma target was experimentally investigated in the projectile energy range of 150-350 keV/u. In order to produce the target plasma a Q-Switched Nd-glass laser was focused onto a small lithium hydride (LiH) pellet. The plasma electron temperature and the electron line density were 15 eV and 2x10 17 cm -2 , respectively. The energy loss of 16 O ions in the plasma was measured by a time-of-flight (TOF) method. We found that the stopping power in the plasma agreed with the theoretical estimation based on a modified Bohr equation with correction at low velocities. In this evaluation, the effective charge of the projectile was calculated by means of rate equations on the loss and capture of electrons. It has been also found that in this projectile energy range the stopping power of the 16 O ions in the plasma still increases with decreasing projectile energy, while it decreases in cold equivalent

Cloning and expression of the coding regions of the heat shock proteins HSP10 and HSP16 from Piscirickettsia salmonis

Directory of Open Access Journals (Sweden)

VIVIAN WILHELM

2003-01-01

Full Text Available The genes encoding the heat shock proteins HSP10 and HSP16 of the salmon pathogen Piscirickettsia salmonis have been isolated and sequenced. The HSP10 coding sequence is located in an open reading frame of 291 base pairs encoding 96 aminoacids. The HSP16 coding region was isolated as a 471 base pair fragment encoding a protein of 156 aminoacids. The deduced aminoacid sequences of both proteins show a significant homology to the respective protein from other prokaryotic organisms. Both proteins were expressed in E. coli as fusion proteins with thioredoxin and purified by chromatography on Ni-column. A rabbit serum against P. salmonis total proteins reacts with the recombinant HSP10 and HSP16 proteins. Similar reactivity was determined by ELISA using serum from salmon infected with P. salmonis. The possibility of formulating a vaccine containing these two proteins is discussed

Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon

Science.gov (United States)

Elder age and chronic alcohol consumption are important risk factors for the development of colon cancer. Each factor can alter genomic and gene-specific DNA methylation. This study examined the effects of aging and chronic alcohol consumption on genomic and p16-specific methylation, and p16 express...

Applying dynamic priority scheduling scheme to static systems of pinwheel task model in power-aware scheduling.

Science.gov (United States)

Seol, Ye-In; Kim, Young-Kuk

2014-01-01

Power-aware scheduling reduces CPU energy consumption in hard real-time systems through dynamic voltage scaling (DVS). In this paper, we deal with pinwheel task model which is known as static and predictable task model and could be applied to various embedded or ubiquitous systems. In pinwheel task model, each task's priority is static and its execution sequence could be predetermined. There have been many static approaches to power-aware scheduling in pinwheel task model. But, in this paper, we will show that the dynamic priority scheduling results in power-aware scheduling could be applied to pinwheel task model. This method is more effective than adopting the previous static priority scheduling methods in saving energy consumption and, for the system being still static, it is more tractable and applicable to small sized embedded or ubiquitous computing. Also, we introduce a novel power-aware scheduling algorithm which exploits all slacks under preemptive earliest-deadline first scheduling which is optimal in uniprocessor system. The dynamic priority method presented in this paper could be applied directly to static systems of pinwheel task model. The simulation results show that the proposed algorithm with the algorithmic complexity of O(n) reduces the energy consumption by 10-80% over the existing algorithms.

Study of function response of a detector HPGe to photons of reaction 19F(p,αγ)16O

International Nuclear Information System (INIS)

Tridapalli, D.B.

2006-01-01

In the 19 F(p,αγ) 16 O reaction, characteristic gamma-rays with energies: 6.1 MeV; 6.9 MeV and 7.1 keV can be observed. These photons can be used in many important applications such as Proton Induced Gamma-ray Emission (PIGE), gamma radiography and calibration purposes. It has another advantage in calibration procedures, which is the observed photon flux is greater than other reactions studied, 27 Al(p,αγ) 28 Si and 23 Na(p,αγ) 24 Mg. In our laboratory, we are studying the efficiency and response function of HPGe detectors for high energy photons, and for this it is necessary a source with a level scheme with few gamma-ray transitions and known relative yields. The 19 F(p,αγ) 16 O reaction satisfies the first condition but in the literature we found relative yields for thick targets or reaction cross section for thin targets. However, we use targets of intermediate thickness, therefore in this work we measure the relative gamma-ray yields for protons with energies between 1.36 MeV and 1.42 MeV. The experiments were performed at the 1.7 MV Pelletron tandem accelerator of the Laboratorio de Analise de Materiais por Feixes Ionicos (LAMFI) located at Instituto de Fisica da Universidade de Sao Paulo, using a reverse-electrode closed-end coaxial HPGe detector with 72.5 mm in diameter and 60.5 mm in length, at 0 deg. The proton irradiation current was 50 nA, and the target consisted of 250 μg/cm 2 CaF 2 evaporated on a 0.1 mm Ta backing. In this reaction the 20 Ne resonant state fissions in flight, and the resulting 16 O excited states have different half-lives; all observed peaks are deformed due to either Doppler broadening from 16 O random velocity direction or Doppler shift from nuclei that leave the target toward the vacuum chamber. Moreover, the peak deformations vary with the proton energy. These deformations were modeled by a Monte Carlo simulation that follows the oxygen nuclei in its trajectory until photon emission, considering the changes in spatial

10 CFR 611.206 - Existing facilities.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Existing facilities. 611.206 Section 611.206 Energy... PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing facilities, give priority to those facilities that are oldest or...

P-type conduction in Mg-doped GaN treated with low-energy electron beam irradiation (LEEBI)

International Nuclear Information System (INIS)

Amano, Hiroshi; Kito, Masahiro; Hiramatsu, Kazumasa

1989-01-01

Distinct p-type conduction is realized with Mg-doped GaN by the low-energy electron-beam irradiation (LEEBI) treatment, and the properties of the GaN p-n junction LED are reported for the first time. It was found that the LEEBI treatment drastically lowers the resistivity and remarkably enhances the PL efficiency of MOVPE-grown Mg-doped GaN. The Hall effect measurement of this Mg-doped GaN treated with LEEBI at room temperature showed that the hole concentration is ∼2·10 16 cm -3 , the hole mobility is ∼8 cm 2 /V·s and the resistivity is ∼35Ω· cm. The p-n junction LED using Mg-doped GaN treated with LEEBI as the p-type material showed strong near-band-edge emission due to the hole injection from the p-layer to the n-layer at room temperature. (author)

High Resolution Spectroscopy of 16N#Lambda# by Electroproduction

International Nuclear Information System (INIS)

Cusanno, Francesco; Urciuoli, Guido; Acha Quimper, Armando; Ambrozewicz, Pawel; Aniol, Konrad; Baturin, Pavlo; Bertin, Pierre; Benaoum, Hachemi; Blomqvist, Ingvar; Boeglin, Werner; Breuer, Herbert; Brindza, Paul; Bydzovsky, Petr; Camsonne, Alexandre; Chang, C.; Chang, C.C.; Chen, Jian-Ping; Choi, Seonho; Chudakov, Eugene; Cisbani, Evaristo; Colilli, Stefano; Coman, Luminita; Craver, Brandon; de Cataldo, Giacinto; De Jager, Cornelis; De Leo, Raffaele; Deur, Alexandre; Ferdi, Catherine; Feuerbach, Robert; Folts, Edward; Frullani, Salvatore; Garibaldi, Franco; Gayou, Olivier; Giuliani, Fausto; Gomez, Javier; Gricia, Massimo; Hansen, Jens-Ole; Hayes, David; Higinbotham, Douglas; Holmstrom, Timothy; Hyde, Charles; Ibrahim, Hassan; Iodice, Mauro; Jiang, Xiaodong; Kaufman, Lisa; Kino, Kouichi; Kross, Brian; Lagamba, Luigi; LeRose, John; Lindgren, Richard; Lucentini, Maurizio; Margaziotis, Demetrius; Markowitz, Pete; Marrone, Stefano; Meziani, Zein-Eddine; McCormick, Kathy; Michaels, Robert; Millener, D.; Miyoshi, Toshinobu; Moffit, Bryan; Monaghan, Peter; Moteabbed, Maryam; Munoz Camacho, Carlos; Nanda, Sirish; Nappi, E.; Nelyubin, Vladimir; Norum, Blaine; Okasyasu, Y.; Paschke, Kent; Perdrisat, Charles; Piasetzky, Eliazer; Punjabi, Vina; Qiang, Yi; Raue, Brian; Reimer, Paul; Reinhold, Joerg; Reitz, Bodo; Roche, Rikki; Rodriguez, Victor; Saha, Arunava; Santavenere, Fabio; Sarty, Adam; Segal, John; Shahinyan, Albert; Singh, Jaideep; Sirca, Simon; Snyder, Ryan; Solvignon, Patricia; Sotona, M.; Sotona, Miloslav; Subedi, Ramesh; Sulkosky, Vince; Sulkosky, Vincent; Suzuki, Tomokazu; Ueno, Hiroaki; Ulmer, Paul; Veneroni, P.P.; Voutier, Eric; Wojtsekhowski, Bogdan; Zeng, X.; Zorn, Carl

2009-01-01

An experimental study of the 16O(e, e'K+)16N # Lambda# reaction has been performed at Jefferson Lab. A thin film of falling water was used as a target. This permitted a simultaneous measurement of the p(e, e'K+)Λ,Σ 0 exclusive reactions and a precise calibration of the energy scale. A ground-state binding energy of 13.76 ± 0.16 MeV was obtained for 16N # Lambda# with better precision than previous measurements on the mirror hypernucleus 16O # Lambda#. Precise energies have been determined for peaks arising from a Lambda in s and p orbits coupled to the p1/2 and p3/2 hole states of the 15N core nucleus.

High-level pullulan production by Aureobasidium pullulans var. melanogenium P16 isolated from mangrove system.

Science.gov (United States)

Ma, Zai-Chao; Fu, Wen-Juan; Liu, Guang-Lei; Wang, Zhi-Peng; Chi, Zhen-Ming

2014-06-01

After over 100 strains of Aureobasidium spp. isolated from mangrove system were screened for their ability to produce exopolysaccharide (EPS), it was found that Aureobasidium pullulans var. melanogenium P16 strain among them could produce high level of EPS. Under the optimal conditions, 65.3 g/L EPS was produced by the P16 strain within 120 h at flask level. During 10-L batch fermentation, when the medium contained 120.0 g/L sucrose, 67.4 g/L of EPS and 23.1 g/L of cell dry weight in the culture were obtained within 120 h, leaving 0.78 g/L of reducing sugar and 11.4 g/L of total sugar in the fermented medium. It should be stressed that during the fermentation, no melanin was observed. After purification, the purified EPS was confirmed to be pullulan. This is the first time to report that A. pullulans var. melanogenium P16 strain isolated from the mangrove system can produce high level of pullulan.

Relationship between HPV infection/p16 expression and radiotherapy prognosis in oropharyngeal squamous cell carcinoma

International Nuclear Information System (INIS)

Qu Yuan; Gao Li; Yi Junlin; Huang Xiaodong; Luo Jingwei; Zhang Shiping; Wang Kai; Xu Guozhen

2014-01-01

Objective: To investigate the relationship between human papillomavirus (HPV) infection/p16 expression and radiotherapy prognosis in oropharyngeal squamous cell carcinoma (OSCC) and the prognostic value of p16 in OSCC patients treated with radiotherapy. Methods: Tissue samples were collected from 42 patients newly diagnosed with OSCC in our hospital from January 1999 to December 2008. PCR was performed to detect HPV DNA, and p16 expression was measured by immunohistochemistry. The chi-square test was used to compare the local/regional control rate (CR) between HPV (+)/p16 (+) patients and HPV (-)/p16 (-) patients after radical radiotherapy and evaluate the association between HPV infection and p16 expression; the Kaplan-Meier method was used to calculate overall survival (OS), and the log-rank test was used for survival difference analysis. Results: The follow-up rate was 100%.The HPV infection rate was 19%, and the positive rate of p16 was 43%. In patients who received radical radiotherapy, the local CR for HPV (+) patients was 100%, versus 54% for HPV (-) patients (P =0.026); the local CR for p16 (+) patients was 92%, versus 44% for p16 (-) patients (P=0.006); the locoregional CR for p16(-) patients was 69%, versus 22% for p16 (-) patients (P=0.009). For high-risk patients, HPV infection was significantly associated with p16 expression (P=0.000). The 3-year OS rates for p16 (+) and p16 (-) patients were 91% and 2 6 %, respectively (P=0.001). Conclusions: The p16 expression is closely associated with HPV infection in OSCC patients, and it is expected to become one of the prognostic markers in OSCC patients treated with radiotherapy. (authors)

Post-treatment PET/CT and p16 status for predicting treatment outcomes in locally advanced head and neck cancer after definitive radiation

Energy Technology Data Exchange (ETDEWEB)

Awan, Musaddiq J.; Machtay, Mitchell; Yao, Min [Case Western Reserve University and University Hospitals, Department of Radiation Oncology, Cleveland, OH (United States); Lavertu, Pierre; Zender, Chad; Rezaee, Rod; Fowler, Nicole [University Hospitals, Department of Otolaryngology and Head and Neck Surgery, Cleveland, OH (United States); Karapetyan, Lilit; Gibson, Michael [University Hospitals, Department of Medical Oncology, Cleveland, OH (United States); Wasman, Jay [University Hospitals, Department of Pathology, Cleveland, OH (United States); Faulhaber, Peter [University Hospitals, Department of Nuclear Medicine and Radiology, Cleveland, OH (United States)

2017-06-15

To retrospectively review post-treatment (post-tx) FDG-PET/CT scans in patients with advanced head and neck squamous cell carcinoma (HNSCC) and known p16 status, treated with definitive (chemo)radiation (RT). A total of 108 eligible patients had N2A or greater HNSCC treated with chemoRT from August 1, 2008, to February 28, 2015, with post-tx PET/CT within 6 months after RT. Kaplan-Meier curves, log-rank statistics, and Cox proportional hazards regression were used for statistical analysis. Median follow-up was 2.38 years. Sixty-eight (63.0%) patients had p16+ and 40 (37.0%) had p16- status. Two-year overall survival and recurrence-free survival were 93.4% and 77.8%, respectively. The negative predictive value (NPV) of PET/CT for local recurrence (LR) was 100%. The NPV for regional recurrence (RR) was 96.5% for all patients, 100% for p16+ patients, and 88.5% for p16- patients. The positive predictive value (PPV) of PET/CT for recurrence was 77.3% for all patients, 50.0% for p16+, and 78.6% for p16-. The PPV for LR was 72.7% for all patients, 50.0% for p16+ patients, and 72.7% for p16- patients. The PPV for RR was 50.0% for all patients, 33% for p16+, and 66.6% for p16-. Post-tx PET/CT and p16 status were independent predictors of recurrence-free survival (p < 0.01). Post-tx PET/CT predicts treatment outcomes in both p16 + and p16- patients, and does so independently of p16 status. P16- patients with negative PET have a 10% risk of nodal recurrence, and closer follow-up in these patients is warranted. (orig.)

The 16th P and GJ 500 report

International Nuclear Information System (INIS)

Share, J.

1996-01-01

Pipeline and Gas Journal is pleased to present its 16th annual 500 Report--a comprehensive listing of the nation's energy pipelines. The list comprises the leading 300 natural gas distribution utilities; top 100 gas transmission pipelines and top 100 liquids pipelines. The wealth of statistics includes pipeline mileage; total throughput of gas and barrels of crude oil and refined products; operating revenue; employees; and in the case of the gas distributors their number of customers. Just as important as the numbers are the trends they reveal of an energy industry continuing to undergo dramatic change. The gas industry in particular has faced a massive reorganization caused in large part by Federal Energy Regulatory Commission Order 636

Band structure and optical properties of highly anisotropic LiBa2[B10O16(OH)3] decaborate crystal

International Nuclear Information System (INIS)

Smok, P.; Kityk, I.V.; Berdowski, J.

2003-01-01

The band structure (BS), charge density distribution and linear-optical properties of the anisotropic crystal LiBa 2 [B 10 O 16 (OH) 3 ] (LBBOH) are calculated using a self-consistent norm-conserving pseudopotential method within the framework of the local-density approximation theory. A high anisotropy of the band energy gap (4.22 eV for the E parallel b, 4.46 eV for the E parallel c) and giant birefringence (up to 0.20) are found. Comparison of the theoretically calculated and the experimentally measured polarised spectra of the imaginary part of the dielectric susceptibility ε 2 shows a good agreement. The anisotropy of the charge density distribution, BS dispersion and of the optical spectra originate from anisotropy between the 2p z B-2p z O and 2p y,x B-2p y,y O bonding orbitals. The observed anisotropy in the LBBOH is principally different from that of β-BaB 2 O 4 (BBO) single crystals. In the LBBOH single crystals the anisotropy of optical and charge density distribution is caused by different projection of the orbitals originating from particular borate clusters on the particular crystallographic axes, contrary to the BBO, where the anisotropy is caused prevailingly by a different local site symmetry of oxygen within the borate planes. The observed anisotropy is analysed in terms of the band energy dispersion and space charge density distribution

Kalendar nedeli : 10 - 16 maja / Natalja Lesnaja

Index Scriptorium Estoniae

Lesnaja, Natalja

1995-01-01

Iz soderzh.: 10 maja 235 let so dnja rozhdenia Kloda Zhozefa Ruzhe de Lilja, (1760 - 1836); 13 maja 155 let so dnja rozhdenia Alfonsa Dode, (1840 - 1897); 15 maja 105 let so dnja rozhdenia Ketrin Enn Porter, (1890 - 1980); 16 maja 85 let so dnja rozhdenia Olgi Fjodorovnõ Berggolts, (1910 - 1975)

Energy Law'88 Proceedings

International Nuclear Information System (INIS)

1988-01-01

This Seminar, divided into 10 topics, covered the legal, economic and trading aspects of oil, coal, natural gas and minerals, nuclear energy was examined from the viewpoint of present government policies, the future of this source of energy and of other sources. The papers presented at the Seminar are reproduced in the Proceedings. (NEA) [fr

Small-angle p-p elastic scattering at energies between 285 and 572 Me V

CERN Document Server

Aebischer, D; Greeniaus, L G; Hess, R; Junod, A; Lechanoine-Leluc, C; Nikles, J C; Rapin, D; Serre, Claude; Werren, D W

1976-01-01

Low energy proton-proton elastic scattering has been studied using an arrangement of multiwire proportional chambers at the CERN synchrocyclotron. Accurate measurements of the angular distribution for laboratory scattering angles in the range 1.5 to 10 degrees have been made at eight incident kinetic energies between 285 and 572 MeV. The interferences between the Coulomb and nuclear scattering amplitudes is used to determine the ratio alpha /sub p/=Re phi /sup N //sub +/(o)/Im phi /sup N//sub +/(o), where phi /sup N//sub +/(o) is the non-flip nuclear forward amplitude. alpha p is found to be positive and falling with energy, but is sensitive to the type of parameterization used. Reasonable consistency with dispersion relation calculations is obtained. (21 refs).

Wormholes in viable f(R) modified theories of gravity and weak energy condition

Energy Technology Data Exchange (ETDEWEB)

Pavlovic, Petar [Universitaet Hamburg, II. Institut fuer Theoretische Physik, Hamburg (Germany); Sossich, Marko [University of Zagreb, Department of Physics, Faculty of Electrical Engineering and Computing, Zagreb (Croatia)

2015-03-01

In this work wormholes in viable f(R) gravity models are analyzed. We are interested in exact solutions for stress-energy tensor components depending on different shape and redshift functions. Several solutions of gravitational equations for different f(R) models are examined. The solutions found imply no need for exotic material, while this need is implied in the standard general theory of relativity. A simple expression for weak energy condition (WEC) violation near the throat is derived and analyzed. High curvature regime is also discussed, as well as the question of the highest possible values of the Ricci scalar for which the WEC is not violated near the throat, and corresponding functions are calculated for several models. The approach here differs from the one that has been common since no additional assumptions to simplify the equations have been made, and the functions in f(R) models are not considered to be arbitrary functions, but rather a feature of the theory that has to be evaluated on the basis of consistency with observations for the Solar System and cosmological evolution. Therefore in this work we show that the existence of wormholes without exotic matter is not only possible in simple arbitrary f(R) models, but also in models that are in accordance with empirical data. (orig.)

Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours

DEFF Research Database (Denmark)

Grønhøj Larsen, C; Gyldenløve, M; Jensen, D H

2014-01-01

A significant proportion of squamous cell carcinomas of the oropharynx (OP-SCC) are related to human papillomavirus (HPV) infection and p16 overexpression. This subgroup proves better prognosis and survival but no evidence exists on the correlation between HPV and p16 overexpression based on diag...

Prognostic impact of HPV-associated p16-expression and smoking status on outcomes following radiotherapy for oropharyngeal cancer: The MARCH-HPV project

DEFF Research Database (Denmark)

Lassen, Pernille; Lacas, Benjamin; Pignon, Jean-Pierre

2018-01-01

-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH). MATERIALS AND METHODS: Patients with OPC, known tumor p16-status and smoking history were identified from the MARCH update, resulting in a dataset of 815 patients from four randomized trials (RTOG9003, DAHANCA6&7, RTOG0129, ARTSCAN). Analysis was performed......; in the p16-positive subgroup, never smokers had significantly better PFS than former/current smokers (HR = 0.49 [0.33-0.75], 24.2% survival benefit at 10 years). CONCLUSIONS: No predictive impact of p16-status on response to AFRT could be detected but the strong prognostic impact of p16-status...

Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma

OpenAIRE

Saito, Yuki; Ando, Mizuo; Omura, Go; Yasuhara, Kazuo; Yoshida, Masafumi; Takahashi, Wataru; Yamasoba, Tatsuya

2016-01-01

Objectives/Hypothesis We aimed to determine the effectiveness of induction chemotherapy for treating p16?positive oropharyngeal cancer in our department. Study Design This was a retrospective case series to assess treatment effectiveness. Methods We administered induction chemotherapy to patients with stage III to IV oropharyngeal p16?positive squamous cell carcinoma between 2008 and 2013. Induction chemotherapy was administered using combinations of docetaxel, cisplatin, and 5?fluorouracil. ...

Implementation and research priorities for FCTC Articles 13 and 16: tobacco advertising, promotion, and sponsorship and sales to and by minors.

Science.gov (United States)

Nagler, Rebekah H; Viswanath, Kasisomayajula

2013-04-01

Article 13 of the Framework Convention on Tobacco Control (FCTC) calls for a comprehensive ban on tobacco advertising, promotion, and sponsorship (TAPS), and Article 16 calls for prohibition of tobacco sales to and by minors. Although these mandates are based on sound science, many countries have found provision implementation to be rife with challenges. This paper reviews the history of tobacco marketing and minor access restrictions in high-, middle-, and low-income countries, identifying past challenges and successes. We consider current challenges to FCTC implementation, how these barriers can be addressed, and what research is necessary to support such efforts. Specifically, we identify implementation and research priorities for FCTC Articles 13 and 16. Although a solid evidence base underpins the FCTC's call for TAPS bans and minor access restrictions, we know substantially less about how best to implement these restrictions. Drawing on the regulatory experiences of high-, middle-, and low-income countries, we discern several implementation and research priorities, which are organized into 4 categories: policy enactment and enforcement, human capital expertise, the effects of FCTC marketing and youth access policies, and knowledge exchange and transfer among signatories. Future research should provide detailed case studies on implementation successes and failures, as well as insights into how knowledge of successful restrictions can be translated into tobacco control policy and practice and shared among different stakeholders. Tobacco marketing surveillance, sales-to-minors compliance checks, enforcement and evaluation of restriction policies, and capacity building and knowledge transfer are likely to prove central to effective implementation.

Implementation and Research Priorities for FCTC Articles 13 and 16: Tobacco Advertising, Promotion, and Sponsorship and Sales to and by Minors

Science.gov (United States)

2013-01-01

Introduction: Article 13 of the Framework Convention on Tobacco Control (FCTC) calls for a comprehensive ban on tobacco advertising, promotion, and sponsorship (TAPS), and Article 16 calls for prohibition of tobacco sales to and by minors. Although these mandates are based on sound science, many countries have found provision implementation to be rife with challenges. Objective: This paper reviews the history of tobacco marketing and minor access restrictions in high-, middle-, and low-income countries, identifying past challenges and successes. We consider current challenges to FCTC implementation, how these barriers can be addressed, and what research is necessary to support such efforts. Specifically, we identify implementation and research priorities for FCTC Articles 13 and 16. Discussion: Although a solid evidence base underpins the FCTC’s call for TAPS bans and minor access restrictions, we know substantially less about how best to implement these restrictions. Drawing on the regulatory experiences of high-, middle-, and low-income countries, we discern several implementation and research priorities, which are organized into 4 categories: policy enactment and enforcement, human capital expertise, the effects of FCTC marketing and youth access policies, and knowledge exchange and transfer among signatories. Future research should provide detailed case studies on implementation successes and failures, as well as insights into how knowledge of successful restrictions can be translated into tobacco control policy and practice and shared among different stakeholders. Conclusion: Tobacco marketing surveillance, sales-to-minors compliance checks, enforcement and evaluation of restriction policies, and capacity building and knowledge transfer are likely to prove central to effective implementation. PMID:23291641

25 CFR 502.16 - Net revenues.

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Net revenues. 502.16 Section 502.16 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS OF THIS CHAPTER § 502... consistent with professional accounting pronouncements, excluding management fees. [74 FR 36932, July 27...

Simulation of energy deposit distribution in water for 10 and 25 MeV electron beams

International Nuclear Information System (INIS)

Borrell Carbonell, Maria de los Angeles.

1977-01-01

The Monte Carlo method was applied to transport simulation of electron beams from the exit window of a linear accelerator till the absorption by a water phantom. The distribution of energy deposit is calculated for ideal apparatus and experimental conditions. Calculations are made for a distance window-water surface of one meter, for 10 and 25 MeV monoenergetic incident electrons, and for different fields (15x15 cm 2 to 4x4 cm 2 ). Comparisons with experimental measurements obtained in comparable conditions with a Sagittaire accelerator (C.G.R.-MeV), show a good agreement concerning radial distribution and depth distribution around isodose 100%. However a certain disagreement appears in the end of depth penetration [fr

A LABOCA SURVEY OF THE EXTENDED CHANDRA DEEP FIELD SOUTH-SUBMILLIMETER PROPERTIES OF NEAR-INFRARED SELECTED GALAXIES

International Nuclear Information System (INIS)

Greve, T. R.; Walter, F.; Bell, E. F.; Dannerbauer, H.; Rix, H.-W.; Schinnerer, E.; Weiss, A.; Kovacs, A.; Smail, I.; Coppin, K. E. K.; Alexander, D.; Zheng, X. Z.; Knudsen, K. K.; Bertoldi, F.; De Breuck, C.; Dickinson, M.; Gawiser, E.; Lutz, D.; Brandt, N.; Chapman, S. C.

2010-01-01

Using the 330 hr ESO-MPG 870 μm survey of the Extended Chandra Deep Field South (ECDF-S) obtained with the Large Apex BOlometer CAmera (LABOCA) on the Atacama Pathfinder EXperiment (APEX), we have carried out a stacking analysis at submillimeter (submm) wavelengths of a sample of 8266 near-infra-red (near-IR) selected (K vega ≤ 20) galaxies, including 893 BzK galaxies, 1253 extremely red objects (EROs), and 737 distant red galaxies (DRGs), selected from the Multi-wavelength Survey by Yale-Chile (MUSYC). We measure average 870 μm fluxes of 0.22 ± 0.01 mJy (22.0σ), 0.48 ± 0.04 mJy (12.0σ), 0.39 ± 0.03 mJy (13.0σ), and 0.43 ± 0.04 mJy (10.8σ) for the K vega ≤ 20, BzK, ERO, and DRG samples, respectively. For the BzK, ERO, and DRG sub-samples, which overlap to some degree and are likely to be at z ≅ 1-2, this implies an average far-IR luminosity of ∼(1-5) x 10 11 L sun and star formation rate (SFR) of ∼20-90 M sun . Splitting the BzK galaxies into star-forming (sBzK) and passive (pBzK) galaxies, the former is significantly detected (0.50 ± 0.04 mJy, 12.5σ) while the latter is only marginally detected (0.34 ± 0.10 mJy, 3.4σ), thus confirming that the sBzK and pBzK criteria to some extent select obscured, star-forming, and truly passive galaxies, respectively. The K vega ≤ 20 galaxies are found to contribute 7.27 ± 0.34 Jy deg -2 (16.5% ± 5.7%) to the 870 μm extragalactic background light (EBL). sBzK and pBzK galaxies contribute 1.49 ± 0.22 Jy deg -2 (3.4% ± 1.3%) and 0.20 ± 0.14 Jy deg -2 (0.5% ± 0.3%) to the EBL. We present the first delineation of the average submm signal from the K vega ≤ 20 selected galaxies and their contribution to the submm EBL as a function of (photometric) redshift, and find a decline in the average submm signal (and therefore IR luminosity and SFR) by a factor ∼2-3 from z ∼ 2 to z ∼ 0. This is in line with a cosmic star formation history in which the star formation activity in galaxies increases

Real-time-service-based Distributed Scheduling Scheme for IEEE 802.16j Networks

OpenAIRE

Kuo-Feng Huang; Shih-Jung Wu

2013-01-01

Supporting Quality of Service (QoS) guarantees for diverse multimedia services is the primary concern for IEEE802.16j networks. A scheduling scheme that satisfies the QoS requirements has become more important for wireless communications. We proposed an adaptive nontransparent-based distributed scheduling scheme (ANDS) for IEEE 802.16j networks. ANDS comprises three major components: Priority Assignment, Resource Allocation, Preserved Bandwidth Adjustment. Different service-type connections p...

Effect of amino acid sequence and pH on nanofiber formation of self-assembling peptides EAK16-II and EAK16-IV.

Science.gov (United States)

Hong, Yooseong; Legge, Raymond L; Zhang, S; Chen, P

2003-01-01

Atomic force microscopy (AFM) and axisymmetric drop shape analysis-profile (ASDA-P) were used to investigate the mechanism of self-assembly of peptides. The peptides chosen consisted of 16 alternating hydrophobic and hydrophilic amino acids, where the hydrophilic residues possess alternating negative and positive charges. Two types of peptides, AEAEAKAKAEAEAKAK (EAK16-II) and AEAEAEAEAKAKAKAK (EAK16-IV), were investigated in terms of nanostructure formation through self-assembly. The experimental results, which focused on the effects of the amino acid sequence and pH, show that the nanostructures formed by the peptides are dependent on the amino acid sequence and the pH of the solution. For pH conditions around neutrality, one of the peptides used in this study, EAK16-IV, forms globular assemblies and has lower surface tension at air-water interfaces than another peptide, EAK16-II, which forms fibrillar assemblies at the same pH. When the pH is lowered below 6.5 or raised above 7.5, there is a transition from globular to fibrillar structures for EAK16-IV, but EAK16-II does not show any structural transition. Surface tension measurements using ADSA-P showed different surface activities of peptides at air-water interfaces. EAK16-II does not show a significant difference in surface tension for the pH range between 4 and 9. However, EAK16-IV shows a noticeable decrease in surface tension at pH around neutrality, indicating that the formation of globular assemblies is related to the molecular hydrophobicity.

76 FR 34071 - Secretary of Energy Advisory Board, Natural Gas Subcommittee; Meeting

Science.gov (United States)

2011-06-10

... INFORMATION CONTACT: Renee Stone, Deputy Designated Federal Officer, U.S. Department of Energy, 1000... address the committee are invited to send a written statement to Renee Stone, U.S. Department of Energy.... LaTanya R. Butler, Acting Deputy Committee Management Officer. [FR Doc. 2011-14439 Filed 6-9-11; 8:45 am...

The Remedial Action Priority System (RAPS): Mathematical formulations

International Nuclear Information System (INIS)

Whelan, G.; Strenge, D.L.; Droppo, J.G. Jr.; Steelman, B.L.; Buck, J.W.

1987-08-01

The Remedial Action Priority System (RAPS) represents a methodology that prioritizes inactive hazardous and radioactive mixed-waste disposal sites in a scientific and objective manner based on limited site information. This methodology is intended to bridge the technology gap between the initial site evaluation using the Hazard Ranking System (HRS) and the time-consuming process of actual field site characterization, assessment, and remediation efforts. The RAPS methodology provides the US Department of Energy with a management tool for assistance in prioritizing funding and human resource allocations for further investigations and possible remediations at its inactive waste sites. Use of RAPS will help DOE ensure that those sites posing the highest potential risk are addressed first. Chapters 1 through 10 were processed separately for the Energy Data Base

Exploitation of geothermal energy as a priority of sustainable energetic development in Serbia

International Nuclear Information System (INIS)

Golusin, Mirjana; Bagaric, Ivan; Ivanovic, Olja Munitlak; Vranjes, Sanja

2010-01-01

The actual global economic crisis, including all other well-known problems of sustainable development, reflects the direction of development of all countries in the world. Serbia, as a European country in its early stage of development, is trying to synchronize its progress with experience of other countries from the field of sustainable development and in accordance with rules in the field of energetic and energetic efficiency, and, as well as to promote and develop the sector of use of renewable sources of energy. On the other hand, Serbia is a country which largely depends on import of all forms of energy, which to a great extent affects its economic stability. Therefore, in Serbia the strategy for development of energetic was imposed and it considers all the aspects of development of energetic until 2015 and it also defines the priorities which can be mostly seen in the choice of forms of alternative sources of energy. These sources, based on some criteria, can be considered the most convenient for a gradual substitution of energy which is gotten from the conventional sources. Taking into account strategically defined goals and domestic potentials which are at disposal, as well as economic parameters, an alternative source of energy of basic importance for the future exploitation on the territory of Serbia geothermal energy, was chosen. The research points to the fact that Serbia will be capable to respond adequately to Kyoto protocol demands and to the European rules regarding the substitution of a certain amounts of fossil fuels by the fuel origin from the raw biological materials. The research defines the existent and non-existent capacities and the assessment of positive effects of usage of geothermal energy. At the moment, 160 long holes are being exploited whose water temperature is around 60 C (140 F) and their heat power reach 160 MJ/s. It was stated that adequate exploitation of existing and new geothermal sources a yearly would save about 500,000 tons

75 FR 79049 - Final Regulatory Guide: Issuance, Availability

Science.gov (United States)

2010-12-17

... opened in transit. This guide also incorporates suggestions for ensuring that TIDs are properly applied..., Division of Engineering, Office of Nuclear Regulatory Research. [FR Doc. 2010-31729 Filed 12-16-10; 8:45 am...

The overexpression of p16 is not a surrogate marker for high-risk human papilloma virus genotypes and predicts clinical outcomes for vulvar cancer

International Nuclear Information System (INIS)

Sznurkowski, Jacek J.; Żawrocki, Anton; Biernat, Wojciech

2016-01-01

We aimed to evaluate the correlation between p16 ink4a -overexpression and high risk (hr)HPV-DNA in vulvar squamous cell carcinoma (vSCC) tumors as well as the impact of both biomarkers on the prognosis of vSCC patients. PCR-detection of (hr)HPV-DNA and immunohistochemical staining for p16 ink4a were conducted in 85 vSCC tumors. Survival analyses included the Kaplan–Meier method, log-rank test and Cox proportional hazards model. p16 ink4a -overexpression and (hr)HPV-DNA were detected in 35 and 37 of the 85 tumors, respectively. Among the 35 p16 ink4a -positive tumors, 10 lacked (hr)HPV-DNA (29 %). Among the 50 p16 ink4a -negative tumors, (hr)HPV-DNA was detected in 12 cases (24 %). The median follow-up was 89.20 months (range 1.7–189.5 months). P16 ink4a -overexpression, but not (hr)HPV-DNA positivity of the primary tumor, was correlated with prolonged overall survival (OS) (p = 0.009). P16 ink4a -overexpression predicted a better response to radiotherapy (p < 0.001). Univariate analysis has demonstrated that age (p = 0.025), tumor grade (p = 0.001), lymph node metastasis (p < 0.001), FIGO stage (p < 0.001), p16 ink4a -overexpression (p = 0.022), and adjuvant RTX (p < 0.001) were prognostic factors for OS. Multivariate analysis has demonstrated that lymph node metastasis (HR 1–2.74, 95 % CI 1.50–5.02, p = 0.019), tumor grade (HR 1–2.80, 95 % CI 1.33–5.90, p = 0.007) and p16 ink4a -overexpression (HR 1–2.11, 95 % CI 1.13–3.95, p = 0.001) are independent prognostic factors. The discovered overlap suggests the use of p16 ink4a in combination with HPV-DNA detection as an ancillary test for future research and clinical studies in vSCC. The prognostic and predictive value of p16 ink4a -overexpression should be tested in larger cohort studies. The online version of this article (doi:10.1186/s12885-016-2503-y) contains supplementary material, which is available to authorized users

76 FR 17808 - Final Vehicle Safety Rulemaking and Research Priority Plan 2011-2013

Science.gov (United States)

2011-03-31

... [Docket No. NHTSA-2009-0108] Final Vehicle Safety Rulemaking and Research Priority Plan 2011- 2013 AGENCY... availability. SUMMARY: This document announces the availability of the Final NHTSA Vehicle Safety and Fuel.... This Priority Plan is an update to the Final Vehicle Safety Rulemaking and Research Priority Plan 2009...

76 FR 19980 - Funding Priorities, Requirements, and Definitions

Science.gov (United States)

2011-04-11

... use the priorities, requirements, and definitions to awards grants to State educational agencies (SEAs... Education, and Bureau of Justice Statistics, Office of Justice Programs, U.S. Department of Justice... educational agencies (LEAs), and schools to create safe, healthy, and supportive learning environments...

LOH at 16p13 is a novel chromosomal alteration detected in benign and malignant microdissected papillary neoplasms of the breast.

Science.gov (United States)

Lininger, R A; Park, W S; Man, Y G; Pham, T; MacGrogan, G; Zhuang, Z; Tavassoli, F A

1998-10-01

Papillary carcinoma of the breast is a variant of predominantly intraductal carcinoma characterized by a papillary growth pattern with fibrovascular support. Loss of heterozygosity (LOH) was evaluated at multiple chromosomal loci (including loci reported to show frequent genetic alterations in breast cancer) to determine the frequency of genetic mutations in these tumors and their precursors. Thirty-three papillary lesions of the breast (6 papillary carcinomas, 12 carcinomas arising in a papilloma, and 15 intraductal papillomas with florid epithelial hyperplasia) were retrieved from the files of the Armed Forces Institute of Pathology (AFIP). Tumor cells and normal tissue were microdissected in each case and screened for LOH at INT-2 and p53 as well as several loci on chromosome 16p13 in the TSC2/PKD1 gene region (D16S423, D16S663, D16S665). LOH on chromosome 16p13 was present in 10 of 16 (63%) informative cases of either papillary carcinoma or carcinoma arising in a papilloma as well as in 6 of 10 (60%) informative cases of intraductal papilloma with florid epithelial hyperplasia (IDH). One case showed simultaneous LOH in both the florid IDH and carcinoma components of a papilloma. LOH was not observed at either INT-2 or p53 in any of the papillary carcinomas or papillomas with florid IDH. In conclusion, a high frequency of LOH at chromosome 16p13 (the TSC2/PKD1 gene region) is in both papillary carcinomas of the breast as well as in papillomas with florid IDH, including a case with LOH present simultaneously in both components. These findings suggest that chromosome 16p contains a tumor suppressor gene that frequently is mutated early in papillary neoplasia.

Adherence of B16-F10 melanoma cells to elastin

International Nuclear Information System (INIS)

Zetter, B.R.; Netland, P.A.

1986-01-01

B16-F10 melanoma cells selectivity colonize lung tissue in vivo. The authors have previously shown that these cells adhere preferentially to lung tissue in vitro. To quantify the binding of B16-F10 cells to isolated components of lung tissue, the authors devised a dot-blot cell adhesion assay. Samples were absorbed to 4 mm dots of nylon based paper under non-denaturing conditions, blocked with albumin or hemoglobin, and incubated with radiolabelled cells for 30 min. at 4 0 C. 125 -I labelled B16-F10 cells demonstrated a dose dependent binding to mouse lung elastin. Autoradiography and scanning electron microscopy demonstrated that cells localized preferentially to the elastin dots. The melanoma cells bound more strongly to elastin relative to laminin, fibronectin, collagen types I and IV or heparan sulfate. Neither elastin-associated microfibrillar protein nor fragments of elastin produced by alkali or acid treatment demonstrated significant binding activity for these cells. The findings demonstrate that in addition to its unique mechanical properties that confer elasticity to tissues, elastin can also function as a cell adhesion molecule. The localization of elastin in the lung and its adhesive properties reported here suggest that elastin may facilitate the arrest and eventual colonization of circulating B16-F10 melanoma cells in the mouse lung

Mitigation assessment results and priorities in China

Energy Technology Data Exchange (ETDEWEB)

Wu Zongxin; Wei Zhihong [Tsinghua Univ., Beijing (China)

1996-12-31

In this paper energy related CO2 emission projections of China by 2030 are given. CO2 mitigation potential and technology options in main fields of energy conservation and energy substitution are analyzed. CO2 reduction costs of main mitigation technologies are estimated and the AHP approach is used for helping assessment of priority technologies.

Analyzing powers for the three-nucleon breakup reaction 1H(d vector,p)pn at 16 MeV

International Nuclear Information System (INIS)

Brown, R.E.; Ohlsen, G.G.; Correll, F.D.; Hardekopf, R.A.; Jarmie, N.

1980-01-01

Analyzing powers for the 1 H(d,p)pn reaction were measured at 16.0 MeV and beam polarization of approximately 0.82. Similar data for the elastic scattering 1 H(d,p) 2 H were also taken. The breakup analyzing power A/sub xz/, which attains the largest magnitude, is shown as a function of excitation energy. Angular distributions of elastic and breakup analyzing powers are compared; large differences are noted for A/sub xx/ and A/sub xz/. It is found that 1-MeV energy bins are too large to use in the study of singlet-state effects. 2 figures

Nuclear astrophysics deep underground the case of the 15N(p,γ)16O reaction at LUNA

CERN Document Server

Mazzocchi, Chiara

2010-01-01

Measuring nuclear reactions of astrophysical interest at the relevant energies is not always possible on the Earth’s surface because of the cosmic-ray background that dominates the spectra. The LUNA collaboration exploits the lowbackground enviroment of Gran Sasso National Laboratory to study these reactions at or close to the Gamow peak. The latest experimental efforts included the measurement of the 15N(p,γ)16O at beam energies between 77 and 350 keV. The status of these measurements is summarised in this contribution.

Decadal Anthropogenic Carbon Storage Along P16 and P02

Science.gov (United States)

Carter, B. R.; Feely, R. A.; Talley, L. D.; Cross, J. N.; Macdonald, A. M.; Mecking, S.; Siedlecki, S. A.

2016-02-01

The Pacific Ocean has the largest ocean basin anthropogenic carbon (Canth) inventory due to the large size of the basin. We estimate anthropogenic carbon (Canth) concentrations and decadal storages along the meridional P16 and zonal P02 lines since the mid 90s using a modified version of the extended multiple linear regression (EMLR) technique with data from the WOCE, CLIVAR, and GO-SHIP occupations of these lines. We present our estimates and map the aragonite saturation state (ΩA) decreases and saturation horizon shoaling resulting from continued Canth storage. The average storage rate was larger along both sections during the most recent decade (2000's to 2010's) than during the previous decade (1990's to 2000's), especially along P02. Significant decadal concentration increases were found in the mixed layers, shallow thermoclines, mode waters, and portions of the intermediate water masses.

Shared research priorities for pessary use in women with prolapse: results from a James Lind Alliance Priority Setting Partnership.

Science.gov (United States)

Lough, Kate; Hagen, Suzanne; McClurg, Doreen; Pollock, Alex

2018-04-28

To identify the shared priorities for future research of women affected by and clinicians involved with pessary use for the management of prolapse. A priority setting project using a consensus method. A James Lind Alliance Pessary use for prolapse Priority Setting Partnership (JLA Pessary PSP) conducted from May 2016 to September 2017 in the UK. The PSP was run by a Steering Group of three women with experience of pessary use, three experienced clinicians involved with management of prolapse, two researchers with relevant experience, a JLA adviser and a PSP leader. Two surveys were conducted in 2016 and 2017. The first gathered questions about pessaries, and the second asked respondents to prioritise a list of questions. A final workshop was held on 8 September 2017 involving 10 women and 13 clinician representatives with prolapse and pessary experience. A top 10 list of priorities for future research in pessary use for prolapse was agreed by consensus. Women with experience of pessary use and clinicians involved with prolapse management have worked together to determine shared priorities for future research. Aligning the top 10 results with existing research findings will highlight the gaps in current evidence and signpost future research to areas of priority. Effective dissemination of the results will enable research funding bodies to focus on gathering the evidence to answer the questions that matter most to those who will be affected. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Transportation energy data book: edition 16

Energy Technology Data Exchange (ETDEWEB)

Davis, S.C. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); McFarlin, D.N. [Tennessee Univ., Knoxville, TN (United States)

1996-07-01

The Transportation Energy Data Book: Edition 16 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes is treated in separate chapters or sections. Chapter 1 compares U.S. transportation data with data from other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet vehicles, federal standards, fuel economies, and high- occupancy vehicle lane data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternative fuel vehicles. Chapter 6 covers the major nonhighway modes: air, water, and rail. The last chapter, Chapter 7, presents data on environmental issues relating to transportation.

NOAA TIFF Image - 10m Bathymetry Mosaic, South Atlantic Bight - Deep Coral Priority Areas - NOAA Ron Brown - (2010), UTM 17N NAD83

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 10x10 meter cell size representing the bathymetry (depth) of several deep coral priority areas off the South Atlantic...

76 FR 29083 - Agriculture Priorities and Allocations System

Science.gov (United States)

2011-05-19

... Vol. 76 Thursday, No. 97 May 19, 2011 Part III Department of Agriculture Farm Service Agency 7 CFR Part 789 Agriculture Priorities and Allocations System; Proposed Rule #0;#0;Federal Register / Vol. 76 , No. 97 / Thursday, May 19, 2011 / Proposed Rules#0;#0; [[Page 29084

78 FR 26635 - Environmental Management Site-Specific Advisory Board, Paducah

Science.gov (United States)

2013-05-07

...On April 29, 2013, the Department of Energy (DOE) published a notice of open meeting announcing a meeting on May 16, 2013 of the Environmental Management Site-Specific Advisory Board, Paducah (78 FR 25064). This document makes a correction to that notice.

Socio-economic disparities in the consumption of vegetables, fruit and energy-dense foods: the role of motive priorities.

Science.gov (United States)

Konttinen, Hanna; Sarlio-Lähteenkorva, Sirpa; Silventoinen, Karri; Männistö, Satu; Haukkala, Ari

2013-05-01

A low socio-economic status (SES) is related to less healthy dietary habits, but the reasons for this remain unclear. We examined whether the absolute or relative importance of various food choice motives contributed to SES disparities in vegetable/fruit and energy-dense food intake. We analysed cross-sectional data from the FINRISK Study 2007 by means of structural equation modelling and used a shortened version of the Food Choice Questionnaire to assess the absolute importance of health, pleasure, convenience, price, familiarity and ethicality motives. We calculated the relative importance of each motive by dividing the participant's rating of it by his/her mean score on all motives. Dietary intake was measured with an FFQ. A population-based survey in Finland. Men (n 1691) and women (n 2059) aged 25-64 years. Higher education and income were related to a greater vegetable/fruit intake (β = 0·12, P foods (β = -0·09, P food choices in both absolute and relative terms. A higher income was related to a greater relative importance of health considerations. Relative motives were more strongly associated with vegetable/fruit and energy-dense food consumption than absolute motives and the relative importance of price, familiarity and health partly mediated the effects of the SES indicators on the consumption of these food items. Individual priorities in food choice motives, rather than the absolute importance of single motives, play a role in producing SES disparities in diet.

Limitations on anti p-p luminosity with direct injection and stacking of antiprotons

International Nuclear Information System (INIS)

Courant, E.D.; Teng, L.C.

1979-01-01

If protons of very high energy impinge on a target, a large part of the resulting antiprotons are sufficiently collimated to be injectible into a stacking and accelerating ring. They can then be stacked and injected into the main proton accelerator so as to produce anti p-p collisions without low energy antiproton cooling. A scheme is presented for the VBA, where 20 TeV protons produce 9 x 10 -4 antiprotons per proton at 100 GeV, which are then stacked, accelerated to 1 TeV, and injected into the main ring. With 16 proton pulses of 10 15 protons, one obtains a luminosity of the order of 10 32 cm -2 sec -1 with a beam-beam tune shift of 10 -3 per interaction region. The beams are bunched into 1000 bunches; the orbits are separated by means of relatively modest electostatic electrodes

A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients

International Nuclear Information System (INIS)

Chai, Ryan C.; Lim, Yenkai; Frazer, Ian H.; Wan, Yunxia; Perry, Christopher; Jones, Lee; Lambie, Duncan; Punyadeera, Chamindie

2016-01-01

Human papilloma virus-16 (HPV-16) infection is a major risk factor for a subset of head and neck squamous cell carcinoma (HNSCC), in particular oropharyngeal squamous cell carcinoma (OPSCC). Current techniques for assessing the HPV-16 status in HNSCC include the detection of HPV-16 DNA and p16 INK4a expression in tumor tissues. When tumors originate from hidden anatomical sites, this method can be challenging. A non-invasive and cost-effective alternative to biopsy is therefore desirable for HPV-16 detection especially within a community setting to screen at-risk individuals. The present study compared detection of HPV-16 DNA and RNA in salivary oral rinses with tumor p16 INK4a status, in 82 HNSCC patients using end-point and quantitative polymerase chain reaction (PCR). Of 42 patients with p16 INK4a -positive tumours, 39 (sensitivity = 92.9 %, PPV = 100 % and NPV = 93 %) had oral rinse samples with detectable HPV-16 DNA, using end-point and quantitative PCR. No HPV-16 DNA was detected in oral rinse samples from 40 patients with p16 INK4a negative tumours, yielding a test specificity of 100 %. For patients with p16 INK4a positive tumours, HPV-16 mRNA was detected using end-point reverse transcription PCR (RT-PCR) in 24/40 (sensitivity = 60 %, PPV = 100 % and NPV = 71 %), and using quantitative RT-PCR in 22/40 (sensitivity = 55 %, PPV = 100 % and NPV = 69 %). No HPV-16 mRNA was detected in oral rinse samples from the p16 INK4a -negative patients, yielding a specificity of 100 %. We demonstrate that the detection of HPV-16 DNA in salivary oral rinse is indicative of HPV status in HNSCC patients and can potentially be used as a diagnostic tool in addition to the current methods. The online version of this article (doi:10.1186/s12885-016-2217-1) contains supplementary material, which is available to authorized users

Measurements of the spin rotation parameter R in high energy elastic scattering and helicity amplitudes at Serpukhov energies

International Nuclear Information System (INIS)

Pierrard, J.; Bruneton, C.; Bystricky, J.; Cozzika, G.; Deregel, J.; Ducros, Y.; Gaidot, A.; Khantine-Langlois, F.; Lehar, F.; Lesquen, A. de; Merlo, J.P.; Miyashita, S.; Movchet, J.; Raoul, J.C.; Van Rossum, L.; Kanavets, V.P.

1975-01-01

The spin rotation parameter R in pp and π + p elastic scattering at 45GeV/c has been measured at the Serpukhov accelerator, for /t/ ranging from 0.2 to 0.5(GeV/c) 2 . The results are presented, together with previous R measurements at 3.8, 6, 16 and 40GeV/c, and are compared with the predictions of Regge pole models. The equality of the values for R in proton-proton and pion-proton scattering, within the experimental errors, is a test of factorization of the residues. An s-channel helicity amplitude analysis for pion-nucleon scattering at 40GeV/c is made using all available data. Significant results are obtained for the non flip amplitude in isoscalar exchange and for flip amplitudes on both isovector and isoscalar exchanges. The helicity flip in isoscalar exchange is non negligible. The energy dependence of this amplitude, at 6, 16 and 40GeV/c, is compared with predictions of Regge pole models [fr

Photodissociation of pyrene cations: structure and energetics from C16H10(+) to C14(+) and almost everything in between.

Science.gov (United States)

West, Brandi; Useli-Bacchitta, Francesca; Sabbah, Hassan; Blanchet, Valérie; Bodi, Andras; Mayer, Paul M; Joblin, Christine

2014-09-11

The unimolecular dissociation of the pyrene radical cation, C16H10(+•), has been explored using a combination of computational techniques and experimental approaches, such as multiple photon absorption in the cold ion trap Piège à Ions pour la Recherche et l'Etude de Nouvelles Espèces Astrochimiques (PIRENEA) and imaging photoelectron photoion coincidence spectrometry (iPEPICO). In total, 22 reactions, involving the fragmentation cascade (H, C2H2, and C4H2 loss) from the pyrene radical cation down to the C14(+•) fragment ion, have been studied using PIRENEA. Branching ratios have been measured for reactions from C16H10(+•), C16H8(+•), and C16H5(+). Density functional theory calculations of the fragmentation pathways observed experimentally and postulated theoretically lead to 17 unique structures. One important prediction is the opening of the pyrene ring system starting from the C16H4(+•) radical. In the iPEPICO experiments, only two reactions could be studied, namely, R1 C16H10(+•) → C16H9(+) + H (m/z = 201) and R2 C16H9(+) → C16H8(+•) + H (m/z = 200). The activation energies for these reactions were determined to be 5.4 ± 1.2 and 3.3 ± 1.1 eV, respectively.

Molecular and clinical description of a girl with a 46,X,t(Y;4)(q11.2;p16)/45,X,der(4)t(Y;4)(q11.2;p16) karyotype and a small cryptic 4p subtelomeric deletion.

Science.gov (United States)

Zahed, Laila; Sismani, Carolina; Ioannides, M; Saleh, Monzer; Koumbaris, G; Kenj, Mazen; Abdallah, Amal; Ayyache, Maya; Patsalis, Philippos

2008-04-01

We report on a 13-year-old female with short stature, minimal axillary and pubic hair, no breast development, absence of uterus and ovaries, with the following karyotype on lymphocyte cultures: 46,X,t(Y;4)(q11.2;p16)[40]/45,X,der(4)t(Y;4)(q11.2;p16)[10]. Loss of the small derivative Y chromosome in 20% of the cells was also confirmed in skin fibroblast cultures. FISH analyses using Y centromere, SRY, subtelomere XpYp/XqYq, Y and 4 painting probes, confirmed the cytogenetic findings. High-resolution STS analyses using 40 markers covering the Y chromosome did not identify any deletion on the Y. However, de novo absence of the 4p subtelomeric region was noted by FISH, although this deletion was not revealed by Array-CGH at 1 Mb resolution, the last array clone being 0.35 or 1 Mb distal to the 4p FISH probe. The female phenotype of this patient must be due to the loss of the derivative Y chromosomes in some of her cells, especially the gonads, while the 4p subtelomeric deletion does not seem to contribute to her phenotype. Copyright 2008 Wiley-Liss, Inc.

The p16INK4alpha/p19ARF gene mutations are infrequent and are mutually exclusive to p53 mutations in Indian oral squamous cell carcinomas.

Science.gov (United States)

Kannan, K; Munirajan, A K; Krishnamurthy, J; Bhuvarahamurthy, V; Mohanprasad, B K; Panishankar, K H; Tsuchida, N; Shanmugam, G

2000-03-01

Eighty-seven untreated primary oral squamous cell carcinomas (SCCs) associated with betel quid and tobacco chewing from Indian patients were analysed for the presence of mutations in the commonly shared exon 2 of p16INK4alpha/p19ARF genes. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and sequencing analysis were used to detect mutations. SSCP analysis indicated that only 9% (8/87) of the tumours had mutation in p16INK4alpha/p19ARF genes. Seventy-two tumours studied here were previously analysed for p53 mutations and 21% (15/72) of them were found to have mutations in p53 gene. Only one tumour was found to have mutation at both p53 and p16INK4alpha/p19ARF genes. Thus, the mutation rates observed were 21% for p53, 9% for p16INK4alpha/p19ARF, and 1% for both. Sequencing analysis revealed two types of mutations; i) G to C (GCAG to CCAG) transversion type mutation at intron 1-exon 2 splice junction and ii) another C to T transition type mutation resulting in CGA to TGA changing arginine to a termination codon at p16INK4alpha gene codon 80 and the same mutation will alter codon 94 of p19ARF gene from CCG to CTG (proline to leucine). These results suggest that p16INK4alpha/p19ARF mutations are less frequent than p53 mutations in Indian oral SCCs. The p53 and p16INK4alpha/p19ARF mutational events are independent and are mutually exclusive suggesting that mutational inactivation of either p53 or p16INK4alpha/p19ARF may alleviate the need for the inactivation of the other gene.

Transverse energy distribution, charged particle multiplicities and spectra in 16O-nucleus collisions

International Nuclear Information System (INIS)

Sunier, J.W.

1987-01-01

The HELIOS (High Energy Lepton and Ion Spectrometer) experiment, installed at the CERN Super Proton Synchrotron, proposes to examine in details the physical properties of a state of high energy created in nuclei by ultra-relativistic nucleus-nucleus collisions. It is generally believed that, at high densities or temperatures, a phase transition to a plasma of quark and gluons will occur. The dynamic of the expansion of such a plasma and its subsequent condensation into a hadron gas should markedly affect the composition and momentum distribution of the emerging particles and photons. The HELIOS experimental setup therefore combines 4π calorimetric coverage with measurements of inclusive particle spectra, two particle correlations, low and high mass lepton pairs and photons. The emphasis is placed on transverse energy flow (E/sub T/) measurements with good energy resolution, and the ability to trigger the acquisition of data in a variety of E/sub T/ ranges, thereby selecting the impact parameter or the violence of the collisions. This short note presents HELIOS results, for the most part still preliminary, on 16 O-nucleus collisions at the incident energies of 60 and 200 GeV per nucleon. The E/sub T/ distributions from Al, Ag and W targets are discussed and compared to the associated charged particle multiplicities from W. Charged particle and (converted) photon spectra measured with the external magnetic spectrometer are compared for 16 O + W and p + W collisions at 200 GeV per nucleon. 5 refs., 7 figs

Accurate accelerator energy calibration using selected resonances in proton elastic scattering and in (p,γ) and (p,p‧γ) reactions

Science.gov (United States)

Paneta, V.; Kokkoris, M.; Lagoyannis, A.; Preketes-Sigalas, K.

2017-09-01

The present work aims at contributing to the field of Ion Beam Analysis by providing a set of standard, high-accuracy nuclear resonance reaction data points to be used for accelerator energy calibration up to 4.6 MeV, more specifically with the use of the 27Al(p,γ), 13C(p,γ), 12C(p,p0) and 32S(p,p‧γ) resonant reactions, as a result of a comprehensive investigation in two different laboratories. The use of resonances at higher energies, namely up to 6 MeV, is also discussed. The measurements have been performed at two different electrostatic accelerators, namely at the 5.5 MV HV TN-11 of NCSR "Demokritos", Greece, and at the 5 MV 15SDH-2 Pelletron Tandem accelerator at Uppsala University in Uppsala, Sweden. Common points were used to normalize and validate the data. The possible use of the 16O(p,p0) resonance at 3.47 MeV is also discussed and analyzed.

Immunohistochemical characteristic of expression levels of Kі-67, p16INK4a, HPV16 in cervical intraepithelial neoplasia and cervical cancer

Directory of Open Access Journals (Sweden)

V. A. Tumanskiy

2017-08-01

Full Text Available Squamous cervical cancer (SCC is a common tumor in women, which is preceded by the series of pathological processes, among which the key role is played by cervical intraepithelial neoplasia (CIN. Aim. To study the characteristics of immunohistochemical (IHC expression of Ki-67, p16INK4a, HPV16 in squamous cervical epithelium (SCE with dysplastic changes of varying degree (CIN I–III and also in the tumor cells of SCC. Materials and methods. Pathohistological and IHC studies of uterine cervix biopsies from 53 patients (the age ranged from 18 to 45 years were performed. Results. It was found that SCE with CIN I is characterized by the low Ki-67 expression level (Me = 17.87 % (13.76, 22.44 and the extremely low p16INK4a expression level (Me = 0.00 CUOD (0.00; 29.64. The proportion of HPV16-positive patients with CIN I is 27.27 %. CIN II is characterized by the average proliferation level in SCE (Me = 44.96 % (34.91, 55.41 and the moderate p16INK4a expression level (Me = 75.71 CUOD (51.24, 82, 41. The proportion of HPV16-positive patients with CIN II is 71.43 %. CIN III is characterized by the high proliferation level (Me = 74.62 % (68.50, 84.67 and by the high p16INK4a expression level of in SCE (Me = 117.47 CUOD (95.38, 123, 93; the proportion of HPV16-positive patients with CIN III is 77.78%. In all the patients with SСС, nuclear and cytoplasmic expression of HPV16 was detected in the tumor cells. High expression levels of Ki-67 and p16INK4a were detected in the tumor cells. There are direct correlations between the expression levels of Ki-67, p16INK4a, HPV16 and CIN degree. Conclusions. These data indicate that the expression levels of Ki-67, p16INK4a and HPV16 increase with the increasing of CIN grade. The absence of statistically significant differences between the expression levels of Ki-67, p16INK4a and HPV16 in CIN III and the same levels in the tumor cells of SCC indicates that these markers cannot be used for differential diagnosis

10 CFR 221.11 - Natural gas and ethane.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Natural gas and ethane. 221.11 Section 221.11 Energy DEPARTMENT OF ENERGY OIL PRIORITY SUPPLY OF CRUDE OIL AND PETROLEUM PRODUCTS TO THE DEPARTMENT OF DEFENSE UNDER THE DEFENSE PRODUCTION ACT Exclusions § 221.11 Natural gas and ethane. The supply of natural gas...

Kinetics of bainite precipitation in the Cu{sub 69.3}Al{sub 18.8}Mn{sub 10.3}Ag{sub 1.6} alloy

Energy Technology Data Exchange (ETDEWEB)

Motta, M.B.J.L. [Departamento de Ciências Exatas e da Terra, UNIFESP, Diadema, SP (Brazil); Adorno, A.T.; Santos, C.M.A. [Departamento de Físico-Química, IQ-UNESP, Araraquara, SP (Brazil); Silva, R.A.G., E-mail: galdino.ricardo@gmail.com [Departamento de Ciências Exatas e da Terra, UNIFESP, Diadema, SP (Brazil)

2017-02-15

In this work the kinetics of bainite precipitation in the Cu{sub 69.3}Al{sub 18.8}Mn{sub 10.3}Ag{sub 1.6} alloy was studied using measurements of microhardness change with aging time, scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analyses, measurements of magnetization change with applied field and high-resolution transmission electron microscopy (HRTEM). The results showed that the bainite precipitation is responsible for the hardness increase in the Cu{sub 69.3}Al{sub 18.8}Mn{sub 10.3}Ag{sub 1.6} alloy. The activation energy value obtained for the bainite precipitation is lower than that found in the literature. This was attributed to the presence of Ag dissolved in matrix and the occurrence of the Cu{sub 3}Al(DO{sub 3}) → Cu{sub 2}AlMn(L2{sub 1}) ordering reaction together with the bainite precipitation. - Highlights: • The activation energy for the bainite precipitation in the Cu{sub 69.3}Al{sub 18.8}Mn{sub 10.3}Ag{sub 1.6} alloy is around 33 kJ/mol. • During bainite precipitation the Cu{sub 2}AlMn phase formation occurs. • The Cu{sub 3}Al(DO{sub 3}) → Cu{sub 2}AlMn(L2{sub 1}) ordering reaction interferes in the activation energy value.

Atomic Energy Control Act, c A.19, s.1

International Nuclear Information System (INIS)

1985-01-01

The Revised Statutes of Canada 1985 entered into force on 12 December 1988, revoking the previous Atomic Energy Control Act and replacing it with a new version. The new Act (Chapter A-16 of the Revised Statutes) updates the previous text and makes some linguistic corrections. The Atomic Energy Control Act establishes the Atomic Energy Control Board and sets out its duties and powers which include, in particular, the making of regulations for developing, controlling and licensing the production, application and use of atomic energy [fr

Inhibition of ERK1/2 or AKT Activity Equally Enhances Radiation Sensitization in B16F10 Cells

Science.gov (United States)

Kalal, Bhuvanesh Sukhlal; Fathima, Faraz; Pai, Vinitha Ramanath; Sanjeev, Ganesh; Krishna, Chilakapati Murali; Upadhya, Dinesh

2018-01-01

Background The aim of the study was to evaluate the radiation sensitizing ability of ERK1/2, PI3K-AKT and JNK inhibitors in highly radiation resistant and metastatic B16F10 cells which carry wild-type Ras and Braf. Methods Mouse melanoma cell line B16F10 was exposed to 1.0, 2.0 and 3.0 Gy of electron beam radiation. Phosphorylated ERK1/2, AKT and JNK levels were estimated by ELISA. Cells were exposed to 2.0 and 3.0 Gy of radiation with or without prior pharmacological inhibition of ERK1/2, AKT as well as JNK pathways. Cell death induced by radiation as well as upon inhibition of these pathways was measured by TUNEL assay using flow cytometry. Results Exposure of B16F10 cells to 1.0, 2.0 and 3.0 Gy of electron beam irradiation triggered an increase in all the three phosphorylated proteins compared to sham-treated and control groups. B16F10 cells pre-treated with either ERK1/2 or AKT inhibitors equally enhanced radiation-induced cell death at 2.0 as well as 3.0 Gy (P < 0.001), while inhibition of JNK pathway increased radiation-induced cell death to a lesser extent. Interestingly combined inhibition of ERK1/2 or AKT pathways did not show additional cell death compared to individual ERK1/2 or AKT inhibition. This indicates that ERK1/2 or AKT mediates radiation resistance through common downstream molecules in B16F10 cells. Conclusions Even without activating mutations in Ras or Braf genes, ERK1/2 and AKT play a critical role in B16F10 cell survival upon radiation exposure and possibly act through common downstream effector/s. PMID:29581812

Expression of Anion Exchanger 1 Sequestrates p16 in the Cytoplasm in Gastric, Colonic Adenocarcinoma

Directory of Open Access Journals (Sweden)

Wei-Wei Shen

2007-10-01

Full Text Available p16INK4A (p16 binds to cyclin-dependent kinase 4/6, negatively regulates cell growth. Recent studies have led to an understanding of additional biologic functions for p16; however, the detailed mechanisms involved are still elusive. In this article, we show an unexpected expression of anion exchanger 1 (AEi in the cytoplasm in poorly, moderately differentiated gastric, colonic adenocarcinoma cells, in its interaction with p16, thereby sequestrating the protein in the cytoplasm. Genetic alterations of p16, AEi were not detectable. Forced expression of AEi in these cells sequestrated more p16 in the cytoplasm, whereas small interfering RNA-mediated silencing of AEi in the cells induced the release of p16 from the cytoplasm to the nucleus, leading to cell death, growth inhibition of tumor cells. By analyzing tissue samples obtained from patients with gastric, colonic cancers, we found that 83.33% of gastric cancers, 56.52% of colonic cancers coexpressed AEi, p16 in the cytoplasm. We conclude that AEi plays a crucial role in the pathogenesis of gastric, colonic adenocarcinoma, that p16 dysfunction is a novel pathway of carcinogenesis.

16 CFR 309.10 - Alternative vehicle fuel rating.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Alternative vehicle fuel rating. 309.10... LABELING REQUIREMENTS FOR ALTERNATIVE FUELS AND ALTERNATIVE FUELED VEHICLES Requirements for Alternative Fuels Duties of Importers, Producers, and Refiners of Non-Liquid Alternative Vehicle Fuels (other Than...

A systematic review of stated preference studies reporting public preferences for healthcare priority setting.

Science.gov (United States)

Whitty, Jennifer A; Lancsar, Emily; Rixon, Kylie; Golenko, Xanthe; Ratcliffe, Julie

2014-01-01

There is current interest in incorporating weights based on public preferences for health and healthcare into priority-setting decisions. The aim of this systematic review was to explore the extent to which public preferences and trade-offs for priority-setting criteria have been quantified, and to describe the study contexts and preference elicitation methods employed. A systematic review was performed in April 2013 to identify empirical studies eliciting the stated preferences of the public for the provision of healthcare in a priority-setting context. Studies are described in terms of (i) the stated preference approaches used, (ii) the priority-setting levels and contexts, and (iii) the criteria identified as important and their relative importance. Thirty-nine studies applying 40 elicitation methods reported in 41 papers met the inclusion criteria. The discrete choice experiment method was most commonly applied (n = 18, 45.0 %), but other approaches, including contingent valuation and the person trade-off, were also used. Studies prioritised health systems (n = 4, 10.2 %), policies/programmes/services/interventions (n = 16, 41.0 %), or patient groups (n = 19, 48.7 %). Studies generally confirmed the importance of a wide range of process, non-health and patient-related characteristics in priority setting in selected contexts, alongside health outcomes. However, inconsistencies were observed for the relative importance of some prioritisation criteria, suggesting context and/or elicitation approach matter. Overall, findings suggest caution in directly incorporating public preferences as weights for priority setting unless the methods used to elicit the weights can be shown to be appropriate and robust in the priority-setting context.

76 FR 58716 - Telemarketing Sales Rule

Science.gov (United States)

2011-09-22

... FEDERAL TRADE COMMISSION 16 CFR Part 310 Telemarketing Sales Rule AGENCY: Federal Trade Commission... Telemarketing Sales Rule in the Federal Register on August 10, 2010 (75 FR 48458), with new provisions to..., Division of Marketing Practices, Bureau of Consumer Protection, Federal Trade Commission, Washington, DC...

16 CFR 0.10 - Office of the Executive Director.

Science.gov (United States)

2010-01-01

... on strategic planning and assessing the management and resource implications of any proposed action..., financial management, information technology, and human resources. [65 FR 78408, Dec. 15, 2000] ... Chairman, is the chief operating official who develops and implements management and administrative...

p16 gene methylation in colorectal cancer patients with long-term follow-up Metilación de p16 en pacientes intervenidos de cáncer colorrectal tras un largo periodo de seguimiento

Directory of Open Access Journals (Sweden)

Silvia Veganzones-de-Castro

2012-03-01

Full Text Available Introduction: p16 gene plays an important role in the cell cycle regulation and is considered an important tumor suppressor gene. Several mechanisms of gene inactivation have been described; in this study we have focused on p16 gene promoter methylation. In colorectal cancer p16 gene methylation is a frequent event. Methods: 326 patients with sporadic colorectal cancer were included. DNA was extracted from tumor tissue samples obtained during the surgical procedure. Promoter methylation was analyzed using bisulfite modification and was detected by quantitative methylation-specific PCR. Frequency of p16 methylation was analyzed and compared with other clinicopathological variables. Results: p16 gene methylation was detected in 24,8% of patients. Methylation was associated with differentiation grade and with tumor location: methylation was frequent in poorly differentiated tumors and had low frequency in distal colon. The p16 promoter methylation discriminated a subgroup of patients with better prognosis in poorly differentiated tumors. Conclusions: p16 methylation was a frequent event in our population and was able to induce differences in the overall survival of patients with poorly differentiated tumors.Introducción: el gen p16 está implicado en la regulación del ciclo celular y se considera un importante gen supresor de tumores. Objetivos: se han descrito diferentes mecanismos de inactivación génica, en este estudio nos hemos centrado en la metilación del promotor del gen p16. En el cáncer colorrectal la metilación de p16 es una alteración frecuente. Material y métodos: se incluyeron 326 pacientes con cáncer colorrectal esporádico. El ADN se extrajo de muestras tumorales obtenidas durante la cirugía. La metilación del promotor se analizó mediante un proceso de modificación con bisulfito y posterior PCR cuantitativa especifica para metilación. Se analizó la frecuencia de la metilación de p16 y se comparó con las variables

Combined Radix-10 and Radix-16 Division Unit

DEFF Research Database (Denmark)

Lang, Tomas; Nannarelli, Alberto

2007-01-01

In this work we extend a previously proposed digit-recurrence radix-10 division unit to be able to perform also radix-16 division. The extension is simplified by the fact that in the radix-10 implementation the quotient digit is decomposed into two parts and that this decomposition is also...... the selection constants. The rest of the modifications relate to the generation of multiples, to the carry-save adder, to the carry-propagate adder, and to the on-the-fly conversion and rounding. The implementation results show that the delay of an iteration is similar to that of the radix-10 case...

Redesigning pH optimum of Geobacillus sp. TF16 endoxylanase through in silico designed DNA swapping strategy.

Science.gov (United States)

Uzuner, Ugur; Canakci, Sabriye; Bektas, Kadriye Inan; Sapmaz, Merve Tuncel; Belduz, Ali Osman

2017-06-01

Thermoalkaliphilic xylanases are highly desired and of great importance due to their vast potential in paper pulp and bleaching processes. Here, we report rapid, cost-effective, and result-oriented combinatorial potential of in silico DNA swapping strategy to engineer the pH optimum of industrially crucial enzymes, particularly engineering of Geobacillus sp. TF16 endoxylanase for alkaline environments. The 3D structures of Geobacillus sp. TF16 and donor Bacillus halodurans C-125 endoxylanases were firstly predicted, analyzed, and compared for their similarities before any in silico design of mutants. Reasonably, to improve its alkaline pH tolerance, the corresponding regions in Geobacillus sp.TF16 endoxylanase were further engineered by swapping with negatively-charged amino acid-rich regions from B. halodurans C-125 endoxylanase. Through only two of four in silico-designed mutants, the optimum pH of GeoTF16 endoxylanase was improved from 8.5 to 10.0. Moreover, as compared to GeoTF16 parental enzyme, both GeoInt3 and GeoInt4 mutants revealed (i) enhanced biobleaching performance, (ii) improved adaptability to alkaline conditions, and (iii) better activity for broader pH range. Unlike GeoTF16 losing activity at pH 11.0 completely, GeoInt4 retained 60% and 40% of its activity at pH 11.0 and 12.0, respectively. Thus, GeoInt4 stands out as a more competent biocatalyst that is suitable for alkaline environments of diverse industrial applications. The current study represents an efficient protein engineering strategy to adapt industrial catalysts to diverse processing conditions. Further comprehensive and fine-tuned research efforts may result in biotechnologically more promising outcomes. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Priority image transmission in wireless sensor networks

International Nuclear Information System (INIS)

Nasri, M.; Helali, A.; Sghaier, H.; Maaref, H.

2011-01-01

The emerging technology during the last years allowed the development of new sensors equipped with wireless communication which can be organized into a cooperative autonomous network. Some application areas for wireless sensor networks (WSNs) are home automations, health care services, military domain, and environment monitoring. The required constraints are limited capacity of processing, limited storage capability, and especially these nodes are limited in energy. In addition, such networks are tiny battery powered which their lifetime is very limited. During image processing and transmission to the destination, the lifetime of sensor network is decreased quickly due to battery and processing power constraints. Therefore, digital image transmissions are a significant challenge for image sensor based Wireless Sensor Networks (WSNs). Based on a wavelet image compression, we propose a novel, robust and energy-efficient scheme, called Priority Image Transmission (PIT) in WSN by providing various priority levels during image transmissions. Different priorities in the compressed image are considered. The information for the significant wavelet coeffcients are transmitted with higher quality assurance, whereas relatively less important coefficients are transmitted with lower overhead. Simulation results show that the proposed scheme prolongs the system lifetime and achieves higher energy efficiency in WSN with an acceptable compromise on the image quality.

CERN Shop: Christmas Sale, 10 & 16.12.2004

CERN Multimedia

2004-01-01

Looking for Christmas present ideas? Come to the Reception Shop Special Stand in Meyrin, Main Building, ground floor, on Friday 10 and/or on Thursday 16 December from 10:30 to 16:00. CERN 50th Anniversary sweat-shirt (grey in M, L, XL) 30.- CERN 50th Anniversary T-shirt, (S, M, L, XL) 20.- CERN 50th Anniversary silk tie (2 colours) 30.- Einstein silk tie (blue, grey) 45.- Silk scarf 40.- Swiss army knife with CERN logo 25.- Swiss Duo-Pack with CERN logo 30.- CERN 50th Anniversary watch (2 models) 40.- CERN pens (2 models) 5.- Small Open Day souvenirs (a few different items) 2.- CERN 50th Anniversary Book (English & French) 70.- "Prestigious Discoveries" at CERN (English/anglais) 32.- "Particle Odyssey" soft cover (English/anglais) 35.- If you miss this special occasion, the articles are also available at the Reception Shop in Building 33 from Monday to Saturday between 08:30 and 17:00 hrs. Education and Communica...

78 FR 5330 - Proposed Priorities and Definitions-NIDRR DRRP-Community Living and Participation, Health and...

Science.gov (United States)

2013-01-25

... outcomes for transition-aged youth with disabilities. (vii) Vocational rehabilitation (VR) practices that... priorities, we designate the type of each priority as absolute, competitive preference, or invitational...)). Competitive preference priority: Under a competitive preference priority, we give competitive preference to an...

Elastic scattering of 16O+16O at energies E/A between 5 and 8 MeV

International Nuclear Information System (INIS)

Nicoli, M. P.; Haas, F.; Freeman, R. M.; Aissaoui, N.; Beck, C.; Elanique, A.; Nouicer, R.; Morsad, A.; Szilner, S.; Basrak, Z.

1999-01-01

The elastic scattering of 16 O+ 16 O has been measured at nine energies between E lab =75 and 124 MeV. The data cover up to 100 degree sign in the c.m. and can be described in terms of phenomenological and folding model potentials which reproduce the main features observed. In agreement with studies at higher energies in this and similar systems, refractive effects are present in the angular distributions at all energies. In particular, the passage of Airy minima through 90 degree sign at E c.m. =40, 47.5, and 62 MeV explains the deep minima observed in the excitation function. The real part of the optical potential is found to vary very little with energy over the studied interval, but the imaginary part shows a rapid change in its shape at incident energy about 90 MeV. Nonetheless, the energy dependence of the volume integral of the real and imaginary parts is in agreement with dispersion relation predictions. (c) 1999 The American Physical Society

Spectroscopic study of nuclei of the 1f-2p layer by means of (16O,14C) and (16O,12C) transfer reactions

International Nuclear Information System (INIS)

Mallet-Lemaire, M.C.

1973-01-01

One-and two-nucleon transfer reactions induced by light projectiles have long been established as powerful spectroscopic tools to test one-and two-nucleon configurations of the wave functions describing the excited states of the residual nucleus A comparatively to the target nuclei A-1 and A-2. As soon as heavy ion beams became available, a further step was made in the experimental study of few-nucleon configurations by increasing the number of transferred particles as well as the variety of reactions leading to the same residual nucleus. It is well known that many theoretical models emphasize the role played by four-nucleon correlations in the microscopic description of deformed states. An experimental study of the reaction mechanism for ( 16 0, 12 C) and ( 16 0, 14 C) has been carried out by measuring angular distributions at several incident energies and excitation functions. A semi-classical description of the experimental results shows the strong influence of nuclear distortions on multi-nucleon-transfer reactions which appear with increasing incident energies. It will be noticed that spectroscopic information concerning the transferred nucleons can be achieved only through a complete finite range DWBA calculation including a microscopic nuclear structure form factor. The relative influence of the kinematic factors and nuclear structure factors on the DWBA cross-sections has been also investigated. The preliminary results on the DWBA analysis of the 54 Fe( 16 0, 12 C) 58 Ni and 48 Ca( 16 O, 14 C) 50 Ti angular distributions are discussed. Finally, ( 16 0, 14 C) and ( 16 0, 12 C) transfer reactions on different 1f-2p shell targets are described

76 FR 71014 - Idaho Power Company, IDACORP Energy, L.P., IDACORP, Inc.; Notice of Petition

Science.gov (United States)

2011-11-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. IN03-9-000] Idaho Power Company, IDACORP Energy, L.P., IDACORP, Inc.; Notice of Petition Take notice that on September 9, 2011..., 2003,\\1\\ filed a petition to terminate Appendix B, Appendix C, and Appendix E to the Settlement...

Approximations for the waiting-time distribution in an M/P H/c priority queue

NARCIS (Netherlands)

Al Hanbali, Ahmad; Alvarez, Elisa; van der Heijden, Matthijs C.

2015-01-01

We investigate the use of priority mechanisms when assigning service engineers to customers as a tool for service differentiation. To this end, we analyze a non-preemptive M/PH/c priority queue with various customer classes. For this queue, we present various accurate and fast methods to estimate

10 CFR 835.103 - Education, training and skills.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Education, training and skills. 835.103 Section 835.103... § 835.103 Education, training and skills. Individuals responsible for developing and implementing... education, training, and skills to discharge these responsibilities. [63 FR 59682, Nov. 4, 1998] ...

Structure of 10Be and 16C nuclei via break-up reactions studied with the 4π Chimera array

Science.gov (United States)

Dell'Aquila, D.; Acosta, L.; Amorini, F.; Andolina, R.; Auditore, L.; Berceanu, I.; Cardella, G.; Chatterjiee, M. B.; De Filippo, E.; Francalanza, L.; Gnoffo, B.; Grzeszczuk, A.; Lanzalone, G.; Lombardo, I.; Martorana, N.; Minniti, T.; Pagano, A.; Pagano, E. V.; Papa, M.; Pirrone, S.; Politi, G.; Pop, A.; Porto, F.; Quattrocchi, L.; Rizzo, F.; Rosato, E.; Russotto, P.; Trifirò, A.; Trimarchi, M.; Verde, G.; Vigilante, M.

2018-01-01

The study of cluster states in neutron-rich Be and C isotopes is a subject of interest in Nuclear Physics. These states should be characterized by high deformation where α-clusters are bounded by valence neutrons. We performed a spectroscopic study of 10Be and 16C isotopes via projectile break-up reactions, by using radioactive beams produced at the INFN-LNS FRIBs facility and the Chimera 4π array. The possible evidence of a new 10Be state at 13.5 MeV excitation energy was found in the 6He+4He disintegration channel. The spectroscopy of 16C was studied via the 6He+10Be break-up channel; in this case we found the indication of a possible new state at about 20.6 MeV.

NOAA TIFF Image - 10m Backscatter Mosaic, South Atlantic Bight - Deep Coral Priority Areas - NOAA Ship Nancy Foster - (2009), UTM 17N NAD83

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 10x10 meter cell size representing the backscatter (intensity) of several deep coral priority areas off the South...

NOAA TIFF Image - 10m Backscatter Mosaic, South Atlantic Bight - Deep Coral Priority Areas - NOAA Ship Nancy Foster - (2010), UTM 17N NAD83

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 10x10 meter cell size representing the backscatter (intensity) of several deep coral priority areas off the South...

16 CFR 1015.10 - Commission report of actions to Congress.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Commission report of actions to Congress. 1015.10 Section 1015.10 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROCEDURES FOR... U.S.C. 552(a) § 1015.10 Commission report of actions to Congress. On or before February 1 of each...

Nuclear interactions of super high energy cosmic-rays observed by mountain emulsion chambers

International Nuclear Information System (INIS)

1981-01-01

Here is presented a summary of joint discussions on the results of three mountain experiments with large-scale emulsion chambers, at Pamir, Mt. Fuji and Chacaltaya. The observation covers gamma-quanta, hadrons and their clusters (called ''families''). Following topics are covered concerning on characteristics of nuclear interactions in energy region of 10 14 - 10 16 eV: 1) rapid dissipation seen in atmospheric diffusion of high energy cosmic-rays, 2) multiplicity and p sub(t) increase in produced pimesons in the fragmentation region, 3) existence of large p sub(t) jets, 4) extremely-hadron-rich family of Centauro type, 5) exotic phenomena at extremely high energy region beyond 10 16 eV. (author)

Integral measurement of the {sup 12}C(n, p){sup 12}B reaction up to 10 GeV

Energy Technology Data Exchange (ETDEWEB)

Zugec, P.; Bosnar, D. [University of Zagreb, Department of Physics, Faculty of Science, Zagreb (Croatia); Colonna, N.; Barbagallo, M.; Mastromarco, M.; Tagliente, G.; Variale, V. [Istituto Nazionale di Fisica Nucleare, Bari (Italy); Ventura, A. [Istituto Nazionale di Fisica Nucleare, Bologna (Italy); Mengoni, A. [ENEA, Bologna (Italy); Altstadt, S.; Langer, C.; Lederer, C.; Reifarth, R.; Schmidt, S.; Weigand, M. [Johann-Wolfgang-Goethe Universitaet, Frankfurt (Germany); Andrzejewski, J.; Marganiec, J.; Perkowski, J. [Uniwersytet Lodzki, Lodz (Poland); Audouin, L.; Leong, L.S.; Tassan-Got, L. [Centre National de la Recherche Scientifique/IN2P3 - IPN, Orsay (France); Becares, V.; Cano-Ott, D.; Garcia, A.R.; Gonzalez-Romero, E.; Martinez, T.; Mendoza, E. [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas (CIEMAT), Madrid (Spain); Becvar, F.; Krticka, M.; Kroll, J.; Valenta, S. [Charles University, Prague (Czech Republic); Belloni, F.; Mondalaers, W.; Plompen, A.; Schillebeeckx, P. [European Commission JRC, Institute for Reference Materials and Measurements, Geel (Belgium); Berthoumieux, E.; Fraval, K.; Gunsing, F. [CEA/Saclay - IRFU, Gif-sur-Yvette (France); Billowes, J.; Ware, T.; Wright, T. [University of Manchester, Manchester (United Kingdom); Boccone, V.; Brugger, M.; Calviani, M.; Cerutti, F.; Chiaveri, E.; Chin, M.; Ferrari, A.; Guerrero, C.; Losito, R.; Roman, F.; Rubbia, C.; Tsinganis, A.; Versaci, R.; Vlachoudis, V.; Weiss, C. [CERN, Geneva (Switzerland); Calvino, F.; Cortes, G.; Gomez-Hornillos, M.B.; Riego, A. [Universitat Politecnica de Catalunya, Barcelona (Spain); Carrapico, C.; Goncalves, I.F.; Sarmento, R.; Vaz, P. [Universidade de Lisboa, C2TN-Instituto Superior Tecnico, Lisboa (Portugal); Cortes-Giraldo, M.A.; Praena, J.; Quesada, J. [Universidad de Sevilla, Sevilla (Spain); Cosentino, L.; Finocchiaro, P. [INFN - Laboratori Nazionali del Sud, Catania (Italy); Diakaki, M.; Karadimos, D.; Kokkoris, M.; Vlastou, R. [National Technical University of Athens (NTUA), Athens (Greece); Domingo-Pardo, C.; Giubrone, G.; Tain, J.L. [CSIC-Universidad de Valencia, Instituto de Fisica Corpuscular, Valencia (Spain); Dressler, R.; Heinitz, S.; Kivel, N.; Schumann, D. [Paul Scherrer Institut, Villigen (Switzerland); Duran, I.; Tarrio, D. [Universidade de Santiago de Compostela, Santiago de Compostela (Spain); Eleftheriadis, C.; Manousos, A. [Aristotle University of Thessaloniki, Thessaloniki (Greece); Ganesan, S.; Gurusamy, P.; Saxena, A. [Bhabha Atomic Research Centre (BARC), Mumbai (India); Griesmayer, E.; Jericha, E.; Leeb, H. [Atominstitut der Oesterreichischen Universitaeten, Technische Universitaet Wien, Wien (Austria); Jenkins, D.G.; Vermeulen, M.J. [University of York, York, Heslington (United Kingdom); Kaeppeler, F. [Karlsruhe Institute of Technology (KIT), Institut fuer Kernphysik, Karlsruhe (Germany); Lo Meo, S. [Istituto Nazionale di Fisica Nucleare, Bologna (Italy); ENEA, Bologna (Italy); Massimi, C.; Mingrone, F.; Vannini, G. [Dipartimento di Fisica, Universita di Bologna (IT); INFN, Bologna (IT); Mastinu, P. [Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Legnaro (IT); Milazzo, P.M. [Istituto Nazionale di Fisica Nucleare, Trieste (IT); Mirea, M. [Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN HH, Magurele (RO); Musumarra, A. [Universita di Catania, Dipartimento di Fisica e Astronomia DFA, Catania (IT); INFN-Laboratori Nazionali del Sud, Catania (IT); Paradela, C. [European Commission JRC, Institute for Reference Materials and Measurements, Geel (BE); Universidade de Santiago de Compostela, Santiago de Compostela (ES); Pavlik, A. [Faculty of Physics, University of Vienna, Wien (AT); Rauscher, T. [University of Hertfordshire, Centre for Astrophysics Research, School of Physics, Astronomy and Mathematics, Hatfield (GB); University of Basel, Department of Physics, Basel (CH); Wallner, A. [Faculty of Physics, University of Vienna, Wien (AT); Australian National University, Research School of Physics and Engineering, Canberra (AU)

2016-04-15

The integral measurement of the {sup 12}C(n, p){sup 12}B reaction was performed at the neutron time-of-flight facility nTOF at CERN. The total number of {sup 12}B nuclei produced per neutron pulse of the nTOF beam was determined using the activation technique in combination with a time-of-flight technique. The cross section is integrated over the nTOF neutron energy spectrum from reaction threshold at 13.6 MeV to 10 GeV. Having been measured up to 1GeV on basis of the {sup 235}U(n, f) reaction, the neutron energy spectrum above 200 MeV has been re-evaluated due to the recent extension of the cross section reference for this particular reaction, which is otherwise considered a standard up to 200 MeV. The results from the dedicated GEANT4 simulations have been used to evaluate the neutron flux from 1 GeV up to 10 GeV. The experimental results related to the {sup 12}C(n, p){sup 12}B reaction are compared with the evaluated cross sections from major libraries and with the predictions of different GEANT4 models, which mostly underestimate the {sup 12}B production. On the contrary, a good reproduction of the integral cross section derived from measurements is obtained with TALYS-1.6 calculations, with optimized parameters. (orig.)

Investigations of neutron-rich nuclei at the dripline through their analogue states : The cases of $^{10}$Li - $^{10}$Be (T=2) and $^{17}$C - $^{17}$N (T=5/2)

CERN Multimedia

2002-01-01

We propose to study the elastic resonance scattering reactions $^{9}$Li+p and $^{16}$C+p to investigate the energies, spins and parities of the lowest T=2 states in $^{10}$Be and the T=5/2 states in $^{17}$N. These are analogue states of the ground states and first excited states in $^{10}$Li and $^{17}$C.

77 FR 34229 - Idaho: Final Authorization of State Hazardous Waste Management Program; Revision

Science.gov (United States)

2012-06-11

... waste regulated under RCRA. In 2003, EPA proposed the sector as an enforcement priority for fiscal years...) Amendments (73 FR 18970, April 8, 2008); F019 Exemption for Wastewater Treatment Sludges from Auto... Comparable Fuel Exclusion (75 FR 33712, June 15, 2010). The federal regulation for the Export of Shipments of...

THE 1.6 μm NEAR-INFRARED NUCLEI OF 3C RADIO GALAXIES: JETS, THERMAL EMISSION, OR SCATTERED LIGHT?

International Nuclear Information System (INIS)

Baldi, Ranieri D.; Chiaberge, Marco; Sparks, William; Macchetto, F. Duccio; Capetti, Alessandro; O'Dea, Christopher P.; Axon, David J.; Baum, Stefi A.; Quillen, Alice C.

2010-01-01

Using HST NICMOS 2 observations we have measured 1.6 μm near-infrared nuclear luminosities of 100 3CR radio galaxies with z < 0.3, by modeling and subtracting the extended emission from the host galaxy. We performed a multiwavelength statistical analysis (including optical and radio data) of the properties of the nuclei following classification of the objects into FR I and FR II, and low-ionization galaxies (LIGs), high-ionization galaxies (HIGs), and broad-line objects (BLOs) using the radio morphology and optical spectra, respectively. The correlations among near-infrared, optical, and radio nuclear luminosity support the idea that the near-infrared nuclear emission of FR Is has a non-thermal origin. Despite the difference in radio morphology, the multiwavelength properties of FR II LIG nuclei are statistically indistinguishable from those of FR Is, an indication of a common structure of the central engine. All BLOs show an unresolved near-infrared nucleus and a large near-infrared excess with respect to FR II LIGs and FR Is of equal radio core luminosity. This requires the presence of an additional (and dominant) component other than the non-thermal light. Considering the shape of their spectral energy distribution, we ascribe the origin of their near-infrared light to hot circumnuclear dust. A near-infrared excess is also found in HIGs, but their nuclei are substantially fainter than those of BLO. This result indicates that substantial obscuration along the line of sight to the nuclei is still present at 1.6 μm. Nonetheless, HIG nuclei cannot simply be explained in terms of dust obscuration: a significant contribution from light reflected in a circumnuclear scattering region is needed to account for their multiwavelength properties.

Two decades of Pacific anthropogenic carbon storage and ocean acidification along Global Ocean Ship-based Hydrographic Investigations Program sections P16 and P02

Science.gov (United States)

Carter, B. R.; Feely, R. A.; Mecking, S.; Cross, J. N.; Macdonald, A. M.; Siedlecki, S. A.; Talley, L. D.; Sabine, C. L.; Millero, F. J.; Swift, J. H.; Dickson, A. G.; Rodgers, K. B.

2017-02-01

A modified version of the extended multiple linear regression (eMLR) method is used to estimate anthropogenic carbon concentration (Canth) changes along the Pacific P02 and P16 hydrographic sections over the past two decades. P02 is a zonal section crossing the North Pacific at 30°N, and P16 is a meridional section crossing the North and South Pacific at 150°W. The eMLR modifications allow the uncertainties associated with choices of regression parameters to be both resolved and reduced. Canth is found to have increased throughout the water column from the surface to 1000 m depth along both lines in both decades. Mean column Canth inventory increased consistently during the earlier (1990s-2000s) and recent (2000s-2010s) decades along P02, at rates of 0.53 ± 0.11 and 0.46 ± 0.11 mol C m-2 a-1, respectively. By contrast, Canth storage accelerated from 0.29 ± 0.10 to 0.45 ± 0.11 mol C m-2 a-1 along P16. Shifts in water mass distributions are ruled out as a potential cause of this increase, which is instead attributed to recent increases in the ventilation of the South Pacific Subtropical Cell. Decadal changes along P16 are extrapolated across the gyre to estimate a Pacific Basin average storage between 60°S and 60°N of 6.1 ± 1.5 PgC decade-1 in the earlier decade and 8.8 ± 2.2 PgC decade-1 in the recent decade. This storage estimate is large despite the shallow Pacific Canth penetration due to the large volume of the Pacific Ocean. By 2014, Canth storage had changed Pacific surface seawater pH by -0.08 to -0.14 and aragonite saturation state by -0.57 to -0.82.

Prompt and isolated photons in 8.16 TeV p+Pb collisions with ATLAS

CERN Document Server

Hill, Kurt Keys; The ATLAS collaboration

2018-01-01

The inclusive production cross-section for isolated, prompt photons in p+Pb collisions at √sNN = 8.16 TeV is studied with the ATLAS detector at the LHC using a data set with an integrated luminosity of 162 nb−1. The cross-section is measured as a function of photon transverse energy from 25 to 500 GeV and over nearly five units of pseudorapidity, including kinematic regions in both the downstream proton– and nucleus–going directions. Results are reported in the nucleon–nucleon center of mass collision frame. The nuclear modification factor RpPb is reported using a extrapolation, derived using NLO pQCD, of a previous measurement of photon production in pp collisions at 8 TeV. The cross-sections and RpPb values are compared to the results of a next-to-leading order perturbative QCD calculation and to the expectations based on a picture of the energy loss of partons incoming to the hard scattering. At large nucleus-going rapidity, the cross-section is suppressed due to the different up and down valence...

NOAA TIFF Image - 10m Bathymetric Rugosity, South Atlantic Bight - Deep Coral Priority Areas - NOAA Ship Nancy Foster - (2007), UTM 17N NAD83